TY - JOUR T1 - Biomechanical Analysis Comparing a Traditional Superior-Inferior Arthroscopic Rotator Interval Closure With a Novel Medial-Lateral Technique in a Cadaveric Multidirectional Instability Model AN - 746272579; 12609182 AB - Background: Commonly performed arthroscopic rotator interval closure techniques that imbricate the rotator interval in a superior-inferior direction have been unable to reproduce the stabilizing effects of an open medial-lateral rotator interval imbrication.Hypothesis: The medial-lateral rotator interval closure will allow less inferior and posterior glenohumeral translation than the superior-inferior rotator interval closure, and the medial-lateral rotator interval closure will result in less loss of external rotation than the superior-inferior closure.Study Design: Controlled laboratory study.Methods: Eight match-paired cadaveric shoulders were stretched to 10% beyond the maximum range of motion in 0 and 60 of glenohumeral abduction to create a multidirectional instability model. Shoulders were then repaired using a superior-inferior rotator interval closure or an arthroscopic medial-lateral rotator interval closure with an anchor in the humeral head. Rotational range of motion, glenohumeral translation, and humeral head apex position were measured for intact, stretched, and repaired conditions in both 0 and 60 of glenohumeral abduction.Results: In 0 of abduction, after both rotator interval closure techniques, external rotation decreased significantly (by 4.4%; P < .05) relative to the stretched state and was restored to the intact state. In 60 of abduction, only the medial-lateral rotator interval closure restored range of motion to the intact state. In 60 of abduction, the medial-lateral rotator interval closure was more effective in reducing posterior translation than was the superior-inferior closure (P = .03).Conclusion: The medial-lateral rotator interval closure restored range of motion to the intact state better than the superior-inferior closure. Compared with the superior-inferior rotator interval closure, the medial-lateral closure significantly decreased posterior translation with the shoulder in abduction and external rotation.Clinical Relevance: Arthroscopic medial-lateral rotator interval closure with a suture anchor in the humeral head can be considered in the surgical treatment of patients with multidirectional instability, especially those with a component of posterior instability, without concern for excessive loss of range of motion. JF - American Journal of Sports Medicine AU - Farber, Adam J AU - ElAttrache, Neal S AU - Tibone, James E AU - McGarry, Michelle H AU - Lee, Thay Q AD - the Orthopaedic Biomechanics Laboratory, VA Healthcare System, Long Beach, California and University of California, Irvine, California, Kerlan-Jobe Orthopaedic Clinic, Los Angeles, California, The CORE Institute-Southwest Valley, Goodyear, Arizona, tqlee@med.va.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 1178 EP - 1185 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 37 IS - 6 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Measurement KW - Flexibility KW - Analysis KW - Techniques KW - Shoulders KW - Patients KW - Sports medicine KW - Biomechanics (sports techniques) KW - Biomechanics KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746272579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Biomechanical+Analysis+Comparing+a+Traditional+Superior-Inferior+Arthroscopic+Rotator+Interval+Closure+With+a+Novel+Medial-Lateral+Technique+in+a+Cadaveric+Multidirectional+Instability+Model&rft.au=Farber%2C+Adam+J%3BElAttrache%2C+Neal+S%3BTibone%2C+James+E%3BMcGarry%2C+Michelle+H%3BLee%2C+Thay+Q&rft.aulast=Farber&rft.aufirst=Adam&rft.date=2009-06-01&rft.volume=37&rft.issue=6&rft.spage=1178&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F0363546508330142 LA - English DB - Physical Education Index N1 - Date revised - 2010-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Measurement; Analysis; Flexibility; Techniques; Patients; Shoulders; Biomechanics (sports techniques); Sports medicine; Biomechanics DO - http://dx.doi.org/10.1177/0363546508330142 ER - TY - JOUR T1 - Monothermal caloric screening test performance: a relative operating characteristic curve analysis. AN - 742776055; pmid-19322091 AB - OBJECTIVE: The objective of the present study was to evaluate the performance of the monothermal caloric screening test in a large sample of patients. DESIGN: A retrospective analysis of the medical records of 1002 consecutive patients who had undergone vestibular assessment at the Mayo Clinic during the years 1989 and 1990 was conducted. Patients with incomplete alternate binaural bithermal (ABB) caloric testing, congenital or periodic alternating nystagmus, or bilateral vestibular loss were excluded from the study. Clinical decision theory analyses (relative operating characteristic curves) were used to determine the accuracy with which the monothermal warm (MWST) and monothermal cool (MCST) caloric screening tests predicted the results of the ABB caloric test. Cumulative distributions were constructed as a function of the cutoff points for monothermal interear difference (IED) to select the cutoff point associated with any combination of true-positive and false-positive rates. RESULTS: Both MWST and MCST performed well above chance level. The test performance for the MWST was significantly better than that of the MCST for three of the four ABB gold standards. A 10% IED cutoff point for the MWST yielded a false-negative rate of either 1% (UW >or=25%) or 3% (UW >or=20%). The use of a 10% IED (UW >or=25%) for the MWST would have resulted in a 40% reduction (N = 294) in the number of ABB caloric tests performed on patients without a unilateral weakness. CONCLUSIONS: The results of this study indicated that the MWST decreases test time without sacrificing the sensitivity of the ABB caloric test. JF - Ear and hearing AU - Murnane, Owen D AU - Akin, Faith W AU - Lynn, Susan G AU - Cyr, David G AD - Vestibular Research Laboratory, James H. Quillen VA Medical Center, Mountain Home, Tennessee 37684, USA. owen.murnane@med.va.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 313 EP - 319 VL - 30 IS - 3 SN - 0196-0202, 0196-0202 KW - Index Medicus KW - National Library of Medicine KW - Sensitivity and Specificity KW - Young Adult KW - Reproducibility of Results KW - Humans KW - Reference Standards KW - Retrospective Studies KW - Aged KW - Child KW - False Positive Reactions KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Adolescent KW - Nystagmus, Physiologic KW - Male KW - Female KW - Vestibule, Labyrinth -- physiology KW - Caloric Tests -- standards KW - Vestibular Diseases -- diagnosis KW - Mass Screening -- standards KW - Caloric Tests -- methods KW - Vestibular Diseases -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742776055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+hearing&rft.atitle=Monothermal+caloric+screening+test+performance%3A+a+relative+operating+characteristic+curve+analysis.&rft.au=Murnane%2C+Owen+D%3BAkin%2C+Faith+W%3BLynn%2C+Susan+G%3BCyr%2C+David+G&rft.aulast=Murnane&rft.aufirst=Owen&rft.date=2009-06-01&rft.volume=30&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Ear+and+hearing&rft.issn=01960202&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Mouse models of Huntington's disease and methodological considerations for therapeutic trials. AN - 67328743; 19362590 AB - Huntington's disease (HD) is an autosomal dominant, progressive, and fatal neurodegenerative disorder caused by an expanded polyglutamine cytosine-adenine-guanine repeat in the gene coding for the protein huntingtin. Despite great progress, a direct causative pathway from the HD gene mutation to neuronal dysfunction and death has not yet been established. One important advance in understanding the pathogenic mechanisms of this disease has been the development of multiple murine models that replicate many of the clinical, neuropathological, and molecular events in HD patients. These models have played an important role in providing accurate and experimentally accessible systems to study multiple aspects of disease pathogenesis and to test potential therapeutic treatment strategies. Understanding how disease processes interrelate has become important in identifying a pharmacotherapy in HD and in the design of clinical trials. A review of the current state of HD mouse models and their successes in elucidating disease pathogenesis are discussed. There is no clinically proven treatment for HD that can halt or ameliorate the inexorable disease progression. As such, a guide to assessing studies in mouse models and salient issues related to translation from mice to humans are included. JF - Biochimica et biophysica acta AU - Ferrante, Robert J AD - Geriatric Research Education and Clinical Center, Bedford Veterans Administration Medical Center, Bedford, Massachusetts 01730, USA. rjferr@bu.edu Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 506 EP - 520 VL - 1792 IS - 6 SN - 0006-3002, 0006-3002 KW - Biomarkers KW - 0 KW - HTT protein, human KW - Htt protein, mouse KW - Huntingtin Protein KW - Nerve Tissue Proteins KW - Neurotoxins KW - Nuclear Proteins KW - Index Medicus KW - Animals KW - Nuclear Proteins -- genetics KW - Neurotoxins -- metabolism KW - Humans KW - Biomarkers -- analysis KW - Treatment Outcome KW - Mice KW - Nerve Tissue Proteins -- genetics KW - Mice, Transgenic KW - Energy Metabolism KW - Drug Evaluation, Preclinical KW - Huntington Disease -- etiology KW - Huntington Disease -- therapy KW - Disease Models, Animal KW - Huntington Disease -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67328743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Mouse+models+of+Huntington%27s+disease+and+methodological+considerations+for+therapeutic+trials.&rft.au=Ferrante%2C+Robert+J&rft.aulast=Ferrante&rft.aufirst=Robert&rft.date=2009-06-01&rft.volume=1792&rft.issue=6&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbadis.2009.04.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-17 N1 - Date created - 2009-06-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Mol Genet. 2000 Mar 1;9(4):503-13 [10699173] Cell. 2000 Mar 31;101(1):57-66 [10778856] Trends Neurosci. 2000 Jun;23(6):239-45 [10838590] Hum Mol Genet. 2000 Aug 12;9(13):2009-18 [10942430] Trends Neurosci. 2000 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Neurosci. 2008 Jun 11;28(24):6182-95 [18550760] Neurobiol Dis. 2008 Jul;31(1):80-8 [18502655] Neuroscience. 2008 Nov 11;157(1):280-95 [18805465] Neurology. 2009 Feb 3;72(5):426-31 [19188573] Am J Hum Genet. 1999 Feb;64(2):339-45 [9973270] Nat Neurosci. 2002 Aug;5(8):731-6 [12089530] Neurobiol Dis. 2002 Aug;10(3):410-26 [12270701] J Neurosci. 2002 Oct 15;22(20):8942-50 [12388601] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbadis.2009.04.001 ER - TY - JOUR T1 - Comparison of costs and utilization among buprenorphine and methadone patients. AN - 67276959; 19466922 AB - Buprenorphine is an effective alternative to methadone for treatment of opioid dependence, but economic concerns represent a barrier to implementation. The economic impacts of buprenorphine adoption by the US Veterans Health Administration (VHA) were examined. Prescriptions of buprenorphine, methadone treatment visits, health-care utilization and cost, and diagnostic data were obtained for 2005. VHA dispensed buprenorphine to 606 patients and methadone to 8191 other patients during the study year. An analysis that controlled for age and diagnosis found that the mean cost of care for the 6 months after treatment initiation was $11,597 for buprenorphine and $14,921 for methadone (P < 0.001). Cost was not significantly different in subsequent months. The first 6 months of buprenorphine treatment included an average of 66 ambulatory care visits, significantly fewer than the 137 visits in methadone treatment (P < 0.001). In subsequent months, buprenorphine patients had 8.4 visits, significantly fewer than the 21.0 visits of methadone patients (P < 0.001). Compared to new methadone episodes, new buprenorphine episodes had 0.634 times the risk of ending [95% confidence interval 0.547-0.736]. Implementation of buprenorphine treatment was not associated with an influx of new opioid-dependent patients. Despite the higher cost of medication, buprenorphine treatment was no more expensive than methadone treatment. VHA methadone treatment costs were higher than reported by other providers. Although new buprenorphine treatment episodes lasted longer than new methadone episodes, buprenorphine is recommended for more adherent patients. JF - Addiction (Abingdon, England) AU - Barnett, Paul G AD - Veterans Affairs Health Economics Resource Center and Department of Health Research and Policy, Stanford University, CA, USA. paul.barnett@va.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 982 EP - 992 VL - 104 IS - 6 KW - Narcotic Antagonists KW - 0 KW - Buprenorphine KW - 40D3SCR4GZ KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Young Adult KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Health Care Costs KW - Methadone -- therapeutic use KW - Buprenorphine -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Methadone -- economics KW - Buprenorphine -- economics KW - Opioid-Related Disorders -- rehabilitation KW - Opioid-Related Disorders -- economics KW - Drug Utilization -- economics KW - Narcotic Antagonists -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67276959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Comparison+of+costs+and+utilization+among+buprenorphine+and+methadone+patients.&rft.au=Barnett%2C+Paul+G&rft.aulast=Barnett&rft.aufirst=Paul&rft.date=2009-06-01&rft.volume=104&rft.issue=6&rft.spage=982&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=1360-0443&rft_id=info:doi/10.1111%2Fj.1360-0443.2009.02539.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-05 N1 - Date created - 2009-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1360-0443.2009.02539.x ER - TY - JOUR T1 - Organizational contexts of primary care approaches for managing problem drinking. AN - 67188533; 19004595 AB - Little is known about the organizational contexts associated with different primary care (PC) approaches to managing PC patients with drinking problems. Relying upon the Chronic Care Model and a theoretically based taxonomy of health care systems, we identified organizational factors distinguishing PC practices using PC-based approaches (managed by PC providers, mental health specialists, or jointly with specialty services) versus referral-based management in the Veterans Affairs health care system. Data were obtained from a national survey of 218 PC practices characterizing usual management approaches as well as practices' leadership, delivery system design, information system, and decision support characteristics and from a national survey of substance use disorder specialty programs. PC- and referral-based practices did not differ on the sufficiency of their structural resources, physician staffing, or on the availability of specialty services. However, PC-based practices were found to take more responsibility for managing patients' chronic conditions and had more staff for decision support activities. JF - Journal of substance abuse treatment AU - Schutte, Kathleen AU - Yano, Elizabeth M AU - Kilbourne, Amy M AU - Wickrama, Bhagya AU - Kirchner, JoAnn E AU - Humphreys, Keith AD - Center for Health Care Evaluation, Department of Veterans Affairs, Veterans Affairs Palo Alto Health Care System, Menlo Park Division (MPD-152) 795, Menlo Park, CA 94025, USA. kathleen.schutte@va.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 435 EP - 445 VL - 36 IS - 4 KW - Index Medicus KW - United States KW - Humans KW - Referral and Consultation -- organization & administration KW - Databases, Factual KW - Quality Assurance, Health Care -- organization & administration KW - United States Department of Veterans Affairs -- organization & administration KW - Decision Support Techniques KW - Models, Organizational KW - Alcohol-Related Disorders -- rehabilitation KW - Primary Health Care -- methods KW - Primary Health Care -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67188533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Organizational+contexts+of+primary+care+approaches+for+managing+problem+drinking.&rft.au=Schutte%2C+Kathleen%3BYano%2C+Elizabeth+M%3BKilbourne%2C+Amy+M%3BWickrama%2C+Bhagya%3BKirchner%2C+JoAnn+E%3BHumphreys%2C+Keith&rft.aulast=Schutte&rft.aufirst=Kathleen&rft.date=2009-06-01&rft.volume=36&rft.issue=4&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=1873-6483&rft_id=info:doi/10.1016%2Fj.jsat.2008.09.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-10 N1 - Date created - 2009-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jsat.2008.09.002 ER - TY - JOUR T1 - Valproate treatment and cocaine cue reactivity in cocaine dependent individuals. AN - 67161337; 19375250 AB - Based on prior clinical trials indicating that gamma-aminobutyric acid (GABA)-based anticonvulsant medications reduce drug craving in cocaine dependent study participants, we tested the effects of valproate treatment on cue-induced cocaine craving. Crack cocaine dependent individuals (N=20) were tested in a randomized, placebo-controlled, within-subjects, crossover study design. Valproate treatment was titrated up to 1500 mg/day by Day 6 of treatment, cue testing was completed on Day 8 of treatment, and all study participants underwent a washout period of 5 days between active and placebo medication treatment periods. Testing included both cocaine and neutral cue exposure sessions, presented in a random and counterbalanced order. Main effects of cue exposure were found for subjective ratings of "desire to use cocaine now", the cocaine craving index, cocaine-like high, and cocaine withdrawal. Treatment interaction effects were found with "desire to use cocaine now", which underwent a greater increase following cocaine cue exposure in the valproate condition. Main effects of medication treatment were found, in which lower blood pressure and heart rate, and higher plasma cortisol levels, were associated with valproate treatment. Valproate treatment was also associated, at a trend level, with higher pre-test cocaine craving levels. The results demonstrate that cocaine cue reactivity is a robust phenomena across two assessment sessions, but fail to support the use of valproate as a means of reducing spontaneous and cue-induced cocaine craving. The use of valproate as a treatment for cocaine dependence is not supported. JF - Drug and alcohol dependence AU - Reid, Malcolm S AU - Thakkar, Vatsal AD - Department of Psychiatry, New York University School of Medicine, 550 1st Ave., New York, NY 10016, United States of America. malcolm.reid@va.gov Y1 - 2009/06/01/ PY - 2009 DA - 2009 Jun 01 SP - 144 EP - 150 VL - 102 IS - 1-3 KW - Antimanic Agents KW - 0 KW - Crack Cocaine KW - Valproic Acid KW - 614OI1Z5WI KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Affect -- drug effects KW - Double-Blind Method KW - Humans KW - Depression -- psychology KW - Adult KW - Cross-Over Studies KW - Galvanic Skin Response -- drug effects KW - Middle Aged KW - Male KW - Female KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- drug therapy KW - Cues KW - Antimanic Agents -- therapeutic use KW - Valproic Acid -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67161337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Valproate+treatment+and+cocaine+cue+reactivity+in+cocaine+dependent+individuals.&rft.au=Reid%2C+Malcolm+S%3BThakkar%2C+Vatsal&rft.aulast=Reid&rft.aufirst=Malcolm&rft.date=2009-06-01&rft.volume=102&rft.issue=1-3&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=1879-0046&rft_id=info:doi/10.1016%2Fj.drugalcdep.2009.02.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-16 N1 - Date created - 2009-04-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychopharmacology (Berl). 2000 Feb;148(3):314-21 [10755745] Psychopharmacology (Berl). 2007 May;192(1):147-58 [17345064] J Clin Psychopharmacol. 2000 Jun;20(3):305-10 [10831016] Brain Res. 2000 Aug 25;874(2):216-20 [10960607] Synapse. 2000 Nov;38(2):198-215 [11018794] Psychopharmacology (Berl). 2000 Oct;152(2):140-8 [11057517] Neuropsychopharmacology. 2000 Dec;23(6):633-44 [11063919] Subst Use Misuse. 2000 Oct-Dec;35(12-14):2011-30 [11138715] Ann N Y Acad Sci. 2001 Jun;937:1-26 [11458532] J Psychoactive Drugs. 2001 Jul-Sep;33(3):283-7 [11718321] Ann Acad Med Singapore. 2001 Nov;30(6):625-31 [11817292] Zh Nevrol Psikhiatr Im S S Korsakova. 2001;101(11):26-30 [11765608] Alcohol Alcohol. 2002 Sep-Oct;37(5):478-84 [12217943] Synapse. 2003 Dec 1;50(3):261-5 [14515344] Addiction. 2003 Nov;98(11):1625-32 [14616189] J Clin Psychiatry. 2003 Dec;64(12):1440-8 [14728105] Psychopharmacology (Berl). 2004 Feb;171(4):441-9 [14504683] Psychopharmacol Bull. 2003;37 Suppl 2:89-97 [15021864] Drug Alcohol Depend. 2004 Mar 8;73(3):279-87 [15036550] Drug Alcohol Depend. 2004 Sep 6;75(3):233-40 [15283944] Drugs Today (Barc). 2004 Jul;40(7):603-19 [15510234] Arch Int Pharmacodyn Ther. 1982 May;257(1):32-58 [6810779] Biochem Pharmacol. 1982 Jul 1;31(13):2257-61 [6812585] J Pers Soc Psychol. 1988 Jun;54(6):1063-70 [3397865] J Consult Clin Psychol. 1988 Dec;56(6):893-7 [3204199] Clin Endocrinol (Oxf). 1989 Apr;30(4):389-95 [2557180] Neuropharmacology. 1990 Mar;29(3):255-9 [2325832] Addict Behav. 1990;15(4):355-65 [2248109] Psychopharmacology (Berl). 1992;106(2):143-53 [1549642] No To Shinkei. 1992 Mar;44(3):234-40 [1591100] Psychopharmacology (Berl). 1992;107(4):523-9 [1603895] Addict Behav. 1992 Sep-Oct;17(5):491-9 [1332435] Br J Addict. 1992 Nov;87(11):1537-48 [1458033] Neurosci Lett. 1993 Oct 1;160(2):177-80 [8247350] Am J Psychiatry. 1995 May;152(5):778-83 [7726319] Drug Alcohol Depend. 1995 Oct;39(3):213-21 [8556970] Lancet. 1996 Feb 24;347(9000):504-8 [8596268] Drug Alcohol Depend. 1996 Nov;42(3):167-74 [8912799] Am J Psychiatry. 1998 Feb;155(2):200-6 [9464198] Drug Alcohol Depend. 1998 Jan 1;49(2):95-104 [9543646] Trends Pharmacol Sci. 1998 Feb;19(2):67-74 [9550944] Epilepsia. 1998 Apr;39(4):420-6 [9578032] Addict Behav. 1998 Jul-Aug;23(4):449-61 [9698974] Neuropsychopharmacology. 1999 Mar;20(3):297-307 [10063490] Drug Alcohol Depend. 1999 Feb 1;53(3):223-30 [10080048] Eur J Pharmacol. 1999 Jul 21;377(2-3):167-73 [10456426] Synapse. 1999 Nov;34(2):103-10 [10502309] Synapse. 2005 Feb;55(2):122-5 [15543630] Addiction. 2005 Mar;100 Suppl 1:43-57 [15730349] Addiction. 2005 Mar;100 Suppl 1:68-77 [15730351] Pharmacol Ther. 2005 Oct;108(1):94-108 [16083966] Curr Psychiatry Rep. 2005 Oct;7(5):329-36 [16216150] Addict Biol. 2007 Jun;12(2):133-51 [17508985] Drug Alcohol Depend. 2007 Dec 1;91(2-3):141-8 [17629631] Pharmacol Biochem Behav. 2008 Nov;91(1):155-64 [18674556] Pharmacol Biochem Behav. 2005 Nov;82(3):569-73 [16332385] J Child Neurol. 2005 Oct;20(10):848-51 [16417885] Psychopharmacology (Berl). 2006 Mar;184(3-4):628-36 [16163529] Psychopharmacology (Berl). 2006 Mar;184(3-4):645-51 [16432681] Subst Abus. 2005 Jun;26(2):5-14 [16687365] Addict Behav. 2007 Feb;32(2):410-5 [16814474] Drug Alcohol Depend. 2007 Feb 23;87(1):1-9 [16930857] Int J Neuropsychopharmacol. 2007 Feb;10(1):85-98 [16448579] Eur J Pharmacol. 2000 Apr 28;395(2):129-35 [10794818] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.drugalcdep.2009.02.010 ER - TY - JOUR T1 - The effect of extending high-frequency bandwidth on the Acceptable Noise Level (ANL) of hearing-impaired listeners AN - 57311484; 201000601 AB - This study examined the effects of extending high-frequency bandwidth, for both a speech signal and a background noise, on the acceptable signal-to-noise ratio (SNR) of listeners with mild sensorineural hearing loss through utilization of the Acceptable Noise Level (ANL) procedure. In addition to extending high-frequency bandwidth, the effects of reverberation time and background noise type and shape were also examined. The study results showed a significant increase in the mean ANL (i.e. participants requested a better SNR for an acceptable listening situation) when high-frequency bandwidth was extended from 3 to 9 kHz and from 6 to 9 kHz. No change in the ANL of study participants was observed as a result of isolated modification to reverberation time or background noise stimulus. An interaction effect, however, of reverberation time and background noise stimulus was demonstrated. These findings may have implications for future design of hearing aid memory programs for listening to speech in the presence of broadband background noise. Adapted from the source document. JF - International Journal of Audiology AU - Johnson, Earl AU - Ricketts, Todd AU - Hornsby, Benjamin AD - U.S. Department of Veterans Affairs, Mountain Home, TN, USA, East Tennessee State University, Johnson City, TN, USA Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 353 EP - 362 PB - Informa Healthcare, Taylor and Francis, London UK VL - 48 IS - 6 SN - 1499-2027, 1499-2027 KW - Listening KW - Stimulus KW - Listeners KW - Noise KW - Hearing KW - Speech KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57311484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Development+and+verification+of+a+%22virtual%22+cohort+using+the+National+VA+Health+Information+System.&rft.au=Fultz%2C+Shawn+L%3BSkanderson%2C+Melissa%3BMole%2C+Larry+A%3BGandhi%2C+Neel%3BBryant%2C+Kendall%3BCrystal%2C+Stephen%3BJustice%2C+Amy+C&rft.aulast=Fultz&rft.aufirst=Shawn&rft.date=2006-08-01&rft.volume=44&rft.issue=8+Suppl+2&rft.spage=S25&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-01-05 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Noise; Speech; Listening; Listeners; Stimulus; Hearing DO - http://dx.doi.org/10.1080/14992020802662964 ER - TY - JOUR T1 - Quality Measures for Supportive Cancer Care: The Cancer Quality-ASSIST Project AN - 57304591; 200922933 AB - Patients and physicians often cite symptom control as one of their most important goals in cancer care. Despite this, a previous systematic review found few tools for evaluating the quality of supportive cancer management. We developed a comprehensive set of quality indicators for evaluating pain and nonpain symptom management as well as care planning needs in cancer patients. Based on the prevalence and quality-of-life data, clinician-researchers prioritized pain, psychosocial distress, dyspnea, nausea and vomiting, fatigue and anorexia, treatment-associated toxicities, and information and care planning for quality-indicator development. Using search terms and selection criteria, we identified English-language documents from Medline (1997-2007) and Internet-based searches. Based on this evidence, clinician-reviewers proposed process quality indicators. We then used the VA Health Services Research and Development (VA HSR & D) appropriateness methods to compile the ratings of a multidisciplinary, international expert panel of the validity and feasibility of each indicator. The panel judged 92 out of 133 (69%) proposed quality indicators valid and feasible (15 out of 23 pain, 5 out of 6 depression, 8 out of 11 dyspnea, 15 out of 19 nausea and vomiting, 13 out of 26 fatigue and anorexia, 23 out of 32 other treatment-associated toxicities, and 13 out of 16 information and care planning). Of the final indicators, 67 are potentially useful for inpatient and 81 for outpatient evaluation, and 26 address screening, 12 diagnostic evaluation, 20 management, and 21 follow-up. These quality indicators provide evidence-explicit tools for measuring processes critical to ensuring high-quality supportive cancer care. Research is needed to characterize adherence to recommended practices and to evaluate the use of these measures in quality improvement efforts. [Copyright U.S. Cancer Pain Relief Committee. Published by Elsevier Inc.] JF - Journal of Pain and Symptom Management AU - Lorenz, Karl A AU - Dy, Sydney M AU - Naeim, Arash AU - Walling, Anne M AU - Sanati, Homayoon AU - Smith, Patricia AU - Shanman, Roberta AU - Roth, Carol P AU - Asch, Steven M AD - VA Greater Los Angeles Healthcare System, Los Angeles, California, USA karl.lorenz@med.va.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 943 EP - 964 PB - Elsevier, New York NY VL - 37 IS - 6 SN - 0885-3924, 0885-3924 KW - Symptoms KW - Care management KW - Pain KW - Cancer KW - Quality management KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57304591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pain+and+Symptom+Management&rft.atitle=Quality+Measures+for+Supportive+Cancer+Care%3A+The+Cancer+Quality-ASSIST+Project&rft.au=Lorenz%2C+Karl+A%3BDy%2C+Sydney+M%3BNaeim%2C+Arash%3BWalling%2C+Anne+M%3BSanati%2C+Homayoon%3BSmith%2C+Patricia%3BShanman%2C+Roberta%3BRoth%2C+Carol+P%3BAsch%2C+Steven+M&rft.aulast=Lorenz&rft.aufirst=Karl&rft.date=2009-06-01&rft.volume=37&rft.issue=6&rft.spage=943&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pain+and+Symptom+Management&rft.issn=08853924&rft_id=info:doi/10.1016%2Fj.jpainsymman.2008.05.018 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - JSPME2 N1 - SubjectsTermNotLitGenreText - Quality management; Cancer; Care management; Pain; Symptoms DO - http://dx.doi.org/10.1016/j.jpainsymman.2008.05.018 ER - TY - JOUR T1 - Staff's Attitudes Toward the Delivery of Tobacco Cessation Services in a Primarily Psychiatric Veterans Affairs Hospital AN - 57301460; 200918543 AB - To prepare for improving the delivery of cessation services in a primarily psychiatric Veterans Affairs (VA) hospital, the investigators surveyed (n = 150) and interviewed (n = 8) clinical and nonclinical staff to determine staff's characteristics associated with attitudes about providing cessation services and to seek suggestions about what would be important to include in a tobacco cessation program. Almost one third reported that they currently use tobacco products. Almost three quarters said that they felt that the VA should be doing more to assist patients to quit smoking, yet only approximately one quarter said that they personally provide cessation services. Over half felt moderately, very, or extremely confident in providing cessation services. Multivariate analyses showed that higher education and, surprisingly, not being a nurse were associated with feeling that it was important to provide cessation services. [Copyright Elsevier B.V.] JF - Archives of Psychiatric Nursing AU - Essenmacher, Carol AU - Karvonen-Gutierrez, Carrie AU - Lynch-Sauer, Judith AU - Duffy, Sonia A AD - Battle Creek VA Medical Center, Battle Creek, MI carol.essenmacher@va.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 231 EP - 242 PB - W.B. Saunders/Elsevier Ltd, The Netherlands VL - 23 IS - 3 SN - 0883-9417, 0883-9417 KW - Veterans KW - Smoking KW - Professional attitudes KW - Staff KW - Psychiatric hospitals KW - Cessation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57301460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Psychiatric+Nursing&rft.atitle=Staff%27s+Attitudes+Toward+the+Delivery+of+Tobacco+Cessation+Services+in+a+Primarily+Psychiatric+Veterans+Affairs+Hospital&rft.au=Essenmacher%2C+Carol%3BKarvonen-Gutierrez%2C+Carrie%3BLynch-Sauer%2C+Judith%3BDuffy%2C+Sonia+A&rft.aulast=Essenmacher&rft.aufirst=Carol&rft.date=2009-06-01&rft.volume=23&rft.issue=3&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Archives+of+Psychiatric+Nursing&rft.issn=08839417&rft_id=info:doi/10.1016%2Fj.apnu.2008.05.010 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cessation; Veterans; Professional attitudes; Smoking; Staff; Psychiatric hospitals DO - http://dx.doi.org/10.1016/j.apnu.2008.05.010 ER - TY - JOUR T1 - Influences of Comorbid Disorders on Personality Assessment Inventory Profiles in Women with Posttraumatic Stress Disorder AN - 57300735; 200918476 AB - The present study describes Personality Assessment Inventory (PAI) profiles for women with posttraumatic stress disorder (PTSD). Four groups of women were sampled: single Axis I diagnosis of PTSD; PTSD and major depressive disorder (MDD); PTSD, MDD, at least one other Axis I disorder; and controls with no Axis I disorder. Higher comorbidity rates were associated with higher mean profile elevations and broader range of endorsed symptoms. The group with the highest rate of comorbidity produced profiles most similar to previously published reports of patients with PTSD. This is in contrast to women with a single diagnosis of PTSD, who produced relative mean elevations only on subscales measuring distress caused by trauma and physiological symptoms of depression. Thus, published profiles may be more reflective of PTSD with comorbidity than a single diagnosis of PTSD. Adapted from the source document. JF - Journal of Psychopathology and Behavioral Assessment AU - Drury, Pamela AU - Calhoun, Patrick S AU - Boggs, Christina AU - Araujo, Gustavo AU - Dennis, Michelle F AU - Beckham, Jean C AD - Durham Veterans Affairs Medical Center, 116B, 508 Fulton Street, Durham, NC 27705, USA Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 119 EP - 128 PB - Springer, Dordrecht, The Netherlands VL - 31 IS - 2 SN - 0882-2689, 0882-2689 KW - Depressive personality disorders KW - Diagnosis KW - Posttraumatic stress disorder KW - Women KW - Personality tests KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57300735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychopathology+and+Behavioral+Assessment&rft.atitle=Influences+of+Comorbid+Disorders+on+Personality+Assessment+Inventory+Profiles+in+Women+with+Posttraumatic+Stress+Disorder&rft.au=Drury%2C+Pamela%3BCalhoun%2C+Patrick+S%3BBoggs%2C+Christina%3BAraujo%2C+Gustavo%3BDennis%2C+Michelle+F%3BBeckham%2C+Jean+C&rft.aulast=Drury&rft.aufirst=Pamela&rft.date=2009-06-01&rft.volume=31&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychopathology+and+Behavioral+Assessment&rft.issn=08822689&rft_id=info:doi/10.1007%2Fs10862-008-9101-5 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - JPBAEB N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Personality tests; Comorbidity; Diagnosis; Depressive personality disorders; Women DO - http://dx.doi.org/10.1007/s10862-008-9101-5 ER - TY - JOUR T1 - Role of Class A Penicillin-Binding Proteins in the Expression of ?-Lactam Resistance in Enterococcus faecium AN - 21325886; 11916757 AB - Peptidoglycan is polymerized by monofunctional D,D-transpeptidases belonging to class B penicillin-binding proteins (PBPs) and monofunctional glycosyltransferases and by bifunctional enzymes that combine both activities (class A PBPs). Three genes encoding putative class A PBPs (pbpF, pbpZ, and ponA) were deleted from the chromosome of Enterococcus faecium D344R in all possible combinations in order to identify the glycosyltransferases that cooperate with low-affinity class B Pbp5 for synthesis of peptidoglycan in the presence of ?-lactam antibiotics. The viability of the triple mutant indicated that glycan strands can be polymerized independently from class A PBPs by an unknown glycosyltranferase. The susceptibility of the pbpF ponA mutant and triple mutants to extended spectrum cephalosporins (ceftriaxone and cefepime) identified either PbpF or PonA as essential partners of Pbp5 for peptidoglycan polymerization in the presence of the drugs. Mass spectrometry analysis of peptidoglycan structure showed that loss of PonA and PbpF activity led to a minor decrease in the extent of peptidoglycan cross-linking by the remaining PBPs without any detectable compensatory increase in the participation of the L,D-transpeptidase in peptidoglycan synthesis. Optical density measurements and electron microscopy analyses showed that the pbpF ponA mutant underwent increased stationary-phase autolysis compared to the parental strain. Unexpectedly, deletion of the class A pbp genes revealed dissociation between the expression of resistance to cephalosporins and penicillins, although the production of Pbp5 was required for resistance to both classes of drugs. Thus, susceptibility of Pbp5-mediated peptidoglycan cross-linking to different ?-lactam antibiotics differed as a function of its partner glycosyltransferase. JF - Journal of Bacteriology AU - Rice, Louis B AU - Carias, Lenore L AU - Rudin, Susan AU - Hutton, Rebecca AU - Marshall, Steven AU - Hassan, Medhat AU - Josseaume, Nathalie AU - Dubost, Lionel AU - Marie, Arul AU - Arthur, Michel AD - INSERM, U872, LRMA-Equipe 12, Paris, F-75006, France, louis.rice@va.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 3649 EP - 3656 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 11 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Cephalosporins KW - Polymerization KW - Bifunctional enzymes KW - peptidoglycans KW - Antibiotics KW - penicillin-binding protein KW - Ceftriaxone KW - Polysaccharides KW - Mass spectroscopy KW - Penicillin KW - Enterococcus faecium KW - Glycosyltransferase KW - Chromosomes KW - Cefepime KW - Autolysis KW - Optical density KW - Drugs KW - Electron microscopy KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21325886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Role+of+Class+A+Penicillin-Binding+Proteins+in+the+Expression+of+%3F-Lactam+Resistance+in+Enterococcus+faecium&rft.au=Rice%2C+Louis+B%3BCarias%2C+Lenore+L%3BRudin%2C+Susan%3BHutton%2C+Rebecca%3BMarshall%2C+Steven%3BHassan%2C+Medhat%3BJosseaume%2C+Nathalie%3BDubost%2C+Lionel%3BMarie%2C+Arul%3BArthur%2C+Michel&rft.aulast=Rice&rft.aufirst=Louis&rft.date=2009-06-01&rft.volume=191&rft.issue=11&rft.spage=3649&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01834-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 20 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Cephalosporins; Polymerization; peptidoglycans; Bifunctional enzymes; penicillin-binding protein; Antibiotics; Ceftriaxone; Polysaccharides; Penicillin; Mass spectroscopy; Glycosyltransferase; Chromosomes; Cefepime; Optical density; Autolysis; Drugs; Electron microscopy; Enterococcus faecium DO - http://dx.doi.org/10.1128/JB.01834-08 ER - TY - JOUR T1 - Administrative Delays and Chronic Disability in Patients With Acute Occupational Low Back Injury AN - 20752089; 10191547 AB - Objectives: This study assessed whether an organizational factor, delays to claim acceptance or administrative delays, had an influence on outcomes for individuals with acute back injuries in the workers' compensation system. Methods: Multivariate logistic regression was used to test whether individuals who experienced administrative delays were more likely to develop chronic disability than those who did not experience delays. Results: Beyond the first 2 weeks, each interval of administrative delay was associated with increased odds of developing chronic disability. Injury severity, physician experience and weeks to medical treatment were additionally very strong predictors for the development of chronic disability. Conclusions: Insurers, employers, and policy makers can significantly reduce chronic disability if controls are adopted to reduce administrative and treatment delays and to direct workers to experienced clinicians. JF - Journal of Occupational and Environmental Medicine AU - Sinnott, P AD - Department of Veterans Affairs Health Economics Resource Center, 795 Willow Road, 152-MPD Menlo Park, CA 94025, USA, Patricia.Sinnott@va.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 690 EP - 699 VL - 51 IS - 6 SN - 1076-2752, 1076-2752 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - workers' compensation KW - Workers KW - disabilities KW - Injuries KW - Medical treatment KW - X 24310:Pharmaceuticals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20752089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Administrative+Delays+and+Chronic+Disability+in+Patients+With+Acute+Occupational+Low+Back+Injury&rft.au=Sinnott%2C+P&rft.aulast=Sinnott&rft.aufirst=P&rft.date=2009-06-01&rft.volume=51&rft.issue=6&rft.spage=690&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181a033b5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Workers; Injuries; workers' compensation; disabilities; Medical treatment DO - http://dx.doi.org/10.1097/JOM.0b013e3181a033b5 ER - TY - JOUR T1 - Transient suppression of heart rate complexity in concussed athletes AN - 20675045; 9431215 AB - Heart rate variability (HRV) and complexity (HRC) were calculated at rest and during an isometric hand grip test (IHGT) within 48-hours (48 h) and two weeks (Week Two) of a concussion in athletes (CG) and control subjects. No differences were present at rest or in HRV during IGHT. HRC was significantly lower in the CG compared to controls at 48 h during IHGT. In CG at Week Two during IHGT, HRC was significantly greater than 48 h observations and not significantly different than controls. The findings suggest that HRC may have utility in detecting efferent cardiac autonomic anomalies within two weeks of concussion. JF - Autonomic Neuroscience: Basic and Clinical AU - La Fountaine, Michael F AU - Heffernan, Kevin S AU - Gossett, James D AU - Bauman, William A AU - De Meersman, Ronald E AD - Center of Excellence on the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, NY, USA, Michael.LaFountaine@va.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 101 EP - 103 PB - Elsevier BV VL - 148 IS - 1-2 SN - 1566-0702, 1566-0702 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Mild traumatic brain injury KW - Concussion KW - Autonomic nervous system KW - Approximate entropy KW - Heart rate complexity. KW - Heart KW - Hands KW - concussion KW - Heart rate KW - Hand KW - Observation KW - Nervous system KW - Isometric KW - Rest KW - Isometrics KW - Athletes KW - PE 090:Sports Medicine & Exercise Sport Science KW - N3 11150:General and miscellaneous topics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20675045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Autonomic+Neuroscience%3A+Basic+and+Clinical&rft.atitle=Transient+suppression+of+heart+rate+complexity+in+concussed+athletes&rft.au=La+Fountaine%2C+Michael+F%3BHeffernan%2C+Kevin+S%3BGossett%2C+James+D%3BBauman%2C+William+A%3BDe+Meersman%2C+Ronald+E&rft.aulast=La+Fountaine&rft.aufirst=Michael&rft.date=2009-06-01&rft.volume=148&rft.issue=1-2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Autonomic+Neuroscience%3A+Basic+and+Clinical&rft.issn=15660702&rft_id=info:doi/10.1016%2Fj.autneu.2009.03.001 LA - English DB - Physical Education Index N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hands; Heart rate; Rest; Isometrics; Observation; Concussion; Athletes; Heart; Nervous system; Autonomic nervous system; concussion; Isometric; Hand DO - http://dx.doi.org/10.1016/j.autneu.2009.03.001 ER - TY - JOUR T1 - Herpes Zoster Risk Factors in a National Cohort of Veterans with Rheumatoid Arthritis AN - 21273823; 11848883 AB - Background._Herpes zoster occurs more commonly In patients taking immunosuppressive medications, although the risk associated with different medications is poorly understood. Methods._We conducted a retrospective cohort study Involving 20,357 patients who were followed in the Veterans Affairs healthcare system and treated for rheumatoid arthritis from October 1998 through June 2005. Cox proportional hazards regression was used to determine risk factors for herpes zoster and herpes zoster-free survival. Chart review was performed to validate the diagnosis of herpes zoster. Results._The incidence of herpes zoster was 9.96 episodes per 1000 patient-years. In time-to-event analysis, patients receiving medications used to treat mild rheumatoid arthritis were less likely to have an episode of herpes zoster than patients receiving medications used to treat moderate and severe rheumatoid arthritis (P < .001). Independent risk factors for herpes zoster Included older age, prednisone use, medications used to treat moderate and severe rheumatoid arthritis, malignancy, chronic lung disease, renal failure, and liver disease. Among patients receiving tumor necrosis factor-a antagonists, etanercept (hazard ratio, 0.62) and adalimumab (hazard ratio, 0.53) were associated with a lower risk of herpes zoster. There was excellent agreement between the International Classification of Diseases, Version 9, Clinical Modification diagnosis of herpes zoster and diagnosis by chart review (k = 0.92). Conclusions._Risk factors for herpes zoster included older age, prednisone use, medications used to treat moderate and severe rheumatoid arthritis, and several comorbid medical conditions. These results demonstrate that the Department of Veterans Affairs' national administrative databases can be used to study rare adverse drug events. JF - Clinical Infectious Diseases AU - McDonald, J R AU - Zeringue, AL AU - Caplan, L AU - Ranganathan, P AU - Xian, H AU - Burroughs, TE AU - Fraser, V J AU - Cunningham, F AU - Eisen, SA AD - St. Louis Veterans Affairs Medical Center, St. Louis, Missouri, USA, Jay.McDonald1@va.gov Y1 - 2009/05/15/ PY - 2009 DA - 2009 May 15 SP - 1364 EP - 1371 VL - 48 IS - 10 SN - 1058-4838, 1058-4838 KW - Virology & AIDS Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Prednisone KW - Herpes simplex KW - Malignancy KW - Classification KW - Geriatrics KW - Liver diseases KW - Monoclonal antibodies KW - Lung diseases KW - Databases KW - Rheumatoid arthritis KW - Herpes zoster KW - Survival KW - Antagonists KW - Risk factors KW - Drugs KW - Renal failure KW - Tumor necrosis factor-a KW - etanercept KW - Tumor necrosis factor-^a KW - K 03400:Human Diseases KW - J 02400:Human Diseases KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21273823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Herpes+Zoster+Risk+Factors+in+a+National+Cohort+of+Veterans+with+Rheumatoid+Arthritis&rft.au=McDonald%2C+J+R%3BZeringue%2C+AL%3BCaplan%2C+L%3BRanganathan%2C+P%3BXian%2C+H%3BBurroughs%2C+TE%3BFraser%2C+V+J%3BCunningham%2C+F%3BEisen%2C+SA&rft.aulast=McDonald&rft.aufirst=J&rft.date=2009-05-15&rft.volume=48&rft.issue=10&rft.spage=1364&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F598331 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Herpes zoster; Rheumatoid arthritis; Risk factors; Geriatrics; Prednisone; Liver diseases; Renal failure; Drugs; Tumor necrosis factor-a; etanercept; Monoclonal antibodies; Classification; Herpes simplex; Malignancy; Lung diseases; Antagonists; Survival; Databases; Tumor necrosis factor-^a DO - http://dx.doi.org/10.1086/598331 ER - TY - JOUR T1 - Immune responses to methamphetamine by active immunization with peptide-based, molecular adjuvant-containing vaccines. AN - 67227249; 19428909 AB - Vaccines to methamphetamine (meth) were designed by covalently attaching a meth hapten (METH) to peptide constructs that contained a conformationally biased, response-selective molecular adjuvant, YSFKPMPLaR (EP54). Rats immunized with EP54-containing meth vaccines generated serum antibody titers to authentic meth, an immune outcome that altered meth self-administration. Immunization increased meth self-administration suggesting pharmacokinetic antagonism. The ability of immune sera to bind a METH-modified target protein dramatically decreased during and shortly after the meth self-administration assay, suggesting effective sequestration of free meth. However, the binding ability of immune sera to the METH-modified target protein was recovered 34 days after meth-free clearance time. JF - Vaccine AU - Duryee, Michael J AU - Bevins, Rick A AU - Reichel, Carmela M AU - Murray, Jennifer E AU - Dong, Yuxiang AU - Thiele, Geoffrey M AU - Sanderson, Sam D AD - Experimental Immunology Laboratory, Omaha Veterans Administration Medical Center, Research Services 151, Omaha, NE 68105, USA. Y1 - 2009/05/14/ PY - 2009 DA - 2009 May 14 SP - 2981 EP - 2988 VL - 27 IS - 22 SN - 0264-410X, 0264-410X KW - Adjuvants, Immunologic KW - 0 KW - Antibodies KW - Haptens KW - Peptide Fragments KW - Vaccines, Subunit KW - complement C5a, (65-74), Tyr(65)-Phe(67)-Pro(69,71)-Ala(73)- KW - Methamphetamine KW - 44RAL3456C KW - Complement C5a KW - 80295-54-1 KW - Index Medicus KW - Rats KW - Complement C5a -- pharmacology KW - Animals KW - Adjuvants, Immunologic -- administration & dosage KW - Self Administration KW - Antibodies -- blood KW - Peptide Fragments -- pharmacology KW - Adjuvants, Immunologic -- pharmacology KW - Peptide Fragments -- administration & dosage KW - Complement C5a -- administration & dosage KW - Male KW - Amphetamine-Related Disorders -- prevention & control KW - Methamphetamine -- immunology KW - Haptens -- immunology KW - Vaccines, Subunit -- immunology KW - Amphetamine-Related Disorders -- immunology KW - Substance-Related Disorders -- immunology KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67227249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Immune+responses+to+methamphetamine+by+active+immunization+with+peptide-based%2C+molecular+adjuvant-containing+vaccines.&rft.au=Simpson%2C+Tracy%3BJakupcak%2C+Matthew%3BLuterek%2C+Jane+A&rft.aulast=Simpson&rft.aufirst=Tracy&rft.date=2006-08-01&rft.volume=19&rft.issue=4&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Journal+of+traumatic+stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-12 N1 - Date created - 2009-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.vaccine.2009.02.105 ER - TY - CPAPER T1 - Morphological Changes of Corneal Endothelial Cells in Patients With Blast- Induced Traumatic Brain Injury T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42574873; 5475375 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Zumhagen, L AU - Cockerham, G C Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Brain KW - Traumatic brain injury KW - Endothelial cells KW - Cornea KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42574873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Morphological+Changes+of+Corneal+Endothelial+Cells+in+Patients+With+Blast-+Induced+Traumatic+Brain+Injury&rft.au=Zumhagen%2C+L%3BCockerham%2C+G+C&rft.aulast=Zumhagen&rft.aufirst=L&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ocular and Adnexal Damage in Veterans With Combat Blast-Induced Traumatic Brain Injury T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42570564; 5478975 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Cockerham, G AU - Rice, T AU - Hewes, E AU - Cockerham, K AU - Wang, G AU - Glynn-Milley, C Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Brain KW - Traumatic brain injury KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42570564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Ocular+and+Adnexal+Damage+in+Veterans+With+Combat+Blast-Induced+Traumatic+Brain+Injury&rft.au=Cockerham%2C+G%3BRice%2C+T%3BHewes%2C+E%3BCockerham%2C+K%3BWang%2C+G%3BGlynn-Milley%2C+C&rft.aulast=Cockerham&rft.aufirst=G&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Expectations, prefitting counseling, and hearing aid outcome. AN - 85382022; pmid-19585963 AB - Data suggest that having high expectations about hearing aids results in better overall outcome. However, some have postulated that excessively high expectations will result in disappointment and thus poor outcome. It has been suggested that counseling patients with unrealistic expectations about hearing aids prior to fitting may be beneficial. Data, however, are mixed as to the effectiveness of such counseling, in terms of both changes in expectations and final outcome.The primary purpose of this study was to determine whether supplementing prefitting counseling with demonstration of real-world listening can (1) alter expectations of new hearing aid users and (2) increase satisfaction over verbal-only counseling. Secondary goals of the study were to examine (1) the relationship between prefitting expectations and postfitting outcome, and (2) the effect of hearing aid fine-tuning on hearing aid outcome.Sixty new hearing aid users were fitted binaurally with Beltone Oria behind-the-ear digital hearing aids. Forty participants received prefitting counseling and demonstration of listening situations with the Beltone AVE (Audio Verification Environment) system; 20 received prefitting counseling without a demonstration of listening situations. Hearing aid expectations were measured at initial contact and following prefitting counseling. Reported hearing aid outcome was measured after eight to ten weeks of hearing aid use.Sixty new hearing aid users aged between 55 and 81 years with symmetrical sensorineural hearing loss.Participants were randomly assigned to one of three experimental groups, between which the prefitting counseling and follow-up differed: Group 1 received prefitting counseling in combination with demonstration of listening situations. Additionally, if the participant had complaints about sound quality at the follow-up visit, the hearing aids were fine-tuned using the Beltone AVE system. Group 2 received prefitting counseling in combination with demonstration of listening situations with the Beltone AVE system, but no fine-tuning was provided at follow-up. Group 3 received prefitting hearing aid counseling that did not include demonstration of listening, and the hearing aids were not fine-tuned at the follow-up appointment.The results showed that prefitting hearing aid counseling had small but significant effects on expectations. The two forms of counseling did not differ in their effectiveness at changing expectations; however, anecdotally, we learned from many participants that that they enjoyed listening to the auditory demonstrations and that they found them to be an interesting listening exercise. The data also show that positive expectations result in more positive outcome and that hearing aid fine-tuning is beneficial to the user.We conclude that prefitting counseling can be advantageous to hearing aid outcome and recommend the addition of prefitting counseling to address expectations associated with quality of life and self-image. The data emphasize the need to address unrealistic expectations prior to fitting hearing aids cautiously, so as not to decrease expectations to the extent of discouraging and demotivating the patient. Data also show that positive expectations regarding the impact hearing aids will have on psychosocial well-being are important for successful hearing aid outcome. JF - Journal of the American Academy of Audiology AU - Saunders, Gabrielle H AU - Lewis, M Samantha AU - Forsline, Anna AD - National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Portland, OR 97207, USA. Gabrielle.Saunders@va.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 320 EP - 334 VL - 20 IS - 5 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - Audiometry, Pure-Tone KW - *Counseling: methods KW - Female KW - Follow-Up Studies KW - *Hearing Aids KW - Hearing Loss, Sensorineural: physiopathology KW - *Hearing Loss, Sensorineural: rehabilitation KW - Humans KW - Male KW - Middle Aged KW - *Patient Satisfaction KW - *Prosthesis Fitting: methods KW - *Speech Perception: physiology KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85382022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Expectations%2C+prefitting+counseling%2C+and+hearing+aid+outcome.&rft.au=Saunders%2C+Gabrielle+H%3BLewis%2C+M+Samantha%3BForsline%2C+Anna&rft.aulast=Saunders&rft.aufirst=Gabrielle&rft.date=2009-05-01&rft.volume=20&rft.issue=5&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Oseltamivir for treatment and prophylaxis of Influenza Infection AN - 744692842; 13097675 AB - Background: Influenza infection is a global problem affecting millions of people worldwide, despite efficacious vaccines. Treatment and prophylaxis against influenza have been successful using antiviral medications such as adamantanes and neuraminidase inhibitors. Objective: To review the antiviral agents and specifically the neuraminidase inhibitor, oseltamivir, for use in treatment and prophylaxis of influenza infection. Methods: This review focuses on published literature regarding the clinical use of oseltamivir, as well as discussing emerging threats such as avian influenza, antiviral resistance, and strategies such as combination antiviral treatment to mitigate these threats. Results: Oseltamivir is effective in reducing symptom burden in those with influenza A or B infection, and is preventative against developing infection after exposure. Emergence of naturally occurring or post-treatment oseltamivir-resistant influenza as well as an avian influenza pandemic may limit its future use as a monotherapeutic antiviral treatment agent. JF - Expert Opinion on Drug Safety AU - Schirmer, P AU - Holodniy, M AD - Stanford University, VA Palo Alto Health Care System, Division of Infectious Diseases & Geographic Medicine, 3801 Miranda Avenue (132), Palo Alto, CA 94304, USA, mark.holodniy@va.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 357 EP - 371 VL - 8 IS - 3 SN - 1474-0338, 1474-0338 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - vaccines KW - antiviral agents KW - Influenza A KW - Exo-a-sialidase KW - Infection KW - influenza KW - Oseltamivir KW - Fowl plague KW - pandemics KW - Antiviral agents KW - Reviews KW - infection KW - Prophylaxis KW - Vaccines KW - Drugs KW - A 01340:Antibiotics & Antimicrobials KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744692842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Drug+Safety&rft.atitle=Oseltamivir+for+treatment+and+prophylaxis+of+Influenza+Infection&rft.au=Schirmer%2C+P%3BHolodniy%2C+M&rft.aulast=Schirmer&rft.aufirst=P&rft.date=2009-05-01&rft.volume=8&rft.issue=3&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Expert+Opinion+on+Drug+Safety&rft.issn=14740338&rft_id=info:doi/10.1517%2F14740330902840519 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Fowl plague; pandemics; Antiviral agents; Reviews; Influenza A; Exo-a-sialidase; Prophylaxis; Vaccines; Infection; Oseltamivir; vaccines; antiviral agents; infection; Drugs; influenza DO - http://dx.doi.org/10.1517/14740330902840519 ER - TY - JOUR T1 - Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites. AN - 742781397; pmid-19337238 AB - OBJECTIVES: Spontaneous bacterial peritonitis (SBP) is a frequent complication of cirrhosis. Bacterial contamination of ascites fluid leading to SBP is caused by bacterial translocation with subsequent bacteremia. Proton pump inhibitors (PPIs) suppress gastric acid secretion, allowing bacterial colonization of the upper gastrointestinal tract, and may predispose to bacterial overgrowth and translocation. The aim of this study was to determine whether PPI use in cirrhotics with ascites is associated with SBP. METHODS: A retrospective case-control study was performed. Seventy cirrhotics admitted with paracentesis-proven SBP between 2002 and 2007 were matched 1:1 (for age and Child's class) with comparable cirrhotics with ascites who were admitted for conditions other than SBP. We excluded patients on chronic antibiotic prophylaxis or with antecedent gastrointestinal bleeding. Outpatient PPI use at the time of admission was compared between groups, and the effect of covariates was analyzed. RESULTS: Patients with SBP had a significantly higher rate of prehospital PPI use (69%) compared with ascitic cirrhotics hospitalized without SBP (31%, P = 0.0001). There was no significant difference in demographics, diabetes, etiology, or survival between groups. On multivariate analysis, PPI use was independently associated with SBP (odds ratio (OR) 4.31, confidence interval (CI) 1.34-11.7), and ascitic fluid protein was protective (OR 0.1, CI 0.03-0.25). In total, 47% of cirrhotic patients receiving PPI in this study had no documented indication for PPI treatment. CONCLUSIONS: PPI therapy is associated with SBP in patients with advanced cirrhosis. Prospective studies are needed to determine whether PPI avoidance can reduce the incidence of SBP and improve outcomes. JF - The American journal of gastroenterology AU - Bajaj, Jasmohan S AU - Zadvornova, Yelena AU - Heuman, Douglas M AU - Hafeezullah, Muhammad AU - Hoffmann, Raymond G AU - Sanyal, Arun J AU - Saeian, Kia AD - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, McGuire VA Medical Center, Virginia Commonwealth University, Richmond, Virginia 23221, USA. jasmohan.bajaj@va.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1130 EP - 1134 VL - 104 IS - 5 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Probability KW - Odds Ratio KW - Gram-Negative Bacterial Infections -- diagnosis KW - Humans KW - Gram-Positive Bacterial Infections -- epidemiology KW - Retrospective Studies KW - Aged KW - Gram-Negative Bacterial Infections -- epidemiology KW - Comorbidity KW - Gram-Positive Bacterial Infections -- diagnosis KW - Risk Assessment KW - Proton Pump Inhibitors -- adverse effects KW - Adult KW - Male KW - Survival Analysis KW - Severity of Illness Index KW - Liver Cirrhosis -- diagnosis KW - Liver Cirrhosis -- drug therapy KW - Prognosis KW - Age Distribution KW - Logistic Models KW - Case-Control Studies KW - Confidence Intervals KW - Incidence KW - Middle Aged KW - Liver Cirrhosis -- epidemiology KW - Proton Pump Inhibitors -- therapeutic use KW - Sex Distribution KW - Female KW - Peritonitis -- epidemiology KW - Peritonitis -- microbiology KW - Bacteremia -- microbiology KW - Bacteremia -- epidemiology KW - Ascites -- epidemiology KW - Ascites -- microbiology KW - Peritonitis -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742781397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Association+of+proton+pump+inhibitor+therapy+with+spontaneous+bacterial+peritonitis+in+cirrhotic+patients+with+ascites.&rft.au=Bajaj%2C+Jasmohan+S%3BZadvornova%2C+Yelena%3BHeuman%2C+Douglas+M%3BHafeezullah%2C+Muhammad%3BHoffmann%2C+Raymond+G%3BSanyal%2C+Arun+J%3BSaeian%2C+Kia&rft.aulast=Bajaj&rft.aufirst=Jasmohan&rft.date=2009-05-01&rft.volume=104&rft.issue=5&rft.spage=1130&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - When We Research 'Conditions-Treatments,' Is There a Misnomer? AN - 742721517; 201011528 AB - Abstract not available. JF - American Psychologist AU - Raps, Charles S AD - VA Medical Center, Northport, New York charles.raps@va.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 275 EP - 276 PB - American Psychological Association, Washington DC VL - 64 IS - 4 SN - 0003-066X, 0003-066X KW - Attitudes KW - Psychology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742721517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Psychologist&rft.atitle=When+We+Research+%27Conditions-Treatments%2C%27+Is+There+a+Misnomer%3F&rft.au=Raps%2C+Charles+S&rft.aulast=Raps&rft.aufirst=Charles&rft.date=2009-05-01&rft.volume=64&rft.issue=4&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=American+Psychologist&rft.issn=0003066X&rft_id=info:doi/10.1037%2Fa0015344 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Psychology; Attitudes DO - http://dx.doi.org/10.1037/a0015344 ER - TY - JOUR T1 - Correlation of iron and colon adenomas. AN - 733095312; 19144479 AB - Better colon cancer screening guidelines are needed. This study was conducted to explore the relationship between serum transferrin saturation (as iron is a potential carcinogen) and presence of colon adenomas. This may aid to evolve better colon cancer screening guidelines. This study is a retrospective review of computer records. Patients who had colonoscopy and iron studies done between May 1996 and December 2003 were included in the study. The adjusted odds ratio, derived from multiple logistic regression analysis, was used to measure the association between transferrin saturation and colon adenomas. Complete data were available for 124 subjects. The adjusted odds ratio, for predicting the presence of polyp in those patients with transferrin saturation above the median was 10.9 (CI 4.0-29.5, P<0.001). A one percent increase in transferrin saturation was associated with a 1.07 increase the odds of adenoma (CI 1.03-1.11, P<0.001). Iron levels are directly linked to presence of colon polyps, and might help in evolving better screening guidelines. JF - Gastroenterologie clinique et biologique AU - Muthunayagam, N P AU - Rohrer, J E AU - Wright, S E AD - Department of Internal Medicine, Amarillo Veterans Administration Health Care System, 6010, Amarillo Boulevard West, Amarillo, TX 79106, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 435 EP - 440 VL - 33 IS - 5 SN - 0399-8320, 0399-8320 KW - Transferrin KW - 0 KW - Index Medicus KW - Humans KW - Retrospective Studies KW - Aged KW - Male KW - Female KW - Iron Overload -- complications KW - Colonic Neoplasms -- etiology KW - Adenoma -- etiology KW - Transferrin -- analysis KW - Adenoma -- blood KW - Colonic Neoplasms -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733095312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterologie+clinique+et+biologique&rft.atitle=Correlation+of+iron+and+colon+adenomas.&rft.au=Muthunayagam%2C+N+P%3BRohrer%2C+J+E%3BWright%2C+S+E&rft.aulast=Muthunayagam&rft.aufirst=N&rft.date=2009-05-01&rft.volume=33&rft.issue=5&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Gastroenterologie+clinique+et+biologique&rft.issn=03998320&rft_id=info:doi/10.1016%2Fj.gcb.2008.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-02 N1 - Date created - 2009-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.gcb.2008.08.004 ER - TY - JOUR T1 - Polypharmacy in the elderly: focus on drug interactions and adherence in hypertension. AN - 67420486; 19555869 AB - Polypharmacy is highly prevalent in the elderly due to an increased number of co-morbid disease states that accompany aging. Hypertension is one common disease that can be challenging to treat in the elderly due to the body's physiologic changes, potential risks for side effects, medication interactions, and decreased medication adherence. A thorough medication assessment for each patient is essential when determining pharmacotherapeutic options in the elderly. JF - Clinics in geriatric medicine AU - Cooney, Danielle AU - Pascuzzi, Kristina AD - Department of Pharmacy, Louis Stokes Veterans Affairs Medical Center, Pharmacy Service (119W), 10701 East Blvd, Cleveland, OH 44106, USA. danielle.corwin@va.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 221 EP - 233 VL - 25 IS - 2 KW - Antihypertensive Agents KW - 0 KW - Index Medicus KW - Aging -- physiology KW - Age Factors KW - Aged, 80 and over KW - Risk Factors KW - Humans KW - Aged KW - Male KW - Female KW - Prevalence KW - Hypertension -- physiopathology KW - Antihypertensive Agents -- adverse effects KW - Polypharmacy KW - Antihypertensive Agents -- metabolism KW - Medication Adherence -- psychology KW - Drug Interactions -- physiology KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67420486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+geriatric+medicine&rft.atitle=Polypharmacy+in+the+elderly%3A+focus+on+drug+interactions+and+adherence+in+hypertension.&rft.au=Cooney%2C+Danielle%3BPascuzzi%2C+Kristina&rft.aulast=Cooney&rft.aufirst=Danielle&rft.date=2009-05-01&rft.volume=25&rft.issue=2&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Clinics+in+geriatric+medicine&rft.issn=1879-8853&rft_id=info:doi/10.1016%2Fj.cger.2009.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-09 N1 - Date created - 2009-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cger.2009.01.005 ER - TY - JOUR T1 - Benefits of retention in methadone maintenance and chronic medical conditions as risk factors for premature death among older heroin addicts. AN - 67270127; 19461397 AB - Methadone maintenance treatment reduces rates of premature mortality in heroin addicts. However, few published studies have addressed the effectiveness of treatment, mortality rates, or causes of death in older (geriatric) patients maintained on methadone. Identifying risk factors for premature mortality and potential targets for early intervention may reduce rates of premature mortality in older patients maintained on methadone. We conducted a retrospective chart review for patients enrolled in the methadone maintenance program at the Atlanta Veterans Affairs Medical Center. We reviewed the charts of 91 patients and collected the following information: demographics (age, gender, marital status, and race); composite score at admission on the Addiction Severity Index (ASI); most recent ASI score for alcohol use, drug use, and medical, psychiatric, family, legal, and employment problems; results of urine drug screens for opiates, cocaine, and benzodiazepines (first 4 screens after admission and last 4 screens); dose and duration of methadone treatment; HIV and hepatitis B and C status; tobacco smoking; presence of diabetes mellitus, hypertension, heart disease, chronic obstructive pulmonary disease, or cancer; history of intravenous drug use; and missed primary care appointments (last five appointments). A statistically significant association was found between diabetes mellitus and between liver and gastrointestinal cancer and premature mortality in this sample of older patients maintained on methadone (OR=30.79, p=0.008 for diabetes mellitus; OR=19.91, p=0.017 for cancer). Patients who remained in treatment showed statistically significant improvement in ASI scores for problems related to drug use and for psychiatric, medical, and legal problems. They showed a nonsignificant trend toward reduction of problems associated with alcohol use. The group of patients who dropped out of methadone treatment did not show statistically significant improvement on any area of the ASI except family problems. The group who remained in treatment also showed a statistically significant reduction in drug use when results of the first four and last four urine drug screens for opiates, cocaine, and benzodiazepines were compared (p<0.0001 for opiates and cocaine, p=0.02 for benzodiazepines).On the other hand, the group who dropped out of methadone treatment did not show any statistically significant reduction in drug use based on urine screens (p=0.05 for opiates, p=0.38 for cocaine, and p=0.53 for benzodiazepines). The results presented here suggest potential targets for intervention related to lifestyle risk factors and comorbid medical conditions, such as nicotine dependence and diabetes mellitus, that may have the potential to improve health outcomes for older patients with opioid dependence. JF - Journal of psychiatric practice AU - Fareed, Ayman AU - Casarella, Jennifer AU - Amar, Richard AU - Vayalapalli, Sreedevi AU - Drexler, Karen AD - Department of Psychiatry, Emory University, School of Medicine, USA. ayman.fareed@va.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 227 EP - 234 VL - 15 IS - 3 KW - Narcotics KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Age Factors KW - Humans KW - Liver Neoplasms -- mortality KW - Retrospective Studies KW - Aged KW - Diabetes Mellitus -- mortality KW - Comorbidity KW - Life Style KW - Substance Abuse Detection KW - Risk Factors KW - Treatment Outcome KW - Gastrointestinal Neoplasms -- mortality KW - Middle Aged KW - Long-Term Care KW - Georgia KW - Female KW - Male KW - Methadone -- adverse effects KW - Chronic Disease -- mortality KW - Narcotics -- adverse effects KW - Narcotics -- administration & dosage KW - Heroin Dependence -- rehabilitation KW - Methadone -- administration & dosage KW - Heroin Dependence -- mortality KW - Cause of Death UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67270127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychiatric+practice&rft.atitle=Benefits+of+retention+in+methadone+maintenance+and+chronic+medical+conditions+as+risk+factors+for+premature+death+among+older+heroin+addicts.&rft.au=Fareed%2C+Ayman%3BCasarella%2C+Jennifer%3BAmar%2C+Richard%3BVayalapalli%2C+Sreedevi%3BDrexler%2C+Karen&rft.aulast=Fareed&rft.aufirst=Ayman&rft.date=2009-05-01&rft.volume=15&rft.issue=3&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychiatric+practice&rft.issn=1538-1145&rft_id=info:doi/10.1097%2F01.pra.0000351884.83377.e2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-04 N1 - Date created - 2009-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/01.pra.0000351884.83377.e2 ER - TY - JOUR T1 - 10 questions about 4-aminopyridine and the treatment of multiple sclerosis. AN - 67222810; 19430274 JF - The neurologist AU - Bever, Christopher T AD - Research and Neurology Services, VA Maryland Healthcare System, VA Multiple Sclerosis Center of Excellence-East, Baltimore, Maryland, USA. Christopher.Bever@va.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 161 EP - 162 VL - 15 IS - 3 KW - Potassium Channel Blockers KW - 0 KW - 4-Aminopyridine KW - BH3B64OKL9 KW - Index Medicus KW - United States KW - Drug Approval -- legislation & jurisprudence KW - United States Food and Drug Administration KW - Humans KW - Clinical Trials as Topic KW - 4-Aminopyridine -- adverse effects KW - Multiple Sclerosis -- drug therapy KW - Potassium Channel Blockers -- adverse effects KW - 4-Aminopyridine -- therapeutic use KW - Potassium Channel Blockers -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67222810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+neurologist&rft.atitle=10+questions+about+4-aminopyridine+and+the+treatment+of+multiple+sclerosis.&rft.au=Bever%2C+Christopher+T&rft.aulast=Bever&rft.aufirst=Christopher&rft.date=2009-05-01&rft.volume=15&rft.issue=3&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=The+neurologist&rft.issn=2331-2637&rft_id=info:doi/10.1097%2FNRL.0b013e3181679be5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-07 N1 - Date created - 2009-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/NRL.0b013e3181679be5 ER - TY - JOUR T1 - Meta-analyses and the search for specific and common mediators of substance misuse intervention effects. AN - 67212423; 19413786 JF - Addiction (Abingdon, England) AU - Finney, John W AD - Center for Health Care Evaluation, VA Palo Alto HCS (152MPD), 795 Willow Road, Menlo Park, CA 94025, USA. john.finney@va.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 716 EP - 7; discussion 717-8 VL - 104 IS - 5 KW - Index Medicus KW - Review Literature as Topic KW - Interview, Psychological KW - Humans KW - Meta-Analysis as Topic KW - Motivation KW - Cognitive Therapy -- methods KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67212423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Meta-analyses+and+the+search+for+specific+and+common+mediators+of+substance+misuse+intervention+effects.&rft.au=Finney%2C+John+W&rft.aulast=Finney&rft.aufirst=John&rft.date=2009-05-01&rft.volume=104&rft.issue=5&rft.spage=716&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=1360-0443&rft_id=info:doi/10.1111%2Fj.1360-0443.2009.02572.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-30 N1 - Date created - 2009-05-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Addiction. 2009 May;104(5):705-15 [19413785] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1360-0443.2009.02572.x ER - TY - JOUR T1 - Discontinuing postmenopausal hormone therapy: an observational study of tapering versus quitting cold turkey: is there a difference in recurrence of menopausal symptoms? AN - 67210702; 19182695 AB - Because no current evidence-based guidelines for postmenopausal hormone therapy (HT) discontinuation strategies exist, we compared female veterans who tapered HT to those who stopped abruptly with regard to patient-specific health factors and recurrence of menopausal symptoms. We identified female veterans who used combined estrogen/medroxyprogesterone HT in 2001 using the VA Pharmacy Benefits Management database. We then randomly sorted and selected 4,000 women for a mailed invitation to participate in a HT survey. Women who agreed to participate were mailed the National Women Veterans Hormone Replacement Survey. Of 836 participants who discontinued HT, 75% stopped cold turkey and 25% tapered. In bivariate analysis, taperers were more likely to report higher incomes, less smoking, and more use of alternatives such as vitamin E, other dietary supplements, and exercise or yoga for menopausal symptoms. They also more frequently reported discussions of menopausal symptoms with providers and used HT for menopausal symptoms and had longer median years of HT (P 90% neurons) but not in mixed cultures (30% neurons plus other non-neuronal cells). Co-cultures of microglia on permeable transwell inserts above neuronal-enriched cultures blocked neuroprotection by EP1 antagonists. Incubation of microglia with neuronal-enriched cultures for 48 hours prior to NMDA challenge was sufficient to block neuroprotection by EP1 antagonists. The loss of neuroprotection by EP1 antagonists was accompanied by a decrease of neuronal EP1 expression in the nucleus in cultures with microglia present. These findings demonstrate microglial modulation of neuronal excitotoxicity through interaction with the EP1 receptor and may have important implications in vivo where microglia are associated with neuronal injury. JF - Journal of neuroinflammation AU - Carlson, Noel G AU - Rojas, Monica A AU - Black, John-David AU - Redd, Jonathan W AU - Hille, John AU - Hill, Kenneth E AU - Rose, John W AD - Geriatric Research Education and Clinical Center (GRECC), VASLCHCS, Salt Lake City, UT 84148, USA. noel.carlson@med.va.gov Y1 - 2009/02/17/ PY - 2009 DA - 2009 Feb 17 SP - 5 VL - 6 KW - Bridged Bicyclo Compounds KW - 0 KW - Caproates KW - Cyclooxygenase 2 Inhibitors KW - Excitatory Amino Acid Agonists KW - Hydrazines KW - Neuroprotective Agents KW - ONO 8711 KW - Oxazepines KW - Ptger1 protein, mouse KW - Receptors, Prostaglandin E KW - Receptors, Prostaglandin E, EP1 Subtype KW - SC 51089 KW - 146033-02-5 KW - N-Methylaspartate KW - 6384-92-5 KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Microscopy, Confocal KW - Animals KW - Cell Death -- physiology KW - Coculture Techniques KW - Dose-Response Relationship, Drug KW - Astrocytes -- physiology KW - Cyclooxygenase 2 Inhibitors -- pharmacology KW - Mice KW - Cell Death -- drug effects KW - Excitatory Amino Acid Agonists -- toxicity KW - Caproates -- pharmacology KW - Bridged Bicyclo Compounds -- pharmacology KW - Hydrazines -- pharmacology KW - Cells, Cultured KW - Dinoprostone -- metabolism KW - Oxazepines -- pharmacology KW - N-Methylaspartate -- toxicity KW - Receptors, Prostaglandin E -- metabolism KW - Receptors, Prostaglandin E -- antagonists & inhibitors KW - Microglia -- physiology KW - Neurons -- drug effects KW - Neurons -- physiology KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66985500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroinflammation&rft.atitle=Microglial+inhibition+of+neuroprotection+by+antagonists+of+the+EP1+prostaglandin+E2+receptor.&rft.au=Carlson%2C+Noel+G%3BRojas%2C+Monica+A%3BBlack%2C+John-David%3BRedd%2C+Jonathan+W%3BHille%2C+John%3BHill%2C+Kenneth+E%3BRose%2C+John+W&rft.aulast=Carlson&rft.aufirst=Noel&rft.date=2009-02-17&rft.volume=6&rft.issue=&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroinflammation&rft.issn=1742-2094&rft_id=info:doi/10.1186%2F1742-2094-6-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-14 N1 - Date created - 2009-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacol Ther. 2006 Nov;112(2):335-57 [16750270] Trends Pharmacol Sci. 2006 Sep;27(9):458-60 [16870271] Curr Med Chem. 2007;14(11):1189-97 [17504139] J Neurosci Res. 2007 Aug 15;85(11):2433-40 [17600836] J Neurosci Res. 2007 Nov 1;85(14):3109-17 [17868147] Neurobiol Dis. 2008 Mar;29(3):543-51 [18178094] Alcohol Clin Exp Res. 1999 Oct;23(10):1571-9 [10549987] J Cereb Blood Flow Metab. 1999 Nov;19(11):1213-9 [10566967] J Mol Med (Berl). 2000;78(1):3-13 [10759025] J Pharmacol Exp Ther. 2000 May;293(2):417-25 [10773011] Eur J Neurosci. 2001 Feb;13(3):569-75 [11168565] Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1294-9 [11158633] Arch Neurol. 2001 Apr;58(4):669-72 [11296002] Arch Neurol. 2001 Apr;58(4):672-4 [11296003] J Neurosci. 2001 Oct 15;21(20):8198-209 [11588192] J Neurosci Res. 2003 Jan 1;71(1):79-88 [12478616] Ann Neurol. 2003 Aug;54(2):155-62 [12891667] Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11712-7 [14504398] J Neurosci. 2004 Jan 7;24(1):257-68 [14715958] Ann Neurol. 2004 May;55(5):668-75 [15122707] Neurochem Int. 2004 Oct;45(5):713-9 [15234114] Pharmacol Ther. 2004 Aug;103(2):147-66 [15369681] N Engl J Med. 2004 Oct 21;351(17):1709-11 [15470192] N Engl J Med. 2004 Oct 21;351(17):1707-9 [15470193] Neurochem Int. 1994 Apr;24(4):395-8 [7914788] Brain Res. 1994 Nov 14;663(2):237-43 [7874506] Biochim Biophys Acta. 1995 May 11;1244(1):41-8 [7766667] J Med Chem. 1996 Jan 19;39(2):609-13 [8558534] Adv Immunol. 1996;62:167-215 [8781269] J Neurosci. 1997 Jan 1;17(1):117-24 [8987741] J Neurosci. 1997 Apr 15;17(8):2746-55 [9092596] Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41 [9537820] J Neurobiol. 1998 Apr;35(1):29-36 [9552164] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15792-7 [9861049] J Neurochem. 1999 Jun;72(6):2583-92 [10349870] J Neuroimmunol. 1999 Jan 1;93(1-2):53-71 [10378869] Am J Pathol. 1999 Sep;155(3):995-1004 [10487857] J Immunol. 1999 Oct 1;163(7):3963-8 [10490998] Stroke. 2005 Feb;36(2):182-5 [15637312] Nature. 2005 Feb 17;433(7027):696-8 [15716937] FASEB J. 2005 Jul;19(9):1134-6 [15845609] Brain Res. 2005 Jul 19;1050(1-2):130-7 [15979590] Eur J Pharmacol. 2005 Jul 4;517(1-2):17-27 [15964567] Glia. 2005 Oct;52(1):70-7 [15920732] Toxicol Sci. 2006 Jan;89(1):265-70 [16237196] Brain Res. 2005 Dec 20;1066(1-2):71-7 [16360658] Nat Med. 2006 Feb;12(2):225-9 [16432513] J Neurotrauma. 2006 Dec;23(12):1895-903 [17184197] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1742-2094-6-5 ER - TY - JOUR T1 - Zonisamide for essential tremor: an evaluator-blinded study. AN - 742774566; pmid-19117357 AB - In this evaluator-blinded open-treatment trial, subjects with moderate/severe upper limb essential tremor were titrated to 300 mg/day zonisamide, or adjusted to a lesser dose if symptoms warranted, as monotherapy or as adjunct to stable antitremor medication, followed by a 12-week extension phase. The primary efficacy outcome variables were blinded rater videotaped/drawing tremor score changes at the Treatment and Extension visits compared to Baseline, based on Fahn-Tolosa-Marin and Postural Tremor Scales. Subjects also rated Functional Disabilities. Primary outcomes showed reduced tremor scores at the Treatment (P < 0.00001, n = 25) and Extension (n = 16) visits, at mean doses of 252 and 225 mg/day, respectively. Subject ratings indicated 200 mg/day was superior to 100 mg/day, whereas 300 mg/day produced no additional benefit, but instead was associated with more adverse symptoms, most commonly somnolence, poor energy, imbalance, and altered taste. Future double-blind placebo-controlled trials are warranted. (c) 2008 Movement Disorders Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Handforth, Adrian AU - Martin, Fredricka C AU - Kang, Gail A AU - Vanek, Zeba AD - Department of Neurology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA. charles.handforth@med.va.gov Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 SP - 437 EP - 440 VL - 24 IS - 3 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Severity of Illness Index KW - Drug Administration Schedule KW - Single-Blind Method KW - Humans KW - Aged KW - Upper Extremity -- physiopathology KW - Female KW - Male KW - Essential Tremor -- drug therapy KW - Anticonvulsants -- therapeutic use KW - Isoxazoles -- therapeutic use KW - Essential Tremor -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742774566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Zonisamide+for+essential+tremor%3A+an+evaluator-blinded+study.&rft.au=Handforth%2C+Adrian%3BMartin%2C+Fredricka+C%3BKang%2C+Gail+A%3BVanek%2C+Zeba&rft.aulast=Handforth&rft.aufirst=Adrian&rft.date=2009-02-15&rft.volume=24&rft.issue=3&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Defining and measuring dysphagia following stroke. AN - 85390170; pmid-18930911 AB - To continue the development of a quantified, standard method to differentiate individuals with stroke and dysphagia from individuals without dysphagia.Videofluoroscopic swallowing studies (VFSS) were completed on a group of participants with acute stroke (n = 42) and healthy age-matched individuals (n = 25). Calibrated liquid volumes of 3, 5, 10, and 20 ml were administered during the VFSS. Six measures in 3 domains of bolus flow (timing, direction, and clearance) were measured. Values of these measures obtained from the control group were used to classify dysphagia within the participants.The use of a single measure or single liquid volumes to classify dysphagia did not distinguish between healthy adults and individuals following stroke with and without dysphagia. Abnormality on more than 1 measure across multiple volumes appears to be a more robust method in defining dysphagia for liquids.Our findings indicate that the definition of dysphagia is critical in determining whether persons are classified with disordered swallowing. The definition is dependent on materials and measures evaluated. Each measure provides independent aspects to the evaluation. Determining the level of importance of each depends on the purpose of the evaluation. JF - American journal of speech-language pathology / American Speech-Language-Hearing Association AU - Daniels, Stephanie K AU - Schroeder, Mae Fern AU - DeGeorge, Pamela C AU - Corey, David M AU - Foundas, Anne L AU - Rosenbek, John C AD - Michael E. DeBakey VA Medical Center, Houston, TX, USA. stephanie.daniels@va.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 74 EP - 81 VL - 18 IS - 1 SN - 1058-0360, 1058-0360 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - *Deglutition Disorders: diagnosis KW - Deglutition Disorders: etiology KW - *Deglutition Disorders: physiopathology KW - Female KW - Fluoroscopy KW - Humans KW - Male KW - Middle Aged KW - Reproducibility of Results KW - Stroke: complications KW - *Stroke: physiopathology KW - Video Recording UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85390170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+speech-language+pathology+%2F+American+Speech-Language-Hearing+Association&rft.atitle=Defining+and+measuring+dysphagia+following+stroke.&rft.au=Daniels%2C+Stephanie+K%3BSchroeder%2C+Mae+Fern%3BDeGeorge%2C+Pamela+C%3BCorey%2C+David+M%3BFoundas%2C+Anne+L%3BRosenbek%2C+John+C&rft.aulast=Daniels&rft.aufirst=Stephanie&rft.date=2009-02-01&rft.volume=18&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=American+journal+of+speech-language+pathology+%2F+American+Speech-Language-Hearing+Association&rft.issn=10580360&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Family problems among recently returned military veterans referred for a mental health evaluation. AN - 67000229; 19210950 AB - Existing evidence suggests that military veterans with mental health disorders have poorer family functioning, although little research has focused on this topic. To test whether psychiatric symptoms are associated with family reintegration problems in recently returned military veterans. Cross-sectional survey of a clinical population. Respondents who were referred to behavioral health evaluation from April 2006 through August 2007 were considered for the survey. Philadelphia Veterans Affairs Medical Center, Pa. 199 military veterans who served in Iraq or Afghanistan after 2001 and were referred for behavioral health evaluation from primary care (mean age = 32.7 years, SD = 9.1). Measures included the Mini-International Neuropsychiatric Interview for psychiatric diagnoses, the 9-item Patient Health Questionnaire for depression diagnosis and severity, and screening measures of alcohol abuse and illicit substance use. A measure of military family readjustment problems and a screening measure of domestic abuse were developed for this study. Three fourths of the married/cohabiting veterans reported some type of family problem in the past week, such as feeling like a guest in their household (40.7%), reporting their children acting afraid or not being warm toward them (25.0%), or being unsure about their family role (37.2%). Among veterans with current or recently separated partners, 53.7% reported conflicts involving "shouting, pushing, or shoving," and 27.6% reported that this partner was "afraid of them." Depression and posttraumatic stress disorder symptoms were both associated with higher rates of family reintegration problems. Mental health problems may complicate veterans' readjustment and reintegration into family life. The findings suggest an opportunity to improve the treatment of psychiatric disorders by addressing family problems. Copyright 2009 Physicians Postgraduate Press, Inc. JF - The Journal of clinical psychiatry AU - Sayers, Steven L AU - Farrow, Victoria A AU - Ross, Jennifer AU - Oslin, David W AD - VISN 4 MIRECC 116, Philadelphia VA Medical Center, Philadelphia, PA 19104, USA. Steven.sayers@va.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 163 EP - 170 VL - 70 IS - 2 KW - Index Medicus KW - Alcoholism -- rehabilitation KW - Young Adult KW - Humans KW - Depressive Disorder, Major -- rehabilitation KW - Psychometrics KW - Alcoholism -- psychology KW - Alcoholism -- epidemiology KW - Adaptation, Psychological KW - Adult KW - Anxiety Disorders -- epidemiology KW - Male KW - Spouse Abuse -- psychology KW - Arousal KW - Anxiety Disorders -- psychology KW - Philadelphia KW - Anxiety Disorders -- rehabilitation KW - Depressive Disorder, Major -- epidemiology KW - Parent-Child Relations KW - Spouse Abuse -- statistics & numerical data KW - Cross-Sectional Studies KW - Mass Screening KW - Bipolar Disorder -- epidemiology KW - Bipolar Disorder -- rehabilitation KW - Personality Assessment -- statistics & numerical data KW - Depressive Disorder, Major -- psychology KW - Role KW - Bipolar Disorder -- psychology KW - Middle Aged KW - Female KW - Referral and Consultation -- statistics & numerical data KW - Depressive Disorder -- epidemiology KW - Afghan Campaign 2001- KW - Combat Disorders -- psychology KW - Veterans -- statistics & numerical data KW - Depressive Disorder -- psychology KW - Iraq War, 2003-2011 KW - Veterans -- psychology KW - Combat Disorders -- rehabilitation KW - Combat Disorders -- epidemiology KW - Family Conflict -- psychology KW - Depressive Disorder -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67000229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Family+problems+among+recently+returned+military+veterans+referred+for+a+mental+health+evaluation.&rft.au=Sayers%2C+Steven+L%3BFarrow%2C+Victoria+A%3BRoss%2C+Jennifer%3BOslin%2C+David+W&rft.aulast=Sayers&rft.aufirst=Steven&rft.date=2009-02-01&rft.volume=70&rft.issue=2&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=1555-2101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-23 N1 - Date created - 2009-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of hypotensive challenge on systemic hemodynamics and cerebral blood flow in persons with tetraplegia. AN - 66936684; 18850311 AB - Individuals with tetraplegia have impaired central control of sympathetic vascular modulation and blood pressure (BP); how this impairment affects cerebral blood flow (CBF) is unclear. To determine if persons with tetraplegia maintain CBF similarly to able-bodied controls after a hypotensive challenge. Seven individuals with chronic tetraplegia and seven age-matched, non-SCI control subjects underwent a hypotensive challenge consisting of angiotensin-converting enzyme (ACE) inhibition (1.25 mg enalaprilat) and 45 degrees head-up tilt (HUT). Heart rate (HR), low frequency systolic BP variability (LFsbp), brachial mean arterial pressure (MAP) and middle cerebral artery CBF were measured before and after the challenge. Group differences for the baseline (BL) to post-challenge response were determined by repeated measures ANOVA. HR did not differ between the groups in response to the hypotensive challenge. LFsbp response was significantly reduced in the tetra compared to the control group (-38 +/- 51 vs. 72 +/- 93%, respectively). MAP did not differ between the groups at BL but was significantly lower in the tetra compared to the control group post-challenge (55 +/- 13 vs. 71 +/- 9 mmHg, respectively); the percent change in MAP was significantly greater in the tetra than in the control group (-29 +/- 14.1 vs. -13 +/- 9%, respectively). However, CBF did not differ between the groups at baseline or post-challenge; the percent change in CBF post-challenge was not different between the tetra and control groups (-29 +/- 13.2 vs. -23 +/- 10.3%, respectively). Despite impaired sympathetic vasomotor and BP control, CBF in persons with tetraplegia was comparable to that of control subjects during a hypotensive challenge. JF - Clinical autonomic research : official journal of the Clinical Autonomic Research Society AU - Handrakis, John P AU - DeMeersman, Ronald E AU - Rosado-Rivera, Dwindally AU - LaFountaine, Michael F AU - Spungen, Ann M AU - Bauman, William A AU - Wecht, Jill M AD - Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA. john.handrakis@va.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 39 EP - 45 VL - 19 IS - 1 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Enalaprilat KW - GV0O7ES0R3 KW - Index Medicus KW - Hypotension -- chemically induced KW - Humans KW - Adult KW - Tilt-Table Test KW - Middle Aged KW - Enalaprilat -- pharmacology KW - Male KW - Female KW - Angiotensin-Converting Enzyme Inhibitors -- pharmacology KW - Hemodynamics -- drug effects KW - Hemodynamics -- physiology KW - Quadriplegia -- physiopathology KW - Cerebrovascular Circulation -- physiology KW - Cerebrovascular Circulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66936684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=National+Veterans+Health+Administration+hospitalizations+for+syncope+compared+to+acute+myocardial+infarction%2C+fracture%2C+or+pneumonia+in+community-dwelling+elders%3A+outpatient+medication+and+comorbidity+profiles.&rft.au=French%2C+Dustin+D%3BCampbell%2C+Robert%3BSpehar%2C+Andrea%3BRubenstein%2C+Laurence+Z%3BAccomando%2C+John%3BCunningham%2C+Francesca&rft.aulast=French&rft.aufirst=Dustin&rft.date=2006-06-01&rft.volume=46&rft.issue=6&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-30 N1 - Date created - 2009-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10286-008-0496-6 ER - TY - JOUR T1 - Design of combination angiotensin receptor blocker and angiotensin-converting enzyme inhibitor for treatment of diabetic nephropathy (VA NEPHRON-D). AN - 66926303; 19118120 AB - Both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) can slow the progression of diabetic nephropathy. Even with ACEI or ARB treatment, the proportion of patients who progress to end-stage renal disease (ESRD) remains high. Interventions that achieve more complete blockade of the renin-angiotensin system, such as combination ACEI and ARB, might be beneficial. This approach may decrease progression of nondiabetic kidney disease. In diabetic nephropathy, combination therapy decreases proteinuria, but its effect in slowing progression is unknown. In addition, the potential for hyperkalemia may limit the utility of combined therapy in this population. VA NEPHRON-D is a randomized, double-blind, multicenter clinical trial to assess the effect of combination losartan and lisinopril, compared with losartan alone, on the progression of kidney disease in 1850 patients with diabetes and overt proteinuria. The primary endpoints are time to (1) reduction in estimated GFR (eGFR) of > 50% (if baseline or = 60 ml/min/1.73 m(2)); (3) progression to ESRD (need for dialysis, renal transplant, or eGFR 6 mEq/L, requiring admission, emergency room visit, or dialysis), all-cause mortality, and other serious adverse events. This paper discusses the design and key methodological issues that arose during the planning of the study. JF - Clinical journal of the American Society of Nephrology : CJASN AU - Fried, Linda F AU - Duckworth, William AU - Zhang, Jane Hongyuan AU - O'Connor, Theresa AU - Brophy, Mary AU - Emanuele, Nicholas AU - Huang, Grant D AU - McCullough, Peter A AU - Palevsky, Paul M AU - Seliger, Stephen AU - Warren, Stuart R AU - Peduzzi, Peter AU - VA NEPHRON-D Investigators AD - Veterans Affairs Pittsburgh Healthcare System and Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylviania 15240, USA. Linda.Fried@va.gov ; VA NEPHRON-D Investigators Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 361 EP - 368 VL - 4 IS - 2 KW - Angiotensin II Type 1 Receptor Blockers KW - 0 KW - Angiotensin-Converting Enzyme Inhibitors KW - Lisinopril KW - E7199S1YWR KW - Losartan KW - JMS50MPO89 KW - Index Medicus KW - United States KW - Double-Blind Method KW - Kidney Transplantation KW - Glomerular Filtration Rate -- drug effects KW - Humans KW - Disease Progression KW - Hyperkalemia -- chemically induced KW - Renal Dialysis KW - Research Design KW - Drug Therapy, Combination KW - Prospective Studies KW - United States Department of Veterans Affairs KW - Treatment Outcome KW - Time Factors KW - Lisinopril -- adverse effects KW - Kidney Failure, Chronic -- prevention & control KW - Proteinuria -- mortality KW - Diabetic Nephropathies -- physiopathology KW - Losartan -- adverse effects KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Lisinopril -- therapeutic use KW - Kidney Failure, Chronic -- etiology KW - Diabetes Mellitus, Type 2 -- physiopathology KW - Diabetes Mellitus, Type 2 -- mortality KW - Diabetic Nephropathies -- drug therapy KW - Proteinuria -- etiology KW - Angiotensin II Type 1 Receptor Blockers -- adverse effects KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Proteinuria -- physiopathology KW - Angiotensin-Converting Enzyme Inhibitors -- therapeutic use KW - Diabetic Nephropathies -- mortality KW - Proteinuria -- drug therapy KW - Diabetes Mellitus, Type 2 -- complications KW - Kidney Failure, Chronic -- physiopathology KW - Diabetic Nephropathies -- etiology KW - Kidney Failure, Chronic -- mortality KW - Angiotensin II Type 1 Receptor Blockers -- therapeutic use KW - Losartan -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66926303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+journal+of+the+American+Society+of+Nephrology+%3A+CJASN&rft.atitle=Design+of+combination+angiotensin+receptor+blocker+and+angiotensin-converting+enzyme+inhibitor+for+treatment+of+diabetic+nephropathy+%28VA+NEPHRON-D%29.&rft.au=Fried%2C+Linda+F%3BDuckworth%2C+William%3BZhang%2C+Jane+Hongyuan%3BO%27Connor%2C+Theresa%3BBrophy%2C+Mary%3BEmanuele%2C+Nicholas%3BHuang%2C+Grant+D%3BMcCullough%2C+Peter+A%3BPalevsky%2C+Paul+M%3BSeliger%2C+Stephen%3BWarren%2C+Stuart+R%3BPeduzzi%2C+Peter%3BVA+NEPHRON-D+Investigators&rft.aulast=Fried&rft.aufirst=Linda&rft.date=2009-02-01&rft.volume=4&rft.issue=2&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Clinical+journal+of+the+American+Society+of+Nephrology+%3A+CJASN&rft.issn=1555-905X&rft_id=info:doi/10.2215%2FCJN.03350708 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-11 N1 - Date created - 2009-02-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biometrics. 1986 Sep;42(3):507-19 [3567285] N Engl J Med. 2004 Aug 5;351(6):585-92 [15295051] N Engl J Med. 1993 Nov 11;329(20):1456-62 [8413456] N Engl J Med. 1996 Apr 11;334(15):939-45 [8596594] Lancet. 1997 Jun 28;349(9069):1857-63 [9217756] Lancet. 1999 Jul 31;354(9176):359-64 [10437863] J Am Soc Nephrol. 2004 Dec;15(12):3175-83 [15579521] Lancet. 2005 Dec 10;366(9502):2026-33 [16338452] Am J Nephrol. 2006;26(6):629, 632; author reply 629-32 [17236263] Clin J Am Soc Nephrol. 2006 Jul;1(4):874-84 [17699300] N Engl J Med. 2008 Apr 10;358(15):1547-59 [18378520] Lancet. 2008 May 10;371(9624):1575-6 [18468534] Lancet. 2008 Aug 16;372(9638):547-53 [18707986] Lancet. 2000 May 6;355(9215):1582-7 [10821361] Kidney Int. 2001 Jun;59(6):2282-9 [11380832] N Engl J Med. 2001 Sep 20;345(12):851-60 [11565517] N Engl J Med. 2001 Sep 20;345(12):861-9 [11565518] N Engl J Med. 2001 Sep 20;345(12):915-9 [11565527] N Engl J Med. 2001 Dec 6;345(23):1667-75 [11759645] Diabetes Care. 2002 Jan;25(1):95-100 [11772908] Acta Diabetol. 2001 Dec;38(4):157-61 [11855793] Nephrol Dial Transplant. 2002 Jun;17(6):1019-24 [12032191] Lancet. 2003 Jan 11;361(9352):117-24 [12531578] Kidney Int. 2003 May;63(5):1874-80 [12675866] Diabetes Care. 2003 Aug;26(8):2268-74 [12882847] Lancet. 2003 Sep 6;362(9386):767-71 [13678869] Kidney Int Suppl. 2003 Nov;(87):S24-31 [14531770] N Engl J Med. 2003 Nov 13;349(20):1893-906 [14610160] Circulation. 2004 Jun 1;109(21):2492-9 [15173039] Int J Clin Pract. 2004 May;58(5):432-5 [15206496] Control Clin Trials. 1991 Oct;12(5):566-86 [1664792] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2215/CJN.03350708 ER - TY - JOUR T1 - Occupational history quality in patients with newly documented, clinician-diagnosed chronic bronchitis. AN - 66897292; 18719054 AB - Approximately 15% of cases of COPD, including chronic bronchitis, is attributable to occupational exposures. An occupational history is essential to identify exposures responsible for work-related chronic bronchitis. We conducted a structured retrospective analysis of the medical records of veterans, 18 to 70 years of age, newly diagnosed with chronic bronchitis in order to achieve the following: (1) to assess the quality of documented occupational histories; and (2) to characterize the management of patients with a history of exposure to a potentially hazardous respiratory substance. We also analyzed occupational exposure data reported by patients on a structured questionnaire. Sixty patients were included in the final analysis. A total of 6,150 notes were reviewed. Occupational status was documented in the records of 54 patients (90%). A description of occupational duties was recorded in 32 records (53%), and work exposure data in 26 records (43%). Clinicians concluded that occupational exposures potentially contributed to chronic bronchitis in three patients (5%). A recommendation for exposure avoidance was documented for six patients (10%). On the questionnaire, most patients reported a history of occupational exposure to respirable substances and symptoms of cough and/or shortness of breath. Details about job duties and occupational respiratory exposures were documented in the records of approximately half of patients with newly diagnosed chronic bronchitis. Patient self-reports of occupational exposures and respiratory symptoms were common. A determination that occupational exposures contributed to chronic bronchitis was rare. Few patients were counseled to take measures to avoid occupational exposures. Work-related chronic bronchitis may be incompletely assessed and undermanaged by clinicians. JF - Chest AU - Kuschner, Ware G AU - Hegde, Shainy AU - Agrawal, Madhuri AD - Pulmonary Section, US Department of Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. ware.kuschnermd@va.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 378 EP - 383 VL - 135 IS - 2 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Severity of Illness Index KW - Sensitivity and Specificity KW - Respiratory Function Tests KW - Young Adult KW - International Classification of Diseases KW - Humans KW - Retrospective Studies KW - Aged KW - Workplace KW - Employment KW - Age Distribution KW - Inhalation Exposure KW - Adult KW - Surveys and Questionnaires KW - Incidence KW - Follow-Up Studies KW - Middle Aged KW - Adolescent KW - Sex Distribution KW - Male KW - Occupational Diseases -- diagnosis KW - Medical History Taking -- methods KW - Bronchitis, Chronic -- epidemiology KW - Bronchitis, Chronic -- etiology KW - Bronchitis, Chronic -- diagnosis KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66897292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Occupational+history+quality+in+patients+with+newly+documented%2C+clinician-diagnosed+chronic+bronchitis.&rft.au=Kuschner%2C+Ware+G%3BHegde%2C+Shainy%3BAgrawal%2C+Madhuri&rft.aulast=Kuschner&rft.aufirst=Ware&rft.date=2009-02-01&rft.volume=135&rft.issue=2&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=1931-3543&rft_id=info:doi/10.1378%2Fchest.08-1559 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-09 N1 - Date created - 2009-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1378/chest.08-1559 ER - TY - JOUR T1 - Gastrin, Helicobacter pylori, and colorectal adenomas. AN - 66881013; 18929688 AB - Hypergastrinemia and Helicobacter pylori (Hp) infection have been associated with an increased risk for colorectal neoplasia in some studies. However, data from large prospective studies of both associations are lacking. The aim of this study was to evaluate whether serum gastrin levels and/or infection with Hp are associated with the subsequent development of colorectal adenomas. Subjects (all with a history of adenoma formation) were drawn from 2 previously completed adenoma chemoprevention trials. Participants underwent clearing colonoscopy at baseline with follow-up colonoscopy 1 and 4 years after enrollment. We used commercially available assays on fasting blood specimens to measure serum gastrin levels and Hp serologies 1 year after randomization. Risk ratios for adenoma and advanced adenoma development during the subsequent 3 years were computed by generalized linear regression. Of the 1794 subjects randomized in the 2 trials, 685 had available serum and were included in the analyses. Gastrin levels were significantly higher in the 239 subjects with Hp titers indicating infection (mean, 88.3 pg/mL) than in those not infected (mean, 73.9 pg/mL; P < .001). In fully adjusted models, gastrin levels were not associated with incident adenoma development (risk ratio [RR], 1.10; 95% confidence interval [CI], 0.78-1.54) or advanced adenoma formation (RR, 0.82; 95% CI, 0.33-2.03). A positive Hp serology was associated with a decreased risk for adenoma formation (RR, 0.76; 95% CI, 0.60-0.96). Neither hypergastrinemia nor serologic evidence of Hp infection were associated with an increased risk for recurrent adenoma development. These results do not support the notion that gastrin promotes colorectal carcinogenesis, at least at the stage of adenoma development. JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association AU - Robertson, Douglas J AU - Sandler, Robert S AU - Ahnen, Dennis J AU - Greenberg, E Robert AU - Mott, Leila A AU - Cole, Bernard F AU - Baron, John A AD - VA Medical Center, White River Junction, Vermont 05009, USA. douglas.robertson@va.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 163 EP - 167 VL - 7 IS - 2 KW - Antibodies, Bacterial KW - 0 KW - Gastrins KW - Index Medicus KW - Odds Ratio KW - Humans KW - Middle Aged KW - Male KW - Female KW - Risk Assessment KW - Helicobacter Infections -- complications KW - Gastrins -- blood KW - Antibodies, Bacterial -- blood KW - Adenoma -- epidemiology KW - Colorectal Neoplasms -- etiology KW - Adenoma -- etiology KW - Colorectal Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66881013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+gastroenterology+and+hepatology+%3A+the+official+clinical+practice+journal+of+the+American+Gastroenterological+Association&rft.atitle=Gastrin%2C+Helicobacter+pylori%2C+and+colorectal+adenomas.&rft.au=Robertson%2C+Douglas+J%3BSandler%2C+Robert+S%3BAhnen%2C+Dennis+J%3BGreenberg%2C+E+Robert%3BMott%2C+Leila+A%3BCole%2C+Bernard+F%3BBaron%2C+John+A&rft.aulast=Robertson&rft.aufirst=Douglas&rft.date=2009-02-01&rft.volume=7&rft.issue=2&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Clinical+gastroenterology+and+hepatology+%3A+the+official+clinical+practice+journal+of+the+American+Gastroenterological+Association&rft.issn=1542-7714&rft_id=info:doi/10.1016%2Fj.cgh.2008.09.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-06 N1 - Date created - 2009-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cgh.2008.09.006 ER - TY - JOUR T1 - The top 10 things nephrologists wish every primary care physician knew. AN - 66879353; 19181652 AB - Renal disease is commonly encountered by primary care physicians during their day-to-day visits with patients. Common renal disorders include hypertension, proteinuria, kidney stones, and chronic kidney disease. Despite their prevalence, many physicians may be unfamiliar with the diagnosis and initial treatment of these common renal disorders. Early recognition and intervention are important in slowing the progression of chronic kidney disease and preventing its complications. The evidence-based pearls in this article will help primary care physicians avoid common pitfalls in the recognition and treatment of such disorders and guide their decision to refer their patients to a specialist. JF - Mayo Clinic proceedings AU - Paige, Neil M AU - Nagami, Glenn T AD - Department of Medicine, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, CA 90073, USA. neil.paige@va.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 180 EP - 186 VL - 84 IS - 2 KW - Angiotensin II Type 1 Receptor Blockers KW - 0 KW - Angiotensin-Converting Enzyme Inhibitors KW - Antacids KW - Cathartics KW - Immunosuppressive Agents KW - Phosphates KW - Recombinant Proteins KW - Erythropoietin KW - 11096-26-7 KW - Cyclosporine KW - 83HN0GTJ6D KW - Creatinine KW - AYI8EX34EU KW - Aluminum KW - CPD4NFA903 KW - Magnesium KW - I38ZP9992A KW - sodium phosphate KW - SE337SVY37 KW - Tacrolimus KW - WM0HAQ4WNM KW - Abridged Index Medicus KW - Index Medicus KW - Drug Interactions KW - Evidence-Based Medicine KW - Antacids -- contraindications KW - Drug-Related Side Effects and Adverse Reactions KW - Humans KW - Erythropoietin -- therapeutic use KW - Disease Progression KW - Phosphates -- adverse effects KW - Blood Urea Nitrogen KW - Creatinine -- blood KW - Cyclosporine -- adverse effects KW - Hypertension -- diagnosis KW - Angiotensin-Converting Enzyme Inhibitors -- therapeutic use KW - Proteinuria -- complications KW - Hypertension -- etiology KW - Anemia -- complications KW - Nephrolithiasis -- complications KW - Aluminum -- analysis KW - Tacrolimus -- adverse effects KW - Cathartics -- adverse effects KW - Magnesium -- contraindications KW - Creatinine -- urine KW - Blood Pressure KW - Nephrology KW - Referral and Consultation KW - Aluminum -- contraindications KW - Cardiovascular Diseases -- prevention & control KW - Antacids -- chemistry KW - Glomerular Filtration Rate KW - Magnesium -- analysis KW - Anemia -- drug therapy KW - Angiotensin II Type 1 Receptor Blockers -- therapeutic use KW - Chronic Disease KW - Urinalysis KW - Immunosuppressive Agents -- adverse effects KW - Kidney Diseases -- therapy KW - Primary Health Care KW - Kidney Diseases -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66879353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mayo+Clinic+proceedings&rft.atitle=The+top+10+things+nephrologists+wish+every+primary+care+physician+knew.&rft.au=Paige%2C+Neil+M%3BNagami%2C+Glenn+T&rft.aulast=Paige&rft.aufirst=Neil&rft.date=2009-02-01&rft.volume=84&rft.issue=2&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Mayo+Clinic+proceedings&rft.issn=1942-5546&rft_id=info:doi/10.1016%2FS0025-6196%2811%2960826-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am Heart J. 1984 Nov;108(5):1347-52 [6496291] Cleve Clin J Med. 2008 Mar;75(3):173-6 [18383926] Arch Intern Med. 1987 May;147(5):943-4 [3555378] Am J Med Sci. 1989 Jan;297(1):9-11 [2913801] Clin Nephrol. 1989 Jan;31(1):40-4 [2914409] Am J Kidney Dis. 1989 Feb;13(2):127-30 [2629709] J Urol. 1989 Mar;141(3 Pt 2):760-3 [2645436] Arch Intern Med. 1990 Oct;150(10):2037-9 [2171446] Arch Intern Med. 2000 Mar 13;160(5):685-93 [10724055] Neurotoxicology. 2000 Oct;21(5):813-28 [11130287] J Endourol. 2001 Mar;15(2):181-6 [11325090] Nephrol Dial Transplant. 2002;17 Suppl 2:13-6 [11904352] J Clin Gastroenterol. 2002 Apr;34(4):457-8 [11907363] Hypertens Res. 2004 Mar;27(3):193-202 [15080378] Acta Med Scand. 1981;209(6):451-5 [7257863] N Engl J Med. 1983 Dec 22;309(25):1543-6 [6656849] Am J Kidney Dis. 1991 Jun;17(6):708-11 [2042654] Am J Kidney Dis. 1993 Jul;22(1):5-10 [8322793] Ther Drug Monit. 1993 Dec;15(6):593-7 [8122300] Am J Kidney Dis. 1997 Jan;29(1):103-5 [9002537] Dis Colon Rectum. 1997 Apr;40(4):497-9 [9106703] Am J Kidney Dis. 1999 Jul;34(1):125-34 [10401026] Kidney Int. 2005 Mar;67(3):799-812 [15698420] Kidney Int. 2005 Jun;67(6):2089-100 [15882252] J Am Soc Nephrol. 2005 Nov;16(11):3389-96 [16192415] J Clin Hypertens (Greenwich). 2006 Mar;8(3):181-6 [16522995] Gastrointest Endosc. 2006 Jun;63(7):894-909 [16733101] Ann Intern Med. 2006 Jul 18;145(2):117-24 [16847294] N Engl J Med. 2006 Nov 16;355(20):2071-84 [17108342] N Engl J Med. 2006 Nov 16;355(20):2085-98 [17108343] Lancet. 2007 Feb 3;369(9559):381-8 [17276778] Am J Kidney Dis. 2007 Sep;50(3):471-530 [17720528] Ann Intern Med. 2008 Jan 1;148(1):30-48 [17984482] South Med J. 2008 Feb;101(2):166-73 [18364619] Am J Kidney Dis. 1987 Jan;9(1):23-6 [3812479] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S0025-6196(11)60826-4 ER - TY - JOUR T1 - A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence. AN - 66865830; 18945226 AB - Current medications for alcohol dependence (AD) show only modest efficacy. None target brain noradrenergic pathways. Theory and preclinical evidence suggest that noradrenergic circuits may be involved in alcohol reinforcement and relapse. We therefore tested the alpha-1 adrenergic receptor antagonist, prazosin, as a pharmacotherapy for AD. We randomized 24 participants with AD but without posttraumatic stress disorder to receive either prazosin or placebo in a 6-week, double-blind pilot study. Medication was titrated to a target dose of 4 mg QAM, 4 mg QPM, and 8 mg QHS by the end of week 2. Participants received 5 medical management treatment sessions. Participants were reminded 3 times each day via a text pager to take medications and to call a telephone monitoring system once daily to provide self-reports of alcohol consumption and craving, the primary outcome measures. Results were analyzed using mixed linear regression adjusted for drinking days per week at baseline and week number. Twenty of the 24 (83%) subjects completed. Among the completers, the prazosin group reported fewer drinking days per week than the placebo group during the final 3 weeks of the study. Since only 1 woman was randomized to placebo and only three women completed the trial, the following results focus on the 17 male completers. The prazosin group reported fewer drinking days per week and fewer drinks per week during the final 3 weeks of the study; average total number of drinking days for the placebo group 5.7 (SEM 1.9) versus 0.9 (SEM 0.5) for the prazosin group, and average total number of drinks 20.8 (SEM 6.5) for the placebo group versus 2.6 (SEM 1.3) for the prazosin group. Rates of adverse events were equivalent across conditions. Prazosin holds promise as a pharmacologic treatment for AD and deserves further evaluation in a larger controlled trial. JF - Alcoholism, clinical and experimental research AU - Simpson, Tracy L AU - Saxon, Andrew J AU - Meredith, Charles W AU - Malte, Carol A AU - McBride, Brittney AU - Ferguson, Laura C AU - Gross, Christopher A AU - Hart, Kim L AU - Raskind, Murray AD - Center of Excellence in Substance Abuse Treatment and Education, University of Washington, Seattle, WA 98108, USA. Tracy.Simpson@va.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 255 EP - 263 VL - 33 IS - 2 KW - Adrenergic alpha-Antagonists KW - 0 KW - Prazosin KW - XM03YJ541D KW - Index Medicus KW - Young Adult KW - Psychiatric Status Rating Scales KW - Double-Blind Method KW - Patient Compliance KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Pilot Projects KW - Middle Aged KW - Affect KW - Adolescent KW - Male KW - Female KW - Prazosin -- adverse effects KW - Adrenergic alpha-Antagonists -- therapeutic use KW - Prazosin -- therapeutic use KW - Alcoholism -- psychology KW - Adrenergic alpha-Antagonists -- adverse effects KW - Alcoholism -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66865830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=A+pilot+trial+of+the+alpha-1+adrenergic+antagonist%2C+prazosin%2C+for+alcohol+dependence.&rft.au=Yohe%2C+Herbert+C%3BO%27Hara%2C+Kimberley+A%3BHunt%2C+Jane+A%3BKitzmiller%2C+Tamar+J%3BWood%2C+Sheryl+G%3BBement%2C+Jenna+L%3BBement%2C+William+J%3BSzakacs%2C+Juliana+G%3BWrighton%2C+Steven+A%3BJacobs%2C+Judith+M%3BKostrubsky%2C+Vsevolod%3BSinclair%2C+Peter+R%3BSinclair%2C+Jacqueline+F&rft.aulast=Yohe&rft.aufirst=Herbert&rft.date=2006-06-01&rft.volume=290&rft.issue=6&rft.spage=G1269&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.issn=01931857&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-10 N1 - Date created - 2009-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1530-0277.2008.00807.x ER - TY - JOUR T1 - Methadone: a new old drug with promises and pitfalls. AN - 66794302; 19126367 AB - Although methadone is not a new medication, its use in pain management has increased rapidly over the past decade. This article reviews the unique pharmacologic properties of methadone, including its long-acting nature, highly variable clearance rate, and its antagonism of the N-methyl-D-aspartate receptor. We discuss potential benefits and risks of methadone over other opioid medications. Preclinical studies suggest methadone may reduce abuse potential, tolerance development, and sensitization of nociceptive pathways. Pharmacologic properties of methadone suggest potential greater risk of dangerous or fatal side effects from overdose, QT interval prolongation, and drug interactions. However, clinical studies have yet to confirm that methadone produces either better clinical outcomes or higher rates of adverse events than other opioid analgesics. Clinicians who understand the special properties of methadone and follow recommended precautionary prescribing and monitoring practices can safely and effectively use methadone for pain treatment. JF - Current pain and headache reports AU - Trafton, Jodie A AU - Ramani, Abhinav AD - Center for Health Care Evaluation, VA Palo Alto and Stanford University School of Medicine, 795 Willow Road (152-MPD), Menlo Park, CA 94025, USA. Jodie.Trafton@va.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 24 EP - 30 VL - 13 IS - 1 KW - Anti-Bacterial Agents KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Opioid-Related Disorders -- metabolism KW - Animals KW - Humans KW - Opioid-Related Disorders -- drug therapy KW - Anti-Bacterial Agents -- pharmacokinetics KW - Drug Interactions -- physiology KW - Methadone -- adverse effects KW - Methadone -- pharmacokinetics KW - Methadone -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66794302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+pain+and+headache+reports&rft.atitle=Methadone%3A+a+new+old+drug+with+promises+and+pitfalls.&rft.au=Trafton%2C+Jodie+A%3BRamani%2C+Abhinav&rft.aulast=Trafton&rft.aufirst=Jodie&rft.date=2009-02-01&rft.volume=13&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Current+pain+and+headache+reports&rft.issn=1534-3081&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-12 N1 - Date created - 2009-01-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assisted Living Pilot Program: Background, Methods, and Facility Characteristics AN - 61447068; 200902619 AB - Objectives: The Department of Veterans Affairs (VA) funded assisted living (AL), adult family home (AFH), and residential care for the first time in the Assisted Living Pilot Program (ALPP). This article describes the background and methods of the ALPP evaluation and the characteristics and experiences of the facilities. Method: Facility data were collected from the contracting/inspection process and a survey of ALPP facilities and those contacted but not participating in ALPP. Results: Data on 131 participating facilities are presented: 41 AFHs, 47 assisted living facilities (ALFs), and 43 residential care facilities (RCFs). The average facility had 33 beds (about one quarter Medicaid beds), for-profit ownership, and private rooms for ALPP residents, and about half had private baths. About two thirds of ALPP AFH providers spoke a primary language other than English. Discussion: Findings indicate that a wide range of community facilities were willing to provide care to residents with heterogeneous needs on VA funding. [Reprinted by permission of Sage Publications Ltd., copyright.] JF - Journal of Aging and Health AU - Guihan, Marylou AU - Thomas, Mark D AU - Mambourg, Floss J AU - Wang, Li AU - Chapko, Michael K AU - Hedrick, Susan C AD - PO Box 5000 (151-H), Hines, IL 60141-5000 marylou.guihan@va.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 172 EP - 189 PB - Sage Publications, Thousand Oaks CA VL - 21 IS - 1 SN - 0898-2643, 0898-2643 KW - assisted living, residential care facilities, long-term care KW - Assistance KW - Adult Care Services KW - Delivery Systems KW - Elderly KW - Long Term Care KW - Residential Institutions KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61447068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aging+and+Health&rft.atitle=Assisted+Living+Pilot+Program%3A+Background%2C+Methods%2C+and+Facility+Characteristics&rft.au=Guihan%2C+Marylou%3BThomas%2C+Mark+D%3BMambourg%2C+Floss+J%3BWang%2C+Li%3BChapko%2C+Michael+K%3BHedrick%2C+Susan+C&rft.aulast=Guihan&rft.aufirst=Marylou&rft.date=2009-02-01&rft.volume=21&rft.issue=1&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aging+and+Health&rft.issn=08982643&rft_id=info:doi/10.1177%2F0898264308328926 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 15 N1 - Last updated - 2016-09-28 N1 - CODEN - JAHEEG N1 - SubjectsTermNotLitGenreText - Residential Institutions; Long Term Care; Adult Care Services; Elderly; Delivery Systems; Assistance DO - http://dx.doi.org/10.1177/0898264308328926 ER - TY - JOUR T1 - Assisted Living Pilot Program: Health Outcomes AN - 61430300; 200902470 AB - Objectives: Assisted living programs demonstrate variation in structure and services. The Department of Veterans Affairs funded this care for the first time in the Assisted Living Pilot Program (ALPP). This article presents resident health outcomes and the relationship between facility characteristics and outcomes. Method: This article presents results on 393 ALPP residents followed for 12 months after admission to 95 facilities. Results: A total of 19.8% residents died, and the average activities of daily living impairment did not change significantly. Half of the residents remained in an ALPP facility, with the average resident spending 315 days in the community during the 12-month follow-up period. This article found a limited number of characteristics of structure and staffing to be significantly associated with outcomes. Discussion: If differences among facility characteristics are not clearly related to differences in outcomes, then choices among type of setting can be based on the match of needs to available services, location, or preferences. [Reprinted by permission of Sage Publications Ltd., copyright.] JF - Journal of Aging and Health AU - Hedrick, Susan C AU - Guihan, Marylou AU - Chapko, Michael K AU - Sullivan, Jean AU - Zhou, Xiao-Hua AU - Manheim, Larry M AU - Forsberg, Christopher W AU - Mambourg, Floss J AD - Health Services Research and Development, VA Puget Sound Health Care System, 1100 Olive Way Suite 1400, Seattle, WA 98101 susan.hedrick@va.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 190 EP - 207 PB - Sage Publications, Thousand Oaks CA VL - 21 IS - 1 SN - 0898-2643, 0898-2643 KW - assisted living, residential care facilities, long-term care, outcomes, longitudinal design KW - Mortality Rates KW - Assistance KW - Quality of Health Care KW - Elderly KW - Long Term Care KW - Residential Institutions KW - Health KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61430300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aging+and+Health&rft.atitle=Assisted+Living+Pilot+Program%3A+Health+Outcomes&rft.au=Hedrick%2C+Susan+C%3BGuihan%2C+Marylou%3BChapko%2C+Michael+K%3BSullivan%2C+Jean%3BZhou%2C+Xiao-Hua%3BManheim%2C+Larry+M%3BForsberg%2C+Christopher+W%3BMambourg%2C+Floss+J&rft.aulast=Hedrick&rft.aufirst=Susan&rft.date=2009-02-01&rft.volume=21&rft.issue=1&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aging+and+Health&rft.issn=08982643&rft_id=info:doi/10.1177%2F0898264308328929 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 19 N1 - Last updated - 2016-09-28 N1 - CODEN - JAHEEG N1 - SubjectsTermNotLitGenreText - Residential Institutions; Long Term Care; Elderly; Assistance; Health; Mortality Rates; Quality of Health Care DO - http://dx.doi.org/10.1177/0898264308328929 ER - TY - JOUR T1 - Computerized Cognitive -Behavioral Therapy in a Stepped Care Model of Treatment AN - 57301037; 200914874 AB - A growing body of literature suggests that computerized cognitive -behavioral therapies (CCBT) are effective in community settings in terms of symptom reduction, favorable client satisfaction, attrition comparable to standard cognitive -behavioral therapy, reduced clinician time, high cost-effectiveness, and ease of integration into community clinics. Clinicians report lack of knowledge about computerized programs as the main reason that they have not used CCBT in their practice. To mitigate this disconnect between empirical evidence and dissemination, this article first reviews empirical studies focusing on the efficacy of CCBT for specific psychological disorders, followed by a review of research on the effectiveness of CCBT in community settings. Next, issues related to dissemination and barriers to CCBT adoption by clinicians are discussed. Finally, the implications of CCBT for research and practice and the possible role of CCBT in a stepped care model of treatment is discussed in terms of cost-effectiveness, standards of care, and implications for public policy. [Copyright Elsevier B.V.] JF - Professional Psychology: Research and Practice AU - Green, Kelly E AU - Iverson, Katherine M AD - VA Boston Healthcare System Kelly.green3@va.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 96 EP - 103 PB - American Psychological Association, Washington DC VL - 40 IS - 1 SN - 0735-7028, 0735-7028 KW - cognitive -behavioral therapies computerized applications treatment effectiveness evaluation stepped care KW - Clinical outcomes KW - Cognitive behaviour therapy KW - Computer assisted counselling KW - Clinical standards KW - Cost effectiveness KW - Implementation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57301037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Psychology%3A+Research+and+Practice&rft.atitle=Computerized+Cognitive+-Behavioral+Therapy+in+a+Stepped+Care+Model+of+Treatment&rft.au=Green%2C+Kelly+E%3BIverson%2C+Katherine+M&rft.aulast=Green&rft.aufirst=Kelly&rft.date=2009-02-01&rft.volume=40&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Professional+Psychology%3A+Research+and+Practice&rft.issn=07357028&rft_id=info:doi/10.1037%2Fa0012847 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Computer assisted counselling; Clinical outcomes; Cognitive behaviour therapy; Cost effectiveness; Clinical standards; Implementation DO - http://dx.doi.org/10.1037/a0012847 ER - TY - JOUR T1 - Race and the validity of self-reported cancer screening behaviors: Development of a conceptual model AN - 57294383; 200905669 AB - Background Many estimates of cancer screening are based on self-reported screening behavior. There is growing concern that self-reported screening measures may be less accurate among members of racial and ethnic minority groups. This would have considerable implications for research on racial and ethnic disparities in cancer screening. Objectives To review the literature on the relationship between race/ethnicity and the accuracy of self-reported cancer screening behavior and develop a conceptual framework that would provide a deeper understanding of factors underlying this relationship. Methods We developed a conceptual framework drawing from diverse literatures including validation studies examining the accuracy of self-reported cancer screening behaviors and articles on survey response bias. Results and conclusions Evidence suggests that racial and ethnic minorities may be less likely to provide accurate reports of their cancer screening behavior and that overreporting may be particularly problematic. Research conducted in other areas suggests that these sources of measurement error may stem from cognitive and motivational processes and that they can be moderated by question wording and data collection characteristics. At this point, however, the quality of the evidence is not strong and more research is needed before definitive conclusions can be drawn. [Copyright Elsevier B.V.] JF - Preventive Medicine AU - Burgess, Diana J AU - Powell, Adam A AU - Griffin, Joan M AU - Partin, Melissa R AD - Center for Chronic Disease Outcomes Research, Minneapolis VA Medical Center, MN, USA diana.burgess@va.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 99 EP - 107 PB - Elsevier Ltd, The Netherlands VL - 48 IS - 2 SN - 0091-7435, 0091-7435 KW - Cancer screening Minority groups Ethnic groups Self-report Disparities Race/ethnicity African Americans Survey methods Validation studies Social cognition KW - Screening KW - Racial differences KW - Accuracy KW - Ethnic minorities KW - Selfreport KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57294383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=Race+and+the+validity+of+self-reported+cancer+screening+behaviors%3A+Development+of+a+conceptual+model&rft.au=Burgess%2C+Diana+J%3BPowell%2C+Adam+A%3BGriffin%2C+Joan+M%3BPartin%2C+Melissa+R&rft.aulast=Burgess&rft.aufirst=Diana&rft.date=2009-02-01&rft.volume=48&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2008.11.014 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Screening; Cancer; Racial differences; Ethnic minorities; Selfreport; Accuracy DO - http://dx.doi.org/10.1016/j.ypmed.2008.11.014 ER - TY - JOUR T1 - Effects of faith/assurance on cortisol levels are enhanced by a spiritual mantram intervention in adults with HIV: A randomized trial AN - 57267528; 200903139 AB - Objectives Previous research among HIV-infected individuals suggests that spiritual well-being is inversely related to psychological distress and rates of disease progression. Use of a mantram, a spiritual word or phrase repeated frequently and silently throughout the day, has been associated with decreased psychological distress and increased spiritual well-being. This study compared the effects of 2 interventions-a spiritually-based mantram intervention versus an attention-matched control group-on faith/assurance and average salivary cortisol levels among HIV-infected individuals. Methods Using a randomized design, HIV-infected adults were assigned to the intervention (n = 36) or control condition (n = 35). Faith scores and saliva (collected at 7 a.m., 11 a.m., 4 p.m., and 9 p.m.) were assessed at preintervention, postintervention, and 5-week follow-up. Path analyses tested competing models that specify both concurrent and sequential relationships between faith and average daily cortisol levels while comparing groups. Results Faith levels increased among mantram participants from pre- to postintervention. Greater faith at preintervention was significantly associated with lower average cortisol at postintervention in the mantram group but not in the controls. The associations between faith at postintervention and cortisol levels at 5-week follow-up were significant among both groups but weaker than the pre- to postintervention association identified in the mantram group. Conclusions These results suggest the presence of lagged or antecedent consequent relationships between faith and cortisol, which may be enhanced by mantram use. Decreased cortisol could potentially benefit immune functioning among HIV-infected individuals. [Copyright Elsevier Inc.] JF - Journal of Psychosomatic Research AU - Bormann, Jill E AU - Aschbacher, Kirstin AU - Wetherell, Julie L AU - Roesch, Scott AU - Redwine, Laura AD - Veterans Affairs San Diego Healthcare System, San Diego, CA, USA jill.bormann@va.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 161 EP - 171 PB - Elsevier Science Inc. VL - 66 IS - 2 SN - 0022-3999, 0022-3999 KW - Complementary therapies Cortisol HIV/AIDS Meditation Mind-body relaxation technique Psychoneuroimmunology Spirituality KW - Spiritual healing KW - Cortisol KW - Salivary cortisol KW - Psychological distress KW - HIV KW - Spiritual wellbeing KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57267528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychosomatic+Research&rft.atitle=Effects+of+faith%2Fassurance+on+cortisol+levels+are+enhanced+by+a+spiritual+mantram+intervention+in+adults+with+HIV%3A+A+randomized+trial&rft.au=Bormann%2C+Jill+E%3BAschbacher%2C+Kirstin%3BWetherell%2C+Julie+L%3BRoesch%2C+Scott%3BRedwine%2C+Laura&rft.aulast=Bormann&rft.aufirst=Jill&rft.date=2009-02-01&rft.volume=66&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychosomatic+Research&rft.issn=00223999&rft_id=info:doi/10.1016%2Fj.jpsychores.2008.09.017 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - CODEN - JPCRAT N1 - SubjectsTermNotLitGenreText - Cortisol; Psychological distress; Spiritual wellbeing; Salivary cortisol; HIV; Spiritual healing DO - http://dx.doi.org/10.1016/j.jpsychores.2008.09.017 ER - TY - JOUR T1 - Carl Thoresen: The Evolving Pioneer AN - 57258527; 200906301 AB - This interview with Carl E. Thoresen highlights the experiences, relationships, and ideas that have influenced this pioneering psychologist throughout the past half century. His scholarly work, professional service, teaching, and mentor-ship have motivated many counseling psychologists to radically expand their areas of inquiry. He was among the first to focus counseling on observable behaviors and to apply psychological science and interventions to physical problems in medical settings. More recently, he has pioneered the study of the interface between spirituality and health. His intellectual vitality, passion for new ideas, and pioneering spirit have earned him the distinction of being included in the Legacies and Traditions series of The Counseling Psychologist. [Reprinted by permission of Sage Publications Inc., copyright.] JF - The Counseling Psychologist AU - Harris, Alex H S AD - Department of Veterans Affairs, Palo Alto Health Care System Alexander.Harris2@va.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 275 EP - 295 PB - Sage Publications, Thousand Oaks CA VL - 37 IS - 2 SN - 0011-0000, 0011-0000 KW - Mind and body KW - Health psychology KW - Counselling psychologists KW - Spirituality KW - Historical biographies KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57258527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Counseling+Psychologist&rft.atitle=Carl+Thoresen%3A+The+Evolving+Pioneer&rft.au=Harris%2C+Alex+H+S&rft.aulast=Harris&rft.aufirst=Alex+H&rft.date=2009-02-01&rft.volume=37&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=The+Counseling+Psychologist&rft.issn=00110000&rft_id=info:doi/10.1177%2F0011000008316673 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Counselling psychologists; Historical biographies; Health psychology; Mind and body; Spirituality DO - http://dx.doi.org/10.1177/0011000008316673 ER - TY - JOUR T1 - Effect of incentives for medication adherence on health care use and costs in methadone patients with HIV AN - 57250450; 200905482 AB - Background The potential benefits of anti-retroviral therapy for HIV is not fully realized because of difficulties in adherence with demanding treatment regimens, especially among injection drug users. Methods HIV-positive methadone patients who were less than 80% adherent with their primary anti-retroviral therapy were randomized to a trial of incentives for on-time adherence. Adherence was rewarded with an escalating scale of vouchers redeemable for goods. Both intervention and control group visited a medication coach twice a month. The cost of the intervention was determined by micro-costing. Other costs were obtained from administrative data and patient report of out-of-system care. Results During the 12-week intervention period, the incremental direct cost of the intervention, including treatment vouchers, was$942. The voucher group incurred$2572 in anti-retroviral drug cost, significantly more than the$1973 incurred by the comparison group (p < .01). Adherence, as measured by on-time openings of an electronically monitored vial, was 78% in the intervention group and 56% in the control group. Conclusions The incremental direct cost of voucher incentives was$292 per month. If the observed increase in adherence from voucher incentives can be sustained in the long-term, the literature suggests that disease progression will be slowed. Further research is needed to evaluate if the improvement can be sustained or achieved at lower cost. Mitigation of treatment resistance and reduction in HIV transmission are additional benefits that favor adoption. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Barnett, Paul G AU - Sorensen, James L AU - Wong, Wynnie AU - Haug, Nancy A AU - Hall, Sharon M AD - Veterans Affairs Health Economics Resource Center, 795 Willow Rd. (152 MPD), VA Palo Alto Health Care System, Menlo Park, CA 94025, USA paul.barnett@va.gov Y1 - 2009/02/01/ PY - 2009 DA - 2009 Feb 01 SP - 115 EP - 121 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 100 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Anti-HIV agents/therapeutic use Health care costs Methadone Patient compliance Opioid-related disorders KW - Health costs KW - Adherence KW - Antiretroviral therapy KW - Incentives KW - HIV KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57250450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Effect+of+incentives+for+medication+adherence+on+health+care+use+and+costs+in+methadone+patients+with+HIV&rft.au=Barnett%2C+Paul+G%3BSorensen%2C+James+L%3BWong%2C+Wynnie%3BHaug%2C+Nancy+A%3BHall%2C+Sharon+M&rft.aulast=Barnett&rft.aufirst=Paul&rft.date=2009-02-01&rft.volume=100&rft.issue=1-2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2008.09.017 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Health costs; Adherence; Incentives; HIV; Antiretroviral therapy DO - http://dx.doi.org/10.1016/j.drugalcdep.2008.09.017 ER - TY - JOUR T1 - Penicillin-Binding Protein 7/8 Contributes to the Survival of Acinetobacter baumannii In Vitro and In Vivo AN - 20540475; 9225110 AB - Acinetobacter baumannii is a bacterial pathogen of increasing medical importance. Little is known about genes important for its survival in vivo. Methods and results. Screening of random transposon mutants of the model pathogen AB307-0294 identified the mutant AB307.27. AB307.27 contained its transposon insertion in pbpG, which encodes the putative low-molecular- mass penicillin-binding protein 7/8 (PBP-7/8). AB307.27 was significantly killed in ascites, but its growth in Luria-Bertani broth was similar to that of its parent, AB307-0294. The survival of AB307.27 was significantly decreased in a rat soft-tissue infection model and a rat pneumonia model, compared with AB307-0294. AB307.27 was significantly killed in 90% human serum in vitro, compared with AB307-0294. Electron microscopy demonstrated more coccobacillary forms of AB307.27, compared with AB307-0294, suggesting a possible modulation in the peptidoglycan, which may affect susceptibility to host defense factors. Conclusions. These findings demonstrate that PBP-7/8 contributes to the pathogenesis of A. baumannii. PBP-7/8 either directly or indirectly contributes to the resistance of AB307-0294 to complement- mediated bactericidal activity. An understanding of how PBP-7/8 contributes to serum resistance will lend insight into the role of this low-molecular- mass PBP whose function is poorly understood. JF - Journal of Infectious Diseases AU - Russo, Thomas A AU - MacDonald, Ulrike AU - Beanan, Janet M AU - Olson, Ruth AU - MacDonald, Ian J AU - Sauberan, Shauna L AU - Luke, Nicole R AU - Schultz, LWayne AU - Umland, Timothy C AD - Veterans Administration Western New York Healthcare System and The Witebsky Center for Microbial Pathogenesis, Center of Excellence in Bioinformatics and Life Sciences, and Departments of Medicine, Microbiology, and Structural Biology, State University of New York-Buffalo, and Hauptman- Woodward Medical Research Institute, Buffalo, New York, trusso@acsu.buffalo.edu Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 513 EP - 521 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 199 IS - 4 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Animal models KW - Medical importance KW - peptidoglycans KW - Survival KW - penicillin-binding protein KW - Pathogens KW - Infection KW - Models KW - Transposons KW - Acinetobacter baumannii KW - Ascites KW - Bactericidal activity KW - Electron microscopy KW - Pneumonia KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20540475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Penicillin-Binding+Protein+7%2F8+Contributes+to+the+Survival+of+Acinetobacter+baumannii+In+Vitro+and+In+Vivo&rft.au=Russo%2C+Thomas+A%3BMacDonald%2C+Ulrike%3BBeanan%2C+Janet+M%3BOlson%2C+Ruth%3BMacDonald%2C+Ian+J%3BSauberan%2C+Shauna+L%3BLuke%2C+Nicole+R%3BSchultz%2C+LWayne%3BUmland%2C+Timothy+C&rft.aulast=Russo&rft.aufirst=Thomas&rft.date=2009-02-01&rft.volume=199&rft.issue=4&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F596317 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Animal models; Survival; peptidoglycans; Medical importance; penicillin-binding protein; Pathogens; Infection; Models; Transposons; Ascites; Bactericidal activity; Pneumonia; Electron microscopy; Acinetobacter baumannii DO - http://dx.doi.org/10.1086/596317 ER - TY - JOUR T1 - Intimate partner violence against African American women: An examination of the socio-cultural context AN - 20336818; 9010845 AB - Intimate partner violence (IPV) is a significant public health concern that affects an alarmingly high percentage of women. There is evidence to suggest that African American women are impacted by IPV at higher rates than are Caucasian women, yet little of the IPV literature addresses the cultural and structural factors that differentially affect African American and Caucasian couples. The present paper reviews the existing literature on IPV towards African American women, including prevalence, theories, risk factors for victimization, victims' psychological sequelae, barriers to service utilization, coping strategies, and interventions for survivors and perpetrators of IPV. Recommendations for counseling, research, and policy are explored. JF - Aggression and Violent Behavior AU - Taft, Casey T AU - Bryant-Davis, Thema AU - Woodward, Halley E AU - Tillman, Shaquita AU - Torres, Sandra E AD - National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, United States, Casey.Taft@va.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 50 EP - 58 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 14 IS - 1 SN - 1359-1789, 1359-1789 KW - Risk Abstracts; Health & Safety Science Abstracts KW - African Americans KW - Intimate partner violence KW - Culture KW - Psychology KW - Intervention KW - Aggressive behavior KW - domestic violence KW - aggressive behavior KW - Public health KW - intervention KW - Reviews KW - Domestic violence KW - Females KW - culture KW - Ethnic groups KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20336818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aggression+and+Violent+Behavior&rft.atitle=Intimate+partner+violence+against+African+American+women%3A+An+examination+of+the+socio-cultural+context&rft.au=Taft%2C+Casey+T%3BBryant-Davis%2C+Thema%3BWoodward%2C+Halley+E%3BTillman%2C+Shaquita%3BTorres%2C+Sandra+E&rft.aulast=Taft&rft.aufirst=Casey&rft.date=2009-02-01&rft.volume=14&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Aggression+and+Violent+Behavior&rft.issn=13591789&rft_id=info:doi/10.1016%2Fj.avb.2008.10.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Culture; Psychology; domestic violence; Aggressive behavior; Intervention; aggressive behavior; Public health; Reviews; intervention; Females; Domestic violence; Ethnic groups; culture DO - http://dx.doi.org/10.1016/j.avb.2008.10.001 ER - TY - JOUR T1 - Treatment of latent stage Alzheimer''s disease with statins? AN - 1014108823; 16481614 AB - Evaluation of: Haag MD, Hofman A, Koudstaal PJ, Stricker BH, Breteler MM: Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study. J. Neurol. Neurosurg. Psychiatry 80(1), 13--17 (2009). Statins are a class of lipid-lowering agents that are widely prescribed for the control of hypercholesterolemia. Experimental data and some observational studies have suggested that the use of statins may suppress processes of Alzheimer''s disease (AD) and reduce the risk of AD. Here, we review the literature with a focus on recent prospective cohort studies of incident AD and clinical trials in patients with AD. We conclude that emerging data from clinical trials do not support statins as a treatment in patients with dementia from AD. Results from cohort studies are mixed, but one interpretation is that there may be a critical window of opportunity for statins to suppress the early stages of AD pathogenesis. JF - Aging Health AU - Li, Gail AU - Sonnen, Joshua A AU - Montine, Kathleen S AU - Montine, Thomas J AD - Department of Psychiatry & Behavioral Science, University of Washington, Seattle, WA 98104, USA and, Puget Sound Veterans Administration Health System, Seattle, WA, USA., gli@u.washington.edu Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 29 EP - 32 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 5 IS - 1 SN - 1745-509X, 1745-509X KW - Risk Abstracts KW - Reviews KW - Alzheimer's disease KW - Netherlands, Rotterdam KW - statins KW - Risk reduction KW - dementia disorders KW - clinical trials KW - aging KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1014108823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aging+Health&rft.atitle=Treatment+of+latent+stage+Alzheimer%27%27s+disease+with+statins%3F&rft.au=Li%2C+Gail%3BSonnen%2C+Joshua+A%3BMontine%2C+Kathleen+S%3BMontine%2C+Thomas+J&rft.aulast=Li&rft.aufirst=Gail&rft.date=2009-02-01&rft.volume=5&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Aging+Health&rft.issn=1745509X&rft_id=info:doi/10.2217%2F1745509X.5.1.29 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Number of references - 29 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Reviews; Alzheimer's disease; statins; dementia disorders; Risk reduction; clinical trials; aging; Netherlands, Rotterdam DO - http://dx.doi.org/10.2217/1745509X.5.1.29 ER - TY - JOUR T1 - Diminished Speech Intelligibility Associated with Certain Types of Respirators Worn by Healthcare Workers AN - 899151159; 15153536 AB - This study sought to determine the level of communication interference associated with commonly used disposable and reusable respirators and surgical masks worn by healthcare workers. Speech intelligibility was assessed using the modified rhyme test in an intensive care unit environment. Respirators decreased speech intelligibility by a range of 1% to 17%, although not all were statistically significant. Differences in speech intelligibility associated with surgical masks and disposable filtering facepiece respirators (without exhalation valves) were not statistically significant compared with controls. Wearing half-face elastomeric respirators with voice augmentation equipment was associated with higher speech intelligibility than models without this equipment (OR = 2.81). Hearing clarity while wearing a powered air-purifying respirator (PAPR) was 79% compared with 90% with no PAPR (OR = 0.40). While some respirators appear to have little or no effect on speech intelligibility, interference with speech intelligibility associated with certain types of respirators commonly worn by U.S. healthcare workers may be substantial. JF - Journal of Occupational and Environmental Hygiene AU - Radonovich, Lewis J, Jr AU - Yanke, Robert AU - Cheng, Jing AU - Bender, Bradley AD - National Center for Occupational Health and Infection Control, Veterans Health Administration, Gainesville, Florida Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - USA KW - Communications KW - Respirators KW - Protective equipment KW - Occupational exposure KW - Medical personnel KW - surgery KW - intensive care units KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899151159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Diminished+Speech+Intelligibility+Associated+with+Certain+Types+of+Respirators+Worn+by+Healthcare+Workers&rft.au=Radonovich%2C+Lewis+J%2C+Jr%3BYanke%2C+Robert%3BCheng%2C+Jing%3BBender%2C+Bradley&rft.aulast=Radonovich&rft.aufirst=Lewis&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620903404803 L2 - http://www.informaworld.com/smpp/content~db=all~content=a916721975~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Communications; Respirators; Protective equipment; surgery; Medical personnel; Occupational exposure; intensive care units; USA DO - http://dx.doi.org/10.1080/15459620903404803 ER - TY - JOUR T1 - Hearing loss in veterans and the need for hearing loss prevention programs. AN - 85390857; pmid-19265249 AB - Currently, there are more than 445,000 veterans receiving compensation for hearing loss associated with military service, and 395,000 receiving compensation for service-related tinnitus. In addition to compensation payments, service-related hearing disorders cost the US Department of Veterans Affairs in terms of provision of hearing aids, hearing aid-related services, and clinical services at its 220 facilities nationwide. It is imperative that hearing conservation among military personnel and veterans be addressed. In this paper, we describe the rationale for and the development of a multimedia Hearing Loss Prevention Program aimed at preventing the progression of hearing loss among veterans associated with social, recreational, and nonmilitary occupational noise exposure. The program was developed based on the principles outlined in the Health Belief Model of Rosenstock (1966) and the Health Promotion Model of Pender et al. (2002). JF - Noise & health AU - Saunders, Gabrielle H AU - Griest, Susan E AD - National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Portland, OR, USA. gabrielle.saunders@va.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 14 EP - 21 VL - 11 IS - 42 SN - 1463-1741, 1463-1741 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Ear Protective Devices KW - Health Behavior KW - Health Education KW - Hearing Aids: economics KW - Hearing Loss, Noise-Induced: economics KW - *Hearing Loss, Noise-Induced: epidemiology KW - *Hearing Loss, Noise-Induced: prevention & control KW - Hearing Loss, Noise-Induced: psychology KW - Humans KW - Middle Aged KW - National Institute for Occupational Safety and Health (U.S.) KW - *Noise, Occupational: prevention & control KW - Noise, Transportation KW - Prevalence KW - Tinnitus: economics KW - *Tinnitus: prevention & control KW - United States KW - *United States Department of Veterans Affairs: economics KW - *Veterans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85390857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+%26+health&rft.atitle=Hearing+loss+in+veterans+and+the+need+for+hearing+loss+prevention+programs.&rft.au=Saunders%2C+Gabrielle+H%3BGriest%2C+Susan+E&rft.aulast=Saunders&rft.aufirst=Gabrielle&rft.date=2009-01-01&rft.volume=11&rft.issue=42&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Noise+%26+health&rft.issn=14631741&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Protein fixation and antigen retrieval: chemical studies AN - 745607029; 12802748 AB - Fixation with formaldehyde is the first process to which most biopsy and necropsy specimens are exposed prior to dehydration and embedding in paraffin wax. Tissue specimens that have been fixed in formaldehyde have architectural characteristics that are familiar to virtually every pathologist and these facilitate routine diagnosis. Nevertheless, formaldehyde fixation has some deleterious effects including reduction in immunoreactivity and degradation of nucleic acids. Development of methods to counteract these deleterious effects requires an understanding of the chemical events that occur during tissue fixation and subsequent tissue processing. This short review illustrates some of the chemical consequences of formaldehyde fixation and ethanol dehydration. It also provides some insight into the molecular events accompanying heat-induced antigen retrieval. JF - Biotechnic and Histochemistry AU - O'Leary, T J AU - Fowler, C B AU - Evers, DI AU - Mason, J T AD - Office of Research and Development, Veterans Health Administration, Department of Veterans Affairs, Washington, DC, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 217 EP - 221 VL - 84 IS - 5 SN - 1052-0295, 1052-0295 KW - Biotechnology and Bioengineering Abstracts KW - Autopsy KW - Paraffin KW - nucleic acids KW - Reviews KW - Immunoreactivity KW - Formaldehyde KW - Proteins KW - Biopsy KW - Embedding KW - Dehydration KW - Ethanol KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745607029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnic+and+Histochemistry&rft.atitle=Protein+fixation+and+antigen+retrieval%3A+chemical+studies&rft.au=O%27Leary%2C+T+J%3BFowler%2C+C+B%3BEvers%2C+DI%3BMason%2C+J+T&rft.aulast=O%27Leary&rft.aufirst=T&rft.date=2009-01-01&rft.volume=84&rft.issue=5&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Biotechnic+and+Histochemistry&rft.issn=10520295&rft_id=info:doi/10.1080%2F10520290903039086 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Autopsy; Paraffin; nucleic acids; Reviews; Immunoreactivity; Proteins; Formaldehyde; Biopsy; Embedding; Ethanol; Dehydration DO - http://dx.doi.org/10.1080/10520290903039086 ER - TY - JOUR T1 - The Veterans Health Administration's (VHA's) Polytrauma System of Care for mild traumatic brain injury: costs, benefits, and controversies. AN - 742776828; pmid-19158591 AB - The Veterans Health Administration's (VHA's) Polytrauma System of Care, developed in response to a new cohort of patients back from Iraq and Afghanistan, is described with particular focus on the assessment and treatment of mild traumatic brain injury (mild TBI). The development of systemwide TBI screening within the VHA has been an ambitious and historic undertaking. As with any population-wide screening tool, there are benefits and costs associated with it. The purpose of this article is to identify and discuss the strengths and weaknesses of the VHA's TBI clinical reminder and subsequent evaluation and treatment processes. Complicating factors such as increased media attention and other contextual factors are discussed. JF - The Journal of head trauma rehabilitation AU - Belanger, Heather G AU - Uomoto, Jay M AU - Vanderploeg, Rodney D AD - Department of Psychology, James A.Haley VeteransHospital, 13000 Bruce B Downs Blvd, 117, Tampa, FL 33612, USA. Heather.Belanger@va.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 4 EP - 13 VL - 24 IS - 1 SN - 0885-9701, 0885-9701 KW - Index Medicus KW - National Library of Medicine KW - Veterans KW - Reproducibility of Results KW - Humans KW - Data Collection KW - Trauma Severity Indices KW - Medical Records Systems, Computerized KW - Brain Injuries -- economics KW - Decision Support Systems, Clinical KW - Health Care Costs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742776828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+head+trauma+rehabilitation&rft.atitle=The+Veterans+Health+Administration%27s+%28VHA%27s%29+Polytrauma+System+of+Care+for+mild+traumatic+brain+injury%3A+costs%2C+benefits%2C+and+controversies.&rft.au=Belanger%2C+Heather+G%3BUomoto%2C+Jay+M%3BVanderploeg%2C+Rodney+D&rft.aulast=Belanger&rft.aufirst=Heather&rft.date=2009-01-01&rft.volume=24&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+head+trauma+rehabilitation&rft.issn=08859701&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Cognitive sequelae of blast-related versus other mechanisms of brain trauma. AN - 742776528; pmid-19128523 AB - The use of improvised explosive devices has become the hallmark of modern warfare and has resulted in an ever-increasing number of blast-related traumatic brain injuries (TBIs). Despite this fact, very little is actually known about the cognitive sequelae of blast-related TBIs. The purpose of the current study was to compare patterns of performance on neuropsychological measures in subjects who have sustained TBIs as a result of blast (or explosion) with those who have sustained TBIs from non-blast or blunt force trauma (motor vehicle accident, fall, assault, etc.). Participants were categorized as blast-related TBI or non-blast-related TBI and according to severity of injury (mild or moderate-to-severe). No main effects were observed in analysis of covariance between blast-related TBI participants and non-blast-related TBI participants across any of the neuropsychological variables, although an interaction was observed on a visual memory test showing stronger performance for mild blast-related and poorer performance for moderate-to-severe blast-related participants compared with both non-blast groups. Overall, the results do not provide any strong evidence that blast is categorically different from other TBI mechanisms, at least with regard to cognitive sequelae on select measures. Additional findings included a marginally increased incidence of reported posttraumatic stress disorder symptoms among blast-injured participants. (JINS, 2009, 15, 1-8.). JF - Journal of the International Neuropsychological Society : JINS AU - Belanger, Heather G AU - Kretzmer, Tracy AU - Yoash-Gantz, Ruth AU - Pickett, Treven AU - Tupler, Larry A AD - Department of Mental Health and Behavioral Sciences, James A. Haley Veterans Hospital, Tampa, Florida. heather.belanger@va.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 1 EP - 8 VL - 15 IS - 1 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Blast Injuries -- psychology KW - Humans KW - Learning -- physiology KW - Memory -- physiology KW - Blast Injuries -- complications KW - Psychomotor Performance -- physiology KW - Psychiatric Status Rating Scales KW - Brain Injuries -- psychology KW - Adult KW - Neuropsychological Tests KW - Female KW - Brain Injuries -- complications KW - Male KW - Cognition Disorders -- etiology KW - Cognition Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742776528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Cognitive+sequelae+of+blast-related+versus+other+mechanisms+of+brain+trauma.&rft.au=Belanger%2C+Heather+G%3BKretzmer%2C+Tracy%3BYoash-Gantz%2C+Ruth%3BPickett%2C+Treven%3BTupler%2C+Larry+A&rft.aulast=Belanger&rft.aufirst=Heather&rft.date=2009-01-01&rft.volume=15&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - The potential utility of driving simulators in the cognitive rehabilitation of combat-returnees with traumatic brain injury. AN - 742775844; pmid-19158596 AB - A large number of Operation Enduring Freedom/Operation Iraqi Freedom returnees are seeking DOD and VA rehabilitative care for war-related traumatic brain injury (TBI). This article reviews evidence on the utility of driving simulators as tools for assessment and training in TBI rehabilitation. Traditionally, cognitive rehabilitation has been shown to improve specific cognitive skills. However, there are few studies and only weak evidence to show that these gains transfer to everyday activities. Theoretically, modern driving simulators may be useful in cognitive rehabilitation because they can systematically present realistic and interesting tasks that approximate driving activities, while automatically monitoring performance. The use of simulation technology for patients with TBI provides cognitive stimulation in an ecologically compatible setting, without the risks associated with a corresponding real-world experience. The utility, limitations, and future directions for the use of driving simulator in the rehabilitation of patients with war-related TBI are discussed. JF - The Journal of head trauma rehabilitation AU - Lew, Henry L AU - Rosen, Peter N AU - Thomander, Darryl AU - Poole, John H AD - Veterans Affairs Boston Health Care System, 150 South Huntington Ave, Boston, MA 02130, USA. henry.lew@va.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 51 EP - 56 VL - 24 IS - 1 SN - 0885-9701, 0885-9701 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Cognitive Therapy KW - Brain Injuries -- psychology KW - Military Personnel UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742775844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+head+trauma+rehabilitation&rft.atitle=The+potential+utility+of+driving+simulators+in+the+cognitive+rehabilitation+of+combat-returnees+with+traumatic+brain+injury.&rft.au=Antai-Otong%2C+Deborah&rft.aulast=Antai-Otong&rft.aufirst=Deborah&rft.date=2006-05-01&rft.volume=42&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+psychiatric+care&rft.issn=00315990&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - The cognitive effects of hepatitis C in the presence and absence of a history of substance use disorder. AN - 742775614; pmid-19128530 AB - The aim of the study was to determine whether infection with the hepatitis C virus (HCV) is associated with cognitive impairment beyond the effects of prevalent comorbidities and a history of substance use disorder (SUD). Adult veterans were recruited from the Portland Veterans Affairs Medical Center into three groups: (1) HCV+/SUD+ (n = 39), (2) HCV+/SUD- (n = 24), and (3) HCV-/SUD- (n = 56). SUD+ participants were in remission for > or =90 days, while SUD- participants had no history of SUD. Groups did not significantly differ in terms of rates of psychiatric or medical comorbidities. Procedures included clinical interviews, medical record reviews, and neuropsychological testing. Significant group differences were found in the domains of Verbal Memory, Auditory Attention, Speeded Visual Information Processing, and Reasoning/Mental Flexibility (p =85%. Treatment with doxorubicin+vincristine activated the prosurvival signal Akt and diminished cytochrome C release. The PI3K/Akt inhibitor LY294002 and the MEK/ERK inhibitor PD98059 augmented doxorubicin cardiotoxicity and attenuated salvage during concurrent vincristine treatment, indicating that the mechanism of vincristine cardioprotection involves activation of specific survival signals. Vincristine retarded the onset of apoptosis in association with a delay in poly(ADP) ribose polymerase activation. Vincristine also exhibited greater protection than the antioxidant MPG. These novel findings may have clinical implications for the prevention of doxorubicin cardiomyopathy. JF - Biochemical and Biophysical Research Communications AU - Chatterjee, K AU - Zhang, J AU - Tao, R AU - Honbo, N AU - Karliner, J S AD - VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA, Joel.Karliner@med.va.gov Y1 - 2008/09/05/ PY - 2008 DA - 2008 Sep 05 SP - 555 EP - 560 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 373 IS - 4 SN - 0006-291X, 0006-291X KW - Toxicology Abstracts KW - Myocytes KW - Antioxidants KW - Apoptosis KW - Ribose KW - Survival KW - Vincristine KW - cardiomyocytes KW - Doxorubicin KW - Extracellular signal-regulated kinase KW - Cardiomyopathy KW - Alkaloids KW - 1-Phosphatidylinositol 3-kinase KW - Cytochrome c KW - AKT protein KW - Vinca KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20895241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Vincristine+attenuates+doxorubicin+cardiotoxicity&rft.au=Chatterjee%2C+K%3BZhang%2C+J%3BTao%2C+R%3BHonbo%2C+N%3BKarliner%2C+J+S&rft.aulast=Chatterjee&rft.aufirst=K&rft.date=2008-09-05&rft.volume=373&rft.issue=4&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2008.06.067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Myocytes; Apoptosis; Antioxidants; Ribose; Vincristine; Survival; cardiomyocytes; Doxorubicin; Cardiomyopathy; Extracellular signal-regulated kinase; 1-Phosphatidylinositol 3-kinase; Alkaloids; Cytochrome c; AKT protein; Vinca DO - http://dx.doi.org/10.1016/j.bbrc.2008.06.067 ER - TY - JOUR T1 - A Pilot Study of Posttraumatic Stress and Associated Functioning of Army National Guard Following Exposure to Iraq Warzone Trauma AN - 877592525; 13642429 AB - This study examines the experiences of a convenience sample of Army National Guard soldiers who were combat exposed during the Iraq War. Thirty-one men volunteered to complete an interview and questionnaires during training weekends. Participants reported significant posttraumatic stress disorder (PTSD) symptoms (68% reported re-experiencing and 93% hyperarousal symptoms) based on a PTSD research interview. PTSD severity was associated with more alcohol consumption, illicit drug use, and poorer mental health functional status. These data suggest that combat-exposed soldiers may be at risk for significant PTSD symptoms, higher consumption of substances, and decreased quality of life. JF - Traumatology AU - Ouimette, Paige AU - Coolhart, Deborah AU - Sugarman, Dawn AU - Funderburk, Jennifer S AU - Zelman, Russell H AU - Dornau, Carolee AD - VA Center for Integrated Healthcare, Syracuse VA Medical Center, Syracuse, NY, Paigec.ouimette@med.va.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 51 EP - 56 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 14 IS - 3 SN - 1534-7656, 1534-7656 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877592525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traumatology&rft.atitle=A+Pilot+Study+of+Posttraumatic+Stress+and+Associated+Functioning+of+Army+National+Guard+Following+Exposure+to+Iraq+Warzone+Trauma&rft.au=Ouimette%2C+Paige%3BCoolhart%2C+Deborah%3BSugarman%2C+Dawn%3BFunderburk%2C+Jennifer+S%3BZelman%2C+Russell+H%3BDornau%2C+Carolee&rft.aulast=Ouimette&rft.aufirst=Paige&rft.date=2008-09-01&rft.volume=14&rft.issue=3&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F1534765608320330 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1177/1534765608320330 ER - TY - JOUR T1 - Adjusting alcohol quantity for mean consumption and intoxication threshold improves prediction of nonadherence in HIV patients and HIV-negative controls. AN - 69639237; 18616666 AB - Screening for hazardous drinking may fail to detect a substantial proportion of individuals harmed by alcohol. We investigated whether considering an individual's usual drinking quantity or threshold for alcohol-induced cognitive impairment improves the prediction of nonadherence with prescribed medications. Cross-sectional analysis of participants in a large, multi-site cohort study. We used the timeline followback to reconstruct 30-day retrospective drinking histories and the timeline followback modified for adherence to reconstruct 30-day medication adherence histories among 3,152 individuals in the Veterans Aging Cohort Study, 1,529 HIV infected and 1,623 uninfected controls. We categorized daily alcohol consumption by using quantity alone, quantity after adjustment for the individual's mean daily alcohol consumption, and self-reported level of impairment corresponding to each quantity. A standard drink was defined as 14 g of ethanol. Nonadherence was defined as the proportion of days with > or =1 medication doses missed or taken > or =2 hours late, and clinically significant nonadherence was defined as > or =5% absolute increase in the proportion of days with nonadherence. The mean adjusted- and impairment-based methods showed greater discrimination of nonadherence risk compared to the measure based on quantity alone (quantity-based categorization, 3.2-fold increase; quantity adjusted for mean daily consumption, 4.6-fold increase, impairment-based categorization, 3.6-fold increase). The individualized methods also detected greater numbers of days with clinically significant nonadherence associated with alcohol. Alcohol was associated with clinically significant nonadherence at a lower threshold for HIV infected versus uninfected patients (2 standard drinks vs. 4 standard drinks) using quantity-based categorization, but this difference was no longer apparent when individualized methods were used. Tailoring screening questions to an individual's usual level of alcohol consumption or threshold for impairment improves the ability to predict alcohol-associated medication nonadherence. JF - Alcoholism, clinical and experimental research AU - Braithwaite, R Scott AU - Conigliaro, Joseph AU - McGinnis, Kathleen A AU - Maisto, Stephen A AU - Bryant, Kendall AU - Justice, Amy C AD - Department of Medicine, Section of General Internal Medicine, Yale University School of Medicine and Connecticut Veterans Administration Medical Center, West Haven, Connecticut 06516, USA. ronald.braithwaite@med.va.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1645 EP - 1651 VL - 32 IS - 9 KW - Anti-HIV Agents KW - 0 KW - Index Medicus KW - Mass Screening KW - Cross-Sectional Studies KW - Humans KW - Cohort Studies KW - Case-Control Studies KW - Predictive Value of Tests KW - Cognition Disorders -- psychology KW - Alcoholic Intoxication -- psychology KW - Alcoholic Intoxication -- diagnosis KW - Anti-HIV Agents -- therapeutic use KW - Medication Adherence -- statistics & numerical data KW - HIV Infections -- drug therapy KW - Alcohol Drinking -- psychology KW - Medication Adherence -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69639237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Adjusting+alcohol+quantity+for+mean+consumption+and+intoxication+threshold+improves+prediction+of+nonadherence+in+HIV+patients+and+HIV-negative+controls.&rft.au=Braithwaite%2C+R+Scott%3BConigliaro%2C+Joseph%3BMcGinnis%2C+Kathleen+A%3BMaisto%2C+Stephen+A%3BBryant%2C+Kendall%3BJustice%2C+Amy+C&rft.aulast=Braithwaite&rft.aufirst=R&rft.date=2008-09-01&rft.volume=32&rft.issue=9&rft.spage=1645&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=1530-0277&rft_id=info:doi/10.1111%2Fj.1530-0277.2008.00732.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-22 N1 - Date created - 2008-10-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet Infect Dis. 2004 Jul;4(7):437-44 [15219554] Alcohol Clin Exp Res. 2004 Apr;28(4):572-7 [15100608] J Stud Alcohol. 1988 May;49(3):225-32 [3374136] Br J Addict. 1988 Apr;83(4):393-402 [3395719] AIDS. 1998 Oct 1;12(14):1735-44 [9792373] Med Care. 1999 Feb;37(2):165-79 [10024121] Arch Intern Med. 1999 Aug 9-23;159(15):1681-9 [10448769] Alcohol Clin Exp Res. 2005 Jul;29(7):1190-7 [16046874] Med Care. 2006 Aug;44(8 Suppl 2):S13-24 [16849964] AIDS Care. 2007 Apr;19(4):459-66 [17453583] Ann Intern Med. 2000 Jul 4;133(1):21-30 [10877736] Compr Psychiatry. 2000 Mar-Apr;41(2 Suppl 1):95-103 [10746911] AIDS. 2007 Jul 31;21(12):1579-89 [17630553] J Geriatr Psychiatry Neurol. 2000 Fall;13(3):106-14 [11001132] Alcohol Clin Exp Res. 2001 Jan;25(1):136-44 [11198709] J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56 [11253156] J Fam Pract. 2001 Apr;50(4):313-20 [11300982] Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):189S-196S [11391070] Psychol Addict Behav. 2001 Dec;15(4):310-6 [11767262] Psychol Addict Behav. 2001 Dec;15(4):317-20 [11767263] N Engl J Med. 2002 Mar 14;346(11):811-20 [11893792] J Gerontol A Biol Sci Med Sci. 2002 May;57(5):M283-8 [11983721] J Stud Alcohol. 1982 Nov;43(11):1157-70 [7182675] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1530-0277.2008.00732.x ER - TY - JOUR T1 - Prominent neuroleptic sensitivity in a case of early-onset Alzheimer disease due to presenilin-1 G206A mutation. AN - 69553408; 18797263 AB - We describe atypical motor and cognitive features in a case of familial Alzheimer disease (FAD) due to presenilin-1 (PS-1) mutation. Extrapyramidal signs (EPS) typically are a late-presenting feature of sporadic Alzheimer disease (AD), but relatively little data are available regarding EPS in FAD. A 59-year-old, right-handed man of Caribbean-Hispanic descent underwent brain imaging studies, laboratory tests for AD, and serial neurologic and neuropsychologic evaluations. The patient presented with recent-onset delusional ideation associated with cognitive decline. Prominent EPS developed soon after initiation of an atypical neuroleptic agent. Neuropsychologic evaluation revealed global cognitive deficits; he was found to be a carrier of a PS-1 point mutation at position G206A. EPS resolved completely after discontinuing the neuroleptic agent and coincided with improved motor speed, set initiation, and verbal fluency. Severe neuroleptic sensitivity and associated deficits of cognitive speed occurred in response to a dopaminergic antagonist agent; both responded readily to withdrawal of the offending agent. Patients with PS-1 AD may be at substantially increased risk of neuroleptic-induced EPS. That feature underscores the heterogeneity of the FAD clinical phenotype. JF - Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology AU - Cercy, Steven P AU - Sadowski, Martin J AU - Wisniewski, Thomas AD - Memory Disorders Clinic, Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, USA. steven.cercy@va.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 190 EP - 195 VL - 21 IS - 3 KW - Antipsychotic Agents KW - 0 KW - Presenilin-1 KW - Index Medicus KW - Pedigree KW - Humans KW - DNA Mutational Analysis KW - Middle Aged KW - Male KW - Basal Ganglia Diseases -- chemically induced KW - Point Mutation -- genetics KW - Alzheimer Disease -- genetics KW - Drug Hypersensitivity -- etiology KW - Alzheimer Disease -- physiopathology KW - Alzheimer Disease -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Presenilin-1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69553408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cognitive+and+behavioral+neurology+%3A+official+journal+of+the+Society+for+Behavioral+and+Cognitive+Neurology&rft.atitle=Prominent+neuroleptic+sensitivity+in+a+case+of+early-onset+Alzheimer+disease+due+to+presenilin-1+G206A+mutation.&rft.au=Cercy%2C+Steven+P%3BSadowski%2C+Martin+J%3BWisniewski%2C+Thomas&rft.aulast=Cercy&rft.aufirst=Steven&rft.date=2008-09-01&rft.volume=21&rft.issue=3&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Cognitive+and+behavioral+neurology+%3A+official+journal+of+the+Society+for+Behavioral+and+Cognitive+Neurology&rft.issn=1543-3641&rft_id=info:doi/10.1097%2FWNN.0b013e31817d74bf LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-17 N1 - Date created - 2008-09-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/WNN.0b013e31817d74bf ER - TY - JOUR T1 - Treatment staff's continuity of care practices, patients' engagement in continuing care, and abstinence following outpatient substance-use disorder treatment. AN - 69538309; 18781250 AB - Although speculation suggests that continuity of care predicts abstinence following substance-use disorder (SUD) treatment, models examining staff's continuity of care practices and engagement in continuing care and whether they mediate or moderate the association between patient and treatment factors and abstinence are lacking. In this study, we aimed to model abstinence using combinations of independent pretreatment and treatment factors, discharge continuity of care practices, and posttreatment engagement and to identify mediators or moderators of relationships between these factors and abstinence. Staff in 18 Department of Veterans Affairs (VA) outpatient SUD programs used the Addiction Severity Index to assess 429 nonabstinent patients' alcohol and drug problems at treatment entry. Staff supplied discharge data on patients' motivation, treatment intensity and completion, and continuity of care practices. Administrative data assessed patients' continuing care engagement. A 6-month follow-up, the Addiction Severity Index assessed abstinence. Mixed-effects logistic regression models were used to examine predictors of abstinence. Abstinence occurred more when discharge plans specified at least one continuing care appointment per week, patients received continuing care appointments before discharge, and staff provided patients drug-free/sober living arrangements and with longer engagement in continuing care. SUD/psychiatric clinic use before treatment entry, treatment completion, access to transportation for continuing care appointments, and more patient motivation for continuing care also predicted abstinence. Engagement in continuing care mediated the relationship between continuity of care and abstinence and between SUD/psychiatric clinic use and abstinence. Findings suggest that continuity of care practices influence abstinence mostly through their effect on patients' engagement in continuing care. JF - Journal of studies on alcohol and drugs AU - Schaefer, Jeanne A AU - Harris, Alex H S AU - Cronkite, Ruth C AU - Turrubiartes, Patricia AD - Center for Health Care Evaluation, Department of Veterans Affairs Palo Alto Health Care System, 795 Willow Road (152), Menlo Park, California 94025, USA. Jeanne.Schaefer@va.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 747 EP - 756 VL - 69 IS - 5 SN - 1937-1888, 1937-1888 KW - Index Medicus KW - United States KW - Outpatients KW - Severity of Illness Index KW - Quality of Health Care KW - Humans KW - Logistic Models KW - United States Department of Veterans Affairs KW - Adult KW - Treatment Outcome KW - Follow-Up Studies KW - Middle Aged KW - Time Factors KW - Female KW - Male KW - Continuity of Patient Care -- organization & administration KW - Substance Abuse Treatment Centers -- organization & administration KW - Continuity of Patient Care -- standards KW - Substance Abuse Treatment Centers -- standards KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69538309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol+and+drugs&rft.atitle=Treatment+staff%27s+continuity+of+care+practices%2C+patients%27+engagement+in+continuing+care%2C+and+abstinence+following+outpatient+substance-use+disorder+treatment.&rft.au=Schaefer%2C+Jeanne+A%3BHarris%2C+Alex+H+S%3BCronkite%2C+Ruth+C%3BTurrubiartes%2C+Patricia&rft.aulast=Schaefer&rft.aufirst=Jeanne&rft.date=2008-09-01&rft.volume=69&rft.issue=5&rft.spage=747&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol+and+drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-21 N1 - Date created - 2008-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gender differences in social influences and stressors linked to increased drinking. AN - 69531551; 18781244 AB - To explore reasons for gender differences in problem-drinking prevalence and to compare the experiences of problem-drinking women and men, this article examines gender differences in exposure and drinking reactivity to social influences and stressors during adulthood. A community sample of 831 older adults (347 women and 484 men; average age=69), comprising problem and nonproblem drinkers, provided information about their drinking histories. Respondents indicated whether they had experienced particular social influences and stressors during adulthood (exposure) and, if so, whether they had increased alcohol consumption in response (reactivity). Overall, women were more likely than men to report exposure to a partner's drinking, family interpersonal problems, death of someone close, and emotional distress. Men reported more exposure to peers' drinking and workplace problems and were more likely to report drinking reactivity to social influences and stressors. Among problem drinkers, gender differences in exposure to social influences and stressors paralleled those in the overall sample, but gender differences in reactivity were minimal. Gender differences in exposure to social influences and stressors generally do not help explain men's higher problem-drinking prevalence, but men's overall greater drinking reactivity corresponds with their propensity to develop problem drinking. Problem-drinking women and men tend to be exposed to somewhat different social influences and stressors but share a tendency to respond to these experiences with increased drinking. Information about experiences that may place upward pressure on drinking for men and women can inform efforts to prevent and treat alcohol-use disorders. JF - Journal of studies on alcohol and drugs AU - Lemke, Sonne AU - Schutte, Kathleen K AU - Brennan, Penny L AU - Moos, Rudolf H AD - Center for Health Care Evaluation (152MPD), Veterans Affairs Palo Alto Health Care System, 795 Willow Road, Menlo Park, California 94025, USA. Sonne.Lemke@va.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 695 EP - 702 VL - 69 IS - 5 SN - 1937-1888, 1937-1888 KW - Index Medicus KW - Cross-Sectional Studies KW - Sex Factors KW - Humans KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Longitudinal Studies KW - Male KW - Female KW - Stress, Psychological KW - Alcohol Drinking -- psychology KW - Social Facilitation KW - Alcohol-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69531551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol+and+drugs&rft.atitle=Gender+differences+in+social+influences+and+stressors+linked+to+increased+drinking.&rft.au=Lemke%2C+Sonne%3BSchutte%2C+Kathleen+K%3BBrennan%2C+Penny+L%3BMoos%2C+Rudolf+H&rft.aulast=Lemke&rft.aufirst=Sonne&rft.date=2008-09-01&rft.volume=69&rft.issue=5&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol+and+drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-21 N1 - Date created - 2008-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addiction. 1999 May;94(5):737-49 [10563039] J Stud Alcohol Drugs. 2007 May;68(3):437-45 [17446984] J Stud Alcohol. 2000 Sep;61(5):669-73 [11022805] Alcohol Clin Exp Res. 2000 Nov;24(11):1666-79 [11104114] Am J Psychiatry. 2001 Apr;158(4):587-93 [11282693] Addict Behav. 2001 Mar-Apr;26(2):181-99 [11316376] Psychol Med. 2001 May;31(4):593-604 [11352362] J Stud Alcohol. 2001 Sep;62(5):637-45 [11702803] J Stud Alcohol Suppl. 2002 Mar;(14):40-53 [12022729] J Stud Alcohol. 2002 Jul;63(4):486-97 [12160108] Addict Behav. 2003 Jan-Feb;28(1):171-87 [12507535] Psychol Addict Behav. 2003 Jun;17(2):115-25 [12814275] Psychol Aging. 1990 Mar;5(1):31-40 [2180432] Psychol Aging. 1990 Dec;5(4):491-501 [2278671] J Stud Alcohol. 1991 Jul;52(4):325-30 [1875705] Br J Addict. 1991 Sep;86(9):1139-50 [1932886] J Abnorm Psychol. 1992 Feb;101(1):139-52 [1537960] J Subst Abuse. 1991;3(4):395-404 [1821293] J Health Soc Behav. 1993 Mar;34(1):71-88 [8463637] Alcohol Clin Exp Res. 1993 Dec;17(6):1146-55 [8116823] Addict Behav. 1993 Nov-Dec;18(6):659-70 [8178704] J Health Soc Behav. 1994 Dec;35(4):291-308 [7844327] J Pers Soc Psychol. 1995 Nov;69(5):990-1005 [7473043] J Clin Psychol. 1997 Apr;53(3):263-77 [9075055] Arch Gen Psychiatry. 1997 Apr;54(4):313-21 [9107147] Alcohol Clin Exp Res. 1998 Sep;22(6):1349-58 [9756052] Am J Community Psychol. 1999 Feb;27(1):25-54 [10234802] Psychiatr Clin North Am. 1999 Jun;22(2):241-52 [10385931] Clin Psychol Rev. 2004 Dec;24(8):981-1010 [15533281] Psychol Addict Behav. 2004 Dec;18(4):334-9 [15631605] Alcohol Clin Exp Res. 2005 Apr;29(4):612-21 [15834227] Alcohol Alcohol. 2005 Sep-Oct;40(5):453-60 [15972275] Addict Behav. 1999 Nov-Dec;24(6):839-56 [10628517] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Promising survival in patients with recurrent non-small cell lung cancer treated with docetaxel and gemcitabine in combination as second-line therapy. AN - 69491367; 18758307 AB - Lung cancer is the leading cause of cancer death in men and women, and current second-line chemotherapy regimens yield relatively poor response and survival rates. We hypothesized that the combination of weekly docetaxel (D) and gemcitabine (G) would show activity in the second-line setting. We therefore conducted a phase II trial evaluating this regimen in patients with relapsed or progressive non-small cell lung cancer (NSCLC) after first-line platinum-based therapy. Patients with recurrent NSCLC, adequate physiologic indices, and exposure to one prior platinum-based regimen were eligible. Docetaxel 40 mg/m intravenous (IV) and gemcitabine (G) 800 mg/m IV weekly were administered on day 1 and 8 every 21 days. In the absence of dose-limiting toxicity, G was escalated on an intrapatient basis to 1 g/m/wk. The primary endpoint was response rate (RR); event-free (EFS) and overall survival were secondary endpoints. Thirty-five patients (median age 61 years; 20 [57%] male) were accrued. Most (88%) had previously received carboplatin/paclitaxel, 31.4% in combination with a third investigational agent, more than half (57.1%) had prior radiation. The median number of cycles was four. RR was 23%. Median EFS was 5.7 months and median overall survival was 12.5 months. Patients who had their cancer diagnosed more than or equal to 12 months before entering the trial had superior EFS (13.7 months versus 4.8 months). Toxicity was acceptable. There were no treatment-related deaths. A nonplatinum doublet with GD is feasible and effective in the treatment of recurrent, platinum-exposed NSCLC patients. RR and survival are promising. JF - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer AU - Huang, Chao Hui AU - Millenson, Michael M AU - Sherman, Eric J AU - Borghaei, Hossein AU - Mintzer, David M AU - Cohen, Roger B AU - Staddon, Arthur P AU - Seldomridge, Judi AU - Treat, Ocn Joseph AU - Tuttle, Holly AU - Ruth, Karen J AU - Langer, Corey J AD - University of Kansas Medical Center, Veterans Administration Medical Center, Kansas City, Missouri, USA. chuang2@kumc.edu Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1032 EP - 1038 VL - 3 IS - 9 KW - Taxoids KW - 0 KW - Deoxycytidine KW - 0W860991D6 KW - docetaxel KW - 15H5577CQD KW - gemcitabine KW - B76N6SBZ8R KW - Index Medicus KW - Survival Rate KW - Neoplasm Staging KW - Humans KW - Deoxycytidine -- analogs & derivatives KW - Salvage Therapy KW - Adult KW - Prognosis KW - Deoxycytidine -- administration & dosage KW - Aged KW - Middle Aged KW - Male KW - Female KW - Taxoids -- administration & dosage KW - Neoplasm Recurrence, Local -- drug therapy KW - Carcinoma, Non-Small-Cell Lung -- mortality KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Neoplasm Recurrence, Local -- pathology KW - Neoplasm Recurrence, Local -- mortality KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69491367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.atitle=Promising+survival+in+patients+with+recurrent+non-small+cell+lung+cancer+treated+with+docetaxel+and+gemcitabine+in+combination+as+second-line+therapy.&rft.au=Huang%2C+Chao+Hui%3BMillenson%2C+Michael+M%3BSherman%2C+Eric+J%3BBorghaei%2C+Hossein%3BMintzer%2C+David+M%3BCohen%2C+Roger+B%3BStaddon%2C+Arthur+P%3BSeldomridge%2C+Judi%3BTreat%2C+Ocn+Joseph%3BTuttle%2C+Holly%3BRuth%2C+Karen+J%3BLanger%2C+Corey+J&rft.aulast=Huang&rft.aufirst=Chao&rft.date=2008-09-01&rft.volume=3&rft.issue=9&rft.spage=1032&rft.isbn=&rft.btitle=&rft.title=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.issn=1556-1380&rft_id=info:doi/10.1097%2FJTO.0b013e31818307c2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-04 N1 - Date created - 2008-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/JTO.0b013e31818307c2 ER - TY - JOUR T1 - Preoperative use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers is associated with increased risk for acute kidney injury after cardiovascular surgery. AN - 69468440; 18667735 AB - Acute kidney injury (AKI) occurs commonly after cardiac surgery. Most patients who undergo cardiac surgery receive long-term treatment with angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB). The aim of this study was to determine whether long-term use of ACEI/ARB is associated with an increased incidence of AKI after cardiac surgery. This was a retrospective cohort study of 1358 adult patients who underwent cardiac surgery between January 1, 2001, and December 31, 2005, in two tertiary care hospitals in Buffalo, NY. The incidence of AKI was determined after cardiac surgery. Clinical data were collected using a standardized form that included comorbid condition, use of ACEI/ARB, and intraoperative and postoperative complications. Overall, 40.2% of patients developed AKI. Preoperative variables that were significantly associated with development of AKI included increasing age; nonwhite race; combined valve surgery and coronary artery bypass grafting compared with coronary artery bypass grafting alone; American Society of Anesthesiologists (ASA) Risk Score category 4/5 compared with 2 to 3; presence of diabetes, congestive heart failure, or neurologic disease at baseline; use of ACEI/ARB; and emergency surgery. Intra- and postoperative factors that were associated with postoperative AKI were hypotension during surgery, use of vasopressors, and postoperative hypotension. Multiple regression logistic model confirmed an independent and significant association of AKI and preoperative use of ACEI/ARB. This was confirmed using a bivariate-probit and propensity score model that adjusts for confounding by indication of use and selection bias. Preoperative use of ACEI/ARB is associated with a 27.6% higher risk for AKI postoperatively. Stopping ACEI or ARB before cardiac surgery may reduce the incidence of AKI. JF - Clinical journal of the American Society of Nephrology : CJASN AU - Arora, Pradeep AU - Rajagopalam, Srini AU - Ranjan, Rajiv AU - Kolli, Hari AU - Singh, Manpreet AU - Venuto, Rocco AU - Lohr, James AD - Division of Nephrology, Veterans Administration Medical Center, Buffalo, NY 14215, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1266 EP - 1273 VL - 3 IS - 5 KW - Angiotensin II Type 1 Receptor Blockers KW - 0 KW - Angiotensin-Converting Enzyme Inhibitors KW - Index Medicus KW - Acute Disease KW - Logistic Models KW - Risk Factors KW - Humans KW - Retrospective Studies KW - Incidence KW - Aged KW - Middle Aged KW - New York -- epidemiology KW - Male KW - Female KW - Risk Assessment KW - Cardiac Surgical Procedures -- statistics & numerical data KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Kidney Diseases -- etiology KW - Kidney Diseases -- epidemiology KW - Cardiac Surgical Procedures -- adverse effects KW - Kidney Diseases -- chemically induced KW - Angiotensin II Type 1 Receptor Blockers -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69468440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+journal+of+the+American+Society+of+Nephrology+%3A+CJASN&rft.atitle=Preoperative+use+of+angiotensin-converting+enzyme+inhibitors%2Fangiotensin+receptor+blockers+is+associated+with+increased+risk+for+acute+kidney+injury+after+cardiovascular+surgery.&rft.au=Arora%2C+Pradeep%3BRajagopalam%2C+Srini%3BRanjan%2C+Rajiv%3BKolli%2C+Hari%3BSingh%2C+Manpreet%3BVenuto%2C+Rocco%3BLohr%2C+James&rft.aulast=Arora&rft.aufirst=Pradeep&rft.date=2008-09-01&rft.volume=3&rft.issue=5&rft.spage=1266&rft.isbn=&rft.btitle=&rft.title=Clinical+journal+of+the+American+Society+of+Nephrology+%3A+CJASN&rft.issn=1555-905X&rft_id=info:doi/10.2215%2FCJN.05271107 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-18 N1 - Date created - 2008-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Kidney Int. 2000 Jun;57(6):2594-602 [10844629] Circulation. 2007 Sep 11;116(11 Suppl):I139-43 [17846294] Arch Intern Med. 2001 Jun 25;161(12):1492-9 [11427096] Circulation. 2001 Oct 16;104(16):1985-91 [11602506] Anesth Analg. 2001 Nov;93(5):1111-5 [11682377] Nephrol Dial Transplant. 2003 Jan;18(1):77-81 [12480963] J Hum Hypertens. 2003 Jun;17(6):419-23 [12764405] Stat Med. 2003 Jun 30;22(12):2057-70 [12802822] J Am Soc Nephrol. 2004 Jun;15(6):1597-605 [15153571] Anesthesiology. 1978 Oct;49(4):239-43 [697077] Am J Epidemiol. 1982 Jan;115(1):92-106 [7055134] Anesthesiology. 1990 Jan;72(1):23-7 [2404429] Br J Anaesth. 1996 May;76(5):632-9 [8688261] Circulation. 1997 Feb 18;95(4):878-84 [9054745] Am J Med. 1998 Apr;104(4):343-8 [9576407] Chest. 1998 Aug;114(2):487-94 [9726735] Stat Med. 1998 Sep 15;17(17):1943-58 [9777688] CMAJ. 1998 Nov 17;159(10):1279-81 [9861226] Nephrol Dial Transplant. 1999 May;14(5):1158-62 [10344355] Asian Cardiovasc Thorac Ann. 2004 Dec;12(4):346-9 [15585706] J Am Soc Nephrol. 2005 Jan;16(1):162-8 [15563569] Vascul Pharmacol. 2005 Feb;42(3):119-23 [15792929] Ann Thorac Surg. 2005 Oct;80(4):1388-93; discussion 1393 [16181876] Stat Med. 2006 Feb 15;25(3):389-413 [16382420] J Acquir Immune Defic Syndr. 2006 Apr 1;41(4):477-85 [16652057] Circulation. 2006 Jul 4;114(1 Suppl):I409-13 [16820609] Curr Opin Crit Care. 2006 Dec;12(6):531-7 [17077682] Circulation. 2006 Nov 21;114(21):2208-16; quiz 2208 [17088458] Nephron Clin Pract. 2007;105(2):c77-83 [17143010] Nat Clin Pract Nephrol. 2007 Aug;3(8):439-42 [17653122] Clin J Am Soc Nephrol. 2006 Jan;1(1):19-32 [17699187] Intensive Care Med. 2000 May;26(5):565-71 [10923731] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2215/CJN.05271107 ER - TY - JOUR T1 - Concurrent monitoring of psychological distress and satisfaction measures as predictors of addiction treatment retention. AN - 69346395; 18082998 AB - Dropout from addiction services is common, and strategies to improve retention represent potentially important opportunities for quality improvement and treatment effectiveness. Identification of pretreatment predictors of dropout has not led to advances in treatment delivery. Via telephone monitoring, we examined the feasibility and predictive validity of weekly assessment of psychological distress and treatment satisfaction as factors potentially associated with retention and engagement over the initial 8 weeks of treatment. Participants included 107 addiction treatment patients, of whom 78% met criteria for 4 weeks of engagement and 59% were retained for 8 weeks. Of 8 weekly assessments, 63% of participants completed six or more calls. Baseline distress, baseline satisfaction, and change in distress over 4 weeks were not related reliably to treatment dropout or engagement. Decrease in satisfaction was significantly but modestly associated with low engagement. Implications for applications of weekly monitoring to improve retention are discussed. JF - Journal of substance abuse treatment AU - Hawkins, Eric J AU - Baer, John S AU - Kivlahan, Daniel R AD - Center of Excellence in Substance Abuse Treatment and Education, VA Puget Sound Health Care System, Seattle, WA 98108, USA. eric.hawkins@va.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 207 EP - 216 VL - 35 IS - 2 KW - Index Medicus KW - Telephone KW - Humans KW - Adult KW - Middle Aged KW - Forecasting KW - Time Factors KW - Male KW - Patient Satisfaction KW - Stress, Psychological KW - Patient Dropouts -- psychology KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69346395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Concurrent+monitoring+of+psychological+distress+and+satisfaction+measures+as+predictors+of+addiction+treatment+retention.&rft.au=Hawkins%2C+Eric+J%3BBaer%2C+John+S%3BKivlahan%2C+Daniel+R&rft.aulast=Hawkins&rft.aufirst=Eric&rft.date=2008-09-01&rft.volume=35&rft.issue=2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=1873-6483&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-29 N1 - Date created - 2008-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The health encounter as a treatable moment for homeless substance-using adults: the role of homelessness, health seeking behavior, readiness for behavior change and motivation for treatment. AN - 69293629; 18562126 AB - Substance-using homeless persons frequent emergency departments and hospitals often. However, little is known about how homelessness affects when they seek care and their motivation for substance abuse treatment (SAT). We surveyed homeless (N=266) and non-homeless (N=104) substance-using adults sequentially admitted to an urban hospital medicine service, comparing demographics, readiness for change (URICA), and motivating reasons for SAT. Homeless respondents were more likely to be younger, uninsured, have hepatitis B/C, and <12th grade education. The majority in both groups were in either a precontemplative or contemplative stage of change, although more homeless respondents were in an action stage. They also had similar motivating reasons for wanting SAT, although being homeless was an additional motivator for the majority of homeless respondents. Almost half reported that being homeless caused them to delay seeking health care; paradoxically those citing physical health as a SAT motivator were 3.4 times more likely to have delayed care. While acutely ill homeless persons were at least as motivated for SAT, these data suggest the challenge is getting them to care in a timely manner and tailoring interventions during the care episode to avail of this motivation. JF - Addictive behaviors AU - O'Toole, Thomas P AU - Pollini, Robin A AU - Ford, Daniel E AU - Bigelow, George AD - Johns Hopkins Department of Medicine, United States. Thomas.O'Toole@va.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1239 EP - 1243 VL - 33 IS - 9 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Motivation KW - Humans KW - Adult KW - Health Behavior KW - Urban Health Services -- utilization KW - Middle Aged KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Homeless Persons -- statistics & numerical data KW - Patient Acceptance of Health Care -- statistics & numerical data KW - Homeless Persons -- psychology KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69293629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=The+health+encounter+as+a+treatable+moment+for+homeless+substance-using+adults%3A+the+role+of+homelessness%2C+health+seeking+behavior%2C+readiness+for+behavior+change+and+motivation+for+treatment.&rft.au=O%27Toole%2C+Thomas+P%3BPollini%2C+Robin+A%3BFord%2C+Daniel+E%3BBigelow%2C+George&rft.aulast=O%27Toole&rft.aufirst=Thomas&rft.date=2008-09-01&rft.volume=33&rft.issue=9&rft.spage=1239&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2008.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-16 N1 - Date created - 2008-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.addbeh.2008.04.015 ER - TY - JOUR T1 - Promoting continuing care adherence among substance abusers with co-occurring psychiatric disorders following residential treatment. AN - 69291371; 18573617 AB - Epidemiological data from treatment and community samples of individuals with substance use disorders indicate that the rates of co-occurring psychiatric disorders are high and that these disorders are associated with poor treatment adherence and outcomes. A growing body of research indicates that continuing care adherence interventions positively impact treatment outcome. However, it is unclear whether these interventions are effective for individuals with co-occurring psychiatric disorders. This paper explores this question with data from 150 participants who were randomized to receive a behavioral continuing care adherence intervention involving contracting, prompting and reinforcing attendance (CPR), or standard treatment. Fifty-one percent of the participants had one or more co-occurring Axis I or Axis II psychiatric disorders in addition to a SUD diagnosis. Among individuals with co-occurring disorders, those who received the CPR intervention show increased duration of treatment and improved 1-year abstinence rates compared to those who received STX. Additionally, effects of the CPR intervention were generally more pronounced among persons with co-occurring Axis I and/or Axis II disorders than those without these disorders. Treatment implications are discussed. JF - Addictive behaviors AU - DeMarce, Josephine M AU - Lash, Steven J AU - Stephens, Robert S AU - Grambow, Steven C AU - Burden, Jennifer L AD - Veterans Affairs Medical Center, Salem, Virginia 24153, United States. josephine.demarce@va.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1104 EP - 1112 VL - 33 IS - 9 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Substance-Related Disorders -- therapy KW - Residential Treatment KW - Substance Abuse Treatment Centers KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Substance-Related Disorders -- psychology KW - Male KW - Female KW - Continuity of Patient Care -- statistics & numerical data KW - Patient Compliance -- statistics & numerical data KW - Mental Disorders -- therapy KW - Patient Compliance -- psychology KW - Continuity of Patient Care -- standards KW - Mental Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69291371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Promoting+continuing+care+adherence+among+substance+abusers+with+co-occurring+psychiatric+disorders+following+residential+treatment.&rft.au=DeMarce%2C+Josephine+M%3BLash%2C+Steven+J%3BStephens%2C+Robert+S%3BGrambow%2C+Steven+C%3BBurden%2C+Jennifer+L&rft.aulast=DeMarce&rft.aufirst=Josephine&rft.date=2008-09-01&rft.volume=33&rft.issue=9&rft.spage=1104&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2008.02.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-16 N1 - Date created - 2008-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.addbeh.2008.02.008 ER - TY - JOUR T1 - Quantifying the decrement in utility from perceived side effects of combination antiretroviral therapies in patients with HIV. AN - 66714017; 18225989 AB - The decrement in utility attributable to side effects from combination antiretroviral therapy (CART) is unknown and likely to influence clinical decisions regarding CART initiation and cost-effectiveness. To quantify the decrement in utility attributable to side effects from CART. We estimated SF-6D utilities (quality-of-life weights on a scale from 0.29 [worst possible health] to 1.00 [perfect health]) from SF-12 scores among patients with HIV in the Veterans Aging Cohort Study by using a published and validated conversion algorithm. We then compared utilities among patients who: 1) did not have bothersome symptoms while taking CART; 2) had bothersome symptoms that they thought might be due to CART; and 3) had bothersome symptoms that they were confident were due to CART; we controlled for other characteristics known to influence quality of life and stratified analyses by CD4 count. Among 1864 patients with available data, symptoms perceived to be attributable to CART were associated with a mean (95% confidence interval) decrement in utility of 0.06 (0.05, 0.08) points in univariate analyses and 0.08 (0.06, 0.10) in multivariable analyses, clinically significant differences that are comparable to utility decrements reported for partial impotence or mild angina. Other significant predictors of changes in SF-6D utilities were hazardous alcohol consumption, recent drug use, cigarette smoking, homelessness, and African American race (R(2) = 0.12). Stratifying by CD4 count, symptoms attributable to CART side effects decreased utility by 0.03 to 0.08 points. Symptoms perceived to be related to CART are associated with a substantial decrement in utility. JF - Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research AU - Braithwaite, R Scott AU - Goulet, Joseph AU - Kudel, Ian AU - Tsevat, Joel AU - Justice, Amy C AD - Section of General Internal Medicine, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, CT 06516, USA. Ronald.Braithwaite@va.gov PY - 2008 SP - 975 EP - 979 VL - 11 IS - 5 KW - Anti-HIV Agents KW - 0 KW - Index Medicus KW - Humans KW - Aged KW - CD4 Lymphocyte Count KW - Multivariate Analysis KW - Veterans KW - Drug Therapy, Combination KW - Prospective Studies KW - Cost-Benefit Analysis KW - Adult KW - Confidence Intervals KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Male KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - Quality of Life KW - HIV Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66714017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Value+in+health+%3A+the+journal+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research&rft.atitle=Quantifying+the+decrement+in+utility+from+perceived+side+effects+of+combination+antiretroviral+therapies+in+patients+with+HIV.&rft.au=Braithwaite%2C+R+Scott%3BGoulet%2C+Joseph%3BKudel%2C+Ian%3BTsevat%2C+Joel%3BJustice%2C+Amy+C&rft.aulast=Braithwaite&rft.aufirst=R&rft.date=2008-09-01&rft.volume=11&rft.issue=5&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=Value+in+health+%3A+the+journal+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research&rft.issn=1524-4733&rft_id=info:doi/10.1111%2Fj.1524-4733.2007.00315.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-06-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 1987 Aug;126(2):310-8 [3300281] Med Care. 1996 Mar;34(3):220-33 [8628042] Med Care. 2000 Jun;38(6):583-637 [10843310] Value Health. 2006 Jul-Aug;9(4):262-71 [16903996] Med Care. 2004 Sep;42(9):851-9 [15319610] Clin Infect Dis. 2004 Aug 1;39(3):426-33 [15307012] J Clin Epidemiol. 2001 Dec;54 Suppl 1:S77-90 [11750213] J Pain Symptom Manage. 2001 Jan;21(1):41-51 [11223313] Qual Life Res. 2006 Aug;15(6):941-9 [16900275] J Stud Alcohol. 2005 Mar;66(2):305-8 [15957683] AIDS Care. 2005 Jul;17(5):579-88 [16036244] J Acquir Immune Defic Syndr. 2006 Aug 1;42(4):470-7 [16810114] Med Care. 2006 Aug;44(8 Suppl 2):S13-24 [16849964] Med Care. 2006 May;44(5):478-85 [16641667] Qual Life Res. 2006 Apr;15(3):503-14 [16547789] Int J STD AIDS. 2005 Sep;16(9):608-14 [16176627] Eur J Health Econ. 2005 Sep;6(3):253-60 [15968563] Qual Life Res. 2005 Aug;14(6):1523-32 [16110932] Qual Life Res. 2005 May;14(4):971-80 [16041894] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1524-4733.2007.00315.x ER - TY - JOUR T1 - COGNITIVE PROCESSING THERAPY FOR POSTTRAUMATIC STRESS DISORDER IN A RESIDENTIAL TREATMENT SETTING AN - 57301914; 200921150 AB - Cognitive processing therapy (CPT) is an exposure-based protocol designed to reduce posttraumatic stress disorder (PTSD) symptoms and challenge faulty beliefs and interpretations that prevent trauma survivors from coming to terms with their traumatic experiences. This article provides a brief summary of this treatment and the related literature and describes how the CPT protocol was modified to implement this treatment in this study's setting. Also provided is a discussion of various institutional and intrapatient barriers that existed before the introduction of CPT and how these difficulties were ultimately resolved. Patients' responses to treatment, as indicated by both qualitative and quantitative data, are also reviewed. A total of 18 patients participated and completed treatment with CPT (50% Caucasian, 22.2% African American, 16.7% biracial, 5.6% Native American, and 5.6% Hispanic). Overall, the women participating in the protocol benefited greatly, and 15 of the 18 women had a statistically significant reduction in scores measuring PTSD symptoms. The article concludes with recommendations to other programs and providers interested in providing CPT to similar treatment populations. [Copyright Educational Publishing Foundation.] JF - Psychotherapy: Theory/Research/Practice/Training AU - Zappert, Laurel N AU - Westrup, Darrah AD - Center for Neuroscience in Women's Health, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 361 EP - 376 PB - American Psychological Association, Washington DC VL - 45 IS - 3 SN - 0033-3204, 0033-3204 KW - PTSD cognitive processing women veterans exposure KW - Symptoms KW - Residential treatment KW - Posttraumatic stress disorder KW - Women KW - Cognitive processing KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57301914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychotherapy%3A+Theory%2FResearch%2FPractice%2FTraining&rft.atitle=COGNITIVE+PROCESSING+THERAPY+FOR+POSTTRAUMATIC+STRESS+DISORDER+IN+A+RESIDENTIAL+TREATMENT+SETTING&rft.au=Zappert%2C+Laurel+N%3BWestrup%2C+Darrah&rft.aulast=Zappert&rft.aufirst=Laurel&rft.date=2008-09-01&rft.volume=45&rft.issue=3&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Psychotherapy%3A+Theory%2FResearch%2FPractice%2FTraining&rft.issn=00333204&rft_id=info:doi/10.1037%2F0033-3204.45.3.361 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - PYSOAD N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Women; Symptoms; Cognitive processing; Residential treatment DO - http://dx.doi.org/10.1037/0033-3204.45.3.361 ER - TY - JOUR T1 - An Experimental Investigation of the Effect of Worry on Responses to a Discrimination Learning Task AN - 57295891; 200916766 AB - The current study examined the impact of both the tendency to worry (trait worry) and the process of worry (state worry) on subsequent behavioral responding in a schedule discrimination learning task. High and low trait worriers were randomly assigned to a state worry or relaxation incubation condition and completed a test of executive functioning and a dual contingency learning task that utilized neutral discriminative cues over the course of 2 contingency phases. Although state and trait worry did not impact executive functioning, the state worry condition was associated with diminished sensitivity to learning task contingencies over the course of the first contingency learning trials in comparison to the relaxation condition. This relationship was unique to the state worry condition above and beyond shared variance with subjective anxiety level. Results suggest that state worry may lead to a decrement in selective behavioral responding to neutral discriminative cues in the environment. The findings suggest that the process of worry may lead to less adaptive responding to neutral cues and interfere with adaptive behaviors, which may thereby contribute to and maintain anxiety. [Copyright Association for Behavioral and Cognitive Therapies. Published by Elsevier Ltd.] JF - Behavior Therapy AU - Salters-Pedneault, Kristalyn AU - Suvak, Michael AU - Roemer, Lizabeth AD - University of Massachusetts, Boston kristalyn.salters@va.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 251 EP - 261 PB - Elsevier Ltd, The Netherlands VL - 39 IS - 3 SN - 0005-7894, 0005-7894 KW - Learning KW - Anxiety KW - Worry KW - Relaxation KW - Discrimination KW - Contingencies KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57295891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Therapy&rft.atitle=An+Experimental+Investigation+of+the+Effect+of+Worry+on+Responses+to+a+Discrimination+Learning+Task&rft.au=Salters-Pedneault%2C+Kristalyn%3BSuvak%2C+Michael%3BRoemer%2C+Lizabeth&rft.aulast=Salters-Pedneault&rft.aufirst=Kristalyn&rft.date=2008-09-01&rft.volume=39&rft.issue=3&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Behavior+Therapy&rft.issn=00057894&rft_id=info:doi/10.1016%2Fj.beth.2008.01.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Learning; Worry; Relaxation; Anxiety; Contingencies; Discrimination DO - http://dx.doi.org/10.1016/j.beth.2008.01.001 ER - TY - JOUR T1 - Predictors of changes in alcohol-related self-efficacy over 16 years AN - 57268218; 200822165 AB - Self-efficacy is a robust predictor of short- and long-term remission after treatment. This study examined the predictors of self-efficacy in the year after treatment and 15 years later. A sample of 420 individuals with alcohol use disorders was assessed five times over the course of 16 years. Predictors of self-efficacy at 1 year included improvement from baseline to 1 year in heavy drinking, alcohol-related problems, depression, impulsivity, avoidance coping, social support from friends, and longer duration of participation in Alcoholics Anonymous (AA). Female gender, more education, less change in substance use problems, and impulsivity during the first year predicted improvement in self-efficacy over 16 years. Clinicians should focus on keeping patients engaged in AA, addressing depressive symptoms, improving patient's coping, and enhancing social support during the first year and reduce the risk of relapse by monitoring individuals whose alcohol problems and impulsivity improve unusually quickly. [Copyright 2008 Elsevier Inc.] JF - Journal of Substance Abuse Treatment AU - McKellar, John AU - Ilgen, Mark AU - Moos, Bernice S AU - Moos, Rudolf AD - Department of Veterans Affairs, Center for Health Care Evaluation, Palo Alto Health Care System, Menlo Park, CA 94025, USA john.mckellar@va.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 148 EP - 155 PB - Elsevier, New York NY VL - 35 IS - 2 SN - 0740-5472, 0740-5472 KW - Alcohol KW - Self-efficacy KW - Longitudinal KW - Selfefficacy KW - Social support KW - Predictors KW - Alcohol abuse KW - Remission KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57268218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Predictors+of+changes+in+alcohol-related+self-efficacy+over+16+years&rft.au=McKellar%2C+John%3BIlgen%2C+Mark%3BMoos%2C+Bernice+S%3BMoos%2C+Rudolf&rft.aulast=McKellar&rft.aufirst=John&rft.date=2008-09-01&rft.volume=35&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/10.1016%2Fj.jsat.2007.09.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Selfefficacy; Predictors; Alcohol abuse; Social support; Substance abuse; Remission DO - http://dx.doi.org/10.1016/j.jsat.2007.09.003 ER - TY - JOUR T1 - Are expressive suppression and cognitive reappraisal associated with stress-related symptoms? AN - 57264538; 200900649 AB - Emotion dysregulation is thought to be critical to the development of negative psychological outcomes. Gross (1998b) conceptualized the timing of regulation strategies as key to this relationship, with response-focused strategies, such as expressive suppression, as less effective and more detrimental compared to antecedent-focused ones, such as cognitive reappraisal. In the current study, we examined the relationship between reappraisal and expressive suppression and measures of psychopathology, particularly for stress-related reactions, in both undergraduate and trauma-exposed community samples of women. Generally, expressive suppression was associated with higher, and reappraisal with lower, self-reported stress-related symptoms. In particular, expressive suppression was associated with PTSD, anxiety, and depression symptoms in the trauma-exposed community sample, with rumination partially mediating this association. Finally, based on factor analysis, expressive suppression and cognitive reappraisal appear to be independent constructs. Overall, expressive suppression, much more so than cognitive reappraisal, may play an important role in the experience of stress-related symptoms. Further, given their independence, there are potentially relevant clinical implications, as interventions that shift one of these emotion regulation strategies may not lead to changes in the other. [Copyright 2008 Elsevier Ltd.] JF - Behaviour Research and Therapy AU - Moore, Sally A AU - Zoellner, Lori A AU - Mollenholt, Niklas AD - University of Washington, Department of Psychology, USA sally.moore2@va.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 993 EP - 1000 PB - Elsevier, Amsterdam The Netherlands VL - 46 IS - 9 SN - 0005-7967, 0005-7967 KW - Emotion regulation Expressive suppression Reappraisal Trauma Stress KW - Rumination KW - Emotional regulation KW - Stress KW - Suppression KW - Cognitive appraisal KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57264538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behaviour+Research+and+Therapy&rft.atitle=Are+expressive+suppression+and+cognitive+reappraisal+associated+with+stress-related+symptoms%3F&rft.au=Moore%2C+Sally+A%3BZoellner%2C+Lori+A%3BMollenholt%2C+Niklas&rft.aulast=Moore&rft.aufirst=Sally&rft.date=2008-09-01&rft.volume=46&rft.issue=9&rft.spage=993&rft.isbn=&rft.btitle=&rft.title=Behaviour+Research+and+Therapy&rft.issn=00057967&rft_id=info:doi/10.1016%2Fj.brat.2008.05.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-01-08 N1 - Last updated - 2016-09-27 N1 - CODEN - BRTHAA N1 - SubjectsTermNotLitGenreText - Suppression; Cognitive appraisal; Stress; Emotional regulation; Rumination DO - http://dx.doi.org/10.1016/j.brat.2008.05.001 ER - TY - JOUR T1 - Short communication: Gender differences in cocaine dependence AN - 57254751; 200822274 AB - Aims: This study examined gender differences among treatment-seeking cocaine-dependent outpatients (e.g., on demographics, psychopathology, and substance abuse). Participants: Participants were 2376 adults with cocaine dependence entering a multisite randomized controlled trial of psychosocial therapies. Findings: Women, compared to men, had less severe lifetime substance use problems but a higher pattern of psychiatric, medical, social/family, and employment problems; they also had more positive expectations and opinions about treatment. Conclusions: Women may be willing to engage in treatment but may have challenging economic and psychosocial concerns over and above their addiction. [Copyright 2008 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Najavits, Lisa M AU - Lester, Kristin M AD - VA Boston Healthcare System, Boston, MA 02130, USA lisa.najavits@va.gov Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 190 EP - 194 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 97 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Cocaine dependence KW - Psychopathology KW - Gender KW - Treatment KW - Socioeconomic factors KW - Psychosocial factors KW - Gender differences KW - Substance abuse KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57254751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Short+communication%3A+Gender+differences+in+cocaine+dependence&rft.au=Najavits%2C+Lisa+M%3BLester%2C+Kristin+M&rft.aulast=Najavits&rft.aufirst=Lisa&rft.date=2008-09-01&rft.volume=97&rft.issue=1-2&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2008.04.012 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Gender differences; Helpseeking; Substance abuse; Treatment; Psychosocial factors; Socioeconomic factors DO - http://dx.doi.org/10.1016/j.drugalcdep.2008.04.012 ER - TY - JOUR T1 - LMP-1 Retroviral Gene Therapy Influences Osteoblast Differentiation and Fracture Repair: A Preliminary Study AN - 19718044; 8598065 AB - LIM mineralization protein-1 (LMP-1) is a novel intracellular osteogenic factor associated with bone development that has been implicated in the bone morphogenetic protein (BMP) pathway. This preliminary study evaluated the possibility of LMP-1-based retroviral gene therapy to stimulate osteoblast differentiation in vitro and fracture repair in vivo. A Moloney leukemia virus (MLV)-based retroviral vector to express LMP-1 with a hemagglutinin (HA) tag was developed, and its effects were evaluated on MC3T3-E1 cell differentiation and in the rat femur fracture model. MC3T3-E1 osteoblasts transduced with the MLV-HA-LMP-1 vector demonstrated significantly increased osteoblast marker gene expression (P < 0.05) and mineral deposition compared to control transduced cells. Femoral midshaft fractures were produced in Fischer 344 rats by the three-point bending technique. The MLV-HA-LMP-1 or control vector was applied at the fracture site through percutaneous injections 1 day postfracture. Analysis of fracture healing of 10 MLV-HA-LMP-1-treated and 10 control MLV- beta -galactosidase ( beta -gal)-treated animals was completed at 3 weeks by X-ray, peripheral quantitative computed tomography, and histology. MLV-HA-LMP-1-treated animals had 63% more bone mineral content at the fracture site (P < 0.01), 34% greater total hard callus area (P < 0.05), and 45% less cartilage in the fracture callus (P < 0.05) compared to MLV- beta -gal-treated animals. There was no effect of LMP-1 treatment on the density of the hard callus. Immunohistochemistry revealed expression of the LMP-1 transgene in the fracture callus at 21 days postfracture. Immunohistochemistry also revealed that LMP-1 transgene expression did not result in an increase in BMP-4 expression in the fracture callus. Compared to MLV-BMP-4 gene therapy studies, MLV-HA-LMP-1 gene therapy improved bony union of the fracture gap to a greater extent and did not cause heterotopic bone formation. This suggests that LMP-1 may be a better potential candidate for gene therapy for fracture repair than BMP-4. These exciting, albeit preliminary, findings indicate that LMP-1-based gene therapy may potentially be a simple and effective means to enhance fracture repair that warrants further investigation. JF - Calcified Tissue International AU - Strohbach, Cassandra A AU - Rundle, Charles H AU - Wergedal, Jon E AU - Chen, Shin-Tai AU - Linkhart, Thomas A AU - Lau, K-HWilliam AU - Strong, Donna D AD - Jerry L. Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, CA, 92357, USA, Donna.Strong2@va.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 202 EP - 211 PB - Springer-Verlag, 175 Fifth Ave. New York NY 10010 USA, [mailto:orders@springer-ny.com], [URL:http://www.springer-ny.com/] VL - 83 IS - 3 SN - 0171-967X, 0171-967X KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Osteoblastogenesis KW - Gene therapy KW - Hemagglutinins KW - Cartilage KW - Fractures KW - Callus KW - Mineralization KW - Femur KW - Bone healing KW - Expression vectors KW - Osteoblasts KW - Bone morphogenetic proteins KW - osteogenic factor KW - Ossification (ectopic) KW - Ionizing radiation KW - Computed tomography KW - Bone mineral content KW - Immunohistochemistry KW - Bone morphogenetic protein 4 KW - W 30905:Medical Applications KW - T 2050:Genetics KW - G 07730:Development & Cell Cycle KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19718044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Calcified+Tissue+International&rft.atitle=LMP-1+Retroviral+Gene+Therapy+Influences+Osteoblast+Differentiation+and+Fracture+Repair%3A+A+Preliminary+Study&rft.au=Strohbach%2C+Cassandra+A%3BRundle%2C+Charles+H%3BWergedal%2C+Jon+E%3BChen%2C+Shin-Tai%3BLinkhart%2C+Thomas+A%3BLau%2C+K-HWilliam%3BStrong%2C+Donna+D&rft.aulast=Strohbach&rft.aufirst=Cassandra&rft.date=2008-09-01&rft.volume=83&rft.issue=3&rft.spage=202&rft.isbn=&rft.btitle=&rft.title=Calcified+Tissue+International&rft.issn=0171967X&rft_id=info:doi/10.1007%2Fs00223-008-9163-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Osteoblastogenesis; Gene therapy; Cartilage; Hemagglutinins; Fractures; Callus; Mineralization; Femur; Expression vectors; Bone healing; Osteoblasts; Bone morphogenetic proteins; osteogenic factor; Ossification (ectopic); Ionizing radiation; Computed tomography; Bone mineral content; Bone morphogenetic protein 4; Immunohistochemistry DO - http://dx.doi.org/10.1007/s00223-008-9163-0 ER - TY - JOUR T1 - Role of polyamine transport in Streptococcus pneumoniae response to physiological stress and murine septicemia AN - 19654243; 8419115 AB - Streptococcus pneumoniae has a potential ABC-type transporter (Pot) for extracellular polyamines. Polyamine transport protein D (PotD) is a membrane-associated, surface protein that putatively binds polyamines such as putrescine and spermidine. In this study we used quantitative PCR (qPCR) to analyze potD mRNA expression under physiologically relevant stress conditions in vitro, during in vivo infection, and in the presence of polyamines and choline. Expression of potD mRNA was elevated 2- and 4-fold when cells were grown at either 34 or 42 super(o)C, respectively, in a choline restricted environment. Expression increased by 5- and 11-fold in response to oxidative stress in either low or high choline environments, respectively. Putrescine led to an increase in potD mRNA transcription, while choline and spermidine resulted in decreased gene expression. Transcription of potD in pneumococci harvested from blood of systemically infected mice was 43-fold higher compared to in vitro transcription levels. Flow cytometry analysis using PotD antiserum confirmed increased PotD expression on the pneumococcal surface. These results indicate that polyamines and polyamine transport systems potentially play an important role in Streptococcus pneumoniae pathogenesis, and may be important for bacterial response to temperature shock, oxidative stress, choline limitation and in vivo growth. JF - Microbial Pathogenesis AU - Shah, P AU - Romero, D G AU - Swiatlo, E AD - University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216, USA, edwin.swiatlo@va.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 167 EP - 172 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 45 IS - 3 SN - 0882-4010, 0882-4010 KW - Microbiology Abstracts B: Bacteriology KW - Temperature effects KW - Choline KW - Septicemia KW - protein D KW - Transcription KW - Infection KW - Flow cytometry KW - Gene expression KW - Blood KW - Streptococcus pneumoniae KW - Putrescine KW - Shock KW - Spermidine KW - Oxidative stress KW - polyamines KW - Polymerase chain reaction KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19654243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Role+of+polyamine+transport+in+Streptococcus+pneumoniae+response+to+physiological+stress+and+murine+septicemia&rft.au=Shah%2C+P%3BRomero%2C+D+G%3BSwiatlo%2C+E&rft.aulast=Shah&rft.aufirst=P&rft.date=2008-09-01&rft.volume=45&rft.issue=3&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1016%2Fj.micpath.2008.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Choline; Septicemia; protein D; Transcription; Infection; Gene expression; Flow cytometry; Blood; Putrescine; Spermidine; Shock; polyamines; Oxidative stress; Polymerase chain reaction; Streptococcus pneumoniae DO - http://dx.doi.org/10.1016/j.micpath.2008.05.001 ER - TY - JOUR T1 - Coronary Sinus Diverticulum Complicating CRT Device Implantation AN - 19483533; 8532888 AB - Coronary sinus diverticula are rare findings usually associated with the presence of accessory pathways. We report the case of a 74-year-old man, who underwent cardiac resynchronization therapy (CRT) device implant. Coronary sinus diverticulum was an incidental finding while attempting to subselectively cannulate the coronary sinus for left ventricle lead implant. The case was able to be completed without complications. JF - Pacing and Clinical Electrophysiology AU - Thal, Sergio AU - Thai, Hoang AU - JUNEMAN, ELIZABETH AU - Goldman, Steven AD - Section of Cardiology, Department of Medicine, Southern Arizona VA Health Care System and Sarver Heart Center at the University of Arizona, Tucson, Arizona, sergio.thal@va.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1184 EP - 1185 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 31 IS - 9 SN - 0147-8389, 0147-8389 KW - Biotechnology and Bioengineering Abstracts KW - CRT KW - coronary sinus diverticulum KW - Heart KW - Ventricle KW - Sinus KW - Electrophysiology KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19483533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pacing+and+Clinical+Electrophysiology&rft.atitle=Coronary+Sinus+Diverticulum+Complicating+CRT+Device+Implantation&rft.au=Thal%2C+Sergio%3BThai%2C+Hoang%3BJUNEMAN%2C+ELIZABETH%3BGoldman%2C+Steven&rft.aulast=Thal&rft.aufirst=Sergio&rft.date=2008-09-01&rft.volume=31&rft.issue=9&rft.spage=1184&rft.isbn=&rft.btitle=&rft.title=Pacing+and+Clinical+Electrophysiology&rft.issn=01478389&rft_id=info:doi/10.1111%2Fj.1540-8159.2008.01160.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Ventricle; Sinus; Electrophysiology DO - http://dx.doi.org/10.1111/j.1540-8159.2008.01160.x ER - TY - JOUR T1 - Hemodialysis Central Venous Catheters as a Source of Inflammation and Its Implications AN - 19330245; 8648225 AB - The mortality rate for end-stage renal disease patients is six times higher than in the general population. Hemodialysis central venous catheter (CVC) utilization has increased by 50% between 1998 and 2004 and data from the United States Renal Data System suggest that 81% of the patients initiate hemodialysis through a CVC. There is evidence that the two observations are linked in both an obvious way (catheter-related sepsis) as well as in a less obvious manner-chronic inflammation. Inflammation is highly prevalent in chronic hemodialysis (CHD) patients and is consistently associated with poor outcomes. Some of the most important consequences of inflammation in CHD include, but are not limited to, cardiovascular disease, uremic protein-energy wasting, erythropoietin hyporesponsiveness, and increased hospitalization and death rates. Use of CVC has been long suspected to play a role in the inflammatory response in CHD patients. Recent studies have shown that the presence of CVCs is associated with higher levels of C-reactive protein (CRP), lower serum albumin values, and lower hemoglobin values. Furthermore, there are data showing that CRP levels decrease following CVC removal. Accordingly, avoidance of CVC represents an effective strategy to limit the inflammatory response in CHD patients and potentially prevent its devastating consequences. JF - Seminars in Dialysis AU - Hung, Adriana M AU - Alp Ikizler, T AD - Veterans Administration Tennessee Valley Healthcare System, Clinical Research Center of Excellence and Geriatric Research Education Clinical Center (GRECC), Nashville, Tennessee, adriana.hung@vanderbilt.edu Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 401 EP - 404 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 21 IS - 5 SN - 0894-0959, 0894-0959 KW - Microbiology Abstracts B: Bacteriology KW - Mortality KW - Data processing KW - Hemodialysis KW - Inflammation KW - Hemoglobin KW - Sepsis KW - Erythropoietin KW - Albumin KW - Kidney KW - Catheters KW - Cardiovascular diseases KW - End-stage renal disease KW - C-reactive protein KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19330245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Dialysis&rft.atitle=Hemodialysis+Central+Venous+Catheters+as+a+Source+of+Inflammation+and+Its+Implications&rft.au=Hung%2C+Adriana+M%3BAlp+Ikizler%2C+T&rft.aulast=Hung&rft.aufirst=Adriana&rft.date=2008-09-01&rft.volume=21&rft.issue=5&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Dialysis&rft.issn=08940959&rft_id=info:doi/10.1111%2Fj.1525-139X.2008.00444.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Hemodialysis; Inflammation; Hemoglobin; Sepsis; Erythropoietin; Albumin; Catheters; Kidney; Cardiovascular diseases; C-reactive protein; End-stage renal disease DO - http://dx.doi.org/10.1111/j.1525-139X.2008.00444.x ER - TY - JOUR T1 - Adverse effects of ropinirole-treated restless leg syndrome (RLS) during smoking cessation. AN - 69499847; 18763430 AB - The impact of nicotine on drug metabolism should be carefully considered, including its impact on ropinirole. The author presents a case in which a patient with RLS effectively treated with ropinirole (Requip) experienced profound side effects from ropinirole when she stopped smoking. JF - Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine AU - Juergens, Timothy M AD - Department of Veterans Affairs, University of Wisconsin School of Medicine and Public Health, Madison, WI. 53705, USA. Timothy.Juergens@med.va.gov Y1 - 2008/08/15/ PY - 2008 DA - 2008 Aug 15 SP - 371 EP - 372 VL - 4 IS - 4 SN - 1550-9389, 1550-9389 KW - Dopamine Agonists KW - 0 KW - Indoles KW - ropinirole KW - 030PYR8953 KW - Index Medicus KW - Smoking -- blood KW - Dose-Response Relationship, Drug KW - Humans KW - Middle Aged KW - Female KW - Indoles -- pharmacokinetics KW - Dopamine Agonists -- pharmacokinetics KW - Restless Legs Syndrome -- drug therapy KW - Smoking Cessation KW - Indoles -- adverse effects KW - Indoles -- administration & dosage KW - Dopamine Agonists -- adverse effects KW - Dopamine Agonists -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69499847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+sleep+medicine+%3A+JCSM+%3A+official+publication+of+the+American+Academy+of+Sleep+Medicine&rft.atitle=Adverse+effects+of+ropinirole-treated+restless+leg+syndrome+%28RLS%29+during+smoking+cessation.&rft.au=Juergens%2C+Timothy+M&rft.aulast=Juergens&rft.aufirst=Timothy&rft.date=2008-08-15&rft.volume=4&rft.issue=4&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+sleep+medicine+%3A+JCSM+%3A+official+publication+of+the+American+Academy+of+Sleep+Medicine&rft.issn=15509389&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-30 N1 - Date created - 2008-09-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Intern Med. 2005 Jun 13;165(11):1286-92 [15956009] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An Intention Manipulation to Change Lateralization of Word Production in Nonfluent Aphasia: Current Status AN - 85672056; 200902505 AB - A review of recent aphasia literature indicates that both the left and right hemispheres participate, under various circumstances, in recovery of language and in treatment response. In chronic aphasias with large lesions and poor recovery of function, the right hemisphere is more likely to demonstrate prominent activity than in cases with small lesions and good recoveries. Extraneous activity during language tasks for aphasia patients may occur in both the left and right hemispheres. Right hemisphere activity during language in aphasia patients is likely to occur in structures homologous to damaged left hemisphere structures. When the left hemisphere is so damaged as to preclude a good recovery, recruitment of right-hemisphere mechanisms in the service of rehabilitation may be desirable. Hence a treatment with an intention manipulation (complex left-hand movement) was developed for nonfluent aphasia to assist in relateralization of language production. A review of existing evidence indicates that the intention manipulation adds value to naming treatments and helps shift lateralization of language production to right frontal structures. However, wholesale transfer of language function to the right hemisphere does not occur, and residual language knowledge in the left hemisphere also seems vital for relearning of word production. Further research is needed to understand fully the contribution of the intention manipulation to treatment response. Adapted from the source document JF - Seminars in Speech and Language AU - Crosson, Bruce AD - Veterans Administration Rehabilitation Research & Development Brain Rehabilitation Research Center of Excellence, Malcom Randall VA Medical Center, Gainesville, FL Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 188 EP - 200 VL - 29 IS - 3 SN - 0734-0478, 0734-0478 KW - Functional Magnetic Resonance Imaging (fMRI) (26525) KW - Naming (56135) KW - Language Therapy (44400) KW - Intentionality (36680) KW - Aphasia (03400) KW - Recovery (Medical) (71880) KW - Lateralization (Neurolinguistics) (45385) KW - Speech Production (82780) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85672056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Speech+and+Language&rft.atitle=An+Intention+Manipulation+to+Change+Lateralization+of+Word+Production+in+Nonfluent+Aphasia%3A+Current+Status&rft.au=Crosson%2C+Bruce&rft.aulast=Crosson&rft.aufirst=Bruce&rft.date=2008-08-01&rft.volume=29&rft.issue=3&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Speech+and+Language&rft.issn=07340478&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2009-04-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Lateralization (Neurolinguistics) (45385); Recovery (Medical) (71880); Intentionality (36680); Aphasia (03400); Language Therapy (44400); Speech Production (82780); Naming (56135); Functional Magnetic Resonance Imaging (fMRI) (26525) ER - TY - JOUR T1 - Models of attention and dual-task performance as explanatory constructs in aphasia. AN - 85410023; pmid-18720315 AB - Aphasia has traditionally been viewed as a loss or impairment of language. However, evidence is presented suggesting that language mechanisms are fundamentally preserved and that aphasic language behaviors are instead due to impairments of cognitive processes supporting their construction. These processes may be understood as a linguistically specialized attentional system that is vulnerable to competition from other processing domains. We present two models of attention that focus on competition for central processing and discuss findings from dual-task studies of normal and aphasic performance. First, competing language and nonlanguage tasks appear to share limited-capacity, parallel processing resources. Second, aphasic individuals demonstrate slowed central processing that could be due to a reduction in processing capacity or ability to allocate that capacity. Third, the attention models discussed bear a coherent relationship to current models of language processing. Clinical implications of a cognitive processing account of aphasia are also considered. JF - Seminars in speech and language AU - Hula, William D AU - McNeil, Malcolm R AD - Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA. William.Hula@va.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 169 EP - 87; quiz C 3-4 VL - 29 IS - 3 SN - 0734-0478, 0734-0478 KW - Index Medicus KW - National Library of Medicine KW - *Aphasia: diagnosis KW - Aphasia: epidemiology KW - Aphasia: physiopathology KW - *Attention KW - Brain: physiopathology KW - Cognition Disorders: diagnosis KW - Cognition Disorders: epidemiology KW - Cognition Disorders: physiopathology KW - Humans KW - Reaction Time KW - *Refractory Period, Psychological: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85410023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+speech+and+language&rft.atitle=Models+of+attention+and+dual-task+performance+as+explanatory+constructs+in+aphasia.&rft.au=Hula%2C+William+D%3BMcNeil%2C+Malcolm+R&rft.aulast=Hula&rft.aufirst=William&rft.date=2008-08-01&rft.volume=29&rft.issue=3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Seminars+in+speech+and+language&rft.issn=07340478&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Application of the Transtheoretical Model of change: psychometric properties of leading measures in patients with co-occurring drug abuse and severe mental illness. AN - 71670979; 18485611 AB - People with severe mental illness (SMI) have high rates of substance use disorders. The Transtheoretical Model (TTM) is a framework for understanding behavior change. There are five leading measures associated with the TTM - University of Rhode Island Change Assessment, Processes of Change Scale, Decisional Balance Scale, Abstinence Self-Efficacy Scale, and Temptation to Use Drugs Scale. While these measures have been found to be reliable and valid in primary substance abusers, it is unknown if these measures are relevant in people with co-occurring SMI and substance use disorders (SUD). We evaluated the psychometric properties of these measures in a sample (n=240) of people with co-occurring disorders. Participants met DSM-IV criteria for schizophrenia/schizoaffective disorder or non-psychotic affective disorder, and current cocaine dependence or cocaine dependence in remission. All subscales showed good reliability and validity in the total sample. Analyses within diagnostic groups showed good reliability and validity in most groups, with some falling off in the affective disorders and remitted cocaine dependence groups. Overall, findings support the use of these measures in people with co-occurring disorders. JF - Addictive behaviors AU - Nidecker, Melissa AU - DiClemente, Carlo C AU - Bennett, Melanie E AU - Bellack, Alan S AD - VISN 5 Mental Illness, Research, Education, and Clinical Center, USA. Melissa.nidecka@va.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1021 EP - 1030 VL - 33 IS - 8 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Motivation KW - Rhode Island KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Schizophrenia -- rehabilitation KW - Psychometrics KW - Male KW - Female KW - Diagnostic and Statistical Manual of Mental Disorders KW - Models, Theoretical KW - Mood Disorders -- rehabilitation KW - Cocaine-Related Disorders -- psychology KW - Schizophrenic Psychology KW - Behavior Therapy -- methods KW - Cocaine-Related Disorders -- rehabilitation KW - Mood Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71670979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Application+of+the+Transtheoretical+Model+of+change%3A+psychometric+properties+of+leading+measures+in+patients+with+co-occurring+drug+abuse+and+severe+mental+illness.&rft.au=Nidecker%2C+Melissa%3BDiClemente%2C+Carlo+C%3BBennett%2C+Melanie+E%3BBellack%2C+Alan+S&rft.aulast=Nidecker&rft.aufirst=Melissa&rft.date=2008-08-01&rft.volume=33&rft.issue=8&rft.spage=1021&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2008.03.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-16 N1 - Date created - 2008-06-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Addict. 2004 Mar-Apr;13(2):103-19 [15204662] Community Ment Health J. 2003 Feb;39(1):3-15 [12650552] J Pers Soc Psychol. 1985 May;48(5):1279-89 [3998990] Schizophr Bull. 1987;13(2):261-76 [3616518] J Consult Clin Psychol. 1988 Aug;56(4):520-8 [3198809] Am J Psychiatry. 1991 Feb;148(2):224-30 [1987823] J Consult Clin Psychol. 1991 Apr;59(2):295-304 [2030191] Am J Psychiatry. 1991 Sep;148(9):1225-30 [1883002] Acta Psychiatr Scand. 1992 Jan;85(1):48-55 [1546548] J Nerv Ment Dis. 1992 Mar;180(3):197-201 [1588339] Br J Addict. 1992 May;87(5):743-54 [1591525] J Subst Abuse. 1990;2(2):217-35 [2136111] J Subst Abuse Treat. 1992;9(3):199-213 [1334156] J Nerv Ment Dis. 1993 Feb;181(2):71-9 [8426174] J Stud Alcohol. 1994 Mar;55(2):141-8 [8189734] Drug Alcohol Depend. 1994 Feb;34(3):201-9 [8033757] Schizophr Bull. 1995;21(2):313-21 [7631177] Drug Alcohol Depend. 1995 Jul;39(1):45-53 [7587974] Health Psychol. 1996 Nov;15(6):462-8 [8973927] J Stud Alcohol. 1997 Jan;58(1):7-29 [8979210] NIDA Res Monogr. 1997;172:86-109 [9154267] Acta Psychiatr Scand. 1997 Nov;96(5):329-33 [9395149] Psychiatr Q. 1998 Fall;69(3):169-91 [9682284] Alcohol Clin Exp Res. 1998 Sep;22(6):1300-11 [9756046] Am J Drug Alcohol Abuse. 1999 Feb;25(1):151-61 [10078983] Schizophr Bull. 1999;25(2):257-74 [10416730] Community Ment Health J. 1999 Aug;35(4):289-99 [10452697] Addict Behav. 1999 Jul-Aug;24(4):481-96 [10466844] Psychol Addict Behav. 2005 Mar;19(1):3-9 [15783272] Arch Gen Psychiatry. 2006 Apr;63(4):426-32 [16585472] Addict Behav. 2006 May;31(5):821-32 [15993545] AIDS Care. 2006 Oct;18(7):839-45 [16971296] Addict Behav. 2007 Sep;32(9):1798-813 [17287089] J Consult Clin Psychol. 2000 Oct;68(5):810-7 [11068967] Addict Behav. 2001 Jan-Feb;26(1):51-61 [11196292] J Stud Alcohol. 2001 Jan;62(1):79-88 [11271968] Psychiatr Serv. 2002 Apr;53(4):437-46 [11919357] Arch Gen Psychiatry. 2002 Apr;59(4):375-80 [11926938] Psychol Addict Behav. 2002 Sep;16(3):225-35 [12236457] J Nerv Ment Dis. 1980 Jan;168(1):26-33 [7351540] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.addbeh.2008.03.012 ER - TY - JOUR T1 - Risk of stroke, heart attack, and diabetes complications among veterans with spinal cord injury. AN - 69376279; 18674979 AB - To compare the rates of diabetes and macrovascular conditions in veterans with spinal cord injury (SCI) and to examine variations by patient-level demographic, socioeconomic, access, and health status factors. A retrospective analysis. Diabetes status was classified by merging with diabetes epidemiology cohort using a validated algorithm. Chi-square tests and logistic regressions used to compare rates in macro- and microvascular conditions in veterans with and without diabetes. Veteran Health Administration clinic users in fiscal year (FY) 1999 to FY 2001. SCI patients (N=8769) with diabetes (n=1333), in FY 2000, identified through the SCI registry. Not applicable. Macrovascular and microvascular conditions in the next year (February 2001). Derived from International Statistical Classification of Diseases, 9th Revision, Clinical Modification, codes in the patient treatment files. Overall, 15% of SCI veterans were identified with diabetes but this was an underestimate due to high mortality (8%). Among SCI veterans with diabetes, 49% had at least one macrovascular condition and 54% had microvascular conditions compared with 24% and 25% of those without diabetes (P<.001). Our study highlights the highly significant relationship between diabetes and macro- and microvascular conditions in veterans with SCI. Neurologic deficit combined with increased insulin resistance has a greater macrovascular impact on SCI veterans than on those who do not have diabetes. Increasing age and physical comorbidities compound the problem. JF - Archives of physical medicine and rehabilitation AU - Banerjea, Ranjana AU - Sambamoorthi, Usha AU - Weaver, Frances AU - Maney, Miriam AU - Pogach, Leonard M AU - Findley, Thomas AD - Department of Veteran Affairs, Health Services Research and Development Service Center for Health Care Knowledge and Management, East Orange, NJ 07018, USA. Ranjana.Banerjea@va.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1448 EP - 1453 VL - 89 IS - 8 KW - Abridged Index Medicus KW - Index Medicus KW - Causality KW - Diabetic Angiopathies -- epidemiology KW - Mental Disorders -- epidemiology KW - Humans KW - Retrospective Studies KW - Medical Staff, Hospital KW - Algorithms KW - Aged KW - Comorbidity KW - Life Style KW - Survival Rate KW - Cardiovascular Diseases -- epidemiology KW - Risk Factors KW - Cohort Studies KW - Confidence Intervals KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Male KW - Substance-Related Disorders -- epidemiology KW - Prevalence KW - Stroke -- epidemiology KW - Veterans -- statistics & numerical data KW - Diabetes Mellitus, Type 2 -- epidemiology KW - Spinal Cord Injuries -- epidemiology KW - Diabetes Complications -- epidemiology KW - Myocardial Infarction -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69376279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+physical+medicine+and+rehabilitation&rft.atitle=Risk+of+stroke%2C+heart+attack%2C+and+diabetes+complications+among+veterans+with+spinal+cord+injury.&rft.au=Banerjea%2C+Ranjana%3BSambamoorthi%2C+Usha%3BWeaver%2C+Frances%3BManey%2C+Miriam%3BPogach%2C+Leonard+M%3BFindley%2C+Thomas&rft.aulast=Banerjea&rft.aufirst=Ranjana&rft.date=2008-08-01&rft.volume=89&rft.issue=8&rft.spage=1448&rft.isbn=&rft.btitle=&rft.title=Archives+of+physical+medicine+and+rehabilitation&rft.issn=1532-821X&rft_id=info:doi/10.1016%2Fj.apmr.2007.12.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-06 N1 - Date created - 2008-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.apmr.2007.12.047 ER - TY - JOUR T1 - Autoantibodies and neurodegeneration in multiple sclerosis. AN - 69344608; 18521063 AB - Neurodegeneration develops in association with inflammation and demyelination in multiple sclerosis. Available data suggest that the progressive neuroaxonal loss begins in the earliest stages of the disease and underlies the accumulation of clinical disability. The loss of neurons and their processes is driven by a complex molecular mechanism involving cellular and humoral immune histotoxicity, demyelination, reduced neurotrophic support, metabolic impairment, and altered intracellular processes. Here we survey available data concerning the role of autoreactive immunoglobulins in neurotoxicity. A better understanding of molecular pathways leading to immune-mediated neurodegeneration may have key importance in the successful treatment of the disease. JF - Laboratory investigation; a journal of technical methods and pathology AU - Vyshkina, Tamara AU - Kalman, Bernadette AD - Veterans Administration Medical Center, Syracuse, NY 13210, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 796 EP - 807 VL - 88 IS - 8 KW - Autoantibodies KW - 0 KW - Index Medicus KW - Humans KW - Neurodegenerative Diseases -- immunology KW - Antibody Formation -- physiology KW - B-Lymphocytes -- physiology KW - Neurotoxicity Syndromes -- immunology KW - Autoantibodies -- physiology KW - Multiple Sclerosis -- immunology KW - Neurons -- immunology KW - Multiple Sclerosis -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69344608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Autoantibodies+and+neurodegeneration+in+multiple+sclerosis.&rft.au=Vyshkina%2C+Tamara%3BKalman%2C+Bernadette&rft.aulast=Vyshkina&rft.aufirst=Tamara&rft.date=2008-08-01&rft.volume=88&rft.issue=8&rft.spage=796&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=1530-0307&rft_id=info:doi/10.1038%2Flabinvest.2008.53 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-21 N1 - Date created - 2008-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/labinvest.2008.53 ER - TY - JOUR T1 - Sodium butyrate, an epigenetic interventional strategy, attenuates a stress-induced alteration of MK-801's pharmacologic action. AN - 69267465; 18164185 AB - Twenty-four hours after mice are exposed to a single session of forced swimming in cold water, the ability of MK-801 (dizocilpine), a noncompetitive NMDA receptor antagonist, to antagonize electrically precipitated seizures is reduced. Conceivably, this reduction in MK-801's antiseizure efficacy reflects a stress-induced alteration in NMDA receptor-mediated neurotransmission due to changes in gene expression 24 h after a single stress. Recently, epigenetic interventional strategies impacting expression of genes whose regulation is controlled by the acetylation status of histone proteins in the nucleosome, an octomeric complex of histone proteins and promoter regions of double-stranded DNA, have been tested in preclinical models of various neuropsychiatric disorders, including Huntington disease and major depression. These strategies have been studied extensively in cancer biology. In the current investigation, the severity of the stress-induced reduction of MK-801's ability to raise the threshold voltage for the elicitation of tonic hindlimb extension was reduced when sodium butyrate (1.5 g/kg, ip) was administered around the time of stress. Prior research showed that this dose of sodium butyrate reliably increased the acetylation status of H3 and H4 histone proteins in the hippocampus and cerebral cortex of mice. Thus, the attenuation of the stress-induced reduction of MK-801's antiseizure efficacy may be due to the increased acetylation of histone proteins in the nucleosomal core and promotion of gene expression. These data encourage development of epigenetic strategies to prevent some of the deleterious consequences of stress. JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology AU - Deutsch, Stephen I AU - Rosse, Richard B AU - Long, Katrice D AU - Gaskins, Brooke L AU - Burket, Jesssica A AU - Mastropaolo, John AD - Mental Health Service Line, Department of Veterans Affairs Medical Center, NW, Washington, DC 20422, United States. Stephen.Deutsch@med.va.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 565 EP - 568 VL - 18 IS - 8 SN - 0924-977X, 0924-977X KW - Butyrates KW - 0 KW - Neuroprotective Agents KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Electroshock -- adverse effects KW - Dose-Response Relationship, Drug KW - Mice KW - Male KW - Dizocilpine Maleate -- adverse effects KW - Epilepsy -- chemically induced KW - Stress, Psychological -- physiopathology KW - Neuroprotective Agents -- adverse effects KW - Epilepsy -- drug therapy KW - Butyrates -- therapeutic use KW - Stress, Psychological -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69267465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.atitle=Sodium+butyrate%2C+an+epigenetic+interventional+strategy%2C+attenuates+a+stress-induced+alteration+of+MK-801%27s+pharmacologic+action.&rft.au=Deutsch%2C+Stephen+I%3BRosse%2C+Richard+B%3BLong%2C+Katrice+D%3BGaskins%2C+Brooke+L%3BBurket%2C+Jesssica+A%3BMastropaolo%2C+John&rft.aulast=Deutsch&rft.aufirst=Stephen&rft.date=2008-08-01&rft.volume=18&rft.issue=8&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.issn=0924977X&rft_id=info:doi/10.1016%2Fj.euroneuro.2007.11.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-05 N1 - Date created - 2008-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.euroneuro.2007.11.004 ER - TY - JOUR T1 - Categorizing Pain in Patients Seen in a Veterans Health Administration Hospital: Pain as the Fifth Vital Sign AN - 57283497; 200917134 AB - Previous research has supported the concept of classifying pain intensity into distinct categories (of mild, moderate, and severe) based on the effects of pain on functioning. Such categories, however, have not been studied in samples of veterans. The current study sought to validate the concept of pain intensity classification in a sample of veterans with mixed types of chronic pain. There were 632 veterans referred to a pain program and asked to complete a packet of questionnaires that included a 0 to 10 measure of pain intensity and measures of pain-related interference, depressive symptomatology, and disability. The results indicated that the veterans' ratings of pain at its worst could be classified into the categories of mild, moderate, and severe, with cutpoints of a maximum rating of 3 for mild and 7 for moderate pain. The findings suggest that pain treatment studies of veterans with diverse types of chronic pain should include ratings of pain intensity at its worst that can be reliably classified as mild, moderate, or severe and related to other important outcomes such as daily function and mood. [Copyright Elsevier B.V.] JF - Psychological Services AU - Tan, Gabriel AU - Jensen, Mark P AU - Thornby, John I AU - Rintala, Diana H AU - Anderson, Karen O AD - ABPP, Chronic Pain Center, Anesthesiology (145 tan.gabriel@med.va.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 239 EP - 250 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 5 IS - 3 SN - 1541-1559, 1541-1559 KW - pain screening validating pain categories veterans' health pain interference fifth vital sign KW - Veterans KW - Classification KW - Chronic pain KW - Disability KW - Military hospitals KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57283497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Categorizing+Pain+in+Patients+Seen+in+a+Veterans+Health+Administration+Hospital%3A+Pain+as+the+Fifth+Vital+Sign&rft.au=Tan%2C+Gabriel%3BJensen%2C+Mark+P%3BThornby%2C+John+I%3BRintala%2C+Diana+H%3BAnderson%2C+Karen+O&rft.aulast=Tan&rft.aufirst=Gabriel&rft.date=2008-08-01&rft.volume=5&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2F1541-1559.5.3.239 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Chronic pain; Veterans; Hospitals; Military hospitals; Classification; Disability DO - http://dx.doi.org/10.1037/1541-1559.5.3.239 ER - TY - JOUR T1 - Building the Business Case for the Clinical Nurse Leader Role AN - 57281757; 200909121 AB - Abstract not available. JF - Nurse Leader AU - Harris, James L AU - Ott, Karen Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 25 EP - 28, 37 PB - Elsevier Ltd, The Netherlands VL - 6 IS - 4 SN - 1541-4612, 1541-4612 KW - Nursing KW - Leaders KW - Work roles KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nurse+Leader&rft.atitle=Building+the+Business+Case+for+the+Clinical+Nurse+Leader+Role&rft.au=Harris%2C+James+L%3BOtt%2C+Karen&rft.aulast=Harris&rft.aufirst=James&rft.date=2008-08-01&rft.volume=6&rft.issue=4&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Nurse+Leader&rft.issn=15414612&rft_id=info:doi/10.1016%2Fj.mnl.2008.06.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Leaders; Nursing; Work roles DO - http://dx.doi.org/10.1016/j.mnl.2008.06.002 ER - TY - JOUR T1 - Genetic and environmental contributions to nicotine, alcohol and cannabis dependence in male twins AN - 57279828; 200911065 AB - Aims To compute the common and specific genetic and environmental contributions to nicotine dependence (ND) alcohol dependence (AD) and cannabis dependence (CD). Design Twin model. Participants Data from 1874 monozygotic and 1498 dizygotic twin pair members of the Vietnam Era Twin Registry were obtained via telephone administration of a structured psychiatric interview in 1992. Measurements Data to derive life-time diagnoses of DSM-III-R ND, AD and CD were obtained via telephone administration of the Diagnostic Interview Schedule. Findings The best-fitting model allowed for additive genetic contributions and unique environmental influences that were common to all three phenotypes. Risks for ND and AD were also due to genetic and unique environmental influences specific to each drug. A specific shared environmental factor contributed to CD. Conclusions These results suggest that the life-time co-occurrence of ND, AD and CD is due to common and specific genetic factors as well as unique environmental influences, and vulnerability for CD is also due to shared environmental factors that do not contribute to ND and AD. The majority of genetic variance is shared across drugs and the majority of unique environmental influences are drug-specific in these middle-aged men. Because differences between models allowing for specific genetic versus shared environment were small, we are most confident in concluding that there are specific familial contributions -either additive genetic or shared environment -to CD. Submitted 4 October 2007; initial review completed 11 February 2008; final version accepted 11 March 2008. Adapted from the source document. JF - Addiction AU - Xian, Hong AU - Scherrer, Jeffrey F AU - Grant, Julia D AU - Eisen, Seth A AU - True, William R AU - Jacob, Theodore AU - Bucholz, Kathleen K AD - Research Service, St Louis Veterans Affairs Medical Center (VAMC), St Louis, MO, USA hong.xian@va.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1391 EP - 1398 PB - Blackwell Publishing, Oxford UK VL - 103 IS - 8 SN - 0965-2140, 0965-2140 KW - Genetic factors KW - Nicotine KW - Twin studies KW - Environmental aspects KW - Alcohol dependence KW - Cannabis KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57279828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Genetic+and+environmental+contributions+to+nicotine%2C+alcohol+and+cannabis+dependence+in+male+twins&rft.au=Xian%2C+Hong%3BScherrer%2C+Jeffrey+F%3BGrant%2C+Julia+D%3BEisen%2C+Seth+A%3BTrue%2C+William+R%3BJacob%2C+Theodore%3BBucholz%2C+Kathleen+K&rft.aulast=Xian&rft.aufirst=Hong&rft.date=2008-08-01&rft.volume=103&rft.issue=8&rft.spage=1391&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2008.02243.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Environmental aspects; Genetic factors; Nicotine; Alcohol dependence; Cannabis; Twin studies DO - http://dx.doi.org/10.1111/j.1360-0443.2008.02243.x ER - TY - JOUR T1 - Transformational Leadership at a National Perspective AN - 57277729; 200910962 AB - Abstract not available. JF - Nurse Leader AU - Weston, Marla J Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 41 EP - 45 PB - Elsevier Ltd, The Netherlands VL - 6 IS - 4 SN - 1541-4612, 1541-4612 KW - Transformational leadership KW - Nursing KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57277729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nurse+Leader&rft.atitle=Transformational+Leadership+at+a+National+Perspective&rft.au=Weston%2C+Marla+J&rft.aulast=Weston&rft.aufirst=Marla&rft.date=2008-08-01&rft.volume=6&rft.issue=4&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Nurse+Leader&rft.issn=15414612&rft_id=info:doi/10.1016%2Fj.mnl.2008.06.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nursing; Transformational leadership DO - http://dx.doi.org/10.1016/j.mnl.2008.06.001 ER - TY - JOUR T1 - The Association between Perceived Discrimination and Underutilization of Needed Medical and Mental Health Care in a Multi-Ethnic Community Sample AN - 57276916; 200821122 AB - This study examines the association between perceived discrimination and underutilization of needed medical and mental health care, in a representative, multi-ethnic community sample. Data were derived from a cross sectional survey of 10,098 White, U.S.- born Black, African-born Black, American Indian, Hispanic, and Southeast Asian adults in Hennepin County, Minnesota. Even after controlling for socio-demographic characteristics, health care access, and physical and mental health, perceived discrimination was associated with underutilization of medical care among Whites, U.S.-born Blacks, and American Indians and was associated with underutilization of mental health care among Whites, U.S.-born Blacks, Southeast Asians, and American Indians. Correlates of different types of discrimination (major, everyday, health care) on underutilization of care varied among ethnic groups. The higher prevalence of discrimination among racial and ethnic minorities may contribute to their underutilization of health care services. Future research is needed to understand the impacts of different types of discrimination on different groups. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Burgess, Diana J AU - Ding, Yingmei AU - Hargreaves, Margaret AU - van Ryn, Michelle AU - Phelan, Sean AD - Center for Chronic Disease Outcomes Research, Veterans Administration Medical Center, One Veterans Drive, Minneapolis, MN 55419 Tel: (612) 467-1591 diana.burgess@va.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 894 EP - 911 PB - John Hopkins University Press, Baltimore MD VL - 19 IS - 3 SN - 1049-2089, 1049-2089 KW - United States, racism, discrimination, health disparities, health services research KW - Perceptions KW - Mental health care KW - Health inequalities KW - Discrimination KW - Underuse KW - Minority groups KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57276916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=The+Association+between+Perceived+Discrimination+and+Underutilization+of+Needed+Medical+and+Mental+Health+Care+in+a+Multi-Ethnic+Community+Sample&rft.au=Burgess%2C+Diana+J%3BDing%2C+Yingmei%3BHargreaves%2C+Margaret%3Bvan+Ryn%2C+Michelle%3BPhelan%2C+Sean&rft.aulast=Burgess&rft.aufirst=Diana&rft.date=2008-08-01&rft.volume=19&rft.issue=3&rft.spage=894&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Perceptions; Health inequalities; Discrimination; Minority groups; Underuse; Mental health care ER - TY - JOUR T1 - Family-of-Origin Maltreatment, Posttraumatic Stress Disorder Symptoms, Social Information Processing Deficits, and Relationship Abuse Perpetration AN - 57276883; 200824165 AB - In this study, the authors examined the interrelations among family-of-origin maltreatment variables, posttraumatic stress disorder (PTSD) symptoms, social information processing deficits, and male-to-female psychological and physical intimate relationship abuse perpetration in adulthood among a community sample of 164 men and their partners. In bivariate analyses, higher family-of-origin childhood parental rejection was associated with the perpetration of psychological and physical abuse in adulthood, and childhood exposure to interparental violence was also associated with adult psychological abuse perpetration. Structural equation modeling analyses indicated that when childhood variables and other study variables were considered together, only childhood parental rejection was associated with the abuse perpetration outcomes, and these effects were indirect through PTSD symptoms and social information processing deficits. Results indicate a need for further investigation into the mechanisms accounting for the impact of early maltreatment on the development of abusive intimate relationship behavior. [Copyright 2008 American Psychological Association.] JF - Journal of Abnormal Psychology AU - Taft, Casey T AU - Schumm, Jeremiah A AU - Marshall, Amy D AU - Panuzio, Jillian AU - Holtzworth-Munroe, Amy AD - Veterans Affairs Boston Healthcare System, 150 Soutt Huntington Avenue, Boston, MA 02130 casey.taft@va.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 637 EP - 646 PB - American Psychological Association, Washington DC VL - 117 IS - 3 SN - 0021-843X, 0021-843X KW - child maltreatment, posttraumatic stress disorder, information processing, domestic abuse, relationship aggression KW - Posttraumatic stress disorder KW - Social information processing KW - Child maltreatment KW - Parental rejection KW - Domestic violence KW - Aggression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57276883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Psychology&rft.atitle=Family-of-Origin+Maltreatment%2C+Posttraumatic+Stress+Disorder+Symptoms%2C+Social+Information+Processing+Deficits%2C+and+Relationship+Abuse+Perpetration&rft.au=Taft%2C+Casey+T%3BSchumm%2C+Jeremiah+A%3BMarshall%2C+Amy+D%3BPanuzio%2C+Jillian%3BHoltzworth-Munroe%2C+Amy&rft.aulast=Taft&rft.aufirst=Casey&rft.date=2008-08-01&rft.volume=117&rft.issue=3&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Psychology&rft.issn=0021843X&rft_id=info:doi/10.1037%2F0021-843X.117.3.637 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-12-09 N1 - Last updated - 2016-09-27 N1 - CODEN - JABCAA N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Domestic violence; Child maltreatment; Social information processing; Aggression; Parental rejection DO - http://dx.doi.org/10.1037/0021-843X.117.3.637 ER - TY - JOUR T1 - An Examination of Family Adjustment Among Operation Desert Storm Veterans AN - 57252930; 200822805 AB - This study examined interrelationships among combat exposure, symptoms of posttraumatic stress disorder (PTSD), and family adjustment in a sample of male and female Operation Desert Storm veterans (N = 1,512). In structural equation models for both male and female veterans, higher combat exposure was associated with higher PTSD symptoms, which in turn were associated with poorer family adjustment, although these indirect effects did not reach statistical significance. The model for female veterans evidenced a significant direct negative association between combat exposure and family adjustment when it statistically accounted for PTSD symptoms. When the relative impacts of separate PTSD symptom groupings were examined, those reflecting withdrawal/numbing symptoms and arousal/lack of control symptoms significantly and indirectly accounted for the negative effects of combat exposure on family adjustment. Study findings indicate a number of possible pathways through which war-zone deployments negatively impact military families and suggest several avenues for future research. [Copyright 2008 American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Taft, Casey T AU - Schumm, Jeremiah A AU - Panuzio, Jillian AU - Proctor, Susan P AD - Veterans Affairs Boston Healthcare System (116B-2), 150 South Huntington Avenue, Boston, MA 02130 casey.taft@va.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 648 EP - 656 PB - American Psychological Association, Washington DC VL - 76 IS - 4 SN - 0022-006X, 0022-006X KW - combat, posttraumatic stress disorder, family, veterans KW - Indirect effects KW - Veterans KW - Wars KW - Posttraumatic stress disorder KW - Exposure KW - Adjustment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57252930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=An+Examination+of+Family+Adjustment+Among+Operation+Desert+Storm+Veterans&rft.au=Taft%2C+Casey+T%3BSchumm%2C+Jeremiah+A%3BPanuzio%2C+Jillian%3BProctor%2C+Susan+P&rft.aulast=Taft&rft.aufirst=Casey&rft.date=2008-08-01&rft.volume=76&rft.issue=4&rft.spage=648&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2Fa0012576 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Adjustment; Veterans; Posttraumatic stress disorder; Exposure; Wars; Indirect effects DO - http://dx.doi.org/10.1037/a0012576 ER - TY - JOUR T1 - Rat Pneumonia and Soft-Tissue Infection Models for the Study of Acinetobacter baumannii Biology AN - 21491215; 12495568 AB - Acinetobacter baumannii is a bacterial pathogen of increasing medical importance. Little is known about its mechanisms of pathogenesis, and safe reliable agents with predictable activity against A. baumannii are presently nonexistent. The availability of relevant animal infection models will facilitate the study of Acinetobacter biology. In this report we tested the hypothesis that the rat pneumonia and soft-tissue infection models that our laboratory had previously used for studies of extraintestinal pathogenic Escherichia coli were clinically relevant for A. baumannii. Advantages of these models over previously described models were that the animals were not rendered neutropenic and they did not receive porcine mucin with bacterial challenge. Using the A. baumannii model pathogen 307-0294 as the challenge pathogen, the pneumonia model demonstrated all of the features of infection that are critical for a clinically relevant model: namely, bacterial growth/clearance, an ensuing host inflammatory response, acute lung injury, and, following progressive bacterial proliferation, death due to respiratory failure. We were also able to demonstrate growth of 307-0294 in the soft-tissue infection model. Next we tested the hypothesis that the soft-tissue infection model could be used to discriminate between the inherent differences in virulence of various A. baumannii clinical isolates. The ability of A. baumannii to grow and/or be cleared in this model was dependent on the challenge strain. We also hypothesized that complement is an important host factor in protecting against A. baumannii infection in vivo. In support of this hypothesis was the observation that the serum sensitivity of various A. baumannii clinical isolates in vitro roughly paralleled their growth/clearance in the soft-tissue infection model in vivo. Lastly we hypothesized that the soft-tissue infection model would serve as an efficient screening mechanism for identifying gene essentiality for drug discovery. Random mutants of 307-0294 were initially screened for lack of growth in human ascites in vitro. Selected mutants were subsequently used for challenge in the soft-tissue infection model to determine if the disrupted gene was essential for growth in vivo. Using this approach, we have been able to successfully identify a number of genes essential for the growth of 307-0294 in vivo. In summary, these models are clinically relevant and can be used to study the innate virulence of various Acinetobacter clinical isolates and to assess potential virulence factors, vaccine candidates, and drug targets in vivo and can be used for pharmacokinetic and chemotherapeutic investigations. JF - Infection and Immunity AU - Russo, Thomas A AU - Beanan, Janet M AU - Olson, Ruth AU - MacDonald, Ulrike AU - Luke, Nicole R AU - Gill, Steven R AU - Campagnari, Anthony A AD - Veterans Administration Western New York Healthcare System, trusso@acsu.buffalo.edu Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 3577 EP - 3586 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 8 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Clinical isolates KW - virulence factors KW - Injuries KW - Animal models KW - Medical importance KW - Drug development KW - Pathogens KW - Infection KW - Pharmacokinetics KW - Models KW - Inflammation KW - Neutropenia KW - Drug discovery KW - Acinetobacter KW - Acinetobacter baumannii KW - Lung KW - Ascites KW - Escherichia coli KW - mucin KW - Vaccines KW - Drugs KW - Pneumonia KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21491215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Rat+Pneumonia+and+Soft-Tissue+Infection+Models+for+the+Study+of+Acinetobacter+baumannii+Biology&rft.au=Russo%2C+Thomas+A%3BBeanan%2C+Janet+M%3BOlson%2C+Ruth%3BMacDonald%2C+Ulrike%3BLuke%2C+Nicole+R%3BGill%2C+Steven+R%3BCampagnari%2C+Anthony+A&rft.aulast=Russo&rft.aufirst=Thomas&rft.date=2008-08-01&rft.volume=76&rft.issue=8&rft.spage=3577&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00269-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Injuries; virulence factors; Animal models; Medical importance; Drug development; Pathogens; Infection; Pharmacokinetics; Inflammation; Models; Drug discovery; Neutropenia; Ascites; Lung; mucin; Vaccines; Drugs; Pneumonia; Acinetobacter baumannii; Acinetobacter; Escherichia coli DO - http://dx.doi.org/10.1128/IAI.00269-08 ER - TY - JOUR T1 - Community Socioeconomic Status is Associated With Circulating Interleukin-6 and C-Reactive Protein AN - 21224133; 11273659 AB - Objective: To examine the association of both individual and community socioeconomic status (SES) with inflammatory mediators relevant to cardiovascular pathophysiology, i.e., interleukin (IL)-6 and C-reactive protein (CRP), in a midlife community sample. Growing evidence suggests that socioeconomic attributes of both individuals and communities confer risk for cardiovascular morbidity and mortality. Methods: Subjects were 851 men and women, 30 to 54 years of age (Caucasian = 77%, African-American = 23%). Individual SES was indexed by a composite of educational attainment and family income, and community SES was indexed by corresponding indicators derived from US Census data for participants' census tracts of residence. Plasma concentrations of IL-6 and CRP were determined from blood samples. Results: Regression analyses adjusting for age, sex, and race showed individual SES to be associated inversely with IL-6 (B = -0.126, p .10). After adjustment for lifestyle factors, however, individual SES was no longer associated with IL-6. Conclusions: Independent of personal income or educational attainment, midlife adults living in less advantaged neighborhoods exhibit higher levels of circulating proinflammatory markers than residents of more affluent areas. This association may help explain the increased risk of atherosclerotic cardiovascular morbidity and mortality conferred by low community-level SES. JF - Psychosomatic Medicine AU - Petersen, K L AU - Marsland, AL AU - Flory, J AU - Votruba-Drzal, E AU - Muldoon, M F AU - Manuck, S B AD - Minneapolis Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA, karen.petersen2@va.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 646 EP - 652 VL - 70 IS - 6 SN - 0033-3174, 0033-3174 KW - Risk Abstracts; CSA Neurosciences Abstracts; Immunology Abstracts KW - Interleukin 6 KW - Age KW - Socioeconomics KW - Arteriosclerosis KW - affluence KW - Morbidity KW - Smoking KW - body mass KW - income KW - Risk factors KW - Regression analysis KW - Ethnic groups KW - Races KW - Ethanol KW - Sex KW - census KW - Alcohol KW - Mortality KW - Data processing KW - Inflammation KW - Physical training KW - Socio-economic aspects KW - Sleep KW - Africa KW - Proteins KW - Census KW - Cardiovascular diseases KW - Body mass index KW - C-reactive protein KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23060:Medical and environmental health KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21224133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+Medicine&rft.atitle=Community+Socioeconomic+Status+is+Associated+With+Circulating+Interleukin-6+and+C-Reactive+Protein&rft.au=Petersen%2C+K+L%3BMarsland%2C+AL%3BFlory%2C+J%3BVotruba-Drzal%2C+E%3BMuldoon%2C+M+F%3BManuck%2C+S+B&rft.aulast=Petersen&rft.aufirst=K&rft.date=2008-08-01&rft.volume=70&rft.issue=6&rft.spage=646&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+Medicine&rft.issn=00333174&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Mortality; Age; Data processing; Arteriosclerosis; Morbidity; Physical training; Inflammation; Smoking; Socio-economic aspects; Risk factors; Sleep; Regression analysis; Census; Cardiovascular diseases; Body mass index; Races; Sex; C-reactive protein; Ethanol; census; Alcohol; body mass; income; Proteins; Socioeconomics; affluence; Ethnic groups; Africa ER - TY - JOUR T1 - Isolation and Transcriptional Profiling of Purified Hepatic Cells Derived from Human Embryonic Stem Cells AN - 20902257; 8407931 AB - The differentiation of human embryonic stem cells (hESCs) into functional hepatocytes provides a powerful in vitro model system for studying the molecular mechanisms governing liver development. Furthermore, a well-characterized renewable supply of hepatocytes differentiated from hESCs could be used for in vitro assays of drug metabolism and toxicology, screening of potential antiviral agents, and cell-based therapies to treat liver disease. In this study, we describe a protocol for the differentiation of hESCs toward hepatic cells with complex cellular morphologies. Putative hepatic cells were identified and isolated using a lentiviral vector, containing the alpha -fetoprotein promoter driving enhanced green fluorescent protein expression (AFP:eGFP). Whole-genome transcriptional profiling was performed on triplicate samples of AFP:eGFP+ and AFP:eGFP- cell populations using the recently released Affymetrix Exon Array ST 1.0 (Santa Clara, CA, http://www.affymetrix.com). Statistical analysis of the transcriptional profiles demonstrated that the AFP:eGFP+ population is highly enriched for genes characteristic of hepatic cells. These data provide a unique insight into the complex process of hepatocyte differentiation, point to signaling pathways that may be manipulated to more efficiently direct the differentiation of hESCs toward mature hepatocytes, and identify molecular markers that may be used for further dissection of hepatic cell differentiation from hESCs. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Chiao, Eric AU - Elazar, Menashe AU - Xing, Yi AU - Xiong, Anming AU - Kmet, Muriel AU - Millan, Maria T AU - Glenn, Jeffrey S AU - Wong, Wing H AU - Baker, Julie AD - Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, California, USA. Department of Genetics, Stanford University School of Medicine, Palo Alto, California, USA. Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California, USA. Departments of Internal Medicine, Biomedical Engineering, University of Iowa, Iowa City, Iowa, USA. Department of Surgery, Liver Transplantation Division, Stanford University School of Medicine, Veterans Administration Medical Center, Palo Alto, California, USA. Department of Statistics and Health Research and Policy, Stanford University, Palo Alto, California, USA Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 2032 EP - 2041 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 26 IS - 8 SN - 1066-5099, 1066-5099 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Data processing KW - Liver diseases KW - Exons KW - Hepatocytes KW - Drug metabolism KW - alpha -fetoprotein KW - Statistical analysis KW - Green fluorescent protein KW - Transcription KW - Expression vectors KW - Promoters KW - Differentiation KW - Stem cells KW - Embryo cells KW - Antiviral agents KW - Signal transduction KW - V 22420:Plant Diseases KW - N 14830:RNA KW - W 30915:Pharmaceuticals & Vaccines KW - W 30965:Miscellaneous, Reviews KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20902257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Isolation+and+Transcriptional+Profiling+of+Purified+Hepatic+Cells+Derived+from+Human+Embryonic+Stem+Cells&rft.au=Chiao%2C+Eric%3BElazar%2C+Menashe%3BXing%2C+Yi%3BXiong%2C+Anming%3BKmet%2C+Muriel%3BMillan%2C+Maria+T%3BGlenn%2C+Jeffrey+S%3BWong%2C+Wing+H%3BBaker%2C+Julie&rft.aulast=Chiao&rft.aufirst=Eric&rft.date=2008-08-01&rft.volume=26&rft.issue=8&rft.spage=2032&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Liver diseases; Data processing; Hepatocytes; Exons; Drug metabolism; Green fluorescent protein; Statistical analysis; alpha -fetoprotein; Transcription; Expression vectors; Differentiation; Promoters; Stem cells; Antiviral agents; Embryo cells; Signal transduction ER - TY - JOUR T1 - Eastern equine encephalitis leading to multi-organ failure and sepsis AN - 20858178; 8352851 JF - Journal of Clinical Virology AU - Reddy, A J AU - Woods, C W AU - Welty-Wolf, KE AD - Allergy and Critical Care Medicine, Department of Medicine, Durham Veterans Administration and Duke University Medical Centers, Durham, NC 27710, United States, reddya3@ccf.org Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 418 EP - 421 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 42 IS - 4 SN - 1386-6532, 1386-6532 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Sepsis KW - Eastern equine encephalitis KW - V 22410:Animal Diseases KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20858178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Virology&rft.atitle=Eastern+equine+encephalitis+leading+to+multi-organ+failure+and+sepsis&rft.au=Reddy%2C+A+J%3BWoods%2C+C+W%3BWelty-Wolf%2C+KE&rft.aulast=Reddy&rft.aufirst=A&rft.date=2008-08-01&rft.volume=42&rft.issue=4&rft.spage=418&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Virology&rft.issn=13866532&rft_id=info:doi/10.1016%2Fj.jcv.2008.03.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Sepsis; Eastern equine encephalitis DO - http://dx.doi.org/10.1016/j.jcv.2008.03.008 ER - TY - JOUR T1 - Biomechanical Assessment of Type II Superior Labral Anterior-Posterior (SLAP) Lesions Associated With Anterior Shoulder Capsular Laxity as Seen in Throwers. A Cadaveric Study AN - 20082726; 10095308 AB - Background: Type II superior labral anterior-posterior lesions in throwers are often associated with anterior shoulder capsular laxity.Hypothesis: Shoulder instability in patients with type II superior labral anterior-posterior lesions may result from the associated shoulder capsular laxity rather than the superior labral anterior-posterior lesion alone.Study Design: Controlled laboratory study.Methods: Six cadaveric shoulders were externally rotated to 20% beyond the maximum humeral external rotation at 60 degree of glenohumeral abduction, which simulated 90 degree of shoulder abduction, to detach the superior labrum and elongate the anterior shoulder capsular ligaments. The detached labrum was then repaired to isolate the effect of the detached superior labrum and that of the capsular laxity. Rotational range of motion was measured at 60 degree of glenohumeral abduction. Anterior-posterior glenohumeral translation was measured at 30 degree and 60 degree of glenohumeral abduction. Superior-inferior glenohumeral translation was measured at 0 degree and 60 degree of glenohumeral abduction.Results: The experimentally created type II superior labral anterior-posterior lesion and capsular laxity significantly increased anterior translation at 30 degree (mean difference, 1.0 plus or minus 0.8 mm; P < .05) and 60 degree (mean difference, 2.2 plus or minus 2.0 mm; P < .05) of glenohumeral abduction. Subsequent superior labral anterior-posterior repair restored the anterior translation but only at 30 degree of glenohumeral abduction (mean difference, 0.9 plus or minus 0.6 mm; P < .05).Conclusion: Because of the anterior capsular laxity associated with type II superior labral anterior-posterior lesions, superior labral anterior-posterior repair of the peeled-back superior labrum may not restore anterior glenohumeral translation at 90 degree of shoulder abduction.Clinical Relevance: Anterior shoulder capsular laxity associated with type II superior labral anterior-posterior lesions may cause anterior shoulder instability at 90 degree of shoulder abduction in throwers even after superior labral anterior-posterior lesion repair. JF - American Journal of Sports Medicine AU - Mihata, Teruhisa AU - McGarry, Michelle H AU - Tibone, James E AU - Fitzpatrick, Michael J AU - Kinoshita, Mitsuo AU - Lee, Thay Q AD - Orthopaedic Biomechanics Laboratory, VA Long Beach Healthcare System, Long Beach, California, University of California, Irvine, Irvine, California, Osaka Medical College, Takatsuki, Osaka, Japan, tqlee@med.va.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 1604 EP - 1610 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 36 IS - 8 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Evaluation KW - Measurement KW - Ligaments KW - Flexibility KW - Shoulders KW - Patients KW - Sports medicine KW - Biomechanics KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20082726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Biomechanical+Assessment+of+Type+II+Superior+Labral+Anterior-Posterior+%28SLAP%29+Lesions+Associated+With+Anterior+Shoulder+Capsular+Laxity+as+Seen+in+Throwers.+A+Cadaveric+Study&rft.au=Mihata%2C+Teruhisa%3BMcGarry%2C+Michelle+H%3BTibone%2C+James+E%3BFitzpatrick%2C+Michael+J%3BKinoshita%2C+Mitsuo%3BLee%2C+Thay+Q&rft.aulast=Mihata&rft.aufirst=Teruhisa&rft.date=2008-08-01&rft.volume=36&rft.issue=8&rft.spage=1604&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F0363546508315198 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Evaluation; Measurement; Ligaments; Flexibility; Patients; Shoulders; Sports medicine; Biomechanics DO - http://dx.doi.org/10.1177/0363546508315198 ER - TY - JOUR T1 - Physical Activity and Cardiovascular Disease Prevention: Current Recommendations AN - 20050968; 10102823 AB - Epidemiologic studies support an inverse and robust relationship between physical activity (PA) and mortality risk, even after adjusting for potential confounding factors. The authors have reported 13% lower mortality risk for every 1-MET (metabolic equivalent) increase in exercise capacity. For those with an exercise capacity >7 METs, the mortality risk was approximately 50% to 70% lower when compared with those achieving <5 METs. The risk reduction is, at least in part, attributed to the favorable effect of PA on the cardiovascular risk factors. Increased PA lowers blood pressure in hypertensive individuals, increases high-density lipoprotein cholesterol in a dose-response fashion, and reduces the incidence of diabetes. The health benefits of PA can be realized by engaging in moderate-intensity physical activity (brisk walk) for at least 30 minutes per day, 5 days per week or vigorous activity (jogging) for 20 or more minutes, 3 days per week. Combinations of the 2 types of activity can also be performed. JF - Angiology AU - Kokkinos, Peter AD - Veterans Affairs Medical Center/Cardiology and Georgetown University School of Medicine, Washington, DC, peter.kokkinos@med.va.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 26S EP - 29S PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 59 IS - 2 SN - 0003-3197, 0003-3197 KW - Physical Education Index KW - cardiovascular risk KW - exercise KW - Death KW - Preventive health KW - Lipids KW - Running KW - Cardiorespiratory KW - Exercise KW - Baseball KW - Exercise (effects) KW - Professional sports KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20050968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Angiology&rft.atitle=Physical+Activity+and+Cardiovascular+Disease+Prevention%3A+Current+Recommendations&rft.au=Kokkinos%2C+Peter&rft.aulast=Kokkinos&rft.aufirst=Peter&rft.date=2008-08-01&rft.volume=59&rft.issue=2&rft.spage=26S&rft.isbn=&rft.btitle=&rft.title=Angiology&rft.issn=00033197&rft_id=info:doi/10.1177%2F0003319708318582 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Death; Preventive health; Running; Lipids; Cardiorespiratory; Exercise (effects); Baseball; Exercise; Professional sports DO - http://dx.doi.org/10.1177/0003319708318582 ER - TY - CPAPER T1 - Bone Density Around Endosseous Implants in Patients Taking Alendronate (Fosamax@@uAAAARG@) T2 - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AN - 40981581; 4875012 JF - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AU - Griffiths, G Y1 - 2008/07/02/ PY - 2008 DA - 2008 Jul 02 KW - Bone density KW - Bisphosphonates KW - Alendronic acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40981581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.atitle=Bone+Density+Around+Endosseous+Implants+in+Patients+Taking+Alendronate+%28Fosamax%40%40uAAAARG%40%29&rft.au=Griffiths%2C+G&rft.aulast=Griffiths&rft.aufirst=G&rft.date=2008-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2008Toronto/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Expression of a functional single-chain antibody via Corynebacterium pseudodiphtheriticum AN - 872128234; 14031935 AB - Antibody-based therapeutics are effective against conditions ranging from acute infections to malignancy. They may prove crucial in combating bioterrorism and responding to drug-resistant and emerging pathogens. At present the cost of producing therapeutic monoclonal antibodies is between 1,000 to 6,000 per gram. The need to administer antibodies parenterally at frequent intervals further drives the cost of this treatment. Here we present an antibody delivery system, termed paratransgenesis, with the potential to overcome these limitations. The paratransgenic approach involves genetically transforming a commensal or symbiont bacterium to express foreign molecules that target pathogens. We describe transformation of Corynebacterium pseudodiptheriticum, a commensal bacterium found in the human respiratory tract, to express a murine single-chain antibody binding progesterone. The antibody was functional and bound specifically to progesterone in a concentration-dependent manner. This marker antibody system is the precursor to development of expression systems producing recombinant humanized single-chain antibodies. Studies are in progress evaluating fitness, transgene stablility, and pathogenecity of the genetically engineered C. pseudodiptheriticum. We anticipate developing a repertoire of expressed molecules targeting infectious agents and surface epitopes of pulmonary mass lesions. If expression systems for anti-pathogen molecules in C. pseudodiptheriticum and other respiratory commensal bacteria can be optimized, these bacteria have the potential for a range of therapeutic and prophylactic applications. JF - European Journal of Clinical Microbiology & Infectious Diseases AU - Sundaram, R K AU - Hurwitz, I AU - Matthews, S AU - Hoy, E AU - Kurapati, S AU - Crawford, C AU - Sundaram, P AU - Durvasula, R V AD - Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA, ravi.durvasula@med.va.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 617 EP - 622 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 27 IS - 7 SN - 0934-9723, 0934-9723 KW - Microbiology Abstracts B: Bacteriology KW - Transformation KW - Fitness KW - Symbionts KW - Progesterone KW - Monoclonal antibodies KW - bioterrorism KW - Drug resistance KW - Transgenes KW - Commensals KW - Pathogens KW - Infection KW - Corynebacterium KW - Malignancy KW - Lung KW - Genetic engineering KW - Epitopes KW - Respiratory tract KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872128234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.atitle=Expression+of+a+functional+single-chain+antibody+via+Corynebacterium+pseudodiphtheriticum&rft.au=Sundaram%2C+R+K%3BHurwitz%2C+I%3BMatthews%2C+S%3BHoy%2C+E%3BKurapati%2C+S%3BCrawford%2C+C%3BSundaram%2C+P%3BDurvasula%2C+R+V&rft.aulast=Sundaram&rft.aufirst=R&rft.date=2008-07-01&rft.volume=27&rft.issue=7&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.issn=09349723&rft_id=info:doi/10.1007%2Fs10096-008-0483-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Fitness; Transformation; Symbionts; Progesterone; bioterrorism; Monoclonal antibodies; Drug resistance; Transgenes; Commensals; Pathogens; Infection; Malignancy; Lung; Genetic engineering; Epitopes; Respiratory tract; Corynebacterium DO - http://dx.doi.org/10.1007/s10096-008-0483-9 ER - TY - JOUR T1 - A comparison of two word-recognition tasks in multitalker babble: Speech Recognition in Noise Test (SPRINT) and Words-in-Noise Test (WIN). AN - 85380762; pmid-19248731 AB - The Speech Recognition in Noise Test (SPRINT) is a word-recognition instrument that presents the 200 Northwestern University Auditory Test No. 6 (NU-6) words binaurally at 50 dB HL in a multitalker babble at a 9 dB signal-to-noise ratio (S/N) (Cord et al, 1992). The SPRINT was developed by and used by the Army as a more valid predictor of communication abilities (than pure-tone thresholds or word-recognition in quiet) for issues involving fitness for duty from a hearing perspective of Army personnel. The Words-in-Noise test (WIN) is a slightly different word-recognition task in a fixed level multitalker babble with 10 NU-6 words presented at each of 7 S/N from 24 to 0 dB S/N in 4 dB decrements (Wilson, 2003; Wilson and McArdle, 2007). For the two instruments, both the babble and the speakers of the words are different. The SPRINT uses all 200 NU-6 words, whereas the WIN uses a maximum of 70 words.The purpose was to compare recognition performances by 24 young listeners with normal hearing and 48 older listeners with sensorineural hearing on the SPRINT and WIN protocols.A quasi-experimental, mixed model design was used.The 24 young listeners with normal hearing (19 to 29 years, mean = 23.3 years) were from the local university and had normal hearing ( or = 40%, and (5) no history of middle ear or retrocochlear pathology as determined by an audiologic evaluation.The speech materials were presented bilaterally in the following order: (1) the SPRINT at 50 dB HL, (2) two half lists of NU-6 words in quiet at 60 dB HL and 80 dB HL, and (3) the two 35-word lists of the WIN materials with the multitalker babble fixed at 60 dB HL. Data collection occurred during a 40-60 minute session. Recognition performances on each stimulus word were analyzed.The listeners with normal hearing obtained 92.5% correct on the SPRINT with a 50% point on the WIN of 2.7 dB S/N. The listeners with hearing loss obtained 65.3% correct on the SPRINT and a WIN 50% point at 12.0 dB S/N. The SPRINT and WIN were significantly correlated (r = -0.81, p < .01), indicating that the SPRINT had good concurrent validity. The high-frequency, pure-tone average (1000, 2000, 4000 Hz) had higher correlations with the SPRINT, WIN, and NU-6 in quiet than did the traditional three-frequency pure-tone average (500, 1000, 2000 Hz).Graphically and numerically the SPRINT and WIN were highly related, which is indicative of good concurrent validity of the SPRINT. JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AU - Cates, Wendy B AD - VA Medical Center, Audiology (126), Mountain Home, TN 37684, USA. RICHARD.WILSON2@VA.GOV Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 548 EP - 556 VL - 19 IS - 7 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - *Attention KW - Audiometry, Pure-Tone: statistics & numerical data KW - Female KW - Humans KW - Male KW - Middle Aged KW - Noise KW - *Perceptual Masking KW - *Presbycusis: diagnosis KW - Reference Values KW - Reproducibility of Results KW - Social Environment KW - *Speech Reception Threshold Test: methods KW - Young Adult UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85380762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=A+comparison+of+two+word-recognition+tasks+in+multitalker+babble%3A+Speech+Recognition+in+Noise+Test+%28SPRINT%29+and+Words-in-Noise+Test+%28WIN%29.&rft.au=Wilson%2C+Richard+H%3BCates%2C+Wendy+B&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2008-07-01&rft.volume=19&rft.issue=7&rft.spage=548&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The extent to which a position-based explanation accounts for binaural release from informational masking. AN - 742779172; pmid-18646988 AB - Detection was measured for a 500 Hz tone masked by noise (an "energetic" masker) or sets of ten randomly drawn tones (an "informational" masker). Presenting the maskers diotically and the target tone with a variety of interaural differences (interaural amplitude ratios and/or interaural time delays) resulted in reduced detection thresholds relative to when the target was presented diotically ("binaural release from masking"). Thresholds observed when time and amplitude differences applied to the target were "reinforcing" (favored the same ear, resulting in a lateralized position for the target) were not significantly different from thresholds obtained when differences were "opposing" (favored opposite ears, resulting in a centered position for the target). This irrelevance of differences in the perceived location of the target is a classic result for energetic maskers but had not previously been shown for informational maskers. However, this parallellism between the patterns of binaural release for energetic and informational maskers was not accompanied by high correlations between the patterns for individual listeners, supporting the idea that the mechanisms for binaural release from energetic and informational masking are fundamentally different. JF - The Journal of the Acoustical Society of America AU - Gallun, Frederick J AU - Durlach, Nathaniel I AU - Colburn, H Steven AU - Shinn-Cunningham, Barbara G AU - Best, Virginia AU - Mason, Christine R AU - Kidd, Gerald AD - Hearing Research Center, Boston University, 635 Commonwealth Avenue, Boston, Massachusetts 02215, USA. frederick.gallun@va.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 439 EP - 449 VL - 124 IS - 1 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Hearing -- physiology KW - Auditory Threshold KW - Humans KW - Adult KW - Female KW - Noise KW - Perceptual Masking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742779172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=The+extent+to+which+a+position-based+explanation+accounts+for+binaural+release+from+informational+masking.&rft.au=Gallun%2C+Frederick+J%3BDurlach%2C+Nathaniel+I%3BColburn%2C+H+Steven%3BShinn-Cunningham%2C+Barbara+G%3BBest%2C+Virginia%3BMason%2C+Christine+R%3BKidd%2C+Gerald&rft.aulast=Gallun&rft.aufirst=Frederick&rft.date=2008-07-01&rft.volume=124&rft.issue=1&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - SuppNotes - Cites: J Acoust Soc Am. 2007 Aug;122(2):1029-45[17672651]; Cites: J Acoust Soc Am. 1973 Jun;53(6):1553-9[4719251]; Cites: J Acoust Soc Am. 2006 Jun;119(6):3971-86[16838540]; Cites: Proc Natl Acad Sci U S A. 1934 Nov;20(11):593-6[16577646]; Cites: J Acoust Soc Am. 2006 Mar;119(3):1597-605[16583904]; Cites: J Acoust Soc Am. 1972 Jun;51(6):1852-62[5045249]; Cites: J Acoust Soc Am. 1976 Mar;59(3):598-601[1254788]; Cites: J Acoust Soc Am. 1971 Feb;49(2):Suppl 2:467+[5541744]; Cites: J Acoust Soc Am. 1970 Apr;47(4):1041-7[5443150]; Cites: J Acoust Soc Am. 1969 Dec;46(6):1452-7[5361513]; Cites: J Acoust Soc Am. 1966 Dec;40(6):1414-9[5975577]; Cites: J Acoust Soc Am. 2003 Sep;114(3):1543-9[14514207]; Cites: J Acoust Soc Am. 2003 Jul;114(1):368-79[12880048]; Cites: J Acoust Soc Am. 2003 Jun;113(6):2984-7[12822768]; Cites: J Acoust Soc Am. 2002 Nov;112(5 Pt 1):2086-98[12430820]; Cites: J Acoust Soc Am. 1999 Dec;106(6):3578-88[10615698]; Cites: J Acoust Soc Am. 2006 Mar;119(3):1574-84[16583902]; Cites: J Acoust Soc Am. 2005 Dec;118(6):3766-73[16419821]; Cites: J Acoust Soc Am. 2005 Nov;118(5):3241-51[16334903]; Cites: J Acoust Soc Am. 2005 Oct;118(4):2482-97[16266169]; Cites: J Acoust Soc Am. 2005 Sep;118(3 Pt 1):1614-25[16240821]; Cites: J Acoust Soc Am. 1965 Jul;38:93-103[14347607]; Cites: J Acoust Soc Am. 1998 Dec;104(6):3489-99[9857508]; Cites: J Acoust Soc Am. 1995 Oct;98(4):1909-20[7593915]; Cites: J Acoust Soc Am. 1994 Jun;95(6):3475-80[8046139]; Cites: J Acoust Soc Am. 1993 Dec;94(6):3112-26[8300950]; Cites: J Acoust Soc Am. 1993 Aug;94(2 Pt 1):748-58[8370881]; Cites: J Acoust Soc Am. 1987 Feb;81(2):459-64[3558963]; Cites: J Acoust Soc Am. 1983 Sep;74(3):750-3[6630731]; Cites: J Acoust Soc Am. 1977 May;61(5):1298-300[881485]; Cites: J Acoust Soc Am. 2007 Apr;121(4):2127-36[17471727] N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - Neural substrates related to auditory working memory comparisons in dyslexia: an fMRI study. AN - 742774084; pmid-18577292 AB - Adult readers with developmental phonological dyslexia exhibit significant difficulty comparing pseudowords and pure tones in auditory working memory (AWM). This suggests deficient AWM skills for adults diagnosed with dyslexia. Despite behavioral differences, it is unknown whether neural substrates of AWM differ between adults diagnosed with dyslexia and normal readers. Prior neuroimaging of adults diagnosed with dyslexia and normal readers, and post-mortem findings of neural structural anomalies in adults diagnosed with dyslexia support the hypothesis of atypical neural activity in temporoparietal and inferior frontal regions during AWM tasks in adults diagnosed with dyslexia. We used fMRI during two binaural AWM tasks (pseudowords or pure tones comparisons) in adults diagnosed with dyslexia (n = 11) and normal readers (n = 11). For both AWM tasks, adults diagnosed with dyslexia exhibited greater activity in left posterior superior temporal (BA 22) and inferior parietal regions (BA 40) than normal readers. Comparing neural activity between groups and between stimuli contrasts (pseudowords vs. tones), adults diagnosed with dyslexia showed greater primary auditory cortex activity (BA 42; tones > pseudowords) than normal readers. Thus, greater activity in primary auditory, posterior superior temporal, and inferior parietal cortices during linguistic and non-linguistic AWM tasks for adults diagnosed with dyslexia compared to normal readers indicate differences in neural substrates of AWM comparison tasks. JF - Journal of the International Neuropsychological Society : JINS AU - Conway, Tim AU - Heilman, Kenneth M AU - Gopinath, Kaundinya AU - Peck, Kyung AU - Bauer, Russell AU - Briggs, Richard W AU - Torgesen, Joseph K AU - Crosson, Bruce AD - Department of Veterans Affairs Rehabilitation Research and Development Brain Rehabilitation Research Center of Excellence, Malcom Randall Veterans Administration Medical Center, Gainesville, Florida, USA. twc@phhp.ufl.edu Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 629 EP - 639 VL - 14 IS - 4 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Brain Mapping KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Magnetic Resonance Imaging KW - Speech Perception -- physiology KW - Auditory Cortex -- physiopathology KW - Dominance, Cerebral -- physiology KW - Dyslexia -- physiopathology KW - Memory, Short-Term -- physiology KW - Parietal Lobe -- physiopathology KW - Temporal Lobe -- physiopathology KW - Pitch Perception -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742774084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Neural+substrates+related+to+auditory+working+memory+comparisons+in+dyslexia%3A+an+fMRI+study.&rft.au=Conway%2C+Tim%3BHeilman%2C+Kenneth+M%3BGopinath%2C+Kaundinya%3BPeck%2C+Kyung%3BBauer%2C+Russell%3BBriggs%2C+Richard+W%3BTorgesen%2C+Joseph+K%3BCrosson%2C+Bruce&rft.aulast=Conway&rft.aufirst=Tim&rft.date=2008-07-01&rft.volume=14&rft.issue=4&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Depletion of liver glutathione levels in rats: a potential confound of nose-only inhalation. AN - 69330494; 18645729 AB - Nose-only inhalation exposure chambers offer key advantages to whole-body systems, particularly when aerosol or mixed aerosol-vapor exposures are used. Specifically, nose-only chambers provide enhanced control over the route of exposure and dose by minimizing the deposition of particles either on the subjects skin/fur or on surfaces of a whole-body exposure system. In the current series of experiments, liver, brain, and lung total glutathione (GSH) levels were assessed following either nose-only or whole-body exposures to either jet fuel or to clean, filtered air. The data were compared to untreated control subjects. Acute nose-only inhalation exposures of rats resulted in a significant depletion of liver GSH levels both in subjects that were exposed to clean, filtered air as well as those exposed to JP-8 jet fuel and to a synthetic jet fuel. Glutathione levels were not altered in lung or brain tissue. Whole-body inhalation exposure had no effect on GSH levels in any tissue for any of the treatment groups. A second experiment demonstrated that the loss of GSH did not occur if rats were anaesthetized prior to and during nose-only exposure to clean, filtered air or to mixed hydrocarbons. These data appear to be consistent with studies demonstrating depletion in liver GSH levels among rats subjected to restraint stress. Finally, the depletion of GSH that was observed in liver following a single acute exposure was reduced following five daily exposures to clean, filtered air, suggesting the possibility of habituation to restraint in the nose-only exposure chamber. The finding that placement in a nose-only exposure chamber per se yields liver GSH depletion raises the possibility of an interaction between this mode of toxicant exposure and the toxicological effects of certain inhaled test substances. JF - Inhalation toxicology AU - Fechter, Laurence D AU - Nelson-Miller, Alisa AU - Gearhart, Caroline AD - Loma Linda VA Medical Center, Loma Linda, California, USA. Larry.fechter@va.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 885 EP - 890 VL - 20 IS - 9 KW - Hydrocarbons KW - 0 KW - JP8 aviation fuel KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Rats KW - Animals KW - Rats, Long-Evans KW - Confounding Factors (Epidemiology) KW - Oxidative Stress -- drug effects KW - Administration, Inhalation KW - Male KW - Liver -- drug effects KW - Glutathione -- metabolism KW - Brain -- drug effects KW - Liver -- metabolism KW - Atmosphere Exposure Chambers KW - Brain -- metabolism KW - Hydrocarbons -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69330494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Depletion+of+liver+glutathione+levels+in+rats%3A+a+potential+confound+of+nose-only+inhalation.&rft.au=Fechter%2C+Laurence+D%3BNelson-Miller%2C+Alisa%3BGearhart%2C+Caroline&rft.aulast=Fechter&rft.aufirst=Laurence&rft.date=2008-07-01&rft.volume=20&rft.issue=9&rft.spage=885&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.1080%2F08958370801975329 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-04 N1 - Date created - 2008-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/08958370801975329 ER - TY - JOUR T1 - Long-term survival after colon cancer surgery: a variation associated with choice of anesthesia. AN - 69324445; 18635504 AB - A previously published clinical trial of epidural-supplemented versus general anesthesia, Veterans Affairs Cooperative Study No. 345, showed no difference in 30-day mortality and morbidity rates between the two treatments. We hypothesized that long-term postoperative survival would be increased by epidural anesthesia/analgesia supplementation during colon cancer resection. We studied long-term survival after resection of colon cancer in a trial of general anesthesia with and without epidural anesthesia and analgesia supplementation for resection of colon cancer in Veterans Affairs Cooperative Study No. 345. Cox and log-normal survival models were used to test the effects of pathological stage, type of anesthesia and other covariates on survival in 177 patients. The presence of distant metastases had the greatest effect on survival. Thus, analyses were performed separately for patients with and without metastases. For those without metastasis, the hazard ratio for the treatment effects changed at 1.46 years. Before 1.46 years, epidural supplementation was associated with improved survival (P = 0.012), while later, the type of anesthesia did not appear to affect survival (P = 0.27). Hypertension was associated with poorer survival (P = 0.029), as was alcoholism in patients who received epidural anesthesia (P = 0.014). Survival of patients with metastases was unaffected by type of anesthesia. There was a significant age by hypertension interaction (P = 0.002). Patients survived longer if they were hypertensive, but had reduced survival if they were older than 66 years and hypertensive. Epidural supplementation was associated with enhanced survival among patients without metastases before 1.46 years. Epidural anesthesia had no effect on survival of patients with metastases. Additional studies to confirm or refute these findings are warranted. JF - Anesthesia and analgesia AU - Christopherson, Rose AU - James, Kenneth E AU - Tableman, Mara AU - Marshall, Prudence AU - Johnson, Frank E AD - Anesthesiology Service, VA Medical Center and Department of Anesthesiology, OR Health and Science University, Portland, OR 97229, USA. rose.christopherson@med.va.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 325 EP - 332 VL - 107 IS - 1 KW - Abridged Index Medicus KW - Index Medicus KW - Hypertension -- complications KW - Probability KW - Randomized Controlled Trials as Topic KW - Age Factors KW - Neoplasm Staging KW - Humans KW - Neoplasm Metastasis KW - Aged KW - Middle Aged KW - Alcoholism -- complications KW - Proportional Hazards Models KW - Colonic Neoplasms -- mortality KW - Colonic Neoplasms -- surgery KW - Colonic Neoplasms -- pathology KW - Anesthesia, Epidural -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69324445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Long-term+survival+after+colon+cancer+surgery%3A+a+variation+associated+with+choice+of+anesthesia.&rft.au=Christopherson%2C+Rose%3BJames%2C+Kenneth+E%3BTableman%2C+Mara%3BMarshall%2C+Prudence%3BJohnson%2C+Frank+E&rft.aulast=Christopherson&rft.aufirst=Rose&rft.date=2008-07-01&rft.volume=107&rft.issue=1&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=1526-7598&rft_id=info:doi/10.1213%2Fane.0b013e3181770f55 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-21 N1 - Date created - 2008-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1213/ane.0b013e3181770f55 ER - TY - JOUR T1 - Racial/Ethnic disparities in the use of nicotine replacement therapy and quit ratios in lifetime smokers ages 25 to 44 years. AN - 69314527; 18583471 AB - We examined racial/ethnic variations in the use of nicotine replacement therapy (NRT) and quit ratios among Caucasian, African American, Asian, and Latino lifetime smokers ages 25 to 44 years. We conducted cross-sectional analyses using data from individuals (n = 27,031) screened for enrollment in the Collaborative Study of the Genetics of Nicotine Dependence. Participants were randomly sampled from three Midwestern metropolitan areas using Health Maintenance Organization membership lists in Detroit, MI and Minneapolis, MN and a driver's license registry in St. Louis, MO from March 2003 to August 2005. A telephone survey collected information on smoking history, previous quit attempts, and sociodemographic characteristics. Among lifetime smokers (n = 9,216), univariate analysis indicated that African Americans (22%) and Latinos (22%) were significantly less likely to report having ever used NRT for smoking cessation than Caucasians (31%). Asians (22%) also reported lower rates of using NRT than Caucasians, but this difference was marginally significant (P = 0.06). These disparities persisted in multivariate analysis for African Americans [adjusted odds ratio (OR), 0.76; 95% confidence interval (95% CI), 0.63-0.91; P < 0.01] but not for Latinos (adjusted OR, 0.76; 95% CI, 0.54-1.06; P = 0.11) or Asians (adjusted OR, 0.98; 95% CI, 0.60-1.60; P = 0.95). As measured by the quit ratio, African Americans (35%) were less likely to have quit smoking than Caucasians (52%). This disparity persisted in multivariate logistic regression (adjusted OR, 0.66; 95% CI, 0.56-0.78; P < 0.001). Asian and Latino smokers were as likely as Caucasians to report smoking cessation. Future prospective studies are needed to assess whether lower utilization of cessation treatments such as NRT contribute to the observed disparity in quit ratios for African Americans. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Fu, Steven S AU - Kodl, Molly M AU - Joseph, Anne M AU - Hatsukami, Dorothy K AU - Johnson, Eric O AU - Breslau, Naomi AU - Wu, Baolin AU - Bierut, Laura AD - Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center (152/2E), Minneapolis, MN 55417, USA. Steven.Fu@va.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 1640 EP - 1647 VL - 17 IS - 7 SN - 1055-9965, 1055-9965 KW - Nicotinic Agonists KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Cross-Sectional Studies KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Retrospective Studies KW - United States -- epidemiology KW - Male KW - Female KW - Ethnic Groups -- ethnology KW - Nicotinic Agonists -- therapeutic use KW - Tobacco Use Disorder -- drug therapy KW - Nicotine -- analogs & derivatives KW - Tobacco Use Disorder -- ethnology KW - Smoking Cessation -- ethnology KW - Smoking Cessation -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69314527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Racial%2FEthnic+disparities+in+the+use+of+nicotine+replacement+therapy+and+quit+ratios+in+lifetime+smokers+ages+25+to+44+years.&rft.au=Fu%2C+Steven+S%3BKodl%2C+Molly+M%3BJoseph%2C+Anne+M%3BHatsukami%2C+Dorothy+K%3BJohnson%2C+Eric+O%3BBreslau%2C+Naomi%3BWu%2C+Baolin%3BBierut%2C+Laura&rft.aulast=Fu&rft.aufirst=Steven&rft.date=2008-07-01&rft.volume=17&rft.issue=7&rft.spage=1640&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-07-2726 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-25 N1 - Date created - 2008-07-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Prev Med. 2000 May;18(4):305-11 [10788733] Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):617-9 [17337647] J Fam Pract. 2000 Jun;49(6):543-7 [10923556] Am J Public Health. 2001 Feb;91(2):213-8 [11211629] Am J Public Health. 2002 Mar;92(3):437-42 [11867326] Nicotine Tob Res. 2002 May;4(2):149-59 [12028847] Tob Control. 2002 Jun;11(2):135-9 [12035007] Am J Public Health. 2002 Jun;92(6):961-5 [12036790] Am J Public Health. 2002 Jun;92(6):990-6 [12036794] Oncogene. 2002 Oct 21;21(48):7326-40 [12379876] Tob Control. 2002 Dec;11(4):368-71 [12432163] Addiction. 2003 Oct;98(10):1387-93 [14519175] Ann Intern Med. 2003 Dec 2;139(11):907-15 [14644893] Am J Prev Med. 2004 Feb;26(2):105-11 [14751320] Nicotine Tob Res. 2004 Feb;6 Suppl 1:S5-9 [14982704] Nicotine Tob Res. 2004 Feb;6 Suppl 1:S67-81 [14982710] J Natl Med Assoc. 2004 Sep;96(9):1208-11 [15481749] Am J Public Health. 2004 Nov;94(11):1965-71 [15514238] Med Care. 1987 May;25(5):437-51 [3695654] Am J Public Health. 1988 Sep;78(9):1187-9 [3407817] Am J Public Health. 1993 Feb;83(2):220-6 [8427327] J Natl Med Assoc. 1996 Apr;88(4):249-52 [8648661] JAMA. 1997 Jan 22-29;277(4):350-6 [9002500] J Addict Dis. 2005;24(1):101-13 [15774414] Am J Health Promot. 2005 Nov-Dec;20(2):108-16 [16295702] Arch Intern Med. 2006 Sep 25;166(17):1915-22 [17000950] MMWR Morb Mortal Wkly Rep. 2006 Oct 27;55(42):1145-8 [17065979] Prev Med. 2007 Mar;44(3):235-40 [17175016] Prev Med. 2000 Jul;31(1):23-38 [10896841] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-07-2726 ER - TY - JOUR T1 - Treatment-seeking veterans of Iraq and Afghanistan: comparison with veterans of previous wars. AN - 69312010; 18626291 AB - Differences in the characteristics and mental health needs of veterans of the Iraq/Afghanistan war when compared with those of veterans who served in the Persian Gulf war and in the Vietnam war may have important implications for Veterans Affairs (VA) program and treatment planning. Subjects were drawn from administrative data bases of veterans who sought treatment from specialized VA programs for treatment of posttraumatic stress disorder (PTSD). Current Iraq/Afghanistan veterans were compared with 4 samples of outpatient and inpatient Persian Gulf and Vietnam veterans whose admission to treatment was either contemporaneous or noncontemporaneous with their admission. A series of analyses of covariance was used hierachically to control for program site and age. In analyses of contemporaneous veterans uncontrolled for age, Iraq/Afghanistan veterans differed most notably from Vietnam veterans by being younger, more likely to be female, less likely to be either married or separated/divorced, more often working, less likely to have ever been incarcerated, and less likely to report exposure to atrocities in the military. Regarding clinical status, Iraq/Afghanistan veterans were less often diagnosed with substance abuse disorders, manifested more violent behavior, and had lower rates of VA disability compensation because of PTSD. Differences are more muted in comparisons with Persian Gulf veterans, particularly in those involving noncontemporaneous samples, or those that controlled for age differences. Among recent war veterans with PTSD, social functioning has largely been left intact. There is a window of opportunity, therefore, for developing and focusing on treatment interventions that emphasize the preservation of these social assets. JF - The Journal of nervous and mental disease AU - Fontana, Alan AU - Rosenheck, Robert AD - New England Mental Illness Research, Education and Clinical Center, West Haven, Connecticut, USA. alan.fontana@va.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 513 EP - 521 VL - 196 IS - 7 KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Humans KW - Social Behavior KW - Persian Gulf Syndrome -- therapy KW - Persian Gulf Syndrome -- psychology KW - Afghanistan KW - Combat Disorders -- epidemiology KW - Iraq KW - Combat Disorders -- therapy KW - Combat Disorders -- psychology KW - Adult KW - Cohort Studies KW - Vietnam Conflict KW - Persian Gulf Syndrome -- epidemiology KW - Middle Aged KW - Female KW - Male KW - Warfare KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Stress Disorders, Post-Traumatic -- therapy KW - Stress Disorders, Post-Traumatic -- psychology KW - Veterans -- psychology KW - Patient Acceptance of Health Care -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69312010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=Treatment-seeking+veterans+of+Iraq+and+Afghanistan%3A+comparison+with+veterans+of+previous+wars.&rft.au=Fontana%2C+Alan%3BRosenheck%2C+Robert&rft.aulast=Fontana&rft.aufirst=Alan&rft.date=2008-07-01&rft.volume=196&rft.issue=7&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=1539-736X&rft_id=info:doi/10.1097%2FNMD.0b013e31817cf6e6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-04 N1 - Date created - 2008-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/NMD.0b013e31817cf6e6 ER - TY - JOUR T1 - Expenditures in mental illness and substance use disorders among veteran clinic users with diabetes. AN - 69308798; 18512155 AB - Few studies have looked at the health-care expenditures of diabetes patients based on the type of co-occurring conditions of mental illness (MI) or substance use disorders (SUD). Our study analyzes the health-care expenditures associated with various diagnostic clusters of co-occurring drug, alcohol, tobacco use, and mental illness in veterans with diabetes. We merged Veteran Health Administration and Medicare fee-for-service claims database (fiscal years 1999 and 2000) for analysis (N = 390,253) using generalized linear models; SUD/MI were identified using International Classification of Diseases, 9th edition codes. The total average expenditures (fiscal year 2000) were lowest ($6,185) in the "No MI and No SUD" and highest ($19,801) for individuals with schizophrenia/other psychoses and alcohol/drug use. High expenditures were associated with both SUD and MI conditions in diabetes patients, and veterans with alcohol/drug use had the highest expenditures across all groups of MI. These findings reinforce the need to target groups with multiple comorbidities specifically those with serious mental illnesses and alcohol/drug use for interventions to reduce health-care expenditures. JF - The journal of behavioral health services & research AU - Banerjea, Ranjana AU - Sambamoorthi, Usha AU - Smelson, David AU - Pogach, Leonard M AD - Center for Healthcare Knowledge Management, VA New Jersey Healthcare System, East Orange, NJ, USA. Ranjana.Banerjea@va.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 290 EP - 303 VL - 35 IS - 3 KW - Index Medicus KW - United States KW - Humans KW - Male KW - Female KW - Comorbidity KW - Veterans KW - Diabetes Mellitus -- economics KW - Substance-Related Disorders -- economics KW - Mental Disorders -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69308798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+behavioral+health+services+%26+research&rft.atitle=Expenditures+in+mental+illness+and+substance+use+disorders+among+veteran+clinic+users+with+diabetes.&rft.au=Banerjea%2C+Ranjana%3BSambamoorthi%2C+Usha%3BSmelson%2C+David%3BPogach%2C+Leonard+M&rft.aulast=Banerjea&rft.aufirst=Ranjana&rft.date=2008-07-01&rft.volume=35&rft.issue=3&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=The+journal+of+behavioral+health+services+%26+research&rft.issn=1556-3308&rft_id=info:doi/10.1007%2Fs11414-008-9120-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-29 N1 - Date created - 2008-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s11414-008-9120-8 ER - TY - JOUR T1 - Critical care in the austere environment: providing exceptional care in unusual places. AN - 69287544; 18594254 AB - War and other disasters are inexorably linked to illness and injury. As a consequence of this, healthcare providers will be challenged to provide advanced physiological support to preserve human life. Given the mobility and modularity of modern medical systems, the ability to provide critical care outside of the confines of traditional hospitals under such circumstances has become not only a reality and periodic necessity, but an expectation. Austerity amplifies the complexity of providing high-level critical care, because resources are frequently limited, providers are asked to fill unexpected roles determined by necessity, security may be threatened, and the population at risk and their afflictions can be highly diverse. Our current deployed military medical experience and a review of published literature pertaining to civilian medical disaster response efforts support these stated challenges. The fundamentals of successful critical care practice in unusual settings include proper planning with an emphasis on attention to detail, the careful management of all resources, using the proper equipment, leveraging aeromedical evacuation assets, and employing the right people with the right skills. Adherence to sound, evidence-based, routine practice, within bounds of the circumstances, must underscore everything. JF - Critical care medicine AU - Venticinque, Steven G AU - Grathwohl, Kurt W AD - Department of Anesthesiology (SGV), University of Texas Health Science Center, San Antonio, TX, USA. steven.venticinque@va.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - S284 EP - S292 VL - 36 IS - 7 Suppl KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Triage -- organization & administration KW - Oxygen Inhalation Therapy -- methods KW - Humans KW - Mobile Health Units -- organization & administration KW - Occupational Diseases -- prevention & control KW - Stress Disorders, Post-Traumatic -- prevention & control KW - Afghanistan KW - Resuscitation -- methods KW - Mass Casualty Incidents -- prevention & control KW - Iraq KW - Patient Care Team -- organization & administration KW - Disaster Planning -- organization & administration KW - Iraq War, 2003-2011 KW - Transportation of Patients -- organization & administration KW - Quality Assurance, Health Care -- organization & administration KW - Point-of-Care Systems -- organization & administration KW - Resource Allocation -- organization & administration KW - Hospitals, Packaged -- organization & administration KW - Military Medicine -- organization & administration KW - Medically Underserved Area KW - Critical Care -- organization & administration KW - Health Facility Environment -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69287544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+care+medicine&rft.atitle=Critical+care+in+the+austere+environment%3A+providing+exceptional+care+in+unusual+places.&rft.au=Venticinque%2C+Steven+G%3BGrathwohl%2C+Kurt+W&rft.aulast=Venticinque&rft.aufirst=Steven&rft.date=2008-07-01&rft.volume=36&rft.issue=7+Suppl&rft.spage=S284&rft.isbn=&rft.btitle=&rft.title=Critical+care+medicine&rft.issn=1530-0293&rft_id=info:doi/10.1097%2FCCM.0b013e31817da8ec LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-13 N1 - Date created - 2008-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CCM.0b013e31817da8ec ER - TY - JOUR T1 - Pain, substance use disorders and opioid analgesic prescription patterns in veterans with hepatitis C. AN - 69268058; 18358690 AB - To examine the prevalence of pain, substance use disorder (SUD) diagnoses, and opioid analgesic prescription patterns among veterans infected with the hepatitis C virus (HCV), a retrospective review of the medical records of 8,224 HCV-positive (HCV+) veterans was performed. Twenty-nine percent and 46% of HCV+ patients were prescribed opioids in the prior one and three years, respectively. Sixty-seven percent of HCV+ patients had documented pain diagnoses and 56% had SUD diagnoses. Patients with co-occurring pain and SUD were less likely to be prescribed opioids than patients with pain only (prior year: 36% vs. 43%, P<0.001; three years: 56% vs. 60%, P<0.01). There were no differences in numbers of early opioid prescription fills or numbers of opioid prescribers when comparing patients with co-occurring pain and SUD to patients with pain only. Veterans with co-occurring pain and opioid use disorder had fewer early opioid fills than veterans with pain only (prior year: 2.6 vs. 5.3 days, P<0.01; three years: 6.1 vs. 13.4 days, P<0.001). These data demonstrate that pain and SUD diagnoses were common among HCV+ patients, and that opioids were frequently prescribed. Co-occurring SUD was not associated with indicators of prescription opioid misuse. JF - Journal of pain and symptom management AU - Whitehead, Ashlee J AU - Dobscha, Steven K AU - Morasco, Benjamin J AU - Ruimy, Samantha AU - Bussell, Cara AU - Hauser, Peter AD - Northwest Hepatitis C Resource Center, Portland, OR, USA. ashlee.whitehead@va.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 39 EP - 45 VL - 36 IS - 1 KW - Analgesics, Opioid KW - 0 KW - Index Medicus KW - Humans KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Comorbidity KW - Prevalence KW - Pain -- drug therapy KW - Opioid-Related Disorders -- epidemiology KW - Hepatitis C -- drug therapy KW - Pain -- epidemiology KW - Hepatitis C -- epidemiology KW - Analgesics, Opioid -- administration & dosage KW - Substance-Related Disorders -- prevention & control KW - Substance-Related Disorders -- epidemiology KW - Drug Prescriptions -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69268058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pain+and+symptom+management&rft.atitle=Pain%2C+substance+use+disorders+and+opioid+analgesic+prescription+patterns+in+veterans+with+hepatitis+C.&rft.au=Whitehead%2C+Ashlee+J%3BDobscha%2C+Steven+K%3BMorasco%2C+Benjamin+J%3BRuimy%2C+Samantha%3BBussell%2C+Cara%3BHauser%2C+Peter&rft.aulast=Whitehead&rft.aufirst=Ashlee&rft.date=2008-07-01&rft.volume=36&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+pain+and+symptom+management&rft.issn=1873-6513&rft_id=info:doi/10.1016%2Fj.jpainsymman.2007.08.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-23 N1 - Date created - 2008-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jpainsymman.2007.08.013 ER - TY - JOUR T1 - Nonaspirin NSAIDs, cyclooxygenase 2 inhibitors, and the risk for stroke. AN - 69250730; 18436878 AB - There is limited information regarding the cerebrovascular safety of cyclooxygenase 2 inhibitors (coxibs) and noncoxib nonsteroidal antiinflammatory drugs (NSAIDs). We determined whether specific NSAIDs, including coxibs, are associated with risk of stroke. Retrospective cohort study among Tennessee Medicaid enrollees aged 50 to 84 years between January 1, 1999 and December 31, 2004. Noninstitutionalized persons with continuous enrollment in Medicaid and no stroke or other serious medical illness in the year before cohort entry were included. The 7 most common NSAIDs were examined: celecoxib, rofecoxib, valdecoxib, ibuprofen, naproxen, diclofenac, and indomethacin. Nonuse of NSAIDs was the reference group. Because new use is less susceptible to bias, we conducted a similar analysis confined to new users. The outcome was hospitalization for an incident cerebrovascular event: ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage. The cohort included 336,906 persons, with 989,826 person-years of follow-up, and 4354 stroke hospitalizations. There were 4.51 strokes per 1000 person years in the nonuse group, 5.15 strokes per 1000 person years (adjusted HR 1.28, 95% CI 1.06, 1.53) with rofecoxib use, and 5.95 strokes per 1000 person years (adjusted HR 1.41, 95% CI 1.04, 1.91) with valdecoxib use. New use of rofecoxib and valdecoxib led to 6.06 (adjusted HR 1.46 95% CI 1.08, 1.98) and 6.19 (adjusted HR 1.39, 95% CI 0.74, 2.59) strokes per 1000 person years respectively. No other NSAID significantly increased the risk of incident stroke. Our results indicate an increased risk of stroke with current use of two highly selective coxibs, rofecoxib and valdecoxib, also shown to increase cardiovascular risk. These results also provide some reassurance about other specific NSAIDs regarding stroke risk. JF - Stroke AU - Roumie, Christianne L AU - Mitchel, Edward F AU - Kaltenbach, Lisa AU - Arbogast, Patrick G AU - Gideon, Patricia AU - Griffin, Marie R AD - Veterans Administration, Tennessee Valley Healthcare System, Tennessee Valley Geriatric Research Education Clinical Center, Nashville, TN 37212, USA. christianne.roumie@vanderbilt.edu Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 2037 EP - 2045 VL - 39 IS - 7 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase 2 Inhibitors KW - Index Medicus KW - Risk KW - Aged, 80 and over KW - Risk Factors KW - Humans KW - Cohort Studies KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Cardiovascular Diseases -- chemically induced KW - Male KW - Female KW - Cardiovascular Diseases -- prevention & control KW - Cyclooxygenase 2 Inhibitors -- pharmacology KW - Stroke -- etiology KW - Stroke -- prevention & control KW - Stroke -- chemically induced KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69250730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stroke&rft.atitle=Nonaspirin+NSAIDs%2C+cyclooxygenase+2+inhibitors%2C+and+the+risk+for+stroke.&rft.au=Roumie%2C+Christianne+L%3BMitchel%2C+Edward+F%3BKaltenbach%2C+Lisa%3BArbogast%2C+Patrick+G%3BGideon%2C+Patricia%3BGriffin%2C+Marie+R&rft.aulast=Roumie&rft.aufirst=Christianne&rft.date=2008-07-01&rft.volume=39&rft.issue=7&rft.spage=2037&rft.isbn=&rft.btitle=&rft.title=Stroke&rft.issn=1524-4628&rft_id=info:doi/10.1161%2FSTROKEAHA.107.508549 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-23 N1 - Date created - 2008-06-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1161/STROKEAHA.107.508549 ER - TY - JOUR T1 - Effective doses in radiology and diagnostic nuclear medicine: a catalog. AN - 69230217; 18566177 AB - Medical uses of radiation have grown very rapidly over the past decade, and, as of 2007, medical uses represent the largest source of exposure to the U.S. population. Most physicians have difficulty assessing the magnitude of exposure or potential risk. Effective dose provides an approximate indicator of potential detriment from ionizing radiation and should be used as one parameter in evaluating the appropriateness of examinations involving ionizing radiation. The purpose of this review is to provide a compilation of effective doses for radiologic and nuclear medicine procedures. Standard radiographic examinations have average effective doses that vary by over a factor of 1000 (0.01-10 mSv). Computed tomographic examinations tend to be in a more narrow range but have relatively high average effective doses (approximately 2-20 mSv), and average effective doses for interventional procedures usually range from 5-70 mSv. Average effective dose for most nuclear medicine procedures varies between 0.3 and 20 mSv. These doses can be compared with the average annual effective dose from background radiation of about 3 mSv. (c) RSNA, 2008. JF - Radiology AU - Mettler, Fred A AU - Huda, Walter AU - Yoshizumi, Terry T AU - Mahesh, Mahadevappa AD - Department of Radiology and Nuclear Medicine, New Mexico Veterans Administration Healthcare System, 1501 San Pedro Blvd, Albuquerque, NM 87108, USA. fmettler@salud.unm.edu Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 254 EP - 263 VL - 248 IS - 1 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Radiation Dosage KW - Relative Biological Effectiveness KW - Nuclear Medicine -- standards KW - Radiology -- standards KW - Tomography, X-Ray Computed -- standards KW - Risk Assessment -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69230217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Effective+doses+in+radiology+and+diagnostic+nuclear+medicine%3A+a+catalog.&rft.au=Mettler%2C+Fred+A%3BHuda%2C+Walter%3BYoshizumi%2C+Terry+T%3BMahesh%2C+Mahadevappa&rft.aulast=Mettler&rft.aufirst=Fred&rft.date=2008-07-01&rft.volume=248&rft.issue=1&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=1527-1315&rft_id=info:doi/10.1148%2Fradiol.2481071451 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-18 N1 - Date created - 2008-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1148/radiol.2481071451 ER - TY - JOUR T1 - Social Disadvantage and the Mental Health of Military Personnel Returning from Iraq and Afghanistan AN - 57268225; 200822068 AB - A discussion of the link between social disadvantage and PTSD, and the lessons we can learn from Vietnam era veterans. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - Luchins, Daniel J AD - Jesse Brown VAMC, 820 S. Damen Ave, Chicago, IL 60612, USA daniel.luchins@va.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 270 EP - 271 PB - Springer, Dordrecht The Netherlands VL - 35 IS - 4 SN - 0894-587X, 0894-587X KW - Veterans KW - Posttraumatic stress disorder KW - Vietnam War KW - Social class KW - Military personnel KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57268225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Social+Disadvantage+and+the+Mental+Health+of+Military+Personnel+Returning+from+Iraq+and+Afghanistan&rft.au=Luchins%2C+Daniel+J&rft.aulast=Luchins&rft.aufirst=Daniel&rft.date=2008-07-01&rft.volume=35&rft.issue=4&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-008-0169-8 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Military personnel; Social class; Veterans; Vietnam War DO - http://dx.doi.org/10.1007/s10488-008-0169-8 ER - TY - JOUR T1 - Tumors skew endothelial cells to disrupt NK cell, T-cell and macrophage functions AN - 20824426; 8311460 AB - Introduction: Patients and mice with solid tumors, such as Lewis lung carcinoma (LLC), have defects in functions of immune effector cells. Endothelial cells, a component of the tumor vasculature, are potential regulators of immune cell functions. Therefore, these studies examined the impact of exposure to LLC tumor on the ability of endothelial cells to modulate immune cell functions. Materials and methods: Endothelial cells were pre-treated with LLC tumor-conditioned medium (Endo super(T-sup)) for 24 h. Control endothelial cells that were exposed to medium (Endo super(Media)) or epithelial cell-conditioned medium (Endo super(Epi-sup)). After the initial 24 h incubation, endothelial cells were washed and fresh media was added. Cells were allowed to incubate for an additional 24 h. Supernatants from Endo super(Media), Endo super(Epi-sup) or Endo super(T-sup) were collected and assayed for immune modulatory products and for immune modulatory activity. Results: Supernatant from Endo super(T-sup) contained increased levels of PGE sub(2), IL-6 and VEGF as compared to Endo super(Media) and Endo super(Epi-sup) controls. NK cell activity, as measured by TNF- alpha and IFN- gamma secretion, was increased following exposure to media conditioned by Endo super(Media) and Endo super(Epi-sup). Exposure of NK cells to supernatants of Endo super(T-sup), also increases TNF- alpha and IFN- gamma secretion, but to a lesser extent than by Endo super(Media) and Endo super(Epi-sup). Examination of macrophage functions demonstrated that supernatant from Endo super(T-sup) decreased microbead phagocytosis and increased production of the immune suppressive mediators, IL-10 and PGE sub(2). Lastly, T-cell responses to stimulation with anti-CD3 in the presence of supernatants from Endo super(T-sup) were examined. IFN- gamma production by CD8 super(+) T-cells was reduced after exposure to Endo super(T-sup)-conditioned medium, as compared to cells treatments with medium or control conditioned medium. Production of IFN- gamma by CD4 super(+) T-cells exposed to Endo super(T-sup) was not altered. Conclusions: Taken together, these studies demonstrate that tumors skew endothelial cells to disrupt NK cell, T-cell and macrophages functions, and represents a novel mechanism of tumor-induced immune suppression. JF - Cancer Immunology, Immunotherapy AU - Mulligan, Jennifer K AU - Lathers, Deanne MR AU - Young, MRita I AD - Research Service (151), Ralph H. Johnson VA Medical Center, 109 Bee Street, Charleston, SC, 29401, USA, rita.young@va.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 951 EP - 961 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 57 IS - 7 SN - 0340-7004, 0340-7004 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Macrophages KW - Vascular endothelial growth factor KW - Interleukin 6 KW - gamma -Interferon KW - Solid tumors KW - Lung carcinoma KW - Immunotherapy KW - Natural killer cells KW - Prostaglandin E2 KW - Tumors KW - CD8 antigen KW - Interleukin 10 KW - Effector cells KW - Endothelial cells KW - CD4 antigen KW - Lymphocytes T KW - microspheres KW - Tumor necrosis factor- alpha KW - Phagocytosis KW - F 06915:Cancer Immunology KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20824426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Immunology%2C+Immunotherapy&rft.atitle=Tumors+skew+endothelial+cells+to+disrupt+NK+cell%2C+T-cell+and+macrophage+functions&rft.au=Mulligan%2C+Jennifer+K%3BLathers%2C+Deanne+MR%3BYoung%2C+MRita+I&rft.aulast=Mulligan&rft.aufirst=Jennifer&rft.date=2008-07-01&rft.volume=57&rft.issue=7&rft.spage=951&rft.isbn=&rft.btitle=&rft.title=Cancer+Immunology%2C+Immunotherapy&rft.issn=03407004&rft_id=info:doi/10.1007%2Fs00262-007-0425-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Vascular endothelial growth factor; Macrophages; gamma -Interferon; Lung carcinoma; Solid tumors; Immunotherapy; Natural killer cells; CD8 antigen; Tumors; Prostaglandin E2; Interleukin 10; Effector cells; Endothelial cells; CD4 antigen; microspheres; Lymphocytes T; Tumor necrosis factor- alpha; Phagocytosis DO - http://dx.doi.org/10.1007/s00262-007-0425-x ER - TY - JOUR T1 - In Vivo Comparison of Changes in Glenohumeral Translation After Arthroscopic Capsulolabral Reconstructions AN - 20750006; 10095300 AB - Background: The objective of this study was to quantify anteroposterior glenohumeral translation of patients undergoing arthroscopic capsulolabral repairs using cutaneous electromagnetic position sensors.Hypothesis: Anteroposterior translation will be restored after arthroscopic capsulolabral repairs to values similar to the contralateral or uninjured shoulder.Study Design: Cohort study; Level of evidence, 2.Methods: With use of an electromagnetic tracking system, preoperative anteroposterior translation was measured in the injured and uninvolved shoulders of 32 patients with a diagnosis of glenohumeral labral tears. Testing was done with patients placed in the supine position with the arm suspended in 90 degree of abduction and neutral rotation. The American Shoulder and Elbow Society index and range of motion were also measured. Patients with capsulolabral injuries requiring arthroscopic repair were reexamined at 3 and 6 months postoperatively.Results: In patients with anteroinferior/posteroinferior capsulolabral repairs, glenohumeral translation at 3 and 6 months postoperative (P < .0001) was significantly decreased compared with preoperative values (P = .0007) and the uninvolved side (preoperative, P = .04; postoperative, P = .002). In patients with superior capsulolabral (superior labral anterior-posterior) repairs, the mean glenohumeral translation at 3 and 6 months postoperative was decreased significantly compared with the preoperative value; however, no significant differences were found between the uninvolved side (preoperative, P = .5) and the operative shoulder (postoperative, P = .2). By 6-month follow-up, no significant difference existed in external rotation when compared with preoperative values for either repair group.Conclusion: Arthroscopic superior capsulolabral reconstructions successfully restored anteroposterior translation. However, arthroscopic capsulolabral techniques for treating recurrent anterior or posterior instability resulted in decreased anteroposterior translation compared to the uninvolved side while restoring external rotation. JF - American Journal of Sports Medicine AU - Magit, David P AU - Tibone, James E AU - Lee, Thay Q AD - Kerlan Jobe Orthopaedic Clinic, Los Angeles, California, tqlee@med.va.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 1389 EP - 1396 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 36 IS - 7 SN - 0363-5465, 0363-5465 KW - Health & Safety Science Abstracts; Physical Education Index KW - sports related injuries KW - Evaluation KW - Measurement KW - Injuries KW - Elbows KW - Flexibility KW - Techniques KW - Patients KW - Shoulders KW - Sports medicine KW - H 11000:Diseases/Injuries/Trauma KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20750006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=In+Vivo+Comparison+of+Changes+in+Glenohumeral+Translation+After+Arthroscopic+Capsulolabral+Reconstructions&rft.au=Magit%2C+David+P%3BTibone%2C+James+E%3BLee%2C+Thay+Q&rft.aulast=Magit&rft.aufirst=David&rft.date=2008-07-01&rft.volume=36&rft.issue=7&rft.spage=1389&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F0363546508315199 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Evaluation; Measurement; Injuries; Elbows; Flexibility; Techniques; Shoulders; Patients; Sports medicine; sports related injuries DO - http://dx.doi.org/10.1177/0363546508315199 ER - TY - JOUR T1 - Neurotoxic lesions at the ventral mesopontine junction change sleep time and muscle activity during sleep: an animal model of motor disorders in sleep. AN - 69225414; 18487021 AB - There is no adequate animal model of restless legs syndrome (RLS) and periodic leg movements disorder (PLMD), disorders affecting 10% of the population. Similarly, there is no model of rapid eye movement (REM) sleep behavior disorder (RBD) that explains its symptoms and its link to Parkinsonism. We previously reported that the motor inhibitory system in the brainstem extends from the medulla to the ventral mesopontine junction (VMPJ). We now examine the effects of damage to the VMPJ in the cat. Based on the lesion sites and the changes in sleep pattern and behavior, we saw three distinct syndromes resulting from such lesions; the rostrolateral, rostromedial and caudal VMPJ syndromes. The change in sleep pattern was dependent on the lesion site, but was not significantly correlated with the number of dopaminergic neurons lost. An increase in wakefulness and a decrease in slow wave sleep (SWS) and REM sleep were seen in the rostrolateral VMPJ-lesioned animals. In contrast, the sleep pattern was not significantly changed in the rostromedial and caudal VMPJ-lesioned animals. All three groups of animals showed a significant increase in periodic and isolated leg movements in SWS and increased tonic muscle activity in REM sleep. Beyond these common symptoms, an increase in phasic motor activity in REM sleep, resembling that seen in human RBD, was found in the caudal VMPJ-lesioned animals. In contrast, the increase in motor activity in SWS in rostral VMPJ-lesioned animals is similar to that seen in human RLS/PLMD patients. The proximity of the VMPJ region to the substantia nigra suggests that the link between RLS/PLMD and Parkinsonism, as well as the progression from RBD to Parkinsonism may be mediated by the spread of damage from the regions identified here into the substantia nigra. JF - Neuroscience AU - Lai, Y-Y AU - Hsieh, K-C AU - Nguyen, D AU - Peever, J AU - Siegel, J M AD - Department of Psychiatry and Biobehavioral Science, Neurobiology Research, David Geffen School of Medicine, UCLA and Veterans Administration Greater Los Angeles Healthcare System Sepulveda, North Hills, CA 91343, USA. yylai@ucla.edu Y1 - 2008/06/23/ PY - 2008 DA - 2008 Jun 23 SP - 431 EP - 443 VL - 154 IS - 2 SN - 0306-4522, 0306-4522 KW - Excitatory Amino Acid Agonists KW - 0 KW - N-Methylaspartate KW - 6384-92-5 KW - Index Medicus KW - Animals KW - Electroencephalography KW - Disease Models, Animal KW - Motor Activity -- physiology KW - Brain Stem -- physiology KW - Electric Stimulation KW - Excitatory Amino Acid Agonists -- toxicity KW - Behavior, Animal -- drug effects KW - Polysomnography KW - Movement -- physiology KW - Cats KW - N-Methylaspartate -- toxicity KW - Behavior, Animal -- physiology KW - Data Interpretation, Statistical KW - Female KW - Male KW - Sleep -- drug effects KW - Sleep Wake Disorders -- chemically induced KW - Sleep Wake Disorders -- psychology KW - Muscle, Skeletal -- physiopathology KW - Pons -- physiology KW - Sleep Wake Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69225414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Neurotoxic+lesions+at+the+ventral+mesopontine+junction+change+sleep+time+and+muscle+activity+during+sleep%3A+an+animal+model+of+motor+disorders+in+sleep.&rft.au=Lai%2C+Y-Y%3BHsieh%2C+K-C%3BNguyen%2C+D%3BPeever%2C+J%3BSiegel%2C+J+M&rft.aulast=Lai&rft.aufirst=Y-Y&rft.date=2008-06-23&rft.volume=154&rft.issue=2&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2008.03.085 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-29 N1 - Date created - 2008-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuroscience.2008.03.085 ER - TY - JOUR T1 - Predicting word-recognition performance in noise by young listeners with normal hearing using acoustic, phonetic, and lexical variables. AN - 85381566; pmid-19253783 AB - To analyze the 50% correct recognition data that were from the Wilson et al (this issue) study and that were obtained from 24 listeners with normal hearing; also to examine whether acoustic, phonetic, or lexical variables can predict recognition performance for monosyllabic words presented in speech-spectrum noise.The specific variables are as follows: (a) acoustic variables (i.e., effective root-mean-square sound pressure level, duration), (b) phonetic variables (i.e., consonant features such as manner, place, and voicing for initial and final phonemes; vowel phonemes), and (c) lexical variables (i.e., word frequency, word familiarity, neighborhood density, neighborhood frequency).The descriptive, correlational study will examine the influence of acoustic, phonetic, and lexical variables on speech recognition in noise performance.Regression analysis demonstrated that 45% of the variance in the 50% point was accounted for by acoustic and phonetic variables whereas only 3% of the variance was accounted for by lexical variables. These findings suggest that monosyllabic word-recognition-in-noise is more dependent on bottom-up processing than on top-down processing.The results suggest that when speech-in-noise testing is used in a pre- and post-hearing-aid-fitting format, the use of monosyllabic words may be sensitive to changes in audibility resulting from amplification. JF - Journal of the American Academy of Audiology AU - McArdle, Rachel AU - Wilson, Richard H AD - Bay Pines VA Healthcare System, Bay Pines, FL 33744, USA. Rachel.mcardle@va.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 507 EP - 518 VL - 19 IS - 6 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Female KW - Humans KW - Male KW - Noise KW - *Perceptual Masking KW - *Phonetics KW - Psychometrics KW - Reference Values KW - *Semantics KW - Sound Spectrography KW - *Speech Acoustics KW - *Speech Discrimination Tests: statistics & numerical data KW - *Speech Reception Threshold Test: statistics & numerical data KW - Young Adult UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85381566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Predicting+word-recognition+performance+in+noise+by+young+listeners+with+normal+hearing+using+acoustic%2C+phonetic%2C+and+lexical+variables.&rft.au=McArdle%2C+Rachel%3BWilson%2C+Richard+H&rft.aulast=McArdle&rft.aufirst=Rachel&rft.date=2008-06-01&rft.volume=19&rft.issue=6&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: J Am Acad Audiol. 2008 Jun;19(6):460[19253778] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Enjoyment of music by elderly hearing-impaired listeners. AN - 85378663; pmid-19253784 AB - Anecdotal evidence suggests that hearing loss interferes with the enjoyment of music, although it is not known how widespread this problem currently is.To estimate the prevalence of music-listening difficulties among a group of elderly hearing aid wearers.Interview. Telephone interviews were conducted with patients who wore hearing aids. Questions regarding several aspects of music listening were included.Sixty-eight hearing-impaired people served as subjects. They had all been seen in the audiology clinic for hearing aid evaluation during the previous year.Subjects were asked questions concerning their use of hearing aids, the importance of listening to music in their lives, their habits and practices concerning music, and difficulties they experienced in listening to music.Almost 30% of the respondents reported that their hearing losses affected their enjoyment of music. About half of the respondents indicated that music was either too loud or too soft, although only about one-third reported difficulties with level contrasts within musical pieces. In contrast to a similar survey carried out 20 years ago, there were many fewer complaints about listening to music. This result may be due in large part to improvements in hearing aids, especially with regard to nonlinear compression.Although new hearing aid technologies have somewhat reduced problems of music enjoyment experienced by hearing-impaired people, audiologists should be aware that some 25-30% of patients may have difficulties with listening to music and may require extra attention to minimize those problems. JF - Journal of the American Academy of Audiology AU - Leek, Marjorie R AU - Molis, Michelle R AU - Kubli, Lina R AU - Tufts, Jennifer B AD - Army Audiology and Speech Center, Walter Reed Army Medical Center, Washington, DC, USA. Marjorie.Leek@va.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 519 EP - 526 VL - 19 IS - 6 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - Auditory Threshold KW - Female KW - *Hearing Aids: psychology KW - Humans KW - Interviews as Topic KW - Loudness Perception KW - Male KW - Middle Aged KW - *Music KW - Patient Satisfaction KW - Perceptual Distortion KW - Pitch Discrimination KW - *Presbycusis: psychology KW - *Presbycusis: rehabilitation KW - Prosthesis Design KW - *Signal Processing, Computer-Assisted KW - Software KW - Sound Spectrography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85378663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Enjoyment+of+music+by+elderly+hearing-impaired+listeners.&rft.au=Leek%2C+Marjorie+R%3BMolis%2C+Michelle+R%3BKubli%2C+Lina+R%3BTufts%2C+Jennifer+B&rft.aulast=Leek&rft.aufirst=Marjorie&rft.date=2008-06-01&rft.volume=19&rft.issue=6&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - A comparison of recognition performances in speech-spectrum noise by listeners with normal hearing on PB-50, CID W-22, NU-6, W-1 spondaic words, and monosyllabic digits spoken by the same speaker. AN - 85377838; pmid-19253782 AB - So that portions of the classic Miller, Heise, and Lichten (1951) study could be replicated, new recorded versions of the words and digits were made because none of the three common monosyllabic word lists (PAL PB-50, CID W-22, and NU-6) contained the 9 monosyllabic digits (1-10, excluding 7) that were used by Miller et al. It is well established that different psychometric characteristics have been observed for different lists and even for the same materials spoken by different speakers. The decision was made to record four lists of each of the three monosyllabic word sets, the monosyllabic digits not included in the three sets of word lists, and the CID W-1 spondaic words. A professional female speaker with a General American dialect recorded the materials during four recording sessions within a 2-week interval. The recording order of the 582 words was random.To determine-on listeners with normal hearing-the psychometric properties materials presented in speech-spectrum noise.A quasi-experimental, repeated-measures design was used.Twenty-four young adult listeners (M = 23 years) with normal pure-tone thresholds (< or = 20-dB HL at 250 to 8000 Hz) participated. The participants were university students who were unfamiliar with the test materials.The 582 words were presented at four signal-to-noise ratios (SNRs; -7-, -2-, 3-, and 8-dB) in speech-spectrum noise fixed at 72-dB SPL. Although the main metric of interest was the 50% point on the function for each word established with the Spearman-Kärber equation (Finney, 1952), the percentage correct on each word at each SNR was evaluated. The psychometric characteristics of the PB-50, CID W-22, and NU-6 monosyllabic word lists were compared with one another, with the CID W-1 spondaic words, and with the 9 monosyllabic digits.Recognition performance on the four lists within each of the three monosyllabic word materials were equivalent, +/- 0.4 dB. Likewise, word-recognition performance on the PB-50, W-22, and NU-6 word lists were equivalent, +/- 0.2 dB. The mean recognition performance at the 50% point with the 36 W-1 spondaic words was approximately 6.2 dB lower than the 50% point with the monosyllabic words. Recognition performance on the monosyllabic digits was 1-2 dB better than mean performance on the monosyllabic words.Word-recognition performances on the three sets of materials (PB-50, CID W-22, and NU-6) were equivalent, as were the performances on the four lists that make up each of the three materials. Phonetic/phonemic balance does not appear to be an important consideration in the compilation of word-recognition lists used to evaluate the ability of listeners to understand speech. A companion paper examines the acoustic, phonetic/phonological, and lexical variables that may predict the relative ease or difficulty for which these monosyllable words were recognized in noise (McArdle and Wilson, this issue). JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AU - McArdle, Rachel AU - Roberts, Heidi AD - VA Medical Center, Mountain Home, TN 37684, USA. RICHARD.WILSON2@VA.GOV Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 496 EP - 506 VL - 19 IS - 6 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Audiometry, Pure-Tone KW - Female KW - Humans KW - Male KW - Noise KW - *Perceptual Masking KW - Phonetics KW - Psychometrics KW - Reference Values KW - *Semantics KW - Sound Spectrography KW - Speech Acoustics KW - *Speech Discrimination Tests: statistics & numerical data KW - *Speech Reception Threshold Test: statistics & numerical data KW - Young Adult UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85377838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=A+comparison+of+recognition+performances+in+speech-spectrum+noise+by+listeners+with+normal+hearing+on+PB-50%2C+CID+W-22%2C+NU-6%2C+W-1+spondaic+words%2C+and+monosyllabic+digits+spoken+by+the+same+speaker.&rft.au=Wilson%2C+Richard+H%3BMcArdle%2C+Rachel%3BRoberts%2C+Heidi&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2008-06-01&rft.volume=19&rft.issue=6&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: J Am Acad Audiol. 2008 Jun;19(6):460[19253778] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Endoscopic removal of juvenile nasopharyngeal angiofibromas: a video presentation. AN - 742774886; pmid-18391769 AB - OBJECTIVES/HYPOTHESIS: Juvenile nasal angiogibroma (JNA) is a relatively rare, benign neoplasm generally seen in prepubertal and adolescent males. In the past, surgical management included lateral rhinotomy, transpalatal and transmaxillary routes, and midface degloving approaches. Endoscopic approaches have become the treatment of choice, especially for tumors limited by size and location criteria. Our presentation demonstrates an endoscopic approach to excision of JNAs that are limited to the nasal cavity, nasopharynx, and paranasal sinuses. Through the use of a brief video presentation, participants will be able to visualize the endoscopic technique. STUDY DESIGN AND METHODS: A retrospective review of JNA patients treated at our institution identified 3 patients who underwent endoscopic removal. All patients underwent preoperative embolization followed by endoscopic resection. RESULTS: A video demonstration is presented of a patient with a 3.5 cm JNA who underwent successful endoscopic, endonasal excision. After medialization of the middle turbinate and anterior ethmoidectomy, the tumor could be mobilized using a Cottle elevator and microdebrider. The origin and attachment of the tumor were visualized and detached from the sphenopalatine foramen. The tumor was resected en bloc with minimal bleeding. There were no intraoperative complications, and postoperative bleeding was negligible. To date, there has been no evidence of recurrence of tumor in these individuals. CONCLUSIONS: Endoscopic removal is the approach of choice for small to medium, limited-extent JNAs. JF - The Laryngoscope AU - Joo, Daekeun AU - Chhetri, Dinesh K AU - Wang, Marilene B AD - Department of Surgery, Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Veterans Administration Medical Center, Los Angeles, California 90095, USA. Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - e1 EP - e3 VL - 118 IS - 6 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Video Recording KW - Humans KW - Retrospective Studies KW - Adolescent KW - Male KW - Nasal Cavity KW - Nose Neoplasms -- surgery KW - Endoscopy -- methods KW - Angiofibroma -- surgery KW - Nasopharyngeal Neoplasms -- surgery KW - Paranasal Sinus Neoplasms -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742774886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Endoscopic+removal+of+juvenile+nasopharyngeal+angiofibromas%3A+a+video+presentation.&rft.au=Joo%2C+Daekeun%3BChhetri%2C+Dinesh+K%3BWang%2C+Marilene+B&rft.aulast=Joo&rft.aufirst=Daekeun&rft.date=2008-06-01&rft.volume=118&rft.issue=6&rft.spage=e1&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Postmarketing surveillance rates of uveitis and scleritis with bisphosphonates among a national veteran cohort. AN - 71676865; 18536608 AB - Uveitis and scleritis are the most serious ocular side effects of bisphosphonate therapy. The purpose of this study was to determine the 6-month rates of uveitis/scleritis following dispensing of bisphosphonates in a large veteran cohort. Two national databases (clinical and pharmacy) for fiscal year (FY) 2006 were linked to identify new diagnoses of uveitis/scleritis following the initial dispensing of bisphosphonate drugs. New diagnoses in FY 2006 were identified using International Classification of Diseases, Version 9, Clinical Modification (ICD-9-CM), in a cohort of veterans without a previous diagnosis of uveitis or scleritis using a look-back period to FY 2005. The new diagnoses were temporally aligned with initial dispensing of bisphosphonates and the rates of new cases were calculated for 1-month and 6-month time intervals. There were 7.9 new cases of uveitis/scleritis per 10,000 individuals with a newly dispensed bisphosphonate that occurred within 180 days. The relative risk of uveitis/scleritis for 6 months was 1.23 (95% confidence interval: 0.85-1.79) compared to veterans not exposed to the medications. The rates of uveitis/scleritis did not differ significantly based on route of administration (oral or parenteral) or after age adjustment. Just over a third of the diagnoses were scleritis. Nearly 43% of patients with uveitis/scleritis after bisphosphonate use had a systemic diagnosis commonly associated with inflammation of the uveal tract or sclera. The 30-day and 6-month rates of uveitis/scleritis following the dispensing of a bisphosphonate drug are low and do not differ significantly from rates recorded for veterans not dispensed these drugs. JF - Retina (Philadelphia, Pa.) AU - French, Dustin D AU - Margo, Curtis E AD - VISN-8 Patient Safety Center of Inquiry, James A. Haley Hospital, Tampa, FL 33613, USA. Dustin.French@va.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 889 EP - 893 VL - 28 IS - 6 SN - 0275-004X, 0275-004X KW - Bone Density Conservation Agents KW - 0 KW - Diphosphonates KW - pamidronate KW - OYY3447OMC KW - Alendronate KW - X1J18R4W8P KW - Index Medicus KW - Administration, Oral KW - United States KW - Pharmacy Service, Hospital -- statistics & numerical data KW - Humans KW - Aged KW - Infusions, Parenteral KW - Veterans -- statistics & numerical data KW - Aged, 80 and over KW - Databases, Factual KW - Middle Aged KW - Female KW - Male KW - Drug Prescriptions -- statistics & numerical data KW - Scleritis -- epidemiology KW - Diphosphonates -- adverse effects KW - Scleritis -- diagnosis KW - Uveitis -- diagnosis KW - Scleritis -- chemically induced KW - Uveitis -- epidemiology KW - Product Surveillance, Postmarketing -- statistics & numerical data KW - Alendronate -- adverse effects KW - Uveitis -- chemically induced KW - United States Department of Veterans Affairs -- statistics & numerical data KW - Bone Density Conservation Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71676865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Retina+%28Philadelphia%2C+Pa.%29&rft.atitle=Postmarketing+surveillance+rates+of+uveitis+and+scleritis+with+bisphosphonates+among+a+national+veteran+cohort.&rft.au=French%2C+Dustin+D%3BMargo%2C+Curtis+E&rft.aulast=French&rft.aufirst=Dustin&rft.date=2008-06-01&rft.volume=28&rft.issue=6&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=Retina+%28Philadelphia%2C+Pa.%29&rft.issn=0275004X&rft_id=info:doi/10.1097%2FIAE.0b013e31816576ef LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-24 N1 - Date created - 2008-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Retina. 2009 Feb;29(2):285-6; author reply 286-7 [19202428] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/IAE.0b013e31816576ef ER - TY - JOUR T1 - The anti-apoptosis protein, survivin, mediates gastric epithelial cell cytoprotection against ethanol-induced injury via activation of the p34(cdc2) cyclin-dependent kinase. AN - 70453162; 18181150 AB - The anti-apoptosis protein, survivin, promotes cell survival and mitosis. Recent studies have demonstrated that survivin is expressed in normal gastric mucosa. Using an in vitro model, we examined whether survivin plays a role in the cytoprotection produced in gastric mucosa by mild irritant ethanol (ETOH) against subsequent exposure to concentrated ETOH. Pre-treatment of rat gastric epithelial cells with 1% ETOH reduced cell death, in response to subsequent incubation with 5% ETOH, by 94% (P < 0.005). This pre-treatment also resulted in increased total and phosphorylated survivin protein levels by 180% (P < 0.0001) and 540% (P < 0.0002), respectively, which required the p34(cdc2) cell cycle-dependent kinase. The cytoprotective effect was abrogated upon siRNA knockdown of survivin protein levels. Further, overexpression of exogenous survivin resulted in significant cytoprotection by 62% (P < 0.02) in the absence of any pre-treatment. We further examined the in vivo relevance of these findings. In fasted rats, administration of 20% ETOH, which we found to be 93% (P < 0.0001) cytoprotective against 50% ETOH challenge, resulted in increased total and phosphorylated survivin protein levels by 234% (P < 0.001) and 214% (P < 0.02), respectively. Administration of 20% ETOH resulted in increased gastric p34(cdc2) activity by 146% (P < 0.01). Inhibition of p34(cdc2) by the potent inhibitor, roscovitine, abolished the increased survivin levels in response to pre-administration of 20% ETOH and reduced the cytoprotection against 50% ETOH challenge by 59% (P < 0.01). These results indicate that survivin is a key mediator of cytoprotection against ETOH-induced gastric injury, acting at the epithelial cell level, by a mechanism that is dependent, in part, on p34(cdc2). (c) 2008 Wiley-Liss, Inc. JF - Journal of cellular physiology AU - Jones, Michael K AU - Padilla, Oscar R AU - Webb, Nicole A AU - Norng, Manith AD - Research, Veterans Affairs Long Beach Healthcare System, Long Beach, California 90822, USA. michael.jones4@med.va.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 750 EP - 764 VL - 215 IS - 3 KW - Birc5 protein, rat KW - 0 KW - Microtubule-Associated Proteins KW - Phosphoproteins KW - RNA, Messenger KW - Threonine KW - 2ZD004190S KW - Ethanol KW - 3K9958V90M KW - CDC2 Protein Kinase KW - EC 2.7.11.22 KW - Index Medicus KW - Animals KW - RNA, Messenger -- genetics KW - Gastric Mucosa -- pathology KW - Rats KW - Protein Biosynthesis -- drug effects KW - Gastric Mucosa -- enzymology KW - Rats, Sprague-Dawley KW - RNA, Messenger -- metabolism KW - Enzyme Activation -- drug effects KW - Gastric Mucosa -- drug effects KW - Male KW - Phosphoproteins -- metabolism KW - Microtubule-Associated Proteins -- metabolism KW - CDC2 Protein Kinase -- antagonists & inhibitors KW - CDC2 Protein Kinase -- metabolism KW - Ethanol -- administration & dosage KW - Stomach -- cytology KW - Stomach -- pathology KW - Epithelial Cells -- cytology KW - Epithelial Cells -- drug effects KW - Epithelial Cells -- enzymology KW - Epithelial Cells -- pathology KW - Apoptosis -- drug effects KW - Ethanol -- toxicity KW - Cytoprotection -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70453162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=The+anti-apoptosis+protein%2C+survivin%2C+mediates+gastric+epithelial+cell+cytoprotection+against+ethanol-induced+injury+via+activation+of+the+p34%28cdc2%29+cyclin-dependent+kinase.&rft.au=Jones%2C+Michael+K%3BPadilla%2C+Oscar+R%3BWebb%2C+Nicole+A%3BNorng%2C+Manith&rft.aulast=Jones&rft.aufirst=Michael&rft.date=2008-06-01&rft.volume=215&rft.issue=3&rft.spage=750&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=1097-4652&rft_id=info:doi/10.1002%2Fjcp.21358 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-29 N1 - Date created - 2008-04-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Pathol. 2000 Feb;156(2):393-8 [10666367] Digestion. 1996;57(1):54-9 [8626049] Biochem J. 2000 Jul 15;349(Pt 2):489-99 [10880348] Hum Pathol. 2001 Jan;32(1):119-25 [11172305] Blood. 2001 Oct 1;98(7):2091-100 [11567995] J Physiol Paris. 2001 Jan-Dec;95(1-6):3-9 [11595412] Hum Immunol. 2002 Feb;63(2):101-7 [11821157] Aliment Pharmacol Ther. 2002 Apr;16 Suppl 2:74-82 [11966527] Cancer Cell. 2002 Jul;2(1):43-54 [12150824] Biochem Biophys Res Commun. 2002 Sep 13;297(1):59-64 [12220508] Eur J Biochem. 1997 Jan 15;243(1-2):518-26 [9030780] Oncogene. 1997 Sep 4;15(10):1143-9 [9294607] J Clin Invest. 1997 Nov 15;100(10):2512-20 [9366565] Dig Dis Sci. 1998 Apr;43(4):806-15 [9558038] J Med Invest. 1998 Feb;44(3-4):137-47 [9597801] Dig Dis Sci. 1998 Jun;43(6):1248-57 [9635615] Ann Surg. 1998 Jul;228(1):123-30 [9671076] Science. 1998 Jul 24;281(5376):533-8 [9677190] Am J Physiol. 1998 Aug;275(2 Pt 1):G322-30 [9688660] J Biol Chem. 1999 Mar 19;274(12):7958-68 [10075693] Gastroenterology. 2005 Jan;128(1):63-73 [15633124] Curr Med Chem. 2005;12(2):203-15 [15638736] Br J Cancer. 2005 Jan 31;92(2):212-6 [15611788] J Vasc Surg. 2005 Apr;41(4):682-90 [15874934] J Physiol Pharmacol. 2005 Sep;56 Suppl 5:33-55 [16247188] Int Rev Cytol. 2005;247:35-88 [16344111] Trends Cardiovasc Med. 2006 May;16(4):114-7 [16713533] Curr Opin Cell Biol. 2006 Dec;18(6):616-22 [16962308] Cell Cycle. 2007 May 15;6(10):1220-30 [17457057] Mol Cell Biol. 2002 Oct;22(20):7226-41 [12242299] Bioorg Med Chem Lett. 2002 Nov 18;12(22):3283-6 [12392733] Med Sci Monit. 2003 Apr;9(4):PI25-9 [12709681] Biochem Biophys Res Commun. 2003 May 30;305(2):374-9 [12745085] EMBO J. 2003 Jun 2;22(11):2729-40 [12773388] Hepatology. 2003 Aug;38(2):385-93 [12883482] Oncogene. 2003 Aug 14;22(34):5281-90 [12917629] Exp Biol Med (Maywood). 2003 Oct;228(9):1089-95 [14530521] Dig Dis Sci. 2004 Feb;49(2):210-7 [15104359] Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13239-44 [15329416] DNA Cell Biol. 2004 Sep;23(9):527-37 [15383173] Biochim Biophys Acta. 1976 Jul 21;437(2):354-63 [1085166] Am J Physiol. 1983 Jul;245(1):G113-21 [6869543] Am J Med. 1985 Aug 30;79(2C):19-23 [2863980] Gastroenterology. 1988 Apr;94(4):948-54 [3162219] Dig Dis Sci. 1989 Mar;34(3):429-35 [2920649] Prostaglandins. 1991 Mar;41(3):207-23 [1906621] EMBO J. 1991 Nov;10(11):3321-9 [1655417] Histol Histopathol. 1989 Jan;4(1):105-15 [2520443] Mol Cell Biol. 1993 Mar;13(3):1675-85 [8441405] Dig Dis Sci. 1995 Apr;40(4):872-8 [7720484] Aliment Pharmacol Ther. 1995 Jun;9(3):227-35 [7654885] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13103-7 [11069302] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jcp.21358 ER - TY - JOUR T1 - Paternal environmental exposures and gene expression during spermatogenesis: research review to research framework. AN - 69247539; 18546338 AB - The primary objective is to review Dioxin toxicity, the potential impact on spermatogenesis, what is known and unknown about paternal exposures, and the potential mechanisms whereby paternal preconception exposures result in neural tube defects (NTD). The secondary goal is to suggest a versatile research framework utilizing gene expression microarray to evaluate the impact of acute, intermittent, and chronic paternal exposures to environmental agents on gene expression during the stages of spermatogenesis. There are multiple barriers to establishing a paradigm whereby paternal environmental exposures result in adverse birth outcomes. Microarray expression studies are unique in their ability to detect transcription dysregulation, thereby facilitating the identification of molecular and developmental pathways through hierarchical and pathway analysis. To date there are no studies of gene expression during spermatogenesis following exposure to environmental agents. JF - Birth defects research. Part C, Embryo today : reviews AU - Hansen, Deborah A AD - Department of Veterans Affairs, Veterans Health Administration, St. Louis, Missouri, USA. d.hansen@att.net Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 155 EP - 163 VL - 84 IS - 2 KW - Dioxins KW - 0 KW - Index Medicus KW - Veterans KW - Rats KW - Animals KW - Gulf War KW - Humans KW - Testis -- pathology KW - Vietnam Conflict KW - Infant, Newborn KW - Research -- trends KW - Male KW - Radionuclide Imaging KW - Spermatogenesis -- physiology KW - Congenital Abnormalities -- diagnostic imaging KW - Paternal Exposure -- adverse effects KW - Gene Expression KW - Congenital Abnormalities -- epidemiology KW - Congenital Abnormalities -- etiology KW - Environmental Exposure -- adverse effects KW - Dioxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69247539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+C%2C+Embryo+today+%3A+reviews&rft.atitle=Paternal+environmental+exposures+and+gene+expression+during+spermatogenesis%3A+research+review+to+research+framework.&rft.au=Hansen%2C+Deborah+A&rft.aulast=Hansen&rft.aufirst=Deborah&rft.date=2008-06-01&rft.volume=84&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+C%2C+Embryo+today+%3A+reviews&rft.issn=1542-9768&rft_id=info:doi/10.1002%2Fbdrc.20121 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-06 N1 - Date created - 2008-06-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/bdrc.20121 ER - TY - JOUR T1 - Program Evaluation for Organizational Cultural Competence in Mental Health Practices AN - 57281746; 200917474 AB - Mental health practices that lack cultural competence prevent diverse clients from receiving the care they deserve. As providers and program administrators, psychologists currently have a responsibility to ensure high quality of care for diverse clients at the clinic level. This article deciphers extant empirical research, organizational theory, public policy literature, and best practices to identify which recommendations are most relevant for those in small mental health practices and clinics. The authors present 10 components for culturally appropriate care, ranging from policies and procedures to needs and satisfaction level of clients. This overview can be used to help evaluate and develop a mental health practice's ability to meet the needs of diverse clients. [Copyright Elsevier B.V.] JF - Professional Psychology: Research and Practice AU - Whealin, Julia M AU - Ruzek, Josef AD - Veterans Affairs Pacific Islands Health Care System julia.whealin@va.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 320 EP - 328 PB - American Psychological Association, Washington DC VL - 39 IS - 3 SN - 0735-7028, 0735-7028 KW - culture program evaluation multicultural competence organization practice KW - Client satisfaction KW - Mental health services KW - Clinics KW - Service provision KW - Diversity KW - Cultural competence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Psychology%3A+Research+and+Practice&rft.atitle=Program+Evaluation+for+Organizational+Cultural+Competence+in+Mental+Health+Practices&rft.au=Whealin%2C+Julia+M%3BRuzek%2C+Josef&rft.aulast=Whealin&rft.aufirst=Julia&rft.date=2008-06-01&rft.volume=39&rft.issue=3&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Professional+Psychology%3A+Research+and+Practice&rft.issn=07357028&rft_id=info:doi/10.1037%2F0735-7028.39.3.320 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Mental health services; Clinics; Cultural competence; Service provision; Diversity; Client satisfaction DO - http://dx.doi.org/10.1037/0735-7028.39.3.320 ER - TY - JOUR T1 - Discriminative delay Pavlovian eyeblink conditioning in veterans with and without posttraumatic stress disorder AN - 57275772; 200906168 AB - Background Impaired eyeblink (EB) classical conditioning using a delay paradigm has previously been shown in combat veterans, as well as in a group of depressed adults, compared to normal individuals. Significant deficits in immediate memory (IM) in combat PTSD+ veterans, compared to normal controls, have also been previously shown, but these differences became non-significant after controlling for level of self-reported depression. Furthermore, EB conditioning has been shown to be significantly correlated with heart rate variability (HRV) in normal adults. The present study examined how depression (self-reported), IM, and resting HRV are related to discriminative delay classical EB conditioning in veterans with and without PTSD. Method Three groups of subjects (combat PTSD+, combat PTSD-, and non-combat PTSD-) were assessed for self-report of depression and anxiety, as well as IM and HRV. Subjects received a single session of discriminative EB classical conditioning in which the conditioned stimulus (CS) was a light signal (either red or green) compounded with a tone. On CS+ trials, the light-tone compound stimulus co-terminated with a corneal airpuff (unconditioned stimulus, US), thus producing a delay paradigm. On CS- trials the appropriate light-tone stimulus was presented but not followed by the airpuff US. EB amplitude and frequency were recorded. Results PTSD+ subjects had greater self-reported depression and anxiety scores than the two control groups, as well as lower scores on a measure of IM. However, the IM difference was not significant after the effects of self-reported depression and anxiety were controlled. EB CR amplitude was significantly greater to CS+ than CS- for all three groups. EB amplitude to both the US (airpuff) and the CS+ declined over trials, but was significantly lower in the combat PTSD+ group compared to the combined PTSD- groups. Subjects who reached an EB CR acquisition criterion had significantly greater scores on IM than those who did not reach criterion. Factor analysis of the entire data set revealed four factors corresponding to (1) self-reported depression and anxiety, (2) IM, (3) HRV, and (4) EB amplitude. EB frequency was significantly predicted by IM and HRV. Conclusions These data extend our previous results by showing deficits in EB conditioning among combat PTSD+ veterans that were associated with lower IM and resting HRV, but were not associated with self-report of depression. [Copyright Elsevier B.V.] JF - Journal of Anxiety Disorders AU - Ginsberg, J P AU - Ayers, Edwin AU - Burriss, Louisa AU - Powell, D A AD - Dorn VA Medical Center, Columbia, SC 29209-1639, United States Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 809 EP - 823 PB - Elsevier Ltd, The Netherlands VL - 22 IS - 5 SN - 0887-6185, 0887-6185 KW - Classical conditioning Anxiety Depression Cognitive assessments Learning Memory KW - Veterans KW - Posttraumatic stress disorder KW - Conditioning KW - Stimulus KW - Anxiety-Depression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57275772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Anxiety+Disorders&rft.atitle=Discriminative+delay+Pavlovian+eyeblink+conditioning+in+veterans+with+and+without+posttraumatic+stress+disorder&rft.au=Ginsberg%2C+J+P%3BAyers%2C+Edwin%3BBurriss%2C+Louisa%3BPowell%2C+D+A&rft.aulast=Ginsberg&rft.aufirst=J&rft.date=2008-06-01&rft.volume=22&rft.issue=5&rft.spage=809&rft.isbn=&rft.btitle=&rft.title=Journal+of+Anxiety+Disorders&rft.issn=08876185&rft_id=info:doi/10.1016%2Fj.janxdis.2007.08.009 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Anxiety-Depression; Veterans; Conditioning; Stimulus; Posttraumatic stress disorder DO - http://dx.doi.org/10.1016/j.janxdis.2007.08.009 ER - TY - JOUR T1 - A Randomized Control Trial Examining the Effect of Acceptance and Commitment Training on Clinician Willingness to Use Evidence-Based Pharmacotherapy AN - 57253956; 200816696 AB - This study evaluated the effectiveness of acceptance and commitment training (ACT) for increasing drug and alcohol counselors' willingness to use evidence-based agonist and antagonist pharmacotherapy. Fifty-nine drug and alcohol counselors were randomly assigned to either a 1-day ACT workshop or a 1-day educational control workshop. Both groups then attended a 2-day workshop on empirically supported treatments for substance abuse. Measures were taken at pre- and posttraining and 3-month follow-up on reported use of pharmacotherapy, willingness to use pharmacotherapy, perceived barriers to implementing new treatments, and general acceptance. As compared with those in the education alone condition, participants in the ACT condition showed significantly higher rates of referrals to pharmacotherapy at follow-up, rated barriers to learning new treatments as less believable at posttraining and follow-up, and showed greater psychological flexibility at posttraining and follow-up. Mediational analyses indicated that reduced believability of barriers and greater psychological flexibility mediated the impact of the intervention. Results support the idea that acceptance-based interventions may be helpful in addressing the psychological factors related to poor adoption of evidence-based treatments. [Copyright 2008 American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Varra, Alethea A AU - Hayes, Steven C AU - Roget, Nancy AU - Fisher, Gary AD - Veterans Affairs Puget Sound Healthcare System, Mental Health Service (116), 1660 S. Columbian Way, Seattle, WA 98108 alethea.varra@va.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 449 EP - 458 PB - American Psychological Association, Washington DC VL - 76 IS - 3 SN - 0022-006X, 0022-006X KW - dissemination, pharmacotherapy, substance abuse, acceptance and commitment therapy KW - Evidence based KW - Acceptance KW - Flexibility KW - Therapy KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57253956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=A+Randomized+Control+Trial+Examining+the+Effect+of+Acceptance+and+Commitment+Training+on+Clinician+Willingness+to+Use+Evidence-Based+Pharmacotherapy&rft.au=Varra%2C+Alethea+A%3BHayes%2C+Steven+C%3BRoget%2C+Nancy%3BFisher%2C+Gary&rft.aulast=Varra&rft.aufirst=Alethea&rft.date=2008-06-01&rft.volume=76&rft.issue=3&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2F0022-006X.76.3.449 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Therapy; Acceptance; Flexibility; Evidence based; Substance abuse DO - http://dx.doi.org/10.1037/0022-006X.76.3.449 ER - TY - JOUR T1 - Clinical Outcomes of Integrated Psychiatric and General Medical Care AN - 57252891; 200822718 AB - This pilot study explored the feasibility of providing integrated primary and psychiatric care in a primary care setting and compared preliminary outcomes to those from a traditional care model. The study population consisted of 23 patients who received integrated medical and psychiatric care in a primary care clinic and 23 comparison patients who received medical care in a primary care clinic and psychiatric care in a separate mental health clinic. This study suggests that integrated care can be provided to chronically mentally ill patients in a primary care setting and generate outcomes comparable to those of standard care. Adapted from the source document. JF - Community Mental Health Journal AU - Snyder, Kristen AU - Dobscha, Steven K AU - Ganzini, Linda AU - Hoffman, William F AU - Delorit, Molly A AD - Department of Veterans Affairs, Veterans Health Administration, Mental Health Division, Acute Psychiatry, Portland, OR, USA snyderk@ohsu.edu Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 147 EP - 154 PB - Springer, Dordrecht The Netherlands VL - 44 IS - 3 SN - 0010-3853, 0010-3853 KW - Chronically KW - Mentally ill people KW - Mental health services KW - Integrated services KW - Primary health care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57252891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Clinical+Outcomes+of+Integrated+Psychiatric+and+General+Medical+Care&rft.au=Snyder%2C+Kristen%3BDobscha%2C+Steven+K%3BGanzini%2C+Linda%3BHoffman%2C+William+F%3BDelorit%2C+Molly+A&rft.aulast=Snyder&rft.aufirst=Kristen&rft.date=2008-06-01&rft.volume=44&rft.issue=3&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-007-9117-4 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - CMHJAY N1 - SubjectsTermNotLitGenreText - Primary health care; Integrated services; Mentally ill people; Chronically; Mental health services DO - http://dx.doi.org/10.1007/s10597-007-9117-4 ER - TY - JOUR T1 - A Spiritually Based Group Intervention for Combat Veterans With Posttraumatic Stress Disorder: Feasibility Study AN - 57248912; 200816962 AB - Purpose: To assess the feasibility, effect sizes, and satisfaction of mantram repetition -- the spiritual practice of repeating a sacred word/phrase throughout the day -- for managing symptoms of posttraumatic stress disorder (PTSD) in veterans. Design: A two group (intervention vs. control) by two time (pre- and postintervention) experimental design was used. Methods: Veterans were randomly assigned to intervention (n = 14) or delayed-treatment control (n = 15). Measures were PTSD symptoms, psychological distress, quality of life, and patient satisfaction. Effect sizes were calculated using Cohen's d. Findings: Thirty-three male veterans were enrolled, and 29 (88%) completed the study. Large effect sizes were found for reducing PTSD symptom severity (d = -.72), psychological distress (d = -.73) and increasing quality of life (d = -.70). Conclusions: A spiritual program was found to be feasible for veterans with PTSD. They reported moderate to high satisfaction. Effect sizes show promise for symptom improvement but more research is needed. [Copyright 2008 Sage Publications, Inc.] JF - Journal of Holistic Nursing AU - Bormann, Jill E AU - Thorp, Steven AU - Wetherell, Julie L AU - Golshan, Shahrokh AD - VA San Diego Healthcare System and San Diego State University jill.bormann@va.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 109 EP - 116 PB - Sage Publications VL - 26 IS - 2 SN - 0898-0101, 0898-0101 KW - posttraumatic stress disorder veterans spirituality quality of life mindfulness intervention meditation mind-body relaxation KW - Veterans KW - Feasibility KW - Posttraumatic stress disorder KW - Psychological distress KW - Quality of life KW - Effect size KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57248912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Holistic+Nursing&rft.atitle=A+Spiritually+Based+Group+Intervention+for+Combat+Veterans+With+Posttraumatic+Stress+Disorder%3A+Feasibility+Study&rft.au=Bormann%2C+Jill+E%3BThorp%2C+Steven%3BWetherell%2C+Julie+L%3BGolshan%2C+Shahrokh&rft.aulast=Bormann&rft.aufirst=Jill&rft.date=2008-06-01&rft.volume=26&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Journal+of+Holistic+Nursing&rft.issn=08980101&rft_id=info:doi/10.1177%2F0898010107311276 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JHNUF8 N1 - SubjectsTermNotLitGenreText - Veterans; Posttraumatic stress disorder; Effect size; Quality of life; Feasibility; Psychological distress DO - http://dx.doi.org/10.1177/0898010107311276 ER - TY - JOUR T1 - Endoscopic Reflectance Spectrophotometry and Visible Light Spectroscopy in Clinical Gastrointestinal Studies AN - 20824168; 8319544 AB - The use of reflectance spectrophotometry (RS) for mucosal hemodynamic measurement relies on the recognition of changes in indexes of mucosal hemoglobin concentration and oxygen saturation. Endoscopic application in clinical studies has confirmed important observations demonstrated in animal experiments. The vasoconstriction induced by propranolol, vasopressin, glypressin, or somatostatin in the portal hypertensive gastric mucosa and the reduction of gastroduodenal mucosal perfusion by nonsteroidal anti-inflammatory drugs (NSAIDs) or smoking, mesenteric venoconstriction associated with systemic hypoxia, and acid-induced duodenal hyperemia are important examples. Prognostic predictions include the development of stress-induced gastric ulcerations in patients with significant reductions in gastric perfusion after thermal or head injury, or the demonstration of delayed gastric or duodenal ulcer healing when the hyperemia at the ulcer margin fails to materialize. In mechanical-ventilator-dependent patients with sepsis, a significantly reduced gastric mucosal RS measurement portends a grave prognosis (mortality > 80%). Recent advances in technology resulted in the construction and validation of instruments for visible light spectroscopy. Measurements focused on tissue oxygen saturation demonstrated epinephrine and vessel-ligation-induced vasoconstriction, the absence of ischemia in radiation-induced rectal telangiectasias, and gut ischemia responsive to revascularization treatment. Endoscopic RS and visible light spectroscopy are suitable for assessing the role of blood flow in conditions with a lesser degree of ischemia and for testing the hypothesis that functional dyspepsia and dysmotility syndromes may be due to gut ischemia. JF - Digestive Diseases and Sciences AU - Leung, Felix W AD - VA Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA, 91343, USA, felix.leung@va.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1669 EP - 1677 PB - Springer New York, LLC, 233 Spring St New York NY 10013-1578 USA VL - 53 IS - 6 SN - 0163-2116, 0163-2116 KW - Microbiology Abstracts B: Bacteriology KW - Rectum KW - Reflectance KW - Gastric mucosa KW - Injuries KW - Hemodynamics KW - Spectroscopy KW - Hemoglobin KW - Smoking KW - Propranolol KW - Spectrophotometry KW - Epinephrine KW - Mortality KW - Perfusion KW - Head KW - Prognosis KW - Vasoconstriction KW - Ischemia KW - hyperemia KW - Somatostatin KW - Light effects KW - Oxygen KW - dyspepsia KW - Sepsis KW - Digestive tract KW - Vasopressin KW - Ulcers KW - Hypoxia KW - Nonsteroidal antiinflammatory drugs KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20824168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+Diseases+and+Sciences&rft.atitle=Endoscopic+Reflectance+Spectrophotometry+and+Visible+Light+Spectroscopy+in+Clinical+Gastrointestinal+Studies&rft.au=Leung%2C+Felix+W&rft.aulast=Leung&rft.aufirst=Felix&rft.date=2008-06-01&rft.volume=53&rft.issue=6&rft.spage=1669&rft.isbn=&rft.btitle=&rft.title=Digestive+Diseases+and+Sciences&rft.issn=01632116&rft_id=info:doi/10.1007%2Fs10620-007-0026-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gastric mucosa; Reflectance; Rectum; Injuries; Hemodynamics; Spectroscopy; Hemoglobin; Smoking; Propranolol; Spectrophotometry; Epinephrine; Mortality; Perfusion; Head; Prognosis; Vasoconstriction; Ischemia; hyperemia; Somatostatin; Light effects; Oxygen; Sepsis; dyspepsia; Digestive tract; Vasopressin; Ulcers; Hypoxia; Nonsteroidal antiinflammatory drugs DO - http://dx.doi.org/10.1007/s10620-007-0026-8 ER - TY - JOUR T1 - Carvedilol Versus Controlled-Release Metoprolol for Elderly Veterans with Heart Failure AN - 19473982; 8386774 AB - OBJECTIVESTo characterize prescribing of carvedilol and controlled-release (CR) metoprolol for veterans with heart failure who were predominantly elderly (aged greater than or equal to 65) and to compare the time to first hospitalization or death. DESIGNRetrospective cohort. SETTINGVeterans Health Administration (VHA) nationwide healthcare system. SUBJECTSVeterans enrolled in fee-for-service Medicare that had a VHA diagnosis of heart failure and a first prescription for carvedilol (n=17,429) or CR metoprolol (n=8,683) between October 1999 and September 2003. MEASUREMENTSPrescribed daily doses and CR metoprolol-to-carvedilol hazard ratios (HRs) estimated using Cox regression within strata defined according to propensity to prescribe carvedilol. RESULTSAfter several months, the majority of prescribed doses in both cohorts were less than 50% of target doses. The risk-adjusted HR was 0.99 (95% confidence interval=0.96-1.03) for hospitalization or death and 0.91 (0.85-0.96) for death alone. CONCLUSIONDoses of beta-blockers being prescribed to predominantly elderly veterans with heart failure were much lower than proven doses. Whether efforts to increase doses can improve the effectiveness of beta-blocker therapy warrants further study. At the prescribed doses, CR metoprolol was associated with better survival than carvedilol, although unmeasured confounding variables might explain the observed difference in survival. JF - Journal of the American Geriatrics Society AU - Rector, Thomas S AU - Anand, Inder S AU - Nelson, David B AU - Ensrud, Kristine E AD - Minneapolis Veterans Affairs Medical Center and Department of Medicine, University of Minnesota, Minneapolis, Minnesota., thomas.rector@va.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1021 EP - 1027 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 56 IS - 6 SN - 0002-8614, 0002-8614 KW - Biotechnology and Bioengineering Abstracts KW - heart failure KW - beta-blockers KW - effectiveness KW - Geriatrics KW - Survival KW - metoprolol KW - Controlled release KW - Heart diseases KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19473982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Carvedilol+Versus+Controlled-Release+Metoprolol+for+Elderly+Veterans+with+Heart+Failure&rft.au=Rector%2C+Thomas+S%3BAnand%2C+Inder+S%3BNelson%2C+David+B%3BEnsrud%2C+Kristine+E&rft.aulast=Rector&rft.aufirst=Thomas&rft.date=2008-06-01&rft.volume=56&rft.issue=6&rft.spage=1021&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2008.01682.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Geriatrics; Survival; metoprolol; Controlled release; Heart diseases DO - http://dx.doi.org/10.1111/j.1532-5415.2008.01682.x ER - TY - CPAPER T1 - Calf Muscle Oxygenation during Treadmill and Calf Exercise and Recovery in Peripheral Arterial Disease T2 - 55th Annual Meeting on American College of Sports Medicine AN - 40924370; 4852452 JF - 55th Annual Meeting on American College of Sports Medicine AU - Figoni, Stephen F AU - Kunkel, Charles F AU - Scremin, A M Erika AU - Scremin, Oscar U Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 KW - Oxygenation KW - Muscles KW - Physical training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40924370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.atitle=Calf+Muscle+Oxygenation+during+Treadmill+and+Calf+Exercise+and+Recovery+in+Peripheral+Arterial+Disease&rft.au=Figoni%2C+Stephen+F%3BKunkel%2C+Charles+F%3BScremin%2C+A+M+Erika%3BScremin%2C+Oscar+U&rft.aulast=Figoni&rft.aufirst=Stephen&rft.date=2008-05-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={5BED7A1E -083F-4107-A97F-8F8C1C461977}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender-Related Performance Comparison for Ultramarathon Trail Running T2 - 55th Annual Meeting on American College of Sports Medicine AN - 40922715; 4851892 JF - 55th Annual Meeting on American College of Sports Medicine AU - Hoffman, Martin D Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 KW - Running KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40922715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.atitle=Gender-Related+Performance+Comparison+for+Ultramarathon+Trail+Running&rft.au=Hoffman%2C+Martin+D&rft.aulast=Hoffman&rft.aufirst=Martin&rft.date=2008-05-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={5BED7A1E -083F-4107-A97F-8F8C1C461977}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Management of FDA Device Recalls and Manufacturer Safety Advisories by the Veterans Health Administration T2 - 29th Annual Scientific Sessions of the Heart Rhythm Society (Heart Rhythm 2008) AN - 40954057; 4860233 JF - 29th Annual Scientific Sessions of the Heart Rhythm Society (Heart Rhythm 2008) AU - Keung, Edmund AU - Schmidt, Andrew AU - Roberts, Leonard AU - Duncan, William AU - Jesse, Robert Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40954057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=29th+Annual+Scientific+Sessions+of+the+Heart+Rhythm+Society+%28Heart+Rhythm+2008%29&rft.atitle=Management+of+FDA+Device+Recalls+and+Manufacturer+Safety+Advisories+by+the+Veterans+Health+Administration&rft.au=Keung%2C+Edmund%3BSchmidt%2C+Andrew%3BRoberts%2C+Leonard%3BDuncan%2C+William%3BJesse%2C+Robert&rft.aulast=Keung&rft.aufirst=Edmund&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=29th+Annual+Scientific+Sessions+of+the+Heart+Rhythm+Society+%28Heart+Rhythm+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B570DE1 7C%2D9E7D%2D4BBE%2D97E6%2DEE56B20B436D%7D&AKey=%7BB41FF5AA%2D54D0%2D 4CA8%2D8CE2%2D54F33E1D13F1%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regional Myo-Inositol Concentration in Mild Cognitive Impairment and Alzheimer Disease Using 1H Magnetic Resonance Spectroscopic Imaging T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40943024; 4854931 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Siger, Malgorzata AU - Schuff, Norbert AU - Zhu, Xiaoping AU - Weiner, Michael Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Neurodegenerative diseases KW - Imaging techniques KW - Alzheimer's disease KW - Magnetic resonance spectroscopy KW - Cognitive ability KW - Resonance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40943024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Regional+Myo-Inositol+Concentration+in+Mild+Cognitive+Impairment+and+Alzheimer+Disease+Using+1H+Magnetic+Resonance+Spectroscopic+Imaging&rft.au=Siger%2C+Malgorzata%3BSchuff%2C+Norbert%3BZhu%2C+Xiaoping%3BWeiner%2C+Michael&rft.aulast=Siger&rft.aufirst=Malgorzata&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A Preliminary Analysis of Reading Materials and Strategies Used by Older Adults AN - 85707434; 200912582 AB - The purpose of this preliminary study was to gather information related to reading abilities of typically aging older adults, the strategies that older adults use to improve reading comprehension, and the types and frequency of reading materials older adults use. Ninety-six adults, mostly college-educated volunteers between the ages of 65 and 79 years participated. The data collected indicated that this group of adults used a wide variety of materials and strategies for reading and generally were successful readers. Implications for rehabilitation professions who work with older adults are considered. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Communication Disorders Quarterly AU - Champley, Jill AU - Scherz, Julie W AU - Apel, Kenn AU - Burda, Angela N AD - VA Nebraska-Western Iowa Health System JillChampley@va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 131 EP - 140 VL - 29 IS - 3 SN - 1525-7401, 1525-7401 KW - Reading Comprehension (70750) KW - Reading Ability (70500) KW - Elderly (21350) KW - Reading Materials (71100) KW - Reading Strategies (71400) KW - Remedial Reading (72900) KW - article KW - 4119: applied linguistics; reading processes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85707434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Communication+Disorders+Quarterly&rft.atitle=A+Preliminary+Analysis+of+Reading+Materials+and+Strategies+Used+by+Older+Adults&rft.au=Champley%2C+Jill%3BScherz%2C+Julie+W%3BApel%2C+Kenn%3BBurda%2C+Angela+N&rft.aulast=Champley&rft.aufirst=Jill&rft.date=2008-05-01&rft.volume=29&rft.issue=3&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Communication+Disorders+Quarterly&rft.issn=15257401&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2009-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Reading Strategies (71400); Reading Materials (71100); Elderly (21350); Reading Ability (70500); Reading Comprehension (70750); Remedial Reading (72900) ER - TY - JOUR T1 - A Componential Analysis of Proverb Interpretation in Patients with Frontal Lobe Epilepsy and Temporal Lobe Epilepsy: Relationships with Disease-Related Factors AN - 85698385; 200812311 AB - The ability to interpret nonliteral, metaphoric language was explored in patients with frontal lobe epilepsy (FLE) and temporal lobe epilepsy (TLE), and matched control participants, to determine (1) if patients with FLE were impaired in their interpretations relative to those with TLE and controls, and (2) if disease-related variables (e.g., age of seizure onset) predicted performances in either patient group. A total of 22 patients with FLE, 20 patients with TLE, and 23 controls were administered a test of proverb interpretation to assess their ability to grasp the abstract meaning of nonliteral language. Participants were presented with a series of proverbs and asked to provide an oral interpretation of each. Responses to each proverb were scored according to their accuracy and level of abstractness. Patients with FLE, but not TLE, were impaired relative to controls in their overall interpretation of proverbs. However a subgroup analysis revealed that only patients with left FLE showed impaired interpretation accuracy relative to the other groups, whereas patients with both left FLE and left TLE showed impaired abstraction. Patients with FLE were also impaired when they were asked to select the best interpretation of the proverb from response alternatives. In patients with FLE, only a left-sided seizure focus was associated with poorer performance. In patients with TLE, both an early age of onset and a left-sided seizure focus predicted poorer performance. Overall, FLE patients exhibit greater impairment than TLE patients in interpreting proverbs. However, the nature and disease-specific correlates of impaired performances in proverb interpretation differ between the groups. Adapted from the source document JF - The Clinical Neuropsychologist AU - McDonald, Carrie R AU - Delis, Dean C AU - Kramer, Joel H AU - Tecoma, Evelyn S AU - Iragui, Vicente J AD - Veterans Administration San Diego Healthcare System, Department of Psychiatry, University of California, San Diego, 8950 Villa La Jolla Drive, Suite C1010, La Jolla, CA 92037, USA camcdonald@ucsd.edu Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 480 EP - 496 VL - 22 IS - 3 SN - 1385-4046, 1385-4046 KW - Cerebral Dominance (11500) KW - Epilepsy (22365) KW - Brain Damage (09400) KW - Metaphors (53250) KW - Executive Function (23470) KW - Age of Onset (01157) KW - Language Thought Relationship (44410) KW - Comprehension (13950) KW - Proverbs (68865) KW - article KW - 4012: psycholinguistics; language and cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85698385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Clinical+Neuropsychologist&rft.atitle=A+Componential+Analysis+of+Proverb+Interpretation+in+Patients+with+Frontal+Lobe+Epilepsy+and+Temporal+Lobe+Epilepsy%3A+Relationships+with+Disease-Related+Factors&rft.au=McDonald%2C+Carrie+R%3BDelis%2C+Dean+C%3BKramer%2C+Joel+H%3BTecoma%2C+Evelyn+S%3BIragui%2C+Vicente+J&rft.aulast=McDonald&rft.aufirst=Carrie&rft.date=2008-05-01&rft.volume=22&rft.issue=3&rft.spage=480&rft.isbn=&rft.btitle=&rft.title=The+Clinical+Neuropsychologist&rft.issn=13854046&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2008-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CLNEEC N1 - SubjectsTermNotLitGenreText - Epilepsy (22365); Age of Onset (01157); Proverbs (68865); Metaphors (53250); Comprehension (13950); Language Thought Relationship (44410); Executive Function (23470); Cerebral Dominance (11500); Brain Damage (09400) ER - TY - JOUR T1 - Noncardiac chest pain. AN - 85417859; pmid-18364579 AB - Noncardiac chest pain (NCCP) affects approximately 1 quarter of the adult population in the United States. The pathophysiology of the disorder remains to be fully elucidated. Identified underlying mechanisms for esophageal pain include gastroesophageal reflux disease (GERD), esophageal dysmotility, and visceral hypersensitivity. Aggressive antireflux treatment has been the main therapeutic strategy for GERD-related NCCP. NCCP patients with or without spastic esophageal motor disorders are responsive to pain modulators. The value of botulinum toxin injection, endoscopic treatment for GERD, and antireflux surgery in alleviating NCCP symptoms is limited. JF - Journal of clinical gastroenterology AU - Fass, Ronnie AU - Navarro-Rodriguez, Tomás AD - The Neuroenteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, Tucson, AZ 85723-0001, USA. Ronnie.Fass@va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 636 EP - 646 VL - 42 IS - 5 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Chest Pain: diagnosis KW - Chest Pain: epidemiology KW - Chest Pain: etiology KW - Diagnosis, Differential KW - Esophageal Motility Disorders: complications KW - Esophageal Motility Disorders: diagnosis KW - Esophageal Motility Disorders: epidemiology KW - Esophageal Sphincter, Lower: physiopathology KW - Humans KW - Incidence KW - United States: epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85417859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Noncardiac+chest+pain.&rft.au=Fass%2C+Ronnie%3BNavarro-Rodriguez%2C+Tom%C3%A1s&rft.aulast=Fass&rft.aufirst=Ronnie&rft.date=2008-05-01&rft.volume=42&rft.issue=5&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Preliminary Findings from a Clinical Demonstration Project for Veterans Returning from Iraq or Afghanistan AN - 744697850; 13155814 AB - Military veterans are at high risk for nicotine dependence. This clinical demonstration project used invitational letters, referral to the National Cancer Institute's Smoking Quitline, and local Veteran Affairs prescriptions for tobacco cessation to evaluate whether this low-cost method would potentially reduce smoking in separated veterans who served in Afghanistan and Iraq. Three cohorts (500 each) of recently separated veterans from Afghanistan and Iraq were contacted by survey letters. Interested veterans received follow-up telephone calls using standardized scripts. They were referred to the National Cancer Institute's Smoking Quitline (1-877-44U-QUIT) and offered local Veteran Affairs pharmacologic treatment for smoking cessation. Forty-three percent of respondents who were smokers were interested in the clinical program; of these, 77% participated. At 2 months follow-up, 38% of participants self-reported maintained smoking abstinence. Results suggested that the intervention was feasible and assisted the small number of veterans who participated. JF - Military Medicine AU - Beckham, Jean C AU - Becker, Mary E AU - Hamlett-Berry, Kim W AU - Drury, Pamela D AU - Kang, Han K AU - Wiley, Matthew T AU - Calhoun, Patrick S AU - Moore, Scott D AU - Bright, Mary Anne AU - McFall, Miles E AD - Durham Veterans Administration Medical Center, 508 Fulton Street, 116B, Durham, NC 27705. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 448 EP - 451 PB - Association of Military Surgeons of the US, 9320 Old Georgetown Road Bethesda, MD 20814 United States of America VL - 173 IS - 5 SN - 0026-4075, 0026-4075 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744697850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+Medicine&rft.atitle=Preliminary+Findings+from+a+Clinical+Demonstration+Project+for+Veterans+Returning+from+Iraq+or+Afghanistan&rft.au=Beckham%2C+Jean+C%3BBecker%2C+Mary+E%3BHamlett-Berry%2C+Kim+W%3BDrury%2C+Pamela+D%3BKang%2C+Han+K%3BWiley%2C+Matthew+T%3BCalhoun%2C+Patrick+S%3BMoore%2C+Scott+D%3BBright%2C+Mary+Anne%3BMcFall%2C+Miles+E&rft.aulast=Beckham&rft.aufirst=Jean&rft.date=2008-05-01&rft.volume=173&rft.issue=5&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=Military+Medicine&rft.issn=00264075&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/amsus/zmm/2008/00000173/00000005/art00019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - The prescription of peritoneal dialysis. AN - 71647069; 18248525 AB - In addition to the maintenance of normal extracellular electrolyte composition, the prescription of continuous peritoneal dialysis (CPD) should address four other specific issues: (i) prevention of uremia by achievement of adequate clearance of azotemic substances, (ii) prevention of progressive expansion of the extracellular volume by adequate peritoneal ultrafiltration, (iii) prevention of loss of residual renal function, and (iv) prevention of deterioration of the peritoneal membrane structure and function. Urea clearance, in the form of Kt/V(Urea), is the index of removal of azotemic substances proposed by current guidelines. The target total (renal plus peritoneal) Kt/V(Urea) is >or=1.7 weekly. To provide the desired peritoneal Kt/V(Urea) (K(p)t/V(Urea)), the prescription of peritoneal dialysis must provide a daily drain volume (Dv) defined by the clearance equations as Dv = V x (K(p)t/V(Urea))/(D/P(Urea)), where V is body water obtained from published anthropometric formulas, K(p)t/V(Urea) = (1.7 - renal Kt/V(Urea))/7 and D/P(Urea) is the dialysate-to-plasma urea concentration ratio at the dwell time prescribed. Computer programs obtain the relevant D/P(Urea) values from formal studies of peritoneal transport. In the absence of these studies (for example, at initiation of CPD), D/P(Urea) values can be obtained from published studies with similar dwell times. Body size, indicated by V, is the major determinant of the K(p)t/V(Urea) limit provided by a given CPD schedule. Other obstacles to achievement of adequate urea clearance are created by poor patient compliance, inaccuracies of the anthropometric formulas estimating V, and mechanical complications of CPD that lead to retention of dialysate in the body. The main requirements for the prescription of adequate ultrafiltration are knowledge of the individual peritoneal transport characteristics, monitoring of urinary volume, and restriction of dietary sodium intake. Excessive dietary sodium intake is the major cause of extracellular volume expansion in CPD. Ideally, sodium intake should be kept at the level of total (peritoneal plus renal) sodium removal. Preventing the loss of residual renal function involves avoidance of nephrotoxic influences in the form of medications, radiocontrast agents, urinary obstruction and infection, and possibly other influences, such an elevated calcium-phosphorus product and anemia. Use of the lowest dialysate dextrose concentration that will allow adequate ultrafiltration is currently the most widespread practical measure of prevention of peritoneal membrane deterioration. Formulation of biocompatible dialysate is a major ongoing research effort and may greatly enhance the success of CPD in the future. JF - Seminars in dialysis AU - Tzamaloukas, Antonios H AU - Raj, Dominic S C AU - Onime, Aideloje AU - Servilla, Karen S AU - Vanderjagt, Dorothy J AU - Murata, Glen H AD - Renal Section, Department of Medicine, New Mexico VA Health Care System, 1501 San Pedro, SE, Albuquerque, NM 87108, USA. antonios.tzamaloukas@med.va.gov PY - 2008 SP - 250 EP - 257 VL - 21 IS - 3 SN - 0894-0959, 0894-0959 KW - Dialysis Solutions KW - 0 KW - Urea KW - 8W8T17847W KW - Index Medicus KW - Urea -- metabolism KW - Humans KW - Uremia -- prevention & control KW - Peritoneal Dialysis, Continuous Ambulatory KW - Kidney Failure, Chronic -- metabolism KW - Dialysis Solutions -- administration & dosage KW - Decision Making, Computer-Assisted KW - Kidney Failure, Chronic -- physiopathology KW - Dialysis Solutions -- metabolism KW - Kidney Failure, Chronic -- therapy KW - Dialysis Solutions -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71647069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+dialysis&rft.atitle=The+prescription+of+peritoneal+dialysis.&rft.au=Tzamaloukas%2C+Antonios+H%3BRaj%2C+Dominic+S+C%3BOnime%2C+Aideloje%3BServilla%2C+Karen+S%3BVanderjagt%2C+Dorothy+J%3BMurata%2C+Glen+H&rft.aulast=Tzamaloukas&rft.aufirst=Antonios&rft.date=2008-05-01&rft.volume=21&rft.issue=3&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Seminars+in+dialysis&rft.issn=08940959&rft_id=info:doi/10.1111%2Fj.1525-139X.2007.00412.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-31 N1 - Date created - 2008-06-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Semin Dial. 2009 Mar-Apr;22(2):221 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1525-139X.2007.00412.x ER - TY - JOUR T1 - Current status of cannabis treatment of multiple sclerosis with an illustrative case presentation of a patient with MS, complex vocal tics, paroxysmal dystonia, and marijuana dependence treated with dronabinol. AN - 70753286; 18496477 AB - Pain, spasticity, tremor, spasms, poor sleep quality, and bladder and bowel dysfunction, among other symptoms, contribute significantly to the disability and impaired quality of life of many patients with multiple sclerosis (MS). Motor symptoms referable to the basal ganglia, especially paroxysmal dystonia, occur rarely and contribute to the experience of distress. A substantial percentage of patients with MS report subjective benefit from what is often illicit abuse of extracts of the Cannabis sativa plant; the main cannabinoids include delta-9-tetrahydrocannabinol (delta9-THC) and cannabidiol. Clinical trials of cannabis plant extracts and synthetic delta9-THC provide support for therapeutic benefit on at least some patient self-report measures. An illustrative case is presented of a 52-year-old woman with MS, paroxysmal dystonia, complex vocal tics, and marijuana dependence. The patient was started on an empirical trial of dronabinol, an encapsulated form of synthetic delta9-THC that is usually prescribed as an adjunctive medication for patients undergoing cancer chemotherapy. The patient reported a dramatic reduction of craving and illicit use; she did not experience the "high" on the prescribed medication. She also reported an improvement in the quality of her sleep with diminished awakenings during the night, decreased vocalizations, and the tension associated with their emission, decreased anxiety and a decreased frequency of paroxysmal dystonia. JF - CNS spectrums AU - Deutsch, Stephen I AU - Rosse, Richard B AU - Connor, Julie M AU - Burket, Jessica A AU - Murphy, Mary E AU - Fox, Fiona J AD - Mental Health Service Line, Department of Veterans Affairs Medical Center, Washington, DC, USA. stephen.deutsch@med.va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 393 EP - 403 VL - 13 IS - 5 SN - 1092-8529, 1092-8529 KW - Hallucinogens KW - 0 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Female KW - Phytotherapy -- methods KW - Dronabinol -- therapeutic use KW - Multiple Sclerosis -- complications KW - Nocturnal Paroxysmal Dystonia -- etiology KW - Nocturnal Paroxysmal Dystonia -- therapy KW - Marijuana Abuse -- drug therapy KW - Cannabis KW - Multiple Sclerosis -- therapy KW - Hallucinogens -- therapeutic use KW - Tics -- therapy KW - Tics -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70753286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CNS+spectrums&rft.atitle=Current+status+of+cannabis+treatment+of+multiple+sclerosis+with+an+illustrative+case+presentation+of+a+patient+with+MS%2C+complex+vocal+tics%2C+paroxysmal+dystonia%2C+and+marijuana+dependence+treated+with+dronabinol.&rft.au=Deutsch%2C+Stephen+I%3BRosse%2C+Richard+B%3BConnor%2C+Julie+M%3BBurket%2C+Jessica+A%3BMurphy%2C+Mary+E%3BFox%2C+Fiona+J&rft.aulast=Deutsch&rft.aufirst=Stephen&rft.date=2008-05-01&rft.volume=13&rft.issue=5&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=CNS+spectrums&rft.issn=10928529&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-07 N1 - Date created - 2008-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Approach to patients with symptoms of food allergy. AN - 69168403; 18456029 AB - "Allergy" is a term often used by patients to describe symptoms that arise after eating. The term "adverse reaction to food" is preferred unless the event has an immunologic basis. True food allergy, primarily mediated by immunoglobulin (Ig)E antibodies to food proteins, is present in 3% to 4% of US adults. Symptoms range from mild mouth itching ("oral allergy syndrome") to anaphylaxis. The diagnosis is established by history and appropriately performed skin testing or in vitro assays for specific IgE antibodies to the suspected food. Because food-allergic reactions can be fatal, it is important to identify and avoid the causative food. Food-allergic reactions are treated by prompt use of intramuscular epinephrine. Patients may be referred to an allergy/immunology specialist when the diagnosis is uncertain or if avoidance measures are not successful. Investigational therapies may ultimately be preventative or curative. JF - The American journal of medicine AU - Bush, Robert K AD - Department of Medicine, Section of Allergy/Immunology, Pulmonary, Sleep and Critical Care Medicine, University of Wisconsin-Madison and the William S. Middleton Memorial VA Hospital, Madison, WI 53705, USA. Robert.Bush@va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 376 EP - 378 VL - 121 IS - 5 KW - Sympathomimetics KW - 0 KW - Immunoglobulin E KW - 37341-29-0 KW - Epinephrine KW - YKH834O4BH KW - Abridged Index Medicus KW - Index Medicus KW - Sympathomimetics -- therapeutic use KW - Immunoglobulin E -- blood KW - Skin Tests KW - Humans KW - Food Contamination KW - Epinephrine -- therapeutic use KW - Food Hypersensitivity -- blood KW - Food Hypersensitivity -- diagnosis KW - Food Hypersensitivity -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69168403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Approach+to+patients+with+symptoms+of+food+allergy.&rft.au=Bush%2C+Robert+K&rft.aulast=Bush&rft.aufirst=Robert&rft.date=2008-05-01&rft.volume=121&rft.issue=5&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=1555-7162&rft_id=info:doi/10.1016%2Fj.amjmed.2007.07.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-22 N1 - Date created - 2008-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.amjmed.2007.07.036 ER - TY - JOUR T1 - Risk for nephrogenic systemic fibrosis with gadoteridol (ProHance) in patients who are on long-term hemodialysis. AN - 69146087; 18287249 AB - Recent studies strongly link nephrogenic systemic fibrosis to gadolinium administration for magnetic resonance imaging. In a recent advisory, the Food and Drug Administration stated that all gadolinium-containing chelates are potentially associated with nephrogenic systemic fibrosis; however, most reported cases are linked to gadodiamide (Omniscan) and gadopentetate dimeglumine (Magnevist). Given the severe consequences of nephrogenic systemic fibrosis, it is critical to define the risks associated with each gadolinium-containing chelate. The purpose of this study was to examine nephrogenic systemic fibrosis risk in a hemodialysis population exposed to gadoteridol (ProHance). Appointment logs were used to generate a database of all long-term hemodialysis patients at the Dallas Veterans Affairs hospital since August 2001. These patients were then examined in the Veterans Affair's electronic medical record system for gadolinium exposure during magnetic resonance imaging from 2000 through 2007, a period during which gadoteridol was the sole contrast agent used. A total of 141 patients were identified with 198 gadoteridol exposures. No cases of nephrogenic systemic fibrosis were identified. The observed frequency of nephrogenic systemic fibrosis was compared with the expected frequency (2.4%) using one-way chi(2) and binomial analysis, yielding a P < 0.05, indicating that the result was not explained by chance alone. It is concluded that the risk for nephrogenic systemic fibrosis with gadoteridol in patients who are on long-term hemodialysis may be lower than with gadodiamide and gadopentetate dimeglumine. JF - Clinical journal of the American Society of Nephrology : CJASN AU - Reilly, Robert F AD - Division of Nephrology, Veterans Affairs North Texas Health Care System and University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA. robert.reilly2@va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 747 EP - 751 VL - 3 IS - 3 KW - Contrast Media KW - 0 KW - Heterocyclic Compounds KW - Organometallic Compounds KW - gadoversetamide KW - gadoteridol KW - 0199MV609F KW - gadodiamide KW - 84F6U3J2R6 KW - Gadolinium KW - AU0V1LM3JT KW - Gadolinium DTPA KW - K2I13DR72L KW - Index Medicus KW - Gadolinium DTPA -- adverse effects KW - Magnetic Resonance Imaging KW - Fibrosis KW - Humans KW - Aged KW - Texas KW - Risk Assessment KW - Magnetic Resonance Angiography KW - Middle Aged KW - Time Factors KW - Female KW - Male KW - Hospitals, Veterans KW - Contrast Media -- adverse effects KW - Kidney Diseases -- pathology KW - Kidney Failure, Chronic -- pathology KW - Kidney Failure, Chronic -- therapy KW - Skin Diseases -- pathology KW - Renal Dialysis KW - Organometallic Compounds -- adverse effects KW - Heterocyclic Compounds -- adverse effects KW - Skin Diseases -- chemically induced KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69146087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+journal+of+the+American+Society+of+Nephrology+%3A+CJASN&rft.atitle=Risk+for+nephrogenic+systemic+fibrosis+with+gadoteridol+%28ProHance%29+in+patients+who+are+on+long-term+hemodialysis.&rft.au=Reilly%2C+Robert+F&rft.aulast=Reilly&rft.aufirst=Robert&rft.date=2008-05-01&rft.volume=3&rft.issue=3&rft.spage=747&rft.isbn=&rft.btitle=&rft.title=Clinical+journal+of+the+American+Society+of+Nephrology+%3A+CJASN&rft.issn=1555-905X&rft_id=info:doi/10.2215%2FCJN.05721207 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Radiology. 2008 Jan;246(1):11-4 [17855656] Semin Dial. 2008 Mar-Apr;21(2):129-34 [18225999] Invest Radiol. 2007 Feb;42(2):139-45 [17220732] J Am Soc Nephrol. 2003 Jul;14(7 Suppl 2):S192-4 [12819327] Nephrol Dial Transplant. 2006 Apr;21(4):1104-8 [16431890] J Am Soc Nephrol. 2006 Sep;17(9):2359-62 [16885403] Arthritis Rheum. 2007 Oct;56(10):3433-41 [17907148] AJR Am J Roentgenol. 2007 Feb;188(2):586-92 [17242272] MMWR Morb Mortal Wkly Rep. 2007 Feb 23;56(7):137-41 [17318112] Radiology. 2007 Apr;243(1):148-57 [17267695] AJR Am J Roentgenol. 2007 Jun;188(6):1447-74 [17515363] Clin J Am Soc Nephrol. 2007 Mar;2(2):264-7 [17699423] Comment In: Clin J Am Soc Nephrol. 2008 May;3(3):649-51 [18385396] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2215/CJN.05721207 ER - TY - JOUR T1 - Serial evaluations of myocardial infarct size after alcohol septal ablation in hypertrophic cardiomyopathy and effects of the changes on clinical status and left ventricular outflow pressure gradients. AN - 69136693; 18435966 AB - Alcohol septal ablation (ASA) as a treatment for obstructive hypertrophic cardiomyopathy produces septal infarction. There is a concern that such infarcts could be detrimental. Changes in the size of these infarcts by serial perfusion testing have not been studied. We performed resting serial-gated single-photon emission computed tomographic myocardial perfusion imaging in 30 patients (age 51+/-17 years, 57% were women) who had ASA between September 2003 and March 2007 before, 2+/-0.8 days (early), and 8.4+/-6.9 months (late) after ASA. Patients were also followed clinically and with serial 2-dimensional echocardiography. New York Heart Association class decreased from 3.50+/-0.51 before to 1.14+/-0.36 (p<0.0001) 3 months after ASA. The left ventricular (LV) outflow gradient (by Doppler echocardiography) decreased from 63+/-32 mm Hg before to 28+/-23 mm Hg after ASA (p<0.005). None of the patients had perfusion defects at rest before ASA. After ASA, perfusion defect size, involving the basal septum, decreased from 9.4+/-5.8% early to 5.2+/-4.2% of LV myocardium late after ASA (p<0.001). There were no changes in LV size and ejection fraction after ASA. In conclusion, ASA produces small basal ventricular septal infarcts (resting perfusion abnormality) involving<10% of the LV myocardium (including ventricular septum). There is a significant reduction in the perfusion abnormality late after ASA without an increase in LV outflow obstruction or recurrence of symptoms. JF - The American journal of cardiology AU - Aqel, Raed A AU - Hage, Fadi G AU - Zohgbi, Gilbert J AU - Tabereaux, Paul B AU - Lawson, David AU - Heo, Jaekyeong AU - Perry, Gilbert AU - Epstein, Andrew E AU - Dell' Italia, Louis J AU - Iskandrian, Ami E AD - Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham and the Birmingham Veterans Affairs Medical Center, Birmingham, Alabama, USA. raed.aqel@med.va.gov Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 1328 EP - 1333 VL - 101 IS - 9 SN - 0002-9149, 0002-9149 KW - Radiopharmaceuticals KW - 0 KW - Ethanol KW - 3K9958V90M KW - Technetium Tc 99m Sestamibi KW - 971Z4W1S09 KW - Abridged Index Medicus KW - Index Medicus KW - Tomography, Emission-Computed, Single-Photon KW - Humans KW - Chi-Square Distribution KW - Linear Models KW - Treatment Outcome KW - Echocardiography, Doppler KW - Middle Aged KW - Ventricular Pressure KW - Male KW - Female KW - Myocardial Infarction -- pathology KW - Cardiomyopathy, Hypertrophic -- diagnostic imaging KW - Ventricular Outflow Obstruction -- physiopathology KW - Myocardial Infarction -- chemically induced KW - Myocardial Infarction -- diagnostic imaging KW - Ventricular Outflow Obstruction -- therapy KW - Cardiomyopathy, Hypertrophic -- therapy KW - Ventricular Outflow Obstruction -- diagnostic imaging KW - Cardiomyopathy, Hypertrophic -- physiopathology KW - Ethanol -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69136693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Serial+evaluations+of+myocardial+infarct+size+after+alcohol+septal+ablation+in+hypertrophic+cardiomyopathy+and+effects+of+the+changes+on+clinical+status+and+left+ventricular+outflow+pressure+gradients.&rft.au=Aqel%2C+Raed+A%3BHage%2C+Fadi+G%3BZohgbi%2C+Gilbert+J%3BTabereaux%2C+Paul+B%3BLawson%2C+David%3BHeo%2C+Jaekyeong%3BPerry%2C+Gilbert%3BEpstein%2C+Andrew+E%3BDell%27+Italia%2C+Louis+J%3BIskandrian%2C+Ami+E&rft.aulast=Aqel&rft.aufirst=Raed&rft.date=2008-05-01&rft.volume=101&rft.issue=9&rft.spage=1328&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/10.1016%2Fj.amjcard.2007.12.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-17 N1 - Date created - 2008-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.amjcard.2007.12.042 ER - TY - JOUR T1 - Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. AN - 69126650; 18431127 AB - Lipid emulsion infusion reverses cardiovascular compromise due to local anesthetic overdose in laboratory and clinical settings. The authors compared resuscitation with lipid, epinephrine, and saline control in a rat model of bupivacaine-induced cardiac toxicity to determine whether lipid provides a benefit over epinephrine. Bupivacaine, 20 mg/kg, was infused in rats anesthetized with isoflurane, producing asystole in all subjects. Ventilation with 100% oxygen and chest compressions were begun immediately, along with intravenous treatment with 30% lipid emulsion or saline (5-ml/kg bolus plus continuous infusion at 0.5 ml . kg . min) or epinephrine (30 microg/kg). Chest compressions were continued and boluses were repeated at 2.5 and 5 min until the native rate-pressure product was greater than 20% baseline. Electrocardiogram and arterial pressure were monitored continuously and at 10 min, arterial blood gas, central venous oxygen saturation, and blood lactate were measured. Effect size (Cohen d) was determined for comparisons at 10 min. Lipid infusion resulted in higher rate-pressure product (P < 0.001, d = 3.84), pH (P < 0.01, d = 3.78), arterial oxygen tension (P < 0.05, d = 2.8), and central venous oxygen saturation (P < 0.001, d = 4.9) at 10 min than did epinephrine. Epinephrine treatment caused higher lactate (P < 0.01, d = 1.48), persistent ventricular ectopy in all subjects, pulmonary edema in four of five rats, hypoxemia, and a mixed metabolic and respiratory acidosis by 10 min. Hemodynamic and metabolic metrics during resuscitation with lipid surpassed those with epinephrine, which were no better than those seen in the saline control group. Further studies are required to optimize the clinical management of systemic local anesthetic toxicity. JF - Anesthesiology AU - Weinberg, Guy L AU - Di Gregorio, Guido AU - Ripper, Richard AU - Kelly, Kemba AU - Massad, Malek AU - Edelman, Lucas AU - Schwartz, David AU - Shah, Nirali AU - Zheng, Sophie AU - Feinstein, Douglas L AD - Department of Anesthesiology, University of Illinois College of Medicine at Chicago and Jesse Brown Veterans Administration Medical Center, Chicago, Illinois 60612, USA. guyw@uic.edu Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 907 EP - 913 VL - 108 IS - 5 KW - Anesthetics, Local KW - 0 KW - Lipids KW - Bupivacaine KW - Y8335394RO KW - Epinephrine KW - YKH834O4BH KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Infusions, Intravenous KW - Heart -- drug effects KW - Disease Models, Animal KW - Anesthetics, Local -- toxicity KW - Anesthetics, Local -- therapeutic use KW - Male KW - Bupivacaine -- therapeutic use KW - Epinephrine -- pharmacology KW - Lipids -- therapeutic use KW - Bupivacaine -- toxicity KW - Drug Overdose -- prevention & control KW - Resuscitation -- methods KW - Bupivacaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69126650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=Resuscitation+with+lipid+versus+epinephrine+in+a+rat+model+of+bupivacaine+overdose.&rft.au=Weinberg%2C+Guy+L%3BDi+Gregorio%2C+Guido%3BRipper%2C+Richard%3BKelly%2C+Kemba%3BMassad%2C+Malek%3BEdelman%2C+Lucas%3BSchwartz%2C+David%3BShah%2C+Nirali%3BZheng%2C+Sophie%3BFeinstein%2C+Douglas+L&rft.aulast=Weinberg&rft.aufirst=Guy&rft.date=2008-05-01&rft.volume=108&rft.issue=5&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Anesthesiology&rft.issn=1528-1175&rft_id=info:doi/10.1097%2FALN.0b013e31816d91d2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-28 N1 - Date created - 2008-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/ALN.0b013e31816d91d2 ER - TY - JOUR T1 - Intimate Partner Violence and Miscarriage: Examination of the Role of Physical and Psychological Abuse and Posttraumatic Stress Disorder AN - 61692950; 200822007 AB - Despite research documenting high rates of violence during pregnancy, few studies have examined the impact of physical abuse, psychological abuse, and posttraumatic stress disorder (PTSD) on miscarriage. Secondary analysis of data collected by the Chicago Women's Health Risk Study permitted an exploration of the relationships among physical abuse, psychological abuse, PTSD, and miscarriage among 118 primarily ethnic minority women. The interaction between maximum severity of abuse and age provided the best multivariate predictor of miscarriage rate, accounting for 26.9% of the variance between live birth and miscarriage outcome. Mean scores of psychological abuse, physical violence, forced sex, and PTSD were significantly higher in the miscarriage group than in the live birth group. Women who experience physical violence and psychological abuse during pregnancy may be at greater risk for miscarriage. Prospective studies can confirm findings and determine underlying mechanisms. Routine screening for traumatic stress and PTSD may reduce rates of miscarriage. [Reprinted by permission of Sage Publications Inc., copyright 2008.] JF - Journal of Interpersonal Violence AU - Morland, Leslie A AU - Leskin, Gregory A AU - Block, Carolyn Rebecca AU - Campbell, Jacquelyn C AU - Friedman, Matthew J AD - National Center for PTSD leslie.morland@med.va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 652 EP - 669 PB - Sage Publications, Thousand Oaks CA VL - 23 IS - 5 SN - 0886-2605, 0886-2605 KW - posttraumatic stress disorder PTSD psychological abuse physical abuse miscarriage KW - Chicago, Illinois KW - Emotional Abuse KW - Partner Abuse KW - Posttraumatic Stress Disorder KW - Pregnancy KW - Miscarriage KW - article KW - 2190: social problems and social welfare; victimology (rape, family violence, & child abuse) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61692950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interpersonal+Violence&rft.atitle=Intimate+Partner+Violence+and+Miscarriage%3A+Examination+of+the+Role+of+Physical+and+Psychological+Abuse+and+Posttraumatic+Stress+Disorder&rft.au=Morland%2C+Leslie+A%3BLeskin%2C+Gregory+A%3BBlock%2C+Carolyn+Rebecca%3BCampbell%2C+Jacquelyn+C%3BFriedman%2C+Matthew+J&rft.aulast=Morland&rft.aufirst=Leslie&rft.date=2008-05-01&rft.volume=23&rft.issue=5&rft.spage=652&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interpersonal+Violence&rft.issn=08862605&rft_id=info:doi/10.1177%2F0886260507313533 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 41 N1 - Last updated - 2016-09-28 N1 - CODEN - JIVIEI N1 - SubjectsTermNotLitGenreText - Miscarriage; Emotional Abuse; Posttraumatic Stress Disorder; Pregnancy; Partner Abuse; Chicago, Illinois DO - http://dx.doi.org/10.1177/0886260507313533 ER - TY - JOUR T1 - The cost-effectiveness of a smoking cessation program for out-patients in treatment for depression AN - 57280756; 200908210 AB - Aims Smoking cessation programs are highly cost-effective. The cost-effectiveness of programs for psychiatric patients may be affected by differences in cost, efficacy, survival and quality of life. We evaluated cost-effectiveness of a program for smokers being treated for depression. Design A randomized trial compared brief contact to a stepped smoking cessation program in 322 cigarette smoking mental health out-patients. We determined the intervention's direct cost. Because smoking cessation may affect short-term use of mental health care, we used administrative databases and self-report to find mental health-care cost. Findings The 163 individuals randomized to stepped care received an average of$346 of smoking cessation services, including$221 for computer-mediated assessments of readiness to quit, and$124 for counseling, nicotine replacement therapy and bupropion. The cessation program was used by 53 participants. Total cost of smoking cessation and mental health services was. Adapted from the source document. JF - Addiction AU - Barnett, Paul G AU - Wong, Wynnie AU - Hall, Sharon AD - Department of Psychiatry, University of California, San Francisco, CA, USA paul.barnett@va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 834 EP - 840 PB - Blackwell Publishing, Oxford UK VL - 103 IS - 5 SN - 0965-2140, 0965-2140 KW - Smoking KW - Depression KW - Efficacy KW - Bupropion KW - Cessation KW - Cost effectiveness KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57280756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=The+cost-effectiveness+of+a+smoking+cessation+program+for+out-patients+in+treatment+for+depression&rft.au=Barnett%2C+Paul+G%3BWong%2C+Wynnie%3BHall%2C+Sharon&rft.aulast=Barnett&rft.aufirst=Paul&rft.date=2008-05-01&rft.volume=103&rft.issue=5&rft.spage=834&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2008.02167.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Cessation; Smoking; Cost effectiveness; Depression; Bupropion; Efficacy DO - http://dx.doi.org/10.1111/j.1360-0443.2008.02167.x ER - TY - JOUR T1 - Nurse and patient communication profiles in a home-based telehealth intervention for heart failure management AN - 57273271; 200913297 AB - Objective This study compared differences in nurse and patient communication profiles between two telehealth modes: telephone and videophone, and evaluated longitudinal changes in communication, nurse perceptions, and patient satisfaction. Methods Subjects were enrolled in a randomized controlled clinical trial evaluating a 90-day home-based intervention for heart failure. Telephone (n = 14) and videophone (n = 14) interactions were audio taped and analyzed using the Roter Interaction Analysis System. Results Nurses were more likely to use open-ended questions, back-channel responses, friendly jokes, and checks for understanding on the telephone compared to videophone. Compliments given and partnership were more common on the videophone. Patients were more likely to give lifestyle information and approval comments on the telephone, and used more closed-ended questions on the videophone. Nurses perceptions of the interactions were not different between the telephone and videophone, nor did their perceptions change significantly over the course of the intervention. There were no significant differences in patient satisfaction between the telephone and videophone. Conclusions The results of this study did not support use of a videophone over the telephone. Practice implications It is critical to match technologies to patient needs and use the least complex technology possible. When considering use a videophone, health care providers should critically examine the trade-offs between additional complexities with the added value of the visual interaction. [Copyright Elsevier B.V.] JF - Patient Education and Counseling AU - Wakefield, Bonnie J AU - Bylund, Carma L AU - Holman, John E AU - Ray, Annette AU - Scherubel, Melody AU - Kienzle, Michael G AU - Rosenthal, Gary E AD - Research Service, Harry S. Truman Memorial Veterans Hospital, 800 Hospital Drive, Columbia, MO 65201, United States bonnie.wakefield@va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 285 EP - 292 PB - Elsevier Ltd, The Netherlands VL - 71 IS - 2 SN - 0738-3991, 0738-3991 KW - Telehealth Nursing Heart failure Communication Remote monitoring KW - Perceptions KW - Home based KW - Patient satisfaction KW - Nurse-Patient communication KW - Telephone calls KW - Telemedicine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57273271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Patient+Education+and+Counseling&rft.atitle=Nurse+and+patient+communication+profiles+in+a+home-based+telehealth+intervention+for+heart+failure+management&rft.au=Wakefield%2C+Bonnie+J%3BBylund%2C+Carma+L%3BHolman%2C+John+E%3BRay%2C+Annette%3BScherubel%2C+Melody%3BKienzle%2C+Michael+G%3BRosenthal%2C+Gary+E&rft.aulast=Wakefield&rft.aufirst=Bonnie&rft.date=2008-05-01&rft.volume=71&rft.issue=2&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Patient+Education+and+Counseling&rft.issn=07383991&rft_id=info:doi/10.1016%2Fj.pec.2008.01.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nurse-Patient communication; Telephone calls; Perceptions; Patient satisfaction; Telemedicine; Home based DO - http://dx.doi.org/10.1016/j.pec.2008.01.006 ER - TY - JOUR T1 - Impacts of age of onset of substance use disorders on risk of adult incarceration among disadvantaged urban youth: A propensity score matching approach AN - 57259805; 200820502 AB - Background: Age of onset of substance use disorders in adolescence and early adulthood could be associated with higher rates of adult criminal incarceration in the U.S., but evidence of these associations is scarce. Methods: Propensity score matching was used to estimate the association between adolescent-onset substance use disorders and the rate of incarceration, as well as incarceration costs and self-reported criminal arrests and convictions, of young men predominantly from African American, lower income, urban households. Age of onset was differentiated by whether onset of the first disorder occurred by age 16. Results: Onset of a substance use disorder by age 16, but not later onset, was associated with a fourfold greater risk of adult incarceration for substance related offenses as compared to no disorder (0.35 vs. 0.09, P = 0.044). Onset by age 16 and later onset were both positively associated with incarceration costs and risk of arrest and conviction, though associations with crime outcomes were more consistent with respect to onset by age 16. Results were robust to propensity score adjustment for observable predictors of substance use in adolescence and involvement in crime as an adult. Conclusion: Among young men in this high risk minority sample, having a substance use disorder by age 16 was associated with higher risk of incarceration for substance related offenses in early adulthood and with more extensive criminal justice system involvement as compared to having no disorder or having a disorder beginning at a later age. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Slade, Eric P AU - Stuart, Elizabeth A AU - Salkever, David S AU - Karakus, Mustafa AU - Green, Kerry M AU - Ialongo, Nicholas AD - University of Maryland School of Medicine, and U.S. Department of Veterans Affairs 737 W. Lombard Street, Room 526, Baltimore, MD 21201, United States eslade@psych.umaryland.edu Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 1 EP - 13 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 95 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Incarceration KW - Substance use disorder KW - Adolescence KW - Longitudinal KW - African American KW - Imprisonment KW - Black American people KW - Early onset KW - Substance abuse disorders KW - Criminal justice system KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57259805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Impacts+of+age+of+onset+of+substance+use+disorders+on+risk+of+adult+incarceration+among+disadvantaged+urban+youth%3A+A+propensity+score+matching+approach&rft.au=Slade%2C+Eric+P%3BStuart%2C+Elizabeth+A%3BSalkever%2C+David+S%3BKarakus%2C+Mustafa%3BGreen%2C+Kerry+M%3BIalongo%2C+Nicholas&rft.aulast=Slade&rft.aufirst=Eric&rft.date=2008-05-01&rft.volume=95&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.11.019 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Imprisonment; Adolescence; Early onset; Substance abuse disorders; Criminal justice system; Black American people DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.11.019 ER - TY - JOUR T1 - Considering Adaptation in Preference Elicitations AN - 57259356; 200823358 AB - Objective: Patients with chronic health conditions usually place higher utility on their condition than the public does. One explanation for this discrepancy is that healthy people focus on the negative aspects of the condition without considering their own ability to emotionally adapt to the condition over time. The aim of this randomized experimental study was to test whether people would give higher utility ratings for chronic health conditions when they were encouraged to consider their own ability to adapt to difficult situations before giving their ratings. Main Outcome Measure: Utility ratings for four chronic health conditions. Results: The authors presented scenarios describing 4 chronic health conditions to 1, 117 respondents drawn from a demographically balanced U.S. Internet panel. The adaptation exercise did not influence respondents' valuations. However, utility values increasingly improved with decreasing ratings of how upsetting it would be to live with the condition over time. Conclusion: The authors speculate that asking people to think about adaptation changes their evaluations of what it would feel like to live with chronic illness, but doing so does not change how much they are willing to trade off to avoid that chronic illness. [Copyright 2008 The American Psychological Association.] JF - Health Psychology AU - Damschroder, Laura J AU - Zikmund-Fisher, Brian J AU - Ubel, Peter A AD - Center for Practice Management, Outcomes Research, 2215 Fuller Road, Ann Arbor, MI 48105 laura.damschroder@va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 394 EP - 399 PB - American Psychological Association, Washington DC VL - 27 IS - 3 SN - 0278-6133, 0278-6133 KW - utility, adaptation, computerized elicitation KW - Adaptation KW - Chronic diseases KW - Utility KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57259356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Psychology&rft.atitle=Considering+Adaptation+in+Preference+Elicitations&rft.au=Damschroder%2C+Laura+J%3BZikmund-Fisher%2C+Brian+J%3BUbel%2C+Peter+A&rft.aulast=Damschroder&rft.aufirst=Laura&rft.date=2008-05-01&rft.volume=27&rft.issue=3&rft.spage=394&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2F0278-6133.27.3.394 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-12-09 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Utility; Adaptation; Chronic diseases DO - http://dx.doi.org/10.1037/0278-6133.27.3.394 ER - TY - JOUR T1 - Chronic Fatigue Syndrome in Male Gulf War Veterans and Civilians: A Further Test of the Single Syndrome Hypothesis AN - 57256360; 200819042 AB - Different modes of fatigue onset in male Gulf War veterans versus male civilians raise the possibility that chronic fatigue syndrome (CFS) may not be a single disease entity. We addressed this issue by comparing 45 male veterans with CFS to 84 male civilians who satisfied identical case criteria. All were evaluated for fibromyalgia (FM), multiple chemical sensitivity and psychiatric comorbidity. CFS was more likely to present in a sudden flu-like manner in civilians than veterans (p < .01) and comorbid FM was more prevalent in civilians (p < .01). These findings question the assumption that all patients with CFS suffer from the same underlying disorder. [Copyright 2008 Sage Publications Ltd.] JF - Journal of Health Psychology AU - Ciccone, Donald S AU - Weissman, Lois AU - Natelson, Benjamin H AD - UMDNJ-New Jersey Medical School, USA donald.ciccone@va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 529 EP - 536 PB - Sage Publications, London UK VL - 13 IS - 4 SN - 1359-1053, 1359-1053 KW - comorbidity KW - diagnosis KW - fatigue KW - medically unexplained illness KW - veteran KW - Multiple Chemical Sensitivity KW - Idiopathic KW - Veterans KW - Men KW - Chronic fatigue syndrome KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57256360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Psychology&rft.atitle=Chronic+Fatigue+Syndrome+in+Male+Gulf+War+Veterans+and+Civilians%3A+A+Further+Test+of+the+Single+Syndrome+Hypothesis&rft.au=Ciccone%2C+Donald+S%3BWeissman%2C+Lois%3BNatelson%2C+Benjamin+H&rft.aulast=Ciccone&rft.aufirst=Donald&rft.date=2008-05-01&rft.volume=13&rft.issue=4&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Psychology&rft.issn=13591053&rft_id=info:doi/10.1177%2F1359105308088525 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JHPSFC N1 - SubjectsTermNotLitGenreText - Men; Veterans; Comorbidity; Chronic fatigue syndrome; Idiopathic; Multiple Chemical Sensitivity DO - http://dx.doi.org/10.1177/1359105308088525 ER - TY - JOUR T1 - Influence of race and ethnicity on alternative medicine as a self-treatment preference for common medical conditions in a population of multi-ethnic urban elderly AN - 57236450; 200813478 AB - Context The research results on the relationship between social factors and attitudes toward complementary and alternative medicines (CAMs) and conventional practitioners are equivocal. Some researchers theorize a relationship between social factors and attitudes toward providers, with CAM being more attractive to socially and economically marginalized groups. Objectives To evaluate the relationships between selected sociodemographic factors and attitudes toward CAMs in the general US population. Design A subset of data from a 1997-1998 nationally representative survey was examined using descriptive and univariate analyses. Results Five outcomes exploring preference for CAM or conventional medical practitioners are considered. Age was positively related to favoring one's conventional medical doctor. Subjects who reported using CAM for wellness/prevention reported significantly less confidence in their conventional doctors than individuals who did not report using CAM for wellness/prevention. Those with low income were also significantly less confident in their medical doctors and less satisfied with their conventional medical practitioners than those with higher incomes. Conclusions While more prospective work is needed, this analysis suggests that social factors may be related to practitioner preference. Finding out why these relationships exist is important for the effectiveness of health care. [Copyright 2007 Elsevier Ltd.] JF - Complementary Therapies in Clinical Practice AU - Cherniack, E Paul AU - Ceron-Fuentes, Jose AU - Florez, Hermes AU - Sandals, Lauran AU - Rodriguez, Osvaldo AU - Palacios, Juan Carlos AD - Division of Geriatrics and Gerontology, University of Miami Miller School of Medicine, FL, USA evan.cherniack@va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 116 EP - 123 PB - Elsevier Ltd, The Netherlands VL - 14 IS - 2 SN - 1744-3881, 1744-3881 KW - Alternative medicine KW - Elderly KW - Ethnicity KW - Elderly people KW - Socioeconomic factors KW - Race KW - Treatment preferences KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57236450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Complementary+Therapies+in+Clinical+Practice&rft.atitle=Influence+of+race+and+ethnicity+on+alternative+medicine+as+a+self-treatment+preference+for+common+medical+conditions+in+a+population+of+multi-ethnic+urban+elderly&rft.au=Cherniack%2C+E+Paul%3BCeron-Fuentes%2C+Jose%3BFlorez%2C+Hermes%3BSandals%2C+Lauran%3BRodriguez%2C+Osvaldo%3BPalacios%2C+Juan+Carlos&rft.aulast=Cherniack&rft.aufirst=E&rft.date=2008-05-01&rft.volume=14&rft.issue=2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Complementary+Therapies+in+Clinical+Practice&rft.issn=17443881&rft_id=info:doi/10.1016%2Fj.ctcp.2007.11.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-27 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Socioeconomic factors; Race; Alternative medicine; Elderly people; Treatment preferences; Ethnicity DO - http://dx.doi.org/10.1016/j.ctcp.2007.11.002 ER - TY - JOUR T1 - Wall Teichoic Acid Deficiency in Staphylococcus aureus Confers Selective Resistance to Mammalian Group IIA Phospholipase A sub(2) and Human beta -Defensin 3 AN - 20964805; 8198739 AB - Wall teichoic acids (WTAs) and membrane lipoteichoic acids (LTAs) are the major polyanionic polymers in the envelope of Staphylococcus aureus. WTAs in S. aureus play an important role in bacteriophage attachment and bacterial adherence to certain host cells, suggesting that WTAs are exposed on the cell surface and could also provide necessary binding sites for cationic antimicrobial peptides and proteins (CAMPs). Highly cationic mammalian group IIA phospholipase A sub(2) (gIIA PLA sub(2)) kills S. aureus at nanomolar concentrations by an action(s) that depends on initial electrostatic interactions, cell wall penetration, membrane phospholipid (PL) degradation, and activation of autolysins. A tagO mutant of S. aureus that lacks WTA is up to 100-fold more resistant to PL degradation and killing by gIIA PLA sub(2) and CAMP human beta -defensin 3 (HBD-3) but has the sensitivity of the wild type (wt) to other CAMPs, such as Magainin II amide, hNP1-3, LL-37, and lactoferrin. In contrast, there is little or no difference in either gIIA PLA sub(2) activity toward cell wall-depleted protoplasts of the wt and tagO strains of S. aureus or in binding of gIIA PLA sub(2) to wt and tagO strains. Scanning and transmission electron microscopy reveal increased surface protrusions in the S. aureus tagO mutant that might account for reduced activity of bound gIIA PLA sub(2) and HBD-3 toward the tagO mutant. In summary, the absence of WTA in S. aureus causes a selective increase in bacterial resistance to gIIA PLA sub(2) and HBD-3, the former apparently by reducing access and/or activity of bound antibacterial enzyme to the bacterial membrane. JF - Infection and Immunity AU - Koprivnjak, Tomaz AU - Weidenmaier, Christopher AU - Peschel, Andreas AU - Weiss, Jerrold P AD - Inflammation Program. Departments of Microbiology. Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa. Veterans' Administration Medical Center, Iowa City, Iowa 52242. Channing Laboratory, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02134. Cellular and Molecular Microbiology, Department of Medical Microbiology and Hygiene, University Hospitals Tuebingen, 72076 Tuebingen, Germany Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2169 EP - 2176 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 5 SN - 0019-9567, 0019-9567 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Phages KW - Cell surface KW - Phospholipase A2 KW - Transmission electron microscopy KW - Cyclic AMP KW - Enzymes KW - Electrostatic properties KW - Lipoteichoic acid KW - Autolysins KW - Defensins KW - Envelopes KW - cationic antimicrobial peptides KW - Teichoic acids KW - lactoferrin KW - magainins KW - Protoplasts KW - Staphylococcus aureus KW - amides KW - Phospholipids KW - Cell walls KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20964805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Wall+Teichoic+Acid+Deficiency+in+Staphylococcus+aureus+Confers+Selective+Resistance+to+Mammalian+Group+IIA+Phospholipase+A+sub%282%29+and+Human+beta+-Defensin+3&rft.au=Koprivnjak%2C+Tomaz%3BWeidenmaier%2C+Christopher%3BPeschel%2C+Andreas%3BWeiss%2C+Jerrold+P&rft.aulast=Koprivnjak&rft.aufirst=Tomaz&rft.date=2008-05-01&rft.volume=76&rft.issue=5&rft.spage=2169&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phages; Cell surface; Phospholipase A2; Transmission electron microscopy; Cyclic AMP; Enzymes; Electrostatic properties; Lipoteichoic acid; Autolysins; Defensins; cationic antimicrobial peptides; Envelopes; Teichoic acids; lactoferrin; Protoplasts; magainins; amides; Cell walls; Phospholipids; Staphylococcus aureus ER - TY - JOUR T1 - Tinea pedis in athletes AN - 20960298; 8224220 JF - International Journal of Dermatology AU - Field, Leslie A AU - Adams, Brian B AD - From the Wayne State University School of Medicine, Detroit, Michigan, and Department of Dermatology, University of Cincinnati School of Medicine and Veterans Administration Medical Center, Cincinnati, Ohio, adamsbb@email.uc.edu Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 485 EP - 492 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 47 IS - 5 KW - Physical Education Index KW - Athletes KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20960298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Dermatology&rft.atitle=Tinea+pedis+in+athletes&rft.au=Field%2C+Leslie+A%3BAdams%2C+Brian+B&rft.aulast=Field&rft.aufirst=Leslie&rft.date=2008-05-01&rft.volume=47&rft.issue=5&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Dermatology&rft.issn=1365-4632&rft_id=info:doi/10.1111%2Fj.1365-4632.2008.03443.x LA - English DB - Physical Education Index N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Athletes DO - http://dx.doi.org/10.1111/j.1365-4632.2008.03443.x ER - TY - JOUR T1 - Genetic transformation of a Corynebacterial symbiont from the Chagas disease vector Triatoma infestans AN - 20936367; 8245859 AB - Insect-borne diseases have experienced a troubling resurgence in recent years. Emergence of resistance to pesticides greatly hampers control efforts. Paratransgenesis, or the genetic transformation of bacterial symbionts of disease vectors, is an alternative to traditional approaches. Previously, we developed paratransgenic lines of Rhodnius prolixus, a vector of Chagas disease in Central America. Here, we report identification of a Corynebacterial species as a symbiont of Triatoma infestans, a leading vector of Chagas disease in South America. We have modified this bacterium to produce an immunologically active single chain antibody fragment, termed rDB3. This study establishes the basis for generating paratransgenic T. infestans as a strategy for control of Chagas disease. JF - Experimental Parasitology AU - Durvasula, R V AU - Sundaram, R K AU - Kirsch, P AU - Hurwitz, I AU - Crawford, C V AU - Dotson, E AU - Beard, C B AD - University of New Mexico, 915 Camino Del Salud NE, CRF 305, Albuquerque, NM 87131, USA, ravi.durvasula@va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 94 EP - 98 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 119 IS - 1 SN - 0014-4894, 0014-4894 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Entomology Abstracts KW - Transformation KW - Antibodies KW - Symbionts KW - Pesticides KW - Triatoma infestans KW - Vectors KW - Rhodnius prolixus KW - Chagas' disease KW - G 07790:Other Microorganisms KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - J 02350:Immunology KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20936367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Parasitology&rft.atitle=Genetic+transformation+of+a+Corynebacterial+symbiont+from+the+Chagas+disease+vector+Triatoma+infestans&rft.au=Durvasula%2C+R+V%3BSundaram%2C+R+K%3BKirsch%2C+P%3BHurwitz%2C+I%3BCrawford%2C+C+V%3BDotson%2C+E%3BBeard%2C+C+B&rft.aulast=Durvasula&rft.aufirst=R&rft.date=2008-05-01&rft.volume=119&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Experimental+Parasitology&rft.issn=00144894&rft_id=info:doi/10.1016%2Fj.exppara.2007.12.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Transformation; Antibodies; Symbionts; Pesticides; Vectors; Chagas' disease; Triatoma infestans; Rhodnius prolixus DO - http://dx.doi.org/10.1016/j.exppara.2007.12.020 ER - TY - JOUR T1 - The Peptidoglycan-Associated Lipoprotein OprL Helps Protect a Pseudomonas aeruginosa Mutant Devoid of the Transactivator OxyR from Hydrogen Peroxide-Mediated Killing during Planktonic and Biofilm Culture AN - 20883954; 8199357 AB - OxyR controls H sub(2)O sub(2)-dependent gene expression in Pseudomonas aeruginosa. Without OxyR, diluted (<10 super(7)/ml) organisms are easily killed by micromolar H sub(2)O sub(2). The goal of this study was to define proteins that contribute to oxyR mutant survival in the presence of H sub(2)O sub(2). We identified proteins in an oxyR mutant that were oxidized by using 2,4-dinitrophenylhydrazine for protein carbonyl detection, followed by identification using a two-dimensional gel/matrix-assisted laser desorption ionization-time of flight approach. Among these was the peptidoglycan-associated lipoprotein, OprL. A double oxyR oprL mutant was constructed and was found to be more sensitive to H sub(2)O sub(2) than the oxyR mutant. Provision of the OxyR-regulated alkyl hydroperoxide reductase, AhpCF, but not AhpB or the catalase, KatB, helped protect this strain against H sub(2)O sub(2). Given the sensitivity of oxyR oprL bacteria to planktonic H sub(2)O sub(2), we next tested the hypothesis that the biofilm mode of growth might protect such organisms from H sub(2)O sub(2)-mediated killing. Surprisingly, biofilm-grown oxyR oprL mutants, which (in contrast to planktonic cells) possessed no differences in catalase activity compared to the oxyR mutant, were sensitive to killing by as little as 0.5 mM H sub(2)O sub(2). Transmission electron microscopy studies revealed that the integrity of both cytoplasmic and outer membranes of oxyR and oxyR oprL mutants were compromised. These studies suggest that sensitivity to the important physiological oxidant H sub(2)O sub(2) in the exquisitely sensitive oxyR mutant bacteria is based not only upon the presence and location of OxyR-controlled antioxidant enzymes such as AhpCF but also on structural reinforcement by the peptidoglycan-associated lipoprotein OprL, especially during growth in biofilms. JF - Journal of Bacteriology AU - Panmanee, Warunya AU - Gomez, Francisco AU - Witte, David AU - Pancholi, Vijay AU - Britigan, Bradley E AU - Hassett, Daniel J AD - Departments of Molecular Genetics, Biochemistry, and Microbiology. Internal Medicine. Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0524. Veterans Administration Medical Center, Cincinnati, Ohio 45220. Laboratory of Bacterial Pathogenesis, Department of Pathology, Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210-1214 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 3658 EP - 3669 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 190 IS - 10 SN - 0021-9193, 0021-9193 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Antioxidants KW - Transmission electron microscopy KW - Outer membranes KW - Enzymes KW - Survival KW - Cell culture KW - Hydrogen KW - Catalase KW - planktonic cells KW - Gene expression KW - Flight KW - Hydrogen peroxide KW - Lipoproteins KW - Lasers KW - Biofilms KW - Pseudomonas aeruginosa KW - Alkyl hydroperoxide reductase KW - carbonyls KW - Oxidants KW - W 30950:Waste Treatment & Pollution Clean-up KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20883954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+Peptidoglycan-Associated+Lipoprotein+OprL+Helps+Protect+a+Pseudomonas+aeruginosa+Mutant+Devoid+of+the+Transactivator+OxyR+from+Hydrogen+Peroxide-Mediated+Killing+during+Planktonic+and+Biofilm+Culture&rft.au=Panmanee%2C+Warunya%3BGomez%2C+Francisco%3BWitte%2C+David%3BPancholi%2C+Vijay%3BBritigan%2C+Bradley+E%3BHassett%2C+Daniel+J&rft.aulast=Panmanee&rft.aufirst=Warunya&rft.date=2008-05-01&rft.volume=190&rft.issue=10&rft.spage=3658&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Antioxidants; Transmission electron microscopy; Outer membranes; Survival; Enzymes; Cell culture; Hydrogen; planktonic cells; Catalase; Flight; Gene expression; Hydrogen peroxide; Lipoproteins; Lasers; Biofilms; carbonyls; Alkyl hydroperoxide reductase; Oxidants; Pseudomonas aeruginosa ER - TY - JOUR T1 - Potentiation of noise-induced healing loss by aviation fuel exposure in rats AN - 20808854; 10958982 AB - Clear standards have been established for workplace noise. These are designed to protect workers against noise-induced hearing loss. That occupational hearing loss still occurs despite such standards may reflect a variety of issues ranging from enforcement of standards, to adequacy of standards, and problems of noise assessment. An additional factor that influences susceptibility to noise-induced hearing loss is the presence of chemical contaminants in the workplace that render the auditory system especially vulnerable to noise. We report on the ability of aviation fuels to potentiate noise-induced hearing loss in laboratory rats. Subjects were exposed to JP-8 jet fuel, a synthetic fuel produced from coal using the Fischer-Tropsch method, or to clean air. Half of the subjects received a moderate noise exposure following fuel or air exposure. The noise exposure was designed to produce a temporary threshold shift. JP-8 + noise produced greater disruption of distortion product otoacoustic emissions as well as the auditory threshold than did noise alone. JF - Journal of the Acoustical Society of America AU - Fechter, L D AU - Gearhart, CA AU - Fulton, S AU - Kim, Y H AD - Loma Linda VA Medical Center, Research Service (151), 11201 Benton Street, Loma Linda, CA 92357, USA, larry.fechter@va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 VL - 123 IS - 5 SN - 0001-4966, 0001-4966 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Workers KW - otoacoustic emissions KW - Auditory system KW - Fuels KW - Potentiation KW - Noise KW - Hearing loss KW - Coal KW - Contaminants KW - N3 11027:Neurology & neuropathology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20808854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Acoustical+Society+of+America&rft.atitle=Potentiation+of+noise-induced+healing+loss+by+aviation+fuel+exposure+in+rats&rft.au=Fechter%2C+L+D%3BGearhart%2C+CA%3BFulton%2C+S%3BKim%2C+Y+H&rft.aulast=Fechter&rft.aufirst=L&rft.date=2008-05-01&rft.volume=123&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Workers; otoacoustic emissions; Auditory system; Potentiation; Fuels; Noise; Coal; Hearing loss; Contaminants ER - TY - JOUR T1 - Facilitating Clinical Outcomes Assessment through the Automated Identification of Quality Measures for Prostate Cancer Surgery AN - 20674902; 8199214 AB - OBJECTIVES: The College of American Pathologists (CAP) Category 1 quality measures, tumor stage, Gleason score, and surgical margin status, are used by physicians and cancer registrars to categorize patients into groups for clinical trials and treatment planning. This study was conducted to evaluate the effectiveness of an application designed to automatically extract these quality measures from the postoperative pathology reports of patients having undergone prostatectomies for treatment of prostate cancer. DESIGN: An application was developed with the Clinical Outcomes Assessment Toolkit that uses an information pipeline of regular expressions and support vector machines to extract CAP Category 1 quality measures. System performance was evaluated against a gold standard of 676 pathology reports from the University of California at Los Angeles Medical Center and Brigham and Women's Hospital. To evaluate the feasibility of clinical implementation, all pathology reports were gathered using administrative codes with no manual preprocessing of the data performed. MEASUREMENTS: The sensitivity, specificity, and overall accuracy of system performance were measured for all three quality measures. Performance at both hospitals was compared, and a detailed failure analysis was conducted to identify errors caused by poor data quality versus system shortcomings. RESULTS: Accuracies for Gleason score were 99.7%, tumor stage 99.1%, and margin status 97.2%, for an overall accuracy of 98.67%. System performance on data from both hospitals was comparable. Poor clinical data quality led to a decrease in overall accuracy of only 0.3% but accounted for 25.9% of the total errors. CONCLUSION: Despite differences in document format and pathologists' reporting styles, strong system performance indicates the potential of using a combination of regular expressions and support vector machines to automatically extract CAP Category 1 quality measures from postoperative prostate cancer pathology reports. JF - Journal of the American Medical Informatics Association AU - D'Avolio, Leonard W AU - Litwin, Mark S AU - Rogers, Selwyn OJr AU - Bui, Alex AT AD - Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Veterans Administration Hospital, Boston, MA. The Graduate Program in Health Informatics, College of Computer and Information Science and the Bouve College of Health Sciences, Northeastern University, Boston, MA. Departments of Urology and Health Services, University of California, Los Angeles, CA. Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA. Medical Imaging Informatics Group, University of California, Los Angeles, CA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 341 EP - 348 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 15 IS - 3 SN - 1067-5027, 1067-5027 KW - Biotechnology Research Abstracts (through 1992) KW - Prostate cancer KW - Data processing KW - Surgery KW - Tumors KW - Clinical trials KW - Styles KW - Hospitals KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20674902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Facilitating+Clinical+Outcomes+Assessment+through+the+Automated+Identification+of+Quality+Measures+for+Prostate+Cancer+Surgery&rft.au=D%27Avolio%2C+Leonard+W%3BLitwin%2C+Mark+S%3BRogers%2C+Selwyn+OJr%3BBui%2C+Alex+AT&rft.aulast=D%27Avolio&rft.aufirst=Leonard&rft.date=2008-05-01&rft.volume=15&rft.issue=3&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Data processing; Hospitals; Prostate cancer; Tumors; Styles; Clinical trials; Surgery ER - TY - JOUR T1 - The Clinical Outcomes Assessment Toolkit: A Framework to Support Automated Clinical Records-based Outcomes Assessment and Performance Measurement Research AN - 20671361; 8199213 AB - The Clinical Outcomes Assessment Toolkit (COAT) was created through a collaboration between the University of California, Los Angeles and Brigham and Women's Hospital to address the challenge of gathering, formatting, and abstracting data for clinical outcomes and performance measurement research. COAT provides a framework for the development of information pipelines to transform clinical data from its original structured, semi-structured, and unstructured forms to a standardized format amenable to statistical analysis. This system includes a collection of clinical data structures, reusable utilities for information analysis and transformation, and a graphical user interface through which pipelines can be controlled and their results audited by nontechnical users. The COAT architecture is presented, as well as two case studies of current implementations in the domain of prostate cancer outcomes assessment. JF - Journal of the American Medical Informatics Association AU - D'Avolio, Leonard W AU - Bui, Alex AT AD - Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Veterans Administration Hospital, Boston, MA. The Graduate Program in Health Informatics, College of Computer and Information Science and the Bouve College of Health Sciences, Northeastern University, Boston, MA. Medical Imaging Informatics Group, University of California, Los Angeles, CA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 333 EP - 340 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 15 IS - 3 SN - 1067-5027, 1067-5027 KW - Biotechnology Research Abstracts (through 1992) KW - Transformation KW - Prostate cancer KW - Statistical analysis KW - Hospitals KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20671361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=The+Clinical+Outcomes+Assessment+Toolkit%3A+A+Framework+to+Support+Automated+Clinical+Records-based+Outcomes+Assessment+and+Performance+Measurement+Research&rft.au=D%27Avolio%2C+Leonard+W%3BBui%2C+Alex+AT&rft.aulast=D%27Avolio&rft.aufirst=Leonard&rft.date=2008-05-01&rft.volume=15&rft.issue=3&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Statistical analysis; Hospitals; Prostate cancer; Transformation ER - TY - JOUR T1 - Comparison of Cutaneous and Transosseous Electromagnetic Position Sensors in the Assessment of Tibial Rotation in a Cadaveric Model AN - 20071394; 10094926 AB - Background: Recent studies have highlighted the growing interest in validating anatomic anterior cruciate ligament reconstructions. A simple method of measuring tibial rotation is necessary to provide an objective clinical assessment of restoration of normal knee kinematics after various anterior cruciate ligament reconstructive techniques.Objective: To validate a new method of measuring tibial rotation by comparing cutaneous with transosseous electromagnetic position sensors during a simulated standard knee examination.Study Design: Controlled laboratory study.Methods: Eight thawed, fresh-frozen cadaveric knee specimens with skin and soft tissues preserved were mounted on the femoral side in neutral rotation by a rigid clamp, allowing 6 degrees of freedom of the knee joint. With the knee fixed at 30 degree of flexion, a series of maximal manual internal and external tibial rotations were performed and measured with an electromagnetic tracking system that measures 6 degrees of freedom in a Cartesian coordinate system. During each series of measurements, a cutaneous transmitter was fixed overlying the tibial tuberosity. Simultaneously, a second transducer was rigidly fixed to a transosseous pin placed just distal to the tibial tubercle. Measurements were repeated at 90 degree of flexion. Differences in measurements were assessed.Results: No significant differences were found with maximal internal and external rotation between cutaneous and transosseous measurements at 30 degree of knee flexion (13.0 degree vs 14.5 degree , P = .4) or at 90 degree of flexion (11.2 degree vs 12.9 degree , P = .5). Correlation (R) between cutaneous and transosseous measurements at 30 degree was .97 (P = .00009) and at 90 degree was .99 (P < .00001). The accuracy of cutaneous measurements using transosseous as the known was 1.6 degree plus or minus 1.3 degree . Repeatability of cutaneous measurements was 0.8 degree plus or minus 0.4 degree . The repeatability of transosseous measurements was 1.0 degree plus or minus 0.5 degree .Conclusion: No significant differences were found at either 30 degree or 90 degree of flexion when measuring tibial rotation using cutaneous versus transosseous electromagnetic position sensors.Clinical Relevance: The ability to measure knee rotation using cutaneous electromagnetic position sensors represents a promising new method for assessing various clinical conditions and surgical outcomes. JF - American Journal of Sports Medicine AU - Magit, David P AU - McGarry, Michelle AU - Tibone, James E AU - Lee, Thay Q AD - Kerlan Jobe Orthopaedic Clinic, Los Angeles, California, tqlee@med.va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 971 EP - 977 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 36 IS - 5 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Evaluation KW - Measurement KW - Kinematics KW - Ligaments KW - Skin KW - Knees KW - Techniques KW - Sports medicine KW - Joints KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20071394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Comparison+of+Cutaneous+and+Transosseous+Electromagnetic+Position+Sensors+in+the+Assessment+of+Tibial+Rotation+in+a+Cadaveric+Model&rft.au=Magit%2C+David+P%3BMcGarry%2C+Michelle%3BTibone%2C+James+E%3BLee%2C+Thay+Q&rft.aulast=Magit&rft.aufirst=David&rft.date=2008-05-01&rft.volume=36&rft.issue=5&rft.spage=971&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F0363546507312639 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Evaluation; Kinematics; Measurement; Ligaments; Skin; Knees; Techniques; Sports medicine; Joints DO - http://dx.doi.org/10.1177/0363546507312639 ER - TY - JOUR T1 - Elbow Valgus Laxity May Result in an Overestimation of Apparent Shoulder External Rotation During Physical Examination AN - 20056561; 10094931 AB - Background: The contributions of the scapulothoracic articulation and spine when measuring shoulder range of motion have been well described; however, the effect of elbow valgus laxity has not.Hypothesis: Increased elbow valgus laxity affects the assessment of shoulder external rotation measured during physical examination at 90 degree of elbow flexion.Study Design: Controlled laboratory study.Methods: Seven cadaveric upper extremities were tested with an elbow valgus laxity-testing device. Shoulder external rotation was assessed with 2.8 N.m of external torque by measuring a change in the angle of the forearm axis at 90 degree of elbow flexion. Elbow valgus laxity was measured in degrees of valgus angulation with 1.5 N.m of valgus torque with the humerus fixed. Shoulder external rotation and elbow valgus laxity were recorded at each of the following conditions: (1) intact, (2) after splitting the pronator muscles and venting the capsule, (3) after cutting the posterior band of the anterior oblique ligament of the ulnar collateral ligament, and (4) after cutting the anterior oblique ligament completely.Results: After the posterior band of the anterior oblique ligament of the ulnar collateral ligament was cut, apparent shoulder external rotation and elbow valgus laxity were increased by 4.1 degree plus or minus 1.7 degree (P < .01) and 3.1 degree plus or minus 1.3 degree (P < .001), respectively, when compared with the intact condition. Complete cutting of the anterior oblique ligament resulted in an apparent increased shoulder external rotation and an increased elbow valgus laxity of 11.0 degree plus or minus 1.1 degree ( P < .001) and 9.1 degree plus or minus 1.2 degree (P < .001), respectively, when compared with the intact condition.Conclusion: Shoulder external rotation as assessed by physical examination, which was defined as the angle of the forearm axis, as well as elbow valgus laxity, was significantly increased after the anterior oblique ligament of the ulnar collateral ligament was cut, although the glenohumeral joint condition was not changed.Clinical Relevance: Elbow valgus laxity may cause an overestimation of shoulder external rotation on clinical examination of the shoulder. JF - American Journal of Sports Medicine AU - Mihata, Teruhisa AU - Safran, Marc R AU - McGarry, Michelle H AU - Abe, Muneaki AU - Lee, Thay Q AD - Orthopaedic Biomechanics Laboratory, VA Long Beach Healthcare System, Long Beach, California, University of California, Irvine, California, Osaka Medical College, Department of Orthopaedic Surgery, Takatsuki, Japan, tqlee@med.va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 978 EP - 982 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 36 IS - 5 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Evaluation KW - Force KW - Medical examinations KW - Measurement KW - Ligaments KW - Elbows KW - Flexibility KW - Shoulders KW - Arms KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20056561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Elbow+Valgus+Laxity+May+Result+in+an+Overestimation+of+Apparent+Shoulder+External+Rotation+During+Physical+Examination&rft.au=Mihata%2C+Teruhisa%3BSafran%2C+Marc+R%3BMcGarry%2C+Michelle+H%3BAbe%2C+Muneaki%3BLee%2C+Thay+Q&rft.aulast=Mihata&rft.aufirst=Teruhisa&rft.date=2008-05-01&rft.volume=36&rft.issue=5&rft.spage=978&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F0363546507313086 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Force; Evaluation; Measurement; Medical examinations; Ligaments; Elbows; Flexibility; Shoulders; Arms DO - http://dx.doi.org/10.1177/0363546507313086 ER - TY - JOUR T1 - Statin and Stromal Cell-Derived Factor-1 Additively Promote Angiogenesis by Enhancement of Progenitor Cells Incorporation into New Vessels AN - 20049701; 8305110 AB - Angiogenesis requires the mobilization of progenitor cells from the bone marrow and homing of progenitor cells to ischemic tissue. Statins facilitate the former, and the chemokine stromal cell-derived factor-1 (SDF-1) enhances the latter. Their combined influence on angiogenesis was studied in vivo in the ischemic hindlimb C57BL/6 mouse model. The ischemic to non-ischemic perfusion ratio increased from 0.29 plus or minus 0.02 immediately after femoral excision to 0.51 plus or minus 0.10 three weeks after the surgery in the mice treated with either fluvastatin or SDF-1 alone, which is significantly better than the control (0.38 plus or minus 0.05, p < .05, n = 6). The combined use of fluvastatin and SDF-1 further improved the reperfusion ratio (0.62 plus or minus 0.08, p < .05). More cell proliferation, less apoptosis, enhanced bone marrow-derived endothelial progenitor cell (EPC) incorporation and higher capillary density were observed in ischemic tissue treated with both statin and SDF-1. In vitro mono-treatment with either fluvastatin (100 nM) or SDF-1 (100 ng/ml) facilitated EPC proliferation and migration, inhibited EPC apoptosis, enhanced expression of matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9), and increased Akt phosphorylation and nitric oxide production. These effects were significantly augmented by the two agents together and ablated by inhibitors of either Akt or nitric oxide synthase (NOS). In conclusion, statin and SDF-1 additively enhance progenitor cell migration and proliferation and down-regulate EPC apoptosis, resulting in improved reperfusion via activation of the Akt/NOS pathway and up-regulation of MMP-2 and MMP-9 expression. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Shao, Hongwei AU - Tan, Yaohong AU - Eton, Darwin AU - Yang, Zhe AU - Uberti, MGeorgina AU - Li, Sen AU - Schulick, Andrew AU - Yu, Hong AD - Department of Surgery, Vascular Biology Institute, University of Miami, Miller School of Medicine, Miami, Florida, USA. Division of Vascular Surgery, Miami Veterans Administration, Miami, Florida, USA. Baptist Cardiac and Vascular Institute, Miami, Florida, USA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1376 EP - 1384 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 26 IS - 5 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - SDF-1 protein KW - Chemokines KW - Apoptosis KW - Perfusion KW - fluvastatin KW - Bone marrow KW - Angiogenesis KW - Animal models KW - statins KW - Ischemia KW - Femur KW - Nitric-oxide synthase KW - Reperfusion KW - Stem cells KW - Phosphorylation KW - Surgery KW - AKT protein KW - Osteoprogenitor cells KW - Gelatinase A KW - Nitric oxide KW - Gelatinase B KW - Cell migration KW - Cell proliferation KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20049701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Statin+and+Stromal+Cell-Derived+Factor-1+Additively+Promote+Angiogenesis+by+Enhancement+of+Progenitor+Cells+Incorporation+into+New+Vessels&rft.au=Shao%2C+Hongwei%3BTan%2C+Yaohong%3BEton%2C+Darwin%3BYang%2C+Zhe%3BUberti%2C+MGeorgina%3BLi%2C+Sen%3BSchulick%2C+Andrew%3BYu%2C+Hong&rft.aulast=Shao&rft.aufirst=Hongwei&rft.date=2008-05-01&rft.volume=26&rft.issue=5&rft.spage=1376&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - SDF-1 protein; Chemokines; Perfusion; Apoptosis; fluvastatin; Animal models; Angiogenesis; Bone marrow; statins; Ischemia; Femur; Reperfusion; Nitric-oxide synthase; Stem cells; Phosphorylation; Surgery; Osteoprogenitor cells; AKT protein; Nitric oxide; Gelatinase A; Cell migration; Gelatinase B; Cell proliferation ER - TY - JOUR T1 - Sexual Harassment Experiences and Harmful Alcohol Use in a Military Sample: Differences in Gender and the Mediating Role of Depression AN - 19582821; 8228829 AB - Objective: Researchers and clinicians alike are interested in the effects of sexual harassment on mental health, including associations with problem drinking. The aim of the current investigation was to examine depression symptoms as a mediator of the association between sexual harassment during military service and current harmful alcohol use in a sample of former military personnel, stratified by gender. Method: Using a cross-sectional design, 3,946 former reservists were surveyed regarding their experiences of sexual harassment in the military and their current depression symptoms and harmful alcohol use. Fifty-nine percent of the final sample were female. Results: As expected, women endorsed experiencing sexual harassment more than men, and men endorsed harmful drinking more than women. Sexual harassment was associated with increased depression symptoms among both men and women; however, depression symptoms mediated the association between sexual harassment and harmful alcohol use among women only. Sexual harassment was not a significant predictor of harmful alcohol use among men. Conclusions: The associations between sexual harassment, depression symptoms, and harmful alcohol use differ between men and women in this sample. Consistent with the self-medication hypothesis, sexual harassment is associated with harmful drinking among women, and this association can be accounted for by symptoms of depression. The high prevalence of harmful drinking among men and the lack of an association with sexual harassment suggest that, in this sample, men's harmful drinking is influenced by fectors other than sexual harassment. JF - Journal of Studies on Alcohol and Drugs AU - Gradus, J L AU - Street, A E AU - Kelly, K AU - Stafford, J AD - National Center for Posttraumatic Stress Disorder, Veterans Affairs Boston Healthcare System, Women's Health Sciences Division (116B-3), 150 South Huntington Avenue, Boston, Massachusetts 02130, USA, Amy.Street@va.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 348 EP - 351 VL - 69 IS - 3 SN - 1937-1888, 1937-1888 KW - Health & Safety Science Abstracts KW - Alcohol KW - depression KW - Gender KW - Military KW - Sexual harassment KW - Substance abuse KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19582821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Sexual+Harassment+Experiences+and+Harmful+Alcohol+Use+in+a+Military+Sample%3A+Differences+in+Gender+and+the+Mediating+Role+of+Depression&rft.au=Gradus%2C+J+L%3BStreet%2C+A+E%3BKelly%2C+K%3BStafford%2C+J&rft.aulast=Gradus&rft.aufirst=J&rft.date=2008-05-01&rft.volume=69&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Sexual harassment; Alcohol; Substance abuse; depression; Military; Gender; Occupational health ER - TY - CPAPER T1 - Cyclooxygenase/Lipoxygenase Dual Inhibitor Licofelone Inhibits Growth of Human Bladder Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864227; 4820792 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Gee, Jason R AU - Burmeister, Corrie B Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Prostaglandin-endoperoxide synthase KW - Urinary bladder KW - Lipoxygenase KW - Inhibitors KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Cyclooxygenase%2FLipoxygenase+Dual+Inhibitor+Licofelone+Inhibits+Growth+of+Human+Bladder+Cancer&rft.au=Gee%2C+Jason+R%3BBurmeister%2C+Corrie+B&rft.aulast=Gee&rft.aufirst=Jason&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bcl-B Expression in Human Epithelial and Non-epithelial Malignancies. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40859535; 4821292 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Krajewska, Maryla AU - Winter, Jane N AU - Variakojis, Daina AU - Lichtenstein, Alan AU - Zhai, Dayong AU - Cuddy, Michael AU - Huang, Xianshu AU - Luciano, Frederic AU - Baker, Cheryl H AU - Kim, Hoguen AU - Shin, Eunah AU - Kennedy, Susan AU - Olson, Allen H AU - Badzio, Andrzej AU - Jassem, Jacek AU - Meinhold-Heerlein, Ivo AU - Duffy, Michael J AU - Schimmer, Aaron D AU - Tsao, Ming AU - Brown, Ewan AU - Mercola, Dan AU - Krajewski, Stan AU - Reed, John C Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Malignancy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Bcl-B+Expression+in+Human+Epithelial+and+Non-epithelial+Malignancies.&rft.au=Krajewska%2C+Maryla%3BWinter%2C+Jane+N%3BVariakojis%2C+Daina%3BLichtenstein%2C+Alan%3BZhai%2C+Dayong%3BCuddy%2C+Michael%3BHuang%2C+Xianshu%3BLuciano%2C+Frederic%3BBaker%2C+Cheryl+H%3BKim%2C+Hoguen%3BShin%2C+Eunah%3BKennedy%2C+Susan%3BOlson%2C+Allen+H%3BBadzio%2C+Andrzej%3BJassem%2C+Jacek%3BMeinhold-Heerlein%2C+Ivo%3BDuffy%2C+Michael+J%3BSchimmer%2C+Aaron+D%3BTsao%2C+Ming%3BBrown%2C+Ewan%3BMercola%2C+Dan%3BKrajewski%2C+Stan%3BReed%2C+John+C&rft.aulast=Krajewska&rft.aufirst=Maryla&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Successful Treatment of HENOCH-Schonlein Purpura Nephritis with Plasma Exchange in an Adult Male T2 - 2008 Spring Clinical Meetings of the National Kidney Foundation (CM 2008) AN - 40920474; 4846284 JF - 2008 Spring Clinical Meetings of the National Kidney Foundation (CM 2008) AU - Shin, Ji Young AU - Singh, Mandeep AU - Chaudhary, Kunal Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 KW - Purpura KW - Nephritis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40920474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Spring+Clinical+Meetings+of+the+National+Kidney+Foundation+%28CM+2008%29&rft.atitle=Successful+Treatment+of+HENOCH-Schonlein+Purpura+Nephritis+with+Plasma+Exchange+in+an+Adult+Male&rft.au=Shin%2C+Ji+Young%3BSingh%2C+Mandeep%3BChaudhary%2C+Kunal&rft.aulast=Shin&rft.aufirst=Ji&rft.date=2008-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Spring+Clinical+Meetings+of+the+National+Kidney+Foundation+%28CM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kidney.org/news/meetings/clinical/CM08_Abstracts.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Review: Endurance exercise and resistance training in cardiovascular disease AN - 807260031; 13619880 AB - Contrary to the age old taboo of exercise in cardiac patients, resistance training has been gaining importance recently as a safe, healthy fitness option in prevention of cardiovascular diseases, the leading killer disease in the population above 45 years in the United States. Endurance or aerobic exercise helps improve overall stamina and the ability of the heart to pump oxygenated blood in those with and without prior cardiovascular disease. In addition to modifying cardiovascular risks, resistance training has profound beneficial effects on improving muscle strength and endurance, preventing osteoporosis and improving quality of life both in the healthy and cardiovascular patients including women and heart failure patients. So resistance training should be regarded as a complementary fitness program rather that a substitute to endurance training. This review discusses the physiological phenomenon and benefits of exercise training programs on cardiovascular disease patients focusing on endurance exercise and resistance training. JF - Therapeutic Advances in Cardiovascular Disease AU - Meka, Naga AU - Katragadda, Srikanth AU - Cherian, Biju AU - Arora, Rohit R AD - Department of Cardiology, Rosalind Franklin University, Chicago Medical School, rohit.arora@va.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 115 EP - 121 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 2 IS - 2 SN - 1753-9447, 1753-9447 KW - Physical Education Index KW - Heart KW - Muscular endurance KW - Endurance KW - Failure KW - Cardiorespiratory KW - Patients KW - Resistance exercise KW - Diseases KW - Exercise (programs) KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807260031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+Advances+in+Cardiovascular+Disease&rft.atitle=Review%3A+Endurance+exercise+and+resistance+training+in+cardiovascular+disease&rft.au=Meka%2C+Naga%3BKatragadda%2C+Srikanth%3BCherian%2C+Biju%3BArora%2C+Rohit+R&rft.aulast=Meka&rft.aufirst=Naga&rft.date=2008-04-01&rft.volume=2&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Therapeutic+Advances+in+Cardiovascular+Disease&rft.issn=17539447&rft_id=info:doi/10.1177%2F1753944708089701 LA - English DB - Physical Education Index N1 - Date revised - 2010-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Heart; Muscular endurance; Failure; Endurance; Patients; Cardiorespiratory; Diseases; Resistance exercise; Exercise (programs) DO - http://dx.doi.org/10.1177/1753944708089701 ER - TY - JOUR T1 - Clinical practice algorithms: medication management to reduce fall risk in the elderly-part 4, anticoagulants, anticonvulsants, anticholinergics/bladder relaxants, and antipsychotics. AN - 70468670; 18387014 JF - Journal of the American Academy of Nurse Practitioners AU - Bulat, Tatjana AU - Castle, Steven Charles AU - Rutledge, Michelle AU - Quigley, Patricia AD - VISN 8 Patient Safety Center, Tampa, Florida, USA. tatjana.bulat@va.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 181 EP - 190 VL - 20 IS - 4 SN - 1041-2972, 1041-2972 KW - Anticoagulants KW - 0 KW - Anticonvulsants KW - Antipsychotic Agents KW - Cholinergic Antagonists KW - Nursing KW - Evidence-Based Medicine KW - Humans KW - Aged KW - Patient Selection KW - Primary Health Care -- organization & administration KW - Geriatric Assessment KW - Geriatric Nursing -- organization & administration KW - Risk Assessment KW - Patient Education as Topic KW - Nursing Assessment KW - Risk Factors KW - Decision Trees KW - Nurse Practitioners KW - Polypharmacy KW - Practice Guidelines as Topic KW - Safety Management -- organization & administration KW - Anticoagulants -- therapeutic use KW - Antipsychotic Agents -- therapeutic use KW - Anticoagulants -- adverse effects KW - Anticonvulsants -- adverse effects KW - Algorithms KW - Accidental Falls -- prevention & control KW - Cholinergic Antagonists -- therapeutic use KW - Cholinergic Antagonists -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Anticonvulsants -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70468670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Nurse+Practitioners&rft.atitle=Clinical+practice+algorithms%3A+medication+management+to+reduce+fall+risk+in+the+elderly-part+4%2C+anticoagulants%2C+anticonvulsants%2C+anticholinergics%2Fbladder+relaxants%2C+and+antipsychotics.&rft.au=Bulat%2C+Tatjana%3BCastle%2C+Steven+Charles%3BRutledge%2C+Michelle%3BQuigley%2C+Patricia&rft.aulast=Bulat&rft.aufirst=Tatjana&rft.date=2008-04-01&rft.volume=20&rft.issue=4&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Nurse+Practitioners&rft.issn=10412972&rft_id=info:doi/10.1111%2Fj.1745-7599.2008.00311.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-26 N1 - Date created - 2008-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1745-7599.2008.00311.x ER - TY - JOUR T1 - Effects of additive therapy with spironolactone on proteinuria in diabetic patients already on ACE inhibitor or ARB therapy: results of a randomized, placebo-controlled, double-blind, crossover trial. AN - 70461803; 18382267 AB - Aldosterone seems to have deleterious effects on the kidneys. Many animal studies and a few clinical trials have shown that suppression of aldosteroneby aldosterone receptor blockers ameliorates these effects. In a double-blind crossover study, patients with diabetic nephropathy who were already receiving either angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) were given spironolactone or matching placebo with 1 month of washout in between. Blood pressure (BP), serum creatinine, serum potassium, and spot urine protein/creatinine were measured at the beginning and end of each study period. Mean systolic BP on spironolactone went down from 153.64 (+/-25.95) at the beginning to 141.60 (+/-16.54) at the end of study (P = 0.01). Diastolic BP during spironolactone therapy did not change significantly. The urine protein/creatinine increased from 1.24 (+/-1.13) to 1.57 (+/-2.13) on placebo (P = 0.35) and decreased from 1.80 (+/-1.78) to 0.79 (+/-0.99) during spironolactone therapy (P = 0.004). In other words proteinuria increased by 24% during the placebo treatment period but decreased by half (57%) during the active treatment. Serum potassium increased from 4.29 (+/-0.47) to 4.64 (+/-0.55) during spironolactone therapy (P = 0.002), no significant change with placebo. Whereas serum creatinine did not change on placebo, it increased from 1.35 (+/-0.54) to 1.56 (+/-0.62) on spironolactone (P = 0.006). Glomerular filtration rate decreased from 61.91 (+/-23.4) to 53.94 (+/-23.58) on spironolactone (P = 0.0001) but not on placebo. Addition of a modest dose of spironolactone to a regimen of ACEI or ARB in patients with diabetic proteinuria causes further reduction in proteinuria and also lowers the systolic BP. As with ACEI or ARB, spironolactone modestly reduces the glomerular filtration rate and raises serum potassium. JF - Journal of investigative medicine : the official publication of the American Federation for Clinical Research AU - Saklayen, Mohammad G AU - Gyebi, Leonard K AU - Tasosa, Joseph AU - Yap, Jayson AD - VA Medical Center, Dayton, OH 45428, USA. mohammad.saklayen@va.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 714 EP - 719 VL - 56 IS - 4 SN - 1081-5589, 1081-5589 KW - Angiotensin II Type 1 Receptor Blockers KW - 0 KW - Angiotensin-Converting Enzyme Inhibitors KW - Spironolactone KW - 27O7W4T232 KW - Glucosephosphate Dehydrogenase KW - EC 1.1.1.49 KW - Index Medicus KW - Glucosephosphate Dehydrogenase -- blood KW - Double-Blind Method KW - Humans KW - Glomerular Filtration Rate -- drug effects KW - Cross-Over Studies KW - Middle Aged KW - Blood Pressure -- drug effects KW - Drug Synergism KW - Male KW - Angiotensin-Converting Enzyme Inhibitors -- therapeutic use KW - Spironolactone -- therapeutic use KW - Proteinuria -- drug therapy KW - Angiotensin II Type 1 Receptor Blockers -- therapeutic use KW - Diabetic Nephropathies -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70461803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+investigative+medicine+%3A+the+official+publication+of+the+American+Federation+for+Clinical+Research&rft.atitle=Effects+of+additive+therapy+with+spironolactone+on+proteinuria+in+diabetic+patients+already+on+ACE+inhibitor+or+ARB+therapy%3A+results+of+a+randomized%2C+placebo-controlled%2C+double-blind%2C+crossover+trial.&rft.au=Saklayen%2C+Mohammad+G%3BGyebi%2C+Leonard+K%3BTasosa%2C+Joseph%3BYap%2C+Jayson&rft.aulast=Saklayen&rft.aufirst=Mohammad&rft.date=2008-04-01&rft.volume=56&rft.issue=4&rft.spage=714&rft.isbn=&rft.btitle=&rft.title=Journal+of+investigative+medicine+%3A+the+official+publication+of+the+American+Federation+for+Clinical+Research&rft.issn=10815589&rft_id=info:doi/10.2310%2FJIM.0b013e31816d78e9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-09 N1 - Date created - 2008-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2310/JIM.0b013e31816d78e9 ER - TY - JOUR T1 - Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury. AN - 70449253; 18349119 AB - Mutation of the adult hepatocyte keratins K8 and K18 predisposes to liver disease. In contrast, exocrine pancreas K8 and K18 are dispensable and are co-expressed with limited levels of membrane-proximal K19 and K20. Overexpression of mutant K18 or genetic ablation of K8 in mouse pancreas is well tolerated whereas overexpression of K8 causes spontaneous chronic pancreatitis. To better understand the effect of exocrine pancreatic keratin overexpression, we compared transgenic mice that overexpress K18, K8, or K8/K18, associated with minimal, modest, or large increases in keratin expression, respectively, with nontransgenic wild-type (WT) mice. Overexpression of the type-II keratin K8 up-regulated type-I keratins K18, K19, and K20 and generated K19/K20-containing neocytoplasmic typical or short filaments; however, overexpression of K18 had no effect on K8 levels. K8- and K18-overexpressing pancreata were histologically similar to WT, whereas K8/K18 pancreata displayed age-enhanced vacuolization and atrophy of the exocrine pancreas and exhibited keratin hyperphosphorylation. Zymogen granules in K8/K18 pancreata were 50% smaller and more dispersed than their normal apical concentration but were twice as numerous as in WT controls. Therefore, modest keratin overexpression has minor effects on the exocrine pancreas whereas significant keratin overexpression alters zymogen granule organization and causes aging-associated exocrine atrophy. Keratin absence or mutation is well tolerated after pancreatic but not liver injury, whereas excessive overexpression is toxic to the pancreas but not the liver when induced under basal conditions. JF - The American journal of pathology AU - Toivola, Diana M AU - Nakamichi, Ikuo AU - Strnad, Pavel AU - Michie, Sara A AU - Ghori, Nafisa AU - Harada, Masaru AU - Zeh, Karin AU - Oshima, Robert G AU - Baribault, Helene AU - Omary, M Bishr AD - Department of Medicine, Veterans Administration Palo Alto Health Care System, Palo Alto, CA, USA. dtoivola@abo.fi Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 882 EP - 892 VL - 172 IS - 4 SN - 0002-9440, 0002-9440 KW - Keratin-18 KW - 0 KW - Keratin-19 KW - Keratin-8 KW - RNA, Messenger KW - Keratins KW - 68238-35-7 KW - Amylases KW - EC 3.2.1.- KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Secretory Vesicles -- ultrastructure KW - Keratin-19 -- genetics KW - Humans KW - Liver -- metabolism KW - Mice, Transgenic KW - RNA, Messenger -- genetics KW - Keratin-8 -- metabolism KW - Phosphorylation KW - Amylases -- metabolism KW - Secretory Vesicles -- metabolism KW - Pancreas, Exocrine -- pathology KW - Gene Expression Regulation KW - Keratin-19 -- metabolism KW - Keratin-18 -- metabolism KW - Fluorescent Antibody Technique KW - Intermediate Filaments -- metabolism KW - Liver -- pathology KW - Keratin-18 -- genetics KW - Mice KW - Keratin-8 -- genetics KW - RNA, Messenger -- metabolism KW - Mutation -- genetics KW - Atrophy KW - Pancreas, Exocrine -- enzymology KW - Pancreas, Exocrine -- ultrastructure KW - Keratins -- metabolism KW - Keratins -- genetics KW - Pancreatic Diseases -- pathology KW - Pancreatic Diseases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70449253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=Keratin+overexpression+levels+correlate+with+the+extent+of+spontaneous+pancreatic+injury.&rft.au=Toivola%2C+Diana+M%3BNakamichi%2C+Ikuo%3BStrnad%2C+Pavel%3BMichie%2C+Sara+A%3BGhori%2C+Nafisa%3BHarada%2C+Masaru%3BZeh%2C+Karin%3BOshima%2C+Robert+G%3BBaribault%2C+Helene%3BOmary%2C+M+Bishr&rft.aulast=Toivola&rft.aufirst=Diana&rft.date=2008-04-01&rft.volume=172&rft.issue=4&rft.spage=882&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=00029440&rft_id=info:doi/10.2353%2Fajpath.2008.070830 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-14 N1 - Date created - 2008-03-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hepatology. 2005 Mar;41(3):517-25 [15726665] Mol Biol Cell. 2007 Dec;18(12):4969-78 [17898082] Pancreatology. 2006;6(1-2):103-8 [16327287] J Cell Biol. 2006 Jul 3;174(1):115-25 [16818723] Trends Biochem Sci. 2006 Jul;31(7):383-94 [16782342] J Mol Med (Berl). 2006 Dec;84(12):1015-22 [17039343] Exp Cell Res. 2007 Jun 10;313(10):2121-33 [17467691] Methods Mol Biol. 2007;360:203-51 [17172732] Exp Cell Res. 2007 Jan 1;313(1):179-94 [17112511] Gastroenterology. 2007 Apr;132(4):1515-26 [17408647] Gastroenterology. 2007 Apr;132(4):1557-73 [17466744] Exp Cell Res. 2007 Jun 10;313(10):2021-32 [17434482] Exp Cell Res. 2007 Jun 10;313(10):2110-20 [17451679] Exp Cell Res. 2007 Jun 10;313(10):2134-43 [17466974] Exp Cell Res. 2000 Mar 15;255(2):156-70 [10694432] J Cell Biol. 2000 May 1;149(3):547-52 [10791969] J Cell Biol. 2000 Oct 30;151(3):563-72 [11062258] Am J Physiol Gastrointest Liver Physiol. 2000 Dec;279(6):G1343-54 [11093958] Curr Opin Cell Biol. 2002 Feb;14(1):110-22 [11792552] Biochem J. 2002 Mar 1;362(Pt 2):433-42 [11853552] Cell Death Differ. 2002 May;9(5):486-92 [11973607] Hepatology. 2003 May;37(5):1006-14 [12717381] Mol Biol Cell. 2003 Jul;14(7):2959-71 [12857878] Dig Liver Dis. 2003 Jun;35(6):416-20 [12868678] J Cell Sci. 2004 Apr 1;117(Pt 9):1709-19 [15075232] Exp Cell Res. 2004 Oct 1;299(2):404-14 [15350539] Dev Cell. 2004 Sep;7(3):359-71 [15363411] J Clin Pathol. 2004 Oct;57(10):1106-10 [15452172] J Pathol. 2004 Nov;204(4):367-76 [15495250] J Mol Biol. 1984 Sep 15;178(2):365-88 [6208369] Mol Cell Biol. 1989 Apr;9(4):1553-65 [2471065] J Cell Biol. 1990 Sep;111(3):1197-206 [1697294] J Cell Biol. 1994 Oct;127(2):505-20 [7523421] Genes Dev. 1994 Dec 15;8(24):2964-73 [7528156] J Cell Biol. 1995 Dec;131(5):1291-301 [8522590] J Cell Biol. 1995 Dec;131(5):1303-14 [8522591] Ultrastruct Pathol. 1995 Nov-Dec;19(6):495-500 [8597205] J Cell Biol. 1996 Apr;133(2):345-57 [8609167] J Clin Invest. 1996 Aug 15;98(4):1034-46 [8770877] J Pathol. 1998 Mar;184(3):234-9 [9614373] J Clin Invest. 1999 Jun;103(11):1587-95 [10359568] N Engl J Med. 2004 Nov 11;351(20):2087-100 [15537907] J Biol Chem. 2004 Nov 26;279(48):50274-9 [15385539] Methods Cell Biol. 2004;78:489-517 [15646629] Biochem J. 2005 Feb 1;385(Pt 3):721-7 [15462671] Exp Cell Res. 2007 Jun 10;313(10):2077-87 [17498694] Exp Cell Res. 2007 Jun 10;313(10):1995-2009 [17531221] Exp Cell Res. 2007 Jun 10;313(10):2033-49 [17531973] Nat Rev Mol Cell Biol. 2007 Jul;8(7):562-73 [17551517] Genes Dev. 2007 Jul 1;21(13):1581-97 [17606637] Hepatology. 2007 Nov;46(5):1639-49 [17969036] J Cell Biol. 2005 Dec 19;171(6):931-7 [16365160] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2353/ajpath.2008.070830 ER - TY - JOUR T1 - The art of prescribing: pharmacological management of psychosis in Alzheimer's disease: clinical challenges associated with second-generation antipsychotic medications. AN - 70446422; 18366366 JF - Perspectives in psychiatric care AU - Antai-Otong, Deborah AD - Fort Worth Outpatient Clinic, Department of Veterans Affairs in Fort Worth, TX, USA. deborah.antai-otong@va.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 120 EP - 123 VL - 44 IS - 2 SN - 0031-5990, 0031-5990 KW - Antipsychotic Agents KW - 0 KW - Nursing KW - Evidence-Based Medicine KW - Humans KW - Antipsychotic Agents -- administration & dosage KW - Psychotic Disorders -- nursing KW - Antipsychotic Agents -- therapeutic use KW - Alzheimer Disease -- drug therapy KW - Alzheimer Disease -- psychology KW - Psychotic Disorders -- etiology KW - Antipsychotic Agents -- adverse effects KW - Alzheimer Disease -- nursing KW - Psychotic Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70446422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+psychiatric+care&rft.atitle=The+art+of+prescribing%3A+pharmacological+management+of+psychosis+in+Alzheimer%27s+disease%3A+clinical+challenges+associated+with+second-generation+antipsychotic+medications.&rft.au=Antai-Otong%2C+Deborah&rft.aulast=Antai-Otong&rft.aufirst=Deborah&rft.date=2008-04-01&rft.volume=44&rft.issue=2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+psychiatric+care&rft.issn=00315990&rft_id=info:doi/10.1111%2Fj.1744-6163.2008.00161.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-24 N1 - Date created - 2008-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1744-6163.2008.00161.x ER - TY - JOUR T1 - Third-line agent selection for patients with type 2 diabetes mellitus uncontrolled with sulfonylureas and metformin. AN - 70426623; 18363534 AB - Patients with type 2 diabetes mellitus often begin treatment by taking oral agents, usually metformin or a sulfonylurea, and then progress to the combination of these two agents. Most patients often require three or more agents or a change to an insulin regimen. However, no guidelines are available to aid the clinician in the decision-making process for selecting the third agent. Many options are available for additional therapy, including thiazolidinediones, intermediate- and long-acting insulins, exenatide, and dipeptidyl peptidase-4 inhibitors. Although the American Diabetes Association recommends metformin as first-line therapy, it does not give exact specifications for second- and third-line agents but only summarizes clinical data and options about each therapeutic drug class. Guidelines from the American College of Endocrinology and American Association of Clinical Endocrinologists recommend several options depending on the patient's hemoglobin A(1c) level. Therefore, a standard of care cannot be provided; rather, clinicians must evaluate each patient to ascertain that patient's optimum therapy. In doing so, clinicians need to be familiar with the efficacy, safety, and cost of each agent. JF - Pharmacotherapy AU - Edwards, Krystal L AU - Alvarez, Carlos AU - Irons, Brian K AU - Fields, Jessica AD - School of Pharmacy, Texas Tech University Health Sciences Center, Department of Pharmacy Practice, Veterans Administration North Texas Health Care System, Dallas, TX 75216, USA. krystal.edwards@ttuhsc.edu Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 506 EP - 521 VL - 28 IS - 4 SN - 0277-0008, 0277-0008 KW - Dipeptidyl-Peptidase IV Inhibitors KW - 0 KW - Hemoglobin A, Glycosylated KW - Hypoglycemic Agents KW - Insulin KW - Peptides KW - Thiazolidinediones KW - Venoms KW - exenatide KW - 9P1872D4OL KW - Index Medicus KW - Drug Costs KW - Venoms -- therapeutic use KW - Humans KW - Hemoglobin A, Glycosylated -- metabolism KW - Insulin -- analogs & derivatives KW - Practice Guidelines as Topic KW - Insulin -- therapeutic use KW - Dipeptidyl-Peptidase IV Inhibitors -- therapeutic use KW - Thiazolidinediones -- therapeutic use KW - Hemoglobin A, Glycosylated -- drug effects KW - Peptides -- therapeutic use KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Hypoglycemic Agents -- therapeutic use KW - Hypoglycemic Agents -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70426623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Third-line+agent+selection+for+patients+with+type+2+diabetes+mellitus+uncontrolled+with+sulfonylureas+and+metformin.&rft.au=Edwards%2C+Krystal+L%3BAlvarez%2C+Carlos%3BIrons%2C+Brian+K%3BFields%2C+Jessica&rft.aulast=Edwards&rft.aufirst=Krystal&rft.date=2008-04-01&rft.volume=28&rft.issue=4&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/10.1592%2Fphco.28.4.506 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-17 N1 - Date created - 2008-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1592/phco.28.4.506 ER - TY - JOUR T1 - Quetiapine for the treatment of cocaine dependence: an open-label trial. AN - 70410375; 18344735 AB - The monaminergic properties of second generation antipsychotics are prompting research on their use to treat cocaine dependence, with inconclusive results to date. In preliminary reports, the atypical antipsychotic quetiapine has shown promise for the treatment of substance abuse disorders. The primary objective of the current study was to assess the efficacy of quetiapine in reducing cocaine cravings and use in nonpsychotic subjects with cocaine dependence over 6 weeks of open-label treatment. Twenty-two cocaine-dependent, nonpsychotic men were initiated to open-label treatment with quetiapine (300-600 mg/d). The primary outcome measure was weekly self-report of cocaine cravings as assessed with the Brief Substance Craving Scale. Cocaine use was captured with a self-report Timeline Follow-back calendar, administered every 2 weeks. Side effect monitoring was conducted weekly, and movement disorders were assessed every 2 weeks. Intent-to-treat regression analyses (n = 22) indicated that the Brief Substance Craving Scale total score decreased significantly overtime (P < 0.001). Self-reports also suggested decreased cocaine use. There was no treatment-related increase in movement disorders, and most side effects were mild. However, all subjects did experience sedation, and several subjects dropped out because of it. What is more, weight increased significantly over time (P < 0.001). Open-label quetiapine treatment reduced cravings and improved some aspects of cocaine dependence in nonpsychotic individuals. Additional research is needed to confirm the current findings and to further delineate the role quetiapine may play in the treatment of cocaine use disorders. JF - Journal of clinical psychopharmacology AU - Kennedy, Annette AU - Wood, Amanda Ernst AU - Saxon, Andrew J AU - Malte, Carol AU - Harvey, Megan AU - Jurik, Jennifer AU - Kilzieh, Nael AU - Lofgreen, Cassin AU - Tapp, Andre AD - Mental Illness Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA. Annette.Kennedy@va.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 221 EP - 224 VL - 28 IS - 2 SN - 0271-0749, 0271-0749 KW - Antipsychotic Agents KW - 0 KW - Dibenzothiazepines KW - Tablets KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Index Medicus KW - Severity of Illness Index KW - Weight Gain -- drug effects KW - Drug Administration Schedule KW - Antipsychotic Agents -- therapeutic use KW - Humans KW - Syncope -- chemically induced KW - Antipsychotic Agents -- administration & dosage KW - Patient Compliance -- statistics & numerical data KW - Xerostomia -- chemically induced KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Antipsychotic Agents -- adverse effects KW - Time Factors KW - Diagnostic and Statistical Manual of Mental Disorders KW - Male KW - Dibenzothiazepines -- adverse effects KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- drug therapy KW - Dibenzothiazepines -- therapeutic use KW - Dibenzothiazepines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70410375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Quetiapine+for+the+treatment+of+cocaine+dependence%3A+an+open-label+trial.&rft.au=Kennedy%2C+Annette%3BWood%2C+Amanda+Ernst%3BSaxon%2C+Andrew+J%3BMalte%2C+Carol%3BHarvey%2C+Megan%3BJurik%2C+Jennifer%3BKilzieh%2C+Nael%3BLofgreen%2C+Cassin%3BTapp%2C+Andre&rft.aulast=Kennedy&rft.aufirst=Annette&rft.date=2008-04-01&rft.volume=28&rft.issue=2&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/10.1097%2FJCP.0b013e318166f50d LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-27 N1 - Date created - 2008-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/JCP.0b013e318166f50d ER - TY - JOUR T1 - Screening psychiatric patients for illicit drug use disorders and problems. AN - 70391183; 17900773 AB - Illicit drug use is prevalent but under-detected among psychiatric patients. This paper reviews the need for a valid, practical screening instrument for detecting drug problems and disorders among psychiatric patients, and describes the appropriateness of existing screening instruments for this purpose. Research literature on illicit drug screening instruments is reviewed. All existing instruments lack one or more of the following characteristics that would enable them to be used routinely in psychiatric settings: brief and easy to administer, demonstrated validity for male and female psychiatric patients, measuring illicit drug use problems without confounding with alcohol use problems, and assessing drug problems over an optimal timeframe for screening (e.g., past 12 months). Current instruments are not appropriate for routine drug screening of psychiatric patients. A brief, easy to use drug screen should be developed and validated on male and female psychiatric patients for routine screening of drug disorders and problems. JF - Clinical psychology review AU - Tiet, Quyen Q AU - Finney, John W AU - Moos, Rudolf H AD - Department of Veterans Affairs, Stanford University School of Medicine, Menlo Park, CA 94025, USA. Quyen.Tiet@va.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 578 EP - 591 VL - 28 IS - 4 SN - 0272-7358, 0272-7358 KW - Street Drugs KW - 0 KW - Index Medicus KW - Social Behavior Disorders -- diagnosis KW - Social Behavior Disorders -- epidemiology KW - Substance Abuse Detection KW - Humans KW - Alcohol-Related Disorders -- diagnosis KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - Mental Disorders -- epidemiology KW - Mass Screening -- methods KW - Substance-Related Disorders -- epidemiology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70391183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+psychology+review&rft.atitle=Screening+psychiatric+patients+for+illicit+drug+use+disorders+and+problems.&rft.au=Tiet%2C+Quyen+Q%3BFinney%2C+John+W%3BMoos%2C+Rudolf+H&rft.aulast=Tiet&rft.aufirst=Quyen&rft.date=2008-04-01&rft.volume=28&rft.issue=4&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Clinical+psychology+review&rft.issn=02727358&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-24 N1 - Date created - 2008-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sudden onset of diabetic ketoacidosis during consensus interferon therapy for chronic viral hepatitis C. AN - 69105399; 18414077 AB - Interferon (IFN)-alpha, used for the treatment of chronic hepatitis C, has rarely been associated with the development of diabetes. Consensus interferon (CIFN), which is used for nonresponders, has not been associated with this complication. We describe the first case of new onset diabetes in a patient on CIFN. A 50-year-old man with chronic hepatitis C and no prior diabetes was started on IFN-alpha. After 24 weeks with a detectable viral load, he was switched to CIFN. Four weeks later, he presented in diabetic ketoacidosis which resolved with appropriate therapy without any ascertainable etiology (glutamic acid decarboxylase negative). Within 9 months he was off insulin, and is off all diabetic medications with an HgA1c of 5.6% 2 years after the episode. JF - The American journal of the medical sciences AU - Nylen, Eric S AU - Marathe, Ira C AU - Khan, Irfan A AU - Azevedo, Romeu AU - Hirsch, Kenneth R AD - Department of Endocrinology, Veterans Affairs Medical Center, George Washington University Medical Center, Washington, DC 20422, USA. eric.nylen@med.va.Gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 329 EP - 330 VL - 335 IS - 4 SN - 0002-9629, 0002-9629 KW - Interferon Type I KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - interferon alfacon-1 KW - 56588OP40D KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Middle Aged KW - Male KW - Interferon Type I -- adverse effects KW - Hepatitis C, Chronic -- drug therapy KW - Diabetic Ketoacidosis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69105399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Sudden+onset+of+diabetic+ketoacidosis+during+consensus+interferon+therapy+for+chronic+viral+hepatitis+C.&rft.au=Nylen%2C+Eric+S%3BMarathe%2C+Ira+C%3BKhan%2C+Irfan+A%3BAzevedo%2C+Romeu%3BHirsch%2C+Kenneth+R&rft.aulast=Nylen&rft.aufirst=Eric&rft.date=2008-04-01&rft.volume=335&rft.issue=4&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/10.1097%2FMAJ.0b013e318145a721 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-20 N1 - Date created - 2008-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MAJ.0b013e318145a721 ER - TY - JOUR T1 - Glomerular renin angiotensin system in streptozotocin diabetic and Zucker diabetic fatty rats. AN - 68562357; 18355768 AB - Substantial evidence suggests that the intrarenal renin-angiotensin system (RAS) plays a role in the pathogenesis of diabetic nephropathy. Although the glomerular RAS is activated in the streptozotocin (STZ)-diabetic rat, the status of the glomerular RAS in the Zucker diabetic fatty (ZDF) rat, which is a commonly used genetic model of diabetes, is not known. Angiotensinogen (AGT), angiotensin II (Ang II), angiotensin converting enzyme (ACE), and angiotensin converting enzyme 2 (ACE2) were measured in glomeruli isolated from 4-week-old STZ-diabetic rats and 32-week-old ZDF rats. Glomerular injury was evaluated by histopathologic methods. Both STZ-diabetic and ZDF rats exhibited marked hyperglycemia and renal hypertrophy, but only ZDF rats demonstrated proteinuria and glomerulosclerosis. Glomerular AGT and Ang II levels were increased significantly in STZ-diabetic compared with nondiabetic control rats, accompanied by a reduction in ACE2 activity. In contrast, glomerular AGT, Ang II, and ACE2 were similar in ZDF rats and lean controls. ACE levels were not affected by diabetes in either diabetic model. In conclusion, the glomerular RAS is activated in the STZ diabetic rat but not in the ZDF rat despite a similar degree of hyperglycemia. The mechanism of nephropathy in the ZDF rat may involve factors other than hyperglycemia and RAS activation, such as hypertension and hyperlipidemia. JF - Translational research : the journal of laboratory and clinical medicine AU - Leehey, David J AU - Singh, Ashok K AU - Bast, Joseph P AU - Sethupathi, Periannan AU - Singh, Rekha AD - Department of Medicine, Veterans Affairs Hospital, Hines, IL 60141, USA. david.leehey@va.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 208 EP - 216 VL - 151 IS - 4 SN - 1931-5244, 1931-5244 KW - Angiotensinogen KW - 11002-13-4 KW - Streptozocin KW - 5W494URQ81 KW - Peptidyl-Dipeptidase A KW - EC 3.4.15.1 KW - angiotensin converting enzyme 2 KW - EC 3.4.17.- KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Body Weight KW - Animals KW - Rats, Sprague-Dawley KW - Angiotensinogen -- blood KW - Peptidyl-Dipeptidase A -- metabolism KW - Rats, Zucker KW - Organ Size KW - Male KW - Obesity -- metabolism KW - Diabetes Mellitus, Experimental -- genetics KW - Obesity -- genetics KW - Renin-Angiotensin System KW - Kidney Glomerulus -- enzymology KW - Diabetes Mellitus, Experimental -- metabolism KW - Diabetes Mellitus, Experimental -- chemically induced KW - Kidney Glomerulus -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68562357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Translational+research+%3A+the+journal+of+laboratory+and+clinical+medicine&rft.atitle=Glomerular+renin+angiotensin+system+in+streptozotocin+diabetic+and+Zucker+diabetic+fatty+rats.&rft.au=Leehey%2C+David+J%3BSingh%2C+Ashok+K%3BBast%2C+Joseph+P%3BSethupathi%2C+Periannan%3BSingh%2C+Rekha&rft.aulast=Leehey&rft.aufirst=David&rft.date=2008-04-01&rft.volume=151&rft.issue=4&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Translational+research+%3A+the+journal+of+laboratory+and+clinical+medicine&rft.issn=19315244&rft_id=info:doi/10.1016%2Fj.trsl.2008.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-20 N1 - Date created - 2008-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.trsl.2008.01.003 ER - TY - JOUR T1 - Estrogen receptors outside the nucleus in breast cancer. AN - 68091066; 17592774 AB - The estrogen receptor (ER) is the single most powerful predictor of breast cancer prognosis as well as an important contributor to the biology of carcinogenesis. In addition, endocrine therapy targeting ER directly (SERMS) or indirectly (aromatase inhibitors) forms the mainstay of adjuant therapy. Traditionally, human tumors are scored for the amount and presence of ER. However, this has centered on the population of ER found in the transformed epithelial cell nucleus. Over the last 40 years, it has been appreciated that additional cellular ER pools exist, in cytoplasm and at the plasma membrane. In this review, we discuss the important functions of extra-nuclear ER in breast cancer, including integration of function with nuclear ER. JF - Breast cancer research and treatment AU - Levin, Ellis R AU - Pietras, Richard J AD - University of California, Irvine/VA Long Beach Healthcare System, VALBHS, Long Beach, CA, USA. ellis.levin@va.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 351 EP - 361 VL - 108 IS - 3 SN - 0167-6806, 0167-6806 KW - Receptors, Estrogen KW - 0 KW - Index Medicus KW - Humans KW - Mitochondria -- metabolism KW - Female KW - Protein Transport KW - Signal Transduction -- physiology KW - Cell Nucleus -- metabolism KW - Breast Neoplasms -- metabolism KW - Receptors, Estrogen -- metabolism KW - Cell Membrane -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68091066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+and+treatment&rft.atitle=Estrogen+receptors+outside+the+nucleus+in+breast+cancer.&rft.au=Levin%2C+Ellis+R%3BPietras%2C+Richard+J&rft.aulast=Levin&rft.aufirst=Ellis&rft.date=2008-04-01&rft.volume=108&rft.issue=3&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+and+treatment&rft.issn=01676806&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-24 N1 - Date created - 2008-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predictors of Child Behavior Problems among Children of Female Vietnam Veterans AN - 61647847; 200817491 AB - This study examined the impacts of intimate partner aggression by female Vietnam veterans and their male partners on their children's behavior problems (N=100 children). Veteran and partner psychological distress were also examined as potential mediators of these relationships. Results indicated that physical and psychological aggression perpetration by both the female veteran and the male partner was associated with child behavior problems. Contrary to expectations, psychological distress in the veteran and partner was not associated with child behavior problems and did not mediate the effects of physical and psychological aggression on this outcome. Adapted from the source document. JF - Journal of Family Violence AU - Watkins, Laura E AU - Taft, Casey T AU - Hebenstreit, Claire L AU - King, Lynda A AU - King, Daniel W AD - National Center for PTSD, VA Boston Healthcare System (116B-2), 150 South Huntington Avenue, Boston, MA 02130, USA Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 135 EP - 140 PB - Springer Science+Business Media, Inc, New York, NY VL - 23 IS - 3 SN - 0885-7482, 0885-7482 KW - Veterans KW - Family Violence KW - Psychological Distress KW - Children KW - Behavior Problems KW - article KW - 2190: social problems and social welfare; victimology (rape, family violence, & child abuse) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61647847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Violence&rft.atitle=Predictors+of+Child+Behavior+Problems+among+Children+of+Female+Vietnam+Veterans&rft.au=Watkins%2C+Laura+E%3BTaft%2C+Casey+T%3BHebenstreit%2C+Claire+L%3BKing%2C+Lynda+A%3BKing%2C+Daniel+W&rft.aulast=Watkins&rft.aufirst=Laura&rft.date=2008-04-01&rft.volume=23&rft.issue=3&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Violence&rft.issn=08857482&rft_id=info:doi/10.1007%2Fs10896-007-9135-6 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-06-11 N1 - Number of references - 30 N1 - Last updated - 2016-09-28 N1 - CODEN - JFVIEV N1 - SubjectsTermNotLitGenreText - Behavior Problems; Psychological Distress; Children; Family Violence; Veterans DO - http://dx.doi.org/10.1007/s10896-007-9135-6 ER - TY - JOUR T1 - How Collaborative Is Structural Family Therapy? AN - 61415535; 200804653 AB - In response to the charge by 'collaborative' therapies, such as solution focused and narrative, that structural family therapy is an aggressive, confrontational, and impositional approach, this investigation examines the role of therapist empathy in creating a collaborative partnership in structural family therapy. Twenty-four videotaped therapy sessions were used to correlate therapists' empathic response to family members and in-session change in the family's core problem dynamic. Findings suggest that empathy is not only evident in structural family therapy, but may be an essential ingredient in establishing a collaborative relationship and facilitating within-session change. [Reprinted by permission of Sage Publications Inc., copyright 2008.] JF - The Family Journal: Counseling and Therapy for Couples and Families AU - Hammond, Ryan T AU - Nichols, Michael P AD - Central Texas Veterans Administration Hospital, Temple, Texas Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 118 EP - 124 PB - Sage Publications, Thousand Oaks CA VL - 16 IS - 2 SN - 1066-4807, 1066-4807 KW - structural family therapy KW - empathy KW - collaborative therapy KW - Therapists KW - Family Relations KW - Cooperation KW - Family Therapy KW - Empathy KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61415535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Family+Journal%3A+Counseling+and+Therapy+for+Couples+and+Families&rft.atitle=How+Collaborative+Is+Structural+Family+Therapy%3F&rft.au=Hammond%2C+Ryan+T%3BNichols%2C+Michael+P&rft.aulast=Hammond&rft.aufirst=Ryan&rft.date=2008-04-01&rft.volume=16&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=The+Family+Journal%3A+Counseling+and+Therapy+for+Couples+and+Families&rft.issn=10664807&rft_id=info:doi/10.1177%2F1066480707313773 LA - English DB - Social Services Abstracts N1 - Date revised - 2008-09-03 N1 - Number of references - 31 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Family Therapy; Cooperation; Therapists; Empathy; Family Relations DO - http://dx.doi.org/10.1177/1066480707313773 ER - TY - JOUR T1 - Treatment of obsessive-compulsive disorder in the context of an avoidant personality disorder AN - 57281048; 200908906 AB - Abstract not available. JF - Personality and Mental Health AU - Frankenburg, Frances AD - Boston University School of Medicine, USA Frances.Frankenburg@va.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 116 EP - 117 PB - Wiley-Blackwell, UK VL - 2 IS - 2 SN - 1932-8621, 1932-8621 KW - Avoidant personality disorders KW - Obsessive-Compulsive neuroses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personality+and+Mental+Health&rft.atitle=Treatment+of+obsessive-compulsive+disorder+in+the+context+of+an+avoidant+personality+disorder&rft.au=Frankenburg%2C+Frances&rft.aulast=Frankenburg&rft.aufirst=Frances&rft.date=2008-04-01&rft.volume=2&rft.issue=2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Personality+and+Mental+Health&rft.issn=19328621&rft_id=info:doi/10.1002%2Fpmh.39 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Avoidant personality disorders; Obsessive-Compulsive neuroses DO - http://dx.doi.org/10.1002/pmh.39 ER - TY - JOUR T1 - Predictors of 4-year outcome of community residential treatment for patients with substance use disorders AN - 57280565; 200909520 AB - Aims This study examined systematically how predictors of substance use disorder (SUD) treatment outcome worked together over time and identified mediators and moderators of outcome. Design The MacArthur model was applied in this naturalistic study to identify how baseline, discharge and 1-year follow-up factors worked together to predict 4-year improvement in substance-related problems. Setting Eighty-eight community residential facilities were selected based on geographic representativeness, number of patient referrals and type of treatment orientation. Participants Of 2796 male patients who completed intake assessments, 2324 were assessed at the 1-year follow-up and 2023 at the 4-year follow-up. Measurements Self-report measures of symptom severity, functioning, social resources and coping, treatment and involvement in Alcoholics Anonymous (AA) were collected at baseline and at 1- and 4-year follow-ups. Provider-rated treatment participation measures were obtained at discharge. Findings Greater substance use severity, more psychiatric symptoms, more prior arrests and stronger belief in AA-related philosophy at treatment entry predicted improvement significantly in substance-related problems 4 years later. At the 1-year follow-up, being employed and greater use of AA-related coping predicted outcome significantly. AA-related coping at 1 year mediated the relationship partially between belief in AA philosophy at treatment entry and 4-year outcome. Conclusions The findings highlight the unique and positive impact of AA involvement on long-term SUD treatment outcome and extend understanding of why AA is beneficial for patients. Submitted 12 July 2007; initial review completed 28 September 2007; final version accepted 18 December 2007. Adapted from the source document. JF - Addiction AU - Laffaye, Charlene AU - McKellar, John D AU - Ilgen, Mark A AU - Moos, Rudolf H Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 671 EP - 680 PB - Blackwell Publishing, Oxford UK VL - 103 IS - 4 SN - 0965-2140, 0965-2140 KW - Clinical outcomes KW - Severity KW - Substance abuse disorders KW - Alcoholics Anonymous KW - Coping KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57280565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Predictors+of+4-year+outcome+of+community+residential+treatment+for+patients+with+substance+use+disorders&rft.au=Laffaye%2C+Charlene%3BMcKellar%2C+John+D%3BIlgen%2C+Mark+A%3BMoos%2C+Rudolf+H&rft.aulast=Laffaye&rft.aufirst=Charlene&rft.date=2008-04-01&rft.volume=103&rft.issue=4&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2008.02147.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Coping; Substance abuse; Clinical outcomes; Substance abuse disorders; Severity; Alcoholics Anonymous DO - http://dx.doi.org/10.1111/j.1360-0443.2008.02147.x ER - TY - JOUR T1 - Preliminary evidence for gender-specific effects of topiramate as a potential aid to smoking cessation AN - 57255777; 200908131 AB - Aims Study aims were threefold: (i) to determine the feasibility, potential efficacy and safety of topiramate as an aid to smoking cessation; (ii) to examine potential predictors of abstinence including gender; and (iii) to explore topiramate's effects on tobacco withdrawal and post-cessation weight gain. Design Randomized, double-blind, placebo-controlled, 11-week clinical trial with a 6-week dosage titration period and 5 weeks of maintenance treatment. Setting Single-site, out-patient, randomized clinical trial. Participants Thirty-eight adult male and 49 female chronic smokers who smoked an average of > 10 cigarettes per day and who were motivated to try to quit smoking. Intervention Random assignment to receive either topiramate (n = 43) up to 200 mg daily in divided doses or placebo (n = 44) orally combined with brief counseling over an 11-week period. Measurements Carbon monoxide (CO)-confirmed 4-week prolonged abstinence rate during weeks 8 -11. Changes in tobacco withdrawal, body weight and safety parameters were also assessed. Findings Overall, no significant increase in the prolonged abstinence rate was detected, but logistic regression analysis indicated significant gender-specific differences. Men treated with topiramate were nearly 16 times more likely to quit smoking than women on topiramate [37.5% versus 3.7%; odds ratio (OR) = 15.6; P = 0.016] and were roughly four times more likely to quit smoking than placebo-treated men (37.5% versus 13.6%; OR = 3.8; P = 0.098). Topiramate-treated men reported significantly lower tobacco withdrawal scores than both women taking topiramate and men on placebo. On average, male cessators on placebo gained 3.30 kg, whereas topiramate led to a 0.72 kg weight loss (P = 0.03). Study discontinuation rates due to adverse events (AEs) were significantly higher in the topiramate group (topiramate 23% versus placebo 2%). The most commonly reported AEs in the topiramate arm were paraesthesia, fatigue, difficulty with concentration/attention and nervousness. Conclusions Topiramate produced gender-specific effects on smoking cessation. Male smokers had markedly greater quit rates than female smokers and men were roughly four times more likely to quit smoking when treated with topiramate as compared to placebo. Topiramate was fairly well tolerated, although higher discontinuation rates were seen. Topiramate's triple effects aiding smoking abstinence, attenuating nicotine withdrawal and preventing post-cessation weight gain might make it a promising agent for treating tobacco addiction, at least in men. Submitted 21 March 2007; initial review completed 3 July 2007; final version accepted 18 December 2007. Adapted from the source document. JF - Addiction AU - Anthenelli, Robert M AU - Blom, Thomas J AU - McElroy, Susan L AU - Keck, Paul E AD - Tri-State Tobacco and Alcohol Research Center, Cincinnati Veterans Affairs Medical Center and University of Cincinnati, OH, USA robert.anthenelli@va.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 687 EP - 694 PB - Blackwell Publishing, Oxford UK VL - 103 IS - 4 SN - 0965-2140, 0965-2140 KW - Abstinence KW - Smoking KW - Cessation KW - Topiramate KW - Gender differences KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57255777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Preliminary+evidence+for+gender-specific+effects+of+topiramate+as+a+potential+aid+to+smoking+cessation&rft.au=Anthenelli%2C+Robert+M%3BBlom%2C+Thomas+J%3BMcElroy%2C+Susan+L%3BKeck%2C+Paul+E&rft.aulast=Anthenelli&rft.aufirst=Robert&rft.date=2008-04-01&rft.volume=103&rft.issue=4&rft.spage=687&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2008.02148.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Smoking; Topiramate; Gender differences; Abstinence; Cessation DO - http://dx.doi.org/10.1111/j.1360-0443.2008.02148.x ER - TY - JOUR T1 - Opioid use disorder in the United States: Insurance status and treatment access AN - 57252856; 200820991 AB - Background. In the United States, insurance status and rates of treatment for individuals with opioid use disorder are unknown. Methods: Cross-sectional survey: 2002-2004 National Survey on Drug Use and Health (NSDUH). Bivariate and multivariate associations between demographics, treatment and insurance status and presence or absence of opioid use disorder were investigated. Results: On unadjusted analysis, young respondents, respondents of Hispanic ethnicity (OR 1.5; 95% CI 1.1-2.2), unemployed respondents (OR 2.6; 95% CI 1.8-3.8) and respondents with Medicaid (OR 4.5; 95% CI 2.5-8.3) or lack of insurance (OR 3.2; 95% CI 1.8-5.9) were more likely to have opioid use disorder. On unadjusted analysis among those with any substance use disorder, 12-16 year olds were more likely to have opioid use disorder (OR 3.4, 95% CI 2.0-5.8) than a non-opioid substance use disorder, as were women (OR for men 0.6, 95% CI 0.5-0.7) and unemployed respondents (OR 1.5, 95% CI 1.02-2.1). Only 15.2% of those with past-year opioid use disorder received treatment in the past year. Respondents treated for opioid use had higher rates of Medicaid (p <0.01), Medicare (p <0.01) and other public assistance (p = 0.01) compared with those treated for other substances. Treatments for opioid use were more likely to be hospital (p 0.04) and inpatient rehabilitation (p = 0.02) settings compared to treatment for other substance use. Among those with opioid use disorder, not being employed was independently associated with receiving treatment (AOR 3.5, 95% CI 1.4-8.5). Conclusions: In the U.S., high rates of unemployment, Medicaid and uninsurance among those with opioid use disorder and low rates of treatment suggest that efforts to expand treatment must include policy strategies to help reach a population with significant barriers to treatment access. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Becker, William C AU - Fiellin, David A AU - Merrill, Joseph O AU - Schulman, Beryl AU - Finkelstein, Ruth AU - Olsen, Yngvild AU - Busch, Susan H AD - Philadelphia Veterans Affairs Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, United States Tel: +1 215 823 5800, Fax: +1 215 823 4411 william.becker4@va.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 207 EP - 213 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 94 IS - 1-3 SN - 0376-8716, 0376-8716 KW - Opioid use disorder, Insurance, Access to care KW - Drug abusers KW - Health insurance KW - Access KW - Opioids KW - Drug abuse KW - Treatment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57252856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Opioid+use+disorder+in+the+United+States%3A+Insurance+status+and+treatment+access&rft.au=Becker%2C+William+C%3BFiellin%2C+David+A%3BMerrill%2C+Joseph+O%3BSchulman%2C+Beryl%3BFinkelstein%2C+Ruth%3BOlsen%2C+Yngvild%3BBusch%2C+Susan+H&rft.aulast=Becker&rft.aufirst=William&rft.date=2008-04-01&rft.volume=94&rft.issue=1-3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.11.018 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Opioids; Drug abuse; Drug abusers; Health insurance; Access; Treatment DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.11.018 ER - TY - JOUR T1 - Social Networks and Incident Stroke Among Women With Suspected Myocardial Ischemia AN - 21183912; 11273750 AB - Objective: To describe the prospective relationship between social networks and nonfatal stroke events in a sample of women with suspected myocardial ischemia. Social networks are an independent predictor of all-cause and cardiovascular mortality, but their relationship with stroke events in at-risk populations is largely unknown. Method: A total of 629 women (mean age = 59.6 plus or minus 11.6 years) were evaluated at baseline for cardiovascular disease risk factors as part of a protocol including coronary angiography; the subjects were followed over a median 5.9 years to track the incidence of cardiovascular events including stroke. Participants also completed the Social Network Index (SNI), measuring the presence/absence of 12 types of common social relationships. Results: Stroke events occurred among 5.1% of the sample over follow-up. More isolated women were older and less educated, with higher rates of smoking and hypertension, and increased use of cardiovascular medications. Women with smaller social networks were also more likely to show elevations (scores of greater than or equal to 10) on the Beck Depression Inventory (54% versus 41%, respectively; p = .003). Relative to women with higher SNI scores, Cox regression results indicated that more isolated women experienced strokes at greater than twice the rate of those with more social relationships after adjusting for covariates (hazard ratio = 2.7; 95% Confidence Interval = 1.1-6.7). Conclusions: Smaller social networks are a robust predictor of stroke in at-risk women, and the magnitude of the association rivals that of conventional risk factors. JF - Psychosomatic Medicine AU - Rutledge, T AU - Linke, SE AU - Olson, M B AU - Francis, J AU - Johnson, B D AU - Bittner, V AU - York, K AU - McClure, C AU - Kelsey, S F AU - Reis, SE AU - Cornell, CE AU - Vaccarino, V AU - Sheps, D S AU - Shaw, L J AD - Psychology Service 116B, VA San Diego Healthcare System, Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161, USA, Thomas.Rutledge@va.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 282 EP - 287 VL - 70 IS - 3 SN - 0033-3174, 0033-3174 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Myocardial ischemia KW - Age KW - stroke KW - Smoking KW - Risk factors KW - Drugs KW - Mortality KW - Inventories KW - Depression KW - Stroke KW - depression KW - Social interactions KW - Angiography KW - hypertension KW - Females KW - Cardiovascular diseases KW - Hypertension KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21183912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+Medicine&rft.atitle=Social+Networks+and+Incident+Stroke+Among+Women+With+Suspected+Myocardial+Ischemia&rft.au=Rutledge%2C+T%3BLinke%2C+SE%3BOlson%2C+M+B%3BFrancis%2C+J%3BJohnson%2C+B+D%3BBittner%2C+V%3BYork%2C+K%3BMcClure%2C+C%3BKelsey%2C+S+F%3BReis%2C+SE%3BCornell%2C+CE%3BVaccarino%2C+V%3BSheps%2C+D+S%3BShaw%2C+L+J&rft.aulast=Rutledge&rft.aufirst=T&rft.date=2008-04-01&rft.volume=70&rft.issue=3&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+Medicine&rft.issn=00333174&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Smoking; Inventories; Mortality; Age; Angiography; Myocardial ischemia; Depression; Risk factors; Stroke; Cardiovascular diseases; Hypertension; Social interactions; stroke; hypertension; Females; depression; Drugs ER - TY - JOUR T1 - Rehospitalization After Hip Fracture: Predictors and Prognosis from a National Veterans Study AN - 20709922; 8225071 AB - OBJECTIVESTo estimate the risk and long-term prognostic significance of 30-day readmission postdischarge of a 4-year cohort of elderly veterans first admitted to Medicare hospitals for treatment of hip fractures (HFx), controlling for comorbidities. DESIGNRetrospective, national secondary data analysis. SETTINGNational Medicare and Veterans Health Administration (VHA) facilities. PARTICIPANTSThe study cohort was 41,331 veterans with a HFx first admitted to a Medicare eligible facility during 1999 to 2002. MEASUREMENTSHFxs were linked with all other Medicare and VHA inpatient discharge files to capture dual inpatient use. Logistic regression was used to examine the relationship between 30-day readmission and age, sex, inpatient length of stay, and selected Elixhauser comorbidities. RESULTSApproximately 18.3% (7,579-41,331) of HFx patients were readmitted within 30 days. Of those with 30-day readmissions, 48.5% (3,675-7,579) died within 1 year, compared with 24.9% (8,388-33,752) of those without 30-day readmissions. Readmission risk was significantly greater in the presence of specific comorbidities, ranging from 11% greater risk for patients with fluid and electrolyte disorders (95% confidence interval (CI)=1.04-1.20) to 43% for renal failure (95% CI=1.29-1.60). For this cohort, cardiac arrhythmias (24%), chronic pulmonary disease (28%), and congestive heart failure (16%) were common comorbidities, and all affected the risk of 30-day readmission. CONCLUSIONPatients with HFx with 30-day readmissions were nearly twice as likely to die within 1 year. Identification of several predictive comorbidities at discharge and examination of reasons for subsequent readmission suggests that readmission was largely due to active comorbid clinical problems. These comorbidity findings have implications for the current Centers for Medicare and Medicaid Services (CMS) pay-for-performance initiatives, especially those related to better coordination of care for patients with chronic illnesses. These comorbidity findings for elderly patients with HFx may also provide data to enable CMS and healthcare providers to more accurately differentiate between comorbidities and hospital-acquired complications under the current CMS initiative related to nonpayment for certain types of medical conditions and hospital acquired infections. JF - Journal of the American Geriatrics Society AU - French, Dustin D AU - Bass, Elizabeth AU - Bradham, Douglas D AU - Campbell, Robert R AU - Rubenstein, Laurence Z AD - Veterans Integrated Service Network-8 Patient Safety Center of Inquiry, James A. Haley Veterans Affairs Medical Center, Tampa, Florida, Dustin.French@va.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 705 EP - 710 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 56 IS - 4 KW - Risk Abstracts KW - Age KW - electrolytes KW - Morbidity KW - hip fracture KW - infection KW - elderly KW - Hospitals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20709922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Rehospitalization+After+Hip+Fracture%3A+Predictors+and+Prognosis+from+a+National+Veterans+Study&rft.au=French%2C+Dustin+D%3BBass%2C+Elizabeth%3BBradham%2C+Douglas+D%3BCampbell%2C+Robert+R%3BRubenstein%2C+Laurence+Z&rft.aulast=French&rft.aufirst=Dustin&rft.date=2008-04-01&rft.volume=56&rft.issue=4&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=1532-5415&rft_id=info:doi/10.1111%2Fj.1532-5415.2007.01479.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Morbidity; elderly; hip fracture; Hospitals; infection; electrolytes; Age DO - http://dx.doi.org/10.1111/j.1532-5415.2007.01479.x ER - TY - JOUR T1 - Getting Beyond "Don't Ask; Don't Tell": an Evaluation of US Veterans Administration Postdeployment Mental Health Screening of Veterans Returning From Iraq and Afghanistan AN - 20649714; 8083826 AB - OBJECTIVES: We sought to evaluate outcomes of the Veterans Administration (VA) Afghan and Iraq Post-Deployment Screen for mental health symptoms. METHODS: Veterans Administration clinicians were encouraged to refer Iraq or Afghanistan veterans who screened positive for posttraumatic stress disorder, depression, or high-risk alcohol use to a VA mental health clinic. Multivariate methods were used to determine predictors of screening, the proportions who screened positive for particular mental health problems, and predictors of VA mental health clinic attendance. RESULTS: Among 750 Iraq and Afghanistan veterans who were referred to a VA medical center and 5 associated community clinics, 338 underwent postdeployment screening; 233 (69%) screened positive for mental health problems. Having been seen in primary care (adjusted odd ratio [AOR]=13.3; 95% confidence interval [CI]=8.31, 21.3) and at a VA community clinic (AOR=3.28; 95% CI=2.03, 5.28) predicted screening. African American veterans were less likely to have been screened than were White veterans (AOR=0.45; 95% CI=0.22, 0.91). Of 233 veterans who screened positive, 170 (73%) completed a mental health follow-up visit. CONCLUSIONS: A substantial proportion of veterans met screening criteria for co-occurring mental health problems, suggesting that the VA screens may help overcome a "don't ask, don't tell" climate that surrounds stigmatized mental illness. Based on data from 1 VA facility, VA postdeployment screening increases mental health clinic attendance among Iraq and Afghanistan veterans. JF - American Journal of Public Health AU - Seal, Karen H AU - Bertenthal, Daniel AU - Maguen, Shira AU - Gima, Kristian AU - Chu, Ann AU - Marmar, Charles R AD - Karen H. Seal, Charles R. Marmar, and Shira Maguen are with the San Francisco Veterans Administration Medical Center and the University of California, San Francisco, and are affiliated with the San Francisco Veterans Administration Health Services Research and Development Research Enhancement Award Program. Daniel Bertenthal, Kristian Gima, and Ann Chu are with the San Francisco Veterans Administration Medical Center Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 714 EP - 720 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 98 IS - 4 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts KW - Alcohol KW - USA KW - Psychology KW - Africa KW - Afghanistan KW - mental disorders KW - depression KW - Iraq KW - Ethnic groups KW - Public health KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20649714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Getting+Beyond+%22Don%27t+Ask%3B+Don%27t+Tell%22%3A+an+Evaluation+of+US+Veterans+Administration+Postdeployment+Mental+Health+Screening+of+Veterans+Returning+From+Iraq+and+Afghanistan&rft.au=Seal%2C+Karen+H%3BBertenthal%2C+Daniel%3BMaguen%2C+Shira%3BGima%2C+Kristian%3BChu%2C+Ann%3BMarmar%2C+Charles+R&rft.aulast=Seal&rft.aufirst=Karen&rft.date=2008-04-01&rft.volume=98&rft.issue=4&rft.spage=714&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Alcohol; Psychology; depression; mental disorders; Ethnic groups; Public health; USA; Africa; Afghanistan; Iraq ER - TY - JOUR T1 - Penicillin G-Resistant Viridans Group Streptococcal Endocarditis and Interpretation of the American Heart Association's Guidelines for the Treatment of Infective Endocarditis AN - 19476324; 8372675 AB - We report a case of endocarditis due to a penlcillin-"resistant" Streptococcus parasanguinis, discuss interpretations of the American Heart Association's guidelines for the treatment of viridans group streptococcal infection, and comment on therapy for infective endocarditis due to penicillin-resistant viridans group streptococci. JF - Clinical Infectious Diseases AU - Fujitani, S AU - Rowlinson, M-C AU - George, W L AD - VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA, William.george@med.va.gov Y1 - 2008/04/01/ PY - 2008 DA - 2008 Apr 01 SP - 1064 EP - 1066 VL - 46 IS - 7 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Heart KW - Case reports KW - Streptococcus parasanguinis KW - Infection KW - Penicillin KW - Endocarditis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19476324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Penicillin+G-Resistant+Viridans+Group+Streptococcal+Endocarditis+and+Interpretation+of+the+American+Heart+Association%27s+Guidelines+for+the+Treatment+of+Infective+Endocarditis&rft.au=Fujitani%2C+S%3BRowlinson%2C+M-C%3BGeorge%2C+W+L&rft.aulast=Fujitani&rft.aufirst=S&rft.date=2008-04-01&rft.volume=46&rft.issue=7&rft.spage=1064&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Heart; Case reports; Infection; Penicillin; Endocarditis; Streptococcus; Streptococcus parasanguinis ER - TY - JOUR T1 - Systematic review: comparative effectiveness and harms of treatments for clinically localized prostate cancer. AN - 70404299; 18252677 AB - The comparative effectiveness of localized prostate cancer treatments is largely unknown. To compare the effectiveness and harms of treatments for localized prostate cancer. MEDLINE (through September 2007), the Cochrane Library (through Issue 3, 2007), and the Cochrane Review Group in Prostate Diseases and Urologic Malignancies registry (through November 2007). Randomized, controlled trials (RCTs) published in any language and observational studies published in English that evaluated treatments and reported clinical or biochemical outcomes in localized prostate cancer. 2 researchers extracted information on study design, sample characteristics, interventions, and outcomes. 18 RCTs and 473 observational studies met inclusion criteria. One [one randomized controlled trial] [corrected] RCT enrolled mostly men without prostate-specific antigen (PSA)-detected disease and reported that, compared with watchful waiting, radical prostatectomy reduced crude [corrected] all-cause mortality (24% vs. 30%; P = 0.04) and prostate cancer-specific mortality (10% [corrected] vs. 15% [corrected]; P = 0.01) at 10 years [corrected] Effectiveness was limited to men younger than age 65 years but was not associated with Gleason score or baseline PSA level. An older, smaller trial found no significant overall survival differences between radical prostatectomy and watchful waiting (risk difference, 0% [95% CI, -19% to 18%]). Radical prostatectomy reduced disease recurrence at 5 years compared with external-beam radiation therapy in 1 small, older trial (14% vs. 39%; risk difference, 21%; P = 0.04). No external-beam radiation regimen was superior to another in reducing mortality. No randomized trials evaluated primary androgen deprivation. Androgen deprivation used adjuvant to radical prostatectomy did not improve biochemical progression compared with radical prostatectomy alone (risk difference, 0% [CI, -7% to 7%]). No randomized trial evaluated brachytherapy, cryotherapy, robotic radical prostatectomy, or photon-beam or intensity-modulated radiation therapy. Observational studies showed wide and overlapping effectiveness estimates within and between treatments. Adverse event definitions and severity varied widely. The Prostate Cancer Outcomes Study reported that urinary leakage (> or =1 event/d) was more common with radical prostatectomy (35%) than with radiation therapy (12%) or androgen deprivation (11%). Bowel urgency occurred more often with radiation (3%) or androgen deprivation (3%) than with radical prostatectomy (1%). Erectile dysfunction occurred frequently after all treatments (radical prostatectomy, 58%; radiation therapy, 43%; androgen deprivation, 86%). A higher risk score incorporating histologic grade, PSA level, and tumor stage was associated with increased risk for disease progression or recurrence regardless of treatment. Only 3 randomized trials compared effectiveness between primary treatments. No trial enrolled patients with prostate cancer primarily detected with PSA testing. Assessment of the comparative effectiveness and harms of localized prostate cancer treatments is difficult because of limitations in the evidence. JF - Annals of internal medicine AU - Wilt, Timothy J AU - MacDonald, Roderick AU - Rutks, Indulis AU - Shamliyan, Tatyana A AU - Taylor, Brent C AU - Kane, Robert L AD - University of Minnesota School of Medicine, Minneapolis Veterans Affairs Center for Chronic Disease Outcomes Research, Minneapolis, Minnesota 55417, USA. tim.wilt@med.va.gov Y1 - 2008/03/18/ PY - 2008 DA - 2008 Mar 18 SP - 435 EP - 448 VL - 148 IS - 6 KW - Androgen Antagonists KW - 0 KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Abridged Index Medicus KW - Index Medicus KW - Androgen Antagonists -- adverse effects KW - Prostatectomy -- adverse effects KW - Humans KW - Brachytherapy -- adverse effects KW - Prostate-Specific Antigen -- blood KW - Neoadjuvant Therapy KW - Neoplasm Recurrence, Local -- diagnosis KW - Disease Progression KW - Male KW - Cause of Death KW - Radiotherapy -- adverse effects KW - Prostatic Neoplasms -- mortality KW - Prostatic Neoplasms -- diagnosis KW - Prostatic Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70404299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Systematic+review%3A+comparative+effectiveness+and+harms+of+treatments+for+clinically+localized+prostate+cancer.&rft.au=Wilt%2C+Timothy+J%3BMacDonald%2C+Roderick%3BRutks%2C+Indulis%3BShamliyan%2C+Tatyana+A%3BTaylor%2C+Brent+C%3BKane%2C+Robert+L&rft.aulast=Wilt&rft.aufirst=Timothy&rft.date=2008-03-18&rft.volume=148&rft.issue=6&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-03-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Evid Based Med. 2008 Oct;13(5):139 [18836107] Erratum In: Ann Intern Med. 2008 Jun 3;148(11):888 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Controversies in NICE Guidance on Prostate Cancer: Commentary AN - 57250692; 200820792 AB - The NICE guidelines on prostate cancer provide comprehensive advice on best practice for diagnosis and treatment of prostate cancer. They are based on systematic reviews of the evidence, incorporate multidisciplinary opinions, and try to balance the values of healthcare providers and patients for various outcomes while emphasising a patient centred approach. Their conclusions are generally consistent with other reviews and guidelines evaluating similar evidence. If followed, these recommendations will likely improve prostate cancer outcomes while reducing unnecessary, ineffective, harmful, and costly care. References. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Wilt, Timothy J AD - Minneapolis VA Center for Chronic Disease Outcomes Research, Minneapolis, MN, US Tim.wilt@med.va.gov Y1 - 2008/03/15/ PY - 2008 DA - 2008 Mar 15 SP - 612 EP - 614 PB - British Medical Association, BMJ Publishing Group, London UK VL - 336 IS - 7644 SN - 0959-535X, 0959-535X KW - Diagnosis KW - Guidelines KW - Treatment KW - Prostatic cancer KW - National institutions KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57250692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Controversies+in+NICE+Guidance+on+Prostate+Cancer%3A+Commentary&rft.au=Wilt%2C+Timothy+J&rft.aulast=Wilt&rft.aufirst=Timothy&rft.date=2008-03-15&rft.volume=336&rft.issue=7644&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.39501.621690.AD LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Prostatic cancer; Diagnosis; Treatment; Guidelines; National institutions DO - http://dx.doi.org/10.1136/bmj.39501.621690.AD ER - TY - CPAPER T1 - Surprises in Cross Calibration: A Comparison of Body Composition Values between DXA Manufacturers. T2 - 14th Annual Meeting of the International Society for Clinical Densitometry AN - 40904370; 4842664 JF - 14th Annual Meeting of the International Society for Clinical Densitometry AU - Williams, Sparkle Joy Y1 - 2008/03/12/ PY - 2008 DA - 2008 Mar 12 KW - Dual energy X-ray absorptiometry KW - Body composition KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40904370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+International+Society+for+Clinical+Densitometry&rft.atitle=Surprises+in+Cross+Calibration%3A+A+Comparison+of+Body+Composition+Values+between+DXA+Manufacturers.&rft.au=Williams%2C+Sparkle+Joy&rft.aulast=Williams&rft.aufirst=Sparkle&rft.date=2008-03-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+International+Society+for+Clinical+Densitometry&rft.issn=&rft_id=info:doi/ L2 - http://www.iscd.org/Visitors/pdfs/ISCD_abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - No Significant Difference in the Semi-quantitative Analysis of Diphosphonate Uptake in the Jaw in Subjects Receiving Bisphosphonates. T2 - 14th Annual Meeting of the International Society for Clinical Densitometry AN - 40903870; 4842654 JF - 14th Annual Meeting of the International Society for Clinical Densitometry AU - Uysal, Askin AU - Boktor, Moheb AU - Ghanta, Deepa AU - Ramachanran, Anil AU - Yaturu, Subhashini Y1 - 2008/03/12/ PY - 2008 DA - 2008 Mar 12 KW - Bisphosphonates KW - Jaw KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40903870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+International+Society+for+Clinical+Densitometry&rft.atitle=No+Significant+Difference+in+the+Semi-quantitative+Analysis+of+Diphosphonate+Uptake+in+the+Jaw+in+Subjects+Receiving+Bisphosphonates.&rft.au=Uysal%2C+Askin%3BBoktor%2C+Moheb%3BGhanta%2C+Deepa%3BRamachanran%2C+Anil%3BYaturu%2C+Subhashini&rft.aulast=Uysal&rft.aufirst=Askin&rft.date=2008-03-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+International+Society+for+Clinical+Densitometry&rft.issn=&rft_id=info:doi/ L2 - http://www.iscd.org/Visitors/pdfs/ISCD_abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Relationship between PTSD Symptoms and Anxiety Sensitivity in OEF/OIF and Persian Gulf Veterans T2 - 28th Annual Conference of the Anxiety Disorders Association of America AN - 40800343; 4795525 JF - 28th Annual Conference of the Anxiety Disorders Association of America AU - Crowe, Chris M AU - Dodd, Jonathan AU - Price, Matthew Y1 - 2008/03/06/ PY - 2008 DA - 2008 Mar 06 KW - Arabian Sea, Persian Gulf KW - Post-traumatic stress disorder KW - Anxiety KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40800343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=28th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America&rft.atitle=The+Relationship+between+PTSD+Symptoms+and+Anxiety+Sensitivity+in+OEF%2FOIF+and+Persian+Gulf+Veterans&rft.au=Crowe%2C+Chris+M%3BDodd%2C+Jonathan%3BPrice%2C+Matthew&rft.aulast=Crowe&rft.aufirst=Chris&rft.date=2008-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=28th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B81BE0F57-4D94-4A80-BFDF -9004255ECDAF%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Preoperative Psychosocial Evaluation of Penile Prosthesis Candidates AN - 745606471; 12505796 AB - Penile prosthesis surgery is a recommended treatment option for a subset of patients who present with erectile dysfunction (ED). Although treatment outcome research indicates that patients are generally satisfied with this intervention, it remains an invasive procedure with risk for complications. A review of the literature reveals general agreement for the importance of a thorough preoperative evaluation to determine appropriateness for a penile implant; however, there are no known descriptions of such an evaluation in the literature. This article provides an introduction to the domains that are most relevant to assess in a patient who is considering penile implant surgery: sexual history (including organic and psychogenic causes of ED), success and utilization of other treatment interventions, relationship functioning, and patient expectations for and knowledge of the procedure. The advantages to this approach are presented, particularly in enhancing patient satisfaction with treatment outcomes. JF - American Journal of Men's Health AU - Ulloa, Erin Winters AU - Silberbogen, Amy K AU - Brown, Kirstin AD - VA Boston Healthcare System, Boston University School of Medicine, erin.ulloa2@va.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 68 EP - 75 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 2 IS - 1 SN - 1557-9883, 1557-9883 KW - Risk Abstracts KW - Historical account KW - erectile dysfunction KW - surgery KW - complications KW - intervention KW - Reviews KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745606471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Men%27s+Health&rft.atitle=Preoperative+Psychosocial+Evaluation+of+Penile+Prosthesis+Candidates&rft.au=Ulloa%2C+Erin+Winters%3BSilberbogen%2C+Amy+K%3BBrown%2C+Kirstin&rft.aulast=Ulloa&rft.aufirst=Erin&rft.date=2008-03-01&rft.volume=2&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Men%27s+Health&rft.issn=15579883&rft_id=info:doi/10.1177%2F1557988307313439 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Historical account; complications; erectile dysfunction; Reviews; intervention; surgery DO - http://dx.doi.org/10.1177/1557988307313439 ER - TY - JOUR T1 - Review: hepatotoxicity and EGFR inhibition. AN - 70481097; 18391919 JF - Clinical advances in hematology & oncology : H&O AU - Ramanarayanan, Jeyanthi AU - Krishnan, Ganapathy S AD - Stratton VA Medical Center, Albany, NY 12208, USA. Jeyanthi.ramanarayanan@va.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 200 EP - 201 VL - 6 IS - 3 SN - 1543-0790, 1543-0790 KW - Protein Kinase Inhibitors KW - 0 KW - Quinazolines KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Erlotinib Hydrochloride KW - DA87705X9K KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Chemical and Drug Induced Liver Injury -- etiology KW - Humans KW - Cytochrome P-450 Enzyme System -- drug effects KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Protein Kinase Inhibitors -- adverse effects KW - Cytochrome P-450 CYP3A -- metabolism KW - Quinazolines -- adverse effects KW - Pancreatic Neoplasms -- drug therapy KW - Cytochrome P-450 CYP3A -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70481097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+advances+in+hematology+%26+oncology+%3A+H%26O&rft.atitle=Review%3A+hepatotoxicity+and+EGFR+inhibition.&rft.au=Ramanarayanan%2C+Jeyanthi%3BKrishnan%2C+Ganapathy+S&rft.aulast=Ramanarayanan&rft.aufirst=Jeyanthi&rft.date=2008-03-01&rft.volume=6&rft.issue=3&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=Clinical+advances+in+hematology+%26+oncology+%3A+H%26O&rft.issn=15430790&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-24 N1 - Date created - 2008-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Successful implementation of ceiling-mounted lift systems. AN - 70388338; 18330384 AB - Rehabilitation nurses are well aware of the risks for musculoskeletal injuries related to patient handling tasks. Repetitive lifting, turning, and repositioning of patients with mobility limitations can take a toll on the nurse. This article chronicles integration of ceiling lift technology for patient-handling tasks into nursing practice on a spinal cord injury inpatient unit. JF - Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses AU - Weinel, Diana AD - James A. Haley Veterans' Hospital, USA. diana.weinel@va.gov PY - 2008 SP - 63 EP - 6, 87 VL - 33 IS - 2 SN - 0278-4807, 0278-4807 KW - Nursing KW - Equipment Design KW - Humans KW - Rehabilitation Nursing KW - Health Plan Implementation KW - Musculoskeletal Diseases -- prevention & control KW - Spinal Cord Injuries -- rehabilitation KW - Occupational Diseases -- prevention & control KW - Lifting KW - Spinal Cord Injuries -- nursing KW - Protective Devices UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70388338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rehabilitation+nursing+%3A+the+official+journal+of+the+Association+of+Rehabilitation+Nurses&rft.atitle=Successful+implementation+of+ceiling-mounted+lift+systems.&rft.au=Weinel%2C+Diana&rft.aulast=Weinel&rft.aufirst=Diana&rft.date=2008-03-01&rft.volume=33&rft.issue=2&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Rehabilitation+nursing+%3A+the+official+journal+of+the+Association+of+Rehabilitation+Nurses&rft.issn=02784807&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-29 N1 - Date created - 2008-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux disease. AN - 70373998; 18206149 AB - Most patients with gastroesophageal reflux disease (GERD) report that stress exacerbates their symptoms, yet mechanisms underlying this association remain unknown. We sought to determine the effect of an acute laboratory stressor on perceptual and emotional responses to intraesophageal acid perfusion in healthy controls and patients with GERD. Forty-six patients with heartburn and 10 healthy controls underwent upper endoscopy and, if negative, pH monitoring. Assessment of psychologic factors and health-related quality of life was done by a questionnaire. Perceptual and emotional responses to intraesophageal acid at baseline, during auditory stress, and during an auditory control condition were determined using a randomized crossover design. Plasma levels of norepinephrine, adrenocorticotropic hormone, and cortisol were assessed. Twenty-nine subjects were identified as nonerosive reflux disease and 17 as erosive esophagitis. Quality of life, psychologic profile, and personality assessment variables were similar among the 2 patient groups and the controls. There was a significant reduction in mean lag time to initial symptom perception and an increase in mean intensity rating and mean acid perfusion sensitivity score in the 2 patient groups during the stress period, which was not seen during the control condition. Healthy controls demonstrated lack of a significant change in all parameters of stimulus response functions to acid, regardless of condition. Acute auditory stress can exacerbate heartburn symptoms in GERD patients by enhancing perceptual response to intraesophageal acid exposure. This greater perceptual response is associated with greater emotional responses to the stressor. JF - Gastroenterology AU - Fass, Ronnie AU - Naliboff, Bruce D AU - Fass, Shira S AU - Peleg, Nitzan AU - Wendel, Christopher AU - Malagon, Isaac B AU - Mayer, Emeran A AD - The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, Arizona, USA. Ronnie.Fass@va.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 696 EP - 705 VL - 134 IS - 3 KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Hydrocortisone KW - WI4X0X7BPJ KW - Norepinephrine KW - X4W3ENH1CV KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Humans KW - Norepinephrine -- blood KW - Hydrocortisone -- blood KW - Adult KW - Esophageal pH Monitoring KW - Surveys and Questionnaires KW - Cross-Over Studies KW - Middle Aged KW - Endoscopy, Digestive System KW - Time Factors KW - Female KW - Male KW - Adrenocorticotropic Hormone -- blood KW - Emotions KW - Stress, Psychological -- metabolism KW - Perception KW - Gastroesophageal Reflux -- pathology KW - Gastroesophageal Reflux -- metabolism KW - Stress, Psychological -- pathology KW - Quality of Life KW - Noise -- adverse effects KW - Stress, Psychological -- complications KW - Gastroesophageal Reflux -- psychology KW - Gastric Acid -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70373998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=The+effect+of+auditory+stress+on+perception+of+intraesophageal+acid+in+patients+with+gastroesophageal+reflux+disease.&rft.au=Fass%2C+Ronnie%3BNaliboff%2C+Bruce+D%3BFass%2C+Shira+S%3BPeleg%2C+Nitzan%3BWendel%2C+Christopher%3BMalagon%2C+Isaac+B%3BMayer%2C+Emeran+A&rft.aulast=Fass&rft.aufirst=Ronnie&rft.date=2008-03-01&rft.volume=134&rft.issue=3&rft.spage=696&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=1528-0012&rft_id=info:doi/10.1053%2Fj.gastro.2007.12.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-20 N1 - Date created - 2008-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1053/j.gastro.2007.12.010 ER - TY - JOUR T1 - Substance abuse-related mortality among middle-aged male VA psychiatric patients. AN - 70348360; 18308910 AB - This study evaluated mortality and causes of death over a seven-year period among middle-aged male psychiatric patients with and without co-occurring substance use disorder. This cohort study examined mortality among 169,051 male Vietnam-era veterans ages 40 to 59 treated for psychiatric disorders by the U.S. Department of Veterans Affairs (VA) between April and September 1998. Demographic variables, diagnoses, and prior hospitalizations were obtained from VA electronic medical records. Mortality status was obtained from VA benefits records. Cause-of-death data were purchased from the National Death Index for a random sample of 3,383 decedents. Mortality among psychiatric patients with and without diagnosed co-occurring substance use disorders was compared by logistic regression, with controls for demographic factors, psychiatric and medical diagnoses, and prior hospitalizations. Causes of death for psychiatric patients with and without co-occurring disorders were compared by chi square analyses. Results were compared to age- and race-matched norms for the U.S. population. The risk-adjusted probability of dying was 55% higher among psychiatric patients with co-occurring substance use disorders than among those without substance use disorders (OR=1.58-1.69). Overdoses and substance abuse-linked illnesses accounted for 27.6% of deaths among psychiatric patients with co-occurring substance use disorders, compared with only 8.8% of deaths among other psychiatric patients. Substance use disorders strongly contributed to premature death among male psychiatric patients. Secondary prevention is needed to reduce substance misuse and improve medical care for substance-related illnesses among psychiatric patients with co-occurring substance use disorders. JF - Psychiatric services (Washington, D.C.) AU - Rosen, Craig S AU - Kuhn, Eric AU - Greenbaum, Mark A AU - Drescher, Kent D AD - National Center for Posttraumatic Stress Disorder, Department of Veterans Affairs, Palo Alto Health Care System, Menlo Park, CA 94025, USA. craig.rosen@va.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 290 EP - 296 VL - 59 IS - 3 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - International Classification of Diseases KW - Humans KW - Schizophrenic Psychology KW - Middle Aged KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Cause of Death KW - Veterans -- statistics & numerical data KW - Veterans -- psychology KW - Substance-Related Disorders -- mortality KW - Schizophrenia -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70348360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Substance+abuse-related+mortality+among+middle-aged+male+VA+psychiatric+patients.&rft.au=Rosen%2C+Craig+S%3BKuhn%2C+Eric%3BGreenbaum%2C+Mark+A%3BDrescher%2C+Kent+D&rft.aulast=Rosen&rft.aufirst=Craig&rft.date=2008-03-01&rft.volume=59&rft.issue=3&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/10.1176%2Fappi.ps.59.3.290 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-25 N1 - Date created - 2008-02-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1176/appi.ps.59.3.290 ER - TY - JOUR T1 - Prescription medication misuse and substance use disorder in VA primary care patients with chronic pain. AN - 70320285; 18291290 AB - The goal of this paper was to examine the relationship between history of substance use disorder (SUD) and self-reported prescription medication misuse in 127 primary care patients who receive opioid medications for treatment of chronic pain. Participants completed measures of pain location, pain intensity, disability due to pain, and misuse of prescription medications. Other measures included demographic characteristics, psychiatric symptomatology and quality of life. Seventy-eight percent of participants reported at least one indicator of medication misuse in the prior year. After adjusting for age and clinical factors (pain severity, depression severity, current alcohol or substance use disorder), participants with SUD history were significantly more likely than participants without SUD history to report borrowing pain medications from others (OR=6.62, 95% CI=1.4-30.7) and requesting an early refill of pain medication (OR=3.86, 95% CI=1.5-9.6). Misuse of prescription medications is a concern among primary care patients with chronic pain. Participants with a lifetime history of SUD are more likely to endorse some aberrant medication-related behaviors. Patients with SUD histories should be carefully evaluated for medication misuse potential and may require more intense assessment and follow-up. JF - General hospital psychiatry AU - Morasco, Benjamin J AU - Dobscha, Steven K AD - Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, Department of Psychiatry, Oregon Health and Science University, Portland, OR 97219, USA. benjamin.morasco@va.gov PY - 2008 SP - 93 EP - 99 VL - 30 IS - 2 SN - 0163-8343, 0163-8343 KW - Analgesics, Opioid KW - 0 KW - Pharmaceutical Preparations KW - Index Medicus KW - Humans KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Chronic Disease KW - Oregon -- epidemiology KW - Male KW - Female KW - Pain -- drug therapy KW - Primary Health Care KW - Analgesics, Opioid -- adverse effects KW - Analgesics, Opioid -- administration & dosage KW - Drug Prescriptions KW - Substance-Related Disorders -- epidemiology KW - Hospitals, Veterans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70320285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=General+hospital+psychiatry&rft.atitle=Prescription+medication+misuse+and+substance+use+disorder+in+VA+primary+care+patients+with+chronic+pain.&rft.au=Morasco%2C+Benjamin+J%3BDobscha%2C+Steven+K&rft.aulast=Morasco&rft.aufirst=Benjamin&rft.date=2008-03-01&rft.volume=30&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=General+hospital+psychiatry&rft.issn=01638343&rft_id=info:doi/10.1016%2Fj.genhosppsych.2007.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-02 N1 - Date created - 2008-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.genhosppsych.2007.12.004 ER - TY - JOUR T1 - Hepatitis C testing and infection rates in bipolar patients with and without comorbid substance use disorders. AN - 70289871; 18271905 AB - To determine and compare hepatitis C (HCV) screening and testing rates among four groups: those with (i) bipolar disorder [BD group (history of BD but no substance use disorder)]; (ii) substance use disorders [SUD group (history of SUD but no BD)]; (iii) co-occurring disorders [DD group (history of both BD and an SUD)]; and (iv) a control group (no history of either bipolar disorder or substance use disorder). Our hypothesis was that HCV antibody testing rates and HCV prevalence would be higher in the BD, SUD, and DD groups than the control group. Data were retrospectively collected on 325,410 patients seen between 1998 and 2004 within facilities and clinics of the Veterans Integrated Service Network (VISN) 20 Northwest Veterans Health Care Administration from electronic medical records. HCV screening and prevalence rates were compared between the BD, SUD, DD, and control groups. Odds ratios and relative risks were determined and compared between groups. Patients in the BD, SUD, and DD groups had been tested at a higher rate than controls and were at increased risk for HCV infection compared with controls. These high-risk groups had a 1.31-fold, 4.86-fold, and 5.46-fold increase in the relative risk of HCV infection, respectively. Overall, compared to the control group, the relative risk of a patient having HCV if he or she had BD (with or without an SUD) was 3.6. Patients with BD and comorbid SUD had an over fourfold increase in relative risk for HCV than our control group and a similar risk as patients in our SUD group. Furthermore, even if bipolar patients did not have a comorbid SUD (the BD group), their relative risk of HCV was significantly higher than that of the control group. This suggests that patients with BD, particularly those with a comorbid SUD, should be screened and tested for HCV. JF - Bipolar disorders AU - Matthews, Annette M AU - Huckans, Marilyn S AU - Blackwell, Aaron D AU - Hauser, Peter AD - Northwest Hepatitis C Resource Center, and Behaviorual Health and Clinical Neurosciences Division, Portland VA Medical Center, Portland, OR 97202, USA. annette.matthew@med.va.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 266 EP - 270 VL - 10 IS - 2 SN - 1398-5647, 1398-5647 KW - Index Medicus KW - Severity of Illness Index KW - Polymerase Chain Reaction KW - Humans KW - Adult KW - Male KW - Female KW - Diagnostic and Statistical Manual of Mental Disorders KW - Comorbidity KW - Prevalence KW - Bipolar Disorder -- diagnosis KW - Bipolar Disorder -- epidemiology KW - Hepatitis C -- blood KW - Hepatitis C -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70289871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bipolar+disorders&rft.atitle=Hepatitis+C+testing+and+infection+rates+in+bipolar+patients+with+and+without+comorbid+substance+use+disorders.&rft.au=Matthews%2C+Annette+M%3BHuckans%2C+Marilyn+S%3BBlackwell%2C+Aaron+D%3BHauser%2C+Peter&rft.aulast=Matthews&rft.aufirst=Annette&rft.date=2008-03-01&rft.volume=10&rft.issue=2&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Bipolar+disorders&rft.issn=13985647&rft_id=info:doi/10.1111%2Fj.1399-5618.2007.00472.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-10 N1 - Date created - 2008-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1399-5618.2007.00472.x ER - TY - JOUR T1 - Sphingosine can pre- and post-condition heart and utilizes a different mechanism from sphingosine 1-phosphate. AN - 69129096; 18418901 AB - Consistent with previous reports, sphingosine at a high concentration (5 microM) was cardiotoxic as evidenced by increased infarct size in response to ischemia/reperfusion in an ex vivo rat heart. Sphingosine 1-phosphate (S1P) at 5 microM was cardioprotective. However, at a physiologic concentration (0.4 microM) sphingosine as well as S1P was effective in protecting the heart from ischemia/reperfusion injury both when perfused prior to 40 min of ischemia (preconditioning) or when added to reperfusion media following ischemia (postconditioning). Protection by sphingosine and S1P was evidenced with both pre- and post-conditioning by a >75% recovery of left ventricular developed pressure during reperfusion and a decrease in infarct size from 45% of the risk area to less than 8%. When VPC23019, an S1P(1and3)G-protein coupled receptor antagonist, was added to the preconditioning or postconditioning medium along with S1P, it completely blocked S1P-induced protection. However, VPC 23019 did not affect the ability of 0.4 microM sphingosine to either precondition or postcondition hearts. Studies of preconditioning revealed that inhibition of protein kinase C with GF109203X blocked preconditioning by S1P. However, GF109203X did not affect preconditioning by 0.4 microM sphingosine. Likewise, cotreatment with the PI3 kinase inhibitor wortmanin blocked preconditioning by S1P but not by sphingosine. By contrast, inhibition of protein kinase G with KT5823 had no effect on S1P preconditioning but completely eliminated preconditioning by sphingosine. Also, the protein kinase A inhibitory peptide 14-22 amide blocked preconditioning by sphingosine but not S1P. These data reveal for the first time that sphingosine is not toxic at physiologic concentrations but rather is a potent cardioprotectant that utilizes a completely different mechanism than S1P; one that is independent of G-protein coupled receptors and utilizes cyclic nucleotide-dependent pathways. 2008 Wiley Periodicals, Inc. JF - Journal of biochemical and molecular toxicology AU - Vessey, Donald A AU - Li, Luyi AU - Kelley, Michael AU - Zhang, Jianqing AU - Karliner, Joel S AD - Liver Study Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA. donald.vessey@va.gov PY - 2008 SP - 113 EP - 118 VL - 22 IS - 2 KW - Cardiotonic Agents KW - 0 KW - Indoles KW - Lysophospholipids KW - Maleimides KW - Protein Kinase Inhibitors KW - sphingosine 1-phosphate KW - 26993-30-6 KW - bisindolylmaleimide I KW - L79H6N0V6C KW - Sphingosine KW - NGZ37HRE42 KW - Index Medicus KW - Rats KW - Animals KW - Protein Kinase Inhibitors -- pharmacology KW - Indoles -- pharmacology KW - Cardiotonic Agents -- pharmacology KW - Maleimides -- pharmacology KW - Sphingosine -- antagonists & inhibitors KW - Ischemic Preconditioning, Myocardial KW - Lysophospholipids -- pharmacology KW - Sphingosine -- pharmacology KW - Sphingosine -- analogs & derivatives KW - Lysophospholipids -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69129096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biochemical+and+molecular+toxicology&rft.atitle=Sphingosine+can+pre-+and+post-condition+heart+and+utilizes+a+different+mechanism+from+sphingosine+1-phosphate.&rft.au=Vessey%2C+Donald+A%3BLi%2C+Luyi%3BKelley%2C+Michael%3BZhang%2C+Jianqing%3BKarliner%2C+Joel+S&rft.aulast=Vessey&rft.aufirst=Donald&rft.date=2008-03-01&rft.volume=22&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Journal+of+biochemical+and+molecular+toxicology&rft.issn=1099-0461&rft_id=info:doi/10.1002%2Fjbt.20227 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-14 N1 - Date created - 2008-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jbt.20227 ER - TY - JOUR T1 - Attachment organization in Vietnam combat veterans with posttraumatic stress disorder. AN - 68089301; 18351493 AB - Attachment organization in a combat-related PTSD sample was investigated and compared with previously published clinical and non-clinical samples. The association between insecure attachment and unresolved mourning classification (U-loss) and between U-loss and PTSD symptoms was investigated. Vietnam combat veterans diagnosed with PTSD and in treatment (N = 48) were administered the Adult Attachment Interview, the SCID-IV, and CAPS. The PTSD sample was like non-clinical samples in the incidence of secure attachment (50%), but were more commonly unresolved. Veterans with insecure attachment organizations were more likely than those with secure attachment to be classified U-loss. U-loss classification was associated with greater likelihood of comorbid anxiety disorders and PTSD avoidance/numbing symptoms. The results suggest that while insecure attachment organization is associated with unresolved mourning in response to loss, it is not differentially associated with combat-related PTSD. The relationship between U-loss and PTSD is discussed in light of current literature. JF - Attachment & human development AU - Nye, Ella C AU - Katzman, Jeffrey AU - Bell, Jordan B AU - Kilpatrick, Julie AU - Brainard, Marythelma AU - Haaland, Kathleen Y AD - Behavioral Health Care Line, New Mexico VA Health Care System, Albuquerque, USA. Ella.nye@va.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 41 EP - 57 VL - 10 IS - 1 SN - 1461-6734, 1461-6734 KW - Index Medicus KW - Severity of Illness Index KW - Interview, Psychological KW - Anxiety Disorders -- etiology KW - Dysthymic Disorder -- psychology KW - Anxiety Disorders -- psychology KW - Humans KW - Substance-Related Disorders -- etiology KW - Vietnam Conflict KW - Middle Aged KW - Dysthymic Disorder -- etiology KW - Substance-Related Disorders -- psychology KW - Male KW - Comorbidity KW - Bereavement KW - Object Attachment KW - Combat Disorders -- psychology KW - Stress Disorders, Post-Traumatic -- psychology KW - Veterans -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68089301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Attachment+%26+human+development&rft.atitle=Attachment+organization+in+Vietnam+combat+veterans+with+posttraumatic+stress+disorder.&rft.au=Nye%2C+Ella+C%3BKatzman%2C+Jeffrey%3BBell%2C+Jordan+B%3BKilpatrick%2C+Julie%3BBrainard%2C+Marythelma%3BHaaland%2C+Kathleen+Y&rft.aulast=Nye&rft.aufirst=Ella&rft.date=2008-03-01&rft.volume=10&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Attachment+%26+human+development&rft.issn=14616734&rft_id=info:doi/10.1080%2F14616730701868613 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-09 N1 - Date created - 2008-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/14616730701868613 ER - TY - JOUR T1 - Respiratory and Cardiac Manifestations of Obstructive Sleep Apnea AN - 57302279; 200915673 AB - Obstructive sleep apnea hypopnea syndrome (OSAHS) is largely under-diagnosed and unrecognized by primary care practitioners. Insidious changes within the respiratory and cardiovascular systems occur over time in untreated OSAHS. Respiratory manifestations of OSAHS include changes in the hypoxic ventilatory response, which can lead to long-term facilitation of ventilation in breathing and production of oxidative stress. Cardiovascular manifestations of OSAHS include increased sympathetic activity, endothelial dysfunction, and over-production of inflammatory cytokines. These changes are likely responsible for many of the pathologic sequelae associated with OSAHS. [Copyright Elsevier B.V.] JF - Nursing Clinics of North America AU - Lee, Dorothy S AD - College of Nursing, Wayne State University, Detroit, MI 48202, USA dorothy.lee1@va.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 55 EP - 76 PB - Elsevier Ltd, The Netherlands VL - 43 IS - 1 SN - 0029-6465, 0029-6465 KW - Breathing KW - Cardiovascular system KW - Oxidative stress KW - Sleep apnoea KW - Primary health care KW - Dysfunction KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57302279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Clinics+of+North+America&rft.atitle=Respiratory+and+Cardiac+Manifestations+of+Obstructive+Sleep+Apnea&rft.au=Lee%2C+Dorothy+S&rft.aulast=Lee&rft.aufirst=Dorothy&rft.date=2008-03-01&rft.volume=43&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Nursing+Clinics+of+North+America&rft.issn=00296465&rft_id=info:doi/10.1016%2Fj.cnur.2007.11.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Sleep apnoea; Dysfunction; Cardiovascular system; Primary health care; Oxidative stress; Breathing DO - http://dx.doi.org/10.1016/j.cnur.2007.11.002 ER - TY - JOUR T1 - Empirical Correlates of the MMPI-2 Restructured Clinical (RC) Scales in Psychiatric Inpatients AN - 57244377; 200813179 AB - We identified empirical correlates of the MMPI-2 Restructured Clinical (RC) scales in 1,872 male and 498 female psychiatric inpatients drawn from 2 large tertiary care medical centers. We generated clinical criteria from a systematic review of the patients' intake and discharge medical records. We report zero order correlations between RC scales and clinical criteria and relative risk ratios for dichotomous variables. We found the RC scales to be correlated with conceptually relevant criteria such that for each scale, we identified significant increases in the risk for a variety of emotional, cognitive, and behavioral problems among individuals whose T score exceed 64. Adapted from the source document. JF - Journal of Personality Assessment AU - Arbisi, Paul A AU - Sellbom, Martin AU - Ben-Porath, Yossef S AD - Minneapolis Veterans Administration Medical Center, University of Minnesota Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 122 EP - 128 PB - Lawrence Erlbaum Associates, Mahwah NJ VL - 90 IS - 2 SN - 0022-3891, 0022-3891 KW - Minnesota Multiphasic Personality Inventory-2 KW - Men KW - Psychiatric hospitals KW - Medical records KW - Behavioural problems KW - T scores KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57244377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+Assessment&rft.atitle=Empirical+Correlates+of+the+MMPI-2+Restructured+Clinical+%28RC%29+Scales+in+Psychiatric+Inpatients&rft.au=Arbisi%2C+Paul+A%3BSellbom%2C+Martin%3BBen-Porath%2C+Yossef+S&rft.aulast=Arbisi&rft.aufirst=Paul&rft.date=2008-03-01&rft.volume=90&rft.issue=2&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+Assessment&rft.issn=00223891&rft_id=info:doi/10.1080%2F00223890701845146 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-27 N1 - Last updated - 2016-09-27 N1 - CODEN - JNPABU N1 - SubjectsTermNotLitGenreText - Psychiatric hospitals; Minnesota Multiphasic Personality Inventory-2; T scores; Behavioural problems; Men; Medical records DO - http://dx.doi.org/10.1080/00223890701845146 ER - TY - JOUR T1 - Regional Foot Pressure During Running, Cutting, Jumping, and Landing AN - 20754174; 8033574 AB - BACKGROUND: Evaluating shoes during sport-related movements may provide a better assessment of plantar loads associated with repetitive injury and provide more specific data for comparing shoe cushioning characteristics. HYPOTHESIS: Accelerating, cutting, and jumping pressures will be higher than in straight running, differentiating regional shoe cushioning performance in sport-specific movements. STUDY DESIGN: Controlled laboratory study. MATERIALS AND METHODS: Peak pressures on seven anatomic regions of the foot were assessed in 10 male college athletes during running straight ahead, accelerating, cutting left, cutting right, jump take-off, and jump landing wearing Speed TD and Air Pro Turf Low shoes (Nike, Beaverton, Ore). Pedar insoles (Novel, Munich, Germany) were sampled at 99 Hz during the 6 movements. RESULTS: Cutting and jumping movements demonstrated more than double the pressure at the heel compared with running straight, regardless of shoe type. The Air Pro Turf showed overall lower pressure for all movement types (P<.0377). Cutting to the left, the Air Pro Turf shoe had lower heel pressures (36.6 plus or minus 12.5 N/cm super(2)) than the Speed TD (50.3 plus or minus 11.2 N/cm super(2)) (P<.0001), and the Air Pro Turf had lower great toe pressures than the Speed TD (44.8 plus or minus 8.1 N/cm super(2) vs 54.4 plus or minus 8.4 N/cm super(2); P= .0002). The Air Pro Turf also had significantly lower pressures than the Speed TD at the central forefoot during acceleration (38.2 plus or minus 8.3 N/cm super(2) vs 50.8 plus or minus 7.4 N/cm super(2); P<.0001). CONCLUSION: Sport-related movements load the plantar surface of the foot more than running straight. Shoe cushioning characteristics were more robustly assessed during sport-related movements (4 significant results detected) compared with running straight (1 significant result detected). Clinical Relevance: There is an interaction between shoe cushioning characteristics and sport-related movements that may influence plantar pressure and repetitive stress injuries. JF - American Journal of Sports Medicine AU - Orendurff, Michael S AU - Rohr, Eric S AU - Segal, Ava D AU - Medley, Jonathan W AU - Green, John RIII AU - Kadel, Nancy J AD - Motion Analysis Laboratory, Center of Excellence for Limb Loss Prevention & Prosthetic Engineering, Rehabilitation Research & Development, Veterans Administration Hospital, Seattle, Washington, and the Department of Rehabilitation Medicine and Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 566 EP - 571 PB - American Orthopaedic Society of Sports Medicine, 230 Calvary Street Waltham MA 02453 USA, [URL:http://www.sportsmed.org/default.htm] VL - 36 IS - 3 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Speed KW - Jumping KW - Feet KW - Running KW - Stress KW - Shoes KW - Running (shoes) KW - Movement KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20754174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Regional+Foot+Pressure+During+Running%2C+Cutting%2C+Jumping%2C+and+Landing&rft.au=Orendurff%2C+Michael+S%3BRohr%2C+Eric+S%3BSegal%2C+Ava+D%3BMedley%2C+Jonathan+W%3BGreen%2C+John+RIII%3BKadel%2C+Nancy+J&rft.aulast=Orendurff&rft.aufirst=Michael&rft.date=2008-03-01&rft.volume=36&rft.issue=3&rft.spage=566&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Jumping; Speed; Feet; Running; Stress; Shoes; Running (shoes); Movement ER - TY - JOUR T1 - Mortality Patterns Among Women Vietnam-Era Veterans: Results of a Retrospective Cohort Study AN - 20562664; 9272830 AB - Purpose This research compiled and analyzed the data of two cohorts of women veterans who either served in Vietnam ('Vietnam veteran' cohort, n = 4586) or served elsewhere during the Vietnam War ('non-Vietnam veteran' cohort, n = 5325). All cause and cause-specific mortality were compared between Vietnam and non-Vietnam veteran cohorts, to the U.S. population, and to earlier research. Similar analyses were performed for nurses only. Methods Vital status was determined through December 31, 2004, using primarily the U.S. Department of Veterans Affairs beneficiary file and the Social Security Administration Death Master File. Selected data were submitted to the National Center for Health Statistics for merging with the National Death Index to obtain cause of death. Cox proportional hazard analysis modeling was used to obtain adjusted relative risks (ARR). SEER*Stat software was used to compute standardized mortality ratios (SMR) for comparisons to the U.S. population. Results Women Vietnam veterans showed a significant deficit (ARR = 0.78, 95% confidence interval [CI] 0.62-0.98) in circulatory system disease relative to non-Vietnam veterans, but significant deficits also were observed when the Vietnam and non-Vietnam cohorts were each compared with women in the U.S. population (SMR = 0.65, 95% CI 0.54-0.77; SMR=0.82, 95% CI 0.73-0.93, respectively). Vietnam veterans had significantly lower mortality than women in the U.S. population for all causes (SMR = 0.87, 95% CI 0.80-0.94). Vietnam veterans were at significantly greater risk of mortality from motor vehicle accidents than non-Vietnam veterans (ARR = 2.60, 95% CI 1.22-5.55) and this appeared to be specific to service in Vietnam based on comparisons to the U.S. population. Patterns did not differ greatly for the analysis on nurse veterans or to earlier mortality studies of these cohorts. Conclusion Mortality from motor vehicle accidents was significantly associated with service in Vietnam. Mortality patterns generally resembled those reported on in the past. Key Words: Veterans; Women's Health; Vietnam Conflict; Mortality Abbreviations: SSA, Social Security Administration; BIRLS, Beneficiary Identification and Records Locator Subsystem; NDI, National Death Index; ICD, International Classification of Diseases; CNS, central nervous system; ARR, adjusted relative risk; 95% CI, 95% confidence interval; SMR, standardized mortality ratio; SEER, Surveillance, Epidemiology, and End Results JF - Annals of Epidemiology AU - Cypel, Yasmin AU - Kang, Han AD - War-Related Illness and Injury Study Center (WRIISC), Veterans Affairs Medical Center, yasmin.cypel@va.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 244 EP - 252 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 18 IS - 3 SN - 1047-2797, 1047-2797 KW - Risk Abstracts KW - conflicts KW - Central nervous system KW - Mortality KW - Motor vehicles KW - Mortality patterns KW - war KW - Medical personnel KW - Vietnam KW - Computer programs KW - USA KW - Accidents KW - classification KW - Standards KW - Females KW - nursing KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20562664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Mortality+Patterns+Among+Women+Vietnam-Era+Veterans%3A+Results+of+a+Retrospective+Cohort+Study&rft.au=Cypel%2C+Yasmin%3BKang%2C+Han&rft.aulast=Cypel&rft.aufirst=Yasmin&rft.date=2008-03-01&rft.volume=18&rft.issue=3&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2007.11.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - conflicts; Mortality; Central nervous system; Motor vehicles; Mortality patterns; Medical personnel; war; Computer programs; Accidents; classification; Standards; Females; nursing; USA; Vietnam DO - http://dx.doi.org/10.1016/j.annepidem.2007.11.009 ER - TY - JOUR T1 - A decision support system to facilitate management of patients with acute gastrointestinal bleeding AN - 20544560; 8101701 AB - Objective: To develop a model to predict the bleeding source and identify the cohort amongst patients with acute gastrointestinal bleeding (GIB) who require urgent intervention, including endoscopy. Patients with acute GIB, an unpredictable event, are most commonly evaluated and managed by non-gastroenterologists. Rapid and consistently reliable risk stratification of patients with acute GIB for urgent endoscopy may potentially improve outcomes amongst such patients by targeting scarce healthcare resources to those who need it the most. Design and methods: Using ICD-9 codes for acute GIB, 189 patients with acute GIB and all available data variables required to develop and test models were identified from a hospital medical records database. Data on 122 patients was utilized for development of the model and on 67 patients utilized to perform comparative analysis of the models. Clinical data such as presenting signs and symptoms, demographic data, presence of co-morbidities, laboratory data and corresponding endoscopic diagnosis and outcomes were collected. Clinical data and endoscopic diagnosis collected for each patient was utilized to retrospectively ascertain optimal management for each patient. Clinical presentations and corresponding treatment was utilized as training examples. Eight mathematical models including artificial neural network (ANN), support vector machine (SVM), k-nearest neighbor, linear discriminant analysis (LDA), shrunken centroid (SC), random forest (RF), logistic regression, and boosting were trained and tested. The performance of these models was compared using standard statistical analysis and ROC curves. Results: Overall the random forest model best predicted the source, need for resuscitation, and disposition with accuracies of approximately 80% or higher (accuracy for endoscopy was greater than 75%). The area under ROC curve for RF was greater than 0.85, indicating excellent performance by the random forest model. Conclusion: While most mathematical models are effective as a decision support system for evaluation and management of patients with acute GIB, in our testing, the RF model consistently demonstrated the best performance. Amongst patients presenting with acute GIB, mathematical models may facilitate the identification of the source of GIB, need for intervention and allow optimization of care and healthcare resource allocation; these however require further validation. JF - Artificial Intelligence in Medicine AU - Chu, A AU - Ahn, H AU - Halwan, B AU - Kalmin, B AU - Artifon, ELA AU - Barkun, A AU - Lagoudakis, M G AU - Kumar, A AD - Stony Brook University, Stony Brook, NY 11794, United States, atul.kumar2@va.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 247 EP - 259 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 42 IS - 3 SN - 0933-3657, 0933-3657 KW - Biotechnology and Bioengineering Abstracts KW - Demography KW - Databases KW - Mathematical models KW - Neural networks KW - medical records KW - Bleeding KW - Statistical analysis KW - Forests KW - Disposition KW - Endoscopy KW - Hospitals KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20544560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Artificial+Intelligence+in+Medicine&rft.atitle=A+decision+support+system+to+facilitate+management+of+patients+with+acute+gastrointestinal+bleeding&rft.au=Chu%2C+A%3BAhn%2C+H%3BHalwan%2C+B%3BKalmin%2C+B%3BArtifon%2C+ELA%3BBarkun%2C+A%3BLagoudakis%2C+M+G%3BKumar%2C+A&rft.aulast=Chu&rft.aufirst=A&rft.date=2008-03-01&rft.volume=42&rft.issue=3&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Artificial+Intelligence+in+Medicine&rft.issn=09333657&rft_id=info:doi/10.1016%2Fj.artmed.2007.10.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Demography; Databases; Mathematical models; medical records; Neural networks; Statistical analysis; Bleeding; Forests; Disposition; Hospitals; Endoscopy DO - http://dx.doi.org/10.1016/j.artmed.2007.10.003 ER - TY - JOUR T1 - Are treated alcoholics representative of the entire population with alcohol use disorders? A magnetic resonance study of brain injury AN - 19686249; 8602101 AB - Almost all we know about neurobiological brain injury in alcohol use disorders has been derived from convenience samples of treated alcoholics. Recent research has demonstrated more comorbid conditions, poorer psychosocial functioning, and higher dependence levels in treated alcoholics than in their treatment-naive counterparts. Thus, it is not clear whether neuroimaging results from convenience samples of treated alcoholics can be generalized to the entire population with alcohol use disorders. We compared 35 treated alcoholics at 1 week of abstinence (ALC) and 32 treatment-naive heavy drinkers (HD) on regional brain volumes and metabolite concentrations obtained by in vivo magnetic resonance at 1.5 Tesla to evaluate for potential group differences. Then, we evaluated whether comorbid cigarette smoking and common demographic and clinical variables mediated any existing neurobiological group differences. ALC demonstrated smaller lobar gray matter volumes and thalami than HD, exacerbated by chronic smoking. Furthermore, concentrations of N-acetyl-aspartate (an accepted marker of neuronal viability), choline-containing metabolites (involved in membrane turnover), and myo-inositol (a putative marker of glial cells and osmolyte) were lower in multiple brain regions of ALC compared to HD. The lower N-acetyl- aspartate concentrations in white matter of ALC versus HD were explained by average number of drinks per month over the year preceding study. However, the other group differences were not explained by common drinking, demographic, and clinical variables (used as covariates at the same time) or by excluding participants with comorbid mood disorders. Taken together, this suggests that the degree of brain atrophy, as well as neuronal and membrane injury in clinical samples of alcoholics cannot be generalized to the much larger population with alcohol use disorders that does not seek treatment. JF - Alcohol AU - Gazdzinski, Stefan AU - Durazzo, Timothy C AU - Weiner, Michael W AU - Meyerhoff, Dieter J AD - Center for Imaging of Neurodegenerative Diseases (CIND), Veterans Administration Medical Center, San Francisco, CA, USA, stefan.gazdzinski@ucsf.edu Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 67 EP - 76 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 42 IS - 2 SN - 0741-8329, 0741-8329 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Alcohol use disorder KW - Treatment KW - Structural MRI KW - MR spectroscopy KW - Brain KW - Neuroimaging KW - Beverages KW - Brain injury KW - Membrane turnover KW - Glial cells KW - Substantia alba KW - Metabolites KW - Alcoholics KW - Social interactions KW - Mood KW - Demography KW - Cigarette smoking KW - Drinking behavior KW - N.M.R. KW - Atrophy KW - Substantia grisea KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19686249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol&rft.atitle=Are+treated+alcoholics+representative+of+the+entire+population+with+alcohol+use+disorders%3F+A+magnetic+resonance+study+of+brain+injury&rft.au=Gazdzinski%2C+Stefan%3BDurazzo%2C+Timothy+C%3BWeiner%2C+Michael+W%3BMeyerhoff%2C+Dieter+J&rft.aulast=Gazdzinski&rft.aufirst=Stefan&rft.date=2008-03-01&rft.volume=42&rft.issue=2&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/10.1016%2Fj.alcohol.2008.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Membrane turnover; Brain injury; Beverages; Glial cells; Substantia alba; Metabolites; Alcoholics; Social interactions; Demography; Mood; Cigarette smoking; Drinking behavior; Atrophy; N.M.R.; Ethanol; Substantia grisea DO - http://dx.doi.org/10.1016/j.alcohol.2008.01.002 ER - TY - JOUR T1 - Epidemiology of Hospital-Acquired Infections in Veterans With Spinal Cord Injury and Disorder AN - 19608077; 8585044 AB - Objective. To describe the epidemiology of hospital-acquired infections (HAIs) in veterans with spinal cord injury and disorder (SCI&D). Design. Retrospective medical record review. Setting. Midwestern Department of Veterans Affairs spinal cord injury center. Participants. A total of 226 patients with SCI&D hospitalized at least once during a 2-year period (October 1, 2001, through September 30, 2003). Results. A total of 549 hospitalizations were included in the analysis (mean duration of hospitalization, 33.7 days); an HAI occurred during 182 (33.2%) of these hospitalizations. A total of 657 HAIs occurred during 18,517 patient-days in the hospital (incidence rate, 35.5 HAIs per 1,000 patient-days). Almost half of the 226 patients had at least 1 HAI; the mean number of HAIs among these patients was 6.0 HAIs per patient. The most common HAIs were urinary tract infection (164 [25.0%] of the 657 HAIs; incidence rate, 8.9 cases per 1,000 patient-days), bloodstream infection (111 [16.9%]; incidence rate, 6.0 cases per 1,000 patient-days), and bone and joint infection (103 [15.7%]; incidence rate, 5.6 cases per 1,000 patient-days). The most common culture isolates were gram-positive bacteria (1,082 [45.6%] of 2,307 isolates), including Staphylococcus aureus, and gram-negative bacteria (1,033 [43.6%] of isolates), including Pseudomonas aeruginosa. Multivariable regression demonstrated that predictors of HAI were longer length of hospital stay (P =.002), community-acquired infection (P =.007), and use of a urinary invasive device (P =.01) or respiratory invasive device (P =.04). Conclusions. The overall incidence of HAIs in persons with SCI&D was higher than that reported for other populations, confirming the increased risk of HAI in persons with spinal cord injury. The increased risk associated with longer length of stay and with community-acquired infection suggests that strategies are needed to reduce the duration of hospitalization and to effectively treat community-acquired infection, to decrease infection rates. There is significant room for improvement in reducing the incidence of HAIs in this population. JF - Infection Control and Hospital Epidemiology AU - Evans, Charlesnika T AU - LaVela, Sherri L AU - Weaver, Frances M AU - Priebe, Michael AU - Sandford, Paul AU - Niemiec, Pamela AU - Miskevics, Scott AU - Parada, Jorge P AD - Department of Veterans Affairs, Spinal Cord Injury Quality Enhancement Research Initiative, Center for Management of Complex Chronic Care, and the Infection Control Section, Edward Hines Jr Veterans Affairs Hospital, Hines, Charlesnika.Evans@va.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 234 EP - 242 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 29 IS - 3 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - Injuries KW - medical records KW - Gram-positive bacteria KW - Joint diseases KW - Spinal cord injury KW - Urinary tract KW - Infection KW - Bone KW - Epidemiology KW - Reviews KW - Gram-negative bacteria KW - infection KW - Severe combined immunodeficiency KW - Pseudomonas aeruginosa KW - Staphylococcus aureus KW - Hospitals KW - A 01450:Environmental Pollution & Waste Treatment KW - R2 23060:Medical and environmental health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19608077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Epidemiology+of+Hospital-Acquired+Infections+in+Veterans+With+Spinal+Cord+Injury+and+Disorder&rft.au=Evans%2C+Charlesnika+T%3BLaVela%2C+Sherri+L%3BWeaver%2C+Frances+M%3BPriebe%2C+Michael%3BSandford%2C+Paul%3BNiemiec%2C+Pamela%3BMiskevics%2C+Scott%3BParada%2C+Jorge+P&rft.aulast=Evans&rft.aufirst=Charlesnika&rft.date=2008-03-01&rft.volume=29&rft.issue=3&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F527509 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bone; Epidemiology; medical records; Gram-positive bacteria; Gram-negative bacteria; Joint diseases; Severe combined immunodeficiency; Urinary tract; Spinal cord injury; Infection; Hospitals; Injuries; Reviews; infection; Staphylococcus aureus; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1086/527509 ER - TY - JOUR T1 - Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics. AN - 70256201; 18178068 AB - Memory function is largely mediated by the medial temporal lobe (MTL), and its compromise has been observed in alcohol dependence and chronic cigarette smoking. The effects of heavy alcohol consumption and chronic smoking on hippocampal volumes and MTL metabolites and their recovery during abstinence from alcohol have not been assessed. Male alcoholics in treatment (ALC) [13 smokers (sALC) and 11 non-smokers (nsALC)] underwent quantitative magnetic resonance imaging and short-echo proton magnetic resonance spectroscopic imaging at 1 week and 1 month of sobriety. Outcome measures were compared with 14 age-matched, non-smoking light-drinkers and were related to visuospatial learning and memory. Over 1 month of abstinence, N-acetyl-aspartate, a neuronal marker, and membrane-associated choline-containing metabolites normalized in the MTL of nsALC subjects, but remained low in the MTL of sALC subjects. Metabolite concentration changes in both groups were associated with improvements in visuospatial memory. Hippocampal volumes increased in both groups during abstinence, but increasing volumes correlated with visuospatial memory improvements only in nsALC subjects. In summary, chronic cigarette smoking in alcohol-dependent men appears to have adverse effects on MTL metabolite recovery during short-term sobriety. These data may also have implications for other conditions with established MTL involvement and significant smoking co-morbidity, such as schizophrenia-spectrum and mood disorders. JF - Psychiatry research AU - Gazdzinski, Stefan AU - Durazzo, Timothy C AU - Yeh, Ping-Hong AU - Hardin, Dawn AU - Banys, Peter AU - Meyerhoff, Dieter J AD - Magnetic Resonance Unit, San Francisco Veterans Administration Medical Center, San Francisco, CA 94121, United States. spg@itsa.ucsf.edu Y1 - 2008/02/28/ PY - 2008 DA - 2008 Feb 28 SP - 133 EP - 145 VL - 162 IS - 2 SN - 0165-1781, 0165-1781 KW - Aspartic Acid KW - 30KYC7MIAI KW - N-acetylaspartate KW - 997-55-7 KW - Choline KW - N91BDP6H0X KW - Index Medicus KW - Aspartic Acid -- metabolism KW - Dominance, Cerebral -- physiology KW - Humans KW - Choline -- metabolism KW - Aged KW - Cross-Sectional Studies KW - Aspartic Acid -- analogs & derivatives KW - Mental Recall -- physiology KW - Adult KW - Hippocampus -- physiopathology KW - Middle Aged KW - Atrophy KW - Hippocampus -- pathology KW - Neuropsychological Tests KW - Alcoholism -- rehabilitation KW - Magnetic Resonance Imaging KW - Alcohol Amnestic Disorder -- rehabilitation KW - Alcoholism -- pathology KW - Alcohol Amnestic Disorder -- physiopathology KW - Energy Metabolism -- physiology KW - Alcohol Amnestic Disorder -- pathology KW - Smoking -- adverse effects KW - Magnetic Resonance Spectroscopy KW - Temporal Lobe -- pathology KW - Alcoholism -- physiopathology KW - Image Processing, Computer-Assisted KW - Temporal Lobe -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70256201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Chronic+cigarette+smoking+modulates+injury+and+short-term+recovery+of+the+medial+temporal+lobe+in+alcoholics.&rft.au=Gazdzinski%2C+Stefan%3BDurazzo%2C+Timothy+C%3BYeh%2C+Ping-Hong%3BHardin%2C+Dawn%3BBanys%2C+Peter%3BMeyerhoff%2C+Dieter+J&rft.aulast=Gazdzinski&rft.aufirst=Stefan&rft.date=2008-02-28&rft.volume=162&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/10.1016%2Fj.pscychresns.2007.04.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-16 N1 - Date created - 2008-02-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jan;29(1):97-107 [15610951] J Psychiatry Neurosci. 2004 Nov;29(6):417-26 [15644983] Pharmacol Rev. 2005 Mar;57(1):79-115 [15734728] Psychiatry Res. 2005 Feb 28;138(2):115-30 [15766635] Drug Alcohol Depend. 2005 Jun 1;78(3):235-41 [15893154] Soc Sci Med. 2005 Jul;61(2):293-303 [15893046] J Clin Invest. 2005 Jul;115(7):1888-95 [15951840] Biol Psychiatry. 2005 Jul 15;58(2):143-50 [16038685] Alcohol Clin Exp Res. 2005 Aug;29(8):1484-95 [16131857] Alcohol Clin Exp Res. 2005 Aug;29(8):1504-13 [16156047] J Neural Transm (Vienna). 2005 Nov;112(11):1475-8 [16245069] Nat Neurosci. 2005 Nov;8(11):1465-70 [16251989] Biol Psychiatry. 2005 Dec 15;58(12):974-80 [16084857] Subst Use Misuse. 2006;41(3):265-81 [16467005] Alcohol Clin Exp Res. 2006 Mar;30(3):539-51 [16499496] Am J Drug Alcohol Abuse. 2006;32(2):135-48 [16595320] Addict Behav. 2006 May;31(5):833-44 [16009504] Alcohol Clin Exp Res. 2006 Jun;30(6):947-58 [16737452] Alcohol Clin Exp Res. 2006 Nov;30(11):1866-70 [17067350] Biol Psychiatry. 2007 Jan 1;61(1):41-7 [16533498] J Clin Psychopharmacol. 2007 Feb;27(1):80-4 [17224719] J Stud Alcohol. 1988 May;49(3):225-32 [3374136] Brain Res. 1988 Sep 6;459(2):381-5 [3179712] Brain Res. 1988 Nov 8;473(1):1-14 [3208112] Brain Res. 1989 Jan 16;477(1-2):373-7 [2467727] Exp Neurol. 1989 Nov;106(2):156-63 [2478383] Ear Nose Throat J. 1990 Nov;69(11):763-5 [2276350] Alcohol Clin Exp Res. 1994 Aug;18(4):867-72 [7978097] Alcohol Clin Exp Res. 1995 Feb;19(1):110-22 [7771636] Alcohol Clin Exp Res. 1995 Aug;19(4):1078-82 [7485820] Acta Psychiatr Scand. 1995 Aug;92(2):87-90 [7572265] Alcohol Clin Exp Res. 1995 Oct;19(5):1177-91 [8561288] Neurobiol Aging. 1999 May-Jun;20(3):279-85 [10588575] Behav Brain Res. 2000 May;109(2):177-86 [10762687] Alcohol Clin Exp Res. 2000 May;24(5):611-21 [10832902] Alcohol Clin Exp Res. 2000 May;24(5):699-705 [10832912] Alcohol Clin Exp Res. 2000 Oct;24(10):1583-92 [11045868] Biol Psychiatry. 2001 Feb 1;49(3):258-67 [11230877] Anat Rec. 2001 Apr15;265(2):54-84 [11323770] Magn Reson Med. 2001 May;45(5):899-907 [11323817] Alcohol Clin Exp Res. 2001 Jun;25(6):924-34 [11410730] Drug Alcohol Depend. 2001 Aug 1;63(3):277-86 [11418232] AJNR Am J Neuroradiol. 2001 Nov-Dec;22(10):1926-32 [11733327] Biol Psychiatry. 2001 Dec 15;50(12):952-9 [11750891] J Neurosci. 2002 May 1;22(9):3656-62 [11978841] J Magn Reson Imaging. 2002 Sep;16(3):305-10 [12205587] Alcohol Clin Exp Res. 2002 Sep;26(9):1368-80 [12351932] Prog Brain Res. 2002;138:315-42 [12432777] Alcohol Alcohol. 2003 Jan-Feb;38(1):40-4 [12554606] Am J Public Health. 2003 Jun;93(6):994-8 [12773367] J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):1006-7 [12810811] J Int Neuropsychol Soc. 2003 Jul;9(5):690-7 [12901775] Age Ageing. 2003 Sep;32(5):548-50 [12958006] Psychol Med. 2003 Nov;33(8):1357-67 [14672244] Free Radic Biol Med. 2003 Dec 15;35(12):1582-8 [14680681] Biol Psychiatry. 2004 Jan 1;55(1):77-84 [14706428] Biomed Pharmacother. 2004 Mar;58(2):77-83 [14992787] Curr Opin Pharmacol. 2004 Feb;4(1):36-46 [15018837] Curr Opin Neurobiol. 2004 Apr;14(2):186-91 [15082323] Alcohol Clin Exp Res. 2004 Apr;28(4):650-61 [15100618] Am J Geriatr Psychiatry. 2004 Jul-Aug;12(4):404-11 [15249278] J Neurosci. 2004 Oct 27;24(43):9714-22 [15509760] Am J Psychiatry. 2004 Nov;161(11):1957-66 [15514393] J Stud Alcohol. 1982 Nov;43(11):1157-70 [7182675] J Comp Neurol. 1984 May 1;225(1):111-8 [6539344] Behav Brain Res. 1995 Nov;71(1-2):1-10 [8747170] Behav Brain Res. 1996 Jun;78(1):25-36 [8793034] Magn Reson Imaging. 1996;14(5):553-7 [8843367] Hippocampus. 1997;7(1):78-87 [9138671] Eur J Nucl Med. 1997 Apr;24(4):422-7 [9096094] J Addict Dis. 1997;16(3):19-24 [9243336] J Neurol Sci. 1997 Nov 6;152(1):39-49 [9395125] Psychopharmacology (Berl). 1998 Aug;138(3-4):217-30 [9725745] Cereb Cortex. 1998 Dec;8(8):710-8 [9863698] Alcohol Clin Exp Res. 1999 Jan;23(1):158-63 [10029218] Alcohol Clin Exp Res. 1999 Jan;23(1):164-8 [10029219] Arch Gen Psychiatry. 1999 Apr;56(4):356-63 [10197833] Am J Psychiatry. 2004 Dec;161(12):2194-200 [15569889] J Psychopharmacol. 2004 Dec;18(4):457-74 [15582913] Alcohol Clin Exp Res. 2004 Dec;28(12):1849-60 [15608601] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.pscychresns.2007.04.003 ER - TY - CPAPER T1 - Processing Speed and Functional Decline in Older Cancer Survivors. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40793690; 4790216 JF - 36th Annual International Neuropsychological Society Meeting AU - McGee, J S AU - Kvale, E A AU - Clay, O J AU - Ross, L A AU - Edwards, J D AU - Unverzagt, F W AU - Ritchie, C S AU - Ball, K K Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40793690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Processing+Speed+and+Functional+Decline+in+Older+Cancer+Survivors.&rft.au=McGee%2C+J+S%3BKvale%2C+E+A%3BClay%2C+O+J%3BRoss%2C+L+A%3BEdwards%2C+J+D%3BUnverzagt%2C+F+W%3BRitchie%2C+C+S%3BBall%2C+K+K&rft.aulast=McGee&rft.aufirst=J&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preliminary Results of a Psychoeducational Group on Age-Related Cognitive Changes. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40792391; 4790283 JF - 36th Annual International Neuropsychological Society Meeting AU - Kraft, M AU - Steadman-Wood, P AU - Chamberlain, A AU - Grande, L AU - McGlinchey, R Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Cognitive ability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40792391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Preliminary+Results+of+a+Psychoeducational+Group+on+Age-Related+Cognitive+Changes.&rft.au=Kraft%2C+M%3BSteadman-Wood%2C+P%3BChamberlain%2C+A%3BGrande%2C+L%3BMcGlinchey%2C+R&rft.aulast=Kraft&rft.aufirst=M&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mediational Effects of Cognitive Reserve on the Relationship between Executive Function and Memory. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40792044; 4790295 JF - 36th Annual International Neuropsychological Society Meeting AU - Barlow, A S AU - Schafer-Johnson, A AU - Axelrod, B N Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Executive function KW - Cognitive ability KW - Memory KW - Potential resources KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40792044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Mediational+Effects+of+Cognitive+Reserve+on+the+Relationship+between+Executive+Function+and+Memory.&rft.au=Barlow%2C+A+S%3BSchafer-Johnson%2C+A%3BAxelrod%2C+B+N&rft.aulast=Barlow&rft.aufirst=A&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Relationship between Executive Functioning and Memory Performance as a Function of Cognitive Reserve. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40791350; 4790294 JF - 36th Annual International Neuropsychological Society Meeting AU - Barlow, A S AU - Axelrod, B N Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Cognitive ability KW - Memory KW - Potential resources KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40791350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=The+Relationship+between+Executive+Functioning+and+Memory+Performance+as+a+Function+of+Cognitive+Reserve.&rft.au=Barlow%2C+A+S%3BAxelrod%2C+B+N&rft.aulast=Barlow&rft.aufirst=A&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Atypical Cognitive Findings in a Case of Probable Sporadic Creutzfeld-Jakob Disease. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40790989; 4790179 JF - 36th Annual International Neuropsychological Society Meeting AU - Cercy, S P AU - Cole, J Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Cognitive ability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40790989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Atypical+Cognitive+Findings+in+a+Case+of+Probable+Sporadic+Creutzfeld-Jakob+Disease.&rft.au=Cercy%2C+S+P%3BCole%2C+J&rft.aulast=Cercy&rft.aufirst=S&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessing Veterans with Mild Brain Trauma and Post Traumatic Stress: Can Neuropsychological Tests Distinguish Cognitive and Emotional Impairments? T2 - 36th Annual International Neuropsychological Society Meeting AN - 40790873; 4790491 JF - 36th Annual International Neuropsychological Society Meeting AU - Poole, J AU - Thomander, D AU - Sim, T AU - Lew, H Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Stress KW - Brain injury KW - Emotions KW - Cognitive ability KW - Traumatic brain injury KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40790873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Assessing+Veterans+with+Mild+Brain+Trauma+and+Post+Traumatic+Stress%3A+Can+Neuropsychological+Tests+Distinguish+Cognitive+and+Emotional+Impairments%3F&rft.au=Poole%2C+J%3BThomander%2C+D%3BSim%2C+T%3BLew%2C+H&rft.aulast=Poole&rft.aufirst=J&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cognitive Dysfunction in a Case of Pre-Treatment Diffuse Large B-Cell Lymphoma. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40789538; 4789782 JF - 36th Annual International Neuropsychological Society Meeting AU - Cercy, S P AU - Bronson, B Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Lymphoma KW - B-cell lymphoma KW - Cognitive ability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40789538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Cognitive+Dysfunction+in+a+Case+of+Pre-Treatment+Diffuse+Large+B-Cell+Lymphoma.&rft.au=Cercy%2C+S+P%3BBronson%2C+B&rft.aulast=Cercy&rft.aufirst=S&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Heterogeneity of Olfactory Processing in Early-Onset Familial Alzheimer Disease due to Presenilin-1 Mutation. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40789346; 4790528 JF - 36th Annual International Neuropsychological Society Meeting AU - Cercy, S P Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Mutation KW - Neurodegenerative diseases KW - Alzheimer's disease KW - Presenilin 1 KW - Age KW - Information processing KW - Olfaction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40789346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Heterogeneity+of+Olfactory+Processing+in+Early-Onset+Familial+Alzheimer+Disease+due+to+Presenilin-1+Mutation.&rft.au=Cercy%2C+S+P&rft.aulast=Cercy&rft.aufirst=S&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship of Neurocognitive Problems to PTSD in Gulf War Veterans. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40789035; 4790347 JF - 36th Annual International Neuropsychological Society Meeting AU - Knight, J A AU - Vogt, D S AU - King, D W AU - King, L A Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Occupational health KW - Military KW - Post-traumatic stress disorder KW - Cognition KW - Gulf War KW - Military personnel KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40789035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Relationship+of+Neurocognitive+Problems+to+PTSD+in+Gulf+War+Veterans.&rft.au=Knight%2C+J+A%3BVogt%2C+D+S%3BKing%2C+D+W%3BKing%2C+L+A&rft.aulast=Knight&rft.aufirst=J&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Profiles of Impairment in Traumatic Brain Injury using the Delis-Kaplan Executive Function System. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40788946; 4790317 JF - 36th Annual International Neuropsychological Society Meeting AU - Poole, J AU - Melissa, S AU - Dahdah, M AU - Bui, M AU - Wager, J AU - Spina, L Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Brain KW - Traumatic brain injury KW - Executive function KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40788946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Profiles+of+Impairment+in+Traumatic+Brain+Injury+using+the+Delis-Kaplan+Executive+Function+System.&rft.au=Poole%2C+J%3BMelissa%2C+S%3BDahdah%2C+M%3BBui%2C+M%3BWager%2C+J%3BSpina%2C+L&rft.aulast=Poole&rft.aufirst=J&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Influence of alternative thresholds for initiating HIV treatment on quality-adjusted life expectancy: a decision model. AN - 70273391; 18252681 AB - The optimal threshold for initiating HIV treatment is unclear. To compare different thresholds for initiating HIV treatment. A validated computer simulation was used to weigh important harms from earlier initiation of antiretroviral therapy (toxicity, side effects, and resistance accumulation) against important benefits (decreased HIV-related mortality). Veterans Aging Cohort Study (5742 HIV-infected patients and 11 484 matched uninfected controls) and published reports. Individuals with newly diagnosed chronic HIV infection and varying viral loads (10,000, 30,000, 100,000, and 300,000 copies/mL) and ages (30, 40, and 50 years). Unlimited. Societal. Alternative thresholds for initiating antiretroviral therapy (CD4 counts of 200, 350, and 500 cells/mm3). Life-years and quality-adjusted life-years (QALYs). Although the simulation was biased against earlier treatment initiation because it used an upper-bound assumption for therapy-related toxicity, earlier treatment increased life expectancy and QALYs at age 30 years regardless of viral load (life expectancies with CD4 initiation thresholds of 500, 350, and 200 cells/mm3 were 18.2 years, 17.6 years, and 17.2 years, respectively, for a viral load of 10,000 copies/mL and 17.3 years, 15.9 years, and 14.5 years, respectively, for a viral load of 300,000 copies/mL), and increased life expectancies at age 40 years if viral loads were greater than 30 000 copies/mL (life expectancies were 12.5 years, 12.0 years, and 11.4 years, respectively, for a viral load of 300,000 copies/mL). Findings favoring early treatment were generally robust. Results favoring later treatment may not be valid. The findings may not be generalizable to women. This simulation suggests that earlier initiation of combination antiretroviral therapy is often favored compared with current recommendations. JF - Annals of internal medicine AU - Braithwaite, R Scott AU - Roberts, Mark S AU - Chang, Chung Chou H AU - Goetz, Matthew Bidwell AU - Gibert, Cynthia L AU - Rodriguez-Barradas, Maria C AU - Shechter, Steven AU - Schaefer, Andrew AU - Nucifora, Kimberly AU - Koppenhaver, Robert AU - Justice, Amy C AD - Yale University and Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, USA. Ronald.Braithwaite@va.gov Y1 - 2008/02/05/ PY - 2008 DA - 2008 Feb 05 SP - 178 EP - 185 VL - 148 IS - 3 KW - Anti-HIV Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Sensitivity and Specificity KW - Drug Administration Schedule KW - Computer Simulation KW - Humans KW - Disease Progression KW - CD4 Lymphocyte Count KW - HIV -- genetics KW - Viral Load KW - Drug Therapy, Combination KW - Adult KW - Mutation KW - Time Factors KW - Decision Support Techniques KW - Quality-Adjusted Life Years KW - HIV Infections -- virology KW - HIV Infections -- drug therapy KW - Life Expectancy KW - Anti-HIV Agents -- adverse effects KW - Anti-HIV Agents -- administration & dosage KW - HIV Infections -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70273391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Influence+of+alternative+thresholds+for+initiating+HIV+treatment+on+quality-adjusted+life+expectancy%3A+a+decision+model.&rft.au=Braithwaite%2C+R+Scott%3BRoberts%2C+Mark+S%3BChang%2C+Chung+Chou+H%3BGoetz%2C+Matthew+Bidwell%3BGibert%2C+Cynthia+L%3BRodriguez-Barradas%2C+Maria+C%3BShechter%2C+Steven%3BSchaefer%2C+Andrew%3BNucifora%2C+Kimberly%3BKoppenhaver%2C+Robert%3BJustice%2C+Amy+C&rft.aulast=Braithwaite&rft.aufirst=R&rft.date=2008-02-05&rft.volume=148&rft.issue=3&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-20 N1 - Date created - 2008-02-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2003 Nov 20;349(21):1993-2003 [14627784] AIDS. 2003 Sep 5;17(13):1863-9 [12960818] Ann Intern Med. 2003 Apr 15;138(8):680-1 [12693893] Ann Intern Med. 2003 Apr 15;138(8):620-6 [12693883] J Acquir Immune Defic Syndr. 2003 Mar 1;32(3):259-67 [12626885] Lancet. 2002 Nov 30;360(9347):1747-8 [12480430] Arch Intern Med. 2002 Nov 25;162(21):2478-86 [12437408] JAMA. 2001 Nov 28;286(20):2568-77 [11722271] Lancet. 2002 Jul 13;360(9327):119-29 [12126821] J Infect Dis. 2003 Dec 1;188(11):1659-65 [14639536] AIDS. 2000 Sep 8;14(13):1921-33 [10997396] AIDS. 2000 Jun 16;14(9):1203-10 [10894285] Med Care. 2000 Jun;38(6):583-637 [10843310] JAMA. 2000 Jan 5;283(1):74-80 [10632283] AIDS. 2002 Jul 5;16(10):1371-81 [12131214] J Acquir Immune Defic Syndr. 2002 Sep 1;31(1):27-37 [12352147] Lancet. 2004 Jul 3-9;364(9428):51-62 [15234856] N Engl J Med. 1995 Aug 17;333(7):450-1 [7616996] J Infect Dis. 2004 Dec 1;190(11):1947-56 [15529259] Clin Infect Dis. 2004 Dec 1;39(11):1699-704 [15578373] N Engl J Med. 2005 Feb 10;352(6):570-85 [15703422] Am J Med. 2005 Aug;118(8):890-8 [16084183] Med Care. 2006 Aug;44(8 Suppl 2):S13-24 [16849964] Med Care. 2006 Aug;44(8 Suppl 2):S25-30 [16849965] Med Care. 2006 Nov;44(11):990-7 [17063130] N Engl J Med. 2006 Nov 30;355(22):2283-96 [17135583] Value Health. 2007 May-Jun;10(3):204-13 [17532813] Value Health. 2008 Sep-Oct;11(5):975-9 [18225989] J Antimicrob Chemother. 2006 Nov;58(5):1036-43 [17023498] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of carcinogen-induced premalignant oral lesions in a dendritic cell-based vaccine to stimulate immune reactivity against both premalignant oral lesions and oral cancer. AN - 70726570; 18481384 AB - Select groups of premalignant oral lesions carry a high risk of development of secondary premalignant lesions and oral squamous cell carcinoma (OSCC). The goal of the present study was to determine the feasibility of using premalignant lesion-pulsed dendritic cells as a treatment option to prevent development of secondary lesions and development of OSCC. Mice that were treated with the carcinogen 4-nitroquinoline-1-oxide (4NQO) developed premalignant oral lesions and, subsequently, OSCC. Immunohistochemical analyses showed that these 4NQO-induced lesions and OSCC both overexpressed the tumor antigens epidermal growth factor receptor, RAGE and, to a lesser extent, MUC1. Because there was shared overexpression of tumor antigens on premalignant oral lesions and OSCC, dendritic cells pulsed with lysates of 4NQO-induced premalignant lesion cells were tested in vitro and in vivo for their capacity to stimulate T-cell reactivity to premalignant lesion cells and to OSCC. Spleen cells that were sensitized during coculture or in vivo with premalignant lesion-pulsed dendritic cells were cytolytic toward both premalignant lesion cells and OSCC, and secreted increased levels of interferon -gamma in response to challenge with premalignant lesion cells or OSCC as compared with spleen cells that were sensitized with keratinocyte-pulsed dendritic cells. Levels of CD8+ Tcells and interferon-gamma release were also increased in lesions of mice that were vaccinated with premalignant lesion-pulsed dendritic cells. The mice that were vaccinated against premalignant lesions were also more resistant to OSCC challenge. These studies show the feasibility of using premalignant oral lesions to stimulate immune reactivity against both premalignant oral lesions and JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Young, M Rita I AD - Research Service, Ralph H. Johnson VA Medical Center, Charleston, SC 29401-5799, USA. rita.young@med.va.gov PY - 2008 SP - 148 EP - 156 VL - 31 IS - 2 SN - 1524-9557, 1524-9557 KW - 4-nitroquinolone-1-oxide KW - 0 KW - Antigens, Neoplasm KW - Cancer Vaccines KW - Quinolones KW - 4-Nitroquinoline-1-oxide KW - 56-57-5 KW - Interferon-gamma KW - 82115-62-6 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Animals KW - Tongue Neoplasms -- chemically induced KW - Receptor, Epidermal Growth Factor -- metabolism KW - Spleen -- cytology KW - CD8-Positive T-Lymphocytes -- metabolism KW - Tongue Neoplasms -- immunology KW - CD4-Positive T-Lymphocytes -- immunology KW - Mice KW - Tongue Neoplasms -- therapy KW - Cytotoxicity, Immunologic -- immunology KW - 4-Nitroquinoline-1-oxide -- pharmacology KW - CD4-Positive T-Lymphocytes -- metabolism KW - CD8-Positive T-Lymphocytes -- immunology KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Interferon-gamma -- metabolism KW - Spleen -- immunology KW - Antigens, Neoplasm -- immunology KW - Killer Cells, Natural -- metabolism KW - Female KW - Killer Cells, Natural -- immunology KW - Quinolones -- pharmacology KW - Mouth Neoplasms -- chemically induced KW - Dendritic Cells -- immunology KW - Carcinoma, Squamous Cell -- immunology KW - Cancer Vaccines -- immunology KW - Mouth Neoplasms -- immunology KW - Precancerous Conditions -- therapy KW - Precancerous Conditions -- chemically induced KW - Mouth Neoplasms -- therapy KW - Cancer Vaccines -- therapeutic use KW - Carcinoma, Squamous Cell -- chemically induced KW - Dendritic Cells -- transplantation KW - Precancerous Conditions -- immunology KW - Carcinoma, Squamous Cell -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70726570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Use+of+carcinogen-induced+premalignant+oral+lesions+in+a+dendritic+cell-based+vaccine+to+stimulate+immune+reactivity+against+both+premalignant+oral+lesions+and+oral+cancer.&rft.au=Young%2C+M+Rita+I&rft.aulast=Young&rft.aufirst=M+Rita&rft.date=2008-02-01&rft.volume=31&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/10.1097%2FCJI.0b013e31815bdbf5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-12 N1 - Date created - 2008-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CJI.0b013e31815bdbf5 ER - TY - JOUR T1 - Practical management of cutaneous reactions to the methylphenidate transdermal system: recommendations from a dermatology expert panel consensus meeting. AN - 70407638; 18343271 AB - Psychostimulants remain the most-used medications for attention-deficit/hyperactivity disorder (ADHD). The methylphenidate transdermal system (MTS) is the first stimulant patch dosage formulation to be approved by the US Food and Drug Administration for the treatment of the symptoms of ADHD in children aged 6 to 12 years. The MTS patch is approved to be applied once daily to the hip and worn for 9 hours. While cutaneous reactions may occur with any formulation of medication, they are more likely with transdermal administration. The purpose of this commentary was to describe the types of cutaneous reactions that have been reported with transdermal systems in general, review the cutaneous adverse events seen in clinical trials with the MTS specifically, and provide practical management suggestions for prevention and treatment of these potential cutaneous reactions. In September 2007, a group of child psychiatrists, pediatricians, developmental pediatricians, and pediatric neurologists who treat ADHD and have had experience in their practices with MTS convened to discuss cutaneous reactions in relation to its use. Information collected from this meeting and from the clinical trials database of the sponsor was reviewed by a panel of 3 dermatologic clinical experts in contact dermatitis and 1 pediatric dermatologist. The panel's recommendations form the basis for this report. Mild to moderate erythema is a common cutaneous effect with MTS use, and is generally not a cause for discontinuation if seen in isolation. Irritant contact dermatitis is relatively common and can be reduced and treated by alternating patch application sites, moisturizing, gentle skin care, and application of topical corticosteroids at the previous patch sites if needed. Allergic contact dermatitis (ACD) and allergic contact urticaria are rare when MTS is worn as directed in the prescribing information. MTS should be discontinued if ACD is suspected. JF - Clinical therapeutics AU - Warshaw, Erin M AU - Paller, Amy S AU - Fowler, Joseph F AU - Zirwas, Matthew J AD - Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA. erin.warshaw@va.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 326 EP - 337 VL - 30 IS - 2 KW - Central Nervous System Stimulants KW - 0 KW - Dosage Forms KW - Methylphenidate KW - 207ZZ9QZ49 KW - Index Medicus KW - Administration, Cutaneous KW - Humans KW - Urticaria -- chemically induced KW - Child KW - Dermatitis, Contact -- etiology KW - Urticaria -- therapy KW - Erythema -- chemically induced KW - Dermatitis, Allergic Contact -- etiology KW - Dermatitis, Contact -- therapy KW - Dermatitis, Allergic Contact -- therapy KW - Practice Guidelines as Topic KW - Consensus Development Conferences as Topic KW - Erythema -- therapy KW - Skin Diseases -- therapy KW - Methylphenidate -- administration & dosage KW - Methylphenidate -- adverse effects KW - Central Nervous System Stimulants -- adverse effects KW - Central Nervous System Stimulants -- administration & dosage KW - Skin Diseases -- chemically induced KW - Attention Deficit Disorder with Hyperactivity -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70407638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+therapeutics&rft.atitle=Practical+management+of+cutaneous+reactions+to+the+methylphenidate+transdermal+system%3A+recommendations+from+a+dermatology+expert+panel+consensus+meeting.&rft.au=Warshaw%2C+Erin+M%3BPaller%2C+Amy+S%3BFowler%2C+Joseph+F%3BZirwas%2C+Matthew+J&rft.aulast=Warshaw&rft.aufirst=Erin&rft.date=2008-02-01&rft.volume=30&rft.issue=2&rft.spage=326&rft.isbn=&rft.btitle=&rft.title=Clinical+therapeutics&rft.issn=1879-114X&rft_id=info:doi/10.1016%2Fj.clinthera.2008.01.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-08 N1 - Date created - 2008-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.clinthera.2008.01.022 ER - TY - JOUR T1 - Pharmacologic management of Alzheimer disease. AN - 70390903; 18330411 AB - Although the diagnosis of AD can be devastating, treatment options exist that can slow the disease's progression and allow patients to continue performing ADLs, thereby improving the quality of life for both patient and caregiver. Research is ongoing, and it is estimated by the Alzheimer's Association that finding a treatment that could delay onset by only 5 years could reduce the number of individuals with AD by nearly 50% over the next 50 years (Alzheimer's Association, 2007). Although pharmacotherapy is not yet a cure, it does remain an important part of a total approach to caring for patients and families affected by AD. JF - The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses AU - Downey, Deborah AD - Cleveland VA Medical Center, Cleveland, OH, USA. deborah.downey@va.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 55 EP - 59 VL - 40 IS - 1 SN - 0888-0395, 0888-0395 KW - Cholinesterase Inhibitors KW - 0 KW - Indans KW - Nootropic Agents KW - Phenylcarbamates KW - Piperidines KW - Galantamine KW - 0D3Q044KCA KW - N-Methylaspartate KW - 6384-92-5 KW - donepezil KW - 8SSC91326P KW - Rivastigmine KW - PKI06M3IW0 KW - Memantine KW - W8O17SJF3T KW - Index Medicus KW - Nursing KW - Indans -- therapeutic use KW - Memantine -- therapeutic use KW - Humans KW - Phenylcarbamates -- therapeutic use KW - Phenylcarbamates -- adverse effects KW - Phenylcarbamates -- administration & dosage KW - Indans -- administration & dosage KW - Memantine -- adverse effects KW - Piperidines -- adverse effects KW - Galantamine -- therapeutic use KW - Indans -- adverse effects KW - Drug Therapy, Combination KW - Galantamine -- adverse effects KW - Piperidines -- therapeutic use KW - Memantine -- administration & dosage KW - Galantamine -- administration & dosage KW - Piperidines -- administration & dosage KW - Cholinesterase Inhibitors -- administration & dosage KW - Cholinesterase Inhibitors -- adverse effects KW - Nootropic Agents -- administration & dosage KW - Cholinesterase Inhibitors -- therapeutic use KW - Alzheimer Disease -- physiopathology KW - Alzheimer Disease -- drug therapy KW - N-Methylaspartate -- antagonists & inhibitors KW - Nootropic Agents -- therapeutic use KW - Nootropic Agents -- adverse effects KW - Alzheimer Disease -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70390903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.atitle=Pharmacologic+management+of+Alzheimer+disease.&rft.au=Downey%2C+Deborah&rft.aulast=Downey&rft.aufirst=Deborah&rft.date=2008-02-01&rft.volume=40&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.issn=08880395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-29 N1 - Date created - 2008-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The internalizing and externalizing structure of psychiatric comorbidity in combat veterans. AN - 70362892; 18302181 AB - This study examined the latent structure of psychiatric disorders in a sample with a high prevalence of PTSD. A series of confirmatory factor analyses tested competing models for the covariation between Structured Clinical Interview for DSM-III-R diagnoses among 1,325 Vietnam veterans. The best-fitting solution was a 3-factor model that included two correlated internalizing factors: anxious-misery, defined by PTSD and major depression, and fear, defined by panic disorder/agoraphobia and obsessive-compulsive disorder. The third factor, externalizing, was defined by antisocial personality disorder, alcohol abuse/dependence, and drug abuse/dependence. Both substance-related disorders also showed significant, albeit smaller, cross-loadings on the anxious-misery factor. These findings shed new light on the structure of psychiatric comorbidity in a treatment-seeking sample characterized by high rates of PTSD. JF - Journal of traumatic stress AU - Miller, Mark W AU - Fogler, Jason M AU - Wolf, Erika J AU - Kaloupek, Danny G AU - Keane, Terence M AD - National Center for PTSD, VA Boston Healthcare System, Boston, MA 02130, USA. mark.miller5@va.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 58 EP - 65 VL - 21 IS - 1 SN - 0894-9867, 0894-9867 KW - Index Medicus KW - Agoraphobia -- diagnosis KW - Obsessive-Compulsive Disorder -- diagnosis KW - Alcoholism -- diagnosis KW - Fear KW - Humans KW - Personality Disorders -- psychology KW - Alcoholism -- psychology KW - Personality Disorders -- epidemiology KW - Alcoholism -- epidemiology KW - Obsessive-Compulsive Disorder -- psychology KW - Adult KW - Agoraphobia -- epidemiology KW - Anxiety Disorders -- epidemiology KW - Adolescent KW - Severity of Illness Index KW - Depressive Disorder, Major -- diagnosis KW - Anxiety Disorders -- psychology KW - Anxiety Disorders -- diagnosis KW - Depressive Disorder, Major -- epidemiology KW - Agoraphobia -- psychology KW - Personality Disorders -- diagnosis KW - Depressive Disorder, Major -- psychology KW - Obsessive-Compulsive Disorder -- epidemiology KW - Patient Acceptance of Health Care -- statistics & numerical data KW - Middle Aged KW - Diagnostic and Statistical Manual of Mental Disorders KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Veterans -- statistics & numerical data KW - Stress Disorders, Post-Traumatic -- psychology KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Vietnam Conflict KW - Veterans -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70362892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+traumatic+stress&rft.atitle=The+internalizing+and+externalizing+structure+of+psychiatric+comorbidity+in+combat+veterans.&rft.au=Miller%2C+Mark+W%3BFogler%2C+Jason+M%3BWolf%2C+Erika+J%3BKaloupek%2C+Danny+G%3BKeane%2C+Terence+M&rft.aulast=Miller&rft.aufirst=Mark&rft.date=2008-02-01&rft.volume=21&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Journal+of+traumatic+stress&rft.issn=08949867&rft_id=info:doi/10.1002%2Fjts.20303 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-25 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Depress Anxiety. 2002;15(4):168-71 [12112721] J Clin Psychiatry. 2000;61 Suppl 5:4-12; discussion 13-4 [10761674] Drug Alcohol Depend. 2000 Dec 22;61(1):95-102 [11064187] Biol Psychiatry. 2000 Nov 1;48(9):902-9 [11074228] Psychol Assess. 2003 Jun;15(2):205-15 [12847781] Twin Res. 2003 Jun;6(3):218-26 [12855071] J Abnorm Psychol. 2003 Aug;112(3):437-47 [12943022] Arch Gen Psychiatry. 2003 Sep;60(9):929-37 [12963675] J Nerv Ment Dis. 2003 Aug;191(8):531-7 [12972856] Psychol Rev. 2004 Jan;111(1):33-51 [14756584] Psychol Bull. 1978 Nov;85(6):1275-1301 [366649] Annu Rev Psychol. 1984;35:227-56 [6367624] Arch Gen Psychiatry. 1991 Mar;48(3):216-22 [1996917] Arch Gen Psychiatry. 1993 Sep;50(9):690-8 [8357294] Arch Gen Psychiatry. 1994 Jan;51(1):8-19 [8279933] Psychol Med. 1994 Feb;24(1):69-80 [8208896] J Clin Psychol. 1994 Jul;50(4):502-15 [7983198] Arch Gen Psychiatry. 1995 Dec;52(12):1048-60 [7492257] Psychol Bull. 1996 Jul;120(1):83-112 [8711018] Drug Alcohol Depend. 1996 Dec 2;43(1-2):49-55 [8957142] J Abnorm Psychol. 1998 May;107(2):179-92 [9604548] J Abnorm Psychol. 1998 May;107(2):216-27 [9604551] J Consult Clin Psychol. 1998 Dec;66(6):914-23 [9874904] Arch Gen Psychiatry. 1999 Oct;56(10):921-6 [10530634] J Abnorm Psychol. 2004 Nov;113(4):636-45 [15535795] Arch Gen Psychiatry. 2005 Jun;62(6):617-27 [15939839] Arch Gen Psychiatry. 2005 Oct;62(10):1097-106 [16203955] Arch Gen Psychiatry. 2005 Nov;62(11):1258-65 [16275813] J Abnorm Psychol. 2005 Nov;114(4):522-36 [16351375] J Abnorm Psychol. 2006 May;115(2):369-79 [16737401] Psychol Med. 2006 Nov;36(11):1593-600 [16882356] Behav Ther. 2007 Mar;38(1):58-71 [17292695] Arch Gen Psychiatry. 2001 Jun;58(6):597-603 [11386990] Psychiatry Res. 2001 Sep 20;103(2-3):133-45 [11549402] J Abnorm Psychol. 2001 Nov;110(4):585-99 [11727948] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jts.20303 ER - TY - JOUR T1 - Deployment stressors and posttraumatic stress symptomatology: comparing active duty and National Guard/Reserve personnel from Gulf War I. AN - 70357407; 18302185 AB - The increased use of National Guard and Reserve (NG/R) military personnel in current conflicts raises the question of whether deployment experiences and their associations with posttraumatic stress symptomatology differ for active duty and NG/R military personnel. To date, very few studies are available on this topic. Moreover, it is unclear whether the impact of military status differs for women and men. We addressed these research issues in a sample of 311 female and male Gulf War I veterans. Several differences were observed in deployment stressor exposures and results based on differential associations generally suggested more negative impacts of deployment experiences for active duty women and NG/R men. The potential role of unit cohesion in explaining these findings is discussed. JF - Journal of traumatic stress AU - Vogt, Dawne S AU - Samper, Rita E AU - King, Daniel W AU - King, Lynda A AU - Martin, James A AD - Women's Health Sciences Division, National Center for PTSD, Boston, MA 02130, USA. Dawne.Vogt@va.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 66 EP - 74 VL - 21 IS - 1 SN - 0894-9867, 0894-9867 KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Female KW - Prevalence KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Stress Disorders, Post-Traumatic -- psychology KW - Life Change Events KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Military Personnel -- psychology KW - Persian Gulf Syndrome -- epidemiology KW - Persian Gulf Syndrome -- diagnosis KW - Military Personnel -- statistics & numerical data KW - Persian Gulf Syndrome -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70357407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+traumatic+stress&rft.atitle=Deployment+stressors+and+posttraumatic+stress+symptomatology%3A+comparing+active+duty+and+National+Guard%2FReserve+personnel+from+Gulf+War+I.&rft.au=Vogt%2C+Dawne+S%3BSamper%2C+Rita+E%3BKing%2C+Daniel+W%3BKing%2C+Lynda+A%3BMartin%2C+James+A&rft.aulast=Vogt&rft.aufirst=Dawne&rft.date=2008-02-01&rft.volume=21&rft.issue=1&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Journal+of+traumatic+stress&rft.issn=08949867&rft_id=info:doi/10.1002%2Fjts.20306 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-25 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jts.20306 ER - TY - JOUR T1 - Clinical practice algorithms: medication management to reduce fall risk in the elderly--Part 3, benzodiazepines, cardiovascular agents, and antidepressants. AN - 70300198; 18271759 JF - Journal of the American Academy of Nurse Practitioners AU - Bulat, Tatjana AU - Castle, Steven Charles AU - Rutledge, Michelle AU - Quigley, Patricia AD - VISN 8 Patient Safety Center, Tampa, Florida 33612, USA. tatjana.bulat@va.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 55 EP - 62 VL - 20 IS - 2 SN - 1041-2972, 1041-2972 KW - Anti-Anxiety Agents KW - 0 KW - Antidepressive Agents KW - Cardiovascular Agents KW - Benzodiazepines KW - 12794-10-4 KW - Nursing KW - Drug Monitoring -- methods KW - Drug Administration Schedule KW - Humans KW - Aged KW - Patient Selection KW - Geriatric Assessment KW - Patient Education as Topic KW - Nursing Assessment KW - Decision Trees KW - Drug Monitoring -- nursing KW - Practice Guidelines as Topic KW - Nurse Practitioners KW - Geriatric Nursing KW - Safety Management -- organization & administration KW - Benzodiazepines -- therapeutic use KW - Cardiovascular Agents -- therapeutic use KW - Benzodiazepines -- adverse effects KW - Anti-Anxiety Agents -- therapeutic use KW - Anti-Anxiety Agents -- adverse effects KW - Algorithms KW - Accidental Falls -- prevention & control KW - Antidepressive Agents -- therapeutic use KW - Antidepressive Agents -- adverse effects KW - Cardiovascular Agents -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70300198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Nurse+Practitioners&rft.atitle=Clinical+practice+algorithms%3A+medication+management+to+reduce+fall+risk+in+the+elderly--Part+3%2C+benzodiazepines%2C+cardiovascular+agents%2C+and+antidepressants.&rft.au=Bulat%2C+Tatjana%3BCastle%2C+Steven+Charles%3BRutledge%2C+Michelle%3BQuigley%2C+Patricia&rft.aulast=Bulat&rft.aufirst=Tatjana&rft.date=2008-02-01&rft.volume=20&rft.issue=2&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Nurse+Practitioners&rft.issn=10412972&rft_id=info:doi/10.1111%2Fj.1745-7599.2007.00285.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-22 N1 - Date created - 2008-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1745-7599.2007.00285.x ER - TY - JOUR T1 - Treating geriatric depression in primary care. AN - 70293310; 18269894 AB - Depression, a significant problem among older adults, is most commonly reported in the primary care setting. To offer the treatments for depression preferred by many older adults, clinical providers and researchers have called for the creation of integrative psychosocial care options in primary care, using mental health providers working in collaboration with medical providers. In this article, we examine the empirical status of integrating treatment for depression in older adults in the primary care setting by summarizing the current models of integrated care and latest research developments. We discuss the strengths and limitations of the current integration models and offer recommendations for expanding work in this important area. JF - Current psychiatry reports AU - Skultety, Karyn M AU - Rodriguez, Rachel L AD - Geriatric Research Education and Clinical Center, VA Palo Alto Healthcare System, 3801 Miranda Avenue (182B), Palo Alto, CA 94304, USA. Karyn.Skultety@va.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 44 EP - 50 VL - 10 IS - 1 KW - Antidepressive Agents KW - 0 KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Cooperative Behavior KW - Psychotherapy KW - Combined Modality Therapy KW - Humans KW - Aged KW - Case Management KW - Depressive Disorder, Major -- diagnosis KW - Depressive Disorder, Major -- drug therapy KW - Patient Care Team KW - Depressive Disorder, Major -- psychology KW - Antidepressive Agents -- therapeutic use KW - Primary Health Care KW - Antidepressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70293310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+psychiatry+reports&rft.atitle=Treating+geriatric+depression+in+primary+care.&rft.au=Skultety%2C+Karyn+M%3BRodriguez%2C+Rachel+L&rft.aulast=Skultety&rft.aufirst=Karyn&rft.date=2008-02-01&rft.volume=10&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Current+psychiatry+reports&rft.issn=1535-1645&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-07 N1 - Date created - 2008-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site. AN - 70269926; 17901997 AB - N-methyl-D-aspartate receptor (NMDAR) hypo-function theory of schizophrenia proposes that impairment in NMDAR function be associated with the pathophysiology of schizophrenia and suggests that enhancement of the receptor function may produce efficacy for schizophrenia. Consistent with this theory, for the last decade, clinical trials have demonstrated that the enhancement of NMDAR function by potentiating the glycine site of the receptor is efficacious in the treatment of schizophrenia. Full agonists of the glycine site, glycine and D-serine and a glycine transporter-1 inhibitor, sarcosine, added to antipsychotic drugs, have been shown to be effective in the treatment of negative symptoms and possibly cognitive symptoms without significantly affecting the positive symptoms of schizophrenia. A partial agonist of the glycine site, D-cycloserine, added to antipsychotic drugs, can be effective for the negative symptoms at the therapeutic doses. However, these drugs have not shown clinical efficacy when added to clozapine, suggesting that the interactions of clozapine and the glycine site potentiators may be different from those of other antipsychotic drugs and the potentiators. This article suggests that the glycine site potentiators may produce efficacy for negative and cognitive symptoms by blocking apoptosis-like neuropathological processes in patients with chronic schizophrenia and thereby can deter progressive deterioration of the disorder. This article proposes a polypharmacy of glycine site potentiators augmented with antipsychotic drugs to control positive and negative symptoms in a synergistic manner and block deterioration in schizophrenia. Since the NMDAR complex consists of multiple sites modulating receptor functions, the efficacy of glycine site potentiators for schizophrenia suggests the possibility that manipulation of other modulating sites of the NMDAR can also be efficacious in the treatment of schizophrenia. JF - European archives of psychiatry and clinical neuroscience AU - Shim, Seong S AU - Hammonds, Michael D AU - Kee, Baik S AD - Case Western Reserve University School of Medicine, Department of Psychiatry, Cleveland VA Medical Center Psychiatric Services 116 A(W), Cleveland, Ohio 44106, USA. seong.shim@med.va.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 16 EP - 27 VL - 258 IS - 1 SN - 0940-1334, 0940-1334 KW - Acetamides KW - 0 KW - Antipsychotic Agents KW - Dopamine Agents KW - Glycine Agents KW - Glycine Plasma Membrane Transport Proteins KW - Monoamine Oxidase Inhibitors KW - Receptors, Glycine KW - Receptors, N-Methyl-D-Aspartate KW - milacemide KW - 0HXT24RECU KW - Serine KW - 452VLY9402 KW - Cycloserine KW - 95IK5KI84Z KW - Clozapine KW - J60AR2IKIC KW - Alanine KW - OF5P57N2ZX KW - Glycine KW - TE7660XO1C KW - Sarcosine KW - Z711V88R5F KW - Index Medicus KW - Glycine Agents -- therapeutic use KW - Sarcosine -- therapeutic use KW - Serine -- therapeutic use KW - Cycloserine -- therapeutic use KW - Humans KW - Glycine Plasma Membrane Transport Proteins -- antagonists & inhibitors KW - Alanine -- therapeutic use KW - Cognition -- physiology KW - Drug Therapy, Combination KW - Dopamine Agents -- therapeutic use KW - Clozapine -- therapeutic use KW - Glycine -- therapeutic use KW - Schizophrenic Psychology KW - Acetamides -- therapeutic use KW - Drug Synergism KW - Monoamine Oxidase Inhibitors -- therapeutic use KW - Receptors, N-Methyl-D-Aspartate -- physiology KW - Receptors, N-Methyl-D-Aspartate -- agonists KW - Receptors, Glycine -- physiology KW - Antipsychotic Agents -- pharmacology KW - Schizophrenia -- drug therapy KW - Receptors, Glycine -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70269926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+archives+of+psychiatry+and+clinical+neuroscience&rft.atitle=Potentiation+of+the+NMDA+receptor+in+the+treatment+of+schizophrenia%3A+focused+on+the+glycine+site.&rft.au=Shim%2C+Seong+S%3BHammonds%2C+Michael+D%3BKee%2C+Baik+S&rft.aulast=Shim&rft.aufirst=Seong&rft.date=2008-02-01&rft.volume=258&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=European+archives+of+psychiatry+and+clinical+neuroscience&rft.issn=09401334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-31 N1 - Date created - 2008-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effective interventions and implementation strategies to reduce adverse drug events in the Veterans Affairs (VA) system. AN - 70257351; 18245218 AB - Adverse drug events (ADEs) account for considerable patient morbidity and mortality as well as legal, operational and patient care costs. In Veterans Affairs (VA) hospitals in the USA, all serious adverse events and "potential" adverse events are reviewed using root cause analysis (RCA). This study characterised RCA reports associated with ADEs to determine what actions VA RCA teams took to reduce the number or severity of ADEs, and to evaluate which actions were effective in doing so. Every medication-related RCA submitted to the VA National Center for Patient Safety in the fiscal year 2004 (143 reports), and one medication-related aggregated RCA from each facility (111 reports covering 4834 ADEs) were reviewed and coded. Facilities were interviewed about specifics of their reports and the results of their interventions. The commonest classes of medication for which ADEs were reported were narcotics, chemotherapy, and diabetic and cardiovascular medications. The most common types of ADE were "wrong dose", "wrong medication", "failed to give medication", and "wrong patient". 993 actions were taken to address these ADEs, the majority (75.7%) of which were reported to be fully implemented. Improvements in equipment and improving clinical care at the bedside were associated with reports of improved outcomes (p = 0.018, and p = 0.017 respectively), and training and education were negatively correlated with reports of improved outcome (p = 0.005). Improving the process of medication order entry through the use of alerts or forcing functions was positively correlated with reports of improved outcomes (p = 0.022). Leadership support and involving staff were associated with higher implementation rates (p = 0.001 and p = 0.010, respectively). Changes at the bedside and improvement in equipment and computers are effective at reducing ADEs. Well-organised tracking and support from leadership and staff were characteristics of facilities successful at improving outcomes. Training without action was associated with worse outcomes. JF - Quality & safety in health care AU - Mills, P D AU - Neily, J AU - Kinney, L M AU - Bagian, J AU - Weeks, W B AD - VA National Center for Patient Safety, White River Junction, Vermont 05009, USA. Peter.Mills@va.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 37 EP - 46 VL - 17 IS - 1 KW - Health administration KW - United States KW - Humans KW - Organizational Culture KW - Health Services Research KW - Outcome and Process Assessment (Health Care) KW - Health Plan Implementation KW - Drug Therapy, Computer-Assisted KW - Medication Errors -- prevention & control KW - Drug-Related Side Effects and Adverse Reactions KW - Total Quality Management KW - Medication Systems, Hospital -- standards KW - Medication Errors -- statistics & numerical data KW - Hospitals, Veterans -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70257351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quality+%26+safety+in+health+care&rft.atitle=Effective+interventions+and+implementation+strategies+to+reduce+adverse+drug+events+in+the+Veterans+Affairs+%28VA%29+system.&rft.au=Mills%2C+P+D%3BNeily%2C+J%3BKinney%2C+L+M%3BBagian%2C+J%3BWeeks%2C+W+B&rft.aulast=Mills&rft.aufirst=P&rft.date=2008-02-01&rft.volume=17&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Quality+%26+safety+in+health+care&rft.issn=1475-3901&rft_id=info:doi/10.1136%2Fqshc.2006.021816 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-28 N1 - Date created - 2008-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/qshc.2006.021816 ER - TY - JOUR T1 - Matching clients to psychosocial treatments: at the cusp of hope and evidence? AN - 70207083; 18199301 JF - Addiction (Abingdon, England) AU - Finney, John W AD - Center for Health Care Evaluation, VA Palo Alto HCS (152MPD), Menlo Park, CA 94025, USA. john.finney@va.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 239 EP - 240 VL - 103 IS - 2 SN - 0965-2140, 0965-2140 KW - Index Medicus KW - Humans KW - Treatment Outcome KW - United Kingdom KW - Alcoholism -- rehabilitation KW - Psychotherapy -- methods KW - Patient Selection KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70207083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Matching+clients+to+psychosocial+treatments%3A+at+the+cusp+of+hope+and+evidence%3F&rft.au=Finney%2C+John+W&rft.aulast=Finney&rft.aufirst=John&rft.date=2008-02-01&rft.volume=103&rft.issue=2&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.02117.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-10 N1 - Date created - 2008-01-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Addiction. 2008 Feb;103(2):228-38 [18070238] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1360-0443.2007.02117.x ER - TY - JOUR T1 - Effects of CDP-choline and the combination of CDP-choline and galantamine differ in an animal model of schizophrenia: development of a selective alpha7 nicotinic acetylcholine receptor agonist strategy. AN - 70159564; 17656074 AB - The regionally selective reduction of expression of the alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) in schizophrenia underlies impaired sensory inhibition, a possible endophenotype of the disorder. This ligand-gated ion channel receptor has been proposed as a pharmacotherapeutic target in schizophrenia. The current study examined the effect of CDP-choline alone and the combination of CDP-choline and galantamine, administered acutely and once-daily for five consecutive days, in an animal model of NMDA receptor hypofunction that is relevant to schizophrenia. The results support the allosteric modulatory influence of galantamine on CDP-choline; however, individual doses of CDP-choline and galantamine must be carefully titrated in order to achieve optimal levels of alpha7 nAChR "agonism" that may be necessary for the desired therapeutic effect. JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology AU - Deutsch, Stephen I AU - Rosse, Richard B AU - Schwartz, Barbara L AU - Schooler, Nina R AU - Gaskins, Brooke L AU - Long, Katrice D AU - Mastropaolo, John AD - Mental Health Service Line (116A), Department of Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, United States. Stephen.Deutsch@med.va.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 147 EP - 151 VL - 18 IS - 2 SN - 0924-977X, 0924-977X KW - Cholinesterase Inhibitors KW - 0 KW - Excitatory Amino Acid Antagonists KW - Nootropic Agents KW - Galantamine KW - 0D3Q044KCA KW - Cytidine Diphosphate Choline KW - 536BQ2JVC7 KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - Index Medicus KW - Drug Therapy, Combination KW - Behavior, Animal -- drug effects KW - Animals KW - Drug Interactions KW - Analysis of Variance KW - Disease Models, Animal KW - Mice KW - Male KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Dizocilpine Maleate -- pharmacology KW - Cytidine Diphosphate Choline -- therapeutic use KW - Cholinesterase Inhibitors -- therapeutic use KW - Schizophrenia -- drug therapy KW - Nootropic Agents -- therapeutic use KW - Galantamine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70159564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.atitle=Effects+of+CDP-choline+and+the+combination+of+CDP-choline+and+galantamine+differ+in+an+animal+model+of+schizophrenia%3A+development+of+a+selective+alpha7+nicotinic+acetylcholine+receptor+agonist+strategy.&rft.au=Deutsch%2C+Stephen+I%3BRosse%2C+Richard+B%3BSchwartz%2C+Barbara+L%3BSchooler%2C+Nina+R%3BGaskins%2C+Brooke+L%3BLong%2C+Katrice+D%3BMastropaolo%2C+John&rft.aulast=Deutsch&rft.aufirst=Stephen&rft.date=2008-02-01&rft.volume=18&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.issn=0924977X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-18 N1 - Date created - 2007-12-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Osteoporosis risk factor assessment increases the appropriate use of dual energy X-ray absorptiometry in men and reduces ethnic disparity. AN - 69134673; 18431089 AB - Male patients are frequently not tested for osteoporosis even in the presence of recognized risk factors for that disease. To evaluate if the assessment of risk factors for osteoporosis increases the utility of dual energy X-ray absorptiometry (DXA) in men over the age of 50 attending a rheumatology clinic. Men over 50 attending a rheumatology clinic completed a checklist of 10 risk factors for osteoporosis before seeing the physician. The physician reviewed the checklist and made a management decision. The checklists and medical records were reviewed for medical history and DXA results. Comparisons were made with DXA requests before the use of the checklist. Medical records of 183 men were reviewed, including 111 African Americans (AA) and 67 whites. Twenty-three percent of patients had rheumatoid arthritis (14% of AA, 37% of whites) and 27% of patients were on glucococorticoids. Before the use of the checklist, 14% of men had a DXA (6% of AA and 29% of whites) compared with 29% of patients (21% for AA and 42% for whites) after the checklist was instituted in the clinic. Sixty-three percent of AA with rheumatoid arthritis had DXA compared with 65% of whites. Thirteen patients had osteoporosis whereas 16 had osteopenia. The use of a check list of risk factors for osteoporosis may increase the appropriate use of DXA in male patients over the age of 50 at risk for osteoporosis. JF - Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases AU - Richards, J Steuart AU - Amdur, Richard L AU - Kerr, Gail S AD - Rheumatology Section 151 K, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA. john.richards@med.va.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 1 EP - 5 VL - 14 IS - 1 KW - Steroids KW - 0 KW - Index Medicus KW - Steroids -- adverse effects KW - Clinical Competence KW - Rheumatic Diseases -- complications KW - Humans KW - European Continental Ancestry Group KW - Aged KW - African Americans KW - Physicians KW - Middle Aged KW - Rheumatic Diseases -- drug therapy KW - Male KW - Outpatient Clinics, Hospital KW - Osteoporosis -- diagnosis KW - Critical Pathways KW - Bone Density KW - Absorptiometry, Photon KW - Osteoporosis -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69134673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+rheumatology+%3A+practical+reports+on+rheumatic+%26+musculoskeletal+diseases&rft.atitle=Osteoporosis+risk+factor+assessment+increases+the+appropriate+use+of+dual+energy+X-ray+absorptiometry+in+men+and+reduces+ethnic+disparity.&rft.au=Richards%2C+J+Steuart%3BAmdur%2C+Richard+L%3BKerr%2C+Gail+S&rft.aulast=Richards&rft.aufirst=J&rft.date=2008-02-01&rft.volume=14&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+rheumatology+%3A+practical+reports+on+rheumatic+%26+musculoskeletal+diseases&rft.issn=1536-7355&rft_id=info:doi/10.1097%2FRHU.0b013e31816356be LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-03 N1 - Date created - 2008-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/RHU.0b013e31816356be ER - TY - JOUR T1 - Prosthetics in the VA: Past, Present, and Future AN - 58773305; 2008-139050 AB - The war on terrorism has gone on for nearly seven years, with 4,000 deaths and 27,000 wounded, of which 15,000 have returned to duty after 72 hours. The seriously wounded recuperating in military hospitals have received a great deal of press and public attention. They also paint a vivid picture of the cost of war on America's military men and women. Where needed, prosthetic devices will be provided to these people for the rest of their lives by the Department of Veterans Affairs (VA). Adapted from the source document. JF - U.S. Naval Institute Proceedings AU - Downs, Frederick, Jr AD - Veterans Health Administration, Department of Veterans Affairs Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 56 EP - 61 PB - U.S. Naval Institute, Annapolis, MD VL - 134 IS - 2 SN - 0041-798X, 0041-798X KW - International relations - International peace and security KW - Military and defense policy - National defense KW - Health conditions and policy - Hospitals and other health care facilities KW - Military and defense policy - Military personnel and veterans KW - Hospitals, Veterans' KW - Counterterrorism KW - Service women KW - Disabled KW - Casualties KW - Service men KW - United States Veterans administration KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58773305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=U.S.+Naval+Institute+Proceedings&rft.atitle=Prosthetics+in+the+VA%3A+Past%2C+Present%2C+and+Future&rft.au=Downs%2C+Frederick%2C+Jr&rft.aulast=Downs&rft.aufirst=Frederick&rft.date=2008-02-01&rft.volume=134&rft.issue=2&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=U.S.+Naval+Institute+Proceedings&rft.issn=0041798X&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2008-06-04 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United States Veterans administration; Counterterrorism; Hospitals, Veterans'; Casualties; Service men; Service women; Disabled ER - TY - JOUR T1 - Negative Emotions, Pain, and Functioning AN - 57282256; 200917135 AB - We used linear structural equations (path model analysis) to examine associations among negative emotions, pain, and functioning in a large sample (N = 511) of veterans with chronic pain. We postulated and tested a model where pain and functioning affect negative emotions and where negative emotions affect pain and functioning. The findings confirm a strong relationship between negative emotions, pain, and functioning in our sample, particularly as the variable Pain Interference affects Depression. In a significant but weaker relationship, we also found that Anxiety has a direct effect on patients' perception of their Disability. Specifically, the data support a model where increased Pain Interference, Pain Severity, Depression and Anxiety all lead to increased Disability. Findings that Pain Interference and Depression appear to play a major role in the relationships between pain and negative emotions support the need for experimental studies to understand the causal impact of these variables on patient functioning. In the meantime, the findings suggest that Pain Interference, Depression, and Anxiety, in addition to Pain Severity, should all be targets of chronic pain treatment. [Copyright Elsevier B.V.] JF - Psychological Services AU - Tan, Gabriel AU - Jensen, Mark P AU - Thornby, John AU - Sloan, Paul A AD - Michael E. DeBakey VAMC tan.gabriel@med.va.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 26 EP - 35 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 5 IS - 1 SN - 1541-1559, 1541-1559 KW - pain negative emotions pain interference pain functioning KW - Negative emotions KW - Severity KW - Chronic pain KW - Disability KW - Interference KW - Anxiety-Depression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57282256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Negative+Emotions%2C+Pain%2C+and+Functioning&rft.au=Tan%2C+Gabriel%3BJensen%2C+Mark+P%3BThornby%2C+John%3BSloan%2C+Paul+A&rft.aulast=Tan&rft.aufirst=Gabriel&rft.date=2008-02-01&rft.volume=5&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2F1541-1559.5.1.26 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Chronic pain; Anxiety-Depression; Negative emotions; Interference; Severity; Disability DO - http://dx.doi.org/10.1037/1541-1559.5.1.26 ER - TY - JOUR T1 - Does Clinical Status Change in Anticipation of a PTSD Disability Examination? AN - 57281856; 200917027 AB - Although there has been considerable research on forensic aspects of disability evaluations for mental health claims, there has been little focus on the clinical impact of disability system participation. Using a prospective design, we examined whether disability system participation affected psychiatric symptom and disability levels in claimants filing for VA disability benefits on the basis of posttraumatic stress disorder (PTSD). Claimants had high levels of PTSD symptoms and disability at the time of claim initiation. Modest increases in illness severity were observed at the time of the disability examination. Factors associated with symptom change were income level and employment status. Negative expectations about the disability claims process were associated with severity of PTSD symptoms, but not with change in symptom levels over time. [Copyright Elsevier B.V.] JF - Psychological Services AU - Spoont, Michele R AU - Sayer, Nina A AU - Nelson, David B AU - Clothier, Barbara AU - Murdoch, Maureen AU - Nugent, Sean AD - Center for Chronic Disease Outcome Research, VA Medical Center, Minneapolis, Minnesota michele.spoont@med.va.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 49 EP - 59 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 5 IS - 1 SN - 1541-1559, 1541-1559 KW - PTSD disability evaluation symptoms expectancies KW - Symptoms KW - Severity KW - Posttraumatic stress disorder KW - Claimants KW - Disability KW - Anticipation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Does+Clinical+Status+Change+in+Anticipation+of+a+PTSD+Disability+Examination%3F&rft.au=Spoont%2C+Michele+R%3BSayer%2C+Nina+A%3BNelson%2C+David+B%3BClothier%2C+Barbara%3BMurdoch%2C+Maureen%3BNugent%2C+Sean&rft.aulast=Spoont&rft.aufirst=Michele&rft.date=2008-02-01&rft.volume=5&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2F1541-1559.5.1.49 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Disability; Posttraumatic stress disorder; Symptoms; Claimants; Severity; Anticipation DO - http://dx.doi.org/10.1037/1541-1559.5.1.49 ER - TY - JOUR T1 - Detection of deception with fMRI: Are we there yet? AN - 57245104; 200814392 AB - A decade of spectacular progress in functional magnetic resonance imaging (fMRI) technology and systems neuroscience research has so far yielded few changes in our daily lives. The dearth of clinical applications of this prolific and academically promising research tool began raising the eyebrows of the public and the research funding agencies. This may be one of the reasons for the enthusiasm and interest paid to the growing body of literature suggesting that blood oxygenation level-dependent (BOLD) fMRI of the brain could be sensitive to the differences between lie and truth. The word 'differences' is critical here since it refers to the often-ignored core concept of BOLD fMRI: it is only sensitive to differences between two brain states. Thus, available studies report using fMRI to discriminate between lie and truth or some other comparative state rather than to positively identify deception. This nuance is an example of the extent to which applied neuroscience research does not lend itself to the type of over-simplification that has plagued the interpretation of fMRI-based lie detection by the popular press and the increasingly vocal academic critics. As an early contributor to the modest stream of data on fMRI-based lie detection, I was asked by Dr Aldert Vrij to write a piece in favour of fMRI-based lie detection, to be contrasted with a piece by Dr Sean Spence presenting an opposite point of view (Spence, 2008). This seemingly straightforward task presented two hurdles: having to respond to the popular as well as scientific view of what lie detection with fMRI is and present a wholly positive view of evolving experimental data. Adapted from the source document. JF - Legal and Criminological Psychology AU - Langleben, Daniel D AD - Department of Psychiatry, University of Pennsylvania and the Veterans Administration Medical Center, Philadelphia, USA Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 1 EP - 9 PB - British Psychological Society, Leicester UK VL - 13 IS - 1 SN - 1355-3259, 1355-3259 KW - Attitudes KW - Deception KW - Functional magnetic resonance imaging KW - Neurosciences KW - Brain KW - Lie detection KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57245104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Legal+and+Criminological+Psychology&rft.atitle=Detection+of+deception+with+fMRI%3A+Are+we+there+yet%3F&rft.au=Langleben%2C+Daniel+D&rft.aulast=Langleben&rft.aufirst=Daniel&rft.date=2008-02-01&rft.volume=13&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Legal+and+Criminological+Psychology&rft.issn=13553259&rft_id=info:doi/10.1348%2F135532507X251641 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-27 N1 - Last updated - 2016-09-27 N1 - CODEN - LCPSFX N1 - SubjectsTermNotLitGenreText - Lie detection; Attitudes; Brain; Neurosciences; Functional magnetic resonance imaging; Deception DO - http://dx.doi.org/10.1348/135532507X251641 ER - TY - JOUR T1 - Macrolide and Clindamycin Resistance in Staphylococcus aureus Isolates and Antibiotic Use in a Veterans Affairs Medical Center AN - 21062043; 8585030 AB - A retrospective analysis of 13,946 Staphylococcus aureus isolates revealed a stable incidence of isolates that were resistant to both clindamycin and erythromycin, but a significantly increasing incidence of isolates that were susceptible to clindamycin and resistant to erythromycin during 1991-1995, 1996-2000, and 2001-2005. The use of macrolides and clindamycin also increased during 1996-2005. The incidence of S. aureus isolates with inducible clindamycin resistance increased steadily and significantly during the period from August 2004 through December 2005. JF - Infection Control and Hospital Epidemiology AU - Modak, Rohit AU - Ross, David AU - Kan, Virginia L AD - Infectious Diseases Section, Medical Service, Veterans Affairs Medical Center, Washington, DC., virginia.kan@va.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 180 EP - 182 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 29 IS - 2 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - Clindamycin KW - Antibiotics KW - Staphylococcus aureus KW - Erythromycin KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21062043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Macrolide+and+Clindamycin+Resistance+in+Staphylococcus+aureus+Isolates+and+Antibiotic+Use+in+a+Veterans+Affairs+Medical+Center&rft.au=Modak%2C+Rohit%3BRoss%2C+David%3BKan%2C+Virginia+L&rft.aulast=Modak&rft.aufirst=Rohit&rft.date=2008-02-01&rft.volume=29&rft.issue=2&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F526448 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Clindamycin; Antibiotics; Erythromycin; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1086/526448 ER - TY - JOUR T1 - Interferons Increase Cell Resistance to Staphylococcal Alpha-Toxin AN - 20530563; 8037490 AB - Many bacterial pathogens, including Staphylococcus aureus, use a variety of pore-forming toxins as important virulence factors. Staphylococcal alpha-toxin, a prototype beta -barrel pore-forming toxin, triggers the release of proinflammatory mediators and induces primarily necrotic death in susceptible cells. However, whether host factors released in response to staphylococcal infections may increase cell resistance to alpha-toxin is not known. Here we show that prior exposure to interferons (IFNs) prevents alpha-toxin-induced membrane permeabilization, the depletion of ATP, and cell death. Moreover, pretreatment with IFN- alpha decreases alpha-toxin-induced secretion of interleukin 1 beta (IL-1 beta ). IFN- alpha , IFN- beta , and IFN- gamma specifically protect cells from alpha-toxin, whereas tumor necrosis factor alpha (TNF- alpha ), IL-6, and IL-4 have no effects. Furthermore, we show that IFN- alpha -induced protection from alpha-toxin is not dependent on caspase-1 or mitogen-activated protein kinases, but requires protein synthesis and fatty acid synthase activity. Our results demonstrate that IFNs may increase cell resistance to staphylococcal alpha-toxin via the regulation of lipid metabolism and suggest that interferons play a protective role during staphylococcal infections. JF - Infection and Immunity AU - Yarovinsky, Timur O AU - Monick, Martha M AU - Husmann, Matthias AU - Hunninghake, Gary W AD - Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520. University of Iowa Carver College of Medicine, Veterans Administration Medical Center, Iowa City, Iowa 52242. Institute of Medical Microbiology and Hygiene, Johannes Gutenberg-University Mainz, Mainz, Germany Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 571 EP - 577 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 2 SN - 0019-9567, 0019-9567 KW - Toxicology Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - beta -Interferon KW - Interleukin 6 KW - gamma -Interferon KW - MAP kinase KW - Interleukin 4 KW - Protein biosynthesis KW - virulence factors KW - Interleukin 1 KW - ATP KW - Pathogens KW - Infection KW - Toxins KW - Fatty-acid synthase KW - Inflammation KW - Lipid metabolism KW - Interferon KW - Cell death KW - alpha -Interferon KW - Caspase-1 KW - Tumor necrosis factor- alpha KW - Staphylococcus aureus KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20530563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Interferons+Increase+Cell+Resistance+to+Staphylococcal+Alpha-Toxin&rft.au=Yarovinsky%2C+Timur+O%3BMonick%2C+Martha+M%3BHusmann%2C+Matthias%3BHunninghake%2C+Gary+W&rft.aulast=Yarovinsky&rft.aufirst=Timur&rft.date=2008-02-01&rft.volume=76&rft.issue=2&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; beta -Interferon; gamma -Interferon; Interleukin 4; MAP kinase; Protein biosynthesis; virulence factors; Interleukin 1; ATP; Pathogens; Infection; Toxins; Lipid metabolism; Inflammation; Fatty-acid synthase; Interferon; Cell death; alpha -Interferon; Caspase-1; Tumor necrosis factor- alpha; Staphylococcus aureus ER - TY - JOUR T1 - Importance of Bacterial Burden Among Methicillin-Resistant Staphylococcus aureus Carriers in a Long-Term Care Facility AN - 19608385; 8585023 AB - Objective. To evaluate the prevalence and transmission of methicillin- resistant Staphylococcus aureus (MRSA) nasal colonization, as well as risk factors associated with MRSA carriage, among residents of a long-term care facility (LTCF). Design. Prospective, longitudinal cohort study. Setting. A 100-bed Veterans Administration LTCF. Participants. All current and newly admitted residents of the LTCF during an 8-week study period. Methods. Nasal swab samples were obtained weekly and cultured on MRSA- selective media, and the cultures were graded for growth on a semiquantitative scale from 0 (no growth) to 6 (heavy growth). Epidemiologic data for the periods before and during the study were collected to assess risk factors for MRSA carriage. Results. Of 83 LTCF residents, 49 (59%) had 1 or more nasal swab cultures that were positive for MRSA; 34 (41%) were consistently culture-negative (designated 'noncarriers'). Of the 49 culture-positive residents, 30 (36% of the total of 83 residents) had all cultures positive for MRSA (designated 'persistent carriers'), and 19 (23% of the 83 residents) had at least 1 culture, but not all cultures, positive for MRSA (designated 'intermittent carriers'). Multivariate analysis showed that participants with at least 1 nasal swab culture positive for MRSA were likely to have had previous hospitalization (odds ratio, 3.9) or wounds (odds ratio, 8.2). Persistent carriers and intermittent carriers did not differ in epidemiologic characteristics but did differ in mean MRSA growth score (3.7 vs 0.7; [image]). Conclusions. Epidemiologic characteristics differed between noncarriers and subjects with at least 1 nasal swab culture positive for MRSA. However, in this LTCF population, only the degree of bacterial colonization (as reflected by mean MRSA growth score) distinguished persistent carriers from intermittent carriers. Understanding the burden of colonization may be important when determining future surveillance and control strategies. JF - Infection Control and Hospital Epidemiology AU - Stone, Nimalie D AU - Lewis, Donna R AU - Lowery, H K AU - Darrow, Lyndsey A AU - Kroll, Catherine M AU - Gaynes, Robert P AU - Jernigan, John A AU - McGowan Jr, John E AU - Tenover, Fred C AU - Richards Jr, Chesley L AD - Emory University School of Medicine and the Rollins School of Public Health, Emory University, the Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, and the Atlanta Veterans Administration Medical Center, Decatur, Georgia., nstone@emory.edu Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 143 EP - 148 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 29 IS - 2 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - Data processing KW - antibiotic resistance KW - Drug resistance KW - Media (selective) KW - colonization KW - Wounds KW - Colonization KW - Multivariate analysis KW - Risk factors KW - Staphylococcus aureus KW - Media (culture) KW - Hospitals KW - R2 23060:Medical and environmental health KW - J 02400:Human Diseases KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19608385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Importance+of+Bacterial+Burden+Among+Methicillin-Resistant+Staphylococcus+aureus+Carriers+in+a+Long-Term+Care+Facility&rft.au=Stone%2C+Nimalie+D%3BLewis%2C+Donna+R%3BLowery%2C+H+K%3BDarrow%2C+Lyndsey+A%3BKroll%2C+Catherine+M%3BGaynes%2C+Robert+P%3BJernigan%2C+John+A%3BMcGowan+Jr%2C+John+E%3BTenover%2C+Fred+C%3BRichards+Jr%2C+Chesley+L&rft.aulast=Stone&rft.aufirst=Nimalie&rft.date=2008-02-01&rft.volume=29&rft.issue=2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F526437 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Colonization; Data processing; Multivariate analysis; Risk factors; Drug resistance; Media (selective); Media (culture); Wounds; Hospitals; antibiotic resistance; colonization; Staphylococcus aureus DO - http://dx.doi.org/10.1086/526437 ER - TY - JOUR T1 - Extended Use of Urinary Catheters in Older Surgical Patients: A Patient Safety Problem? AN - 19608053; 8585019 AB - Objectives. To explore the relationship between the extended postoperative use of indwelling urinary catheters and outcomes for older patients who have undergone cardiac, vascular, gastrointestinal, or orthopedic surgery in skilled nursing facilities and to describe patient and hospital characteristics associated with the extended use of indwelling urinary catheters. Design. Retrospective cohort study. Setting. US acute care hospitals and skilled nursing facilities. Patients. A total of 170,791 Medicare patients aged 65 years or more who were admitted to skilled nursing facilities after discharge from a hospital with a primary diagnosis code indicating major cardiac, vascular, orthopedic, or gastrointestinal surgery in 2001. Main outcome measures. Patient-specific 30-day rate of rehospitalization for urinary tract infection (UTI) and 30-day mortality rate, as well as the risk of having an indwelling urinary catheter at the time of admission to a skilled nursing facility. Results. A total of 39,282 (23.0%) of the postoperative patients discharged to skilled nursing facilities had indwelling urinary catheters. After adjusting for patient characteristics, the patients with catheters had greater odds of rehospitalization for UTI and death within 30 days than patients who did not have catheters. The adjusted odds ratios (aORs) for UTI ranged from 1.34 for patients who underwent gastrointestinal surgery to 1.85 for patients who underwent cardiac surgery; the aORs for death ranged from 1.25 for cardiac surgery to 1.48 for orthopedic surgery and for gastrointestinal surgery. After controlling for patient characteristics, hospitalization in the northeastern or southern regions of the United States was associated with a lower likelihood of having an indwelling urinary catheter, compared with hospitalization in the western region ([image] vs [image]). Conclusions. Extended postoperative use of indwelling urinary catheters is associated with poor outcomes for older patients. The likelihood of having an indwelling urinary catheter at the time of discharge after major surgery is strongly associated with a hospital's geographic region, which reflects a variation in practice that deserves further study. JF - Infection Control and Hospital Epidemiology AU - Wald, Heidi L AU - Epstein, Anne M AU - Radcliff, Tiffany A AU - Kramer, Andrew M AD - Division of Health Care Policy and Research, University of Colorado at Denver and Health Sciences Center, Aurora, and the Denver Veterans Administration Medical Center, Denver, Colorado., heidi.wald@uchsc.edu Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 116 EP - 124 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 29 IS - 2 SN - 0899-823X, 0899-823X KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - USA KW - safety engineering KW - Urine KW - medical instruments KW - Infection KW - surgery KW - Hospitals KW - H 13000:Medical Safety KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19608053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Extended+Use+of+Urinary+Catheters+in+Older+Surgical+Patients%3A+A+Patient+Safety+Problem%3F&rft.au=Wald%2C+Heidi+L%3BEpstein%2C+Anne+M%3BRadcliff%2C+Tiffany+A%3BKramer%2C+Andrew+M&rft.aulast=Wald&rft.aufirst=Heidi&rft.date=2008-02-01&rft.volume=29&rft.issue=2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F526433 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; safety engineering; Urine; medical instruments; Infection; surgery; Hospitals; USA DO - http://dx.doi.org/10.1086/526433 ER - TY - JOUR T1 - Benign Prostatic Hyperplasia. Part 2-Management AN - 57246982; 200820794 AB - Management of benign prostatic hyperplasia (BPH) is mainly directed at improving bothersome lower urinary tract symptoms. The vast majority of men with these symptoms initially present to primary care seeking information about the risks and benefits of available treatments. Few men require urgent referral to a specialist for additional diagnostic testing or management. This article provides evidence to guide primary care doctors in the treatment of men with lower urinary tract symptoms, with emphasis on BPH. A previous article discussed diagnosis. Figures, References. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Wilt, Timothy J AU - N'Dow, James AD - Center for Chronic Disease Outcomes Research, Minneapolis, US tim.wilt@med.va.gov Y1 - 2008/01/26/ PY - 2008 DA - 2008 Jan 26 SP - 206 EP - 210 PB - British Medical Association, BMJ Publishing Group, London UK VL - 336 IS - 7637 SN - 0959-535X, 0959-535X KW - Diagnosis KW - Benign prostatic hyperplasia KW - Treatment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57246982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Benign+Prostatic+Hyperplasia.+Part+2-Management&rft.au=Wilt%2C+Timothy+J%3BN%27Dow%2C+James&rft.aulast=Wilt&rft.aufirst=Timothy&rft.date=2008-01-26&rft.volume=336&rft.issue=7637&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.39433.670718.AD LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Benign prostatic hyperplasia; Diagnosis; Treatment DO - http://dx.doi.org/10.1136/bmj.39433.670718.AD ER - TY - JOUR T1 - Inverse correlation between the extent of N-glycan branching and intercellular adhesion in epithelia. Contribution of the Na,K-ATPase beta1 subunit. AN - 70216484; 18025087 AB - The majority of cell adhesion molecules are N-glycosylated, but the role of N-glycans in intercellular adhesion in epithelia remains ill-defined. Reducing N-glycan branching of cellular glycoproteins by swainsonine, the inhibitor of N-glycan processing, tightens and stabilizes cell-cell junctions as detected by a 3-fold decrease in the paracellular permeability and a 2-3-fold increase in the resistance of the adherens junction proteins to extraction by non-ionic detergent. In addition, exposure of cells to swainsonine inhibits motility of MDCK cells. Mutagenic removal of N-glycosylation sites from the Na,K-ATPase beta(1) subunit impairs cell-cell adhesion and decreases the effect of swainsonine on the paracellular permeability of the cell monolayer and also on detergent resistance of adherens junction proteins, indicating that the extent of N-glycan branching of this subunit is important for intercellular adhesion. The N-glycans of the Na,K-ATPase beta(1) subunit and E-cadherin are less complex in tight renal epithelia than in the leakier intestinal epithelium. The complexity of the N-glycans linked to these proteins gradually decreases upon the formation of a tight monolayer from dispersed MDCK cells. This correlates with a cell-cell adhesion-induced increase in expression of GnT-III (stops N-glycan branching) and a decrease in expression of GnTs IVC and V (promote N-glycan branching) as detected by real-time quantitative PCR. Consistent with these results, partial silencing of the gene encoding GnT-III increases branching of N-glycans linked to the Na,K-ATPase beta(1) subunit and other glycoproteins and results in a 2-fold increase in the paracellular permeability of MDCK cell monolayers. These results suggest epithelial cells can regulate tightness of cell junctions via remodeling of N-glycans, including those linked to the Na,K-ATPase beta(1)-subunit. JF - The Journal of biological chemistry AU - Vagin, Olga AU - Tokhtaeva, Elmira AU - Yakubov, Iskandar AU - Shevchenko, Eugenia AU - Sachs, George AD - Department of Physiology, School of Medicine, University of California, Los Angeles, Veterans Administration Greater Los Angeles Health Care System, Los Angeles, California 90073, USA. olgav@ucla.edu Y1 - 2008/01/25/ PY - 2008 DA - 2008 Jan 25 SP - 2192 EP - 2202 VL - 283 IS - 4 SN - 0021-9258, 0021-9258 KW - Cell Adhesion Molecules KW - 0 KW - Enzyme Inhibitors KW - Glucans KW - Oligosaccharides, Branched-Chain KW - N-Acetylglucosaminyltransferases KW - EC 2.4.1.- KW - Sodium-Potassium-Exchanging ATPase KW - EC 3.6.3.9 KW - Swainsonine KW - RSY4RK37KQ KW - Index Medicus KW - Animals KW - Swainsonine -- pharmacology KW - Cell Adhesion -- physiology KW - Epithelium -- enzymology KW - Rabbits KW - Cell Movement -- physiology KW - Cell Movement -- drug effects KW - Dogs KW - Enzyme Inhibitors -- pharmacology KW - Cell Adhesion -- drug effects KW - Cell Line KW - N-Acetylglucosaminyltransferases -- antagonists & inhibitors KW - N-Acetylglucosaminyltransferases -- biosynthesis KW - Protein Modification, Translational -- physiology KW - Sodium-Potassium-Exchanging ATPase -- metabolism KW - Epithelial Cells -- enzymology KW - Intercellular Junctions -- metabolism KW - Sodium-Potassium-Exchanging ATPase -- genetics KW - Glucans -- biosynthesis KW - Cell Adhesion Molecules -- metabolism KW - Protein Modification, Translational -- drug effects KW - Oligosaccharides, Branched-Chain -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70216484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Inverse+correlation+between+the+extent+of+N-glycan+branching+and+intercellular+adhesion+in+epithelia.+Contribution+of+the+Na%2CK-ATPase+beta1+subunit.&rft.au=Vagin%2C+Olga%3BTokhtaeva%2C+Elmira%3BYakubov%2C+Iskandar%3BShevchenko%2C+Eugenia%3BSachs%2C+George&rft.aulast=Vagin&rft.aufirst=Olga&rft.date=2008-01-25&rft.volume=283&rft.issue=4&rft.spage=2192&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-26 N1 - Date created - 2008-01-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2006 May 12;281(19):13038-46 [16537539] J Biol Chem. 2003 Sep 12;278(37):34794-803 [12826673] J Biol Chem. 2006 Aug 11;281(32):23138-49 [16682414] Cancer Res. 2003 Sep 1;63(17):5363-9 [14500369] Clin Cancer Res. 2004 Mar 1;10(5):1773-9 [15014031] J Biol Chem. 2004 May 7;279(19):19747-54 [14998999] Physiologist. 1977 Feb;20(1):10-8 [16304] J Antibiot (Tokyo). 1985 Jul;38(7):936-40 [3928564] J Cell Biol. 1986 Feb;102(2):457-68 [3511070] J Cell Biol. 1988 Oct;107(4):1575-87 [3049625] J Cell Biol. 1990 Jan;110(1):165-74 [1688561] J Biol Chem. 1993 Jul 5;268(19):13914-9 [8390982] Am J Physiol. 1995 Feb;268(2 Pt 2):F285-95 [7864168] J Cell Biol. 1996 Feb;132(3):451-63 [8636221] Annu Rev Cell Dev Biol. 1997;13:119-46 [9442870] Am J Physiol. 1998 Nov;275(5 Pt 2):F633-50 [9815123] J Cell Biol. 1963 May;17:375-412 [13944428] J Biol Chem. 2005 Mar 4;280(9):8332-42 [15615721] Adv Drug Deliv Rev. 2005 Apr 25;57(6):815-55 [15820555] Oncology. 2005;69(4):301-10 [16282710] J Biol Chem. 2005 Dec 30;280(52):43159-67 [16230337] Am J Physiol Renal Physiol. 2006 Feb;290(2):F241-50 [16403837] J Urol. 2006 Jan;175(1):90-3; discussion 93 [16406879] Annu Rev Physiol. 2006;68:403-29 [16460278] Annu Rev Cell Dev Biol. 2006;22:207-35 [16771626] Am J Pathol. 2006 Dec;169(6):1901-9 [17148655] Development. 2007 Jan;134(1):147-55 [17164420] J Biol Chem. 2006 Dec 22;281(51):39573-87 [17052981] Mol Biol Cell. 2007 Jan;18(1):189-200 [17093058] Biochem Cell Biol. 2006 Dec;84(6):870-80 [17215874] Cell Biochem Biophys. 2006;46(3):303-16 [17272855] Cell Mol Biol (Noisy-le-grand). 2006;52(8):41-7 [17535735] J Biol Chem. 2000 Jan 21;275(3):1976-86 [10636900] Nat Med. 2000 Mar;6(3):306-12 [10700233] Clin Cancer Res. 2000 May;6(5):1772-7 [10815896] Genomics. 2000 Aug 15;68(1):41-56 [10950925] Mol Biol Cell. 2001 Feb;12(2):279-95 [11179415] J Neurochem. 2001 Jun;77(5):1301-9 [11389181] J Membr Biol. 2002 Jul 15;188(2):151-62 [12172640] Nucleic Acids Res. 2001 May 1;29(9):e45 [11328886] J Cell Biol. 2003 Jun 9;161(5):979-89 [12782686] Development. 2003 Oct;130(20):4963-74 [12930776] Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2675-85 [16723486] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Benign Prostatic Hyperplasia. Part 1-Diagnosis AN - 57251679; 200820793 AB - Lower urinary tract symptoms in older men are common and bothersome, leading to considerable use of healthcare services. Symptoms may reflect obstructive voiding (weak urine flow, hesitancy, straining, and incomplete emptying) or bladder storage problems (frequency, urgency, and nocturia). Lower urinary tract symptoms are often considered to be due to benign prostatic hyperplasia (BPH) or benign prostatic enlargement. However, such symptoms are common in women, as well as in men with prostate glands that are not enlarged.3 4 The symptoms can be caused by overactivity of the bladders detrusor muscle, non-urological conditions, medications, or lifestyle factors. This article provides evidence to guide primary care doctors in the diagnosis of men with lower urinary tract symptoms, with an emphasis on BPH. A second article will focus on management. Tables, Figures, References. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Wilt, Timothy J AU - N'Dow, James AD - Center for Chronic Disease Outcomes Research, Minneapolis, US tim.wilt@med.va.gov Y1 - 2008/01/19/ PY - 2008 DA - 2008 Jan 19 SP - 146 EP - 149 PB - British Medical Association, BMJ Publishing Group, London UK VL - 336 IS - 7636 SN - 0959-535X, 0959-535X KW - Symptoms KW - Diagnosis KW - Pathology KW - Benign prostatic hyperplasia KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57251679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Benign+Prostatic+Hyperplasia.+Part+1-Diagnosis&rft.au=Wilt%2C+Timothy+J%3BN%27Dow%2C+James&rft.aulast=Wilt&rft.aufirst=Timothy&rft.date=2008-01-19&rft.volume=336&rft.issue=7636&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.39421.685023.AE LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Benign prostatic hyperplasia; Pathology; Symptoms; Diagnosis DO - http://dx.doi.org/10.1136/bmj.39421.685023.AE ER - TY - JOUR T1 - Treatment of Clostridium difficile Infection AN - 19647852; 8372856 AB - Recent outbreaks of Clostridium difficile infection (CDI) in North America have been due to a more virulent, possibly more resistant strain that causes more-severe disease, making prompt recognition of cases and optimal management of infection essential for a successful therapeutic outcome. Treatment algorithms are presented to help guide the management of patients with CDI. Metronidazole has been recommended as initial therapy since the late 1990s and continues to be the first choice for all but seriously ill patients and those with complicated or fulminant infections or multiple recurrences of CDI, for whom vancomycin is recommended. Other options for recurrent CDI, such as probiotics and currently available anion-exchange resins, have limited efficacy and are potentially harmful. Intravenous immunoglobulin may benefit patients with refractory, recurrent, or severe disease, but no controlled data are available. Two antimicrobials available in the United States for other indications, nitazoxanide and rifaximin, have been used successfully for CDI treatment but, like metronidazole, lack United States Food and Drug Administration approval for this indication. Experimental treatments currently in clinical development include a toxin-binding polymer, tolevamer; 2 poorly absorbed antimicrobials, OPT-80 (formerly known as Difimicin) and ramoplanin; monoclonal antibodies; and a C. difficile vaccine. JF - Clinical Infectious Diseases AU - Gerding, D N AU - Muto, CA AU - Owens, RC Jr AD - Hines Veterans Affairs Hospital, 5th Ave. & Roosevelt Rd., PO Box 5000, Hines, IL 60141, USA, dale.gerding2@va.gov Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - S32 EP - S42 VL - 46 IS - S1 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Metronidazole KW - Intravenous administration KW - Resins KW - Data processing KW - Monoclonal antibodies KW - probiotics KW - Algorithms KW - Vancomycin KW - Clostridium difficile KW - Vaccines KW - Immunoglobulins KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19647852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Treatment+of+Clostridium+difficile+Infection&rft.au=Gerding%2C+D+N%3BMuto%2C+CA%3BOwens%2C+RC+Jr&rft.aulast=Gerding&rft.aufirst=D&rft.date=2008-01-15&rft.volume=46&rft.issue=S1&rft.spage=S32&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Metronidazole; Resins; Intravenous administration; Data processing; Monoclonal antibodies; Algorithms; probiotics; Vancomycin; Vaccines; Immunoglobulins; Clostridium difficile ER - TY - JOUR T1 - Measures to Control and Prevent Clostridium difficile Infection AN - 19646759; 8372857 AB - Control of Clostridium difficile infection (CDI) outbreaks in health care facilities presents significant challenges to infection control specialists and other health care workers. C. difficile spores survive routine environmental cleaning with detergents and hand hygiene with alcohol-based gels. Enhanced cleaning of all potentially contaminated surfaces with 10% sodium hypochlorite reduces the environmental burden of C. difficile, and use of barrier precautions reduces C. difficile transmission. Thorough handwashing with chlorhexidine or with soap and water has been shown to be effective in removing C. difficile spores from hands. Achieving high-level compliance with these measures is a major challenge for infection control programs. Good antimicrobial stewardship complements infection control efforts and environmental interventions to provide a comprehensive strategy to prevent and control outbreaks of CDI. The efficacy of metronidazole or vancomycin prophylaxis to prevent CDI in patients who are receiving other antimicrobials is unproven, and treatment with these agents is ineffective against C. difficile in asymptomatic carriers. JF - Clinical Infectious Diseases AU - Gerding, D N AU - Muto, CA AU - Owens, RC Jr AD - Hines Veterans Affairs Hospital, 5th Ave. & Roosevelt Rd., P.O. Box 5000, Hines, IL 60141, USA, dale.gerding2@va.gov Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - S43 EP - S49 VL - 46 IS - S1 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Metronidazole KW - Chlorhexidine KW - Detergents KW - Control programs KW - Sodium hypochlorite KW - Hand KW - Infection KW - Medical personnel KW - Disease transmission KW - Gels KW - Prophylaxis KW - Vancomycin KW - Clostridium difficile KW - Soaps KW - Hygiene KW - Spores KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19646759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Measures+to+Control+and+Prevent+Clostridium+difficile+Infection&rft.au=Gerding%2C+D+N%3BMuto%2C+CA%3BOwens%2C+RC+Jr&rft.aulast=Gerding&rft.aufirst=D&rft.date=2008-01-15&rft.volume=46&rft.issue=S1&rft.spage=S43&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Metronidazole; Chlorhexidine; Detergents; Control programs; Sodium hypochlorite; Hand; Infection; Medical personnel; Disease transmission; Gels; Prophylaxis; Vancomycin; Soaps; Spores; Hygiene; Clostridium difficile ER - TY - JOUR T1 - The Maxwell Finland Lecture: For the Duration-Rational Antibiotic Administration in an Era of Antimicrobial Resistance and Clostridium difficile AN - 19530438; 8231284 AB - Antimicrobial resistance is frequently associated with clinical use of antibiotics. This close association suggests that efforts to manage our use of these potent agents can have an impact on the prevalence of resistance. Unfortunately, one size does not fit all when considering the response of bacterial pathogens to antimicrobial exposure. Measures that may prevent resistance in some species (such as using multiple antibiotics to treat tuberculosis) may exacerbate the problem of resistance in others (such as Pseudomonas aeruginosa or Acinetobacter baumannil). The simplest approach is to use fewer antibiotics and thereby apply less selective pressure to the prevalent flora. Among available strategies to reduce use, reductions in length of antimicrobial regimens are the safest and are likely to be the most palatable to practicing clinicians. Studies are urgently needed to define minimal lengths of therapy to ensure that efforts at reduced use are safe and effective. JF - Clinical Infectious Diseases AU - Rice, L B AD - Medical Service 111(W), Louis Stokes Cleveland VAMC, 10701 East Blvd., Cleveland, OH 44106, USA, louis.rice@va.gov Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - 491 EP - 496 VL - 46 IS - 4 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Acinetobacter KW - Mycobacterium KW - Drug resistance KW - Clostridium difficile KW - Antibiotics KW - Tuberculosis KW - Pathogens KW - Pseudomonas aeruginosa KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19530438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=The+Maxwell+Finland+Lecture%3A+For+the+Duration-Rational+Antibiotic+Administration+in+an+Era+of+Antimicrobial+Resistance+and+Clostridium+difficile&rft.au=Rice%2C+L+B&rft.aulast=Rice&rft.aufirst=L&rft.date=2008-01-15&rft.volume=46&rft.issue=4&rft.spage=491&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Drug resistance; Tuberculosis; Antibiotics; Pathogens; Acinetobacter; Mycobacterium; Clostridium difficile; Pseudomonas aeruginosa ER - TY - JOUR T1 - A prospective study to examine persistent HCV reinfection in injection drug users who have previously cleared the virus AN - 57250930; 200817137 AB - Background Many HCV-infected persons with recent or ongoing injection drug use (IDU) do not receive HCV treatment due to the perceived risk of HCV reinfection. There are few prospective studies investigating HCV reinfection among IDUs. Methods Two hundred and twenty-four persons with past or ongoing IDU were followed from 1997 to 2007. Baseline and every 6-month follow-up data were collected including demographics, IDU, and sexual behaviors. Serum was tested for the presence of HCV antibody and serially for HCV RNA. Resolvers were defined as HCV antibody and RIBA positive and RNA negative at two consecutive time points or as becoming HCV RNA negative after HCV antiviral treatment. Reinfection was defined by the presence of HCV RNA at >=2 visits. Results One hundred and eighty-six persons had chronic HCV and 38 had resolved HCV. The resolvers were followed for a total of 214 person-years. Forty-two percent of resolvers reported ongoing IDU, representing 58 person-years of IDU. Only one reinfection occurred in the resolvers, for a reinfection rate of 0.47 cases/100 person-years of follow-up. The single reinfection, which occurred in a person who continued to inject drugs, represents a reinfection rate of 1.75 cases/100 person-years of IDU. Conclusion These data suggest that despite ongoing IDU, persistent HCV reinfection is lower than previously published. This can be attributed to a more clinically relevant definition of reinfection. This information will better help clinicians make informed decisions regarding HCV treatment options for patients who may continue to inject illicit drugs. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Currie, Sue L AU - Ryan, James C AU - Tracy, Daniel AU - Wright, Teresa L AU - George, Sally AU - McQuaid, Rosemary AU - Kim, Michael AU - Shen, Hui AU - Monto, Alexander AD - Department of Medicine, University of California, San Francisco, San Francisco, CA, USA sue.currie@va.gov Y1 - 2008/01/11/ PY - 2008 DA - 2008 Jan 11 SP - 148 EP - 154 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 93 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Hepatitis KW - Hepatitis C Virus KW - IDUs KW - HCV reinfection KW - HCV resolution KW - Risk behaviour KW - Needle use KW - Hepatitis C KW - Intravenous drug addiction KW - Treatment KW - Recurrence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57250930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=A+prospective+study+to+examine+persistent+HCV+reinfection+in+injection+drug+users+who+have+previously+cleared+the+virus&rft.au=Currie%2C+Sue+L%3BRyan%2C+James+C%3BTracy%2C+Daniel%3BWright%2C+Teresa+L%3BGeorge%2C+Sally%3BMcQuaid%2C+Rosemary%3BKim%2C+Michael%3BShen%2C+Hui%3BMonto%2C+Alexander&rft.aulast=Currie&rft.aufirst=Sue&rft.date=2008-01-11&rft.volume=93&rft.issue=1-2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.09.011 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-09-03 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Hepatitis C; Needle use; Risk behaviour; Treatment; Intravenous drug addiction; Recurrence DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.09.011 ER - TY - JOUR T1 - The relationship between measures of nutritional status and masticatory function in untreated patients with head and neck cancer. AN - 742773937; pmid-18083420 AB - PURPOSE: Nearly 40% of newly diagnosed patients with head and neck cancer are malnourished before treatment begins with many researchers ascribing the malnutrition to a paucity of teeth. We attempted to determine if inadequate numbers of occluding pairs of teeth, rather than mere numbers of teeth, in newly hospitalized, untreated head and neck cancer patients correlates with nutritional status parameters used to identify those at heightened risk for malnutrition-related complications. PATIENTS AND METHODS: Patients and cancer-free, matched controls were evaluated for malnutrition (body mass index < or = 20 [weight (kg)/height (m2)]), serum albumin < or = 2.7 g/dL, hemoglobin < or = 11.9 g/dL, and total lymphocyte count < or = 1,449/muL), and inadequate numbers of occluding pairs of teeth variably defined as less than 5 "posterior pairs" of occluding teeth or less than 6 or 7 "total pairs" of occluding teeth. RESULTS: Head and neck cancer patients had significantly lower body mass index (P = .005) and total lymphocyte count (P = .019) than controls, but there were no significant correlations between the nutritional and dental variables in either group. CONCLUSIONS: Untreated head and neck cancer patients frequently have nutritional status parameters indicating heightened risk for malnutrition-related complications but inadequate masticatory function is not a causative factor. JF - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons AU - Friedlander, Arthur H AU - Tajima, Tracey AU - Kawakami, Kyle T AU - Wang, Marilene B AU - Tomlinson, James AD - Veterans Affairs Greater Los Angeles Healthcare System, CA 90073, USA. arthur.friedlander@med.va.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 85 EP - 92 VL - 66 IS - 1 SN - 0278-2391, 0278-2391 KW - National Library of Medicine KW - Malnutrition -- etiology KW - Anodontia -- radiography KW - Hemoglobins -- analysis KW - Lymphocytes -- blood KW - Serum Albumin -- analysis KW - Aged, 80 and over KW - Epidemiologic Methods KW - Humans KW - Anodontia -- etiology KW - Aged KW - Middle Aged KW - Body Mass Index KW - Male KW - Nutritional Status KW - Head and Neck Neoplasms -- complications KW - Mastication -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742773937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.atitle=The+relationship+between+measures+of+nutritional+status+and+masticatory+function+in+untreated+patients+with+head+and+neck+cancer.&rft.au=Friedlander%2C+Arthur+H%3BTajima%2C+Tracey%3BKawakami%2C+Kyle+T%3BWang%2C+Marilene+B%3BTomlinson%2C+James&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2008-01-01&rft.volume=66&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.issn=02782391&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Behavioral reactivity and addiction: the adaptation of behavioral response to reward opportunities. AN - 70338362; 18305282 AB - Persons recovering from addiction must refrain from drug use even when the opportunity to use exists. Understanding how behavioral response to drug reward opportunities is modified is key to treating addiction. Most effective behavioral therapies encourage patients to increase reinforcement opportunities by engaging unidentified sources of nondrug reward. The authors integrate transdisciplinary research on the brain and behavioral effects of increasing reward availability to demonstrate one neurobiological mechanism by which behavioral therapies help patients abstain. Explicating neurobiological processes underlying psychotherapy provides predictions about the interaction between dopaminergic medications and therapy and the impact of individual differences in dopamine receptor expression on addiction vulnerability. JF - The Journal of neuropsychiatry and clinical neurosciences AU - Trafton, Jodie A AU - Gifford, Elizabeth V AD - VA Palo Alto Healthcare System, Stanford University Medical School, Center for Health Care Evaluation, Menlo Park, CA 94025, USA. Jodie.Trafton@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 23 EP - 35 VL - 20 IS - 1 SN - 0895-0172, 0895-0172 KW - Index Medicus KW - Animals KW - Humans KW - Substance-Related Disorders -- physiopathology KW - Reward KW - Adaptation, Physiological -- physiology KW - Behavior, Addictive -- physiopathology KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70338362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuropsychiatry+and+clinical+neurosciences&rft.atitle=Behavioral+reactivity+and+addiction%3A+the+adaptation+of+behavioral+response+to+reward+opportunities.&rft.au=Trafton%2C+Jodie+A%3BGifford%2C+Elizabeth+V&rft.aulast=Trafton&rft.aufirst=Jodie&rft.date=2008-01-01&rft.volume=20&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuropsychiatry+and+clinical+neurosciences&rft.issn=08950172&rft_id=info:doi/10.1176%2Fjnp.2008.20.1.23 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-02 N1 - Date created - 2008-02-28 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1176/jnp.2008.20.1.23 ER - TY - JOUR T1 - Post-marketing surveillance of ischaemic optic neuropathy in male veterans co-prescribed phosphodiesterase-5 inhibitors with organic nitrates or alpha-blockers. AN - 70336424; 18302448 AB - The cause of nonarteritic anterior ischaemic optic neuropathy (ION) is unknown, although assumed to be related to transient vascular insufficiency of the optic nerve head. Because the interaction of phosphodiesterase-5 (PDE-5) inhibitors with either an organic nitrate or alpha-blocker may theoretically increase the risk of ION, we conducted a screening study to determine if such a risk might exist. Retrospective cohort study of male veterans with ION and possible ION. The national Veterans Health Administration (VHA) clinical database was cross-referenced (linked) with the VHA pharmacy database looking for specific drug combinations. Compared with no use, the relative risk (RR) of ION and possible ION for men prescribed both PDE-5 inhibitor and organic nitrate was 1.41 (95% CI 0.85, 2.33). Similarly, the RR of ION and possible ION with concurrent prescription of PDE-5 inhibitor and alpha-blocker was 1.21 (95% CI 1.01, 1.44). When risk was measured against use of a PDE-5 inhibitor alone, the RR was 1.29 (95% CI 0.78, 2.16) for PDE-5 inhibitor and organic nitrate and 1.12 (95% CI 0.92, 1.35) for PDE-5 inhibitor and alpha-blocker. We linked two large national databases to screen for a potentially important drug-drug-disease interaction. There was no increase in risk of ION and possible ION in men dispensed a PDE-5 inhibitor with either organic nitrates or an alpha-blocker compared with men dispensed PDE-5 inhibitor alone. An incidental observation that a substantial number of men were prescribed both an organic nitrate and a PDE-5 inhibitor within a single dispensing period raises concerns over non-ocular safety issues. The wisdom of co-dispensing medications that are contraindicated may deserve a broader audience. JF - Drug safety AU - French, Dustin D AU - Margo, Curtis E AD - VISN-8 Patient Safety Center of Inquiry, James A. Haley VA Hospital, Tampa, Florida, USA. Dustin.French@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 241 EP - 247 VL - 31 IS - 3 SN - 0114-5916, 0114-5916 KW - Adrenergic alpha-Antagonists KW - 0 KW - Nitrates KW - Phosphodiesterase Inhibitors KW - Index Medicus KW - United States KW - Drug Interactions KW - Humans KW - Retrospective Studies KW - Aged KW - Veterans KW - Risk KW - United States Department of Veterans Affairs KW - Cohort Studies KW - Databases, Factual KW - Product Surveillance, Postmarketing KW - Middle Aged KW - Male KW - Optic Neuropathy, Ischemic -- chemically induced KW - Nitrates -- adverse effects KW - Adrenergic alpha-Antagonists -- adverse effects KW - Phosphodiesterase Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70336424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Post-marketing+surveillance+of+ischaemic+optic+neuropathy+in+male+veterans+co-prescribed+phosphodiesterase-5+inhibitors+with+organic+nitrates+or+alpha-blockers.&rft.au=French%2C+Dustin+D%3BMargo%2C+Curtis+E&rft.aulast=French&rft.aufirst=Dustin&rft.date=2008-01-01&rft.volume=31&rft.issue=3&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=01145916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-18 N1 - Date created - 2008-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The association between healthy lifestyle behaviors and relapse rates in a homeless veteran population. AN - 70319706; 18293233 AB - This study evaluates the association between Healthy Lifestyle Behaviors (HLBs) and relapse rates in a homeless residential rehabilitation program. Ninety-seven homeless veterans with Substance Dependence in Early Remission were evaluated. Veterans recorded recreational, social, coping/spiritual, and substance recovery activities. Those who relapsed during residential treatment were compared to those who did not. Higher numbers of HLBs were associated with lower relapse rates during treatment. No differences were found between the two groups in the number of recovery activities performed. HLBs proved better predictors of success than recovery behaviors. Implications and limitations are discussed. JF - The American journal of drug and alcohol abuse AU - LePage, James P AU - Garcia-Rea, Elizabeth A AD - University of Texas Southwestern Medical School, VA North Texas Health Care System, Dallas 75216, USA. james.lepage@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 171 EP - 176 VL - 34 IS - 2 SN - 0095-2990, 0095-2990 KW - Index Medicus KW - Substance Abuse Treatment Centers KW - Logistic Models KW - Risk Factors KW - Humans KW - Adult KW - Texas KW - Patient Discharge KW - Recurrence KW - Male KW - Life Style KW - Veterans -- psychology KW - Homeless Persons -- psychology KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70319706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=The+association+between+healthy+lifestyle+behaviors+and+relapse+rates+in+a+homeless+veteran+population.&rft.au=LePage%2C+James+P%3BGarcia-Rea%2C+Elizabeth+A&rft.aulast=LePage&rft.aufirst=James&rft.date=2008-01-01&rft.volume=34&rft.issue=2&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/10.1080%2F00952990701877060 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/00952990701877060 ER - TY - JOUR T1 - Major depression and comorbid substance use disorders. AN - 70302936; 18281835 AB - The presentation of major depressive disorder is often complicated by the co-occurrence of substance use disorders, such as alcohol and illicit drug abuse or dependence. The article reviews the recent systematic research on the distinguishing baseline characteristics including demographic characteristics and the influence of family history, and clinical features such as depressive symptomatology and suicidal ideation, and the outcome of treatment for depression in patients with comorbid major depressive disorder and substance use disorders. The review also addresses the possible explanations cited in the literature as to why these two disorders tend to co-occur and the implications of the comorbidity of these illnesses on treatment. Nearly one-third of patients with major depressive disorder also have substance use disorders, and the comorbidity yields higher risk of suicide and greater social and personal impairment as well as other psychiatric conditions. Although the treatment of comorbid major depressive disorder and substance use disorders with medication is likely effective, the differential treatment effects based on substance use disorder comorbidity have been understudied. Emerging results of recent studies comparing the outcome of major depressive disorder patients with comorbid major depressive disorder and substance use disorders suggest that there are fewer differential effects based on comorbidity than previously anticipated by older assumptions from smaller, less methodologically rigorous studies. JF - Current opinion in psychiatry AU - Davis, Lori AU - Uezato, Akihito AU - Newell, Jason M AU - Frazier, Elizabeth AD - VA Medical Center, Research and Development, Tuscaloosa, AL 35404, USA. lori.davis@va.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 14 EP - 18 VL - 21 IS - 1 SN - 0951-7367, 0951-7367 KW - Antidepressive Agents KW - 0 KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Suicide, Attempted -- psychology KW - Combined Modality Therapy KW - Humans KW - Genetic Predisposition to Disease -- psychology KW - Suicide, Attempted -- prevention & control KW - Comorbidity KW - Cross-Sectional Studies KW - Suicide, Attempted -- statistics & numerical data KW - Psychotherapy KW - Risk Factors KW - Adult KW - Antidepressive Agents -- therapeutic use KW - Female KW - Male KW - Alcoholism -- rehabilitation KW - Substance-Related Disorders -- diagnosis KW - Depressive Disorder, Major -- diagnosis KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Depressive Disorder, Major -- psychology KW - Depressive Disorder, Major -- epidemiology KW - Depressive Disorder, Major -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70302936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+psychiatry&rft.atitle=Major+depression+and+comorbid+substance+use+disorders.&rft.au=Davis%2C+Lori%3BUezato%2C+Akihito%3BNewell%2C+Jason+M%3BFrazier%2C+Elizabeth&rft.aulast=Davis&rft.aufirst=Lori&rft.date=2008-01-01&rft.volume=21&rft.issue=1&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+psychiatry&rft.issn=09517367&rft_id=info:doi/10.1097%2FYCO.0b013e3282f32408 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-09 N1 - Date created - 2008-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/YCO.0b013e3282f32408 ER - TY - JOUR T1 - Myths and facts about safe patient handling in rehabilitation. AN - 70250548; 18236887 AB - As the incidence of injuries associated with patient-handling tasks remains high in the rehabilitation community, interdisciplinary discussions on optimal methods for preventing injuries and ensuring good care continue. A national task force consisting of representatives from the Association of Rehabilitation Nurses, the American Physical Therapy Association, and the Veterans Health Administration identified myths that have been promulgated on both sides of the discussion, focusing especially on rehabilitation practices. The purpose of this article is to dispel these myths by using evidence-based methods. Evidence should be applied in discussions of safe patient handling, and although concern about patient outcomes is critical, there is no evidence that the use of patient-handling technology undermines rehabilitation goals and strong evidence that these practices enhance the safety of rehabilitation care providers. Further research on the impact of safe patient-handling practices on rehabilitation goals and continued communication between rehabilitation providers are recommended. JF - Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses AU - Nelson, Audrey AU - Harwood, Kenneth J AU - Tracey, Catherine A AU - Dunn, Kathleen L AD - Patient Safety Center of Inquiry, James A. Haley Veterans Administration Medical Center, Tampa, FL 33612, USA. audrey.nelson@va.gov PY - 2008 SP - 10 EP - 17 VL - 33 IS - 1 SN - 0278-4807, 0278-4807 KW - Nursing KW - Severity of Illness Index KW - Occupational Health KW - Physical Therapy Modalities -- nursing KW - Cooperative Behavior KW - Evidence-Based Medicine KW - Human Engineering KW - Physical Therapy Modalities -- instrumentation KW - Attitude of Health Personnel KW - Humans KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- etiology KW - Activities of Daily Living KW - Outcome Assessment (Health Care) KW - Organizational Objectives KW - Equipment and Supplies, Hospital -- utilization KW - Interprofessional Relations KW - Patient Care Team -- organization & administration KW - Musculoskeletal Diseases -- etiology KW - Musculoskeletal Diseases -- prevention & control KW - Nursing Evaluation Research KW - Health Knowledge, Attitudes, Practice KW - Incidence KW - Occupational Diseases -- epidemiology KW - Equipment and Supplies, Hospital -- economics KW - Musculoskeletal Diseases -- epidemiology KW - Prevalence KW - Rehabilitation Nursing -- organization & administration KW - Lifting -- adverse effects KW - Safety Management -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70250548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rehabilitation+nursing+%3A+the+official+journal+of+the+Association+of+Rehabilitation+Nurses&rft.atitle=Myths+and+facts+about+safe+patient+handling+in+rehabilitation.&rft.au=Nelson%2C+Audrey%3BHarwood%2C+Kenneth+J%3BTracey%2C+Catherine+A%3BDunn%2C+Kathleen+L&rft.aulast=Nelson&rft.aufirst=Audrey&rft.date=2008-01-01&rft.volume=33&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Rehabilitation+nursing+%3A+the+official+journal+of+the+Association+of+Rehabilitation+Nurses&rft.issn=02784807&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-13 N1 - Date created - 2008-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment adherence and illness insight in veterans with bipolar disorder. AN - 70211816; 18195637 AB - Insight into the perceived value of psychotherapy and pharmacological treatment may improve adherence to medication regimens among patients with bipolar disorder, because patients are more likely to take medication they believe will make them better. We conducted a cross-sectional survey of patients recruited into the Continuous Improvement for Veterans in Care-Mood Disorders (CIVIC-MD; July 2004-July 2006), assessing therapeutic insight and 2 measures of medication adherence: the Morisky scale of intrapersonal barriers and missing any doses the previous 4 days. Among 435 patients with bipolar disorder, 27% had poor adherence based on missed dose and 46% had poor adherence based on the Morisky. In multivariable models, greater insight into medication was negatively associated with both measures of poor adherence. Odds of poor adherence increased for women, African Americans, mania, and hazardous drinking. The association of mutable factors-hazardous drinking, manic symptoms, and insight-could represent an opportunity to improve adherence. JF - The Journal of nervous and mental disease AU - Copeland, Laurel A AU - Zeber, John E AU - Salloum, Ihsan M AU - Pincus, Harold A AU - Fine, Michael J AU - Kilbourne, Amy M AD - South Texas Veterans Health Care System, VERDICT, 7400 Merton Minter (11c6), San Antonio, TX 78229-4404, USA. laurel.copeland@va.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 16 EP - 21 VL - 196 IS - 1 KW - Anticonvulsants KW - 0 KW - Antimanic Agents KW - Abridged Index Medicus KW - Index Medicus KW - Awareness -- drug effects KW - Combined Modality Therapy KW - Humans KW - European Continental Ancestry Group -- psychology KW - Prognosis KW - Alcohol Drinking -- adverse effects KW - Sick Role KW - Aged KW - Outcome Assessment (Health Care) KW - African Continental Ancestry Group -- psychology KW - Alcohol Drinking -- epidemiology KW - Comorbidity KW - Socioeconomic Factors KW - Adult KW - Alcohol Drinking -- psychology KW - Middle Aged KW - Male KW - Female KW - Patient Compliance -- psychology KW - Antimanic Agents -- adverse effects KW - Veterans -- psychology KW - Anticonvulsants -- adverse effects KW - Anticonvulsants -- administration & dosage KW - Psychotic Disorders -- epidemiology KW - Cyclothymic Disorder -- epidemiology KW - Patient Compliance -- statistics & numerical data KW - Bipolar Disorder -- epidemiology KW - Veterans -- statistics & numerical data KW - Psychotic Disorders -- psychology KW - Psychotherapy KW - Antimanic Agents -- administration & dosage KW - Bipolar Disorder -- drug therapy KW - Cyclothymic Disorder -- drug therapy KW - Bipolar Disorder -- psychology KW - Cyclothymic Disorder -- psychology KW - Psychotic Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70211816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=Treatment+adherence+and+illness+insight+in+veterans+with+bipolar+disorder.&rft.au=Copeland%2C+Laurel+A%3BZeber%2C+John+E%3BSalloum%2C+Ihsan+M%3BPincus%2C+Harold+A%3BFine%2C+Michael+J%3BKilbourne%2C+Amy+M&rft.aulast=Copeland&rft.aufirst=Laurel&rft.date=2008-01-01&rft.volume=196&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=1539-736X&rft_id=info:doi/10.1097%2FNMD.0b013e318160ea00 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-29 N1 - Date created - 2008-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/NMD.0b013e318160ea00 ER - TY - JOUR T1 - Dose-related effects of the acetylcholinesterase inhibitor tacrine on cocaine and food self-administration in rats. AN - 70204169; 17917719 AB - Acetylcholine (ACh) is involved in brain reward and learning functions and contributes to opiate- and psychostimulant-motivated behaviors. Tacrine is a centrally acting, reversible cholinesterase inhibitor that also inhibits monoamine oxidase (MAO) and blocks reuptake of dopamine (DA) and serotonin. To determine the effects of pretreatment with tacrine on self-administration of cocaine and nondrug reinforcers. Male Wistar rats were trained to self-administer cocaine under a fixed-ratio-5 (FR-5) schedule during 2-h multiple-component sessions in which 0.1, 0.2, and 0.4 mg/kg per injection of cocaine were each available for 40 min. Other animals self-administered 45 mg food pellets under FR-30 or 20% Ensure (liquid food) under FR-5 in amounts of 30, 60, or 120 microl. Vehicle or tacrine was administered as single intravenous doses 20 min before self-administration of cocaine, food pellets, or liquid food. Although pretreatment with 0.032 mg/kg of tacrine increased self-administration of food pellets, pretreatment with higher doses of tacrine attenuated self-administration of cocaine, food pellets, or liquid food. Tacrine's ED50 value for attenuating self-administration of 0.1 mg/kg per injection of cocaine was more than sixfold lower than values for attenuating liquid food- or food pellet-reinforced behavior. However, ED50 values for attenuating self-administration of higher doses of cocaine were similar to those observed for 30 or 60 microl of liquid food. Tacrine can selectively attenuate self-administration of low-dose cocaine, but its effects on higher doses of cocaine are similar to its ability to decrease self-administration of nondrug reinforcers. JF - Psychopharmacology AU - Grasing, Kenneth AU - He, Shuangteng AU - Yang, Yungao AD - Kansas City VA Medical Center, Research Service, 151, 4801 Lindwood Boulevard, Kansas City, MO 64128, USA. kenneth.grasing@med.va.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 133 EP - 142 VL - 196 IS - 1 SN - 0033-3158, 0033-3158 KW - Cholinesterase Inhibitors KW - 0 KW - Tacrine KW - 4VX7YNB537 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Animals KW - Self Administration KW - Reinforcement Schedule KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Association Learning -- drug effects KW - Premedication KW - Rats, Wistar KW - Cues KW - Male KW - Cholinesterase Inhibitors -- pharmacology KW - Motivation KW - Cocaine-Related Disorders -- psychology KW - Tacrine -- pharmacology KW - Cocaine -- administration & dosage KW - Appetitive Behavior -- drug effects KW - Food Preferences -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70204169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Dose-related+effects+of+the+acetylcholinesterase+inhibitor+tacrine+on+cocaine+and+food+self-administration+in+rats.&rft.au=Grasing%2C+Kenneth%3BHe%2C+Shuangteng%3BYang%2C+Yungao&rft.aulast=Grasing&rft.aufirst=Kenneth&rft.date=2008-01-01&rft.volume=196&rft.issue=1&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-16 N1 - Date created - 2008-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The impact of depressive symptoms on alcohol and cigarette consumption following treatment for alcohol and nicotine dependence. AN - 70178660; 18076750 AB - Although depression is common among alcohol and tobacco dependent patients, its impact on treatment outcomes is not well established. The purpose of this study was to examine the impact of depressive symptoms on abstinence from tobacco and alcohol after treatment for alcohol dependence and nicotine dependence. The Timing of Alcohol and Smoking Cessation Study (TASC) randomized adults receiving intensive alcohol dependence treatment, who were also smokers, to concurrent or delayed smoking cessation treatment. The sample consisted of 462 adults who completed depression and substance use (alcohol and smoking) assessments at treatment entry and 6, 12, and 18 months posttreatment. Longitudinal regression models were used to examine the relationships between depression and subsequent abstinence from alcohol and tobacco after baseline characteristics, including alcohol and smoking histories, were considered. Depressive symptoms were prospectively related to nonabstinence from alcohol. Depressive symptoms at the previous assessment increased the odds of drinking at the subsequent time point by a factor of 1.67 (95% CI 1.14, 2.43), p < 0.01. Depressive symptoms were not significantly related to subsequent abstinence from cigarettes. Depression is an important negative predictor of the ability to maintain abstinence from alcohol within the context of intensive alcoholism and smoking treatment. It may be important to include depression-specific interventions for alcohol and tobacco dependent individuals to facilitate successful drinking treatment outcomes. JF - Alcoholism, clinical and experimental research AU - Kodl, Molly M AU - Fu, Steven S AU - Willenbring, Mark L AU - Gravely, Amy AU - Nelson, David B AU - Joseph, Anne Marie AD - Center for Chronic Disease Outcomes Research, Minneapolis VA Medical Center, Minneapolis, Minnesota 55417, USA. Molly.Kodl@va.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 92 EP - 99 VL - 32 IS - 1 KW - Index Medicus KW - Cross-Sectional Studies KW - Humans KW - Adult KW - Middle Aged KW - Longitudinal Studies KW - Time Factors KW - Male KW - Female KW - Tobacco Use Disorder -- therapy KW - Depression -- complications KW - Alcoholism -- therapy KW - Alcohol Drinking -- psychology KW - Tobacco Use Disorder -- psychology KW - Smoking -- psychology KW - Tobacco Use Disorder -- complications KW - Alcoholism -- psychology KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70178660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=The+impact+of+depressive+symptoms+on+alcohol+and+cigarette+consumption+following+treatment+for+alcohol+and+nicotine+dependence.&rft.au=Kodl%2C+Molly+M%3BFu%2C+Steven+S%3BWillenbring%2C+Mark+L%3BGravely%2C+Amy%3BNelson%2C+David+B%3BJoseph%2C+Anne+Marie&rft.aulast=Kodl&rft.aufirst=Molly&rft.date=2008-01-01&rft.volume=32&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=1530-0277&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-29 N1 - Date created - 2008-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension. AN - 70172052; 17984484 AB - The relative effectiveness of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) for lowering blood pressure is unknown. To compare the benefits and harms of ACE inhibitors versus ARBs for treating essential hypertension in adults. MEDLINE (1966 to May 2006), the Cochrane Central Register of Controlled Trials (Issue 2, 2006), and selected reference lists were searched for relevant English-language trials. The MEDLINE search was updated to August 2007 to identify head-to-head trials that reported blood pressure outcomes and major cardiovascular events. 61 clinical studies that directly compared ACE inhibitors versus ARBs in adult patients with essential hypertension, reported an outcome of interest, lasted at least 12 weeks, and included at least 20 patients. A standardized protocol with predefined criteria was used to extract data on study design, interventions, population characteristics, and outcomes; evaluate study quality and applicability; and assess the strength of the body of evidence for key outcomes. ACE inhibitors and ARBs had similar long-term effects on blood pressure (50 studies; strength of evidence, high). No consistent differential effects were observed for other outcomes (few studies reported long-term outcomes), including death, cardiovascular events, quality of life, rate of single antihypertensive agent use, lipid levels, progression to diabetes, left ventricular mass or function, and kidney disease. Consistent fair- to good-quality evidence showed that ACE inhibitors were associated with a greater risk for cough. There were fewer withdrawals due to adverse events and greater persistence with therapy for ARBs than for ACE inhibitors, although this evidence was not definitive. Patient subgroups for whom ACE inhibitors or ARBs were more effective, associated with fewer adverse events, or better tolerated were not identified. Few studies involved a representative sample treated in a typical clinical setting over a long duration, treatment protocols had marked heterogeneity, and substantive amounts of data about important outcomes and patient subgroups were missing. Available evidence shows that ACE inhibitors and ARBs have similar effects on blood pressure control, and that ACE inhibitors have higher rates of cough than ARBs. Data regarding other outcomes are limited. JF - Annals of internal medicine AU - Matchar, David B AU - McCrory, Douglas C AU - Orlando, Lori A AU - Patel, Manesh R AU - Patel, Uptal D AU - Patwardhan, Meenal B AU - Powers, Benjamin AU - Samsa, Gregory P AU - Gray, Rebecca N AD - Duke Center for Clinical Health Policy Research, Duke Clinical Research Institute, Duke University, and Durham U.S. Department of Veterans Affairs Medical Center, Durham, North Carolina 27705, USA. david.matchar@duke.edu Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 16 EP - 29 VL - 148 IS - 1 KW - Angiotensin II Type 1 Receptor Blockers KW - 0 KW - Angiotensin-Converting Enzyme Inhibitors KW - Antihypertensive Agents KW - Abridged Index Medicus KW - Index Medicus KW - Cardiovascular Diseases -- epidemiology KW - Risk Factors KW - Humans KW - Adult KW - Treatment Outcome KW - Quality of Life KW - Hypertension -- physiopathology KW - Angiotensin-Converting Enzyme Inhibitors -- therapeutic use KW - Antihypertensive Agents -- adverse effects KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Antihypertensive Agents -- therapeutic use KW - Angiotensin II Type 1 Receptor Blockers -- therapeutic use KW - Hypertension -- drug therapy KW - Angiotensin II Type 1 Receptor Blockers -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70172052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Systematic+review%3A+comparative+effectiveness+of+angiotensin-converting+enzyme+inhibitors+and+angiotensin+II+receptor+blockers+for+treating+essential+hypertension.&rft.au=Matchar%2C+David+B%3BMcCrory%2C+Douglas+C%3BOrlando%2C+Lori+A%3BPatel%2C+Manesh+R%3BPatel%2C+Uptal+D%3BPatwardhan%2C+Meenal+B%3BPowers%2C+Benjamin%3BSamsa%2C+Gregory+P%3BGray%2C+Rebecca+N&rft.aulast=Matchar&rft.aufirst=David&rft.date=2008-01-01&rft.volume=148&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-07 N1 - Date created - 2008-01-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Intern Med. 2008 Jan 1;148(1):76-7 [17984483] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapeutic use of botulinum toxin type A in treating neck and upper-back pain of myofascial origin: a pilot study. AN - 70164615; 18164334 AB - To determine the efficacy of botulinum toxin type A (BTX-A) in treating neck and upper-back pain of myofascial origin. A randomized, double-blind, placebo-controlled pilot study. Outpatient physical medicine and rehabilitation clinic of a university-affiliated tertiary hospital. A total of 29 subjects enrolled from among 45 screened patients. No subject withdrawal due to serious adverse events occurred. Subjects were evaluated at baseline, received a 1-time injection of either BTX-A (treatment group) or saline (control group), and were followed up at 2 weeks and at months 1, 2, 3, 4, and 6. Visual analog scale (VAS) for pain, the Neck Disability Index (NDI), and the Medical Outcome Study 36-Item Short-Form Health Survey (SF-36). Improvements in the VAS and NDI scores were seen in the treatment group but were not significant when compared with the controls. Statistically significant improvements for the treatment group were seen in the SF-36 bodily pain (at months 2 and 4) and mental health (at month 1) scales but not in the other scales, nor in the summary measures. No serious adverse events were reported. Trends toward improvements in VAS and NDI scores of the BTX-A group are encouraging, but they were possibly due to a placebo effect and were not statistically significant. The BTX-A subjects, at certain time points, showed statistically significant improvements in the bodily pain and mental health scales of the SF-36 compared with controls. Our study had limited power and population base, but the results could be used to properly power follow-up studies to further investigate this topic. JF - Archives of physical medicine and rehabilitation AU - Lew, Henry L AU - Lee, Eun Ha AU - Castaneda, Annabel AU - Klima, Roger AU - Date, Elaine AD - Physical Medicine and Rehabilitation Service, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA. henry.lew@va.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 75 EP - 80 VL - 89 IS - 1 KW - Neuromuscular Agents KW - 0 KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Abridged Index Medicus KW - Index Medicus KW - Health Status Indicators KW - Double-Blind Method KW - Humans KW - Treatment Outcome KW - Pain Measurement KW - Aged KW - Pilot Projects KW - Male KW - Female KW - Neck Pain -- drug therapy KW - Botulinum Toxins, Type A -- therapeutic use KW - Myofascial Pain Syndromes -- drug therapy KW - Neuromuscular Agents -- therapeutic use KW - Back Pain -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70164615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+physical+medicine+and+rehabilitation&rft.atitle=Therapeutic+use+of+botulinum+toxin+type+A+in+treating+neck+and+upper-back+pain+of+myofascial+origin%3A+a+pilot+study.&rft.au=Lew%2C+Henry+L%3BLee%2C+Eun+Ha%3BCastaneda%2C+Annabel%3BKlima%2C+Roger%3BDate%2C+Elaine&rft.aulast=Lew&rft.aufirst=Henry&rft.date=2008-01-01&rft.volume=89&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Archives+of+physical+medicine+and+rehabilitation&rft.issn=1532-821X&rft_id=info:doi/10.1016%2Fj.apmr.2007.08.133 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-04 N1 - Date created - 2007-12-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Phys Med Rehabil. 2008 Apr;89(4):792-3; author reply 793 [18374016] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.apmr.2007.08.133 ER - TY - JOUR T1 - Generation of MUC1-stimulated mononuclear cells using optimized conditions. AN - 70102386; 18021186 AB - Mucin is a glycoprotein found on the surface of cell membranes of adenocarcinomas. The purpose of these studies was to generate MUC1 multiple tandem repeat (VNTR)-stimulated mononuclear cells (M1SMC). We first determined the optimal conditions to influence the immune response. In these studies, peripheral blood mononuclear cells (PBMC), from patients with adenocarcinomas, were stimulated by different numbers of M1SMC stimulations, various concentrations of MUC1 peptide, washing of PBMC prior to stimulation and days in culture, to determine the optimal conditions to influence the immune response. The results of this study indicate that the mononuclear cells (MC) stimulated twice 1 week apart with MUC1 VNTR1 produced a greater specific killing of the breast cancer cell line MCF-7 than the 0, 1, 3 or 4 weekly stimulations. The optimal molarity for inducing cytotoxicity and cytokines (granulocyte macrophage colony-stimulating factor, gamma-interferon and interleukin-10) was 45 x 10(-8) M (1 microg/ml); except for tumour necrosis factor (TNF)-alpha which was 22 x 10(-8) M (0.5 microg/ml). The unwashed MC were superior to washing them with Ficoll-Hypaque. The optimal number of days in culture for cytotoxicity and cytokine production was after two stimulations (i.e. after day 7). Optimum conditions for generation of M1SMC identified in these studies were two stimulations with peptide, concentration of 45 x 10(-8) M (1 microg/ml) peptide, unwashed cells, and after two stimulations or after 8 days in culture. M1SMC were generated from multiple patients with breast cancer which lysed adenocarcinoma cells. JF - Scandinavian journal of immunology AU - Wright, S E AU - Khaznadar, R AU - Wang, Z AU - Quinlin, I S AU - Rewers-Felkins, K A AU - Phillips, C A AU - Patel, S AD - Amarillo Veterans Affairs Medical Center, Amarillo, TX 79106, USA. stephen.wright@med.va.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 24 EP - 29 VL - 67 IS - 1 KW - MUC1 protein, human KW - 0 KW - Mucin-1 KW - Index Medicus KW - Cells, Cultured KW - Humans KW - Molecular Sequence Data KW - Cytotoxicity Tests, Immunologic KW - Cell Line, Tumor KW - Amino Acid Sequence KW - Adenocarcinoma -- therapy KW - Adenocarcinoma -- immunology KW - Female KW - Mucin-1 -- genetics KW - Mucin-1 -- physiology KW - Lymphocyte Activation -- genetics KW - Leukocytes, Mononuclear -- transplantation KW - Lymphocyte Activation -- immunology KW - Mucin-1 -- toxicity KW - Leukocytes, Mononuclear -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70102386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+immunology&rft.atitle=Generation+of+MUC1-stimulated+mononuclear+cells+using+optimized+conditions.&rft.au=Wright%2C+S+E%3BKhaznadar%2C+R%3BWang%2C+Z%3BQuinlin%2C+I+S%3BRewers-Felkins%2C+K+A%3BPhillips%2C+C+A%3BPatel%2C+S&rft.aulast=Wright&rft.aufirst=S&rft.date=2008-01-01&rft.volume=67&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+immunology&rft.issn=1365-3083&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-28 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethnic differences in alcohol treatment outcomes and the effect of concurrent smoking cessation treatment. AN - 70097573; 17689205 AB - The Timing of Alcohol and Smoking Cessation (TASC) Study tested the optimal timing of smoking cessation treatment in an alcohol-dependent population. Previously reported results suggest that providing concurrent smoking cessation treatment adversely affects alcohol outcomes. The purpose of this analysis was to investigate whether there are ethnic differences in alcohol and tobacco outcomes among a diverse sample of alcohol-dependent smokers using data from the TASC trial in which 499 participants were randomized to either concurrent (during alcohol treatment) or delayed (6 months later) smoking intervention. This analysis focused on smokers of Caucasian (n=381) and African American (n=78) ethnicity. Alcohol outcomes included 6 months sustained alcohol abstinence rates and time to first use of alcohol post-treatment. Tobacco outcomes included 7-day point prevalence smoking abstinence. Random effects logistic regression analysis was used to investigate intervention group and ethnic differences in the longitudinally assessed alcohol outcomes. Alcohol abstinence outcomes were consistently worse in the concurrent group than the delayed group among Caucasians, but this was not the case for African Americans. No significant ethnic differences were observed in smoking cessation outcomes. Findings from this analysis suggest that concurrent smoking cessation treatment adversely affects alcohol outcomes for Caucasians but not necessarily for African Americans. JF - Drug and alcohol dependence AU - Fu, Steven S AU - Kodl, Molly AU - Willenbring, Mark AU - Nelson, David B AU - Nugent, Sean AU - Gravely, Amy A AU - Joseph, Anne M AD - Center for Chronic Disease Outcomes Research, a VA HSR&D Center of Excellence, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA. Steven.Fu@va.gov Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 61 EP - 68 VL - 92 IS - 1-3 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Smoking -- therapy KW - Regression Analysis KW - Humans KW - Mental Disorders -- epidemiology KW - Diagnosis, Dual (Psychiatry) KW - African Americans KW - Ethnic Groups KW - European Continental Ancestry Group KW - Adult KW - Treatment Outcome KW - Substance-Related Disorders -- complications KW - Middle Aged KW - Mental Disorders -- complications KW - Female KW - Male KW - Proportional Hazards Models KW - Alcoholism -- rehabilitation KW - Smoking Cessation -- psychology KW - Alcoholism -- psychology KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70097573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Ethnic+differences+in+alcohol+treatment+outcomes+and+the+effect+of+concurrent+smoking+cessation+treatment.&rft.au=Fu%2C+Steven+S%3BKodl%2C+Molly%3BWillenbring%2C+Mark%3BNelson%2C+David+B%3BNugent%2C+Sean%3BGravely%2C+Amy+A%3BJoseph%2C+Anne+M&rft.aulast=Fu&rft.aufirst=Steven&rft.date=2008-01-01&rft.volume=92&rft.issue=1-3&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-12-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Behav Med. 1997 Summer;19(3):213-9 [9603696] J Subst Abuse. 1996;8(4):431-43 [9058355] Addiction. 1998 Jun;93(6):877-87 [9744123] Ann Behav Med. 1999 Summer;21(3):244-50 [10626032] JAMA. 2000 Nov 22-29;284(20):2606-10 [11086367] J Stud Alcohol. 2001 Mar;62(2):211-20 [11327187] J Consult Clin Psychol. 2001 Apr;69(2):295-304 [11393606] J Subst Abuse Treat. 2001 Apr;20(3):233-8 [11516593] Oncogene. 2002 Oct 21;21(48):7326-40 [12379876] Alcohol Clin Exp Res. 2003 Jan;27(1):88-92 [12544011] J Stud Alcohol. 1998 Nov;59(6):659-68 [9811087] Addict Behav. 1998 Sep-Oct;23(5):669-83 [9768302] Recent Dev Alcohol. 2003;16:335-59 [12638645] Arch Gen Psychiatry. 2004 Nov;61(11):1107-15 [15520358] J Consult Clin Psychol. 2004 Dec;72(6):1144-56 [15612860] J Stud Alcohol. 2004 Nov;65(6):681-91 [15700504] Alcohol Health Res World. 1998;22(4):260-4 [15706752] Alcohol Res Health. 2000;24(4):225-32 [15986717] Drug Alcohol Depend. 2006 Apr 28;82(2):91-102 [16188401] Alcohol Clin Exp Res. 2003 Aug;27(8):1340-4 [12966335] J Addict Dis. 2003;22(4):87-107 [14723480] Am J Public Health. 1988 Sep;78(9):1187-9 [3407817] Br J Addict. 1991 Sep;86(9):1119-27 [1932883] Health Psychol. 1991;10(5):360-5 [1935872] Women Health. 1992;18(4):35-51 [1462601] Am J Public Health. 1993 Feb;83(2):220-6 [8427327] J Subst Abuse Treat. 1993 Mar-Apr;10(2):181-7 [8510192] J Subst Abuse Treat. 1993 Mar-Apr;10(2):189-95 [8510193] Addict Behav. 1993 Nov-Dec;18(6):635-44 [8178702] J Stud Alcohol. 1994 Jan;55(1):61-71 [8189728] J Stud Alcohol. 1995 Sep;56(5):558-65 [7475037] JAMA. 1996 Apr 10;275(14):1097-103 [8601929] Am J Public Health. 1996 Jul;86(7):985-90 [8669523] J Subst Abuse. 1995;7(3):331-44 [8749792] J Subst Abuse Treat. 1996 Mar-Apr;13(2):107-18 [8880668] J Pers Assess. 1996 Dec;67(3):588-97 [8991972] Subst Use Misuse. 1998 Aug;33(10):2021-47 [9744841] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deleterious outcomes after abrupt transition from insulin glargine to insulin detemir in patients with type 1 diabetes mellitus. AN - 69639260; 18840012 AB - Iowa Care (Iowa Medicaid), USA, switched insulin glargine to insulin detemir in subjects with diabetes mellitus without the approval of healthcare providers. This study set out to examine the impact of transition on parameters of diabetes management in type 1 diabetes. This was a retrospective review of the records of subjects with type 1 diabetes up to August 2007 in whom transition occurred. Subjects completing 6 months of insulin detemir therapy were included. Twenty-four subjects switching from insulin glargine to insuline detemir (group 1) fulfilled the duration with insulin detemir. Glycaemic control (glycosylated haemoglobin [HbA1c]), bodyweight, daily insulin dose (units), total and insulin glargine or insulin detemir and rapid-acting insulin aspart and hypoglycaemic events during the last 4 weeks, pre-switch and again at 6 months post-switch were assessed. Records of 21 age-matched subjects and continuing insulin glargine for 6 months (group 2) were examined. Subjects switched from insulin glargine to insulin detemir in the same daily dose. The daily doses of insulin detemir and aspart in group 1 were adjusted by telephone weekly based on blood glucose monitoring until stabilization occurred. Subjects were followed up in the outpatient clinic every 3 months. Subjects in group 1 changed to insulin detemir twice a day because of a significant rise in hypoglycaemia with the daily dose used once a day. Glycaemic control remained stable on continuing insulin glargine; HbA1c 7.6+/-0.3 to 7.8+/-0.3%, while it worsened on switching to insulin detemir; HbA1c 7.9+/-0.6 to 8.8+/-0.8 despite a higher daily dose; insulin detemir 46+/-9 U/day versus pre-switch insulin glargine 36+/-8 U/day and group 2 insulin glargine 35+/-6 U/day; and greater total insulin dose: 80+/-12 U/day versus 68+/-10 pre-switch and group 2 insulin glargine 62+/-10 U/day (p<0.05 for all comparisons). Bodyweight and hypoglycaemic events were not significantly different pre- and post-switch. Switching to insulin detemir from glargine is likely to result in lapse of glycaemic control despite a higher daily insulin dose, increased number of injections and need for frequent evaluations. JF - Clinical drug investigation AU - Kabadi, Udaya M AD - Department of Medicine, University of Iowa, Iowa City, Iowa, USA. udaya.kabadi@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 697 EP - 701 VL - 28 IS - 11 SN - 1173-2563, 1173-2563 KW - Blood Glucose KW - 0 KW - Hemoglobin A, Glycosylated KW - Hypoglycemic Agents KW - Insulin KW - Insulin, Long-Acting KW - hemoglobin A1c protein, human KW - Insulin Glargine KW - 2ZM8CX04RZ KW - Insulin Detemir KW - 4FT78T86XV KW - Index Medicus KW - United States KW - Drug Administration Schedule KW - Blood Glucose -- drug effects KW - Humans KW - Retrospective Studies KW - Medicaid KW - Iowa KW - Therapeutic Equivalency KW - Hemoglobin A, Glycosylated -- metabolism KW - Adult KW - Drug Monitoring KW - Treatment Outcome KW - Time Factors KW - Female KW - Male KW - Diabetes Mellitus, Type 1 -- drug therapy KW - Diabetes Mellitus, Type 1 -- blood KW - Insulin -- analogs & derivatives KW - Hypoglycemic Agents -- administration & dosage KW - Hypoglycemic Agents -- adverse effects KW - Hypoglycemia -- blood KW - Insulin -- administration & dosage KW - Hypoglycemia -- chemically induced KW - Hypoglycemic Agents -- pharmacokinetics KW - Insulin -- pharmacokinetics KW - Insulin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69639260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+drug+investigation&rft.atitle=Deleterious+outcomes+after+abrupt+transition+from+insulin+glargine+to+insulin+detemir+in+patients+with+type+1+diabetes+mellitus.&rft.au=Kabadi%2C+Udaya+M&rft.aulast=Kabadi&rft.aufirst=Udaya&rft.date=2008-01-01&rft.volume=28&rft.issue=11&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Clinical+drug+investigation&rft.issn=11732563&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-10-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hageseth's principle of extraterritorial jurisdiction and international telemedicine. AN - 69520469; 18776071 AB - At what point does an international telemedicine transaction create a sufficient commercial nexus to allow one country the authority to impose its laws on a foreign telemedicine providers? Some light on this matter was shed by the US case of Hageseth versus Superior Court. The authority for extraterritorial jurisdiction is found in the US Constitution, which requires the states to cooperate in matters of law enforcement. Similar cooperation from foreign nations cannot be expected. Unless a defendant is charged with a capital offence, nations are rarely willing to extradite their citizens. As the unlicensed practice of medicine is not a capital offence, it is unlikely that an unlicensed telemedicine provider would be extradited to the US. Because low-volume unlicensed offshore telemedicine providers are unlikely to be extradited or to be subject to trade sanctions, they may be able to operate beyond the law. JF - Journal of telemedicine and telecare AU - McLean, Thomas R AU - McLean, Alexander B AD - Eastern Kansas Health Care System, Surgical Service, 4101 S Fourth Street Trafficway, Leavenworth, Kansas 66048, USA. Thomas.McLean@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 282 EP - 284 VL - 14 IS - 6 KW - Fluoxetine KW - 01K63SUP8D KW - Index Medicus KW - United States KW - Internet -- legislation & jurisprudence KW - International Cooperation KW - Humans KW - Drug Overdose KW - Adult KW - Fluoxetine -- poisoning KW - Physician-Patient Relations KW - Male KW - Malpractice -- legislation & jurisprudence KW - Licensure, Medical -- legislation & jurisprudence KW - Telemedicine -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69520469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+telemedicine+and+telecare&rft.atitle=Hageseth%27s+principle+of+extraterritorial+jurisdiction+and+international+telemedicine.&rft.au=McLean%2C+Thomas+R%3BMcLean%2C+Alexander+B&rft.aulast=McLean&rft.aufirst=Thomas&rft.date=2008-01-01&rft.volume=14&rft.issue=6&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Journal+of+telemedicine+and+telecare&rft.issn=1758-1109&rft_id=info:doi/10.1258%2Fjtt.2008.080416 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-10 N1 - Date created - 2008-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1258/jtt.2008.080416 ER - TY - JOUR T1 - Opiates and elderly: use and side effects. AN - 69405794; 18686750 AB - The evaluation of pain and the subsequent issue of pain control is a clinical challenge that all healthcare providers face. Pain in the elderly population is especially difficult given the myriad of physiological, pharmacological, and psychological aspects of caring for the geriatric patient. Opiates are the mainstay of pain treatment throughout all age groups but special attention must be paid to the efficacy and side effects of these powerful drugs when prescribing to a population with impaired metabolism, excretion and physical reserve. In a random chart review of 300 US veterans, 44% of those receiving an analgesic also received opioids. The increasing use of opiates for pain management by healthcare practitioners requires that those prescribing opioids be aware of the special considerations for treating the elderly. This article will address the precautions one must take when using opiates in the geriatric population, as well as the side effects and ways to minimize them. JF - Clinical interventions in aging AU - Chau, Diane L AU - Walker, Vanessa AU - Pai, Latha AU - Cho, Lwin M AD - University of Nevada School of Medicine, Reno, NV, USA diane.chau@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 273 EP - 278 VL - 3 IS - 2 SN - 1176-9092, 1176-9092 KW - Analgesics, Opioid KW - 0 KW - Index Medicus KW - Metabolic Detoxication, Phase I -- physiology KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Pain -- drug therapy KW - Analgesics, Opioid -- pharmacokinetics KW - Analgesics, Opioid -- adverse effects KW - Analgesics, Opioid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69405794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+interventions+in+aging&rft.atitle=Opiates+and+elderly%3A+use+and+side+effects.&rft.au=Chau%2C+Diane+L%3BWalker%2C+Vanessa%3BPai%2C+Latha%3BCho%2C+Lwin+M&rft.aulast=Chau&rft.aufirst=Diane&rft.date=2008-01-01&rft.volume=3&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Clinical+interventions+in+aging&rft.issn=11769092&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-09 N1 - Date created - 2008-08-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2001 May 1;19(9):2542-54 [11331334] Consult Pharm. 2007 May;22(5):417-30 [17658959] J Pain Symptom Manage. 2002 Feb;23(2):131-7 [11844633] J Am Geriatr Soc. 2002 Jun;50(6 Suppl):S205-24 [12067390] Pharmacotherapy. 2003 Jun;23(6):802-5 [12820821] Am J Cardiol. 2003 Oct 15;92(8):995-7 [14556883] N Engl J Med. 2003 Nov 13;349(20):1943-53 [14614170] Am J Physiol Regul Integr Comp Physiol. 2003 Dec;285(6):R1274-5 [14615398] J Am Geriatr Soc. 2004 Jun;52(6):867-74 [15161448] Curr Med Res Opin. 2004 Jun;20(6):911-8 [15200750] Pain Manag Nurs. 2004 Jun;5(2):53-8 [15297951] Am J Psychiatry. 1980 Aug;137(8):909-15 [6774622] Pain. 1984 Jan;18(1):1-11 [6200818] Baillieres Clin Gastroenterol. 1988 Jan;2(1):123-39 [2838107] Br J Clin Pharmacol. 1991 Jun;31(6):635-42 [1867957] Clin Pharmacokinet. 1996 Dec;31(6):410-22 [8968655] Br J Clin Pharmacol. 1998 Dec;46(6):531-3 [9862240] Clin Pharmacokinet. 1999 Jul;37(1):17-40 [10451781] J Am Med Dir Assoc. 2005 Jan-Feb;6(1):10-7 [15871865] Pharmacotherapy. 2005 Oct;25(10):1396-430 [16185185] CMAJ. 2006 May 23;174(11):1589-94 [16717269] J Opioid Manag. 2005 Nov-Dec;1(5):244-8 [17319557] Clin Geriatr Med. 2007 May;23(2):371-90, vii [17462523] J Gerontol Nurs. 2002 Jan;28(1):20-7; quiz 54-5 [11829221] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Liver disease in injection drug users with hepatitis C, with and without HIV coinfection. AN - 69396725; 18681191 AB - Liver disease is a major health problem for individuals with a history of injection drug use. This is mainly from the hepatitis C virus (HCV), with or without co-infection with HIV. HCV-associated liver disease takes decades to develop into cirrhosis, from which it can adversely affect health. HIV coinfection is among the factors that are often associated with liver disease progression, and efforts to understand liver disease progression in HIV-HCV coinfected patients remain important. Maintaining high CD4 counts and avoiding alcohol intake are associated with slower liver disease progression. Pegylated interferon and ribavirin combination therapy has the potential to clear HCV, which provides the strongest health benefit to patients affected by the virus, although this can be difficult to accomplish for many reasons. Steatosis, fat within the liver, may also have important pathological implications for liver disease related to HCV. Limiting liver disease progression in IDUs with hepatitis C may well be best accomplished through promoting their full utilization of health care. JF - Journal of addictive diseases AU - Monto, Alexander AU - Currie, Sue AU - Wright, Teresa L AD - San Francisco Veterans Affairs Medical Center, CA, USA. Alexander.Monto@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 49 EP - 59 VL - 27 IS - 2 SN - 1055-0887, 1055-0887 KW - Index Medicus KW - Humans KW - Incidence KW - Comorbidity KW - Prevalence KW - Liver Cirrhosis -- diagnosis KW - Substance Abuse, Intravenous -- epidemiology KW - Liver Cirrhosis -- epidemiology KW - Hepatitis C -- epidemiology KW - HIV Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69396725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+addictive+diseases&rft.atitle=Liver+disease+in+injection+drug+users+with+hepatitis+C%2C+with+and+without+HIV+coinfection.&rft.au=Monto%2C+Alexander%3BCurrie%2C+Sue%3BWright%2C+Teresa+L&rft.aulast=Monto&rft.aufirst=Alexander&rft.date=2008-01-01&rft.volume=27&rft.issue=2&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Journal+of+addictive+diseases&rft.issn=10550887&rft_id=info:doi/10.1300%2FJ069v27n02_06 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-17 N1 - Date created - 2008-08-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1300/J069v27n02_06 ER - TY - JOUR T1 - Neurotoxin treatments for urinary incontinence in subjects with spinal cord injury or multiple sclerosis: a systematic review of effectiveness and adverse effects. AN - 69260838; 18581662 AB - The objective was to evaluate the effectiveness of neurotoxin treatments of urinary incontinence (UI) in individuals with spinal cord injury (SCI) or multiple sclerosis (MS). Studies were included if published in English, presented randomized adults with SCI or MS, and reported UI outcomes. Ten trials randomizing 288 subjects with SCI (43%), MS (52%), or other spinal conditions (5%) and UI refractory to oral antimuscarinics were included. The overall mean age was 41 years, and 46% were women. Study durations ranged from 1 to 18 months. Treatments included botulinum toxin-A (BTX-A, 2 trials) and 2 vanilloid compounds, capsaicin (6 trials) and resiniferatoxin (4 trials). BTX-A was superior to placebo and resiniferatoxin in reducing daily UI episodes, mainly in individuals with SCI, although significant reductions vs placebo were not evident throughout the study duration. There were 1.1 fewer daily UI episodes in the BTX-A 200 unit group vs 0.1 fewer for the placebo group at the final week 24 assessment. Capsaicin was generally superior to placebo. The weighted difference between capsaicin and placebo in a pooled analysis of 2 trials enrolling subjects with either paraplegia or tetraplegia (n = 32) was -3.8 daily UI episodes [95% Cl -4.7 to -2.9] after 30 days. Capsaicin was comparable to resiniferatoxin. Pelvic pain and facial flushing were associated with capsaicin. Neurotoxins may improve refractive UI in adults with SCI or MS, although trial results were inconsistent. Trials were small in size and relatively short in duration. Further studies are needed to determine the efficacy and tolerability of long-term application. JF - The journal of spinal cord medicine AU - MacDonald, Roderick AU - Monga, Manoj AU - Fink, Howard A AU - Wilt, Timothy J AD - Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, 55417, USA. roderick.macdonald@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 157 EP - 165 VL - 31 IS - 2 SN - 1079-0268, 1079-0268 KW - Neurotoxins KW - 0 KW - Index Medicus KW - Placebo Effect KW - Humans KW - Treatment Outcome KW - Sample Size KW - Male KW - Female KW - Clinical Trials as Topic -- statistics & numerical data KW - Urinary Incontinence -- physiopathology KW - Urinary Incontinence -- etiology KW - Urinary Bladder, Neurogenic -- etiology KW - Spinal Cord Injuries -- complications KW - Urinary Bladder, Neurogenic -- drug therapy KW - Multiple Sclerosis -- complications KW - Neurotoxins -- administration & dosage KW - Urinary Bladder, Neurogenic -- physiopathology KW - Neurotoxins -- adverse effects KW - Urinary Incontinence -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69260838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+spinal+cord+medicine&rft.atitle=Neurotoxin+treatments+for+urinary+incontinence+in+subjects+with+spinal+cord+injury+or+multiple+sclerosis%3A+a+systematic+review+of+effectiveness+and+adverse+effects.&rft.au=MacDonald%2C+Roderick%3BMonga%2C+Manoj%3BFink%2C+Howard+A%3BWilt%2C+Timothy+J&rft.aulast=MacDonald&rft.aufirst=Roderick&rft.date=2008-01-01&rft.volume=31&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=The+journal+of+spinal+cord+medicine&rft.issn=10790268&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-12 N1 - Date created - 2008-06-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurourol Urodyn. 1998;17(5):513-23 [9776014] Scand J Urol Nephrol. 1998 Sep;32(5):331-4 [9825395] Scand J Urol Nephrol. 1999 Apr;33(2):104-10 [10360450] J Urol. 1999 Jul;162(1):3-11 [10379728] Neurourol Urodyn. 2005;24(1):2-12 [15578628] Eur Urol. 2005 May;47(5):653-9 [15826758] J Urol. 2005 Jul;174(1):196-200 [15947626] Eur Urol. 2005 Jul;48(1):5-26 [15885877] Eur Urol. 2005 Oct;48(4):650-5 [15961217] BJU Int. 2006 Jul;98(1):77-82 [16831148] Eur Urol. 2006 Oct;50(4):684-709; discussion 709-10 [16934391] Neurourol Urodyn. 2006;25(7):752-7 [16986136] Ann Acad Med Singapore. 2007 Jan;36(1):11-7 [17285181] J Am Osteopath Assoc. 2000 Mar;100(3 Suppl):S9-12 [10763312] J Urol. 2000 Sep;164(3 Pt 1):692-7 [10953127] Spine (Phila Pa 1976). 2001 Dec 15;26(24 Suppl):S129-36 [11805620] J Urol. 2002 Apr;167(4):1710-4 [11912393] Spinal Cord. 2002 Nov;40(11):599-600 [12411968] Eur Urol. 2003 Aug;44(2):165-74 [12875934] BMJ. 2003 Sep 6;327(7414):557-60 [12958120] J Urol. 2004 Jan;171(1):251-5 [14665887] J Spinal Cord Med. 2003 Winter;26(4):358-63 [14992337] Eur Urol. 2004 Apr;45(4):510-5 [15041117] J Urol. 2004 Jul;172(1):240-3 [15201783] Control Clin Trials. 1986 Sep;7(3):177-88 [3802833] JAMA. 1995 Feb 1;273(5):408-12 [7823387] BMJ. 1994 Nov 12;309(6964):1286-91 [7718048] Urology. 1997 Dec;50(6A Suppl):18-22; discussion 23-4 [9426747] Spinal Cord. 1998 Feb;36(2):95-9 [9494998] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Septicemic arthritis with antibiotic resistance: a case study. AN - 66668901; 19174979 AB - This article demonstrates how rheumatoid arthritis can be confused with septicemic arthritis. Effective diagnosis and treatment depends on timely and effective confirmation of the cause for arthritis. In the future, if such a case were presented, actions must be taken as soon as the bacteremia has been confirmed since the organism is the primary cause of the inflammation and not rheumatoid arthritis. If this is done immediately, the patient's body will be more effective at fighting off nosocomial infections resulting in a better prognosis. JF - Clinical laboratory science : journal of the American Society for Medical Technology AU - Tang, Yun AU - Leclair, Susan J AU - Scarano, Frank J AD - West Roxbury VAMC, Laboratory Services, Department of Immunology, 1400 VFW Parkway, West Roxbury, MA 02132, USA. Yun.Tang@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 205 EP - 209 VL - 21 IS - 4 SN - 0894-959X, 0894-959X KW - Anti-Bacterial Agents KW - 0 KW - Anti-Inflammatory Agents KW - Nafcillin KW - 4CNZ27M7RV KW - Vancomycin KW - 6Q205EH1VU KW - Prednisone KW - VB0R961HZT KW - Health technology assessment KW - Anti-Bacterial Agents -- therapeutic use KW - Fatal Outcome KW - Vancomycin -- pharmacology KW - Prednisone -- therapeutic use KW - Humans KW - Anti-Inflammatory Agents -- adverse effects KW - Anti-Bacterial Agents -- pharmacology KW - Anti-Inflammatory Agents -- therapeutic use KW - Staphylococcal Infections -- microbiology KW - Staphylococcal Infections -- drug therapy KW - Prednisone -- adverse effects KW - Leukopenia -- chemically induced KW - Nafcillin -- pharmacology KW - Cross Infection -- microbiology KW - Middle Aged KW - Bacteremia -- complications KW - Nafcillin -- therapeutic use KW - Vancomycin -- therapeutic use KW - Male KW - Arthritis, Rheumatoid -- drug therapy KW - Escherichia coli Infections -- microbiology KW - Arthritis, Infectious -- microbiology KW - beta-Lactam Resistance KW - Escherichia coli -- drug effects KW - Arthritis, Infectious -- diagnosis KW - Escherichia coli Infections -- complications KW - Arthritis, Rheumatoid -- complications KW - Arthritis, Infectious -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66668901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+laboratory+science+%3A+journal+of+the+American+Society+for+Medical+Technology&rft.atitle=Septicemic+arthritis+with+antibiotic+resistance%3A+a+case+study.&rft.au=Tang%2C+Yun%3BLeclair%2C+Susan+J%3BScarano%2C+Frank+J&rft.aulast=Tang&rft.aufirst=Yun&rft.date=2008-01-01&rft.volume=21&rft.issue=4&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Clinical+laboratory+science+%3A+journal+of+the+American+Society+for+Medical+Technology&rft.issn=0894959X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2009-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Factor Analysis of the Trauma and Attachment Belief Scale: A Measure of Cognitive Schema Disruption Related to Traumatic Stress AN - 61348254; 200904448 AB - The factor structure of the Trauma and Attachment Belief Scale was examined using a large extant database (N = 2,407). The data were semirandomly split into 2 subsamples. An initial 3-factor solution was explored on the first subsample and replicated in the second subsample. Principle Axis Factoring with Varimax rotation revealed 3 stable factors that were largely replicated in the analysis of the second half of the data. These 3 factor solutions were examined, and 3 congruent subscales were derived. These subscales were named Self, Other, and Safety and are consistent with important aspects of Constructivist Self-Development Theory, in which the Trauma and Attachment Belief Scale is grounded. Clinical and research implications are discussed. Adapted from the source document. JF - Journal of Psychological Trauma AU - Varra, Edward M AU - Pearlman, Laurie Anne AU - Brock, Kathleen J AU - Hodgson, Sarah T AD - VA Puget Sound Health Care System, 1660 S. Columbian Way (116-MHC), Seattle, WA 98108 edward.varra@va.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 185 EP - 196 PB - Taylor & Francis, Philadelphia PA VL - 7 IS - 3 SN - 1932-2887, 1932-2887 KW - Traumatic stress, assessment, measurement, factor analysis, cognitive schema, constructivist self development theory KW - Measurement KW - Constructivism KW - Development KW - Trauma KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61348254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychological+Trauma&rft.atitle=Factor+Analysis+of+the+Trauma+and+Attachment+Belief+Scale%3A+A+Measure+of+Cognitive+Schema+Disruption+Related+to+Traumatic+Stress&rft.au=Varra%2C+Edward+M%3BPearlman%2C+Laurie+Anne%3BBrock%2C+Kathleen+J%3BHodgson%2C+Sarah+T&rft.aulast=Varra&rft.aufirst=Edward&rft.date=2008-01-01&rft.volume=7&rft.issue=3&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychological+Trauma&rft.issn=19322887&rft_id=info:doi/10.1080%2F19322880802266813 LA - English DB - Social Services Abstracts N1 - Date revised - 2009-06-01 N1 - Number of references - 33 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Trauma; Measurement; Development; Constructivism DO - http://dx.doi.org/10.1080/19322880802266813 ER - TY - JOUR T1 - Associations Between PTSD Symptoms and Parenting Satisfaction in a Female Veteran Sample AN - 61347889; 200904400 AB - The goal of this brief article is to examine the relationships between the posttraumatic stress disorder (PTSD) symptom clusters and parenting satisfaction in a sample of 60 female veterans of the Vietnam war who had biological children. Significant negative relationships were found between the avoidance/numbing and hyperarousal clusters of PTSD symptoms and parenting satisfaction. The association between hyperarousal and parenting satisfaction remained significant when each of the PTSD symptom clusters were examined together as predictors, and controlling for partner violence. Results suggest that higher levels of certain PTSD symptoms may adversely affect women's satisfaction in the parenting role. Adapted from the source document. JF - Journal of Psychological Trauma AU - Berz, Jennifer B AU - Taft, Casey T AU - Watkins, Laura E AU - Monson, Candice M AD - VA Boston Healthcare System (116B-2), 150 South Huntington Avenue, Boston, MA 02130 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 37 EP - 45 PB - Taylor & Francis, Philadelphia PA VL - 7 IS - 1 SN - 1932-2887, 1932-2887 KW - PTSD, parenting, veterans KW - Veterans KW - Satisfaction KW - Females KW - Childrearing Practices KW - Posttraumatic Stress Disorder KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61347889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychological+Trauma&rft.atitle=Associations+Between+PTSD+Symptoms+and+Parenting+Satisfaction+in+a+Female+Veteran+Sample&rft.au=Berz%2C+Jennifer+B%3BTaft%2C+Casey+T%3BWatkins%2C+Laura+E%3BMonson%2C+Candice+M&rft.aulast=Berz&rft.aufirst=Jennifer&rft.date=2008-01-01&rft.volume=7&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychological+Trauma&rft.issn=19322887&rft_id=info:doi/10.1080%2F19322880802125969 LA - English DB - Social Services Abstracts N1 - Date revised - 2009-06-01 N1 - Number of references - 22 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Childrearing Practices; Females; Satisfaction; Veterans DO - http://dx.doi.org/10.1080/19322880802125969 ER - TY - JOUR T1 - Self-Management of Chronic Disease: A Webliography AN - 57729372; 200903711 AB - Meeting the needs of people with chronic diseases is one of the major challenges facing U.S. health care today. Chronic disease is the leading cause of illness, disability, and death in the United States. It accounts for the majority of health care resources used each year and places substantial burdens on the quality of life of individuals, families, and communities. Successful chronic disease self-management is a partnership between an informed patient, the patient's family or caregiver, and the health professionals who care for the patient. Information available on the Internet can enable the patient to become an active partner in decision making and care. Adapted from the source document. JF - Journal of Consumer Health on the Internet AU - Taylor, Mary Virginia AU - Stephenson, Priscilla L AD - VA Medical Center at Memphis, 1030 Jefferson Avenue, Memphis, TN 38104 maryvirginia.taylor@va.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 349 EP - 360 PB - Taylor & Francis, Philadelphia PA VL - 12 IS - 4 SN - 1539-8285, 1539-8285 KW - Cancer, cardiovascular disease, chronic disease, diabetes, hypertension, respiratory diseases, self care KW - Web sites KW - Diseases KW - Consumer health information KW - article KW - 10.14: INFORMATION SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57729372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consumer+Health+on+the+Internet&rft.atitle=Self-Management+of+Chronic+Disease%3A+A+Webliography&rft.au=Taylor%2C+Mary+Virginia%3BStephenson%2C+Priscilla+L&rft.aulast=Taylor&rft.aufirst=Mary&rft.date=2008-01-01&rft.volume=12&rft.issue=4&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consumer+Health+on+the+Internet&rft.issn=15398285&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Consumer health information; Web sites; Diseases ER - TY - JOUR T1 - Identifying PTSD in primary care: Comparison of the Primary Care-PTSD Screen (PC-PTSD) and the General Health Questionnaire-12 (GHQ) AN - 57282926; 200907154 AB - The aim of this study was to compare the PC-PTSD and GHQ-12 in detecting new cases of PTSD among primary care patients. Data on the PC-PTSD, GHQ-12 and psychiatric diagnoses was extracted from clinical databases for 11,230 VA primary care patients. Signal detection analyses and likelihood ratios were used to compare screens. Logistic regression analysis was used to examine the prediction of PTSD by the PC-PTSD after controlling for the GHQ. The PC-PTSD had a higher positive predictive value than the GHQ (41 percent vs. 31 percent). Combining positive results on the two screens in predicting PTSD yielded the highest likelihood ratio (LR = 17.3) compared to a positive result on the PC-PTSD only (LR = 8.3) or the GHQ only (LR = 4.6). The PC-PTSD performed slightly better than the GHQ and provided unique information in identifying PTSD, suggesting that disorder specific screens are important to use in primary care settings. [Copyright Elsevier B.V.] JF - Journal of Anxiety Disorders AU - Ouimette, Paige AU - Wade, Michael AU - Prins, Annabel AU - Schohn, Mary AD - Center for Integrated Healthcare, Syracuse VA Medical Center & SUNY Upstate Medical University, United States Paigec.ouimette@med.va.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 337 EP - 343 PB - Elsevier Ltd, The Netherlands VL - 22 IS - 2 SN - 0887-6185, 0887-6185 KW - PTSD Primary care GHQ-12 Mental health screens KW - Screening KW - Posttraumatic stress disorder KW - Mental health KW - Primary health care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57282926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Anxiety+Disorders&rft.atitle=Identifying+PTSD+in+primary+care%3A+Comparison+of+the+Primary+Care-PTSD+Screen+%28PC-PTSD%29+and+the+General+Health+Questionnaire-12+%28GHQ%29&rft.au=Ouimette%2C+Paige%3BWade%2C+Michael%3BPrins%2C+Annabel%3BSchohn%2C+Mary&rft.aulast=Ouimette&rft.aufirst=Paige&rft.date=2008-01-01&rft.volume=22&rft.issue=2&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Journal+of+Anxiety+Disorders&rft.issn=08876185&rft_id=info:doi/10.1016%2Fj.janxdis.2007.02.010 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Primary health care; Screening; Mental health DO - http://dx.doi.org/10.1016/j.janxdis.2007.02.010 ER - TY - JOUR T1 - The Syndrome of Capgras AN - 57274935; 200907539 AB - The delusional belief that a close relative has been replaced by a look-alike impostor was named the Capgras delusion in honor of Joseph Capgras, who described the first case. Capgras's original patient, Mme M., had a complex mental illness with various symptoms in addition to the delusion of substitution. The focus in the literature has always been on her eponymous delusion, ignoring the rest of her condition. However, studying the substitution delusion in isolation from the rest of her illness has led to inadequate conclusions. It is necessary to understand the delusion within the broad context of her illness. Toward that goal, her mental illness is described here in detail. A particular pattern of delusions and illness is identified. This same pattern is noted in other cases of Capgras in the literature. Three new cases are reported here, each with the same overall pattern of illness that Mme M. had. This pattern is labeled the Syndrome of Capgras. A hypothesis is offered to explain the Capgras delusion within the context of this illness. Adapted from the source document. JF - Psychiatry AU - Sinkman, Arthur AD - 295 Central Park West, New York, NY 10024 Arthur.Sinkman@med.va.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 371 EP - 378 PB - The Guilford Press VL - 71 IS - 4 SN - 0033-2747, 0033-2747 KW - Capgras syndrome KW - Mental illness KW - Delusions KW - Isolation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57274935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry&rft.atitle=The+Syndrome+of+Capgras&rft.au=Sinkman%2C+Arthur&rft.aulast=Sinkman&rft.aufirst=Arthur&rft.date=2008-01-01&rft.volume=71&rft.issue=4&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Psychiatry&rft.issn=00332747&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - PSYCAB N1 - SubjectsTermNotLitGenreText - Delusions; Mental illness; Isolation; Capgras syndrome ER - TY - JOUR T1 - Disabilities and Health AN - 57264765; 200900329 AB - In the first 10 years of my nursing practice with the Department of Veterans Affairs I was unsympathetic to Vietnam Veterans who were diagnosed with post-traumatic stress disorder. My reluctance to try to understand these veterans was not unique. This essay presents the narrative of my coming to understand and to appreciate the depth of trauma that many Vietnam Veterans experienced during their tour of duty and the lingering effects of guilt that they hold over their participation in brutality. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Religion, Disability & Health AU - Grassman, Deborah AD - Bay Pines VA Healthcare System, 10000 Bay Pines Blvd., Bay Pines, FL, 33744 deborah.grassman@med.va.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 221 EP - 228 PB - Haworth Press, Binghamton NY VL - 12 IS - 3 SN - 1522-8967, 1522-8967 KW - Vietnam Veterans, guilt, trauma, post-traumatic stress disorder, wounded warrior KW - Psychological trauma KW - Veterans KW - Posttraumatic stress disorder KW - Guilt KW - Violence KW - Vietnam KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57264765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Religion%2C+Disability+%26+Health&rft.atitle=Disabilities+and+Health&rft.au=Grassman%2C+Deborah&rft.aulast=Grassman&rft.aufirst=Deborah&rft.date=2008-01-01&rft.volume=12&rft.issue=3&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Journal+of+Religion%2C+Disability+%26+Health&rft.issn=15228967&rft_id=info:doi/10.1080%2F15228960802269323 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-01-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Veterans; Vietnam; Psychological trauma; Violence; Guilt; Posttraumatic stress disorder DO - http://dx.doi.org/10.1080/15228960802269323 ER - TY - JOUR T1 - Regression to the mean in substance use disorder treatment research AN - 57259126; 200908873 AB - Aims Regression to the mean (RTM) refers to the tendency for a group of cases that differ from the population mean to move (regress) towards the mean, on average, when re-assessed, if scores at the two points are less than perfectly correlated. This paper considers factors that affect the magnitude of RTM and how RTM may impact findings from primary studies and reviews of substance use disorder (SUD) treatment. Design and methods The paper is guided largely by A Primer on Regression Artifacts by Campbell and Kenny. It reviews potential RTM effects in three areas of SUD treatment research. One is the extent to which within-group improvement in comparative treatment trials, including 'placebo effects', is a function of RTM. The second is the vulnerability of treatment evaluations employing non-equivalent control group designs to RTM and biased estimates of treatment effects when matching, or statistical equating is used to adjust for pre-existing group differences. The final issue is the impact of RTM in syntheses of research findings on SUD treatments. In particular, the tendency for later studies of a particular intervention to have smaller treatment effect sizes relative to earlier studies is considered as an RTM phenomenon. Findings RTM is a pervasive, but often unrecognized phenomenon that can bias findings in SUD treatment studies and in systematic reviews of that research. Conclusion SUD treatment researchers should be aware of RTM, take any available steps to reduce it, and try to diagnose whether it is still affecting research findings. Submitted 24 October 2006; initial review completed 2 May 2007; final version accepted 14 August 2007. Adapted from the source document. JF - Addiction AU - Finney, John W Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 42 EP - 52 PB - Blackwell Publishing, Oxford UK VL - 103 IS - 1 SN - 0965-2140, 0965-2140 KW - Measurement KW - Statistics KW - Substance abuse disorders KW - Placebo effect KW - Treatment KW - Methodology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57259126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Regression+to+the+mean+in+substance+use+disorder+treatment+research&rft.au=Finney%2C+John+W&rft.aulast=Finney&rft.aufirst=John&rft.date=2008-01-01&rft.volume=103&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.02032.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Treatment; Methodology; Substance abuse disorders; Measurement; Placebo effect; Statistics DO - http://dx.doi.org/10.1111/j.1360-0443.2007.02032.x ER - TY - JOUR T1 - Commentary on "Does Psychoeducation Help Prevent Posttraumatic Psychological Distress?": Wanted: A Theory of Post-Trauma Information Delivery AN - 57258269; 200907415 AB - As fields mature, they gradually map out their conceptual terrain, and different parts of the problem space are described and examined. As the field of traumatic stress has developed, attention has gradually turned toward the possibility of intervening soon after traumatic stress exposure to prevent development of problems. Researchers have started by evaluating the impact of the primary early intervention in current practice, stress debriefing. In that case, empirical investigation has indicated that stress debriefing does not prevent development of PTSD and depression symptoms. Moreover a few findings have suggested that the intervention may potentially worsen distress and symptoms. As empirical research in early intervention continues to develop, there will be increasing scrutiny of all components of helping efforts. This paper continues this healthy development trajectory by drawing attention to one key element of early intervention (and treatment of chronic PTSD) that has been previously accepted with relatively little scrutiny: psychoeducation. Adapted from the source document. JF - Psychiatry AU - Ruzek, Josef I AD - Dissemination and Training Division, National Center for PTSD, VA Palo Alto Health Care System, 795 Willow Road, Menlo Park, CA 94025 Ruzek@va.gov Josef. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 332 EP - 338 PB - The Guilford Press VL - 71 IS - 4 SN - 0033-2747, 0033-2747 KW - Symptoms KW - Posttraumatic stress disorder KW - Early intervention programmes KW - Psychoeducational treatment KW - Traumatic stress KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57258269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry&rft.atitle=Commentary+on+%22Does+Psychoeducation+Help+Prevent+Posttraumatic+Psychological+Distress%3F%22%3A+Wanted%3A+A+Theory+of+Post-Trauma+Information+Delivery&rft.au=Ruzek%2C+Josef+I&rft.aulast=Ruzek&rft.aufirst=Josef&rft.date=2008-01-01&rft.volume=71&rft.issue=4&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Psychiatry&rft.issn=00332747&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - PSYCAB N1 - SubjectsTermNotLitGenreText - Early intervention programmes; Symptoms; Traumatic stress; Posttraumatic stress disorder; Psychoeducational treatment ER - TY - JOUR T1 - Commentary on Does Psychoeducation Help Prevent Post Traumatic Psychological Distress? : Does Psychoedcation Help Prevent Post Traumatic Psychological Stress Disorder? In Reply AN - 57256009; 200907582 AB - Psychoeducation has become a widely used but poorly studied intervention field of traumatic stress. In their article, "Does Psychoeducation Help Prevent Post Traumatic Psychological Distress?" Wessley and colleagues discuss evidence for and against psychoeducation as a tool for preventing acute PTSD. Although we agree that psychoeducation is an important area investigation that needs to be evaluated using rigorous research methodologies, we are concerned about the way in which the authors have framed this issue. Adapted from the source document. JF - Psychiatry AU - Southwick, Steven AU - Friedman, Matthew AU - Krystal, John AD - Clinical Neurosciences Division, VA National Center for PTSD (116-A), VA Connecticut Healthcare System, West Haven, CT 06516 Steven.southwick@med.va.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 303 EP - 307 PB - The Guilford Press VL - 71 IS - 4 SN - 0033-2747, 0033-2747 KW - Posttraumatic stress disorder KW - Psychological distress KW - Psychoeducational treatment KW - Traumatic stress KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57256009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry&rft.atitle=Commentary+on+Does+Psychoeducation+Help+Prevent+Post+Traumatic+Psychological+Distress%3F+%3A+Does+Psychoedcation+Help+Prevent+Post+Traumatic+Psychological+Stress+Disorder%3F+In+Reply&rft.au=Southwick%2C+Steven%3BFriedman%2C+Matthew%3BKrystal%2C+John&rft.aulast=Southwick&rft.aufirst=Steven&rft.date=2008-01-01&rft.volume=71&rft.issue=4&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Psychiatry&rft.issn=00332747&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - PSYCAB N1 - SubjectsTermNotLitGenreText - Psychological distress; Psychoeducational treatment; Traumatic stress; Posttraumatic stress disorder ER - TY - JOUR T1 - VA telemental health: Suicide assessment AN - 57254550; 200821574 AB - The Department of Veterans Affairs (VA) encompasses one of the largest telemental health networks in the world, with over 45,000 videoconferencing and over 5,000 home telemental health encounters annually. Recently, the VA designated suicide prevention as a major priority, with telehealth modalities providing opportunities for remote interventions. Suicide risk assessments, using videoconferencing, are now documented in the literature, as are current studies that find telemental health to be equivalent to face-to-face treatment. Remote assessment of suicidality, however, involves complex legal issues: licensing requirements for remote delivery of care, legal procedures for involuntary detainment and commitment of potentially harmful patients, and liability questions related to the remote nature of the mental health service. VA best practices for remote suicide risk assessment include paradigms for establishing procedures in the context of legal challenges (licensing and involuntary detainment/commitment), for utilizing clinical assessment and triage decision protocols, and for contingency planning to optimize patient care and reduce liability. Published in 2008 by John Wiley & Sons, Ltd. [Copyright 2008 John Wiley and Sons, Ltd.] JF - Behavioral Sciences & the Law AU - Godleski, Linda AU - Nieves, J Edwin AU - Darkins, Adam AU - Lehmann, Laurent AD - Yale School of Medicine, VA Connecticut Healthcare System, 950 Campbell Avenue 11-D, West Haven, CT 06516, U.S.A linda.godleski2@va.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 271 EP - 286 PB - John Wiley & Sons, Chichester UK VL - 26 IS - 3 SN - 0735-3936, 0735-3936 KW - Risk assessment KW - Veterans KW - USA KW - Mental health care KW - Videoconferencing KW - Suicide KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57254550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sciences+%26+the+Law&rft.atitle=VA+telemental+health%3A+Suicide+assessment&rft.au=Godleski%2C+Linda%3BNieves%2C+J+Edwin%3BDarkins%2C+Adam%3BLehmann%2C+Laurent&rft.aulast=Godleski&rft.aufirst=Linda&rft.date=2008-01-01&rft.volume=26&rft.issue=3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sciences+%26+the+Law&rft.issn=07353936&rft_id=info:doi/10.1002%2Fbsl.811 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - BSLADR N1 - SubjectsTermNotLitGenreText - USA; Veterans; Mental health care; Suicide; Risk assessment; Videoconferencing DO - http://dx.doi.org/10.1002/bsl.811 ER - TY - JOUR T1 - Problem-free drinking over 16 years among individuals with alcohol use disorders AN - 57243385; 200811826 AB - Background Limited data exist on the rates and long-term stability of non-problem drinking in individuals who sought help for an alcohol use disorder. Methods A sample of initially untreated individuals with alcohol use disorders (n=420) was surveyed at baseline and 1 year and was re-assessed at 8 and 16 years. Results In the 6 months prior to the 1-year assessment, 36% (n=152) of participants reported abstinence from alcohol, 48% (n=200) reported drinking with problems, and 16% (n=68) reported non-problem drinking. At each follow up, 16-21% of the sample reported non-problem drinking. Compared to individuals in the abstinent and problem-drinking groups, individuals who were drinking in a problem-free manner at 1 year had reported, at baseline, fewer days of intoxication, drinks per drinking day, alcohol dependence symptoms, and alcohol-related problems, less depression, and more adaptive coping mechanisms. Over time, 48% of participants who engaged in non-problem drinking at 1 year continued to report positive outcomes (either non-problem drinking or abstinence) throughout the long-term follow-up, whereas 77% of those abstaining at 1 year reported positive outcomes throughout the same time period. Additionally, 43% of individuals with problematic alcohol consumption at 1 year reported positive outcomes over the remaining follow-up interval, a rate that was not significantly different from the rate of positive outcomes of 48% observed in those with initial problem-free drinking. Conclusions Although some individuals report non-problem drinking a year after initially seeking help, this pattern of alcohol use is relatively infrequent and is less stable over time than is abstinence. An accurate understanding of the long-term course of alcohol use and problems could help shape expectations about the realistic probability of positive outcomes for individuals considering moderate drinking as a treatment goal. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Ilgen, Mark A AU - Wilbourne, Paula L AU - Moos, Bernice S AU - Moos, Rudolf H AD - Center for Health Care Evaluation, Department of Veterans Affairs Palo Alto Health Care System and Stanford University School of Medicine, 795 Willow Road (MPD 152), Menlo Park, CA 94025, USA mark.ilgen@va.gov Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 116 EP - 122 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 92 IS - 1-3 SN - 0376-8716, 0376-8716 KW - Alcohol KW - Treatment KW - Abstinence KW - Moderation KW - Recovery KW - Alcohol consumption KW - Alcohol related disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57243385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Problem-free+drinking+over+16+years+among+individuals+with+alcohol+use+disorders&rft.au=Ilgen%2C+Mark+A%3BWilbourne%2C+Paula+L%3BMoos%2C+Bernice+S%3BMoos%2C+Rudolf+H&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2008-01-01&rft.volume=92&rft.issue=1-3&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.07.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Alcohol related disorders; Alcohol consumption; Abstinence; Recovery; Moderation DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.07.006 ER - TY - JOUR T1 - Successful Use of Linezolid in the Treatment of Enterococcal Endocarditis: an Effective and Safe Option? AN - 21116026; 8567240 JF - Clinical Microbiology Newsletter AU - Javaid, Maria AU - Abdelhamed, Abdelhamed AU - Samar, Huma AU - Cynamon, Michael AD - Division of Cardiology, Department of Medicine, SUNY Upstate Medical University, Syracuse, New York, Michael.Cynamon@med.va.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 5 EP - 6 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 30 IS - 1 SN - 0196-4399, 0196-4399 KW - Microbiology Abstracts B: Bacteriology KW - Linezolid KW - Endocarditis KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21116026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Newsletter&rft.atitle=Successful+Use+of+Linezolid+in+the+Treatment+of+Enterococcal+Endocarditis%3A+an+Effective+and+Safe+Option%3F&rft.au=Javaid%2C+Maria%3BAbdelhamed%2C+Abdelhamed%3BSamar%2C+Huma%3BCynamon%2C+Michael&rft.aulast=Javaid&rft.aufirst=Maria&rft.date=2008-01-01&rft.volume=30&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Newsletter&rft.issn=01964399&rft_id=info:doi/10.1016%2Fj.clinmicnews.2007.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Linezolid; Endocarditis DO - http://dx.doi.org/10.1016/j.clinmicnews.2007.12.002 ER - TY - JOUR T1 - Decision-making in percutaneous coronary intervention: a survey AN - 21029501; 8520084 AB - Background Few researchers have examined the perceptions of physicians referring cases for angiography regarding the degree to which collaboration occurs during percutaneous coronary intervention (PCI) decision-making. We sought to determine perceptions of physicians concerning their involvement in PCI decisions in cases they had referred to the cardiac catheterization laboratory at a major academic medical center. Methods An anonymous survey was mailed to internal medicine faculty members at a major academic medical center. The survey elicited whether responders perceived that they were included in decision-making regarding PCI, and whether they considered such collaboration to be the best process of decision-making. Results Of the 378 surveys mailed, 35% (133) were returned. Among responding non-cardiologists, 89% indicated that in most cases, PCI decisions were made solely by the interventionalist at the time of the angiogram. Among cardiologists, 92% indicated that they discussed the findings with the interventionalist prior to any PCI decisions. When asked what they considered the best process by which PCI decisions are made, 66% of non-cardiologists answered that they would prefer collaboration between either themselves or a non-interventional cardiologist and the interventionalist. Among cardiologists, 95% agreed that a collaborative approach is best. Conclusion Both non-cardiologists and cardiologists felt that involving another decision-maker, either the referring physician or a non-interventional cardiologist, would be the best way to make PCI decisions. Among cardiologists, there was more concordance between what they believed was the best process for making decisions regarding PCI and what they perceived to be the actual process. JF - BMC Medical Informatics and Decision Making AU - Rahilly-Tierney, Catherine R AU - Nash, Ira S AD - Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC), Boston VA Healthcare System, Boston, Massachusetts, USA, Catherine.Rahilly@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 28 PB - BioMed Central Ltd., Middlesex House VL - 8 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Decision making KW - Catheterization KW - Angiography KW - Perception KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21029501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Medical+Informatics+and+Decision+Making&rft.atitle=Decision-making+in+percutaneous+coronary+intervention%3A+a+survey&rft.au=Rahilly-Tierney%2C+Catherine+R%3BNash%2C+Ira+S&rft.aulast=Rahilly-Tierney&rft.aufirst=Catherine&rft.date=2008-01-01&rft.volume=8&rft.issue=&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=BMC+Medical+Informatics+and+Decision+Making&rft.issn=1472-6947&rft_id=info:doi/10.1186%2F1472-6947-8-28 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Decision making; Perception; Angiography; Catheterization; Heart DO - http://dx.doi.org/10.1186/1472-6947-8-28 ER - TY - JOUR T1 - Kinetic mechanisms to alter walking speed AN - 20971540; 8567548 AB - A mechanism to modulate speed during human walking has not yet been proposed in the literature, even though changing walking speed is likely a necessary attribute of everyday ambulation. To understand how joint kinetics modulate walking speed 12 normal adults walked Fast (1.4 m/s), Slow (1.0 m/s), Accel (1.0-1.4 m/s) and Decel (1.4-1.0 m/s) trials while full body 3D kinematics and kinetics were collected. Reduced sagittal ankle plantarflexor moments were observed in Accel trials during early single limb stance (p < 0.001) and increased sagittal plantarflexor moments were seen in Decel trials during early single limb stance (p < 0.001) compared to steady speed walking. Modulating the sagittal ankle moment altered the center of pressure location and either attenuated (Accel) or accentuated (Decel) the early stance braking impulse to accelerate or decelerate the center of mass. The onset of walking speed changes occurred at [not, vert, similar]15% of the gait cycle and did not support the concept of "controlled falling". Sagittal ankle push-off power appears a consequence of increased walking speed, but not the causative factor to increase walking speed. JF - Gait & Posture AU - Orendurff, Michael S AU - Bernatz, Greta C AU - Schoen, Jason A AU - Klute, Glenn K AD - Motion Analysis Laboratory, Center of Excellence for Limb Loss Prevention and Prosthetic Engineering, Rehabilitation Research and Development, Veterans Administration Puget Sound Health Care System, Seattle, WA, USA, morendurff@hotmail.com Y1 - 2008 PY - 2008 DA - 2008 SP - 603 EP - 610 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 27 IS - 4 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Kinematics KW - Speed KW - Kinetics KW - Ankles KW - Falling KW - Walking KW - Center of gravity KW - Gait KW - Joints KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20971540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=Kinetic+mechanisms+to+alter+walking+speed&rft.au=Orendurff%2C+Michael+S%3BBernatz%2C+Greta+C%3BSchoen%2C+Jason+A%3BKlute%2C+Glenn+K&rft.aulast=Orendurff&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=27&rft.issue=4&rft.spage=603&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2007.08.004 LA - English DB - Physical Education Index N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Speed; Walking; Kinetics; Ankles; Gait; Center of gravity; Falling; Joints; Kinematics DO - http://dx.doi.org/10.1016/j.gaitpost.2007.08.004 ER - TY - JOUR T1 - Relationship between T Cell Activation and CD4 super(+) T Cell Count in HIV-Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy AN - 20951854; 8452177 AB - Background. Although untreated human immunodeficiency virus (HIV)-infected patients maintaining undetectable plasma HIV RNA levels (elite controllers) have high HIV-specific immune responses, It is unclear whether they experience abnormal levels of T cell activation, potentially contributing to immunodeficiency. Methods. We compared percentages of activated (CD38 super(+)HLA-DR super(+)) T cells between 30 elite controllers, 47 HIV-uninfected individuals, 187 HIV-infected individuals with undetectable viremia receiving antiretroviral therapy (antiretroviral therapy suppressed), and 66 untreated HIV-infected individuals with detectable viremia. Because mucosal translocation of bacterial products may contribute to T cell activation in HIV infection, we also measured plasma lipopolysaccharide (LPS) levels. Results. Although the median CD4 super(+) cell count in controllers was 727 cells/mm super(3), 3 (10%) had CD4 super(+) cell counts <350 cells/mm super(3) and 2 (7%) had acquired immunodeficiency syndrome. Controllers had higher CD4 super(+) and CD8 super(+) cell activation levels (P < .001 for both) than HIV-negative subjects and higher CD8 super(+) cell activation levels than the antiretroviral therapy suppressed (P = 0.048). In controllers, higher CD4 super(+) and CD8 super(+) T cell activation was associated with lower CD4 super(+) cell counts (P = .009 and P = .047). Controllers had higher LPS levels than HIV-negative subjects (P < .001), and in controllers higher LPS level was associated with higher CD8 super(+) T cell activation (P = .039). Conclusion. HIV controllers have abnormally high T cell activation levels, which may contribute to progressive CD4 super(+) T cell toss even without measurable viremia. JF - Journal of Infectious Diseases AU - Hunt, P W AU - Brenchley, J AU - Sinclair, E AU - McCune, J M AU - Roland, M AU - Pags-Shafer, K AU - Hsue, P AU - Emu, B AU - Krone, M AU - Lampiris, H AU - Douek, D AU - Martin, J N AU - Deeks, S G AD - Positive Health Program and Division of Cardiology, San Francisco General Hospital, Division of Experimental Medicine, Department of Madicine, Center for AIDS Prevention Studies, Department of Epidemiology and Biostatistics, and San Francisco Veterans Administration Medical Center, University of California, San Francisco, USA Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 126 EP - 133 VL - 197 IS - 1 SN - 0022-1899, 0022-1899 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts KW - antiretroviral therapy KW - Mucosa KW - Immunodeficiency KW - CD8 antigen KW - Infection KW - Cell activation KW - CD4 antigen KW - RNA KW - Human immunodeficiency virus KW - Lymphocytes T KW - Lipopolysaccharides KW - Viremia KW - Translocation KW - V 22360:AIDS and HIV KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20951854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Relationship+between+T+Cell+Activation+and+CD4+super%28%2B%29+T+Cell+Count+in+HIV-Seropositive+Individuals+with+Undetectable+Plasma+HIV+RNA+Levels+in+the+Absence+of+Therapy&rft.au=Hunt%2C+P+W%3BBrenchley%2C+J%3BSinclair%2C+E%3BMcCune%2C+J+M%3BRoland%2C+M%3BPags-Shafer%2C+K%3BHsue%2C+P%3BEmu%2C+B%3BKrone%2C+M%3BLampiris%2C+H%3BDouek%2C+D%3BMartin%2C+J+N%3BDeeks%2C+S+G&rft.aulast=Hunt&rft.aufirst=P&rft.date=2008-01-01&rft.volume=197&rft.issue=1&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F524143 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - CD4 antigen; RNA; Mucosa; antiretroviral therapy; Immunodeficiency; Lymphocytes T; Lipopolysaccharides; Viremia; CD8 antigen; Infection; Translocation; Cell activation; Human immunodeficiency virus DO - http://dx.doi.org/10.1086/524143 ER - TY - JOUR T1 - Evaluation of psychometric properties of Walking Impairment Questionnaire in overweight patients with osteoarthritis of knee AN - 20882695; 8402062 AB - This study tested the psychometric properties of the Walking Impairment Questionnaire (WIQ) in overweight patients with osteoarthritis (OA) of the knee. Internal consistency, test-retest reliability, and concurrent validity of the WIQ were measured. Used in a randomized clinical trial, the WIQ was one of the instruments completed by overweight adults with OA of the knee. A total of 105 patients completed the WIQ. Internal consistency of the WIQ was supported in this population with a Cronbach alpha total score of 0.97. Test-retest reliability scores were not different when subjects completed the WIQ 14 days apart (p > 0.05). The relationships were moderate between the WIQ subscales and other established measures, such as the 6-minute walk distance, stair climb and descend, and the Western Ontario and McMaster Universities (OA Index) questionnaire. After evaluating the psychometric properties of the WIQ, we found that it is a valid and reliable instrument to use in overweight patients with symptomatic OA of the knee. JF - Journal of Rehabilitation Research and Development AU - Collins, E AU - O'Connell, S AU - Jelinek, C AU - Miskevics, S AU - Budiman-Mak, E AD - Research & Development (151), Edward Hines Jr VA Hospital, Hines, IL 60141, USA, eileen.collins@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 559 EP - 566 VL - 45 IS - 4 SN - 0748-7711, 0748-7711 KW - Physical Education Index KW - Evaluation KW - Obesity KW - Arthritis KW - Reliability KW - Validity KW - Knees KW - Walking KW - Surveys KW - Patients KW - PE 110:Physical Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20882695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Evaluation+of+psychometric+properties+of+Walking+Impairment+Questionnaire+in+overweight+patients+with+osteoarthritis+of+knee&rft.au=Collins%2C+E%3BO%27Connell%2C+S%3BJelinek%2C+C%3BMiskevics%2C+S%3BBudiman-Mak%2C+E&rft.aulast=Collins&rft.aufirst=E&rft.date=2008-01-01&rft.volume=45&rft.issue=4&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2007.04.0053 LA - English DB - Physical Education Index N1 - Date revised - 2008-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obesity; Knees; Patients; Surveys; Reliability; Walking; Arthritis; Evaluation; Validity DO - http://dx.doi.org/10.1682/JRRD.2007.04.0053 ER - TY - JOUR T1 - Structural equation modeling of associations among combat exposure, PTSD symptom factors, and Global Assessment of Functioning AN - 20860343; 8369561 AB - This study used structural equation modeling (SEM) to evaluate the relative strength of associations between combat exposure, four posttraumatic stress disorder (PTSD) symptom factors, and functional impairment as indexed by Global Assessment of Functioning (GAF) scores in a sample of 315 veterans assessed at a Department of Veterans Affairs PTSD clinic. Results showed that the association between combat exposure and GAF scores was fully mediated by PTSD severity. The best-fitting model included direct paths from combat exposure to reex-periencing symptoms and from avoidance and numbing symptoms to GAF. However, only 17% of variance in GAF was accounted for by PTSD. The results raise concern about the use of the GAF score as a benchmark for quantifying combat PTSD-related functional impairment. JF - Journal of Rehabilitation Research and Development AU - Miller, M W AU - Wolf, E J AU - Martin, E AU - Kaloupek, D G AU - Keane, T M AD - National Center for PTSD (116B-2), VA Boston Healthcare System, 150 South Huntington Ave, Boston, MA 02130, USA, Mark.Miller5@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 359 EP - 370 VL - 45 IS - 3 SN - 0748-7711, 0748-7711 KW - Health & Safety Science Abstracts KW - posttraumatic stress disorder KW - Psychology KW - Working conditions KW - benchmarks KW - Military KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20860343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Structural+equation+modeling+of+associations+among+combat+exposure%2C+PTSD+symptom+factors%2C+and+Global+Assessment+of+Functioning&rft.au=Miller%2C+M+W%3BWolf%2C+E+J%3BMartin%2C+E%3BKaloupek%2C+D+G%3BKeane%2C+T+M&rft.aulast=Miller&rft.aufirst=M&rft.date=2008-01-01&rft.volume=45&rft.issue=3&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2007.06.0085 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - posttraumatic stress disorder; Working conditions; Occupational health; Military; Psychology; benchmarks DO - http://dx.doi.org/10.1682/JRRD.2007.06.0085 ER - TY - JOUR T1 - Posttraumatic stress disorder and health functioning in a non-treatment-seeking sample of Iraq war veterans: A prospective analysis AN - 20858665; 8369560 AB - To evaluate the impact of posttraumatic stress disorder (PTSD) on health-related functioning, we assessed 800 U.S. Army soldiers before and after 1-year military deployments to Iraq. As part of the Neurocognition Deployment Health Study procedures, each soldier completed at both time points self-report indexes of PTSD symptom severity, health behaviors (smoking, alcohol use), and somatic health-related functioning. Participants also completed a health-symptom checklist at the postdeployment assessment. Structural equation modeling revealed that postdeployment PTSD severity was associated with change in somatic health-related functioning, with postdeployment health symptoms as an intermediary variable. These relationships were independent of health risk behaviors, which had little association with somatic symptoms or PTSD. Our findings highlight the functional impact of PTSD, which extends beyond psychological symptoms to health-related daily functioning. JF - Journal of Rehabilitation Research and Development AU - Vasterling, J J AU - Schumm, J AU - Proctor, S P AU - Gentry, E AD - Psychology (116B), VA Boston Healthcare System, 150 South Huntington Avenue, Boston, MA 02130, USA, jennifer.vasterling@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 347 EP - 358 VL - 45 IS - 3 SN - 0748-7711, 0748-7711 KW - Health & Safety Science Abstracts KW - Alcohol KW - posttraumatic stress disorder KW - Psychology KW - war KW - Working conditions KW - Iraq KW - Smoking KW - USA KW - Military KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20858665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Posttraumatic+stress+disorder+and+health+functioning+in+a+non-treatment-seeking+sample+of+Iraq+war+veterans%3A+A+prospective+analysis&rft.au=Vasterling%2C+J+J%3BSchumm%2C+J%3BProctor%2C+S+P%3BGentry%2C+E&rft.aulast=Vasterling&rft.aufirst=J&rft.date=2008-01-01&rft.volume=45&rft.issue=3&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2007.05.0077 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Iraq; USA; posttraumatic stress disorder; Psychology; Alcohol; Smoking; Military; Occupational health; Working conditions; war DO - http://dx.doi.org/10.1682/JRRD.2007.05.0077 ER - TY - JOUR T1 - Sexual harassment and assault experienced by reservists during military service: Prevalence and health correlates AN - 20856518; 8369565 AB - The current investigation identified the gender-specific prevalence of sexual harassment and assault experienced during U.S. military service and the negative mental and physical health correlates of these experiences in a sample of former reservists. We surveyed a stratified random sample of 3,946 former reservists about their experiences during military service and their current health, including depression, posttrau-matic stress disorder, somatic symptoms, and medical conditions. Prevalence estimates and confidence intervals of sexual harassment and assault were calculated. A series of logistic regressions identified associations with health symptoms and conditions. Both men and women had a substantial prevalence of military sexual harassment and assault. As expected, higher proportions of female reservists reported sexual harassment (60.0% vs 27.2% for males) and sexual assault (13.1% vs 1.6% for males). For both men and women, these experiences were associated with deleterious mental and physical health conditions, with sexual assault demonstrating stronger associations than other types of sexual harassment in most cases. This investigation is the first to document high instances of these experiences among reservists. These data provide further evidence that experiences of sexual harassment and assault during military service have significant implications for the healthcare needs of military veterans. JF - Journal of Rehabilitation Research and Development AU - Street, A E AU - Stafford, J AU - Mahan, C M AU - Hendricks, A AD - National Center for PTSD (116B-3), VA Boston Healthcare System, 150 South Huntington Avenue, Boston, MA 02130, USA, amv.street@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 409 EP - 420 VL - 45 IS - 3 SN - 0748-7711, 0748-7711 KW - Health & Safety Science Abstracts KW - Stress KW - depression KW - USA KW - Health care KW - Gender KW - Sexual harassment KW - Military KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20856518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Sexual+harassment+and+assault+experienced+by+reservists+during+military+service%3A+Prevalence+and+health+correlates&rft.au=Street%2C+A+E%3BStafford%2C+J%3BMahan%2C+C+M%3BHendricks%2C+A&rft.aulast=Street&rft.aufirst=A&rft.date=2008-01-01&rft.volume=45&rft.issue=3&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2007.06.0088 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - USA; Military; Gender; Occupational health; Sexual harassment; Stress; Health care; depression DO - http://dx.doi.org/10.1682/JRRD.2007.06.0088 ER - TY - JOUR T1 - Effect of the Soluble TNF-Antagonist Etanercept on Tumor Necrosis Factor Bioactivity and Stability AN - 20745166; 9391299 AB - Background: Targeted anti-tumor necrosis factor (TNF) strategies in patients with rheumatoid arthritis have resulted in new and/or worsening heart failure in individuals who were free of cardiovascular disease. Methods and Results: To determine the mechanism of new and/or worsening heart failure in patients who were receiving the soluble TNF-antagonist etanercept, we analyzed frozen plasma samples from a previous clinical trial with etanercept in heart failure patients, and conducted complimentary mechanistic in vitro studies. Analysis of the clinical trial data showed that use of etanercept resulted in a significant 70-fold increase in the level of immunoreactive TNF. Complimentary in vitro studies using an L929 bioassay showed that at low concentrations of etanercept relative to TNF there was an unexpected 1.5- to 1.75-fold increase in the absolute level of TNF bioactivity. We also examined the effect of etanercept on TNF stability and the results showed that there was a two-fold increase in the mass of bioactive homotrimeric TNF when the molar ratio of TNF to etanercept was approximately 200:1. Conclusion: Etanercept increases the immunoreactive mass of TNF in heart failure patients, as well as augments TNF cytotoxicity in certain settings, thus suggesting one potential mechanism for the worsening heart failure in some patients who were receiving this agent. JF - Clinical and Translational Science AU - Mann, D L AU - Bozkurt, B AU - Torre-Amione, G AU - Soran, OZ AU - Sivasubramanian, N AD - Winters Center for Heart Failure Research, Texas Heart Institute at St. Luke's Episcopal Hospital, Department of Medicine Veterans Administration Medical Center, Baylor College of Medicine, Houston, Texas, USA, dmann@bcm.edu Y1 - 2008 PY - 2008 DA - 2008 SP - 142 EP - 145 VL - 1 IS - 2 SN - 1752-8054, 1752-8054 KW - Microbiology Abstracts B: Bacteriology KW - etanercept KW - Translation KW - Cytotoxicity KW - Rheumatoid arthritis KW - Data processing KW - Tumor necrosis factor KW - Cardiovascular diseases KW - Clinical trials KW - Heart diseases KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20745166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Translational+Science&rft.atitle=Effect+of+the+Soluble+TNF-Antagonist+Etanercept+on+Tumor+Necrosis+Factor+Bioactivity+and+Stability&rft.au=Mann%2C+D+L%3BBozkurt%2C+B%3BTorre-Amione%2C+G%3BSoran%2C+OZ%3BSivasubramanian%2C+N&rft.aulast=Mann&rft.aufirst=D&rft.date=2008-01-01&rft.volume=1&rft.issue=2&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Translational+Science&rft.issn=17528054&rft_id=info:doi/10.1111%2Fj.1752-8062.2008.00013.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Translation; etanercept; Rheumatoid arthritis; Cytotoxicity; Data processing; Tumor necrosis factor; Cardiovascular diseases; Clinical trials; Heart diseases DO - http://dx.doi.org/10.1111/j.1752-8062.2008.00013.x ER - TY - JOUR T1 - A Model for Evaluating Interface Terminologies AN - 20447839; 7934923 AB - OBJECTIVE: Evaluations of individual terminology systems should be driven in part by the intended usages of such systems. Clinical interface terminologies support interactions between healthcare providers and computer-based applications. They aid practitioners in converting clinical "free text" thoughts into the structured, formal data representations used internally by application programs. Interface terminologies also serve the important role of presenting existing stored, encoded data to end users in human-understandable and actionable formats. The authors present a model for evaluating functional utility of interface terminologies based on these intended uses. DESIGN: Specific parameters defined in the manuscript comprise the metrics for the evaluation model. MEASUREMENTS: Parameters include concept accuracy, term expressivity, degree of semantic consistency for term construction and selection, adequacy of assertional knowledge supporting concepts, degree of complexity of pre-coordinated concepts, and the "human readability" of the terminology. The fundamental metric is how well the interface terminology performs in supporting correct, complete, and efficient data encoding or review by humans. RESULTS: Authors provide examples demonstrating performance of the proposed evaluation model in selected instances. CONCLUSION: A formal evaluation model will permit investigators to evaluate interface terminologies using a consistent and principled approach. Terminology developers and evaluators can apply the proposed model to identify areas for improving interface terminologies. JF - Journal of the American Medical Informatics Association AU - Rosenbloom, STrent AU - Miller, Randolph A AU - Johnson, Kevin B AU - Elkin, Peter L AU - Brown, Steven H AD - Department of Biomedical Informatics, Vanderbilt University, Nashville, TN. School of Nursing, Vanderbilt University, Nashville, TN. Department of Pediatrics, Vanderbilt University, Nashville, TN. Mayo Foundation for Medical Education and Research, Rochester, MN. U.S. Department of Veterans Affairs, Nashville, TN Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 65 EP - 76 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 15 IS - 1 SN - 1067-5027, 1067-5027 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Reviews KW - Models KW - Semantics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20447839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=A+Model+for+Evaluating+Interface+Terminologies&rft.au=Rosenbloom%2C+STrent%3BMiller%2C+Randolph+A%3BJohnson%2C+Kevin+B%3BElkin%2C+Peter+L%3BBrown%2C+Steven+H&rft.aulast=Rosenbloom&rft.aufirst=STrent&rft.date=2008-01-01&rft.volume=15&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Reviews; Semantics; Models ER - TY - JOUR T1 - Novel Roles in Human MD-2 of Phenylalanines 121 and 126 and Tyrosine 131 in Activation of Toll-like Receptor 4 by Endotoxin AN - 19997386; 8038264 AB - Potent mammalian cell activation by Gram-negative bacterial endotoxin requires sequential protein-endotoxin and protein-protein interactions involving lipopolysaccharide-binding protein, CD14, MD-2, and Toll-like receptor 4 (TLR4). TLR4 activation requires simultaneous binding of MD-2 to endotoxin (E) and the ectodomain of TLR4. We now describe mutants of recombinant human MD-2 that bind TLR4 and react with E.CD14 but do not support cellular responsiveness to endotoxin. The mutants F121A/K122A MD-2 and Y131A/K132A MD-2 react with E.CD14 only when co-expressed with TLR4. Single mutants K122A and K132A each react with E.CD14 plus or minus TLR4 and promote TLR4-dependent cell activation by endotoxin suggesting that Phe super(121) and Tyr super(131) are needed for TLR4-independent transfer of endotoxin from CD14 to MD-2 and also needed for TLR4 activation by bound E.MD-2. The mutant F126A MD-2 reacts as well as wild-type MD-2 with E.CD14 plus or minus TLR4. E.MD-2 super(F126A) binds TLR4 with high affinity (K sub(d) similar to 200 pM) but does not activate TLR4 and instead acts as a potent TLR4 antagonist, inhibiting activation of HEK/TLR4 cells by wild-type E.MD-2. These findings reveal roles of Phe super(121) and Tyr super(131) in TLR4-independent interactions of human MD-2 with E.CD14 and, together with Phe super(126), in activation of TLR4 by bound E.MD-2. These findings strongly suggest that the structural properties of E.MD-2, not E alone, determine agonist or antagonist effects on TLR4. JF - Journal of Biological Chemistry AU - Teghanemt, Athmane AU - Re, Fabio AU - Prohinar, Polonca AU - Widstrom, Richard AU - Gioannini, Theresa L AU - Weiss, Jerrold P AD - Department of Internal Medicine and The Inflammation Program, the Department of Microbiology, and the Department of Biochemistry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, the Veterans' Administration Medical Center, Iowa City, Iowa 52246, and the Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163 Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 1257 EP - 1266 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 3 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Endotoxins KW - Mammalian cells KW - Tyrosine KW - CD14 antigen KW - TLR4 protein KW - Phenylalanine KW - Lipopolysaccharide-binding protein KW - Toll-like receptors KW - Protein interaction KW - Cell activation KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19997386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Novel+Roles+in+Human+MD-2+of+Phenylalanines+121+and+126+and+Tyrosine+131+in+Activation+of+Toll-like+Receptor+4+by+Endotoxin&rft.au=Teghanemt%2C+Athmane%3BRe%2C+Fabio%3BProhinar%2C+Polonca%3BWidstrom%2C+Richard%3BGioannini%2C+Theresa+L%3BWeiss%2C+Jerrold+P&rft.aulast=Teghanemt&rft.aufirst=Athmane&rft.date=2008-01-01&rft.volume=283&rft.issue=3&rft.spage=1257&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Endotoxins; Mammalian cells; Tyrosine; CD14 antigen; Lipopolysaccharide-binding protein; Phenylalanine; TLR4 protein; Protein interaction; Toll-like receptors; Cell activation ER - TY - JOUR T1 - Headaches among Operation Iraqi Freedom/Operation Enduring Freedom veterans with mild traumatic brain injury associated with exposures to explosions AN - 19666945; 9016792 AB - Traumatic brain injury (TBI) is a common injury type among Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) veterans, and headaches are a frequent consequence of TBI. We examined the hypothesis that among veterans who reported mild TBI caused by exposure to an explosion during deployment in OIF/OEF, those with residual neurocognitive deficits would have a higher frequency of headaches and more severe headaches. We evaluated 155 consecutive veterans with neurological examination and neuropsychological testing. We excluded 29 veterans because they did not have mild TBI or they did not complete the evaluation. We analyzed headache pattern, intensity, and frequency. Among the 126 veterans studied, 80 had impairments on neurological examination or neuropsychological testing that were best attributed to TBI. Veterans with impairments had been exposed to more explosions and were more likely to have headache, features of migraine, more severe pain, more frequent headaches, posttraumatic stress disorder, and impaired sleep with nightmares. JF - Journal of Rehabilitation Research and Development AU - Ruff, R L AU - Ruff, S S AU - Wang, X-F AD - Neurology Service and Polytrauma System of Care, Louis Stokes Cleveland Department of Veterans Affairs Medical Center (VAMC), Cleveland, OH, USA, Robert.Ruff1@va.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 941 EP - 952 VL - 45 IS - 7 SN - 0748-7711, 0748-7711 KW - Health & Safety Science Abstracts; CSA Neurosciences Abstracts KW - Rehabilitation KW - Injuries KW - Psychology KW - Measuring techniques KW - Brain KW - pain KW - Pain KW - Post-traumatic stress disorder KW - Cognition KW - Explosions KW - Migraine KW - Sleep KW - Headache KW - Traumatic brain injury KW - Research programs KW - H 7000:Fire Safety KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19666945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Headaches+among+Operation+Iraqi+Freedom%2FOperation+Enduring+Freedom+veterans+with+mild+traumatic+brain+injury+associated+with+exposures+to+explosions&rft.au=Ruff%2C+R+L%3BRuff%2C+S+S%3BWang%2C+X-F&rft.aulast=Ruff&rft.aufirst=R&rft.date=2008-01-01&rft.volume=45&rft.issue=7&rft.spage=941&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2008.02.0028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Injuries; Explosions; Brain; Psychology; pain; Research programs; Headache; Traumatic brain injury; Measuring techniques; Rehabilitation; Post-traumatic stress disorder; Sleep; Cognition; Migraine; Pain DO - http://dx.doi.org/10.1682/JRRD.2008.02.0028 ER - TY - JOUR T1 - Amyloid- beta precursor protein expression and modulation in human embryonic stem cells: A novel role for human chorionic gonadotropin AN - 19899889; 7786736 AB - The amyloid- beta precursor protein (A beta PP) is a ubiquitously expressed adhesion and neuritogenic protein whose processing has previously been shown to be regulated by reproductive hormones including the gonadotropin luteinizing hormone (LH) in human neuroblastoma cells. We report for the first time the expression of A beta PP in human embryonic stem (hES) cells at the mRNA and protein levels. Using N- and C-terminal antibodies against A beta PP, we detected both the mature and immature forms of A beta PP as well as truncated variants (~53kDa, 47kDa, and 29kDa) by immunoblot analyses. Expression of A beta PP is regulated by both the stemness of the cells and pregnancy-associated hormones. Addition of human chorionic gonadotropin, the fetal equivalent of LH that is dramatically elevated during pregnancy, markedly increased the expression of all A beta PP forms. These results indicate a critical molecular signaling link between the hormonal environment of pregnancy and the expression of A beta PP in hES cells that is suggestive of an important function for this protein during early human embryogenesis prior to the formation of neural precursor cells. JF - Biochemical and Biophysical Research Communications AU - Porayette, P AU - Gallego, MJ AU - Kaltcheva, M M AU - Meethal, S V AU - Atwood, C S AD - Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA, csa@medicine.wisc.edu Y1 - 2007/12/21/ PY - 2007 DA - 2007 Dec 21 SP - 522 EP - 527 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 364 IS - 3 SN - 0006-291X, 0006-291X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Genetics Abstracts KW - chorionic gonadotropin KW - Gonadotropins KW - Hormones KW - Fetuses KW - mRNA KW - Pregnancy KW - Antibodies KW - Stem cells KW - Embryogenesis KW - Embryo cells KW - Luteinizing hormone KW - Neuroblastoma cells KW - Axonogenesis KW - beta -Amyloid KW - Neural stem cells KW - Signal transduction KW - G 07880:Human Genetics KW - W 30940:Products KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19899889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Amyloid-+beta+precursor+protein+expression+and+modulation+in+human+embryonic+stem+cells%3A+A+novel+role+for+human+chorionic+gonadotropin&rft.au=Porayette%2C+P%3BGallego%2C+MJ%3BKaltcheva%2C+M+M%3BMeethal%2C+S+V%3BAtwood%2C+C+S&rft.aulast=Porayette&rft.aufirst=P&rft.date=2007-12-21&rft.volume=364&rft.issue=3&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2007.10.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - chorionic gonadotropin; Gonadotropins; Hormones; Fetuses; Pregnancy; mRNA; Embryogenesis; Stem cells; Antibodies; Embryo cells; Luteinizing hormone; Neuroblastoma cells; Axonogenesis; beta -Amyloid; Neural stem cells; Signal transduction DO - http://dx.doi.org/10.1016/j.bbrc.2007.10.021 ER - TY - JOUR T1 - Edema in a patient receiving methadone for chronic low back pain. AN - 69016515; 18056943 AB - The case of a patient who developed edema after receiving methadone for chronic low back pain is reported. A 45-year-old white woman developed edema in her lower extremities one week after starting methadone, etodolac, and gabapentin as part of her treatment for chronic low back pain. She was taking methadone as part of her treatment regimen to manage her pain in addition to other agents, including etodolac and gabapentin. After several days on this therapy, she developed edema and stated that she was "feeling drunk." At that time the etodolac and gabapentin were stopped, and the methadone dosage was increased. Several days later, the patient returned to the pain clinic, complaining of continued swelling. The methadone dosage was then decreased, and a diuretic was added to treat the edema; however, her edema did not resolve with the lower dosage of methadone. Methadone was then discontinued, and a fentanyl patch was prescribed. Prednisone was also prescribed, and the dosage of the diuretic was increased. The patient's symptoms resolved, and prednisone was ultimately tapered. The likelihood that the administration of methadone was related to the development of edema in this patient was determined to be probable. There have been a few cases reported in the literature regarding the development of edema with methadone use. In the cases reported, the edema developed after three to six months of methadone therapy. A patient with chronic low back pain developed edema one week after receiving methadone as part of her pain management regimen. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Kharlamb, Viktoria AU - Kourlas, Helen AD - Department of Pharmacy, Department of Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, USA. viktoria.kharlamb@va.gov Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 2557 EP - 2560 VL - 64 IS - 24 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Humans KW - Middle Aged KW - Chronic Disease KW - Female KW - Low Back Pain -- drug therapy KW - Methadone -- adverse effects KW - Edema -- chemically induced KW - Edema -- diagnosis KW - Low Back Pain -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69016515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Edema+in+a+patient+receiving+methadone+for+chronic+low+back+pain.&rft.au=Kharlamb%2C+Viktoria%3BKourlas%2C+Helen&rft.aulast=Kharlamb&rft.aufirst=Viktoria&rft.date=2007-12-15&rft.volume=64&rft.issue=24&rft.spage=2557&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=1535-2900&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-04 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Health Syst Pharm. 2008 Sep 1;65(17):1599-600; author reply 1600-1 [18714100] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Infection of Hamsters with Historical and Epidemic BI Types of Clostridium difficile AN - 20967552; 8452154 AB - Background. North American and European hospitals have reported outbreaks of Clostridium difficile-associated disease with unexpectedly high mortality caused by a newly recognized group of C. difficile strains, group BI. Our objective was to compare. in hamsters, the virulence of a historical nonepidemic BI type, BI1, with that of 2 recent epidemic BI types, BI6 and BI17, and with that of 2 standard toxigenic strains, K14 and 630. Methods. For each strain, 10 hamsters were given 1 dose of clindamycin, followed 5 days later with 100 C. difficile spores administered by gastric inoculation. Outcomes were recorded. Results. The hamster model demonstrated variations in mean times from inoculation to death (for BI6, 40 h; for BI1, 48 h; for K14, 49 h; for BI17, 69 h; for 630, 102 h; for BI6, BI1, and K14 vs. 630, P < .01; for BI17 vs. 630, P < .05) and from colonization to death (for BI1, 7 h; for BI17, 13 h; for BI6, 16 h; for K14, 17 h; for 630, 52 h; for BI1, BI17, BI6, and K14 vs. 630, P < .01). Conclusion. Group BI strains were not more rapidly fatal than the standard toxinotype 0 strain K14 but were more rapidly fatal than the standard toxinotype 0 strain 630. BI6, the most common BI type in our collection, was particularly virulent in hamsters, consistently causing death within 48 h of inoculation. JF - Journal of Infectious Diseases AU - Razaq, N AU - Sambol, S AU - Nagaro, K AU - Zukowski, W AU - Cheknis, A AU - Johnson, S AU - Gerding, D N AD - ACOS Research and Development, Hines VA Hospital, 5th Ave. and Roosevelt Rd., Bldg. 1, Rm. C344, Hines, IL 60141, USA, dale.gerding2@va.gov Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 1813 EP - 1819 VL - 196 IS - 12 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology KW - Clostridium KW - Mortality KW - Clindamycin KW - Epidemics KW - Animal models KW - Infection KW - Virulence KW - Colonization KW - Inoculation KW - Clostridium difficile KW - Spores KW - Hospitals KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20967552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Infection+of+Hamsters+with+Historical+and+Epidemic+BI+Types+of+Clostridium+difficile&rft.au=Razaq%2C+N%3BSambol%2C+S%3BNagaro%2C+K%3BZukowski%2C+W%3BCheknis%2C+A%3BJohnson%2C+S%3BGerding%2C+D+N&rft.aulast=Razaq&rft.aufirst=N&rft.date=2007-12-15&rft.volume=196&rft.issue=12&rft.spage=1813&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F523106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Virulence; Mortality; Colonization; Clindamycin; Epidemics; Animal models; Inoculation; Infection; Spores; Hospitals; Clostridium; Clostridium difficile DO - http://dx.doi.org/10.1086/523106 ER - TY - JOUR T1 - Comparison of distortion product otoacoustic emissions in 28 inbred strains of mice. AN - 85407013; pmid-17997239 AB - Cochlear function was evaluated in a longitudinal study of 28 inbred strains of mice at 3 and 5 mo of age using measures of distortion product otoacoustic emissions (DPOAEs) in response to a federal initiative to develop rapid mouse phenotyping methodologies. DP-grams at f(2) frequencies ranging from 6.3 to 54.2kHz were obtained in about 3min/ear by eliciting 2f(1)-f(2) DPOAEs in 0.1-octave steps of f(2) with primary tones at L(1)=L(2) =55, 65, and 75dB SPL. CBA/CaJ mice exhibited average levels of approximately 26dB SPL and this strain was selected as the normal reference strain against which the others were compared. Based upon the configurations of their DP-grams, the 28 mouse strains could be categorized into four distinct groups. That is, nine of the strains including the CBA were designated as the CBA-like group because these mice displayed robust DPOAE levels across frequency. In contrast, the remaining three groups all exhibited irregular DP-gram patterns. Specifically, eight of the remaining 19 strains showed a progressive high- to low-frequency reduction in DPOAE levels that was typical of age-related hearing loss (AHL) associated with mouse strains homozygous for the ahl allele and were labeled as AHL-like strains. Seven strains demonstrating relatively even patterns of reduced DPOAE levels across the frequency-test range were designated as Flat-loss strains. Finally, the remaining four strains exhibited no measurable DPOAEs at either 3 or 5 mo of age and thus were classified as Absent strains. Extending the f(2) test frequencies up to approximately 54kHz led to the detection of very early-onset reductions in cochlear function in non-CBA-like groups so that all strains could be categorized by 3 mo of age. Predictably, the AHL-like strains showed more pronounced DPOAE losses at 5 mo than at 3 mo. A similar deterioration in DPOAE levels was not apparent for the Flat-loss strains. Both the AHL-like and Flat-loss strains showed considerably more variability in DPOAE levels than did the CBA-like strains. Together, these findings indicate that DP-grams adequately reveal both frequency-specific loss patterns and details of inbred strain variability. JF - Hearing research AU - Martin, Glen K AU - Vazquez, Ana E AU - Jimenez, Ana M AU - Stagner, Barden B AU - Howard, Mackenzie A AU - Lonsbury-Martin, Brenda L AD - Research Service, Jerry L Pettis Memorial Veterans Affairs Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA. glen.martin2@va.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 59 EP - 72 VL - 234 IS - 1-2 SN - 0378-5955, 0378-5955 KW - National Library of Medicine KW - Acoustic Stimulation KW - Aging KW - Animals KW - *Cochlea: physiopathology KW - Hair Cells, Auditory, Outer: pathology KW - *Hearing Tests KW - Mice KW - Mice, Inbred Strains KW - *Otoacoustic Emissions, Spontaneous KW - Phenotype KW - *Presbycusis: diagnosis KW - Presbycusis: pathology KW - Presbycusis: physiopathology KW - Species Specificity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85407013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+research&rft.atitle=Comparison+of+distortion+product+otoacoustic+emissions+in+28+inbred+strains+of+mice.&rft.au=Martin%2C+Glen+K%3BVazquez%2C+Ana+E%3BJimenez%2C+Ana+M%3BStagner%2C+Barden+B%3BHoward%2C+Mackenzie+A%3BLonsbury-Martin%2C+Brenda+L&rft.aulast=Martin&rft.aufirst=Glen&rft.date=2007-12-01&rft.volume=234&rft.issue=1-2&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Hearing+research&rft.issn=03785955&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2012-04-19 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Carisoprodol abuse in Mississippi. AN - 70140292; 19292137 JF - Journal of the Mississippi State Medical Association AU - Reeves, Roy R AU - Henderson, Randolph H AU - Ladner, Mark E AD - VA Medical Center, Jackson, MS 39216, USA. roy.reeves@med.va.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 363 EP - 365 VL - 48 IS - 12 SN - 0026-6396, 0026-6396 KW - Muscle Relaxants, Central KW - 0 KW - Prescription Drugs KW - Carisoprodol KW - 21925K482H KW - Index Medicus KW - Humans KW - Psychomotor Agitation -- etiology KW - Psychomotor Agitation -- diagnosis KW - Adult KW - Mississippi -- epidemiology KW - Male KW - Substance-Related Disorders -- diagnosis KW - Carisoprodol -- adverse effects KW - Muscle Relaxants, Central -- adverse effects KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70140292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Mississippi+State+Medical+Association&rft.atitle=Carisoprodol+abuse+in+Mississippi.&rft.au=Reeves%2C+Roy+R%3BHenderson%2C+Randolph+H%3BLadner%2C+Mark+E&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2007-12-01&rft.volume=48&rft.issue=12&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Mississippi+State+Medical+Association&rft.issn=00266396&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-28 N1 - Date created - 2009-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cognitive function in older diabetic subjects with a history of alcohol abuse. AN - 70119718; 18361128 AB - Either diabetes or alcohol abuse can impair cognitive function, especially at older ages. Whether a history of alcohol abuse increases the risk for cognitive impairment in diabetic patients has not been examined. Cognitive function of type 2 diabetic subjects with a history of alcohol abuse was expected to be more impaired than that of subjects with either diabetes or alcohol abuse alone. Men, 55 years of age, were categorized as 15 alcoholic-diabetic; 15 alcoholic-nondiabetic; 15 nonalcoholic-diabetic; 15 nonalcoholic-nondiabetic, and matched on age, sex, and education. Participants' verbal memory, visuospatial memory, and executive functions were assessed using a neurocognitive test battery. Significant interactions of diabetes and alcoholism for Visual Delayed Recall, Story Immediate Recall, and Story Delayed Recall implied that diabetes and alcohol abuse enhanced each other's effect in lowering cognitive test scores. Alcohol abuse history in older diabetic subjects presents an increased risk for cognitive impairment. JF - Psychological reports AU - Hudetz, Judith A AU - Warltier, David C AD - Department of Anesthesiology, Medical College of Wisconsin, Zablocki Veterans Administration Medical Center, Milwaukee 53295, USA. judith.hudetz@va.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1125 EP - 1132 VL - 101 IS - 3 Pt 2 SN - 0033-2941, 0033-2941 KW - Index Medicus KW - Depressive Disorder -- epidemiology KW - Cross-Sectional Studies KW - Coronary Disease -- diagnosis KW - Depressive Disorder -- psychology KW - Aged, 80 and over KW - Humans KW - Depressive Disorder -- diagnosis KW - Coronary Disease -- epidemiology KW - Aged KW - Middle Aged KW - Coronary Disease -- psychology KW - Psychometrics KW - Male KW - Female KW - Neuropsychological Tests -- statistics & numerical data KW - Alcoholism -- rehabilitation KW - Cognition Disorders -- diagnosis KW - Cognition Disorders -- epidemiology KW - Diabetes Mellitus, Type 2 -- epidemiology KW - Diabetes Mellitus, Type 2 -- psychology KW - Alcoholism -- psychology KW - Diabetes Complications -- diagnosis KW - Diabetes Complications -- psychology KW - Alcoholism -- epidemiology KW - Diabetes Complications -- epidemiology KW - Alcoholism -- complications KW - Cognition Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70119718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+reports&rft.atitle=Cognitive+function+in+older+diabetic+subjects+with+a+history+of+alcohol+abuse.&rft.au=Hudetz%2C+Judith+A%3BWarltier%2C+David+C&rft.aulast=Hudetz&rft.aufirst=Judith&rft.date=2007-12-01&rft.volume=101&rft.issue=3+Pt+2&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=Psychological+reports&rft.issn=00332941&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-01 N1 - Date created - 2008-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cytotoxicity of Abeta1-42, RAGE23-54, and an Abeta-RAGE complex in PC-12 cells. AN - 70080042; 18220528 AB - The receptor for advanced glycation end products (RAGE) binds amyloid peptides with high affinity. Soluble RAGE-like peptides and Abeta-like peptides occur in relatively high concentrations in the circulation of individuals with Alzheimer's disease. Protein complexes with epitopes for both Abeta and RAGE are also present. At physiological concentrations, forms of Abeta have different, but relatively low potencies as cytotoxicants in neural cells in culture. The purpose of this study was to determine whether a synthetic peptide complex composed of Abeta(1-42) and RAGE(23-54), a conserved N-terminal fragment of RAGE, exhibited increased cytotoxicity in comparison with the constituent peptides. Western analysis indicated that Abeta(1-42) and RAGE(23-54) remained primarily in their original low molecular weight states (4-6 kDa) during the maintenance of the individual peptides (37 degrees C) in water from 1 to 4 weeks. In contrast, over the same maintenance periods the combined Abeta(1-42) and RAGE(23-54) peptides shifted to higher molecular weight complexes (up to 80-120 kDa). Protein complexes of similar molecular weights with epitopes for Abeta and RAGE antibodies were identified in human plasma. Incubation of differentiated PC-12 cells with 10-100 microM Abeta(1-42) or with RAGE(23-54) resulted in concentration-dependent decreases in cell viability. The cytotoxicity of each peptide was slightly enhanced by the progressive maintenance of Abeta(1-42) and RAGE(23-54) in water over 3 weeks prior to the assay. Under the same conditions, the Abeta(1-42) - RAGE(23-54) complex became significantly more cytotoxic. These results suggest that the formation of soluble Abeta-RAGE complexes in Alzheimer's disease could represent a mechanism for enhancing the neurotoxicity of amyloid peptides. JF - Current Alzheimer research AU - Mruthinti, Shyamala AU - Capito, Nicholas AU - Sood, Ajay AU - Buccafusc, Jerry J AD - Veterans Administration Medical Center, Augusta, Georgia 30904-6285, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 581 EP - 586 VL - 4 IS - 5 SN - 1567-2050, 1567-2050 KW - Amyloid beta-Peptides KW - 0 KW - Drug Combinations KW - Glycosylation End Products, Advanced KW - Peptide Fragments KW - amyloid beta-protein (1-42) KW - Index Medicus KW - Rats KW - Animals KW - Analysis of Variance KW - Humans KW - Time Factors KW - Peptide Fragments -- toxicity KW - PC12 Cells -- metabolism KW - Cell Survival -- drug effects KW - Amyloid beta-Peptides -- metabolism KW - Glycosylation End Products, Advanced -- chemistry KW - Amyloid beta-Peptides -- toxicity KW - PC12 Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70080042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Alzheimer+research&rft.atitle=Cytotoxicity+of+Abeta1-42%2C+RAGE23-54%2C+and+an+Abeta-RAGE+complex+in+PC-12+cells.&rft.au=Mruthinti%2C+Shyamala%3BCapito%2C+Nicholas%3BSood%2C+Ajay%3BBuccafusc%2C+Jerry+J&rft.aulast=Mruthinti&rft.aufirst=Shyamala&rft.date=2007-12-01&rft.volume=4&rft.issue=5&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Current+Alzheimer+research&rft.issn=15672050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-21 N1 - Date created - 2008-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Are depressed outpatients with and without a family history of substance use disorder different? A baseline analysis of the STAR*D cohort. AN - 69086832; 18162025 AB - This report compares the baseline demographic and clinical characteristics of outpatients with nonpsychotic major depressive disorder (MDD) and a family history of substance use disorder (SUD) versus those with MDD and no family history of SUD. Using data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, we grouped participants with MDD (DSM-IV criteria) according to presence or absence of family history of SUD based on participant report. Between-group comparisons were made of demographic and clinical characteristics, depressive symptoms, and psychiatric co-morbidities. Patients were enrolled from July 2001 until August 2004. Of 4010 participants, 46% had a positive family history of SUD. Those with a positive family history were less likely to be Hispanic (p = .0029) and more likely to be female (p = .0013). They were less educated (p = .0120), less likely to be married (p < .01), and more likely to be divorced (p < .01). They also reported an earlier age at onset of MDD, greater length of illness, and more major depressive episodes (all p < .001). They had an increased likelihood of recurrent MDD, more prior suicide attempts, and more concurrent psychiatric comorbidities, including posttraumatic stress disorder, SUD, and generalized anxiety disorder (all p < .0001). Depressed patients with a family history of SUD had a more severe previous course of depression, were more likely to have attempted suicide, and had a greater burden of psychiatric comorbid conditions than patients without such a family history. These findings represent important clinical features to be considered in the evaluation and treatment planning of patients with MDD. JF - The Journal of clinical psychiatry AU - Davis, Lori L AU - Frazier, Elizabeth C AU - Gaynes, Bradley N AU - Trivedi, Madhukar H AU - Wisniewski, Stephen R AU - Fava, Maurizio AU - Barkin, Jennifer AU - Kashner, T Michael AU - Shelton, Richard C AU - Alpert, Jonathan E AU - Rush, A John AD - Department of Veterans Affairs (VA) Medical Center, Tuscaloosa, Ala. 35404, USA. lori.davis@va.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1931 EP - 1938 VL - 68 IS - 12 KW - Index Medicus KW - Pedigree KW - Outpatients KW - Multicenter Studies as Topic KW - Randomized Controlled Trials as Topic KW - Suicide, Attempted KW - Age of Onset KW - Humans KW - Aged KW - Recurrence KW - Comorbidity KW - Demography KW - Risk Factors KW - Adult KW - Cohort Studies KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Depressive Disorder, Major -- drug therapy KW - Depressive Disorder, Major -- psychology KW - Depressive Disorder, Major -- epidemiology KW - Depressive Disorder, Major -- genetics KW - Substance-Related Disorders -- genetics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69086832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Are+depressed+outpatients+with+and+without+a+family+history+of+substance+use+disorder+different%3F+A+baseline+analysis+of+the+STAR*D+cohort.&rft.au=Davis%2C+Lori+L%3BFrazier%2C+Elizabeth+C%3BGaynes%2C+Bradley+N%3BTrivedi%2C+Madhukar+H%3BWisniewski%2C+Stephen+R%3BFava%2C+Maurizio%3BBarkin%2C+Jennifer%3BKashner%2C+T+Michael%3BShelton%2C+Richard+C%3BAlpert%2C+Jonathan+E%3BRush%2C+A+John&rft.aulast=Davis&rft.aufirst=Lori&rft.date=2007-12-01&rft.volume=68&rft.issue=12&rft.spage=1931&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=1555-2101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-12-28 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00021528; ClinicalTrials.gov N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. AN - 68544705; 18022203 AB - Evidence indicates that monoaminergic neurotransmitter transporters are promiscuous, transporting substrates other than their cognate neurotransmitters. For example, serotonin is transported by the dopamine transporter (DAT) under conditions in which serotonin transporter (SERT) activity is eliminated (e.g., pharmacological inhibition). We performed a kinetic analysis of [(3)H]serotonin uptake in rat striatal synaptosomes (expressing DAT and SERT) and hippocampal synaptosomes (expressing SERT, but not DAT). Nonspecific [(3)H]serotonin uptake was defined as the amount of uptake remaining in the presence of fluoxetine (10microM) or paroxetine (0.05microM). In hippocampal synaptosomes, K(m) and V(max) values for [(3)H]serotonin uptake did not differ whether fluoxetine or paroxetine was used to define nonspecific uptake. However, in striatal synaptosomes, both K(m) and V(max) values for [(3)H]serotonin uptake were greater when fluoxetine, rather than paroxetine, was used to define nonspecific uptake. These data suggest that, at the concentrations employed, fluoxetine inhibits serotonin uptake at both DAT and SERT, whereas paroxetine only inhibits serotonin uptake at SERT. Thus, when DAT is inhibited by GBR 12909, kinetic parameters for serotonin uptake via SERT in striatum are not different from those obtained in hippocampus. These findings have important implications regarding the analysis of monoaminergic reuptake in brain regions exhibiting heterogeneous transporter expression. JF - Neuropharmacology AU - Norrholm, Seth D AU - Horton, David B AU - Dwoskin, Linda P AD - College of Pharmacy, Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536-0082, USA. seth.norrholm@va.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 982 EP - 989 VL - 53 IS - 8 SN - 0028-3908, 0028-3908 KW - Dopamine Uptake Inhibitors KW - 0 KW - Piperazines KW - Pyrimidines KW - Serotonin Uptake Inhibitors KW - Tritium KW - 10028-17-8 KW - Serotonin KW - 333DO1RDJY KW - Paroxetine KW - 41VRH5220H KW - vanoxerine KW - 90X28IKH43 KW - fluoxydine KW - XB4K113EL0 KW - Index Medicus KW - Tritium -- pharmacokinetics KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Pyrimidines -- pharmacology KW - Serotonin Uptake Inhibitors -- pharmacology KW - Piperazines -- pharmacology KW - Paroxetine -- pharmacology KW - Male KW - Dopamine Uptake Inhibitors -- pharmacology KW - Synaptosomes -- drug effects KW - Hippocampus -- ultrastructure KW - Corpus Striatum -- ultrastructure KW - Serotonin -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68544705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=The+promiscuity+of+the+dopamine+transporter%3A+implications+for+the+kinetic+analysis+of+%5B3H%5Dserotonin+uptake+in+rat+hippocampal+and+striatal+synaptosomes.&rft.au=Norrholm%2C+Seth+D%3BHorton%2C+David+B%3BDwoskin%2C+Linda+P&rft.aulast=Norrholm&rft.aufirst=Seth&rft.date=2007-12-01&rft.volume=53&rft.issue=8&rft.spage=982&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-21 N1 - Date created - 2007-11-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroscience. 1999;94(3):821-30 [10579573] Neuron. 2005 Apr 7;46(1):65-74 [15820694] J Comp Neurol. 2000 May 1;420(2):211-32 [10753308] Neurosci Lett. 2000 Jul 21;288(3):246-8 [10889353] Biol Psychiatry. 2001 Sep 1;50(5):345-50 [11543737] Endocr Regul. 2001 Sep;35(3):119-26 [11674840] J Med Chem. 2002 Apr 25;45(9):1930-41 [11960503] Brain Res. 2002 May 17;936(1-2):58-67 [11988230] Brain Res. 2002 Jun 28;942(1-2):109-19 [12031859] J Pharmacol Exp Ther. 2002 Jul;302(1):174-9 [12065714] Neuropsychopharmacology. 2002 Dec;27(6):949-59 [12464452] Eur J Pharmacol. 2003 Jan 1;458(1-2):31-6 [12498904] Eur J Neurosci. 2003 Feb;17(3):494-506 [12581167] J Med Chem. 2003 May 8;46(10):1997-2007 [12723962] Psychopharmacol Bull. 2003 Spring;37 Suppl 1:8-18 [14566196] Synapse. 2004 Sep 1;53(3):176-83 [15236350] J Physiol. 1968 Feb;194(3):609-26 [5636991] Naunyn Schmiedebergs Arch Pharmacol. 1972;274(4):410-4 [4263633] Biochem Pharmacol. 1973 Dec 1;22(23):3099-108 [4202581] Anal Biochem. 1976 May 7;72:248-54 [942051] J Biol Chem. 1988 May 5;263(13):6115-21 [3360776] FEBS Lett. 1989 Nov 6;257(2):341-4 [2583282] Brain Res. 1989 Dec 11;504(1):64-71 [2598017] Brain Res. 1990 May 7;515(1-2):173-80 [2357555] Med Res Rev. 1991 Jan;11(1):17-34 [1994152] J Neural Transm Gen Sect. 1992;87(1):1-14 [1346964] J Pharmacol Exp Ther. 1992 Jul;262(1):356-64 [1352552] J Pharmacol Exp Ther. 1994 Jul;270(1):296-309 [8035327] J Neurosci. 1995 Mar;15(3 Pt 1):1714-23 [7534339] Brain Res. 1995 Mar 13;674(1):163-6 [7773688] J Comp Neurol. 1995 Aug 21;359(2):340-9 [7499533] J Neurochem. 1996 Jan;66(1):210-5 [8522956] J Neurocytol. 1996 Dec;25(12):843-56 [9023729] J Pharmacol Exp Ther. 2005 Aug;314(2):906-15 [15860577] Neurochem Int. 2005 Oct;47(5):350-61 [15979209] Pharmacol Biochem Behav. 2005 Aug;81(4):894-900 [16023186] Biochem Pharmacol. 2007 Jan 1;73(1):147-54 [17046718] J Med Chem. 1997 Feb 28;40(5):705-16 [9057857] J Comp Neurol. 1997 Nov 17;388(2):211-27 [9368838] Jpn J Pharmacol. 1997 Oct;75(2):123-8 [9414026] Brain Res. 1998 Jul 13;799(1):78-83 [9666084] J Pharmacol Exp Ther. 1998 Aug;286(2):967-76 [9694957] Brain Res. 1998 Sep 14;805(1-2):241-54 [9733975] Neurochem Int. 1998 Oct;33(4):359-66 [9840227] Biochem Pharmacol. 1999 Jan 1;57(1):111-20 [9920291] Trends Pharmacol Sci. 1999 Apr;20(4):142-50 [10322499] Brain Res Bull. 1999 Apr;48(6):641-7 [10386845] J Neurosci. 2005 Jan 5;25(1):29-41 [15634764] Neuropsychopharmacology. 2000 Jan;22(1):64-76 [10633492] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - What nephrologists need to know about gadolinium. AN - 68539586; 18033225 AB - Gadolinium chelates are commonly used to improve tissue contrast in MRI. Until recently the use of gadolinium was thought to be risk-free compared with alternative contrast agents. Recent studies, however, have raised serious concerns regarding the safety of gadolinium chelates. Although safe in patients with normal kidney function, administration of these agents in people with renal dysfunction can result in up to three clinical problems that the nephrologist should be familiar with. The first is nephrogenic systemic fibrosis (NSF), which was initially observed in 1997. Although manifesting primarily in skin, NSF can also cause systemic fibrosis, leading to disabling contractures and even death. Gadodiamide is the agent that has been most frequently associated with NSF, but other chelates might also pose a risk. The second clinical problem is that gadolinium chelates cause acute kidney injury, especially at high doses required for angiography. The third problem is that several laboratory artifacts are associated with gadolinium administration, with pseudohypocalcemia being the most important. The risk of a patient experiencing all three of these complications increases as renal function declines. In light of these problems, nephrologists need to re-evaluate the risks and benefits of gadolinium administration in patients with chronic kidney disease stage 3 or greater, as well as in those with acute kidney injury. JF - Nature clinical practice. Nephrology AU - Penfield, Jeffrey G AU - Reilly, Robert F AD - Section of Nephrology at Veterans Affairs North Texas Health Care System and Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75216, USA. jeffrey.penfield@va.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 654 EP - 668 VL - 3 IS - 12 KW - Gadolinium KW - AU0V1LM3JT KW - Index Medicus KW - Nephrology KW - Humans KW - Gadolinium -- adverse effects KW - Magnetic Resonance Imaging -- methods KW - Kidney Diseases -- diagnosis KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68539586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+clinical+practice.+Nephrology&rft.atitle=What+nephrologists+need+to+know+about+gadolinium.&rft.au=Penfield%2C+Jeffrey+G%3BReilly%2C+Robert+F&rft.aulast=Penfield&rft.aufirst=Jeffrey&rft.date=2007-12-01&rft.volume=3&rft.issue=12&rft.spage=654&rft.isbn=&rft.btitle=&rft.title=Nature+clinical+practice.+Nephrology&rft.issn=1745-8331&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-02 N1 - Date created - 2007-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic illness with complexity: implications for performance measurement of optimal glycemic control. AN - 68532326; 18026810 AB - To evaluate the association between chronic illness with complexity (CIC) and optimal glycemic control. Cross-sectional and longitudinal analyses of Diabetes Epidemiologic Cohort database of Veterans Health Administration (VHA) users with diabetes, less than 75 years old, with HbA1c tests in fiscal year (FY) 1999 and 2000, alive at FY2000 end (N = 95,423). Outcomes were HbA1c or= 7% in FY1999 and included hospitalizations between final HbA1c's in FY1999 and FY2000. Multiple logistic regressions examined associations between CIC categories and HbA1c. In FY1999, 33% had HbA1c <7%. In multivariate analyses, patients with nondiabetes physical illness and mental illness/substance abuse were more likely to have HbA1c <7% in FY1999 [adjusted odds ratios for cancer (AOR), 1.31; 95% CI (1.25-1.37); mental illness only, 1.18; 95% CI (1.14-1.22)]. Those with diabetes-related complications were less likely to have HbA1c <7% in FY1999. Associations generally held in FY2000. However, conditions in the mental illness/substance abuse complexity domain were less strongly associated with HbA1c <7%. Macrovascular-related hospitalizations were positively associated with HbA1c <7% [AOR, 1.41; 95% CI (1.34-1.49)]. The association between CIC and HbA1c <7% is heterogeneous and depends on the domain of complexity. The varying associations of CIC categories with optimal glycemic control suggest the need for appropriate risk adjustment when using HbA1c <7% as a valid performance measure for diabetes quality of care. JF - Journal of general internal medicine AU - Meduru, Pramod AU - Helmer, Drew AU - Rajan, Mangala AU - Tseng, Chin-Lin AU - Pogach, Leonard AU - Sambamoorthi, Usha AD - Center for Healthcare Knowledge Management, VA New Jersey Healthcare System, 385 Tremont Ave. (129), East Orange, NJ 07018, USA. pramod.meduru@va.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 408 EP - 418 VL - 22 Suppl 3 KW - Hemoglobin A, Glycosylated KW - 0 KW - Index Medicus KW - Humans KW - Aged KW - Substance-Related Disorders -- complications KW - Middle Aged KW - Mental Disorders -- complications KW - Male KW - Diabetes Complications KW - Hemoglobin A, Glycosylated -- analysis KW - Diabetes Mellitus -- blood KW - Chronic Disease KW - Comorbidity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68532326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+general+internal+medicine&rft.atitle=Chronic+illness+with+complexity%3A+implications+for+performance+measurement+of+optimal+glycemic+control.&rft.au=Meduru%2C+Pramod%3BHelmer%2C+Drew%3BRajan%2C+Mangala%3BTseng%2C+Chin-Lin%3BPogach%2C+Leonard%3BSambamoorthi%2C+Usha&rft.aulast=Meduru&rft.aufirst=Pramod&rft.date=2007-12-01&rft.volume=22+Suppl+3&rft.issue=&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=Journal+of+general+internal+medicine&rft.issn=1525-1497&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-14 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Diabetes Care. 2000 Jul;23(7):919-27 [10895841] Am J Manag Care. 2007 Mar;13(3):133-40 [17335354] Med Care. 2002 Feb;40(2):96-104 [11802082] Jt Comm J Qual Improv. 2002 Oct;28(10):555-65 [12369158] J Am Geriatr Soc. 2003 Apr;51(4):466-75 [12657065] J Am Geriatr Soc. 2003 May;51(5 Suppl Guidelines):S265-80 [12694461] Diabetes Care. 2003 Nov;26(11):3017-23 [14578233] Diabetes Care. 2003 Dec;26(12):3257-63 [14633811] Med Care. 2004 Feb;42(2 Suppl):II34-9 [14734940] Diabetes Care. 2004 May;27 Suppl 2:B10-21 [15113777] Am J Med Qual. 2004 May-Jun;19(3):112-20 [15212316] J Ambul Care Manage. 2004 Jul-Sep;27(3):281-95 [15287217] Ann Intern Med. 2004 Sep 21;141(6):421-31 [15381515] N Engl J Med. 1993 Sep 30;329(14):977-86 [8366922] Med Care. 1998 Jun;36(6):928-33 [9630133] Lancet. 1998 Sep 12;352(9131):837-53 [9742976] JAMA. 1999 Jun 2;281(21):2005-12 [10359389] Diabetes Care. 2005 Apr;28(4):950-5 [15793205] Health Serv Res. 2005 Dec;40(6 Pt 1):1818-35 [16336550] Arch Intern Med. 2005 Dec 12-26;165(22):2631-8 [16344421] Diabetes Care. 2006 Jan;29 Suppl 1:S4-42 [16373931] Diabetes Care. 2006 Mar;29(3):725-31 [16505540] BMC Health Serv Res. 2006;6:58 [16716235] Med Care. 2006 Aug;44(8):768-73 [16862039] Qual Life Res. 2007 Mar;16(2):165-77 [17033903] JAMA. 2007 Feb 7;297(5):520-3 [17284702] Diabetes Care. 2001 Sep;24(9):1547-55 [11522697] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Veterans Affairs facility performance on Washington Circle indicators and casemix-adjusted effectiveness. AN - 68491945; 17400416 AB - Self-administered Addiction Severity Index (ASI) data were collected on 5,723 patients who received substance abuse treatment in 1 of 110 programs located at 73 Veterans Affairs facilities. The associations between each of three Washington Circle (WC) performance indicator scores (identification, initiation, and engagement) and their casemix-adjusted facility-level improvement in ASI drug and alcohol composites 7 months after intake were estimated. Higher initiation rates were not associated with facility-level improvement in ASI alcohol composite scores but were modestly associated with greater improvements in ASI drug composite scores. Identification and engagement rates were unrelated to 7-month outcomes. WC indicators focused on the early stages of treatment may tap necessary but insufficient processes for patients with substance use disorder to achieve good posttreatment outcomes. Ideally, the WC indicators would be supplemented with other measures of treatment quality. JF - Journal of substance abuse treatment AU - Harris, Alex H S AU - Humphreys, Keith AU - Finney, John W AD - Center for Health Care Evaluation, Department of Veterans Affairs Palo Alto Health Care System, Menlo Park, CA 94025, USA. Alexander.Harris2@va.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 333 EP - 339 VL - 33 IS - 4 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Veterans KW - Severity of Illness Index KW - Humans KW - Substance-Related Disorders -- therapy KW - Risk Adjustment KW - Alcoholism -- therapy KW - Outcome Assessment (Health Care) KW - Substance Abuse Treatment Centers -- standards KW - Quality Assurance, Health Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68491945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Veterans+Affairs+facility+performance+on+Washington+Circle+indicators+and+casemix-adjusted+effectiveness.&rft.au=Harris%2C+Alex+H+S%3BHumphreys%2C+Keith%3BFinney%2C+John+W&rft.aulast=Harris&rft.aufirst=Alex+H&rft.date=2007-12-01&rft.volume=33&rft.issue=4&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-17 N1 - Date created - 2007-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Subst Abuse Treat. 2007 Dec;33(4):353-4 [17596902] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancer treatment-induced bone loss. AN - 68471184; 17982349 AB - Patients treated for cancer may be at risk for osteoporosis and fracture. Evaluation and treatment of patients with cancer treatment-induced bone loss should lead to fewer fractures. This review will help clinicians learn to identify, evaluate and treat cancer patients at risk. Survivors of childhood cancers and patients made hypogonadal by treatment for breast or prostate cancer are clearly at risk for osteoporosis and fracture. Use of aromatase inhibitors rather than tamoxifen for breast cancer will likely lead to more osteoporosis. Bisphosphonates prevent bone loss in many patients at risk. For many cancer patients, treatment with calcium, vitamin D, and bisphosphonates will likely decrease the consequences of cancer treatment-induced bone loss, namely fractures. JF - Current opinion in endocrinology, diabetes, and obesity AU - Adler, Robert A AD - McGuire Veterans Affairs Medical Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23249, USA. robert.adler@va.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 442 EP - 445 VL - 14 IS - 6 KW - Androgen Antagonists KW - 0 KW - Antineoplastic Agents, Hormonal KW - Bone Density Conservation Agents KW - Diphosphonates KW - Estrogen Receptor Modulators KW - Index Medicus KW - Breast Neoplasms -- drug therapy KW - Diphosphonates -- therapeutic use KW - Age Factors KW - Androgen Antagonists -- adverse effects KW - Bone Density Conservation Agents -- therapeutic use KW - Risk Factors KW - Humans KW - Prostatic Neoplasms -- drug therapy KW - Estrogen Receptor Modulators -- adverse effects KW - Survivors KW - Male KW - Female KW - Risk Assessment KW - Neoplasms -- drug therapy KW - Fractures, Bone -- prevention & control KW - Osteoporosis -- diagnosis KW - Fractures, Bone -- etiology KW - Osteoporosis -- etiology KW - Osteoporosis -- drug therapy KW - Hypogonadism -- complications KW - Antineoplastic Agents, Hormonal -- adverse effects KW - Osteoporosis -- complications KW - Hypogonadism -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68471184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+endocrinology%2C+diabetes%2C+and+obesity&rft.atitle=Cancer+treatment-induced+bone+loss.&rft.au=Adler%2C+Robert+A&rft.aulast=Adler&rft.aufirst=Robert&rft.date=2007-12-01&rft.volume=14&rft.issue=6&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+endocrinology%2C+diabetes%2C+and+obesity&rft.issn=1752-2978&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-18 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Discrepancies between self-report and objective measures for stimulant drug use in HIV: cognitive, medication adherence and psychological correlates. AN - 68330968; 17499443 AB - While it has long been recognized that self-reported drug use may be at variance with objectively obtained evidence such as urine toxicology assays, few studies have explored the behavioral correlates of such discrepancies. Here we compared self-reported and objective measures of stimulant drug use for 162 HIV infected individuals and identified a sub-group with discrepancies between data obtained via the two methods. Results showed poorer neurocognitive performance (attention, learning/memory) and lower medication adherence rates for the discrepant group as compared to those who either acknowledged their drug use or accurately denied recent stimulant use. Using the Millon Clinical Multiaxial Inventory-III, it was also found that those in the discrepant group were more hesitant to reveal psychopathology. Comparisons of self-reported and objectively measured medication adherence data are also discussed. JF - Addictive behaviors AU - Reinhard, M J AU - Hinkin, C H AU - Barclay, T R AU - Levine, A J AU - Marion, S AU - Castellon, S A AU - Longshore, D AU - Newton, T AU - Durvasula, R S AU - Lam, M N AU - Myers, H AD - matthew.reinhard@va.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2727 EP - 2736 VL - 32 IS - 12 SN - 0306-4603, 0306-4603 KW - Central Nervous System Stimulants KW - 0 KW - Index Medicus KW - Surveys and Questionnaires -- standards KW - Self Disclosure KW - Medical Records KW - Analysis of Variance KW - Data Collection -- methods KW - Humans KW - Adult KW - Health Knowledge, Attitudes, Practice KW - Male KW - Female KW - Substance-Related Disorders -- diagnosis KW - Patient Compliance -- statistics & numerical data KW - HIV Infections -- drug therapy KW - Substance-Related Disorders -- psychology KW - HIV Infections -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68330968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Discrepancies+between+self-report+and+objective+measures+for+stimulant+drug+use+in+HIV%3A+cognitive%2C+medication+adherence+and+psychological+correlates.&rft.au=Reinhard%2C+M+J%3BHinkin%2C+C+H%3BBarclay%2C+T+R%3BLevine%2C+A+J%3BMarion%2C+S%3BCastellon%2C+S+A%3BLongshore%2C+D%3BNewton%2C+T%3BDurvasula%2C+R+S%3BLam%2C+M+N%3BMyers%2C+H&rft.aulast=Reinhard&rft.aufirst=M&rft.date=2007-12-01&rft.volume=32&rft.issue=12&rft.spage=2727&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: AIDS Care. 2000 Jun;12(3):255-66 [10928201] Am J Addict. 2000 Summer;9(3):216-21 [11000917] Drug Alcohol Depend. 2000 Apr 1;59(1):43-9 [10706974] Drug Alcohol Depend. 2000 Feb 1;58(1-2):111-6 [10669061] J Clin Exp Neuropsychol. 2006 Jan;28(1):29-42 [16448974] Am J Psychiatry. 2005 Feb;162(2):361-9 [15677602] Drug Alcohol Depend. 1998 Aug 1;51(3):253-63; discussion 267-8 [9787998] JAMA. 1998 Jun 24;279(24):1977-83 [9643862] N Engl J Med. 1994 Nov 24;331(21):1422-7 [7969281] Exp Clin Psychopharmacol. 1997 May;5(2):150-6 [9234052] Health Psychol. 2006 May;25(3):329-35 [16719604] J Neuropsychiatry Clin Neurosci. 1993 Fall;5(4):419-27 [8286941] Alcohol Clin Exp Res. 1993 Aug;17(4):758-61 [8214409] Am J Prev Med. 1993 Jan-Feb;9(1):62-4 [8439442] Percept Mot Skills. 1991 Oct;73(2):539-50 [1766784] Arch Intern Med. 1988 Nov;148(11):2407-12 [3056313] Addiction. 2004 May;99(5):590-7 [15078233] AIDS. 2004 Jan 1;18 Suppl 1:S19-25 [15075494] Addiction. 2004 Feb;99(2):197-208 [14756712] J Int Neuropsychol Soc. 2004 Jan;10(1):1-14 [14751002] Int J STD AIDS. 2003 Apr;14(4):281-4 [12716500] J Acquir Immune Defic Syndr. 2002 Dec 15;31 Suppl 3:S103-6 [12562030] J Drug Educ. 2002;32(4):261-70 [12556132] Am J Drug Alcohol Abuse. 2001 Aug;27(3):399-419 [11506259] Ann Intern Med. 2001 May 15;134(10):968-77 [11352698] AIDS. 2000 Mar 10;14(4):357-66 [10770537] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Issues Regarding the Clinical Use of the Classification of Violence Risk (COVR) Assessment Instrument AN - 61705305; 200811931 AB - The MacArthur Study of Mental Disorder and Violence produced an instrument for classifying hospitalized psychiatric patients according to their risk of behaving violently following discharge. The instrument, Classification of Violence Risk (COVR) has been computerized and is now commercially available to clinicians. A validation study performed by the original researchers showed that when the instrument was applied to a new sample of patients, it demonstrated a considerable reduction in positive predictive power. Potential factors affecting the instrument's accuracy in applied settings are reviewed. It is concluded that, until additional research clarifies uncertainty about the instrument, clinicians would do well to be very cautious in utilizing COVR results to make judgments as to violence risk, particularly when the test results suggest a high risk of future violence. [Reprinted by permission of Sage Publications Inc., copyright 2007.] JF - International Journal of Offender Therapy and Comparative Criminology AU - McCusker, Paul J AD - Department of Veterans A fairs, Cumberland, MD paul.mccusker@va.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 676 EP - 685 PB - Sage Publications, Thousand Oaks CA VL - 51 IS - 6 SN - 0306-624X, 0306-624X KW - Certainty KW - Risk KW - Mental Patients KW - Validity KW - Mental Illness KW - Violence KW - article KW - 2147: social problems and social welfare; sociology of crime UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61705305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Offender+Therapy+and+Comparative+Criminology&rft.atitle=Issues+Regarding+the+Clinical+Use+of+the+Classification+of+Violence+Risk+%28COVR%29+Assessment+Instrument&rft.au=McCusker%2C+Paul+J&rft.aulast=McCusker&rft.aufirst=Paul&rft.date=2007-12-01&rft.volume=51&rft.issue=6&rft.spage=676&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Offender+Therapy+and+Comparative+Criminology&rft.issn=0306624X&rft_id=info:doi/10.1177%2F0306624X07299227 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-05-02 N1 - Number of references - 21 N1 - Last updated - 2016-09-28 N1 - CODEN - IOTCAH N1 - SubjectsTermNotLitGenreText - Validity; Violence; Mental Illness; Risk; Certainty; Mental Patients DO - http://dx.doi.org/10.1177/0306624X07299227 ER - TY - JOUR T1 - Hierarchical linear modeling (HLM) of longitudinal brain structural and cognitive changes in alcohol-dependent individuals during sobriety AN - 57250958; 200810529 AB - Background: Hierarchical linear modeling (HLM) can reveal complex relationships between longitudinal outcome measures and their covariates under proper consideration of potentially unequal error variances. We demonstrate the application of HLM to the study of magnetic resonance imaging (MRI)-derived brain volume changes and cognitive changes in abstinent alcohol-dependent individuals as a function of smoking status, smoking severity, and drinking quantities. Methods Twenty non-smoking recovering alcoholics (nsALC) and 30 age-matched smoking recovering alcoholics (sALC) underwent quantitative MRI and cognitive assessments at 1 week, 1 month, and 7 months of sobriety. Eight non-smoking light drinking controls were studied at baseline and 7 months later. Brain and ventricle volumes at each time point were quantified using MRI masks, while the boundary shift integral method measured volume changes between time points. Using HLM, we modeled volumetric and cognitive outcome measures as a function of cigarette and alcohol use variables. Results Different hierarchical linear models with unique model structures are presented and discussed. The results show that smaller brain volumes at baseline predict faster brain volume gains, which were also related to greater smoking and drinking severities. Over 7 months of abstinence from alcohol, sALC compared to nsALC showed less improvements in visuospatial learning and memory despite larger brain volume gains and ventricular shrinkage. Conclusions Different and unique hierarchical linear models allow assessments of the complex relationships among outcome measures of longitudinal data sets. These HLM applications suggest that chronic cigarette smoking modulates the temporal dynamics of brain structural and cognitive changes in alcoholics during prolonged sobriety. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Yeh, Ping-Hong AU - Gazdzinski, Stefan AU - Durazzo, Timothy C AU - Sjostrand, Karl AU - Meyerhoff, Dieter J AD - Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, United States ping-hong.yeh@ucsf.edu Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 195 EP - 204 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 91 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Hierarchical linear models KW - Boundary shift integral KW - Brain MRI KW - Alcoholism KW - Smoking KW - Cognition KW - Cognitive change KW - Sobriety KW - Magnetic resonance imaging KW - Brain KW - Alcoholics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57250958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Hierarchical+linear+modeling+%28HLM%29+of+longitudinal+brain+structural+and+cognitive+changes+in+alcohol-dependent+individuals+during+sobriety&rft.au=Yeh%2C+Ping-Hong%3BGazdzinski%2C+Stefan%3BDurazzo%2C+Timothy+C%3BSjostrand%2C+Karl%3BMeyerhoff%2C+Dieter+J&rft.aulast=Yeh&rft.aufirst=Ping-Hong&rft.date=2007-12-01&rft.volume=91&rft.issue=2-3&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.05.027 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Brain; Smoking; Alcoholics; Sobriety; Cognitive change; Magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.05.027 ER - TY - JOUR T1 - Use of Preventive Care by Elderly Male Veterans Receiving Care Through the Veterans Health Administration, Medicare Fee-for-Service, and Medicare HMO Plans AN - 21348727; 7928558 AB - OBJECTIVES: We compared use of preventive care among veterans receiving care through the Veterans Health Administration (VHA), Medicare fee-for-service (FFS) plans, and Medicare health maintenance organizations (HMOs). METHODS: Using both the Costs and Use, and Access to Care files of the Medicare Current Beneficiary Survey (2000-2003), we performed a cross-sectional analysis examining self-reported use of influenza vaccination, pneumococcal vaccination, serum cholesterol screening, and serum prostate-specific antigen measurement among male veterans 65 years or older. Veterans' care was categorized as received through VHA, Medicare FFS, Medicare HMOs, VHA and Medicare FFS, or VHA and Medicare HMOs. RESULTS: Veterans receiving care through VHA reported 10% greater use of influenza vaccination (P<.05), 14% greater use of pneumococcal vaccination (P<.01), a nonsignificant 6% greater use of serum cholesterol screening (P=.1), and 15% greater use of prostate cancer screening (P<.01) than did veterans receiving care through Medicare HMOs. Veterans receiving care through Medicare FFS reported less use of all 4 preventive measures (P<.01) than did veterans receiving care through Medicare HMOs. CONCLUSIONS: Receiving care through VHA was associated with greater use of preventive care. JF - American Journal of Public Health AU - Keyhani, Salomeh AU - Ross, Joseph S AU - Hebert, Paul AU - Dellenbaugh, Cornelia AU - Penrod, Joan D AU - Siu, Albert L AD - Salomeh Keyhani is with the Health Services Research and Development (HSR&D) Targeted Research Enhancement Program, James J. Peters Veterans Administration Medical Center, New York, NY, and the Department of Health Policy, Mount Sinai School of Medicine, New York, NY. Joseph S. Ross, Cornelia Dellenbaugh, Joan D. Penrod, and Albert L. Siu are with the HSR&D Targeted Research Enhancement Program, James J. Peters Veterans Administration Medical Center, New York, and the Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York. Paul Hebert is with the Department of Health Policy, Mount Sinai School of Medicine, New York Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2179 EP - 2185 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 12 SN - 0090-0036, 0090-0036 KW - Microbiology Abstracts B: Bacteriology KW - Influenza KW - Streptococcus pneumoniae KW - Prostate cancer KW - Geriatrics KW - Cholesterol KW - Vaccination KW - prostate-specific antigen KW - Public health KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21348727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Use+of+Preventive+Care+by+Elderly+Male+Veterans+Receiving+Care+Through+the+Veterans+Health+Administration%2C+Medicare+Fee-for-Service%2C+and+Medicare+HMO+Plans&rft.au=Keyhani%2C+Salomeh%3BRoss%2C+Joseph+S%3BHebert%2C+Paul%3BDellenbaugh%2C+Cornelia%3BPenrod%2C+Joan+D%3BSiu%2C+Albert+L&rft.aulast=Keyhani&rft.aufirst=Salomeh&rft.date=2007-12-01&rft.volume=97&rft.issue=12&rft.spage=2179&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Influenza; Prostate cancer; Geriatrics; Cholesterol; prostate-specific antigen; Vaccination; Public health; Streptococcus pneumoniae ER - TY - JOUR T1 - Performance Measures, Vaccinations, and Pneumonia Rates Among High-Risk Patients in Veterans Administration Health Care AN - 20727010; 7928556 AB - OBJECTIVES: Influenza and pneumococcal vaccinations reduce morbidity, mortality, and health care costs, but their use lags behind goals set by public health experts. We evaluated the effect of a performance measurement program instituted by the Veterans Health Administration in 1995 to improve vaccination rates. METHODS: We used cross-sectional chart-abstracted data to calculate influenza and pneumococcal vaccination rates among eligible patients, and administrative data to calculate pneumonia admission rates. We compared vaccination and hospitalization rates before and after the institution of the performance measurement program with rates outside the Veterans Health Administration. RESULTS: Influenza and pneumococcal vaccination rates for eligible patients rose from 27% and 28% during 1994 to 1995 to 70% and 85%, respectively, by 2003 (P for trend<.001). Geographic and other variations were substantially reduced. During this time, pneumonia hospitalization rates decreased by 50% among elderly Veterans Health Administration enrollees but increased among Medicare enrollees by 15% (P for differences in trend<.001). CONCLUSIONS: The performance measurement program was associated with increases in vaccination rates, reduced variation, and reduced pneumonia admissions. Health systems instituting similarly effective programs may substantially improve the quality of their clinical health care. JF - American Journal of Public Health AU - Jha, Ashish K AU - Wright, Steven M AU - Perlin, Jonathan B AD - At the time of the study, Ashish K. Jha was with the Harvard School of Public Health, Boston, Mass, and the Veterans Administration Boston Healthcare System, Boston. Steven M. Wright was with the Office of Quality and Performance, Veterans Health Administration, Washington, DC. Jonathan B. Perlin was with the Office of the Under Secretary of Health, Veterans Health Administration, Washington, DC Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2167 EP - 2172 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 12 SN - 0090-0036, 0090-0036 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - Mortality KW - Data processing KW - Vaccination KW - Morbidity KW - influenza KW - Public health KW - Influenza KW - Streptococcus pneumoniae KW - Health care KW - Geriatrics KW - Risk groups KW - elderly KW - Pneumonia KW - J 02350:Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Performance+Measures%2C+Vaccinations%2C+and+Pneumonia+Rates+Among+High-Risk+Patients+in+Veterans+Administration+Health+Care&rft.au=Jha%2C+Ashish+K%3BWright%2C+Steven+M%3BPerlin%2C+Jonathan+B&rft.aulast=Jha&rft.aufirst=Ashish&rft.date=2007-12-01&rft.volume=97&rft.issue=12&rft.spage=2167&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Influenza; Mortality; Data processing; Geriatrics; Risk groups; Vaccination; Morbidity; Pneumonia; Public health; Health care; elderly; influenza; Streptococcus pneumoniae ER - TY - JOUR T1 - The Veterans Health Administration and Military Sexual Trauma AN - 20588910; 7928555 AB - OBJECTIVES: We examined the utility of the Veterans Health Administration (VHA) universal screening program for military sexual violence. METHODS: We analyzed VHA administrative data for 185 880 women and 4139888 men who were veteran outpatients and were treated in VHA health care settings nationwide during 2003. RESULTS: Screening was completed for 70% of patients. Positive screens were associated with greater odds of virtually all categories of mental health comorbidities, including posttraumatic stress disorder (adjusted odds ratio [AOR]=8.83; 99% confidence interval [CI] = 8.34, 9.35 for women; AOR = 3.00; 99% CI = 2.89, 3.12 for men). Associations with medical comorbidities (e.g., chronic pulmonary disease, liver disease, and for women, weight conditions) were also observed. Significant gender differences emerged. CONCLUSIONS: The VHA policies regarding military sexual trauma represent a uniquely comprehensive health care response to sexual trauma. Results attest to the feasibility of universal screening, which yields clinically significant information with particular relevance to mental health and behavioral health treatment. Women's health literature regarding sexual trauma will be particularly important to inform health care services for both male and female veterans. JF - American Journal of Public Health AU - Kimerling, Rachel AU - Gima, Kristian AU - Smith, Mark W AU - Street, Amy AU - Frayne, Susan AD - Rachel Kimerling and Kristian Gima are with the Veterans Administration Health Care System, Palo Alto, Calif. Mark W. Smith and Susan Frayne are with the Veterans Administration Health Care System, Palo Alto, and also with the Center for Primary Care and Outcomes Research at the Stanford University School of Medicine, Palo Alto. Susan Frayne is also with the Division of General Internal Medicine, Department of Medicine, at Stanford University, Palo Alto. Amy Street is with the Veterans Administration Health Care System in Boston, Mass, and the Department of Psychiatry, Boston University School of Medicine, Boston Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2160 EP - 2166 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 12 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts; Health & Safety Science Abstracts KW - Feasibility studies KW - Psychology KW - Occupational safety KW - Gender KW - Military KW - sexual assault KW - Morbidity KW - Public health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20588910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=The+Veterans+Health+Administration+and+Military+Sexual+Trauma&rft.au=Kimerling%2C+Rachel%3BGima%2C+Kristian%3BSmith%2C+Mark+W%3BStreet%2C+Amy%3BFrayne%2C+Susan&rft.aulast=Kimerling&rft.aufirst=Rachel&rft.date=2007-12-01&rft.volume=97&rft.issue=12&rft.spage=2160&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Feasibility studies; Psychology; Gender; Occupational safety; Military; sexual assault; Morbidity; Public health ER - TY - JOUR T1 - Analysis of Cartilage Tissue on a Cellular Level in Fresh Osteochondral Allograft Retrievals AN - 20552767; 7928822 AB - BACKGROUND: Fresh human osteochondral allografting is a biological cartilage replacement technique used to treat articular and osteoarticular defects in the knee. A small number of grafts fail, and we analyzed every retrieved graft during a 4-year period in order to learn more about the potential causes of failure. HYPOTHESIS: A large percentage of chondrocytes still remain viable many years after fresh osteochondral allografting. STUDY DESIGN: Descriptive laboratory study. METHODS: Retrieval specimens were obtained at the time of revision surgery and immediately analyzed. Chondrocyte viability and viable cell density were determined using a live/dead staining technique followed by confocal microscopy. Glycosaminoglycan content was a measure of the cartilage matrix. Radiolabeled sulfate uptake served as a biochemical marker of chondrocyte metabolic activity. Cartilage and subchondral bone were examined histologically. RESULTS: Fourteen patients yielded a total of 26 retrieval specimens that had been originally implanted as individual fresh osteochondral allografts. Average graft survival was 42 months. Chondrocyte viability was 82% plus or minus 17%, and chondrocyte viable cell density was 15 590 plus or minus 5900 viable cells/mm super(3). Retrieved tissue demonstrated radiolabeled sulfate uptake of 437 plus or minus 270 counts per minute and 3.5% plus or minus 0.8% hexosamine per dry weight. Histologically, all specimens showed some degree of cartilage fibrillation. There was evidence of bone allograft incorporation in most specimens, as well as pannus formation in 4 specimens, but no evidence of immune rejection. CONCLUSION: A small percentage of fresh osteochondral allografts fail, but the precise cause is unknown. The main theories for failure investigated here include immunologic rejection, failure of bony incorporation, and chondrocyte death causing breakdown of the cartilage matrix. We show that chondrocytes remain viable many years after transplantation, allograft bone incorporates, and immune rejection does not seem to play a primary role in failure. Clinical Relevance: Fresh osteochondral allografting is becoming more common in the treatment of articular cartilage defects in the knee. Our findings support the paradigm of fresh osteochondral allografting, the transplantation of hyaline cartilage with biological incorporation of the underlying bone scaffold. The reasons for failure of a small percentage of grafts remain unclear. JF - American Journal of Sports Medicine AU - Williams, Seth K AU - Amiel, David AU - Ball, Scott T AU - Allen, RTodd AU - Tontz, William LJr AU - Emmerson, Bryan C AU - Badlani, Neil M AU - Emery, Shawn C AU - Haghighi, Parviz AU - Bugbee, William D AD - Department of Orthopaedic Surgery, University of California, San Diego, La Jolla, California, and the Department of Pathology, Veterans Administration Medical Center, San Diego, La Jolla, California Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2022 EP - 2032 PB - American Orthopaedic Society of Sports Medicine, 230 Calvary Street Waltham MA 02453 USA, [URL:http://www.sportsmed.org/default.htm] VL - 35 IS - 12 SN - 0363-5465, 0363-5465 KW - Physical Education Index; Calcium & Calcified Tissue Abstracts KW - Biochemical markers KW - Death KW - Bones KW - Graft rejection KW - Cartilage KW - Cell density KW - Bone grafts KW - Knees KW - Chondrocytes KW - Techniques KW - Sports KW - Glycosaminoglycans KW - Weight KW - Surgery KW - Allografts KW - Bone (subchondral) KW - Organ transplants KW - Failure KW - Cartilage (articular) KW - Patients KW - Pannus KW - Knee KW - scaffolds KW - Sulfate KW - Fibrillation KW - Analysis KW - Confocal microscopy KW - Sports medicine KW - T 2030:Cartilage and Cartilage Diseases KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20552767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Analysis+of+Cartilage+Tissue+on+a+Cellular+Level+in+Fresh+Osteochondral+Allograft+Retrievals&rft.au=Williams%2C+Seth+K%3BAmiel%2C+David%3BBall%2C+Scott+T%3BAllen%2C+RTodd%3BTontz%2C+William+LJr%3BEmmerson%2C+Bryan+C%3BBadlani%2C+Neil+M%3BEmery%2C+Shawn+C%3BHaghighi%2C+Parviz%3BBugbee%2C+William+D&rft.aulast=Williams&rft.aufirst=Seth&rft.date=2007-12-01&rft.volume=35&rft.issue=12&rft.spage=2022&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Death; Bones; Weight; Surgery; Analysis; Cartilage; Knees; Organ transplants; Techniques; Failure; Patients; Sports medicine; Biochemical markers; Graft rejection; Cell density; Bone grafts; Chondrocytes; Sports; scaffolds; Knee; Sulfate; Glycosaminoglycans; Fibrillation; Confocal microscopy; Allografts; Bone (subchondral); Cartilage (articular); Pannus ER - TY - JOUR T1 - Factors Associated With Patients Who Leave Acute-Care Hospitals Against Medical Advice AN - 20526689; 7928562 AB - OBJECTIVES: We examined hospital- and patient-related factors associated with discharge against medical advice (termed self-discharge) after emergency admission to acute-care hospitals. METHODS: We analyzed data from the Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project using logistic regression models to assess the relationship between self-discharge and a set of patient and hospital characteristics. RESULTS: Of 3 039 050 discharges in the sample, 43 678 were against medical advice (1.44%). In multivariable modeling, predictors of self-discharge included having Medicaid insurance (adjusted odds ratio [AOR]=3.32; 95% confidence interval [CI]=3.22, 3.42), having Medicare insurance (AOR=1.64; 95% CI=1.59, 1.70), urban location (AOR=1.66; 95% CI=1.61, 1.72), medium (AOR=1.25; 95% CI=1.20, 1.29) or large (AOR=1.08, 95% CI=1.05, 1.12) hospital (defined by the number of beds), shorter hospital stay (OR=0.84; 95% CI=0.84, 0.85), and African American race (AOR=1.10; 95% CI=1.07, 1.14). Teaching hospitals had fewer self-discharges (AOR=0.90; 95% CI=0.88, 0.92). Other predictors of discharge against medical advice included age, gender, and income. CONCLUSIONS: Approximately 1 in 70 hospital discharges in the United States are against medical advice. Both hospital and patient characteristics were associated with these decisions. JF - American Journal of Public Health AU - Ibrahim, Said A AU - Kwoh, CKent AU - Krishnan, Eswar AD - Said A. Ibrahim is with the Center for Health Equity Research and Promotion, Veterans Administration Pittsburgh Healthcare System, Pittsburgh, Pa. C. Kent Kwoh is with the Center for Health Equity Research and Promotion, Veterans Administration Pittsburgh Healthcare System, Pittsburgh, and the Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh. Eswar Krishnan is with the Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2204 EP - 2208 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 12 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20526689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Factors+Associated+With+Patients+Who+Leave+Acute-Care+Hospitals+Against+Medical+Advice&rft.au=Ibrahim%2C+Said+A%3BKwoh%2C+CKent%3BKrishnan%2C+Eswar&rft.aulast=Ibrahim&rft.aufirst=Said&rft.date=2007-12-01&rft.volume=97&rft.issue=12&rft.spage=2204&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Reducing Avoidable Deaths Among Veterans: Directing Private-Sector Surgical Care to High-Performance Hospitals AN - 20526631; 7928559 AB - OBJECTIVES: We quantified older (65 years and older) Veterans Health Administration (VHA) patients' use of the private sector to obtain 14 surgical procedures and assessed the potential impact of directing that care to high-performance hospitals. METHODS: Using a merged VHA-Medicare inpatient database for 2000 and 2001, we determined where older VHA enrollees obtained 6 cardiovascular surgeries and 8 cancer resections and whether private-sector care was obtained in high- or low-performance hospitals (based on historical performance and determined 2 years in advance of the service year). We then modeled the mortality and travel burden effect of directing private-sector care to high-performance hospitals. RESULTS: Older veterans obtained most of their procedures in the private sector, but that care was equally distributed across high- and low-performance hospitals. Directing private-sector care to high-performance hospitals could have led to the avoidance of 376 to 584 deaths, most through improved cardiovascular care outcomes. Using historical mortality to define performance would produce better outcomes with lower travel time. CONCLUSIONS: Policy that directs older VHA enrollees' private-sector care to high-performance hospitals promises to reduce mortality for VHA's service population and warrants further exploration. JF - American Journal of Public Health AU - Weeks, William B AU - West, Alan N AU - Wallace, Amy E AU - Lee, Richard E AU - Goodman, David C AU - Dimick, Justin B AU - Bagian, James P AD - William B. Weeks is with the Veterans Administration (VA) Outcomes Group Research Enhancement Award Program, VA Medical Center, White River Junction, Vt, and the Department of Psychiatry, Dartmouth Medical School, and the Dartmouth Institute for Health Policy and Clinical Practice, Hanover, NH. Alan N. West and Richard E. Lee are with the VA Outcomes Group Research Enhancement Award Program, VA Medical Center, White River Junction. Amy E. Wallace is with the VA Outcomes Group Research Enhancement Award Program, VA Medical Center, White River Junction, and the Department of Psychiatry, Dartmouth Medical School, Hanover. David C. Goodman is with the Department of Pediatrics, Dartmouth Medical School, and the Dartmouth Institute for Health Policy and Clinical Practice, Hanover. Justin B. Dimick is with the VA Outcomes Group Research Enhancement Award Program, VA Medical Center, White River Junction, and the Department of Surgery, University of Michigan, Ann Arbor. James P. Bagian is with the Veterans Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2186 EP - 2192 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 12 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20526631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Reducing+Avoidable+Deaths+Among+Veterans%3A+Directing+Private-Sector+Surgical+Care+to+High-Performance+Hospitals&rft.au=Weeks%2C+William+B%3BWest%2C+Alan+N%3BWallace%2C+Amy+E%3BLee%2C+Richard+E%3BGoodman%2C+David+C%3BDimick%2C+Justin+B%3BBagian%2C+James+P&rft.aulast=Weeks&rft.aufirst=William&rft.date=2007-12-01&rft.volume=97&rft.issue=12&rft.spage=2186&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - The Evolution of Changes in Primary Care Delivery Underlying the Veterans Health Administration's Quality Transformation AN - 20526239; 7928554 AB - OBJECTIVES: Suffering from waning demand, poor quality, and reform efforts enabling veterans to "vote with their feet" and leave, the Veterans Health Administration (VA) health care system transformed itself through a series of substantive changes. We examined the evolution of primary care changes underlying VA's transformation. METHODS: We used 3 national organizational surveys from 1993, 1996, and 1999 that measured primary care organization, staffing, management, and resource sufficiency to evaluate changes in VA primary care delivery. RESULTS: Only rudimentary primary care was in place in 1993. Primary care enrollment grew from 38% in 1993 to 45% in 1996, and to 95% in 1999 as VA adopted team structures and increased the assignment of patients to individual providers. Specialists initially staffed primary care until generalist physicians and nonphysican providers increased. Primary care-based quality improvement and authority expanded, and resource sufficiency (e.g., computers, space) grew. Provider notification of admissions and emergency department, urgent-care visit, and sub-specialty-consult results increased nearly 5 times. CONCLUSIONS: Although VA's quality transformation had many underlying causes, investment in primary care development may have served as an essential substrate for many VA quality gains. JF - American Journal of Public Health AU - Yano, Elizabeth M AU - Simon, Barbara F AU - Lanto, Andrew B AU - Rubenstein, Lisa V AD - Elizabeth M. Yano is with the Veterans Health Administration Greater Los Angeles Health Services Research and Development (HSR&D) Center of Excellence, Los Angeles, Calif, and the School of Public Health, University of California, Los Angeles. Barbara F. Simon and Andrew B. Lanto are with the Veterans Health Administration Greater Los Angeles HSR&D Center of Excellence, Los Angeles, California. Lisa V. Rubenstein is with the Veterans Health Administration Greater Los Angeles HSR&D Center of Excellence, Los Angeles, and RAND Health, Santa Monica, Calif Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2151 EP - 2159 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 12 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20526239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=The+Evolution+of+Changes+in+Primary+Care+Delivery+Underlying+the+Veterans+Health+Administration%27s+Quality+Transformation&rft.au=Yano%2C+Elizabeth+M%3BSimon%2C+Barbara+F%3BLanto%2C+Andrew+B%3BRubenstein%2C+Lisa+V&rft.aulast=Yano&rft.aufirst=Elizabeth&rft.date=2007-12-01&rft.volume=97&rft.issue=12&rft.spage=2151&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Induction of multiple antibiotic resistance in Bacteroides fragilis by benzene and benzene-derived active compounds of commonly used analgesics, antiseptics and cleaning agents AN - 20435093; 7741477 AB - OBJECTIVES: To determine the potential of active compounds (ACs) present in commonly used analgesics/antiseptics and cleaning agents (detergents and disinfectants) to induce multiple antibiotic resistance (MAR) in Bacteroides fragilis. METHODS: B. fragilis ATCC 25285 untreated or pretreated with sublethal concentrations of ACs (n = 25) was grown for 12 h. Susceptibility of cells pre-treated with various ACs to antibiotics and expression of resistance nodulation division family (bmeB) efflux pumps and putative marA-like global activators (PGAs) were measured. RESULTS: Twelve aromatic ACs containing benzene or its activated derivatives (salicylate, acetaminophen, gingerol, benzoate, phenol, chlorhexidine gluconate, capsaicin, juglone, cinnamaldehyde, benzene, ibuprofen and Triton X-100) induced MAR, which was reduced by carbonyl cyanide m-chlorophenylhydrazone. There was a positive correlation between the predicted degree of benzene activation and the level of induction. Deactivated benzene or non-aromatic ACs were either poor inducers or non-inducers. Efflux pumps bmeB1, 3, 4, 7 and two PGAs bfrA1 and bfrA2 were overexpressed. Expression of bfrA1 or bfrA2 in Escherichia coli caused a >2-fold increase in the MAR and overexpression of acrB, suggesting that they were putative marA orthologues. CONCLUSIONS: These data demonstrate (i) the presence of an MarA-like system(s) in B. fragilis and (ii) the propensity of benzene or its activated derivatives present in pharmaceutical products to induce MAR. JF - Journal of Antimicrobial Chemotherapy AU - Pumbwe, Lilian AU - Skilbeck, Christopher A AU - Wexler, Hannah M AD - Greater Los Angeles Veterans Administration Healthcare Systems, University of California, Los Angeles, CA, USA. Department of Medicine, University of California, Los Angeles, CA, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1288 EP - 1297 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 60 IS - 6 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Bacteroides fragilis KW - Ibuprofen KW - Benzoic acid KW - Chlorhexidine KW - Detergents KW - cinnamaldehyde KW - Salicylic acid KW - Capsaicin KW - Phenols KW - Benzene KW - Disinfectants KW - Cyanide KW - Antiseptics KW - Escherichia coli KW - Nodulation KW - Pharmaceuticals KW - Analgesics KW - carbonyls KW - Aromatics KW - Acetaminophen KW - Antibiotic resistance KW - A 01350:Microbial Resistance KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20435093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Induction+of+multiple+antibiotic+resistance+in+Bacteroides+fragilis+by+benzene+and+benzene-derived+active+compounds+of+commonly+used+analgesics%2C+antiseptics+and+cleaning+agents&rft.au=Pumbwe%2C+Lilian%3BSkilbeck%2C+Christopher+A%3BWexler%2C+Hannah+M&rft.aulast=Pumbwe&rft.aufirst=Lilian&rft.date=2007-12-01&rft.volume=60&rft.issue=6&rft.spage=1288&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ibuprofen; Chlorhexidine; Benzoic acid; Detergents; cinnamaldehyde; Capsaicin; Salicylic acid; Benzene; Phenols; Disinfectants; Cyanide; Antiseptics; Pharmaceuticals; Nodulation; Analgesics; carbonyls; Antibiotic resistance; Acetaminophen; Aromatics; Bacteroides fragilis; Escherichia coli ER - TY - JOUR T1 - Aortic rings stimulate inflammatory angiogenesis in a subcutaneous implant in vivo model AN - 19468735; 8140085 AB - Rat or mouse aortic rings produce angiogenic outgrowths in vitro through endogenous production of growth factors and inflammatory cytokines. To further investigate this process in vivo, collagen-Gelfoam constructs containing aortic rings were implanted subcutaneously in syngeneic animals. Aortic rings stimulated a prominent angiogenic response characterized by peri- and intra-aortic accumulation of florid granulation tissue. Conversely, implants without rings elicited a non-specific inflammatory reaction without significant angiogenesis. The angiogenic response to the rings peaked at day 14 and was followed by regression of neovessels, which were mostly reabsorbed by day 28. Gene expression studies showed upregulated expression of angiogenic growth factors and cytokines in implants with rings. Tracking experiments with LacZ expressing ROSA26 transgenic mice demonstrated that both the aorta and the host contributed to the angiogenic response. These studies show that the angiogenic properties of the rodent aorta can be studied in the live animal under conditions that can be monitored and quantified. This in vivo assay can be used to study the molecular mechanisms by which the arterial wall and its proangiogenic cytokines regulate formation of granulation tissue during wound healing. JF - Angiogenesis AU - Fogel, Eric AU - Aplin, Alfred C AU - Nicosia, Roberto F AD - VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA, 98108, USA, roberto.nicosia@va.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 287 EP - 295 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 10 IS - 4 SN - 0969-6970, 0969-6970 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Aorta KW - Angiogenesis KW - Animal models KW - Wound healing KW - Transgenic mice KW - Inflammation KW - Collagen KW - Models KW - Gene expression KW - Cytokines KW - Growth factors KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19468735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Angiogenesis&rft.atitle=Aortic+rings+stimulate+inflammatory+angiogenesis+in+a+subcutaneous+implant+in+vivo+model&rft.au=Fogel%2C+Eric%3BAplin%2C+Alfred+C%3BNicosia%2C+Roberto+F&rft.aulast=Fogel&rft.aufirst=Eric&rft.date=2007-12-01&rft.volume=10&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Angiogenesis&rft.issn=09696970&rft_id=info:doi/10.1007%2Fs10456-007-9082-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Molecular modelling; Aorta; Animal models; Angiogenesis; Wound healing; Cytokines; Growth factors; Transgenic mice; Models; Collagen; Inflammation DO - http://dx.doi.org/10.1007/s10456-007-9082-0 ER - TY - JOUR T1 - Twenty-four hour plasma cortisol and adrenocorticotropic hormone in Gulf War veterans: relationships to posttraumatic stress disorder and health symptoms. AN - 68475231; 17612507 AB - We aim to characterize the baseline functioning of the hypothalamic-pituitary-adrenal (HPA) axis in Gulf War veterans (GWV) and examine the extent to which posttraumatic stress disorder (PTSD) and unexplained health symptoms-which commonly co-occur-have similar or different biological correlates. Thirty-one GWV, 20 with current PTSD and 11 without current or lifetime PTSD, and 16 healthy nondeployed subjects not exposed to the Gulf War theater underwent medical and psychiatric examination followed by blood sampling every half-hour over 24 hours for the measurement of cortisol and adrenocorticotropic hormone (ACTH). Gulf War veterans without PTSD or another psychiatric disorder had significantly lower 24-hour plasma ACTH levels, a significantly higher cortisol:ACTH ratio, and no difference in cortisol levels compared to nondeployed subjects and to GWV with PTSD, controlling for body mass index (BMI). Among GWV, health symptoms (mood and cognitive symptoms) were positively associated with, and hyperarousal symptoms were negatively associated with, the cortisol:ACTH ratio. Additionally, the self-reported acute effects of pesticides and of pyridostigmine bromide during deployment were associated with lower ACTH levels, controlling for BMI and PTSD. The data provide evidence of HPA axis dysregulation in Gulf War veterans, which may be related to Gulf War deployment exposures. Despite the overlap of chronic unexplained health symptoms and PTSD in GWV, these symptom constellations appear to be biologically distinct. JF - Biological psychiatry AU - Golier, Julia A AU - Schmeidler, James AU - Legge, Juliana AU - Yehuda, Rachel AD - Department of Psychiatry, James J. Peters VA Medical Center, Bronx, New York 10468, USA. Julia.golier@va.gov Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 1175 EP - 1178 VL - 62 IS - 10 SN - 0006-3223, 0006-3223 KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Veterans KW - Analysis of Variance KW - Humans KW - Adult KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - Persian Gulf Syndrome -- blood KW - Stress Disorders, Post-Traumatic -- blood KW - Hydrocortisone -- blood KW - Adrenocorticotropic Hormone -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68475231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Twenty-four+hour+plasma+cortisol+and+adrenocorticotropic+hormone+in+Gulf+War+veterans%3A+relationships+to+posttraumatic+stress+disorder+and+health+symptoms.&rft.au=Golier%2C+Julia+A%3BSchmeidler%2C+James%3BLegge%2C+Juliana%3BYehuda%2C+Rachel&rft.aulast=Golier&rft.aufirst=Julia&rft.date=2007-11-15&rft.volume=62&rft.issue=10&rft.spage=1175&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-01 N1 - Date created - 2007-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A 24-h access I.V. self-administration schedule of morphine reinforcement and the estimation of recidivism: Pharmacological modification by arecoline. AN - 68448453; 17916413 AB - Central cholinergic neurons are known to play a role in the pharmacological actions of opiates. The purpose of the study was to determine whether the muscarinic receptor agonist arecoline, administered during morphine self-administration, would mitigate the subsequent return to self-administration behavior. Rats self-administered increasing concentrations of morphine in operant chambers according to a schedule that permitted unlimited access to lever-activated i.v. infusions on a continuous 24 h basis from 10 to 14 days. Abstinence was induced by discontinuation of the morphine solution and mild withdrawal symptoms were evident from 14 to 74 h. Thereafter the rats remained in their home cages for a 6-week period of protracted abstinence. They were then returned to the operant chambers where lever responding had no reward consequence. The cholinergic muscarinic agonist arecoline was administered twice daily (0.25 or 1 mg/kg, s.c.) throughout the self-administration schedule of morphine. Arecoline treatment partly decreased the self-administration of morphine, it prevented the abstinence-induced decrease in body weight, and it reduced lever responding after protracted withdrawal (by 56%). In animals already dependent on morphine, arecoline failed to alter ongoing self-administration behavior, but responding induced by lever reinstatement 6 weeks after withdrawal was significantly reduced (by 33%). There was a significant relationship between the degree of self-administration activity and the degree of lever responding during reinstatement after protracted abstinence. The results of this study support the role of cholinergic systems in self-administration behavior and context-induced post-withdrawal drug seeking. JF - Neuroscience AU - Buccafusco, J J AU - Bain, J N AD - Veterans Administration Medical Center, Augusta, GA 30904, USA. jbuccafu@mcg.edu Y1 - 2007/11/09/ PY - 2007 DA - 2007 Nov 09 SP - 487 EP - 498 VL - 149 IS - 3 SN - 0306-4522, 0306-4522 KW - Analgesics, Opioid KW - 0 KW - Muscarinic Agonists KW - Muscarinic Antagonists KW - Scopolamine Hydrobromide KW - 451IFR0GXB KW - Arecoline KW - 4ALN5933BH KW - Morphine KW - 76I7G6D29C KW - Index Medicus KW - Rats KW - Animals KW - Self Administration KW - Scopolamine Hydrobromide -- pharmacology KW - Reinforcement Schedule KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Muscarinic Antagonists -- pharmacology KW - Rats, Wistar KW - Substance Withdrawal Syndrome -- drug therapy KW - Substance Withdrawal Syndrome -- psychology KW - Recurrence KW - Male KW - Morphine Dependence -- drug therapy KW - Arecoline -- pharmacology KW - Analgesics, Opioid -- pharmacology KW - Muscarinic Agonists -- pharmacology KW - Morphine Dependence -- psychology KW - Analgesics, Opioid -- administration & dosage KW - Morphine -- administration & dosage KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68448453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=A+24-h+access+I.V.+self-administration+schedule+of+morphine+reinforcement+and+the+estimation+of+recidivism%3A+Pharmacological+modification+by+arecoline.&rft.au=Buccafusco%2C+J+J%3BBain%2C+J+N&rft.aulast=Buccafusco&rft.aufirst=J&rft.date=2007-11-09&rft.volume=149&rft.issue=3&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-16 N1 - Date created - 2007-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Community Collaboration in Implementing the Mental Health Recovery Model T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40778041; 4784067 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Shealy, Suzanne E AU - Brink, Rachel L AU - Gonzales-Nolas, Cheryl AU - Hellickson, Wendy AU - Remick, Lori A AU - Stelley, Jayne E AU - Villavisanis, Robert AU - Wicklund, Kelly M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mental disorders KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40778041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Community+Collaboration+in+Implementing+the+Mental+Health+Recovery+Model&rft.au=Shealy%2C+Suzanne+E%3BBrink%2C+Rachel+L%3BGonzales-Nolas%2C+Cheryl%3BHellickson%2C+Wendy%3BRemick%2C+Lori+A%3BStelley%2C+Jayne+E%3BVillavisanis%2C+Robert%3BWicklund%2C+Kelly+M&rft.aulast=Shealy&rft.aufirst=Suzanne&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of Nursing Home Associated Infections in the Department of Veterans Affairs Nursing Home Care Units T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40776419; 4783774 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Tsan, Linda AU - Davis, Chester AU - Pierce, John R AU - Gaynes, Robert AU - Montgomery, Ona AU - Gibert, Cynthia AU - Hojlo, Christa AU - Bradley, Suzanne AU - Langberg, Robert AU - Danko, Linda AU - Roselle, Gary Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Infection KW - Nursing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40776419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Prevalence+of+Nursing+Home+Associated+Infections+in+the+Department+of+Veterans+Affairs+Nursing+Home+Care+Units&rft.au=Tsan%2C+Linda%3BDavis%2C+Chester%3BPierce%2C+John+R%3BGaynes%2C+Robert%3BMontgomery%2C+Ona%3BGibert%2C+Cynthia%3BHojlo%2C+Christa%3BBradley%2C+Suzanne%3BLangberg%2C+Robert%3BDanko%2C+Linda%3BRoselle%2C+Gary&rft.aulast=Tsan&rft.aufirst=Linda&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mental Health and Substance Abuse among Women Veteran Clinic users with Diabetes T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40768922; 4782632 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Banerjea, Ranjana AU - Pogach, Leonard AU - Sambamoorthi, Usha Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Substance abuse KW - Diabetes mellitus KW - Mental disorders KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Mental+Health+and+Substance+Abuse+among+Women+Veteran+Clinic+users+with+Diabetes&rft.au=Banerjea%2C+Ranjana%3BPogach%2C+Leonard%3BSambamoorthi%2C+Usha&rft.aulast=Banerjea&rft.aufirst=Ranjana&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disproportionately High Rates of STDs among Men Who have Sex with Men (MSM) T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766894; 4783489 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Valdiserri, Ronald Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Sexually-transmitted diseases KW - Homosexuality KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Disproportionately+High+Rates+of+STDs+among+Men+Who+have+Sex+with+Men+%28MSM%29&rft.au=Valdiserri%2C+Ronald&rft.aulast=Valdiserri&rft.aufirst=Ronald&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Iraq on a Soldier and his Family T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766328; 4782473 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Sanchez, Aundrey J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Iraq KW - Soldiers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Impact+of+Iraq+on+a+Soldier+and+his+Family&rft.au=Sanchez%2C+Aundrey+J&rft.aulast=Sanchez&rft.aufirst=Aundrey&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association between Alcohol Use and Unintentional Injuries Post-Spinal Cord Injury (SCI) T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766033; 4783203 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - LaVela, Sherri L AU - Smith, Bridget Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Injuries KW - Alcohols KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Association+between+Alcohol+Use+and+Unintentional+Injuries+Post-Spinal+Cord+Injury+%28SCI%29&rft.au=LaVela%2C+Sherri+L%3BSmith%2C+Bridget&rft.aulast=LaVela&rft.aufirst=Sherri&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparing Three Datasets on Payers for the Private Sector Inpatient Care of VA Patients T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763885; 4783379 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - West, Alan AU - Weeks, William B Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Private sector KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Comparing+Three+Datasets+on+Payers+for+the+Private+Sector+Inpatient+Care+of+VA+Patients&rft.au=West%2C+Alan%3BWeeks%2C+William+B&rft.aulast=West&rft.aufirst=Alan&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nurses on the Frontline at the VAMC: Involved in Developing and Designing New Health Information Systems T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762786; 4783412 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Boucher, Michael J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Nursing KW - Information systems KW - Medical personnel KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Nurses+on+the+Frontline+at+the+VAMC%3A+Involved+in+Developing+and+Designing+New+Health+Information+Systems&rft.au=Boucher%2C+Michael+J&rft.aulast=Boucher&rft.aufirst=Michael&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association between Interpersonal Violence and Self-Reported Chlamydia Diagnosis among California Women T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762719; 4783462 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Pavao, Joanne AU - Alvarez, Jennifer AU - Chow, Joan AU - Baumrind, Nikki AU - Kimerling, Rachel Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA, California KW - Violence KW - Aggression KW - Chlamydia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Association+between+Interpersonal+Violence+and+Self-Reported+Chlamydia+Diagnosis+among+California+Women&rft.au=Pavao%2C+Joanne%3BAlvarez%2C+Jennifer%3BChow%2C+Joan%3BBaumrind%2C+Nikki%3BKimerling%2C+Rachel&rft.aulast=Pavao&rft.aufirst=Joanne&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What' s Wrong with Torture? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762471; 4783529 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Shuster, Evelyne Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Politics KW - Public health KW - Ethics KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=What%27+s+Wrong+with+Torture%3F&rft.au=Shuster%2C+Evelyne&rft.aulast=Shuster&rft.aufirst=Evelyne&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Challenges and Recommendations for Avoiding Bias While Testing Behavioral Interventions for Chronic Medical Conditions T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40760993; 4781112 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Friedberg, Jennifer P AU - Robinaugh, Donald AU - Branson, Yvette AU - Ulmer, Michelle AU - Natarajan, Sundar Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Challenges+and+Recommendations+for+Avoiding+Bias+While+Testing+Behavioral+Interventions+for+Chronic+Medical+Conditions&rft.au=Friedberg%2C+Jennifer+P%3BRobinaugh%2C+Donald%3BBranson%2C+Yvette%3BUlmer%2C+Michelle%3BNatarajan%2C+Sundar&rft.aulast=Friedberg&rft.aufirst=Jennifer&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Risk Factors for Lower Extremity Ulcer in the Morbidly Obese Diabetic Patients T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40760916; 4781008 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Budiman-Mak, Elly AU - Sohn, Min-Woong AU - Stuck, Rodney Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Obesity KW - Extremities KW - Ulcers KW - Diabetes mellitus KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Risk+Factors+for+Lower+Extremity+Ulcer+in+the+Morbidly+Obese+Diabetic+Patients&rft.au=Budiman-Mak%2C+Elly%3BSohn%2C+Min-Woong%3BStuck%2C+Rodney&rft.aulast=Budiman-Mak&rft.aufirst=Elly&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Retrospective Analysis of Geospatial and Demographic Risk Factors for Human West Nile Virus (WNV) Infection in the Texas Panhandle, 2003 T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40755780; 4780716 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Denison, Anne V AU - Pierce Jr, J Rush Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA, Texas KW - Infection KW - Demography KW - Risk factors KW - West Nile virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40755780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Retrospective+Analysis+of+Geospatial+and+Demographic+Risk+Factors+for+Human+West+Nile+Virus+%28WNV%29+Infection+in+the+Texas+Panhandle%2C+2003&rft.au=Denison%2C+Anne+V%3BPierce+Jr%2C+J+Rush&rft.aulast=Denison&rft.aufirst=Anne&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nurse Practitioners' and Physicians Views of NPs as Providers of Primary Care to Veterans T2 - 39th Biennial Convention of the Honor Society of Nursing AN - 40742907; 4773729 JF - 39th Biennial Convention of the Honor Society of Nursing AU - Fletcher, Carol E AU - Baker, S Jill AU - Reeves, Pamela J AU - Lowery, Julie C Y1 - 2007/11/02/ PY - 2007 DA - 2007 Nov 02 KW - Nursing KW - Medical personnel KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40742907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Biennial+Convention+of+the+Honor+Society+of+Nursing&rft.atitle=Nurse+Practitioners%27+and+Physicians+Views+of+NPs+as+Providers+of+Primary+Care+to+Veterans&rft.au=Fletcher%2C+Carol+E%3BBaker%2C+S+Jill%3BReeves%2C+Pamela+J%3BLowery%2C+Julie+C&rft.aulast=Fletcher&rft.aufirst=Carol&rft.date=2007-11-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Biennial+Convention+of+the+Honor+Society+of+Nursing&rft.issn=&rft_id=info:doi/ L2 - http://stti.confex.com/stti/bc39/techprogram/meeting_bc39.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Intra- and inter-session test, retest reliability of the Words-in-Noise (WIN) test. AN - 85404389; pmid-18496992 AB - Retest stability and retest reliability were assessed for the Words-in-Noise Test (WIN) in two experiments involving older listeners with sensorineural hearing loss. In Experiment 1, the 70-item WIN protocol was administered during two sessions 12 months apart to examine retest stability on a sample of 315 veterans from four VA Medical Centers. The mean 50% points on the WIN were 12.5- and 12.8-dB S/N for the two sessions with a critical difference of 3.5 dB and an intra-class correlation coefficient of 0.88. [Normal recognition performance on the WIN (50% point) is < or =6-dB S/N.] In Experiment 2, intra- and inter-session retest reliability was examined for the two 35-word WIN protocols on 96 veterans, 48 of whom had mild-to-severe hearing loss (Group 1) and 48 of whom had a moderate-to-severe hearing loss (Group 2). The mean 50% points on the WIN during the two sessions (separated by 40 days) were 13.0- and 13.4-dB S/N (Group 1) and 15.3- and 15.8-dB S/N (Group 2) with no significant intra-session differences. A 3.1-dB critical difference was calculated for the groups combined with intra-class correlations of 0.89 and 0.91 for Group 1 and Group 2, respectively. JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AU - McArdle, Rachel AD - James H. Quillen VA Medical Center, Mountain Home, Tennessee 37684, USA. RICHARD.WILSON2@VA.GOV Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 813 EP - 825 VL - 18 IS - 10 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Audiometry, Pure-Tone KW - Female KW - *Hearing Loss, Sensorineural: diagnosis KW - Hearing Loss, Sensorineural: physiopathology KW - Humans KW - Male KW - Noise KW - Reproducibility of Results KW - *Speech Discrimination Tests: methods KW - Speech Perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85404389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Intra-+and+inter-session+test%2C+retest+reliability+of+the+Words-in-Noise+%28WIN%29+test.&rft.au=Wilson%2C+Richard+H%3BMcArdle%2C+Rachel&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2007-11-01&rft.volume=18&rft.issue=10&rft.spage=813&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The ability to listen with independent ears. AN - 742782821; pmid-18189571 AB - In three experiments, listeners identified speech processed into narrow bands and presented to the right ("target") ear. The ability of listeners to ignore (or even use) conflicting contralateral stimulation was examined by presenting various maskers to the target ear ("ipsilateral") and nontarget ear ("contralateral"). Theoretically, an absence of contralateral interference would imply selectively attending to only the target ear; the presence of interference from the contralateral stimulus would imply that listeners were unable to treat the stimuli at the two ears independently; and improved performance in the presence of informative contralateral stimulation would imply that listeners can process the signals at both ears and keep them separate rather than combining them. Experiments showed evidence of the ability to selectively process (or respond to) only the target ear in some, but not all, conditions. No evidence was found for improved performance due to contralateral stimulation. The pattern of interference found across experiments supports an interaction of stimulus-based factors (auditory grouping) and task-based factors (demand for processing resources) and suggests that listeners may not always be able to listen to the "better" ear even when it would be beneficial to do so. JF - The Journal of the Acoustical Society of America AU - Gallun, Frederick J AU - Mason, Christine R AU - Kidd, Gerald AD - Department of Speech, Language and Hearing Sciences, and Hearing Research Center, Boston University, 635 Commonwealth Avenue, Boston, Massachusetts 02215, USA. Frederick.Gallun@va.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2814 EP - 2825 VL - 122 IS - 5 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Analysis of Variance KW - Humans KW - Adult KW - Noise KW - Acoustic Stimulation -- methods KW - Attention KW - Perceptual Masking KW - Speech KW - Female KW - Male KW - Hearing -- physiology KW - Ear -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742782821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=The+ability+to+listen+with+independent+ears.&rft.au=Gallun%2C+Frederick+J%3BMason%2C+Christine+R%3BKidd%2C+Gerald&rft.aulast=Gallun&rft.aufirst=Frederick&rft.date=2007-11-01&rft.volume=122&rft.issue=5&rft.spage=2814&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Metoclopramide does not influence the frequency of propofol-induced spontaneous movements. AN - 69044340; 18063208 AB - To evaluate the effects of metoclopramide on the frequency and severity of propofol-induced movements. Randomized, double blind, placebo-controlled trial. Veterans Administration Medical Center. One hundred thirty-seven consenting adults scheduled to receive general anesthesia with propofol induction. Patients were randomized to receive either metoclopramide 10 mg intravenously (IV) or placebo (saline) 3 min before induction of general anesthesia. All patients received midazolam 1 to 2 mg IV, fentanyl 50 to 150 microg IV, and lidocaine 50 to 80 mg IV before induction of anesthesia. Occurrence of spontaneous movements and severity during the observation period were recorded after propofol induction by observing movement in the hands/arms and feet/legs, as well as presence of a hiccup. The dosage of anesthetic medications administered was also recorded for each patient. No differences were noted in the frequency and severity of spontaneous movement in the patients who had received metoclopramide and placebo. However, compared with the patients who did not move, patients who experienced movements received a significantly higher dose of propofol (P = 0.025) and a lower dose of fentanyl (P = 0.049). Metoclopramide does not affect the frequency of propofol-induced movements, but propofol and fentanyl doses influence the frequency of movements during propofol induction. JF - Journal of clinical anesthesia AU - Lenkovsky, Fima AU - Robertson, Brian D AU - Iyer, Chandramouli AU - Ross, Larry AU - Ahmed, Syed A AU - Herazo, Luis AU - Markin, Vladislav AU - Joshi, Girish P AD - Department of Anesthesiology and Pain Management Service, Dallas Veterans Affairs Medical Center, Dallas, TX 75216, USA. fima.lenkovsky@va.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 530 EP - 533 VL - 19 IS - 7 SN - 0952-8180, 0952-8180 KW - Anesthetics, Intravenous KW - 0 KW - Antiemetics KW - Hypnotics and Sedatives KW - Metoclopramide KW - L4YEB44I46 KW - Midazolam KW - R60L0SM5BC KW - Fentanyl KW - UF599785JZ KW - Propofol KW - YI7VU623SF KW - Index Medicus KW - Hiccup -- epidemiology KW - Drug Interactions KW - Hiccup -- chemically induced KW - Double-Blind Method KW - Humans KW - Anesthesia, General KW - Aged KW - Middle Aged KW - Sample Size KW - Male KW - Female KW - Myoclonus -- chemically induced KW - Antiemetics -- therapeutic use KW - Myoclonus -- prevention & control KW - Anesthetics, Intravenous -- adverse effects KW - Propofol -- adverse effects KW - Antiemetics -- adverse effects KW - Metoclopramide -- therapeutic use KW - Metoclopramide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69044340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+anesthesia&rft.atitle=Metoclopramide+does+not+influence+the+frequency+of+propofol-induced+spontaneous+movements.&rft.au=Lenkovsky%2C+Fima%3BRobertson%2C+Brian+D%3BIyer%2C+Chandramouli%3BRoss%2C+Larry%3BAhmed%2C+Syed+A%3BHerazo%2C+Luis%3BMarkin%2C+Vladislav%3BJoshi%2C+Girish+P&rft.aulast=Lenkovsky&rft.aufirst=Fima&rft.date=2007-11-01&rft.volume=19&rft.issue=7&rft.spage=530&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+anesthesia&rft.issn=09528180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-24 N1 - Date created - 2007-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effect of integrated medical-substance abuse treatment during an acute illness on subsequent health services utilization. AN - 69009077; 18049353 AB - The acute care hospital provides a context for engaging difficult to reach patients in substance abuse treatment (SAT); however, little is known regarding the effects of such engagement on subsequent health services utilization. We examined whether a structured day hospital (DH) intervention integrating SAT and medical care during an acute medical hospitalization would reduce subsequent emergency department (ED) use and rehospitalization compared with a control group receiving usual medical care and referral to intensive outpatient SAT. Between October 2001 and June 2002, we enrolled 390 hospitalized substance using patients in a nonrandomized clinical trial. Once stabilized, patients were assigned to either the DH intervention (n = 63) or usual care control group (n = 327). Baseline interview and chart review collected data on demographics, substance use, and acute and chronic medical conditions. Subsequent chart review collected data on ED, hospital and ambulatory care utilization in the 6 months pre-enrollment and 6 months postdischarge. Univariate and multiple logistic regression methods were used to assess the independent effects of the DH intervention on postdischarge health care utilization. Overall 25%, 48%, and 42% reported > or =3 ED episodes, > or =1 rehospitalization, and > or =1 ambulatory care visit during the postdischarge period. Subjects who completed the DH intervention were significantly less likely to have > or =3 ED episodes (AOR = 0.27; 95% CI, 0.08-0.89) and more likely to have > or =1 ambulatory care visit (AOR = 4.05; 95% CI, 1.44-11.37) than the usual care group. No similarly beneficial effects were seen for patients who initiated but did not complete the DH intervention. : A DH model that engages acutely ill substance using patients in integrated medical and substance abuse treatment can positively influence subsequent health care seeking behavior. JF - Medical care AU - O'Toole, Thomas P AU - Pollini, Robin A AU - Ford, Daniel E AU - Bigelow, George AD - Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. thomas.o'toole@va.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1110 EP - 1115 VL - 45 IS - 11 SN - 0025-7079, 0025-7079 KW - Index Medicus KW - Patient Readmission -- statistics & numerical data KW - Acute Disease KW - Humans KW - Adult KW - Middle Aged KW - Emergency Service, Hospital -- utilization KW - Chronic Disease KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Health Services -- utilization KW - Substance-Related Disorders -- ethnology KW - Hospital Administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69009077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=The+effect+of+integrated+medical-substance+abuse+treatment+during+an+acute+illness+on+subsequent+health+services+utilization.&rft.au=O%27Toole%2C+Thomas+P%3BPollini%2C+Robin+A%3BFord%2C+Daniel+E%3BBigelow%2C+George&rft.aulast=O%27Toole&rft.aufirst=Thomas&rft.date=2007-11-01&rft.volume=45&rft.issue=11&rft.spage=1110&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-19 N1 - Date created - 2007-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Homocysteine, vitamins, and vascular disease prevention. AN - 68492917; 17991676 AB - In mid-20th century United States, deaths from vascular disease reached a peak incidence in 1955, but little was known about the underlying causes of this epidemic of disease. The significance of homocysteine in human disease was unknown until 1962, when cases of homocystinuria were first associated with vascular disease. Analysis of an archival case of homocystinuria from 1933 and a case of cobalamin C disease from 1968 led to the conclusion that homocysteine causes vascular disease by a direct effect of the amino acid on arterial cells and tissues. The homocysteine theory of arteriosclerosis attributes one of the underlying causes of vascular disease to elevation of blood homocysteine concentrations as the result of dietary, genetic, metabolic, hormonal, or toxic factors. Dietary deficiency of vitamin B-6 and folic acid and absorptive deficiency of vitamin B-12, which result from traditional food processing or abnormal absorption of B vitamins, are important factors in causing elevations in blood homocysteine. Numerous clinical and epidemiologic studies have established elevated blood homocysteine as a potent independent risk factor for vascular disease in the general population. Dietary improvement, providing abundant vitamin B-6, folic acid, and cobalamin, may prevent vascular disease by lowering blood homocysteine. The dramatic decline in cardiovascular mortality in the United States since 1950 may possibly be attributable in part to voluntary fortification of the food supply with vitamin B-6 and folic acid. Fortification of the US food supply with folic acid in 1998, as mandated by the US Food and Drug Administration, was associated with a further decline in mortality from vascular disease, presumably because of increased blood folate and decreased blood homocysteine in the population. JF - The American journal of clinical nutrition AU - McCully, Kilmer S AD - Pathology and Laboratory Medicine Service, Department of Veterans Affairs Medical Center, West Roxbury, MA, USA. kilmer.mccully@med.va.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1563S EP - 8S VL - 86 IS - 5 SN - 0002-9165, 0002-9165 KW - Homocysteine KW - 0LVT1QZ0BA KW - Vitamin B 6 KW - 8059-24-3 KW - Folic Acid KW - 935E97BOY8 KW - Vitamin B 12 KW - P6YC3EG204 KW - Abridged Index Medicus KW - Index Medicus KW - Atherosclerosis -- etiology KW - Humans KW - Aged KW - Dietary Supplements KW - Folic Acid -- administration & dosage KW - Homocysteine -- blood KW - Vitamin B 6 -- administration & dosage KW - Vascular Diseases -- prevention & control KW - Vitamin B 12 -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68492917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Homocysteine%2C+vitamins%2C+and+vascular+disease+prevention.&rft.au=McCully%2C+Kilmer+S&rft.aulast=McCully&rft.aufirst=Kilmer&rft.date=2007-11-01&rft.volume=86&rft.issue=5&rft.spage=1563S&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Clin Nutr. 2008 Apr;87(4):1069-70; author reply 1070-1 [18400736] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical consequences of polypharmacy in elderly: expect the unexpected, think the unthinkable. AN - 68450223; 17967158 AB - Multiple medication use has been coined 'polypharmacy'. Polypharmacy is highly prevalent in older patients secondary to the increased number of co-morbid disease states with ageing. Existing practice guidelines recommend multiple drug use for certain chronic diseases (i.e., HIV, tuberculosis, hypertension, etc.). A polypharmacologic approach for certain diseases has been shown to improve therapeutic response, decrease morbidity and mortality. On the contrary, polypharmacy may induce iatrogenic complications that are often unseen prior to the initiation of medicinal regimens. This paper will review the potential clinical consequences of polypharmacy in the elderly and common medication administration errors that may occur. Consequences of polypharmacy include adverse drug effects, drug-drug interactions, disease-drug interactions, food-drug interactions, nutraceutical-drug interactions and medication cascade effect. Medication administration errors, such as phonetic confusion, flip-flopping dosing errors and pill visual-cue errors, are also reviewed. Prescribing for the elderly, whose medications are vast in number, is often uncharted physiologic territory. The clinician must expect the unexpected and think of the unthinkable in the geriatric patient, when dealing with polypharmacy and the potential consequences. JF - Expert opinion on drug safety AU - Salazar, Joel A AU - Poon, Ivy AU - Nair, Mridula AD - Transitional Care Center, Michael E DeBakey VA Medical Center, Baylor College of Medicine, 2002 Holcombe Blvd, Houston, TX 77030, USA. joel.Salazar@VA.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 695 EP - 704 VL - 6 IS - 6 KW - Index Medicus KW - Animals KW - Medication Errors -- adverse effects KW - Humans KW - Food-Drug Interactions -- physiology KW - Aged KW - Polypharmacy KW - Drug Interactions -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68450223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+safety&rft.atitle=Clinical+consequences+of+polypharmacy+in+elderly%3A+expect+the+unexpected%2C+think+the+unthinkable.&rft.au=Salazar%2C+Joel+A%3BPoon%2C+Ivy%3BNair%2C+Mridula&rft.aulast=Salazar&rft.aufirst=Joel&rft.date=2007-11-01&rft.volume=6&rft.issue=6&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+safety&rft.issn=1744-764X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Involvement of alpha(2)-adrenoceptors in the gastric protective effect of nitroglycerin against acidified ethanol-induced mucosal injury. AN - 68334919; 17394070 AB - Clinical observations reveal that alcohol intake is associated with an increase in upper gastrointestinal hemorrhage requiring hospitalization and that nitroglycerin or long-acting nitrates lower this risk. Nitroglycerin, a gastric vasodilator that can increase gastric fluid volume, protects the rodent stomach against damage, including that caused by 70% ethanol. Blockade of alpha(2)-adrenoceoptors attenuates gastric protection by intragastric nicotine against 40% ethanol. We tested the hypothesis that the protective effect of nitroglycerin is mediated by an increase in gastric fluid volume and alpha(2)-adrenoceoptors. Nitroglycerin, 5 mg/kg, vehicle, or acidified ethanol was administered intragastrically. In study 1 acidified ethanol-induced mucosal injury was measured. In study 2 the effect of increasing gastric volume (1 ml/kg) on mucosal injury was assessed. In study 3 the effect of yohimbine (alpha(2)-adrenoceoptor antagonist), 5 mg/kg subcutaneously, on the nitroglycerein-mediated protective effect was determined. Results showed that nitroglycerin significantly attenuated the number and length of mucosal lesions induced by acidified ethanol. Increase in gastric fluid volume by exogenously administered saline did not alter the protective effect. Yohimbine blocked the nitroglycerin-mediated protection. These experimental data are consistent with the observation that nitrates lower the risk of ethanol-induced gastrointestinal complications. alpha(2)-Adrenoceoptors are responsible in part for the protective effect of nitroglycerin. JF - Digestive diseases and sciences AU - Leung, Felix W AU - Chan, Chi Chung AD - 111G, Division of Gastroenterology, Sepulveda Ambulatory Care Center, 16111 Plummer Street, Sepulveda, CA 91343, USA. felix.leung@va.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 3070 EP - 3074 VL - 52 IS - 11 SN - 0163-2116, 0163-2116 KW - Central Nervous System Depressants KW - 0 KW - Nicotinic Agonists KW - Receptors, Adrenergic, alpha-2 KW - Vasodilator Agents KW - Ethanol KW - 3K9958V90M KW - Nicotine KW - 6M3C89ZY6R KW - Nitroglycerin KW - G59M7S0WS3 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Central Nervous System Depressants -- toxicity KW - Nicotine -- pharmacology KW - Ethanol -- toxicity KW - Disease Models, Animal KW - Mice KW - Nicotinic Agonists -- pharmacology KW - Male KW - Female KW - Organ Size -- drug effects KW - Stomach Diseases -- metabolism KW - Stomach Diseases -- chemically induced KW - Receptors, Adrenergic, alpha-2 -- drug effects KW - Receptors, Adrenergic, alpha-2 -- metabolism KW - Vasodilator Agents -- therapeutic use KW - Gastric Mucosa -- drug effects KW - Nitroglycerin -- therapeutic use KW - Stomach Diseases -- prevention & control KW - Gastric Mucosa -- pathology KW - Gastric Mucosa -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68334919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Involvement+of+alpha%282%29-adrenoceptors+in+the+gastric+protective+effect+of+nitroglycerin+against+acidified+ethanol-induced+mucosal+injury.&rft.au=Leung%2C+Felix+W%3BChan%2C+Chi+Chung&rft.aulast=Leung&rft.aufirst=Felix&rft.date=2007-11-01&rft.volume=52&rft.issue=11&rft.spage=3070&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-13 N1 - Date created - 2007-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Do Men and Women Differ on Measures of Mental Stress-Induced Ischemia? AN - 57339744; 200815697 AB - Objective: To consider the effects of gender on ischemia in a larger sample, with broadly defined coronary artery disease (CAD). Mental stress has been shown to cause transient myocardial ischemia in a significant percentage of people with CAD. However, little is known about the effects of mental stress on ischemic processes in women. Most studies to date either had few women or required a positive exercise stress test. Methods: Participants (61 women, 93 men; average age = 63 years) had documented CAD (positive stress test, abnormal catheterization even with minimal disease, or previous myocardial infarction). They underwent mental stress testing and radionuclide perfusion imaging (stress/ rest). Cardiac function data were collected and stress was compared with baseline. The data were then submitted to a series of analyses of variance. Results: A total of 50 (32%) participants exhibited reversible ischemia post psychological stress. This reflects a relative rate of 33% (n = 31 of 93) for men and 31 %(n = 19 of 61) for women. No difference between men and women were observed on any measure of hemodynamic functioning (blood pressure, heart rate, or cardiac perfusion). Conclusions: Results of this study showed no significant differences between men and women on measures of hemodynamic functioning or cardiac perfusion. Adapted from the source document. JF - Psychosomatic Medicine AU - York, Kaki M AU - Hassan, Mustafa AU - Li, Qin AU - Li, Haihong AU - Fillingim, Roger B AU - Lucey, Dorian AU - Bestland, Melinda AU - Sheps, David S AD - Psychology Service (116B), 1601 SW Archer Rd, Gainesville, FL 32608 kaki.york@va.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 918 EP - 922 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 69 IS - 9 SN - 0033-3174, 0033-3174 KW - gender, mental stress, myocardial ischemia, hemodynamic, single photon emission computed tomography KW - Heart rate KW - Stress KW - Gender differences KW - Myocardial infarction KW - Single photon emission computed tomography KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57339744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+Medicine&rft.atitle=Do+Men+and+Women+Differ+on+Measures+of+Mental+Stress-Induced+Ischemia%3F&rft.au=York%2C+Kaki+M%3BHassan%2C+Mustafa%3BLi%2C+Qin%3BLi%2C+Haihong%3BFillingim%2C+Roger+B%3BLucey%2C+Dorian%3BBestland%2C+Melinda%3BSheps%2C+David+S&rft.aulast=York&rft.aufirst=Kaki&rft.date=2007-11-01&rft.volume=69&rft.issue=9&rft.spage=918&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+Medicine&rft.issn=00333174&rft_id=info:doi/10.1097%2FPSY.0b013e31815a9245 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-02-03 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMEAP N1 - SubjectsTermNotLitGenreText - Stress; Gender differences; Heart rate; Myocardial infarction; Single photon emission computed tomography DO - http://dx.doi.org/10.1097/PSY.0b013e31815a9245 ER - TY - JOUR T1 - Prediction of Police Officer Performance Among New Mexico State Police as Assessed by the Personality Assessment Inventory AN - 57286627; 200912888 AB - Little research has been conducted regarding the use of the Personality Assessment Inventory (PAI) in law enforcement screening and selection. The limited body of research that does exist appears to support its utility in the selection process. The purpose of the present study was to investigate the validity and reliability of the Psychological Rating Risk Factor Statement (PRRFS) developed by Roberts, Thompson, and Johnson (2004) in predicting and discriminating problem from non-problem New Mexico State Police (NMSP) applicants. PAI profiles for each officer were obtained and transferred into the PAI Law Enforcement, Corrections, and Public Safety Selection software program, which generated probability estimates (PRRFS) to predict the likelihood that participants were not well-suited for a career in law enforcement. Subsequent logistic regression and receiver operating characteristic (ROC) statistical analyses revealed that the PRRFS was ineffective in predicting and discriminating between problem and non-problem officers. Potential explanations for this finding are discussed. Adapted from the source document. JF - Journal of Police and Criminal Psychology AU - Richardson, David W AU - Cave, Susan B AU - La Grange, Linda AD - Department of Veteran Affairs, Tennessee Valley Healthcare System, Murfreesboro, TN, USA david.richardson3@va.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 84 EP - 90 PB - Springer Science+Business Media, Inc, New York, NY VL - 22 IS - 2 SN - 0882-0783, 0882-0783 KW - Police officers KW - Job performance KW - Personality KW - Applicants KW - Personality tests KW - At risk KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57286627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Police+and+Criminal+Psychology&rft.atitle=Prediction+of+Police+Officer+Performance+Among+New+Mexico+State+Police+as+Assessed+by+the+Personality+Assessment+Inventory&rft.au=Richardson%2C+David+W%3BCave%2C+Susan+B%3BLa+Grange%2C+Linda&rft.aulast=Richardson&rft.aufirst=David&rft.date=2007-11-01&rft.volume=22&rft.issue=2&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Journal+of+Police+and+Criminal+Psychology&rft.issn=08820783&rft_id=info:doi/10.1007%2Fs11896-007-9010-7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Personality tests; Police officers; Personality; At risk; Job performance; Applicants DO - http://dx.doi.org/10.1007/s11896-007-9010-7 ER - TY - JOUR T1 - Combat veterans show normal discrimination during differential trace eyeblink conditioning, but increased responsivity to the conditioned and unconditioned stimulus AN - 57231388; 200716624 AB - The question addressed in the present study was whether post-traumatic stress disorder (PTSD) results in associative learning impairments. To answer this question, differential trace eyeblink (EB) conditioning was studied in combat veterans with PTSD, combat veterans without PTSD, and non-combat veterans without PTSD. Veterans with PTSD showed normal EB discrimination, suggesting that associative learning is not impaired by PTSD. Veterans with PTSD also showed normal extinction. However, subjects with PTSD showed more EB conditioned responses (CRs), as well as increased CR amplitude. Increased response amplitude to the airpuff unconditioned stimulus presented alone (viz. the unconditioned response), as well as to the airpuff on CS+ trials during conditioning also occurred in the subjects with PTSD. These findings suggest increased reactivity in combat veterans with PTSD, compared to those without PTSD, but such heightened reactivity does not affect somatomotor associative learning. [Copyright 2006 Elsevier Ltd.] JF - Journal of Psychiatric Research AU - Burriss, Louisa AU - Ayers, Edwin AU - Powell, D A AD - Shirley L. Buchanan Neuroscience Laboratory (151A), Wm. Jennings Bryan Dorn VA Medical Center, Columbia, SC 29209, United States email: donnie.powell@med.va.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 785 EP - 794 PB - Elsevier Ltd, Oxford UK VL - 41 IS - 9 SN - 0022-3956, 0022-3956 KW - Associative learning KW - Discrimination KW - Extinction KW - Somatomotor conditioning KW - Anxiety KW - Medication KW - Veterans KW - Combat related posttraumatic stress disorder KW - Eye movements KW - Learning disabilities KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57231388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychiatric+Research&rft.atitle=Combat+veterans+show+normal+discrimination+during+differential+trace+eyeblink+conditioning%2C+but+increased+responsivity+to+the+conditioned+and+unconditioned+stimulus&rft.au=Burriss%2C+Louisa%3BAyers%2C+Edwin%3BPowell%2C+D+A&rft.aulast=Burriss&rft.aufirst=Louisa&rft.date=2007-11-01&rft.volume=41&rft.issue=9&rft.spage=785&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychiatric+Research&rft.issn=00223956&rft_id=info:doi/10.1016%2Fj.jpsychires.2006.04.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-09-28 N1 - Last updated - 2016-09-27 N1 - CODEN - JPYRA3 N1 - SubjectsTermNotLitGenreText - Eye movements; Combat related posttraumatic stress disorder; Associative learning; Veterans; Learning disabilities DO - http://dx.doi.org/10.1016/j.jpsychires.2006.04.004 ER - TY - JOUR T1 - Fluoroquinolone Use and Risk Factors for Clostridium difficile-Associated Disease within a Veterans Administration Health Care System AN - 20847456; 8231580 AB - Background. Prompted by the changing profile of Clostridium difficile infection and the impact of formulary policies in hospitals, we performed this study when an increase in the incidence of C. difficile-associated disease was noted at our health care center (Veterans Administration Puget Sound Health Care System, Seattle, Washington). Methods. A retrospective, matched case-control study of patients presenting to the Veterans Administration Puget Sound Health Care System, Seattle, Washington during 2004 was performed. Conditional logistic analysis determined risk factors for case patients, defined as individuals with diarrhea and test results (i.e., culture or toxin assay results) positive for C. difficile, and control subjects, defined as individuals with diarrhea and test results negative for C. difficile. Results. C. difficile-associated disease incidence was 29.2 cases per 10,000 inpatient-days. The increase in the incidence of C. difficile-associated diarrhea that paralleled increased gatifloxacin use was not attributable to use of the antimicrobial but was a reflection of seasonal variation in the rate of C. difficile-associated disease. Multivariate analysis controlling for the time at which the assay was performed, the age of the patient, ward, and source of acquisition (community-acquired vs. nosocomial disease) found 6 significant risk factors for C. difficile-associated diarrhea: receipt of clindamycin (adjusted odds ratio [aOR], 29.9; 95% confidence interval [CI], 3.58-249.4), receipt of penicillin (aOR, 4.1; 95% CI, 1.2-13.9), having a lower intestinal condition (aOR, 2.8; 95% CI, 1.3-6.1), total number of antibiotics received (aOR, 1.4; 95% CI, 1.1-1.7), number of prior hospital admissions (aOR, 1.3; 95% CI, 1.1-1.6), and number of comorbid conditions (aOR, 1.3; 95% CI, 1.1-1.5). Conclusions. The increase in the number of cases of C. difficile-associated disease was not attributable to a formulary change of fluoroquinolones; instead, the incidence was within expected seasonal variations for C. difficile-associated disease. Recognition of community-acquired cases and the use of culture may help to identify additional cases of C. difficile-associated disease. Early diagnosis and treatment of C. difficile cases may shorten the duration of hospital stays and reduce the number of outbreaks and readmissions, mortality, and other consequences of C. difficile infection. JF - Clinical Infectious Diseases AU - McFarland, LV AU - Clarridge, JE AU - Beneda, H W AU - Raugi, G J AD - Dept. of Health Services Research and Development, VA Puget Sound Health Care System, S152, 1100 Olive Way #1400, Seattle, WA 98101, USA, Lynne.McFarland@va.gov Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 1141 EP - 1151 VL - 45 IS - 9 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - Clostridium KW - Mortality KW - Clindamycin KW - Age KW - Diarrhea KW - Fluoroquinolones KW - Antibiotics KW - Infection KW - Toxins KW - Penicillin KW - Gatifloxacin KW - Multivariate analysis KW - Risk factors KW - Intestine KW - Sound KW - Clostridium difficile KW - Seasonal variations KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20847456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Fluoroquinolone+Use+and+Risk+Factors+for+Clostridium+difficile-Associated+Disease+within+a+Veterans+Administration+Health+Care+System&rft.au=McFarland%2C+LV%3BClarridge%2C+JE%3BBeneda%2C+H+W%3BRaugi%2C+G+J&rft.aulast=McFarland&rft.aufirst=LV&rft.date=2007-11-01&rft.volume=45&rft.issue=9&rft.spage=1141&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Clindamycin; Diarrhea; Fluoroquinolones; Antibiotics; Infection; Penicillin; Toxins; Gatifloxacin; Multivariate analysis; Risk factors; Sound; Intestine; Seasonal variations; Hospitals; Clostridium; Clostridium difficile ER - TY - JOUR T1 - Mouse chromosome 9 quantitative trait loci for soft tissue regeneration: Congenic analysis and fine mapping AN - 20810666; 8009405 AB - Development of gene therapies for wound healing will depend on the identification of the genes involved in wound healing and tissue regeneration. Previous quantitative trait loci (QTL) studies in mice using the ear punch model have shown that major QTL exist on chromosome (Chr) 9 for soft tissue regeneration. In this study, we have developed a congenic line that contains the Chr 9 QTL chromosomal region from super healer MRL-MpJ in the genomic background of poor-healing SJL-J. The phenotypic effect of this QTL was confirmed in male mice, where the congenic line has shown significant healing improvement over SJL. Fine mapping of the Chr 9 QTL region with 23 markers at an average distance of 4.2 Mb using a total of 1,564 MRL-MpJ x SJL-J F sub(2) mice revealed the presence of at least three QTL peaks, implying that three separate loci may contribute to the phenotypic effect of this QTL. Based on the 2-LOD intervals, the total QTL region was confined to a combined length of no more than 28.2 Mb. Application of a Bayesian shrinkage estimation indicated that a major locus was located in a region of just 1.3 Mb. JF - Wound Repair and Regeneration AU - Yu, Hongrun AU - Baylink, David J AU - Masinde, Godfred L AU - Li, Runzhi AU - Nguyen, Bay AU - Davidson, Heather M AU - Xu, Shizhong AU - Mohan, Subburaman AD - Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, California, Subburaman.Mohan@va.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 922 EP - 927 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 15 IS - 6 SN - 1067-1927, 1067-1927 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - chromosome 9 KW - Quantitative trait loci KW - Mathematical models KW - Gene therapy KW - Bayesian analysis KW - Wound healing KW - Ear KW - Atrophy KW - genomics KW - Soft tissues KW - Gene mapping KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20810666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wound+Repair+and+Regeneration&rft.atitle=Mouse+chromosome+9+quantitative+trait+loci+for+soft+tissue+regeneration%3A+Congenic+analysis+and+fine+mapping&rft.au=Yu%2C+Hongrun%3BBaylink%2C+David+J%3BMasinde%2C+Godfred+L%3BLi%2C+Runzhi%3BNguyen%2C+Bay%3BDavidson%2C+Heather+M%3BXu%2C+Shizhong%3BMohan%2C+Subburaman&rft.aulast=Yu&rft.aufirst=Hongrun&rft.date=2007-11-01&rft.volume=15&rft.issue=6&rft.spage=922&rft.isbn=&rft.btitle=&rft.title=Wound+Repair+and+Regeneration&rft.issn=10671927&rft_id=info:doi/10.1111%2Fj.1524-475X.2007.00317.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - chromosome 9; Quantitative trait loci; Mathematical models; Gene therapy; Bayesian analysis; Wound healing; Atrophy; Ear; genomics; Soft tissues; Gene mapping DO - http://dx.doi.org/10.1111/j.1524-475X.2007.00317.x ER - TY - JOUR T1 - In vivo leukocyte labeling with intravenous ferumoxides/protamine sulfate complex and in vitro characterization for cellular magnetic resonance imaging AN - 20599365; 7928462 AB - Cellular labeling with ferumoxides (Feridex IV) superparamagnetic iron oxide nanoparticles can be used to monitor cells in vivo by MRI. The objective of this study was to use histology and MRI to evaluate an in vivo, as opposed to in vitro, technique for labeling of mononuclear leukocytes as a means of tracking inflammatory processes in the brain. Long-Evans rats were intravenously injected with 20 mg/kg ferumoxides, ferumoxtran-10, or ferumoxytol with or without protamine sulfate. Leukocytes and splenocytes were evaluated by cell sorting and iron histochemistry or were implanted into the brain for MRI. Injection of ferumoxides/protamine sulfate complex IV resulted in iron labeling of leukocytes (ranging from 7.4 plus or minus 0.5% to 12.5 plus or minus 0.9% with average 9.2 plus or minus 0.8%) compared with ferumoxides (ranging from 3.9 plus or minus 0.4% to 6.3 plus or minus 0.5% with average 5.0 plus or minus 0.5%) or protamine sulfate alone (ranging from 0% to 0.9 plus or minus 0.7% with average 0.3 plus or minus 0.3%). Cell sorting analysis indicated that iron-labeled cells were enriched for cell types positive for the myelomonocytic marker (CD11b/c) and the B lymphocyte marker (CD45RA) and depleted in the T cell marker (CD3). Neither ferumoxtran-10 nor ferumoxytol with protamine sulfate labeled leukocytes. In vivo ferumoxides/protamine sulfate-loaded leukocytes and splenocytes were detected by MRI after intracerebral injection. Ferumoxides/protamine complex labeled CD45RA-positive and CD11b/c-positive leukocytes in vivo without immediate toxicity. The dose of feumoxides in this report is much higher than the approved human dose, so additional animal studies are required before this approach could be translated to the clinic. These results might provide useful information for monitoring leukocyte trafficking into the brain. JF - American Journal of Physiology: Cell Physiology AU - Wu, YJeffrey AU - Muldoon, Leslie L AU - Varallyay, Csanad AU - Markwardt, Sheila AU - Jones, Richard E AU - Neuwelt, Edward A AD - Research Service, Veterans Administration Medical Center, and Departments of Neurology, Cell and Developmental Biology, and Neurosurgery, Oregon Health and Sciences University, Portland, Oregon Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - C1698 EP - C1708 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 293 IS - 5 SN - 0363-6143, 0363-6143 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Leukocytes (mononuclear) KW - Intravenous administration KW - iron oxides KW - Lymphocytes B KW - Magnetic resonance imaging KW - Leukocytes KW - Brain KW - Cytochrome-c oxidase KW - Toxicity KW - Inflammation KW - Leukocyte migration KW - Splenocytes KW - CD45RA antigen KW - protamine KW - CD11b antigen KW - Lymphocytes T KW - protamine sulfate KW - CD3 antigen KW - nanoparticles KW - Iron KW - Histochemistry KW - W 30910:Imaging KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20599365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Cell+Physiology&rft.atitle=In+vivo+leukocyte+labeling+with+intravenous+ferumoxides%2Fprotamine+sulfate+complex+and+in+vitro+characterization+for+cellular+magnetic+resonance+imaging&rft.au=Wu%2C+YJeffrey%3BMuldoon%2C+Leslie+L%3BVarallyay%2C+Csanad%3BMarkwardt%2C+Sheila%3BJones%2C+Richard+E%3BNeuwelt%2C+Edward+A&rft.aulast=Wu&rft.aufirst=YJeffrey&rft.date=2007-11-01&rft.volume=293&rft.issue=5&rft.spage=C1698&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Cell+Physiology&rft.issn=03636143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Leukocytes (mononuclear); Intravenous administration; iron oxides; Lymphocytes B; Leukocytes; Magnetic resonance imaging; Brain; Cytochrome-c oxidase; Toxicity; Inflammation; Leukocyte migration; Splenocytes; CD45RA antigen; protamine; CD11b antigen; Lymphocytes T; protamine sulfate; CD3 antigen; Histochemistry; Iron; nanoparticles ER - TY - JOUR T1 - Tuberculosis and multidrug resistance in Zambian prisons, 2000-2001 AN - 20482326; 7965037 AB - BACKGROUND: Data on prevalence of tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB) in Zambian prisons are lacking. METHODS: Between January 2000 and July 2001, a case-finding study was performed in 13 Zambian prisons for pulmonary TB. Prisoners were administered a questionnaire to obtain demographic information. Information regarding housing density and diet was also collected. Three consecutive first morning sputum specimens were cultured for Mycobacterium tuberculosis. Antimicrobial resistance testing was performed by the resistance ratio method. RESULTS: A total of 1080 prisoners were recruited: 1055 were males and 25 females. Sputum from 245 (22.7%) prisoners yielded M. tuberculosis, including 168 (15.6%) with smear-positive disease. Based on a total prison population of 6118, the minimal prevalence of TB was 4.0%. There was a linear relationship between the proportion of prisoners evaluated and the prevalence of TB (R super(2) = 0.9366) across facilities, suggesting that the true prevalence of TB may approach 15-20%. Resistance to at least one anti-tuberculosis drug was detected for 40 (23.8%) isolates, while MDR-TB was identified for 16 (9.5%) isolates. CONCLUSION: There is a high rate of pulmonary TB in Zambian prisons, with significant rates of drug resistance and MDR-TB, highlighting the need for active surveillance and treatment programs. JF - International Journal of Tuberculosis and Lung Disease AU - Habeenzu, C AU - Mitarai, S AU - Lubasi, D AU - Mudenda, V AU - Kantenga, T AU - Mwansa, J AU - Maslow, J N AD - Veteran Affairs Medical Center, University and Woodland Aves, Philadelphia, PA 19104, USA, joel.maslow@va.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1216 EP - 1220 VL - 11 IS - 11 SN - 1027-3719, 1027-3719 KW - Microbiology Abstracts B: Bacteriology KW - Diets KW - Demography KW - Prisons KW - Inventories KW - Housing KW - Drug resistance KW - Lung diseases KW - Tuberculosis KW - Multidrug resistance KW - Sputum KW - Mycobacterium tuberculosis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20482326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Tuberculosis+and+multidrug+resistance+in+Zambian+prisons%2C+2000-2001&rft.au=Habeenzu%2C+C%3BMitarai%2C+S%3BLubasi%2C+D%3BMudenda%2C+V%3BKantenga%2C+T%3BMwansa%2C+J%3BMaslow%2C+J+N&rft.aulast=Habeenzu&rft.aufirst=C&rft.date=2007-11-01&rft.volume=11&rft.issue=11&rft.spage=1216&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Demography; Diets; Inventories; Prisons; Housing; Drug resistance; Lung diseases; Multidrug resistance; Tuberculosis; Sputum; Mycobacterium tuberculosis ER - TY - JOUR T1 - Effusive Constrictive Pericarditis: 2D, 3D Echocardiography and MRI Imaging AN - 20170010; 7980838 AB - The entity of effusive constrictive pericarditis (ECP) combines clinical and echocardiographic features of pericardial effusion and constrictive pericarditis. We describe a case of ECP, of probable tuberculous etiology, with typical hemodynamic findings of pericardial constriction, which persisted after the pericardial effusion was drained. Thickening of parietal and visceral pericardium was seen on 2D and 3D echo, and on MRI. Two important variations of ECP-due to tuberculous and to staphylococcal etiology, respectively-show some important differences that are relevant to management of therapy. JF - Echocardiography AU - Zagol, Brian AU - Minderman, Daniel AU - Munir, Ahmad AU - D'Cruz, Ivan AD - University of Tennessee Health Science Center, Memphis, Tennessee, daniel.minderman@med.va.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1110 EP - 1114 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 24 IS - 10 SN - 0742-2822, 0742-2822 KW - Microbiology Abstracts B: Bacteriology KW - effusive constrictive pericarditis KW - pericardial constriction KW - pericardial effusion KW - 3D echocardiography KW - 2D echocardiography KW - magnetic resonance imaging KW - Etiology KW - Pericarditis KW - Magnetic resonance imaging KW - Echocardiography KW - Effusion KW - Hemodynamics KW - Tuberculosis KW - Pericardium KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20170010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Echocardiography&rft.atitle=Effusive+Constrictive+Pericarditis%3A+2D%2C+3D+Echocardiography+and+MRI+Imaging&rft.au=Zagol%2C+Brian%3BMinderman%2C+Daniel%3BMunir%2C+Ahmad%3BD%27Cruz%2C+Ivan&rft.aulast=Zagol&rft.aufirst=Brian&rft.date=2007-11-01&rft.volume=24&rft.issue=10&rft.spage=1110&rft.isbn=&rft.btitle=&rft.title=Echocardiography&rft.issn=07422822&rft_id=info:doi/10.1111%2Fj.1540-8175.2007.00505.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Etiology; Pericarditis; Echocardiography; Magnetic resonance imaging; Hemodynamics; Effusion; Tuberculosis; Pericardium DO - http://dx.doi.org/10.1111/j.1540-8175.2007.00505.x ER - TY - JOUR T1 - Anthrax Vaccine and Public Health Policy AN - 19895063; 7928519 AB - The Centers for Disease Control and Prevention has classified Bacillus anthracis, the causative organism of anthrax, as a category A potential bioterrorism agent. There are critical shortcomings in the US anthrax vaccine program. Rather than depending on the private sector, the government must assume direct production of anthrax vaccine. The development of a capacity capable of preemptive immunization of the public against anthrax should be considered. JF - American Journal of Public Health AU - Weiss, Martin Meyer AU - Weiss, Peter D AU - Weiss, Joseph B AD - Martin Meyer Weiss is with the Veterans Administration, Sepulveda, Calif, and the School of Medicine, University of California, Los Angeles. Peter D. Weiss is with the School of Medicine, University of California, Los Angeles. Joseph B. Weiss is with the School of Medicine, University of California, San Diego Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1945 EP - 1951 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 11 SN - 0090-0036, 0090-0036 KW - Microbiology Abstracts B: Bacteriology; Sustainability Science Abstracts KW - vaccines KW - bioterrorism KW - Disasters KW - Disease control KW - anthrax KW - Bacillus anthracis KW - disease control KW - Immunization KW - private sector KW - Public health KW - immunization KW - prevention KW - Anthrax KW - Vaccines KW - M3 1010:Issues in Sustainable Development KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19895063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Anthrax+Vaccine+and+Public+Health+Policy&rft.au=Weiss%2C+Martin+Meyer%3BWeiss%2C+Peter+D%3BWeiss%2C+Joseph+B&rft.aulast=Weiss&rft.aufirst=Martin&rft.date=2007-11-01&rft.volume=97&rft.issue=11&rft.spage=1945&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - bioterrorism; Disease control; Anthrax; Vaccines; Immunization; Public health; immunization; vaccines; prevention; Disasters; anthrax; disease control; private sector; Bacillus anthracis ER - TY - JOUR T1 - Characterization of an immunodeficient mouse model of mucopolysaccharidosis type I suitable for preclinical testing of human stem cell and gene therapy AN - 19888006; 7750898 AB - Mucopolysaccharidosis type I (MPS-I or Hurler syndrome) is an inherited deficiency of the lysosomal glycosaminoglycan (GAG)-degrading enzyme alpha -l-iduronidase (IDUA) in which GAG accumulation causes progressive multi-system dysfunction and death. Early allogeneic hematopoietic stem cell transplantation (HSCT) ameliorates clinical features and extends life but is not available to all patients, and inadequately corrects its most devastating features including mental retardation and skeletal deformities. To test novel therapies, we characterized an immunodeficient MPS-I mouse model less likely to develop immune reactions to transplanted human or gene-corrected cells or secreted IDUA. In the liver, spleen, heart, lung, kidney and brain of NOD/SCID/MPS-I mice IDUA was undetectable, and reduced to half in heterozygotes. MPS-I mice developed marked GAG accumulation (3-38-fold) in these organs. Neuropathological examination showed GM sub(3) ganglioside accumulation in the striatum, cerebral peduncles, cerebellum and ventral brainstem of MPS-I mice. Urinary GAG excretion (6.5-fold higher in MPS-I mice) provided a non-invasive and reliable method suitable for serially following the biochemical efficacy of therapeutic interventions. We identified and validated using rigorous biostatistical methods, a highly reproducible method for evaluating sensorimotor function and motor skills development. This Rotarod test revealed marked abnormalities in sensorimotor integration involving the cerebellum, striatum, proprioceptive pathways, motor cortex, and in acquisition of motor coordination. NOD/SCID/MPS-I mice exhibit many of the clinical, skeletal, pathological and behavioral abnormalities of human MPS-I, and provide an extremely suitable animal model for assessing the systemic and neurological effects of human stem cell transplantation and gene therapeutic approaches, using the above techniques to measure efficacy. JF - Brain Research Bulletin AU - Garcia-Rivera, M F AU - Colvin-Wanshura, LE AU - Nelson AU - Nan, Z AU - Khan, SA AU - Rogers, T B AU - Maitra, I AU - Low, W C AU - Gupta, P AD - Veterans Administration Medical Center, Minneapolis, MN, USA, lowwalt@umn.edu Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 429 EP - 438 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 74 IS - 6 SN - 0361-9230, 0361-9230 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Motor skill KW - Animal models KW - Cerebellum KW - Immunodeficiency KW - Therapeutic applications KW - Glycosaminoglycans KW - Neostriatum KW - Severe combined immunodeficiency KW - Mental retardation KW - Heart KW - Cortex (motor) KW - Gene therapy KW - stem cell transplantation KW - Brain stem KW - Brain KW - Enzymes KW - Spleen KW - Gangliosides KW - Sensorimotor integration KW - Lung KW - Proprioception KW - Heterozygotes KW - Liver KW - Kidney KW - Mucopolysaccharidosis KW - Excretion KW - W 30905:Medical Applications KW - N3 11023:Neurogenetics KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19888006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research+Bulletin&rft.atitle=Characterization+of+an+immunodeficient+mouse+model+of+mucopolysaccharidosis+type+I+suitable+for+preclinical+testing+of+human+stem+cell+and+gene+therapy&rft.au=Garcia-Rivera%2C+M+F%3BColvin-Wanshura%2C+LE%3BNelson%3BNan%2C+Z%3BKhan%2C+SA%3BRogers%2C+T+B%3BMaitra%2C+I%3BLow%2C+W+C%3BGupta%2C+P&rft.aulast=Garcia-Rivera&rft.aufirst=M&rft.date=2007-11-01&rft.volume=74&rft.issue=6&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Brain+Research+Bulletin&rft.issn=03619230&rft_id=info:doi/10.1016%2Fj.brainresbull.2007.07.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Motor skill; Immunodeficiency; Cerebellum; Animal models; Therapeutic applications; Glycosaminoglycans; Neostriatum; Severe combined immunodeficiency; Mental retardation; Heart; Cortex (motor); Gene therapy; stem cell transplantation; Brain stem; Brain; Spleen; Enzymes; Gangliosides; Sensorimotor integration; Lung; Proprioception; Heterozygotes; Kidney; Liver; Mucopolysaccharidosis; Excretion DO - http://dx.doi.org/10.1016/j.brainresbull.2007.07.018 ER - TY - JOUR T1 - Chronic cigarette smoking and heavy drinking in human immunodeficiency virus: consequences for neurocognition and brain morphology AN - 19606186; 8602078 AB - Alcohol use disorders (AUD) and chronic cigarette smoking are common among individuals with human immunodeficiency virus infection (HIV). Concurrent AUD in HIV is related to greater abnormalities in brain morphology and neurocognition than either condition alone. However, the potential influence of chronic smoking on brain morphology and neurocognition in those concurrently afflicted with AUD and HIV has not been examined. The goal of this retrospective analysis was to determine if chronic smoking affected neurocognition and brain morphology in a subsample of HIV-positive non- treatment-seeking heavy drinking participants (HD+) from our earlier work. Regional volumetric and neurocognitive comparisons were made among age- equivalent smoking HD+(n = 17), nonsmoking HD+ (n = 27), and nonsmoking HIV-negative light drinking controls (n = 27) obtained from our original larger sample. Comprehensive neuropsychological assessment evaluated multiple neurocognitive domains of functioning and for potential psychiatric comorbidities. Quantitative volumetric measures of neocortical gray matter (GM), white matter (WM), subcortical structures, and sulcal and ventricular cerebral spinal fluid (CSF) were derived from high-resolution magnetic resonance images. The main findings were (1) smoking HD+ performed significantly worse than nonsmoking HD+ on measures of auditory-verbal (AV) learning, AV memory, and cognitive efficiency; (2) relative to controls, smoking HD+ demonstrated significantly lower neocortical GM volumes in all lobes except the occipital lobe, while nonsmoking HD+ showed only lower frontal GM volume compared with controls; (3) in the HD+ group, regional brain volumes and neurocognition were not influenced by viremia, highly active antiretroviral treatment, or Center for Disease Control symptom status, and no interactions were apparent with these variables or smoking status. Overall, the findings suggested that the direct and/or indirect effects of chronic cigarette smoking created an additional burden on the integrity of brain neurobiology and neurocognition in this cohort of HIV- positive heavy drinkers. JF - Alcohol AU - Durazzo, Timothy C AU - Rothlind, Johannes C AU - Cardenas, Valerie A AU - Studholme, Colin AU - Weiner, Michael W AU - Meyerhoff, Dieter J AD - Center for Neuroimaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, USA, timothy.durazzo@ucsf.edu Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 489 EP - 501 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 41 IS - 7 SN - 0741-8329, 0741-8329 KW - Virology & AIDS Abstracts; Toxicology Abstracts; CSA Neurosciences Abstracts KW - HIV KW - Alcohol use disorders KW - Chronic cigarette smoking KW - Neuroimaging KW - Neurocognition KW - Learning KW - Magnetic resonance imaging KW - Disease control KW - Brain KW - Substantia alba KW - Cognition KW - Light effects KW - Cerebrospinal fluid KW - Memory KW - Cortex KW - Antiviral agents KW - Human immunodeficiency virus KW - Cognitive ability KW - Cigarette smoking KW - Chronic infection KW - alcohols KW - Drinking behavior KW - Viremia KW - Occipital lobe KW - Substantia grisea KW - V 22360:AIDS and HIV KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19606186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol&rft.atitle=Chronic+cigarette+smoking+and+heavy+drinking+in+human+immunodeficiency+virus%3A+consequences+for+neurocognition+and+brain+morphology&rft.au=Durazzo%2C+Timothy+C%3BRothlind%2C+Johannes+C%3BCardenas%2C+Valerie+A%3BStudholme%2C+Colin%3BWeiner%2C+Michael+W%3BMeyerhoff%2C+Dieter+J&rft.aulast=Durazzo&rft.aufirst=Timothy&rft.date=2007-11-01&rft.volume=41&rft.issue=7&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/10.1016%2Fj.alcohol.2007.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Learning; Magnetic resonance imaging; Brain; Disease control; Substantia alba; Cognition; Light effects; Memory; Cerebrospinal fluid; Cortex; Antiviral agents; Cognitive ability; Chronic infection; Cigarette smoking; alcohols; Drinking behavior; Occipital lobe; Viremia; Substantia grisea; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/j.alcohol.2007.07.007 ER - TY - JOUR T1 - Posttransplant Epstein-Barr virus related lymphoproliferative disorder with a primary cutaneous presentation. AN - 70125730; 18319004 AB - Posttransplant lymphoproliferative disorder is a rare and often difficult diagnosis in patients with only cutaneous symptoms. A stepwise approach to diagnosis and classification can lead to successful treatment. We report a case of an EBV-associated posttransplant lymphoproliferative disorder (PTLD) occurring on the face with a primary cutaneous presentation. The appropriate diagnosis was made only after multiple biopsies and special stains. There was near complete resolution with decreased levels of iatrogenic immunosuppression. The diagnosis of Posttransplant lymphoproliferative disorder can be difficult to establish. A proper workup will aid in making an accelerated diagnosis and choosing appropriate treatment options. JF - Dermatology online journal AU - Snavely, Nicholas R AU - Sonabend, Michael AU - Rosen, Ted AD - Michael E. DeBakey Veterans Administration Medical Center, Baylor College of Medicine, Houston, Texas, USA. Y1 - 2007/10/13/ PY - 2007 DA - 2007 Oct 13 SP - 7 VL - 13 IS - 4 KW - Immunosuppressive Agents KW - 0 KW - Mycophenolic Acid KW - HU9DX48N0T KW - Prednisone KW - VB0R961HZT KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Sirolimus -- adverse effects KW - Prednisone -- adverse effects KW - Immunosuppression -- adverse effects KW - Mycophenolic Acid -- analogs & derivatives KW - Dose-Response Relationship, Drug KW - Humans KW - Pulmonary Fibrosis -- surgery KW - Middle Aged KW - Mycophenolic Acid -- adverse effects KW - Face KW - Male KW - Lymphoproliferative Disorders -- etiology KW - Lung Transplantation KW - Skin Diseases -- etiology KW - Epstein-Barr Virus Infections -- complications KW - Immunosuppressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70125730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dermatology+online+journal&rft.atitle=Posttransplant+Epstein-Barr+virus+related+lymphoproliferative+disorder+with+a+primary+cutaneous+presentation.&rft.au=Snavely%2C+Nicholas+R%3BSonabend%2C+Michael%3BRosen%2C+Ted&rft.aulast=Snavely&rft.aufirst=Nicholas&rft.date=2007-10-13&rft.volume=13&rft.issue=4&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Dermatology+online+journal&rft.issn=1087-2108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-02 N1 - Date created - 2008-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - The Role of Complement Opsonization in the Phagocytosis of Francisella tularensis by Human Neutrophils. T2 - 40th Annual Meeting of the Society for Leukocyte Biology AN - 40698285; 4756036 JF - 40th Annual Meeting of the Society for Leukocyte Biology AU - Barker, J H Y1 - 2007/10/11/ PY - 2007 DA - 2007 Oct 11 KW - Opsonization KW - Leukocytes (neutrophilic) KW - Phagocytosis KW - Francisella tularensis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+Annual+Meeting+of+the+Society+for+Leukocyte+Biology&rft.atitle=The+Role+of+Complement+Opsonization+in+the+Phagocytosis+of+Francisella+tularensis+by+Human+Neutrophils.&rft.au=Barker%2C+J+H&rft.aulast=Barker&rft.aufirst=J&rft.date=2007-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+Annual+Meeting+of+the+Society+for+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.leukocytebiology.org/2007meeting/pdf/FINAL_Official%202007% 20SLB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Implementation of buprenorphine in the Veterans Health Administration: Results of the first 3 years AN - 57233660; 200804157 AB - Background Compared to non-veterans, veterans are disproportionately diagnosed with opioid dependence. Sublingual buprenorphine provides greater access to opioid agonist therapy. To understand the diffusion of this innovative treatment within a large healthcare system, we describe the introduction of buprenorphine within the Veterans Health Administration (VHA) during the first 3 years of its approval as a VHA non-formulary medication. Methods Using VHA pharmacy databases, we examined the number of physicians who have prescribed buprenorphine and the number of veterans who have received office-based buprenorphine within VHA veterans integrated service networks (VISN) from fiscal years (FY) 2003 through FY 2005 (October 2002 through September 2005). Results From FY2003 through FY2005 the number of veterans with opioid dependence increased from 25,031 to 26,859 (>7.3%) and the number of veterans prescribed office-based buprenorphine increased from 53 to 739. During this interval, 16 of 21 VISNs had prescribed buprenorphine. In FY2005, two VISNs accounted for 31% of buprenorphine prescriptions. The number of buprenorphine prescriptions varied widely by VISN, but increased from 212 to 7076 from FY2003 through FY2005. During this interval, prescriptions per patient increased from 4.0 to 9.6 and physicians prescribing buprenorphine increased from 14 to 170. The ratio of patients prescribed buprenorphine to providers prescribing buprenorphine increased from 3.8 to 4.3 with an average increase of 15.1-41.6 of prescriptions per provider. Conclusions VHA increased, but not uniformly, the non-formulary use of office-based buprenorphine during the first 3 years of availability. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Gordon, Adam J AU - Trafton, Jodie A AU - Saxon, Andrew J AU - Gifford, Allen L AU - Goodman, Francine AU - Calabrese, Vincent S AU - McNicholas, Laura AU - Liberto, Joseph AD - VISN 4 Mental Illness, Research, Education, and Clinical Center, Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Mailcode 151-C, University Drive C, Pittsburgh, PA 15240, United States adam.gordon@va.gov Y1 - 2007/10/08/ PY - 2007 DA - 2007 Oct 08 SP - 292 EP - 296 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 90 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Buprenorphine KW - Opioid dependence KW - Veterans administration KW - Treatment KW - Veterans KW - Opioids KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57233660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Implementation+of+buprenorphine+in+the+Veterans+Health+Administration%3A+Results+of+the+first+3+years&rft.au=Gordon%2C+Adam+J%3BTrafton%2C+Jodie+A%3BSaxon%2C+Andrew+J%3BGifford%2C+Allen+L%3BGoodman%2C+Francine%3BCalabrese%2C+Vincent+S%3BMcNicholas%2C+Laura%3BLiberto%2C+Joseph&rft.aulast=Gordon&rft.aufirst=Adam&rft.date=2007-10-08&rft.volume=90&rft.issue=2-3&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.03.010 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Buprenorphine; Opioids; Treatment; Veterans DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.03.010 ER - TY - JOUR T1 - Practical guidelines for the management of toxic epidermal necrolysis and Stevens-Johnson syndrome AN - 746160997; 7991243 AB - Toxic epidermal necrolysis and Stevens-Johnson syndrome are acute life-threatening dermatoses characterized by extensive sloughing and mucositis. At the University of Florida, we use practical guidelines for the management of these gravely ill patients. These can be of help to other practitioners. JF - International Journal of Dermatology AU - Fromowitz, Jeffrey S AU - Ramos-Caro, Francisco A AU - Flowers, Franklin P AD - From the Department of Medicine, Division of Dermatology and Cutaneous Surgery, University of Florida College of Medicine, and Dermatology and Cutaneous Surgery Section, Malcolm Randall Veterans Administration Medical Center, Gainesville, Florida, Ramosfa@medicine.ufl.edu Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1092 EP - 1094 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 46 IS - 10 SN - 0011-9059, 0011-9059 KW - Toxicology Abstracts KW - Mucositis KW - Stevens-Johnson syndrome KW - Toxic epidermal necrolysis KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746160997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Dermatology&rft.atitle=Practical+guidelines+for+the+management+of+toxic+epidermal+necrolysis+and+Stevens-Johnson+syndrome&rft.au=Fromowitz%2C+Jeffrey+S%3BRamos-Caro%2C+Francisco+A%3BFlowers%2C+Franklin+P&rft.aulast=Fromowitz&rft.aufirst=Jeffrey&rft.date=2007-10-01&rft.volume=46&rft.issue=10&rft.spage=1092&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Dermatology&rft.issn=00119059&rft_id=info:doi/10.1111%2Fj.1365-4632.2007.03277.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Mucositis; Stevens-Johnson syndrome; Toxic epidermal necrolysis DO - http://dx.doi.org/10.1111/j.1365-4632.2007.03277.x ER - TY - JOUR T1 - New molecular mechanisms of duodenal ulceration. AN - 68462655; 17656571 AB - Stress is a major etiologic factor in the pathogenesis of gastric and duodenal ulceration, as first described in rats by Hans Selye. In patients with "peptic ulcers" duodenal ulcers are more frequent than gastric ulcers (except in Japan). Thus, our research during the last three decades focused on the molecular mechanisms of duodenal ulcer in rodent models of chemically induced duodenal ulceration, and here we review our three recent findings: Endothelins (ET-1), the immediate early gene egr-1 and imbalance of angiogenic/antiangiogenic molecules. Namely, we found an enhanced expression and release of ET-1 within 15-30 min after the administration of duodenal ulcerogen cysteamine, resulting in local ischemia that triggers the expression of hypoxia-inducible factors (HIF-1alpha). Our gene expression studies also revealed an early (0.5-2 h) increase in the expression of egr-1 that is followed (12-24 h) by upregulation of angiogenic growth factors (e.g., VEGF, bFGF, PDGF). Surprisingly, this event is also associated with an enhanced production of angiostatin and endostatin that probably counteract the beneficial effect of angiogenic molecules. Thus, the initial injury to endothelial and epithelial cells in duodenal ulceration seems to be aggravated (and not initiated) by HCl and proteolytic enzymes. The resulting mucosal necrosis does not rapidly heal because of the imbalance of VEGF and angiostatin/endostatin, hence duodenal ulcers develop. The experimental ulcers Selye described morphologically are now characterized at the molecular and genome level, involving unexpected mediators like ET-1, egr-1 and angiogenesis-related molecules. JF - Annals of the New York Academy of Sciences AU - Szabo, Sandor AU - Deng, Xiaoming AU - Khomenko, Tetyana AU - Chen, Longchuan AU - Tolstanova, Ganna AU - Osapay, Klara AU - Sandor, Zsuzsanna AU - Xiong, Ximing AD - VA Medical Center, University of California-Irvine, School of Medicine, Long Beach, CA, USA. sandor.szabo@med.va.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 238 EP - 255 VL - 1113 SN - 0077-8923, 0077-8923 KW - Angiogenesis Inhibitors KW - 0 KW - Angiogenic Proteins KW - Early Growth Response Protein 1 KW - Endothelin-1 KW - Index Medicus KW - Animals KW - Angiogenesis Inhibitors -- physiology KW - Endothelin-1 -- secretion KW - Endothelin-1 -- genetics KW - Endothelin-1 -- biosynthesis KW - Humans KW - Early Growth Response Protein 1 -- physiology KW - Angiogenic Proteins -- physiology KW - Duodenal Ulcer -- pathology KW - Duodenal Ulcer -- chemically induced KW - Duodenal Ulcer -- etiology KW - Duodenal Ulcer -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68462655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=New+molecular+mechanisms+of+duodenal+ulceration.&rft.au=Szabo%2C+Sandor%3BDeng%2C+Xiaoming%3BKhomenko%2C+Tetyana%3BChen%2C+Longchuan%3BTolstanova%2C+Ganna%3BOsapay%2C+Klara%3BSandor%2C+Zsuzsanna%3BXiong%2C+Ximing&rft.aulast=Szabo&rft.aufirst=Sandor&rft.date=2007-10-01&rft.volume=1113&rft.issue=&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term, high-dose benzodiazepine prescriptions in veteran patients with PTSD: influence of preexisting alcoholism and drug-abuse diagnoses. AN - 68443232; 17955537 AB - Databases from the New England Veterans Integrated Service Network were analyzed to determine factors associated with long-term, high-dose anxiolytic benzodiazepine prescriptions dispensed to patients with posttraumatic stress disorder (PTSD) and existing alcoholism and/or drug abuse diagnoses. Among 2,183 PTSD patients, 234 received the highest 10% average daily doses for alprazolam, clonazepam, diazepam, or lorazepam, doses above those typically recommended. Highest doses were more commonly prescribed to patients with existing drug abuse diagnoses. Among patients with PTSD and alcoholism, younger age, drug abuse, and concurrent prescriptions for another benzodiazepine and oxycodone/acetaminophen independently predicted high doses. Results indicate that for veteran patients with PTSD, alcoholism alone is not associated with high-dose benzodiazepines, but existing drug abuse diagnoses do increase that risk. JF - Journal of traumatic stress AU - Hermos, John A AU - Young, Melissa M AU - Lawler, Elizabeth V AU - Rosenbloom, David AU - Fiore, Louis D AD - Pharmacoepidemiology Research Group, Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA 02130, USA. john.hermos@med.va.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 909 EP - 914 VL - 20 IS - 5 SN - 0894-9867, 0894-9867 KW - Anti-Anxiety Agents KW - 0 KW - Benzodiazepines KW - 12794-10-4 KW - Index Medicus KW - Medical Records KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - New England KW - Middle Aged KW - Long-Term Care KW - Male KW - Female KW - Comorbidity KW - Veterans KW - Substance-Related Disorders -- diagnosis KW - Anti-Anxiety Agents -- administration & dosage KW - Alcoholism -- diagnosis KW - Benzodiazepines -- administration & dosage KW - Stress Disorders, Post-Traumatic -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68443232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+traumatic+stress&rft.atitle=Long-term%2C+high-dose+benzodiazepine+prescriptions+in+veteran+patients+with+PTSD%3A+influence+of+preexisting+alcoholism+and+drug-abuse+diagnoses.&rft.au=Hermos%2C+John+A%3BYoung%2C+Melissa+M%3BLawler%2C+Elizabeth+V%3BRosenbloom%2C+David%3BFiore%2C+Louis+D&rft.aulast=Hermos&rft.aufirst=John&rft.date=2007-10-01&rft.volume=20&rft.issue=5&rft.spage=909&rft.isbn=&rft.btitle=&rft.title=Journal+of+traumatic+stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-01 N1 - Date created - 2007-10-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The future of vaccines in the management of addictive disorders. AN - 68345173; 17915077 AB - Conventional substance abuse treatments have had only limited success. As a result, new approaches, including vaccination to block the effects of drugs such as cocaine, nicotine, methamphetamine, and phencyclidine, are in development. Although a number of possible rationales for the effects of antidrug vaccines have been suggested, the most straightforward and intuitive mechanism would involve binding of the drug by antibodies in the bloodstream, thereby blocking entry or reducing the rate of entry of the drug into the central nervous system. The theoretical parameters that would influence vaccine-induced drug pharmacodynamics are presented in this review, along with the current status on vaccine development for nicotine, cocaine, methamphetamine, and phencyclidine. JF - Current psychiatry reports AU - Orson, Frank M AU - Kinsey, Berma M AU - Singh, Rana A K AU - Wu, Yan AU - Gardner, Tracie AU - Kosten, Thomas R AD - Veterans Administration Medical Center, 2002 Holcombe, Houston, TX 77030, USA. forson@bcm.tmc.edu Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 381 EP - 387 VL - 9 IS - 5 SN - 1523-3812, 1523-3812 KW - Antibodies, Blocking KW - 0 KW - Street Drugs KW - Vaccines KW - Index Medicus KW - Street Drugs -- immunology KW - Humans KW - Clinical Trials as Topic KW - Forecasting KW - Antibody Affinity -- immunology KW - Antibodies, Blocking -- immunology KW - Vaccines -- immunology KW - Vaccines -- therapeutic use KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68345173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+psychiatry+reports&rft.atitle=The+future+of+vaccines+in+the+management+of+addictive+disorders.&rft.au=Orson%2C+Frank+M%3BKinsey%2C+Berma+M%3BSingh%2C+Rana+A+K%3BWu%2C+Yan%3BGardner%2C+Tracie%3BKosten%2C+Thomas+R&rft.aulast=Orson&rft.aufirst=Frank&rft.date=2007-10-01&rft.volume=9&rft.issue=5&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Current+psychiatry+reports&rft.issn=15233812&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quality indicators for the care of stroke and atrial fibrillation in vulnerable elders. AN - 68340205; 17910567 JF - Journal of the American Geriatrics Society AU - Cheng, Eric M AU - Fung, Constance H AD - Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA. eric.cheng@va.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - S431 EP - S437 VL - 55 Suppl 2 SN - 0002-8614, 0002-8614 KW - Anticoagulants KW - 0 KW - Platelet Aggregation Inhibitors KW - Index Medicus KW - Thrombolytic Therapy KW - Evidence-Based Medicine KW - Platelet Aggregation Inhibitors -- therapeutic use KW - Anticoagulants -- therapeutic use KW - Humans KW - Hyperlipidemias -- therapy KW - Hyperlipidemias -- diagnosis KW - Alcohol Drinking -- adverse effects KW - Smoking -- adverse effects KW - Aged KW - Carotid Stenosis -- diagnosis KW - Depression -- diagnosis KW - Exercise KW - Process Assessment (Health Care) KW - Carotid Stenosis -- complications KW - Hormone Replacement Therapy -- adverse effects KW - Carotid Stenosis -- prevention & control KW - Hyperlipidemias -- complications KW - Health Behavior KW - Deglutition Disorders -- diagnosis KW - Secondary Prevention KW - Quality Indicators, Health Care KW - Stroke -- therapy KW - Frail Elderly KW - Stroke -- etiology KW - Atrial Fibrillation -- therapy KW - Atrial Fibrillation -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68340205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Quality+indicators+for+the+care+of+stroke+and+atrial+fibrillation+in+vulnerable+elders.&rft.au=Cheng%2C+Eric+M%3BFung%2C+Constance+H&rft.aulast=Cheng&rft.aufirst=Eric&rft.date=2007-10-01&rft.volume=55+Suppl+2&rft.issue=&rft.spage=S431&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-07 N1 - Date created - 2007-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Is the frequency of carisoprodol withdrawal syndrome increasing? AN - 68318028; 17896902 AB - Carisoprodol is a commonly used centrally acting muscle relaxant. A number of case reports have suggested that the drug may have abuse potential, presumably because it is metabolized to the anxiolytic drug, meprobamate, which is a controlled substance at the federal level. Two recent case reports described symptoms of withdrawal after the cessation of carisoprodol. We present two additional cases that support the concept of a withdrawal syndrome with this drug. Symptoms of carisoprodol withdrawal include anxiety, tremulousness, insomnia, jitteriness, muscle twitching, and hallucinations. These symptoms are most likely caused by withdrawal from the meprobamate that accumulates after large amounts of carisoprodol are ingested. Although carisoprodol is not a controlled substance at the federal level, clinicians should be aware of its significant potential for abuse. JF - Pharmacotherapy AU - Reeves, Roy R AU - Hammer, Jeffrey S AU - Pendarvis, Richard O AD - Mental Health Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Mississippi 39216, USA. roy.reeves@med.va.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1462 EP - 1466 VL - 27 IS - 10 SN - 0277-0008, 0277-0008 KW - Muscle Relaxants, Central KW - 0 KW - Tablets KW - Carisoprodol KW - 21925K482H KW - Meprobamate KW - 9I7LNY769Q KW - Index Medicus KW - Meprobamate -- metabolism KW - Self Administration KW - Muscle Relaxants, Central -- administration & dosage KW - Humans KW - Adult KW - Muscle Relaxants, Central -- adverse effects KW - Hallucinations -- etiology KW - Sleep Initiation and Maintenance Disorders -- etiology KW - Muscle Relaxants, Central -- metabolism KW - Female KW - Anxiety -- etiology KW - Carisoprodol -- adverse effects KW - Carisoprodol -- metabolism KW - Substance Withdrawal Syndrome -- metabolism KW - Substance Withdrawal Syndrome -- etiology KW - Carisoprodol -- administration & dosage KW - Substance Withdrawal Syndrome -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68318028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Is+the+frequency+of+carisoprodol+withdrawal+syndrome+increasing%3F&rft.au=Reeves%2C+Roy+R%3BHammer%2C+Jeffrey+S%3BPendarvis%2C+Richard+O&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2007-10-01&rft.volume=27&rft.issue=10&rft.spage=1462&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-13 N1 - Date created - 2007-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Postmarketing surveillance of corneal edema, Fuchs dystrophy, and amantadine use in the Veterans Health Administration. AN - 68308588; 17893540 AB - To determine the proportion of patients who were dispensed amantadine and diagnosed with corneal edema or Fuchs dystrophy within specified time frames. Postmarketing surveillance study. The national Veterans Health Administration pharmacy and clinical databases were used to identify a cohort of veterans without a prior history of corneal edema, Fuchs dystrophy, or a prescription for amantadine. During fiscal years 2005-2006, 2 databases were used to identify patients with new diagnoses of corneal disease and new prescriptions for amantadine. Patients from each were cross-referenced. The outcome measure was concurrent diagnosis of corneal edema or Fuchs dystrophy and new prescription for amantadine within specified intervals. Thirty-six (0.27%) patients among the 13,137 who were dispensed amantadine were diagnosed with corneal edema or Fuchs dystrophy within the 2-year study period. The relative risk of corneal edema for a person prescribed amantadine was 1.7 (95% confidence interval: 1.1-2.8). In 12 (0.09%) patients, the corneal diagnoses were recorded within a month of being prescribed amantadine. Retrospective examination of a large national medical database revealed that amantadine was temporally associated with a small proportion of patients diagnosed with corneal edema or Fuchs dystrophy. Although additional studies are needed to confirm the risk of corneal edema with amantadine, the development of corneal edema in persons prescribed amantadine warrants clinical attention. In such a situation, physicians may consider stopping amantadine to see if the edema subsides. JF - Cornea AU - French, Dustin D AU - Margo, Curtis E AD - VISN-8 Patient Safety Center of Inquiry, Tampa, FL 33613, USA. Dustin.French@med.va.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1087 EP - 1089 VL - 26 IS - 9 SN - 0277-3740, 0277-3740 KW - Antiparkinson Agents KW - 0 KW - Antiviral Agents KW - Amantadine KW - BF4C9Z1J53 KW - Index Medicus KW - United States KW - Pharmacy Service, Hospital -- statistics & numerical data KW - Risk Factors KW - Humans KW - Retrospective Studies KW - Databases, Factual KW - Aged KW - Middle Aged KW - Male KW - Female KW - Drug Prescriptions -- statistics & numerical data KW - Antiparkinson Agents -- adverse effects KW - Fuchs' Endothelial Dystrophy -- chemically induced KW - Product Surveillance, Postmarketing KW - Corneal Edema -- chemically induced KW - Amantadine -- adverse effects KW - Antiviral Agents -- adverse effects KW - United States Department of Veterans Affairs -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68308588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cornea&rft.atitle=Postmarketing+surveillance+of+corneal+edema%2C+Fuchs+dystrophy%2C+and+amantadine+use+in+the+Veterans+Health+Administration.&rft.au=French%2C+Dustin+D%3BMargo%2C+Curtis+E&rft.aulast=French&rft.aufirst=Dustin&rft.date=2007-10-01&rft.volume=26&rft.issue=9&rft.spage=1087&rft.isbn=&rft.btitle=&rft.title=Cornea&rft.issn=02773740&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-03 N1 - Date created - 2007-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment processes and mediators of substance use disorders treatment effects: the benefits of side road excursions. AN - 68292305; 17880353 AB - This article provides some commentary on six brief presentations on treatment processes and mediators of substance use disorder (SUD) treatment effects that were made at the 2005 Research Society on Alcoholism Satellite Preconference on "The Search for Mechanisms of Change in Evidence-Based Behavioral Treatments." Six presentations are discussed. The foci of the presentations ranged from the linkages of intermediate outcomes of cognitive-behavioral and 12-step treatment (e.g., spirituality) to posttreatment substance use to the relationship between treatment completion of brief motivational interviewing and treatment outcome. None of the six presentations met all or even most of the criteria for analyses of mediation of intervention effects outlined by Kazdin and Nock. In fact, some did not examine mediation at all. However, the presentations were valuable in illustrating that important new knowledge can be gained from addressing SUD treatment processes and mechanisms of treatment change. Given the paucity of extant research on mediation of SUD treatment effects, correlational explorations of treatment processes and treatment mediators are useful at this point, even though most mediational analyses do not meet many of the criteria listed by Kazdin and Nock. More attention should be devoted to assessing mediators before the assessment of outcome variables (e.g., during treatment) in order to address temporal precedence. Only after reasonable evidence has accrued regarding statistical mediation (expected associations, temporal precedence, reduction in treatment effects when putative mediator is controlled) does it make sense to mount expensive studies with experimental designs to examine causal mediation effects. JF - Alcoholism, clinical and experimental research AU - Finney, John W AD - Center for Health Care Evaluation, VA Palo Alto Health Care System, Menlo Park Division 152, 795 Wiillow Road, Menlo Park, CA 94025, USA. John.Finney@va.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 80s EP - 83s VL - 31 IS - 10 Suppl SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Patient Compliance -- psychology KW - Humans KW - Spirituality KW - Self-Help Groups KW - Substance-Related Disorders -- therapy KW - Psychotherapy KW - Outcome and Process Assessment (Health Care) KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68292305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Treatment+processes+and+mediators+of+substance+use+disorders+treatment+effects%3A+the+benefits+of+side+road+excursions.&rft.au=Finney%2C+John+W&rft.aulast=Finney&rft.aufirst=John&rft.date=2007-10-01&rft.volume=31&rft.issue=10+Suppl&rft.spage=80s&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-08 N1 - Date created - 2007-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nurses improve medication safety with medication allergy and adverse drug reports. AN - 68280421; 17873729 AB - Medicine-related illnesses cost more than 75 billion dollars annually. Adverse drug reactions (ADRs) are the fourth to sixth leading causes of death in the United States. An educational campaign to reduce ADRs and improve documentation included (1) an allergy awareness campaign, (2) staff nurses' training on documentation of allergies/ADRs, (3) patient-oriented brochures to encourage allergy reporting and ADRs, and (4) a fact sheet about ADRs. As a result, the documentation of medication allergies and ADRs improved significantly in our organization. JF - Journal of nursing care quality AU - Valente, Sharon AU - Murray, Lillian AU - Fisher, Diane AD - Veterans Affairs Greater Los Angeles Healthcare System, California, USA. sharon.valente@va.gov PY - 2007 SP - 322 EP - 327 VL - 22 IS - 4 SN - 1057-3631, 1057-3631 KW - Index Medicus KW - Nursing KW - Documentation KW - Drug-Related Side Effects and Adverse Reactions KW - Humans KW - Nursing Education Research KW - Nursing Records KW - Cause of Death KW - Cost of Illness KW - Nursing Audit KW - United States Department of Veterans Affairs KW - Health Knowledge, Attitudes, Practice KW - Nursing Evaluation Research KW - Adverse Drug Reaction Reporting Systems -- organization & administration KW - Nurse's Role KW - Program Evaluation KW - Total Quality Management -- organization & administration KW - Pamphlets KW - United States -- epidemiology KW - Hospitals, Veterans KW - Nursing Staff, Hospital -- psychology KW - Drug Therapy -- nursing KW - Nursing Staff, Hospital -- education KW - Patient Education as Topic -- organization & administration KW - Drug Hypersensitivity -- epidemiology KW - Education, Nursing, Continuing -- organization & administration KW - Drug Hypersensitivity -- prevention & control KW - Safety Management -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68280421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nursing+care+quality&rft.atitle=Nurses+improve+medication+safety+with+medication+allergy+and+adverse+drug+reports.&rft.au=Valente%2C+Sharon%3BMurray%2C+Lillian%3BFisher%2C+Diane&rft.aulast=Valente&rft.aufirst=Sharon&rft.date=2007-10-01&rft.volume=22&rft.issue=4&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Journal+of+nursing+care+quality&rft.issn=10573631&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-29 N1 - Date created - 2007-09-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical Evidence in Guardianship of Older Adults Is Inadequate: Findings from a Tri-State Study AN - 61787020; 200941303 AB - Purpose: This preliminary study compared clinical evaluations for guardianship in three states with varying levels of statutory reform. Design and Methods: Case files for 298 cases of adult guardianship were reviewed in Massachusetts, Pennsylvania, and Colorado, three states with varying degrees of statutory reform. The quality and content of the written clinical evidence for guardianship and the hearing outcome were recorded. Results: The quality of the written clinical evidence for guardianship was best in Colorado, the state with the most progressive statutory reform, earning a grade of B in our ratings, and worst in Massachusetts, a state with minimal reform, earning a grade of D -- with nearly two thirds of the written evidence illegible. Information on specific functional deficits was frequently missing and conclusory statements were common. Information about the individual's key values and preferences was almost never provided, and individuals were rarely present at the hearing. Limited orders were used for 34% of the cases in Colorado, associated with more complete clinical testimony, but such orders were used in only 1 case in either Massachusetts or Pennsylvania. Implications: In this study, states with progressive statutes that promote functional assessment are associated with increased quality of clinical testimony and use of limited orders. A continuing dialogue between clinical and legal professionals is needed to advance reform in guardianship, and thereby provide for the needs and protect the rights of adults who face guardianship proceedings. Adapted from the source document. JF - The Gerontologist AU - Moye, Jennifer AU - Wood, Stacey AU - Edelstein, Barry AU - Armesto, Jorge C AU - Bower, Emily H AU - Harrison, Julie A AU - Wood, Erica AD - VA Medical Center, Brockton, MA jennifer.moye@va.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 604 EP - 612 PB - Gerontological Society of America, Washington DC VL - 47 IS - 5 SN - 0016-9013, 0016-9013 KW - Evaluation KW - Self Care KW - Statutes KW - Guardianship KW - Independent Living KW - Elderly KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61787020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=Clinical+Evidence+in+Guardianship+of+Older+Adults+Is+Inadequate%3A+Findings+from+a+Tri-State+Study&rft.au=Moye%2C+Jennifer%3BWood%2C+Stacey%3BEdelstein%2C+Barry%3BArmesto%2C+Jorge+C%3BBower%2C+Emily+H%3BHarrison%2C+Julie+A%3BWood%2C+Erica&rft.aulast=Moye&rft.aufirst=Jennifer&rft.date=2007-10-01&rft.volume=47&rft.issue=5&rft.spage=604&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-10-02 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Guardianship; Evaluation; Elderly; Statutes; Self Care; Independent Living ER - TY - JOUR T1 - A Conceptual Model and Assessment Template for Capacity Evaluation in Adult Guardianship AN - 61426867; 200907381 AB - Purpose:NBWe develop a conceptual model and associated assessment template that is usable across state jurisdictions for evaluating the independent-living capacity of older adults in guardianship proceedings.NBDesign and Methods:NBWe used an iterative process in which legal provisions for guardianship and prevailing clinical practices for capacity assessment were integrated, through expert group consensus and external review by legal and health care professionals, to form a conceptual model and template.NBResults:NBThe model and template provide a structure for conducting and documenting a capacity evaluation in guardianship by using six assessment domains of interest to the courts: (1) medical condition, (2) cognition, (3) functional abilities, (4) values, (5) risk of harm and level of supervision needed, and (6) means to enhance capacity. The template also addresses the participation of the person in the guardianship hearing, confidentiality and privilege issues, and certification by the examiner. An online version of the template can be adapted to address specific jurisdictional requirements.NBImplications:NBA conceptual model and evaluation template provide a useful cross-jurisdictional format for conducting and documenting capacity assessments of older adults in guardianship proceedings. The template may be particularly useful to clinicians for providing courts with information to support limited guardianship orders. Adapted from the source document. JF - The Gerontologist AU - Moye, Jennifer AU - Butz, Steven W AU - Marson, Daniel C AU - Wood, Erica AU - ABA-APA Capacity Assessment Older Adults Working Group AD - VA Medical Center, Brockton, MA jennifer.moye@va.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 591 EP - 603 PB - Gerontological Society of America, Washington DC VL - 47 IS - 5 SN - 0016-9013, 0016-9013 KW - Capacity, Competency, Dementia, Guardianship KW - Evaluation KW - Competence KW - Self Care KW - Guardianship KW - Senility KW - Independent Living KW - Elderly KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61426867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=A+Conceptual+Model+and+Assessment+Template+for+Capacity+Evaluation+in+Adult+Guardianship&rft.au=Moye%2C+Jennifer%3BButz%2C+Steven+W%3BMarson%2C+Daniel+C%3BWood%2C+Erica%3BABA-APA+Capacity+Assessment+Older+Adults+Working+Group&rft.aulast=Moye&rft.aufirst=Jennifer&rft.date=2007-10-01&rft.volume=47&rft.issue=5&rft.spage=591&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2009-10-02 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Elderly; Evaluation; Senility; Self Care; Independent Living; Guardianship; Competence ER - TY - JOUR T1 - Improving Medicare Coverage of Psychological Services for Older Americans AN - 57244262; 200819705 AB - Professional psychology's ability to meet older Americans' psychological needs and to simultaneously thrive as a profession will be closely tied to the federal Medicare program over the coming decades. Despite legislative changes in the 1980s providing professional autonomy to psychologists and expanding coverage for mental health services, Medicare coverage policies, reimbursement mechanisms, and organizational traditions continue to limit older Americans' access to psychological services. This article describes how psychologists can influence Medicare coverage policy. Specifically, the authors examine widely unrecognized policy processes and recent political developments and analyze the recent creation of a new Medicare counseling benefit, applying J. W. Kingdon's (1995) well-known model of policy change. These recent developments offer new opportunities for expanding Medicare coverage of psychological services, particularly in the areas of prevention, screening, and early intervention. The article provides an analysis to guide psychologists in engaging in strategic advocacy and incorporating psychological prevention and early intervention services into Medicare. As Medicare policy entrepreneurs, psychologists can improve the well-being of millions of Americans who rely on the national health insurance program and, in so doing, can help shape the future practice of psychology. [Copyright 2007 The American Psychological Association.] JF - American Psychologist AU - Karlin, Bradley E AU - Humphreys, Keith AD - Office of Mental Health Services (116), VA Central Office, 810 Vermont Avenue, NW, Washington, DC 20420 bradley.karlin2@va.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 637 EP - 649 PB - American Psychological Association, Washington DC VL - 62 IS - 7 SN - 0003-066X, 0003-066X KW - Medicare, geriatric care, prevention, public policy, advocacy KW - Psychological services KW - Medicare KW - Older people KW - Health insurance KW - Access KW - Preventive mental health care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57244262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Psychologist&rft.atitle=Improving+Medicare+Coverage+of+Psychological+Services+for+Older+Americans&rft.au=Karlin%2C+Bradley+E%3BHumphreys%2C+Keith&rft.aulast=Karlin&rft.aufirst=Bradley&rft.date=2007-10-01&rft.volume=62&rft.issue=7&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=American+Psychologist&rft.issn=0003066X&rft_id=info:doi/10.1037%2F0003-066X.62.7.637 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Older people; Medicare; Psychological services; Access; Health insurance; Preventive mental health care DO - http://dx.doi.org/10.1037/0003-066X.62.7.637 ER - TY - JOUR T1 - The Opioid Renewal Clinic: A Primary Care, Managed Approach to Opioid Therapy in Chronic Pain Patients at Risk for Substance Abuse AN - 20734807; 8003574 AB - Objective. To measure the impact of a structured opioid renewal program for chronic pain run by a nurse practitioner (NP) and clinical pharmacist in a primary care setting. Patients and Setting. Patients with chronic noncancer pain managed with opioid therapy in a primary care clinic staffed by 19 providers serving 50,000 patients at an urban academic Veterans hospital. Design. Naturalistic prospective outcome study. Intervention. Based on published opioid prescribing guidelines and focus groups with primary care providers (PCPs), a structured program, the Opioid Renewal Clinic (ORC), was designed to support PCPs managing patients with chronic noncancer pain requiring opioids. After training in the use of opioid treatment agreements (OTAs) and random urine drug testing (UDT), PCPs worked with a pharmacist-run prescription management clinic supported by an onsite pain NP who was backed by a multi-specialty Pain Team. After 2 years, the program was evaluated for its impact on PCP practice and satisfaction, patient adherence, and pharmacy cost. Results. A total of 335 patients were referred to the ORC. Of the 171 (51%) with documented aberrant behaviors, 77 (45%) adhered to the OTA and resolved their aberrant behaviors, 65 (38%) self-discharged, 22 (13%) were referred for addiction treatment, and seven (4%) with consistently negative UDT were weaned from opioids. The 164 (49%) who were referred for complexity including history of substance abuse or need for opioid rotation or titration, with no documented aberrant drug-related behaviors, continued to adhere to the OTA. Use of UDT and OTAs by PCPs increased. Significant pharmacy cost savings were demonstrated. Conclusion. An NP-clinical pharmacist-run clinic, supported by a multi-specialty team, can successfully support a primary care practice in managing opioids in complex chronic pain patients. JF - Pain Medicine AU - Wiedemer, Nancy L AU - Harden, Paul S AU - Arndt, Isabelle O AU - Gallagher, Rollin M AD - Philadelphia VA Medical Center, Philadelphia, Pennsylvania; , nancy.wiedemer@med.va.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 573 EP - 584 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 8 IS - 7 SN - 1526-2375, 1526-2375 KW - Risk Abstracts KW - Opioids KW - Primary Care KW - Chronic Noncancer Pain KW - Substance Abuse KW - Pharmacy Costs KW - Pain Medicine KW - substance abuse KW - Historical account KW - Urine KW - guidelines KW - Training KW - intervention KW - pain KW - nursing KW - Drugs KW - Medical personnel KW - Hospitals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20734807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain+Medicine&rft.atitle=The+Opioid+Renewal+Clinic%3A+A+Primary+Care%2C+Managed+Approach+to+Opioid+Therapy+in+Chronic+Pain+Patients+at+Risk+for+Substance+Abuse&rft.au=Wiedemer%2C+Nancy+L%3BHarden%2C+Paul+S%3BArndt%2C+Isabelle+O%3BGallagher%2C+Rollin+M&rft.aulast=Wiedemer&rft.aufirst=Nancy&rft.date=2007-10-01&rft.volume=8&rft.issue=7&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Pain+Medicine&rft.issn=15262375&rft_id=info:doi/10.1111%2Fj.1526-4637.2006.00254.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - substance abuse; Historical account; Training; guidelines; Urine; intervention; pain; Drugs; nursing; Medical personnel; Hospitals DO - http://dx.doi.org/10.1111/j.1526-4637.2006.00254.x ER - TY - JOUR T1 - Psychiatric Comorbidity and Greater Hospitalization Risk, Longer Length of Stay, and Higher Hospitalization Costs in Older Adults with Heart Failure AN - 20734152; 7993739 AB - OBJECTIVESTo explore associations between psychiatric comorbidity and rehospitalization risk, length of hospitalization, and costs. DESIGNCross-sectional study of 1-year hospital administrative data. SETTINGClaims-based study of older adults hospitalized in the United States. PARTICIPANTSTwenty-one thousand four hundred twenty-nine patients from a 5% national random sample of U.S. Medicare beneficiaries aged 65 and older, with at least one acute care hospitalization in 1999 with a Diagnostic-Related Group of congestive heart failure. MEASUREMENTSThe number of hospitalizations, mean length of hospital stay, and total hospitalization costs in calendar year 1999. RESULTSOverall, 15.8% of patients hospitalized for heart failure (HF) had a coded psychiatric comorbidity; the most commonly coded comorbid psychiatric disorder was depression (8.5% of the sample). Most forms of psychiatric comorbidity were associated with greater inpatient utilization, including risk of additional hospitalizations, days of stay, and hospitalization charges. Additional hospitalization costs associated with psychiatric comorbidity ranged up to $7,763, and additional days length of stay ranged up to 1.4 days. CONCLUSIONPsychiatric comorbidity appears in a significant minority of patients hospitalized for HF and may affect their clinical and economic outcomes. The associations between psychiatric comorbidity and use of inpatient care are likely to be an underestimate, because psychiatric illness is known to be underdetected in older adults and in hospitalized medical patients. JF - Journal of the American Geriatrics Society AU - Sayers, Steven L AU - Hanrahan, Nancy AU - Kutney, Ann AU - Clarke, Sean P AU - Reis, Brendali F AU - Riegel, Barbara AD - VISN 4 Mental Illness, Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, steven.sayers@va.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1585 EP - 1591 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 55 IS - 10 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - heart failure KW - psychiatric comorbidity KW - depression KW - hospitalization costs KW - economic analysis KW - Medicare KW - sex KW - socioeconomic status KW - race-ethnicity KW - USA KW - Economics KW - mental disorders KW - Morbidity KW - Hospitals KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20734152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Psychiatric+Comorbidity+and+Greater+Hospitalization+Risk%2C+Longer+Length+of+Stay%2C+and+Higher+Hospitalization+Costs+in+Older+Adults+with+Heart+Failure&rft.au=Sayers%2C+Steven+L%3BHanrahan%2C+Nancy%3BKutney%2C+Ann%3BClarke%2C+Sean+P%3BReis%2C+Brendali+F%3BRiegel%2C+Barbara&rft.aulast=Sayers&rft.aufirst=Steven&rft.date=2007-10-01&rft.volume=55&rft.issue=10&rft.spage=1585&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2007.01368.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Economics; depression; mental disorders; Morbidity; Hospitals; USA DO - http://dx.doi.org/10.1111/j.1532-5415.2007.01368.x ER - TY - JOUR T1 - The continuing challenge of ESBLs AN - 20384443; 7792689 AB - Since their first description more than 20 years ago, Escherichia coli and Klebsiella pneumoniae possessing extended-spectrum class A beta-lactamases (ESBLs) continue to thwart our best clinical efforts. In the 'early years' the most common beta-lactamases were of the TEM and SHV varieties. Now, CTX-M enzymes are being discovered throughout the world and are becoming the most prevalent beta-lactamases found in clinical isolates. The K. pneumoniae carbapenemases (KPC) (ESBL-type enzymes that confer resistance to extended-spectrum cephalosporins and carbapenems) present the most significant challenge to date. Structural studies of ESBLs indicate that active site expansion and remodeling are responsible for this extended hydrolytic activity. Continuing questions still exist regarding the optimal detection method for ESBLs. Most relevant are the increasing concerns regarding the status of carbapenems as 'best therapy' for ESBL-producing bacteria in light of the emergence of carbapenemases. JF - Current Opinion in Pharmacology AU - Perez, F AU - Endimiani, A AU - Hujer, K M AU - Bonomo, R A AD - Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA, robert.bonomo@med.va.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 459 EP - 469 VL - 7 IS - 5 SN - 1471-4892, 1471-4892 KW - Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Cephalosporins KW - Reviews KW - Escherichia coli KW - Carbapenems KW - Enzymes KW - carbapenemase KW - Klebsiella pneumoniae KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20384443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Pharmacology&rft.atitle=The+continuing+challenge+of+ESBLs&rft.au=Perez%2C+F%3BEndimiani%2C+A%3BHujer%2C+K+M%3BBonomo%2C+R+A&rft.aulast=Perez&rft.aufirst=F&rft.date=2007-10-01&rft.volume=7&rft.issue=5&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Pharmacology&rft.issn=14714892&rft_id=info:doi/10.1016%2Fj.coph.2007.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Cephalosporins; Reviews; Enzymes; Carbapenems; carbapenemase; Escherichia coli; Klebsiella pneumoniae DO - http://dx.doi.org/10.1016/j.coph.2007.08.003 ER - TY - JOUR T1 - Human Allogeneic and Murine Xenogeneic Dendritic Cells Are Cytotoxic to Human Tumor Cells via Two Distinct Pathways AN - 20027691; 7792650 AB - Human monocyte-derived dendritic cells (DCs), stimulated with granulocyte-macrophage colony-stimulating factor and interleukin-4 for 1 week, killed human tumor cells in 24-hour cytotoxicity assays. These immature DCs were >90% CDllc, major histocompatibility complex class II super(+), but <1% were CD83 super(+) cells. Within 24 hours, these DCs ingested tumor membranes. The DC cells also lysed Jurkat lymphoma cells, but not Jurkat cells genetically knocked out of the Fas-associated death domain (FADD) or cas-pase-8. DC2.4, a cloned murine DC line, also displayed cytotoxicity toward U-251 cells, although these murine DCs were less potent than human DC. DC2.4 did not kill Jurkat cells, rat T9 glioma cells, or human Caco-2 colon cancer cells, suggesting that a unique receptor or ligand interaction exists between the DC and U-251 cells. This interaction was destroyed by prior paraformaldehyde fixation of the tumor cells. Supernatants from the cultures ofDC2.4 and tumor cells were analyzed by the Griess reaction for signs of nitric oxide (NO) production. Augmented NO production occurred in DC2.4/U-251 and DC2.4/Jurkat cultures but was not seen in the human DC/U-251 cultures. These studies suggest that DCs possess different mechanisms of tumoricidal activity. JF - Cancer Biotherapy and Radiopharmaceuticals AU - Schiltz, P M AU - Lee, G J AU - Zhang, J G AU - Hoa, N AU - Wepsic, H T AU - Dillman, RO AU - Jadus, M R AD - Box 113, Diagnostics and Molecular Medicine Health Care Group, Veterans Affairs Medical Center; 5901 East 7th Street, Long Beach, CA 92658, USA, martin.jadus@med.va.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 672 EP - 683 VL - 22 IS - 5 SN - 1084-9785, 1084-9785 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Interleukin 4 KW - Major histocompatibility complex KW - Cell culture KW - Tumor cells KW - Dendritic cells KW - Glioma cells KW - Monocytes KW - Lymphoma KW - FADD protein KW - Granulocyte-macrophage colony-stimulating factor KW - Colon cancer KW - Tumors KW - Cytotoxicity KW - Radioisotopes KW - Pharmaceuticals KW - Nitric oxide KW - W 30940:Products KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20027691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Biotherapy+and+Radiopharmaceuticals&rft.atitle=Human+Allogeneic+and+Murine+Xenogeneic+Dendritic+Cells+Are+Cytotoxic+to+Human+Tumor+Cells+via+Two+Distinct+Pathways&rft.au=Schiltz%2C+P+M%3BLee%2C+G+J%3BZhang%2C+J+G%3BHoa%2C+N%3BWepsic%2C+H+T%3BDillman%2C+RO%3BJadus%2C+M+R&rft.aulast=Schiltz&rft.aufirst=P&rft.date=2007-10-01&rft.volume=22&rft.issue=5&rft.spage=672&rft.isbn=&rft.btitle=&rft.title=Cancer+Biotherapy+and+Radiopharmaceuticals&rft.issn=10849785&rft_id=info:doi/10.1089%2Fcbr.2007.356 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Dendritic cells; Tumor cells; Cell culture; Nitric oxide; Cytotoxicity; Monocytes; FADD protein; Interleukin 4; Glioma cells; Granulocyte-macrophage colony-stimulating factor; Lymphoma; Tumors; Major histocompatibility complex; Colon cancer; Radioisotopes; Pharmaceuticals DO - http://dx.doi.org/10.1089/cbr.2007.356 ER - TY - JOUR T1 - Cigarette smoke induces demethylation of prometastatic oncogene synuclein-[gamma] in lung cancer cells by downregulation of DNMT3B AN - 19733118; 7565720 AB - The prometastatic oncogene synuclein-[gamma] (SNCG) is not expressed in normal lung tissues, but it is highly expressed in lung tumors. Here, we show that cigarette smoke extract (CSE) has strong inducing effects on SNCG gene expression in A549 lung cancer cells through demethylation of SNCG CpG island. CSE treatment also augments the invasive capacity of A549 cells in an SNCG-dependent manner. To elucidate the mechanisms underlying the demethylating effects of CSE, we examined expression levels of DNA methyltransferases (DNMTs), 1, 3A and 3B in CSE-treated cells. We show that the mRNA expression of DNMT3B is specifically downregulated by CSE with a kinetics concurrent to SNCG reexpression. Utilizing siRNA to knockdown DNMT3B expression, we show that inhibition of DNMT3B directly increases SNCG mRNA expression. We further show that exogenous overexpression of DNMT3B in an SNCG-positive lung cancer cell line H292 suppresses SNCG mRNA and protein expression and induces de novo methylation of SNCG CpG island, whereas overexpression of DNMT1 or DNMT3A has no effects. Taken together, these new findings demonstrate that tobacco exposure induces the abnormal expression of SNCG in lung cancer cells through downregulation of DNMT3B. This work sheds light on the molecular understanding of demethylation of this oncogene during cancer progression. JF - Oncogene AU - Liu, H AU - Zhou, Y AU - Boggs, S E AU - Belinsky, S A AU - Liu, J AD - Department of Veterans Affairs, Palo Alto Health Care System, Palo Alto, CA, USA, Jingwen.Liu@med.va.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 5900 EP - 5910 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 26 IS - 40 SN - 0950-9232, 0950-9232 KW - Genetics Abstracts; Toxicology Abstracts; Oncogenes & Growth Factors Abstracts KW - synuclein-[gamma] KW - DNA methylation KW - DNMT3B KW - cigarette smoke extract KW - lung cancer KW - cell invasion KW - Invasiveness KW - DNMT1 protein KW - Cigarette smoke KW - CpG islands KW - Tumors KW - Gene expression KW - Tumor cell lines KW - Demethylation KW - Oncogenes KW - siRNA KW - Kinetics KW - Tobacco KW - DNA methyltransferase KW - Methylation KW - Lung cancer KW - X 24380:Social Poisons & Drug Abuse KW - G 07730:Development & Cell Cycle KW - B 26680:Metastasis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19733118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Cigarette+smoke+induces+demethylation+of+prometastatic+oncogene+synuclein-%5Bgamma%5D+in+lung+cancer+cells+by+downregulation+of+DNMT3B&rft.au=Liu%2C+H%3BZhou%2C+Y%3BBoggs%2C+S+E%3BBelinsky%2C+S+A%3BLiu%2C+J&rft.aulast=Liu&rft.aufirst=H&rft.date=2007-10-01&rft.volume=26&rft.issue=40&rft.spage=5900&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1210400 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Invasiveness; DNMT1 protein; Cigarette smoke; Tumors; CpG islands; Gene expression; Demethylation; Tumor cell lines; Oncogenes; siRNA; Kinetics; DNA methylation; Tobacco; DNA methyltransferase; Methylation; Lung cancer DO - http://dx.doi.org/10.1038/sj.onc.1210400 ER - TY - JOUR T1 - Selective Use of Intranasal Mupirocin and Chlorhexidine Bathing and the Incidence of Methicillin-Resistant Staphylococcus aureus Colonization and Infection Among Intensive Care Unit Patients AN - 19612124; 8584877 AB - Objective. To determine whether the use of chlorhexidine bathing and intranasal mupirocin therapy among patients colonized with methicillin- resistant Staphylococcus aureus (MRSA) would decrease the incidence of MRSA colonization and infection among intensive care unit (ICU) patients. Methods. After a 9-month baseline period (January 13, 2003, through October 12, 2003) during which all incident cases of MRSA colonization or infection were identified through the use of active-surveillance cultures in a combined medical-coronary ICU, all patients colonized with MRSA were treated with intranasal mupirocin and underwent daily chlorhexidine bathing. Results. After the intervention, incident cases of MRSA colonization or infection decreased 52% (incidence density, 8.45 vs 4.05 cases per 1,000 patient-days; [image]). All MRSA isolates remained susceptible to chlorhexidine; the overall rate of mupirocin resistance was low (4.4%) among isolates identified by surveillance cultures and did not increase during the intervention period. Conclusions. We conclude that the selective use of intranasal mupirocin and daily chlorhexidine bathing for patients colonized with MRSA reduced the incidence of MRSA colonization and infection and contributed to reductions identified by active-surveillance cultures. This finding suggests that additional strategies to reduce the incidence of MRSA infection and colonization-beyond expanded surveillance-may be needed. JF - Infection Control and Hospital Epidemiology AU - Ridenour, Glenn AU - Lampen, Russell AU - Federspiel, Jeff AU - Kritchevsky, Steve AU - Wong, Edward AU - Climo, Michael AD - Division of Infectious Diseases, Hunter Holmes McGuire Veterans Affairs Medical Center, and the Virginia Commonwealth University Medical Center, Richmond, Virginia, michael.climo@med.va.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1155 EP - 1161 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 28 IS - 10 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - Colonization KW - Chlorhexidine KW - Mupirocin KW - Intensive care units KW - Drug resistance KW - Staphylococcus aureus KW - Infection KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19612124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Selective+Use+of+Intranasal+Mupirocin+and+Chlorhexidine+Bathing+and+the+Incidence+of+Methicillin-Resistant+Staphylococcus+aureus+Colonization+and+Infection+Among+Intensive+Care+Unit+Patients&rft.au=Ridenour%2C+Glenn%3BLampen%2C+Russell%3BFederspiel%2C+Jeff%3BKritchevsky%2C+Steve%3BWong%2C+Edward%3BClimo%2C+Michael&rft.aulast=Ridenour&rft.aufirst=Glenn&rft.date=2007-10-01&rft.volume=28&rft.issue=10&rft.spage=1155&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F520102 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Colonization; Mupirocin; Chlorhexidine; Intensive care units; Drug resistance; Infection; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1086/520102 ER - TY - JOUR T1 - Shared medical appointments based on the chronic care model: a quality improvement project to address the challenges of patients with diabetes with high cardiovascular risk AN - 19552358; 8747943 AB - Objective: The epidemic proportions and management complexity of diabetes have prompted efforts to improve clinic throughput and efficiency. One method of system redesign based on the chronic care model is the Shared Medical Appointment (SMA) in which groups of patients (8-20) are seen by a multi-disciplinary team in a 1-2 h appointment. Evaluation of the impact of SMAs on quality of care has been limited. The purpose of this quality improvement project was to improve intermediate outcome measures for diabetes (A1c, SBP, LDL-cholesterol) focusing on those patients at highest cardiovascular risk. Setting: Primary care clinic at a tertiary care academic medical center. Subjects: Patients with diabetes with one or more of the following: A1c >9%, SBP blood pressure >160 mm Hg and LDL-c >130 mg/dl were targeted for potential participation; other patients were referred by their primary care providers. Patients participated in at least one SMA from 4/05 to 9/05. Study design: Quasi-experimental with concurrent, but non-randomised controls (patients who participated in SMAs from 5/06 through 8/06; a retrospective period of observation prior to their SMA participation was used). Intervention: SMA system redesign Analytical methods: Paired and independent t tests, X super(2) tests and Fisher Exact tests. Results: Each group had up to 8 patients. Patients participated in 1-7 visits. At the initial visit, 83.3% had A1c levels >9%, 30.6% had LDL-cholesterol levels >130 mg/dl, and 34.1% had SBP greater than or equal to 160 mm Hg. Levels of A1c, LDL-c and SBP all fell significantly postintervention with a mean (95% CI) decrease of A1c 1.4 (0.8, 2.1) (p<0.001), LDL-c 14.8 (2.3, 27.4) (p = 0.022) and SBP 16.0 (9.7, 22.3) (p<0.001). There were no significant differences at baseline between control and intervention groups in terms of age, baseline intermediate outcomes, or medication use. The reductions in A1c in % and SBP were greater in the intervention group relative to the control group: 1.44 vs -0.30 (p = 0.002) for A1c and 14.83 vs 2.54 mm Hg (p = 0.04) for SBP. LDL-c reduction was also greater in the intervention group, 16.0 vs 5.37 mg/dl, but the difference was not statistically significant (p = 0.29). Conclusions: We were able to initiate a programme of group visits in which participants achieved benefits in terms of cardiovascular risk reduction. Some barriers needed to be addressed, and the operations of SMAs evolved over time. Shared medical appointments for diabetes constitute a practical system redesign that may help to improve quality of care. JF - Quality & Safety in Health Care AU - Kirsh, S AU - Watts, S AU - Pascuzzi, K AU - O'Day, ME AU - Davidson, D AU - Strauss, G AU - Kern, E O AU - Aron, D C AD - Medical Service (111W), Louis Stokes Cleveland VA Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA, susan.kirsh@va.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 387 EP - 399 VL - 16 IS - 5 SN - 1475-3898, 1475-3898 KW - Health & Safety Science Abstracts KW - Age KW - risk reduction KW - diabetes mellitus KW - safety engineering KW - Health care KW - intervention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19552358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quality+%26+Safety+in+Health+Care&rft.atitle=Shared+medical+appointments+based+on+the+chronic+care+model%3A+a+quality+improvement+project+to+address+the+challenges+of+patients+with+diabetes+with+high+cardiovascular+risk&rft.au=Kirsh%2C+S%3BWatts%2C+S%3BPascuzzi%2C+K%3BO%27Day%2C+ME%3BDavidson%2C+D%3BStrauss%2C+G%3BKern%2C+E+O%3BAron%2C+D+C&rft.aulast=Kirsh&rft.aufirst=S&rft.date=2007-10-01&rft.volume=16&rft.issue=5&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Quality+%26+Safety+in+Health+Care&rft.issn=14753898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - diabetes mellitus; intervention; risk reduction; safety engineering; Health care; Age ER - TY - JOUR T1 - The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal. AN - 68206878; 17610870 AB - Corticotropin-releasing factor (CRF) regulates the hypothalamic-pituitary-adrenal axis, coordinates the mammalian stress response, and acting primarily via the CRF(1) receptor, has been strongly implicated in the pathophysiology of depression and anxiety. Furthermore, the behavioral and autonomic activation that occurs following withdrawal in drug dependent animals resembles the mammalian stress response. Concordant with this view is evidence of enhanced CRF transcription, release and activity following withdrawal from several drugs of abuse. Conversely, CRF receptor antagonists have been demonstrated to reduce the severity of many drug withdrawal symptoms, implicating a specific role for activation of CRF neurons in mediating the anxiogenic and stress-like reactions observed during withdrawal. To extend these findings, we investigated whether pretreatment with a selective CRF(1) receptor antagonist, R121919, is capable of similarly decreasing the autonomic, behavioral and neuroendocrine activation observed following precipitation of morphine withdrawal in dependent rats. The results indicate that pretreatment with R121919 attenuates the global severity of the precipitated morphine withdrawal syndrome as measured by the Gellert-Holtzman scale. In addition, rats pretreated with R121919 prior to precipitation of morphine withdrawal demonstrated decreased hypothalamic-pituitary-adrenal axis activation, as measured by plasma ACTH concentrations, and decreased early expression of the CRF gene in the paraventricular nucleus of the hypothalamus, as measured by CRF heteronuclear RNA. These findings suggest that activation of CRF neuronal systems via the CRF(1) receptor may be one element of the neurobiological mechanisms activated during drug withdrawal and that CRF(1) receptor antagonists may have a potential therapeutic role in the treatment of human drug withdrawal syndromes. JF - European journal of pharmacology AU - Skelton, Kelly H AU - Oren, Dana AU - Gutman, David A AU - Easterling, Keith AU - Holtzman, Stephen G AU - Nemeroff, Charles B AU - Owens, Michael J AD - Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322 , USA. kelly.skelton@va.gov Y1 - 2007/09/24/ PY - 2007 DA - 2007 Sep 24 SP - 17 EP - 24 VL - 571 IS - 1 SN - 0014-2999, 0014-2999 KW - Analgesics, Opioid KW - 0 KW - CRF receptor type 1 KW - Pyrimidines KW - R 121919 KW - RNA, Messenger KW - Receptors, Corticotropin-Releasing Hormone KW - Morphine KW - 76I7G6D29C KW - Index Medicus KW - Severity of Illness Index KW - Animals KW - Hypothalamo-Hypophyseal System -- drug effects KW - RNA, Messenger -- genetics KW - Pituitary-Adrenal System -- physiology KW - Rats KW - Hypothalamo-Hypophyseal System -- physiology KW - Behavior, Animal -- drug effects KW - Paraventricular Hypothalamic Nucleus -- metabolism KW - Rats, Sprague-Dawley KW - In Situ Hybridization KW - RNA, Messenger -- metabolism KW - Analgesics, Opioid -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Pituitary-Adrenal System -- drug effects KW - Male KW - Substance Withdrawal Syndrome -- pathology KW - Substance Withdrawal Syndrome -- physiopathology KW - Receptors, Corticotropin-Releasing Hormone -- physiology KW - Substance Withdrawal Syndrome -- prevention & control KW - Pyrimidines -- pharmacology KW - Receptors, Corticotropin-Releasing Hormone -- antagonists & inhibitors KW - Receptors, Corticotropin-Releasing Hormone -- genetics KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68206878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=The+CRF1+receptor+antagonist%2C+R121919%2C+attenuates+the+severity+of+precipitated+morphine+withdrawal.&rft.au=Skelton%2C+Kelly+H%3BOren%2C+Dana%3BGutman%2C+David+A%3BEasterling%2C+Keith%3BHoltzman%2C+Stephen+G%3BNemeroff%2C+Charles+B%3BOwens%2C+Michael+J&rft.aulast=Skelton&rft.aufirst=Kelly&rft.date=2007-09-24&rft.volume=571&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-06 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Training Needs for the Treatment of Combat-Related Posttraumatic Stress Disorder: A Survey of Department of Defense Clinicians AN - 759314166; 13642379 AB - In 2004, the United States Departments of Veterans Affairs (VA) and Defense jointly published clinical-practice guidelines for posttraumatic stress disorder (CPG-PTSD). These identified 4 psychotherapies for PTSD: cognitive therapy, eye-movement desensitization and reprocessing, exposure therapy, and stress inoculation therapy. One hundred thirty-seven mental-health professionals employed by the military or the VA were surveyed as to whether they used any of these psychotherapies and the extent of their training in them. Ninety percent of respondents reported not using any of the 4 psychotherapies. Of those who did, most had received their training before their affiliation with the military, and only a handful had training in the specific use of psychotherapy with PTSD. The lack of available, CPG-identified, effective psychotherapies is discussed as a barrier to treatment, as are possible reasons the psychotherapies are not used. A brief description of a training program is provided along with suggestions for the future. JF - Traumatology AU - Russell, Mark AU - Silver, Steven M AD - United States Naval Hospital, Bremerton, Washington, Steven.Silver2@va.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 4 EP - 10 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 13 IS - 3 SN - 1534-7656, 1534-7656 KW - Health & Safety Science Abstracts KW - posttraumatic stress disorder KW - Training KW - Psychology KW - Stress KW - USA KW - guidelines KW - Military KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759314166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traumatology&rft.atitle=Training+Needs+for+the+Treatment+of+Combat-Related+Posttraumatic+Stress+Disorder%3A+A+Survey+of+Department+of+Defense+Clinicians&rft.au=Russell%2C+Mark%3BSilver%2C+Steven+M&rft.aulast=Russell&rft.aufirst=Mark&rft.date=2007-09-01&rft.volume=13&rft.issue=3&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F1534765607305440 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - posttraumatic stress disorder; guidelines; Psychology; Training; Stress; Military; USA DO - http://dx.doi.org/10.1177/1534765607305440 ER - TY - JOUR T1 - The use of cognitive enhancers in behavioral disturbances of Alzheimer's disease. AN - 70059060; 18198970 AB - To review the literature for double-blind, placebo-controlled trials that examined the efficacy of cognitive enhancers in the psychopathology of Alzheimer's disease. Literature searches were conducted using MEDLINE and EMBASE databases and clinicaltrials.gov. Overall, 55 articles were reviewed for inclusion. Several open-label studies and case reports were found on this topic, but only those involving both tacrine and use of the Neuropsychiatric Inventory were included. Regarding other drugs, only double-blind, placebo-controlled trials were selected for inclusion. Limited data suggest that the anticholinesterase inhibitors and memantine offer an alternative or adjunct to the antipsychotics for the treatment of moderate-to-severe behaviors. The author reviewed the literature for pharmacological management of behavioral and psychological symptoms of dementia (BPSD) using these cognitive enhancers. The majority of patients with Alzheimer's disease will experience behavioral disturbances during the course of their disease. Atypical antipsychotics are used routinely in these situations to treat the psychotic features and agitation. However, atypicals now carry a "black box" warning issued by the Food and Drug Administration on the basis of evidence that their use in geriatric patients with dementia-related psychosis may put patients at increased risk of mortality as a result of cardiovascular or infectious events. An alternative to the atypicals may be the acetylcholinesterase inhibitors and memantine, which have been shown to stabilize cognitive as well as behavioral issues in patients, utilizing the "gold standard" for behavior, the Neuropsychiatric Inventory. Efficacy varies among agents, with the greatest positive effects seen with donepezil, which also has the greatest number of studies. Drug benefits were harder to demonstrate for mild-to-moderate BPSD compared with moderate-to-severe symptoms. JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists AU - Miller, Lisa J AD - Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA. lisaj.miller@med.va.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 754 EP - 762 VL - 22 IS - 9 SN - 0888-5109, 0888-5109 KW - Antipsychotic Agents KW - 0 KW - Cholinesterase Inhibitors KW - Dopamine Agents KW - Nootropic Agents KW - Index Medicus KW - Psychomotor Agitation -- drug therapy KW - Humans KW - Cognition Disorders -- drug therapy KW - Psychotic Disorders -- drug therapy KW - Dopamine Agents -- therapeutic use KW - Mental Disorders -- drug therapy KW - Cholinesterase Inhibitors -- therapeutic use KW - Antipsychotic Agents -- therapeutic use KW - Alzheimer Disease -- psychology KW - Nootropic Agents -- therapeutic use KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70059060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.atitle=The+use+of+cognitive+enhancers+in+behavioral+disturbances+of+Alzheimer%27s+disease.&rft.au=Miller%2C+Lisa+J&rft.aulast=Miller&rft.aufirst=Lisa&rft.date=2007-09-01&rft.volume=22&rft.issue=9&rft.spage=754&rft.isbn=&rft.btitle=&rft.title=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.issn=08885109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-07 N1 - Date created - 2008-01-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Consult Pharm. 2008 May;23(5):357-8 [18556821] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Abuse of olanzapine by substance abusers. AN - 69086630; 18159784 AB - Olanzapine has been used for over a decade for treatment of schizophrenia and bipolar disorder. The drug may have sedative properties for some patients, especially in large doses. The case reported here involves a 25-year-old male who abused olanzapine, both by itself and in combination with other drugs. Also described are the patient's reports of abuse of olanzapine by several of his acquaintances. The potential for abuse of olanzapine by substance abusers is discussed. JF - Journal of psychoactive drugs AU - Reeves, Roy R AD - Montgomery VA Medical Center, Jackson, MS 39216, USA. roy.reeves@med.va.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 297 EP - 299 VL - 39 IS - 3 SN - 0279-1072, 0279-1072 KW - Antipsychotic Agents KW - 0 KW - Benzodiazepines KW - 12794-10-4 KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Antipsychotic Agents -- administration & dosage KW - Antipsychotic Agents -- pharmacology KW - Substance-Related Disorders -- etiology KW - Benzodiazepines -- administration & dosage KW - Benzodiazepines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69086630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=Abuse+of+olanzapine+by+substance+abusers.&rft.au=Reeves%2C+Roy+R&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2007-09-01&rft.volume=39&rft.issue=3&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2007-12-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Contracting, prompting, and reinforcing substance use disorder continuing care: a randomized clinical trial. AN - 68287307; 17874889 AB - Although continuing care is strongly related to positive treatment outcomes for substance use disorder (SUD), participation rates are low and few effective interventions are available. In a randomized clinical trial with 150 participants (97% men), 75 graduates of a residential Veterans Affairs Medical Center SUD program who received an aftercare contract, attendance prompts, and reinforcers (CPR) were compared to 75 graduates who received standard treatment (STX). Among CPR participants, 55% completed at least 3 months of aftercare, compared to 36% in STX. Similarly, CPR participants remained in treatment longer than those in STX (5.5 vs. 4.4 months). Additionally, CPR participants were more likely to be abstinent compared to STX (57% vs. 37%) after 1 year. The CPR intervention offers a practical means to improve adherence among individuals in SUD treatment. JF - Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors AU - Lash, Steven J AU - Stephens, Robert S AU - Burden, Jennifer L AU - Grambow, Steven C AU - DeMarce, Josephine M AU - Jones, Mark E AU - Lozano, Brian E AU - Jeffreys, Amy S AU - Fearer, Stephanie A AU - Horner, Ronnie D AD - Mental Health Service Line, Salem Veterans Affairs Medical Center, Salem, VA, USA. steven.lash@med.va.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 387 EP - 397 VL - 21 IS - 3 SN - 0893-164X, 0893-164X KW - Index Medicus KW - Residential Treatment KW - Humans KW - Adult KW - Temperance -- psychology KW - Middle Aged KW - Follow-Up Studies KW - Alcoholics Anonymous KW - Longitudinal Studies KW - Male KW - Female KW - Comorbidity KW - Alcoholism -- rehabilitation KW - Reinforcement, Social KW - Motivation KW - Behavior Therapy KW - Veterans -- psychology KW - Social Support KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Aftercare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68287307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+addictive+behaviors+%3A+journal+of+the+Society+of+Psychologists+in+Addictive+Behaviors&rft.atitle=Contracting%2C+prompting%2C+and+reinforcing+substance+use+disorder+continuing+care%3A+a+randomized+clinical+trial.&rft.au=Tangney%2C+June+Price%3BStuewig%2C+Jeffrey%3BMashek%2C+Debra+J.&rft.aulast=Tangney&rft.aufirst=June&rft.date=2007-01-01&rft.volume=&rft.issue=&rft.spage=21&rft.isbn=1-59385-486-2&rft.btitle=The+self-conscious+emotions%3A+Theory+and+research&rft.title=The+self-conscious+emotions%3A+Theory+and+research&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-13 N1 - Date created - 2007-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Implantable cardioverter defibrillator therapy and the need for concomitant antiarrhythmic drugs. AN - 68284761; 17875944 AB - Implantable cardioverter defibrillators (ICDs) are increasingly used for the prevention of sudden cardiac death in patients with life-threatening ventricular arrhythmias (VAs); however, there is a potential for severe and debilitating anxiety caused by symptoms associated with ICD therapy and anticipation of shocks. Anxiety is a psycho-logic stressor, including physiologic components that may lead to adrenergic excitation triggering new arrhythmias and ICD therapies. This often requires concomitant antiarrhythmic medication to reduce the frequency of shocks and symptomatic arrhythmias treated by anti-tachycardia pacing. Although published studies have documented the efficacy of currently available antiarrhythmics, they have limitations in patients with heart failure, may affect the defibrillation threshold, and/or have been associated with major side-effects. In conclusion, for the patient with an ICD experiencing symptomatic ventricular tachycardia (VTs) episodes or ICD shocks, there is a need for pharmacologic therapy to reduce the incidence of such events without affecting the performance of the ICD or causing major side-effects. JF - Journal of cardiovascular pharmacology and therapeutics AU - Singh, Steven AU - Murawski, Matthew M AD - Veterans Affairs Medical Center, Washington, DC 20422, USA. steve.singh@med.va.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 175 EP - 180 VL - 12 IS - 3 SN - 1074-2484, 1074-2484 KW - Anti-Arrhythmia Agents KW - 0 KW - Index Medicus KW - Electric Countershock KW - Anxiety KW - Combined Modality Therapy KW - Humans KW - Quality of Life KW - Death, Sudden, Cardiac -- prevention & control KW - Defibrillators, Implantable -- adverse effects KW - Ventricular Fibrillation -- therapy KW - Tachycardia, Ventricular -- therapy KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68284761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.atitle=Implantable+cardioverter+defibrillator+therapy+and+the+need+for+concomitant+antiarrhythmic+drugs.&rft.au=Singh%2C+Steven%3BMurawski%2C+Matthew+M&rft.aulast=Singh&rft.aufirst=Steven&rft.date=2007-09-01&rft.volume=12&rft.issue=3&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.issn=10742484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-25 N1 - Date created - 2007-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Proton pump inhibitor use and risk of colorectal cancer: a population-based, case-control study. AN - 68269905; 17678921 AB - Use of proton pump inhibitors (PPIs) has been associated with elevated levels of serum gastrin. Because hypergastrinemia increases colorectal mucosa proliferation and has been associated with risk of colorectal cancer (CRC) in human beings, we conducted a large population-based study in Denmark to assess whether PPI use is associated with CRC risk. We conducted the study in North Jutland County, Denmark. From the County Hospital Discharge Registry we identified incident cases of CRC during the period 1989-2005. Using risk set sampling we selected approximately 10 controls from the Danish Civil Registration System, with matching for sex and birth year. PPI use was ascertained in the Prescription Database of North Jutland (and so recorded before CRC diagnosis) and analyzed with conditional logistic regression adjusted for multiple covariates. We identified 5589 cases of CRC which were compared with 55,890 controls. In a comparison of ever to never or rare users (7 years; adjusted OR = 1.09; 95% CI, 0.58-2.06). The use of PPIs in clinical practice does not measurably increase the risk of CRC. JF - Gastroenterology AU - Robertson, Douglas J AU - Larsson, Heidi AU - Friis, Søren AU - Pedersen, Lars AU - Baron, John A AU - Sørensen, Henrik T AD - VA Medical Center, White River Junction, VT 05009, USA. Douglas.robertson@med.va.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 755 EP - 760 VL - 133 IS - 3 SN - 0016-5085, 0016-5085 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Gastrins KW - Histamine H2 Antagonists KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Hypoglycemic Agents KW - Proton Pump Inhibitors KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Gastrins -- blood KW - Aged KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- therapeutic use KW - Cell Proliferation KW - Hypoglycemic Agents -- therapeutic use KW - Histamine H2 Antagonists -- adverse effects KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Logistic Models KW - Risk Factors KW - Hypoglycemic Agents -- adverse effects KW - Case-Control Studies KW - Denmark -- epidemiology KW - Intestinal Mucosa -- pathology KW - Time Factors KW - Male KW - Female KW - Histamine H2 Antagonists -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Aspirin -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Aspirin -- therapeutic use KW - Colorectal Neoplasms -- epidemiology KW - Colorectal Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68269905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Proton+pump+inhibitor+use+and+risk+of+colorectal+cancer%3A+a+population-based%2C+case-control+study.&rft.au=Robertson%2C+Douglas+J%3BLarsson%2C+Heidi%3BFriis%2C+S%C3%B8ren%3BPedersen%2C+Lars%3BBaron%2C+John+A%3BS%C3%B8rensen%2C+Henrik+T&rft.aulast=Robertson&rft.aufirst=Douglas&rft.date=2007-09-01&rft.volume=133&rft.issue=3&rft.spage=755&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-23 N1 - Date created - 2007-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential expression of stress-inducible proteins in chronic hepatic iron overload. AN - 68249152; 17590401 AB - Oxidative stress can trigger a cellular stress response characterized by induction of antioxidants, acute phase reactants (APRs) and heat shock proteins (HSPs), which are presumed to play a role in limiting tissue damage. In rodents, hepatic iron overload causes oxidative stress that results in upregulation of antioxidant defenses with minimal progressive liver injury. The aim of this study was to determine whether iron overload modulates expression of other stress-responsive proteins such as APRs and HSPs that may confer protection against iron-induced damage in rodent liver. Male rats received repeated injections of iron dextran or dextran alone over a 6-month period. Hepatic transcript levels for a panel of APRs and HSPs were quantitated by real-time PCR and protein expression was evaluated by Western blot and immunohistochemistry. Hepatic iron concentrations were increased >50-fold in the iron-loaded rats compared to controls. Iron loading resulted in striking increases in mRNAs for Hsp32 (heme oxygenase-1; 12-fold increase vs. controls) and metallothionein-1 and -2 (both increased approximately 6-fold). Transcripts for alpha1-acid glycoprotein, the major rat APR, were increased approximately 3-fold, while expression of other classical APRs was unaltered. Surprisingly, although mRNA levels for the HSPs were not altered by iron, the abundance of Hsp25, Hsp70 and Hsp90 proteins was uniformly reduced in the iron-loaded livers, as were levels of NAD(P)H:quinone oxidoreductase 1, an Hsp70 client protein. Chronic iron administration elicits a unique pattern of stress protein expression. These alterations may modulate hepatic responses to iron overload, as well as other injury processes. JF - Toxicology and applied pharmacology AU - Brown, Kyle E AU - Broadhurst, Kimberly A AU - Mathahs, M Meleah AU - Weydert, Jamie AD - Iowa City Veterans Administration Medical Center, Division of Gastroenterology-Hepatology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City 52242, USA. kyle-brown@uiowa.edu Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 180 EP - 186 VL - 223 IS - 2 SN - 0041-008X, 0041-008X KW - Acute-Phase Proteins KW - 0 KW - Blood Proteins KW - Glycoproteins KW - Heat-Shock Proteins KW - Iron-Regulatory Proteins KW - Orm1 protein, rat KW - Orosomucoid KW - Iron-Dextran Complex KW - 9004-66-4 KW - Apoferritins KW - 9013-31-4 KW - Metallothionein KW - 9038-94-2 KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - NAD(P)H Dehydrogenase (Quinone) KW - EC 1.6.5.2 KW - NQO1 protein, rat KW - Index Medicus KW - Animals KW - Apoferritins -- genetics KW - Hepatocytes -- drug effects KW - Metallothionein -- genetics KW - Liver -- metabolism KW - Kupffer Cells -- drug effects KW - Iron-Regulatory Proteins -- metabolism KW - NAD(P)H Dehydrogenase (Quinone) -- metabolism KW - Rats KW - NAD(P)H Dehydrogenase (Quinone) -- genetics KW - Liver -- drug effects KW - Iron-Dextran Complex -- toxicity KW - Iron-Dextran Complex -- administration & dosage KW - Gene Expression Regulation -- drug effects KW - Male KW - Injections, Intraperitoneal KW - Dose-Response Relationship, Drug KW - Heme Oxygenase-1 -- genetics KW - Apoferritins -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - Glycoproteins -- genetics KW - Blood Proteins -- genetics KW - Rats, Sprague-Dawley KW - Blotting, Western KW - Glycoproteins -- metabolism KW - Heme Oxygenase-1 -- metabolism KW - Kupffer Cells -- metabolism KW - Chronic Disease KW - Blood Proteins -- metabolism KW - Immunohistochemistry KW - Metallothionein -- metabolism KW - Hepatocytes -- metabolism KW - Iron-Regulatory Proteins -- genetics KW - Heat-Shock Proteins -- metabolism KW - Gene Expression Profiling KW - Acute-Phase Proteins -- genetics KW - Iron Overload -- physiopathology KW - Iron Overload -- chemically induced KW - Acute-Phase Proteins -- metabolism KW - Heat-Shock Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68249152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Differential+expression+of+stress-inducible+proteins+in+chronic+hepatic+iron+overload.&rft.au=Brown%2C+Kyle+E%3BBroadhurst%2C+Kimberly+A%3BMathahs%2C+M+Meleah%3BWeydert%2C+Jamie&rft.aulast=Brown&rft.aufirst=Kyle&rft.date=2007-09-01&rft.volume=223&rft.issue=2&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-30 N1 - Date created - 2007-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of a standard shade guide for color change after disinfection. AN - 68248745; 17823685 AB - To determine if surface disinfectants cause a change in the shade perception of a standard Classic Vitapan shade guide. Consistency in shade selection for dental restorations involves many factors, and one of the most important is the shade tabs used in the selection process. Ten shade tabs each of shades B2, D2, C1, and A3.5 were selected from the Classic Vitapan shade guide (Vident). All tabs were measured with the EasyShade shade device (Vident) at baseline. Three tabs of each shade were set aside as controls. The other 7 tabs of each shade were treated with the surface disinfectant Cavicide (Metrex Research) for 480 cycles to simulate a year's usage. After each 480 cycles, all the tabs were again measured with the EasyShade. This process was repeated to simulate 2 and 3 years of use. The data were analyzed to calculate the delta E 2000 for any change. A statistically significant increase was observed in the value (L*) and chroma (C*) after 2 and 3 years of simulated treatments. These changes were not perceptible to the clinician. The authors suggest that 1 standard shade guide be set aside to compare against those in clinical use to determine when they should be replaced. JF - Quintessence international (Berlin, Germany : 1985) AU - Pohjola, Randall M AU - Hackman, Steven T AU - Browning, William D AD - Veterans Administration Hospital, Augusta, GA 30904, USA. randall.pohjola@va.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 671 EP - 676 VL - 38 IS - 8 KW - Chlorophenols KW - 0 KW - Dental Disinfectants KW - cavicide KW - Dentistry KW - United States KW - United States Occupational Safety and Health Administration KW - Time Factors KW - Spectrophotometry -- methods KW - Dental Disinfectants -- adverse effects KW - Color -- standards KW - Chlorophenols -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68248745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quintessence+international+%28Berlin%2C+Germany+%3A+1985%29&rft.atitle=Evaluation+of+a+standard+shade+guide+for+color+change+after+disinfection.&rft.au=Pohjola%2C+Randall+M%3BHackman%2C+Steven+T%3BBrowning%2C+William+D&rft.aulast=Pohjola&rft.aufirst=Randall&rft.date=2007-09-01&rft.volume=38&rft.issue=8&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Quintessence+international+%28Berlin%2C+Germany+%3A+1985%29&rft.issn=1936-7163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Etomidate and unpredicted seizures during electroconvulsive therapy. AN - 68243647; 17804993 AB - Electroconvulsive therapy has been a novel treatment for about half a century, effective for severe psychiatric conditions. Over the years, the treatment has been refined with the addition of anesthesia. Different inducing agents have been used in clinical practice over the last few decades including propofol, methohexital, and etomidate. Previous literature rarely mentions seizures soon after induction with etomidate and typically only in anesthesia literature. We describe 2 cases with different demographics, diagnosis, and treatment that had seizures with the use of etomidate as an inducing agent. JF - The journal of ECT AU - Griffeth, Benjamin T AU - Mehra, Abhishek AD - ER Psychiatry, Salem Veterans Affairs Medical Center, Salem, VA 24153, USA. benjamin.griffeth@va.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 177 EP - 178 VL - 23 IS - 3 SN - 1095-0680, 1095-0680 KW - Anesthetics, Intravenous KW - 0 KW - Etomidate KW - Z22628B598 KW - Index Medicus KW - Risk Factors KW - Humans KW - European Continental Ancestry Group KW - Anesthetics, Intravenous -- pharmacology KW - Adult KW - African Americans KW - Middle Aged KW - Male KW - Female KW - Seizures -- chemically induced KW - Seizures -- etiology KW - Electroconvulsive Therapy KW - Etomidate -- adverse effects KW - Etomidate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68243647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2007-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=1-59385-486-2&rft.btitle=The+self-conscious+emotions%3A+Theory+and+research&rft.title=The+self-conscious+emotions%3A+Theory+and+research&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-07 N1 - Date created - 2007-09-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Using neurobiology to reframe the need for alcohol policy interventions. AN - 68165743; 17697272 JF - Addiction (Abingdon, England) AU - Trafton, Jodie A AD - VA Program Evaluation and Resource Center, 795 Willow Road (152-MPD), Menlo Park, CA 94025, USA. jodie.trafton@va.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1351 EP - 2; discussion 1354-5 VL - 102 IS - 9 SN - 0965-2140, 0965-2140 KW - Index Medicus KW - Humans KW - Health Promotion KW - Alcohol Drinking -- adverse effects KW - Neurobiology -- methods KW - Health Behavior KW - Alcohol-Related Disorders -- prevention & control KW - Alcohol Drinking -- prevention & control KW - Marketing -- standards KW - Alcohol Drinking -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68165743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Using+neurobiology+to+reframe+the+need+for+alcohol+policy+interventions.&rft.au=Trafton%2C+Jodie+A&rft.aulast=Trafton&rft.aufirst=Jodie&rft.date=2007-09-01&rft.volume=102&rft.issue=9&rft.spage=1351&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-11 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intragastric nitroglycerin at a vasodilatory dose attenuates acidified aspirin-induced gastric mucosal injury. AN - 68149922; 17420937 AB - Clinical studies reveal that aspirin intake to prevent myocardial and cerebral ischemia is associated with a significant increase in upper gastrointestinal hemorrhage requiring hospitalization and that nitroglycerin or long-acting nitrates significantly lower this risk. Nitroglycerin can increase gastric blood flow and slow gastric emptying. We hypothesized that both features contribute to its gastroprotective property. Fasted anesthetized rats (Study 1) and conscious mice (Studies 2 to 4) received intragastric nitroglycerin or vehicle. The effects of these two treatments on various parameters were assessed in Study 1, on blood pressure and gastric blood flow; Study 2, on acidified aspirin-induced gastric mucosal lesions; and Study 3, on the weight of gastric content. In Study 4, the effect of nitroglycerin, vehicle, or vehicle plus saline, on acidified aspirin-induced gastric mucosal lesion was assessed. Compared with vehicle, nitroglycerin decreased blood pressure and produced a mild but significant increase in gastric vascular conductance, blood flow, and volume of gastric content. The number and length of gastric mucosal lesions induced by acidified aspirin were significantly attenuated by intragastric nitroglycerin in a vasodilatory dose. Exogenous saline in a volume equivalent to the increase produced by nitroglycerin, however, did not attenuate the lesions. These experimental data are consistent with the clinical observation that nitrates lower the risk of aspirin-induced gastrointestinal complications. Confirmation of the efficacy of nitroglycerin and nitrates in preventing such aspirin-induced complications in controlled trials is worthy of consideration by clinical investigators. JF - Digestive diseases and sciences AU - Leung, Felix W AU - Chan, Chi Chung AD - Research and Medical Services, Sepulveda Ambulatory Care Center, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, Los Angeles, California 91343, USA. felix.leung@med.va.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 2229 EP - 2235 VL - 52 IS - 9 SN - 0163-2116, 0163-2116 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Vasodilator Agents KW - Nitroglycerin KW - G59M7S0WS3 KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Blood Flow Velocity -- drug effects KW - Aspirin -- toxicity KW - Treatment Outcome KW - Disease Models, Animal KW - Spectrophotometry KW - Mice KW - Anti-Inflammatory Agents, Non-Steroidal -- toxicity KW - Laser-Doppler Flowmetry KW - Male KW - Female KW - Vasodilator Agents -- administration & dosage KW - Gastric Mucosa -- blood supply KW - Vasoconstriction -- drug effects KW - Gastric Mucosa -- drug effects KW - Gastritis -- physiopathology KW - Gastritis -- drug therapy KW - Nitroglycerin -- administration & dosage KW - Gastritis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68149922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Intragastric+nitroglycerin+at+a+vasodilatory+dose+attenuates+acidified+aspirin-induced+gastric+mucosal+injury.&rft.au=Leung%2C+Felix+W%3BChan%2C+Chi+Chung&rft.aulast=Leung&rft.aufirst=Felix&rft.date=2007-09-01&rft.volume=52&rft.issue=9&rft.spage=2229&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-27 N1 - Date created - 2007-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transient Growth Factor Delivery Sustains Regenerated Axons after Spinal Cord Injury AN - 20805733; 7615403 AB - Growth factors influence the topography of axonal projections during nervous system development and facilitate axonal sprouting and regeneration after injury in the adult. However, in the absence of target reinnervation and reestablishment of synaptic activity, we hypothesized that continuing delivery of neurotrophins would be required to sustain regenerating axons for prolonged times points after neurotrophin-induced axon growth after spinal cord injury (SCI) in the adult. Using tetracycline-inducible expression of brain-derived neurotrophic factor by genetically modified fibroblasts, we were able to extensively and significantly turn growth factor expression "on" or "off" in vitro and in vivo within sites of SCI. Notably, we find that transient growth factor delivery is sufficient to sustain regenerated axons for prolonged time periods within spinal cord lesion sites. Immunohistochemical analysis demonstrated an absence of neuronal targets or synapses within transient growth factor expressing grafts but the persistent presence of Schwann cells. Thus, the adult CNS appears capable of sustaining axons that have extended after transient growth factor delivery, an effect potentially attributable to the persistence of Schwann cells in lesion/graft sites. JF - Journal of Neuroscience AU - Blesch, Armin AU - Tuszynski, Mark H AD - Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, and Veterans Administration Medical Center, San Diego, California 92165 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 10535 EP - 10545 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 27 IS - 39 SN - 0270-6474, 0270-6474 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Brain-derived neurotrophic factor KW - Central nervous system KW - Synapses KW - Axon sprouting KW - Neurotrophins KW - Axon guidance KW - Schwann cells KW - Spinal cord injury KW - Fibroblasts KW - Regeneration KW - Axonogenesis KW - Reinnervation KW - Growth factors KW - Topography KW - W 30925:Genetic Engineering KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20805733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Transient+Growth+Factor+Delivery+Sustains+Regenerated+Axons+after+Spinal+Cord+Injury&rft.au=Blesch%2C+Armin%3BTuszynski%2C+Mark+H&rft.aulast=Blesch&rft.aufirst=Armin&rft.date=2007-09-01&rft.volume=27&rft.issue=39&rft.spage=10535&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Brain-derived neurotrophic factor; Central nervous system; Synapses; Axon sprouting; Neurotrophins; Axon guidance; Schwann cells; Spinal cord injury; Fibroblasts; Regeneration; Axonogenesis; Growth factors; Reinnervation; Topography ER - TY - JOUR T1 - Peripheral Arterial Disease in a Multiethnic National Sample: the Role of Conventional Risk Factors and Allostatic Load AN - 20402574; 7827341 AB - Background: Limited data exist on the prevalence of peripheral arterial disease (PAD) among ethnically diverse populations. Our objectives were to assess the prevalence of PAD in a multiethnic national sample and examine risk factor control and allostatic load (a marker of dysregulation of the inflammatory, metabolic, and cardiovascular systems) by race/ethnicity among individuals with PAD. Methods: We analyzed data from the 1999-2002 National Health and Nutrition Examination Survey for individuals aged >40 with a measured ankle brachial index (N = 5,083). PAD was defined as an ankle brachial index 140/90 mm Hg, 28% were smokers, and 61% had a cholesterol value >200 mg/dL. Conclusions: Within this nationally representative sample, African Americans had the highest rates of PAD. Although conventional risk factor control, including control of hypertension and hyperlipidemia, were similar between racial groups, African Americans with PAD had higher allostatic load scores. Among all individuals with PAD, evidence showed suboptimal cardiovascular risk factor control. JF - Ethnicity & Disease AU - Nelson, Karin M AU - Reiber, Gayle AU - Kohler, Ted AU - Boyko, Edward J Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 669 EP - 675 PB - International Society on Hypertension in Blacks, 2045 Manchester St, NE Atlanta GA 30324 USA, [URL:http://www.ishib.org] VL - 17 IS - 4 SN - 1049-510X, 1049-510X KW - peripheral arterial disease KW - Risk Abstracts KW - Peripheral Vascular Disease KW - Race/Ethnicity KW - Cardiovascular system KW - hypertension KW - physical activity KW - Nutrition KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20402574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethnicity+%26+Disease&rft.atitle=Peripheral+Arterial+Disease+in+a+Multiethnic+National+Sample%3A+the+Role+of+Conventional+Risk+Factors+and+Allostatic+Load&rft.au=Nelson%2C+Karin+M%3BReiber%2C+Gayle%3BKohler%2C+Ted%3BBoyko%2C+Edward+J&rft.aulast=Nelson&rft.aufirst=Karin&rft.date=2007-09-01&rft.volume=17&rft.issue=4&rft.spage=669&rft.isbn=&rft.btitle=&rft.title=Ethnicity+%26+Disease&rft.issn=1049510X&rft_id=info:doi/10.1043%2F1049-510X%282007%29172.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cardiovascular system; hypertension; physical activity; Nutrition; Ethnic groups DO - http://dx.doi.org/10.1043/1049-510X(2007)17[669:PADIAM]2.0.CO;2 ER - TY - JOUR T1 - Diagnostic sensitivity and specificity of the radionuclide (indium)-labeled leukocyte scan AN - 20302144; 7585442 AB - Objective Evaluate the sensitivity and specificity of Indium111-labeled leukocyte scans as used in a general, tertiary care hospital. Methods Retrospective review of electronic medical records from all patients who underwent Indium111 scan at two large Veterans Affairs Medical Centers, 1999-2005, to determine congruence between Indium111 scan readings and final clinical diagnoses, using all available data with at least 6 months of follow-up. Results Of 145 indium scans done for possible skeletal infection, infection was judged to be present in 52 cases. The sensitivity was 83%, and the specificity was 90%, with a diagnostic accuracy of 88%. Fifty-nine scans were done for indications other than skeletal infection. In 20 instances, when specific foci were suspected, the suspicion was correctly confirmed by indium scan in every case, without false positives or negatives (sensitivity and specificity, 100%). In 39 scans done to search for a possible source of nonspecific findings of infection (fever, leukocytosis, bacteremia), the sensitivity and specificity were 81% and 87%, respectively, with a diagnostic accuracy of 85%. Conclusion Except as a means to confirm an already-suspected clinical focus, the indium scan appears to offer relatively little definitive information that can be used for diagnosis or treatment of infection. JF - Journal of Infection AU - Wanahita, Anna AU - Villeda, Christian AU - Kutka, Nicolas AU - Ramirez, Julio AU - Musher, Daniel AD - Medical Service (Infectious Disease Section), Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA, daniel.musher@med.va.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 214 EP - 219 PB - W.B. Saunders Co. Ltd., 32 Jamestown Rd London NW1 7BY UK, [URL:http://www.harcourt-international.com] VL - 55 IS - 3 SN - 0163-4453, 0163-4453 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Indium-labeled leukocyte scan KW - Radionuclide scan KW - Leukocyte KW - Fever of unknown origin KW - Osteomyelitis KW - Fever KW - Leukocytosis KW - Leukocytes KW - Radioisotopes KW - Bacteremia KW - Infection KW - electronic medical records KW - Hospitals KW - F 06900:Methods KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20302144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infection&rft.atitle=Diagnostic+sensitivity+and+specificity+of+the+radionuclide+%28indium%29-labeled+leukocyte+scan&rft.au=Wanahita%2C+Anna%3BVilleda%2C+Christian%3BKutka%2C+Nicolas%3BRamirez%2C+Julio%3BMusher%2C+Daniel&rft.aulast=Wanahita&rft.aufirst=Anna&rft.date=2007-09-01&rft.volume=55&rft.issue=3&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infection&rft.issn=01634453&rft_id=info:doi/10.1016%2Fj.jinf.2007.04.352 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fever; Leukocytosis; Leukocytes; Radioisotopes; Bacteremia; Infection; electronic medical records; Hospitals DO - http://dx.doi.org/10.1016/j.jinf.2007.04.352 ER - TY - JOUR T1 - State of the Art Review: Promoting Physical Activity in Primary Care Settings: A Review of Cognitive and Behavioral Strategies AN - 20073999; 10091345 AB - Despite recognition that physical activity is associated with numerous health benefits, many Americans do not meet current guidelines for physical activity. Primary care providers are in a unique position to influence physical activity, though conflicting evidence exists regarding the effectiveness of primary care-based physical activity promotion. The present article provides a qualitative review of the literature on physical activity promotion within primary care settings, focusing specifically on types of cognitive and behavioral intervention strategies that can be implemented into routine practice by primary care providers. The authors searched MEDLINE and identified 16 studies that met relevant experimental, intervention, and outcome criteria. Intervention types were defined as those involving education, advice, self-monitoring, face-to-face counseling, and telephone follow-up. Most interventions included multiple components. Within the limitations of the review, results suggest that a variety of interventions are effective at increasing physical activity and/or fitness of middle-aged and older adults, among both men and women. More research is needed to determine which interventions are most effective in which doses and combinations, with ethnic minorities and younger adults, and regarding long-term outcomes. JF - American Journal of Lifestyle Medicine AU - Smitherman, Todd A AU - Kendzor, Darla E AU - Grothe, Karen B AU - Dubbert, Patricia M AD - University of Mississippi Medical Center, Jackson, Mississippi, patricia.dubbert@med.va.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 397 EP - 409 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 1 IS - 5 SN - 1559-8276, 1559-8276 KW - Physical Education Index KW - Women (physical fitness) KW - Education KW - Promotion KW - Strategy KW - Women KW - Exercise KW - Adults KW - Practice KW - Lifestyle KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20073999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Lifestyle+Medicine&rft.atitle=State+of+the+Art+Review%3A+Promoting+Physical+Activity+in+Primary+Care+Settings%3A+A+Review+of+Cognitive+and+Behavioral+Strategies&rft.au=Smitherman%2C+Todd+A%3BKendzor%2C+Darla+E%3BGrothe%2C+Karen+B%3BDubbert%2C+Patricia+M&rft.aulast=Smitherman&rft.aufirst=Todd&rft.date=2007-09-01&rft.volume=1&rft.issue=5&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Lifestyle+Medicine&rft.issn=15598276&rft_id=info:doi/10.1177%2F1559827607303303. LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Education; Women (physical fitness); Promotion; Women; Strategy; Adults; Exercise; Practice; Lifestyle DO - http://dx.doi.org/10.1177/1559827607303303. ER - TY - JOUR T1 - Intraoperative Ultrasound-Fluoroscopy Fusion can Enhance Prostate Brachytherapy Quality AN - 19464530; 8114068 AB - Purpose To evaluate a transrectal ultrasound (TRUS)-fluoroscopy fusion-based intraoperative dosimetry system. Method and Materials Twenty-five patients were treated for prostate cancer with Pd-103 implantation. After the execution of the treatment plan, two sets of TRUS images were collected using the longitudinal and axial transducers of a biplanar probe. Then, three fluoroscopic images were acquired at 0, -15 and +15°. The three-dimensional locations of all implanted seeds were reconstructed from fluoroscopic images. A subset of the implanted seeds was manually identified in TRUS images and used as fiducial markers to perform TRUS-fluoroscopy fusion. To improve the implant quality, additional seeds were placed if adverse isodose patterns were identified during visual inspection. If additional seeds were placed, intraoperative dosimetry was repeated. Day 0 computed tomography-based dosimetry was compared with final intraoperative dosimetry to validate dosimetry achieved in the implant suite. Results An average of additional 4.0 seeds was implanted in 16 patients after initial intraoperative dose evaluation. Based on TRUS-fluoroscopy fusion-based dosimetry, the V100 improved from 86% to 93% (p = 0.005), whereas D90 increased from 94% to 109% (p = 0.011) with the guided additional seed implantation. No statistical difference was observed in V200 and V300 values. V100 and D90 values were 95 ± 4% and 120 ± 24%, respectively, based on the final intraoperative dosimetry evaluation, compared with 95 ± 4% and 122 ± 24%, respectively, based on Day 0 computed tomography-based dosimetry. Conclusions Implantation of extra seeds based on TRUS-fluoroscopy fusion-based intraoperative dosimetry can improve the final V100 and D90 values with minimal increase in V200 and V300 values. JF - International Journal of Radiation Oncology, Biology, & Physics AU - Orio III, Peter F AU - Tutar, Ismail B AU - Sreeram, Narayanan AU - Arthurs, Sandra AU - Cho, Paul S AU - Kim, Yongmin AU - Merrick, Gregory AU - Wallner, Kent E AD - Schiffler Cancer Center, Wheeling, WV, kent.wallner@med.va.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 302 EP - 307 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 69 IS - 1 SN - 0360-3016, 0360-3016 KW - Biotechnology and Bioengineering Abstracts KW - Prostate KW - Brachytherapy KW - Dosimetry KW - Pd-103 KW - Seeds KW - Statistics KW - Prostate cancer KW - Computed tomography KW - Probes KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19464530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.atitle=Intraoperative+Ultrasound-Fluoroscopy+Fusion+can+Enhance+Prostate+Brachytherapy+Quality&rft.au=Orio+III%2C+Peter+F%3BTutar%2C+Ismail+B%3BSreeram%2C+Narayanan%3BArthurs%2C+Sandra%3BCho%2C+Paul+S%3BKim%2C+Yongmin%3BMerrick%2C+Gregory%3BWallner%2C+Kent+E&rft.aulast=Orio+III&rft.aufirst=Peter&rft.date=2007-09-01&rft.volume=69&rft.issue=1&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.issn=03603016&rft_id=info:doi/10.1016%2Fj.ijrobp.2007.04.072 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Seeds; Prostate cancer; Brachytherapy; Statistics; Computed tomography; Dosimetry; Probes; Ultrasound DO - http://dx.doi.org/10.1016/j.ijrobp.2007.04.072 ER - TY - RPRT T1 - FORT ROSENCRANS NATIONAL CEMETERY ANNEX AT MCAS MIRAMAR, COUNTY OF SAN DIEGO, CALIFORNIA. [Part 3 of 3] T2 - FORT ROSENCRANS NATIONAL CEMETERY ANNEX AT MCAS MIRAMAR, COUNTY OF SAN DIEGO, CALIFORNIA. AN - 756824505; 12921-070378_0003 AB - PURPOSE: The implementation of a land use agreement between the U.S. Department of the Navy and the U.S. Department of Veterans Affairs (VA) is proposed to provide for the construction and operation of an annex to the existing Fort Rosecrans National Cemetery at Point Loma in San Diego, California. The annex would be located at Marine Corps Air Station (MCAS) Miramar in San Diego. To fulfill its mission to provide funeral services and cemetery accommodations to veterans, the National Cemetery Administration (NCA) of the VA to provide cemetery services to veterans and other eligible persons. Since 1973, the interment rate in VA national cemeteries has increased by more than 15 percent, from 36,400 in 1973 to more than 93,000 in 2004. Interments are expected to continue increasing until 2008. The upward trend in veteran deaths results in a corresponding increase in the demand for interments in national cemeteries. Experience and recent historical data have shown that over 80 percent of persons interred in national cemeteries resided within 75 miles of the cemetery at the time of death. Therefore, NCA considers reasonable access to burial benefits to mean that a first interment option, for casketed or cremated remains in a national or state veterans' cemetery, is available within 75 miles of the veteran's place of residence. There are two other national cemeteries in southern California, namely, Los Angeles National Cemetery, located in western Los Angeles approximately 130 miles from San Diego, and Riverside National Cemetery, located adjacent to March Air Force Reserve Base approximately 90 miles from San Diego. The VA operates Fort Rosecrans National Cemetery, a 77-acre site located on a federal land withdrawal held by the Navy for military purposes in the center of the Point Loma peninsula. The National Cemetery Act of 1973 transferred administration of this tract to the VA. It is the only national cemetery in San Diego County and has been closed to first interment casketed burials since 1966. Approximately seven acres of additional land were acquired from Naval Base Point Loma in 2002. The NCA recently completed the construction of columbarium niches to provide for cremation burial options to San Diego veterans. With the availability of these niches as a burial option, the demand has been high. The NCA has therefore recognized the need for additional burial space for the 253,000 San Diego area military veterans, 23 percent of whom are expected to require interment over the next 20 years, that figure rising to 35 percent by 2035. At this rate, the columbarium niches are being rapidly depleted as the only first interment burial option available at this cemetery; the existing niches will provide adequate space until 2008. No addition land is available for expansion at Fort Rosecrans or Naval Base Point Loma. Under the proposed land use agreement at hand, the Department of the Navy has identified four potential sites at MCAS Miramar for the construction and operation of an annex to the Fort Rosecrans National Cemetery. Under the preferred alternative, the annex would be located on a 323-acre tract lying east of Interstate 805 and Nobel Drive within MCAS Miramar. Approximately 214 acres within the site would be developed as the annex. The annex would be developed in phases over a minimum 40-year planning period to meet the identified need for a minimum of 50,000 casketed gravesites and 40,000 columbarium niches. The facility would include entrance and external access roads, an 870-square-foot public information center for visitors, two committal service shelters for away-from-gravesite interment services, administrative and maintenance complexes, and parking facilities. In addition to the preferred alternative, one site alternative and a No Action Alternative are considered in this final EIS. POSITIVE IMPACTS: The annex would help achieve the mission of the NCA to honor veterans with a final resting place and lasting memorials that commemorate their service to the nation. NEGATIVE IMPACTS: Development of the preferred site could negatively affect five archaeological sites, two of which have been declared eligible for inclusion in the National Register of Historic Places, while the other three are currently being evaluated for eligibility. In addition, the annex would displace 12.07 acres of recently occupied coastal California gnatcatcher habitat and 200.63 acres of potential, though unoccupied, gnatcatcher habitat, 29 basins providing habitat for other federally protected species; compensation habitat would be provided in both cases. Operation of the cemetery would result in gatherings of more than 25 persons per acre in an accident potential zone, a situation that would be incompatible with MCAS Miramar land use regulations. LEGAL MANDATES: National Cemetery Act of 1973 (83 Stat. 75) and National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstract of the draft EIS, see 06-0480D, Volume 30, Number 4. JF - EPA number: 070378, 697 pages and maps, August 31, 2007 PY - 2007 VL - 3 KW - Defense Programs KW - Air Quality Assessments KW - Archaeological Sites KW - Cemeteries KW - Coastal Zones KW - Endangered Species (Animals) KW - Parking KW - Roads KW - Safety KW - Traffic Analyses KW - Wetlands KW - Fort Rosencrans National Cemetery KW - California KW - Marine Corps Air Station Miramar KW - National Cemetery Act of 1973, Project Authorization KW - National Historic Preservation Act of 1966, Archaeological Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756824505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2007-08-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=FORT+ROSENCRANS+NATIONAL+CEMETERY+ANNEX+AT+MCAS+MIRAMAR%2C+COUNTY+OF+SAN+DIEGO%2C+CALIFORNIA.&rft.title=FORT+ROSENCRANS+NATIONAL+CEMETERY+ANNEX+AT+MCAS+MIRAMAR%2C+COUNTY+OF+SAN+DIEGO%2C+CALIFORNIA.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of the Navy, Naval Facilities Engineering Command, San Diego, California; NAVY N1 - Date revised - 2008-04-01 N1 - SuppNotes - Final. Preparation date: August 31, 2007 N1 - Last updated - 2011-12-16 ER - TY - RPRT T1 - FORT ROSENCRANS NATIONAL CEMETERY ANNEX AT MCAS MIRAMAR, COUNTY OF SAN DIEGO, CALIFORNIA. [Part 2 of 3] T2 - FORT ROSENCRANS NATIONAL CEMETERY ANNEX AT MCAS MIRAMAR, COUNTY OF SAN DIEGO, CALIFORNIA. AN - 756824479; 12921-070378_0002 AB - PURPOSE: The implementation of a land use agreement between the U.S. Department of the Navy and the U.S. Department of Veterans Affairs (VA) is proposed to provide for the construction and operation of an annex to the existing Fort Rosecrans National Cemetery at Point Loma in San Diego, California. The annex would be located at Marine Corps Air Station (MCAS) Miramar in San Diego. To fulfill its mission to provide funeral services and cemetery accommodations to veterans, the National Cemetery Administration (NCA) of the VA to provide cemetery services to veterans and other eligible persons. Since 1973, the interment rate in VA national cemeteries has increased by more than 15 percent, from 36,400 in 1973 to more than 93,000 in 2004. Interments are expected to continue increasing until 2008. The upward trend in veteran deaths results in a corresponding increase in the demand for interments in national cemeteries. Experience and recent historical data have shown that over 80 percent of persons interred in national cemeteries resided within 75 miles of the cemetery at the time of death. Therefore, NCA considers reasonable access to burial benefits to mean that a first interment option, for casketed or cremated remains in a national or state veterans' cemetery, is available within 75 miles of the veteran's place of residence. There are two other national cemeteries in southern California, namely, Los Angeles National Cemetery, located in western Los Angeles approximately 130 miles from San Diego, and Riverside National Cemetery, located adjacent to March Air Force Reserve Base approximately 90 miles from San Diego. The VA operates Fort Rosecrans National Cemetery, a 77-acre site located on a federal land withdrawal held by the Navy for military purposes in the center of the Point Loma peninsula. The National Cemetery Act of 1973 transferred administration of this tract to the VA. It is the only national cemetery in San Diego County and has been closed to first interment casketed burials since 1966. Approximately seven acres of additional land were acquired from Naval Base Point Loma in 2002. The NCA recently completed the construction of columbarium niches to provide for cremation burial options to San Diego veterans. With the availability of these niches as a burial option, the demand has been high. The NCA has therefore recognized the need for additional burial space for the 253,000 San Diego area military veterans, 23 percent of whom are expected to require interment over the next 20 years, that figure rising to 35 percent by 2035. At this rate, the columbarium niches are being rapidly depleted as the only first interment burial option available at this cemetery; the existing niches will provide adequate space until 2008. No addition land is available for expansion at Fort Rosecrans or Naval Base Point Loma. Under the proposed land use agreement at hand, the Department of the Navy has identified four potential sites at MCAS Miramar for the construction and operation of an annex to the Fort Rosecrans National Cemetery. Under the preferred alternative, the annex would be located on a 323-acre tract lying east of Interstate 805 and Nobel Drive within MCAS Miramar. Approximately 214 acres within the site would be developed as the annex. The annex would be developed in phases over a minimum 40-year planning period to meet the identified need for a minimum of 50,000 casketed gravesites and 40,000 columbarium niches. The facility would include entrance and external access roads, an 870-square-foot public information center for visitors, two committal service shelters for away-from-gravesite interment services, administrative and maintenance complexes, and parking facilities. In addition to the preferred alternative, one site alternative and a No Action Alternative are considered in this final EIS. POSITIVE IMPACTS: The annex would help achieve the mission of the NCA to honor veterans with a final resting place and lasting memorials that commemorate their service to the nation. NEGATIVE IMPACTS: Development of the preferred site could negatively affect five archaeological sites, two of which have been declared eligible for inclusion in the National Register of Historic Places, while the other three are currently being evaluated for eligibility. In addition, the annex would displace 12.07 acres of recently occupied coastal California gnatcatcher habitat and 200.63 acres of potential, though unoccupied, gnatcatcher habitat, 29 basins providing habitat for other federally protected species; compensation habitat would be provided in both cases. Operation of the cemetery would result in gatherings of more than 25 persons per acre in an accident potential zone, a situation that would be incompatible with MCAS Miramar land use regulations. LEGAL MANDATES: National Cemetery Act of 1973 (83 Stat. 75) and National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstract of the draft EIS, see 06-0480D, Volume 30, Number 4. JF - EPA number: 070378, 697 pages and maps, August 31, 2007 PY - 2007 VL - 2 KW - Defense Programs KW - Air Quality Assessments KW - Archaeological Sites KW - Cemeteries KW - Coastal Zones KW - Endangered Species (Animals) KW - Parking KW - Roads KW - Safety KW - Traffic Analyses KW - Wetlands KW - Fort Rosencrans National Cemetery KW - California KW - Marine Corps Air Station Miramar KW - National Cemetery Act of 1973, Project Authorization KW - National Historic Preservation Act of 1966, Archaeological Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756824479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2007-08-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=FORT+ROSENCRANS+NATIONAL+CEMETERY+ANNEX+AT+MCAS+MIRAMAR%2C+COUNTY+OF+SAN+DIEGO%2C+CALIFORNIA.&rft.title=FORT+ROSENCRANS+NATIONAL+CEMETERY+ANNEX+AT+MCAS+MIRAMAR%2C+COUNTY+OF+SAN+DIEGO%2C+CALIFORNIA.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of the Navy, Naval Facilities Engineering Command, San Diego, California; NAVY N1 - Date revised - 2008-04-01 N1 - SuppNotes - Final. Preparation date: August 31, 2007 N1 - Last updated - 2011-12-16 ER - TY - RPRT T1 - FORT ROSENCRANS NATIONAL CEMETERY ANNEX AT MCAS MIRAMAR, COUNTY OF SAN DIEGO, CALIFORNIA. [Part 1 of 3] T2 - FORT ROSENCRANS NATIONAL CEMETERY ANNEX AT MCAS MIRAMAR, COUNTY OF SAN DIEGO, CALIFORNIA. AN - 756824446; 12921-070378_0001 AB - PURPOSE: The implementation of a land use agreement between the U.S. Department of the Navy and the U.S. Department of Veterans Affairs (VA) is proposed to provide for the construction and operation of an annex to the existing Fort Rosecrans National Cemetery at Point Loma in San Diego, California. The annex would be located at Marine Corps Air Station (MCAS) Miramar in San Diego. To fulfill its mission to provide funeral services and cemetery accommodations to veterans, the National Cemetery Administration (NCA) of the VA to provide cemetery services to veterans and other eligible persons. Since 1973, the interment rate in VA national cemeteries has increased by more than 15 percent, from 36,400 in 1973 to more than 93,000 in 2004. Interments are expected to continue increasing until 2008. The upward trend in veteran deaths results in a corresponding increase in the demand for interments in national cemeteries. Experience and recent historical data have shown that over 80 percent of persons interred in national cemeteries resided within 75 miles of the cemetery at the time of death. Therefore, NCA considers reasonable access to burial benefits to mean that a first interment option, for casketed or cremated remains in a national or state veterans' cemetery, is available within 75 miles of the veteran's place of residence. There are two other national cemeteries in southern California, namely, Los Angeles National Cemetery, located in western Los Angeles approximately 130 miles from San Diego, and Riverside National Cemetery, located adjacent to March Air Force Reserve Base approximately 90 miles from San Diego. The VA operates Fort Rosecrans National Cemetery, a 77-acre site located on a federal land withdrawal held by the Navy for military purposes in the center of the Point Loma peninsula. The National Cemetery Act of 1973 transferred administration of this tract to the VA. It is the only national cemetery in San Diego County and has been closed to first interment casketed burials since 1966. Approximately seven acres of additional land were acquired from Naval Base Point Loma in 2002. The NCA recently completed the construction of columbarium niches to provide for cremation burial options to San Diego veterans. With the availability of these niches as a burial option, the demand has been high. The NCA has therefore recognized the need for additional burial space for the 253,000 San Diego area military veterans, 23 percent of whom are expected to require interment over the next 20 years, that figure rising to 35 percent by 2035. At this rate, the columbarium niches are being rapidly depleted as the only first interment burial option available at this cemetery; the existing niches will provide adequate space until 2008. No addition land is available for expansion at Fort Rosecrans or Naval Base Point Loma. Under the proposed land use agreement at hand, the Department of the Navy has identified four potential sites at MCAS Miramar for the construction and operation of an annex to the Fort Rosecrans National Cemetery. Under the preferred alternative, the annex would be located on a 323-acre tract lying east of Interstate 805 and Nobel Drive within MCAS Miramar. Approximately 214 acres within the site would be developed as the annex. The annex would be developed in phases over a minimum 40-year planning period to meet the identified need for a minimum of 50,000 casketed gravesites and 40,000 columbarium niches. The facility would include entrance and external access roads, an 870-square-foot public information center for visitors, two committal service shelters for away-from-gravesite interment services, administrative and maintenance complexes, and parking facilities. In addition to the preferred alternative, one site alternative and a No Action Alternative are considered in this final EIS. POSITIVE IMPACTS: The annex would help achieve the mission of the NCA to honor veterans with a final resting place and lasting memorials that commemorate their service to the nation. NEGATIVE IMPACTS: Development of the preferred site could negatively affect five archaeological sites, two of which have been declared eligible for inclusion in the National Register of Historic Places, while the other three are currently being evaluated for eligibility. In addition, the annex would displace 12.07 acres of recently occupied coastal California gnatcatcher habitat and 200.63 acres of potential, though unoccupied, gnatcatcher habitat, 29 basins providing habitat for other federally protected species; compensation habitat would be provided in both cases. Operation of the cemetery would result in gatherings of more than 25 persons per acre in an accident potential zone, a situation that would be incompatible with MCAS Miramar land use regulations. LEGAL MANDATES: National Cemetery Act of 1973 (83 Stat. 75) and National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstract of the draft EIS, see 06-0480D, Volume 30, Number 4. JF - EPA number: 070378, 697 pages and maps, August 31, 2007 PY - 2007 VL - 1 KW - Defense Programs KW - Air Quality Assessments KW - Archaeological Sites KW - Cemeteries KW - Coastal Zones KW - Endangered Species (Animals) KW - Parking KW - Roads KW - Safety KW - Traffic Analyses KW - Wetlands KW - Fort Rosencrans National Cemetery KW - California KW - Marine Corps Air Station Miramar KW - National Cemetery Act of 1973, Project Authorization KW - National Historic Preservation Act of 1966, Archaeological Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756824446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2007-08-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=FORT+ROSENCRANS+NATIONAL+CEMETERY+ANNEX+AT+MCAS+MIRAMAR%2C+COUNTY+OF+SAN+DIEGO%2C+CALIFORNIA.&rft.title=FORT+ROSENCRANS+NATIONAL+CEMETERY+ANNEX+AT+MCAS+MIRAMAR%2C+COUNTY+OF+SAN+DIEGO%2C+CALIFORNIA.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of the Navy, Naval Facilities Engineering Command, San Diego, California; NAVY N1 - Date revised - 2008-04-01 N1 - SuppNotes - Final. Preparation date: August 31, 2007 N1 - Last updated - 2011-12-16 ER - TY - RPRT T1 - FORT ROSENCRANS NATIONAL CEMETERY ANNEX AT MCAS MIRAMAR, COUNTY OF SAN DIEGO, CALIFORNIA. AN - 36343230; 12921 AB - PURPOSE: The implementation of a land use agreement between the U.S. Department of the Navy and the U.S. Department of Veterans Affairs (VA) is proposed to provide for the construction and operation of an annex to the existing Fort Rosecrans National Cemetery at Point Loma in San Diego, California. The annex would be located at Marine Corps Air Station (MCAS) Miramar in San Diego. To fulfill its mission to provide funeral services and cemetery accommodations to veterans, the National Cemetery Administration (NCA) of the VA to provide cemetery services to veterans and other eligible persons. Since 1973, the interment rate in VA national cemeteries has increased by more than 15 percent, from 36,400 in 1973 to more than 93,000 in 2004. Interments are expected to continue increasing until 2008. The upward trend in veteran deaths results in a corresponding increase in the demand for interments in national cemeteries. Experience and recent historical data have shown that over 80 percent of persons interred in national cemeteries resided within 75 miles of the cemetery at the time of death. Therefore, NCA considers reasonable access to burial benefits to mean that a first interment option, for casketed or cremated remains in a national or state veterans' cemetery, is available within 75 miles of the veteran's place of residence. There are two other national cemeteries in southern California, namely, Los Angeles National Cemetery, located in western Los Angeles approximately 130 miles from San Diego, and Riverside National Cemetery, located adjacent to March Air Force Reserve Base approximately 90 miles from San Diego. The VA operates Fort Rosecrans National Cemetery, a 77-acre site located on a federal land withdrawal held by the Navy for military purposes in the center of the Point Loma peninsula. The National Cemetery Act of 1973 transferred administration of this tract to the VA. It is the only national cemetery in San Diego County and has been closed to first interment casketed burials since 1966. Approximately seven acres of additional land were acquired from Naval Base Point Loma in 2002. The NCA recently completed the construction of columbarium niches to provide for cremation burial options to San Diego veterans. With the availability of these niches as a burial option, the demand has been high. The NCA has therefore recognized the need for additional burial space for the 253,000 San Diego area military veterans, 23 percent of whom are expected to require interment over the next 20 years, that figure rising to 35 percent by 2035. At this rate, the columbarium niches are being rapidly depleted as the only first interment burial option available at this cemetery; the existing niches will provide adequate space until 2008. No addition land is available for expansion at Fort Rosecrans or Naval Base Point Loma. Under the proposed land use agreement at hand, the Department of the Navy has identified four potential sites at MCAS Miramar for the construction and operation of an annex to the Fort Rosecrans National Cemetery. Under the preferred alternative, the annex would be located on a 323-acre tract lying east of Interstate 805 and Nobel Drive within MCAS Miramar. Approximately 214 acres within the site would be developed as the annex. The annex would be developed in phases over a minimum 40-year planning period to meet the identified need for a minimum of 50,000 casketed gravesites and 40,000 columbarium niches. The facility would include entrance and external access roads, an 870-square-foot public information center for visitors, two committal service shelters for away-from-gravesite interment services, administrative and maintenance complexes, and parking facilities. In addition to the preferred alternative, one site alternative and a No Action Alternative are considered in this final EIS. POSITIVE IMPACTS: The annex would help achieve the mission of the NCA to honor veterans with a final resting place and lasting memorials that commemorate their service to the nation. NEGATIVE IMPACTS: Development of the preferred site could negatively affect five archaeological sites, two of which have been declared eligible for inclusion in the National Register of Historic Places, while the other three are currently being evaluated for eligibility. In addition, the annex would displace 12.07 acres of recently occupied coastal California gnatcatcher habitat and 200.63 acres of potential, though unoccupied, gnatcatcher habitat, 29 basins providing habitat for other federally protected species; compensation habitat would be provided in both cases. Operation of the cemetery would result in gatherings of more than 25 persons per acre in an accident potential zone, a situation that would be incompatible with MCAS Miramar land use regulations. LEGAL MANDATES: National Cemetery Act of 1973 (83 Stat. 75) and National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstract of the draft EIS, see 06-0480D, Volume 30, Number 4. JF - EPA number: 070378, 697 pages and maps, August 31, 2007 PY - 2007 KW - Defense Programs KW - Air Quality Assessments KW - Archaeological Sites KW - Cemeteries KW - Coastal Zones KW - Endangered Species (Animals) KW - Parking KW - Roads KW - Safety KW - Traffic Analyses KW - Wetlands KW - Fort Rosencrans National Cemetery KW - California KW - Marine Corps Air Station Miramar KW - National Cemetery Act of 1973, Project Authorization KW - National Historic Preservation Act of 1966, Archaeological Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36343230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2007-08-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=FORT+ROSENCRANS+NATIONAL+CEMETERY+ANNEX+AT+MCAS+MIRAMAR%2C+COUNTY+OF+SAN+DIEGO%2C+CALIFORNIA.&rft.title=FORT+ROSENCRANS+NATIONAL+CEMETERY+ANNEX+AT+MCAS+MIRAMAR%2C+COUNTY+OF+SAN+DIEGO%2C+CALIFORNIA.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of the Navy, Naval Facilities Engineering Command, San Diego, California; NAVY N1 - Date revised - 2008-04-01 N1 - SuppNotes - Final. Preparation date: August 31, 2007 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Sex Differences in the Experience of Unwanted Sexual Attention and Behaviors During Childhood AN - 61672029; 200801439 AB - Girls receive considerable amounts of unwanted sexual attention (UWSA) and behaviors (UWSB). Less is known about boys' unwanted sexual experiences. The primary goal of this study was to obtain a descriptive profile of the types and perpetrators of childhood UWSA/B. Secondary goals were to examine sex differences in emotional reactions to UWSA/B and influence of perpetrator. As many as100 male and 100 female undergraduates completed the Exposure to Sexual Attention Scale and the Emotional Reaction Checklist. Results indicated that the majority of participants experienced UWSA/B during childhood, with females reporting higher rates of UWSB than males. Sex differences were also observed regarding types of perpetrators and emotional reactions. Findings are discussed as they relate to the sociocultural norms in which children are reared. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Child Sexual Abuse AU - Whealin, Julia M AU - Zinzow, Heidi M AU - Salstrom, Seoka A AU - Jackson, Joan L AD - Deputy Director, Education and Research Health Scientist, National Center for PTSD, Honolulu, HI, 96744 julia.whealin@va.gov Y1 - 2007/08/16/ PY - 2007 DA - 2007 Aug 16 SP - 41 EP - 58 PB - Haworth Press, Binghamton NY VL - 16 IS - 3 SN - 1053-8712, 1053-8712 KW - Undergraduate Students KW - Childhood KW - Sexual Harassment KW - Sex Differences KW - Children KW - Child Sexual Abuse KW - article KW - 2190: social problems and social welfare; victimology (rape, family violence, & child abuse) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61672029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Sexual+Abuse&rft.atitle=Sex+Differences+in+the+Experience+of+Unwanted+Sexual+Attention+and+Behaviors+During+Childhood&rft.au=Whealin%2C+Julia+M%3BZinzow%2C+Heidi+M%3BSalstrom%2C+Seoka+A%3BJackson%2C+Joan+L&rft.aulast=Whealin&rft.aufirst=Julia&rft.date=2007-08-16&rft.volume=16&rft.issue=3&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Sexual+Abuse&rft.issn=10538712&rft_id=info:doi/10.1300%2FJ070v16n03_03 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-01-04 N1 - Last updated - 2016-09-28 N1 - CODEN - JCABEK N1 - SubjectsTermNotLitGenreText - Child Sexual Abuse; Sex Differences; Sexual Harassment; Childhood; Children; Undergraduate Students DO - http://dx.doi.org/10.1300/J070v16n03_03 ER - TY - JOUR T1 - Transverse Myelitis in 2 Patients With Bartonella henselae Infection (Cat Scratch Disease) AN - 20850062; 8231446 AB - Cat scratch disease Is usually a benign, self-limiting condition. Neurological manifestations are uncommon and may consist of encephalopathy, seizures, and coma. This report describes 2 cases of transverse myelitis: 1 case in a 46-year-old man who had lymph node biopsy and serological testing results that were positive for Bartonella henselae and 1 case in a 13-year-old adolescent boy who had serological testing results that were positive for B. henselae. These are 2 of the only 3 cases of transverse myelitis associated with cat scratch disease that have been reported since the causative organism was first reported. JF - Clinical Infectious Diseases AU - Baylor, P AU - Garoufi, A AU - Karpathios, T AU - Lutz, J AU - Mogelof, J AU - Moseley, D AD - 2615 E. Clinton Ave., Fresno, CA 93703, USA, Peter.Baylor@va.gov Y1 - 2007/08/15/ PY - 2007 DA - 2007 Aug 15 SP - e42 EP - e45 VL - 45 IS - 4 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - Cat scratch disease KW - Coma KW - Adolescence KW - Seizures KW - Bartonella henselae KW - Myelitis KW - Biopsy KW - Encephalopathy KW - Infection KW - Lymph nodes KW - Benign KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20850062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Transverse+Myelitis+in+2+Patients+With+Bartonella+henselae+Infection+%28Cat+Scratch+Disease%29&rft.au=Baylor%2C+P%3BGaroufi%2C+A%3BKarpathios%2C+T%3BLutz%2C+J%3BMogelof%2C+J%3BMoseley%2C+D&rft.aulast=Baylor&rft.aufirst=P&rft.date=2007-08-15&rft.volume=45&rft.issue=4&rft.spage=e42&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Coma; Cat scratch disease; Adolescence; Seizures; Biopsy; Myelitis; Infection; Encephalopathy; Lymph nodes; Benign; Bartonella henselae ER - TY - JOUR T1 - Auditory Performance Characteristics of the Computerized Revised Token Test (CRTT) AN - 85683376; 200802300 AB - Purpose: To assess the Computerized Revised Token Test (CRTT) performance of individuals with normal hearing under several intensity conditions and under several spectral and temporal perturbation conditions. Method: Sixty normal-hearing listeners were randomly assigned to 1 of 3 groups. Group 1 provided performance-intensity information about CRTT performance using uncompressed acoustic stimuli. Groups 2 and 3 completed the CRTT using temporally and spectrally compressed and expanded stimuli. CRTT performance functions were plotted for each group. Results: Group 1 required minimal audibility to perform maximally on this task. As expected, Groups 2 and 3 showed significant differences across subtests, regardless of distortion condition. Mean differences in performance between successive conditions for Group 2 increased beyond 40% time compressed. There was 1 significant difference for the time-expanded condition. There were no differences across frequency compressed and expanded conditions. Conclusion: Young listeners require limited signal gain on the CRTT to achieve maximum performance. Time and frequency compression and expansion results were consistent with previous findings with varying types of speech stimuli. The results have implications for administration and interpretation of the CRTT administered to persons from other populations and will help in the development of a normative database for the CRTT. Adapted from the source document JF - Journal of Speech, Language, and Hearing Research AU - Eberwein, Cynthia A AU - Pratt, Sheila R AU - McNeil, Malcolm R AU - Fossett, Tepanta R D AU - Szuminsky, Neil J AU - Doyle, Patrick J AD - VA Pittsburgh Healthcare System, Audiology and Speech Pathology, 7180 Highland Drive, Pittsburgh, PA 15206. Cynthia.Eberwein@va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 865 EP - 877 VL - 50 IS - 4 SN - 1092-4388, 1092-4388 KW - Hearing (31150) KW - Audiometry (05600) KW - Diagnostic Tests (18550) KW - Auditory Processing (05920) KW - Test Validity and Reliability (88800) KW - article KW - 6310: hearing-pathological and normal; hearing-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85683376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=Auditory+Performance+Characteristics+of+the+Computerized+Revised+Token+Test+%28CRTT%29&rft.au=Eberwein%2C+Cynthia+A%3BPratt%2C+Sheila+R%3BMcNeil%2C+Malcolm+R%3BFossett%2C+Tepanta+R+D%3BSzuminsky%2C+Neil+J%3BDoyle%2C+Patrick+J&rft.aulast=Eberwein&rft.aufirst=Cynthia&rft.date=2007-08-01&rft.volume=50&rft.issue=4&rft.spage=865&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2009-04-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Auditory Processing (05920); Test Validity and Reliability (88800); Audiometry (05600); Hearing (31150); Diagnostic Tests (18550) ER - TY - JOUR T1 - An Evaluation of the BKB-SIN, HINT, QuickSIN, and WIN Materials on Listeners With Normal Hearing and Listeners With Hearing Loss. AN - 85406828; pmid-17675590 AB - The purpose of this study was to examine in listeners with normal hearing and listeners with sensorineural hearing loss the within- and between-group differences obtained with 4 commonly available speech-in-noise protocols.Recognition performances by 24 listeners with normal hearing and 72 listeners with sensorineural hearing loss were compared for 4 speech-in-noise protocols that varied with respect to the amount of contextual cues conveyed in the target signal. The protocols studied included the Bamford-Kowal-Bench Speech-in-Noise Test (BKB-SIN; Etymōtic Research, 2005; J. Bench, A. Kowal, & J. Bamford, 1979; P. Niquette et al., 2003), the Quick Speech-in-Noise Test (QuickSIN; M. C. Killion, P. A. Niquette, G. I. Gudmundsen, L. J. Revit, & S. Banerjee, 2004), and the Words-in-Noise test (WIN; R. H. Wilson, 2003; R. H. Wilson & C. A. Burks, 2005), each of which used multitalker babble and a modified method of constants, as well as the Hearing in Noise Test (HINT; M. Nilsson, S. Soli, & J. Sullivan, 1994), which used speech-spectrum noise and an adaptive psychophysical procedure.The 50% points for the listeners with normal hearing were in the 1- to 4-dB signal-to-babble ratio (S/B) range and for the listeners with hearing loss in the 5- to 14-dB S/B range. Separation between groups was least with the BKB-SIN and HINT (4-6 dB) and most with the QuickSIN and WIN (8-10 dB).The QuickSIN and WIN materials are more sensitive measures of recognition performance in background noise than are the BKB-SIN and HINT materials. JF - Journal of speech, language, and hearing research : JSLHR AU - Wilson, Richard H AU - McArdle, Rachel A AU - Smith, Sherri L AD - James H. Quillen VA Medical Center, Audiology 126, Mountain Home, TN 37684, USA. richard.wilson2@va.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 844 EP - 856 VL - 50 IS - 4 SN - 1092-4388, 1092-4388 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation KW - Adolescent KW - Adult KW - Audiometry, Pure-Tone KW - *Audiometry, Speech: methods KW - Female KW - *Hearing KW - *Hearing Loss, Sensorineural: diagnosis KW - Humans KW - Male KW - Noise KW - Psychometrics KW - *Speech Perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85406828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.atitle=An+Evaluation+of+the+BKB-SIN%2C+HINT%2C+QuickSIN%2C+and+WIN+Materials+on+Listeners+With+Normal+Hearing+and+Listeners+With+Hearing+Loss.&rft.au=Wilson%2C+Richard+H%3BMcArdle%2C+Rachel+A%3BSmith%2C+Sherri+L&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2007-08-01&rft.volume=50&rft.issue=4&rft.spage=844&rft.isbn=&rft.btitle=&rft.title=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.issn=10924388&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Interpretation of the adult polysomnogram. AN - 85395783; pmid-17606020 AB - Polysomnography provides information on the physiological changes occurring in many different organ systems in relation to sleep stages and wakefulness. It allows qualitative and quantitative documentation of abnormalities of sleep and wakefulness, of sleep-wake transition, and of physiological function of other organ systems that are influenced by sleep. Polysomnography is considered to be the "gold standard" for diagnosing sleep disordered breathing (SDB) and other sleep disorders; however, as with most other diagnostic tests, polysomnography is not ideal, but is rather the best available method to diagnose SDB. Review of clinical history, pre- and post study questionnaires, medications, and technician's comments at the time of interpreting the PSG provides a unique opportunity to correlate clinical and electrophysiological data, and is a good investment of time toward improving patient outcomes and avoidance of unnecessary testing. JF - Otolaryngologic clinics of North America AU - Kakkar, Rahul K AU - Hill, Gilbert K AD - North Florida South Georgia VAHS Sleep Disorders Center, Malcom Randall Veterans Administration Medical Center, 1601 Archer Road, Gainesville, FL 32608, USA. rahul.kakkar@medicine.ufl.edu Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 713 EP - 743 VL - 40 IS - 4 SN - 0030-6665, 0030-6665 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Cerebral Cortex: physiopathology KW - Electrodes KW - Humans KW - Motor Activity: physiology KW - Polysomnography: instrumentation KW - Pulmonary Ventilation: physiology KW - Reference Values KW - *Sleep Apnea, Obstructive: diagnosis KW - Sleep Apnea, Obstructive: physiopathology KW - Sleep Stages: physiology KW - Snoring: physiopathology KW - Video Recording UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngologic+clinics+of+North+America&rft.atitle=Interpretation+of+the+adult+polysomnogram.&rft.au=Kakkar%2C+Rahul+K%3BHill%2C+Gilbert+K&rft.aulast=Kakkar&rft.aufirst=Rahul&rft.date=2007-08-01&rft.volume=40&rft.issue=4&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Otolaryngologic+clinics+of+North+America&rft.issn=00306665&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - JP-8 jet fuel can promote auditory impairment resulting from subsequent noise exposure in rats. AN - 70761230; 17483120 AB - We report on the transient and persistent effects of JP-8 jet fuel exposure on auditory function in rats. JP-8 has become the standard jet fuel utilized in the United States and North Atlantic Treaty Organization countries for military use and it is closely related to Jet A fuel, which is used in U.S. domestic aviation. Rats received JP-8 fuel (1000 mg/m(3)) by nose-only inhalation for 4 h and half of them were immediately subjected to an octave band of noise ranging between 97 and 105 dB in different experiments. The noise by itself produces a small, but permanent auditory impairment. The current permissible exposure level for JP-8 is 350 mg/m(3). Additionally, a positive control group received only noise exposure, and a fourth group consisted of untreated control subjects. Exposures occurred either on 1 day or repeatedly on 5 successive days. Impairments in auditory function were assessed using distortion product otoacoustic emissions and compound action potential testing. In other rats, tissues were harvested following JP-8 exposure for assessment of hydrocarbon levels or glutathione (GSH) levels. A single JP-8 exposure by itself at 1000 mg/m(3) did not disrupt auditory function. However, exposure to JP-8 and noise produced an additive disruption in outer hair cell function. Repeated 5-day JP-8 exposure at 1000 mg/m(3) for 4 h produced impairment of outer hair cell function that was most evident at the first postexposure assessment time. Partial though not complete recovery was observed over a 4-week postexposure period. The adverse effects of repeated JP-8 exposures on auditory function were inconsistent, but combined treatment with JP-8 + noise yielded greater impairment of auditory function, and hair cell loss than did noise by itself. Qualitative comparison of outer hair cell loss suggests an increase in outer hair cell death among rats treated with JP-8 + noise for 5 days as compared to noise alone. In most instances, hydrocarbon constituents of the fuel were largely eliminated in all tissues by 1-h postexposure with the exception of fat. Finally, JP-8 exposure did result in a significant depletion of total GSH that was observable in liver with a nonsignificant trend toward depletion in the brain and lung raising the possibility that the promotion of noise-induced hearing loss by JP-8 might have resulted from oxidative stress. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Fechter, Laurence D AU - Gearhart, Caroline AU - Fulton, Sherry AU - Campbell, Jerry AU - Fisher, Jeffrey AU - Na, Kwangsam AU - Cocker, David AU - Nelson-Miller, Alisa AU - Moon, Patrick AU - Pouyatos, Benoit AD - Loma Linda VA Medical Center, Loma Linda, California 92357, USA. Larry.fechter@med.va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 510 EP - 525 VL - 98 IS - 2 SN - 1096-6080, 1096-6080 KW - Air Pollutants, Occupational KW - 0 KW - Hydrocarbons KW - JP8 aviation fuel KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Animals KW - Rats, Long-Evans KW - Auditory Threshold -- drug effects KW - Cochlea -- metabolism KW - Brain -- drug effects KW - Glutathione -- metabolism KW - Liver -- metabolism KW - Brain -- metabolism KW - Lung -- metabolism KW - Cochlea -- drug effects KW - Cochlea -- physiopathology KW - Hair Cells, Auditory, Outer -- drug effects KW - Rats KW - Adipose Tissue -- metabolism KW - Liver -- drug effects KW - Lung -- drug effects KW - Cochlea -- pathology KW - Male KW - Hair Cells, Auditory, Outer -- pathology KW - Hearing Loss, Noise-Induced -- pathology KW - Hydrocarbons -- analysis KW - Hearing Loss, Noise-Induced -- physiopathology KW - Hearing Loss, Noise-Induced -- etiology KW - Air Pollutants, Occupational -- analysis KW - Hydrocarbons -- pharmacokinetics KW - Hydrocarbons -- toxicity KW - Hydrocarbons -- blood KW - Air Pollutants, Occupational -- toxicity KW - Air Pollutants, Occupational -- pharmacokinetics KW - Air Pollutants, Occupational -- blood KW - Noise -- adverse effects KW - Hearing Loss, Noise-Induced -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70761230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=JP-8+jet+fuel+can+promote+auditory+impairment+resulting+from+subsequent+noise+exposure+in+rats.&rft.au=Fechter%2C+Laurence+D%3BGearhart%2C+Caroline%3BFulton%2C+Sherry%3BCampbell%2C+Jerry%3BFisher%2C+Jeffrey%3BNa%2C+Kwangsam%3BCocker%2C+David%3BNelson-Miller%2C+Alisa%3BMoon%2C+Patrick%3BPouyatos%2C+Benoit&rft.aulast=Fechter&rft.aufirst=Laurence&rft.date=2007-08-01&rft.volume=98&rft.issue=2&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-19 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Contact dermatitis of the hands: cross-sectional analyses of North American Contact Dermatitis Group Data, 1994-2004. AN - 70754975; 17553593 AB - Hand dermatitis, including irritant and allergic contact dermatitis (ACD), is common. To evaluate allergens, relevant irritants, sources and occupations associated with hand contact dermatitis using North American Contact Dermatitis Group (NACDG) data. A cross-sectional analysis of 22,025 patients patch tested between 1994 and 2004. Hand involvement was found in 6953 patients; 959 had ACD as the only diagnosis. In these 959 patients, the 12 most frequent relevant allergens were quaternium-15 (16.5%), formaldehyde (13.0%), nickel sulfate (12.2%), fragrance mix (11.3%), thiuram mix (10.2%), balsam of Peru (9.6%), carba mix (7.8%), neomycin sulfate (7.7%), bacitracin (7.4%), methyldibromoglutaronitrile/phenoxyethanol 2.0% (7.4%), cobalt chloride (6.5%), and methyldibromoglutaronitrile/phenoxyethanol 2.5% (6.3%). Rubber allergens were most commonly associated with occupation. One third of patients with hand ACD had identifiable relevant irritants. Cross-sectional analyses prevent evaluation of causal associations. In NACDG patients with hand ACD, the most common allergens included preservatives, metals, fragrances, topical antibiotics, and rubber additives. JF - Journal of the American Academy of Dermatology AU - Warshaw, Erin M AU - Ahmed, Rehana L AU - Belsito, Donald V AU - DeLeo, Vincent A AU - Fowler, Joseph F AU - Maibach, Howard I AU - Marks, James G AU - Toby Mathias, C G AU - Pratt, Melanie D AU - Rietschel, Robert L AU - Sasseville, Denis AU - Storrs, Frances J AU - Taylor, James S AU - Zug, Kathryn A AU - North American Contact Dermatitis Group AD - Department of Dermatology, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA. erin.warshaw@med.va.gov ; North American Contact Dermatitis Group Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 301 EP - 314 VL - 57 IS - 2 KW - Allergens KW - 0 KW - Anti-Bacterial Agents KW - Metals KW - Perfume KW - Preservatives, Pharmaceutical KW - Rubber KW - 9006-04-6 KW - Index Medicus KW - Occupational Exposure KW - Allergens -- immunology KW - Humans KW - Anti-Bacterial Agents -- adverse effects KW - Aged KW - Child KW - Child, Preschool KW - Infant KW - Cross-Sectional Studies KW - Metals -- adverse effects KW - Aged, 80 and over KW - Perfume -- adverse effects KW - Adult KW - Incidence KW - Anti-Bacterial Agents -- administration & dosage KW - Middle Aged KW - Adolescent KW - Preservatives, Pharmaceutical -- adverse effects KW - Male KW - Female KW - Administration, Topical KW - Dermatitis, Irritant -- etiology KW - Hand Dermatoses -- epidemiology KW - Dermatitis, Contact -- immunology KW - Hand Dermatoses -- immunology KW - Dermatitis, Contact -- etiology KW - Dermatitis, Contact -- epidemiology KW - Hand Dermatoses -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70754975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Contact+dermatitis+of+the+hands%3A+cross-sectional+analyses+of+North+American+Contact+Dermatitis+Group+Data%2C+1994-2004.&rft.au=Warshaw%2C+Erin+M%3BAhmed%2C+Rehana+L%3BBelsito%2C+Donald+V%3BDeLeo%2C+Vincent+A%3BFowler%2C+Joseph+F%3BMaibach%2C+Howard+I%3BMarks%2C+James+G%3BToby+Mathias%2C+C+G%3BPratt%2C+Melanie+D%3BRietschel%2C+Robert+L%3BSasseville%2C+Denis%3BStorrs%2C+Frances+J%3BTaylor%2C+James+S%3BZug%2C+Kathryn+A%3BNorth+American+Contact+Dermatitis+Group&rft.aulast=Warshaw&rft.aufirst=Erin&rft.date=2007-08-01&rft.volume=57&rft.issue=2&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=1097-6787&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-31 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Promotion of noise-induced cochlear injury by toluene and ethylbenzene in the rat. AN - 70736199; 17517824 AB - Ethylbenzene + toluene are known individually to have ototoxic potential at high exposure levels and with prolonged exposure times generally of 4-16 weeks. Both ethylbenzene + toluene are minor constituents of JP-8 jet fuel; this fuel has recently been determined to promote susceptibility to noise-induced hearing loss. Therefore, the current study evaluates the ototoxic potential of combined exposure to ethylbenzene + toluene exposure in a ratio calculated from the average found in three laboratories. Rats received ethylbenzene + toluene by inhalation and half of them were subjected simultaneously to an octave band of noise (OBN) of 93-95 dB. Another group received only the noise exposure which was designed to produce a small, but permanent auditory impairment while an unexposed control group was also included. In two separate experiments, exposures occurred either repeatedly on 5 successive days for 1 week or for 5 days on 2 successive weeks to 4000 mg/m(3) total hydrocarbons for 6 h based upon initial pilot studies. The concentration of toluene was 400 ppm and the concentration of ethylbenzene was 660 ppm. Impairments in auditory function were assessed using distortion product otoacoustic emissions and compound action potential testing. Following completion of these tests, the organs of Corti were dissected to permit evaluation of hair cell loss. The uptake and elimination of the solvents was assessed by harvesting key organs at two time points following ethylbenzene + toluene exposure from additional rats not used for auditory testing. Similarly, glutathione (GSH) levels were measured in light of suggestions that oxidative stress might result from solvent-noise exposures. Ethylbenzene + toluene exposure by itself at 4000 mg/m(3) for 6 h did not impair cochlear function or yield a loss of hair cells. However, when combined with a 93-dB OBN exposure combined solvent + noise did yield a loss in auditory function and a clear potentiation of outer hair cell death that exceeded the loss produced by noise alone. No evidence was found for a loss in total GSH in lung, liver, or brain as a consequence of ethylbenzene + toluene exposure. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Fechter, Laurence D AU - Gearhart, Caroline AU - Fulton, Sherry AU - Campbell, Jerry AU - Fisher, Jeffrey AU - Na, Kwangsam AU - Cocker, David AU - Nelson-Miller, Alisa AU - Moon, Patrick AU - Pouyatos, Benoit AD - Loma Linda VA Medical Center, Loma Linda, California 92357, USA. Larry.fechter@med.va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 542 EP - 551 VL - 98 IS - 2 SN - 1096-6080, 1096-6080 KW - Air Pollutants, Occupational KW - 0 KW - Benzene Derivatives KW - Solvents KW - Toluene KW - 3FPU23BG52 KW - Glutathione KW - GAN16C9B8O KW - ethylbenzene KW - L5I45M5G0O KW - Index Medicus KW - Animals KW - Rats, Long-Evans KW - Auditory Threshold -- drug effects KW - Cochlea -- metabolism KW - Brain -- drug effects KW - Glutathione -- metabolism KW - Liver -- metabolism KW - Brain -- metabolism KW - Lung -- metabolism KW - Cochlea -- drug effects KW - Cochlea -- physiopathology KW - Hair Cells, Auditory, Outer -- drug effects KW - Rats KW - Liver -- drug effects KW - Hair Cells, Auditory, Outer -- physiopathology KW - Lung -- drug effects KW - Cochlea -- pathology KW - Male KW - Hair Cells, Auditory, Outer -- pathology KW - Hearing Loss, Noise-Induced -- pathology KW - Solvents -- toxicity KW - Benzene Derivatives -- pharmacokinetics KW - Hearing Loss, Noise-Induced -- physiopathology KW - Toluene -- pharmacokinetics KW - Solvents -- pharmacokinetics KW - Toluene -- blood KW - Toluene -- toxicity KW - Air Pollutants, Occupational -- toxicity KW - Benzene Derivatives -- blood KW - Noise -- adverse effects KW - Hearing Loss, Noise-Induced -- metabolism KW - Benzene Derivatives -- toxicity KW - Hearing Loss, Noise-Induced -- etiology KW - Air Pollutants, Occupational -- blood KW - Air Pollutants, Occupational -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70736199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Promotion+of+noise-induced+cochlear+injury+by+toluene+and+ethylbenzene+in+the+rat.&rft.au=Fechter%2C+Laurence+D%3BGearhart%2C+Caroline%3BFulton%2C+Sherry%3BCampbell%2C+Jerry%3BFisher%2C+Jeffrey%3BNa%2C+Kwangsam%3BCocker%2C+David%3BNelson-Miller%2C+Alisa%3BMoon%2C+Patrick%3BPouyatos%2C+Benoit&rft.aulast=Fechter&rft.aufirst=Laurence&rft.date=2007-08-01&rft.volume=98&rft.issue=2&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-19 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Results of a randomized, double-blind, vehicle-controlled efficacy trial of pimecrolimus cream 1% for the treatment of moderate to severe facial seborrheic dermatitis. AN - 70731084; 17188780 AB - Seborrheic dermatitis is commonly treated with anti-inflammatory products, including topical corticosteroids. Pimecrolimus cream 1% also exerts anti-inflammatory activity by inhibiting T-cell cytokine production. We sought to compare the efficacy and safety of twice-daily pimecrolimus for treatment of moderate to severe facial seborrheic dermatitis. This double-blind, vehicle-controlled, 4-week trial randomized patients with seborrheic dermatitis to pimecrolimus or vehicle (1:1). Clinical assessments (erythema [0-3] and scaling [0-3] combined for a total area score [0-6]) were performed at weeks 0, 2, and 4. Inclusion criteria included total area score 4 or greater and erythema 2 or greater. The prespecified primary variable, change from baseline in total area score at week 4, was analyzed using a two-sample t test for intent-to-treat and per protocol populations. In all, 96 adults of mean age 59.6 years, 88.5% male, were randomized (n = 47 pimecrolimus; 49 vehicle). At week 4, the mean change from baseline in total area score was 3.7 versus 3.3 for pimecrolimus and vehicle groups, respectively (intent-to-treat: P = .1913; 95% confidence interval (CI) for difference [-0.195, 0.961]). Per protocol analysis (n = 41 pimecrolimus; 46 vehicle) indicated a significant difference between groups (mean change 3.9 pimecrolimus vs 3.2 vehicle; P = .0156; CI [0.129, 1.197]). The superiority of pimecrolimus was observed as early as week 2 (intent-to-treat: P = .0062; CI [0.132, 0.777]; per protocol: P = .0012; CI [0.410, 1.593]). No drug-related serious adverse events occurred. The most frequent drug-related adverse events were local, mild, and transient (pimecrolimus = 26%; vehicle = 12%). Generalizability is limited by the elderly male study population. This study suggests that pimecrolimus cream 1% is an effective and well-tolerated treatment for moderate to severe facial seborrheic dermatitis. JF - Journal of the American Academy of Dermatology AU - Warshaw, Erin M AU - Wohlhuter, Ross Jon AU - Liu, An AU - Zeller, Sarah A AU - Wenner, Rachel A AU - Bowers, Sacharitha AU - Schultz, Julie C AU - Katz, H Irving AU - McCormick, Calogera L AU - Parneix-Spake, Anne AD - Minneapolis Department of Veterans Affairs Medical Center, University of Minnesota, Minneapolis MN 55417, USA. Erin.Warshaw@med.va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 257 EP - 264 VL - 57 IS - 2 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - pimecrolimus KW - 7KYV510875 KW - Tacrolimus KW - WM0HAQ4WNM KW - Index Medicus KW - Severity of Illness Index KW - Drug Administration Schedule KW - Drug Eruptions -- etiology KW - Patient Satisfaction KW - Double-Blind Method KW - Aged, 80 and over KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Male KW - Female KW - Tacrolimus -- adverse effects KW - Tacrolimus -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Tacrolimus -- analogs & derivatives KW - Facial Dermatoses -- pathology KW - Anti-Inflammatory Agents, Non-Steroidal -- administration & dosage KW - Tacrolimus -- administration & dosage KW - Facial Dermatoses -- drug therapy KW - Dermatitis, Seborrheic -- drug therapy KW - Dermatitis, Seborrheic -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70731084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Results+of+a+randomized%2C+double-blind%2C+vehicle-controlled+efficacy+trial+of+pimecrolimus+cream+1%25+for+the+treatment+of+moderate+to+severe+facial+seborrheic+dermatitis.&rft.au=Warshaw%2C+Erin+M%3BWohlhuter%2C+Ross+Jon%3BLiu%2C+An%3BZeller%2C+Sarah+A%3BWenner%2C+Rachel+A%3BBowers%2C+Sacharitha%3BSchultz%2C+Julie+C%3BKatz%2C+H+Irving%3BMcCormick%2C+Calogera+L%3BParneix-Spake%2C+Anne&rft.aulast=Warshaw&rft.aufirst=Erin&rft.date=2007-08-01&rft.volume=57&rft.issue=2&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=1097-6787&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-31 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam/amoxicillin-clavulanate. AN - 70717183; 17553812 AB - Complicated skin and skin structure infections (cSSSIs), including diabetic foot infections (DFIs), are often polymicrobial, requiring combination or broad-spectrum therapy. Moxifloxacin, a broad-spectrum fluoroquinolone, is approved for cSSSI and can be administered by either intravenous (iv) or oral routes. To assess the efficacy of moxifloxacin for treating DFIs, we analysed a subset of patients with these infections who were enrolled in a prospective, double-blind study that compared the efficacy of moxifloxacin with piperacillin-tazobactam and amoxicillin-clavulanate. Patients>or=18 years of age with a DFI requiring initial iv therapy were randomized to either moxifloxacin (400 mg/day) or piperacillin-tazobactam (3.0/0.375 g every 6 h) for at least 3 days followed by moxifloxacin (400 mg/day orally) or amoxicillin-clavulanate (800 mg every 12 h orally), if appropriate, for 7-14 days. DFI was usually defined as any foot infection plus a history of diabetes. Our primary efficacy outcome was the clinical response of the infection at test-of-cure (TOC), 10-42 days post-therapy. Among 617 patients enrolled in the original study, 78 with DFIs were evaluable for treatment efficacy. Clinical cure rates at TOC were similar for moxifloxacin and piperacillin-tazobactam/amoxicillin-clavulanate (68% versus 61%) for patients with investigator-defined infection (P=0.54). Overall pathogen eradication rates in the microbiologically-valid population were 69% versus 66% for moxifloxacin and comparator, respectively (P=1.00). Intravenous+/-oral moxifloxacin was as effective as iv piperacillin-tazobactam+/-amoxicillin-clavulanate in treating moderate-to-severe DFIs. Moxifloxacin may have potential as a monotherapy regimen for DFIs. JF - The Journal of antimicrobial chemotherapy AU - Lipsky, Benjamin A AU - Giordano, Philip AU - Choudhri, Shurjeel AU - Song, James AD - VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA. benjamin.lipsky@med.va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 370 EP - 376 VL - 60 IS - 2 SN - 0305-7453, 0305-7453 KW - Anti-Bacterial Agents KW - 0 KW - Aza Compounds KW - Fluoroquinolones KW - Quinolines KW - Amoxicillin-Potassium Clavulanate Combination KW - 74469-00-4 KW - Penicillanic Acid KW - 87-53-6 KW - tazobactam KW - SE10G96M8W KW - moxifloxacin KW - U188XYD42P KW - Piperacillin KW - X00B0D5O0E KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Databases, Factual KW - Aged KW - Male KW - Female KW - Anti-Bacterial Agents -- therapeutic use KW - Bacterial Infections -- microbiology KW - Quinolines -- therapeutic use KW - Amoxicillin-Potassium Clavulanate Combination -- therapeutic use KW - Diabetic Foot -- drug therapy KW - Anti-Bacterial Agents -- adverse effects KW - Diabetic Foot -- microbiology KW - Quinolines -- adverse effects KW - Amoxicillin-Potassium Clavulanate Combination -- adverse effects KW - Aza Compounds -- therapeutic use KW - Penicillanic Acid -- analogs & derivatives KW - Piperacillin -- adverse effects KW - Piperacillin -- therapeutic use KW - Bacterial Infections -- surgery KW - Penicillanic Acid -- adverse effects KW - Aza Compounds -- adverse effects KW - Penicillanic Acid -- therapeutic use KW - Bacterial Infections -- drug therapy KW - Diabetic Foot -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70717183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+antimicrobial+chemotherapy&rft.atitle=Treating+diabetic+foot+infections+with+sequential+intravenous+to+oral+moxifloxacin+compared+with+piperacillin-tazobactam%2Famoxicillin-clavulanate.&rft.au=Lipsky%2C+Benjamin+A%3BGiordano%2C+Philip%3BChoudhri%2C+Shurjeel%3BSong%2C+James&rft.aulast=Lipsky&rft.aufirst=Benjamin&rft.date=2007-08-01&rft.volume=60&rft.issue=2&rft.spage=370&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+antimicrobial+chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-30 N1 - Date created - 2007-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Update in addiction medicine for the generalist. AN - 70705844; 17492327 JF - Journal of general internal medicine AU - Gordon, Adam J AU - Sullivan, Lynn E AU - Alford, Daniel P AU - Arnsten, Julia H AU - Gourevitch, Marc N AU - Kertesz, Stefan G AU - Kunins, Hillary V AU - Merrill, Joseph O AU - Samet, Jeffrey H AU - Fiellin, David A AD - Mental Illness Research, Education, and Clinical Center, University of Pittsburgh, Pittsburgh, PA, USA. adam.gordon@va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1190 EP - 1194 VL - 22 IS - 8 KW - Index Medicus KW - Tobacco Use Disorder -- therapy KW - Humans KW - Alcoholism -- therapy KW - Opioid-Related Disorders -- therapy KW - Substance-Related Disorders -- therapy KW - Physicians, Family UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70705844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+general+internal+medicine&rft.atitle=Update+in+addiction+medicine+for+the+generalist.&rft.au=Gordon%2C+Adam+J%3BSullivan%2C+Lynn+E%3BAlford%2C+Daniel+P%3BArnsten%2C+Julia+H%3BGourevitch%2C+Marc+N%3BKertesz%2C+Stefan+G%3BKunins%2C+Hillary+V%3BMerrill%2C+Joseph+O%3BSamet%2C+Jeffrey+H%3BFiellin%2C+David+A&rft.aulast=Gordon&rft.aufirst=Adam&rft.date=2007-08-01&rft.volume=22&rft.issue=8&rft.spage=1190&rft.isbn=&rft.btitle=&rft.title=Journal+of+general+internal+medicine&rft.issn=1525-1497&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-03 N1 - Date created - 2007-07-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Fam Pract. 2001 Apr;50(4):321-2 [11300983] J Stud Alcohol Suppl. 2005 Jul;(15):170-8; discussion 168-9 [16223068] Lancet. 2002 Jul 6;360(9326):7-22 [12114036] Psychol Med. 2005 Dec;35(12):1747-59 [16202187] JAMA. 2006 May 3;295(17):2003-17 [16670409] Addiction. 2006 Jul;101(7):918-32 [16771885] JAMA. 2006 Jul 5;296(1):47-55 [16820546] JAMA. 2006 Jul 5;296(1):56-63 [16820547] JAMA. 2006 Jul 5;296(1):64-71 [16820548] Am Fam Physician. 2002 Jul 15;66(2):209 [12152956] Circulation. 2002 Dec 17;106(25):3143-421 [12485966] N Engl J Med. 2003 Jun 26;348(26):2635-45 [12826639] Cochrane Database Syst Rev. 2004;(1):CD003041 [14974003] JAMA. 2004 Mar 10;291(10):1238-45 [15010446] Ann Intern Med. 2004 Apr 6;140(7):557-68 [15068985] Drug Alcohol Depend. 2004 Jun 11;74(3):223-34 [15194200] Circulation. 2004 Jul 13;110(2):227-39 [15249516] J Pain Symptom Manage. 2004 Aug;28(2):176-88 [15276196] Lancet. 1990 Apr 7;335(8693):827-38 [1969567] Epidemiology. 1993 Jul;4(4):295-302 [8347739] MMWR Morb Mortal Wkly Rep. 1997 May 23;46(20):444-51 [9182206] JAMA. 1998 Feb 25;279(8):604-8 [9486755] J Fam Pract. 1998 Apr;46(4):328-35 [9564375] J Epidemiol Community Health. 1998 Jun;52(6):377-84 [9764259] N Engl J Med. 2005 Feb 10;352(6):596-607 [15703424] JAMA. 2000 Jun 28;283(24):3244-54 [10866874] J Fam Pract. 2001 Apr;50(4):307-12 [11300981] J Fam Pract. 2001 Apr;50(4):313-20 [11300982] JAMA. 2005 Apr 6;293(13):1617-25 [15811981] Alcohol Alcohol. 2005 May-Jun;40(3):208-13 [15797883] Arch Intern Med. 2005 Aug 8-22;165(15):1769-76 [16087826] J Stud Alcohol. 2001 Mar;62(2):211-20 [11327187] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Convergent validity of the Timeline Followback for persons with comorbid psychiatric disorders engaged in residential substance use treatment. AN - 70545917; 17254716 AB - This study examined the convergent validity of the Timeline Followback (TLFB) for individuals with comorbid (Axis I and/or Axis II) psychiatric disorders in a sample of persons (N=150) engaged in residential treatment for substance use disorders (SUDs). Approximately one-half of the sample was diagnosed with at least one comorbid psychiatric disorder. Validity was assessed comparing data from the TLFB with data from the Addiction Severity Index (ASI) and collateral reports. For the entire sample, data from the TLFB was significantly correlated with data from the ASI and collateral reports of substance use. No significant differences were found between those with and those without a comorbid psychiatric disorder, suggesting that the TLFB was equally valid for both groups. JF - Addictive behaviors AU - DeMarce, Josephine M AU - Burden, Jennifer L AU - Lash, Steven J AU - Stephens, Robert S AU - Grambow, Steven C AD - Veterans Affairs Medical Center, Salem, Virginia, 1970 Roanoke Blvd, Psychology (116A4), Salem, VA 24153, USA. josephine.demarce@va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1582 EP - 1592 VL - 32 IS - 8 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Humans KW - Surveys and Questionnaires KW - Middle Aged KW - Male KW - Female KW - Comorbidity KW - Bipolar Disorder -- diagnosis KW - Substance-Related Disorders -- diagnosis KW - Residential Treatment KW - Bipolar Disorder -- epidemiology KW - Anxiety -- diagnosis KW - Depression -- epidemiology KW - Anxiety -- epidemiology KW - Schizophrenia -- diagnosis KW - Depression -- diagnosis KW - Schizophrenia -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70545917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Convergent+validity+of+the+Timeline+Followback+for+persons+with+comorbid+psychiatric+disorders+engaged+in+residential+substance+use+treatment.&rft.au=DeMarce%2C+Josephine+M%3BBurden%2C+Jennifer+L%3BLash%2C+Steven+J%3BStephens%2C+Robert+S%3BGrambow%2C+Steven+C&rft.aulast=DeMarce&rft.aufirst=Josephine&rft.date=2007-08-01&rft.volume=32&rft.issue=8&rft.spage=1582&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-17 N1 - Date created - 2007-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Precipitants of first substance use in recently abstinent substance use disorder patients with PTSD. AN - 70545869; 17188816 AB - Patients with substance use (SUD) and posttraumatic stress disorders (PTSD) are at high risk for relapse. This study examined the reasons patients identify for their first substance use following discharge from SUD treatment. A total of 65 patients with and without PTSD completed clinical interviews, including an adapted version of the Relapse Interview [RI; Miller, W.R., & Marlatt, G.A. (1996). Appendix A: Relapse Interview. Addiction, 91(Suppl), 231-240.] at a 6-month follow-up. Qualitative data from the RI was consensus coded using Marlatt's taxonomy of relapse situations. Results indicated that patients with PTSD were less likely to report first substance use triggered by cue-based urges and more likely to report use in response to negative emotions of an interpersonal nature than those patients without PTSD. Other characteristics of first use associated with PTSD included greater subjective urges right before using, greater efforts to obtain substances and more likelihood to use to intoxication. Patients with unremitted PTSD reported poorer outcome and self-efficacy expectations than those without PTSD or with remitted PTSD. Implications for self-medication theory and clinical practice are discussed. JF - Addictive behaviors AU - Ouimette, Paige AU - Coolhart, Deborah AU - Funderburk, Jennifer Schum AU - Wade, Michael AU - Brown, Pamela J AD - Center for Integrated Healthcare, Syracuse VA Medical Center, and SUNY Upstate Medical University, Syracuse, NY, United States. paigec.ouimette@med.va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1719 EP - 1727 VL - 32 IS - 8 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Demography KW - Factor Analysis, Statistical KW - Age of Onset KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Incidence KW - Follow-Up Studies KW - Recurrence KW - Male KW - Female KW - Prevalence KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Life Change Events KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70545869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Precipitants+of+first+substance+use+in+recently+abstinent+substance+use+disorder+patients+with+PTSD.&rft.au=Ouimette%2C+Paige%3BCoolhart%2C+Deborah%3BFunderburk%2C+Jennifer+Schum%3BWade%2C+Michael%3BBrown%2C+Pamela+J&rft.aulast=Ouimette&rft.aufirst=Paige&rft.date=2007-08-01&rft.volume=32&rft.issue=8&rft.spage=1719&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-17 N1 - Date created - 2007-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of behavioral contingency management intervention on coping behaviors and PTSD symptom reduction in cocaine-addicted homeless. AN - 68257720; 17721968 AB - The purpose of this study was to examine changes in posttrauma symptoms among 118 homeless cocaine-dependent adults participating in a randomly controlled trial studying effective treatments for dually diagnosed homeless individuals. Among those with trauma exposure and PTSD symptoms, the group receiving more behaviorally intensive, contingency management treatment had significantly greater reductions in PTSD symptomatology than did the group receiving less-intensive treatment. Regression analyses revealed that greater positive distraction coping and lower negative avoidance coping at baseline, in addition to changes in avoidance coping over the 6-month study period, were significantly related to greater symptom and severity reductions. The study provides some initial evidence of important treatment outcomes other than abstinence in addiction-related interventions. JF - Journal of traumatic stress AU - Lester, Kristin M AU - Milby, Jesse B AU - Schumacher, Joseph E AU - Vuchinich, Rudolph AU - Person, Sharina AU - Clay, Olivio J AD - Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA. kristin.lester@va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 565 EP - 575 VL - 20 IS - 4 SN - 0894-9867, 0894-9867 KW - Index Medicus KW - Goals KW - Mental Disorders -- rehabilitation KW - Combined Modality Therapy KW - Humans KW - Rehabilitation, Vocational KW - Diagnosis, Dual (Psychiatry) KW - Mental Disorders -- psychology KW - Comorbidity KW - Mental Disorders -- diagnosis KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Day Care, Medical KW - Female KW - Male KW - Cocaine-Related Disorders -- diagnosis KW - Stress Disorders, Post-Traumatic -- rehabilitation KW - Token Economy KW - Stress Disorders, Post-Traumatic -- psychology KW - Adaptation, Psychological KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Cocaine-Related Disorders -- psychology KW - Homeless Persons -- psychology KW - Behavior Therapy -- methods KW - Cocaine-Related Disorders -- rehabilitation KW - Cognitive Therapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68257720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+traumatic+stress&rft.atitle=Impact+of+behavioral+contingency+management+intervention+on+coping+behaviors+and+PTSD+symptom+reduction+in+cocaine-addicted+homeless.&rft.au=Lester%2C+Kristin+M%3BMilby%2C+Jesse+B%3BSchumacher%2C+Joseph+E%3BVuchinich%2C+Rudolph%3BPerson%2C+Sharina%3BClay%2C+Olivio+J&rft.aulast=Lester&rft.aufirst=Kristin&rft.date=2007-08-01&rft.volume=20&rft.issue=4&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Journal+of+traumatic+stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-30 N1 - Date created - 2007-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Management of ileostomy trauma produced by a dog bite in a patient with thoracic paraplegia. AN - 68253004; 17826522 AB - Urologic trauma produced by dog bites is uncommon. Several previous single reports and small case series have described the treatment of dog bite-induced injuries to the external genitalia. In this report, we describe our treatment of a patient with thoracic paraplegia and an ileal conduit who had extensive trauma to his ileostomy as a result of a bite by the family dog. To our knowledge, the current case is the first report of dog bite-induced ileostomy trauma. JF - Urology AU - Pagel, Paul S AU - Scott, John P AU - Schmeling, William T AU - Donnell, Robert F AD - Department of Anesthesiology, Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295, USA. paul.pagel@va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 373.e8 EP - 9 VL - 70 IS - 2 KW - Index Medicus KW - Animals KW - Humans KW - Paraplegia KW - Dogs KW - Ileostomy KW - Bites and Stings UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68253004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urology&rft.atitle=Management+of+ileostomy+trauma+produced+by+a+dog+bite+in+a+patient+with+thoracic+paraplegia.&rft.au=Pagel%2C+Paul+S%3BScott%2C+John+P%3BSchmeling%2C+William+T%3BDonnell%2C+Robert+F&rft.aulast=Pagel&rft.aufirst=Paul&rft.date=2007-08-01&rft.volume=70&rft.issue=2&rft.spage=373.e8&rft.isbn=&rft.btitle=&rft.title=Urology&rft.issn=1527-9995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-03 N1 - Date created - 2007-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Emerging issues in the management of infections caused by multidrug-resistant gram-negative bacteria. AN - 68252225; 17847174 AB - Accumulating evidence indicates that treating seriously ill infected patients with active antibiotics early in the course of infection is critical to improving outcomes. The most common reason for ineffective empiric therapy is resistance to the agents used. Gram-negative bacteria are becoming increasingly resistant to many commonly used antibiotics, and some cases require older, more toxic antibiotics for adequate microbial coverage. The diversity of resistance mechanisms that underly multidrug resistance makes developing effective new antimicrobial agents very difficult, especially against problematic species such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. This growing problem requires a multipronged strategy that includes adherence to infection control principles, parsimonious and rational use of current antimicrobial agents, and development of new agents active against multidrug-resistant pathogens. JF - Cleveland Clinic journal of medicine AU - Rice, Louis B AD - Louis Stokes Cleveland VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. louis.rice@med.va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - S12 EP - S20 VL - 74 Suppl 4 SN - 0891-1150, 0891-1150 KW - Anti-Bacterial Agents KW - 0 KW - Porins KW - Index Medicus KW - Anti-Bacterial Agents -- therapeutic use KW - beta-Lactam Resistance -- genetics KW - Klebsiella pneumoniae -- drug effects KW - Humans KW - Anti-Bacterial Agents -- pharmacology KW - Pseudomonas aeruginosa -- drug effects KW - Acinetobacter baumannii -- drug effects KW - Hospitals KW - Infection Control -- standards KW - Infection Control -- methods KW - Drug Resistance, Multiple, Bacterial -- genetics KW - Gram-Negative Bacterial Infections -- drug therapy KW - Gram-Negative Bacterial Infections -- microbiology KW - Cross Infection -- microbiology KW - Cross Infection -- epidemiology KW - Gram-Negative Bacterial Infections -- prevention & control KW - Gram-Negative Bacteria -- isolation & purification KW - Gram-Negative Bacteria -- drug effects KW - Cross Infection -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68252225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cleveland+Clinic+journal+of+medicine&rft.atitle=Emerging+issues+in+the+management+of+infections+caused+by+multidrug-resistant+gram-negative+bacteria.&rft.au=Rice%2C+Louis+B&rft.aulast=Rice&rft.aufirst=Louis&rft.date=2007-08-01&rft.volume=74+Suppl+4&rft.issue=&rft.spage=S12&rft.isbn=&rft.btitle=&rft.title=Cleveland+Clinic+journal+of+medicine&rft.issn=08911150&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-31 N1 - Date created - 2007-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Additional evidence of the abuse potential of quetiapine. AN - 68191691; 17713313 AB - Quetiapine is an atypical antipsychotic agent approved by the FDA for the treatment of schizophrenia, acute mania, and bipolar depression. Recently, reports of medication abuse, particularly intranasal and i.v. abuse, have been described. Three cases of oral misuse of quetiapine are presented and clinical implications are discussed. Clinicians should exercise caution when prescribing quetiapine to patients at risk for substance abuse. JF - Southern medical journal AU - Reeves, Roy R AU - Brister, James C AD - G.V. (Sonny) Montgomery VA Medical Center, Jackson, Mississippi, USA. roy.reeves@med.va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 834 EP - 836 VL - 100 IS - 8 SN - 0038-4348, 0038-4348 KW - Antipsychotic Agents KW - 0 KW - Dibenzothiazepines KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Bipolar Disorder -- drug therapy KW - Adult KW - Middle Aged KW - Male KW - Antipsychotic Agents -- administration & dosage KW - Dibenzothiazepines -- adverse effects KW - Substance-Related Disorders -- etiology KW - Antipsychotic Agents -- adverse effects KW - Dibenzothiazepines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68191691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Additional+evidence+of+the+abuse+potential+of+quetiapine.&rft.au=Reeves%2C+Roy+R%3BBrister%2C+James+C&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2007-08-01&rft.volume=100&rft.issue=8&rft.spage=834&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-25 N1 - Date created - 2007-08-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Posttraumatic stress disorder symptoms, physiological reactivity, alcohol problems, and aggression among military veterans. AN - 68164672; 17696706 AB - This study examined the association between posttraumatic stress disorder (PTSD) symptomatology and aggressive behavior among a sample of male Vietnam veterans (N = 1,328). Results indicated that the hyperarousal PTSD symptom cluster evidenced the strongest positive association with aggression at the bivariate level when compared with the other PTSD symptom clusters. When the PTSD symptom clusters were examined together as predictors, hyperarousal symptoms evidenced a significant positive relationship with aggression, and avoidance/numbing symptoms were negatively associated with aggression. Examination of potential mediators indicated that hyperarousal symptoms were directly associated with aggression and indirectly related to aggression via alcohol problems. Reexperiencing symptoms were associated with aggression only indirectly and through their positive association with physiological reactivity and negative association with alcohol problems. Study results highlight the complexity of the relationship between PTSD symptoms and aggression, and suggest possible mechanisms explaining this association. (c) 2007 APA, all rights reserved JF - Journal of abnormal psychology AU - Taft, Casey T AU - Kaloupek, Danny G AU - Schumm, Jeremiah A AU - Marshall, Amy D AU - Panuzio, Jillian AU - King, Daniel W AU - Keane, Terence M AD - National Center for PTSD, Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA. casey.taft@va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 498 EP - 507 VL - 116 IS - 3 SN - 0021-843X, 0021-843X KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Female KW - Prevalence KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Veterans -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Stress Disorders, Post-Traumatic -- psychology KW - Aggression -- psychology KW - Military Personnel -- psychology KW - Veterans -- psychology KW - Arousal -- physiology KW - Military Personnel -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68164672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+abnormal+psychology&rft.atitle=Posttraumatic+stress+disorder+symptoms%2C+physiological+reactivity%2C+alcohol+problems%2C+and+aggression+among+military+veterans.&rft.au=Taft%2C+Casey+T%3BKaloupek%2C+Danny+G%3BSchumm%2C+Jeremiah+A%3BMarshall%2C+Amy+D%3BPanuzio%2C+Jillian%3BKing%2C+Daniel+W%3BKeane%2C+Terence+M&rft.aulast=Taft&rft.aufirst=Casey&rft.date=2007-08-01&rft.volume=116&rft.issue=3&rft.spage=498&rft.isbn=&rft.btitle=&rft.title=Journal+of+abnormal+psychology&rft.issn=0021843X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-01 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A longitudinal study of personality and major depression in a population-based sample of male twins AN - 57241102; 200809936 AB - Background. The relationship between personality and psychiatric illness is complex. It is not clear whether one directly causes the other. Method. In a population-based sample of male twins (n = 3030), we attempted to predict major depression (MD) from neuroticism (N) and extraversion (E) and vice versa, to evaluate the causal, scar, state, and prodromal hypotheses. In a longitudinal, structural equation twin model, we decomposed the covariation between N and MD into (a) genetic and environmental factors that are common to both traits, as well as specific to each one and (b) direct causal effects of N at time 1 on subsequent MD, as well as between MD and subsequent N. Results. E was negatively correlated with lifetime and one-year prevalence of MD. N predicted the new onset of MD, and was predicted by both current and past MD. It did not predict the time to onset of MD. All of the covariation between N and MD was due to additive genetic and individual-specific environmental factors shared by both traits and a direct causal path between MD and N assessed later. No genetic factors were unique to either trait. Conclusions. In men, N may be a vulnerability factor for MD but does not cause it directly. However, MD may have a direct causal effect on N. The genetic overlap between N and MD in men may be greater than in women. Adapted from the source document. JF - Psychological Medicine AU - Fanous, Ayman H AU - Neale, Michael C AU - Aggen, Steven H AU - Kendler, Kenneth S AD - Washington VA Medical Center, 50 Irving St NW, Washington, DC 20422, USA ayman.fanous@med.va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1163 EP - 1172 PB - Cambridge University Press, UK VL - 37 IS - 8 SN - 0033-2917, 0033-2917 KW - Genetic factors KW - Depression KW - Neuroticism KW - Extraversion KW - Gender differences KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57241102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=A+longitudinal+study+of+personality+and+major+depression+in+a+population-based+sample+of+male+twins&rft.au=Fanous%2C+Ayman+H%3BNeale%2C+Michael+C%3BAggen%2C+Steven+H%3BKendler%2C+Kenneth+S&rft.aulast=Fanous&rft.aufirst=Ayman&rft.date=2007-08-01&rft.volume=37&rft.issue=8&rft.spage=1163&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291707000244 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Depression; Neuroticism; Gender differences; Genetic factors; Extraversion DO - http://dx.doi.org/10.1017/S0033291707000244 ER - TY - JOUR T1 - Hippocampal volume in aging combat veterans with and without post-traumatic stress disorder: Relation to risk and resilience factors AN - 57219454; 200716413 AB - Objective: To examine whether there are post-traumatic stress disorder (PTSD) related differences in hippocampal volume in middle-aged and elderly veterans and to examine the relationship of neuroendocrine activity, memory performance, and measures risk and resilience for PTSD to hippocampal volume in this cohort. Methods: Seventeen veterans with chronic PTSD and 16 veterans without chronic PTSD received an MRI scan followed by neuroendocrine assessment (24-h urinary cortisol excretion and the lysozyme IC50-DEX, a measure of glucocorticoid receptor (GR) responsiveness), and cognitive testing. Results: Veterans with PTSD did not differ from those without PTSD in hippocampal volume, but they did show significantly lower urinary cortisol levels, and poorer memory performance on the Wechsler Logical Memory test and Digit Span test. Smaller left hippocampal volumes were observed in veterans who developed PTSD in response to their first reported traumatic exposure, compared to veterans who had first experienced a traumatic event to which they did not develop PTSD, prior to experiencing a subsequent event that led to PTSD. In contrast, the two neuroendocrine measures were associated with risk factors related to early trauma exposure. Conclusion: Although hippocampal volume was not found to differ between subjects with and without PTSD, smaller hippocampal volumes in PTSD may be associated with specific risk and resilience factors. These may be distinct from vulnerability markers associated with increased responsiveness to glucocorticoids and/or other neuroendocrine measures that have been observed in combat-related PTSD. [Copyright 2005 Elsevier Ltd.] JF - Journal of Psychiatric Research AU - Yehuda, Rachel AU - Golier, Julia A AU - Tischler, Lisa AU - Harvey, Philip D AU - Newmark, Randall AU - Yang, Ren Kui AU - Buchsbaum, Monte S AD - Bronx VA OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, United States. Tel.: +1 718 584 9000x6964 E-mail: Rachel.Yehuda@med.va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 435 EP - 445 PB - Elsevier Ltd, Oxford UK VL - 41 IS - 5 SN - 0022-3956, 0022-3956 KW - Hippocampus, Memory performance, Cortisol, Glucocorticoid receptors, Post-traumatic stress diorder, Risk, Resilience KW - Veterans KW - Memory KW - Posttraumatic stress disorder KW - Hippocampus KW - Neuroendocrine response KW - Urinary cortisol KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57219454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychiatric+Research&rft.atitle=Hippocampal+volume+in+aging+combat+veterans+with+and+without+post-traumatic+stress+disorder%3A+Relation+to+risk+and+resilience+factors&rft.au=Yehuda%2C+Rachel%3BGolier%2C+Julia+A%3BTischler%2C+Lisa%3BHarvey%2C+Philip+D%3BNewmark%2C+Randall%3BYang%2C+Ren+Kui%3BBuchsbaum%2C+Monte+S&rft.aulast=Yehuda&rft.aufirst=Rachel&rft.date=2007-08-01&rft.volume=41&rft.issue=5&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychiatric+Research&rft.issn=00223956&rft_id=info:doi/10.1016%2Fj.jpsychires.2005.12.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-08-28 N1 - Last updated - 2016-09-27 N1 - CODEN - JPYRA3 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Veterans; Urinary cortisol; Hippocampus; Memory; Neuroendocrine response DO - http://dx.doi.org/10.1016/j.jpsychires.2005.12.002 ER - TY - JOUR T1 - The role of attentional biases in PTSD: Is it interference or facilitation? AN - 57204665; 200807908 AB - Although attentional biases have been demonstrated in individuals with posttraumatic stress disorder (PTSD), the cognitive methodologies used have not allowed for disambiguation of two types of attentional biases. It remains unclear if PTSD involves difficulty disengaging attention from threatening stimuli (interference) or facilitated detection. To differentiate between attentional interference and facilitation, 57 male Vietnam-era veterans (30 High PTSD and 27 Low PTSD) completed a visual search task with a lexical decision component. High PTSD veterans who engaged in the interference task first showed increased interference to threat-relevant words relative to Low PTSD veterans. However, no evidence was found for facilitated detection of threatening stimuli in PTSD. [Copyright 2007 Elsevier Ltd.] JF - Behaviour Research and Therapy AU - Pineles, Suzanne L AU - Shipherd, Jillian C AU - Welch, Lisa P AU - Yovel, Iftah AD - VA Boston Healthcare System, National Center for PTSD, Women's Health Sciences Division (116B-3), Boston, MA, USA suzanne.pineles@va.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1903 EP - 1913 PB - Elsevier, Amsterdam The Netherlands VL - 45 IS - 8 SN - 0005-7967, 0005-7967 KW - Posttraumatic stress disorder KW - Attentional bias KW - Attentional interference KW - Attentional facilitation KW - Threats KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57204665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behaviour+Research+and+Therapy&rft.atitle=The+role+of+attentional+biases+in+PTSD%3A+Is+it+interference+or+facilitation%3F&rft.au=Pineles%2C+Suzanne+L%3BShipherd%2C+Jillian+C%3BWelch%2C+Lisa+P%3BYovel%2C+Iftah&rft.aulast=Pineles&rft.aufirst=Suzanne&rft.date=2007-08-01&rft.volume=45&rft.issue=8&rft.spage=1903&rft.isbn=&rft.btitle=&rft.title=Behaviour+Research+and+Therapy&rft.issn=00057967&rft_id=info:doi/10.1016%2Fj.brat.2006.08.021 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - BRTHAA N1 - SubjectsTermNotLitGenreText - Attentional bias; Threats; Posttraumatic stress disorder DO - http://dx.doi.org/10.1016/j.brat.2006.08.021 ER - TY - JOUR T1 - Chronic ethanol ingestion increases nitric oxide production in the lung AN - 21060841; 8602061 AB - Chronic ethanol (EtOH) ingestion increases the incidence of acute respiratory distress syndrome. The mechanisms underlying EtOH-induced susceptibility to lung injury continue to be defined. This study examines the hypothesis that EtOH increases endothelial nitric oxide synthase (eNOS) expression and activity in the lungs of a rat model of chronic EtOH ingestion. Male Sprague-Dawley rats were fed liquid diets containing EtOH (36% of calories) or maltose-dextrin as an isocaloric substitution for EtOH (control) for 6 weeks. Selected animals were also treated with the angiotensin-converting enzyme (ACE) inhibitor lisinopril (3 mg/l in diet) for 6 weeks. At study completion, animals were sacrificed, and lung tissue was collected for assays of nitric oxide (NO) metabolism or pulmonary microvascular endothelial cells (MVEC) were isolated for analysis of NO release. Compared to the control diet, chronic EtOH ingestion increased lung H sub(2)O sub(2) production, eNOS expression and activity, lung cyclic guanosine monophosphate (cGMP) content, and levels of protein nitration and oxidation. MVEC from animals with chronic EtOH ingestion released greater amounts of NO. EtOH-induced increases in lung H sub(2)O sub(2) production, eNOS expression and activity, cGMP content, protein nitration and oxidation, and MVEC NO production were all attenuated by treatment with lisinopril. Chronic EtOH ingestion stimulates ACE-dependent increases in NO production in the lung. These novel findings indicate that chronic EtOH ingestion increases reactive species production in the lung parenchyma and provide new insights into mechanisms by which EtOH causes phenotypic alterations in the lung and alters the lung's response to inflammatory stimuli. JF - Alcohol AU - Polikandriotis, John A AU - Rupnow, Heidi L AU - Brown, Lou Ann AU - Hart, CMichael AD - Department of Medicine, Atlanta Veterans Affairs, Emory University Medical Center, Atlanta, GA 30033, USA, michael.hart3@va.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 309 EP - 316 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 41 IS - 5 SN - 0741-8329, 0741-8329 KW - Toxicology Abstracts KW - Alcohol KW - Nitric oxide KW - Nitric oxide synthase KW - Diets KW - Peptidyl-dipeptidase A KW - Parenchyma KW - Microvasculature KW - Calories KW - Injuries KW - Animal models KW - Inflammation KW - Nitric-oxide synthase KW - Endothelial cells KW - Cyclic GMP KW - Hydrogen peroxide KW - Lung KW - Oxidation KW - Nitration KW - Respiratory distress syndrome KW - Metabolism KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21060841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol&rft.atitle=Chronic+ethanol+ingestion+increases+nitric+oxide+production+in+the+lung&rft.au=Polikandriotis%2C+John+A%3BRupnow%2C+Heidi+L%3BBrown%2C+Lou+Ann%3BHart%2C+CMichael&rft.aulast=Polikandriotis&rft.aufirst=John&rft.date=2007-08-01&rft.volume=41&rft.issue=5&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/10.1016%2Fj.alcohol.2007.03.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Parenchyma; Peptidyl-dipeptidase A; Diets; Microvasculature; Calories; Injuries; Animal models; Inflammation; Cyclic GMP; Endothelial cells; Nitric-oxide synthase; Lung; Hydrogen peroxide; Oxidation; Nitration; Respiratory distress syndrome; Nitric oxide; Metabolism; Ethanol DO - http://dx.doi.org/10.1016/j.alcohol.2007.03.012 ER - TY - JOUR T1 - Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo AN - 20143237; 7559635 AB - Chemopreventive agents in colorectal cancer possess either antiproliferative or anti-inflammatory actions. Nonsteroidal anti-inflammatory drugs (NSAID) and cyclooxygenase-2 inhibitors have shown promise, but are compromised by side effects. Nitric oxide donor NSAIDs are organic nitrates conjugated via a labile linker to an NSAID, originally designed for use in pain relief, that have shown efficacy in colorectal cancer chemoprevention. The NO chimera, GT-094, is a novel nitrate containing an NSAID and disulfide pharmacophores, a lead compound for the design of agents specifically for colorectal cancer. GT-094 is the first nitrate reported to reduce aberrant crypt foci (by 45%) when administered after carcinogen in the standard azoxymethane rat model of colorectal cancer. Analysis of proximal and distal colon tissue from 8- and 28-week rat/azoxymethane studies showed that GT-094 treatment reduced colon crypt proliferation by 30% to 69%, reduced inducible NO synthase (iNOS) levels by 33% to 67%, reduced poly(ADP-ribose)polymerase-1 expression and cleavage 2- to 4-fold, and elevated levels of p27 in the distal colon 3-fold. Studies in cancer cell cultures recapitulated actions of GT-094: antiproliferative activity and transient G sub(2)-M phase cell cycle block were measured in Caco-2 cells; apoptotic activity was examined but not observed; anti-inflammatory activity was seen in the inhibition of up-regulation of iNOS and endogenous NO production in lipopolysaccharide (LPS)-induced RAW 264.7 cells. In summary, antiproliferative, anti-inflammatory, and cytoprotective activity observed in vivo and in vitro support GT-094 as a lead compound for the design of NO chimeras for colorectal cancer chemoprevention. [Mol Cancer Ther 2007; 6(8):2230-9] JF - Molecular Cancer Therapeutics AU - Hagos, Ghenet K AU - Carroll, Robert E AU - Kouznetsova, Tatiana AU - Li, Qian AU - Toader, Violeta AU - Fernandez, Patricia A AU - Swanson, Steven M AU - Thatcher, Gregory RJ AD - Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago and Department of Medicine, University of Illinois at Chicago and Chicago Veterans Administration Medical Center (West Side Division), Chicago, Illinois Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2230 EP - 2239 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 8 SN - 1535-7163, 1535-7163 KW - Biotechnology and Bioengineering Abstracts KW - Cyclooxygenase-2 KW - Nitrate KW - Donors KW - Apoptosis KW - Cell cycle KW - Colorectal cancer KW - Animal models KW - Cell culture KW - Pain KW - Carcinogens KW - Colon cancer KW - Inflammation KW - Nitric-oxide synthase KW - Chimeras KW - Azoxymethane KW - chemopreventive agents KW - Lipopolysaccharides KW - Nitric oxide KW - Antiinflammatory agents KW - pharmacophores KW - Side effects KW - Nonsteroidal antiinflammatory drugs KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20143237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=Colon+cancer+chemoprevention+by+a+novel+NO+chimera+that+shows+anti-inflammatory+and+antiproliferative+activity+in+vitro+and+in+vivo&rft.au=Hagos%2C+Ghenet+K%3BCarroll%2C+Robert+E%3BKouznetsova%2C+Tatiana%3BLi%2C+Qian%3BToader%2C+Violeta%3BFernandez%2C+Patricia+A%3BSwanson%2C+Steven+M%3BThatcher%2C+Gregory+RJ&rft.aulast=Hagos&rft.aufirst=Ghenet&rft.date=2007-08-01&rft.volume=6&rft.issue=8&rft.spage=2230&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Nitrate; Donors; Apoptosis; Cell cycle; Animal models; Colorectal cancer; Pain; Cell culture; Colon cancer; Carcinogens; Inflammation; Nitric-oxide synthase; Chimeras; Azoxymethane; Lipopolysaccharides; chemopreventive agents; Nitric oxide; Antiinflammatory agents; Side effects; pharmacophores; Nonsteroidal antiinflammatory drugs ER - TY - JOUR T1 - Closing a Front Door to Homelessness among Veterans AN - 19755523; 7570153 AB - The U.S. Department of Veterans Affairs (VA) has been identified as a mainstream institution to help prevent homelessness among America's veterans. The large numbers of incarcerated veterans with serious mental illnesses and substance abuse disorders who are at risk for homelessness support the need for expanded VA outreach to this population. Since 2002, the VA has contacted almost 6,500 veterans in prison or jail. Its leadership role in affording comprehensive health, mental health, social resources, corrections outreach, and current policy and planning strategies positions the VA to provide system wide service to veterans leaving correctional institutions. As this VA outreach program proceeds, examining the links among program assumptions, veteran needs and outcomes, and existing evaluation processes can help to maintain focus on homelessness prevention strategies. JF - Journal of Primary Prevention AU - McGuire, James AD - VA West Los Angeles Healthcare Center, Building 206, Room 109, 11030 Wilshire Blvd., Los Angeles, CA, 90073, USA, James.McGuire@va.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 389 EP - 400 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 28 IS - 3-4 SN - 0278-095X, 0278-095X KW - Risk Abstracts KW - prisons KW - substance abuse KW - USA KW - prevention KW - outreach programs KW - Military KW - mental disorders KW - Homelessness KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19755523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Primary+Prevention&rft.atitle=Closing+a+Front+Door+to+Homelessness+among+Veterans&rft.au=McGuire%2C+James&rft.aulast=McGuire&rft.aufirst=James&rft.date=2007-08-01&rft.volume=28&rft.issue=3-4&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Journal+of+Primary+Prevention&rft.issn=0278095X&rft_id=info:doi/10.1007%2Fs10935-007-0091-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - substance abuse; prisons; outreach programs; prevention; Military; mental disorders; Homelessness; USA DO - http://dx.doi.org/10.1007/s10935-007-0091-y ER - TY - JOUR T1 - Onset of Symptoms and Time to Diagnosis of Clostridium difficile-Associated Disease Following Discharge From an Acute Care Hospital AN - 19724403; 7521248 AB - OBJECTIVE. To identify patients with a diagnosis of Clostridium difficile-associated disease (CDAD) in the ambulatory care setting and determine the relationship of symptom onset and diagnosis to prior hospitalization and exposure to antimicrobials. design. Single-center, retrospective study. METHODS. Medical records were reviewed for outpatients and hospitalized patients with a stool assay positive for C. difficile toxin A from January 1998 through March 2005. Patients with recurrent CDAD or residing in an extended-care facility were excluded. CDAD in patients who had been hospitalized in the 100 days prior to diagnosis was considered potentially hospital-associated. RESULTS. Of the 84 patients who met the inclusion criteria, 75 (89%) received a diagnosis 1-60 days after hospital discharge (median, 12 days), and 71 (85%) received a diagnosis within 30 days after discharge. Of the 69 patients whose records contained information regarding time of symptom onset, 62 (90%) developed diarrhea within 30 days of a previous hospital discharge, including 7 patients with symptom onset prior to discharge and 9 with onset on the day of discharge. The median time from symptom onset to diagnosis was 6 days. Of 84 patients, 77 (92%) had received antimicrobials during a prior hospitalization, but 55 (65%) received antimicrobials both as inpatients and as outpatients. CONCLUSION. If all cases of CDAD diagnosed within 100 days of hospital discharge were assumed to be hospital-associated, 71 (85%) of 84 patients with CDAD were identified within 30 days, and 75 (89%) of 84 were identified by day 60. Continued outpatient antimicrobial exposure confounds determination of whether late-onset cases are community- or hospital-associated. JF - Infection Control and Hospital Epidemiology AU - Chang, H T AU - Krezolek, D AU - Johnson, S AU - Parada, J P AU - Evans, C T AU - Gerding, D N AD - Research Service (151), Hines VA Hospital, Fifth Avenue and Roosevelt Road, Bldg 1, Rm C344, Hines, IL 60141, USA, dale.gerding2@va.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 926 EP - 931 VL - 28 IS - 8 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - Toxin A KW - Clostridium KW - Diarrhea KW - medical records KW - Feces KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19724403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Onset+of+Symptoms+and+Time+to+Diagnosis+of+Clostridium+difficile-Associated+Disease+Following+Discharge+From+an+Acute+Care+Hospital&rft.au=Chang%2C+H+T%3BKrezolek%2C+D%3BJohnson%2C+S%3BParada%2C+J+P%3BEvans%2C+C+T%3BGerding%2C+D+N&rft.aulast=Chang&rft.aufirst=H&rft.date=2007-08-01&rft.volume=28&rft.issue=8&rft.spage=926&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Toxin A; Diarrhea; medical records; Feces; Hospitals; Clostridium ER - TY - JOUR T1 - Bupropion and nicotine patch as smoking cessation aids in alcoholics AN - 19606604; 8602068 AB - This is a double-blind placebo-controlled study of sustained-release bupropion as a smoking cessation aid in alcoholics undergoing treatment for their alcoholism. Participants (N = 58) were enrolled within 1 week of entry into alcohol treatment from community and Veterans Affairs Substance Use Disorder programs. All participants received nicotine patch and were invited to attend a smoking cessation lecture and group. Cigarette smoking and alcohol outcomes were measured at 6 months. Bupropion when added to nicotine patch did not improve smoking outcomes. One third of participants on bupropion reported discontinuing the drug during weeks 1-4. Participants reported cigarette outcomes with nicotine patch that are similar to those seen in the general population. All study participants significantly reduced cigarette use. Comorbid affective disorder or antipersonality disorder did not affect outcomes. Alcohol outcomes were improved in those who discontinued cigarettes. JF - Alcohol AU - Grant, Kathleen M AU - Kelley, Stephanie Sinclair AU - Smith, Lynette M AU - Agrawal, Sangeeta AU - Meyer, James R AU - Romberger, Debra J AD - Substance Use Disorders Program, 116A4, Veterans Administration Nebraska Western Iowa Health Care System (Omaha site), 4101 Woolworth Avenue, Omaha, NE 68105, USA, Kathleen.grant2@med.va.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 381 EP - 391 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 41 IS - 5 SN - 0741-8329, 0741-8329 KW - Virology & AIDS Abstracts; Toxicology Abstracts KW - Smoking cessation KW - Alcoholism KW - Bupropion KW - Nicotine replacement KW - Nicotine dependence KW - bupropion KW - Affective disorders KW - Drug abuse KW - Controlled release KW - Alcoholics KW - Smoking KW - Nicotine KW - Cigarette smoking KW - Drug addiction KW - Drugs KW - Ethanol KW - V 22360:AIDS and HIV KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19606604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol&rft.atitle=Bupropion+and+nicotine+patch+as+smoking+cessation+aids+in+alcoholics&rft.au=Grant%2C+Kathleen+M%3BKelley%2C+Stephanie+Sinclair%3BSmith%2C+Lynette+M%3BAgrawal%2C+Sangeeta%3BMeyer%2C+James+R%3BRomberger%2C+Debra+J&rft.aulast=Grant&rft.aufirst=Kathleen&rft.date=2007-08-01&rft.volume=41&rft.issue=5&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/10.1016%2Fj.alcohol.2007.03.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Smoking; bupropion; Nicotine; Affective disorders; Alcoholism; Cigarette smoking; Drug abuse; Drug addiction; Drugs; Controlled release; Alcoholics; Ethanol DO - http://dx.doi.org/10.1016/j.alcohol.2007.03.011 ER - TY - JOUR T1 - Task-dependent costs in processing two simultaneous auditory stimuli. AN - 85401660; pmid-17929698 AB - A listener presented with two speech signals must at times sacrifice the processing of one signal in order to understand the other. This study was designed to distinguish costs related to interference from a second signal (selective attention) from costs related to performing two tasks simultaneously (divided attention). Listeners presented with two processed speech-in-noise stimuli, one to each ear, either (1) identified keywords in both or (2) identified keywords in one and detected the presence of speech in the other. Listeners either knew which ear to report in advance (single task) or were cued afterward (partial-report dual task). When the dual task required two identification judgments, performance suffered relative to the single-task condition (as measured by percent correct judgments). Two different tasks (identification for one stimulus and detection for the other) resulted in much smaller reductions in performance when the cue came afterward. We concluded that the degree to which listeners can simultaneously process dichotic speech stimuli seems to depend not only on the amount of interference between the two stimuli, but also on whether there is competition for limited processing resources. We suggest several specific hypotheses as to the structural mechanisms that could constitute these limited resources. JF - Perception & psychophysics AU - Gallun, Frederick J AU - Mason, Christine R AU - Kidd, Gerald AD - Boston University, Boston, Massachusetts, USA. frederick.gallun@va.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 757 EP - 771 VL - 69 IS - 5 SN - 0031-5117, 0031-5117 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Attention KW - *Auditory Perception KW - Female KW - Humans KW - Male KW - Signal Detection, Psychological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85401660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perception+%26+psychophysics&rft.atitle=Task-dependent+costs+in+processing+two+simultaneous+auditory+stimuli.&rft.au=Gallun%2C+Frederick+J%3BMason%2C+Christine+R%3BKidd%2C+Gerald&rft.aulast=Gallun&rft.aufirst=Frederick&rft.date=2007-07-01&rft.volume=69&rft.issue=5&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=Perception+%26+psychophysics&rft.issn=00315117&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Inhaled amyl nitrite effectively reverses acute catastrophic thromboxane-mediated pulmonary hypertension in pigs. AN - 70764272; 17644883 AB - Acute catastrophic pulmonary vasoconstriction frequently leads to cardiovascular collapse. Rapid and selective pulmonary vasodilation is desired in order to restore haemodynamic stability. This pilot study examined the effectiveness of inhaled amyl nitrite as a selective pulmonary vasodilator. Nine adult swine were anaesthetized. Acute pulmonary hypertension with haemodynamic collapse was induced with a bolus administration of a thromboxane analogue, U46619. Six animals then received a capsule of amyl nitrite. The administration of inhaled amyl nitrite decreased mean pulmonary artery pressure from 42 +/- 3 to 22 +/ 3 mmHg at five minutes (p < 0.05), with a concomitant increase in cardiac output and mean arterial pressure. Pulmonary vascular resistance decreased from 4889 +/- 1338 to 380 +/- 195 dyne. sec. cm(-5) (by 92% from the maximal pulmonary hypertension change), with significant improvement in systemic haemodynamics. During acute thromboxane-mediated pulmonary hypertension with cardiovascular collapse, prompt administration of inhaled amyl nitrite was effective in restoring pulmonary and systemic haemodynamics within five minutes. JF - Annals of cardiac anaesthesia AU - Muehlschlegel, Jochen D AU - Lobato, Emilio B AU - Kirby, David S AU - Arnaoutakis, G AU - Sidi, Anver AD - Department of Anesthesiology, University of Florida College of Medicine and Anesthesia Service, Malcom Randall Veterans Administration Medical Center, Gainesville, Florida 32610-0254, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 113 EP - 120 VL - 10 IS - 2 SN - 0971-9784, 0971-9784 KW - Vasoconstrictor Agents KW - 0 KW - Vasodilator Agents KW - 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid KW - 76898-47-0 KW - Amyl Nitrite KW - 8017-89-8 KW - Index Medicus KW - Swine KW - Acute Disease KW - Animals KW - Pulmonary Circulation -- drug effects KW - Disease Models, Animal KW - Pilot Projects KW - Administration, Inhalation KW - Hypertension, Pulmonary -- drug therapy KW - Amyl Nitrite -- administration & dosage KW - Hypertension, Pulmonary -- chemically induced KW - Vasodilator Agents -- administration & dosage KW - Vasodilator Agents -- therapeutic use KW - Vasoconstriction -- drug effects KW - Amyl Nitrite -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70764272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+cardiac+anaesthesia&rft.atitle=Inhaled+amyl+nitrite+effectively+reverses+acute+catastrophic+thromboxane-mediated+pulmonary+hypertension+in+pigs.&rft.au=Muehlschlegel%2C+Jochen+D%3BLobato%2C+Emilio+B%3BKirby%2C+David+S%3BArnaoutakis%2C+G%3BSidi%2C+Anver&rft.aulast=Muehlschlegel&rft.aufirst=Jochen&rft.date=2007-07-01&rft.volume=10&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Annals+of+cardiac+anaesthesia&rft.issn=09719784&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Secondary hypertension due to drugs and toxins. AN - 70741618; 17639749 AB - This review summarizes the current state of knowledge about drugs, other chemical substances, and toxins on blood pressure. Many classes of drugs, such as steroids, sympathomimetic amines, immunosuppressive agents, nonsteroidal anti-inflammatory agents, antidepressants, erythropoietin, substances of abuse and other agents can induce transient or sustained hypertension, exacerbate well-controlled hypertension, antagonize the effects of antihypertensive therapy, or precipitate hypertensive emergencies. Heightened awareness on the part of the physician is important to avoid unnecessary tests in search for other etiologies, and to reduce antihypertensive medication prescriptions by eliminating contributing agents whenever possible. These agents represent an important modifiable cause of secondary or resistant hypertension. JF - Southern medical journal AU - Gyamlani, Geeta AU - Geraci, Stephen A AD - Department of Internal Medicine, University of Mississippi School of Medicine, G.V. (Sonny) Montgomery VAMC, Jackson, Mississippi 39216, USA. Geeta.Gyamlani@va.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 692 EP - 9; quiz 700, 708 VL - 100 IS - 7 SN - 0038-4348, 0038-4348 KW - Toxins, Biological KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Medical History Taking KW - Hypertension -- chemically induced KW - Drug-Related Side Effects and Adverse Reactions KW - Toxins, Biological -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70741618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Secondary+hypertension+due+to+drugs+and+toxins.&rft.au=Gyamlani%2C+Geeta%3BGeraci%2C+Stephen+A&rft.aulast=Gyamlani&rft.aufirst=Geeta&rft.date=2007-07-01&rft.volume=100&rft.issue=7&rft.spage=692&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-09 N1 - Date created - 2007-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: South Med J. 2007 Jul;100(7):665-6 [17639743] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacological treatment of geriatric cachexia: evidence and safety in perspective. AN - 70702791; 17619035 AB - Anticachexic or antisarcopenic medications are prescribed worldwide for geriatric patients with poor appetite and associated weight loss. They represent a valuable treatment option for managing cachexia. However, the well-publicized adverse reports about these medications in acquired immunodeficiency syndrome (AIDS) and in the cancer population has led to some concern and much subsequent discussion over the safety of these medications being used in geriatric population. This review looks at the evidence in relation to the benefits and risks of these medications and discusses what we know about their use in the geriatric population. JF - Journal of the American Medical Directors Association AU - Yeh, Shing-Shing AU - Lovitt, Sherri AU - Schuster, Michael W AD - Northport VAMC, Geriatric division, Northport, NY 11768, USA. shingshing.yeh@med.va.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 363 EP - 377 VL - 8 IS - 6 KW - Anabolic Agents KW - 0 KW - Appetite Stimulants KW - Dronabinol KW - 7J8897W37S KW - Megestrol Acetate KW - TJ2M0FR8ES KW - Index Medicus KW - Dronabinol -- therapeutic use KW - Humans KW - Aged KW - Parenteral Nutrition KW - Dronabinol -- adverse effects KW - Megestrol Acetate -- therapeutic use KW - Cachexia -- drug therapy KW - Appetite Stimulants -- adverse effects KW - Anabolic Agents -- therapeutic use KW - Geriatrics KW - Cachexia -- etiology KW - Appetite Stimulants -- therapeutic use KW - Megestrol Acetate -- adverse effects KW - Cachexia -- physiopathology KW - Anabolic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70702791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Directors+Association&rft.atitle=Pharmacological+treatment+of+geriatric+cachexia%3A+evidence+and+safety+in+perspective.&rft.au=Yeh%2C+Shing-Shing%3BLovitt%2C+Sherri%3BSchuster%2C+Michael+W&rft.aulast=Yeh&rft.aufirst=Shing-Shing&rft.date=2007-07-01&rft.volume=8&rft.issue=6&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Directors+Association&rft.issn=1538-9375&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-25 N1 - Date created - 2007-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cardiovascular effects of antipsychotics. AN - 70691928; 17610390 AB - There is great concern over cardiovascular disease in the schizophrenic population owing to the high incidence of cardiovascular mortality. Increased cardiovascular mortality is related to lifestyle choices (e.g., smoking and sedentary lifestyle) and a high prevalence of comorbid medical conditions, including dyslipidemia, the metabolic syndrome and Type 2 diabetes. One factor that increases cardiovascular risk is the medications used to treat the core features of schizophrenia. Adverse cardiovascular effects of antipsychotic treatment have been recognized for many decades, especially tachycardia, orthostatic hypotension and rare instances of sudden death; but, since 2000, there has been a significant shift in the focus of risk perception. The older antipsychotic literature is replete with papers primarily concerned with the physiological consequences of muscarinic cholinergic antagonism, alpha(1)-adrenergic antagonism or receptors associated with cardiac conduction, but the current literature recognizes that, for most antipsychotic-exposed patients, the more significant cardiovascular burden of treatment is mediated by metabolic adverse effects such as weight gain, dyslipidemia and diabetes mellitus. The purpose of this review is to examine the cardiovascular risks of treatment with antipsychotic medications, elucidating relevant mechanisms and differences between various agents, especially for metabolic adverse effects seen with atypical antipsychotics. JF - Expert review of neurotherapeutics AU - Michelsen, James W AU - Meyer, Jonathan M AD - University of California, San Diego, Department of Medicine, CA, USA. james.michelsen2@va.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 829 EP - 839 VL - 7 IS - 7 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Heart Rate -- drug effects KW - Hyperlipidemias -- chemically induced KW - Humans KW - Body Weight -- drug effects KW - Hypotension, Orthostatic -- chemically induced KW - Myocarditis -- chemically induced KW - Cardiomyopathies -- chemically induced KW - Insulin Resistance KW - Tachycardia -- chemically induced KW - Diabetes Mellitus, Type 2 -- chemically induced KW - Death, Sudden, Cardiac -- etiology KW - Cardiovascular Diseases -- chemically induced KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70691928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+review+of+neurotherapeutics&rft.atitle=Cardiovascular+effects+of+antipsychotics.&rft.au=Michelsen%2C+James+W%3BMeyer%2C+Jonathan+M&rft.aulast=Michelsen&rft.aufirst=James&rft.date=2007-07-01&rft.volume=7&rft.issue=7&rft.spage=829&rft.isbn=&rft.btitle=&rft.title=Expert+review+of+neurotherapeutics&rft.issn=1744-8360&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-17 N1 - Date created - 2007-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clostridium difficile: recent epidemiologic findings and advances in therapy. AN - 70657702; 17594209 AB - Clostridium difficile-associated disease (CDAD) has become an important public health problem. The causative organism is acquired by the oral route from an environmental source or by contact with an infected person or a health care worker who serves as a vector. Disruption of the bowel microflora, generally by antibiotics, creates an environment that allows C. difficile to proliferate. Organisms produce toxins A and B, which cause intense inflammation of the colonic mucosa. The syndrome that results includes severe diarrhea, fever, abdominal pain, and leukocytosis. A new strain of C. difficile has become prevalent in the United States, Canada, and the United Kingdom. Identified by pulsed-field gel electrophoresis (PFGE), this strain is called North America PFGE type 1, abbreviated as NAP-1. Clostridium difficile NAP-1 characteristically generates large amounts of toxins A and B, as well as an additional binary toxin and is associated with enhanced morbidity and a poor response to antibiotic therapy. Mild cases of CDAD may respond to cessation of antibiotic therapy, perhaps related to antibody production by the infected person, but most infected persons require antimicrobial therapy. Vancomycin has been approved by the United States Food and Drug Administration for treatment of CDAD, but reluctance to use this antibiotic in the hospital setting has led to reliance on metronidazole as first-line therapy. Recent studies show a high rate of failure, due either to infection by NAP-1 or to the presence, in hospitals, of older and sicker adults who have been treated with many broad-spectrum antibiotics. Nitazoxanide, bacitracin, teicoplanin, and fusidic acid are additional agents that have published efficacy for this indication in humans. Rifaximin and PAR-101 are under investigation. Other therapies, including polymers that bind C. difficile toxin and monoclonal antibodies to toxins, and preventive measures such as toxoid vaccines are also under study. JF - Pharmacotherapy AU - McMaster-Baxter, Nicole L AU - Musher, Daniel M AD - Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA. nicole.mcmaster@va.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1029 EP - 1039 VL - 27 IS - 7 SN - 0277-0008, 0277-0008 KW - Anti-Bacterial Agents KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Clostridium difficile KW - Anti-Bacterial Agents -- therapeutic use KW - Clostridium Infections -- drug therapy KW - Clostridium Infections -- epidemiology KW - Anti-Bacterial Agents -- adverse effects KW - Clostridium Infections -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70657702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Clostridium+difficile%3A+recent+epidemiologic+findings+and+advances+in+therapy.&rft.au=McMaster-Baxter%2C+Nicole+L%3BMusher%2C+Daniel+M&rft.aulast=McMaster-Baxter&rft.aufirst=Nicole&rft.date=2007-07-01&rft.volume=27&rft.issue=7&rft.spage=1029&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-30 N1 - Date created - 2007-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The utility of adding retrospective medication profiling to computerized provider order entry in an ambulatory care population. AN - 70656748; 17460134 AB - We assessed whether medication safety improved when a medication profiling program was added to a computerized provider order entry system. Between June 2001 and January 2002 we profiled outpatients with potential prescribing errors using computerized retrospective drug utilization software. We focused primarily on drug interactions. Patients were randomly assigned either to Provider Feedback or to Usual Care. Subsequent adverse drug event (ADE) incidence and other outcomes, including ADE preventability and severity, occurring up to 1 year following the last profiling date were evaluated retrospectively by a pharmacist blinded to patient assignment. Data were abstracted using a study-designed instrument. An ADE was defined by an Adverse Drug Reaction Probability scale score of 1 or more. Statistical analyses included negative binomial regression for comparing ADE incidence. Of 913 patients in the analytic sample, 371 patients (41%) had one or more ADEs. Incidence, by individual, was not significantly different between Usual Care and Provider Feedback groups (37% vs. 45%; p = 0.06; Coefficient, 0.19; 95% CI: -0.008, 0.390). ADE severity was also similar. For example, 51% of ADEs in the Usual Care and 58% in the Provider Feedback groups involved symptoms that were not serious (95% CI for the difference, -15%, 2%). Finally, ADE preventability did not differ. For example, 16% in the Usual Care group and 17% in the Provider Feedback group had an associated warning (95% CI for the difference, -7 to 5%; p = 0.79). Medications safety did not improve with the addition of a medication profiling program to an electronic prescribing system. JF - Journal of the American Medical Informatics Association : JAMIA AU - Glassman, Peter A AU - Belperio, Pamela AU - Lanto, Andrew AU - Simon, Barbara AU - Valuck, Robert AU - Sayers, Jeffrey AU - Lee, Martin AD - Division of General Internal Medicine (111G), VA Greater Los Angeles Healthcare System, West Los Angeles Campus, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA. Peter.Glassman@va.gov PY - 2007 SP - 424 EP - 431 VL - 14 IS - 4 SN - 1067-5027, 1067-5027 KW - Index Medicus KW - Ambulatory Care Information Systems KW - Drug Interactions KW - Medication Errors -- prevention & control KW - Humans KW - Reminder Systems KW - Decision Support Systems, Clinical KW - Medication Systems KW - Drug-Related Side Effects and Adverse Reactions -- epidemiology KW - Drug-Related Side Effects and Adverse Reactions -- prevention & control KW - Drug Therapy, Computer-Assisted KW - Medical Order Entry Systems -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70656748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association+%3A+JAMIA&rft.atitle=The+utility+of+adding+retrospective+medication+profiling+to+computerized+provider+order+entry+in+an+ambulatory+care+population.&rft.au=Glassman%2C+Peter+A%3BBelperio%2C+Pamela%3BLanto%2C+Andrew%3BSimon%2C+Barbara%3BValuck%2C+Robert%3BSayers%2C+Jeffrey%3BLee%2C+Martin&rft.aulast=Glassman&rft.aufirst=Peter&rft.date=2007-07-01&rft.volume=14&rft.issue=4&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association+%3A+JAMIA&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-19 N1 - Date created - 2007-06-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 1998 Oct 21;280(15):1311-6 [9794308] JAMA. 1998 Oct 14;280(14):1249-52 [9786375] Health Care Financ Rev. 1999 Spring;20(3):107-18 [10558015] Am J Manag Care. 2005 Feb;11(2):93-102 [15726857] JAMA. 2005 Mar 9;293(10):1197-203 [15755942] JAMA. 2005 Mar 9;293(10):1261-3 [15755949] Am J Med Qual. 2005 Jan-Feb;20(1):7-14 [15782750] Arch Intern Med. 2005 May 23;165(10):1111-6 [15911723] Med Care. 2005 Dec;43(12):1171-6 [16299427] J Am Med Inform Assoc. 2006 Jan-Feb;13(1):5-11 [16221941] Arch Intern Med. 2006 Feb 13;166(3):338-44 [16476875] Med Care. 2006 Mar;44(3):250-6 [16501396] Lancet. 2000 Oct 7;356(9237):1255-9 [11072960] Lancet. 2000 Oct 28;356(9240):1505-11 [11081549] Proc AMIA Symp. 2002;:602-6 [12463894] JAMA. 2003 Mar 5;289(9):1107-16 [12622580] N Engl J Med. 2003 Apr 17;348(16):1556-64 [12700376] Arch Intern Med. 2003 Jun 23;163(12):1409-16 [12824090] JAMA. 2003 Sep 17;290(11):1494-9 [13129990] J Manag Care Pharm. 2003 Nov-Dec;9(6):513-22 [14664659] Ann Intern Med. 2004 May 18;140(10):795-801 [15148066] Clin Pharmacol Ther. 1981 Aug;30(2):239-45 [7249508] Am J Hosp Pharm. 1992 Jan;49(1):90-6 [1570873] Med Care. 1993 Dec;31(12):1069-82 [8246637] Med Care Rev. 1994 Spring;51(1):3-37 [10133004] N Engl J Med. 1995 Jun 15;332(24):1641-5 [7753146] JAMA. 1995 Jul 5;274(1):29-34 [7791255] JAMA. 1995 Jul 5;274(1):35-43 [7791256] Arch Intern Med. 1995 Oct 9;155(18):1949-56 [7575048] JAMA. 1997 Jan 22-29;277(4):301-6 [9002492] Arch Intern Med. 1997 Oct 27;157(19):2205-10 [9342997] JAMA. 1998 Apr 15;279(15):1200-5 [9555760] JAMA. 1998 Oct 21;280(15):1317-20 [9794309] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic smoking is associated with differential neurocognitive recovery in abstinent alcoholic patients: a preliminary investigation. AN - 70610384; 17451399 AB - Approximately 50 to 90% of individuals in North America seeking treatment for alcoholism are chronic smokers. A growing body of evidence suggests that chronic cigarette smokers show a pattern of neurocognitive dysfunction similar to that observed in alcoholic patients. However, previous studies investigating neurocognitive recovery in abstinent alcoholic patients did not specifically consider the potential effects of chronic cigarette smoking. This study comprehensively compared longitudinal neurocognitive changes over 6 to 9 months of abstinence among 13 nonsmoking recovering alcoholic patients (ALC) and 12 actively smoking ALC. The neurocognitive performance of the alcoholic groups was compared with nonsmoking light-drinking controls (nonsmoking LD). Nonsmoking ALC exhibited a significantly greater magnitude of longitudinal improvement than smoking ALC on measures of cognitive efficiency, executive skills, visuospatial skills, and working memory. Both nonsmoking ALC and smoking ALC demonstrated equivalent improvement on auditory-verbal learning, auditory-verbal memory, and processing speed. Nonsmoking LD showed no significant changes in neurocognition over time. In cross-sectional comparisons at 6 to 9 months of abstinence, nonsmoking ALC were superior to smoking ALC on measures of auditory-verbal learning, auditory-verbal memory, cognitive efficiency, executive skills, processing speed, and working memory. The longitudinal and cross-sectional neurocognitive differences observed between nonsmoking and smoking ALC remained significant after covarying for group differences in education, estimated premorbid intelligence alcohol consumption, and other potentially confounding variables. In smoking ALC, greater smoking severity was inversely related to longitudinal improvement on multiple neurocognitive measures. These preliminary results suggest that chronic smoking may modulate neurocognitive recovery in abstinent alcoholic patients. More generally, chronic smoking may impact neurocognition in other conditions where is it a prevalent behavior. JF - Alcoholism, clinical and experimental research AU - Durazzo, Timothy C AU - Rothlind, Johannes C AU - Gazdzinski, Stefan AU - Banys, Peter AU - Meyerhoff, Dieter J AD - San Francisco Veterans Administration Medical Center, San Francisco, CA 94121, USA. timothy.durazzo@ucsf.edu Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1114 EP - 1127 VL - 31 IS - 7 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Severity of Illness Index KW - Cross-Sectional Studies KW - Postural Balance -- physiology KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Chronic Disease KW - Longitudinal Studies KW - Alcohol Drinking -- epidemiology KW - Male KW - Female KW - Comorbidity KW - Prevalence KW - Neuropsychological Tests -- statistics & numerical data KW - Alcoholism -- rehabilitation KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Smoking -- adverse effects KW - Smoking -- psychology KW - Temperance -- statistics & numerical data KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70610384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Chronic+smoking+is+associated+with+differential+neurocognitive+recovery+in+abstinent+alcoholic+patients%3A+a+preliminary+investigation.&rft.au=Durazzo%2C+Timothy+C%3BRothlind%2C+Johannes+C%3BGazdzinski%2C+Stefan%3BBanys%2C+Peter%3BMeyerhoff%2C+Dieter+J&rft.aulast=Durazzo&rft.aufirst=Timothy&rft.date=2007-07-01&rft.volume=31&rft.issue=7&rft.spage=1114&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-24 N1 - Date created - 2007-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Substance use-disorder treatment and a decline in attempted suicide during and after treatment. AN - 70606305; 17568953 AB - Suicide attempts are common in patients being treated for substance-use disorders (SUDs). However, little is known about the frequency of suicidal behavior during and after SUD treatment or about aspects of treatment that predict subsequent suicidal behavior. The present study examines whether treatment setting, length of treatment, and availability/use of psychiatric services are associated with a reduced likelihood of a suicide attempt during and 1 year after treatment. A national sample of 3,733 patients was assessed at the start of an episode of SUD treatment and again at discharge and/or 1 year after treatment. Mixed-model logistic regression analyses examined treatment-related predictors of in-treatment and posttreatment suicide attempts. The rate of suicide attempts was significantly lower in the year following treatment (4%) than in the year before treatment (9%). Additionally, a total of 2% of patients reported a suicide attempt during treatment. Suicide attempts made during treatment were less likely in patients treated in residential as compared with outpatient settings. A longer course of treatment was associated with a lower likelihood of a posttreatment suicide attempt. A sizable minority of patients report a suicide attempt either during or within 1 year after completion of SUD treatment. Even after controlling for baseline suicidality, aspects of the SUD treatment episode are associated with a lower risk of a future suicide attempt. Treatment providers should consider placing patients in residential settings to reduce suicide attempts made during treatment and providing a longer course of treatment to reduce the likelihood of suicide following treatment. JF - Journal of studies on alcohol and drugs AU - Ilgen, Mark A AU - Jain, Anuja AU - Lucas, Emma AU - Moos, Rudolf H AD - Center for Health Care Evaluation, Department of Veterans Affairs Palo Alto Health Care System, 795 Willow Road (MPD 152), Menlo Park, California 94025, USA. Mark.Ilgen@va.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 503 EP - 509 VL - 68 IS - 4 SN - 1937-1888, 1937-1888 KW - Crack Cocaine KW - 0 KW - Index Medicus KW - United States KW - Substance Abuse Treatment Centers -- statistics & numerical data KW - Length of Stay -- statistics & numerical data KW - Humans KW - Adult KW - Follow-Up Studies KW - Statistics as Topic KW - Longitudinal Studies KW - Likelihood Functions KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Alcoholism -- epidemiology KW - Suicide, Attempted -- statistics & numerical data KW - Cocaine-Related Disorders -- epidemiology KW - Substance-Related Disorders -- rehabilitation KW - Cocaine-Related Disorders -- rehabilitation KW - Suicide, Attempted -- prevention & control KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70606305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol+and+drugs&rft.atitle=Substance+use-disorder+treatment+and+a+decline+in+attempted+suicide+during+and+after+treatment.&rft.au=Ilgen%2C+Mark+A%3BJain%2C+Anuja%3BLucas%2C+Emma%3BMoos%2C+Rudolf+H&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2007-07-01&rft.volume=68&rft.issue=4&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol+and+drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-06 N1 - Date created - 2007-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Consistent adherence to guidelines improves opioid dependent patients' first year outcomes. AN - 68190743; 17610159 AB - Clinical practice guidelines for opioid substitution treatment (OST) for opioid dependence recommend that patients receive at least 60 mg daily methadone and have access to a broad array of psychosocial services. However, there is still wide variation in clinical practice in OST clinics. In real-world settings, patients could receive lower methadone doses and less psychosocial care because they require less intensive care for recovery; alternatively, barriers to delivery of guideline concordant care could limit treatment received and impair recovery. The Multisite Opioid Substitution Treatment (MOST) study examines the impact of more consistent adherence to guideline recommendations in eight Veterans Affairs OST clinics. While patients at all clinics demonstrated improvements in substance use over the first year in treatment, patients at clinics that more consistently adhered to guidelines had greater reductions in heroin and cocaine use and greater improvement in mental health. These results suggest that efforts to increase guideline adherence in OST will improve patient outcomes. JF - The journal of behavioral health services & research AU - Trafton, Jodie A AU - Humphreys, Keith AU - Harris, Alex H S AU - Oliva, Elizabeth AD - Center for Health Care Evaluation, Veterans Affairs and Stanford University Medical Centers, 795 Willow Road (152-MPD), Menlo Park, CA 94025, USA. Jodie.Trafton@va.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 260 EP - 271 VL - 34 IS - 3 SN - 1094-3412, 1094-3412 KW - Index Medicus KW - United States KW - Clinical Protocols -- standards KW - Substance Abuse Treatment Centers KW - United States Department of Veterans Affairs KW - Humans KW - Adult KW - Interviews as Topic KW - Middle Aged KW - Guidelines as Topic KW - Male KW - Female KW - Guideline Adherence KW - Outcome Assessment (Health Care) KW - Opioid-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68190743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+behavioral+health+services+%26+research&rft.atitle=Consistent+adherence+to+guidelines+improves+opioid+dependent+patients%27+first+year+outcomes.&rft.au=Trafton%2C+Jodie+A%3BHumphreys%2C+Keith%3BHarris%2C+Alex+H+S%3BOliva%2C+Elizabeth&rft.aulast=Trafton&rft.aufirst=Jodie&rft.date=2007-07-01&rft.volume=34&rft.issue=3&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=The+journal+of+behavioral+health+services+%26+research&rft.issn=10943412&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-20 N1 - Date created - 2007-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Impact of Chronic Hepatitis C on Health-Related Quality of Life in Homeless and Marginally Housed Individuals with HIV AN - 61419859; 200802138 AB - Although infection with Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) frequently co-exist, there has been little research to determine the effects of HIV/HCV co-infection on health-related quality of life (HRQOL). We performed a cross-sectional analysis of baseline data from 216 participants enrolled in a community based study of HIV-infected homeless and marginally housed individuals, using multivariable linear regression analysis to determine if co-infection with HCV was independently associated with lower short-form 36 (SF-36) questionnaire scores. We found that individuals with HCV had significantly lower mean SF-36 scores in the domains of physical functioning, bodily pain, social functioning and role limitation due to emotional health, and that HIV/HCV co-infection was independently associated with a lower physical component score but not a lower mental component score after controlling for numerous covariates. These results suggest that co-infection with HCV may have an adverse effect on HRQOL among homeless and marginally housed individuals with HIV. Adapted from the source document. JF - AIDS and Behavior AU - Tsui, Judith I AU - Bangsberg, David R AU - Ragland, Kathleen AU - Hall, Christopher S AU - Riley, Elise D AD - San Francisco Veterans Administration Medical Center, University of California San Francisco, 4150 Clement St., San Francisco, CA 94121, USA judith.tsui@va.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 603 EP - 610 PB - Springer, Dordrecht, The Netherlands VL - 11 IS - 4 SN - 1090-7165, 1090-7165 KW - Acquired Immune Deficiency Syndrome KW - Quality of Life KW - Health KW - Diseases KW - Homelessness KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61419859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=The+Impact+of+Chronic+Hepatitis+C+on+Health-Related+Quality+of+Life+in+Homeless+and+Marginally+Housed+Individuals+with+HIV&rft.au=Tsui%2C+Judith+I%3BBangsberg%2C+David+R%3BRagland%2C+Kathleen%3BHall%2C+Christopher+S%3BRiley%2C+Elise+D&rft.aulast=Tsui&rft.aufirst=Judith&rft.date=2007-07-01&rft.volume=11&rft.issue=4&rft.spage=603&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-006-9157-8 LA - English DB - Social Services Abstracts N1 - Date revised - 2008-04-02 N1 - Number of references - 36 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Diseases; Quality of Life; Homelessness; Acquired Immune Deficiency Syndrome; Health DO - http://dx.doi.org/10.1007/s10461-006-9157-8 ER - TY - JOUR T1 - Factors identifying high-frequency and low-frequency health service utilization among substance-using adults AN - 57057692; 200719453 AB - Understanding why substance-using patients seek care at emergency departments (EDs) and who utilizes such service at high rates is important in tailoring and targeting interventions. We conducted a retrospective/prospective cohort study of 326 medically ill substance-using adults to identify factors associated with 12-month high-frequency utilization of ambulatory care, ED, and inpatient medical care. The majority were actively using heroin (74.6%), cocaine (62.4%), and alcohol (54.4%); 94.8% had a chronic medical condition; and 53.8% reported a chronic mental health condition. High-frequency use of ED (>= 3 visits) was independently associated with being female (adjusted odds ratio [AOR] = 1.88; 95% confidence interval [95% CI] = 1.12, 3.17), being African American (AOR = 2.36; 95% CI = 1.30, 4.29), being homeless (AOR = 2.07; 95% CI = 1.08, 3.96), a history of > 1 substance abuse treatment episode (AOR = 4.10; 95% CI = 3.28, 10.87), and >= 1 ambulatory care visit (AOR = 8.94; 95% CI = 3.28, 24.41). However, the combination of having certain chronic conditions (seizure disorder, hepatitis B, and hepatitis C) and accessing ambulatory care was protective against high-frequency use of ED. In contrast, high-frequency use of ambulatory care (>= 3 visits) was independently associated with having insurance (Medicare/Medicaid: AOR = 2.39; 95% CI = 1.31, 4.69), having HIV/AIDS (AOR = 3.15; 95% CI = 1.70, 5.85), and receiving substance abuse treatment during the study period (AOR = 3.58; 95% CI = 1.61, 7.98) Efforts to redirect medical care to more subacute settings will likely require both capacity building and addressing a client's underlying needs, including homelessness, access to substance abuse treatment, and chronic disease management. [Copyright 2006 Elsevier Inc.] JF - Journal of Substance Abuse Treatment AU - O'Toole, Thomas P AU - Pollini, Robin AU - Gray, Paulette AU - Jones, Theodore AU - Bigelow, George AU - Ford, Daniel E AD - Johns Hopkins U School Medicine, Baltimore, MD thomas.o'toole@va.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 51 EP - 59 PB - Elsevier, New York NY VL - 33 IS - 1 SN - 0740-5472, 0740-5472 KW - Substance abuse KW - Health services utilization KW - Emergency department care KW - Ambulatory care KW - Integrated treatment KW - Users KW - Ambulatory health care KW - Integrated services KW - Accident and emergency departments KW - Health services KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57057692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Factors+identifying+high-frequency+and+low-frequency+health+service+utilization+among+substance-using+adults&rft.au=O%27Toole%2C+Thomas+P%3BPollini%2C+Robin%3BGray%2C+Paulette%3BJones%2C+Theodore%3BBigelow%2C+George%3BFord%2C+Daniel+E&rft.aulast=O%27Toole&rft.aufirst=Thomas&rft.date=2007-07-01&rft.volume=33&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/10.1016%2Fj.jsat.2006.12.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Substance abuse; Accident and emergency departments; Health services; Users; Ambulatory health care; Integrated services DO - http://dx.doi.org/10.1016/j.jsat.2006.12.002 ER - TY - JOUR T1 - Screening for Hemoglobinopathies During Routine Hemoglobin A1c Testing Using the Tosoh G7 Glycohemoglobin Analyzer AN - 21049349; 11322246 AB - Approximately 5.1% of the US population has diabetes mellitus, and hemoglobin (Hb) A1c levels are routinely measured to monitor long-term glycemic control in these patients. Many laboratories use ion exchange chromatography for such measurements, and the presence of hemoglobin variants and hemogbbinopathies often results in abnormal peaks on the chromatogram. The goal of this study was to evaluate the potential that detection of these abnormal peaks provides as a screening tool for Hb variants and hemoglobinopathies. We examined 366 specimens with abnormal peaks observed during routine Hb A1c measurements using the G7 Glycohemoglobin Analyzer (Tosoh Bioscience, Inc.). Hb variants and hemoglobinopathies were characterized by alkaline and acid electrophoresis, solubility testing for Hb S, and clinical parameters. In 252 cases, sickle cell trait was identified with a mean retention time (RT) of 1.44 (SD plus or minus 0.02) min. In 82 cases, Hb C trait was identified with a mean RT of 1.66 plus or minus 0.03 min. RTs for other Hb abnormalities, including sickle cell disease, homozygous Hb C disease, C Harlem trait. alpha -chain Hb variants, Hb D trait, Pb G trait, Hb J trait. Hb Raleigh, and Hb Lepore were also determined. Our results demonstrate that routine Hb A1c testing provides a potential screening tool for the detection of common hemoglobin variants and hemoglobinopathies.The previously unreported RTs for the G7 Glycohemoglobin Analyzer are provided which can facilitate further testing in previously undiagnosed patients and confirm the cause of abnormal peaks in patients with known hemoglobin abnormalities. JF - Annals of Clinical and Laboratory Science AU - Thomas, L B AU - Agosti, S J AU - Man, MA AU - Mastorldes, S M AD - Department of Pathology and Laboratory Medicine, James A. Haley VA Medical Center, 13000 Bruce B. Downs Blvd.. Tampa, FL 33612, USA, stephen.mastorides@med.va.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 251 EP - 255 VL - 37 IS - 3 SN - 0091-7370, 0091-7370 KW - Biotechnology and Bioengineering Abstracts KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21049349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Clinical+and+Laboratory+Science&rft.atitle=Screening+for+Hemoglobinopathies+During+Routine+Hemoglobin+A1c+Testing+Using+the+Tosoh+G7+Glycohemoglobin+Analyzer&rft.au=Thomas%2C+L+B%3BAgosti%2C+S+J%3BMan%2C+MA%3BMastorldes%2C+S+M&rft.aulast=Thomas&rft.aufirst=L&rft.date=2007-07-01&rft.volume=37&rft.issue=3&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Annals+of+Clinical+and+Laboratory+Science&rft.issn=00917370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Characterization of Tn5386, a Tn916-related mobile element AN - 20844810; 8241345 AB - In recent work, we described excision of a large genomic region from Enterococcus faecium D344R resulting from the interaction of Tn916 and a related transposon designated Tn5386. In the present study, we present and analyze the complete sequence of Tn5386. Tn5386 is 29,451 bp in length. Fifteen of its 30 open reading frames are analogous to ORFs found in Tn916. Significant differences include a series of ORFs with homology to lantibiotic immunity genes in the same location where tetM is found in Tn916, insertion of a Group II intron and an ORF with similarities to previously described surface exposed collagen adhesion proteins. Our results indicate that Tn5386 falls within the Tn916 family of transposons, and in place of tetM encodes a novel region that may confer resistance to lantibiotics. JF - Plasmid AU - Rice, L B AU - Carias, L L AU - Marshall, SH AU - Hutton-Thomas, R AU - Rudin, S AD - Case Western Reserve University, Cleveland, OH 44106, USA, louis.rice@med.va.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 61 EP - 67 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 58 IS - 1 SN - 0147-619X, 0147-619X KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Immunology Abstracts KW - Transposons KW - Homology KW - Lantibiotics KW - Introns KW - genomics KW - Immunity KW - Plasmids KW - Open reading frames KW - Enterococcus faecium KW - Collagen KW - J 02310:Genetics & Taxonomy KW - F 06910:Microorganisms & Parasites KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20844810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plasmid&rft.atitle=Characterization+of+Tn5386%2C+a+Tn916-related+mobile+element&rft.au=Rice%2C+L+B%3BCarias%2C+L+L%3BMarshall%2C+SH%3BHutton-Thomas%2C+R%3BRudin%2C+S&rft.aulast=Rice&rft.aufirst=L&rft.date=2007-07-01&rft.volume=58&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Plasmid&rft.issn=0147619X&rft_id=info:doi/10.1016%2Fj.plasmid.2007.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Transposons; Homology; Lantibiotics; Introns; Immunity; genomics; Plasmids; Open reading frames; Collagen; Enterococcus faecium DO - http://dx.doi.org/10.1016/j.plasmid.2007.01.002 ER - TY - JOUR T1 - Pseudomonas aeruginosa Delays Kupffer Cell Death via Stabilization of the X-Chromosome-Linked Inhibitor of Apoptosis Protein AN - 20612132; 7463413 AB - Kupffer cells are important for bacterial clearance and cytokine production during infection. We have previously shown that severe infection with Pseudomonas aeruginosa ultimately results in loss of Kupffer cells and hepatic bacterial clearance. This was associated with prolonged hepatic inflammation. However, there is a period of time during which there is both preserved hepatic bacterial clearance and increased circulating TNF- alpha . We hypothesized that early during infection, Kupffer cells are protected against TNF- alpha -induced cell death via activation of survival pathways. KC13-2 cells (a clonal Kupffer cell line) were treated with P. aeruginosa (strain PA103), TNF- alpha , or both. At early time points, TNF- alpha induced caspase-mediated cell death, but PA103 did not. When we combined the two exposures, PA103 protected KC13-2 cells from TNF- alpha -induced cell death. PA103, in the setting of TNF exposure, stabilized the X-chromosome-linked inhibitor of apoptosis protein (XIAP). Stabilization of XIAP can occur via PI3K and Akt. We found that PA103 activated Akt and that pretreatment with the PI3K inhibitor, LY294002, prevented PA103-induced protection against TNF- alpha -induced cell death. The effects of LY294002 included decreased levels of XIAP and increased amounts of cleaved caspase-3. Overexpression of Akt mimicked the effects of PA103 by protecting cells from TNF- alpha -induced cell death and XIAP cleavage. Transfection with a stable, nondegradable XIAP mutant also protected cells against TNF- alpha -induced cell death. These studies demonstrate that P. aeruginosa delays TNF- alpha -induced Kupffer cell death via stabilization of XIAP. JF - Journal of Immunology AU - Ashare, Alix AU - Monick, Martha M AU - Nymon, Amanda B AU - Morrison, John M AU - Noble, Matthew AU - Powers, Linda S AU - Yarovinsky, Timur O AU - Yahr, Timothy L AU - Hunninghake, Gary W AD - Division of Pulmonary, Critical Care, and Occupational Medicine, and Department of Microbiology, University of Iowa Roy J. and Lucille A. Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242 Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 505 EP - 513 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 1 SN - 0022-1767, 0022-1767 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Cell survival KW - Apoptosis KW - Infection KW - Cell activation KW - Inflammation KW - Kupffer cells KW - 1-Phosphatidylinositol 3-kinase KW - Transfection KW - XIAP protein KW - AKT protein KW - Liver KW - Caspase-3 KW - Cytokines KW - Tumor necrosis factor- alpha KW - Pseudomonas aeruginosa KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20612132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Pseudomonas+aeruginosa+Delays+Kupffer+Cell+Death+via+Stabilization+of+the+X-Chromosome-Linked+Inhibitor+of+Apoptosis+Protein&rft.au=Ashare%2C+Alix%3BMonick%2C+Martha+M%3BNymon%2C+Amanda+B%3BMorrison%2C+John+M%3BNoble%2C+Matthew%3BPowers%2C+Linda+S%3BYarovinsky%2C+Timur+O%3BYahr%2C+Timothy+L%3BHunninghake%2C+Gary+W&rft.aulast=Ashare&rft.aufirst=Alix&rft.date=2007-07-01&rft.volume=179&rft.issue=1&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; Apoptosis; Infection; Inflammation; Cell activation; Kupffer cells; 1-Phosphatidylinositol 3-kinase; Transfection; XIAP protein; Caspase-3; Liver; AKT protein; Cytokines; Tumor necrosis factor- alpha; Pseudomonas aeruginosa ER - TY - JOUR T1 - Risk-Adjusted Mortality Rates of Elderly Veterans with Hip Fractures AN - 20569197; 9270994 AB - Purpose The goal of this research was to estimate 12-month survival rates for a large sample of elderly veterans after hip fracture with a risk-adjusted model and to compare the results of men to those of women. Methods The study design was a retrospective, secondary data analysis of national Veterans Health Administration (VHA) Medicare beneficiaries. The study population was 43,165 veterans with hip fracture first admitted to a Medicare-eligible facility during our specified enrollment period of 1999-2002. Measurement was a Cox proportional hazard model or survival analysis of hip fracture patients with an outcome of death over a 1 year period after discharge controlled by age, gender, and selected Elixhauser comorbidities. Results The unadjusted, 1 year mortality rates (30 days = 9.7%, 90 days = 17.5%, 180 days = 24%, 365 days = 32.2%) were slightly higher than the adjusted rates (30 days = 8.9%, 90 days = 15.6%, 180 days = 21.8%, 1 year = 29.9%). The mortality odds for women 12 months after hip fracture were 18%, compared with 32% for men. The comorbidity adjustment suggested that the presence of metastatic cancer increased the risk of death by almost 4 times compared with those patients without this diagnosis. Other particularly high-risk conditions included congestive heart failure, renal failure, liver disease, lymphoma, and weight loss, each of which increased the 1 year mortality risk by approximately two-fold. Conclusions One in 3 elderly male veterans who sustain a hip fracture dies within 1 year. Our work represents the first large study of hip fractures with a predominantly male sample and confirms that men have a higher mortality risk than women, as reported by previous researchers who used smaller samples that were mostly female. Fracture patients with metastatic cancer, renal failure, lymphoma, weight loss, and liver disease have higher mortality risks. The adverse outcomes associated with hip fracture argue for clinical intervention strategies, such as gait and balance testing, and osteoporosis diagnosis that may prevent fractures in both genders. Key Words: Hip Fractures; Risk Adjusted; Survival Analysis; Mortality; Veterans JF - Annals of Epidemiology AU - Bass, Elizabeth AU - French, Dustin D AU - Bradham, Douglas D AU - Rubenstein, Laurence Z AD - From VISN-8 Patient Safety Center of Inquiry, James A. Haley Veterans Affairs Medical Center, Tampa, FL (E.B., D.D.F.); Cooperative Studies Program Coordinating Center at Perry Point, MD, and University of Maryland School of Medicine, Department of Epidemiology and Preventive Medicine (D.D.B.); and University of California Los Angeles David Geffen School of Medicine, and Veterans Affairs Greater Los Angeles Healthcare System Geriatric Research, Education and Clinical Center, Sepulveda and West Los Angeles Divisions (L.Z.R.), Elizabeth.Bass@va.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 514 EP - 519 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 17 IS - 7 SN - 1047-2797, 1047-2797 KW - Risk Abstracts KW - Mortality KW - Age KW - Cancer KW - Morbidity KW - hip fracture KW - osteoporosis KW - intervention KW - Gender KW - Liver KW - survival KW - elderly KW - lymphoma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20569197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Risk-Adjusted+Mortality+Rates+of+Elderly+Veterans+with+Hip+Fractures&rft.au=Bass%2C+Elizabeth%3BFrench%2C+Dustin+D%3BBradham%2C+Douglas+D%3BRubenstein%2C+Laurence+Z&rft.aulast=Bass&rft.aufirst=Elizabeth&rft.date=2007-07-01&rft.volume=17&rft.issue=7&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Age; hip fracture; osteoporosis; intervention; Gender; Liver; elderly; survival; lymphoma; Morbidity; Cancer ER - TY - JOUR T1 - Pseudoepitheliomatous hyperplasia - an unusual reaction following tattoo: report of a case and review of the literature AN - 20234099; 7902292 AB - A 59-year-old woman presented with an itchy and uncomfortable raised lesion at a tattoo site (Fig. 1) on the lateral aspect of the left leg, just above the ankle. The tattoo had been placed 2 years before her presentation and the tattoo site was sun exposed. Immediately after she had the tattoo, she noticed redness of the skin. After a week, a pruritic and red scaly nodule developed that continued to gradually enlarge until her presentation. The patient had tried topical vitamin A and D ointment with no relief. The patient also had tattoos on the arms without any noticeable skin changes. The patient reported that the tattoo procedure on her leg was more painful than that on her arms, and was performed by a different (and perhaps inexperienced) tattoo artist. The original tattoo contained red, green, and yellow pigments.A diagnosis of tattoo granuloma was considered; squamous cell carcinoma and fungal infection were included in the differential diagnosis. A punch biopsy was performed, followed by complete surgical excision of the lesion with a split-thickness skin graft from the right thigh.The skin excision specimen showed a 3 x 2.5-cm granular and pitted pink lesion with well-demarcated, somewhat irregular borders. The lesion was raised 0.5 cm above the skin surface. The lesion was present in the center of the original tattoo. Portions of the original tattoo with green and blue-green pigmentation were visible on either side of the lesion. No satellite lesions were identified.Microscopically, the raised lesion demonstrated striking pseudoepitheliomatous hyperplasia, with irregular acanthosis of the epidermis and follicular infundibula, hyperkeratosis, and parakeratosis (Fig. 2). Follicular plugging was present with keratin-filled cystic spaces. There was a brisk mononuclear inflammatory infiltrate in the dermis, composed primarily of lymphocytes, with admixed plasma cells and histiocytes. Giant cells were occasionally identified. Dermal pigment deposition was noted both within the lesion and in the surrounding skin, corresponding to the original tattoo. Variable dermal fibrosis was noted, with thick collagen bundles in some areas. There was no evidence of epidermal keratinocytic atypia, dyskeratosis, or increased suprabasal mitotic activity. Special stains (periodic acid-Schiff and acid-fast) for microorganisms were negative. JF - International Journal of Dermatology AU - Cui, Wei AU - McGregor, Douglas H AU - Stark, Steven P AU - Ulusarac, Ozlem AU - Mathur, Sharad C AD - From the Departments of Pathology and Laboratory Medicine, and Surgery, VA Medical Center, Kansas City, Missouri, and University of Kansas Medical Center, Kansas City, Kansas, sharad.mathur@med.va.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 743 EP - 745 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 46 IS - 7 SN - 0011-9059, 0011-9059 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Ointments KW - Fibrosis KW - Dyskeratosis KW - Arm KW - Biopsy KW - Stains KW - Lymphocytes KW - Infection KW - Nodules KW - Collagen KW - Sun KW - Ankle KW - Tattoos KW - Giant cells KW - Pigmentation KW - Dermis KW - Skin KW - squamous cell carcinoma KW - Granuloma KW - Satellites KW - Inflammation KW - Leg KW - Epidermis KW - Hyperplasia KW - Differential diagnosis KW - Case reports KW - Reviews KW - Vitamin A KW - Microorganisms KW - Plasma cells KW - A 01400:Soil Microbes KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20234099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Dermatology&rft.atitle=Pseudoepitheliomatous+hyperplasia+-+an+unusual+reaction+following+tattoo%3A+report+of+a+case+and+review+of+the+literature&rft.au=Cui%2C+Wei%3BMcGregor%2C+Douglas+H%3BStark%2C+Steven+P%3BUlusarac%2C+Ozlem%3BMathur%2C+Sharad+C&rft.aulast=Cui&rft.aufirst=Wei&rft.date=2007-07-01&rft.volume=46&rft.issue=7&rft.spage=743&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Dermatology&rft.issn=00119059&rft_id=info:doi/10.1111%2Fj.1365-4632.2007.03150.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ointments; Fibrosis; Dyskeratosis; Biopsy; Arm; Lymphocytes; Stains; Infection; Nodules; Collagen; Sun; Ankle; Tattoos; Giant cells; Pigmentation; Dermis; Skin; squamous cell carcinoma; Granuloma; Satellites; Inflammation; Leg; Epidermis; Hyperplasia; Differential diagnosis; Case reports; Vitamin A; Reviews; Microorganisms; Plasma cells DO - http://dx.doi.org/10.1111/j.1365-4632.2007.03150.x ER - TY - JOUR T1 - Detectable Troponin Levels Predict Poor Prognosis in Patients With Left Ventricular Dysfunction Undergoing Internal Defibrillator Implantation AN - 20034087; 8001796 AB - Introduction:Troponin levels have been demonstrated to predict mortality in patients with cardiomyopathy. Implantable cardiac defibrillator (ICD) devices have been demonstrated to improve survival. It is not clear if ICDs would mitigate the negative outcome predicted by elevated troponin levels.Methods:We collected baseline blood samples for troponin T (TnT) and creatinine kinase-MB fraction in consecutive patients immediately before successful pectoral transvenous ICD implant. Patients were followed for total mortality. For analysis, patients were grouped by TnT detectablility ( greater than or equal to 0.01 ng-mL).Results:Fifty-two men, aged 68 plus or minus 10 years, were studied. Mean ejection fraction was 29 plus or minus 12% and 65% had ischemic cardiomyopathy. Follow-up duration was 17 plus or minus 8 months. None of the patients had abnormal creatinine kinase-MB fraction levels (1.7 plus or minus 1.1 ng-mL). There were 37 patients with no detectable TnT (Group I) and 15 with detectable TnT (Group II). There was no difference between the two groups in terms of age (68 vs 69, P = NS), ejection fraction (30 vs 29%, P = NS), or proportion of patients with ischemic cardiomyopathy (68 vs 60%, P = NS). During follow-up 16 (31%) patients died. Patients in group I had mortality of 16% (6-37) compared to 67% mortality (10-15, P < 0.001) in group II. On multivariate analysis, detectable TnT remained an independent predictor of mortality (HR 4.5, CI 1.4-14.25, P = 0.01).Conclusion:In a cohort of patients with cardiomyopathy undergoing ICD implantation for standard clinical indications, presence of detectable TnT was associated with high mortality despite ICD implantation. TnT obtained before ICD implantation may be useful for risk stratification. JF - Pacing and Clinical Electrophysiology AU - Sonel, Ali F AU - Shalaby, Alaa AU - McConnell, Joseph P AU - Czarnecki, Tammy AU - Hogen, Scott AU - Zahid, Maliha AU - Amidi, Morteza AD - Departments of Cardiology, VA Pittsburgh Healthcare System and the University of Pittsburgh, Pittsburgh, Pennsylvania, Alaa.Shalaby@med.va.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 839 EP - 844 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 30 IS - 7 SN - 0147-8389, 0147-8389 KW - Biotechnology and Bioengineering Abstracts KW - implantable cardioverter defibrillator KW - troponins KW - risk stratification KW - cardiomyopathy KW - Heart KW - Mortality KW - Age KW - Troponin T KW - Troponin KW - Prognosis KW - Survival KW - Electrophysiology KW - Ischemia KW - Cardiomyopathy KW - Ventricle KW - Creatinine KW - Multivariate analysis KW - Defibrillators KW - Calcium-binding protein KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20034087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pacing+and+Clinical+Electrophysiology&rft.atitle=Detectable+Troponin+Levels+Predict+Poor+Prognosis+in+Patients+With+Left+Ventricular+Dysfunction+Undergoing+Internal+Defibrillator+Implantation&rft.au=Sonel%2C+Ali+F%3BShalaby%2C+Alaa%3BMcConnell%2C+Joseph+P%3BCzarnecki%2C+Tammy%3BHogen%2C+Scott%3BZahid%2C+Maliha%3BAmidi%2C+Morteza&rft.aulast=Sonel&rft.aufirst=Ali&rft.date=2007-07-01&rft.volume=30&rft.issue=7&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Pacing+and+Clinical+Electrophysiology&rft.issn=01478389&rft_id=info:doi/10.1111%2Fj.1540-8159.2007.00770.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Mortality; Age; Troponin T; Prognosis; Troponin; Survival; Ischemia; Electrophysiology; Cardiomyopathy; Ventricle; Creatinine; Multivariate analysis; Defibrillators; Calcium-binding protein DO - http://dx.doi.org/10.1111/j.1540-8159.2007.00770.x ER - TY - JOUR T1 - Exogenous Heat-Killed Escherichia coli Improves Alveolar Macrophage Activity and Reduces Pneumocystis carinii Lung Burden in Infant Mice AN - 19687807; 7462130 AB - Pneumocystis carinii is an opportunistic fungal pathogen that causes life-threatening pneumonia in immunocompromised individuals. Infants appear to be particularly susceptible to Pneumocystis pulmonary infections. We have previously demonstrated that there is approximately a 3-week delay in the clearance of Pneumocystis organisms from pup mouse lungs compared to that in adults. We have further shown that there is approximately a 1-week delay in alveolar macrophage activation in pups versus adult mice. Alveolar macrophages are the primary effector cells responsible for the killing and clearance of Pneumocystis, suggesting that pup alveolar macrophages may be involved in the delayed clearance of this organism. Alveolar macrophages cultured in vitro with Pneumocystis alone demonstrate little to no activation, as indicated by a lack of cytokine production. However, when cultured with lipopolysaccharide (LPS) or zymosan, cytokine production was markedly increased, suggesting that pup alveolar macrophages are specifically unresponsive to Pneumocystis organisms rather than being intrinsically unable to become activated. Furthermore, pup mice treated with aerosolized, heat-killed Escherichia coli in vivo were able to clear Pneumocystis more efficiently than were control mice. Together, these data suggest that while pup alveolar macrophages are unresponsive to P. carinii f. sp. muris organisms, they are capable of activation by heat-killed E. coli in vivo, as well as LPS and zymosan in vitro. The lack of response of pup mice to P. carinii f. sp. muris may reflect protective mechanisms specific to the developing pup lung, but ultimately it results in insufficient clearance of Pneumocystis organisms. JF - Infection and Immunity AU - Empey, Kerry M AU - Hollifield, Melissa AU - Garvy, Beth A AD - Departments of Microbiology, Immunology, and Molecular Genetics. Clinical Pharmaceutical Sciences. Internal Medicine, University of Kentucky Medical Center. Veterans Administration Medical Center, Lexington, Kentucky Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 3382 EP - 3393 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 7 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Pneumocystis carinii KW - Pathogens KW - Infection KW - Alveoli KW - Cell activation KW - Effector cells KW - Opportunist infection KW - Lung KW - Escherichia coli KW - Lipopolysaccharides KW - Cytokines KW - Pneumonia KW - Infants KW - K 03350:Immunology KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19687807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Exogenous+Heat-Killed+Escherichia+coli+Improves+Alveolar+Macrophage+Activity+and+Reduces+Pneumocystis+carinii+Lung+Burden+in+Infant+Mice&rft.au=Empey%2C+Kerry+M%3BHollifield%2C+Melissa%3BGarvy%2C+Beth+A&rft.aulast=Empey&rft.aufirst=Kerry&rft.date=2007-07-01&rft.volume=75&rft.issue=7&rft.spage=3382&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Lung; Cytokines; Lipopolysaccharides; Pathogens; Infection; Pneumonia; Alveoli; Opportunist infection; Effector cells; Infants; Cell activation; Pneumocystis carinii; Escherichia coli ER - TY - JOUR T1 - The Relationship Between Child Abuse and Adult Obesity Among California Women AN - 19657876; 8791308 AB - Abstract not available. JF - American Journal of Preventive Medicine AU - Alvarez, Jennifer AU - Pavao, Joanne AU - Baumrind, Nikki AU - Kimerling, Rachel AD - Center for Health Care Evaluation, VA Palo Alto Health Care System, Palo Alto, California, Jennifer.Alvarez@va.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 28 EP - 33 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 33 IS - 1 SN - 0749-3797, 0749-3797 KW - Physical Education Index; Risk Abstracts KW - Obesity KW - child abuse KW - Child abuse KW - Women KW - obesity KW - Females KW - USA, California KW - Adults KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19657876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=The+Relationship+Between+Child+Abuse+and+Adult+Obesity+Among+California+Women&rft.au=Alvarez%2C+Jennifer%3BPavao%2C+Joanne%3BBaumrind%2C+Nikki%3BKimerling%2C+Rachel&rft.aulast=Alvarez&rft.aufirst=Jennifer&rft.date=2007-07-01&rft.volume=33&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2007.02.036 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Adults; Obesity; Women; Child abuse; USA, California; obesity; child abuse; Females DO - http://dx.doi.org/10.1016/j.amepre.2007.02.036 ER - TY - JOUR T1 - Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction AN - 19669116; 7434275 AB - Matrix metalloproteinases (MMPs) are central to the development and progression of dysfunctional ventricular remodeling after tissue injury. We studied 6 month old heterozygous mice with cardiac-specific transgenic expression of active MMP-2 (MMP-2 Tg). MMP-2 Tg hearts showed no substantial gross alteration of cardiac phenotype compared to age-matched wild-type littermates. However, buffer perfused MMP-2 Tg hearts subjected to 30min of global ischemia followed by 30min of reperfusion had a larger infarct size and greater depression in contractile performance compared to wild-type hearts. Importantly, cardioprotection mediated by ischemic preconditioning (IPC) was completely abolished in MMP-2 Tg hearts, as shown by abnormalities in mitochondrial ultrastructure and impaired respiration, increased lipid peroxidation, cell necrosis and persistently reduced recovery of contractile performance during post-ischemic reperfusion. We conclude that MMP-2 functions not only as a proteolytic enzyme but also as a previously unrecognized active negative regulator of mitochondrial function during superimposed oxidative stress. JF - Biochemical and Biophysical Research Communications AU - Zhou, H Z AU - Ma, X AU - Gray, MO AU - Zhu, Bq AU - Nguyen AU - Baker, A J AU - Simonis, U AU - Cecchini, G AU - Lovett, D H AU - Karliner, J S AD - Department of Medicine, UCSF and VA Medical Center, 4150 Clement Street, 111C-5, San Francisco, CA 94121, USA, joel.karliner@va.gov Y1 - 2007/06/22/ PY - 2007 DA - 2007 Jun 22 SP - 189 EP - 195 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 358 IS - 1 SN - 0006-291X, 0006-291X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Heart KW - Muscle contraction KW - Depression KW - Injuries KW - Mitochondria KW - Matrix metalloproteinase KW - Ischemia KW - Transgenic mice KW - Lipid peroxidation KW - Reperfusion KW - Necrosis KW - Oxidative stress KW - Gelatinase A KW - Ultrastructure KW - Electron transport KW - Proteolytic enzymes KW - Heart diseases KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19669116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Transgenic+MMP-2+expression+induces+latent+cardiac+mitochondrial+dysfunction&rft.au=Zhou%2C+H+Z%3BMa%2C+X%3BGray%2C+MO%3BZhu%2C+Bq%3BNguyen%3BBaker%2C+A+J%3BSimonis%2C+U%3BCecchini%2C+G%3BLovett%2C+D+H%3BKarliner%2C+J+S&rft.aulast=Zhou&rft.aufirst=H&rft.date=2007-06-22&rft.volume=358&rft.issue=1&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2007.04.094 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Heart; Muscle contraction; Depression; Injuries; Matrix metalloproteinase; Mitochondria; Ischemia; Transgenic mice; Lipid peroxidation; Reperfusion; Necrosis; Oxidative stress; Gelatinase A; Electron transport; Ultrastructure; Proteolytic enzymes; Heart diseases DO - http://dx.doi.org/10.1016/j.bbrc.2007.04.094 ER - TY - JOUR T1 - The Words-in-Noise (WIN) test with multitalker babble and speech-spectrum noise maskers. AN - 85410719; pmid-17849640 AB - The Words-in-Noise (WIN) test uses monosyllabic words in seven signal-to-noise ratios of multitalker babble (MTB) to evaluate the ability of individuals to understand speech in background noise. The purpose of this study was to evaluate the criterion validity of the WIN by comparing recognition performances under MTB and speech-spectrum noise (SSN) using listeners with normal hearing and listeners with hearing loss. The MTB and SSN had identical rms and similar spectra but different amplitude-modulation characteristics. The performances by the listeners with normal hearing, which were 2 dB better in MTB than in SSN, were about 10 dB better than the performances by the listeners with hearing loss, which were about 0.5 dB better in MTB with 56% of the listeners better in MTB and 40% better in SSN. The slopes of the functions for the normal-hearing listeners (8-9%/dB) were steeper than the functions for the listeners with hearing loss (5-6%/dB). The data indicate that the WIN has good criterion validity. JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AU - Carnell, Crystal S AU - Cleghorn, Amber L AD - James H. Quillen VA Medical Center, Mountain Home, Tennessee 37684, USA. Richard.Wilson2@va.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 522 EP - 529 VL - 18 IS - 6 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Aged KW - Aged, 80 and over KW - Aging KW - Cochlea: physiopathology KW - Female KW - Hearing Loss, Sensorineural: diagnosis KW - Hearing Loss, Sensorineural: physiopathology KW - Hearing Loss, Sensorineural: therapy KW - Humans KW - Male KW - Middle Aged KW - *Noise: adverse effects KW - *Perceptual Masking KW - Recognition (Psychology) KW - Severity of Illness Index KW - *Speech Perception KW - *Vocabulary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85410719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=The+Words-in-Noise+%28WIN%29+test+with+multitalker+babble+and+speech-spectrum+noise+maskers.&rft.au=Wilson%2C+Richard+H%3BCarnell%2C+Crystal+S%3BCleghorn%2C+Amber+L&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2007-06-01&rft.volume=18&rft.issue=6&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: J Am Acad Audiol. 2007 Sep;18(8):718; author reply 718-9[18326157] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Expiratory Muscle Strength Training. Speech Production Outcomes in Patients with Multiple Sclerosis AN - 746305096; 12994403 AB - Purpose. This study investigated the effect of expiratory muscle strength training (EMST) on voice production, dysarthria, and voice-related quality-of-life issues in persons with multiple sclerosis (PwMS). It was hypothesized that PwMS would have improved voice production and reduced voice-related quality-of-life issues following EMST. Participants and Methods. Seventeen participants with MS and 14 healthy (H) controls completed 8 weeks of EMST, followed by 4 weeks of no training. Analyzed outcomes as a function of EMST were maximal expiratory pressure (MEP), sustained vowel prolongation (SVP), words per minute (WPM) measured from connected speech, and quality-of-life indices related to the presence of the dysarthria and dysphonia. Results. PwMS had lower MEPs, shorter SVP, and less WPM than the controls prior to training. Following EMST, both groups had significant improvement in MEPs that stayed above baseline after training halted. EMST did not improve voice production or voice-related quality of life for PwMS. Conclusion. Respiratory muscle weakness is present in PwMS having mild- to moderate-level disability. EMST improved expiratory muscle strength but did not statistically change objective and subjective components of voice/speech production in PwMS. JF - Neurorehabilitation and Neural Repair AU - Chiara, T AU - Martin, D AU - Sapienza, C AD - Malcom Randall VA Medical Center, Brain Rehabilitation Research Center, Gainesville, FL,, Department of Physical Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, toni.chiara@med.va.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 239 EP - 249 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 21 IS - 3 SN - 1545-9683, 1545-9683 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Handicapped KW - Measurement KW - Statistics KW - Rehabilitation KW - Multiple sclerosis KW - Muscles KW - Strength (training) KW - Lifestyle KW - speech KW - Analysis KW - Pressure KW - Speech KW - Muscular strength KW - Neurology KW - Quality of life KW - N3 11027:Neurology & neuropathology KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746305096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurorehabilitation+and+Neural+Repair&rft.atitle=Expiratory+Muscle+Strength+Training.+Speech+Production+Outcomes+in+Patients+with+Multiple+Sclerosis&rft.au=Chiara%2C+T%3BMartin%2C+D%3BSapienza%2C+C&rft.aulast=Chiara&rft.aufirst=T&rft.date=2007-06-01&rft.volume=21&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Neurorehabilitation+and+Neural+Repair&rft.issn=15459683&rft_id=info:doi/10.1177%2F1545968306294737 LA - English DB - Physical Education Index N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Measurement; Handicapped; Statistics; Multiple sclerosis; Analysis; Muscles; Speech; Strength (training); Lifestyle; speech; Rehabilitation; Pressure; Muscular strength; Quality of life; Neurology DO - http://dx.doi.org/10.1177/1545968306294737 ER - TY - JOUR T1 - Evaluation of epidermal growth factor receptor gene and chromosome 7 alterations in squamous cell carcinoma of the larynx, using chromogenic in situ hybridization on tissue microarrays. AN - 742773317; pmid-16882359 AB - AIMS: To identify subgroups of patients with squamous cell carcinoma (SCC) of the larynx, characterized by the specific deregulation mechanism of the epidermal growth factor receptor (EGFR) gene, and to evaluate EGFR protein expression levels and correlate these with biological and clinicopathological parameters. MATERIALS AND METHODS: Using tissue microarray technology, 50 formalin-fixed, paraffin-embedded primary laryngeal SCCs were cored and re-embedded into one block. Immunohistochemistry and chromogenic in situ hybridization were performed. RESULTS: Epidermal growth factor receptor protein over-expression was observed in 27/50 (54 per cent) cases and was statistically associated with tumour grade (p=0.028). Epidermal growth factor receptor gene alterations were identified in 5/50 (10 per cent) cases, which demonstrated amplification (n=4) and deletion (n=1). Chromosome 7 instability was detected in 8/50 (16 per cent) cases. CONCLUSIONS: Epidermal growth factor receptor over-expression is a frequent event in SCCs, but it does not predict a specific molecular mechanism of gene deregulation for targeted therapeutic strategies via monoclonal antibodies. JF - The Journal of laryngology and otology AU - Tsiambas, E AU - Stavrakis, I AU - Lazaris, A C AU - Karameris, A AU - Patsouris, E AD - Department of Pathology, 417 Veterans Administration Hospital (NIMTS), Athens, Greece. tsiambasecyto@yahoo.gr Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 563 EP - 570 VL - 121 IS - 6 SN - 0022-2151, 0022-2151 KW - National Library of Medicine KW - Image Interpretation, Computer-Assisted KW - Humans KW - In Situ Hybridization -- methods KW - Immunohistochemistry -- methods KW - Middle Aged KW - Tissue Array Analysis -- methods KW - Patient Selection KW - Male KW - Female KW - Laryngeal Neoplasms -- genetics KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- genetics KW - Genes, erbB-1 -- genetics KW - Laryngeal Neoplasms -- pathology KW - Chromosomes, Human, Pair 7 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742773317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laryngology+and+otology&rft.atitle=Evaluation+of+epidermal+growth+factor+receptor+gene+and+chromosome+7+alterations+in+squamous+cell+carcinoma+of+the+larynx%2C+using+chromogenic+in+situ+hybridization+on+tissue+microarrays.&rft.au=Tsiambas%2C+E%3BStavrakis%2C+I%3BLazaris%2C+A+C%3BKarameris%2C+A%3BPatsouris%2C+E&rft.aulast=Tsiambas&rft.aufirst=E&rft.date=2007-06-01&rft.volume=121&rft.issue=6&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laryngology+and+otology&rft.issn=00222151&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - PTSD symptoms, substance use, and vipassana meditation among incarcerated individuals. AN - 70702806; 17597132 AB - The present study evaluated whether Posttraumatic Stress Disorder (PTSD) symptom severity was associated with participation and treatment outcomes comparing a Vipassana meditation course to treatment as usual in an incarcerated sample. This study utilizes secondary data. The original study demonstrated that Vipassana meditation is associated with reductions in substance use. The present study found that PTSD symptom severity did not differ significantly between those who did and did not volunteer to take the course. Participation in the Vipassana course was associated with significantly greater reductions in substance use than treatment as usual, regardless of PTSD symptom severity levels. These results suggest that Vipassana meditation is worthy of further study for those with comorbid PTSD and substance use problems. JF - Journal of traumatic stress AU - Simpson, T L AU - Kaysen, D AU - Bowen, S AU - MacPherson, L M AU - Chawla, N AU - Blume, A AU - Marlatt, G A AU - Larimer, M AD - VA Puget Sound Health Care System and Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. tracey.simpson@va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 239 EP - 249 VL - 20 IS - 3 SN - 0894-9867, 0894-9867 KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Recurrence KW - Male KW - Female KW - Comorbidity KW - Rehabilitation Centers KW - Alcoholism -- rehabilitation KW - Substance-Related Disorders -- diagnosis KW - Stress Disorders, Post-Traumatic -- rehabilitation KW - Stress Disorders, Post-Traumatic -- psychology KW - Alcoholism -- diagnosis KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Meditation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Prisoners -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70702806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+traumatic+stress&rft.atitle=PTSD+symptoms%2C+substance+use%2C+and+vipassana+meditation+among+incarcerated+individuals.&rft.au=Simpson%2C+T+L%3BKaysen%2C+D%3BBowen%2C+S%3BMacPherson%2C+L+M%3BChawla%2C+N%3BBlume%2C+A%3BMarlatt%2C+G+A%3BLarimer%2C+M&rft.aulast=Simpson&rft.aufirst=T&rft.date=2007-06-01&rft.volume=20&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Journal+of+traumatic+stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-16 N1 - Date created - 2007-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Emotional reactivity to trauma stimuli and duration of past smoking cessation attempts in smokers with posttraumatic stress disorder. AN - 70617596; 17563212 AB - The present study examined whether reactivity to emotional stressors is related to early relapse from smoking cessation in persons with posttraumatic stress disorder (PTSD). Smokers with PTSD who had failed to sustain any previous quit attempt for 7 days (n=26) and PTSD smokers who were able to sustain a quit attempt for more than a week (n=50) were exposed to emotional stimuli in the form of personalized scripts that included neutral/relaxing experiences, stressful/nontraumatic experiences, and traumatic experiences. Results indicated an interaction between script type and group. Although groups did not differ after presentation of neutral scripts, persons with PTSD unable to sustain a quit attempt for as long as 7 days responded with greater levels of emotional reactivity to both stressful and trauma stimuli relative to those able to sustain a quit attempt longer than 7 days. Further, results suggested that emotional reactivity to stressors (both traumatic and nontraumatic) is related to duration of past longest quit attempt in smokers with PTSD. Results are consistent with findings in nonpsychiatric samples that suggest that individual differences in affective regulatory processes are related to duration of smoking cessation attempts. Systematic replications including a prospective design are recommended. (c) 2007 APA, all rights reserved JF - Experimental and clinical psychopharmacology AU - Calhoun, Patrick S AU - Dennis, Michelle F AU - Beckham, Jean C AD - Veterans Affairs Medical Center, Durham, NC 27705, USA. Patrick.calhoun2@va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 256 EP - 263 VL - 15 IS - 3 SN - 1064-1297, 1064-1297 KW - Index Medicus KW - Humans KW - Adult KW - Time Factors KW - Recurrence KW - Male KW - Female KW - Stress, Psychological -- psychology KW - Smoking Cessation -- psychology KW - Stress Disorders, Post-Traumatic -- psychology KW - Affective Symptoms -- psychology KW - Tobacco Use Disorder -- psychology KW - Smoking -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70617596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Emotional+reactivity+to+trauma+stimuli+and+duration+of+past+smoking+cessation+attempts+in+smokers+with+posttraumatic+stress+disorder.&rft.au=Calhoun%2C+Patrick+S%3BDennis%2C+Michelle+F%3BBeckham%2C+Jean+C&rft.aulast=Calhoun&rft.aufirst=Patrick&rft.date=2007-06-01&rft.volume=15&rft.issue=3&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-17 N1 - Date created - 2007-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mortality and cancer incidence among tire manufacturing workers hired in or after 1962. AN - 70617592; 17563612 AB - This study evaluated mortality during 1962 through 2003 and cancer incidence during 1995 through 2003 at a tire manufacturing plant. The mortality study included 3425 men and women, employed for at least one year. Of these, 3069 were eligible for the cancer incidence study. Employees experienced 390 deaths compared with 608 expected (standardized mortality ratio (SMR)=64; 95% confidence interval (CI)=58-71). Total cancer mortality (123 observed, SMR=75, CI=62-89) and lung cancer mortality (47 observed, SMR=72, CI=53-96) were lower than expected. Hourly white men had small increases in stomach cancer, bladder cancer, and leukemia deaths. During 1995 through 2003, 169 incident cancers were observed compared with 197 expected (SIR=86, 95% CI=74-100). Three mesothelioma cases occurred among hourly white men (SIR=653, CI=135-1907); all were exposed potentially to asbestos before starting at the rubber plant. Small numbers and limited information on jobs, occupational agents, and lifestyle preclude attribution of observed increases to workplace exposures. JF - Journal of occupational and environmental medicine AU - Beall, Colleen AU - Corn, Morton AU - Cheng, Hong AU - Matthews, Robert AU - Delzell, Elizabeth AD - Department of Epidemiology, University of Alabama at Birmingham, Bermingham, AL 35294-0022, USA. colleen.beall2@va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 680 EP - 690 VL - 49 IS - 6 SN - 1076-2752, 1076-2752 KW - Rubber KW - 9006-04-6 KW - Index Medicus KW - Registries KW - Employment -- statistics & numerical data KW - Texas -- epidemiology KW - Humans KW - Adult KW - Incidence KW - Confidence Intervals KW - Middle Aged KW - Male KW - Female KW - Neoplasms -- mortality KW - Neoplasms -- epidemiology KW - Occupational Exposure -- adverse effects KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70617592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Mortality+and+cancer+incidence+among+tire+manufacturing+workers+hired+in+or+after+1962.&rft.au=Beall%2C+Colleen%3BCorn%2C+Morton%3BCheng%2C+Hong%3BMatthews%2C+Robert%3BDelzell%2C+Elizabeth&rft.aulast=Beall&rft.aufirst=Colleen&rft.date=2007-06-01&rft.volume=49&rft.issue=6&rft.spage=680&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-19 N1 - Date created - 2007-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. AN - 70592593; 17570226 AB - Primary liver cancer, which consists predominantly of hepatocellular carcinoma (HCC), is the fifth most common cancer worldwide and the third most common cause of cancer mortality. HCC has several interesting epidemiologic features including dynamic temporal trends; marked variations among geographic regions, racial and ethnic groups, and between men and women; and the presence of several well-documented environmental potentially preventable risk factors. Moreover, there is a growing understanding on the molecular mechanisms inducing hepatocarcinogenesis, which almost never occurs in healthy liver, but the cancer risk increases sharply in response to chronic liver injury at the cirrhosis stage. A detailed understanding of epidemiologic factors and molecular mechanisms associated with HCC ultimately could improve our current concepts for screening and treatment of this disease. JF - Gastroenterology AU - El-Serag, Hashem B AU - Rudolph, K Lenhard AD - Michael E. DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Houston, Texas, USA. hasheme@bcm.tmc.edu Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 2557 EP - 2576 VL - 132 IS - 7 SN - 0016-5085, 0016-5085 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Global Health KW - Liver Diseases -- complications KW - Risk Factors KW - Humans KW - Continental Population Groups KW - Incidence KW - Liver Cirrhosis -- complications KW - Sex Distribution KW - Diabetes Complications KW - Obesity -- complications KW - Age Distribution KW - Carcinoma, Hepatocellular -- etiology KW - Carcinoma, Hepatocellular -- genetics KW - Liver Neoplasms -- epidemiology KW - Carcinoma, Hepatocellular -- epidemiology KW - Carcinoma, Hepatocellular -- chemically induced KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70592593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Hepatocellular+carcinoma%3A+epidemiology+and+molecular+carcinogenesis.&rft.au=El-Serag%2C+Hashem+B%3BRudolph%2C+K+Lenhard&rft.aulast=El-Serag&rft.aufirst=Hashem&rft.date=2007-06-01&rft.volume=132&rft.issue=7&rft.spage=2557&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-24 N1 - Date created - 2007-06-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical evaluation of the nelfinavir-rifabutin interaction in patients with tuberculosis and human immunodeficiency virus infection. AN - 70579706; 17542762 AB - To characterize the bidirectional interaction between twice-daily nelfinavir and twice-weekly rifabutin and isoniazid in patients with tuberculosis and human immunodeficiency virus (HIV) infection. Prospective cohort study. Three clinical research centers. Seven patients with HIV-related tuberculosis. Rifabutin 300 mg and isoniazid 15 mg/kg (maximum dose 900 mg) twice/week were administered for at least 2 weeks during the continuation phase of tuberculosis treatment. Antiretroviral therapy with nelfinavir 1250 mg twice/day and two nucleoside reverse transcriptase inhibitors was then added. Patients underwent blood sampling for pharmacokinetic analysis during the continuation phase of tuberculosis therapy and after a median of 21 days after the addition of antiretroviral treatment. When rifabutin was coadministered with nelfinavir, its area under the concentration-time curve from 0-21 hours (AUC(0-21)) increased 22% (geometric mean 5.01 microg.hr/ml [90% confidence interval (CI) 3.25-7.71] with nelfinavir vs 4.10 microg.hr/ml [90% CI 3.18-5.27] without nelfinavir; geometric mean ratio 1.22 [90% CI 0.78-1.92]). Also, the AUC(0-21) for the active metabolite, desacetylrifabutin, increased significantly (geometric mean ratio 3.46, 90% CI 1.84-6.47, p=0.009). In the presence of rifabutin, the pharmacokinetic parameters of nelfinavir and its principal metabolite M8 were similar to those of patients not taking rifabutin. No drug interaction between nelfinavir and isoniazid was detected. Coadministration of rifabutin and isoniazid without dosage adjustment during twice-weekly tuberculosis therapy with nelfinavir-based antiretroviral therapy resulted in rifabutin exposures within the acceptable ranges for safety and efficacy. Therefore, this combination is an appropriate option for the simultaneous treatment of tuberculosis and HIV infection when tuberculosis therapy is given twice weekly. JF - Pharmacotherapy AU - Benator, Debra A AU - Weiner, Marc H AU - Burman, William J AU - Vernon, Andrew A AU - Zhao, Zhen A AU - Khan, Awal E AU - Jones, Brenda E AU - Sandman, Laurie AU - Engle, Melissa AU - Silva-Trigo, Claudia AU - Hsyu, Poe H AU - Becker, Mark I AU - Peloquin, Charles A AU - Tuberculosis Trials Consortium AD - Division of Infectious Diseases, Veterans Affairs Medical Center, Washington, D.C. 20422, USA. debra.benator@med.va.gov ; Tuberculosis Trials Consortium Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 793 EP - 800 VL - 27 IS - 6 SN - 0277-0008, 0277-0008 KW - Antibiotics, Antitubercular KW - 0 KW - Antitubercular Agents KW - HIV Protease Inhibitors KW - hydroxy-t-butylamidenelfinavir KW - 25-desacetylrifabutin KW - 100324-63-8 KW - Rifabutin KW - 1W306TDA6S KW - Nelfinavir KW - HO3OGH5D7I KW - Isoniazid KW - V83O1VOZ8L KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Interactions KW - Prospective Studies KW - Isoniazid -- therapeutic use KW - Area Under Curve KW - Humans KW - Cohort Studies KW - Male KW - Female KW - Antitubercular Agents -- therapeutic use KW - Rifabutin -- adverse effects KW - Rifabutin -- blood KW - Rifabutin -- analogs & derivatives KW - Nelfinavir -- analogs & derivatives KW - Tuberculosis -- drug therapy KW - Nelfinavir -- blood KW - Antibiotics, Antitubercular -- adverse effects KW - Antibiotics, Antitubercular -- therapeutic use KW - Nelfinavir -- pharmacokinetics KW - HIV Protease Inhibitors -- therapeutic use KW - Nelfinavir -- therapeutic use KW - Rifabutin -- therapeutic use KW - Nelfinavir -- adverse effects KW - Tuberculosis -- complications KW - HIV Infections -- complications KW - HIV Infections -- drug therapy KW - HIV Protease Inhibitors -- pharmacokinetics KW - Rifabutin -- pharmacokinetics KW - HIV Protease Inhibitors -- adverse effects KW - Antibiotics, Antitubercular -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70579706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Clinical+evaluation+of+the+nelfinavir-rifabutin+interaction+in+patients+with+tuberculosis+and+human+immunodeficiency+virus+infection.&rft.au=Benator%2C+Debra+A%3BWeiner%2C+Marc+H%3BBurman%2C+William+J%3BVernon%2C+Andrew+A%3BZhao%2C+Zhen+A%3BKhan%2C+Awal+E%3BJones%2C+Brenda+E%3BSandman%2C+Laurie%3BEngle%2C+Melissa%3BSilva-Trigo%2C+Claudia%3BHsyu%2C+Poe+H%3BBecker%2C+Mark+I%3BPeloquin%2C+Charles+A%3BTuberculosis+Trials+Consortium&rft.aulast=Benator&rft.aufirst=Debra&rft.date=2007-06-01&rft.volume=27&rft.issue=6&rft.spage=793&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-03 N1 - Date created - 2007-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effectiveness and hepatotoxicity of statins in men seropositive for hepatitis C virus. AN - 70577530; 17542767 AB - To evaluate the effectiveness and hepatotoxicity of statins in patients who are seropositive for hepatitis C virus (HCV). Retrospective review of a registry of patients with HCV. Veterans Affairs Medical Center. One hundred forty-six male patients who were seropositive for HCV and had received statin therapy between January 1, 1995, and September 9, 2003. Demographic and clinical data were collected for each patient; lipid and alanine aminotransferase (ALT) levels at baseline (within 6 mo of starting a statin), at 3 and 6 months after starting a statin, and at long-term follow-up (mean 22 mo) were also recorded. The primary efficacy end point was a significant decrease from baseline to long-term follow-up low-density lipoprotein cholesterol (LDL) level; the primary safety end point was a significant increase from baseline in ALT level. The mean change in LDL level was a reduction of 22% (p<0.01). No significant increases in ALT levels were observed; only one patient discontinued therapy due to ALT level elevations greater than 3 times the upper limit of normal. In men seropositive for HCV, statins were effective in reducing LDL levels and did not result in significant increases in ALT levels from baseline. Thus, statin therapy should be considered for patients with HCV who are at risk for coronary heart disease and do not have significantly elevated serum transaminase levels at baseline. JF - Pharmacotherapy AU - Segarra-Newnham, Marisel AU - Parra, David AU - Martin-Cooper, Ellen M AD - Pharmacy Department, Patient Support Service, Veterans Affairs Medical Center, West Palm Beach, Florida 33410-6400, USA. marisel.segarra-newnham@med.va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 845 EP - 851 VL - 27 IS - 6 SN - 0277-0008, 0277-0008 KW - Cholesterol, LDL KW - 0 KW - Hepatitis C Antibodies KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Cholesterol, LDL -- blood KW - Alanine Transaminase -- blood KW - Coronary Disease -- prevention & control KW - Cholesterol, LDL -- drug effects KW - Humans KW - Hepatitis C Antibodies -- blood KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Liver Function Tests KW - Alanine Transaminase -- drug effects KW - Male KW - Hospitals, Veterans KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Liver -- drug effects KW - Hepatitis C -- complications KW - Hypercholesterolemia -- complications KW - Chemical and Drug Induced Liver Injury KW - Liver -- metabolism KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- therapeutic use KW - Hypercholesterolemia -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70577530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Effectiveness+and+hepatotoxicity+of+statins+in+men+seropositive+for+hepatitis+C+virus.&rft.au=Segarra-Newnham%2C+Marisel%3BParra%2C+David%3BMartin-Cooper%2C+Ellen+M&rft.aulast=Segarra-Newnham&rft.aufirst=Marisel&rft.date=2007-06-01&rft.volume=27&rft.issue=6&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-03 N1 - Date created - 2007-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of problem alcohol use on patient behavior and caregiver burden in a geriatric assessment clinic. AN - 70573182; 17548783 AB - There has been a growing interest in understanding issues surrounding alcohol use in late life. Information about the relationship of alcohol use to behavioral problems in older persons living in the community is particularly limited. This study used information obtained from an outpatient geriatric assessment clinic to study this relationship and the effects of these behaviors on caregivers. Data on alcohol use, problem behaviors, and caregiver burden were collected prospectively in consecutive patients undergoing geriatric assessment primarily for cognitive problems over a 3-year period. All patients were evaluated by a multidisciplinary team, which included a geriatric psychiatrist. The evaluation screened for current and/or past alcohol use through interviews with the patient and a collateral source. The collateral source also completed the Neuropsychiatric Inventory and the Family Burden Scale. Subjects were classified into 2 groups: those with a current or past alcohol problem and those with no alcohol problem. A total of 349 patients were evaluated, with 17.8% being designated as having a current or past alcohol problem. This subgroup represented 35% of the men and 9% of the women from the study population. Approximately half of the subgroup was actively drinking alcohol. Patients with a history of problem alcohol use, regardless of current use and cognitive status, exhibited more behavioral disturbances including agitation, irritability, and disinhibition. Their caregivers reported significantly higher caregiver distress. Current or past alcohol problem use was frequent in this population of frail, older adults undergoing geriatric assessment. Regardless of current alcohol use, these patients displayed more behavioral disturbances than those without a history of problem drinking, and their caregivers experienced significantly more burden. A history of problem drinking appears to be a significant marker for behavioral disturbances in late life and merits further study. JF - Journal of geriatric psychiatry and neurology AU - Sattar, S Pirzada AU - Padala, Prasad R AU - McArthur-Miller, Delores AU - Roccaforte, William H AU - Wengel, Steven P AU - Burke, William J AD - Substance Abuse Treatment Program, Omaha VA Medical Center, Nebraska, USA. syed.sattar@med.va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 120 EP - 127 VL - 20 IS - 2 SN - 0891-9887, 0891-9887 KW - Index Medicus KW - Age Factors KW - Sex Factors KW - Aged, 80 and over KW - Humans KW - Mental Status Schedule KW - Aged KW - Middle Aged KW - Male KW - Female KW - Comorbidity KW - Mental Disorders -- diagnosis KW - Alzheimer Disease -- epidemiology KW - Cost of Illness KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Mental Disorders -- epidemiology KW - Alzheimer Disease -- psychology KW - Mental Disorders -- psychology KW - Geriatric Assessment KW - Alcoholism -- psychology KW - Caregivers -- psychology KW - Alzheimer Disease -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70573182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+geriatric+psychiatry+and+neurology&rft.atitle=Impact+of+problem+alcohol+use+on+patient+behavior+and+caregiver+burden+in+a+geriatric+assessment+clinic.&rft.au=Sattar%2C+S+Pirzada%3BPadala%2C+Prasad+R%3BMcArthur-Miller%2C+Delores%3BRoccaforte%2C+William+H%3BWengel%2C+Steven+P%3BBurke%2C+William+J&rft.aulast=Sattar&rft.aufirst=S&rft.date=2007-06-01&rft.volume=20&rft.issue=2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Journal+of+geriatric+psychiatry+and+neurology&rft.issn=08919887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-17 N1 - Date created - 2007-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thiazolidinedione treatment decreases bone mineral density in type 2 diabetic men. AN - 70562080; 17363747 JF - Diabetes care AU - Yaturu, Subhashini AU - Bryant, Barbara AU - Jain, Sushil K AD - Department of Endocrinology, Overton Brooks VA Medical Center, Shreveport, Louisiana 71101-4295, USA. subhashini.yaturu@med.va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1574 EP - 1576 VL - 30 IS - 6 KW - Hypoglycemic Agents KW - 0 KW - Thiazolidinediones KW - rosiglitazone KW - 05V02F2KDG KW - 2,4-thiazolidinedione KW - AA68LXK93C KW - Index Medicus KW - Fractures, Bone -- epidemiology KW - Risk Factors KW - Humans KW - Male KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Bone Density -- drug effects KW - Bone Resorption -- chemically induced KW - Thiazolidinediones -- adverse effects KW - Hypoglycemic Agents -- adverse effects KW - Diabetes Mellitus, Type 2 -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70562080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=Thiazolidinedione+treatment+decreases+bone+mineral+density+in+type+2+diabetic+men.&rft.au=Yaturu%2C+Subhashini%3BBryant%2C+Barbara%3BJain%2C+Sushil+K&rft.aulast=Yaturu&rft.aufirst=Subhashini&rft.date=2007-06-01&rft.volume=30&rft.issue=6&rft.spage=1574&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=1935-5548&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-13 N1 - Date created - 2007-05-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Diabetes Care. 2007 Jun;30(6):1670-1 [17526825] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Patient and provider perceptions of hypertension treatment: do they agree? AN - 70560542; 17541326 AB - The objective of our study was to explore physician and patient attitudes regarding hypertension management. One hundred forty-five primary care providers and 189 patients with hypertension at 6 Veterans Administration clinics completed a hypertension survey. Fifty-one percent of patients were at their blood pressure goal, 58% were on guideline-concordant therapy, and 31% achieved both. Patients and providers agreed that physicians were a "very/extremely" useful source of information but differed in perceived value of pharmacists, educational material, advertising, and the Internet. They also agreed on the value of preventing cardiovascular events but differed in their perceptions of the importance of medication costs, side effects, and national guidelines. Blood pressure control and guideline-concordant therapy was higher than most prior reports, but with opportunity for improvement. Patients and providers differed in perceived value of various aspects of hypertension management; this information may help to determine trial design and quality improvement strategies in the future. JF - Journal of clinical hypertension (Greenwich, Conn.) AU - Kaboli, Peter J AU - Shivapour, Daniel M AU - Henderson, Michael S AU - Barnett, Mitchell J AU - Ishani, Areef AU - Carter, Barry L AD - Center for Research in the Implementation of Innovative Strategies in Practice (CSIISP) at the Iowa City Veterans Affairs Healthcare Systems, Iowa City, IA 52246, USA. peter.kaboli@va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 416 EP - 423 VL - 9 IS - 6 SN - 1524-6175, 1524-6175 KW - Antihypertensive Agents KW - 0 KW - Index Medicus KW - Minnesota KW - Antihypertensive Agents -- economics KW - Attitude to Health KW - Humans KW - Antihypertensive Agents -- adverse effects KW - Aged KW - Iowa KW - Cardiovascular Diseases -- prevention & control KW - Patient Compliance KW - Patient Education as Topic -- trends KW - Health Surveys KW - Antihypertensive Agents -- therapeutic use KW - Middle Aged KW - Blood Pressure -- drug effects KW - Male KW - Female KW - Hospitals, Veterans KW - Hypertension -- physiopathology KW - Patient Satisfaction KW - Health Knowledge, Attitudes, Practice KW - Physician-Patient Relations KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70560542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+hypertension+%28Greenwich%2C+Conn.%29&rft.atitle=Patient+and+provider+perceptions+of+hypertension+treatment%3A+do+they+agree%3F&rft.au=Kaboli%2C+Peter+J%3BShivapour%2C+Daniel+M%3BHenderson%2C+Michael+S%3BBarnett%2C+Mitchell+J%3BIshani%2C+Areef%3BCarter%2C+Barry+L&rft.aulast=Kaboli&rft.aufirst=Peter&rft.date=2007-06-01&rft.volume=9&rft.issue=6&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+hypertension+%28Greenwich%2C+Conn.%29&rft.issn=15246175&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-12 N1 - Date created - 2007-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Physiologic and pathophysiologic roles of lipid mediators in the kidney. AN - 70546398; 17361113 AB - Small lipids such as eicosanoids exert diverse and complex functions. In addition to their role in regulating normal kidney function, these lipids also play important roles in the pathogenesis of kidney diseases. Cyclooxygenase (COX)-derived prostanoids play important role in maintaining renal function, body fluid homeostasis, and blood pressure. Renal cortical COX2-derived prostanoids, particularly (PGI2) and PGE2 play critical roles in maintaining blood pressure and renal function in volume contracted states. Renal medullary COX2-derived prostanoids appear to have antihypertensive effect in individuals challenged with a high salt diet. 5-Lipoxygenase (LO)-derived leukotrienes are involved in inflammatory glomerular injury. LO product 12-hydroxyeicosatetraenoic acid (12-HETE) is associated with pathogenesis of hypertension, and may mediate angiotensin II and TGFbeta induced mesengial cell abnormality in diabetic nephropathy. P450 hydroxylase-derived 20-HETE is a potent vasoconstrictor and is involved in the pathogenesis of hypertension. P450 epoxygenase derived epoxyeicosatrienoic acids (EETs) have vasodilator and natriuretic effect. Blockade of EET formation is associated with salt-sensitive hypertension. Ceramide has also been demonstrated to be an important signaling molecule, which is involved in pathogenesis of acute kidney injury caused by ischemia/reperfusion, and toxic insults. Those pathways should provide fruitful targets for intervention in the pharmacologic treatment of renal disease. JF - Kidney international AU - Hao, C-M AU - Breyer, M D AD - Division of Nephrology, Department of Medicine, Vanderbilt University, Veterans Administration Medical Center, Nashville, Tennessee 37232, USA. chuanming.hao@vanderbilt.edu Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1105 EP - 1115 VL - 71 IS - 11 SN - 0085-2538, 0085-2538 KW - Arachidonic Acids KW - 0 KW - Ceramides KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - Cyclooxygenase 2 KW - Index Medicus KW - Animals KW - Blood Pressure KW - Cyclooxygenase 1 -- metabolism KW - Humans KW - Cytochrome P-450 Enzyme System -- metabolism KW - Ceramides -- metabolism KW - Cyclooxygenase 2 -- metabolism KW - Models, Biological KW - Hypertension -- metabolism KW - Kidney -- metabolism KW - Kidney -- physiology KW - Kidney -- enzymology KW - Arachidonic Acids -- metabolism KW - Arachidonic Acids -- chemistry KW - Kidney -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70546398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Physiologic+and+pathophysiologic+roles+of+lipid+mediators+in+the+kidney.&rft.au=Hao%2C+C-M%3BBreyer%2C+M+D&rft.aulast=Hao&rft.aufirst=C-M&rft.date=2007-06-01&rft.volume=71&rft.issue=11&rft.spage=1105&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-03 N1 - Date created - 2007-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury. AN - 70525351; 17428293 AB - L-Buthionine (S,R) sulfoximine (BSO) is an inhibitor of glutathione biosynthesis and has been used as an effective means of depleting glutathione from cells and tissues. Here we investigated whether treatment with BSO enhanced ethanol-induced liver injury in mice. Female C57Bl/6 mice were pair fed with control and ethanol-containing liquid diets in which ethanol was 29.2% of total calories. During the final 7 days of pair feeding, groups of control-fed and ethanol-fed mice were given 0, 5 or 7.6 mM BSO in the liquid diets. Compared with controls, ethanol given alone decreased total liver glutathione. This effect was exacerbated in mice given ethanol with 7.6 mM BSO, causing a 72% decline in hepatic glutathione. While ethanol alone caused no decrease in mitochondrial glutathione, inclusion of 7.6 mM BSO caused a 2-fold decline compared with untreated controls. L-Buthionine (S,R) sulfoximine did not affect ethanol consumption, but serum ethanol levels in BSO-treated mice were nearly 6-fold lower than in mice given ethanol alone. The latter decline in serum ethanol was associated with a significant elevation in the specific activities of cytochrome P450 2E1 and alcohol dehydrogenase in livers of BSO-treated animals. Ethanol consumption caused a 3.5-fold elevation in serum alanine aminotransferase levels but the enzyme fell to control levels when BSO was included in the diet. L-Buthionine (S,R) sulfoximine administration also attenuated ethanol-induced steatosis, prevented the leakage of lysosomal cathepsins into the cytosol, and prevented the ethanol-elicited decline in proteasome activity. L-Buthionine (S,R) sulfoximine, administered with ethanol, significantly depleted hepatic glutathione, compared with controls. However, despite the decrease in hepatic antioxidant levels, liver injury by ethanol was alleviated, due, in part, to a BSO-elicited acceleration of ethanol metabolism. JF - Alcoholism, clinical and experimental research AU - Donohue, Terrence M AU - Curry-McCoy, Tiana V AU - Todero, Sandra L AU - White, Ronda L AU - Kharbanda, Kusum K AU - Nanji, Amin A AU - Osna, Natalia A AD - Liver Study Unit, U.S. Department of Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA. tdonohue@unmc.edu Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1053 EP - 1060 VL - 31 IS - 6 SN - 0145-6008, 0145-6008 KW - Antimetabolites, Antineoplastic KW - 0 KW - Buthionine Sulfoximine KW - 5072-26-4 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Female KW - Liver -- drug effects KW - Alcohol Drinking -- adverse effects KW - Buthionine Sulfoximine -- pharmacology KW - Glutathione -- drug effects KW - Antimetabolites, Antineoplastic -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70525351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=L-Buthionine+%28S%2CR%29+sulfoximine+depletes+hepatic+glutathione+but+protects+against+ethanol-induced+liver+injury.&rft.au=Donohue%2C+Terrence+M%3BCurry-McCoy%2C+Tiana+V%3BTodero%2C+Sandra+L%3BWhite%2C+Ronda+L%3BKharbanda%2C+Kusum+K%3BNanji%2C+Amin+A%3BOsna%2C+Natalia+A&rft.aulast=Donohue&rft.aufirst=Terrence&rft.date=2007-06-01&rft.volume=31&rft.issue=6&rft.spage=1053&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-14 N1 - Date created - 2007-05-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal. AN - 70474058; 17297634 AB - Corticotropin-releasing factor (CRF) is the primary physiologic regulator of the hypothalamic-pituitary-adrenal (HPA) axis and serves to globally coordinate the mammalian stress response. Hyperactivity of central nervous system CRF neurotransmission, acting primarily via the CRF(1) receptor, has been strongly implicated in the pathophysiology of depression and anxiety. Furthermore, there is evidence of enhanced CRF transcription, release, and neuronal activity after the administration of and withdrawal from several drugs of abuse, including cannabis, cocaine, ethanol, and morphine. Treatment with CRF antagonists has been demonstrated to reduce the severity of certain drug withdrawal symptoms, implicating a specific role for activation of CRF neurons in mediating the anxiogenic and stress-like reactions observed after abrupt drug discontinuation. To extend these findings, we investigated whether pretreatment with the selective CRF(1) receptor antagonist R121919 decreases the behavioral and neuroendocrine activation observed after the precipitation of benzodiazepine (BZ) withdrawal in BZ-dependent rats. Pretreatment with R121919 attenuated the subsequent HPA axis activation, behavioral measures of anxiety, and expression of the CRF gene in the paraventricular nucleus of the hypothalamus, as measured by CRF heteronuclear RNA, which occurs after flumazenil-precipitation of withdrawal from the BZ, lorazepam. These results indicate that the activation of CRF neuronal systems may be a common neurobiological mechanism in withdrawal from drugs of abuse and moreover, that the CRF(1) receptor subtype plays a major role in mediating the effects of CRF on neuroendocrine and behavioral responses during BZ withdrawal. Therefore, CRF(1) receptor antagonists may be of therapeutic utility in the treatment of drug withdrawal syndromes. JF - Psychopharmacology AU - Skelton, Kelly H AU - Gutman, David A AU - Thrivikraman, K V AU - Nemeroff, Charles B AU - Owens, Michael J AD - Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA. kelly.skelton@va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 385 EP - 396 VL - 192 IS - 3 SN - 0033-3158, 0033-3158 KW - Anti-Anxiety Agents KW - 0 KW - Hypnotics and Sedatives KW - Pyrimidines KW - R 121919 KW - RNA, Heterogeneous Nuclear KW - Receptors, Corticotropin-Releasing Hormone KW - Flumazenil KW - 40P7XK9392 KW - Lorazepam KW - O26FZP769L KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Neurons -- metabolism KW - Hypothalamo-Hypophyseal System -- physiopathology KW - Anxiety -- drug therapy KW - Anxiety -- physiopathology KW - Stress, Physiological -- physiopathology KW - Rats KW - Behavior, Animal -- drug effects KW - Paraventricular Hypothalamic Nucleus -- metabolism KW - Rats, Sprague-Dawley KW - Pituitary-Adrenal System -- physiopathology KW - Substance-Related Disorders KW - RNA, Heterogeneous Nuclear -- metabolism KW - Stress, Physiological -- drug therapy KW - Male KW - Substance Withdrawal Syndrome -- physiopathology KW - Anti-Anxiety Agents -- adverse effects KW - Substance Withdrawal Syndrome -- drug therapy KW - Pyrimidines -- pharmacology KW - Receptors, Corticotropin-Releasing Hormone -- antagonists & inhibitors KW - Hypnotics and Sedatives -- adverse effects KW - Lorazepam -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70474058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=The+CRF1+receptor+antagonist+R121919+attenuates+the+neuroendocrine+and+behavioral+effects+of+precipitated+lorazepam+withdrawal.&rft.au=Skelton%2C+Kelly+H%3BGutman%2C+David+A%3BThrivikraman%2C+K+V%3BNemeroff%2C+Charles+B%3BOwens%2C+Michael+J&rft.aulast=Skelton&rft.aufirst=Kelly&rft.date=2007-06-01&rft.volume=192&rft.issue=3&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-09 N1 - Date created - 2007-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Self-medication hypothesis of substance use: testing Khantzian's updated theory. AN - 68171627; 17703709 AB - Substance use research has been a salient focus for mental health professionals in recent years. Several organizations, including the American Psychological Association, have been pressing for more substance use research, particularly clinically relevant, theory-based investigations. However, there are few theories of substance use, and even fewer with scientific support. One theory is the Self Medication Hypothesis by Khantzian (1977, 1974), a theory with 30 years of research. However, recent modifications in Khantzian's theory (1999) have not been properly tested. Specifically, two areas require further investigation: Khantzian's belief that more negative affect should be related directly to more substance use, and expanding the number of affective states examined, including alexithymia, to better operationalize Khantzian's belief that several painful and ambiguous forms of affect may be implicated in the self-medicating process. The current study assessed anxiety, depression, hostility and alexithymia levels in 70 methadone maintenance treatment patients. Results indicated that affective measures did not have the expected relationship with reported substance use. The authors advocate for the exploration of multiple factors, not merely emotional regulation, in the variability of substance use. JF - Journal of psychoactive drugs AU - Hall, Danny H AU - Queener, John E AD - University of California, San Francisco, USA. Danny.Hall2@va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 151 EP - 158 VL - 39 IS - 2 SN - 0279-1072, 0279-1072 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Anxiety -- psychology KW - Behavior, Addictive -- etiology KW - Humans KW - Anxiety -- epidemiology KW - Affective Symptoms -- psychology KW - Behavior, Addictive -- psychology KW - Affective Symptoms -- epidemiology KW - Hostility KW - Depression -- psychology KW - Adult KW - Depression -- epidemiology KW - Middle Aged KW - Male KW - Female KW - Self Medication -- psychology KW - Models, Psychological KW - Substance-Related Disorders -- etiology KW - Affect KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68171627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=Self-medication+hypothesis+of+substance+use%3A+testing+Khantzian%27s+updated+theory.&rft.au=Hall%2C+Danny+H%3BQueener%2C+John+E&rft.aulast=Hall&rft.aufirst=Danny&rft.date=2007-06-01&rft.volume=39&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characteristics of Residents and Providers in the Assisted Living Pilot Program AN - 61783133; 200936476 AB - Purpose: The number of residents in assisted living has rapidly increased, although these facilities still primarily serve people who can pay out of pocket. The U.S. Department of Veterans Affairs was authorized to provide this level of care for the first time in the Assisted Living Pilot Program (ALPP). We describe the residents and providers, comparing them across three facility types and other populations, to assess the characteristics and feasibility of this new approach. Design and Methods: We assessed ALPP residents and providers across seven Veterans Affairs Medical Centers. We obtained information from medical records, assessment tools, and a provider survey. Results: We report here on 743 residents placed from 2002 to 2004. The Department of Veterans Affairs contracted with 58 adult family homes, 56 assisted living facilities, and 46 residential care facilities. The average ALPP resident was a 70-year-old unmarried White man referred from an inpatient hospital and living in a private residence prior to placement. Adult family homes enrolled residents requiring greater levels of assistance with activities of daily living than other facility types. Assisted living facilities were less likely than adult family homes to admit residents with functional disabilities and less likely than either adult family homes or adult residential care facilities to admit residents with certain care needs. Implications: ALPP placed residents with a wide range of characteristics in community facilities that varied widely in size and services. This information can help determine the role of this type of care in and outside of the Department of Veterans Affairs. Adapted from the source document. JF - The Gerontologist AU - Hedrick, Susan AU - Guihan, Marylou AU - Chapko, Michael AU - Manheim, Larry AU - Sullivan, Jean AU - Thomas, Mark AU - Barry, Sarah AU - Zhou, Andrew AD - Health Services Research and Development, VA Puget Sound Health Care System, 1100 Olive Way, Suite 1400, Seattle, WA 98101. E-mail: susan.hedrick@med.va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 365 EP - 377 PB - Gerontological Society of America, Washington DC VL - 47 IS - 3 SN - 0016-9013, 0016-9013 KW - Assisted living facilities KW - Group homes KW - Long-term care KW - Department of Veterans Affairs KW - Veterans KW - Handicapped KW - Government Agencies KW - Residential Preferences KW - Residential Institutions KW - Nursing Homes KW - article KW - 2143: social problems and social welfare; social gerontology KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61783133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=Characteristics+of+Residents+and+Providers+in+the+Assisted+Living+Pilot+Program&rft.au=Hedrick%2C+Susan%3BGuihan%2C+Marylou%3BChapko%2C+Michael%3BManheim%2C+Larry%3BSullivan%2C+Jean%3BThomas%2C+Mark%3BBarry%2C+Sarah%3BZhou%2C+Andrew&rft.aulast=Hedrick&rft.aufirst=Susan&rft.date=2007-06-01&rft.volume=47&rft.issue=3&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Residential Institutions; Nursing Homes; Government Agencies; Handicapped; Veterans; Residential Preferences ER - TY - JOUR T1 - Posttraumatic Stress Disorder, Anger, and Partner Abuse Among Vietnam Combat Veterans AN - 61675464; 200804020 AB - The authors examined interrelationships among posttraumatic stress disorder (PTSD) symptomatology, anger, and partner abuse perpetration among a sample of 60 combat veterans. Compared with PTSD-negative participants, PTSD-positive participants reported higher state anger across time and neutral and trauma prime conditions and higher anger reactivity during the trauma prime condition. PTSD-positive participants also exhibited more anger reactivity during the trauma prime than during the neutral condition. The same pattern of results was not found for anxiety reactivity during trauma memory activation. PTSD symptoms were associated with physical assault and psychological aggression perpetration, and trait anger mediated these relationships. Findings indicate a heightened anger response among PTSD-positive veterans and suggest the salience of dispositional components of anger in abuse perpetration in this population. [Copyright 2007 The American Psychological Association.] JF - Journal of Family Psychology AU - Taft, Casey T AU - Street, Amy E AU - Marshall, Amy D AU - Dowdall, Deborah J AU - Riggs, David S AD - Veterans Affairs Boston Healthcare System (116B-20, 150 South Huntington Avenue, Boston, MA 02130 casey.taft@va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 270 EP - 277 PB - American Psychological Association, Washington DC VL - 21 IS - 2 SN - 0893-3200, 0893-3200 KW - posttraumatic stress disorder, anger, partner abuse, domestic violence, psychological aggression KW - Veterans KW - Partner Abuse KW - Posttraumatic Stress Disorder KW - Anger KW - Trauma KW - article KW - 2190: social problems and social welfare; victimology (rape, family violence, & child abuse) KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61675464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Psychology&rft.atitle=Posttraumatic+Stress+Disorder%2C+Anger%2C+and+Partner+Abuse+Among+Vietnam+Combat+Veterans&rft.au=Taft%2C+Casey+T%3BStreet%2C+Amy+E%3BMarshall%2C+Amy+D%3BDowdall%2C+Deborah+J%3BRiggs%2C+David+S&rft.aulast=Taft&rft.aufirst=Casey&rft.date=2007-06-01&rft.volume=21&rft.issue=2&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Psychology&rft.issn=08933200&rft_id=info:doi/10.1037%2F0893-3200.21.2.270 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-28 N1 - CODEN - JFPSEV N1 - SubjectsTermNotLitGenreText - Anger; Trauma; Partner Abuse; Posttraumatic Stress Disorder; Veterans DO - http://dx.doi.org/10.1037/0893-3200.21.2.270 ER - TY - JOUR T1 - Does Altering the Writing Instructions Influence Outcome Associated With Written Disclosure? AN - 57299757; 200916961 AB - This study examined the effect of changing the instructional set for written disclosure on psychological and physical health reports among traumatized college students with current posttraumatic stress symptoms. Eighty-two participants were randomly assigned to one of three writing conditions that focused on emotional expression (EE), insight and cognitive assimilation, or to a control condition. Participants assigned to the EE condition reported significant improvements in psychological and physical health 1 month following the writing sessions relative to the other two conditions. The EE participants also reported and displayed significantly greater initial psychophysiological reactivity and subsequent habituation compared with the other two conditions. These findings suggest the importance of emphasizing emotional expression during written disclosure and underscore the importance of examining how modifying the written disclosure protocol can affect outcome. [Copyright Association for Behavioral and Cognitive Therapies. Published by Elsevier Ltd.] JF - Behavior Therapy AU - Sloan, Denise M AU - Marx, Brian P AU - Epstein, Eva M AU - Lexington, Jennifer M AD - Temple University denise.sloan@va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 155 EP - 168 PB - Elsevier Ltd, The Netherlands VL - 38 IS - 2 SN - 0005-7894, 0005-7894 KW - Symptoms KW - Psychophysiological aspects KW - Outcomes KW - Health status KW - Disclosure KW - Habituation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57299757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Therapy&rft.atitle=Does+Altering+the+Writing+Instructions+Influence+Outcome+Associated+With+Written+Disclosure%3F&rft.au=Sloan%2C+Denise+M%3BMarx%2C+Brian+P%3BEpstein%2C+Eva+M%3BLexington%2C+Jennifer+M&rft.aulast=Sloan&rft.aufirst=Denise&rft.date=2007-06-01&rft.volume=38&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Behavior+Therapy&rft.issn=00057894&rft_id=info:doi/10.1016%2Fj.beth.2006.06.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Disclosure; Health status; Outcomes; Habituation; Psychophysiological aspects; Symptoms DO - http://dx.doi.org/10.1016/j.beth.2006.06.005 ER - TY - JOUR T1 - Integrating hepatitis prevention services into a substance use disorder clinic AN - 57222551; 200717056 AB - The Healthy Liver Program, established at the Minneapolis Veterans Affairs Medical Center Substance Use Disorder Clinic, provides screening for exposure to hepatitis infections, a group education class, and an individual nursing appointment to review screening results, give vaccinations for hepatitis A and hepatitis B, and make referrals to the hepatitis clinic as appropriate. A patient chart audit was completed 11 months after the establishment of the Healthy Liver Program. The attendance rate for the educational group and individual feedback sessions was 66.9%, with 94.1% of attendees accepting recommended hepatitis A and/or hepatitis B vaccinations. All patients with chronic hepatitis C who attended the Healthy Liver Program received a referral for evaluation in the hepatitis clinic, as compared with only 50% of patients with chronic hepatitis C who were identified before the establishment of the program. The importance of providing comprehensive educational sessions and recommendations for how patients with substance use disorders can access hepatitis screening, vaccination, and treatment resources are stressed. [Copyright 2007 Elsevier Inc.] JF - Journal of Substance Abuse Treatment AU - Hagedorn, Hildi AU - Dieperink, Eric AU - Dingmann, Debra AU - Durfee, Janet AU - Ho, Samuel B AU - Isenhart, Carl AU - Rettmann, Nancy AU - Willenbring, Mark AD - Minneapolis Veterans Affairs Medical Center, MN hildi.hagedorn@va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 391 EP - 398 PB - Elsevier, New York NY VL - 32 IS - 4 SN - 0740-5472, 0740-5472 KW - Substance abuse treatment programs KW - Hepatitis C infections KW - Hepatitis services KW - Implementation KW - Vaccinations KW - Hepatitis KW - Substance abuse disorders KW - Preventive health care KW - Community health centres KW - Immunization KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57222551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Integrating+hepatitis+prevention+services+into+a+substance+use+disorder+clinic&rft.au=Hagedorn%2C+Hildi%3BDieperink%2C+Eric%3BDingmann%2C+Debra%3BDurfee%2C+Janet%3BHo%2C+Samuel+B%3BIsenhart%2C+Carl%3BRettmann%2C+Nancy%3BWillenbring%2C+Mark&rft.aulast=Hagedorn&rft.aufirst=Hildi&rft.date=2007-06-01&rft.volume=32&rft.issue=4&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/10.1016%2Fj.jsat.2006.10.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-09-28 N1 - Last updated - 2016-09-27 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Preventive health care; Hepatitis; Substance abuse disorders; Community health centres; Immunization DO - http://dx.doi.org/10.1016/j.jsat.2006.10.004 ER - TY - JOUR T1 - The Utility of the NEO-PI-R Validity Scales to Detect Response Distortion: A Comparison With the MMPI-2 AN - 57075664; 200721091 AB - In this psychometric study, we compared the recently developed Validity Scales from the Revised NEO Personality Inventory (NEO PI-R, Costa & McCrae, 1992b) with the MMPI-2 (Butcher, Dahstrom, Graham, Tellegen, & Kaemmer, 1989) Validity Scales. We collected data from clients (n = 74) who completed comprehensive psychological evaluations at a university-based outpatient mental health clinic. Correlations between the Validity Scales of the NEO-PI-R and MMPI-2 were significant and in the expected directions. The relationships provide support for convergent and discriminant validity of the NEO-PI--R Validity Scales. The percent agreement of invalid responding on the two measures was high, although the diagnostic agreement was modest (K = .22-.33). Finally, clients who responded in an invalid manner on the NEO-PI-R Validity Scales produced significantly different clinical profiles on the NEO-PI-R and MMPI-2 than clients with valid protocols. These results provide additional support for the clinical utility of the NEO-PI-R Validity Scales as indicators of response bias. Adapted from the source document. JF - Journal of Personality Assessment AU - Morasco, Benjamin J AU - Gfeller, Jeffrey D AU - Elder, Katherine A AD - Portland VA Medical Center, 3710 SW US Veterans Hospital Road (P3MHDC), Portland, OR 97239 benjamin.morasco@va.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 276 EP - 283 PB - Lawrence Erlbaum Associates, Mahwah NJ VL - 88 IS - 3 SN - 0022-3891, 0022-3891 KW - Utility analysis KW - Scales KW - Validity KW - Psychometric properties KW - Personality tests KW - Response bias KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57075664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+Assessment&rft.atitle=The+Utility+of+the+NEO-PI-R+Validity+Scales+to+Detect+Response+Distortion%3A+A+Comparison+With+the+MMPI-2&rft.au=Morasco%2C+Benjamin+J%3BGfeller%2C+Jeffrey+D%3BElder%2C+Katherine+A&rft.aulast=Morasco&rft.aufirst=Benjamin&rft.date=2007-06-01&rft.volume=88&rft.issue=3&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+Assessment&rft.issn=00223891&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-12-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JNPABU N1 - SubjectsTermNotLitGenreText - Personality tests; Utility analysis; Psychometric properties; Validity; Scales; Response bias ER - TY - JOUR T1 - Who refuses enrollment in cardiac clinical trials? AN - 21341186; 10898584 AB - Objective To evaluate the factors associated with refusal to participate in acute cardiac clinical trials. Background Cardiac clinical trials in the acute setting pose a set of unique challenges to enrollment, such as the ability to obtain meaningful informed consent. In addition, it is unclear whether enrollment is associated with the sociodemographic characteristics (such as age, race and gender) of those being recruited. While policies have been instituted to enhance the representation of women and minorities in research, limited data exist on current enrollment patterns and reasons for refusal to participate in cardiac clinical trials. Methods 184 patients approached to participate in one of 25 cardiac clinical trials at Duke University Medical Center from 11/01 to 05/04 were surveyed regarding reasons for or against participation in clinical trials to identify predictors of non-enrollment. Results The mean age of the respondents was 61.6 years (SD 12.2), with 36% female and 32% non-white patients. There were no differences in refusal rates by age, gender or ethnicity. Higher acuity trials had higher refusal rates OR 3.6 (1.68-7.75) as well as not reading the informed consent form OR 2.99 (1.37-6.54). The main reasons people refused enrollment were due to inconvenience and not wanting to be experimented upon. Limitations This study was cross-sectional and conducted at a single institution that conducts a high-volume of clinical research. In addition, a majority of the patients in the procedure/device studies were enrolled in one relatively low-risk cardiac catheterization laboratory trial with a low refusal rate. These attributes may limit the generalizability of the findings reported here. Conclusion Older persons, women and minorities are equally likely to agree to enroll in cardiac clinical trials as younger persons, men and non-minorities. Future efforts to increase the efficiency of recruitment should focus on improving convenience for participants in this acute setting and improving basic understanding of clinical trials. Clinical Trials 2007; 4: 258-263; http://ctj.sagepub.com References 1. Sugarman J. Is the emperor really wearing new clothes? Informed consent for acute coronary syndromes. Am Heart J 2000; 140: 2-3.2. Kucia AM, Horowitz JD. Is informed consent to clinical trials an 'upside selective' process in acute coronary syndromes? Am Heart J 1999; 140: 94-97.3. Williams BF, French JK, White HD, and the HERO-2 consent substudy investigators. Informed consent during the clinical emergency of acute myocardial infarction (HERO-2 consent substudy): a prospective observational study. Lancet 2003; 361(9361): 918-22.4. Kahn JP, Mastroianni AM, Sugarman J eds. Beyond consent: seeking justice in research. New York: Oxford University Press, 1998.5. National Institutes of Health. NIH guidelines on the inclusion of women and minorities as subjects in clinical research. Fed Regist 1994; 59: 14508.6. Food and Drug Administration (FDA) Modernization Act of 1997 (FDAMA or the Act), Pub. L.No.105-115, 21 November, 1997.7. Lee PY, Alexander KP, Hammill BG, Pasquali SK, Peterson ED. Representation of elderly persons and women in published randomized trials of acute coronary syndromes. JAMA 2001; 286(6): 708-13.8. East MA, Peterson ED. Understanding racial differences in cardiovascular care and outcomes: issues for the new millennium. Am Heart J 2000; 139(5): 764-6.9. Hack TF, Degner LF, Dyck DA. Relationship between preferences for decision control and illness information among women with breast cancer: a quantitative and qualitative analysis. Soc Sci Med 1994; 39: 279-289. 10. Peterson E, Lytle BL, Biswas MS, Coombs L. Willingness to participate in cardiac trials. Am J Geriatr Cardiol 2004 Jan-Feb; 13(1): 11-5.11. Wendler D, Kington R, Madans J, et al. Are racial and ethnic minorities less willing to participate in health research? PLoS Med 2006; 3: 201-210.12. King SB III, Barnhart HX, Kosinshi AS et al. Angioplasty or surgery for multivessel coronary artery disease: comparison of eligible registry and radonized patients in the EAST trial and influence of treatment selection on outcomes. Emorg Angioplasty versus Surgery Trial Investigators Am J Cardiol 1997; 79(11): 1453-9.13. Williams BF, French JK, White HD. Is our method of obtaining consent appropriate for randomised controlled trials in acute myocardial infarction? N Z Med J 1997; 110: 298-299.14. Ockene IS, Miner J, Shannon TA, et al. The consent process in the Thrombolytics in Myocardial infarction (TIMI-phase I) trial. Clin Res 1991; 39: 13-17.15. Agard A, Hermeren G, Herlitz J. Patient's experiences of intervention trials on the treatment of myocardial infarction: is it time to adjust the informed consent procedure to the patient's capacity? Heart 1986; 2001: 632-637. JF - Clinical Trials AU - Sen Biswas, Mimi AU - Newby, L Kristin AU - Bastian, Lori A AU - Peterson, Eric D AU - Sugarman, Jeremy AD - Department of Medicine, Duke University Medical Center (DUMC), Durham, NC, USA, The Center of Health Services Research in Primary Care, Durham Veterans' Affairs Medical Center (DVAMC), Durham, NC, USA, Duke Clinical Research Institute (DCRI), DUMC, Durham, NC, USA, Durham Veterans Administration Medical Center, Durham, NC, USA, biswa004@nc.duke.edu Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 258 EP - 263 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU VL - 4 IS - 3 SN - 1740-7745, 1740-7745 KW - Risk Abstracts KW - Qualitative analysis KW - Age KW - Occupational safety KW - clinical trials KW - surgery KW - Efficiency KW - guidelines KW - intervention KW - recruitment KW - medical instruments KW - Drugs KW - Ethnic groups KW - myocardial infarction KW - Cancer KW - USA, New York KW - Gender KW - FDA KW - Breast cancer KW - elderly KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21341186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Who+refuses+enrollment+in+cardiac+clinical+trials%3F&rft.au=Sen+Biswas%2C+Mimi%3BNewby%2C+L+Kristin%3BBastian%2C+Lori+A%3BPeterson%2C+Eric+D%3BSugarman%2C+Jeremy&rft.aulast=Sen+Biswas&rft.aufirst=Mimi&rft.date=2007-06-01&rft.volume=4&rft.issue=3&rft.spage=258&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/10.1177%2F1740774507079434 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA, New York; clinical trials; myocardial infarction; Age; Gender; surgery; Occupational safety; Drugs; guidelines; Efficiency; Ethnic groups; FDA; intervention; Cancer; medical instruments; Breast cancer; recruitment; elderly; Qualitative analysis DO - http://dx.doi.org/10.1177/1740774507079434 ER - TY - JOUR T1 - Pneumocystis jiroveci (carinii) Pneumonia After Infliximab Therapy: A Review of 84 Cases AN - 20799482; 7466035 AB - Anti-tumor necrosis factor- alpha therapy, infliximab, has become an established effective therapy for Crohn's disease and rheumatoid arthritis. However, infliximab has been associated with various opportunistic pathogens such as tuberculosis, histoplasmosis, listeriosis, aspergillosis, and Pneumocystis jiroveci (carinii) pneumonia. We reviewed the FDA Adverse Event Reporting System for cases of Pneumocystis associated with infliximab use from January 1998 through December 2003. The database revealed 84 cases of PCP following infliximab therapy. Concomitant immunosuppressive medications included methotrexate, prednisone, azathioprine, 6-mercaptopurine, and cyclosporine. Mean time between infliximab infusion and onset of symptoms of pneumonia, when reported, was 21 days ( plus or minus 18 days; n=40). Twenty-three of the 84 (27%) patients died. The use of infliximab is associated with PCP infection. Further, the mortality rate for Pneumocystis following the use of infliximab is significant. The potential for severe disease, mortality, and often subtle presentation of these infections warrant close follow-up and careful monitoring after therapy. JF - Digestive Diseases and Sciences AU - Kaur, Nirmal AU - Mahl, Thomas C AD - Department of Medicine, VA Upstate New York, State University of New York at Buffalo School of Medicine, Buffalo, New York, 14215, USA, Thomas.Mahl@med.va.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1481 EP - 1484 PB - Springer New York, LLC, 233 Spring St New York NY 10013-1578 USA VL - 52 IS - 6 SN - 0163-2116, 0163-2116 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Prednisone KW - Mycobacterium KW - Listeriosis KW - Histoplasmosis KW - Pneumocystis KW - Aspergillosis KW - Aspergillus KW - 6-Mercaptopurine KW - Infection KW - Immunosuppressive agents KW - Cyclosporins KW - Necrosis KW - Methotrexate KW - Tuberculosis KW - Crohn's disease KW - Mortality KW - Monoclonal antibodies KW - Pathogens KW - infliximab KW - Databases KW - Rheumatoid arthritis KW - Tumor necrosis factor- alpha KW - Pneumonia KW - azathioprine KW - J 02400:Human Diseases KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20799482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+Diseases+and+Sciences&rft.atitle=Pneumocystis+jiroveci+%28carinii%29+Pneumonia+After+Infliximab+Therapy%3A+A+Review+of+84+Cases&rft.au=Kaur%2C+Nirmal%3BMahl%2C+Thomas+C&rft.aulast=Kaur&rft.aufirst=Nirmal&rft.date=2007-06-01&rft.volume=52&rft.issue=6&rft.spage=1481&rft.isbn=&rft.btitle=&rft.title=Digestive+Diseases+and+Sciences&rft.issn=01632116&rft_id=info:doi/10.1007%2Fs10620-006-9250-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Prednisone; Crohn's disease; Monoclonal antibodies; Listeriosis; Histoplasmosis; Aspergillosis; Pathogens; 6-Mercaptopurine; Infection; Cyclosporins; Immunosuppressive agents; infliximab; Databases; Necrosis; Rheumatoid arthritis; Methotrexate; Tuberculosis; Tumor necrosis factor- alpha; Pneumonia; azathioprine; Mycobacterium; Pneumocystis; Aspergillus DO - http://dx.doi.org/10.1007/s10620-006-9250-x ER - TY - JOUR T1 - A Cluster of Hemodialysis-Related Bacteremia Linked to Artificial Fingernails AN - 20297173; 7521572 AB - We examined a cluster of 5 hemodialysis patients who contracted gram-negative bacteremia. A nurse who used an artificial fingernail to open a vial of heparin that was mixed to make a flush solution had a culture of an artificial fingernail specimen positive for Serratia marcescens. The typing of the S. marcescens strains isolated from the 5 patients and the nurse showed them to be identical. This finding provides strong support for policies prohibiting artificial nails for healthcare workers in all hemodialysis units. JF - Infection Control and Hospital Epidemiology AU - Gordin, F M AU - Schultz, ME AU - Huber, R AU - Zubairi, S AU - Stock, F AU - Kariyil, J AD - Infectious Diseases (151B), Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA, fred.gordin@va.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 743 EP - 744 VL - 28 IS - 6 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - Typing KW - Fingernail KW - Serratia marcescens KW - Bacteremia KW - Nails KW - Hemodialysis KW - Heparin KW - Medical personnel KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20297173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=A+Cluster+of+Hemodialysis-Related+Bacteremia+Linked+to+Artificial+Fingernails&rft.au=Gordin%2C+F+M%3BSchultz%2C+ME%3BHuber%2C+R%3BZubairi%2C+S%3BStock%2C+F%3BKariyil%2C+J&rft.aulast=Gordin&rft.aufirst=F&rft.date=2007-06-01&rft.volume=28&rft.issue=6&rft.spage=743&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Typing; Fingernail; Bacteremia; Nails; Heparin; Hemodialysis; Medical personnel; Hospitals; Serratia marcescens ER - TY - JOUR T1 - The neurobiological and neurocognitive consequences of chronic cigarette smoking in alcohol use disorders AN - 19711322; 7521067 AB - A vast body of research attests to the adverse effects of chronic smoking on cardiac, pulmonary, and vascular function as well as the increased risk for various forms of cancer. However, comparatively little is known about the effects of chronic smoking on human brain function. Although smoking rates have decreased in the developed world, they remain high in individuals with alcohol use disorders. Despite the high prevalence of comorbid chronic smoking in alcohol use disorders, very few studies have addressed the potential neurobiological or neurocognitive effects of chronic smoking in alcohol use disorders. Here, we briefly review the existing literature on the neurobiological and neurocognitive consequences of chronic cigarette smoking and summarize our neuroimaging and neurocognitive studies on the effects of comorbid chronic excessive alcohol consumption and cigarette smoking in treatment-seeking and treatment-naive populations. Our research suggests comorbid chronic cigarette smoking modulates magnetic resonance-detectable brain injury and neurocognition in alcohol use disorders and that neurobiological recovery in our abstinent alcoholics is adversely affected by chronic smoking. Consideration of the potential separate effects and interactions of chronic smoking and alcohol consumption may foster a better understanding of specific mechanisms and neurocognitive consequences of brain injury in alcoholism and of brain recovery during sustained abstinence from alcohol. The material presented also contributes to ongoing discussions about treatment strategies for comorbid alcoholism and cigarette smoking and will hopefully stimulate further research into the neurobiological and neurocognitive consequences of chronic smoking in alcoholism and other substance use disorders. JF - Alcohol and Alcoholism AU - Durazzo, T C AU - Gazdzinski, S AU - Meyerhoff, D J AD - San Francisco Veterans Administration Medical Center, Center for Imaging of Neurode-generative Disease (114M), 4150 Clement St., San Francisco, CA 94121, USA, timothy.durazzo@ucsf.edu Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 174 EP - 185 VL - 42 IS - 3 SN - 0735-0414, 0735-0414 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Heart KW - Neuroimaging KW - Brain injury KW - Drug abuse KW - Cancer KW - Alcoholics KW - Cognition KW - Reviews KW - Alcoholism KW - Cigarette smoking KW - Side effects KW - Vascular system KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19711322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+Alcoholism&rft.atitle=The+neurobiological+and+neurocognitive+consequences+of+chronic+cigarette+smoking+in+alcohol+use+disorders&rft.au=Durazzo%2C+T+C%3BGazdzinski%2C+S%3BMeyerhoff%2C+D+J&rft.aulast=Durazzo&rft.aufirst=T&rft.date=2007-06-01&rft.volume=42&rft.issue=3&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+Alcoholism&rft.issn=07350414&rft_id=info:doi/10.1093%2Falcalc%2Fagm020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Heart; Neuroimaging; Brain injury; Drug abuse; Cognition; Alcoholics; Cancer; Reviews; Cigarette smoking; Alcoholism; Side effects; Ethanol; Vascular system DO - http://dx.doi.org/10.1093/alcalc/agm020 ER - TY - JOUR T1 - Epidemiology and Outcomes of Community-Associated Methicillin-Resistant Staphylococcus aureus Infection AN - 19700555; 7463065 AB - Over a 2-year period (2003 to 2005) patients with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and community-acquired methicillin-susceptible Staphylococcus aureus (CA-MSSA) infections were prospectively identified. Patients infected with CA-MRSA (n = 102 patients) and CA-MSSA (n = 102 patients) had median ages of 46 and 53 years, respectively; the most common sites of infection in the two groups were skin/soft tissue (80 and 93%, respectively), respiratory tract (13 and 6%, respectively), and blood (4 and 1%, respectively). Fourteen percent of patients with CA-MRSA infections and 3% of patients with CA-MSSA infections had household contacts with similar infections (P < 0.01). Among the CA-MRSA isolates, the pulsed-field gel electrophoresis (PFGE) groups detected were USA300 (49%) and USA100 (13%), with 27 PFGE groups overall; 71% of the isolates were staphylococcal chromosome cassette mec (SCCmec) type IV, 29% were SCCmec type II, and 54% had the Panton-Valentine leucocidin (PVL) gene. Among the CA-MSSA isolates there were 33 PFGE groups, with isolates of the USA200 group comprising 11%, isolates of the USA600 group comprising 11%, isolates of the USA100 group comprising 10%, and isolates of the PVL type comprising 10%. Forty-six and 18% of the patients infected with CA-MRSA and CA-MSSA, respectively, were hospitalized (P < 0.001). Fifty percent of the patients received antibiotic therapy alone, 5% received surgery alone, 30% received antibiotics and surgery, 3% received other therapy, and 12% received no treatment. The median durations of antibiotic therapy were 12 and 10 days in the CA-MRSA- and CA-MSSA-infected patients, respectively; 48 and 56% of the patients in the two groups received adequate antimicrobial therapy, respectively (P < 0.001). The clinical success rates of the initial therapy in the two groups were 61 and 84%, respectively (P < 0.001); recurrences were more common in the CA-MRSA group (recurrences were detected in 18 and 6% of the patients in the two groups, respectively [P < 0.001]). CA-MRSA was an independent predictor of clinical failure in multivariate analysis (odds ratio, 3.4; 95% confidence interval, 1.7 to 6.9). In the community setting, the molecular characteristics of the S. aureus strains were heterogeneous. CA-MRSA infections were associated with a more adverse impact on outcome than CA-MSSA infections. JF - Journal of Clinical Microbiology AU - Davis, S L AU - Perri, M B AU - Donabedian, S M AU - Manierski, C AU - Singh, A AU - Vager, D AU - Haque, N Z AU - Speirs, K AU - Muder, R R AU - Robinson-Dunn, B AU - Hayden, M K AU - Zervos, MJ AD - Henry Ford Hospital, Detroit, Michigan. Eugene Applebaum College of Pharmacy and Health Sciences. School of Medicine, Wayne State University, Detroit, Michigan. William Beaumont Hospital, Royal Oak, Michigan. Pittsburgh Veterans Administration Medical Center, Pittsburgh, Pennsylvania. Chicago Rush University, Chicago, Illinois Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1705 EP - 1711 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 45 IS - 6 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Skin KW - Drug resistance KW - Antibiotics KW - Infection KW - Blood KW - Chromosomes KW - Epidemiology KW - Multivariate analysis KW - Surgery KW - Pulsed-field gel electrophoresis KW - Staphylococcus aureus KW - Soft tissues KW - Respiratory tract KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19700555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Epidemiology+and+Outcomes+of+Community-Associated+Methicillin-Resistant+Staphylococcus+aureus+Infection&rft.au=Davis%2C+S+L%3BPerri%2C+M+B%3BDonabedian%2C+S+M%3BManierski%2C+C%3BSingh%2C+A%3BVager%2C+D%3BHaque%2C+N+Z%3BSpeirs%2C+K%3BMuder%2C+R+R%3BRobinson-Dunn%2C+B%3BHayden%2C+M+K%3BZervos%2C+MJ&rft.aulast=Davis&rft.aufirst=S&rft.date=2007-06-01&rft.volume=45&rft.issue=6&rft.spage=1705&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Blood; Chromosomes; Skin; Epidemiology; Multivariate analysis; Drug resistance; Surgery; Pulsed-field gel electrophoresis; Antibiotics; Infection; Soft tissues; Respiratory tract; Staphylococcus aureus ER - TY - JOUR T1 - Exercise Effect on Weight and Body Fat in Men and Women AN - 19692542; 7464292 AB - OBJECTIVES: The effect of national exercise recommendations on adiposity is unknown and may differ by sex. We examined long-term effects of aerobic exercise on adiposity in women and men. RESEARCH METHODS AND PROCEDURES: This was a 12-month randomized, controlled clinical trial testing exercise effect on weight and body composition in men (N = 102) and women (N = 100). Sedentary/unfit persons, 40 to 75 years old, were recruited through physician practices and media. The intervention was facility- and home-based moderate-to-vigorous intensity aerobic activity, 60 min/d, 6 days/wk vs. controls (no intervention). RESULTS: Exercisers exercised a mean 370 min/wk (men) and 295 min/wk (women), and seven dropped the intervention. Exercisers lost weight (women, -1.4 vs. +0.7 kg in controls, p = 0.008; men, -1.8 vs. -0.1 kg in controls, p = 0.03), BMI (women, -0.6 vs. +0.3 kg/m super(2) in controls, p = 0.006; men, -0.5 kg/m super(2) vs. no change in controls, p = 0.03), waist circumference (women, -1.4 vs. +2.2 cm in controls, p < 0.001; men, -3.3 vs. -0.4 cm in controls, p = 0.003), and total fat mass (women, -1.9 vs. +0.2 kg in controls, p = 0.001; men, -3.0 vs. +0.2 kg in controls, p < 0.001). Exercisers with greater increases in pedometer-measured steps per day had greater decreases in weight, BMI, body fat, and intra-abdominal fat (all p trend < 0.05 in both men and women). Similar trends were observed for increased minutes per day of exercise and for increases in maximal oxygen consumption. DISCUSSION: These data support the U.S. Department of Agriculture and Institute of Medicine guidelines of 60 min/d of moderate-to-vigorous physical activity. JF - Obesity Research AU - McTiernan, Anne AU - Sorensen, Bess AU - Irwin, Melinda L AU - Morgan, Angela AU - Yasui, Yutaka AU - Rudolph, Rebecca E AU - Surawicz, Christina AU - Lampe, Johanna W AU - Lampe, Paul D AU - Ayub, Kamran AU - Potter, John D AD - The Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, Washington. Epidemiology, Medicine, and. Pathobiology, Seattle, Washington. Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, Connecticut. Department of Public Health Sciences, University of Alberta, Edmonton, Alberta, Canada. Veterans Administration Puget Sound Health Care System, Health Services Research and Development Program, Seattle, Washington. Virginia Mason Medical Center, Seattle, Washington Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1496 EP - 1512 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 15 IS - 6 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Oxygen consumption KW - Obesity KW - Aerobics KW - Men KW - Women KW - Waist KW - Weight KW - Exercise (intensity) KW - Medicine KW - Physicians KW - Body composition KW - Trends KW - Sex KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19692542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Exercise+Effect+on+Weight+and+Body+Fat+in+Men+and+Women&rft.au=McTiernan%2C+Anne%3BSorensen%2C+Bess%3BIrwin%2C+Melinda+L%3BMorgan%2C+Angela%3BYasui%2C+Yutaka%3BRudolph%2C+Rebecca+E%3BSurawicz%2C+Christina%3BLampe%2C+Johanna+W%3BLampe%2C+Paul+D%3BAyub%2C+Kamran%3BPotter%2C+John+D&rft.aulast=McTiernan&rft.aufirst=Anne&rft.date=2007-06-01&rft.volume=15&rft.issue=6&rft.spage=1496&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Oxygen consumption; Obesity; Aerobics; Men; Women; Weight; Waist; Exercise (intensity); Physicians; Medicine; Trends; Body composition; Sex ER - TY - JOUR T1 - Extraintestinal Pathogenic Escherichia coli Survives within Neutrophils AN - 19661974; 7418045 AB - Extracellular pathogenic Escherichia coli (ExPEC) strains are common causes of a variety of clinical syndromes, including urinary tract infections, abdominal infections, nosocomial pneumonia, neonatal meningitis, and sepsis. ExPEC strains are extracellular bacterial pathogens; therefore, the innate immune response (e.g., professional phagocytes) plays a crucial role in the host defense against them. Studies using the model ExPEC strain CP9 demonstrated that it is relatively resistant to neutrophil-mediated bactericidal activity. Although this could be due to resistance to phagocytosis, the ability of CP9 to survive the intracellular killing mechanisms of neutrophils is another possibility. Using a variation of the intracellular invasion assay, we studied the survival of CP9 within peripheral blood-derived human neutrophils. Our results indicated that CP9 did survive within human neutrophils, but we were unable to demonstrate that intracellular replication occurred. This finding was not unique to CP9, since when a conservative assessment of survival was used, four of six additional ExPEC strains, but not an E. coli laboratory strain, were also capable of survival within neutrophils. Initial studies in which we began to decipher the mechanisms by which CP9 is able to successfully survive intracellular neutrophil-mediated bactericidal activity demonstrated that CP9 was at least partially susceptible to the neutrophil oxidative burst. Therefore, absolute resistance to the oxidative burst is not a mechanism by which ExPEC survives within neutrophils. In addition, electron microscopy studies showed that CP9 appeared to be present in phagosomes within neutrophils. Therefore, avoidance of phagosomal uptake or subsequent escape from the phagosome does not appear to be a mechanism that contributes to CP9's survival. These findings suggest that survival of ExPEC within neutrophils may be an important virulence mechanism. JF - Infection and Immunity AU - Nazareth, Helen AU - Genagon, Stacy A AU - Russo, Thomas A AD - Department of Medicine. Department of Microbiology. The Witebsky Center for Microbial Pathogenesis. Veterans Administration Western New York Healthcare System, University at Buffalo, Buffalo, New York Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 2776 EP - 2785 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 6 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Cell survival KW - Replication KW - Phagosomes KW - Leukocytes (neutrophilic) KW - Urinary tract KW - Pathogens KW - Infection KW - Intracellular killing KW - Meningitis KW - Virulence KW - Blood KW - Sepsis KW - Phagocytes KW - Escherichia coli KW - Immune response KW - Neonates KW - Phagocytosis KW - Bactericidal activity KW - Pneumonia KW - Electron microscopy KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19661974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Extraintestinal+Pathogenic+Escherichia+coli+Survives+within+Neutrophils&rft.au=Nazareth%2C+Helen%3BGenagon%2C+Stacy+A%3BRusso%2C+Thomas+A&rft.aulast=Nazareth&rft.aufirst=Helen&rft.date=2007-06-01&rft.volume=75&rft.issue=6&rft.spage=2776&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; Replication; Phagosomes; Leukocytes (neutrophilic); Pathogens; Urinary tract; Infection; Intracellular killing; Meningitis; Virulence; Blood; Sepsis; Phagocytes; Neonates; Immune response; Phagocytosis; Bactericidal activity; Electron microscopy; Pneumonia; Escherichia coli ER - TY - JOUR T1 - Activity of a cationic carotenoid derivative in a mouse model of protoporphyria. AN - 70503991; 17452109 AB - Prior work using cell culture has shown that certain synthetic carotenoid derivatives are more effective than natural carotenoids in preventing photosensitized cell killing. These carotenoid derivatives are either cationic or are weak bases. We have now found that of one of these derivatives, the Girard's reagent T derivative of beta-apo-8'-carotenal (GRT-carotenal) decreases acute photosensitivity in a mouse model of protoporphyria. When GRT-carotenal was added to the diet of SKH1 mice, both GRT-carotenal and its metabolites accumulated in the skin of the mice. Protoporphyria was induced in SKH1 mice by adding collidine to their diet. When the porphyric mice were exposed to 400 nm light (2.6+/-0.1 mW cm(-2)) for a period of 2h, the skin on the backs of these animals increased in thickness. Increased vascularity also developed in the skin of the mouse ears. Animals, that were fed a diet containing both collidine and GRT-carotenal and then exposed to light, had significantly smaller increases in skin thickness and less prominent increases in the vascular pattern on their ears. JF - Journal of photochemistry and photobiology. B, Biology AU - Kanofsky, Jeffrey R AU - Sima, Paul D AD - Medical and Neurology Service Line, Edward Hines Jr., Department of Veterans Affairs Hospital, P.O. Box 278, Hines, IL 60141, USA. jeff.kanofsky@med.va.gov Y1 - 2007/05/25/ PY - 2007 DA - 2007 May 25 SP - 124 EP - 129 VL - 87 IS - 2 SN - 1011-1344, 1011-1344 KW - Cations KW - 0 KW - GRP-carotenal KW - Pyridines KW - Carotenoids KW - 36-88-4 KW - gamma-collidine KW - 7IE4BK5J5V KW - Index Medicus KW - Light -- adverse effects KW - Animals KW - Treatment Outcome KW - Disease Models, Animal KW - Mice KW - Carotenoids -- therapeutic use KW - Photosensitivity Disorders -- chemically induced KW - Carotenoids -- chemical synthesis KW - Photosensitivity Disorders -- drug therapy KW - Carotenoids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70503991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+photochemistry+and+photobiology.+B%2C+Biology&rft.atitle=Activity+of+a+cationic+carotenoid+derivative+in+a+mouse+model+of+protoporphyria.&rft.au=Kanofsky%2C+Jeffrey+R%3BSima%2C+Paul+D&rft.aulast=Kanofsky&rft.aufirst=Jeffrey&rft.date=2007-05-25&rft.volume=87&rft.issue=2&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=Journal+of+photochemistry+and+photobiology.+B%2C+Biology&rft.issn=10111344&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-25 N1 - Date created - 2007-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Early inhibition of TNFalpha increases 6-hydroxydopamine-induced striatal degeneration. AN - 70405426; 17346684 AB - Evidence suggests that tumor necrosis factor alpha (TNF) is a leading cause of dopaminergic neuronal cell death. TNF also, however, has neuroprotective effects. Thus, TNF might have a dual role following injury: immediate release after injury is protective, whereas chronic increases are detrimental. In the present study, 6-hydroxydopamine was used to lesion the dorsal striatum in male Fisher 344 rats at 2 different time points. Group 1 received a daily injection of TNFalpha antisense oligodeoxyribonucleotide (ODN) or control on days 1 through 7 post-lesion. Group 2 received a daily injection of TNF antisense ODN or control on days 5 through 15 post-lesion. Rats were killed on the day following the last injection of TNF antisense ODN. Injection of TNF antisense ODN on days 1 through 7 increased the area of the tyrosine-hydroxylase-negative zone ipsilateral to the injection when compared to controls. In contrast, when inhibition of TNF was delayed, the area of tyrosine hydroxylase loss was significantly reduced. These findings suggest that TNF release is neuroprotective in the early stages of injury but becomes neurotoxic when chronically induced. JF - Brain research AU - Gemma, Carmelina AU - Catlow, Briony AU - Cole, Michael AU - Hudson, Charles AU - Samec, Amy AU - Shah, Nishan AU - Vila, Jennifer AU - Bachstetter, Adam AU - Bickford, Paula C AD - James A. Haley Veterans Administration Hospital, Tampa, FL, USA. Y1 - 2007/05/25/ PY - 2007 DA - 2007 May 25 SP - 240 EP - 247 VL - 1147 SN - 0006-8993, 0006-8993 KW - Oligodeoxyribonucleotides, Antisense KW - 0 KW - Tumor Necrosis Factor-alpha KW - Oxidopamine KW - 8HW4YBZ748 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Time Factors KW - Oligodeoxyribonucleotides, Antisense -- pharmacology KW - Immunohistochemistry KW - Male KW - Neostriatum -- metabolism KW - Nerve Degeneration -- metabolism KW - Tumor Necrosis Factor-alpha -- drug effects KW - Nerve Degeneration -- pathology KW - Neostriatum -- drug effects KW - Neostriatum -- pathology KW - Tumor Necrosis Factor-alpha -- metabolism KW - Parkinsonian Disorders -- pathology KW - Parkinsonian Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70405426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Early+inhibition+of+TNFalpha+increases+6-hydroxydopamine-induced+striatal+degeneration.&rft.au=Gemma%2C+Carmelina%3BCatlow%2C+Briony%3BCole%2C+Michael%3BHudson%2C+Charles%3BSamec%2C+Amy%3BShah%2C+Nishan%3BVila%2C+Jennifer%3BBachstetter%2C+Adam%3BBickford%2C+Paula+C&rft.aulast=Gemma&rft.aufirst=Carmelina&rft.date=2007-05-25&rft.volume=1147&rft.issue=&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-16 N1 - Date created - 2007-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Extracellular Heat Shock Protein-90Alpha: Linking Hypoxia to Skin Cell Motility and Wound Healing T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39401983; 4626290 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Li, W. AU - Li, Y. AU - Guan, S AU - Fan, J AU - Cheng, C AU - Bright, A AU - Chin, C AU - Chen, M AU - Woodley, D Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Hypoxia KW - Skin KW - Wound healing KW - Cell migration KW - Heat shock KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39401983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Extracellular+Heat+Shock+Protein-90Alpha%3A+Linking+Hypoxia+to+Skin+Cell+Motility+and+Wound+Healing&rft.au=Li%2C+W.%3BLi%2C+Y.%3BGuan%2C+S%3BFan%2C+J%3BCheng%2C+C%3BBright%2C+A%3BChin%2C+C%3BChen%2C+M%3BWoodley%2C+D&rft.aulast=Li&rft.aufirst=W.&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunohistochemical Profile of Keratocytes and Endothelium in Posterior Polymorphous Corneal Dystrophy T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40650137; 4573590 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Cockerham, G C AU - Ehrlich, J AU - Hidayat, A A Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Endothelium KW - Corneal dystrophy KW - Epithelia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40650137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Immunohistochemical+Profile+of+Keratocytes+and+Endothelium+in+Posterior+Polymorphous+Corneal+Dystrophy&rft.au=Cockerham%2C+G+C%3BEhrlich%2C+J%3BHidayat%2C+A+A&rft.aulast=Cockerham&rft.aufirst=G&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visual Performance of Patients with AMD using Wavefront-Guided Lenses T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40645350; 4573326 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Grant-Jordan, P AU - Szlyk, J P AU - Seiple, W AU - McMahon, T T AU - Kensick, J AU - Jethmalani, J AU - Dreher, A W Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Eye lens KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40645350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Visual+Performance+of+Patients+with+AMD+using+Wavefront-Guided+Lenses&rft.au=Grant-Jordan%2C+P%3BSzlyk%2C+J+P%3BSeiple%2C+W%3BMcMahon%2C+T+T%3BKensick%2C+J%3BJethmalani%2C+J%3BDreher%2C+A+W&rft.aulast=Grant-Jordan&rft.aufirst=P&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure Versus Function in Patients with Anterior Ischemic Optic Neuropathy (AION): A Test of a Linear Model T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40639875; 4570624 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Kardon, R H AU - Hood, D AU - Rouleau, J AU - Anderson, S AU - Wenick, A S AU - Deng, P AU - Grover, L AU - Ghadiali, Q AU - Behrens, M M AU - Odel, J Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Optics KW - Ischemia KW - Optic neuropathy KW - Structure-function relationships KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40639875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Structure+Versus+Function+in+Patients+with+Anterior+Ischemic+Optic+Neuropathy+%28AION%29%3A+A+Test+of+a+Linear+Model&rft.au=Kardon%2C+R+H%3BHood%2C+D%3BRouleau%2C+J%3BAnderson%2C+S%3BWenick%2C+A+S%3BDeng%2C+P%3BGrover%2C+L%3BGhadiali%2C+Q%3BBehrens%2C+M+M%3BOdel%2C+J&rft.aulast=Kardon&rft.aufirst=R&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Macular Functional and Structural Assessments of Patients with Macular Heterotopia due to Retinopathy of Prematurity T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40637378; 4571193 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Soong, G P AU - Shapiro, M AU - Seiple, W AU - Szlyk, J P Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Retinopathy KW - Structure-function relationships KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40637378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Macular+Functional+and+Structural+Assessments+of+Patients+with+Macular+Heterotopia+due+to+Retinopathy+of+Prematurity&rft.au=Soong%2C+G+P%3BShapiro%2C+M%3BSeiple%2C+W%3BSzlyk%2C+J+P&rft.aulast=Soong&rft.aufirst=G&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Total Deviation Probability Plots for Size V Perimetry: A Comparison with Size III T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40636999; 4569913 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Woodward, K R AU - Brito, C F AU - Doyle, C K AU - Kardon, R H AU - Johnson, C A AU - Wall, M Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Psychophysics KW - Visual field KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40636999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Total+Deviation+Probability+Plots+for+Size+V+Perimetry%3A+A+Comparison+with+Size+III&rft.au=Woodward%2C+K+R%3BBrito%2C+C+F%3BDoyle%2C+C+K%3BKardon%2C+R+H%3BJohnson%2C+C+A%3BWall%2C+M&rft.aulast=Woodward&rft.aufirst=K&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison of Catch Trial Methods Used in Conventional Perimetry in Glaucoma Patients T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40632861; 4569920 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Doyle, C K AU - Brito, C F AU - Woodward, K R AU - Johnson, C A AU - Wall, M Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Catches KW - Glaucoma KW - Clinical trials KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40632861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=A+Comparison+of+Catch+Trial+Methods+Used+in+Conventional+Perimetry+in+Glaucoma+Patients&rft.au=Doyle%2C+C+K%3BBrito%2C+C+F%3BWoodward%2C+K+R%3BJohnson%2C+C+A%3BWall%2C+M&rft.aulast=Doyle&rft.aufirst=C&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visual Acuity as a Component of a Digital Diabetic Eye Screening Protocol T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40629119; 4568753 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Kehler, L F AU - Barahimi, B AU - Rao, U S AU - Merin, L M AU - Recchia, C C AU - Chomsky, A S AU - Recchia, F M Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Eye KW - Acuity KW - Diabetes mellitus KW - Screening KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40629119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Visual+Acuity+as+a+Component+of+a+Digital+Diabetic+Eye+Screening+Protocol&rft.au=Kehler%2C+L+F%3BBarahimi%2C+B%3BRao%2C+U+S%3BMerin%2C+L+M%3BRecchia%2C+C+C%3BChomsky%2C+A+S%3BRecchia%2C+F+M&rft.aulast=Kehler&rft.aufirst=L&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Effects of Verbal Cue on Bolus Flow During Swallowing AN - 85657478; 200802264 AB - Purpose: To examine the effects of verbal cuing to initiate swallowing on bolus flow measures in healthy adults. Method: Videofluoroscopic examinations were completed in 12 healthy older adults (median age = 69 years) as they swallowed 5 ml of self-administered liquid barium in 2 conditions: verbally cued and noncued swallows. In the cued condition, participants held the liquid in their mouths until instructed to swallow. In the noncued condition, participants swallowed in their usual manner. Results: Verbal cue affected bolus position at onset of timing measures, thereby influencing duration. The bolus was positioned more posterior in the oral cavity at onset of oral transit for cued as compared with noncued swallows. The leading edge of the bolus at onset of the pharyngeal swallow was more superior in the pharynx for cued as compared with noncued swallows. Durations of the cued swallows were significantly shorter than for noncued swallows for all timing measures. Bolus direction scores were not significantly different between conditions. Conclusions: Findings suggest that swallowing is altered by the use of verbal cues to initiate swallowing in healthy adults. Determining whether shorter durations with implementation of verbal cues are evident in individuals with dysphagia and whether effects are beneficial or deleterious requires continued research. Adapted from the source document JF - American Journal of Speech-Language Pathology AU - Daniels, Stephanie K AU - Schroeder, Mae Fern AU - Degeorge, Pamela C AU - Corey, David M AU - Rosenbek, John C AD - Rehab Research (153), Michael E. DeBakey VA Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030. stephanie.daniels@va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 140 EP - 147 VL - 16 IS - 2 SN - 1058-0360, 1058-0360 KW - Articulatory Measurement Techniques (04730) KW - Oral Cavity (61200) KW - Verbal Learning (93750) KW - Adults (00600) KW - Speech Therapy (83200) KW - article KW - 6210: hearing and speech physiology; hearing and speech physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85657478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Speech-Language+Pathology&rft.atitle=Effects+of+Verbal+Cue+on+Bolus+Flow+During+Swallowing&rft.au=Daniels%2C+Stephanie+K%3BSchroeder%2C+Mae+Fern%3BDegeorge%2C+Pamela+C%3BCorey%2C+David+M%3BRosenbek%2C+John+C&rft.aulast=Daniels&rft.aufirst=Stephanie&rft.date=2007-05-01&rft.volume=16&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Speech-Language+Pathology&rft.issn=10580360&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2008-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJSPFZ N1 - SubjectsTermNotLitGenreText - Oral Cavity (61200); Adults (00600); Verbal Learning (93750); Speech Therapy (83200); Articulatory Measurement Techniques (04730) ER - TY - JOUR T1 - Symptom assessment tools for gastroesophageal reflux disease (GERD) treatment. AN - 85413283; pmid-17450022 AB - Relief of symptoms, both typical and atypical, is the mainstay of therapy for patients with gastroesophageal reflux disease (GERD); however, evaluation of GERD symptoms' response to treatment has been hampered by the lack of a questionnaire that meets all the criteria of an ideal evaluative GERD symptom assessment tool. These criteria are: sensitivity in GERD patients, covering all symptom dimensions (multidimensional construct), assessment of frequency and intensity of "typical" and "atypical" GERD symptoms, practical and economical, easy to understand, responsive over short time intervals, use as a patient self-assessment tool, amenable to daily use, psychometrically validated, and translation into many languages with cross-cultural adaptation. Thus far, 14 instruments have been developed to assess GERD symptoms and potentially can be used to evaluate treatment response during a therapeutic trial in GERD patients. However, comparison of the different evaluative tools is needed. JF - Journal of clinical gastroenterology AU - Fass, Ronnie AD - The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723, USA. Ronnie.Fass@med.VA.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 437 EP - 444 VL - 41 IS - 5 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - *Gastroesophageal Reflux: diagnosis KW - Gastroesophageal Reflux: prevention & control KW - Health Status Indicators KW - Humans KW - Psychometrics KW - Quality of Life KW - Questionnaires KW - Reproducibility of Results KW - Sensitivity and Specificity KW - *Severity of Illness Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85413283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Symptom+assessment+tools+for+gastroesophageal+reflux+disease+%28GERD%29+treatment.&rft.au=Fass%2C+Ronnie&rft.aulast=Fass&rft.aufirst=Ronnie&rft.date=2007-05-01&rft.volume=41&rft.issue=5&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - An fMRI study of the interaction of stress and cocaine cues on cocaine craving in cocaine-dependent men. AN - 70687732; 17612820 AB - Acute stress is associated with relapse in cocaine addiction, possibly through the activation of craving-related neural circuitry. Neural responses to cocaine cues and acute stress were investigated in an fMRI study. Ten male participants mentally re-enacted personalized scripts about cocaine use and a neutral experience both with and without a stressor present (anticipation of electrical shock). Interaction analysis between script type and stress condition revealed greater activation of the posterior cingulate cortex and of the parietal lobe during the cocaine script in the presence of the stressor. These data suggest that stress may precipitate relapse in cocaine addiction by activating brain areas that mediate reward processing and the attentional and mnemonic bias for drug use reminders. JF - The American journal on addictions AU - Duncan, Erica AU - Boshoven, William AU - Harenski, Keith AU - Fiallos, Ana AU - Tracy, Holly AU - Jovanovic, Tanja AU - Hu, Xiaoping AU - Drexler, Karen AU - Kilts, Clint AD - Atlanta VA Medical Center, Decatur, GA 30033, USA. erica.duncan@va.gov PY - 2007 SP - 174 EP - 182 VL - 16 IS - 3 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - Gyrus Cinguli -- physiopathology KW - Humans KW - Neural Pathways -- physiology KW - Adult KW - Thalamus -- physiopathology KW - Middle Aged KW - Behavior, Addictive -- physiopathology KW - Parietal Lobe -- physiopathology KW - Recurrence KW - Male KW - Cerebral Cortex -- physiopathology KW - Magnetic Resonance Imaging KW - Brain -- physiopathology KW - Stress, Psychological KW - Cocaine-Related Disorders -- psychology KW - Cues KW - Cocaine-Related Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70687732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=An+fMRI+study+of+the+interaction+of+stress+and+cocaine+cues+on+cocaine+craving+in+cocaine-dependent+men.&rft.au=Duncan%2C+Erica%3BBoshoven%2C+William%3BHarenski%2C+Keith%3BFiallos%2C+Ana%3BTracy%2C+Holly%3BJovanovic%2C+Tanja%3BHu%2C+Xiaoping%3BDrexler%2C+Karen%3BKilts%2C+Clint&rft.aulast=Duncan&rft.aufirst=Erica&rft.date=2007-05-01&rft.volume=16&rft.issue=3&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-30 N1 - Date created - 2007-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuropsychological exploration of alleged mold neurotoxicity. AN - 70558729; 17521866 AB - Cognitive and emotional correlates of toxic mold exposure and potential dose-response effects for both outcomes were investigated. Self-reported length of exposure, time since last exposure, and serum immunoglobulin (IgG) levels were assessed. Despite CNS complaints often seen with mold exposed individuals, overall results did not uncover concomitant cognitive deficits suggested in previous studies or a significant reduction in intellectual functioning. Fewer subjects were excluded as result of failing effort/motivation assessment than expected. Correlations of IgG and cognitive function are discussed. A dose-effect for self-reported length of exposure and cognitive outcome was not seen. The sample's overall Minnesota Multiphasic Personality Inventory II (MMPI-2) profile indicated elevations on scales 1, 2, 3, 7 and 8. MMPI-2 clinical scales 1 and 3 were significantly correlated with length of exposure. The MMPI-2 may be sensitive to increasing physical and emotional sequelae as length of exposure increases. A potential subgroup of cognitively impaired outliers within mold exposure litigants is explored. Limitations of self-reported and objective measurements for mold exposure and exploratory statistical methodology are discussed. JF - Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists AU - Reinhard, Matthew J AU - Satz, Paul AU - Scaglione, Cris A AU - D'Elia, Louis F AU - Rassovsky, Yuri AU - Arita, Anthony A AU - Hinkin, Charles H AU - Thrasher, Delaney AU - Ordog, Gary AD - University of California Los Angeles, Semel Institute of Neuroscience and Human Behavior, United States. matthew.reinhard@va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 533 EP - 543 VL - 22 IS - 4 SN - 0887-6177, 0887-6177 KW - Immunoglobulin G KW - 0 KW - Index Medicus KW - Immunoglobulin G -- blood KW - Humans KW - MMPI KW - Adult KW - Middle Aged KW - Neuropsychological Tests KW - Male KW - Female KW - Neurotoxicity Syndromes -- psychology KW - Affective Symptoms -- etiology KW - Cognition Disorders -- etiology KW - Affective Symptoms -- blood KW - Fungi KW - Neurotoxicity Syndromes -- blood KW - Neurotoxicity Syndromes -- microbiology KW - Environmental Exposure -- adverse effects KW - Cognition Disorders -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70558729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+clinical+neuropsychology+%3A+the+official+journal+of+the+National+Academy+of+Neuropsychologists&rft.atitle=Neuropsychological+exploration+of+alleged+mold+neurotoxicity.&rft.au=Reinhard%2C+Matthew+J%3BSatz%2C+Paul%3BScaglione%2C+Cris+A%3BD%27Elia%2C+Louis+F%3BRassovsky%2C+Yuri%3BArita%2C+Anthony+A%3BHinkin%2C+Charles+H%3BThrasher%2C+Delaney%3BOrdog%2C+Gary&rft.aulast=Reinhard&rft.aufirst=Matthew&rft.date=2007-05-01&rft.volume=22&rft.issue=4&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=Archives+of+clinical+neuropsychology+%3A+the+official+journal+of+the+National+Academy+of+Neuropsychologists&rft.issn=08876177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estimating the rate of accumulating drug resistance mutations in the HIV genome. AN - 70546522; 17532813 AB - HIV mutation accumulation has great implications for pharmacoeconomics and clinical care, yet scarcity of data has hindered its representation in decision analytic models. Our objective is to determine the accuracy with which mutation accumulation and other unmeasured parameters could be estimated during model calibration. We used a second-order Monte Carlo simulation of HIV natural history that had been calibrated by varying two unmeasured parameters (mutation accrual rate and probability of adherence) to minimize differences between estimated and observed clinical outcomes (time to treatment failure and survival). We compared these estimated values first with only those results that had been already published at the time of model calibration, and second including results that were published after model calibration. The value for mutation accrual rate assigned during calibration was 0.014 mutations per month for antiretroviral-naïve patients, at the lower bound of the results for nine heterogeneous studies published at the time of calibration (pooled 95% confidence interval [CI] 0.014-0.039 mutations per month). In contrast, this estimate accurately anticipated results from 11 larger and more homogeneous studies published after calibration (pooled 95% CI for antiretroviral-naïve patients, 0.012-0.015 mutations per month). The value for probability of adherence assigned during calibration (75%) was also within the range of published results (pooled 95% CI 62-76%). Estimates for unobserved parameters derived during model calibration were not only within the range of clinical observations, but anticipated with accuracy clinical results that were not yet available. It may be feasible to use models to estimate unobserved parameters. JF - Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research AU - Braithwaite, R Scott AU - Shechter, Steven AU - Chang, Chung-Chou H AU - Schaefer, Andrew AU - Roberts, Mark S AD - Yale University School of Medicine/Connecticut VA Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA. Ronald.braithwaite@med.va.gov PY - 2007 SP - 204 EP - 213 VL - 10 IS - 3 SN - 1098-3015, 1098-3015 KW - Index Medicus KW - Patient Compliance -- statistics & numerical data KW - Computer Simulation KW - Reproducibility of Results KW - Humans KW - Calibration KW - Monte Carlo Method KW - HIV -- drug effects KW - Antiretroviral Therapy, Highly Active -- adverse effects KW - Drug Resistance, Viral -- genetics KW - Mutation -- genetics KW - HIV -- genetics KW - Drug Resistance, Viral -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70546522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Value+in+health+%3A+the+journal+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research&rft.atitle=Estimating+the+rate+of+accumulating+drug+resistance+mutations+in+the+HIV+genome.&rft.au=Braithwaite%2C+R+Scott%3BShechter%2C+Steven%3BChang%2C+Chung-Chou+H%3BSchaefer%2C+Andrew%3BRoberts%2C+Mark+S&rft.aulast=Braithwaite&rft.aufirst=R&rft.date=2007-05-01&rft.volume=10&rft.issue=3&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Value+in+health+%3A+the+journal+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research&rft.issn=10983015&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-24 N1 - Date created - 2007-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dysphagia: a rare form of dyskinesia? AN - 70543136; 17522565 JF - Journal of psychiatric practice AU - Nieves, J Edwin AU - Stack, Kathleen M AU - Harrison, Megan E AU - Gorman, Jack M AD - Hampton Veterans Administration Medical Center, Hampton, VA, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 199 EP - 201 VL - 13 IS - 3 SN - 1527-4160, 1527-4160 KW - Anticonvulsants KW - 0 KW - Antipsychotic Agents KW - Clonazepam KW - 5PE9FDE8GB KW - Index Medicus KW - Clonazepam -- adverse effects KW - Substance Withdrawal Syndrome -- diagnosis KW - Humans KW - Neurologic Examination -- drug effects KW - Anticonvulsants -- adverse effects KW - Substance Withdrawal Syndrome -- drug therapy KW - Middle Aged KW - Clonazepam -- therapeutic use KW - Anticonvulsants -- therapeutic use KW - Male KW - Dyskinesia, Drug-Induced -- drug therapy KW - Antipsychotic Agents -- therapeutic use KW - Dyskinesia, Drug-Induced -- diagnosis KW - Deglutition Disorders -- drug therapy KW - Deglutition Disorders -- chemically induced KW - Schizophrenia -- drug therapy KW - Deglutition Disorders -- diagnosis KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70543136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychiatric+practice&rft.atitle=Dysphagia%3A+a+rare+form+of+dyskinesia%3F&rft.au=Nieves%2C+J+Edwin%3BStack%2C+Kathleen+M%3BHarrison%2C+Megan+E%3BGorman%2C+Jack+M&rft.aulast=Nieves&rft.aufirst=J&rft.date=2007-05-01&rft.volume=13&rft.issue=3&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychiatric+practice&rft.issn=15274160&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-17 N1 - Date created - 2007-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nocebo effects with antidepressant clinical drug trial placebos. AN - 70478925; 17484949 AB - We describe an individual who experienced unusual negative effects while taking a placebo during a clinical drug trial. A 26-year-old male took 29 inert capsules, believing he was overdosing on an antidepressant. Subsequently, he experienced hypotension requiring intravenous fluids to maintain an adequate blood pressure until the true nature of the capsules was revealed. The adverse symptoms then rapidly abated. The nocebo effect (undesirable symptoms following administration of an inert substance that the patient believes to be an active drug) may have significant negative impacts on certain patients. Further research is warranted to better understand this phenomenon. JF - General hospital psychiatry AU - Reeves, Roy R AU - Ladner, Mark E AU - Hart, Roy H AU - Burke, Randy S AD - GV (Sonny) VA Medical Center, Mental Health Service, Jackson, MS 39216, USA. roy.reeves@med.va.gov PY - 2007 SP - 275 EP - 277 VL - 29 IS - 3 SN - 0163-8343, 0163-8343 KW - Antidepressive Agents KW - 0 KW - Placebos KW - Index Medicus KW - Personality Tests KW - Humans KW - Adult KW - Treatment Outcome KW - Clinical Trials as Topic KW - Antidepressive Agents -- therapeutic use KW - Antidepressive Agents -- adverse effects KW - Male KW - Placebos -- adverse effects KW - Placebo Effect KW - Depression -- etiology KW - Depression -- psychology KW - Hypotension -- psychology KW - Depression -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70478925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=General+hospital+psychiatry&rft.atitle=Nocebo+effects+with+antidepressant+clinical+drug+trial+placebos.&rft.au=Reeves%2C+Roy+R%3BLadner%2C+Mark+E%3BHart%2C+Roy+H%3BBurke%2C+Randy+S&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2007-05-01&rft.volume=29&rft.issue=3&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=General+hospital+psychiatry&rft.issn=01638343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-08 N1 - Date created - 2007-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - General characteristics of treatable, reversible, and untreatable dementias. AN - 70465983; 17483664 AB - The modification of cognitive function with age has been the focus of numerous studies. Most of the research has suggested that these changes, at least in the majority of individuals, occur only at a very advanced stage; however, those conditions that are treatable and potentially reversible are acute in onset and often associated with acute confusional states. Therefore, physicians should be aware of the possibility of reversible causes of cognitive change in their elderly patients, including certain medications responsible for memory loss and other organ system diseases. In addition, the authors stress that not all memory loss in geriatric patients is due to Alzheimer's disease and that when history and physical examination provide evidence of hypertension and magnetic resonance imaging provides evidence of leukoaraiosis, a diagnosis of vascular dementia should be considered. JF - The American journal of geriatric cardiology AU - Lowenthal, David T AU - Paran, Esther AU - Burgos, Luis AU - Williams, Leonard S AD - University of Florida College of Medicine, Gainesville, FL 32608, USA. david.lowenthal@va.gov PY - 2007 SP - 136 EP - 142 VL - 16 IS - 3 SN - 1076-7460, 1076-7460 KW - Antihypertensive Agents KW - 0 KW - Index Medicus KW - Memory Disorders -- chemically induced KW - Diagnosis, Differential KW - Memory Disorders -- diagnosis KW - Humans KW - Antihypertensive Agents -- adverse effects KW - Aged KW - Dementia, Vascular -- diagnosis KW - Confusion -- chemically induced KW - Cognition Disorders -- complications KW - Dementia, Vascular -- complications KW - Vascular Diseases -- complications KW - Dementia -- complications KW - Dementia -- diagnosis KW - Geriatric Assessment KW - Vascular Diseases -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70465983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+geriatric+cardiology&rft.atitle=General+characteristics+of+treatable%2C+reversible%2C+and+untreatable+dementias.&rft.au=Lowenthal%2C+David+T%3BParan%2C+Esther%3BBurgos%2C+Luis%3BWilliams%2C+Leonard+S&rft.aulast=Lowenthal&rft.aufirst=David&rft.date=2007-05-01&rft.volume=16&rft.issue=3&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+geriatric+cardiology&rft.issn=10767460&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-27 N1 - Date created - 2007-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Implications of the changing face of Clostridium difficile disease for health care practitioners. AN - 70460876; 17482995 AB - Recent reported outbreaks of Clostridium difficile-associated disease in Canada have changed the profile of C difficile infections. Historically, C difficile disease was thought of mainly as a nosocomial disease associated with broad-spectrum antibiotics, and the disease was usually not life threatening. The emergence of an epidemic strain, BI/NAP1/027, which produces a binary toxin in addition to the 2 classic C difficile toxins A and B and is resistant to some fluoroquinolones, was associated with large numbers of cases with high rates of mortality. Recently, C difficile has been reported more frequently in nonhospital-based settings, such as community-acquired cases. The C difficile disease is also being reported in populations once considered of low risk (children and young healthy women). In addition, poor response to metronidazole treatment is increasing. Faced with an increasing incidence of C difficile infections and the changing profile of patients who become infected, this paper will reexamine the current concepts on the epidemiology and treatment of C difficile-associated disease, present new hypotheses for risk factors, examine the role of spores in the transmission of C difficile, and provide recommendations that may enhance infection control practices. JF - American journal of infection control AU - McFarland, Lynne V AU - Beneda, Henry W AU - Clarridge, Jill E AU - Raugi, Gregory J AD - From the Department of Health Services Research and Development, Veterans Administration Puget Sound Health Care System, Seattle, WA 98101, USA. Lynne.McFarland@va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 237 EP - 253 VL - 35 IS - 4 SN - 0196-6553, 0196-6553 KW - Antacids KW - 0 KW - Anti-Infective Agents KW - Bacterial Toxins KW - Fluoroquinolones KW - Proton Pump Inhibitors KW - Index Medicus KW - Virulence KW - United States KW - Fluoroquinolones -- adverse effects KW - Anti-Infective Agents -- adverse effects KW - Canada KW - Infection Control -- methods KW - Humans KW - Bacterial Toxins -- classification KW - Antacids -- adverse effects KW - Enterocolitis, Pseudomembranous -- epidemiology KW - Clostridium difficile -- pathogenicity KW - Cross Infection -- microbiology KW - Enterocolitis, Pseudomembranous -- microbiology KW - Enterocolitis, Pseudomembranous -- drug therapy KW - Cross Infection -- prevention & control KW - Clostridium difficile -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70460876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+infection+control&rft.atitle=Implications+of+the+changing+face+of+Clostridium+difficile+disease+for+health+care+practitioners.&rft.au=McFarland%2C+Lynne+V%3BBeneda%2C+Henry+W%3BClarridge%2C+Jill+E%3BRaugi%2C+Gregory+J&rft.aulast=McFarland&rft.aufirst=Lynne&rft.date=2007-05-01&rft.volume=35&rft.issue=4&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=American+journal+of+infection+control&rft.issn=01966553&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-26 N1 - Date created - 2007-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effect of acetaminophen on the international normalized ratio in patients stabilized on warfarin therapy. AN - 70434345; 17461702 AB - To determine whether an interaction exists between acetaminophen and warfarin that alters the international normalized ratio (INR). Prospective, randomized, double-blind, placebo-controlled trial. Anticoagulation clinic at a Veterans Affairs Medical Center. Thirty-six adult patients receiving warfarin with stable INRs, defined as two consecutive INRs at least 3 weeks apart that were within the therapeutic range. Patients were randomly assigned to receive acetaminophen 1 g twice/day along with matching placebo twice/day (12 patients), acetaminophen 1 g 4 times/day (12 patients), or matching placebo 4 times/day (12 patients) for 4 weeks. The primary end point was the difference in mean INR between groups at weekly intervals. Secondary end points were the percentages of patients in each group with supratherapeutic (INR > or = 0.3 above the upper limit of their therapeutic range) or subtherapeutic (INR > or = 0.2 or 0.3 below the lower limit of their respective therapeutic range of 2.0-3.0 or 2.5-3.5) INRs, and the difference in mean serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels between groups at biweekly intervals. Slow enrollment and a preliminary observation that 15 patients experienced an elevated INR prompted early termination of the study. At week 2, the group receiving acetaminophen 2 g/day had a significantly higher mean INR versus the placebo group (p=0.01). At weeks 1, 2, and 3, the acetaminophen 4-g/day group had significantly higher mean INRs compared with those in the placebo group (p=0.04, p=0.01, p=0.01, respectively). In addition, 13 (54%) of 24 patients in the acetaminophen groups combined exceeded the upper limit of their therapeutic range by 0.3 or greater compared with only 2 (17%) of 12 patients in the placebo group. No statistically significant differences in serum ALT or AST levels between either acetaminophen group versus the placebo group were found at week 4; however, there was a statistically significant increase in mean ALT level at week 2 in the acetaminophen 4-g/day group versus the placebo group. These findings support the existence of a clinically significant interaction between warfarin and daily use of acetaminophen 2-4 g, necessitating close monitoring of patients who receive this drug combination. Whether this interaction occurs when acetaminophen is taken in lower doses or is used sporadically requires further study. JF - Pharmacotherapy AU - Parra, David AU - Beckey, Nick P AU - Stevens, Gary R AD - Section of Clinical Pharmacy, Patient Support Service, Department of Veterans Affairs Medical Center, West Palm Beach, Florida 33410-6400, USA. David.Parra@med.va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 675 EP - 683 VL - 27 IS - 5 SN - 0277-0008, 0277-0008 KW - Analgesics, Non-Narcotic KW - 0 KW - Anticoagulants KW - Acetaminophen KW - 362O9ITL9D KW - Warfarin KW - 5Q7ZVV76EI KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Aspartate Aminotransferases -- blood KW - Drug Interactions KW - Alanine Transaminase -- blood KW - Prospective Studies KW - Double-Blind Method KW - Humans KW - Drug Monitoring KW - Aspartate Aminotransferases -- drug effects KW - Aged KW - Middle Aged KW - Alanine Transaminase -- drug effects KW - Male KW - Female KW - Acetaminophen -- administration & dosage KW - Analgesics, Non-Narcotic -- pharmacokinetics KW - Acetaminophen -- pharmacokinetics KW - International Normalized Ratio KW - Anticoagulants -- pharmacology KW - Analgesics, Non-Narcotic -- administration & dosage KW - Warfarin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70434345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=The+effect+of+acetaminophen+on+the+international+normalized+ratio+in+patients+stabilized+on+warfarin+therapy.&rft.au=Parra%2C+David%3BBeckey%2C+Nick+P%3BStevens%2C+Gary+R&rft.aulast=Parra&rft.aufirst=David&rft.date=2007-05-01&rft.volume=27&rft.issue=5&rft.spage=675&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-26 N1 - Date created - 2007-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development and reliability testing of the clinical pharmacist recommendation taxonomy. AN - 70430566; 17461698 AB - To evaluate the reliability of a newly developed taxonomy--the Clinical Pharmacist Recommendation (CPR) taxonomy--to classify clinical pharmacy interventions. The CPR taxonomy was developed and refined in three phases. In each phase, reviewers independently reviewed recommendations made by a clinical pharmacist-physician team and categorized them into mutually exclusive categories: priority, problem, and response. Interrater reliability was assessed for all categories during each development phase. Primary care clinics of a Veterans Affairs Medical Center. Fifty-three patients enrolled in the Veterans Affairs Enhanced Pharmacy Outpatient Clinic (EPOC) trial. Interrater reliability was assessed using the kappa statistic. A total of 423 recommendations were evaluated during the three testing phases. In the final testing phase, agreement was moderate for pharmacotherapy problem subcategories (kappa = 0.57), substantial for pharmacotherapy problem primary categories (kappa = 0.64), and almost perfect for response categories (kappa = 0.85). Taxonomy completion time/patient averaged 4.6 minutes (range 1-11 min). The CPR taxonomy provides a reliable method to systematically evaluate clinical pharmacy recommendations based on the therapeutic problem identified and specific action recommended to resolve the problem. JF - Pharmacotherapy AU - Hoth, Angela B AU - Carter, Barry L AU - Ness, Jose AU - Bhattacharyya, Anjan AU - Shorr, Ronald I AU - Rosenthal, Gary E AU - Kaboli, Peter J AD - Center for Research in the Implementation of Innovative Strategies in Practice, Veterans Affairs Iowa City Health Care System, Iowa City, Iowa 52246, USA. Angela.Hoth@med.va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 639 EP - 646 VL - 27 IS - 5 SN - 0277-0008, 0277-0008 KW - Index Medicus KW - United States KW - Drug Therapy -- classification KW - Reproducibility of Results KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Aged KW - Primary Health Care KW - Male KW - Female KW - Hospitals, Veterans KW - Pharmacy Service, Hospital -- classification KW - Pharmacy Service, Hospital -- organization & administration KW - Pharmacy Service, Hospital -- methods KW - Professional Role KW - Pharmacy Service, Hospital -- standards KW - Quality Assurance, Health Care -- methods KW - Pharmacists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70430566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Development+and+reliability+testing+of+the+clinical+pharmacist+recommendation+taxonomy.&rft.au=Hoth%2C+Angela+B%3BCarter%2C+Barry+L%3BNess%2C+Jose%3BBhattacharyya%2C+Anjan%3BShorr%2C+Ronald+I%3BRosenthal%2C+Gary+E%3BKaboli%2C+Peter+J&rft.aulast=Hoth&rft.aufirst=Angela&rft.date=2007-05-01&rft.volume=27&rft.issue=5&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-26 N1 - Date created - 2007-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A critical role of serum response factor in myofibroblast differentiation during experimental oesophageal ulcer healing in rats. AN - 70400797; 17068115 AB - Myofibroblast differentiation is a key event during wound healing and is triggered primarily by transforming growth factor beta (TGFbeta). Serum response factor (SRF) is a TGFbeta-inducible transcription factor that is important for wound healing. Injection of SRF expression plasmid into rat gastric ulcers significantly accelerated restoration of epithelium and smooth muscle structures. To determine the role of SRF in oesophageal ulcer healing, especially in myofibroblast differentiation. Rats (in vivo), oesophageal epithelial cells (Het1A) and fibroblasts (Rat1-R12) (in vitro) were used. Oesophageal ulcers were induced in rats with acetic acid and subsequently treated by local injection of plasmids expressing either SRF or SRF antisense sequence. Rats were killed at 1, 3, 6, 9 and 14 days after treatment and tissues collected. For in vitro studies, both Het1A and Rat1-R12 cells were transfected with the plasmids used in ulcer treatment. Upregulation of SRF increased the myofibroblast population in ulcer granulation tissue; knockdown of SRF suppressed this event. In addition, ulceration induced SRF and TGFbeta expression coordinately. In vitro studies showed that overexpression of SRF in either oesophageal epithelial cells or fibroblasts was sufficient to induce myofibroblast phenotype. Furthermore, the TGFbeta-induced myofibroblast phenotype required integrin-linked kinase (ILK)-mediated SRF activation, as either knockdown of SRF or inactivation of ILK prevented this action. SRF is indispensable for myofibroblast differentiation during oesophageal ulcer healing and is required for TGFbeta-induced myofibroblast transition from either epithelial cells or fibroblasts. ILK is a mediator in TGFbeta-induced SRF activation and subsequent myofibroblast differentiation. ILK is associated with SRF, and TGFbeta enhances this association. JF - Gut AU - Chai, Jianyuan AU - Norng, Manith AU - Tarnawski, Andrzej S AU - Chow, Justine AD - Department of Research (151), VA Long Beach Healthcare System, 5901 E 7th St, Long Beach, CA 90822, USA. jianyuan.chai@med.va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 621 EP - 630 VL - 56 IS - 5 SN - 0017-5749, 0017-5749 KW - Recombinant Proteins KW - 0 KW - Serum Response Factor KW - Transforming Growth Factor beta KW - integrin-linked kinase KW - EC 2.7.1.- KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Acetic Acid KW - Q40Q9N063P KW - Abridged Index Medicus KW - Index Medicus KW - Transforming Growth Factor beta -- pharmacology KW - Animals KW - Recombinant Proteins -- pharmacology KW - Protein-Serine-Threonine Kinases -- metabolism KW - Dose-Response Relationship, Drug KW - Wound Healing KW - Cell Differentiation KW - Epithelial Cells -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Transforming Growth Factor beta -- physiology KW - Epithelial Cells -- drug effects KW - Cells, Cultured KW - Transforming Growth Factor beta -- metabolism KW - Male KW - Protein-Serine-Threonine Kinases -- physiology KW - Ulcer -- therapy KW - Fibroblasts -- drug effects KW - Esophageal Diseases -- pathology KW - Fibroblasts -- pathology KW - Ulcer -- chemically induced KW - Serum Response Factor -- genetics KW - Serum Response Factor -- physiology KW - Ulcer -- metabolism KW - Genetic Therapy -- methods KW - Esophageal Diseases -- metabolism KW - Ulcer -- pathology KW - Esophageal Diseases -- therapy KW - Fibroblasts -- metabolism KW - Esophageal Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70400797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gut&rft.atitle=A+critical+role+of+serum+response+factor+in+myofibroblast+differentiation+during+experimental+oesophageal+ulcer+healing+in+rats.&rft.au=Chai%2C+Jianyuan%3BNorng%2C+Manith%3BTarnawski%2C+Andrzej+S%3BChow%2C+Justine&rft.aulast=Chai&rft.aufirst=Jianyuan&rft.date=2007-05-01&rft.volume=56&rft.issue=5&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Gut&rft.issn=00175749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-29 N1 - Date created - 2007-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Circ Res. 2000 Feb 4;86(2):221-32 [10666419] J Biol Chem. 2006 Aug 25;281(34):24863-72 [16728409] Am J Pathol. 2001 Oct;159(4):1465-75 [11583974] J Biol Chem. 2001 Oct 26;276(43):40033-40 [11514558] J Cell Biol. 2002 Jan 7;156(1):161-72 [11781340] Gastroenterology. 2002 Feb;122(2):458-68 [11832460] J Cell Biol. 2002 Feb 18;156(4):737-50 [11839767] Am J Pathol. 2002 Mar;160(3):963-72 [11891194] Nat Rev Mol Cell Biol. 2002 May;3(5):349-63 [11988769] J Physiol Pharmacol. 2002 Jun;53(2):147-57 [12120892] Am J Pathol. 2002 Oct;161(4):1101-5 [12368182] Am J Pathol. 2002 Oct;161(4):1449-57 [12368217] Exp Cell Res. 2003 Jan 15;282(2):90-100 [12531695] J Biol Chem. 2003 Jul 11;278(28):25808-15 [12736251] Am J Respir Cell Mol Biol. 2003 Nov;29(5):583-90 [12777247] J Mol Cell Cardiol. 2003 Dec;35(12):1407-20 [14654367] Biochem Biophys Res Commun. 2004 Apr 16;316(4):997-1001 [15044083] Gastroenterology. 2004 Jun;126(7):1809-18 [15188176] FASEB J. 2004 Aug;18(11):1264-6 [15180964] Gastroenterology. 1977 Dec;73(6):1315-9 [913973] Virology. 1981 Aug;113(1):408-11 [7269249] Cell. 1986 Aug 15;46(4):567-74 [3524858] Cancer Res. 1991 Jan 1;51(1):365-71 [1703038] EMBO J. 1992 Jan;11(1):97-105 [1740119] J Cell Biol. 1993 Jul;122(1):103-11 [8314838] Mol Cell Biol. 1993 Oct;13(10):6260-73 [8413226] Am J Physiol. 1994 May;266(5 Pt 1):G878-86 [8203532] J Physiol Pharmacol. 1996 Sep;47(3):443-54 [8877900] Gut. 1996 Aug;39(2):172-5 [8991853] Dig Dis Sci. 1997 Mar;42(3):616-25 [9073148] J Mol Cell Cardiol. 1998 Mar;30(3):551-62 [9515031] Science. 1999 Jan 1;283(5398):83-7 [9872747] Development. 1999 May;126(10):2053-62 [10207131] J Biol Chem. 1999 May 14;274(20):14434-43 [10318869] Am J Physiol. 1999 Jul;277(1 Pt 1):C1-9 [10409103] J Physiol Pharmacol. 2005 Mar;56(1):3-13 [15795471] Am J Pathol. 2005 May;166(5):1343-51 [15855636] Gastroenterology. 2005 Jun;128(7):1984-95 [15940631] Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31 [16493410] Cardiovasc Res. 2006 Apr 1;70(1):136-45 [16451796] J Biol Chem. 2006 Jul 21;281(29):20383-92 [16690609] EMBO J. 2000 Sep 15;19(18):4955-66 [10990459] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Upward pressures on drinking: exposure and reactivity in adulthood. AN - 70395284; 17446984 AB - The purpose of this study was to identify the situations most commonly linked with increased drinking for different life periods and for nonproblem and problem drinkers. A community sample of older adults (average age 69 years; 42% women), consisting of 480 nonproblem and 351 problem drinkers, provided information about their life history of drinking. For each of three life periods (early adulthood, early middle age, and late middle age), respondents indicated whether they experienced particular situations (exposure) and, if so, whether they increased their alcohol consumption in response to these situations (reactivity). These situations included social influences and stressors. Exposure to social influences and to stressors varied across life periods, as did drinking reactivity. Overall, the social influences of having peers or a partner who drank and the stressors of family interpersonal problems and emotional distress were common experiences and also were among the most likely to be linked with increased alcohol consumption. Compared with nonproblem drinkers, problem drinkers reported significantly higher levels of exposure to social influences and to stressors and also were much more reactive to them. Prevention and treatment of alcohol use disorders can be tailored to take into account variations in exposure and reactivity to situations that may place upward pressure on drinking. JF - Journal of studies on alcohol and drugs AU - Lemke, Sonne AU - Brennan, Penny L AU - Schutte, Kathleen K AU - Moos, Rudolf H AD - Department of Veterans Affairs, Center for Health Care Evaluation, Menlo Park, CA 94025, USA. sonne.lemke@va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 437 EP - 445 VL - 68 IS - 3 SN - 1937-1888, 1937-1888 KW - Index Medicus KW - Emotions KW - Arousal KW - Risk Factors KW - Humans KW - Adult KW - Retrospective Studies KW - Alcohol Drinking -- psychology KW - Aged KW - Middle Aged KW - Social Facilitation KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Motivation KW - Life Change Events KW - Alcoholism -- psychology KW - Alcoholism -- prevention & control KW - Social Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70395284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol+and+drugs&rft.atitle=Upward+pressures+on+drinking%3A+exposure+and+reactivity+in+adulthood.&rft.au=Lemke%2C+Sonne%3BBrennan%2C+Penny+L%3BSchutte%2C+Kathleen+K%3BMoos%2C+Rudolf+H&rft.aulast=Lemke&rft.aufirst=Sonne&rft.date=2007-05-01&rft.volume=68&rft.issue=3&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol+and+drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-16 N1 - Date created - 2007-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protective role of intracellular zinc in myocardial ischemia/reperfusion is associated with preservation of protein kinase C isoforms. AN - 70393014; 17322024 AB - The recent discovery of zinc signals and their essential role in the redox signaling network implies that zinc homeostasis and the function of zinc-containing proteins are probably altered as a result of oxidative stress, suggesting new targets for pharmacological intervention. We hypothesized that the level of intracellular labile zinc is changed in hearts subjected to ischemia/reperfusion (I/R) and investigated whether the maintenance of myocardial zinc status protected heart functions. Using fluorescent imaging, we demonstrated decreased levels of labile zinc in the I/R hearts. Phorbol 12-myristate 13-acetate, a known trigger of zinc release, liberated zinc ions in control hearts but failed to produce any increase in zinc levels in the I/R rat hearts. Adding the zinc ionophore pyrithione at reperfusion improved myocardial recovery up to 100% and reduced the incidence of arrhythmias more than 2-fold. This effect was dose-dependent, and high concentrations of zinc were toxic. Adding membrane-impermeable zinc chloride was ineffective. Hearts from rats receiving zinc pyrithione supplements in their diet fully recovered from I/R. The recovery was associated with the prevention of degradation of the two protein kinase C isoforms, delta and epsilon, during I/R. In conclusion, our results suggest a protective role of intracellular zinc in myocardial recovery from oxidative stress imposed by I/R. The data support the potential clinical use of zinc ionophores in the settings of acute redox stress in the heart. JF - The Journal of pharmacology and experimental therapeutics AU - Karagulova, Gulnura AU - Yue, Yuankun AU - Moreyra, Abel AU - Boutjdir, Mohamed AU - Korichneva, Irina AD - Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903, and Molecular and Cellular Cardiology Program, Veterans Administration New York Harbor Healthcare System, New York, NY, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 517 EP - 525 VL - 321 IS - 2 SN - 0022-3565, 0022-3565 KW - Metallothionein KW - 9038-94-2 KW - Prkcd protein, rat KW - EC 2.7.1.- KW - Prkce protein, rat KW - Protein Kinase C-delta KW - EC 2.7.11.13 KW - Protein Kinase C-epsilon KW - Zinc KW - J41CSQ7QDS KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Metallothionein -- biosynthesis KW - Myocardium -- chemistry KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Male KW - Zinc -- analysis KW - Zinc -- physiology KW - Protein Kinase C-delta -- physiology KW - Protein Kinase C-epsilon -- physiology KW - Myocardial Reperfusion Injury -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70393014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Protective+role+of+intracellular+zinc+in+myocardial+ischemia%2Freperfusion+is+associated+with+preservation+of+protein+kinase+C+isoforms.&rft.au=Karagulova%2C+Gulnura%3BYue%2C+Yuankun%3BMoreyra%2C+Abel%3BBoutjdir%2C+Mohamed%3BKorichneva%2C+Irina&rft.aulast=Karagulova&rft.aufirst=Gulnura&rft.date=2007-05-01&rft.volume=321&rft.issue=2&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2007-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lepirudin for anticoagulation in patients with heparin-induced thrombocytopenia treated with continuous renal replacement therapy. AN - 70365316; 17109386 AB - Lepirudin is a potent, direct thrombin inhibitor used for anticoagulation in patients with heparin-induced thrombocytopenia type II (HIT). The half-life of lepirudin is prolonged in patients with renal insufficiency. Preliminary studies suggest that it is safe to use lepirudin in patients being treated with intermittent hemodialysis but information regarding its use with continuous renal replacement therapy (CRRT) is scarce. CRRT is used in acute care settings to remove fluid and uremic toxins in patients with renal failure with hemodynamic instability. Patients with HIT, renal failure, and hemodynamic instability pose a complex situation for clinical management. These patients require anticoagulation with nonheparin agents with simultaneous CRRT. There are no guidelines in the literature regarding the management of this patient group. We report our experience with lepirudin at managing four such patients with HIT, being treated with CRRT. (c) 2006 Wiley-Liss, Inc. JF - American journal of hematology AU - Gajra, Ajeet AU - Vajpayee, Neerja AU - Smith, Arienne AU - Poiesz, Bernard J AU - Narsipur, Sriram AD - Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York, USA. ajeet.gajra@med.va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 391 EP - 393 VL - 82 IS - 5 SN - 0361-8609, 0361-8609 KW - Anticoagulants KW - 0 KW - Hirudins KW - Recombinant Proteins KW - Heparin KW - 9005-49-6 KW - lepirudin KW - Y43GF64R34 KW - Index Medicus KW - Humans KW - Retrospective Studies KW - Aged KW - Multiple Organ Failure -- blood KW - Multiple Organ Failure -- etiology KW - Drug Evaluation KW - Systemic Inflammatory Response Syndrome -- complications KW - Half-Life KW - Postoperative Complications KW - Aged, 80 and over KW - Middle Aged KW - Recombinant Proteins -- therapeutic use KW - Female KW - Male KW - Systemic Inflammatory Response Syndrome -- blood KW - Purpura, Thrombocytopenic, Idiopathic -- drug therapy KW - Kidney Failure, Chronic -- blood KW - Anticoagulants -- therapeutic use KW - Renal Dialysis -- methods KW - Kidney Failure, Chronic -- therapy KW - Purpura, Thrombocytopenic, Idiopathic -- chemically induced KW - Kidney Failure, Chronic -- etiology KW - Heparin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70365316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hematology&rft.atitle=Lepirudin+for+anticoagulation+in+patients+with+heparin-induced+thrombocytopenia+treated+with+continuous+renal+replacement+therapy.&rft.au=Gajra%2C+Ajeet%3BVajpayee%2C+Neerja%3BSmith%2C+Arienne%3BPoiesz%2C+Bernard+J%3BNarsipur%2C+Sriram&rft.aulast=Gajra&rft.aufirst=Ajeet&rft.date=2007-05-01&rft.volume=82&rft.issue=5&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hematology&rft.issn=03618609&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-31 N1 - Date created - 2007-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship Abuse and Victims Posttraumatic Stress Disorder Symptoms: Associations with Child Behavior Problems AN - 61399089; 200705374 AB - This study examined associations among male-to-female physical and psychological relationship aggression. Male partners PTSD symptoms, and behavior problems among the children (n=62) of men enrolled in a treatment program for relationship abuse perpetration. Psychological aggression was a stronger predictor of child behavior problems than physical assault. Restrictive engulfment and hostile withdrawal behaviors evidenced the strongest bivariate associations with child behavior problems, and were the strongest predictors of this outcome when considering four distinct forms of psychological aggression together. Victim PTSD symptoms largely mediated the effects of psychological aggression on child behavior. Findings suggest that male-to-female psychological aggression and victim PTSD symptoms play an important role in understanding behavior problems among children living with male relationship abuse perpetrators. Adapted from the source document. JF - Journal of Family Violence AU - Panuzio, Jillian AU - Taft, Casey T AU - Black, Danielle A AU - Koenen, Karestan C AU - Murphy, Christopher M AD - National Center for PTSD, VA Boston Healthcare System (116B-2), 150 South Huntington Avenue, Boston, MA 02130, USA E-mail: casey.taft@va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 177 EP - 185 PB - Springer Science+Business Media, Inc, New York, NY VL - 22 IS - 4 SN - 0885-7482, 0885-7482 KW - Relationship abuse, Child behavior, Posttraumatic stress disorder, Psychological aggression KW - Aggression KW - Posttraumatic Stress Disorder KW - Child Abuse KW - Behavior Problems KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61399089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Violence&rft.atitle=Relationship+Abuse+and+Victims+Posttraumatic+Stress+Disorder+Symptoms%3A+Associations+with+Child+Behavior+Problems&rft.au=Panuzio%2C+Jillian%3BTaft%2C+Casey+T%3BBlack%2C+Danielle+A%3BKoenen%2C+Karestan+C%3BMurphy%2C+Christopher+M&rft.aulast=Panuzio&rft.aufirst=Jillian&rft.date=2007-05-01&rft.volume=22&rft.issue=4&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Violence&rft.issn=08857482&rft_id=info:doi/10.1007%2Fs10896-007-9069-z LA - English DB - Social Services Abstracts N1 - Date revised - 2007-12-10 N1 - Number of references - 80 N1 - Last updated - 2016-09-28 N1 - CODEN - JFVIEV N1 - SubjectsTermNotLitGenreText - Behavior Problems; Child Abuse; Posttraumatic Stress Disorder; Aggression DO - http://dx.doi.org/10.1007/s10896-007-9069-z ER - TY - JOUR T1 - A review of marital rape AN - 57225263; 200717466 AB - The current paper represents a comprehensive review of marital rape, including its legal history and numerous aspects of its perpetration and victimization. Specifically, this review focuses on theories and forms of marital rape, the scope of the problem, risk factors, resistance strategies, and marital rape's psychological and physical effects, and help-seeking behaviors and interventions for victims. Historically, marital rape has not been recognized as a criminal act, only recently has marital rape become illegal in all 50 states. Marital rape is a serious societal issue that is experienced by 10% to 14% of all married women and 40% to 50% of battered women. Marriages in which marital rape occurs have significantly higher rates of non-sexual violence and marital dissatisfaction, as well as lower ratings of marital quality. Victims who resist marital rape often employ verbal means of resistance. However, most of marital rape victims are either unable or afraid to resist sexual aggression by their husbands. Victims of marital rape experience significant levels of posttraumatic stress disorder (PTSD), depression, gynecological problems, and negative physical health symptoms. Victims of marital rape seek help from a variety of different resources. Seeking help from social service agencies and the law appears to be the most effective behaviors for ending marital rape. Stress inoculation therapy and cognitive processing therapy are promising treatments for victims of marital rape. The literature on marital rape is characterized by considerable methodological problems, and further research is needed to gain a better understanding of this problem. [Copyright 2006 Elsevier Ltd.] JF - Agression and Violent Behavior AU - Martin, Elaine K AU - Taft, Casey T AU - Resick, Patricia A AD - National Center for PTSD, VA Boston Healthcare System, MA Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 329 EP - 347 PB - Elsevier Ltd, Amsterdam The Netherlands VL - 12 IS - 3 SN - 1359-1789, 1359-1789 KW - Domestic violence KW - Health problems KW - Psychological disorders KW - Victimization KW - Helpseeking KW - Marital rape KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57225263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Agression+and+Violent+Behavior&rft.atitle=A+review+of+marital+rape&rft.au=Martin%2C+Elaine+K%3BTaft%2C+Casey+T%3BResick%2C+Patricia+A&rft.aulast=Martin&rft.aufirst=Elaine&rft.date=2007-05-01&rft.volume=12&rft.issue=3&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Agression+and+Violent+Behavior&rft.issn=13591789&rft_id=info:doi/10.1016%2Fj.avb.2006.10.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-09-28 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Marital rape; Victimization; Helpseeking; Domestic violence; Health problems; Psychological disorders DO - http://dx.doi.org/10.1016/j.avb.2006.10.003 ER - TY - JOUR T1 - Statutory reform is associated with improved court practice: results of a tri-state comparison AN - 57093418; 200802712 AB - Purpose: This study investigates the impact of statutory reform in adult guardianship on court practice. Methods Case files for 298 cases of adult guardianship were reviewed in three states with varying degrees of statutory reform: MA (no reform), PA (major amendments in 1992), and CO (full re-enactment of statute per UGPPA in 2000). Five court practices associated with progressive statutory reform were studied: (1) diversion to less restrictive alternatives; (2) minimal and appropriate use of emergency procedures; (3) presence of the alleged incapacitated person at the hearing; (4) use of functional evaluation; (5) use of limited orders. Results CO more frequently utilized all five practices, whereas PA used diversion to less restrictive alternatives and less frequent emergency procedures, but not other practices. MA files rarely showed evidence for use of any of these reforms. Implications Statutory reform may improve court practice. More study of the effects of reform on court practices, and the vulnerable adults served by these courts, is needed. [Copyright 2007 John Wiley and Sons, Ltd.] JF - Behavioral Sciences & the Law AU - Moye, Jennifer AU - Wood, Erica AU - Edelstein, Barry AU - Wood, Stacey AU - Bower, Emily H AU - Harrison, Julie A AU - Armesto, Jorge C Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 425 EP - 436 PB - John Wiley & Sons, Chichester UK VL - 25 IS - 3 SN - 0735-3936, 0735-3936 KW - Statutory procedures KW - Court orders KW - Guardianship KW - Adults KW - Vulnerable people KW - Reforms KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57093418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sciences+%26+the+Law&rft.atitle=Statutory+reform+is+associated+with+improved+court+practice%3A+results+of+a+tri-state+comparison&rft.au=Moye%2C+Jennifer%3BWood%2C+Erica%3BEdelstein%2C+Barry%3BWood%2C+Stacey%3BBower%2C+Emily+H%3BHarrison%2C+Julie+A%3BArmesto%2C+Jorge+C&rft.aulast=Moye&rft.aufirst=Jennifer&rft.date=2007-05-01&rft.volume=25&rft.issue=3&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sciences+%26+the+Law&rft.issn=07353936&rft_id=info:doi/10.1002%2Fbsl.762 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - BSLADR N1 - SubjectsTermNotLitGenreText - Guardianship; Adults; Statutory procedures; Reforms; Court orders; Vulnerable people DO - http://dx.doi.org/10.1002/bsl.762 ER - TY - JOUR T1 - Intelligence in early adulthood and life span up to 65 years later in male elderly twins AN - 57061820; 200718982 AB - Background: previous research has reported that greater intelligence in early life is associated with longer lifespan. Whether this relationship is mediated by genetic factors or environmental factors, some of which could be modified by an individual, is unclear. Objective: we examined the association between intelligence test scores, obtained during the 1940s, and age at death in a group of 492 male twin pairs, members of the National Academy of Sciences -- National Research Council Twins Registry of WWII veterans. Design: using self-report information collected in the 1960s, we examined whether modifiable risk factors for mortality, such as use of tobacco and alcohol, cardiovascular disease, and body mass index altered the association between intelligence and longevity. Results: when each member of a twin pair was treated as an independent observation, higher intelligence test scores were associated with longer life span (P = 0.0002). Modifiable risk factors were associated with life span as expected. However, in co-twin control analyses in which one twin served as the control for the other twin, neither intelligence nor any modifiable risk factors showed a significant association with life span. Conclusion: our findings suggest that genetics and early life environmental factors contribute heavily to lifespan and when one controls for these factors using twins, the effect of intelligence on longevity is diminished. Adapted from the source document. JF - Age and Ageing AU - Holsinger, Tracey AU - Helms, Michael AU - Plassman, Brenda AD - Durham VA Medical Center, NC, USA tracey.holsinger@med.va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 286 EP - 291 PB - Oxford University Press, UK VL - 36 IS - 3 SN - 0002-0729, 0002-0729 KW - intelligence, survival, twins, risk factors, elderly KW - Elderly people KW - Intelligence KW - Twins KW - Risk factors KW - Longevity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57061820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Age+and+Ageing&rft.atitle=Intelligence+in+early+adulthood+and+life+span+up+to+65+years+later+in+male+elderly+twins&rft.au=Holsinger%2C+Tracey%3BHelms%2C+Michael%3BPlassman%2C+Brenda&rft.aulast=Holsinger&rft.aufirst=Tracey&rft.date=2007-05-01&rft.volume=36&rft.issue=3&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Age+and+Ageing&rft.issn=00020729&rft_id=info:doi/10.1093%2Fageing%2Fafm016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Intelligence; Twins; Risk factors; Elderly people; Longevity DO - http://dx.doi.org/10.1093/ageing/afm016 ER - TY - JOUR T1 - Effects of Subchronic Lithium Treatment on Levels of BDNF, Bcl-2 and Phospho-CREB in the Rat Hippocampus AN - 21061287; 7910950 AB - Abstract: Although it has been proposed that exposure to lithium up-regulates brain-derived neurotrophic factor (BDNF), B-cell leukaemia/lymphoma 2 protein (Bcl-2) and cyclic AMP-response element-binding protein (CREB), and these molecules are involved in the neuroplastic actions and clinical efficacy of the drug, the several lines of evidence suggest that the lithium-induced up-regulation of these molecules has not been consistently confirmed. Few studies have examined the effects of lithium exposure on the regulation of these molecules in the dentate gyrus (DG) and area CA1 in the hippocampus. We examined the effects of subchronic lithium treatment on the levels of BDNF, Bcl-2 and phosphorylated CREB in the DG and area CA1. We administered LiCl intraperitoneally (1 mEq/kg per day) to adult rats for 14 days, killed animals in 24 hr after the last administration of the drug, and determined the tissue levels of BDNF, Bcl-2 and pCREB in the DG and area CA1. Subchronic lithium treatment for 14 days did not significantly alter the levels of BDNF, Bcl-2 or phosphorylated CREB in the DG and area CA1 in the hippocampus. This study indicates that the lithium-induced up-regulation of these molecules may be various depending on the duration of lithium exposure and particular brain regions exposed to the drug. JF - Basic & Clinical Pharmacology & Toxicology AU - Hammonds, Michael D AU - Shim, Seong S AU - Feng, Pingfu AU - Calabrese, Joseph R AD - Cleveland Department of Veterans Affairs Medical Center,, seong.shim@med.va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 356 EP - 359 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 100 IS - 5 SN - 1742-7835, 1742-7835 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Brain-derived neurotrophic factor KW - Leukemia KW - Hippocampus KW - Lymphocytes B KW - Lithium chloride KW - Bcl-2 protein KW - Drugs KW - Lymphoma KW - Lithium KW - Dentate gyrus KW - Cyclic AMP response element-binding protein KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21061287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+%26+Clinical+Pharmacology+%26+Toxicology&rft.atitle=Effects+of+Subchronic+Lithium+Treatment+on+Levels+of+BDNF%2C+Bcl-2+and+Phospho-CREB+in+the+Rat+Hippocampus&rft.au=Hammonds%2C+Michael+D%3BShim%2C+Seong+S%3BFeng%2C+Pingfu%3BCalabrese%2C+Joseph+R&rft.aulast=Hammonds&rft.aufirst=Michael&rft.date=2007-05-01&rft.volume=100&rft.issue=5&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=Basic+%26+Clinical+Pharmacology+%26+Toxicology&rft.issn=17427835&rft_id=info:doi/10.1111%2Fj.1742-7843.2007.00058.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Brain-derived neurotrophic factor; Leukemia; Lymphocytes B; Hippocampus; Lithium chloride; Bcl-2 protein; Lymphoma; Drugs; Dentate gyrus; Lithium; Cyclic AMP response element-binding protein DO - http://dx.doi.org/10.1111/j.1742-7843.2007.00058.x ER - TY - JOUR T1 - An outbreak of infections caused by non-typeable Haemophilus influenzae in an extended care facility AN - 20913843; 8337587 AB - Nosocomial outbreaks of infection due to non-typeable Haemophilus influenzae (NTHi) are rarely described. There are a few published reports that suggest that elderly patients with underlying pulmonary disease are at risk and that person-to-person spread is key to disease transmission. During the summer months of 2005, we documented an outbreak of NTHi infections in a Veterans Affairs nursing home. Thirteen patients developed conjunctivitis or lower respiratory infection involving a beta -lactamase-negative biotype III NTHi isolate, with an indistinguishable SmaI macrorestriction pattern. Patients were elderly males usually with underlying cardiac and pulmonary disease. A case-control study failed to demonstrate any specific significant risk factor for NTHi infection and there was no evidence of spatial clustering of cases within the nursing home. A random throat culture survey involving nursing home patients during the outbreak showed that only one of 19 persons was colonized with NTHi. The outbreak concluded following appropriate treatment and an emphasis on universal and respiratory droplet precautions. All patients recovered and a specific inciting event for the outbreak was never defined. Literature review revealed a spectrum of responses to nosocomial NTHi infections and a lack of consensus regarding the infection control approach towards NTHi outbreaks. JF - Journal of Hospital Infection AU - Van Dort, M AU - Walden, C AU - Walker, E S AU - Reynolds, S A AU - Levy, F AU - Sarubbi, F A AD - James H. Quillen Veterans Affairs Medical Center, Mountain Home, Tennessee, USA, felix.sarubbi@med.va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 59 EP - 64 PB - W.B. Saunders Company, Periodicals Order Fulfillment Dept. 6277 Sea Harbor Drive Orlando, FL 32887-4800 USA, [mailto:hhspcs@harcourt.com], [URL:http://www.wbsaunders.com] VL - 66 IS - 1 SN - 0195-6701, 0195-6701 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Non-typeable Haemophilus influenzae KW - Extended care outbreak KW - Case-control study KW - Haemophilus influenzae KW - Biotypes KW - Pharynx KW - Respiration KW - Lung diseases KW - Conjunctivitis KW - Infection KW - Disease transmission KW - Nursing KW - Risk factors KW - Geriatrics KW - Hospitals KW - Heart diseases KW - J 02400:Human Diseases KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20913843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hospital+Infection&rft.atitle=An+outbreak+of+infections+caused+by+non-typeable+Haemophilus+influenzae+in+an+extended+care+facility&rft.au=Van+Dort%2C+M%3BWalden%2C+C%3BWalker%2C+E+S%3BReynolds%2C+S+A%3BLevy%2C+F%3BSarubbi%2C+F+A&rft.aulast=Van+Dort&rft.aufirst=M&rft.date=2007-05-01&rft.volume=66&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hospital+Infection&rft.issn=01956701&rft_id=info:doi/10.1016%2Fj.jhin.2007.02.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Pharynx; Biotypes; Risk factors; Respiration; Nursing; Lung diseases; Geriatrics; Conjunctivitis; Infection; Disease transmission; Heart diseases; Hospitals; Haemophilus influenzae DO - http://dx.doi.org/10.1016/j.jhin.2007.02.001 ER - TY - JOUR T1 - CT-Guided Intervention with Low Radiation Dose: Feasibility and Experience AN - 20682036; 10064740 AB - OBJECTIVE. The purpose of this study was to evaluate the feasibility of performing CT-guided interventional procedures with a very low radiation dose. MATERIALS AND METHODS. We performed 291 CT-guided interventional procedures using a low dose of radiation. The subjects were 165 men and 126 women 22-89 years old with a mean age of 65 years. CT fluoroscopy was not used. The procedures were 201 percutaneous biopsies and 90 percutaneous aspiration or drainage procedures. Before the procedure, images were obtained with standard mAs of 175-250 mAs. All subsequent CT was performed at a reduced mAs. Technical success of catheter placement and biopsy was calculated, and the results were compared with those of procedures performed over the previous 12 months with standard radiation doses. Patient weight, lesion size, and number of CT acquisitions needed to complete the procedure were recorded. RESULTS. All but three aspiration or drainage procedures performed at 30 mAs were successful, for a success rate of 96.7%. The technical success rate of biopsy performed at 30 mAs was 93.5%. In the cases of 13 patients undergoing biopsy, the masses were not identified with low-dose technique, and these procedures were completed at a higher dose. Results were independent of patient weight and lesion size. The technical success rate was 98% for percutaneous drainage performed at a standard radiation dose in the 12 months before introduction of the low-dose technique. The technical success rate was 87.5% for biopsy performed at a standard radiation dose in the 12 months before introduction of the low-dose technique. The complication rate of the low-dose technique was comparable to that of the standard-dose technique. CONCLUSION. Low-dose radiation technique using 30 mAs results in technical success for both catheter placement and percutaneous biopsy comparable to standard radiation dose. JF - American Journal of Roentgenology AU - Lucey, B C AU - Varghese, J C AU - Hochberg, A AU - Blake, MA AU - Soto, JA AD - Department of Radiology, Boston Veterans Administration Healthcare System, West Roxbury, MA, USA Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1187 EP - 1194 VL - 188 IS - 5 SN - 0361-803X, 0361-803X KW - Toxicology Abstracts KW - Age KW - Radiation KW - Drainage KW - Catheters KW - Biopsy KW - fluoroscopy KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20682036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Roentgenology&rft.atitle=CT-Guided+Intervention+with+Low+Radiation+Dose%3A+Feasibility+and+Experience&rft.au=Lucey%2C+B+C%3BVarghese%2C+J+C%3BHochberg%2C+A%3BBlake%2C+MA%3BSoto%2C+JA&rft.aulast=Lucey&rft.aufirst=B&rft.date=2007-05-01&rft.volume=188&rft.issue=5&rft.spage=1187&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Roentgenology&rft.issn=0361803X&rft_id=info:doi/10.2214%2FAJR.06.0378 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Radiation; Drainage; Catheters; fluoroscopy; Biopsy DO - http://dx.doi.org/10.2214/AJR.06.0378 ER - TY - JOUR T1 - Osteoarthritis: A Comorbid Marker for Longer Life? AN - 20558666; 9260522 AB - Purpose Diseases are often described and studied in isolation, yet there is increasing recognition of the complex interrelatedness of diseases and treatments in patients with multiple chronic diseases. Our objective was to describe the impact of selected diseases involving chronic inflammation (chronic obstructive pulmonary disease [COPD], osteoarthritis, and rheumatoid arthritis) on mortality. Methods We identified a cohort aged 55 to 64 years with one or more chronic conditions. Clusters of mutually exclusive disease combinations were created. Five-year all-cause mortality was determined and the relative risk (RR) of mortality was estimated when COPD, osteoarthritis, and rheumatoid arthritis were added to clusters. Results In 741,847 persons the 5-year mortality rates were lowest among persons with one condition and increased with more chronic conditions. The presence of osteoarthritis in a cluster was an exception where the risk was lower compared with that cluster without osteoarthritis: COPD (RR = 0.73 [95% confidence interval (CI), 0.6,0.81]); ischemic heart disease (0.63 [0.5,0.76]); hypertension (0.77 [0.7,0.83]); dementia (0.63 [0.4,0.93]); depression (0.65 [0.5,0.84]); hypertension plus diabetes (0.85 [0.7,0.93]); and ischemic heart disease plus hypertension (0.83 [0.7,0.94]). Conclusions The association between osteoarthritis and lower rates of mortality is notable and replicating these findings to explore causal relationships is important. Key Words: Mortality; Comorbidity; Osteoarthritis; COPD; Rheumatoid Arthritis Abbreviations: AHRQ, Agency for Healthcare Research and Quality; CI, confidence interval; COPD, chronic obstructive pulmonary disease; RR, relative risk; VHA, Veterans Health Administration JF - Annals of Epidemiology AU - Lee, Todd A AU - Pickard, A Simon AU - Bartle, Brian AU - Weiss, Kevin B AD - From Midwest Center for Health Services and Policy Research, Hines VA Hospital, Hines, IL (T.A.L., B.B., K.B.W); Institute for Healthcare Studies and Division of General Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago (T.A.L, K.B.W.); and the Department of Pharmacy Practice and Center for Pharmacoeconomic Research, College of Pharmacy, University of Illinois at Chicago (A.S.P.), todd.lee@va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 380 EP - 384 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 17 IS - 5 SN - 1047-2797, 1047-2797 KW - Risk Abstracts; Calcium & Calcified Tissue Abstracts KW - Risk assessment KW - Mortality KW - Depression KW - Osteoarthritis KW - Ischemia KW - depression KW - heart diseases KW - Morbidity KW - Inflammation KW - Chronic obstructive pulmonary disease KW - Diabetes mellitus KW - diabetes mellitus KW - Rheumatoid arthritis KW - Health care KW - rheumatoid arthritis KW - Risk factors KW - hypertension KW - Dementia disorders KW - dementia disorders KW - chronic obstructive pulmonary disease KW - Heart diseases KW - Hypertension KW - T 2030:Cartilage and Cartilage Diseases KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20558666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Osteoarthritis%3A+A+Comorbid+Marker+for+Longer+Life%3F&rft.au=Lee%2C+Todd+A%3BPickard%2C+A+Simon%3BBartle%2C+Brian%3BWeiss%2C+Kevin+B&rft.aulast=Lee&rft.aufirst=Todd&rft.date=2007-05-01&rft.volume=17&rft.issue=5&rft.spage=380&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mortality; Depression; Osteoarthritis; Ischemia; Chronic obstructive pulmonary disease; Inflammation; Diabetes mellitus; Rheumatoid arthritis; Risk factors; Dementia disorders; Hypertension; Heart diseases; diabetes mellitus; Health care; rheumatoid arthritis; hypertension; dementia disorders; depression; Morbidity; heart diseases; chronic obstructive pulmonary disease ER - TY - JOUR T1 - Anaplasma phagocytophilum AnkA is tyrosine-phosphorylated at EPIYA motifs and recruits SHP-1 during early infection AN - 20464346; 7894342 AB - Anaplasma phagocytophilum is an intracellular pathogen that infects and survives in neutrophilic granulocytes. The A. phagocytophilum genome encodes a type four secretion system (T4SS) that may facilitate intracellular survival by translocation of virulence factors, but to date, no such factors have been identified. Because T4SS-translocated proteins of several intracellular organisms undergo tyrosine phosphorylation by host cell kinases, we investigated tyrosine phosphorylation of A. phagocytophilum proteins during infection. Within minutes after incubation of A. phagocytophilum with HL-60 cells or PMN, a 190 kDa bacterial protein, AnkA, was increasingly tyrosine-phosphorylated. A. phagocytophilum binding to host cells without entry was sufficient for AnkA tyrosine phosphorylation. An in vitro Src kinase assay demonstrated that purified AnkA expressed in Escherichia coli was phosphorylated at tyrosines located at the C-terminal portion of AnkA. Similarly, AnkA expressed in COS-7 cells underwent tyrosine phosphorylation by Src at the C-terminus. The phosphorylated tyrosines were located in EPIYA motifs that display the consensus sequence for binding to SH2 domains. Immunoprecipitation studies demonstrated AnkA binding to the host cell phosphatase SHP-1 during early infection. Phosphorylation of the EPIYA motifs and the presence of the SH2 domains were necessary for AnkA-SHP-1 interaction. We conclude that AnkA is a translocated virulence factor that is tyrosine-phosphorylated by host cell kinases upon translocation into the host cell early during infection. A. phagocytophilum may manipulate the host cell through SHP-1 recruitment. JF - Cellular Microbiology AU - IJdo, Jacob W AU - Carlson, Adam C AU - Kennedy, Elizabeth L AD - Inflammation Program and Division of Rheumatology, Department of Internal Medicine, University of Iowa and Veterans Administration Medical Center, Iowa City, IA, USA., jacob-ijdo@uiowa.edu Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1284 EP - 1296 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 5 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Genomes KW - SHP-1 protein KW - virulence factors KW - C-Terminus KW - Immunoprecipitation KW - Tyrosine KW - Pathogens KW - Infection KW - Anaplasma KW - Leukocytes (granulocytic) KW - Phosphorylation KW - Escherichia coli KW - Src protein KW - Conserved sequence KW - Translocation KW - J 02320:Cell Biology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20464346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Anaplasma+phagocytophilum+AnkA+is+tyrosine-phosphorylated+at+EPIYA+motifs+and+recruits+SHP-1+during+early+infection&rft.au=IJdo%2C+Jacob+W%3BCarlson%2C+Adam+C%3BKennedy%2C+Elizabeth+L&rft.aulast=IJdo&rft.aufirst=Jacob&rft.date=2007-05-01&rft.volume=9&rft.issue=5&rft.spage=1284&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2006.00871.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; SHP-1 protein; virulence factors; C-Terminus; Immunoprecipitation; Tyrosine; Pathogens; Infection; Leukocytes (granulocytic); Phosphorylation; Src protein; Conserved sequence; Translocation; Escherichia coli; Anaplasma DO - http://dx.doi.org/10.1111/j.1462-5822.2006.00871.x ER - TY - JOUR T1 - Health and Exposure Concerns of Veterans Deployed to Iraq and Afghanistan AN - 20255732; 7439791 AB - Objective: We report the clinical concerns of US veterans of Operations Iraqi Freedom and Enduring Freedom evaluated at the New Jersey War-Related Illness and Injury Study Center (NJ WRIISC) between June 2004 and January 2006. Methods: We conducted a retrospective chart review of veterans' health and exposure concerns. Results: Veterans (n = 56) reported an average of 4 (standard deviation [SD] = 2.1; range, 0-9) physical health concerns, and 2.7 (SD = 2.3; range, 0-10) exposure concerns. The majority of veterans (55%) had a mental health concern, most commonly, posttraumatic stress disorder. The most common exposure concerns were depleted uranium, multiple vaccinations, and poor air quality. Greater proportions of Reserve veterans reported genitourinary concerns and exposure to smoke from burning trash than active duty veterans. Conclusions: Veterans of military operations in Southwest Asia have deployment-related health and exposure concerns that will need to be addressed by their ambulatory care physicians. JF - Journal of Occupational and Environmental Medicine AU - Helmer, DA AU - Rossignol, M AU - Blatt, M AU - Agarwal, R AU - Teichman, R AU - Lange, G AD - Department of Veterans Affairs, New Jersey, Health Care System, 385 Tremont Avenue, #129, East Orange, NJ 07018, USA, drew.helmer@va.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 475 EP - 480 VL - 49 IS - 5 SN - 1076-2752, 1076-2752 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - USA, New Jersey KW - Injuries KW - Psychology KW - Air quality KW - Afghanistan KW - burning KW - Iraq KW - Smoke KW - Depleted uranium KW - Reviews KW - Radioisotopes KW - Asia KW - Military KW - Occupational exposure KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20255732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Health+and+Exposure+Concerns+of+Veterans+Deployed+to+Iraq+and+Afghanistan&rft.au=Helmer%2C+DA%3BRossignol%2C+M%3BBlatt%2C+M%3BAgarwal%2C+R%3BTeichman%2C+R%3BLange%2C+G&rft.aulast=Helmer&rft.aufirst=DA&rft.date=2007-05-01&rft.volume=49&rft.issue=5&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e318042d682 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Smoke; Depleted uranium; Injuries; Psychology; Reviews; Radioisotopes; Air quality; burning; Military; Occupational exposure; USA, New Jersey; Afghanistan; Asia; Iraq DO - http://dx.doi.org/10.1097/JOM.0b013e318042d682 ER - TY - JOUR T1 - National Survey on the Susceptibility of Bacteroides fragilis Group: Report and Analysis of Trends in the United States from 1997 to 2004 AN - 19972763; 7403168 AB - The susceptibility trends for the species of the Bacteroides fragilis group against various antibiotics from 1997 to 2004 were determined by using data for 5,225 isolates referred by 10 medical centers. The antibiotic test panel included ertapenem, imipenem, meropenem, ampicillin-sulbactam, piperacillin-tazobactam, cefoxitin, clindamycin, moxifloxacin, tigecycline, chloramphenicol, and metronidazole. From 1997 to 2004 there were decreases in the geometric mean (GM) MICs of imipenem, meropenem, piperacillin-tazobactam, and cefoxitin for many of the species within the group. B. distasonis showed the highest rates of resistance to most of the {szligbeta}-lactams. B. fragilis, B. ovatus, and B. thetaiotaomicron showed significantly higher GM MICs and rates of resistance to clindamycin over time. The rate of resistance to moxifloxacin of B. vulgatus was very high (MIC range for the 8-year study period, 38% to 66%). B. fragilis, B. ovatus, and B. distasonis and other Bacteroides spp. exhibited significant increases in the rates of resistance to moxifloxacin over the 8 years. Resistance rates and GM MICs for tigecycline were low and stable during the 5-year period over which this agent was studied. All isolates were susceptible to chloramphenicol (MICs < 16 mu g/ml). In 2002, one isolate resistant to metronidazole (MIC = 64 mu g/ml) was noted. These data indicate changes in susceptibility over time; surprisingly, some antimicrobial agents are more active now than they were 5 years ago. JF - Antimicrobial Agents & Chemotherapy AU - Snydman AU - Jacobus, N V AU - McDermott, LA AU - Ruthazer, R AU - Golan, Y AU - Goldstein, EJC AU - Finegold, S M AU - Harrell, L J AU - Hecht, D W AU - Jenkins, S G AU - Pierson, C AU - Venezia, R AU - Yu, V AU - Rihs, J AU - Gorbach, S L AD - Departments of Medicine, Community Health and Clinical Research, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts. R. M. Alden Research Laboratories, Santa Monica, California. Wadsworth Veterans Administration Hospital, Los Angeles, California. Duke University Medical Center, Durham, North Carolina. Loyola University Medical Center, Maywood, Illinois. Carolinas Medical Center, Charlotte, North Carolina, and Mt. Sinai Medical Center, New York, New York. University of Michigan Medical Center, Ann Arbor, Michigan. Albany Medical Center, Albany, New York. Pittsburgh Veterans Administration Medical Center, Pittsburgh, Pennsylvania Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1649 EP - 1655 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 5 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - piperacillin-tazobactam KW - Bacteroides fragilis KW - Metronidazole KW - Clindamycin KW - Chloramphenicol KW - Data processing KW - tigecycline KW - Ovatus KW - ertapenem KW - Antibiotics KW - Minimum inhibitory concentration KW - Antimicrobial agents KW - Imipenem KW - Moxifloxacin KW - Meropenem KW - Cefoxitin KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19972763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=National+Survey+on+the+Susceptibility+of+Bacteroides+fragilis+Group%3A+Report+and+Analysis+of+Trends+in+the+United+States+from+1997+to+2004&rft.au=Snydman%3BJacobus%2C+N+V%3BMcDermott%2C+LA%3BRuthazer%2C+R%3BGolan%2C+Y%3BGoldstein%2C+EJC%3BFinegold%2C+S+M%3BHarrell%2C+L+J%3BHecht%2C+D+W%3BJenkins%2C+S+G%3BPierson%2C+C%3BVenezia%2C+R%3BYu%2C+V%3BRihs%2C+J%3BGorbach%2C+S+L&rft.aulast=Snydman&rft.aufirst=&rft.date=2007-05-01&rft.volume=51&rft.issue=5&rft.spage=1649&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - piperacillin-tazobactam; Metronidazole; Chloramphenicol; Clindamycin; Data processing; tigecycline; ertapenem; Antibiotics; Minimum inhibitory concentration; Imipenem; Antimicrobial agents; Moxifloxacin; Meropenem; Cefoxitin; Bacteroides fragilis; Ovatus ER - TY - JOUR T1 - Anti-p19 Antibody Treatment Exacerbates Lyme Arthritis and Enhances Borreliacidal Activity AN - 19664270; 7416931 AB - Considerable effort has been made to elucidate the mechanism of Lyme arthritis. We focused on p19, a cell cycle-regulating molecule, because it is known to inhibit cell cycle division of T lymphocytes which may be responsible for the induction of arthritis. We show that anti-p19 antibody treatment enhances the inflammatory response normally detected at the tibiotarsal joints of Borrelia burgdorferi-vaccinated and Borrelia bissettii-challenged mice. Specifically, anti-p19 antibody treatment augmented the severity of inflammation within the synovial and subsynovial tissue. Moreover, treatment with anti-p19 antibody caused severe erosion of cartilage and bone with ankle joint destruction. In addition, anti-p19 antibody treatment of Borrelia-vaccinated and -challenged mice enhanced the borreliacidal antibody response, especially against the vaccine isolate. The novel activities of anti-p19 antibody show that p19 may be an important therapeutic site for the treatment of Lyme arthritis. JF - Clinical and Vaccine Immunology AU - Peterson, Sara Heil AU - Nardelli, Dean T AU - Warner, Thomas F AU - Callister, Steven M AU - Torrealba, Jose R AU - Schell, Ronald F AD - Wisconsin State Laboratory of Hygiene. Departments of Bacteriology. Medical Microbiology and Immunology. Pathobiological Sciences, University of Wisconsin. Department of Pathology, Veterans Administration Hospital, Madison, Wisconsin. Microbiology Research Laboratory and Section of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, Wisconsin Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 510 EP - 517 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 14 IS - 5 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Borrelia burgdorferi KW - Cartilage KW - Cell cycle KW - Joint diseases KW - Antibody response KW - Inflammation KW - Bone KW - Arthritis KW - Lymphocytes T KW - Borrelia KW - Ankle KW - Vaccines KW - J 02350:Immunology KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19664270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Anti-p19+Antibody+Treatment+Exacerbates+Lyme+Arthritis+and+Enhances+Borreliacidal+Activity&rft.au=Peterson%2C+Sara+Heil%3BNardelli%2C+Dean+T%3BWarner%2C+Thomas+F%3BCallister%2C+Steven+M%3BTorrealba%2C+Jose+R%3BSchell%2C+Ronald+F&rft.aulast=Peterson&rft.aufirst=Sara&rft.date=2007-05-01&rft.volume=14&rft.issue=5&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Bone; Cartilage; Arthritis; Cell cycle; Lymphocytes T; Joint diseases; Ankle; Antibody response; Vaccines; Inflammation; Borrelia burgdorferi; Borrelia ER - TY - JOUR T1 - Polymyxin antibiotics for gram-negative infections. AN - 70365855; 17420197 AB - The role of polymyxin antibiotics in the treatment of multidrug-resistant gram-negative infections is reviewed. Antimicrobial resistance is an increasing problem across hospitals worldwide, especially in intensive care settings, where nosocomial infections are 5-10 times more likely to occur than on the general wards. The polymyxins, a group of basic polypeptide antibiotics, were first isolated from Bacillus species in the late 1940s and appear to have a surface detergent effect, making them active against most gram-negative organisms. Early clinical reports suggested a high rate of toxicity associated with the polymyxins, specifically nephrotoxicity (20%) and neurotoxicity (7%); thus the polymyxins had largely fallen out of favor. However, recent studies have suggested that the toxicities associated with the polymyxins may be less severe and less frequent than earlier reports. The emergence of multidrug-resistant gram-negative organisms has led to a reemergence in the use of this antibiotic class. Various clinical trials that evaluated the polymyxins for the treatment of multidrug-resistant gram-negative organisms found that these antibiotics have acceptable effectiveness and may be used if necessary. The polymyxins have become a last resort for the treatment of infections caused by multidrug-resistant gram-negative organisms. Recent studies have suggested that the frequency of polymyxin-associated nephrotoxicity and neurotoxicity may not be as high as was once thought. The polymyxins seem to be effective in treating various infections caused by multidrug-resistant gram-negative organisms but should not be used as first-line therapy until more is known about this class of antibiotics. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Arnold, Tamra M AU - Forrest, Graeme N AU - Messmer, Karen J AD - Richard L. Roudebush Veterans Affairs Medical Center (VAMC), Indianapolis, IN 46202, and School of Medicine, University of Maryland, Baltimore, USA. tamra.arnold@va.gov Y1 - 2007/04/15/ PY - 2007 DA - 2007 Apr 15 SP - 819 EP - 826 VL - 64 IS - 8 SN - 1079-2082, 1079-2082 KW - Anti-Bacterial Agents KW - 0 KW - Polymyxins KW - Index Medicus KW - Humans KW - Cross Infection -- drug therapy KW - Drug Synergism KW - Microbial Sensitivity Tests KW - Gram-Negative Bacteria -- drug effects KW - Hospitals KW - Anti-Bacterial Agents -- therapeutic use KW - Polymyxins -- therapeutic use KW - Anti-Bacterial Agents -- adverse effects KW - Gram-Negative Bacterial Infections -- drug therapy KW - Drug Resistance, Multiple, Bacterial KW - Polymyxins -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70365855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Polymyxin+antibiotics+for+gram-negative+infections.&rft.au=Arnold%2C+Tamra+M%3BForrest%2C+Graeme+N%3BMessmer%2C+Karen+J&rft.aulast=Arnold&rft.aufirst=Tamra&rft.date=2007-04-15&rft.volume=64&rft.issue=8&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-05 N1 - Date created - 2007-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat. AN - 70259229; 17292337 AB - It has been shown using in vitro techniques that BDNF and NGF evoke neurotransmitter release in the hippocampus but this phenomenon has not been demonstrated in vivo to date. We therefore performed in vivo microdialysis in urethane-anesthetized Fischer 344 rats. The microdialysis probe was implanted stereotaxically into the CA1 area of the hippocampus. Three hours after the implantation of the probe, glutamate (Glu) and dopamine (DA) levels had reached a stable baseline. Four baseline samples were collected every 15 min at a flow rate of 1 microL/min. The growth factors were delivered (1 microL/10 min) using a microinjector attached to the microdialysis probe. We found that BDNF and NGF, when administered into the hippocampus, evoked dopamine and glutamate release in a dose-dependent fashion. NGF produced a biphasic response in the release of Glu, and a uniphasic response in the release of DA, both of which were calcium dependent. The neurotransmitter release induced by NGF was blocked by tetrodotoxin, indicating neuronal origin of this response. The BDNF induced release of DA and Glu was decreased in low calcium conditions, indicating that it is at least partially calcium dependent. Furthermore, BDNF-induced neurotransmitter release was partially blocked by pre-treatment with K252a, an antagonist for tyrosine kinase receptors, indicating that BDNF is acting through Trk receptors to induce neurotransmitter release. These results demonstrate a close relationship between the growth factors BDNF and NGF and the neurotransmitters DA and Glu in the hippocampus of intact animals. JF - Brain research AU - Paredes, D AU - Granholm, A-Ch AU - Bickford, P C AD - James A. Haley, Veterans Administration Hospital, Tampa, FL, USA. Y1 - 2007/04/13/ PY - 2007 DA - 2007 Apr 13 SP - 56 EP - 64 VL - 1141 SN - 0006-8993, 0006-8993 KW - Brain-Derived Neurotrophic Factor KW - 0 KW - Carbazoles KW - Enzyme Inhibitors KW - Indole Alkaloids KW - Glutamic Acid KW - 3KX376GY7L KW - Nerve Growth Factor KW - 9061-61-4 KW - staurosporine aglycone KW - 97161-97-2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Microdialysis KW - Electrochemistry -- methods KW - Animals KW - Rats, Inbred F344 KW - Drug Interactions KW - Area Under Curve KW - Chromatography, High Pressure Liquid -- methods KW - Carbazoles -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Male KW - Indole Alkaloids -- pharmacology KW - Glutamic Acid -- metabolism KW - Brain-Derived Neurotrophic Factor -- pharmacology KW - Dopamine -- metabolism KW - Nerve Growth Factor -- pharmacology KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70259229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Effects+of+NGF+and+BDNF+on+baseline+glutamate+and+dopamine+release+in+the+hippocampal+formation+of+the+adult+rat.&rft.au=Paredes%2C+D%3BGranholm%2C+A-Ch%3BBickford%2C+P+C&rft.aulast=Paredes&rft.aufirst=D&rft.date=2007-04-13&rft.volume=1141&rft.issue=&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-01 N1 - Date created - 2007-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuropharmacology. 2002 Jun;42(7):903-12 [12069900] Exp Brain Res. 1993;93(2):226-30 [8491263] Brain Res. 2002 Nov 15;955(1-2):183-90 [12419535] Neurobiol Aging. 2003 Jan-Feb;24(1):37-48 [12493549] Invest Ophthalmol Vis Sci. 2003 Feb;44(2):791-8 [12556415] Brain Res. 2003 Apr 4;968(1):156-61 [12644273] Neuropharmacology. 2003 Mar;44(3):390-402 [12696558] Neuroscience. 2003;119(3):767-75 [12809697] J Biol Chem. 2003 Oct 17;278(42):41259-69 [12902347] Neuroreport. 1995 May 9;6(7):1063-6 [7632896] Exp Neurol. 1995 Nov;136(1):73-88 [7589336] Nature. 1999 Oct 28;401(6756):918-21 [10553907] Hippocampus. 1999;9(5):519-26 [10560922] Nat Neurosci. 2000 Apr;3(4):323-9 [10725920] J Neurophysiol. 2000 Jul;84(1):472-83 [10899220] Neuroreport. 2001 Aug 28;12(12):2673-7 [11522946] J Neurosci Res. 2001 Oct 1;66(1):96-108 [11599006] J Neurochem. 2001 Nov;79(3):522-30 [11701755] Neuron. 2001 Dec 6;32(5):767-70 [11738023] J Biol Chem. 2002 Feb 22;277(8):6520-9 [11741947] J Biochem. 2002 Jun;131(6):887-94 [12038986] J Comp Neurol. 1996 May 6;368(3):371-82 [8725345] J Biol Chem. 1996 Aug 30;271(35):21100-7 [8702878] Brain Res Mol Brain Res. 1996 Dec;42(2):317-27 [9013789] J Neurochem. 1997 Apr;68(4):1553-63 [9084426] Neurosci Lett. 1997 May 2;226(3):207-9 [9175603] J Pharmacol Exp Ther. 1997 Aug;282(2):760-8 [9262339] J Neurosci. 1997 Nov 1;17(21):8476-90 [9334420] Brain Pathol. 1998 Apr;8(2):253-61 [9546284] J Control Release. 1998 Apr 30;53(1-3):1-6 [9741908] Eur J Neurosci. 1998 Jun;10(6):2185-91 [9753104] Gen Pharmacol. 1998 Nov;31(5):667-74 [9809461] Microsc Res Tech. 1999 May 15-Jun 1;45(4-5):262-75 [10383119] Eur J Neurosci. 1999 Jul;11(7):2291-304 [10383618] Brain Res. 1999 Sep 25;842(2):431-8 [10526139] Brain Res Mol Brain Res. 2004 Nov 4;130(1-2):178-86 [15519688] Brain Res Brain Res Rev. 2004 Dec;47(1-3):126-44 [15572168] J Cell Biol. 2004 Dec 20;167(6):1205-15 [15596541] Exp Neurol. 2005 Nov;196(1):30-40 [16137678] Mol Cell Neurosci. 2006 Jan;31(1):70-84 [16214365] J Neurosci Res. 2006 Apr;83(5):832-44 [16477614] Neuron. 2004 May 27;42(4):522-4 [15157413] Neurobiol Aging. 2004 Aug;25(7):873-84 [15212841] Brain Res. 2004 Jul 30;1016(1):72-8 [15234254] Neuroscience. 2004;128(1):201-8 [15450367] J Neurosci Methods. 1985 Apr;13(2):139-43 [3889509] Life Sci. 1986 Dec 29;39(26):2629-37 [2432375] Neuron. 1990 Oct;5(4):501-9 [1688327] J Comp Neurol. 1990 Aug 22;298(4):443-57 [2172323] J Pharm Biomed Anal. 1990;8(5):419-29 [2081203] Brain Res. 1992 Apr 17;577(2):300-5 [1606501] Ann N Y Acad Sci. 1992 May 11;648:296-9 [1322082] J Chromatogr. 1992 Sep 11;608(1-2):189-95 [1430021] Eur J Neurosci. 2002 Oct;16(8):1449-62 [12405958] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reaching a Milestone in Diagnosing Coeliac Disease: Commentary AN - 57176311; 200711242 AB - Clinical prediction rules for diagnosis seek to optimise the sensitivity and specificity of our diagnostic approach to a given problem. In this issue of the BMJ, Hopper and colleagues report a rare accomplishment in this regard a decision rule that achieved 100% sensitivity in disease detection, in this case for coeliac disease. The rule is simple a positive serological test for IgA antibody to tissue transglutaminase combined with being at "high risk" (having weight loss, diarrhoea, or anaemia). The rule identified every patient with the disease in a cohort of 2000 patients, all of whom underwent intestinal biopsy as the gold standard and the final diagnostic step. This is a welcome advance. As the authors emphasise, coeliac disease may affect up to one in a 100 people, only one case in seven is ever diagnosed, and an appreciable diagnostic delay of many years often occurs. References. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Graber, Mark L AU - Kumar, Atul AD - VA Medical Center, Northport, NY, US mark.graber@med.va.gov Y1 - 2007/04/07/ PY - 2007 DA - 2007 Apr 07 SP - 732 EP - 733 PB - British Medical Association, BMJ Publishing Group, London UK VL - 334 IS - 7596 SN - 0959-535X, 0959-535X KW - Evaluation KW - Serological markers KW - Coeliac disease KW - Endoscopy KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57176311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Reaching+a+Milestone+in+Diagnosing+Coeliac+Disease%3A+Commentary&rft.au=Graber%2C+Mark+L%3BKumar%2C+Atul&rft.aulast=Graber&rft.aufirst=Mark&rft.date=2007-04-07&rft.volume=334&rft.issue=7596&rft.spage=732&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.39161.587720.BE LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-02 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Coeliac disease; Serological markers; Endoscopy; Evaluation DO - http://dx.doi.org/10.1136/bmj.39161.587720.BE ER - TY - JOUR T1 - Does This Adult Patient Have Septic Arthritis? AN - 19884336; 7406418 AB - CONTEXT: In patients who present with an acutely painful and swollen joint, prompt identification and treatment of septic arthritis can substantially reduce morbidity and mortality. OBJECTIVE: To review the accuracy and precision of the clinical evaluation for the diagnosis of nongonococcal bacterial arthritis. DATA SOURCES: Structured PubMed and EMBASE searches (1966 through January 2007), limited to human, English-language articles and using the following Medical Subject Headings terms: arthritis, infectious, physical examination, medical history taking, diagnostic tests, and sensitivity and specificity. STUDY SELECTION: Studies were included if they contained original data on the accuracy or precision of historical items, physical examination, serum, or synovial fluid laboratory data for diagnosing septic arthritis. DATA EXTRACTION: Three authors independently abstracted data from the included studies. DATA SYNTHESIS: Fourteen studies involving 6242 patients, of whom 653 met the gold standard for the diagnosis of septic arthritis, satisfied all inclusion criteria. Two studies examined risk factors and found that age, diabetes mellitus, rheumatoid arthritis, joint surgery, hip or knee prosthesis, skin infection, and human immunodeficiency virus type 1 infection significantly increase the probability of septic arthritis. Joint pain (sensitivity, 85%; 95% confidence interval [CI], 78%-90%), a history of joint swelling (sensitivity, 78%; 95% CI, 71%-85%), and fever (sensitivity, 57%; 95% CI, 52%-62%) are the only findings that occur in more than 50% of patients. Sweats (sensitivity, 27%; 95% CI, 20%-34%) and rigors (sensitivity, 19%; 95% CI, 15%-24%) are less common findings in septic arthritis. Of all laboratory findings readily available to the clinician, the 2 most powerful were the synovial fluid white blood cell (WBC) count and percentage of polymorphonuclear cells from arthrocentesis. The summary likelihood ratio (LR) increased as the synovial fluid WBC count increased (for counts 50 000/ mu L: LR, 7.7; 95% CI, 5.7-11.0; and for counts >100 000/ mu L: LR, 28.0; 95% CI, 12.0-66.0). On the same synovial fluid sample, a polymorphonuclear cell count of at least 90% suggests septic arthritis with an LR of 3.4 (95% CI, 2.8-4.2), while a polymorphonuclear cell count of less than 90% lowers the likelihood (LR, 0.34; 95% CI, 0.25-0.47). CONCLUSIONS: Clinical findings identify patients with peripheral, monoarticular arthritis who might have septic arthritis. However, the synovial WBC and percentage of polymorphonuclear cells from arthrocentesis are required to assess the likelihood of septic arthritis before the Gram stain and culture test results are known. JF - JAMA: Journal of the American Medical Association AU - Margaretten, Mary E AU - Kohlwes, Jeffrey AU - Moore, Dan AU - Bent, Stephen AD - Division of Rheumatology (Dr Margaretten), Prime Program, Department of Medicine, University of California, San Francisco, and Department of Medicine, San Francisco Veterans Administration Medical Center (Drs Kohlwes and Bent), and Department of Epidemiology and Biostatistics, University of California, San Francisco (Dr Moore) Y1 - 2007/04/04/ PY - 2007 DA - 2007 Apr 04 SP - 1478 EP - 1488 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 297 IS - 13 SN - 0098-7484, 0098-7484 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Mortality KW - Age KW - Data processing KW - Skin KW - Sweat KW - Leukocytes (polymorphonuclear) KW - Leukocytes KW - Joint diseases KW - Cell culture KW - Pain KW - Infection KW - Knee KW - Morbidity KW - Fever KW - Diabetes mellitus KW - Rheumatoid arthritis KW - Synovial fluid KW - Gram stain KW - Risk factors KW - Surgery KW - Human immunodeficiency virus 1 KW - Hip KW - V 22360:AIDS and HIV KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19884336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Does+This+Adult+Patient+Have+Septic+Arthritis%3F&rft.au=Margaretten%2C+Mary+E%3BKohlwes%2C+Jeffrey%3BMoore%2C+Dan%3BBent%2C+Stephen&rft.aulast=Margaretten&rft.aufirst=Mary&rft.date=2007-04-04&rft.volume=297&rft.issue=13&rft.spage=1478&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Skin; Data processing; Leukocytes (polymorphonuclear); Sweat; Leukocytes; Joint diseases; Pain; Cell culture; Infection; Morbidity; Knee; Diabetes mellitus; Fever; Rheumatoid arthritis; Synovial fluid; Gram stain; Surgery; Risk factors; Hip; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Antidepressant therapy in tinnitus. AN - 85397416; pmid-16973315 AB - OBJECTIVE: Review the literature on the co-morbidity of depression and anxiety with tinnitus. Briefly consider proposed mechanisms by which antidepressants might be helpful for tinnitus, including treatment of co-morbid depression and anxiety and a more direct serotonergic mechanism of tinnitus. Survey the literature on antidepressants and tinnitus including tinnitus reported as a side effect of antidepressants (phenelzine, amitriptyline, protriptyline, doxepin, imipramine, fluoxetine, trazadone, bupropion, venlafaxine), tinnitus associated with withdrawal of antidepressants (venlafaxine and sertraline) and antidepressants as a treatment for tinnitus (case reports--fluoxetine and paroxetine, retrospective reviews--imipramine and selective serotonin reuptake inhibitors, single blind trials of amitriptyline and double blind placebo controlled trials of trimipramine, nortriptyline, paroxetine and sertraline). Provide suggestions on future directions, specifically replication of prior studies and a dose finding study of paroxetine for the treatment of tinnitus. JF - Hearing research AU - Robinson, Shannon K AU - Viirre, Erik S AU - Stein, Murray B AD - Department of Psychiatry, University of California, San Diego School of Medicine, Veterans Administration San Diego Healthcare System, 3350 La Jolla Village Dr., Mail Code 116A, La Jolla, CA 92161, USA. skrobinson@ucsd.edu Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 221 EP - 231 VL - 226 IS - 1-2 SN - 0378-5955, 0378-5955 KW - Index Medicus KW - National Library of Medicine KW - Antidepressive Agents: adverse effects KW - *Antidepressive Agents: therapeutic use KW - Anxiety: complications KW - Anxiety: drug therapy KW - Clinical Trials as Topic KW - Depression: complications KW - Depression: drug therapy KW - Humans KW - Substance Withdrawal Syndrome: etiology KW - Tinnitus: chemically induced KW - Tinnitus: complications KW - *Tinnitus: drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85397416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+research&rft.atitle=Antidepressant+therapy+in+tinnitus.&rft.au=Robinson%2C+Shannon+K%3BViirre%2C+Erik+S%3BStein%2C+Murray+B&rft.aulast=Robinson&rft.aufirst=Shannon&rft.date=2007-04-01&rft.volume=226&rft.issue=1-2&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Hearing+research&rft.issn=03785955&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Subjective measures of hearing aid benefit and satisfaction in the NIDCD/VA follow-up study. AN - 85397027; pmid-17580727 AB - Perceived benefit, satisfaction, and hearing aid use patterns were measured in a follow-up study to a large-scale multi-site clinical trial conducted in 1996-97. Measures included the Hearing Aid Status Questionnaire, the Profile of Hearing Aid Benefit, the Glasgow Hearing Aid Benefit Profile, the Satisfaction with Amplification in Daily Life, and the International Outcome Inventory for Hearing Aids. On the Profile of Hearing Aid Benefit, hearing aid users indicated more unaided difficulty in easy listening situations and less aided benefit in more difficult listening situations compared to the original study. Subjects who no longer used hearing aids indicated less difficulty in unaided situations. All measures indicated significant long-term subjective benefit and satisfaction with hearing aids. Although understanding speech in noise or in group situations continues to be problematic, subjects reported wearing their hearing aids almost all of the time in both easy and difficult listening situations. JF - Journal of the American Academy of Audiology AU - Takahashi, Gail AU - Martinez, Charles D AU - Beamer, Sharon AU - Bridges, Julie AU - Noffsinger, Douglas AU - Sugiura, Karen AU - Bratt, Gene W AU - Williams, David W AD - Audiology and Speech Pathology Service, VA Medical Center, 601 Highway 6 West, Iowa City, IA 52246, USA. gail.takahashi@va.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 323 EP - 349 VL - 18 IS - 4 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - Audiometry KW - Female KW - Follow-Up Studies KW - *Hearing Aids KW - *Hearing Loss, Sensorineural: rehabilitation KW - Humans KW - Male KW - Middle Aged KW - *Patient Satisfaction KW - Questionnaires KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85397027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Subjective+measures+of+hearing+aid+benefit+and+satisfaction+in+the+NIDCD%2FVA+follow-up+study.&rft.au=Takahashi%2C+Gail%3BMartinez%2C+Charles+D%3BBeamer%2C+Sharon%3BBridges%2C+Julie%3BNoffsinger%2C+Douglas%3BSugiura%2C+Karen%3BBratt%2C+Gene+W%3BWilliams%2C+David+W&rft.aulast=Takahashi&rft.aufirst=Gail&rft.date=2007-04-01&rft.volume=18&rft.issue=4&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - NIDCD/VA hearing aid clinical trial and follow-up: background. AN - 85396988; pmid-17580723 AB - This report provides background regarding the Long Term Follow-Up of Patients in the NIDCD/VA Hearing Aid Clinical Trial study and serves as an introduction to the detailed reports that follow in this issue of Journal of the American Academy of Audiology. The authors investigated five- to seven-year benefit/satisfaction in participants from the original NIDCDNA Hearing Aid Clinical Trial. The new study was designed to investigate current use of the original study hearing aids, to compare changes in selected audiological measures, and to assess possible predictors of long-term hearing aid use. The outcome measures included estimates of speech intelligibility in quiet and noise, self-reported patterns of hearing aid usage, self-reported estimates of activity limitations and quality-of-life issues, estimates of hearing aid satisfaction, and self-reported hearing aid benefit. Overall, the short-term benefits of hearing aid use observed during the original trial were noted to persist in the long term. JF - Journal of the American Academy of Audiology AU - Bratt, Gene W AU - Rosenfeld, Mia A L AU - Williams, David W AD - VA Tennessee Valley Healthcare System, Vanderbilt Bill Wilkerson Center, Vanderbilt University, Nashville, TN 37212, USA. gene.bratt@med.va.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 274 EP - 281 VL - 18 IS - 4 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - *Clinical Trials as Topic KW - *Follow-Up Studies KW - *Hearing Aids KW - *Hearing Loss, Sensorineural: rehabilitation KW - Humans KW - *Research Design KW - United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=NIDCD%2FVA+hearing+aid+clinical+trial+and+follow-up%3A+background.&rft.au=Bratt%2C+Gene+W%3BRosenfeld%2C+Mia+A+L%3BWilliams%2C+David+W&rft.aulast=Bratt&rft.aufirst=Gene&rft.date=2007-04-01&rft.volume=18&rft.issue=4&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - NIDCD/VA hearing aid clinical trial and follow-up: coupler and real-ear measurement. AN - 85394632; pmid-17580724 AB - A total of 190 individuals participated in a clinical visit during the Cooperative Studies Program (CSP) 418-A Long Term Follow-Up Study. Of this cohort, 158 participants were considered current hearing aid users, and 32 were non-hearing aid users. Of the current hearing aid users, 81 were still using their original 418 study devices, and 77 had acquired new hearing aids. Coupler and real ear measurements were completed on all available hearing aids. Results showed that study aids had remained relatively stable over the six years between CSP 418 and CSP 418-A. On average, these hearing aid wearers preferred use gain settings that were 6-9 dB less than current NAL-RP insertion gain targets. Mean real ear insertion gain (REIG) was comparable to the mean real ear insertion gain of the same participants in the original study, and users did not tend to increase gain as hearing decreased. Real ear saturation responses (RESR) remained unchanged. Loudness discomfort levels (LDL) obtained during 418-A were significantly lower than LDLs obtained on those same participants at both the initial and final visits in the previous study. JF - Journal of the American Academy of Audiology AU - Peek, Barbara F AU - Rosenfeld, Mia A L AU - Bratt, Gene W AU - Williams, David W AD - VA Tennessee Valley Healthcare System Nashville, TN 37217, USA. barbara.peek@va.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 282 EP - 291 VL - 18 IS - 4 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Equipment Failure Analysis KW - Follow-Up Studies KW - *Hearing Aids KW - *Hearing Loss, Sensorineural: rehabilitation KW - Humans KW - Loudness Perception KW - Prosthesis Fitting KW - Time Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85394632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=NIDCD%2FVA+hearing+aid+clinical+trial+and+follow-up%3A+coupler+and+real-ear+measurement.&rft.au=Peek%2C+Barbara+F%3BRosenfeld%2C+Mia+A+L%3BBratt%2C+Gene+W%3BWilliams%2C+David+W&rft.aulast=Peek&rft.aufirst=Barbara&rft.date=2007-04-01&rft.volume=18&rft.issue=4&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Speech-recognition performance after long-term hearing aid use. AN - 85393600; pmid-17580725 AB - Larson et al (2000) reported the findings of a multicenter, NIDCDNA clinical trial that compared hearing aid performance for three output limiting circuits in 360 adults with symmetrical sensorineural hearing loss. The current study was undertaken to examine long-term hearing aid benefit in this same group of participants following five to six years of hearing aid use. The speech-recognition portion of the follow-up study enrolled 108 participants from the original study, 85% of whom were current hearing aid users and 15% of whom had not worn hearing aids during the past month (nonusers). Recognition performance in sound field on the NU-6 (quiet at 62 dB SPL) and the CST (quiet at 74 dB SPL and with -3 and 3 dB signal-to-babble ratios [S/B] at 62 and 74 dB SPL) was measured unaided and aided whenever possible. Speech-recognition abilities decreased significantly since the original study. Speech-recognition decrements were observed regardless of the speech materials (NU-6 and CST), test condition (quiet and noise), S/B (-3 and 3 dB), or stimulus level (62 and 74 dB SPL). Despite decreases in speech recognition, hearing aid benefit remained largely unchanged since the original study; aided performance exceeded unaided performance regardless of presentation level or noise condition. As in the original study, the relations among stimulus level, S/B, and speech-recognition performance were complex. JF - Journal of the American Academy of Audiology AU - Shanks, Janet E AU - Wilson, Richard H AU - Stelmachowicz, Patricia AU - Bratt, Gene W AU - Williams, David W AD - Janet E. Shanks, Ph.D., Audiology 126, VA Long Beach Healthcare System, 5901 E. Seventh Street, Long Beach, CA 90822, USA. janet.shanks@va.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 292 EP - 303 VL - 18 IS - 4 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Audiometry, Pure-Tone KW - Audiometry, Speech KW - Follow-Up Studies KW - *Hearing Aids KW - *Hearing Loss, Sensorineural: physiopathology KW - *Hearing Loss, Sensorineural: rehabilitation KW - Humans KW - Patient Compliance KW - *Speech Perception: physiology KW - Time Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85393600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Speech-recognition+performance+after+long-term+hearing+aid+use.&rft.au=Shanks%2C+Janet+E%3BWilson%2C+Richard+H%3BStelmachowicz%2C+Patricia%3BBratt%2C+Gene+W%3BWilliams%2C+David+W&rft.aulast=Shanks&rft.aufirst=Janet&rft.date=2007-04-01&rft.volume=18&rft.issue=4&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - SSRIs & the risk of abnormal bleeding. AN - 70468551; 17477325 AB - Considerable research is needed to fully understand the interactions of SSRIs and hematological functioning. Adequate studies of platelet function in patients taking SSRIs are lacking. The risk of bleeding with SSRI treatment appears to be low, and the occurrence of bleeding is usually minor when it does occur. However, the risk does exist and must be considered in any patient taking SSRIs who develops abnormal bleeding or bruising not otherwise explained by an appropriate assessment to determine the etiology. Routine monitoring of patients taking SSRIs should probably include questions about bruising or bleeding, particularly in patients with blood dyscrasias and in older patients taking medications that affect platelet function. Caution should be exercised before starting patients with preexisting bleeding risks on SSRIs, including patients taking NSAIDs, aspirin, or other drugs that may impair coagulation. JF - Journal of psychosocial nursing and mental health services AU - Reeves, Roy R AU - Wise, P Melonee AU - Cox, Sera K AD - Montgomery VA Medical Center, Jackson, MS 39216, USA. roy.reeves@med.va.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 15 EP - 21 VL - 45 IS - 4 SN - 0279-3695, 0279-3695 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Fibrinolytic Agents KW - Serotonin Uptake Inhibitors KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Nursing KW - Evidence-Based Medicine KW - Humans KW - Retrospective Studies KW - Fibrinolytic Agents -- adverse effects KW - Research Design KW - Risk Assessment KW - Population Surveillance KW - Nursing Assessment KW - Aspirin -- adverse effects KW - Risk Factors KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Cohort Studies KW - Drug Monitoring KW - Case-Control Studies KW - Databases, Factual KW - Drug Synergism KW - Hemorrhage -- epidemiology KW - Hemorrhage -- chemically induced KW - Hemorrhage -- prevention & control KW - Serotonin Uptake Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70468551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychosocial+nursing+and+mental+health+services&rft.atitle=SSRIs+%26amp%3B+the+risk+of+abnormal+bleeding.&rft.au=Reeves%2C+Roy+R%3BWise%2C+P+Melonee%3BCox%2C+Sera+K&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2007-04-01&rft.volume=45&rft.issue=4&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychosocial+nursing+and+mental+health+services&rft.issn=02793695&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-31 N1 - Date created - 2007-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sunitinib induces hypothyroidism in advanced cancer patients and may inhibit thyroid peroxidase activity. AN - 70450147; 17465866 AB - Sunitinib is a novel tyrosine kinase inhibitor with antitumor and antiangiogenic effects. An observed higher than expected rate of hypothyroidism in sunitinib-treated patients prompted assessment of the incidence of hypothyroidism. Patients taking sunitinib had their thyroid function tests (TFTs) assessed via chart review. To explore potential effects on the thyroid, we examined the antiperoxidase activity of sunitinib by in vitro testing its effect on guaiacol oxidation and protein iodination by lactoperoxidase. Of the 89 patients who took sunitinib, 49 patients were excluded from analysis for several reasons. Of the remaining 40 patients, 21 (53%, 24% of the original 89) developed elevated thyrotropin (TSH) after a median of 5 months (range 1-36 months). Median TSH was 21.4 mU/L (range 4.6-174 mU/L). In vitro, sunitinib had antiperoxidase activity that was about one-fourth the potency of propylthiouracil. Of the 40 patients who had TFTs assessed after starting sunitinib, 53% developed elevated TSH. We recommend that all patients treated with sunitinib be monitored for hypothyroidism. The mechanism of the antithyroid effect appears to be inhibition of peroxidase activity. Further research is needed to confirm the mechanism by which sunitinib induces hypothyroidism. JF - Thyroid : official journal of the American Thyroid Association AU - Wong, Elaine AU - Rosen, Lee S AU - Mulay, Marilyn AU - Vanvugt, Andy AU - Dinolfo, Melissa AU - Tomoda, Chisato AU - Sugawara, Masahiro AU - Hershman, Jerome M AD - Endocrinology and Diabetes Division, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 351 EP - 355 VL - 17 IS - 4 SN - 1050-7256, 1050-7256 KW - Indoles KW - 0 KW - Pyrroles KW - Iodide Peroxidase KW - EC 1.11.1.8 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - sunitinib KW - V99T50803M KW - Index Medicus KW - Protein-Tyrosine Kinases -- antagonists & inhibitors KW - Humans KW - Gastrointestinal Stromal Tumors -- drug therapy KW - Thyroid Function Tests KW - Retrospective Studies KW - Pyrroles -- adverse effects KW - Indoles -- adverse effects KW - Iodide Peroxidase -- antagonists & inhibitors KW - Hypothyroidism -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70450147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thyroid+%3A+official+journal+of+the+American+Thyroid+Association&rft.atitle=Sunitinib+induces+hypothyroidism+in+advanced+cancer+patients+and+may+inhibit+thyroid+peroxidase+activity.&rft.au=Wong%2C+Elaine%3BRosen%2C+Lee+S%3BMulay%2C+Marilyn%3BVanvugt%2C+Andy%3BDinolfo%2C+Melissa%3BTomoda%2C+Chisato%3BSugawara%2C+Masahiro%3BHershman%2C+Jerome+M&rft.aulast=Wong&rft.aufirst=Elaine&rft.date=2007-04-01&rft.volume=17&rft.issue=4&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Thyroid+%3A+official+journal+of+the+American+Thyroid+Association&rft.issn=10507256&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-26 N1 - Date created - 2007-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Thyroid. 2008 Jul;18(7):809-12 [18631016] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diabetes and depression: pharmacologic considerations. AN - 70307927; 17388852 JF - Perspectives in psychiatric care AU - Antai-Otong, Deborah AD - deborah.antai-otong@va.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 93 EP - 96 VL - 43 IS - 2 SN - 0031-5990, 0031-5990 KW - Antidepressive Agents KW - 0 KW - Nursing KW - Nursing Diagnosis KW - Cooperative Behavior KW - Humans KW - Nurse Practitioners KW - Primary Health Care KW - Comorbidity KW - Depressive Disorder, Major -- diagnosis KW - Depressive Disorder, Major -- drug therapy KW - Diabetes Mellitus, Type 2 -- nursing KW - Diabetes Mellitus, Type 2 -- epidemiology KW - Diabetes Mellitus, Type 2 -- psychology KW - Antidepressive Agents -- therapeutic use KW - Depressive Disorder, Major -- epidemiology KW - Antidepressive Agents -- adverse effects KW - Depressive Disorder, Major -- nursing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70307927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+psychiatric+care&rft.atitle=Diabetes+and+depression%3A+pharmacologic+considerations.&rft.au=Antai-Otong%2C+Deborah&rft.aulast=Antai-Otong&rft.aufirst=Deborah&rft.date=2007-04-01&rft.volume=43&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+psychiatric+care&rft.issn=00315990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-14 N1 - Date created - 2007-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Strategies for achieving transfusion independence in myelodysplastic syndromes. AN - 70300102; 16935559 AB - Myelodysplastic syndromes (MDS) are a group of complex diseases of the myeloid stem cell that result in chronic cytopenias. In some instances, these disorders may progress to acute myeloid leukemia. Patients with MDS frequently experience chronic, symptomatic anemia, and many become dependent on chronic transfusions of packed red blood cells. However, long-term transfusion dependence has clinical and economic consequences, including a potentially negative impact on patients' quality of life (QOL). Recently, studies have investigated various strategies to reduce or eliminate transfusion needs in MDS patients. Supportive measures with hematopoietic growth factors such as erythropoietin are often less effective in MDS-associated anemia than in anemia from other causes, but some patients may benefit from this approach. Treatment with other agents, such as antithymocyte globulin, azacitidine, decitabine, thalidomide, and lenalidomide, has resulted in transfusion independence in some subsets of MDS patients. Nurses who care for patients with MDS should be aware of the impact of transfusion dependence on the patient's QOL, as well as the benefits and risks of the various other treatment options available to these patients. Such knowledge will enable the nurse to provide accurate, relevant information, so that patients can make informed choices regarding treatment options for MDS. JF - European journal of oncology nursing : the official journal of European Oncology Nursing Society AU - Thomas, Mary Laudon AD - VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA. mary.thomas4@va.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 151 EP - 158 VL - 11 IS - 2 SN - 1462-3889, 1462-3889 KW - Antilymphocyte Serum KW - 0 KW - Antimetabolites, Antineoplastic KW - Immunosuppressive Agents KW - Erythropoietin KW - 11096-26-7 KW - Thalidomide KW - 4Z8R6ORS6L KW - decitabine KW - 776B62CQ27 KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Nursing KW - Health Services Needs and Demand KW - Azacitidine -- therapeutic use KW - Azacitidine -- analogs & derivatives KW - Humans KW - Erythropoietin -- therapeutic use KW - Quality of Life KW - Patient Selection KW - Antilymphocyte Serum -- therapeutic use KW - Drug Costs KW - Patient Education as Topic KW - Oncology Nursing -- organization & administration KW - Treatment Outcome KW - Nurse's Role KW - Informed Consent KW - Thalidomide -- therapeutic use KW - Anemia -- etiology KW - Anemia -- therapy KW - Myelodysplastic Syndromes -- therapy KW - Myelodysplastic Syndromes -- psychology KW - Erythrocyte Transfusion -- economics KW - Erythrocyte Transfusion -- adverse effects KW - Antimetabolites, Antineoplastic -- economics KW - Myelodysplastic Syndromes -- complications KW - Immunosuppressive Agents -- economics KW - Immunosuppressive Agents -- therapeutic use KW - Antimetabolites, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70300102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+oncology+nursing+%3A+the+official+journal+of+European+Oncology+Nursing+Society&rft.atitle=Strategies+for+achieving+transfusion+independence+in+myelodysplastic+syndromes.&rft.au=Thomas%2C+Mary+Laudon&rft.aulast=Thomas&rft.aufirst=Mary&rft.date=2007-04-01&rft.volume=11&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=European+journal+of+oncology+nursing+%3A+the+official+journal+of+European+Oncology+Nursing+Society&rft.issn=14623889&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-29 N1 - Date created - 2007-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II. AN - 70299577; 17272743 AB - Human endothelial cells use the multidrug resistance protein-1 (MRP1) to export glutathione disulfide (GSSG). This can promotes thiol loss during states of increased glutathione oxidation. We investigated how MRP1 modulates blood pressure and vascular function during angiotensin II-induced hypertension. Angiotensin II-induced hypertension altered vascular glutathione flux by increasing GSSG export and decreasing vascular levels of glutathione in wild-type (FVB) but not in MRP1-/- mice. Aortic endothelium-dependent vasodilatation was reduced in FVB after angiotensin II infusion, but unchanged in MRP1-/- mice. Aortic superoxide (O2*-) production and expression of several NADPH oxidase subunits were increased by angiotensin II in FVB. These effects were markedly blunted in MRP1-/- vessels. The increase in O2*- production in FVB vessels caused by angiotensin II was largely inhibited by L-NAME, suggesting eNOS uncoupling. Accordingly, aortic tetrahydrobiopterin and levels of NO were decreased by angiotensin II in FVB but were unchanged in MRP1-/-. Finally, the hypertension caused by angiotensin II was markedly blunted in MRP1-/- mice (137+/-4 versus 158+/-6 mm Hg). MRP1 plays a crucial role in the genesis of multiple vascular abnormalities that accompany hypertension and its presence is essential for the hypertensive response to angiotensin II. JF - Arteriosclerosis, thrombosis, and vascular biology AU - Widder, Julian D AU - Guzik, Tomasz J AU - Mueller, Cornelius F H AU - Clempus, Roza E AU - Schmidt, Harald H H W AU - Dikalov, Sergey I AU - Griendling, Kathy K AU - Jones, Dean P AU - Harrison, David G AD - Emory University, Division of Cardiology, Department of Medicine and the Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 762 EP - 768 VL - 27 IS - 4 KW - Enzyme Inhibitors KW - 0 KW - Isoenzymes KW - P-Glycoprotein KW - Superoxides KW - 11062-77-4 KW - Angiotensin II KW - 11128-99-7 KW - Biopterin KW - 22150-76-1 KW - Nitric Oxide KW - 31C4KY9ESH KW - NADPH Oxidase KW - EC 1.6.3.1 KW - sapropterin KW - EGX657432I KW - Glutathione Disulfide KW - ULW86O013H KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Index Medicus KW - NADPH Oxidase -- metabolism KW - Animals KW - NG-Nitroarginine Methyl Ester -- pharmacology KW - Nitric Oxide -- antagonists & inhibitors KW - Blood Pressure KW - Glutathione Disulfide -- metabolism KW - Nitric Oxide -- metabolism KW - Mice KW - Endothelium, Vascular -- physiopathology KW - Isoenzymes -- metabolism KW - Mice, Knockout KW - Biopterin -- analogs & derivatives KW - Mice, Inbred Strains KW - Superoxides -- metabolism KW - Vasodilation KW - Enzyme Inhibitors -- pharmacology KW - Biopterin -- metabolism KW - Male KW - Aorta -- metabolism KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology KW - P-Glycoprotein -- metabolism KW - Aorta -- physiopathology KW - P-Glycoprotein -- deficiency KW - Angiotensin II -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70299577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.atitle=Role+of+the+multidrug+resistance+protein-1+in+hypertension+and+vascular+dysfunction+caused+by+angiotensin+II.&rft.au=Widder%2C+Julian+D%3BGuzik%2C+Tomasz+J%3BMueller%2C+Cornelius+F+H%3BClempus%2C+Roza+E%3BSchmidt%2C+Harald+H+H+W%3BDikalov%2C+Sergey+I%3BGriendling%2C+Kathy+K%3BJones%2C+Dean+P%3BHarrison%2C+David+G&rft.aulast=Widder&rft.aufirst=Julian&rft.date=2007-04-01&rft.volume=27&rft.issue=4&rft.spage=762&rft.isbn=&rft.btitle=&rft.title=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.issn=1524-4636&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-25 N1 - Date created - 2007-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predictors of a suicide attempt one year after entry into substance use disorder treatment. AN - 70292440; 17374043 AB - The present study examined the patient intake and treatment-related risk factors associated with a suicide attempt in the 30 days before a 1-year posttreatment assessment. A national sample of 8,807 patients presenting for treatment of substance use disorders (SUDs) in the Department of Veterans Affairs healthcare system were assessed at treatment intake and follow-up. Using the MacArthur Model, the risk and protective factors for suicide attempt were identified at baseline and during treatment. At follow-up, 4% (314/8,807) of the patients reported a suicide attempt within the past 30 days. Baseline predictors of a suicide attempt before follow-up included elevated suicidal/psychiatric symptoms, more recent problematic alcohol use, and longer duration of cocaine use. Contact with the criminal justice system was a protective factor that reduced the likelihood of a future suicide attempt. Greater engagement in SUD treatment was also associated with a reduction in suicide risk. More involvement in SUD treatment reduced the likelihood of a future suicide attempt in high-risk patients. Substance use disorder treatment providers interested in reducing future suicidal behavior may want to concentrate their efforts on identifying at-risk individuals and actively engaging these patients in longer treatment episodes. JF - Alcoholism, clinical and experimental research AU - Ilgen, Mark A AU - Harris, Alex H S AU - Moos, Rudolf H AU - Tiet, Quyen Q AD - Department of Veterans Affairs, Center for Health Care Evaluation, Palo Alto Health Care System and Stanford University School of Medicine, Menlo Park, California 94025, USA. mark.ilgen@va.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 635 EP - 642 VL - 31 IS - 4 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - United States KW - Crime KW - Mental Disorders -- epidemiology KW - Humans KW - Cocaine-Related Disorders -- psychology KW - Models, Statistical KW - Mental Disorders -- psychology KW - Employment KW - Longitudinal Studies KW - Alcoholism -- psychology KW - Cocaine-Related Disorders -- complications KW - Risk Assessment KW - Substance Abuse Treatment Centers KW - United States Department of Veterans Affairs KW - Risk Factors KW - Adult KW - Databases, Factual KW - Middle Aged KW - Follow-Up Studies KW - Forecasting KW - Alcoholism -- complications KW - Male KW - Female KW - Suicide, Attempted -- statistics & numerical data KW - Suicide, Attempted -- psychology KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70292440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Predictors+of+a+suicide+attempt+one+year+after+entry+into+substance+use+disorder+treatment.&rft.au=Ilgen%2C+Mark+A%3BHarris%2C+Alex+H+S%3BMoos%2C+Rudolf+H%3BTiet%2C+Quyen+Q&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2007-04-01&rft.volume=31&rft.issue=4&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2007-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of Performance on the CERAD Neuropsychological Battery of Hispanic Patients and Cognitively Normal Controls at Two Sites AN - 57290371; 200914624 AB - Based on 88 non-demented controls and 140 AD patients enrolled at the University of Southern California, and 102 Spanish-speaking dementia patients at the University of Pennsylvania, we developed norms, stratified by disease severity, for the Spanish-language CERAD Neuropsychological Battery, and examined the impact of demographic characteristics. Adequacy of information and level of performance differed between sites, indicating hazards that occur in the absence of cross-site planning, including characteristics of 'retrofitted' data (e.g., missing information), small samples, additional countries of origin, and multiple dementing disorders. Nevertheless, controls generally performed better than even very mild AD patients, and performance decreased with increase in severity of disease. In the absence of larger, more representative samples, norms for Spanish-speaking patients and control subjects may be site-specific, and should be treated with caution. Adapted from the source document. JF - Clinical Gerontologist AU - Fillenbaum, Gerda G AU - Kuchibhatla, Maragatha AU - Henderson, Victor W AU - Clark, Christopher M AU - Taussig, I Maribel AD - Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Durham, NC, USA Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 1 EP - 22 PB - Haworth Press/Taylor & Francis, Philadelphia PA VL - 30 IS - 3 SN - 0731-7115, 0731-7115 KW - Missing information KW - Severity KW - Hispanic people KW - Dementia KW - Demographic aspects KW - Control KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57290371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Gerontologist&rft.atitle=Comparison+of+Performance+on+the+CERAD+Neuropsychological+Battery+of+Hispanic+Patients+and+Cognitively+Normal+Controls+at+Two+Sites&rft.au=Fillenbaum%2C+Gerda+G%3BKuchibhatla%2C+Maragatha%3BHenderson%2C+Victor+W%3BClark%2C+Christopher+M%3BTaussig%2C+I+Maribel&rft.aulast=Fillenbaum&rft.aufirst=Gerda&rft.date=2007-04-01&rft.volume=30&rft.issue=3&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Clinical+Gerontologist&rft.issn=07317115&rft_id=info:doi/10.1300%2FJ018v30n03_01 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - CODEN - CLGEDA N1 - SubjectsTermNotLitGenreText - Control; Severity; Dementia; Demographic aspects; Hispanic people; Missing information DO - http://dx.doi.org/10.1300/J018v30n03_01 ER - TY - JOUR T1 - A Case of Addiction? You be the Judge AN - 57278916; 200904838 AB - Campaigns abound from every angle to make the management of pain a priority. State licensing boards continue to develop policies that support appropriate opiate prescribing rather than policies that hinder their use. The Veterans Administration has incorporated "Pain, The Fifth Vital Sign" into each patient assessment, ensuring adequate pain evaluation, & Joint Commission on Accreditation of Health Organization (JCAHO) has made the adequate treatment of pain a patient right. Adapted from the source document. JF - Journal of Addictions Nursing AU - Schmidt, Sharon Nighorn AU - Cobb, P Bradford AD - Psychiatric Nurse Practitioner, Psychiatry Service, Veterans Administration Southern Oregon Rehabilitation Centers and Clinics, White City, Oregon, USA Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 109 EP - 110 PB - Informa Healthcare, Taylor & Francis, New York NY VL - 18 IS - 2 SN - 1088-4602, 1088-4602 KW - Patient satisfaction KW - Disease management KW - Pain KW - Addiction KW - Treatment KW - Drugs KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57278916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Addictions+Nursing&rft.atitle=A+Case+of+Addiction%3F+You+be+the+Judge&rft.au=Schmidt%2C+Sharon+Nighorn%3BCobb%2C+P+Bradford&rft.aulast=Schmidt&rft.aufirst=Sharon&rft.date=2007-04-01&rft.volume=18&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Journal+of+Addictions+Nursing&rft.issn=10884602&rft_id=info:doi/10.1080%2F10884600701429448 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Pain; Drugs; Patient satisfaction; Disease management; Treatment; Addiction DO - http://dx.doi.org/10.1080/10884600701429448 ER - TY - JOUR T1 - Estimating the impact of alcohol consumption on survival for HIV + individuals AN - 36753284; 3470902 AB - Alcohol consumption is associated with decreased antiretroviral adherence, and decreased adherence results in poorer outcomes. However the magnitude of alcohol's impact on survival is unknown. Our objective was to use a calibrated and validated simulation of HIV disease to estimate the impact of alcohol on survival. We incorporated clinical data describing the temporal and dose-response relationships between alcohol consumption and adherence in a large observational cohort (N = 2,702). Individuals were categorized as nondrinkers (no alcohol consumption), hazardous drinkers (consume =>5 standard drinks on drinking days), and nonhazardous drinkers (consume <5 standard drinks on drinking days). Our results showed that nonhazardous alcohol consumption decreased survival by more than 1 year if the frequency of consumption was once per week or greater, and by 3.3 years (from 21.7 years to 18.4 years) with daily consumption. Hazardous alcohol consumption decreased overall survival by more than 3 years if frequency of consumption was once per week or greater, and by 6.4 years (from 16.1 years to 9.7 years) with daily consumption. Our results suggest that alcohol is an underappreciated yet modifiable risk factor for poor survival among individuals with HIV. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Braithwaite, R S AU - Conigliaro, J AU - Roberts, M S AU - Shechter, S AU - Schaefer, A AU - McGinnis, K AU - Rodriguez, M C AU - Rabeneck, L AU - Bryant, K AU - Justice, A C AD - Yale University ; University of Pittsburgh ; Houston Veterans Administration Medical Center ; University of Toronto ; National Institutes of Health, Bethesda Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 459 EP - 466 VL - 19 IS - 4 SN - 0954-0121, 0954-0121 KW - Sociology KW - Risk KW - Alcohol KW - Drinks KW - Consumption KW - Cross-sectional analysis KW - Diseases KW - Data analysis KW - HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36753284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Estimating+the+impact+of+alcohol+consumption+on+survival+for+HIV+%2B+individuals&rft.au=Braithwaite%2C+R+S%3BConigliaro%2C+J%3BRoberts%2C+M+S%3BShechter%2C+S%3BSchaefer%2C+A%3BMcGinnis%2C+K%3BRodriguez%2C+M+C%3BRabeneck%2C+L%3BBryant%2C+K%3BJustice%2C+A+C&rft.aulast=Braithwaite&rft.aufirst=R&rft.date=2007-04-01&rft.volume=19&rft.issue=4&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120601095734 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 909; 2805 3872 554 971; 5703 3617 6220; 3617 6220; 11035; 3063 971; 3279 971 3286; 3737 DO - http://dx.doi.org/10.1080/09540120601095734 ER - TY - JOUR T1 - A kinematic analysis of the rapid step test in balance-impaired and unimpaired older women AN - 20978271; 8567362 AB - Little is known about the kinematic and kinetic determinants that might explain age and balance-impairment alterations in the results of volitional stepping performance tests. Maximal unipedal stance time (UST) was used to distinguish "balance-impaired" old (BI, UST 30 s, N = 12, mean age = 71 years) before they and healthy young females (Y, UST > 30 s, N = 13, mean age = 23 years) performed the rapid step test (RST). The RST evaluates the time required to take volitional front, side, and back steps of at least 80% maximum step length in response to verbal commands. Kinematic and kinetic data were recorded during the RST. The results indicate that the initiation phase of the step was the major source of age- and balance impairment-related delays. The delays in BI were primarily caused by increased postural adjustments prior to step initiation, as measured by center-of-pressure (COP) path length (p < 0.003). The Step landing phase showed similar, but non- significant, temporal trends. Step length and peak center-of-mass (COM) deceleration during the Step-Out landing decreased in O by 18% (p = 0.0002) and 24% (p = 0.001), respectively, and a further 12% (p = 0.04) and 18% (p = 0.08) in BI. We conclude that the delay in BI step initiation was due to the increase in their postural adjustments prior to step initiation. JF - Gait & Posture AU - Schulz, Brian W AU - Ashton-Miller, James A AU - Alexander, Neil B AD - Department of Biomedical Engineering Biomechanics Research Laboratory, USA, Brian.Schulz@va.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 515 EP - 522 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 25 IS - 4 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Kinematics KW - Stepping KW - Landing KW - Step tests KW - Kinetics KW - Women KW - Performance KW - Posture KW - Balance KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20978271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=A+kinematic+analysis+of+the+rapid+step+test+in+balance-impaired+and+unimpaired+older+women&rft.au=Schulz%2C+Brian+W%3BAshton-Miller%2C+James+A%3BAlexander%2C+Neil+B&rft.aulast=Schulz&rft.aufirst=Brian&rft.date=2007-04-01&rft.volume=25&rft.issue=4&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2006.06.001 LA - English DB - Physical Education Index N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Kinematics; Posture; Step tests; Stepping; Landing; Kinetics; Balance; Performance; Women DO - http://dx.doi.org/10.1016/j.gaitpost.2006.06.001 ER - TY - JOUR T1 - Empirical therapy for diabetic foot infections: are there clinical clues to guide antibiotic selection? AN - 20451763; 9125366 AB - AbstractInitial antibiotic therapy for diabetic foot infections is usually empirical. Several principles may help to avoid selecting either an unnecessarily broad or inappropriately narrow regimen. First, clinically severe infections require broad-spectrum therapy, while less severe infections may not. Second, aerobic Gram-positive cocci, particularly Staphylococcus aureus (including methicillin-resistant S.aureus (MRSA) for patients at high-risk) should always be covered. Third, therapy should also be targeted at aerobic Gram-negative pathogens if the infection is chronic or has failed to respond to previous antibiotic therapy. Fourth, anti-anaerobe agents should be considered for necrotic or gangrenous infections on an ischaemic limb. Parenteral therapy is needed for severe infections, but oral therapy is adequate for most mild or moderate infections. JF - Clinical Microbiology and Infection AU - Lipsky, BA AD - 1University of Washington and, Benjamin.lipsky@med.va.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 351 EP - 353 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 13 IS - 4 SN - 1198-743X, 1198-743X KW - Microbiology Abstracts B: Bacteriology KW - Antibiotic therapy KW - diabetic foot infections KW - empirical therapy KW - foot infections KW - guidelines KW - treatment KW - Diabetes mellitus KW - Limbs KW - Drug resistance KW - Chronic infection KW - Foot KW - Gram-positive cocci KW - Risk groups KW - Antibiotics KW - Pathogens KW - Staphylococcus aureus KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20451763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+and+Infection&rft.atitle=Empirical+therapy+for+diabetic+foot+infections%3A+are+there+clinical+clues+to+guide+antibiotic+selection%3F&rft.au=Lipsky%2C+BA&rft.aulast=Lipsky&rft.aufirst=BA&rft.date=2007-04-01&rft.volume=13&rft.issue=4&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+and+Infection&rft.issn=1198743X&rft_id=info:doi/10.1111%2Fj.1469-0691.2007.01697.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Limbs; Drug resistance; Chronic infection; Foot; Risk groups; Gram-positive cocci; Antibiotics; Pathogens; Staphylococcus aureus DO - http://dx.doi.org/10.1111/j.1469-0691.2007.01697.x ER - TY - JOUR T1 - Quality of Life Among Implantable Cardioverter-Defibrillator Recipients in the Primary Prevention Therapeutic Era AN - 20033492; 7910408 AB - Background: Although patients receiving implantable cardioverter-defibrillators (ICDs) for primary prevention of sudden cardiac death are the fastest growing segment of the ICD recipient population, the quality-of-life (QOL) effects of the ICD among primary prevention patients are not well understood. The purpose of this study was to measure and compare the health-related QOL among primary and secondary prevention ICD recipients, and to determine predictive factors for high or low QOL in each group.Methods: Forty-five primary prevention and 75 secondary prevention ICD recipients receiving routine care in electrophysiology clinics within the University of Pennsylvania Health System were assessed using several well-validated general and ICD-specific QOL instruments.Results: Between primary and secondary prevention patients, there were no significant differences in EuroQol 5D (medians: 0.84 vs 0.84, P = 0.71), Health Utilities Index (medians: 0.88 vs 0.85, P = 0.95), Short Form-12 aggregate physical summary (means: 45 vs 46, P = 0.64), and Short Form-12 aggregate mental summary (means: 46 vs 47, P = 0.93) scores. Both primary and secondary prevention patients viewed their devices favorably according to the Florida Patient Acceptance Survey scale, with no significant differences between group means (80 vs 83, P = 0.71). However, substantial fractions of both primary and secondary prevention recipients had particular concerns about lifting (40%), sexual activity (19%), and driving (14%).Conclusions: QOL does not significantly differ between primary prevention and secondary prevention ICD recipients. Device recipients had comparable QOL to published, nationwide QOL estimates among non-ICD patients of similar age. The ICD was highly acceptable to most primary and secondary prevention patients. JF - Pacing and Clinical Electrophysiology AU - Groeneveld, Peter W AU - Matta, Mary A AU - Suh, Janice J AU - Yang, Feifei AU - Shea, Judy A AD - Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, peter.groeneveld@va.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 463 EP - 471 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 30 IS - 4 SN - 0147-8389, 0147-8389 KW - Biotechnology and Bioengineering Abstracts KW - defibrillators KW - implantable KW - quality of life KW - Heart KW - Age KW - Defibrillators KW - Electrophysiology KW - Cardiovascular diseases KW - Quality of life KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20033492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pacing+and+Clinical+Electrophysiology&rft.atitle=Quality+of+Life+Among+Implantable+Cardioverter-Defibrillator+Recipients+in+the+Primary+Prevention+Therapeutic+Era&rft.au=Groeneveld%2C+Peter+W%3BMatta%2C+Mary+A%3BSuh%2C+Janice+J%3BYang%2C+Feifei%3BShea%2C+Judy+A&rft.aulast=Groeneveld&rft.aufirst=Peter&rft.date=2007-04-01&rft.volume=30&rft.issue=4&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Pacing+and+Clinical+Electrophysiology&rft.issn=01478389&rft_id=info:doi/10.1111%2Fj.1540-8159.2007.00694.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Age; Defibrillators; Cardiovascular diseases; Electrophysiology; Quality of life DO - http://dx.doi.org/10.1111/j.1540-8159.2007.00694.x ER - TY - JOUR T1 - Characterization and Magnetic Resonance Imaging of a Rat Model of Human B-Cell Central Nervous System Lymphoma AN - 19655818; 7405299 AB - PURPOSE: The incidence of primary central nervous system lymphoma (PCNSL) is increasing. Therapeutic approaches remain controversial. An animal model that mimics the clinical situation would be useful for evaluating PCNSL biology and treatment. Experimental Design: Nude rats received intracerebral (caudate nucleus, n = 49) or intraventricular (n = 4) inoculation of human B-lymphoma cell line MC116. Two to five weeks after tumor inoculation, magnetic resonance imaging (MRI) was done (n = 24), and rat brains were assessed for pathology. Five rats each received whole-brain radiotherapy (WBRT, 20 Gy) or high-dose i.v. methotrexate (3 g/m super(2)). RESULTS: Intracerebral tumors developed in 84% of evaluable animals with no pretreatment, 79% of rats pretreated with 4 Gy total body irradiation, and 92% of rats pretreated with cyclophosphamide (300 mg/m super(2)). MRI showed abnormal T2 signal and gadolinium enhancement on T1-weighted images, consistent with tumor growth 19 to 24 days after inoculation. Tumor cells staining positively for B-lymphoma markers infiltrated within the inoculated hemisphere, along fiber tracks to the contralateral hemisphere, and along the subarachnoid space and ventricles. Tumors showed reactive gliosis. Intraventricular tumor cell injection resulted in periventricular parenchymal infiltration in both hemispheres. Radiation and methotrexate were effective in vitro, but only WBRT was clearly effective after 1 week in the intracerebral model. CONCLUSION: This model closely mimics human PCNSL in terms of imaging, histology, and treatment sensitivity and will be useful for the development of future therapeutic strategies for PCNSL. JF - Clinical Cancer Research AU - Soussain, Carole AU - Muldoon, Leslie L AU - Varallyay, Csanad AU - Jahnke, Kristoph AU - DePaula, Luciana AU - Neuwelt, Edward A AD - Authors' Affiliations: Departments of Neurology, Cell and Developmental Biology, Medicine, Radiation Oncology, and Neurosurgery, Oregon Health & Science University, and Veterans Administration Medical Center, Portland, Oregon Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 2504 EP - 2511 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 8 SN - 1078-0432, 1078-0432 KW - Immunology Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Central nervous system KW - Lymphocytes B KW - Gadolinium KW - Magnetic resonance imaging KW - Animal models KW - Brain KW - Radiotherapy KW - Caudate nucleus KW - Tumors KW - Cyclophosphamide KW - subarachnoid space KW - Tumor cells KW - Fibers KW - Radiation KW - Inoculation KW - Methotrexate KW - gliosis KW - Lymphoma KW - W 30910:Imaging KW - F 06915:Cancer Immunology KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19655818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Characterization+and+Magnetic+Resonance+Imaging+of+a+Rat+Model+of+Human+B-Cell+Central+Nervous+System+Lymphoma&rft.au=Soussain%2C+Carole%3BMuldoon%2C+Leslie+L%3BVarallyay%2C+Csanad%3BJahnke%2C+Kristoph%3BDePaula%2C+Luciana%3BNeuwelt%2C+Edward+A&rft.aulast=Soussain&rft.aufirst=Carole&rft.date=2007-04-01&rft.volume=13&rft.issue=8&rft.spage=2504&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Central nervous system; Lymphocytes B; Magnetic resonance imaging; Gadolinium; Brain; Animal models; Caudate nucleus; Radiotherapy; Cyclophosphamide; Tumors; subarachnoid space; Tumor cells; Fibers; Radiation; Inoculation; Methotrexate; gliosis; Lymphoma ER - TY - JOUR T1 - Maternal Nutrition, Low Nephron Number, and Hypertension in Later Life: Pathways of Nutritional Programming AN - 19614879; 7340069 AB - A large body of epidemiologic literature supports an inverse relation between birth weight and both systolic blood pressure and prevalence of hypertension, but mechanisms through which lower birth weight increases risk for hypertension are not established. This article advances the view that 1) permanently reduced nephron number is essential but not alone sufficient to mediate nutritionally induced hypertension; and 2) fetally programmed propensity for increased appetite and accelerated postnatal growth, thus generating inappropriately increased body mass, is a necessary "second hit" to actualize hypertension vulnerability. Based on decades of nephrologic research, this increased ratio of body mass (excretory load) to nephron number (excretory capacity) induces intrarenal compensations (tubular and glomerular hypertrophy with single-nephron hyperfiltration and intrarenal renin-angiotensin II activation), which maintain normal glomerular filtration rate at the expense of systemic and glomerular hypertension and at the risk of progressive renal disease. The vigor of the intrarenal compensatory responses is markedly greater in the immature than in the mature kidney, potentially explaining the greater risk of nephron deficits being present early in life as compared with the minimal risk in adult kidney donors. Effective interventions have not yet been defined. Suboptimal maternal nutrition, pervasive in both developed and developing countries, offers a window of opportunity to enhance the cardiovascular and renal health of future generations. JF - Journal of Nutrition AU - Bagby, Susan P AD - OHSU Heart Research Center and Division of Nephrology and Hypertension, Department of Medicine and Research Service, Oregon Health and Science University and Portland Veterans Administration Medical Center, Portland, OR 97239 Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 1066 EP - 1072 PB - American Society for Nutritional Sciences, 9650 Rockville Pike, Room L-2407A Bethesda MD 20814 USA, [mailto:staff@faseb.org], [URL:http://www.nutrition.org] VL - 137 IS - 4 SN - 0022-3166, 0022-3166 KW - Risk Abstracts KW - Filtration KW - body mass KW - intervention KW - hypertension KW - Kidney KW - birth weight KW - vulnerability KW - Nutrition KW - Developing countries KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19614879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrition&rft.atitle=Maternal+Nutrition%2C+Low+Nephron+Number%2C+and+Hypertension+in+Later+Life%3A+Pathways+of+Nutritional+Programming&rft.au=Bagby%2C+Susan+P&rft.aulast=Bagby&rft.aufirst=Susan&rft.date=2007-04-01&rft.volume=137&rft.issue=4&rft.spage=1066&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Filtration; body mass; intervention; hypertension; Kidney; birth weight; vulnerability; Developing countries; Nutrition ER - TY - CPAPER T1 - Aqueous Solution Chemistry of Zn(II) and Cd(II) with L-DOPA T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40566453; 4539159 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Rogers, Cassietta AU - Hamada, Yahia Z Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Levodopa KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40566453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Aqueous+Solution+Chemistry+of+Zn%28II%29+and+Cd%28II%29+with+L-DOPA&rft.au=Rogers%2C+Cassietta%3BHamada%2C+Yahia+Z&rft.aulast=Rogers&rft.aufirst=Cassietta&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of in Situ Hybridization as a Means of Assessing Immunoglobulin Light Chain Restriction in Plasma Cell and B Cell Neoplasia T2 - 96th Annual Meeting of the United States and Canadian Academy of Pathology AN - 40645413; 4575011 JF - 96th Annual Meeting of the United States and Canadian Academy of Pathology AU - Webber, B A AU - Cohen, C Y1 - 2007/03/24/ PY - 2007 DA - 2007 Mar 24 KW - Neoplasia KW - Lymphocytes B KW - Plasma cells KW - Light chains KW - Immunoglobulins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40645413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Evaluation+of+in+Situ+Hybridization+as+a+Means+of+Assessing+Immunoglobulin+Light+Chain+Restriction+in+Plasma+Cell+and+B+Cell+Neoplasia&rft.au=Webber%2C+B+A%3BCohen%2C+C&rft.aulast=Webber&rft.aufirst=B&rft.date=2007-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://test.pathologyportal.org/newindex.htm?96th/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Expert commentary: the safety of fibrates in lipid-lowering therapy. AN - 70281682; 17368273 AB - The use of fibrates in the management of lipoprotein disorders has a history dating back to the mid-1960s. This group of drugs has now been tested in several large long-term trials with cardiovascular end points. Overall, there is good evidence for the reduction of cardiovascular disease in primary prevention studies and in those of subjects with manifest disease. More recent trials have suffered from high interference due to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) introduction, particularly in their placebo control groups. However, there is very good evidence for overall safety from a combined study of >20,000 patients in these controlled clinical trials lasting approximately 5 years. Abdominal pain has been observed more frequently in the statin vs placebo group. Myopathy, liver enzyme elevations, and cholecystitis have been potential adverse reactions of interest. However, these have occurred at a very low rate and are rarely found to be statistically more frequent in the active-treatment group compared with the subjects taking placebo. The recent Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study found a slightly higher incidence of pancreatitis, deep venous thrombosis, and pulmonary embolism. Small creatinine and homocysteine elevations are observed in many patients taking fibrates, and the effect of this on long-term outcomes is under study. The FIELD study also described a significant reduction in the rates of progression of proteinuria and vascular retinopathy with fibrate therapy. To date, there has been no study exclusive to patients with elevated triglycerides, raising the question of the potential benefit of these drugs in patients with the lipid abnormalities most effectively treated with fibrates. JF - The American journal of cardiology AU - Brown, W Virgil AD - Emory University School of Medicine, Atlanta, Georgia, USA. w.virgil.brown@med.va.gov Y1 - 2007/03/19/ PY - 2007 DA - 2007 Mar 19 SP - 19C EP - 21C VL - 99 IS - 6A SN - 0002-9149, 0002-9149 KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - 0 KW - Hypolipidemic Agents KW - Clofibric Acid KW - 53PF01Q249 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Databases, Factual KW - Clinical Trials as Topic KW - Clofibric Acid -- therapeutic use KW - Hypolipidemic Agents -- therapeutic use KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Clofibric Acid -- adverse effects KW - Dyslipidemias -- drug therapy KW - Hypolipidemic Agents -- adverse effects KW - Cardiovascular Diseases -- prevention & control KW - Expert Testimony UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70281682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Expert+commentary%3A+the+safety+of+fibrates+in+lipid-lowering+therapy.&rft.au=Brown%2C+W+Virgil&rft.aulast=Brown&rft.aufirst=W&rft.date=2007-03-19&rft.volume=99&rft.issue=6A&rft.spage=19C&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-03 N1 - Date created - 2007-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association of specialist involvement and quality of care for Parkinson's disease. AN - 85411715; pmid-17260340 AB - Because Parkinson's disease (PD) has multiple neurological symptoms and often complex treatments, the quality of PD care may be higher when a specialist is involved. We examined the medical records, from 1998 to 2004, of 401 Los Angeles veterans with Parkinson's disease to determine whether care met key indicators of PD care quality. All care following a visit to a movement-disorder specialist or general neurologist was classified as specialty care. We compared adherence to each indicator by level of specialist involvement through logistic regression models. Over the study period, 10 indicators of PD care quality were triggered 2,227 times. Overall, movement disorder specialist involvement (78%) was associated with higher adherence to indicators than did general neurologist involvement (70%, P = 0.006) and nonneurologist involvement (52%, P < 0.001). The differences between movement disorder specialist and nonneurologist involvement were especially large for four indicators: treatment of wearing-off, assessments of falls, depression, and hallucinations. There is significant room for improving aspects of PD care quality among patients who do not have the involvement of a specialist. Quality of care interventions should involve specialists in management of motor symptoms and incorporate methods for routine assessment of nonmotor PD symptoms.(c) 2006 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Cheng, Eric M AU - Swarztrauber, Kari AU - Siderowf, Andrew D AU - Eisa, Mahmood S AU - Lee, Martin AU - Vassar, Stefanie AU - Jacob, Erin AU - Vickrey, Barbara G AD - Parkinson's Disease Research, Education, and Clinical Center (PADRECC), VA Greater Los Angeles Healthcare System, Los Angeles, California, USA. Eric.Cheng@va.gov Y1 - 2007/03/15/ PY - 2007 DA - 2007 Mar 15 SP - 515 EP - 522 VL - 22 IS - 4 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Demography KW - Female KW - Humans KW - Male KW - *Medicine: statistics & numerical data KW - Movement Disorders: diagnosis KW - Movement Disorders: therapy KW - *Neurology: statistics & numerical data KW - *Parkinson Disease: epidemiology KW - *Parkinson Disease: therapy KW - Quality Indicators, Health Care KW - *Quality of Health Care: standards KW - *Quality of Health Care: statistics & numerical data KW - *Specialization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85411715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Association+of+specialist+involvement+and+quality+of+care+for+Parkinson%27s+disease.&rft.au=Cheng%2C+Eric+M%3BSwarztrauber%2C+Kari%3BSiderowf%2C+Andrew+D%3BEisa%2C+Mahmood+S%3BLee%2C+Martin%3BVassar%2C+Stefanie%3BJacob%2C+Erin%3BVickrey%2C+Barbara+G&rft.aulast=Cheng&rft.aufirst=Eric&rft.date=2007-03-15&rft.volume=22&rft.issue=4&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - CPAPER T1 - Recovery of Proteins from Formalin-Fixed Paraffin-Embedded Tissues T2 - 51st Annual Meeting of the Biophysical Society AN - 40678346; 4581164 DE: JF - 51st Annual Meeting of the Biophysical Society AU - O'Leary, Timothy J AU - Fowler, Carol AU - Fabris, Dan AU - Mason, Jeffrey T Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40678346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Recovery+of+Proteins+from+Formalin-Fixed+Paraffin-Embedded+Tissues&rft.au=O%27Leary%2C+Timothy+J%3BFowler%2C+Carol%3BFabris%2C+Dan%3BMason%2C+Jeffrey+T&rft.aulast=O%27Leary&rft.aufirst=Timothy&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Oncology Nurses' Teaching and Support for Suicidal Patients AN - 61399247; 200705223 AB - Although the nursing literature contains many references to the nurses' teaching, support, and advocacy functions, the consumer and other health care professional literature suggests that the potential importance of nurses in these roles is not widely accepted. In a secondary analysis, we examined nurses' interventions for teaching and support in survey of a random sample of oncology nurses in a national organization. Clinical oncology nurses (n = 454) reported their attitudes to and knowledge about suicidal patients. They reported their goals, interventions, and emotional support for a suicidal patient. When nurses described their care, they rarely mentioned patient teaching, emotional support, and advocacy. A gap also existed between the recommended assessments, related goals, and interventions. The nurses' difficulties in responding therapeutically to suicidal patients also emerged from their religious/other values, uncomfortable feelings, inadequate knowledge, personal experiences, and weight of professional responsibility. A small percentage of oncology nurses with good psychiatric skills reported they had no difficulty in their caregiving role including teaching, support, and advocacy. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Psychosocial Oncology AU - Valente, Sharon M AD - PhD, FAAN, Assistant Chief Nurse, Center for Learning, Research and Innovation, Department of Veteran Affairs, Los Angeles, CA, 90073 Sharon.valente@med.va.gov Y1 - 2007/03/02/ PY - 2007 DA - 2007 Mar 02 SP - 121 EP - 137 PB - Haworth Press, Binghamton NY VL - 25 IS - 1 SN - 0734-7332, 0734-7332 KW - Caregivers KW - Nurses KW - Suicide KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61399247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychosocial+Oncology&rft.atitle=Oncology+Nurses%27+Teaching+and+Support+for+Suicidal+Patients&rft.au=Valente%2C+Sharon+M&rft.aulast=Valente&rft.aufirst=Sharon&rft.date=2007-03-02&rft.volume=25&rft.issue=1&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychosocial+Oncology&rft.issn=07347332&rft_id=info:doi/10.1300%2FJ077v25n01_07 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-12-10 N1 - Number of references - 27 N1 - Last updated - 2016-09-28 N1 - CODEN - JPONED N1 - SubjectsTermNotLitGenreText - Nurses; Suicide; Caregivers DO - http://dx.doi.org/10.1300/J077v25n01_07 ER - TY - JOUR T1 - Training Specific Treatment Techniques: The Next Step in Implementation of EBP? AN - 85652748; 200713926 AB - The current status of validity assessment of treatment evidence & its translation into evidence-based instructions for clinicians in speech/language pathology is reviewed, & a related training system for clinicians is proposed. References. J. Hitchcock JF - Journal of Medical Speech-Language Pathology AU - de Riesthal, Michael AD - Malcom Randall VA Medical Center, Gainesville, FL michael.deriesthal2@va.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - xi EP - xiv VL - 15 IS - 1 SN - 1065-1438, 1065-1438 KW - Speech/Language Therapists (83215) KW - Language Therapy (44400) KW - Professional Education (67900) KW - Meta Analyses (53070) KW - Research Design (72950) KW - Speech Therapy (83200) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85652748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Speech-Language+Pathology&rft.atitle=Training+Specific+Treatment+Techniques%3A+The+Next+Step+in+Implementation+of+EBP%3F&rft.au=de+Riesthal%2C+Michael&rft.aulast=de+Riesthal&rft.aufirst=Michael&rft.date=2007-03-01&rft.volume=15&rft.issue=1&rft.spage=xi&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Speech-Language+Pathology&rft.issn=10651438&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2007-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSLPEP N1 - SubjectsTermNotLitGenreText - Speech Therapy (83200); Language Therapy (44400); Research Design (72950); Speech/Language Therapists (83215); Professional Education (67900); Meta Analyses (53070) ER - TY - JOUR T1 - Psychiatric comorbidity does not predict interferon treatment completion rates in hepatitis C seropositive veterans. AN - 85412700; pmid-17426475 AB - The aim of this study was to evaluate the impact of common psychiatric disorders on treatment completion of antiviral therapy prescribed to a series of hepatitis C virus (HCV) positive US veterans.Clinical experience suggests that preexisting psychiatric conditions may adversely affect the ability to tolerate combination antiviral therapy in patients with HCV infection.We performed a retrospective chart review of 130 HCV positive veterans treated with combination antiviral therapy [interferon (IFN)/ribavirin] at VA San Diego from 2000 to 2004. We examined baseline psychiatric and substance use diagnoses, as well as demographic and comorbid medical disease variables for all patients started on treatment.Thirteen percent of patients in our cohort required treatment discontinuation for neuropsychiatric adverse effects. There was no association between treatment completion and any specific psychiatric diagnosis, baseline use of antidepressants, history of substance abuse/dependence, or combined psychiatric and substance use diagnoses for patient groups receiving either standard or pegylated IFN plus ribavirin therapies. Psychiatric and substance use disorders were not associated with dropout due to neuropsychiatric adverse effects. Baseline comorbid medical disorders also did not predict treatment completion. However, higher body weight did predict likelihood of treatment completion, especially for those > or =100 kg compared with thinner subjects (odds ratio=2.90; P=0.037).In this cohort of veterans, prior psychiatric or substance use history did not predict completion of recommended IFN/ribavirin treatment. These findings suggest that a larger pool of veterans with psychiatric or substance use disorders may be considered candidates for antiviral therapy when provided with multidisciplinary support. JF - Journal of clinical gastroenterology AU - Dollarhide, Adrian W AU - Loh, Catherine AU - Leckband, Susan G AU - Endow-Eyer, Rene AU - Robinson, Shannon AU - Meyer, Jonathan M AD - VA San Diego Healthcare System, San Diego, CA 92161, USA. adrian.dollarhide@med.va.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 322 EP - 328 VL - 41 IS - 3 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - *Antiviral Agents: therapeutic use KW - Comorbidity KW - Drug Therapy, Combination KW - Female KW - Hepatitis C: blood KW - *Hepatitis C: drug therapy KW - *Hepatitis C: epidemiology KW - Humans KW - *Interferons: therapeutic use KW - Male KW - *Mental Disorders: epidemiology KW - Middle Aged KW - *Patient Compliance: psychology KW - Patient Selection KW - Retrospective Studies KW - Ribavirin: therapeutic use KW - Veterans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85412700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Psychiatric+comorbidity+does+not+predict+interferon+treatment+completion+rates+in+hepatitis+C+seropositive+veterans.&rft.au=Dollarhide%2C+Adrian+W%3BLoh%2C+Catherine%3BLeckband%2C+Susan+G%3BEndow-Eyer%2C+Rene%3BRobinson%2C+Shannon%3BMeyer%2C+Jonathan+M&rft.aulast=Dollarhide&rft.aufirst=Adrian&rft.date=2007-03-01&rft.volume=41&rft.issue=3&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Therapeutic rationale of combining therapy with gemfibrozil and simvastatin. AN - 70510837; 17510000 AB - To examine specific indications for patients receiving therapy with gemfibrozil plus simvastatin at doses of more than 10 mg daily and determine whether these patient-specific indications met Adult Treatment Panel (ATP) III criteria for combination therapy; and secondarily to identify any complications occurring between August 30, 2002, and May 1, 2003. Retrospective cohort study. Tertiary care, university-affiliated, Southern Arizona Veterans Affairs Healthcare System from August 30, 2002, to May 1, 2003. 80 patients with active prescriptions for gemfibrozil at any dose and simvastatin at doses of more than 10 mg daily as of August 30, 2002; and 23 patients who had been prescribed this drug at other institutions. Retrospective chart review. Frequency of meeting ATP III criteria for combination therapy with gemfibrozil and simvastatin was the primary outcome measure (primary). Of the 80 patients, 45 (56%) met ATP III guidelines for combination therapy. Among the 80 patients started on these drugs at this VA facility, gemfibrozil was added to simvastatin in 61 patients, simvastatin was added to gemfibrozil in 18, and the agents were begun simultaneously for 1 patient. Common errors included combination treatment when LDL cholesterol values could not be calculated (because of serum triglycerides levels exceeding 400 mg/dL); use of gemfibrozil at triglyceride levels lower than the 500 mg/dL with attainment of non-HDL goals; and use of gemfibrozil when triglyceride levels were not measured. One death secondary to rhabdomyolysis occurred in a patient whose care did not meet ATP III guidelines. Combination therapy with simvastatin and gemfibrozil often did not meet ATP III standards. A higher risk of serious adverse events results from combining these drugs, and systems to improve adherence to guidelines may improve the safety of treating dyslipidemic patients. JF - Journal of the American Pharmacists Association : JAPhA AU - Curtin, Patrick O AU - Jones, William N AD - Southern Arizona Veterans Affairs (VA) Health Care System, Tucson, AZ, USA. curtin2@med.va.gov PY - 2007 SP - 140 EP - 146 VL - 47 IS - 2 KW - Hypolipidemic Agents KW - 0 KW - Simvastatin KW - AGG2FN16EV KW - Gemfibrozil KW - Q8X02027X3 KW - Index Medicus KW - Drug Therapy, Combination KW - Practice Patterns, Physicians' KW - Humans KW - Practice Guidelines as Topic KW - Middle Aged KW - Male KW - Female KW - Simvastatin -- therapeutic use KW - Simvastatin -- adverse effects KW - Hypolipidemic Agents -- therapeutic use KW - Hyperlipidemias -- drug therapy KW - Gemfibrozil -- therapeutic use KW - Hypolipidemic Agents -- adverse effects KW - Gemfibrozil -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70510837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Pharmacists+Association+%3A+JAPhA&rft.atitle=Therapeutic+rationale+of+combining+therapy+with+gemfibrozil+and+simvastatin.&rft.au=Curtin%2C+Patrick+O%3BJones%2C+William+N&rft.aulast=Curtin&rft.aufirst=Patrick&rft.date=2007-03-01&rft.volume=47&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Pharmacists+Association+%3A+JAPhA&rft.issn=1544-3450&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-29 N1 - Date created - 2007-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methamphetamine use in rural Midwesterners. AN - 70416513; 17453608 AB - Methamphetamine use has been characterized as a "rural" drug; however, little is known about rural methamphetamine use disorders (MUD). This study describes and compares characteristics of rural and urban patients with MUD. Rural study participants reported earlier first regular use of methamphetamine, more alcoholism, more intravenous use, and a greater number of cigarettes/day, and were more likely to report methamphetamine-related psychotic symptoms. Rural methamphetamine users report multiple factors that may contribute to medical and psychiatric complications and worsen their prognosis. This is of significant concern given the limited substance abuse, mental health, and specialty care available in most rural Midwestern communities. JF - The American journal on addictions AU - Grant, Kathleen M AU - Kelley, Stephanie Sinclair AU - Agrawal, Sangeeta AU - Meza, Jane L AU - Meyer, James R AU - Romberger, Debra J AD - University of Nebraska Medical Center, Omaha, Nebraska, USA. Kathleen.Grant2@med.va.gov PY - 2007 SP - 79 EP - 84 VL - 16 IS - 2 SN - 1055-0496, 1055-0496 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Urban Population -- statistics & numerical data KW - Mental Disorders -- epidemiology KW - Humans KW - Adult KW - Midwestern United States -- epidemiology KW - Male KW - Female KW - Rural Population -- statistics & numerical data KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70416513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Methamphetamine+use+in+rural+Midwesterners.&rft.au=Grant%2C+Kathleen+M%3BKelley%2C+Stephanie+Sinclair%3BAgrawal%2C+Sangeeta%3BMeza%2C+Jane+L%3BMeyer%2C+James+R%3BRomberger%2C+Debra+J&rft.aulast=Grant&rft.aufirst=Kathleen&rft.date=2007-03-01&rft.volume=16&rft.issue=2&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-10 N1 - Date created - 2007-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk-adjusting outcomes of mental health and substance-related care: a review of the literature. AN - 70415256; 17454175 AB - Risk adjustment is increasingly recognized as crucial to refining health care reimbursement and to comparing provider performance in terms of quality and outcomes of care. Risk adjustment for mental and substance use conditions has lagged behind other areas of medicine, but model development specific to these conditions has accelerated in recent years. After describing outcomes of mental health and substance-related care and associated risk factors, we review research studies on risk adjustment meeting the following criteria: (1) publication in a peer-reviewed journal between 1980 and 2002, (2) evaluation of one or more multivariate models used to risk-adjust comparisons of utilization, cost, or clinical outcomes of mental or substance use conditions across providers, and (3) quantitative assessment of the proportion of variance explained by patient characteristics in the model (e.g., R(2) or c-statistic). We identified 36 articles that included 72 models addressing utilization, 74 models of expenditures, and 15 models of clinical outcomes. Models based on diagnostic and sociodemographic information available from administrative data sets explained an average 6.7% of variance, whereas models using more detailed sources of data explained a more robust 22.8%. Results are appraised in the context of the mental health care system's needs for risk adjustment; we assess what has been accomplished, where gaps remain, and directions for future development. JF - Harvard review of psychiatry AU - Hermann, Richard C AU - Rollins, Caitlin K AU - Chan, Jeffrey A AD - The Center for Organization, Leadership and Management Research. Veterans Health Administration, Boston, MA, USA. rhermann@cqaimh.org PY - 2007 SP - 52 EP - 69 VL - 15 IS - 2 SN - 1067-3229, 1067-3229 KW - Index Medicus KW - Health Care Costs -- statistics & numerical data KW - Quality Assurance, Health Care -- statistics & numerical data KW - Quality Assurance, Health Care -- economics KW - Humans KW - Risk Adjustment -- statistics & numerical data KW - Mental Disorders -- rehabilitation KW - Outcome Assessment (Health Care) -- economics KW - Mental Health Services -- statistics & numerical data KW - Outcome Assessment (Health Care) -- statistics & numerical data KW - Risk Adjustment -- economics KW - Mental Health Services -- economics KW - Substance-Related Disorders -- economics KW - Substance-Related Disorders -- rehabilitation KW - Mental Disorders -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70415256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Harvard+review+of+psychiatry&rft.atitle=Risk-adjusting+outcomes+of+mental+health+and+substance-related+care%3A+a+review+of+the+literature.&rft.au=Hermann%2C+Richard+C%3BRollins%2C+Caitlin+K%3BChan%2C+Jeffrey+A&rft.aulast=Hermann&rft.aufirst=Richard&rft.date=2007-03-01&rft.volume=15&rft.issue=2&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Harvard+review+of+psychiatry&rft.issn=10673229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-29 N1 - Date created - 2007-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Avoidance coping strategies moderate the relationship between self-efficacy and 5-year alcohol treatment outcomes. AN - 70322192; 17385960 AB - Both self-efficacy and coping strategies are important determinants of functioning for substance use disorder patients, yet little is known about their interrelationship. This study examined the relationship between abstinence self-efficacy and cognitive components of coping (positive reappraisal, cognitive avoidance) for male participants (n = 2,596) from 15 residential substance use disorder treatment programs who were assessed at treatment entry, discharge, and 5-year follow-up. Cognitive avoidance coping moderated the effects of self-efficacy on alcohol use at 5 years, whereas positive reappraisal coping was largely unrelated to outcomes. Specifically, for patients with low self-efficacy, reliance on avoidance coping strategies was associated with poorer alcohol use outcomes, but as self-efficacy increased, the negative influence of avoidance coping strategies diminished. (c) 2007 APA, all rights reserved. JF - Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors AU - Levin, Cindy AU - Ilgen, Mark AU - Moos, Rudolf AD - Addiction Treatment Services, Department of Veterans Affairs Palo Alto Health Care System, Menlo Park, CA 94025, USA. Cindy.Levin@va.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 108 EP - 113 VL - 21 IS - 1 SN - 0893-164X, 0893-164X KW - Index Medicus KW - Humans KW - Adult KW - Treatment Outcome KW - Temperance KW - Time Factors KW - Secondary Prevention KW - Male KW - Cognition KW - Remission Induction KW - Substance-Related Disorders -- therapy KW - Substance Abuse Treatment Centers KW - Adaptation, Psychological KW - Self Efficacy KW - Avoidance Learning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70322192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+addictive+behaviors+%3A+journal+of+the+Society+of+Psychologists+in+Addictive+Behaviors&rft.atitle=Avoidance+coping+strategies+moderate+the+relationship+between+self-efficacy+and+5-year+alcohol+treatment+outcomes.&rft.au=Levin%2C+Cindy%3BIlgen%2C+Mark%3BMoos%2C+Rudolf&rft.aulast=Levin&rft.aufirst=Cindy&rft.date=2007-03-01&rft.volume=21&rft.issue=1&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Psychology+of+addictive+behaviors+%3A+journal+of+the+Society+of+Psychologists+in+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-14 N1 - Date created - 2007-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of tardive dyskinesia with galantamine: a randomized controlled crossover trial. AN - 70308424; 17388711 AB - Recent evidence suggests that tar-dive dyskinesia may result from antipsychotic-induced damage to striatal cholinergic neurons. To test whether cholinesterase inhibitors compensate for diminished cholinergic activity, we conducted a 30-week randomized, double-blind, placebo-controlled crossover trial of galantamine in patients with tardive dyskinesia. Patients with tardive dyskinesia were recruited between June 2001 and June 2004. After a 2-week baseline period, 35 male schizophrenia patients, on stable doses of antipsychotics, were randomly assigned to receive galantamine (8-24 mg) or placebo for two 12-week phases separated by a 4-week washout period. Patients were evaluated every 2 weeks for changes in extrapyramidal symptoms and before and after each treatment for effects on psychiatric symptoms and cognition. Galantamine reduced mean total Abnormal Involuntary Movement Scale (AIMS) scores more than placebo, but this difference was not statistically significant (p = .08). However, patients initially randomly assigned to galantamine showed a reversal of AIMS scores after switching to placebo. Simpson-Angus Scale ratings of parkinsonism were significantly higher with galantamine than placebo (p = .0005) and correlated with age. There were no significant differences between groups in akathisia, cognition, or psychiatric symptoms. More patients dropped out while receiving galantamine, but this outcome did not significantly influence the results. In contrast to previous reports, reductions in tardive dyskinesia associated with galantamine were not statistically significant compared with placebo in this trial. However, galantamine was associated with a modest rebound in dyskinesia scores after discontinuation and clinically minor but statistically higher ratings of parkinsonism. These findings support the need for further investigations of cholinergic mechanisms underlying tardive dyskinesia and extrapyramidal effects of cholinesterase inhibitors when used in combination with antipsychotics in susceptible patients. ClinicalTrials.gov identifier NCT00164242. JF - The Journal of clinical psychiatry AU - Caroff, Stanley N AU - Walker, Patricia AU - Campbell, Cabrina AU - Lorry, Alan AU - Petro, Christopher AU - Lynch, Kevin AU - Gallop, Robert AD - Department of Veterans Affairs Medical Center, University of Pennsylvania School of Medicine, Philadelphia, USA. stanley.caroff@va.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 410 EP - 415 VL - 68 IS - 3 KW - Antipsychotic Agents KW - 0 KW - Cholinesterase Inhibitors KW - Galantamine KW - 0D3Q044KCA KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Antipsychotic Agents -- therapeutic use KW - Adult KW - Treatment Outcome KW - Cross-Over Studies KW - Schizophrenia -- drug therapy KW - Middle Aged KW - Antipsychotic Agents -- adverse effects KW - Male KW - Dyskinesia, Drug-Induced -- drug therapy KW - Cholinesterase Inhibitors -- therapeutic use KW - Galantamine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70308424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Treatment+of+tardive+dyskinesia+with+galantamine%3A+a+randomized+controlled+crossover+trial.&rft.au=Caroff%2C+Stanley+N%3BWalker%2C+Patricia%3BCampbell%2C+Cabrina%3BLorry%2C+Alan%3BPetro%2C+Christopher%3BLynch%2C+Kevin%3BGallop%2C+Robert&rft.aulast=Caroff&rft.aufirst=Stanley&rft.date=2007-03-01&rft.volume=68&rft.issue=3&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=1555-2101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-03 N1 - Date created - 2007-03-28 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00164242; ClinicalTrials.gov N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interpersonal trauma, war zone exposure, and posttraumatic stress disorder among veterans with schizophrenia. AN - 70237267; 17276658 AB - The present study examined the prevalence of war zone exposure, interpersonal trauma and post-traumatic stress disorder (PTSD) in veterans with primary schizophrenia hospitalized on a VA inpatient psychiatric unit. Data were collected on a sample of male veterans (N=165) with a primary diagnosis of schizophrenia or schizoaffective disorder, who were consecutively admitted to a VAMC inpatient psychiatric unit. The prevalence of interpersonal trauma exposure and comorbid PTSD were assessed. Analyses also explored differences between those patients who had been identified with PTSD to those who screened positive but had not been previously identified as having PTSD. Ninety-six percent of the sample endorsed interpersonal trauma or exposure to a war zone. The prevalence of PTSD was 47% (n=78), although only 14% (n=11) of those who screened positive for PTSD had a diagnosis of PTSD in their medical record. Among those screening positive, having a chart diagnosis of PTSD was associated with more severe PTSD symptoms and combat exposure. Results suggest that PTSD is highly prevalent and under-diagnosed among veterans with schizophrenia. Increased assessment of trauma and PTSD in this population is warranted. JF - Schizophrenia research AU - Calhoun, Patrick S AU - Stechuchak, Karen M AU - Strauss, Jennifer AU - Bosworth, Hayden B AU - Marx, Christine E AU - Butterfield, Marian I AD - VA Mid-Atlantic Region Mental Illness Research, Education and Clinical Center (116B), 508 Fulton Street, Veterans Affairs Medical Center, Durham, NC 27705, USA. Patrick.Calhoun2@va.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 210 EP - 216 VL - 91 IS - 1-3 SN - 0920-9964, 0920-9964 KW - Index Medicus KW - Severity of Illness Index KW - Child Abuse -- statistics & numerical data KW - Humans KW - Child KW - Mass Screening -- methods KW - Psychotic Disorders -- epidemiology KW - Hospitalization KW - Psychotic Disorders -- psychology KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Psychotic Disorders -- diagnosis KW - Male KW - Substance-Related Disorders -- epidemiology KW - Prevalence KW - Warfare KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Veterans -- statistics & numerical data KW - Interpersonal Relations KW - Veterans -- psychology KW - Schizophrenia -- rehabilitation KW - Schizophrenia -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70237267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=Interpersonal+trauma%2C+war+zone+exposure%2C+and+posttraumatic+stress+disorder+among+veterans+with+schizophrenia.&rft.au=Calhoun%2C+Patrick+S%3BStechuchak%2C+Karen+M%3BStrauss%2C+Jennifer%3BBosworth%2C+Hayden+B%3BMarx%2C+Christine+E%3BButterfield%2C+Marian+I&rft.aulast=Calhoun&rft.aufirst=Patrick&rft.date=2007-03-01&rft.volume=91&rft.issue=1-3&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-12 N1 - Date created - 2007-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anxiety, anxiety disorders, tobacco use, and nicotine: a critical review of interrelationships. AN - 70234477; 17338599 AB - Smoking is highly prevalent across most anxiety disorders. Tobacco use increases risk for the later development of certain anxiety disorders, and smokers with anxiety disorders have more severe withdrawal symptoms during smoking cessation than smokers without anxiety disorders. The authors critically examined the relationships among anxiety, anxiety disorders, tobacco use, and nicotine dependence and reviewed the existing empirical literature. Future research is needed to better understand the interrelationships among these variables, including predictors, moderators, and mechanisms of action. Increased knowledge in these areas should inform prevention efforts as well as the development and improvement of smoking cessation programs for those with anxiety and other psychiatric disorders. JF - Psychological bulletin AU - Morissette, Sandra Baker AU - Tull, Matthew T AU - Gulliver, Suzy Bird AU - Kamholz, Barbara Wolfsdorf AU - Zimering, Rose T AD - Department of Psychiatry, Boston University School of Medicine, Boston, MA 02130, USA. sandra.morissette@va.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 245 EP - 272 VL - 133 IS - 2 SN - 0033-2909, 0033-2909 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Anxiety -- psychology KW - Humans KW - Anxiety -- epidemiology KW - Prevalence KW - Substance Withdrawal Syndrome -- etiology KW - Anxiety Disorders -- psychology KW - Tobacco Use Disorder -- epidemiology KW - Substance Withdrawal Syndrome -- epidemiology KW - Nicotine -- adverse effects KW - Tobacco Use Disorder -- psychology KW - Anxiety Disorders -- epidemiology KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70234477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+bulletin&rft.atitle=Anxiety%2C+anxiety+disorders%2C+tobacco+use%2C+and+nicotine%3A+a+critical+review+of+interrelationships.&rft.au=Morissette%2C+Sandra+Baker%3BTull%2C+Matthew+T%3BGulliver%2C+Suzy+Bird%3BKamholz%2C+Barbara+Wolfsdorf%3BZimering%2C+Rose+T&rft.aulast=Morissette&rft.aufirst=Sandra&rft.date=2007-03-01&rft.volume=133&rft.issue=2&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Psychological+bulletin&rft.issn=00332909&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-24 N1 - Date created - 2007-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Postoperative cognitive dysfunction in older patients with a history of alcohol abuse. AN - 70209029; 17325499 AB - Postoperative cognitive dysfunction (POCD) affects a significant number of patients and may have serious consequences for quality of life. Although POCD is most frequent after cardiac surgery, the prevalence of POCD after noncardiac surgery in older patients is also significant. The risk factors for POCD after noncardiac surgery include advanced age and preexisting cognitive impairment. Self-reported alcohol abuse is a risk factor for postoperative delirium, but its significance for long-term POCD has not been investigated. The goal of this study was to determine whether neurocognitive function is impaired after noncardiac surgery during general anesthesia in older patients with a history of alcohol abuse. Subjects aged 55 yr and older with self-reported alcohol abuse (n = 28) and age-, sex-, education-matched nonalcoholic controls (n = 28) were tested using a neurocognitive battery before and 2 weeks after elective surgery (n = 28) or a corresponding time interval without surgery (n = 28). Verbal memory, visuospatial memory, and executive functions were assessed. A neurologic examination was performed to exclude subjects with potential cerebrovascular damage. Significant three-way interactions (analysis of variance) for Visual Immediate Recall, Visual Delayed Recall, Semantic Fluency, Phonemic Fluency, and the Color-Word Stroop Test implied that cognitive performance in the alcoholic group decreased after surgery more than it did in the other three groups. The results suggest that a history of alcohol abuse in older patients presents a risk for postoperative cognitive impairment in the domains of visuospatial abilities and executive functions that may have important implications for quality of life and health risks. JF - Anesthesiology AU - Hudetz, Judith A AU - Iqbal, Zafar AU - Gandhi, Sweeta D AU - Patterson, Kathleen M AU - Hyde, Trevor F AU - Reddy, Diane M AU - Hudetz, Anthony G AU - Warltier, David C AD - Clinical Research, Department of Anesthesiology, Medical College of Wisconsin and Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin 53295, USA. judith.hudetz@va.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 423 EP - 430 VL - 106 IS - 3 SN - 0003-3022, 0003-3022 KW - Abridged Index Medicus KW - Index Medicus KW - Neuropsychological Tests -- statistics & numerical data KW - Analysis of Variance KW - Elective Surgical Procedures -- adverse effects KW - Humans KW - Aged KW - Surgical Procedures, Operative -- adverse effects KW - Memory, Short-Term -- drug effects KW - Visual Perception -- drug effects KW - Comorbidity KW - Anesthesia, General -- adverse effects KW - Space Perception -- drug effects KW - Cognition -- drug effects KW - Aged, 80 and over KW - Risk Factors KW - Middle Aged KW - Mental Recall -- drug effects KW - Male KW - Prevalence KW - Cognition Disorders -- diagnosis KW - Alcoholism -- epidemiology KW - Cognition Disorders -- epidemiology KW - Postoperative Complications -- epidemiology KW - Postoperative Complications -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70209029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=Postoperative+cognitive+dysfunction+in+older+patients+with+a+history+of+alcohol+abuse.&rft.au=Hudetz%2C+Judith+A%3BIqbal%2C+Zafar%3BGandhi%2C+Sweeta+D%3BPatterson%2C+Kathleen+M%3BHyde%2C+Trevor+F%3BReddy%2C+Diane+M%3BHudetz%2C+Anthony+G%3BWarltier%2C+David+C&rft.aulast=Hudetz&rft.aufirst=Judith&rft.date=2007-03-01&rft.volume=106&rft.issue=3&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Anesthesiology&rft.issn=00033022&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-01 N1 - Date created - 2007-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Levorphanol: the forgotten opioid. AN - 69000884; 17039381 AB - Levorphanol (levo-3-hydroxy-N-methylmorphinan) is a strong opioid that is the only available opioid agonist of the morphinan series. Levorphanol was originally synthesized as a pharmacological alternative to morphine more than 40 years ago. It is considered a step-3 opioid by the World Health Organization (WHO) and has a greater potency than morphine. Analgesia produced by levorphanol is mediated via its interactions with mu, delta, and kappa opioid receptors. Levorphanol is also an N-methyl-D-aspartate (NMDA) receptor antagonist. There is evidence that levorphanol may inhibit uptake of norepinephrine and serotonin. Similar to morphine, levorphanol undergoes glucuronidation in the liver, and the glucuronidated products are excreted in the kidney. Levorphanol can be given orally, intravenously, and subcutaneously. This article reviews the pharmacodynamics, pharmacology, and clinical efficacy for this often overlooked step-3 opioid. The long half-life of the drug increases the potential for drug accumulation. Levorphanol has clinical efficacy in neuropathic pain. JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer AU - Prommer, Eric AD - VIP Palliative Care Program, Greater Los Angeles Healthcare, Division of Hematology/Oncology, UCLA School of Medicine, 11301 Wilshire 111-H, Los Angeles, CA, USA. eric.prommer@med.va.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 259 EP - 264 VL - 15 IS - 3 SN - 0941-4355, 0941-4355 KW - Analgesics, Opioid KW - 0 KW - Receptors, N-Methyl-D-Aspartate KW - Receptors, Opioid KW - Levorphanol KW - 27618J1N2X KW - Index Medicus KW - Administration, Oral KW - Receptors, Opioid -- agonists KW - Drug Administration Schedule KW - Pain -- drug therapy KW - Injections, Intravenous KW - Humans KW - Receptors, Opioid -- drug effects KW - Injections, Intramuscular KW - Therapeutic Equivalency KW - Pain -- etiology KW - Neoplasms -- complications KW - Receptors, N-Methyl-D-Aspartate -- drug effects KW - Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors KW - Levorphanol -- pharmacokinetics KW - Analgesics, Opioid -- pharmacology KW - Analgesics, Opioid -- therapeutic use KW - Levorphanol -- administration & dosage KW - Analgesics, Opioid -- pharmacokinetics KW - Levorphanol -- adverse effects KW - Analgesics, Opioid -- adverse effects KW - Analgesics, Opioid -- administration & dosage KW - Levorphanol -- therapeutic use KW - Levorphanol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69000884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.atitle=Levorphanol%3A+the+forgotten+opioid.&rft.au=Prommer%2C+Eric&rft.aulast=Prommer&rft.aufirst=Eric&rft.date=2007-03-01&rft.volume=15&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.issn=09414355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-10 N1 - Date created - 2007-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment setting and baseline substance use severity interact to predict patients' outcomes. AN - 69000794; 17298651 AB - This study tested the hypothesis that patients with more severe substance use disorders (SUDs) at intake respond better when treated in more structured and intensive settings (i.e. in-patient/residential versus out-patient), whereas patients with less severe SUD problems have similar outcomes regardless of treatment setting. Up to 50 new patients were selected randomly from each of a random and representative sample of 50 Department of Veterans Affairs (VA) SUD treatment programs (total n = 1917 patients), and were followed-up an average of 6.7 months later (n = 1277). Patients completed a brief self-report version of the Addiction Severity Index (ASI) at baseline and at follow-up. In mixed-model regression analyses, baseline substance use severity predicted follow-up substance use severity and there were no main effects of treatment setting. However, interaction effects were found, such that more severe patients experienced better alcohol and drug outcomes following in-patient/residential treatment versus out-patient treatment; on the other hand, patients with lower baseline ASI drug severity had better drug outcomes following out-patient treatment than in-patient treatment. Treatment setting was unrelated to alcohol outcomes in patients with less severe ASI alcohol scores. Results provide some support to the matching hypothesis that for patients who have higher levels of substance use severity at intake, treatment in in-patient/residential treatment settings is associated with better outcomes than out-patient treatment. More research needs to be conducted before in-patient/residential settings are further reduced as a part of the SUD continuum of care in the United States. JF - Addiction (Abingdon, England) AU - Tiet, Quyen Q AU - Ilgen, Mark A AU - Byrnes, Hilary F AU - Harris, Alex H S AU - Finney, John W AD - Center for Health Care Evaluation, Department of Veterans Affairs, Palo Alto Health Care System, Menlo Park, CA 94025, USA. quyen.tiet@va.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 432 EP - 440 VL - 102 IS - 3 SN - 0965-2140, 0965-2140 KW - Index Medicus KW - Severity of Illness Index KW - Ambulatory Care -- methods KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Psychotherapy -- methods KW - Residential Treatment -- methods KW - Veterans KW - Treatment Outcome KW - Follow-Up Studies KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Male KW - Substance-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69000794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Treatment+setting+and+baseline+substance+use+severity+interact+to+predict+patients%27+outcomes.&rft.au=Tiet%2C+Quyen+Q%3BIlgen%2C+Mark+A%3BByrnes%2C+Hilary+F%3BHarris%2C+Alex+H+S%3BFinney%2C+John+W&rft.aulast=Tiet&rft.aufirst=Quyen&rft.date=2007-03-01&rft.volume=102&rft.issue=3&rft.spage=432&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-16 N1 - Date created - 2007-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Different components of opioid-substitution treatment predict outcomes of patients with and without a parent with substance-use problems. AN - 68990140; 17286334 AB - The aim of this study was to determine how the treatment needs and outcomes of polysubstance-using patients entering opioid-substitution treatment (OST) may be affected if the patient had a parent with substance-use problems. This prospective observational study examined outcomes of 255 patients (97% male) entering OST at eight clinics in the Veterans Health Administration. Self-reported substance-use outcomes in the first year of treatment were compared between patients with (n = 121) and without (n = 134) a parent with substance-use problems. The association between receipt of practice guideline-recommended elements of care and treatment outcome was examined. Parent history-positive patients had greater drug use at 6 months, but by 12 months they had reduced their drug use to the same extent as parent history-negative patients. Ongoing methadone (Dolophine, Methadose) maintenance was associated with improved outcomes of drug use in parent history-negative patients; however, parent history-positive patients who ended methadone maintenance reduced drug use as much as those who continued treatment. The association between treatment received and outcome differed in these populations. In parent history-negative patients, reduced severity of substance use at 1 year was predicted solely by receiving methadone for a greater number of days. In parent history-positive patients, reduced severity of substance use was predicted by receiving methadone for fewer days, by greater satisfaction with and receipt of counseling services, and by lesser tendency for providers to encourage a reduction in methadone use. The importance of counseling and medication components of OST may differ depending on family history. For parent history-negative patients, medication maintenance may be more therapeutically necessary. JF - Journal of studies on alcohol and drugs AU - Trafton, Jodie A AU - Tracy, Stephen W AU - Oliva, Elizabeth M AU - Humphreys, Keith AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System and Stanford University Medical School, 795 Willow Road (152-MPD), Menlo Park, California 94025, USA. Jodie.Trafton@med.va.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 165 EP - 172 VL - 68 IS - 2 SN - 1937-1888, 1937-1888 KW - Narcotics KW - 0 KW - Methadyl Acetate KW - L59OC40KWJ KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - United States KW - Combined Modality Therapy KW - Dose-Response Relationship, Drug KW - Guideline Adherence KW - Humans KW - Cocaine-Related Disorders -- psychology KW - Child KW - Counseling KW - Cocaine-Related Disorders -- rehabilitation KW - Cocaine-Related Disorders -- genetics KW - Substance Abuse Detection KW - Adult KW - Treatment Outcome KW - Heroin Dependence -- rehabilitation KW - Patient Dropouts -- psychology KW - Middle Aged KW - Follow-Up Studies KW - Heroin Dependence -- psychology KW - Heroin Dependence -- genetics KW - Male KW - Female KW - Hospitals, Veterans KW - Alcoholism -- rehabilitation KW - Methadone -- therapeutic use KW - Opioid-Related Disorders -- psychology KW - Child of Impaired Parents -- psychology KW - Veterans -- psychology KW - Narcotics -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation KW - Methadyl Acetate -- therapeutic use KW - Opioid-Related Disorders -- genetics KW - Alcoholism -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68990140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol+and+drugs&rft.atitle=Different+components+of+opioid-substitution+treatment+predict+outcomes+of+patients+with+and+without+a+parent+with+substance-use+problems.&rft.au=Trafton%2C+Jodie+A%3BTracy%2C+Stephen+W%3BOliva%2C+Elizabeth+M%3BHumphreys%2C+Keith&rft.aulast=Trafton&rft.aufirst=Jodie&rft.date=2007-03-01&rft.volume=68&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol+and+drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2007-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Update in calcium deposition diseases. AN - 68985652; 17278931 AB - Calcium pyrophosphate dihydrate and basic calcium phosphate crystals are common components of osteoarthritic synovial fluids and define subsets of patients with inflammatory or rapidly destructive arthritis. Recent literature concerning clinical and etiologic aspects of calcium pyrophosphate dihydrate and basic calcium phosphate crystal arthritis are reviewed. Recent literature reminds us of the propensity of calcium pyrophosphate dihydrate deposition disease to mimic other syndromes affecting the elderly. Several new studies reinforce the prevalence and significance of extra-articular calcium pyrophosphate dihydrate deposits, and demonstrate the presence of basic calcium phosphate-like whitlockite crystals in intervertebral discs. Current work serves to increase our appreciation for the complex role of the putative pyrophosphate transporter, ANKH, in healthy and diseased cartilage. The application of newer radiographic techniques to the diagnosis of calcium pyrophosphate dihydrate deposition disease holds promise for easier and more accurate identification of these crystal deposits in vivo. Work demonstrating the efficacy of a crystal poison in an animal model of osteoarthritis provides good evidence for a pathogenic role of calcium crystals in osteoarthritis, and hope for new therapies for these diseases. Continued work will further our understanding of these common crystals and their associated clinical syndromes. JF - Current opinion in rheumatology AU - Rosenthal, Ann K AD - Medical College of Wisconsin, Zablocki VA Medical Center, Milwaukee, Wisconsin 53295-1000, USA. ann.rosenthal@med.va.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 158 EP - 162 VL - 19 IS - 2 SN - 1040-8711, 1040-8711 KW - ANKH protein, human KW - 0 KW - Phosphate Transport Proteins KW - Calcium Pyrophosphate KW - X69NU20D19 KW - Index Medicus KW - Humans KW - Arthritis -- etiology KW - Calcium Pyrophosphate -- metabolism KW - Chondrocalcinosis -- diagnosis KW - Chondrocalcinosis -- physiopathology KW - Chondrocalcinosis -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68985652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+rheumatology&rft.atitle=Update+in+calcium+deposition+diseases.&rft.au=Rosenthal%2C+Ann+K&rft.aulast=Rosenthal&rft.aufirst=Ann&rft.date=2007-03-01&rft.volume=19&rft.issue=2&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+rheumatology&rft.issn=10408711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-29 N1 - Date created - 2007-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Sexual Lives of Lesbian, Gay, and Bisexual People with Disabilities: Psychological Perspectives AN - 61659205; 200720382 AB - People with disabilities (PWD) who identify as lesbian, gay, or bisexual (LGB) represent a population that has received little attention in the areas of social policy, sexuality studies, and psychological research and practice. Existing research, especially from psychological perspectives, has focused mostly on sexual identity and internal psychological dimensions rather than on actual physical experiences and sexual expression. Awareness of the unique needs and concerns of these individuals is crucial for optimizing their physical and mental well-being, especially for those who provide mental health services for those who identify as LGB PWD. This article presents these issues from a multicultural perspective, viewing this population as a double minority with some experiences similar to those of other minority groups. Further, it provides a practical view of barriers to sexual expression for LGB PWD along with strategies for overcoming them and describes suggestions for further work in advocacy, social policy, and research. Adapted from the source document. JF - Sexuality Research and Social Policy: Journal of NSRC AU - Fraley, Sarah S AU - Mona, Linda R AU - Theodore, Peter S AD - VA Long Beach Healthcare System, CA sarah.fraley@med.va.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 15 EP - 26 PB - University of California Press, Berkeley VL - 4 IS - 1 SN - 1553-6610, 1553-6610 KW - Lesbianism KW - Handicapped KW - Social Policy KW - Psychological Research KW - Constraints KW - Homosexuality KW - article KW - 1940: the family and socialization; sociology of sexual behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61659205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexuality+Research+and+Social+Policy%3A+Journal+of+NSRC&rft.atitle=The+Sexual+Lives+of+Lesbian%2C+Gay%2C+and+Bisexual+People+with+Disabilities%3A+Psychological+Perspectives&rft.au=Fraley%2C+Sarah+S%3BMona%2C+Linda+R%3BTheodore%2C+Peter+S&rft.aulast=Fraley&rft.aufirst=Sarah&rft.date=2007-03-01&rft.volume=4&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Sexuality+Research+and+Social+Policy%3A+Journal+of+NSRC&rft.issn=15536610&rft_id=info:doi/10.1525%2Fsrsp.2007.4.1.15 L2 - http://caliber.ucpress.net LA - English DB - Sociological Abstracts N1 - Date revised - 2007-08-31 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social Policy; Handicapped; Homosexuality; Lesbianism; Psychological Research; Constraints DO - http://dx.doi.org/10.1525/srsp.2007.4.1.15 ER - TY - JOUR T1 - Internalizing and Externalizing Subtypes in Female Sexual Assault Survivors: Implications for the Understanding of Complex PTSD AN - 57306307; 200916045 AB - This study replicated and extended findings of internalizing and externalizing subtypes of posttraumatic psychopathology (Miller, M. W., Greif, J. L., & Smith, A. A. (2003). Multidimensional Personality Questionnaire profiles of veterans with traumatic combat exposure: Internalizing and externalizing subtypes. Psychological Assessment, 15, 205-215; Miller, M. W., Kaloupek, D. G., Dillon, A. L., & Keane, T.M. (2004). Externalizing and internalizing subtypes of combat-related PTSD: A replication and extension using the PSY-5 Scales. Journal of Abnormal Psychology, 113, 636-645) to a female sample of rape survivors with chronic PTSD. Cluster analyses of Schedule for Nonadaptive and Adaptive Personality (Clark, L. A. (1996). SNAP-Schedule for Nonadaptive and Adaptive Personality: Manual for administration, scoring, and interpretation. Minneapolis: University of Minnesota Press.) temperament scale profiles from 143 women with PTSD partitioned the sample into a simple PTSD cluster, defined by normal range personality scores and moderate symptomatology, and 2 more 'complex' clusters distinguished by more severe tendencies towards externalizing or internalizing psychopathology. Externalizers were characterized by disinhibition, substance dependence, and Cluster B personality disorder features; internalizers by low positive temperament, high rates of major depressive disorder, and elevations on measures of schizoid and avoidant personality disorder. [Copyright Association for Behavioral and Cognitive Therapies. Published by Elsevier Ltd.] JF - Behavior Therapy AU - Miller, Mark W AU - Resick, Patricia A AD - National Center for PTSD, VA Boston Healthcare System mark.miller5@va.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 58 EP - 71 PB - Elsevier Ltd, The Netherlands VL - 38 IS - 1 SN - 0005-7894, 0005-7894 KW - Posttraumatic stress disorder KW - Subtypes KW - Internalization KW - Personality KW - Externalizing behaviour KW - Psychopathology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57306307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Therapy&rft.atitle=Internalizing+and+Externalizing+Subtypes+in+Female+Sexual+Assault+Survivors%3A+Implications+for+the+Understanding+of+Complex+PTSD&rft.au=Miller%2C+Mark+W%3BResick%2C+Patricia+A&rft.aulast=Miller&rft.aufirst=Mark&rft.date=2007-03-01&rft.volume=38&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Behavior+Therapy&rft.issn=00057894&rft_id=info:doi/10.1016%2Fj.beth.2006.04.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Externalizing behaviour; Internalization; Posttraumatic stress disorder; Personality; Subtypes; Psychopathology DO - http://dx.doi.org/10.1016/j.beth.2006.04.003 ER - TY - JOUR T1 - A Psychoeducational Program for Iranian Family Caregivers Living in Northern California AN - 57293455; 200913645 AB - This paper provides a description of a pilot (feasibility) study conducted with Iranian caregivers in northern CA. The intervention program was based on a previously successful program with ethnically diverse dementia family caregivers; it was 'tailored' for Persian caregivers, most of whom were Farsi-speaking. A brief description of the intervention is provided, along with a summary of evaluation data collected. Caregivers were very appreciative of the opportunity both to talk about their caregiving distress, and to learn skills for better coping. A complete Farsi translation of the culturally modified 'coping with caregiving' class was one of the endproducts of this pilot study. Adapted from the source document. JF - Clinical Gerontologist AU - Azar, Armin AU - Dadvar, Shukofeh AD - Veterans Administration Palo Alto Health Care Service, Palo Alto, CA, USA Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 95 EP - 100 PB - Haworth Press/Taylor & Francis, Philadelphia PA VL - 31 IS - 3 SN - 0731-7115, 0731-7115 KW - Translation KW - Pilot studies KW - Farsi language KW - Dementia KW - Coping KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57293455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Gerontologist&rft.atitle=A+Psychoeducational+Program+for+Iranian+Family+Caregivers+Living+in+Northern+California&rft.au=Azar%2C+Armin%3BDadvar%2C+Shukofeh&rft.aulast=Azar&rft.aufirst=Armin&rft.date=2007-03-01&rft.volume=31&rft.issue=3&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Clinical+Gerontologist&rft.issn=07317115&rft_id=info:doi/10.1080%2F07317110802072249 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - CODEN - CLGEDA N1 - SubjectsTermNotLitGenreText - Carers; Coping; Dementia; Translation; Pilot studies; Farsi language DO - http://dx.doi.org/10.1080/07317110802072249 ER - TY - JOUR T1 - Organizational and Unit Factors Contributing to Reduction in the Use of Seclusion and Restraint Procedures on an Acute Psychiatric Inpatient Unit AN - 57224885; 200715945 AB - Objective: The use of seclusion or restraint (S/R) as an emergency medical intervention to assist patients in regaining behavioral control continues to be an area of interest and concern for the Joint Commission on the Accreditation of Healthcare Organizations (JCAHO), consistent with the ongoing concerns in the medical, patient advocate, legislative and legal communities. This study examined unit characteristics and the use of S/R in a VA facility with a secured, acute mental health unit before and after the promulgation of the JCAHO 2000 standards for utilization of S/R for behavioral health reasons. Methods: Variables examined include patient acuity, patient census, number of admits, number of discharges, length of stay, number of nursing staff on duty, critical incidents and S/R hours per month. Results: Results indicated S/R use began showing a notable decrease corresponding to the time that senior unit management began discussions of the new JCAHO standards. These reductions maintained statistical significance even after controlling for changes in unit environmental variables. Adapted from the source document. JF - Psychiatric Quarterly AU - Pollard, Richard AU - Yanasak, Elisia V AU - Rogers, Steven A AU - Tapp, Andre AD - VA Puget Sound Health Care System, American Lake Division, Mental Health Service, (A-116-R), 9600 Veterans Dr. S.W, Tacoma 98493, USA E-mail: Elisia.Yanasak@med.va.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 73 EP - 81 PB - Springer. New York NY VL - 78 IS - 1 SN - 0033-2720, 0033-2720 KW - Seclusion, Restraint, Inpatient psychiatry KW - Reduction KW - Inpatient treatment units KW - National guidelines KW - Psychiatric hospitals KW - Restraints KW - Seclusion KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57224885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+Quarterly&rft.atitle=Organizational+and+Unit+Factors+Contributing+to+Reduction+in+the+Use+of+Seclusion+and+Restraint+Procedures+on+an+Acute+Psychiatric+Inpatient+Unit&rft.au=Pollard%2C+Richard%3BYanasak%2C+Elisia+V%3BRogers%2C+Steven+A%3BTapp%2C+Andre&rft.aulast=Pollard&rft.aufirst=Richard&rft.date=2007-03-01&rft.volume=78&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Psychiatric+Quarterly&rft.issn=00332720&rft_id=info:doi/10.1007%2Fs11126-006-9028-5 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-08-28 N1 - Last updated - 2016-09-27 N1 - CODEN - PSQUAP N1 - SubjectsTermNotLitGenreText - National guidelines; Psychiatric hospitals; Inpatient treatment units; Seclusion; Restraints; Reduction DO - http://dx.doi.org/10.1007/s11126-006-9028-5 ER - TY - JOUR T1 - Primary care-mental health collaboration: An example of assessing usual practice and potential barriers AN - 57059501; 200718752 AB - Practice guidelines include recommendations for collaboration between primary care (PC) and mental health (MH) to improve the quality of depression management within primary care. There is little research, however, assessing usual care relationships between PC and MH providers, or providers' perceptions regarding collaboration. Based on the literature, we conceptualize a continuum of collaborative activities and strategies. We describe the extent of collaboration and perceived barriers in selected outpatient clinics. We conducted semi-structured interviews with 22 PC and MH clinical leaders from 10 outpatient facilities. Topics included existing referral, consultation, and collaboration practices between PC and MH, beliefs and barriers related to collaboration. Informants generally described good relationships between providers, and PC providers reported satisfaction with referrals to MH. Informal consultation also occurred, although it was not universal. There was little evidence of collaboration beyond this basic level. The leaders identified several potential barriers to collaboration, including inadequate staffing and resources for both services. In contrast with practice guidelines, the clinics we studied incorporated little collaboration with MH providers into PC management of depression. We identify strategies that can help overcome the barriers to collaboration that our informants most commonly identified. Adapted from the source document. JF - Journal of Interprofessional Care AU - Fickel, Jacqueline J AU - Parker, Louise E AU - Yano, Elizabeth M AU - Kirchner, Joann E AD - Veterans Administration, Health Services Research and Development Service, Center for the Study of Healthcare Provider Behavior, Los Angeles, California Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 207 EP - 216 PB - Taylor & Francis, Abingdon UK VL - 21 IS - 2 SN - 1356-1820, 1356-1820 KW - Barriers KW - Depression KW - Primary health care professionals KW - Mental health professionals KW - Practice KW - Collaborative case management KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57059501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interprofessional+Care&rft.atitle=Primary+care-mental+health+collaboration%3A+An+example+of+assessing+usual+practice+and+potential+barriers&rft.au=Fickel%2C+Jacqueline+J%3BParker%2C+Louise+E%3BYano%2C+Elizabeth+M%3BKirchner%2C+Joann+E&rft.aulast=Fickel&rft.aufirst=Jacqueline&rft.date=2007-03-01&rft.volume=21&rft.issue=2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interprofessional+Care&rft.issn=13561820&rft_id=info:doi/10.1080%2F13561820601132827 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JINCFT N1 - SubjectsTermNotLitGenreText - Primary health care professionals; Mental health professionals; Collaborative case management; Depression; Practice; Barriers DO - http://dx.doi.org/10.1080/13561820601132827 ER - TY - JOUR T1 - Lipopolysaccharide modulation of thyrotropin-releasing hormone (TRH) and TRH-like peptide levels in rat brain and endocrine organs AN - 21319400; 12041059 AB - Lipopolysaccharide (LPS) is a proinflammatory and depressogenic agent whereas thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an endogenous antidepressant and neuroprotective peptide. LPS and TRH also have opposing effects on K channel conductivity. We hypothesized that LPS can modulate the expression and release of not only TRH but also TRH-like peptides with the general structure pGlu-X-Pro-NH2, where 'X' can be any amino acid residue. The response might be 'homeostatic,' that is, LPS might increase TRH and TRH-like peptide release, thereby moderating the cell damaging effects of this bacterial cell wall constituent. On the other hand, LPS might impair the synthesis and release of these neuropeptides, thus facilitating the induction of early response genes, cytokines, and other downstream biochemical changes that contribute to the 'sickness syndrome.' JF - Journal of Molecular Neuroscience AU - Pekary, Albert Eugene AU - Stevens, Schetema A AU - Sattin, Albert AD - Research Service, University of Calitornia, 90073 Los Angeles, CA, Eugene.Pekary@va.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 245 EP - 259 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 31 IS - 3 SN - 0895-8696, 0895-8696 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Antidepressants KW - Nervous system KW - Thyrotropin-releasing hormone KW - Amino acids KW - Brain KW - Lipopolysaccharides KW - Cytokines KW - Neuroprotection KW - Neuropeptides KW - Cell walls KW - Inflammation KW - J 02410:Animal Diseases KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21319400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Neuroscience&rft.atitle=Lipopolysaccharide+modulation+of+thyrotropin-releasing+hormone+%28TRH%29+and+TRH-like+peptide+levels+in+rat+brain+and+endocrine+organs&rft.au=Pekary%2C+Albert+Eugene%3BStevens%2C+Schetema+A%3BSattin%2C+Albert&rft.aulast=Pekary&rft.aufirst=Albert&rft.date=2007-03-01&rft.volume=31&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Neuroscience&rft.issn=08958696&rft_id=info:doi/10.1385%2FJMN%3A31%3A03%3A245 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Antidepressants; Nervous system; Amino acids; Thyrotropin-releasing hormone; Brain; Cytokines; Lipopolysaccharides; Neuroprotection; Neuropeptides; Inflammation; Cell walls DO - http://dx.doi.org/10.1385/JMN:31:03:245 ER - TY - JOUR T1 - Effect of Motorized Scooters on Physical Performance and Mobility: A Randomized Clinical Trial AN - 20440750; 7891356 JF - Archives of Physical Medicine and Rehabilitation AU - Hoenig, H AU - Pieper, C AU - Branch, L G AU - Cohen, HJ AD - Physical Medicine and Rehabilitation Service, Durham Veterans Administration Medical Center, Durham, NC, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 279 EP - 286 VL - 88 IS - 3 SN - 0003-9993, 0003-9993 KW - Physical Education Index KW - Performance KW - Archives KW - Movement KW - PE 110:Physical Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20440750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Effect+of+Motorized+Scooters+on+Physical+Performance+and+Mobility%3A+A+Randomized+Clinical+Trial&rft.au=Hoenig%2C+H%3BPieper%2C+C%3BBranch%2C+L+G%3BCohen%2C+HJ&rft.aulast=Hoenig&rft.aufirst=H&rft.date=2007-03-01&rft.volume=88&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/10.1016%2Fj.apmr.2006.11.022 LA - English DB - Physical Education Index N1 - Date revised - 2008-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Archives; Movement; Performance DO - http://dx.doi.org/10.1016/j.apmr.2006.11.022 ER - TY - JOUR T1 - Reduction in Midthigh Low-Density Muscle with Aerobic Exercise Training and Weight Loss Impacts Glucose Tolerance in Older Men AN - 19607819; 7316441 AB - CONTEXT: Intramuscular lipid content increases with aging and obesity and is directly related to impaired glucose tolerance and insulin resistance. OBJECTIVE: Our purpose was to determine the effects of aerobic exercise training (AEX) with and without weight loss (WL) on midthigh low-density muscle (LDM; a measure of im lipid) and whether changes in LDM impact glucose tolerance in sedentary older men. DESIGN: Forty-six men (60.4 plus or minus 1.1 yr) completed 6 months of AEX (n = 34) or AEX + WL (n = 12) and had oral glucose tolerance tests (OGTTs) and computed tomography measures of LDM and regional abdominal and thigh fat depot areas. RESULTS: At baseline, LDM area directly correlated with fasting plasma glucose (FPG), 120-min glucose (G sub(120)), and glucose area under the curve (G sub(AUC)) during an OGTT (r = 0.44, r = 0.51, and r = 0.54, respectively, P < 0.01). After the interventions, the AEX + WL group had greater decreases in LDM (-13.5 vs. +1.3%, respectively), FPG (-8.3 vs. +2.1%, respectively), G sub(120) (-22.5 vs. -3.6%, respectively), and G sub(AUC) (-17.3 vs. - 3.1%, respectively) than the AEX group. In the entire sample, the decreases in LDM correlated with reductions in FPG, G sub(120), and G sub(AUC) during an OGTT (r = 0.31, r = 0.34, and r = 0.41, P < 0.05). Changes in other regional fat depots did not independently correlate with glucose tolerance or insulin responses. CONCLUSION: AEX + WL is more efficacious than AEX for reducing LDM and glucose tolerance. The improvement in glucose tolerance may be partially mediated by decreases in LDM in older men. JF - Journal of Clinical Endocrinology and Metabolism AU - Prior, Steven J AU - Joseph, Lyndon J AU - Brandauer, Josef AU - Katzel, Leslie I AU - Hagberg, James M AU - Ryan, Alice S AD - Division of Gerontology, University of Maryland School of Medicine and Baltimore Geriatric Research, Education and Clinical Center (S.J.P., L.J.J., L.I.K., J.M.H., A.S.R.), Veterans Administration Maryland Health Care System, Baltimore, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 880 EP - 886 PB - Endocrine Society, 4350 East West Highway Suite 500 Bethesda MD 20814-4426 USA, [mailto:societyservices@endo-society.org], [URL:http://www.endo-society.org/] VL - 92 IS - 3 SN - 0021-972X, 0021-972X KW - Physical Education Index KW - Obesity KW - Exercise physiology KW - Weight control KW - Aerobics KW - Men KW - Muscles (exercise effects) KW - Lipids KW - Gerontology KW - Blood glucose KW - Legs KW - Hormones KW - Exercise (programs) KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19607819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.atitle=Reduction+in+Midthigh+Low-Density+Muscle+with+Aerobic+Exercise+Training+and+Weight+Loss+Impacts+Glucose+Tolerance+in+Older+Men&rft.au=Prior%2C+Steven+J%3BJoseph%2C+Lyndon+J%3BBrandauer%2C+Josef%3BKatzel%2C+Leslie+I%3BHagberg%2C+James+M%3BRyan%2C+Alice+S&rft.aulast=Prior&rft.aufirst=Steven&rft.date=2007-03-01&rft.volume=92&rft.issue=3&rft.spage=880&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Obesity; Exercise physiology; Weight control; Aerobics; Muscles (exercise effects); Men; Lipids; Gerontology; Blood glucose; Legs; Exercise (programs); Hormones ER - TY - JOUR T1 - Localization of Cocaine Analog [ super(125)I]RTI 82 Irreversible Binding to Transmembrane Domain 6 of the Dopamine Transporter AN - 19603704; 7316289 AB - The site of cocaine binding on the dopamine transporter (DAT) was investigated using the photoactivatable irreversible cocaine analog [ super(125)I]3 beta -(p-chlorophenyl)tropane-2 beta -carboxylic acid, 4'-azido-3'-iodophenylethyl ester ([ super(125)I]RTI 82). The incorporation site of this compound was mapped to transmembrane domains (TMs) 4-6 using epitope-specific immunoprecipitation of trypsin fragments and further localized using cyanogen bromide (CNBr), which hydrolyzes proteins on the C-terminal side of methionine residues. CNBr hydrolysis of [ super(125)I]RTI 82-labeled rat striatal and expressed human DATs produced fragments of similar to 5-10 kDa consistent with labeling between Met super(271/272) or Met super(290) in TM5 to Met super(370/371) in TM7. To further define the incorporation site, substitution mutations were made that removed endogenous methionines and inserted exogenous methionines in combinations that would generate labeled CNBr fragments of distinct masses depending on the labeling site. The results obtained were consistent with the presence of TM6 but not TMs 4, 5, or 7 in the labeled fragments, with additional support for these conclusions obtained by epitope-specific immunoprecipitation and secondary digestion of CNBr fragments with endoproteinase Lys-C. The final localization of [ super(125)I]RTI 82 incorporation to rat DAT Met super(290)-Lys super(336) and human DAT I291M to R344M provides positive evidence for the proximity of cocaine binding to TM6. Residues in and near DAT TM6 regulate transport and transport-dependent conformational states, and TM6 forms part of the substrate permeation pathway in the homologous Aquifex aeolicus leucine transporter. Cocaine binding near TM6 may thus overlap the dopamine translocation pathway and function to inhibit TM6 structural rearrangements necessary for transport. JF - Journal of Biological Chemistry AU - Vaughan, Roxanne A AU - Sakrikar, Dhananjay S AU - Parnas, MLaura AU - Adkins, Steven AU - Foster, James D AU - Duval, Romain A AU - Lever, John R AU - Kulkarni, Santosh S AU - Hauck-Newman, Amy AD - Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203-9037, the Departments of Radiology, and Medical Pharmacology and Physiology, University of Missouri and the Harry S. Truman Veterans Administration Medical Center, Columbia, Missouri 65212, and the Medicinal Chemistry Section, Intramural Research Program, National Institute on Drug Abuse, Bethesda, Maryland 21224 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 8915 EP - 8925 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 12 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Amino acid substitution KW - Trypsin KW - Immunoprecipitation KW - bromides KW - Esters KW - Transmembrane domains KW - Hydrolysis KW - Methionine KW - Dopamine transporter KW - Aquifex aeolicus KW - Neostriatum KW - Leucine KW - Cocaine KW - Translocation KW - N3 11008:Neurochemistry KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19603704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Localization+of+Cocaine+Analog+%5B+super%28125%29I%5DRTI+82+Irreversible+Binding+to+Transmembrane+Domain+6+of+the+Dopamine+Transporter&rft.au=Vaughan%2C+Roxanne+A%3BSakrikar%2C+Dhananjay+S%3BParnas%2C+MLaura%3BAdkins%2C+Steven%3BFoster%2C+James+D%3BDuval%2C+Romain+A%3BLever%2C+John+R%3BKulkarni%2C+Santosh+S%3BHauck-Newman%2C+Amy&rft.aulast=Vaughan&rft.aufirst=Roxanne&rft.date=2007-03-01&rft.volume=282&rft.issue=12&rft.spage=8915&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Amino acid substitution; Trypsin; Immunoprecipitation; Transmembrane domains; Esters; bromides; Hydrolysis; Methionine; Dopamine transporter; Neostriatum; Leucine; Cocaine; Translocation; Aquifex aeolicus ER - TY - JOUR T1 - Non-treatment-seeking heavy drinkers: Effects of chronic cigarette smoking on brain structure AN - 57204633; 200712824 AB - We previously reported [Cardenas, V.A., Studholme, C., Meyerhoff, D.J., Song, E., Weiner, M.W., 2005. Chronic active heavy drinking and family history of problem drinking modulate regional brain tissue volumes. Psychiatry Res. 138, 115-130] that non-treatment-seeking, active heavy drinkers (HD) demonstrated smaller regional neocortical gray matter volumes compared to light drinking controls, however, the potential effects of chronic cigarette smoking on regional brain volumes were not addressed. The goal of this retrospective analysis was to determine if chronic smoking affected brain structure in the non-treatment-seeking heavy drinking sample from our earlier report (i.e., Cardenas et al., 2005). Regional volumetric comparisons were made among age-matched smoking HD (n = 17), non-smoking HD (n = 16), and non-smoking light drinkers (nsLD; n = 20) from our original sample. Quantitative volumetric measures of neocortical gray matter (GM), white matter (WM), subcortical structures, and cerebral spinal fluid (CSF) were derived from high-resolution magnetic resonance imaging. Smoking HD demonstrated smaller volumes than nsLD in the frontal, parietal, temporal GM, and for total neocortical GM. Smoking HD also demonstrated smaller temporal and total GM volumes than non-smoking RD. Non-smoking HD and nsLD did not differ significantly on GM volumes. Further, the three groups did not differ on lobar WM, subcortical structures or regional CSF volumes. These retrospective analyses indicate neocortical GM volume reductions in non-treatment-seeking smoking HD, but not in non-smoking HD, which are consistent with our studies in recently detoxified treatment-seeking alcohol-dependent samples. [Copyright 2006 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Durazzo, Timothy C AU - Cardenas, Valerie A AU - Studholme, Cohn AU - Weiner, Michael W AU - Meyerhoff, Dieter J AD - Center Neuroimaging Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, CA timothy.durazzo@ucsf.edu Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 SP - 76 EP - 82 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 87 IS - 1 SN - 0376-8716, 0376-8716 KW - Alcoholism, Chronic cigarette smoking, MRI, Brain volume, Neuroimaging KW - Smoking KW - Neuroimaging KW - Brain structure KW - Alcoholism KW - Heavy drinking KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57204633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Non-treatment-seeking+heavy+drinkers%3A+Effects+of+chronic+cigarette+smoking+on+brain+structure&rft.au=Durazzo%2C+Timothy+C%3BCardenas%2C+Valerie+A%3BStudholme%2C+Cohn%3BWeiner%2C+Michael+W%3BMeyerhoff%2C+Dieter+J&rft.aulast=Durazzo&rft.aufirst=Timothy&rft.date=2007-02-23&rft.volume=87&rft.issue=1&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2006.08.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-31 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Alcoholism; Heavy drinking; Smoking; Brain structure; Helpseeking; Neuroimaging DO - http://dx.doi.org/10.1016/j.drugalcdep.2006.08.003 ER - TY - CPAPER T1 - Alcohol Dependence Severity Predicts Cigarette Craving in Patients Seeking Concurrent Alcohol and Tobacco Treatment T2 - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AN - 40656045; 4579027 JF - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AU - Perry, Bridget L AU - Cohen, Emily AU - Steinberg, Howard R AU - Pilkey, David T AU - Carbone, Michael AU - Cooney, Judith L AU - Litt, Mark D AU - Oncken, Cheryl A AU - Cooney, Ned L Y1 - 2007/02/21/ PY - 2007 DA - 2007 Feb 21 KW - Alcohols KW - Tobacco KW - Ethanol KW - Cigarettes KW - Drug dependence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40656045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Alcohol+Dependence+Severity+Predicts+Cigarette+Craving+in+Patients+Seeking+Concurrent+Alcohol+and+Tobacco+Treatment&rft.au=Perry%2C+Bridget+L%3BCohen%2C+Emily%3BSteinberg%2C+Howard+R%3BPilkey%2C+David+T%3BCarbone%2C+Michael%3BCooney%2C+Judith+L%3BLitt%2C+Mark+D%3BOncken%2C+Cheryl+A%3BCooney%2C+Ned+L&rft.aulast=Perry&rft.aufirst=Bridget&rft.date=2007-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=&rft_id=info:doi/ L2 - http://www.srnt.org/meeting/2007/pdf/onsite/2007SRNTAbstracts-FINAL.pd f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Barriers in the management of glucocorticoid-induced osteoporosis. AN - 69038753; 17266078 AB - To determine present practice for the management of glucocorticoid-induced osteoporosis (GIOP) in veterans; to characterize provider knowledge, beliefs, and practice behaviors regarding management of GIOP; and to identify potential barriers and interventions in the management of GIOP. To characterize current management of GIOP in an academic veterans administration medical center, we conducted a retrospective chart review of 100 patients who were prescribed a 90-day supply of prednisone. To assess clinicians' knowledge of GIOP clinical guidelines and perceptions of GIOP management, primary care clinicians and subspecialists completed a questionnaire and participated in focus groups. Chart review revealed that only 32 of 100 patients receiving long-term glucocorticoid treatment underwent bone mineral density testing, and only 32 patients were prescribed the recommended calcium supplements. Of the 23 providers who completed the questionnaire and participated in the focus groups, 4 correctly identified both the dose and duration of glucocorticoid use at which GIOP prevention measures should be instituted. Common GIOP management barriers cited by participants were lack of knowledge, having limited time during the clinic visit to address all problems, patient nonadherence, and system problems. The most commonly mentioned potential interventions were the use of computerized clinical reminders and patient education. Clinicians frequently do not follow recommended guidelines for the management of GIOP. Improving the management of GIOP will likely require a fundamental redesigning of care processes for this disorder in order to overcome provider, patient-related, and system barriers. JF - Arthritis and rheumatism AU - Guzman-Clark, Jenice Ria S AU - Fang, Meika A AU - Sehl, Mary E AU - Traylor, Laural AU - Hahn, Theodore J AD - VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA. jenice.guzman@med.va.gov Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 140 EP - 146 VL - 57 IS - 1 SN - 0004-3591, 0004-3591 KW - Calcium, Dietary KW - 0 KW - Glucocorticoids KW - Prednisone KW - VB0R961HZT KW - Abridged Index Medicus KW - Index Medicus KW - Arthritis, Rheumatoid -- drug therapy KW - Guideline Adherence KW - Humans KW - Retrospective Studies KW - Aged KW - Focus Groups KW - Patient Education as Topic KW - Aged, 80 and over KW - Risk Factors KW - Health Surveys KW - Middle Aged KW - Calcium, Dietary -- therapeutic use KW - Female KW - Male KW - Hospitals, Veterans KW - Osteoporosis -- prevention & control KW - Clinical Competence KW - Prednisone -- adverse effects KW - Prednisone -- therapeutic use KW - Osteoporosis -- drug therapy KW - Glucocorticoids -- adverse effects KW - Glucocorticoids -- therapeutic use KW - Osteoporosis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69038753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+and+rheumatism&rft.atitle=Barriers+in+the+management+of+glucocorticoid-induced+osteoporosis.&rft.au=Guzman-Clark%2C+Jenice+Ria+S%3BFang%2C+Meika+A%3BSehl%2C+Mary+E%3BTraylor%2C+Laural%3BHahn%2C+Theodore+J&rft.aulast=Guzman-Clark&rft.aufirst=Jenice+Ria&rft.date=2007-02-15&rft.volume=57&rft.issue=1&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Arthritis+and+rheumatism&rft.issn=00043591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-08 N1 - Date created - 2007-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Commonalities and Variations in the Cash and Counseling Programs across the Three Demonstration States AN - 919970803; 201202739 AB - ObjectiveTo describe the key features of the first three Cash and Counseling demonstration programs and identify those which the programs have in common and those on which they differ. Study SettingDemonstration Cash and Counseling programs in Arkansas, Florida, and New Jersey. Data SourcesInterviews with program staff and program materials and discussion. MethodsDescription and comparison. Principal Findings ConclusionThe three Cash and Counseling demonstration programs have many common features; these arose because they were required to adhere to the basic tenets of the Cash and Counseling model and to federal regulations, to share the philosophy of consumer empowerment, and to work together to design their programs. However, their programs also differ substantially due to differences in state goals, Medicaid programs, and political environments. These variations must be taken into account to understand differences in the impact of the three programs. Tables, References. Adapted from the source document. JF - Health Services Research AU - Phillips, Barbara AU - Schneider, Barbara AD - Veterans Health Administration, 520 Galer St., Unit 300, Seattle Washington 98109 Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 397 EP - 413 PB - Blackwell Publishers, Oxford UK VL - 42 IS - 1p2 SN - 0017-9124, 0017-9124 KW - Cash and Counseling consumer direction long-term care KW - Goals KW - Political culture KW - Counselling KW - Regulations KW - Empowerment KW - Demonstrations KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919970803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Commonalities+and+Variations+in+the+Cash+and+Counseling+Programs+across+the+Three+Demonstration+States&rft.au=Phillips%2C+Barbara%3BSchneider%2C+Barbara&rft.aulast=Phillips&rft.aufirst=Barbara&rft.date=2007-02-01&rft.volume=42&rft.issue=1p2&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2006.00677.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Counselling; Demonstrations; Empowerment; Political culture; Regulations; Goals DO - http://dx.doi.org/10.1111/j.1475-6773.2006.00677.x ER - TY - JOUR T1 - Oxidative stress pathways in the potentiation of noise-induced hearing loss by acrylonitrile. AN - 85402059; pmid-17222524 AB - We hypothesize that the disruption of antioxidant defenses is a key mechanism whereby chemical contaminants can potentiate noise-induced hearing loss (NIHL). This hypothesis was tested using acrylonitrile (ACN), a widely used industrial chemical whose metabolism is associated with glutathione (GSH) depletion and cyanide (CN) generation. CN, in turn, can inhibit Cu/Zn superoxide dismutase (SOD). We have shown previously that ACN potentiates NIHL, even with noise exposure approaching permissible occupational levels. However, the relative involvement of GSH depletion and/or CN production in this potentiation is still unknown. In this study, we altered these metabolic pathways pharmacologically in order to further delineate the role of specific antioxidants in the protection of the cochlea. We investigated the effects of sodium thiosulfate (STS), a CN inhibitor, 4-methylpyrazole (4MP), a drug that blocks CN generation by competing with CYP2E1, and l-N-acetylcysteine (l-NAC), a pro-GSH drug, in order to distinguish between GSH depletion and CN production as the mechanism responsible for potentiation of NIHL by ACN. Long-Evans rats were exposed to an octave-band noise (97 dB SPL, 4h/day, 5 days) and ACN (50 mg/kg). Separate pre-treatments with STS (150 mg/kg), 4MP (100 mg/kg) and l-NAC (4 x 400 mg/kg) all dramatically reduced blood CN levels, but only l-NAC significantly protected GSH levels in both the liver and the cochlea. Concurrently, only l-NAC treatment decreased the auditory loss and hair cell loss resulting from ACN + noise, suggesting that GSH is involved in the protection of the cochlea against reactive oxygen species generated by moderate noise levels. On the other hand, CN does not seem to be involved in this potentiation. JF - Hearing research AU - Pouyatos, Benoît AU - Gearhart, Caroline AU - Nelson-Miller, Alisa AU - Fulton, Sherry AU - Fechter, Laurence AD - Jerry Pettis Memorial Veterans Medical Center, Department of Veterans Affairs Medical Center, 11201 Benton Street, Loma Linda, CA 92357, United States. benoit.pouyatos@med.va.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 61 EP - 74 VL - 224 IS - 1-2 SN - 0378-5955, 0378-5955 KW - Index Medicus KW - National Library of Medicine KW - Acetylcysteine: pharmacology KW - Acrylonitrile: metabolism KW - *Acrylonitrile: toxicity KW - Action Potentials KW - Animals KW - Antioxidants: metabolism KW - Cochlea: drug effects KW - Cochlea: metabolism KW - Cochlea: pathology KW - Cochlea: physiopathology KW - Cyanides: metabolism KW - Glutathione: metabolism KW - *Hearing Loss, Noise-Induced: etiology KW - *Hearing Loss, Noise-Induced: metabolism KW - Hearing Loss, Noise-Induced: pathology KW - Hearing Loss, Noise-Induced: physiopathology KW - Liver: drug effects KW - Liver: metabolism KW - Male KW - Otoacoustic Emissions, Spontaneous KW - *Oxidative Stress: drug effects KW - Pyrazoles: pharmacology KW - Rats KW - Rats, Long-Evans KW - Reactive Oxygen Species: metabolism KW - Thiosulfates: pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85402059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+research&rft.atitle=Oxidative+stress+pathways+in+the+potentiation+of+noise-induced+hearing+loss+by+acrylonitrile.&rft.au=Pouyatos%2C+Beno%C3%AEt%3BGearhart%2C+Caroline%3BNelson-Miller%2C+Alisa%3BFulton%2C+Sherry%3BFechter%2C+Laurence&rft.aulast=Pouyatos&rft.aufirst=Beno%C3%AEt&rft.date=2007-02-01&rft.volume=224&rft.issue=1-2&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Hearing+research&rft.issn=03785955&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Hepatitis C treatment candidacy and outcomes among 4318 US veterans with chronic hepatitis C virus infection: does a history of injection drug use matter? AN - 85389777; pmid-17245220 AB - Many patients with a history of injection drug use (IDU) are excluded from hepatitis C virus (HCV) treatment. This prospective multicenter study aimed to determine the impact of IDU history on HCV treatment candidacy and outcomes.Between 1999 and 2001, 4318 HCV-infected patients seen at 24 VA Medical Centers were evaluated for HCV treatment candidacy and followed prospectively. Univariate and multivariate logistic regression analyses were used to determine whether an IDU history was associated with HCV treatment candidacy, HCV treatment acceptance, early treatment discontinuation, and virologic response.Of 4318 participants, 2611 (61%) reported an IDU history. IDU history was not significantly associated with HCV treatment candidacy, acceptance, early discontinuation of therapy, or virologic response (all P values nonsignificant). Instead, reduced HCV treatment candidacy was independently associated with low-income [odds ratio (OR)=1.46, 95% confidence interval (CI)=1.22-1.74), education or = 3 drinks/d (OR=2.08, 95% CI=1.68-2.57), whereas early discontinuation of HCV therapy was independently associated with low-income and consuming > or = 3 alcoholic drinks/d.A history of IDU was not associated with HCV treatment candidacy or outcomes, supporting national guidelines to evaluate former IDUs on a case-by-case basis for HCV treatment. JF - Journal of clinical gastroenterology AU - Seal, Karen H AU - Currie, Sue L AU - Shen, Hui AU - Anand, Bhupinderjit S AU - Bini, Edmund J AU - Brau, Norbert AU - Jeffers, Lennox AU - Wright, Teresa L AD - VA Medical Center, San Francisco, CA 94121, USA. Karen.Seal@va.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 199 EP - 205 VL - 41 IS - 2 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Antiviral Agents: adverse effects KW - Drug Therapy, Combination KW - Female KW - *Hepatitis C, Chronic: therapy KW - Humans KW - Male KW - Middle Aged KW - *Patient Selection KW - *Substance Abuse, Intravenous KW - Treatment Outcome KW - United States KW - *Veterans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85389777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Hepatitis+C+treatment+candidacy+and+outcomes+among+4318+US+veterans+with+chronic+hepatitis+C+virus+infection%3A+does+a+history+of+injection+drug+use+matter%3F&rft.au=Seal%2C+Karen+H%3BCurrie%2C+Sue+L%3BShen%2C+Hui%3BAnand%2C+Bhupinderjit+S%3BBini%2C+Edmund+J%3BBrau%2C+Norbert%3BJeffers%2C+Lennox%3BWright%2C+Teresa+L&rft.aulast=Seal&rft.aufirst=Karen&rft.date=2007-02-01&rft.volume=41&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Erosive esophagitis and nonerosive reflux disease (NERD): comparison of epidemiologic, physiologic, and therapeutic characteristics. AN - 85389674; pmid-17245209 AB - Nonerosive reflux disease (NERD) and erosive esophagitis are the main presentations of gastroesophageal reflux disease. However, NERD is the most common presentation of gastroesophageal reflux disease in community-based patients. Patients with NERD differ in demographic characteristics from patients with erosive esophagitis, primarily in sex distribution, weight/body mass index, and prevalence of hiatal hernia. Physiologically, patients with NERD tend to have normal lower esophageal sphincter resting pressure, minimal esophageal body motility abnormalities, low esophageal acid exposure profile and minimal nighttime esophageal acid exposure. Patients with NERD have a lower symptom response rate to proton pump inhibitor once daily than patients with erosive esophagitis. Additionally, NERD patients demonstrate a longer lag-time for symptom resolution and lack of difference in symptom response rate between half to full dose proton pump inhibitor as compared with patients with erosive esophagitis. JF - Journal of clinical gastroenterology AU - Fass, Ronnie AD - The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723-0001, USA. Ronnie.Fass@med.VA.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 131 EP - 137 VL - 41 IS - 2 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Esophagitis, Peptic: epidemiology KW - Esophagitis, Peptic: pathology KW - Esophagitis, Peptic: physiopathology KW - Esophagitis, Peptic: therapy KW - Gastroesophageal Reflux: epidemiology KW - Gastroesophageal Reflux: pathology KW - Gastroesophageal Reflux: physiopathology KW - Gastroesophageal Reflux: therapy KW - Humans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85389674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Erosive+esophagitis+and+nonerosive+reflux+disease+%28NERD%29%3A+comparison+of+epidemiologic%2C+physiologic%2C+and+therapeutic+characteristics.&rft.au=Fass%2C+Ronnie&rft.aulast=Fass&rft.aufirst=Ronnie&rft.date=2007-02-01&rft.volume=41&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - A phase II study of paclitaxel, carboplatin, and radiation with or without surgery for esophageal cancer. AN - 70340590; 17410032 AB - Cisplatin-based chemoradiotherapy (CRT) has been a standard treatment for patients with locally advanced esophageal cancer. However, cisplatin is associated with significant toxicity. We conducted a phase II clinical trial of concurrent paclitaxel, carboplatin, and radiation with or without surgery as an alternative to the standard cisplatin-based CRT for localized and metastatic esophageal cancer. Fifty patients with esophageal cancer were enrolled: 16 patients with stage II, eight patients with stage III, and 26 patients with stage IV disease. Two thirds (67%) of patients had adenocarcinoma and one third (33%) with squamous histology. Patients with resectable disease were treated with paclitaxel 30 mg/m, twice weekly for 10 doses, carboplatin AUC (area under the curve) 1.5 weekly for five doses; and concurrent radiation, 1.8 Gy/day, for a total of 45 Gy, followed by esophagectomy. Without surgery, patients received an additional dose each of paclitaxel and carboplatin with concurrent radiation for a total of 50.4 Gy, followed by two consolidation cycles of paclitaxel (200 mg/m) and carboplatin (AUC 6). During CRT, common stage III/IV toxicities included nausea/emesis (19%), esophagitis (9%), and neutropenia (4%). For consolidation chemotherapy, neutropenia (23%), neuropathy (8%) and nausea/emesis (4%) were the most common stage III/IV side effects. After CRT, 26% had a complete response, 17% had a partial response, and 41% had stable disease. Ninety-one percent of patients had clinical improvement of dysphagia. With a median follow-up of 32 months, the median survival was 12 months for patients with metastatic disease, 44 months for localized disease treated with esophagectomy, and >44 months for localized disease treated with definitive CRT. The regimen of paclitaxel, carboplatin, and radiation with or without surgery is well tolerated with promising efficacy for patients with esophageal cancer. JF - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer AU - Wang, Henry AU - Ryu, Janice AU - Gandara, David AU - Bold, Richard J AU - Urayama, Shiro AU - Tanaka, Michael AU - Goldberg, Zelanna AU - Follette, David AU - Narayan, Samir AU - Lau, Derick AD - Davis Cancer Center, University of California and Veterans Administration, Northern California Health System, Sacramento, CA 95817, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 153 EP - 157 VL - 2 IS - 2 KW - Carboplatin KW - BG3F62OND5 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Combined Modality Therapy KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Carboplatin -- administration & dosage KW - Male KW - Female KW - Esophageal Neoplasms -- surgery KW - Esophageal Neoplasms -- radiotherapy KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Esophageal Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70340590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.atitle=A+phase+II+study+of+paclitaxel%2C+carboplatin%2C+and+radiation+with+or+without+surgery+for+esophageal+cancer.&rft.au=Wang%2C+Henry%3BRyu%2C+Janice%3BGandara%2C+David%3BBold%2C+Richard+J%3BUrayama%2C+Shiro%3BTanaka%2C+Michael%3BGoldberg%2C+Zelanna%3BFollette%2C+David%3BNarayan%2C+Samir%3BLau%2C+Derick&rft.aulast=Wang&rft.aufirst=Henry&rft.date=2007-02-01&rft.volume=2&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.issn=1556-1380&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-17 N1 - Date created - 2007-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug-induced movement disorders in older adults: an overview for clinical practitioners. AN - 70282825; 17367248 AB - To provide an overview of some of the most common drug-induced movement disorders (DIMD) seen in the elderly by the primary care clinician. The epidemiology, clinical presentation, differential diagnosis, treatment, risk factors, and preventive measures are presented for each DIMD. Medical literature and research article search utilizing PubMed (National Library of Medicine), Psych INFO (American Psychological Association), CINAHL Database (CINAHL Information Systems), the Library of Congress Catalogue, and the Internet. Reviews and articles from 1954 to 2005 concerning various movement disorders associated with medication in older adults. DATA EXTRACTIONS: Data on movement disorders associated with medications ranging from possible or controversial to well-established. With the aging of populations in the United States and other countries, the use of medications with potential risk of precipitating movement disorders is increasing. The majority of these iatrogenic problems will be first seen in the geriatric patient in various clinical settings, typically in a primary care setting. To a large extent they will be observed in patients with mild cognitive impairment or dementia having impaired recall and reduced capacity to participate in the diagnostic interview. The challenge to clinicians is complicated by the sizable number of medications that may be involved. JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists AU - Detweiler, Mark B AU - Kalafat, Naciye AU - Kim, Kye Y AD - Veterans Affairs Medical Center, Salem, Virginia, USA. Mark.Detweiler1@med.va.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 149 EP - 165 VL - 22 IS - 2 SN - 0888-5109, 0888-5109 KW - Index Medicus KW - Risk Factors KW - Humans KW - Practice Guidelines as Topic KW - Aged KW - Drug-Related Side Effects and Adverse Reactions KW - Movement Disorders -- etiology KW - Movement Disorders -- diagnosis KW - Movement Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70282825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.atitle=Drug-induced+movement+disorders+in+older+adults%3A+an+overview+for+clinical+practitioners.&rft.au=Detweiler%2C+Mark+B%3BKalafat%2C+Naciye%3BKim%2C+Kye+Y&rft.aulast=Detweiler&rft.aufirst=Mark&rft.date=2007-02-01&rft.volume=22&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.issn=08885109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-05 N1 - Date created - 2007-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A multivariate fall risk assessment model for VHA nursing homes using the minimum data set. AN - 68994335; 17289542 AB - The purpose of this study was to develop a multivariate fall risk assessment model beyond the current fall Resident Assessment Protocol (RAP) triggers for nursing home residents using the Minimum Data Set (MDS). Retrospective, clustered secondary data analysis. National Veterans Health Administration (VHA) long-term care nursing homes (N = 136). The study population consisted of 6577 national VHA nursing home residents who had an annual assessment during FY 2005, identified from the MDS, as well as an earlier annual or admission assessment within a 1-year look-back period. A dichotomous multivariate model of nursing home residents coded with a fall on selected fall risk characteristics from the MDS, estimated with general estimation equations (GEE). There were 17 170 assessments corresponding to 6577 long-term care nursing home residents. The increased odds ratio (OR) of being classified as a faller relative to the omitted "dependent" category of activities of daily living (ADL) ranged from OR = 1.35 for "limited" ADL category up to OR = 1.57 for "extensive-2" ADL (P < .0001). Unsteady gait more than doubles the odds of being a faller (OR = 2.63, P < .0001). The use of assistive devices such as canes, walkers, or crutches, or the use of wheelchairs increases the odds of being a faller (OR = 1.17, P < .0005) or (OR = 1.19, P < .0002), respectively. Foot problems may also increase the odds of being a faller (OR = 1.26, P < .0016). Alzheimer's or other dementias also increase the odds of being classified as a faller (OR = 1.18, P < .0219) or (OR=1.22, P < .0001), respectively. In addition, anger (OR = 1.19, P < .0065); wandering (OR = 1.53, P < .0001); or use of antipsychotic medications (OR = 1.15, P < .0039), antianxiety medications (OR = 1.13, P < .0323), or antidepressant medications (OR = 1.39, P < .0001) was also associated with the odds of being a faller. This national study in one of the largest managed healthcare systems in the United States has empirically confirmed the relative importance of certain risk factors for falls in long-term care settings. The model incorporated an ADL index and adjusted for case mix by including only long-term care nursing home residents. The study offers clinicians practical estimates by combining multiple univariate MDS elements in an empirically based, multivariate fall risk assessment model. JF - Journal of the American Medical Directors Association AU - French, Dustin D AU - Werner, Dennis C AU - Campbell, Robert R AU - Powell-Cope, Gail M AU - Nelson, Audrey L AU - Rubenstein, Laurence Z AU - Bulat, Tatjana AU - Spehar, Andrea M AD - VISN-8 Patient Safety Center of Inquiry, James A. Haley VAMC, Tampa, FL 33612, USA. Dustin.French@va.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 115 EP - 122 VL - 8 IS - 2 SN - 1525-8610, 1525-8610 KW - Index Medicus KW - United States KW - Mobility Limitation KW - Odds Ratio KW - Data Collection -- methods KW - Patient Admission KW - Drug-Related Side Effects and Adverse Reactions KW - Humans KW - Retrospective Studies KW - Dementia -- complications KW - Activities of Daily Living KW - Aged KW - Orthopedic Equipment KW - United States Department of Veterans Affairs KW - Risk Factors KW - Confusion -- complications KW - Data Interpretation, Statistical KW - Long-Term Care KW - Cluster Analysis KW - Geriatric Assessment -- methods KW - Accidental Falls -- statistics & numerical data KW - Accidental Falls -- prevention & control KW - Models, Statistical KW - Risk Assessment -- methods KW - Nursing Homes KW - Multivariate Analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68994335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Globe+and+Mail&rft.atitle=Heroin+substitute+offers+hope+to+addicts&rft.au=Bula%2C+Frances&rft.aulast=Bula&rft.aufirst=Frances&rft.date=2013-08-30&rft.volume=&rft.issue=&rft.spage=S.1&rft.isbn=&rft.btitle=&rft.title=The+Globe+and+Mail&rft.issn=03190714&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-04 N1 - Date created - 2007-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - How are substance use disorders addressed in VA psychiatric and primary care settings? Results of a national survey. AN - 68994040; 17287386 AB - This study examined interventions for substance use disorders within the Department of Veterans Affairs (VA) psychiatric and primary care settings. National random samples of 83 VA psychiatry program directors and 102 primary care practitioners were surveyed by telephone. The survey assessed screening practices to detect substance use disorders, protocols for treating patients with substance use disorders, and available treatments for substance use disorders. Respondents reported extensive contact with patients with substance use problems. However, a majority reported being ill equipped to treat substance use disorders themselves; they usually referred such patients to specialty substance use disorder treatment programs. Offering fewer specialty substance use disorder services within the VA may be problematic: providers can refer patients to specialty programs only if such programs exist. Caring for veterans with substance use disorders may require increasing the capacity of and establishing new specialty programs or expanding the ability of psychiatric programs and primary care practitioners to provide such care. JF - Psychiatric services (Washington, D.C.) AU - Tracy, Stephen W AU - Trafton, Jodie A AU - Weingardt, Kenneth R AU - Aton, Eangelica G AU - Humphreys, Keith AD - Program Evaluation and Resource Center, Department of Veterans Affairs Palo Alto Health Care System, 795 Willow Road (MPD-152), Menlo Park, CA 94025, USA. stephen.tracy@va.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 266 EP - 269 VL - 58 IS - 2 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - United States KW - Referral and Consultation -- statistics & numerical data KW - Mass Screening -- statistics & numerical data KW - Health Services Needs and Demand -- statistics & numerical data KW - Humans KW - Health Services Research KW - Alcoholism -- rehabilitation KW - Veterans -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Veterans -- psychology KW - Primary Health Care KW - Substance-Related Disorders -- rehabilitation KW - Military Psychiatry KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68994040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=How+are+substance+use+disorders+addressed+in+VA+psychiatric+and+primary+care+settings%3F+Results+of+a+national+survey.&rft.au=Tracy%2C+Stephen+W%3BTrafton%2C+Jodie+A%3BWeingardt%2C+Kenneth+R%3BAton%2C+Eangelica+G%3BHumphreys%2C+Keith&rft.aulast=Tracy&rft.aufirst=Stephen&rft.date=2007-02-01&rft.volume=58&rft.issue=2&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2007-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolic syndrome: pathogenesis, medical care and dental implications. AN - 68971219; 17272372 AB - The dental literature contains little information about metabolic syndrome (MetS) and its dental implications. The authors conducted a MEDLINE search for the period 2000 through 2005, using the term "metabolic syndrome" to define its pathophysiology, medical treatment and dental implications. MetS is the co-occurrence of abdominal obesity, hyper-triglyceridemia, reduced high-density lipoprotein cholesterol levels, hypertension and impaired fasting glucose, which results from consumption of a high-calorie diet and decreased levels of physical activity superimposed on the appropriate genetic setting. Components of MetS synergistically promote the development of atherosclerosis, resulting in myocardial infarction and stroke. Deteriorating oral health status is associated with worsening of the atherogenic profile. Tooth loss often results in chewing difficulties because of inadequate occlusive surfaces and may lead to alterations in food selection and dietary quality. This, in turn, adversely affects body composition and nutritional status, both of which are related to vascular health. Dentists should develop treatment plans that preserve and restore the dentition, thus ensuring maximum masticatory efficiency and affording patients the optimum opportunity to consume food that will not foster atherogenesis. JF - Journal of the American Dental Association (1939) AU - Friedlander, Arthur H AU - Weinreb, Jane AU - Friedlander, Ida AU - Yagiela, John A AD - Graduate Medical Education, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA. arthur.friedlander@med.va.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 179 EP - 87; quiz 248 VL - 138 IS - 2 SN - 0002-8177, 0002-8177 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Anticholesteremic Agents KW - Appetite Depressants KW - Fatty Acids KW - Dentistry KW - Index Medicus KW - Obesity -- therapy KW - Diet Therapy KW - Drug Interactions KW - Appetite Depressants -- adverse effects KW - Hypertension -- physiopathology KW - Humans KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Mouth Diseases -- chemically induced KW - Insulin Resistance -- physiology KW - Fatty Acids -- metabolism KW - Abdominal Fat -- metabolism KW - Anticholesteremic Agents -- adverse effects KW - United States -- epidemiology KW - Fatty Acids -- blood KW - Metabolic Syndrome X -- therapy KW - Metabolic Syndrome X -- etiology KW - Metabolic Syndrome X -- epidemiology KW - Dental Care for Chronically Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68971219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Metabolic+syndrome%3A+pathogenesis%2C+medical+care+and+dental+implications.&rft.au=Friedlander%2C+Arthur+H%3BWeinreb%2C+Jane%3BFriedlander%2C+Ida%3BYagiela%2C+John+A&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2007-02-01&rft.volume=138&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-27 N1 - Date created - 2007-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Dent Assoc. 2007 Jun;138(6):712, 714; author reply 714, 716 [17545256] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Etiologic factors of chronic constipation: review of the scientific evidence. AN - 68962321; 17219073 AB - Geriatric patient educational material and a general practice review suggest insufficient dietary fiber intake, inadequate fluid intake, decrease physical activity, side effects of drugs, hypothyroidism, sex hormones and colorectal cancer obstruction may play a role in the pathogenesis of constipation. A search of recent literature, however, reveals that there is a paucity of evidence-based publications that address the etiologic factors of chronic constipation. Much of current writings on the subject may be based primarily on myths handed down from one generation to the next. In the absence of well-designed studies, there do not appear to be sufficient evidence-based information to implicate the above as major etiologic factors in the development of chronic constipation. The etiological role of each of these factors in the development of chronic constipation deserves to be assessed by modern techniques and methodologies. Funding agencies including the government and industry sponsors should support the development of evidence-based data sets. The understanding of the etiology of chronic constipation is the foundation on which cost-effective management strategies are to be built. JF - Digestive diseases and sciences AU - Leung, Felix W AD - Division of Gastroenterology, Research and Medical Services, Sepulveda Ambulatory Care Center and Nursing Home, Sepulveda, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, 91343, USA. felix.leung@va.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 313 EP - 316 VL - 52 IS - 2 SN - 0163-2116, 0163-2116 KW - Gonadal Steroid Hormones KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Evidence-Based Medicine KW - Dehydration -- complications KW - Drug-Related Side Effects and Adverse Reactions KW - Humans KW - Dietary Fiber -- deficiency KW - Exercise KW - Hypothyroidism -- complications KW - Gonadal Steroid Hormones -- adverse effects KW - Diet -- adverse effects KW - Life Style KW - Neoplasms -- complications KW - Risk Factors KW - Treatment Outcome KW - Chronic Disease KW - Constipation -- etiology KW - Constipation -- therapy KW - Constipation -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68962321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Vancouver%27s+free-heroin+experiment+wins+praise%3A+%5BFINAL+C+Edition%5D&rft.au=Travis%2C+Heather&rft.aulast=Travis&rft.aufirst=Heather&rft.date=2006-05-01&rft.volume=&rft.issue=&rft.spage=B.1.Fro&rft.isbn=&rft.btitle=&rft.title=The+Vancouver+Sun&rft.issn=08321299&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-03 N1 - Date created - 2007-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reducing Drug Costs at a Veterans Affairs Hospital by Increasing Market-share of Generic Fluoxetine AN - 57229095; 200716824 AB - We previously showed that a multifaceted intervention designed to contain costs of prescribing selective serotonin reuptake inhibitors (SSRIs) at a Veterans Affairs hospital resulted in substantial projected savings. Intervention components included clinician education and pharmacy and computer information process changes. We now report on effects of altering the intervention to promote prescribing of generic fluoxetine. Over 30 months, fluoxetine's market-share increased from 12 to 32% of all SSRIs prescribed. A total of $2,500,000 in cost avoidance resulted from substituting generic for brand fluoxetine, and $600,000 resulted from increases in market-share of fluoxetine. The results highlight the robustness and flexibility of the intervention approach. Adapted from the source document. JF - Community Mental Health Journal AU - Dobscha, Steven K AU - Winterbottom, Lisa M AU - Snodgrass, LeAnn S AD - Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, P. 0. Box 1034 (P3MHDC), Portland, OR 97207, USA E-mail: steven.dobscha@med.va.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 75 EP - 84 PB - Springer, Dordrecht The Netherlands VL - 43 IS - 1 SN - 0010-3853, 0010-3853 KW - economics, pharmaceutical, antidepressive agents, decision support systems, clinical, drug utilization KW - Cost containment KW - Fluoxetine KW - Veterans KW - Health costs KW - Generic prescribing KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57229095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Reducing+Drug+Costs+at+a+Veterans+Affairs+Hospital+by+Increasing+Market-share+of+Generic+Fluoxetine&rft.au=Dobscha%2C+Steven+K%3BWinterbottom%2C+Lisa+M%3BSnodgrass%2C+LeAnn+S&rft.aulast=Dobscha&rft.aufirst=Steven&rft.date=2007-02-01&rft.volume=43&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-006-9062-7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-09-28 N1 - Last updated - 2016-09-27 N1 - CODEN - CMHJAY N1 - SubjectsTermNotLitGenreText - Veterans; Health costs; Fluoxetine; Generic prescribing; Cost containment DO - http://dx.doi.org/10.1007/s10597-006-9062-7 ER - TY - JOUR T1 - Validity Rates of the Personality Assessment Inventory and the Minnesota Multiphasic Personality Inventory-2 in a VA Medical Center Setting AN - 57221005; 200714900 AB - In this study, we compared protocol validity rates between the MMPI-2 (Butcher, Dahistrom, Graham, Tellegen, & Kaemmer, 1989) and the Personality Assessment Inventory (PAI, Morey, 1991) in a veteran population. Veterans (N = 472) were administered both instruments as part of routine psychological evaluations. Profile validity was based on previously published criteria. When applying primary validity indicators, inpatients produced significantly fewer invalid PAI profiles (37%) than MMPI-2 profiles (63%). We found similar results among outpatients for which we considered 47% of MMPI-2 profiles invalid compared to only 21% of PAI profiles. When applying both primary and supplementary validity indicators, both inpatients and outpatients continued to produce fewer invalid PAI profiles than MMPI-2 profiles. We discuss factors that may be related to the differences in validity rates. Adapted from the source document. JF - Journal of Personality Assessment AU - Braxton, Loretta E AU - Calhoun, Patrick S AU - Williams, John E AU - Boggs, Christina D AD - Mental Health Service Line (116B), VA Medical Center 508 Fulton Street, Durham, NC 265 E-mail: loretta.braxton@va.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 5 EP - 15 PB - Lawrence Erlbaum Associates, Mahwah NJ VL - 88 IS - 1 SN - 0022-3891, 0022-3891 KW - Veterans KW - Psychological assessment KW - Minnesota Multiphasic Personality Inventory-2 KW - Validity KW - Personality tests KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57221005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+Assessment&rft.atitle=Validity+Rates+of+the+Personality+Assessment+Inventory+and+the+Minnesota+Multiphasic+Personality+Inventory-2+in+a+VA+Medical+Center+Setting&rft.au=Braxton%2C+Loretta+E%3BCalhoun%2C+Patrick+S%3BWilliams%2C+John+E%3BBoggs%2C+Christina+D&rft.aulast=Braxton&rft.aufirst=Loretta&rft.date=2007-02-01&rft.volume=88&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+Assessment&rft.issn=00223891&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-08-28 N1 - Last updated - 2016-09-27 N1 - CODEN - JNPABU N1 - SubjectsTermNotLitGenreText - Minnesota Multiphasic Personality Inventory-2; Personality tests; Veterans; Validity; Psychological assessment ER - TY - JOUR T1 - Validity of the Personality Assessment Inventory Aggression Scales and Violence Potential Index in Veterans With PTSD AN - 57216636; 200715045 AB - In this study, we examined the validity of the Personality Assessment Inventory (PAI, Morey, 1991) Aggression (AGG) scales and Violence Potential index (VPI) in 399 male combat veterans presenting for formal evaluation of posttraumatic stress disorder (PTSD). The AGG scales exhibited convergence with other measures of hostility and violence and demonstrated discriminant validity with alternative constructs. When we examined reports of interpersonal violence in the past year, the AGG composite scale displayed substantial incremental validity over the effects of PTSD severity, demographics, a simple dichotomous question regarding violence in the past 30 days, and MMPI-2 (Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 1989) scales measuring aggression. The VPI, however, added no unique explanatory power over the AGG composite scale. Adapted from the source document. JF - Journal of Personality Assessment AU - Crawford, Eric F AU - Calhoun, Patrick S AU - Braxton, Loretta E AU - Beckham, Jean C AD - Mental Health Service Line (116B), VA Medical Center, 508 Fulton Street, Durham, NC 27705 E-mail: Patrick.cathoun2@va.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 90 EP - 98 PB - Lawrence Erlbaum Associates, Mahwah NJ VL - 88 IS - 1 SN - 0022-3891, 0022-3891 KW - Veterans KW - Psychological assessment KW - Posttraumatic stress disorder KW - Scales KW - Personality tests KW - Aggression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57216636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+Assessment&rft.atitle=Validity+of+the+Personality+Assessment+Inventory+Aggression+Scales+and+Violence+Potential+Index+in+Veterans+With+PTSD&rft.au=Crawford%2C+Eric+F%3BCalhoun%2C+Patrick+S%3BBraxton%2C+Loretta+E%3BBeckham%2C+Jean+C&rft.aulast=Crawford&rft.aufirst=Eric&rft.date=2007-02-01&rft.volume=88&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+Assessment&rft.issn=00223891&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-08-28 N1 - Last updated - 2016-09-27 N1 - CODEN - JNPABU N1 - SubjectsTermNotLitGenreText - Psychological assessment; Personality tests; Posttraumatic stress disorder; Aggression; Veterans; Scales ER - TY - JOUR T1 - African American Veteran's Experiences with Mobile Geriatric Care AN - 57196185; 200714104 AB - To explore perspectives concerning use of a mobile geriatrics unit (MGU) by underserved populations in low-income urban neighborhoods, we recruited 18 elderly African American patients & engaged them in in-depth semistructured interviews. Using grounded theory techniques of constant comparative analysis, we found that most patients learned about the MGU from community members & initially visited it to determine whether it would be worth using in the future. In describing their MGU experiences, patients tended to focus on three main factors: quality of care, accessibility of services, & ambience of the care setting. They reported that the MGU allowed them to have their health conditions & medications monitored regularly & functioned as a central link to the larger Veterans Affairs health care system. The findings suggest that using MGUs is an acceptable & effective way to help medically underserved populations receive primary medical care & referrals to specialty care. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Rodriguez, Keri L AU - Appelt, Cathleen J AU - Young, Amanda J AU - Fox, Andrea R AD - Center Health Equity Research & Promotion, VA Pittsburgh Healthcare System, PA Keri.rodriguez@va.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 44 EP - 53 PB - John Hopkins University Press, Baltimore MD VL - 18 IS - 1 SN - 1049-2089, 1049-2089 KW - Veterans, mobile health unit, geriatrics, African Americans, qualitative research KW - Veterans KW - Elderly people KW - Black American people KW - Mobile services KW - Health services KW - Qualitative research KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57196185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=African+American+Veteran%27s+Experiences+with+Mobile+Geriatric+Care&rft.au=Rodriguez%2C+Keri+L%3BAppelt%2C+Cathleen+J%3BYoung%2C+Amanda+J%3BFox%2C+Andrea+R&rft.aulast=Rodriguez&rft.aufirst=Keri&rft.date=2007-02-01&rft.volume=18&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-31 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Veterans; Qualitative research; Black American people; Elderly people; Mobile services; Health services ER - TY - JOUR T1 - Hearing Handicap among Adult Residents of an Urban Homeless Shelter AN - 57192832; 200714142 AB - This retrospective study was undertaken to identify the prevalence of hearing loss in the homeless population & its implications for vocational rehabilitation. Audiometric threshold data for adult residents of an urban homeless shelter were collected & reported. Subjects with hearing loss were identified & defined by their binaural high-frequency pure tone average (B-HFPTA). Those subjects were assigned a predicted Hearing Handicap Inventory for Adults-Screener (HHIA-S) score. Their HHIA-S scores, in turn, were used to predict hearing handicap & hearing aid candidacy. Significant hearing handicap was predicted for 35.6% of subjects; 10.6% were identified as hearing aid candidates. These findings have implications for vocational rehabilitation that have not been previously addressed. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Saccone, Patricia A AU - Steiger, James R AD - Dept Veterans Affairs Medical Center, West Palm Beach, FL patricia.saccone@va.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 161 EP - 172 PB - John Hopkins University Press, Baltimore MD VL - 18 IS - 1 SN - 1049-2089, 1049-2089 KW - Homelessness, hearing loss, hearing handicap KW - Vocational rehabilitation KW - Sheltered accommodation KW - Homeless people KW - Hearing impairment KW - Urban areas KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57192832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Hearing+Handicap+among+Adult+Residents+of+an+Urban+Homeless+Shelter&rft.au=Saccone%2C+Patricia+A%3BSteiger%2C+James+R&rft.aulast=Saccone&rft.aufirst=Patricia&rft.date=2007-02-01&rft.volume=18&rft.issue=1&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-31 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Homeless people; Sheltered accommodation; Hearing impairment; Vocational rehabilitation; Urban areas ER - TY - JOUR T1 - Computerized tomography (CT)-guided aspiration of abscesses: Outcome of therapy at a tertiary care hospital AN - 21349554; 7585244 AB - Objective To review the experience with percutaneous aspiration of abscesses at a general, tertiary care hospital from 2000 to 2005. Methods Computerized medical records of 90 patients who underwent radiologically guided drainage of 92 fluid collections were reviewed for demographic data, co-morbid conditions, location, radiographic imaging characteristics and culture results and to determine the long-term outcome of the procedure. Results Sixty-seven of 92 (73%) abscesses were cured without the need for open surgical drainage; 44 were cured within 14 days, and 23 had delayed resolution requiring prolonged antibiotics and/or a second drainage. Of the abscesses 85% were drained using a catheter in situ, the remaining aspirated using a needle. Twenty-five (27%) of the 92 abscesses failed percutaneous drainage, requiring open surgical drainage or lead to sepsis and death. Neither co-morbid conditions nor the location of abscesses affected the outcome of drainage. Patients who had sterile cultures of aspirated material after receiving antibiotics prior to the procedure had a significantly higher cure rate than otherwise (P<0.05). Catheter drainage was associated with a significantly higher cure rate than was needle aspiration (P<0.05). Conclusion Percutaneous drainage, along with appropriate antibiotics, is an effective approach to treat deep abscesses. Drainage, itself, is the major determinant of outcome, rather than the location, characteristics of the abscess or condition of the patient prior to the procedure. JF - Journal of Infection AU - Mehendiratta, Vaibhav AU - McCarty, Brandon Chase AU - Gomez, Luis AU - Graviss, Edward A AU - Musher, Daniel M AD - Department of Medicine/Infectious Diseases Section, Michael E. DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA, daniel.musher@med.va.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 122 EP - 128 PB - W.B. Saunders Co. Ltd., 32 Jamestown Rd London NW1 7BY UK, [URL:http://www.harcourt-international.com] VL - 54 IS - 2 SN - 0163-4453, 0163-4453 KW - Microbiology Abstracts B: Bacteriology KW - CT-guided KW - Aspiration KW - Abscesses KW - Outcome of therapy KW - Demography KW - Sepsis KW - Data processing KW - medical records KW - Drainage KW - Computed tomography KW - Catheters KW - Antibiotics KW - imaging KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21349554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infection&rft.atitle=Computerized+tomography+%28CT%29-guided+aspiration+of+abscesses%3A+Outcome+of+therapy+at+a+tertiary+care+hospital&rft.au=Mehendiratta%2C+Vaibhav%3BMcCarty%2C+Brandon+Chase%3BGomez%2C+Luis%3BGraviss%2C+Edward+A%3BMusher%2C+Daniel+M&rft.aulast=Mehendiratta&rft.aufirst=Vaibhav&rft.date=2007-02-01&rft.volume=54&rft.issue=2&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infection&rft.issn=01634453&rft_id=info:doi/10.1016%2Fj.jinf.2006.03.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Demography; Sepsis; Data processing; medical records; Drainage; Computed tomography; Catheters; Antibiotics; Abscesses; imaging; Hospitals DO - http://dx.doi.org/10.1016/j.jinf.2006.03.004 ER - TY - JOUR T1 - Genetic analysis of mechanisms of multidrug resistance in a clinical isolate of Bacteroides fragilis AN - 20445994; 9125327 AB - AbstractThis study investigated the mechanisms of multidrug resistance (MDR) in an isolate of Bacteroides fragilis (WI1) from a patient with anaerobic sepsis. The MDR of WI1 affected susceptibility to beta -lactams, clindamycin, fluoroquinolones, metronidazole and tetracycline. In addition to its 5.31-Mb chromosome, WI1 possessed two low-copy-number plasmids, pHagl (5.6kb) and pHag2 (9.9kb), that were absent from B.fragilis NCTC 9343. Restriction digestion with EcoRV, HindIII and SstI, combined with DNA sequencing, revealed that pHAG2 contained a tet(Q) gene at base position 3689 that resided on the conjugative transposon CTn341. Genes cfiA (encoding a metallo- beta -lactamase) and erm(F) (encoding a macrolide-lincosamide-streptogramin B resistance determinant) were also found in WI1, but were absent from B.fragilis NCTC9343. Nitrocefin hydrolysis revealed that WI1 had high beta -lactamase activity. Sequencing of the gyrA quinolone resistance-determining region revealed a mutation causing a Ser82 arrow right Phe substitution, and comparative quantitative real-time RT-PCR revealed that the cfiA, erm(F) and tet(Q) genes were all expressed in WI1. In addition, the resistance-nodulation-division efflux pump genes bmeB9 and bmeB15 were significantly over-expressed (12.30 plus or minus 0.42-fold and 3541.1 plus or minus 95.4-fold, respectively), and the efflux pump inhibitors carbonyl cyanide m-chlorophenylhydrazone and reserpine significantly increased the susceptibility of the isolate to several unrelated antibiotics (p<0.005). These data suggested that WI1 was highly multidrug-resistant because of the additive effects of chromosome- and plasmid-encoded resistance determinants. JF - Clinical Microbiology and Infection AU - Pumbwe, L AU - Wareham, D W AU - Aduse-Opoku, J AU - Brazier, J S AU - Wexler, H M AD - 1Greater Los Angeles Veterans Administration Healthcare Systems, hwexler@ucla.edu Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 183 EP - 189 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 13 IS - 2 SN - 1198-743X, 1198-743X KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Bacteroides fragilis KW - cross-resistance KW - efflux pumps KW - multidrug resistance KW - plasmid KW - susceptibility KW - Metronidazole KW - Clindamycin KW - Drug resistance KW - Quinolones KW - Genetic analysis KW - Antibiotics KW - Tetracyclines KW - Transposons KW - DNA sequencing KW - Chromosomes KW - Cyanide KW - Polymerase chain reaction KW - Clinical isolates KW - Data processing KW - beta -Lactamase KW - Metallo- beta -lactamase KW - Fluoroquinolones KW - Reserpine KW - Plasmids KW - Hydrolysis KW - Sepsis KW - beta -Lactam antibiotics KW - Multidrug resistance KW - Mutation KW - carbonyls KW - G 07880:Human Genetics KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20445994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+and+Infection&rft.atitle=Genetic+analysis+of+mechanisms+of+multidrug+resistance+in+a+clinical+isolate+of+Bacteroides+fragilis&rft.au=Pumbwe%2C+L%3BWareham%2C+D+W%3BAduse-Opoku%2C+J%3BBrazier%2C+J+S%3BWexler%2C+H+M&rft.aulast=Pumbwe&rft.aufirst=L&rft.date=2007-02-01&rft.volume=13&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+and+Infection&rft.issn=1198743X&rft_id=info:doi/10.1111%2Fj.1469-0691.2006.01620.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Metronidazole; Clindamycin; Drug resistance; Genetic analysis; Quinolones; Antibiotics; Tetracyclines; Transposons; Chromosomes; DNA sequencing; Cyanide; Polymerase chain reaction; Clinical isolates; Metallo- beta -lactamase; beta -Lactamase; Data processing; Reserpine; Fluoroquinolones; Plasmids; Hydrolysis; Sepsis; beta -Lactam antibiotics; Multidrug resistance; carbonyls; Mutation; Bacteroides fragilis DO - http://dx.doi.org/10.1111/j.1469-0691.2006.01620.x ER - TY - JOUR T1 - Topical Administration of Nepafenac Inhibits Diabetes-Induced Retinal Microvascular Disease and Underlying Abnormalities of Retinal Metabolism and Physiology AN - 20129880; 7251841 AB - Pharmacologic treatment of diabetic retinopathy via eyedrops could have advantages but has not been successful to date. We explored the effect of topical Nepafenac, an anti-inflammatory drug known to reach the retina when administered via eyedrops, on the development of early stages of diabetic retinopathy and on metabolic and physiologic abnormalities that contribute to the retinal disease. Streptozotocin-induced diabetic rats were assigned to three groups (0.3% Nepafenac eyedrops, vehicle eyedrops, and untreated control) for comparison to age-matched nondiabetic control animals. Eyedrops were administered in both eyes four times per day for 2 and 9 months. At 2 months of diabetes, insulin-deficient diabetic control rats exhibited significant increases in retinal prostaglandin E sub(2), superoxide, vascular endothelial growth factor (VEGF), nitric oxide (NO), cyclooxygenase-2, and leukostasis within retinal microvessels. All of these abnormalities except NO and VEGF were significantly inhibited by Nepafenac. At 9 months of diabetes, a significant increase in the number of transferase-mediated dUTP nick-end labeling-positive capillary cells, acellular capillaries, and pericyte ghosts were measured in control diabetic rats versus nondiabetic controls, and topical Nepafenac significantly inhibited all of these abnormalities (all P < 0.05). Diabetes-induced activation of caspase-3 and -6 in retina was partially inhibited by Nepafenac (all P < 0.05). Oscillatory potential latency was the only abnormality of retinal function reproducibly detected in these diabetic animals, and Nepafenac significantly inhibited this defect (P < 0.05). Nepafenac did not have a significant effect on diabetes-induced loss of cells in the ganglion cell layer or in corneal protease activity. Topical ocular administration of Nepafenac achieved sufficient drug delivery to the retina and diabetes-induced alterations in retinal vascular metabolism, function, and morphology were inhibited. In contrast, little or no effect was observed on diabetes-induced alterations in retinal ganglion cell survival. Local inhibition of inflammatory pathways in the eye offers a novel therapeutic approach toward inhibiting the development of lesions of diabetic retinopathy. JF - Diabetes AU - Kern, Timothy S AU - Miller, Casey M AU - Du, Yunpeng AU - Zheng, Ling AU - Mohr, Susanne AU - Ball, Sherry L AU - Kim, M AU - Jamison, Jeffrey A AU - Bingaman, David P AD - Case Western Reserve University, Cleveland, Ohio. Retina Discovery Unit, Alcon Research, Health Science Center, University North Texas, Ft. Worth, Texas. Cleveland Veterans Administration Medical Center Research Service, Cleveland, Ohio. Health Science Center, University of North Texas, Fort Worth, Texas Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 373 EP - 379 PB - American Diabetes Association, 1701 N. Beauregard St. Alexandria VA 22311 USA, [mailto:customerservice@diabetes.org], [URL:http://www.diabetes.org] VL - 56 IS - 2 SN - 0012-1797, 0012-1797 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Cell survival KW - Vascular endothelial growth factor KW - Cyclooxygenase-2 KW - Microvasculature KW - Drug delivery KW - Eye KW - Retina KW - Retinal ganglion cells KW - pericytes KW - Developmental stages KW - Prostaglandin E2 KW - Inflammation KW - Diabetes mellitus KW - Cornea KW - Retinopathy KW - Superoxide KW - Caspase-3 KW - Nitric oxide KW - Proteinase KW - Nepafenac KW - Antiinflammatory agents KW - Metabolism KW - N3 11029:Neurophysiology & biophysics KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20129880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes&rft.atitle=Topical+Administration+of+Nepafenac+Inhibits+Diabetes-Induced+Retinal+Microvascular+Disease+and+Underlying+Abnormalities+of+Retinal+Metabolism+and+Physiology&rft.au=Kern%2C+Timothy+S%3BMiller%2C+Casey+M%3BDu%2C+Yunpeng%3BZheng%2C+Ling%3BMohr%2C+Susanne%3BBall%2C+Sherry+L%3BKim%2C+M%3BJamison%2C+Jeffrey+A%3BBingaman%2C+David+P&rft.aulast=Kern&rft.aufirst=Timothy&rft.date=2007-02-01&rft.volume=56&rft.issue=2&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Diabetes&rft.issn=00121797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Vascular endothelial growth factor; Cell survival; Drug delivery; Microvasculature; Retina; Eye; Retinal ganglion cells; Developmental stages; pericytes; Prostaglandin E2; Inflammation; Diabetes mellitus; Cornea; Superoxide; Retinopathy; Caspase-3; Proteinase; Nitric oxide; Nepafenac; Antiinflammatory agents; Metabolism ER - TY - JOUR T1 - Cathepsin Cs Are Key for the Intracellular Survival of the Protozoan Parasite, Toxoplasma gondii AN - 19787214; 7288467 AB - Cysteine proteases play key roles in apicomplexan invasion, organellar biogenesis, and intracellular survival. We have now characterized five genes encoding papain family cathepsins from Toxoplasma gondii, including three cathepsin Cs, one cathepsin B, and one cathepsin L. Unlike endopeptidases cathepsin B and L, T. gondii cathepsin Cs are exopeptidases and remove dipeptides from unblocked N-terminal substrates of proteins or peptides. TgCPC1 was the most highly expressed cathepsin mRNA in tachyzoites (by real-time PCR), but three cathepsins, TgCPC1, TgCPC2, and TgCPB, were undetectable in in vivo bradyzoites. The specific cathepsin C inhibitor, Gly-Phe-dimethylketone, selectively inhibited the TgCPCs activity, reducing parasite intracellular growth and proliferation. The targeted disruption of TgCPC1 does not affect the invasion and growth of tachyzoites as TgCPC2 is then up-regulated and may substitute for TgCPC1. TgCPC1 and TgCPC2 localize to constitutive secretory vesicles of tachyzoites, the dense granules. T. gondii cathepsin Cs are required for peptide degradation in the parasitophorous vacuole as the degradation of the marker protein, Escherichia coli beta -lactamase, secreted into the parasitophorous vacuole of transgenic tachyzoites was completely inhibited by the cathepsin C inhibitor. Cathepsin C inhibitors also limited the in vivo infection of T. gondii in the chick embryo model of toxoplasmosis. Thus, cathepsin Cs are critical to T. gondii growth and differentiation, and their unique specificities could be exploited to develop novel chemotherapeutic agents. JF - Journal of Biological Chemistry AU - Que, Xuchu AU - Engel, Juan C AU - Ferguson, David AU - Wunderlich, Annette AU - Tomavo, Stanislas AU - Reed, Sharon L AD - Departments of Pathology and Medicine, University of California, San Diego, California 92103-8416, the Department of Pathology, University of California, San Francisco, Veterans Administration Medical Center, San Francisco, California 94121, the Nuffield Department of Pathology, Oxford University, Oxford OX3 9DU, United Kingdom, and the Equipe de Parasitologie Moleculaire, Unite de Glycobiologie Structurale et Fonctionnelle (UGSF), CNRS UMR 8576, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq Cedex, France Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 4994 EP - 5003 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 7 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Granules KW - Parasites KW - Papain KW - Chemotherapy KW - Cathepsin B KW - Survival KW - Infection KW - Models KW - Differentiation KW - Secretory vesicles KW - Escherichia coli KW - Polymerase chain reaction KW - cathepsins KW - Cysteine proteinase KW - Dipeptidyl-peptidase I KW - beta -Lactamase KW - bradyzoites KW - Toxoplasmosis KW - mRNA KW - parasitophorous vacuole KW - Cathepsin L KW - Toxoplasma gondii KW - tachyzoites KW - Evolution KW - endopeptidase KW - J 02410:Animal Diseases KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19787214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Cathepsin+Cs+Are+Key+for+the+Intracellular+Survival+of+the+Protozoan+Parasite%2C+Toxoplasma+gondii&rft.au=Que%2C+Xuchu%3BEngel%2C+Juan+C%3BFerguson%2C+David%3BWunderlich%2C+Annette%3BTomavo%2C+Stanislas%3BReed%2C+Sharon+L&rft.aulast=Que&rft.aufirst=Xuchu&rft.date=2007-02-01&rft.volume=282&rft.issue=7&rft.spage=4994&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Granules; Dipeptidyl-peptidase I; Parasites; beta -Lactamase; Chemotherapy; Papain; bradyzoites; Cathepsin B; Survival; Infection; Toxoplasmosis; Models; mRNA; parasitophorous vacuole; Differentiation; Cathepsin L; Secretory vesicles; tachyzoites; Polymerase chain reaction; cathepsins; Evolution; endopeptidase; Cysteine proteinase; Toxoplasma gondii; Escherichia coli ER - TY - JOUR T1 - Development of a Flow Chart for Identification of Gram-Positive Anaerobic Cocci in the Clinical Laboratory AN - 19565589; 7288863 AB - Gram-positive anaerobic cocci (GPAC) are a heterogeneous group of organisms that are isolated from clinical specimens more often than any group of anaerobic bacteria except Bacteroides species, yet many strains are still difficult or impossible to identify in the diagnostic laboratory. In this study, a total of 124 strains, including 13 reference strains of GPAC species and 111 isolates that had been recovered from clinical specimens previously and identified by 16S rRNA gene sequencing, were subjected to biochemical characterization. Based on the results, a short biochemical scheme that involves the minimum essential biochemical tests for accurate identification of clinically important GPAC was developed. JF - Journal of Clinical Microbiology AU - Song, Yuli AU - Liu, Chengxu AU - Finegold, Sydney M AD - Research Service. Infectious Diseases Section, Veterans Administration Medical Center West Los Angeles. Department of Medicine. Department of Microbiology, Immunology, and Molecular Genetics, University of California-Los Angeles School of Medicine, Los Angeles, California Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 512 EP - 516 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 45 IS - 2 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Cocci KW - Bacteroides KW - Gram-positive bacteria KW - rRNA 16S KW - Anaerobic bacteria KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19565589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Development+of+a+Flow+Chart+for+Identification+of+Gram-Positive+Anaerobic+Cocci+in+the+Clinical+Laboratory&rft.au=Song%2C+Yuli%3BLiu%2C+Chengxu%3BFinegold%2C+Sydney+M&rft.aulast=Song&rft.aufirst=Yuli&rft.date=2007-02-01&rft.volume=45&rft.issue=2&rft.spage=512&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cocci; Gram-positive bacteria; rRNA 16S; Anaerobic bacteria; Bacteroides ER - TY - JOUR T1 - Improving emergency caesarean delivery response times at a rural community hospital AN - 19552380; 8748005 AB - Introduction: According to national organisations, obstetric services should be able to initiate a caesarean delivery within 30 minutes of the decision to operate. This is uniquely challenging in a small, rural hospital. In 2001, the authors' hospital was unable to meet this guideline reliably. This project demonstrates how we improved our emergency caesarean delivery response time. Methods: The caesarean delivery process was examined, project co-chairs were selected and key personnel were identified. Four working groups (doctors, nurses, anaesthesia, operating room personnel) were formed to analyse and improve component parts of the process. Over time, multiple small changes were made, initially by each working group and then by the entire caesarean delivery team. Decision-to-incision time was the main outcome measure. The authors also measured standard birth statistics and tracked the percentage of caesarean deliveries that were classified as an emergency. Results: Forty emergency caesarean deliveries occurred during the study. The mean decision-to-incision time dropped from 31 to 20 minutes and the treatment to goal ratio increased from 0.5 to 1.0. The percentage of caesarean deliveries that were classified as emergencies dropped significantly. There has been no change in the overall caesarean delivery rate or other markers of obstetric quality. Conclusions: A small, rural community hospital with limited resources can consistently meet the 30 minute decision-to-incision guideline for emergency caesarean delivery. JF - Quality & Safety in Health Care AU - Mooney, SE AU - Ogrinc, G AU - Steadman, W AD - 215 North Main Street, 11Q, White River Junction, VT 05009, USA, susan.mooney@med.va.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 VL - 16 IS - 1 SN - 1475-3898, 1475-3898 KW - Health & Safety Science Abstracts KW - surgery KW - Medical personnel KW - anesthesia KW - Health care KW - guidelines KW - nursing KW - Rural areas KW - Hospitals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19552380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quality+%26+Safety+in+Health+Care&rft.atitle=Improving+emergency+caesarean+delivery+response+times+at+a+rural+community+hospital&rft.au=Mooney%2C+SE%3BOgrinc%2C+G%3BSteadman%2C+W&rft.aulast=Mooney&rft.aufirst=SE&rft.date=2007-02-01&rft.volume=16&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Quality+%26+Safety+in+Health+Care&rft.issn=14753898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Hospitals; Rural areas; Medical personnel; guidelines; nursing; surgery; anesthesia; Health care ER - TY - JOUR T1 - IL-18 Is Induced and IL-18 Receptor alpha Plays a Critical Role in the Pathogenesis of Cigarette Smoke-Induced Pulmonary Emphysema and Inflammation AN - 19536890; 7253428 AB - Th1 inflammation and remodeling characterized by local tissue destruction coexist in pulmonary emphysema and other diseases. To test the hypothesis that IL-18 plays an important role in these responses, we characterized the regulation of IL-18 in lungs from cigarette smoke (CS) and room air-exposed mice and characterized the effects of CS in wild-type mice and mice with null mutations of IL-18R alpha (IL-18R alpha super(-/-)). CS was a potent stimulator and activator of IL-18 and caspases 1 and 11. In addition, although CS caused inflammation and emphysema in wild-type mice, both of these responses were significantly decreased in IL-18R alpha super(-/-) animals. CS also induced epithelial apoptosis, activated effector caspases and stimulated proteases and chemokines via IL-18R alpha -dependent pathways. Importantly, the levels of IL-18 and its targets, cathepsins S and B, were increased in pulmonary macrophages from smokers and patients with chronic obstructive lung disease. Elevated levels of circulating IL-18 were also seen in patients with chronic obstructive lung disease. These studies demonstrate that IL-18 and the IL-18 pathway are activated in CS-exposed mice and man. They also demonstrate, in a murine modeling system, that IL-18R signaling plays a critical role in the pathogenesis of CS-induced inflammation and emphysema. JF - Journal of Immunology AU - Kang, Min-Jong AU - Homer, Robert J AU - Gallo, Amy AU - Lee, Chun Geun AU - Crothers, Kristina A AU - Cho, Soo Jung AU - Rochester, Carolyn AU - Cain, Hilary AU - Chupp, Geoffrey AU - Yoon, Ho Joo AU - Elias, Jack A AD - Section of Pulmonary and Critical Care Medicine, Department of Pathology, and Department of Surgery, Yale University School of Medicine, New Haven, CT 06520. Department of Pathology and Laboratory Medicine Service, Veterans Administration-Connecticut Health Care System, West Haven, CT 06516. Division of Pulmonary Medicine, Department of Internal Medicine, Hanyang University Hospital, College of Medicine, Seoul, Korea Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 1948 EP - 1959 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 178 IS - 3 SN - 0022-1767, 0022-1767 KW - Toxicology Abstracts; Immunology Abstracts KW - Macrophages KW - Emphysema KW - Interleukin 18 receptors KW - Chemokines KW - Apoptosis KW - Helper cells KW - Cigarette smoke KW - Chronic obstructive pulmonary disease KW - Inflammation KW - Interleukin 18 KW - Lymphocytes T KW - Caspase-1 KW - Cathepsin S KW - Mutation KW - Signal transduction KW - X 24380:Social Poisons & Drug Abuse KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19536890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=IL-18+Is+Induced+and+IL-18+Receptor+alpha+Plays+a+Critical+Role+in+the+Pathogenesis+of+Cigarette+Smoke-Induced+Pulmonary+Emphysema+and+Inflammation&rft.au=Kang%2C+Min-Jong%3BHomer%2C+Robert+J%3BGallo%2C+Amy%3BLee%2C+Chun+Geun%3BCrothers%2C+Kristina+A%3BCho%2C+Soo+Jung%3BRochester%2C+Carolyn%3BCain%2C+Hilary%3BChupp%2C+Geoffrey%3BYoon%2C+Ho+Joo%3BElias%2C+Jack+A&rft.aulast=Kang&rft.aufirst=Min-Jong&rft.date=2007-02-01&rft.volume=178&rft.issue=3&rft.spage=1948&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Emphysema; Chemokines; Interleukin 18 receptors; Apoptosis; Helper cells; Cigarette smoke; Inflammation; Chronic obstructive pulmonary disease; Interleukin 18; Lymphocytes T; Cathepsin S; Caspase-1; Mutation; Signal transduction ER - TY - JOUR T1 - Increased hepatic telomerase activity in a rat model of iron overload: a role for altered thiol redox state? AN - 68378449; 17189828 AB - Telomeres are repeated sequences at chromosome ends that are incompletely replicated during mitosis. Telomere shortening caused by proliferation or oxidative damage culminates in replicative arrest and senescence, which may impair regeneration during chronic liver injury. Whereas the effects of experimental liver injury on telomeres have received little attention, prior studies suggest that telomerase, the enzyme complex that catalyzes the addition of telomeric repeats, is protective in some rodent liver injury models. Thus, the aim of this study was to determine the effects of iron overload on telomere length and telomerase activity in rat liver. Mean telomere lengths were similar in iron-loaded and control livers. However, telomerase activity was increased 3-fold by iron loading, with no change in levels of TERT mRNA or protein. Because thiol redox state has been shown to modulate telomerase activity in vitro, hepatic thiols were assessed. Significant increases in GSH (1.5-fold), cysteine (15-fold), and glutamate cysteine ligase activity (1.5-fold) were observed in iron-loaded livers, whereas telomerase activity was inhibited by treatment with N-ethylmaleimide. This is the first demonstration of increased telomerase activity associated with thiol alterations in vivo. Enhanced telomerase activity may be an important factor contributing to the resistance of rodent liver to iron-induced damage. JF - Free radical biology & medicine AU - Brown, Kyle E AU - Meleah Mathahs, M AU - Broadhurst, Kimberly A AU - Coleman, Mitchell C AU - Ridnour, Lisa A AU - Schmidt, Warren N AU - Spitz, Douglas R AD - Iowa City Veterans Administration Medical Center, Iowa City, IA, USA. kyle-brown@uiowa.edu Y1 - 2007/01/15/ PY - 2007 DA - 2007 Jan 15 SP - 228 EP - 235 VL - 42 IS - 2 SN - 0891-5849, 0891-5849 KW - Sulfhydryl Compounds KW - 0 KW - Iron KW - E1UOL152H7 KW - Telomerase KW - EC 2.7.7.49 KW - Glutathione KW - GAN16C9B8O KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Animals KW - Cysteine -- metabolism KW - Glutathione -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - Cysteine -- drug effects KW - Glutathione -- drug effects KW - Chromatography, High Pressure Liquid KW - Rats KW - Rats, Sprague-Dawley KW - Blotting, Western KW - Blotting, Southern KW - Oxidative Stress -- drug effects KW - Enzyme-Linked Immunosorbent Assay KW - Iron -- toxicity KW - Male KW - Liver -- enzymology KW - Sulfhydryl Compounds -- metabolism KW - Oxidation-Reduction -- drug effects KW - Telomere -- drug effects KW - Telomerase -- metabolism KW - Iron Overload -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68378449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Increased+hepatic+telomerase+activity+in+a+rat+model+of+iron+overload%3A+a+role+for+altered+thiol+redox+state%3F&rft.au=Brown%2C+Kyle+E%3BMeleah+Mathahs%2C+M%3BBroadhurst%2C+Kimberly+A%3BColeman%2C+Mitchell+C%3BRidnour%2C+Lisa+A%3BSchmidt%2C+Warren+N%3BSpitz%2C+Douglas+R&rft.aulast=Brown&rft.aufirst=Kyle&rft.date=2007-01-15&rft.volume=42&rft.issue=2&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-22 N1 - Date created - 2006-12-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 1997 Sep 4;15(10):1233-40 [9294617] J Biol Chem. 2001 May 11;276(19):15571-4 [11274138] Free Radic Biol Med. 1998 Mar 1;24(4):545-55 [9559866] Biochem Biophys Res Commun. 1998 May 8;246(1):13-9 [9600060] Exp Cell Res. 1998 Jul 10;242(1):120-7 [9665809] Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10471-6 [9724727] J Biol Chem. 1999 Jan 8;274(2):962-71 [9873038] J Biol Chem. 1999 May 7;274(19):13085-90 [10224060] Mol Carcinog. 1999 Aug;25(4):241-8 [10449030] Biochemistry. 1999 Aug 31;38(35):11501-7 [10471302] Free Radic Biol Med. 2005 May 15;38(10):1361-71 [15855054] Nat Rev Genet. 2005 Aug;6(8):611-22 [16136653] Hum Pathol. 2001 Mar;32(3):327-32 [11274643] FEBS Lett. 2001 Jan 19;488(3):133-8 [11163759] Brain Res Dev Brain Res. 2001 Nov 26;131(1-2):167-71 [11718848] FASEB J. 2002 Jul;16(9):935-42 [12087054] Cancer Res. 2002 Jul 1;62(13):3876-82 [12097303] J Biol Chem. 2002 Oct 11;277(41):38540-9 [12140282] Cancer Res. 2003 Jan 1;63(1):18-21 [12517770] FEBS Lett. 2003 Feb 11;536(1-3):180-6 [12586360] Nucleic Acids Res. 2003 Mar 1;31(5):1576-83 [12595567] Blood. 2003 Jun 1;101(11):4512-9 [12586632] EMBO J. 2003 Aug 1;22(15):4003-13 [12881434] Liver Int. 2003 Aug;23(4):232-42 [12895262] J Biol Chem. 2003 Aug 22;278(34):31998-2004 [12767976] Lancet. 2003 Sep 20;362(9388):983-8 [14511933] Hepatology. 2004 Feb;39(2):273-8 [14767974] Gut. 2004 Jul;53(7):1001-9 [15194652] J Biol Chem. 2004 Aug 13;279(33):34332-5 [15184392] Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10114-8 [1438199] Hepatology. 1995 Feb;21(2):521-8 [7843726] Biochem Biophys Res Commun. 1995 Jun 6;211(1):33-9 [7779103] Exp Cell Res. 1995 Sep;220(1):186-93 [7664835] Transl Res. 2006 Aug;148(2):55-62 [16890145] FASEB J. 1999 Dec;13(15):2091-104 [10593857] Free Radic Biol Med. 2000 Jan 1;28(1):64-74 [10656292] Science. 2000 Feb 18;287(5456):1253-8 [10678830] Exp Cell Res. 2000 May 1;256(2):578-82 [10772830] Lab Invest. 2000 Nov;80(11):1739-47 [11092534] Toxicol Pathol. 1997 Nov-Dec;25(6):556-64 [9437799] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interferon alpha therapy for hepatitis C: treatment completion and response rates among patients with substance use disorders. AN - 68947058; 17222348 AB - Individuals with substance use disorders (SUDs) are at increased risk for hepatitis C viral infection (HCV), and few studies have explored their treatment responses empirically. The objective of this study was to assess interferon alpha therapy (IFN) completion and response rates among patients with HCV who had a history of comorbid SUDs. More data is needed to inform treatment strategies and guidelines for these patients. Using a medical record database, information was retrospectively collected on 307,437 veterans seen in the Veterans Integrated Service Network 20 (VISN 20) of the Veterans Healthcare Administration (VHA) between 1998 and 2003. For patients treated with any type of IFN (including regular or pegylated IFN) or combination therapy (IFN and ribavirin) who had a known HCV genotype, IFN completion and response rates were compared among patients with a history of SUD (SUD+ Group) and patients without a history of SUD (SUD- Group). Odds ratio analyses revealed that compared with the SUD- Group, the SUD+ Group was equally likely to complete IFN therapy if they had genotypes 2 and 3 (73.1% vs. 68.0%), and if they had genotypes 1 and 4 (39.5% vs. 39.9%). Within the sample of all patients who began IFN therapy, the SUD- and SUD+ groups were similarly likely to achieve an end of treatment response (genotypes 2 and 3, 52.8% vs. 54.3%; genotypes 1 and 4, 24.5% vs. 24.8%) and a sustained viral response (genotypes 2 and 3, 42.6% vs. 41.1%; genotypes 1 and 4: 16.0% vs. 22.3%). Individuals with and without a history of SUD responded to antiviral therapy for HCV at similar rates. Collectively, these findings suggest that patients who have co-morbid SUD and HCV diagnoses can successfully complete a course of antiviral therapy. JF - Substance abuse treatment, prevention, and policy AU - Huckans, Marilyn S AU - Loftis, Jennifer M AU - Blackwell, Aaron D AU - Linke, Alex AU - Hauser, Peter AD - Northwest Hepatitis C Resource Center, Portland VA Medical Center, Portland, USA. marilyn.huckans@va.gov Y1 - 2007/01/12/ PY - 2007 DA - 2007 Jan 12 SP - 4 VL - 2 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - Index Medicus KW - Viral Load KW - Veterans KW - Genotype KW - Hepacivirus -- genetics KW - Humans KW - Treatment Outcome KW - Retrospective Studies KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Comorbidity KW - Antiviral Agents -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - Hepatitis C -- drug therapy KW - Medication Adherence -- statistics & numerical data KW - Hepatitis C -- epidemiology KW - Hepatitis C -- genetics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68947058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse+treatment%2C+prevention%2C+and+policy&rft.atitle=Interferon+alpha+therapy+for+hepatitis+C%3A+treatment+completion+and+response+rates+among+patients+with+substance+use+disorders.&rft.au=Huckans%2C+Marilyn+S%3BLoftis%2C+Jennifer+M%3BBlackwell%2C+Aaron+D%3BLinke%2C+Alex%3BHauser%2C+Peter&rft.aulast=Huckans&rft.aufirst=Marilyn&rft.date=2007-01-12&rft.volume=2&rft.issue=&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Substance+abuse+treatment%2C+prevention%2C+and+policy&rft.issn=1747-597X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-07 N1 - Date created - 2007-01-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Alcohol Alcohol. 2000 May-Jun;35(3):296-301 [10869251] Gastroenterology. 2006 May;130(6):1607-16 [16697724] Am J Gastroenterol. 2001 Jan;96(1):157-64 [11197246] JAMA. 2001 Feb 28;285(8):1003-5 [11209154] Subst Use Misuse. 2001 Mar;36(4):523-34 [11346280] J Interferon Cytokine Res. 2001 May;21(5):273-8 [11429157] Hepatology. 2001 Jul;34(1):188-93 [11431750] N Engl J Med. 2001 Jul 19;345(3):211-5 [11463019] N Engl J Med. 2001 Jul 19;345(3):215-7 [11463020] Lancet. 2001 Sep 22;358(9286):958-65 [11583749] Am J Gastroenterol. 2002 Jan;97(1):149-55 [11808940] Eur Addict Res. 2002 Jan;8(1):45-9 [11818693] J Clin Gastroenterol. 2002 Mar;34(3):268-71 [11873110] J Viral Hepat. 2002 Jul;9(4):288-94 [12081606] Drug Alcohol Depend. 2002 Jul 1;67(2):117-23 [12095661] Gastroenterology. 2002 Aug;123(2):476-82 [12145801] N Engl J Med. 2002 Sep 26;347(13):975-82 [12324553] Mol Psychiatry. 2002;7(9):942-7 [12399946] Hepatology. 2002 Nov;36(5 Suppl 1):S3-20 [12407572] Hepatology. 2002 Nov;36(5 Suppl 1):S237-44 [12407599] Am J Psychiatry. 2003 Jan;160(1):172-4 [12505819] Psychosomatics. 2003 Mar-Apr;44(2):104-12 [12618532] Psychiatr Serv. 2003 Jun;54(6):842-7 [12773598] Hepatology. 2004 Apr;39(4):1147-71 [15057920] Addiction. 2004 Sep;99(9):1167-75 [15317637] J Affect Disord. 2004 Oct 15;82(2):175-90 [15488246] Scand J Gastroenterol. 1994 Nov;29(11):1039-43 [7871371] Am J Gastroenterol. 1996 Jul;91(7):1374-9 [8677998] Infection. 2005 Feb;33(1):25-9 [15750756] Clin Infect Dis. 2005 Apr 15;40 Suppl 5:S276-85 [15768335] Clin Infect Dis. 2005 Apr 15;40 Suppl 5:S321-4 [15768341] Aliment Pharmacol Ther. 2005 Apr 15;21(8):1007-15 [15813837] Acta Gastroenterol Belg. 2005 Jan-Mar;68(1):55-67 [15832589] Acta Gastroenterol Belg. 2005 Jan-Mar;68(1):68-80 [15832590] Psychiatr Serv. 2006 Mar;57(3):403-6 [16525001] Can J Public Health. 2000 Jul-Aug;91 Suppl 1:S18-21, S19-23 [11059125] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute drug induced hepatitis due to erlotinib. AN - 68921882; 17228132 AB - Acute drug induced hepatitis has not been commonly associated with epidermal growth factor receptor (EGFR) inhibitors. Hepatotoxicity seen with erlotinib, a small molecule tyrosine kinase inhibitor to EGFR, is usually transient with mild elevation of transaminases. We report a case of acute severe hepatitis resulting from erlotinib monotherapy in a patient with locally advanced pancreatic cancer. Hepatotoxicity resolved once erlotinib was discontinued and serum transaminases returned to baseline normal values. Acute severe hepatitis though rare is occasionally observed with EGFR inhibitors gefitinib or erlotinib. As EGFR inhibitors are now incorporated with chemotherapy in advanced pancreatic cancers, clinicians should be aware of this potential complication. JF - JOP : Journal of the pancreas AU - Ramanarayanan, Jeyanthi AU - Scarpace, Sarah L AD - Division of Hematology and Oncology, Stratton VA Medical Center, Albany, NY 12208, USA. jeyanthi.ramanarayanan2@med.va.gov Y1 - 2007/01/09/ PY - 2007 DA - 2007 Jan 09 SP - 39 EP - 43 VL - 8 IS - 1 KW - Protein Kinase Inhibitors KW - 0 KW - Quinazolines KW - Erlotinib Hydrochloride KW - DA87705X9K KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Aspartate Aminotransferases -- blood KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Alanine Transaminase -- blood KW - Humans KW - Aged KW - Male KW - Chemical and Drug Induced Liver Injury -- blood KW - Chemical and Drug Induced Liver Injury -- etiology KW - Protein Kinase Inhibitors -- adverse effects KW - Quinazolines -- adverse effects KW - Pancreatic Neoplasms -- drug therapy KW - Adenocarcinoma -- drug therapy KW - Chemical and Drug Induced Liver Injury -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68921882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JOP+%3A+Journal+of+the+pancreas&rft.atitle=Acute+drug+induced+hepatitis+due+to+erlotinib.&rft.au=Ramanarayanan%2C+Jeyanthi%3BScarpace%2C+Sarah+L&rft.aulast=Ramanarayanan&rft.aufirst=Jeyanthi&rft.date=2007-01-09&rft.volume=8&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=JOP+%3A+Journal+of+the+pancreas&rft.issn=1590-8577&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-21 N1 - Date created - 2007-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Motor vehicle transportation use and related adverse events among persons who use wheelchairs. AN - 85406065; pmid-18335707 AB - For the 2.2 million people who use wheelchairs in the United States, transportation is often needed for independence in the community. The purpose of this study was to investigate the characteristics of transportation use in a population of wheelchair users and to examine the motor vehicle crash involvement and injury frequency of these users. Responses were collected from 596 individuals from June 2002 to November 2003. Approximately 20% of the sample population was involved in a motor vehicle crash in the previous 3 years, resulting in a rate of 3.6 accidents/incidents per 100,000 miles traveled. Crashes were defined as any motor vehicle accident that the person was involved in during the previous 3 years. Persons who did not transfer from their wheelchair were more likely to be involved in a crash than those individuals who transferred to vehicle seats. Eighteen percent of the population reported involvement in a non-crash-related incident during the previous 3 years. Passengers reported a greater frequency of non-crash-related injuries than did drivers. The results of this study provide documentation of transportation use and safety in people who use wheelchairs. It provides insight into the risk of crash and injury in this population. JF - Assistive technology : the official journal of RESNA AU - Fitzgerald, Shirley G AU - Songer, Thomas AU - Rotko, Katherine A AU - Karg, Patricia AD - James A. Haley VA Hospital, Patient Safety Center (118M), 11605 N. Nebraska Ave., Tampa, FL 33612, USA. shirleyfitzgerald@va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 180 EP - 187 VL - 19 IS - 4 SN - 1040-0435, 1040-0435 KW - Health technology assessment KW - National Library of Medicine KW - *Accidents, Traffic: statistics & numerical data KW - Adolescent KW - Adult KW - Aged KW - *Automobiles: standards KW - Child KW - Child, Preschool KW - Cross-Sectional Studies KW - Disabled Persons KW - Female KW - Health Surveys KW - Humans KW - Infant KW - Infant, Newborn KW - Male KW - Middle Aged KW - *Motor Vehicles: statistics & numerical data KW - *Protective Devices: statistics & numerical data KW - Risk Factors KW - Safety Management KW - *Transportation KW - *Wheelchairs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85406065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assistive+technology+%3A+the+official+journal+of+RESNA&rft.atitle=Motor+vehicle+transportation+use+and+related+adverse+events+among+persons+who+use+wheelchairs.&rft.au=Fitzgerald%2C+Shirley+G%3BSonger%2C+Thomas%3BRotko%2C+Katherine+A%3BKarg%2C+Patricia&rft.aulast=Fitzgerald&rft.aufirst=Shirley&rft.date=2007-01-01&rft.volume=19&rft.issue=4&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Assistive+technology+%3A+the+official+journal+of+RESNA&rft.issn=10400435&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Concurrent chemoradiation for locally advanced oropharyngeal cancer. AN - 85405209; pmid-17162122 AB - The aim of this study was to assess the survival, pattern of failure, morbidity, and prognostic factors of concurrent chemoradiation for locally advanced oropharyngeal cancer.A retrospective survey of patients who underwent chemotherapy and radiation for locally advanced oropharyngeal carcinoma at the Veteran Affairs North Texas Health Care System, Dallas, Tex.Between December 1999 and September 2004, 48 patients with locally advanced oropharyngeal cancer underwent concurrent chemotherapy and radiation. At a median follow-up of 23 months, the 3- and 5-year survival for the whole group were, respectively, 52% and 41%. Seventeen patients (35%) developed recurrences. There were 12 (25%) locoregional failures (6 local failures alone and 6 local and regional failures). Distant metastases developed in 8 patients (5 alone, 3 associated with locoregional failures). Four patients (8%) developed second primaries. No difference was observed in survival between base of tongue and tonsillar carcinoma (P = .32). The 5-year survival for T1-T2 and T3-T4 tumors was, respectively, 84% and 27% (P = .01). No patient with T1-T2 tumors developed distant metastases (P = .04). Forty-five patients (94%) developed toxicity grade 3 to 4 (40 mucositis and 26 hematological). The median weight loss was 18 lb (range, 0-47 lb). Eight patients (16%) developed aspiration pneumonia during and after treatment. Five patients (10%) died of aspiration (2 during and 3 post treatment). Four patients (8%) developed esophageal strictures requiring repeated dilatations post treatment. Two patients had radionecrosis (1 soft tissue and 1 bone) requiring hyperbaric oxygen. Eighteen patients (37%) had prolonged tube feedings (>3 months) after treatments because of severe dysphagia or aspiration.Concurrent chemoradiation provided good locoregional control for locally advanced oropharyngeal carcinoma. Patients with small tumors (T1-T2) had excellent survival. The poor prognosis associated with large tumors may be due to the risk of developing distant metastases. Acute and late toxicities remained significant. Aspiration pneumonia and severe dysphagia were the most prevalent complications of the combined modality approach. JF - American journal of otolaryngology AU - Nguyen, Nam P AU - Vos, Paul AU - Smith, Herbert J AU - Nguyen, Phuc D AU - Alfieri, Alan AU - Karlsson, Ulf AU - Dutta, Suresh AU - Lemanski, Claire AU - Nguyen, Ly M AU - Sallah, Sabah AD - Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA. namphong.nguyen@med.va.gov Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 3 EP - 8 VL - 28 IS - 1 SN - 0196-0709, 0196-0709 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Antimetabolites, Antineoplastic: therapeutic use KW - Combined Modality Therapy KW - Fluorouracil: therapeutic use KW - Humans KW - Male KW - Middle Aged KW - Neoplasm Recurrence, Local KW - Oropharyngeal Neoplasms: complications KW - *Oropharyngeal Neoplasms: drug therapy KW - Oropharyngeal Neoplasms: pathology KW - *Oropharyngeal Neoplasms: radiotherapy KW - Prognosis KW - Radiotherapy Dosage KW - Retrospective Studies KW - Survival Rate KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85405209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+otolaryngology&rft.atitle=Concurrent+chemoradiation+for+locally+advanced+oropharyngeal+cancer.&rft.au=Nguyen%2C+Nam+P%3BVos%2C+Paul%3BSmith%2C+Herbert+J%3BNguyen%2C+Phuc+D%3BAlfieri%2C+Alan%3BKarlsson%2C+Ulf%3BDutta%2C+Suresh%3BLemanski%2C+Claire%3BNguyen%2C+Ly+M%3BSallah%2C+Sabah&rft.aulast=Nguyen&rft.aufirst=Nam&rft.date=2007-01-01&rft.volume=28&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=American+journal+of+otolaryngology&rft.issn=01960709&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Levodopa-induced hyperactivity in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. AN - 85403605; pmid-17133519 AB - The present study examines the motor responses of 10- to 12-month-old, male C57 mice that were either given intraperitoneal (IP) injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg per day) or vehicle for 10 consecutive days, followed by IP injections of levodopa (200 mg/kg) plus carbidopa (25 mg/kg). Five days of MPTP exposure resulted in the Straub tail phenomenon and pronounced hypokinesia. However, during the next 5 days, motor activity returned to baseline, even with continued MPTP treatment. After 10 to 14 days of rest, all mice were then treated with levodopa/carbidopa twice daily for multiple, consecutive days. However, only the previously MPTP-treated animals became hyperkinetic, as compared to levodopa-treated control animals that were not previously exposed to MPTP. Abnormal activity included scratching, running, gnawing, and jumping movements. Hyperactivity lasted for approximately 2 hours after each levodopa injection and then returned to baseline, but the amount of hyperkinesia increased with additional days of levodopa treatment, even though the daily levodopa dose was not changed. These results demonstrate that levodopa can cause reproducible hyperactivity in mice that were previously exposed to MPTP.Copyright 2006 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Nicholas, Anthony P AD - Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, Alabama 35294-0017, USA. nicholas@uab.edu Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 99 EP - 104 VL - 22 IS - 1 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - *1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: therapeutic use KW - Age Factors KW - Animals KW - Disease Models, Animal KW - *Dopamine Agents: therapeutic use KW - Hyperkinesis: chemically induced KW - *Hyperkinesis: drug therapy KW - *Levodopa KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Movement: drug effects KW - Time Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85403605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Levodopa-induced+hyperactivity+in+mice+treated+with+1-methyl-4-phenyl-1%2C2%2C3%2C6-tetrahydropyridine.&rft.au=Nicholas%2C+Anthony+P&rft.aulast=Nicholas&rft.aufirst=Anthony&rft.date=2007-01-01&rft.volume=22&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Neuropsychological performance following staged bilateral pallidal or subthalamic nucleus deep brain stimulation for Parkinson's disease. AN - 85402753; pmid-17166305 AB - Deep brain stimulation (DBS) has the potential to significantly reduce motor symptoms in advanced Parkinson's disease (PD). Controversy remains about non-motor effects of DBS and the relative advantages of treatment at two brain targets, the globus pallidus internus (GPi) and the subthalamic nucleus (STN). We investigated effects of DBS on neuropsychological functioning in 42 patients with advanced PD randomly assigned to receive staged bilateral DBS surgery of either the GPi or STN. Patients underwent neuropsychological assessment prior to and 6 months after unilateral surgery. Twenty-nine subsequently underwent surgery to the contralateral side and completed a second follow-up neuropsychological evaluation 15 months later. Unilateral treatment resulted in small but statistically significant reductions in performance on several measures, including verbal fluency and working memory. A similar pattern was observed after bilateral treatment. Reductions in verbal associative fluency were significant only after left-sided treatment. There were few significant differences related to treatment at the two surgical targets. Supplementary analyses suggested that decrements in select neuropsychological domains following DBS are unrelated to age or post-surgical reduction in dopaminergic medication dose. Findings are discussed with reference to possible causes of neuropsychological decline and the need for further controlled studies of specific neuropsychological effects of DBS. JF - Journal of the International Neuropsychological Society : JINS AU - Rothlind, Johannes C AU - Cockshott, Randall W AU - Starr, Philip A AU - Marks, William J AD - Mental Health Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA. Johannes.Rothlind@Med.VA.Gov Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 68 EP - 79 VL - 13 IS - 1 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - *Cognition Disorders: diagnosis KW - *Cognition Disorders: epidemiology KW - *Deep Brain Stimulation: methods KW - Female KW - Follow-Up Studies KW - Functional Laterality: physiology KW - *Globus Pallidus: physiology KW - Humans KW - Male KW - Middle Aged KW - *Neuropsychological Tests KW - *Parkinson Disease: epidemiology KW - *Parkinson Disease: therapy KW - Severity of Illness Index KW - *Subthalamic Nucleus: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85402753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Neuropsychological+performance+following+staged+bilateral+pallidal+or+subthalamic+nucleus+deep+brain+stimulation+for+Parkinson%27s+disease.&rft.au=Rothlind%2C+Johannes+C%3BCockshott%2C+Randall+W%3BStarr%2C+Philip+A%3BMarks%2C+William+J&rft.aulast=Rothlind&rft.aufirst=Johannes&rft.date=2007-01-01&rft.volume=13&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The Attitudes towards Loss of Hearing Questionnaire (ALHQ): a comparison of paper and electronic formats. AN - 85392695; pmid-17252959 AB - The purpose of the study was to determine whether scores obtained on the ALHQ when completed in electronic format are the same as when completed in paper format. Four groups of 25 individuals participated. Each completed the ALHQ on two occasions in either its paper version, its electronic version, or both. The variance in ALHQ scores from the first to second administrations was compared across test groups. Data showed that the two forms of the questionnaire yielded equivalent scores but that completion in different modes on both occasions resulted in more variability in scores than completion in the same mode on both occasions. It is concluded that when comparing questionnaire data across administrations, the same response format should be used. Electronic completion took longer than paper completion, but it is concluded that the numerous advantages of electronic administration outweigh the disadvantages of additional completion time. JF - Journal of the American Academy of Audiology AU - Saunders, Gabrielle AU - Forsline, Anna AU - Jacobs, Peter AD - National Center for Rehabilitative Auditory Research, Portland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97213, USA. Gabrielle.saunders@med.va.gov Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 66 EP - 77 VL - 18 IS - 1 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - *Attitude to Health KW - Female KW - *Hearing Aids KW - *Hearing Loss, Sensorineural: therapy KW - Humans KW - Male KW - Middle Aged KW - *Questionnaires KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85392695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=The+Attitudes+towards+Loss+of+Hearing+Questionnaire+%28ALHQ%29%3A+a+comparison+of+paper+and+electronic+formats.&rft.au=Saunders%2C+Gabrielle%3BForsline%2C+Anna%3BJacobs%2C+Peter&rft.aulast=Saunders&rft.aufirst=Gabrielle&rft.date=2007-01-01&rft.volume=18&rft.issue=1&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Pathobiology of alcoholic pancreatitis. AN - 70750645; 17592222 AB - This paper provides a summary of the effects of alcohol abuse on the pathobiologic responses that occur during acute and chronic pancreatitis considering both the human disease and animal/tissue models. The effects are multiple and include ones on cell death leading to necrosis; on inflammation resulting in a sensitized response to pancreatic stress; and fibrosis through effects of ethanol on pancreatic stellate cells and the plasminogen system. Although the effects of alcohol are multiple and complex, it is likely that a combination of a few key effects on these pathobiologic responses drive the increased sensitivity of the pancreas to acute pancreatitis with pancreatic stress and the promotion of chronic pancreatitis with pancreatic injury occurring during acute pancreatitis. (c) 2007 S. Karger AG, Basel and IAP. JF - Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] AU - Pandol, Stephen J AU - Raraty, Michael AD - Department of Medicine, University of California, Department of Veterans Affairs, Los Angeles, California, USA. stephen.pandol@va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 105 EP - 114 VL - 7 IS - 2-3 SN - 1424-3903, 1424-3903 KW - Index Medicus KW - Acute Disease KW - Humans KW - Alcohol Drinking -- metabolism KW - Pancreatitis, Alcoholic -- metabolism KW - Alcohol Drinking -- adverse effects KW - Pancreatitis, Alcoholic -- pathology KW - Pancreatitis, Alcoholic -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70750645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pancreatology+%3A+official+journal+of+the+International+Association+of+Pancreatology+%28IAP%29+...+%5Bet+al.%5D&rft.atitle=Pathobiology+of+alcoholic+pancreatitis.&rft.au=Pandol%2C+Stephen+J%3BRaraty%2C+Michael&rft.aulast=Pandol&rft.aufirst=Stephen&rft.date=2007-01-01&rft.volume=7&rft.issue=2-3&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Pancreatology+%3A+official+journal+of+the+International+Association+of+Pancreatology+%28IAP%29+...+%5Bet+al.%5D&rft.issn=14243903&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cognitive impairment and pain management: review of issues and challenges. AN - 70598634; 17551882 AB - The assessment and treatment of pain in persons with cognitive impairments pose unique challenges. Disorders affecting cognition include neurodegenerative, vascular, toxic, anoxic, and infectious processes. Persons with memory, language, and speech deficits and consciousness alterations are often unable to communicate clearly about their pain and discomfort. Past research has documented that persons with cognitive impairments, particularly dementia, are less likely to ask for and receive analgesics. This article provides an overview of the assessment, treatment, and management of pain in adults with cognitive impairments. We review types of cognitive impairment; recent work specific to best practices for pain management in patients with dementia, including assessment-tool development and pharmacological treatment; challenges in patients with delirium and in medical intensive care and palliative care settings; and directions for future research. JF - Journal of rehabilitation research and development AU - Buffum, Martha D AU - Hutt, Evelyn AU - Chang, Victor T AU - Craine, Michael H AU - Snow, A Lynn AD - Department of Veterans Affairs (VA) Medical Center (VAMC), 4150 Clement St (118), San Francisco, CA 94121, USA. Martha.Buffum@va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 315 EP - 330 VL - 44 IS - 2 KW - Index Medicus KW - Veterans KW - Evidence-Based Medicine KW - Aged, 80 and over KW - Humans KW - Frail Elderly KW - Palliative Care KW - Pain Measurement KW - Aged KW - Pain Management KW - Pain -- psychology KW - Dementia -- complications KW - Pain -- diagnosis KW - Delirium -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70598634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+rehabilitation+research+and+development&rft.atitle=Cognitive+impairment+and+pain+management%3A+review+of+issues+and+challenges.&rft.au=Buffum%2C+Martha+D%3BHutt%2C+Evelyn%3BChang%2C+Victor+T%3BCraine%2C+Michael+H%3BSnow%2C+A+Lynn&rft.aulast=Buffum&rft.aufirst=Martha&rft.date=2007-01-01&rft.volume=44&rft.issue=2&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+rehabilitation+research+and+development&rft.issn=1938-1352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-07 N1 - Date created - 2007-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Persistent benefits of rehabilitation on pain and life quality for nonambulatory patients with spinal epidural metastasis. AN - 70589166; 17551878 AB - We determined whether the benefits of directed rehabilitation for pain, depression, and satisfaction with life persisted for veterans who were nonambulatory after spinal epidural metastasis (SEM) treatment. Twelve consecutive veterans (paraplegic after SEM treatment) who received 2 weeks of directed rehabilitation were compared with a historical control group of thirty paraplegic veterans who did not receive rehabilitation. Subjects were followed until death. Pain levels, depression, satisfaction with life, and consumption of pain medication were measured. Subjects who received rehabilitation had less pain, consumed less pain medication, were less depressed, and had higher satisfaction with life. The benefits to the rehabilitated subjects persisted until their deaths. We conclude that spinal cord injury rehabilitation for nonambulatory subjects with SEM produces persistent benefits for pain, depression, and satisfaction with life. JF - Journal of rehabilitation research and development AU - Ruff, Robert L AU - Ruff, Suzanne S AU - Wang, Xiaofeng AD - Neurology Service 127(W), Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA. robert.ruff1@va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 271 EP - 278 VL - 44 IS - 2 KW - Analgesics KW - 0 KW - Index Medicus KW - Outpatients KW - Mobility Limitation KW - Depression KW - Patient Satisfaction KW - Humans KW - Case-Control Studies KW - Quality of Life KW - Palliative Care KW - Aged KW - Middle Aged KW - Analgesics -- therapeutic use KW - Radiotherapy -- adverse effects KW - Spinal Neoplasms -- secondary KW - Spinal Cord Compression -- rehabilitation KW - Pain -- etiology KW - Pain -- rehabilitation KW - Pain -- drug therapy KW - Spinal Cord Compression -- etiology KW - Spinal Neoplasms -- radiotherapy KW - Spinal Neoplasms -- complications KW - Spinal Cord Compression -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70589166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+rehabilitation+research+and+development&rft.atitle=Persistent+benefits+of+rehabilitation+on+pain+and+life+quality+for+nonambulatory+patients+with+spinal+epidural+metastasis.&rft.au=Ruff%2C+Robert+L%3BRuff%2C+Suzanne+S%3BWang%2C+Xiaofeng&rft.aulast=Ruff&rft.aufirst=Robert&rft.date=2007-01-01&rft.volume=44&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Journal+of+rehabilitation+research+and+development&rft.issn=1938-1352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-07 N1 - Date created - 2007-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The interrelation between organophosphate toxicity and the epidemiology of depression and suicide. AN - 70507058; 17508698 AB - The literature on an association between organophosphate (OP) toxicity and depression or suicide is scarce. An interrelation exists among populations exposed to OPs, acute OP toxicity, neurobehavioral effects, depression, suicide, and fatality. Acute OP toxicity is characterized by the cholinergic syndrome with systemic and central nervous system effects. Organophosphate-induced neurobehavioral effects result in depression. A potential risk of depression and suicide exists in farm workers exposed to OPs. The sociodemographics of depression include age, gender, race, geographic region, social factors, economics, psychiatric disorders, medical conditions, and hereditary factors. Suicide is a major consequence of depression, with multiple sociodemographic risk factors. Developing countries have a higher incidence of OP toxicity, with limited information on the prevalence of depression. In these countries, the incidence of suicide is high, affecting more females. Suicide is more prevalent in rural areas, and in farming communities, commonly with ingestion of OPs. In industrialized countries, the incidence of OP toxicity is lower, but the prevalence of depression is higher. Suicide rates are lower in industrialized countries, affecting more males, the urban population, and farming communities. Other lethal methods of suicide, such as hanging, firearms, electrocution, and drug overdose are more common in industrialized countries. A potential risk of depression or suicide certainly exists from OP toxicity, largely depending on the epidemiology or sociodemographics of these disorders. Scientific evidence shows that the association between environmental toxicology and psychiatry has important public health implications. JF - Reviews on environmental health AU - Jaga, Kushik AU - Dharmani, Chandrabhan AD - Mount Sinai School of Medicine, Department of Psychiatry, New York, NY, USA. Kushik.Jaga@va.gov PY - 2007 SP - 57 EP - 73 VL - 22 IS - 1 SN - 0048-7554, 0048-7554 KW - Organophosphates KW - 0 KW - Index Medicus KW - Agriculture KW - Humans KW - Adult KW - Middle Aged KW - Developing Countries KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Suicide -- trends KW - Organophosphate Poisoning KW - Depression -- epidemiology KW - Occupational Exposure -- adverse effects KW - Organophosphates -- adverse effects KW - Depression -- chemically induced KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70507058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+on+environmental+health&rft.atitle=The+interrelation+between+organophosphate+toxicity+and+the+epidemiology+of+depression+and+suicide.&rft.au=Jaga%2C+Kushik%3BDharmani%2C+Chandrabhan&rft.aulast=Jaga&rft.aufirst=Kushik&rft.date=2007-01-01&rft.volume=22&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Reviews+on+environmental+health&rft.issn=00487554&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-26 N1 - Date created - 2007-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk factors for suicide attempts among alcohol dependent patients. AN - 70427332; 17453699 AB - Suicidal behavior is a common and important problem among alcohol dependent patients. The study was designed to examine risk factors for attempting suicide in 499 alcohol dependent patients. Those who had attempted suicide (N = 198) were more likely to be female, report a family history of suicidal behavior, report more childhood trauma, report greater levels of aggressive behavior, began heavy drinking earlier, and were more likely to have received antidepressant medication. Logistic regression analysis showed that gender, family history, and childhood sexual abuse history made significant and independent contributions to the risk of a suicide attempt. Thus, developmental, personality, family history, social, and comorbidity risk factors may differentiate alcohol dependent patients who have attempted suicide from those who have not. JF - Archives of suicide research : official journal of the International Academy for Suicide Research AU - Roy, Alec AU - Janal, Malvin N AD - Psychiatry Service, New Jersey VA Health Care System, New Jersey 07018, USA. Alec.Roy@med.va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 211 EP - 217 VL - 11 IS - 2 SN - 1381-1118, 1381-1118 KW - Index Medicus KW - Logistic Models KW - Risk Factors KW - Humans KW - Child KW - New Jersey KW - Male KW - Female KW - Suicide, Attempted -- statistics & numerical data KW - Suicide, Attempted -- psychology KW - Alcoholism -- psychology KW - Suicide, Attempted -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70427332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+suicide+research+%3A+official+journal+of+the+International+Academy+for+Suicide+Research&rft.atitle=Risk+factors+for+suicide+attempts+among+alcohol+dependent+patients.&rft.au=Roy%2C+Alec%3BJanal%2C+Malvin+N&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2007-01-01&rft.volume=11&rft.issue=2&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Archives+of+suicide+research+%3A+official+journal+of+the+International+Academy+for+Suicide+Research&rft.issn=13811118&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-14 N1 - Date created - 2007-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Integrating smoking cessation into mental health care for post-traumatic stress disorder. AN - 70421647; 17456521 AB - Post-traumatic stress disorder (PTSD) is associated with a high prevalence of smoking, heavy cigarette consumption and low cessation rates. This manuscript describes the design of a randomized, multisite effectiveness trial to test whether integrating smoking cessation treatment into mental health care (integrated care) improves prolonged abstinence rates among veterans with PTSD, compared with referral to specialized smoking cessation clinics (usual standard of care). Secondary objectives are to assess the cost-effectiveness of integrated care relative to usual standard of care, identify treatment variables that mediate differences between conditions in outcome and determine whether smoking cessation is associated with worsening PTSD and/or depression. Following randomization, subjects (projected n = 1400) from 10 Veterans Health Administration (VHA) medical centers complete follow-up assessments every three or six months for up to four years. Endpoints include 1-year prolonged abstinence at 18 months postrandomization, 7- and 30-day point-prevalence abstinence and measures of depression, PTSD and economic outcomes. This study is unique in providing the largest scale test of the feasibility and effectiveness of having mental health clinicians implement evidence-based smoking cessation treatment in psychiatric care settings for veterans with PTSD. It incorporates methodological features that are desirable for cessation treatment trials, including: a) assessment of clinically meaningful long-term smoking outcomes; b) a manual guiding delivery of the experimental intervention; c) independent ratings of clinician competence and treatment adherence and d) methods for training clinicians that would enhance implementation of tobacco cessation treatment in large health care systems. Use of an exclusively VHA sample with few females limits generalizability. The process for meeting challenges in designing this study may provide planning of other large-scale clinical effectiveness trials in tobacco control. Findings have potential to initiate system-wide change in clinical practice patterns for tobacco cessation treatment involving patients with mental disorders. JF - Clinical trials (London, England) AU - McFall, Miles AU - Saxon, Andrew J AU - Thaneemit-Chen, Surai AU - Smith, Mark W AU - Joseph, Anne M AU - Carmody, Timothy P AU - Beckham, Jean C AU - Malte, Carol A AU - Vertrees, Julia E AU - Boardman, Kathy D AU - Lavori, Philip W AD - Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA. miles.mcfall@va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 178 EP - 189 VL - 4 IS - 2 SN - 1740-7745, 1740-7745 KW - Index Medicus KW - Veterans KW - Smoking -- therapy KW - Humans KW - Treatment Outcome KW - Smoking -- psychology KW - Smoking -- epidemiology KW - Comorbidity KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Smoking Cessation -- psychology KW - Stress Disorders, Post-Traumatic -- therapy KW - Tobacco Use Disorder -- therapy KW - Tobacco Use Disorder -- epidemiology KW - Smoking Cessation -- methods KW - Tobacco Use Disorder -- psychology KW - Research Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70421647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+trials+%28London%2C+England%29&rft.atitle=Integrating+smoking+cessation+into+mental+health+care+for+post-traumatic+stress+disorder.&rft.au=McFall%2C+Miles%3BSaxon%2C+Andrew+J%3BThaneemit-Chen%2C+Surai%3BSmith%2C+Mark+W%3BJoseph%2C+Anne+M%3BCarmody%2C+Timothy+P%3BBeckham%2C+Jean+C%3BMalte%2C+Carol+A%3BVertrees%2C+Julia+E%3BBoardman%2C+Kathy+D%3BLavori%2C+Philip+W&rft.aulast=McFall&rft.aufirst=Miles&rft.date=2007-01-01&rft.volume=4&rft.issue=2&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Clinical+trials+%28London%2C+England%29&rft.issn=17407745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-23 N1 - Date created - 2007-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oral health in Veterans Affairs patients diagnosed with serious mental illness. AN - 70395513; 17436978 AB - We evaluated patient and medication treatment factors associated with self-reported oral health status in patients diagnosed with serious mental illness (SMI) in a large, national sample of patients in the Veterans Affairs (VA) health system. 4,769 patients (mean age = 55, 7.8 percent women) were included from the VA's 1999 National Psychosis Registry (NPR) for whom the oral health information gathered by the VA's Large Health Survey of Veterans was available. Current (1999) psychotropic medication data were ascertained from the NPR. Multivariable logistic regression analyses were used to determine the patient factors (e.g., sociodemographic, enabling, and treatment factors) associated with poor or fair overall dental health, and with having tooth or mouth problems that made it difficult to eat. While 61.0 percent of persons with SMI self-reported fair to poor dental health, 34.1 percent reported that oral health problems made it difficult for them to eat. Patients who were not employed, experiencing financial strain, who smoked, who were prescribed tricyclic antidepressants, or prescribed selective serotonin reuptake inhibitors were more likely to report poor or fair dental health. These variables were also associated with having tooth or mouth problems. Suboptimal oral health was self-reported with substantial prevalence among patients with SMI, a problematic finding given its consequences for general health, social functioning, and quality of life. Greater efforts are needed to improve oral health outcomes among patients with SMI by facilitating access to dental care and addressing mutable factors such as smoking and medication side effects. JF - Journal of public health dentistry AU - Kilbourne, Amy M AU - Horvitz-Lennon, Marcela AU - Post, Edward P AU - McCarthy, John F AU - Cruz, Mario AU - Welsh, Deborah AU - Blow, Frederic C AD - VA National Serious Mental Illness Treatment Research and Evaluation Center, Ann Arbor, MI 48105, USA. Amy.Kilbourne@va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 42 EP - 48 VL - 67 IS - 1 SN - 0022-4006, 0022-4006 KW - Psychotropic Drugs KW - 0 KW - Dentistry KW - Index Medicus KW - Oral Health KW - Humans KW - Aged KW - Psychotropic Drugs -- adverse effects KW - Dental Health Surveys KW - Cross-Sectional Studies KW - Ichthyosis -- chemically induced KW - Aged, 80 and over KW - Logistic Models KW - United States Department of Veterans Affairs KW - Adult KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Male KW - Bipolar Disorder -- epidemiology KW - Veterans -- statistics & numerical data KW - Tooth Diseases -- epidemiology KW - Periodontal Diseases -- complications KW - Bipolar Disorder -- drug therapy KW - Schizophrenia -- drug therapy KW - Tooth Diseases -- complications KW - Schizophrenia -- epidemiology KW - Schizophrenia -- complications KW - Bipolar Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70395513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+public+health+dentistry&rft.atitle=Oral+health+in+Veterans+Affairs+patients+diagnosed+with+serious+mental+illness.&rft.au=Kilbourne%2C+Amy+M%3BHorvitz-Lennon%2C+Marcela%3BPost%2C+Edward+P%3BMcCarthy%2C+John+F%3BCruz%2C+Mario%3BWelsh%2C+Deborah%3BBlow%2C+Frederic+C&rft.aulast=Kilbourne&rft.aufirst=Amy&rft.date=2007-01-01&rft.volume=67&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Journal+of+public+health+dentistry&rft.issn=00224006&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-08 N1 - Date created - 2007-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Examining quality issues in alcohol misuse screening. AN - 69058178; 18077303 AB - The Veterans Health Administration (VHA) has successfully implemented evidence- based alcohol misuse screening with the AUDIT-C. The purpose of this study was to evaluate clinical alcohol screening during the first year after implementation. Using medical record review and mailed patient surveys collected during 2004 by VHA Office of Quality and Performance, this study analyzed concordance of screening results among patients with AUDIT-Cs in both data sources. Among 1,637 patients with AUDIT-C from both sources within 90 days, the medical record screening prevalence rate of alcohol misuse, 24.6% (95% CI: 22.5% to 26.7%), was significantly lower than the survey rate, 33.4% (31.1% to 35.7%). Of 8,312 patients identified as nondrinkers in medical records, 24% reported past year alcohol use and 5% screened positive for alcohol misuse on surveys. Lower rates of alcohol use and misuse documented in medical records compared to mailed surveys suggest further investigation and standardization of clinical screening are necessary. JF - Substance abuse AU - Hawkins, Eric J AU - Kivlahan, Daniel R AU - Williams, Emily C AU - Wright, Steven M AU - Craig, Thomas AU - Bradley, Katharine A AD - Health Services Research & Development, Center of Excellence in Substasnce Abuse Treatment and Education, 1160 S Colombian Way, Seattle, WA 98108, USA. Eric.Hawkins@va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 53 EP - 65 VL - 28 IS - 3 SN - 0889-7077, 0889-7077 KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Female KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Mass Screening -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69058178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=Examining+quality+issues+in+alcohol+misuse+screening.&rft.au=Hawkins%2C+Eric+J%3BKivlahan%2C+Daniel+R%3BWilliams%2C+Emily+C%3BWright%2C+Steven+M%3BCraig%2C+Thomas%3BBradley%2C+Katharine+A&rft.aulast=Hawkins&rft.aufirst=Eric&rft.date=2007-01-01&rft.volume=28&rft.issue=3&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adding contingency management intervention to vocational rehabilitation: outcomes for dually diagnosed veterans. AN - 69058066; 18075942 AB - In this random-assignment trial, we evaluated the efficacy of using a contingency management (CM) intervention to enhance job acquisition and tenure among participants of a vocational rehabilitation (VR) program. The CM intervention offered participants cash incentives up to $1,170 for completing tasks related to sobriety and job search and maintenance. Participants were 100 veterans with comorbid psychiatric disorders and substance dependence who were randomly assigned either to VR only or VR + CM. Relative to participants in the VR-only group, those in the VR + CM group showed more intense job searches and transitioned to competitive employment faster and at higher rates. No significant difference was found in job tenure, though this may be due to the limited follow-up period. Abstinence rates were significantly better in the VR + CM group during the first 16 weeks of follow-up but not significantly different in subsequent follow-ups. No relationship was found between relapse and employment. These results suggest that rehabilitation outcomes may be enhanced by adding CM to current programming or by restructuring traditional work-for-pay contingencies to include direct financial rewards for achievement of clinical goals. JF - Journal of rehabilitation research and development AU - Drebing, Charles E AU - Van Ormer, E Alice AU - Mueller, Lisa AU - Hebert, Marcie AU - Penk, Walter E AU - Petry, Nancy M AU - Rosenheck, Robert AU - Rounsaville, Bruce AD - Bedford Department of Veterans Affairs Medical Center, Psychology Service, Bedford, MA 01730, USA. Charles.Drebing@med.va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 851 EP - 865 VL - 44 IS - 6 KW - Index Medicus KW - United States KW - Humans KW - Reinforcement (Psychology) KW - Middle Aged KW - Male KW - Female KW - Employment -- psychology KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- rehabilitation KW - Diagnosis, Dual (Psychiatry) -- methods KW - Mental Disorders -- diagnosis KW - Rehabilitation, Vocational -- methods KW - Veterans -- psychology KW - Workers' Compensation KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- rehabilitation KW - Mental Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69058066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+rehabilitation+research+and+development&rft.atitle=Adding+contingency+management+intervention+to+vocational+rehabilitation%3A+outcomes+for+dually+diagnosed+veterans.&rft.au=Drebing%2C+Charles+E%3BVan+Ormer%2C+E+Alice%3BMueller%2C+Lisa%3BHebert%2C+Marcie%3BPenk%2C+Walter+E%3BPetry%2C+Nancy+M%3BRosenheck%2C+Robert%3BRounsaville%2C+Bruce&rft.aulast=Drebing&rft.aufirst=Charles&rft.date=2007-01-01&rft.volume=44&rft.issue=6&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=Journal+of+rehabilitation+research+and+development&rft.issn=1938-1352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-07 N1 - Date created - 2007-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Brief alcohol interventions and multiple risk factors in primary care. AN - 69056589; 18077306 AB - Early identification and intervention of harmful/hazardous drinking in primary care are U.S. healthcare priorities. Traditionally, research has focused on designing interventions for patients in primary care who report hazardous/harmful alcohol use, even though it is likely for a patient to be at risk for multiple problems. This article has three major goals: (1) to present data highlighting the prevalence and co-variation of other risk factors with hazardous/harmful drinking, including data from a small descriptive study; (2) to review the literature on brief alcohol interventions designed to address multiple risk factors; and (3) to provide recommendations for future research. Despite data indicating primary care patients present with multiple risk factors, only a limited number of studies in the literature have investigated brief interventions addressing alcohol use and other risk factors. It is important for future research to expand brief alcohol interventions to include other risk factors as well. JF - Substance abuse AU - Funderburk, Jennifer S AU - Maisto, Stephen A AU - Sugarman, Dawn AD - Center for Integrated Healthcare, Syracuse VAMC, 800 Irving Ave 116C, Syracuse, NY 13210, USA. jennifer.funderburk@med.va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 93 EP - 105 VL - 28 IS - 4 SN - 0889-7077, 0889-7077 KW - Index Medicus KW - Goals KW - Risk Factors KW - Humans KW - Surveys and Questionnaires KW - Middle Aged KW - Male KW - Female KW - Prevalence KW - Alcohol-Related Disorders -- epidemiology KW - Alcoholism -- epidemiology KW - Alcoholism -- therapy KW - Primary Health Care -- methods KW - Psychotherapy, Brief UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69056589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=Brief+alcohol+interventions+and+multiple+risk+factors+in+primary+care.&rft.au=Funderburk%2C+Jennifer+S%3BMaisto%2C+Stephen+A%3BSugarman%2C+Dawn&rft.aulast=Funderburk&rft.aufirst=Jennifer&rft.date=2007-01-01&rft.volume=28&rft.issue=4&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of tiotropium in the treatment of COPD. AN - 68550154; 18044681 AB - Tiotropium is a potent, long-acting, selective anticholinergic bronchodilator. Treatment with tiotropium produces sustained improvements in lung function, particularly FEV1 (peak, trough, average, and area under the curve) compared with either placebo or ipratropium in patients with moderate to severe COPD. Preliminary evidence suggests that treatment with tiotropium may slow the rate of decline in FEV1, but this finding awaits confirmation. Tiotropium reduces lung hyperinflation, with associated improvements in exercise capacity. Tiotropium, compared with either placebo or ipratropium, improves a variety of patient-centered outcomes, including subjective dyspnea ratings and HRQL scores. Tiotropium reduces the frequency of COPD exacerbations and of hospitalizations due to exacerbations, but has not been shown to reduce all-cause mortality. Compared with the long-acting bronchodilators, tiotropium provides incrementally better bronchodilation, but it is not clearly superior in terms of patient-centered outcomes. Tiotropium has a good safety profile; however patients with severe cardiac disease, bladder outlet obstruction, or narrow angle glaucoma were excluded from all studies. Medico economic analyses suggest that treatment with tiotropium may also be cost-effective, primarily by reducing costs associated with hospitalizations. JF - International journal of chronic obstructive pulmonary disease AU - Rice, Kathryn L AU - Kunisaki, Ken M AU - Niewoehner, Dennis E AD - University of Minnesota, Minneapolis, MN, USA. kathryn.rice@va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 95 EP - 105 VL - 2 IS - 2 SN - 1176-9106, 1176-9106 KW - Adrenergic beta-Agonists KW - 0 KW - Bronchodilator Agents KW - Cholinergic Antagonists KW - Scopolamine Derivatives KW - Tiotropium Bromide KW - XX112XZP0J KW - Index Medicus KW - Respiratory Function Tests KW - Drug Therapy, Combination KW - Drug Costs KW - Humans KW - Cost-Benefit Analysis KW - Treatment Outcome KW - Clinical Trials as Topic KW - Exercise KW - Patient Selection KW - Adrenergic beta-Agonists -- therapeutic use KW - Forced Expiratory Volume -- drug effects KW - Scopolamine Derivatives -- therapeutic use KW - Scopolamine Derivatives -- economics KW - Bronchodilator Agents -- therapeutic use KW - Bronchodilator Agents -- economics KW - Scopolamine Derivatives -- adverse effects KW - Lung -- drug effects KW - Cholinergic Antagonists -- economics KW - Pulmonary Disease, Chronic Obstructive -- economics KW - Cholinergic Antagonists -- therapeutic use KW - Pulmonary Disease, Chronic Obstructive -- physiopathology KW - Pulmonary Disease, Chronic Obstructive -- drug therapy KW - Lung -- physiopathology KW - Cholinergic Antagonists -- adverse effects KW - Bronchodilator Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68550154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+chronic+obstructive+pulmonary+disease&rft.atitle=Role+of+tiotropium+in+the+treatment+of+COPD.&rft.au=Rice%2C+Kathryn+L%3BKunisaki%2C+Ken+M%3BNiewoehner%2C+Dennis+E&rft.aulast=Rice&rft.aufirst=Kathryn&rft.date=2007-01-01&rft.volume=2&rft.issue=2&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=International+journal+of+chronic+obstructive+pulmonary+disease&rft.issn=11769106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-18 N1 - Date created - 2007-11-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacotherapy. 2005 Dec;25(12):1708-18 [16305289] Eur Respir J. 2006 Mar;27(3):547-55 [16507855] Chest. 2006 Mar;129(3):509-17 [16537846] Proc Am Thorac Soc. 2006 May;3(3):239-44 [16636092] Pneumologie. 2006 Jun;60(6):341-6 [16761228] Respiration. 2006;73(4):420-7 [16484769] Chest. 2006 Dec;130(6):1695-703 [17166984] Ann Intern Med. 2007 Apr 17;146(8):545-55 [17310045] Pulm Pharmacol Ther. 2007;20(5):495-502 [16621638] Pulm Pharmacol Ther. 2007;20(6):627-8 [17005425] Am Rev Respir Dis. 1986 Jan;133(1):14-20 [3510578] Am J Physiol. 1992 Apr;262(4 Pt 1):L466-71 [1566862] Thorax. 1994 Jun;49(6):545-8 [8016790] JAMA. 1994 Nov 16;272(19):1497-505 [7966841] Am J Respir Crit Care Med. 1996 Mar;153(3):967-75 [8630581] JAMA. 2001 Feb 7;285(5):535-9 [11176854] J Aerosol Med. 2001 Fall;14(3):309-15 [11693842] Eur Respir J. 2002 Feb;19(2):209-16 [11871363] Eur Respir J. 2002 Feb;19(2):217-24 [11866001] Eur Respir J. 2002 Apr;19(4):639-44 [11998992] Am J Respir Crit Care Med. 2002 Aug 1;166(3):333-9 [12153966] Chest. 2000 Feb;117(2 Suppl):5S-9S [10673466] Chest. 2000 Feb;117(2 Suppl):63S-6S [10673478] Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1136-42 [10764302] Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1201-5 [10764312] Chest. 2000 Nov;118(5):1278-85 [11083675] Chest. 2000 Nov;118(5):1294-302 [11083677] Am J Respir Crit Care Med. 2002 Sep 1;166(5):675-9 [12204864] Life Sci. 2003 Mar 28;72(18-19):2121-6 [12628467] J Clin Epidemiol. 2003 Mar;56(3):248-55 [12725879] Thorax. 2003 May;58(5):399-404 [12728159] Chest. 2003 May;123(5):1441-9 [12740259] Chest. 2003 May;123(5):1684-92 [12740290] Ann Intern Med. 2003 Jun 17;138(12):969-73 [12809453] Can Respir J. 2003 May-Jun;10 Suppl A:11A-65A [12861361] Thorax. 2003 Oct;58(10):855-60 [14514937] Thorax. 2003 Nov;58(11):937-41 [14586043] JAMA. 2003 Nov 5;290(17):2301-12 [14600189] Chest. 2003 Nov;124(5):1743-8 [14605043] Pulm Pharmacol Ther. 2004;17(1):35-9 [14643169] J Clin Pharmacol. 2004 Feb;44(2):163-72 [14747425] Eur Respir J. 2004 Feb;23(2):241-9 [14979498] Thorax. 2004 Feb;59 Suppl 1:1-232 [15041752] Eur Respir J. 2004 Jun;23(6):825-31 [15218993] Eur Respir J. 2004 Jun;23(6):832-40 [15218994] Pharmacoeconomics. 2004;22(11):741-9 [15250751] Thorax. 1975 Oct;30(5):543-7 [1198394] Chest. 1984 Jun;85(6):751-8 [6723384] Chest. 1996 May;109(5):1163-8 [8625661] Am J Respir Crit Care Med. 1997 Apr;155(4):1283-9 [9105068] Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1557-65 [9817708] Respir Med. 2004 Dec;98(12):1214-21 [15588043] Pulm Pharmacol Ther. 2005;18(2):75-81 [15649848] Chest. 2005 Mar;127(3):809-17 [15764761] Cochrane Database Syst Rev. 2005;(2):CD002876 [15846642] Urologe A. 2005 Apr;44(4):393-5 [15672237] Eur Respir J. 2005 Aug;26(2):214-22 [16055868] Eur Respir J. 2005 Aug;26(2):319-38 [16055882] Chest. 2006 Jun;129(6):1693-708 [16778291] J Gen Intern Med. 2006 Oct;21(10):1011-9 [16970553] Am J Med. 2006 Oct;119(10 Suppl 1):12-20 [16996895] Am J Med. 2006 Oct;119(10 Suppl 1):63-72 [16996901] Thorax. 2006 Oct;61(10):854-62 [16844726] COPD. 2005 Mar;2(1):111-24 [17136971] Ann Intern Med. 2005 Sep 6;143(5):317-26 [16144890] Ann Intern Med. 2005 Sep 6;143(5):386-7 [16144897] Chest. 2005 Sep;128(3):1168-78 [16162703] Pulm Pharmacol Ther. 2005;18(6):397-404 [16179215] Proc Am Thorac Soc. 2005;2(4):297-304; discussion 311-2 [16267352] Comment In: Int J Chron Obstruct Pulmon Dis. 2007;2(2):93-4 [18046837] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic illness with complexities: mental illness and substance use among Veteran clinic users with diabetes. AN - 68489738; 17994477 AB - Create a taxonomy and examine the predictors of the often co-occurring conditions of substance use disorders and mental illness in veterans with diabetes. Merged Veteran Health Administration and Medicare fee-for-service claims data (N = 485,893). Thirty-one percent of patients with diabetes were diagnosed with either mental illness or substance use and had higher rates of diabetes-related complications. Women were more likely to have serious mental illness; African Americans and Latinos more likely to have drug and/or alcohol use. Prevalence of substance use disorder and mental illness differed by socio-demographics, suggesting the need for tailored diabetes management interventions. JF - The American journal of drug and alcohol abuse AU - Banerjea, Ranjana AU - Sambamoorthi, Usha AU - Smelson, David AU - Pogach, Leonard M AD - Department of Veterans Affairs New Jersey Healthcare System, Center for Health Care Knowledge Management, East Orange, New Jersey 07018, USA. Ranjana.Banerjea@va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 807 EP - 821 VL - 33 IS - 6 SN - 0095-2990, 0095-2990 KW - Index Medicus KW - United States KW - Sex Factors KW - Medicare -- statistics & numerical data KW - Humans KW - African Americans -- statistics & numerical data KW - Diagnosis, Dual (Psychiatry) KW - Aged KW - Comorbidity KW - Socioeconomic Factors KW - Hispanic Americans -- statistics & numerical data KW - Classification KW - Ethnic Groups KW - United States Department of Veterans Affairs KW - Adult KW - Population KW - Middle Aged KW - Chronic Disease KW - Female KW - Male KW - Veterans -- statistics & numerical data KW - Mental Disorders -- epidemiology KW - Mental Disorders -- classification KW - Diabetes Mellitus -- epidemiology KW - Substance-Related Disorders -- complications KW - Mental Disorders -- complications KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68489738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Chronic+illness+with+complexities%3A+mental+illness+and+substance+use+among+Veteran+clinic+users+with+diabetes.&rft.au=Banerjea%2C+Ranjana%3BSambamoorthi%2C+Usha%3BSmelson%2C+David%3BPogach%2C+Leonard+M&rft.aulast=Banerjea&rft.aufirst=Ranjana&rft.date=2007-01-01&rft.volume=33&rft.issue=6&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-16 N1 - Date created - 2007-11-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of NSAIDS on mortality and the effect of preexisting coronary artery disease in US veterans. AN - 68411126; 17208086 AB - Evidence indicates increased risk of cardiovascular events with certain nonsteroidal anti-inflammatory drug (NSAID) use; however, less is known about NSAID use and mortality. In addition, it is unclear whether risks observed with NSAIDs are modified by coronary artery disease (CAD). The association between NSAID exposure and mortality, cardiovascular, and cerebrovascular events was examined. A nested case-control study in a cohort of 565,451 US veterans with a diagnosis of osteoarthritis was conducted. The cohort was divided into those with preexisting CAD (16,869 cases) and those without (11,912 cases). Up to 20 controls were selected for each case. The average age of participants was 69.8 years (non-CAD) and 71.8 years (CAD). Relative to no exposure, adjusted odds ratios for cardiovascular or cerebrovascular events for any NSAID were 1.14 (95% confidence interval [CI], 1.08-1.21) in the non-CAD group and 1.18 (95% CI, 1.11-1.27) in the CAD group. Exposure to NSAIDs was associated with a decreased risk of all-cause mortality in both the non-CAD (0.72, 95% CI, 0.68-0.77) and CAD (0.79, 95% CI, 0.73-0.86) groups. As in previous reports, there was an increased risk of cardiovascular and cerebrovascular events for NSAIDs. However, NSAID exposure was associated with a reduced risk of death. This study raises important questions about NSAIDs in patients with osteoarthritis given that they seem to increase the risk of cardiovascular events but decrease overall mortality. JF - The American journal of medicine AU - Lee, Todd A AU - Bartle, Brian AU - Weiss, Kevin B AD - Midwest Center for Health Services and Policy Research, Hines Veterans Affairs Hospital, Chicago, Ill, USA. todd.lee@va.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 98.e9 EP - 16 VL - 120 IS - 1 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Veterans KW - Coronary Disease -- mortality KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Coronary Disease -- complications KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Osteoarthritis -- drug therapy KW - Coronary Disease -- chemically induced KW - Osteoarthritis -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68411126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Impact+of+NSAIDS+on+mortality+and+the+effect+of+preexisting+coronary+artery+disease+in+US+veterans.&rft.au=Lee%2C+Todd+A%3BBartle%2C+Brian%3BWeiss%2C+Kevin+B&rft.aulast=Lee&rft.aufirst=Todd&rft.date=2007-01-01&rft.volume=120&rft.issue=1&rft.spage=98.e9&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=1555-7162&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-08 N1 - Date created - 2007-01-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: ACP J Club. 2007 May-Jun;146(3):77 [17474686] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relative risk of glucose elevation during antipsychotic exposure in a Veterans Administration population. AN - 68370935; 17159454 AB - Concern is mounting that atypical antipsychotics cause disturbance in glucose regulation ranging from reversible hyperglycemia to diabetic ketoacidosis and death. It is difficult, however, to know what the level of risk of hyperglycemia might be for an individual patient on a particular medication of this class. We conducted a retrospective nonrandomized cohort analysis of glucose measurements in 18,764 patients receiving outpatient prescriptions for olanzapine, risperidone, or typical antipsychotics from 1 October 1998 to 30 June 2003 at six Veterans Affairs Medical Centers in the southeast United States. In patients without a random plasma glucose measurement > or =160 mg/dl before medication exposure (n=1394), treatment with index medications was associated with an incidence of new diabetes-level hyperglycemia of 78.7 cases per 1,000 individuals exposed per year. Olanzapine exposure was associated with a greater rate of developing at least one glucose measurement > or =200 mg/dl than risperidone (odds ratio=2.14, P=0.003). Olanzapine exposure was also associated with a greater rate of development of at least one fasting glucose measurement > or =126 mg/dl than risperidone. Typical antipsychotics were associated with risk intermediate between the two atypicals. These data indicate that patients with no previously observed glucose elevations develop diabetes-level hyperglycemia during antipsychotic treatment, particularly in patients receiving olanzapine. JF - International clinical psychopharmacology AU - Duncan, Erica AU - Dunlop, Boadie W AU - Boshoven, William AU - Woolson, Sandra L AU - Hamer, Robert M AU - Phillips, Lawrence S AD - Mental Health Service, Atlanta VA Medical Center, Decatur GA 30033, USA. erica.duncan@va.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 1 EP - 11 VL - 22 IS - 1 SN - 0268-1315, 0268-1315 KW - Antipsychotic Agents KW - 0 KW - Blood Glucose KW - Benzodiazepines KW - 12794-10-4 KW - Perphenazine KW - FTA7XXY4EZ KW - Haloperidol KW - J6292F8L3D KW - Risperidone KW - L6UH7ZF8HC KW - olanzapine KW - N7U69T4SZR KW - Fluphenazine KW - S79426A41Z KW - Chlorpromazine KW - U42B7VYA4P KW - Index Medicus KW - Haloperidol -- adverse effects KW - Fluphenazine -- adverse effects KW - Southeastern United States -- epidemiology KW - Humans KW - Retrospective Studies KW - Risk Assessment KW - Chlorpromazine -- adverse effects KW - Perphenazine -- adverse effects KW - Benzodiazepines -- adverse effects KW - Risk Factors KW - Cohort Studies KW - Incidence KW - Middle Aged KW - Risperidone -- adverse effects KW - Time Factors KW - Female KW - Male KW - Hospitals, Veterans KW - Veterans KW - Hyperglycemia -- epidemiology KW - Hyperglycemia -- chemically induced KW - Blood Glucose -- drug effects KW - Antipsychotic Agents -- adverse effects KW - Hyperglycemia -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68370935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+clinical+psychopharmacology&rft.atitle=Relative+risk+of+glucose+elevation+during+antipsychotic+exposure+in+a+Veterans+Administration+population.&rft.au=Duncan%2C+Erica%3BDunlop%2C+Boadie+W%3BBoshoven%2C+William%3BWoolson%2C+Sandra+L%3BHamer%2C+Robert+M%3BPhillips%2C+Lawrence+S&rft.aulast=Duncan&rft.aufirst=Erica&rft.date=2007-01-01&rft.volume=22&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=International+clinical+psychopharmacology&rft.issn=02681315&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-02 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nurses' perceptions of causes of medication errors and barriers to reporting. AN - 68367703; 17149082 AB - This study describes nurses' perceptions about medication errors and the effects of physician order entry and barcode medication administration on medication errors. A convenience sample of 61 medical-surgical nurses was surveyed. All nurses surveyed perceived that information technology decreases medication errors. However, medication errors continue to occur despite the availability of sophisticated information technology systems. JF - Journal of nursing care quality AU - Ulanimo, Virginia M AU - O'Leary-Kelley, Colleen AU - Connolly, Phyllis M AD - VAPAHCS, Palo Alto, CA 94304, USA. virginia.ulanimo@va.gov PY - 2007 SP - 28 EP - 33 VL - 22 IS - 1 SN - 1057-3631, 1057-3631 KW - Index Medicus KW - Nursing KW - Humans KW - Medical Staff, Hospital KW - Quality Assurance, Health Care KW - Nursing Staff, Hospital -- psychology KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Medical Errors -- nursing KW - Nursing Staff, Hospital -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68367703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nursing+care+quality&rft.atitle=Nurses%27+perceptions+of+causes+of+medication+errors+and+barriers+to+reporting.&rft.au=Ulanimo%2C+Virginia+M%3BO%27Leary-Kelley%2C+Colleen%3BConnolly%2C+Phyllis+M&rft.aulast=Ulanimo&rft.aufirst=Virginia&rft.date=2007-01-01&rft.volume=22&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Journal+of+nursing+care+quality&rft.issn=10573631&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-06 N1 - Date created - 2006-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Personal and treatment-related predictors of abstinence self-efficacy. AN - 68360937; 17149526 AB - To understand better the relationship between substance-use disorder treatment and abstinence self-efficacy, more information is needed about what factors predict greater abstinence self-efficacy. Participants (n = 2,350) from 88 community residential facilities were assessed at treatment entry and 1-year follow-up. Treatment providers reported on patients' engagement in specific components of treatment. After examining univariate associations with self-efficacy, a multiple regression analysis was used to test a model of patient- and treatment-related predictors of self-efficacy 1 year after treatment. More years of education, lower baseline substance- related problems, and higher baseline confidence in abstinence were associated with higher posttreatment self-efficacy. After controlling for these patient factors, patients who were more engaged in skills-training activities and who inspired providers' confidence in their ability to remain abstinent had higher 1-year self-efficacy. The development of higher levels of posttreatment abstinence self-efficacy is driven not only by what a patient brings to treatment but by the activities a patient engages in during treatment. Because of the close relationship between self-efficacy and treatment outcomes, providers may want to target patients with low self- efficacy for interventions that focus on skills-training techniques. JF - Journal of studies on alcohol and drugs AU - Ilgen, Mark AU - McKellar, John AU - Moos, Rudolf AD - Center for Health Care Evaluation, Department of Veterans Affairs Palo Alto Health Care System and Stanford University School of Medicine, 795 Willow Road (MPD 152), Menlo Park, California 94025, USA. Mark.Ilgen@med.va.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 126 EP - 132 VL - 68 IS - 1 SN - 1937-1888, 1937-1888 KW - Index Medicus KW - Severity of Illness Index KW - Mental Disorders -- diagnosis KW - Recreation -- psychology KW - Mental Disorders -- epidemiology KW - Humans KW - Interpersonal Relations KW - Adult KW - Surveys and Questionnaires KW - Social Behavior KW - Follow-Up Studies KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Attitude to Health KW - Self Efficacy KW - Temperance KW - Alcoholism -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68360937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol+and+drugs&rft.atitle=Personal+and+treatment-related+predictors+of+abstinence+self-efficacy.&rft.au=Ilgen%2C+Mark%3BMcKellar%2C+John%3BMoos%2C+Rudolf&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2007-01-01&rft.volume=68&rft.issue=1&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol+and+drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-29 N1 - Date created - 2006-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Microstimulators and intramuscular hook electrodes for the stimulation of respiratory muscles. AN - 68267765; 17853655 AB - We determined the feasibility of stimulating the major muscles of respiration with different types of electrodes. Intramuscular hook electrodes, model microstimulators (M-Micro) developed in our laboratory, and commercial radiofrequency microstimulators (RFM) (Alfred Mann Foundation, Valencia, CA), were employed in this investigation. In 8 anesthetized dogs, M-Micro were placed bilaterally on the diaphragm and in the abdominal muscles, and hook electrodes were placed in the 3rd and 5th intercostal regions adjacent to the intercostal nerves known to support inspiration. In 3 of the 8 animals, RFMs (Alfred Mann Foundation) in addition to the M-Micros were sutured to each hemidiaphragm at the same optimal site for phrenic nerve stimulation. During a hyperventilation-induced apnea, 2-second stimulations were applied to the diaphragm and with various combinations of diaphragm plus supporting muscles, both thoracic and abdominal. Diaphragm stimulation alone provided tidal volumes adequate for basal alveolar ventilation. However, implantation of the RFM required greater contact with the muscle. Stimulating other respiratory muscles along with the diaphragm further increased tidal volumes. The hook electrodes, M-Micro, and RFM performed equally well. In the acute dog model, M-Micro and hook electrodes can provide an implant system for the maintenance of ventilation. Support of the intercostal and abdominal muscles has the potential to reduce the contraction requirements of the diaphragm with decreased likelihood of diaphragm fatigue and hypoventilation. Whether the electrodes under investigation could provide an implant system for long-term ventilation needs to be determined. JF - The journal of spinal cord medicine AU - Walter, James S AU - Dunn, Robert B AU - Wurster, Robert D AU - Laghi, Franco AD - Research Service, Hines Veterans Administration Hospital, Hines, Illinois 60141, USA. james.walter@med.va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 338 EP - 345 VL - 30 IS - 4 SN - 1079-0268, 1079-0268 KW - Index Medicus KW - Animals KW - Intercostal Muscles -- radiation effects KW - Diaphragm -- physiology KW - Diaphragm -- radiation effects KW - Dogs KW - Respiration, Artificial KW - Phrenic Nerve -- physiology KW - Intercostal Muscles -- physiology KW - Dose-Response Relationship, Radiation KW - Tidal Volume KW - Electric Stimulation -- methods KW - Electrodes, Implanted KW - Respiratory Muscles -- radiation effects KW - Electric Stimulation -- instrumentation KW - Respiratory Muscles -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68267765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+spinal+cord+medicine&rft.atitle=Microstimulators+and+intramuscular+hook+electrodes+for+the+stimulation+of+respiratory+muscles.&rft.au=Walter%2C+James+S%3BDunn%2C+Robert+B%3BWurster%2C+Robert+D%3BLaghi%2C+Franco&rft.aulast=Walter&rft.aufirst=James&rft.date=2007-01-01&rft.volume=30&rft.issue=4&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=The+journal+of+spinal+cord+medicine&rft.issn=10790268&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-26 N1 - Date created - 2007-09-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Phys Med Rehabil. 1999 Nov;80(11):1411-9 [10569435] J Rehabil Res Dev. 2001 Sep-Oct;38(5):591-7 [11732836] Am J Respir Crit Care Med. 2003 Jul 1;168(1):10-48 [12826594] Arch Phys Med Rehabil. 1966 Nov;47(11):705-10 [5332775] Pacing Clin Electrophysiol. 1986 Nov;9(6 Pt 1):780-4 [2432480] Am Rev Respir Dis. 1987 Dec;136(6):1385-90 [3688644] Chest. 2005 Feb;127(2):671-8 [15706014] J Thorac Cardiovasc Surg. 1990 Jan;99(1):35-9; discussion 39-40 [2294363] Arch Phys Med Rehabil. 1990 Jun;71(7):495-9 [2350219] Pacing Clin Electrophysiol. 1990 Aug;13(8):1061-72 [1697953] Arch Phys Med Rehabil. 1995 Mar;76(3):266-71 [7717821] IEEE Trans Rehabil Eng. 1996 Mar;4(1):1-6 [8798066] J Clin Neurophysiol. 1997 Sep;14(5):369-77 [9415384] J Appl Physiol (1985). 1989 Oct;67(4):1395-400 [2793741] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Where do people go when they first become homeless? A survey of homeless adults in the USA AN - 61671191; 200811524 AB - The longer a person is homeless, the more likely he or she is to experience poor health and be placed at higher risk for premature death. This makes interventions early in one's homelessness an important prevention strategy. However, little is known about where someone goes for help when they first become homeless and how well those sites are prepared to address the multitude of issues facing a homeless person. In order to address this question, we conducted a cross-sectional community-based survey in two US cities in 1997 using population proportionate sampling of homeless persons identified at 91 sites to identify 'first-stop' access sites and reasons for seeking help at those sites. A total of 230 persons participated in the face-to-face interview (93% response rate). From a list of 20 possible 'first-stop' sites, 105 (45.7%) reported going to a soup kitchen, 71 (30.9%) went to a welfare office, 64 (27.8%) sought admission to a detoxification centre, 60 (26.1%) met with a homeless outreach team, 57 (24.8%) went to a family member, and 54 (23.5%) went to an emergency room. Individuals with a chronic medical or mental health condition were significantly more likely to access a healthcare site (medical: 62.6% vs. 47.6%, P =0.02; mental health: 62.4% vs. 38.8%, P <0.01) or social service agency (medical: 64.0% vs. 43.3%, P =0.02; mental health: 59.1% vs. 40.7%, P <0.01). Those persons reporting a need for alcohol treatment were significantly more likely to first go to a healthcare site (46.4% vs. 29.1%, P <0.01) and those with alcohol abuse/dependence were less likely to seek help from family or friends (66.7% vs. 81.9%, P <0.01). Most respondents sought assistance for concerns directly associated with an immediate need as opposed to seeking care for issues causing their actual homelessness. These findings suggest the need to expand and integrate the availability of services at 'first-stop' access sites that facilitate early exits from homelessness. Adapted from the source document. JF - Health & Social Care in the Community AU - O'Toole, Thomas P AU - Conde-Martel, Alicia AU - Gibbon, Jeanette L AU - Hanusa, Barbara H AU - Freyder, Paul J AU - Fine, Michael J AD - Brown Medical School and the Providence VA Medical Center, Rhode Island, USA thomas.o'toole@va.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 446 EP - 453 PB - Blackwell Publishing, Oxford UK VL - 15 IS - 5 SN - 0966-0410, 0966-0410 KW - Detoxification KW - Alcohol Abuse KW - Help Seeking Behavior KW - Social Services KW - Family Violence KW - United States of America KW - Access KW - Homelessness KW - article KW - 2793: studies in poverty; homelessness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61671191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+%26+Social+Care+in+the+Community&rft.atitle=Where+do+people+go+when+they+first+become+homeless%3F+A+survey+of+homeless+adults+in+the+USA&rft.au=O%27Toole%2C+Thomas+P%3BConde-Martel%2C+Alicia%3BGibbon%2C+Jeanette+L%3BHanusa%2C+Barbara+H%3BFreyder%2C+Paul+J%3BFine%2C+Michael+J&rft.aulast=O%27Toole&rft.aufirst=Thomas&rft.date=2007-01-01&rft.volume=15&rft.issue=5&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Health+%26+Social+Care+in+the+Community&rft.issn=09660410&rft_id=info:doi/10.1111%2Fj.1365-2524.2007.00703.x LA - English DB - Sociological Abstracts N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-28 N1 - CODEN - HSCCEL N1 - SubjectsTermNotLitGenreText - Homelessness; United States of America; Detoxification; Help Seeking Behavior; Access; Alcohol Abuse; Social Services; Family Violence DO - http://dx.doi.org/10.1111/j.1365-2524.2007.00703.x ER - TY - JOUR T1 - The Working Alliance in Intervention for Partner Violence Perpetrators: Recent Research and Theory AN - 61644456; 200720821 AB - The working alliance consists of therapist and client agreement on the goals and tasks of therapy, and the therapeutic bond. Measures of the working alliance, assessed during the course of therapy, have consistently predicted positive therapeutic change across various client populations and treatment approaches. This paper reviews recent research highlighting the importance of the working alliance with respect to treatment compliance and outcome in interventions for perpetrators of partner violence. The common promotion and use of confrontational intervention tactics in these interventions and the potentially negative impact of confrontational tactics on the working alliance is also discussed. Adapted from the source document. JF - Journal of Family Violence AU - Taft, Casey T AU - Murphy, Christopher M AD - National Center for PTSD, VA Boston Healthcare System, and Boston University School of Medicine, 150 South Huntington Avenue, Boston, MA 02130, USA E-mail: casey.taft@va.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 11 EP - 18 PB - Springer Science+Business Media, Inc, New York, NY VL - 22 IS - 1 SN - 0885-7482, 0885-7482 KW - Working alliance, Partner violence, Confrontation, Abuser intervention KW - Therapists KW - Client Relations KW - Partner Abuse KW - Treatment Compliance KW - article KW - 2190: social problems and social welfare; victimology (rape, family violence, & child abuse) KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61644456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Violence&rft.atitle=The+Working+Alliance+in+Intervention+for+Partner+Violence+Perpetrators%3A+Recent+Research+and+Theory&rft.au=Taft%2C+Casey+T%3BMurphy%2C+Christopher+M&rft.aulast=Taft&rft.aufirst=Casey&rft.date=2007-01-01&rft.volume=22&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Violence&rft.issn=08857482&rft_id=info:doi/10.1007%2Fs10896-006-9053-z LA - English DB - Sociological Abstracts N1 - Date revised - 2007-08-31 N1 - Number of references - 61 N1 - Last updated - 2016-09-28 N1 - CODEN - JFVIEV N1 - SubjectsTermNotLitGenreText - Partner Abuse; Treatment Compliance; Client Relations; Therapists DO - http://dx.doi.org/10.1007/s10896-006-9053-z ER - TY - JOUR T1 - Services to Patients with Dual Diagnoses: Findings from Washington's Mental Health Service System AN - 61425521; 200802264 AB - This study examined how Washington State's (WA) mental health treatment system provided services to patients with substance use disorders or dual diagnoses at several stages of care: crisis commitment, hospitalization, and outpatient treatment. A total of 30 key informants from urban and rural areas were surveyed between February and July 2004 using semi-structured interviews. Key informants represented direct service providers to chief operating officers. Themes, consensus, and disagreements were summarized. Results indicated that best practices are not consistently implemented and administrative and provider barriers hinder provision of more effective care. Findings highlight that work on how to best implement evidence-based practices is critical to improving care of dual diagnosis patients. Limitations of the study are noted as well as future research directions. Adapted from the source document. JF - Substance Use & Misuse AU - Ouimette, Paige AU - Jemelka, Ron AU - Hall, Judy AU - Brimner, Karl AU - Krupski, Antoinette AU - Stark, Kenneth AD - Syracuse VA Medical Center, 800 Irving Ave (116c), Syracuse, NY 13210 E-mail: paigec.ouimette@med.va.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 113 EP - 127 PB - Taylor & Francis, Philadelphia PA VL - 42 IS - 1 SN - 1082-6084, 1082-6084 KW - dual diagnosis, substance use disorders, public treatment system, best practices, barriers to care KW - Outpatients KW - Substance Abuse KW - Hospitalization KW - Delivery Systems KW - Evidence Based Practice KW - Mental Health Services KW - Comorbidity KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61425521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=Services+to+Patients+with+Dual+Diagnoses%3A+Findings+from+Washington%27s+Mental+Health+Service+System&rft.au=Ouimette%2C+Paige%3BJemelka%2C+Ron%3BHall%2C+Judy%3BBrimner%2C+Karl%3BKrupski%2C+Antoinette%3BStark%2C+Kenneth&rft.aulast=Ouimette&rft.aufirst=Paige&rft.date=2007-01-01&rft.volume=42&rft.issue=1&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.1080%2F10826080601096657 LA - English DB - Social Services Abstracts N1 - Date revised - 2008-04-02 N1 - Number of references - 30 N1 - Last updated - 2016-09-28 N1 - CODEN - SUMIFL N1 - SubjectsTermNotLitGenreText - Substance Abuse; Mental Health Services; Comorbidity; Delivery Systems; Hospitalization; Outpatients; Evidence Based Practice DO - http://dx.doi.org/10.1080/10826080601096657 ER - TY - JOUR T1 - The Development of Palliative Care Programs in the Veterans Administration: Zelda Foster's Legacy AN - 61409709; 200805799 AB - The U.S. Department of Veterans Affairs (VA) has been a leader in program development & service delivery in the areas of geriatrics, hospice & palliative care for decades. Zelda Foster, MSW, serving as the Chief of Social Work Services at the Brooklyn VA Hospital for almost 20 years, was a force in the early days of the palliative care & hospice movement in the United States, publishing a seminal article in 1965, & contributing through educational initiatives, program development, information dissemination & mentorship of countless social workers. With an early recognition of the demographic imperative of aging veterans, the VA established a number of innovative programs which have been widely replicated outside of the VA. Zelda Foster was a central figure in the evolution of these programs & a strong & effective advocate for the inclusion of social workers. She deserves much credit for the fact that social workers are now centrally involved in an array of leadership activities in palliative & end-of-life care both within & outside of VA. Tables, References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Social Work in End-of-Life & Palliative Care AU - Daratsos, Louisa AU - Howe, Judith L AD - VA New York Harbor Health Care System Brooklyn Campus louisa.daratsos@va.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 29 EP - 39 PB - The Haworth Press, Inc. VL - 3 IS - 1 SN - 1552-4256, 1552-4256 KW - Social work, palliative and end-of-life care, veterans, geriatrics, Veterans Administration, education and training KW - Veterans KW - Education KW - Training KW - Palliative Care KW - Social Work KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61409709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+Work+in+End-of-Life+%26+Palliative+Care&rft.atitle=The+Development+of+Palliative+Care+Programs+in+the+Veterans+Administration%3A+Zelda+Foster%27s+Legacy&rft.au=Daratsos%2C+Louisa%3BHowe%2C+Judith+L&rft.aulast=Daratsos&rft.aufirst=Louisa&rft.date=2007-01-01&rft.volume=3&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+Work+in+End-of-Life+%26+Palliative+Care&rft.issn=15524256&rft_id=info:doi/10.1300%2FJ457v03n01_05 LA - English DB - Social Services Abstracts N1 - Date revised - 2008-11-06 N1 - Number of references - 9 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Veterans; Education; Training; Palliative Care; Social Work DO - http://dx.doi.org/10.1300/J457v03n01_05 ER - TY - JOUR T1 - Zelda Foster: A Social Work Mentor's Legacy AN - 61400719; 200805632 AB - The authors draw on their personal & professional experiences working with the late social worker Zelda Foster (1934-2006) at the Veteran's Administration (VA) in Brooklyn, NY, to describe her skills as a mentor. In-depth interview data obtained from 6 senior-level social work managers at the VA are drawn on to demonstrate how she helped so many in terms of fostering leadership, critical thinking, networking, ethical practice, & personal & professional growth. Characteristics of an effective mentor are delineated. Figures. K. Hyatt Stewart JF - Journal of Social Work in End-of-Life & Palliative Care AU - Howe, Judith L AU - Daratsos, Louisa AD - Mount Sinai School Medicine Judith.howe@va.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 47 EP - 56 PB - The Haworth Press, Inc. VL - 3 IS - 1 SN - 1552-4256, 1552-4256 KW - Veterans KW - New York City, New York KW - Social Workers KW - Leadership KW - article KW - 6111: social work theory/research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61400719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+Work+in+End-of-Life+%26+Palliative+Care&rft.atitle=Zelda+Foster%3A+A+Social+Work+Mentor%27s+Legacy&rft.au=Howe%2C+Judith+L%3BDaratsos%2C+Louisa&rft.aulast=Howe&rft.aufirst=Judith&rft.date=2007-01-01&rft.volume=3&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+Work+in+End-of-Life+%26+Palliative+Care&rft.issn=15524256&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2008-11-06 N1 - Number of references - 11 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Leadership; Social Workers; Veterans; New York City, New York ER - TY - JOUR T1 - Advancing Evidence-Based Care For Diabetes: Lessons From The Veterans Health Administration AN - 58765913; 2007-16681 AB - The Veterans Health Administration (VHA) is a unique laboratory for using the electronic health record (EHR) to transform health care and accelerate discovery. This is particularly evident in the care of veterans with diabetes, who constitute a quarter of those served by the VHA. Although EHRs have enabled rapid learning, additional factors were necessary, including the lead participation of clinician-investigators, accountability through performance measurement, a delivery system focused on population health, and favorable economic externalities. "Off-the-shelf" technology is unlikely to generate similar benefits if these attributes are not in place. Adapted from the source document. JF - Health Affairs AU - Kupersmith, Joel AU - Francis, Joseph AU - Kerr, Eve AU - Krein, Sarah AU - Pogach, Leonard AU - Kolodner, Robert M AU - Perlin, Jonathan B AD - Department of Veterans Affairs (VA), Washington, D.C. E-mail: Joel.Kupersmith@va.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - w156 EP - w168 PB - Project HOPE, Bethesda MD IS - Supplement SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Medicine and health care KW - Military and defense policy - Military personnel and veterans KW - Veterans - Medical care KW - United States - Veterans administration KW - Medical records - Information processing systems KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58765913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Advancing+Evidence-Based+Care+For+Diabetes%3A+Lessons+From+The+Veterans+Health+Administration&rft.au=Kupersmith%2C+Joel%3BFrancis%2C+Joseph%3BKerr%2C+Eve%3BKrein%2C+Sarah%3BPogach%2C+Leonard%3BKolodner%2C+Robert+M%3BPerlin%2C+Jonathan+B&rft.aulast=Kupersmith&rft.aufirst=Joel&rft.date=2007-01-01&rft.volume=&rft.issue=Supplement&rft.spage=w156&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.26.2.w156 LA - English DB - PAIS Index N1 - Date revised - 2007-08-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medical records - Information processing systems; United States - Veterans administration; Veterans - Medical care DO - http://dx.doi.org/10.1377/hlthaff.26.2.w156 ER - TY - JOUR T1 - Medicine and Industry: a necessary but conflicted relationship AN - 58748359; 2007-10006 AB - Medicine and industry are bound together by mutual needs. The development and utilization of new drugs and medical devices requires both the scientific and clinical expertise of physicians, and the resources and entrepreneurial ethos of business. The medicine-industry partnership has contributed to dramatic improvements in medical care. The increasing influence of the pharmaceutical and medical equipment industry in medicine has, however, raised concerns about costs and regulation, as well as about medicine's traditional independence and objectivity. Some critics feel that the fundamental obligation of business to provide profit for shareholders conflicts with physicians' traditional role as disinterested advocates of patients' interests. Nonetheless, with about 15% of the U.S. economy now devoted to health care, an ongoing and robust relation between business and medicine seems inevitable. A mutually productive relationship between medicine and industry is essential for continued innovation and improvement in health care. Continuous and open dialogue, such as that in the following articles, is necessary to resolve conflicts and achieve this goal. Adapted from the source document. JF - Perspectives in Biology and Medicine AU - Fisher, Morris A AD - Hines VA Hospital, IL E-mail: morris.fisher@med.va.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 1 EP - 6 PB - John Hopkins University Press, Baltimore MD VL - 50 IS - 1 SN - 0031-5982, 0031-5982 KW - Labor conditions and policy - Occupational health and safety KW - Health conditions and policy - Medicine and health care KW - Manufacturing and heavy industry - Industry and industrial policy KW - Industrial medicine KW - Medicine KW - Industry KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58748359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+Biology+and+Medicine&rft.atitle=Medicine+and+Industry%3A+a+necessary+but+conflicted+relationship&rft.au=Fisher%2C+Morris+A&rft.aulast=Fisher&rft.aufirst=Morris&rft.date=2007-01-01&rft.volume=50&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+Biology+and+Medicine&rft.issn=00315982&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2007-06-19 N1 - Last updated - 2016-09-28 N1 - CODEN - PBMEA8 N1 - SubjectsTermNotLitGenreText - Industrial medicine; Medicine; Industry ER - TY - JOUR T1 - Get copyright right: a collection of copyright corner columns from SLA's iInformation Outlook/i, updated for 2006. AN - 57704946; 200800243 AB - Book review abstract. Get Copyright Right: A Collection of Copyright Corner Columns from SLA's Information Outlook, Updated for 2006. By Laura N. Gasaway. Alexandria, VA: Special Libraries Association, 2006, 146pp., 29.95 USD. ISBN: 978-0-87111555-7. Reviewed by Priscilla Stephenson. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Stephenson, Priscilla AU - Stephenson, Priscilla AD - Medical Library, G. V 'Sonny' Montgomery VA Medical Center, Jackson, MS priscilla.stephenson@va.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 466 PB - Medical Library Association, Chicago, IL VL - 95 IS - 4 SN - 1536-5050, 1536-5050 KW - Libraries KW - Copyright KW - article KW - 1.11: BOOK REVIEWS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57704946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Get+copyright+right%3A+a+collection+of+copyright+corner+columns+from+SLA%27s+iInformation+Outlook%2Fi%2C+updated+for+2006.&rft.au=Stephenson%2C+Priscilla&rft.aulast=Stephenson&rft.aufirst=Priscilla&rft.date=2007-01-01&rft.volume=95&rft.issue=4&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/10.3163%2F1536-5050.95.4.466 L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Copyright; Libraries DO - http://dx.doi.org/10.3163/1536-5050.95.4.466 ER - TY - JOUR T1 - Gulf War Syndrome: information from the Internet AN - 57692701; 200805832 AB - The existence of Gulf War Syndrome is a topic of much controversy. Many highly respected scientists initially concluded that no single disease or unique condition affected the veterans of the Gulf War. More recent studies have concluded that there is evidence that some of the conditions suffered by many Gulf War veterans are more common among those who served in the Gulf and are, quite likely, a result of exposure to toxins, whether man-made or naturally occurring, that were present in the area of the Gulf War. This article provides general information on Gulf War Syndrome, controversy surrounding the syndrome, and challenges faced in determining whether the syndrome exists. A bibliography of selected Internet resources provides additional information on the syndrome. Adapted from the source document. JF - Journal of Consumer Health on the Internet AU - Taylor, Mary Virginia AD - VA Medical Center at Memphis, 1030 Jefferson Avenue, Memphis, TN 38104 maryvirginia.taylor@va.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 49 EP - 60 PB - Haworth Press, Binghamton NY VL - 11 IS - 1 SN - 1539-8285, 1539-8285 KW - Gulf War Syndrome, Gulf War, Persian Gulf Syndrome, veterans KW - Gulf War Syndrome KW - War KW - Diseases KW - Consumer health information KW - article KW - 10.14: INFORMATION SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57692701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consumer+Health+on+the+Internet&rft.atitle=Gulf+War+Syndrome%3A+information+from+the+Internet&rft.au=Taylor%2C+Mary+Virginia&rft.aulast=Taylor&rft.aufirst=Mary&rft.date=2007-01-01&rft.volume=11&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consumer+Health+on+the+Internet&rft.issn=15398285&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-09-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Consumer health information; Diseases; War; Gulf War Syndrome ER - TY - JOUR T1 - Gender differences in colorectal cancer screening barriers and information needs AN - 57233145; 200809946 AB - Context: Several prior studies have found that women are less likely to be screened for colorectal cancer (CRC) than men. While the source of this screening differential is unknown, recent studies suggest gender differences in barriers to screening might explain the disparity. Objective: This formative study was designed to explore CRC screening barriers, attitudes and preferences by gender. Methodology: Focus group interviews with groups stratified by gender and screening status. Participants included 27 females and 43 males between the ages of 50 and 75 years who receive primary care at the Minneapolis VA Medical Center. We conducted interpretive and grounded text analysis of semi-structured focus group interviews to assess how knowledge, experiences and sociocultural norms shape female and male preferences and barriers to current CRC screening guidelines. Results: Female and male participants reported similar preferences for CRC screening mode, but there were notable differences in the barriers and facilitators to screening. Key findings suggest that women viewed the preparation for endoscopic procedures as a major barrier to screening while men did not; women and men expressed different fears and information preferences regarding endoscopic procedures; and women perceive CRC as a male disease thus feeling less vulnerable to CRC. Gender-specific barriers may explain women's lower rate of screening for CRC. Conclusion: Colorectal cancer screening promotion interventions, decision aids and clinical practice may benefit by being tailored by gender. Adapted from the source document. JF - Health Expectations AU - Friedemann-Sanchez, Greta AU - Griffin, Joan M AU - Partin, Melissa R AD - Investigator at the Center for Chronic Disease Outcomes Research, Minneapolis VA Medical Center, Minneapolis, MN greta.friedemann-sanchez@med.va.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 148 EP - 160 PB - Blackwell Publishing, Oxford UK VL - 10 IS - 2 SN - 1369-6513, 1369-6513 KW - Screening KW - Preferences KW - Men KW - Gender KW - Women KW - Colorectal cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57233145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Expectations&rft.atitle=Gender+differences+in+colorectal+cancer+screening+barriers+and+information+needs&rft.au=Friedemann-Sanchez%2C+Greta%3BGriffin%2C+Joan+M%3BPartin%2C+Melissa+R&rft.aulast=Friedemann-Sanchez&rft.aufirst=Greta&rft.date=2007-01-01&rft.volume=10&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Health+Expectations&rft.issn=13696513&rft_id=info:doi/10.1111%2Fj.1369-7625.2006.00430.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - HEHPFM N1 - SubjectsTermNotLitGenreText - Screening; Men; Women; Preferences; Gender; Colorectal cancer DO - http://dx.doi.org/10.1111/j.1369-7625.2006.00430.x ER - TY - JOUR T1 - Contributions to the Dimensional Assessment of Personality Disorders Using Millon's Model and the Millon Clinical Multiaxial Inventory (MCMI9-III) AN - 57228001; 200805251 AB - For over 35 years, Millon's (1996) model of personality and the Millon Clinical Multiaxial Inventory (Millon, 1977, 1987, 2006) have been useful resources for clinicians to understand and assess personality disorders (PDs) and clinical syndromes in psychiatric patients. In this article, we highlight significant features of the model and test that have proved valuable to personologists in their quest for a more satisfactory taxonomy of PDs based on continuously distributed traits. We also describe Millon's (1996)prototypal domain approach to personality that combines dimensional and categorical elements for the description of PDs and their normal counterparts. Adapted from the source document. JF - Journal of Personality Assessment AU - Strack, Stephen AU - Millon, Theodore AD - U.S. Department of Veterans Affairs, Ambulatory Care Center, Los Angeles, California Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 56 EP - 69 PB - Lawrence Erlbaum Associates, Mahwah NJ VL - 89 IS - 1 SN - 0022-3891, 0022-3891 KW - Diagnosis KW - Classification KW - Measures KW - Diagnostic systems KW - Personality disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57228001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+Assessment&rft.atitle=Contributions+to+the+Dimensional+Assessment+of+Personality+Disorders+Using+Millon%27s+Model+and+the+Millon+Clinical+Multiaxial+Inventory+%28MCMI9-III%29&rft.au=Strack%2C+Stephen%3BMillon%2C+Theodore&rft.aulast=Strack&rft.aufirst=Stephen&rft.date=2007-01-01&rft.volume=89&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+Assessment&rft.issn=00223891&rft_id=info:doi/10.1080%2F00223890701357217 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - JNPABU N1 - SubjectsTermNotLitGenreText - Personality disorders; Measures; Diagnosis; Classification; Diagnostic systems DO - http://dx.doi.org/10.1080/00223890701357217 ER - TY - JOUR T1 - Metaphor Shifts in Stroke Recovery AN - 57217403; 200803684 AB - An illness event like stroke is generally believed to produce a biographical disruption in the individual, resulting in a reconstruction of one's self identity. One method of narrative reconstruction is the use of personal metaphor. Although previous research has illustrated a variety of illness metaphors, including that of war, there has been little research conducted on how these metaphors shift throughout a person's recovery period. The authors present data that indicate an intricate connection exists among changes in individuals' physical functioning, self-reported depression level, self-identity, and the metaphors they use to describe the stroke and stroke recovery experience. As the metaphor one uses to describe one's stroke experience shifts, so does one's sense of self. As one's self-identity changes, one's level of self-reported depression may also increase. Adapted from the source document. JF - Health Communication AU - Boylstein, Craig AU - Rittman, Maude AU - Hinojosa, Ramon AD - Rehabilitation Outcomes Research Center North Florida/South Georgia Veterans Administration Center Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 279 EP - 287 PB - Lawrence Erlbaum Associates, Mahwah NJ VL - 21 IS - 3 SN - 1041-0236, 1041-0236 KW - Depression KW - Reconstruction KW - Recovery KW - Strokes KW - Sense of self KW - Metaphors KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57217403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Communication&rft.atitle=Metaphor+Shifts+in+Stroke+Recovery&rft.au=Boylstein%2C+Craig%3BRittman%2C+Maude%3BHinojosa%2C+Ramon&rft.aulast=Boylstein&rft.aufirst=Craig&rft.date=2007-01-01&rft.volume=21&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Health+Communication&rft.issn=10410236&rft_id=info:doi/10.1080%2F10410230701314945 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - HECOER N1 - SubjectsTermNotLitGenreText - Metaphors; Strokes; Recovery; Reconstruction; Depression; Sense of self DO - http://dx.doi.org/10.1080/10410230701314945 ER - TY - JOUR T1 - Psychophysiological and subjective indices of emotion as a function of age and gender AN - 57205362; 200712530 AB - Old, middle-aged and young persons of both genders were presented with slides containing pictorial stimuli that varied in emotional content. Each picture was rated on three dimensions: (1) valence; (2) arousal; and (3) dominance, using a 25-point scale. Heart rate, skin conductance, and forehead and cheek EMG were recorded during each slide presentation. The old and middle-aged groups showed greatly attenuated psychophysiological responses, compared to the young group. However, the old and middle-aged subjects used more extreme ratings than the young subjects on both the valence and arousal dimensions. Females were more valence-sensitive than males, but males in general used more extreme ratings of arousal than females. These results suggest a tendency to report increased felt emotion but decreased physiological response to emotional stimuli across the life span. Adapted from the source document. JF - Cognition and Emotion AU - Burriss, Louisa AU - Powell, D A AU - White, Jeffrey AD - Neuroscience Laboratory (151A), Wm. Jennings Bryan Dorn VA Medical Center, 6439 Garners Ferry Road, Columbia, SC 29209-1639, USA E-mail: louisa.burriss@med.va.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 182 EP - 210 PB - Psychology Press/Taylor & Francis, Basingstoke UK VL - 21 IS - 1 SN - 0269-9931, 0269-9931 KW - Galvanic skin response KW - Age-Gender effects KW - Heart rate KW - Psychophysiological aspects KW - Electromyography KW - Emotional imagery KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57205362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cognition+and+Emotion&rft.atitle=Psychophysiological+and+subjective+indices+of+emotion+as+a+function+of+age+and+gender&rft.au=Burriss%2C+Louisa%3BPowell%2C+D+A%3BWhite%2C+Jeffrey&rft.aulast=Burriss&rft.aufirst=Louisa&rft.date=2007-01-01&rft.volume=21&rft.issue=1&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Cognition+and+Emotion&rft.issn=02699931&rft_id=info:doi/10.1080%2F02699930600562235 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-31 N1 - Last updated - 2016-09-27 N1 - CODEN - COEMEC N1 - SubjectsTermNotLitGenreText - Psychophysiological aspects; Emotional imagery; Age-Gender effects; Electromyography; Galvanic skin response; Heart rate DO - http://dx.doi.org/10.1080/02699930600562235 ER - TY - JOUR T1 - Meta-Analysis of Psychological Interventions for Chronic Low Back Pain AN - 57190228; 200711318 AB - The purpose of this meta-analysis of randomized controlled trials was to evaluate the efficacy of psychological interventions for adults with noncancerous chronic low back pain (CLBP). The authors updated and expanded upon prior meta-analyses by using broad definitions of CLBP and psychological intervention, a broad data search strategy, and state-of-the-art data analysis techniques. All relevant controlled clinical trials meeting the inclusion criteria were identified primarily through a computer-aided literature search. Two independent reviewers screened abstracts and articles for inclusion criteria and extracted relevant data. Cohen's d effect sizes were calculated by using a random effects model. Outcomes included pain intensity, emotional functioning, physical functioning (pain interference or pain-specific disability, health-related quality of life), participant ratings of global improvement, health care utilization, health care provider visits, pain medications, and employment/disability compensation status. A total of 205 effect sizes from 22 studies were pooled in 34 analyses. Positive effects of psychological interventions, contrasted with various control groups, were noted for pain intensity, pain-related interference, health-related quality of life, and depression. Cognitive-behavioral and self-regulatory treatments were specifically found to be efficacious. Multidisciplinary approaches that included a psychological component, when compared with active control conditions, were also noted to have positive short-term effects on pain interference and positive long-term effects on return to work. The results demonstrated positive effects of psychological interventions for CLBP. The rigor of the methods used, as well as the results that reflect mild to moderate heterogeneity and minimal publication bias, suggest confidence in the conclusions of this review. [Copyright 2007 The American Psychological Association.] JF - Health Psychology AU - Hoffman, Benson M AU - Papas, Rebecca K AU - Chatkoff, David K AU - Kerns, Robert D AD - Psychology Service (116B), VA Connecticut Healthcare System, West Haven Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 1 EP - 9 PB - American Psychological Association, Washington DC VL - 26 IS - 1 SN - 0278-6133, 0278-6133 KW - chronic low back pain, psychological intervention, meta-analysis KW - Chronic low back pain KW - Psychological intervention KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57190228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Psychology&rft.atitle=Meta-Analysis+of+Psychological+Interventions+for+Chronic+Low+Back+Pain&rft.au=Hoffman%2C+Benson+M%3BPapas%2C+Rebecca+K%3BChatkoff%2C+David+K%3BKerns%2C+Robert+D&rft.aulast=Hoffman&rft.aufirst=Benson&rft.date=2007-01-01&rft.volume=26&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2F0278-6133.26.1.1 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Chronic low back pain; Psychological intervention DO - http://dx.doi.org/10.1037/0278-6133.26.1.1 ER - TY - JOUR T1 - A Comparison of Televideo and Traditional In-Home Rehabilitation in Mobility Impaired Older Adult AN - 57190117; 200714169 AB - This paper reports on a randomized controlled trial to evaluate the effectiveness of using interactive video conferencing technology to diagnose problems, prescribe interventions, and implement solutions for six mobility and transfer tasks in comparison with traditional home visits. Thirty-two community-dwelling adults with new mobility devices were randomized into either traditional in-home (n = 16) or telerehab (n = 16) intervention group. Each group received weekly, one-hour therapy sessions for four consecutive weeks. There were no significant differences in the number of problems identified, recommendations made, or number of recommendations implemented for five of the six tasks. The only task for which there were significant differences, moving from room to room, is likely attributable to the nature of the protocol which did not accommodate an inherent limitation in the technology, rather than a fatal flaw in the technology itself. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Physical and Occupational Therapyin Geriatrics AU - Sanford, Jon A AU - Hoenig, Helen AU - Griffiths, Patricia C AU - Butterfield, Tina AU - Richardson, Peg AU - Hargraves, Katina AD - Center for Assistive Technology and Environmental Access, Georgia Tech, 1670 Clairmont Road, Decatur, GA 30033 E-mail: jon.sanford@med.va.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 1 EP - 18 PB - Haworth Press, Binghamton NY VL - 25 IS - 3 SN - 0270-3181, 0270-3181 KW - Assistive technology, home modification, in-home rehabilitation, occupational therapy, physical therapy, telerehabilitation KW - Rehabilitation KW - Physiotherapy KW - Occupational therapy KW - Home care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57190117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+and+Occupational+Therapyin+Geriatrics&rft.atitle=A+Comparison+of+Televideo+and+Traditional+In-Home+Rehabilitation+in+Mobility+Impaired+Older+Adult&rft.au=Sanford%2C+Jon+A%3BHoenig%2C+Helen%3BGriffiths%2C+Patricia+C%3BButterfield%2C+Tina%3BRichardson%2C+Peg%3BHargraves%2C+Katina&rft.aulast=Sanford&rft.aufirst=Jon&rft.date=2007-01-01&rft.volume=25&rft.issue=3&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Physical+and+Occupational+Therapyin+Geriatrics&rft.issn=02703181&rft_id=info:doi/10.1300%2FJ148v25n03_01 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-31 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Rehabilitation; Home care; Occupational therapy; Physiotherapy DO - http://dx.doi.org/10.1300/J148v25n03_01 ER - TY - JOUR T1 - Attributions and Reported Communication of a Diagnosis of Down Syndrome AN - 57109274; 200801916 AB - This study investigates attributions and reported communication in 97 neonatologists who responded to a vignette-based questionnaire depicting a woman with 1 of 3 prenatal screening histories for Down syndrome (DS) who had just given birth to a child with DS: not offered screening, refused screening, or received a false negative result on screening. Neonatologists reported blaming and attributing more control to women who refused prenatal screening for DS. Attributions of blame, but not control, were associated with reports of communicating more negative information on DS to parents. Neonatologists may make attributions about women on the basis of their screening histories, which appear to influence some but not all aspects of how they report communicating a diagnosis of DS. Adapted from the source document. JF - Health Communication AU - Elwy, A Rani AU - Michie, Susan AU - Marteau, Theresa M AD - Center for Health Quality, Outcomes and Economic Research, Edith Nourse Rogers Memorial Hospital, Veterans Health Administration, Department of Veterans Affairs, Boston University School of Public Health; Department of Health Policy and Management, Boston University School of Public Health, Boston, Massachusetts Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 115 EP - 121 PB - Taylor & Francis Group, Philadelphia PA VL - 22 IS - 2 SN - 1041-0236, 1041-0236 KW - Screening KW - Antenatal care KW - Neonatologists KW - Doctor-Patient communication KW - Down's syndrome KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57109274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Communication&rft.atitle=Attributions+and+Reported+Communication+of+a+Diagnosis+of+Down+Syndrome&rft.au=Elwy%2C+A+Rani%3BMichie%2C+Susan%3BMarteau%2C+Theresa+M&rft.aulast=Elwy&rft.aufirst=A&rft.date=2007-01-01&rft.volume=22&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Health+Communication&rft.issn=10410236&rft_id=info:doi/10.1080%2F10410230701453975 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - HECOER N1 - SubjectsTermNotLitGenreText - Neonatologists; Antenatal care; Screening; Down's syndrome; Doctor-Patient communication DO - http://dx.doi.org/10.1080/10410230701453975 ER - TY - JOUR T1 - Further Validation of the Alcohol Dependence Scale as an Index of Severity AN - 57094648; 200803057 AB - Objective: The Alcohol Dependence Scale (ADS) yields continuous scores purported to reflect the severity of the dependence syndrome. We evaluated the concurrent validity of the ADS as a general measure of severity and the screening accuracy of the total score and subscales to detect Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), physiological dependence. Method: Treatment-seeking, alcohol-dependent individuals entering the Combining Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) Study (N = 1,372, 69% men) completed the ADS, diagnostic interviews, and other measures before randomization. Analyses of variance tested differences between ADS quartiles on alcohol- related measures. Areas under the receiver operating characteristic (AUROC) curve assessed screening accuracy for DSM-IV physiological dependence (tolerance or withdrawal) or withdrawal alone. Results: ADS quartiles differed on age, other demographics, and prior treatment episodes. Linear correlation showed moderate to large magnitude associations with alcohol-related self-report measures and most indices of consumption. ADS quartiles differed significantly on proportion with DSM-IV physiological dependence, but AUROC curves indicated that the ADS had limited accuracy as a continuous measure to detect DSMIV physiological dependence (AUROC = .75 [95% confidence interval -- CI -- : .70-79] and .67 [95% CI: .60-.74] for men and women, respectively, p = .08) or withdrawal alone (AUROC = .77 [95% CI: .74-.80] and .74 [95% CI: .69-.79] for men and women, respectively, p = .30). Screening accuracy was comparably limited based on ADS subscales reflecting psychoperceptual or psychophysical withdrawal. Conclusions: The ADS reflected variation in symptom severity but did not adequately identi1' physiological dependence or withdrawal in treatment-seeking individuals with DSM-IV alcohol dependence. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Saxon, Andrew I AU - Kivlahan, Daniel R AU - Doyle, Suzanne AU - Donovan, Dennis M AD - Department of Psychiatry and Behavioral Sciences, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195 Andrew.saxon@med.va.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 149 EP - 156 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 68 IS - 1 SN - 1937-1888, 1937-1888 KW - Screening KW - Clinical assessment KW - Severity KW - Scales KW - Alcohol dependence KW - Accuracy KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57094648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Further+Validation+of+the+Alcohol+Dependence+Scale+as+an+Index+of+Severity&rft.au=Saxon%2C+Andrew+I%3BKivlahan%2C+Daniel+R%3BDoyle%2C+Suzanne%3BDonovan%2C+Dennis+M&rft.aulast=Saxon&rft.aufirst=Andrew&rft.date=2007-01-01&rft.volume=68&rft.issue=1&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alcohol dependence; Scales; Accuracy; Severity; Screening; Clinical assessment ER - TY - JOUR T1 - The interaction of age and hormone replacement therapy on colon adenoma risk AN - 20739423; 8566929 AB - Background: Several studies have identified a possible interaction between age and hormone replacement therapy on colon neoplasm risk. We re- evaluated this interaction and determined if this interaction may be explained by the longer duration of estrogen use in older, rather than younger, women. Methods: Included in the case-control study were 755 women (169 cases and 586 controls.) who were recruited from patients with no prior history of colorectal neoplasm and undergoing an elective colonoscopy examination. Results: There was a significant interaction between age and hormone replacement therapy use (P = 0.03) with current estrogen users who were over 56 years of age having a reduced odds of colon adenoma (OR, 0.40; 95% CI, 0.16-0.98) when compared to never users. Both older women who had used hormone replacement therapy for 3 or less years (OR, 0.07; 95% CI, 0.006-0.81) and those reporting greater than 10 years of use (OR, 0.27; 95% CI, 0.09-0.80) had a reduced adjusted odds for adenomas when compared to non- users. No apparent association with estrogen replacement therapy was found among younger women (<56 years). Conclusions: Duration of use is not likely to explain the stronger association of hormone replacement therapy use with colon neoplasm in older women. Additional work is needed to better characterize the underlying mechanisms associated with this interaction. JF - Cancer Detection and Prevention AU - Murff, Harvey J AU - Shrubsole, Martha J AU - Smalley, Walter E AU - Wu, Huiyun AU - Shyr, Yu AU - Ness, Reid M AU - Zheng, Wei AD - Division of General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, United States, Harvey.murff@va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 161 EP - 165 PB - International Society for Preventive Oncology, University of Massachusetts Medical Center 55 Lake Avenue North, Box 20 Worcester MA 01655 USA, [URL:http://www.cancerprev.org/ISPO/] VL - 31 IS - 2 SN - 0361-090X, 0361-090X KW - Risk Abstracts KW - Colon cancer KW - Polyps KW - Hormone replacement therapy KW - Chemoprevention KW - Historical account KW - Age KW - prevention KW - estrogen replacement therapy KW - hormone replacement therapy KW - Cancer KW - estrogens KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20739423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Detection+and+Prevention&rft.atitle=The+interaction+of+age+and+hormone+replacement+therapy+on+colon+adenoma+risk&rft.au=Murff%2C+Harvey+J%3BShrubsole%2C+Martha+J%3BSmalley%2C+Walter+E%3BWu%2C+Huiyun%3BShyr%2C+Yu%3BNess%2C+Reid+M%3BZheng%2C+Wei&rft.aulast=Murff&rft.aufirst=Harvey&rft.date=2007-01-01&rft.volume=31&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Cancer+Detection+and+Prevention&rft.issn=0361090X&rft_id=info:doi/10.1016%2Fj.cdp.2007.03.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Historical account; Age; estrogen replacement therapy; prevention; Cancer; hormone replacement therapy; estrogens DO - http://dx.doi.org/10.1016/j.cdp.2007.03.002 ER - TY - JOUR T1 - Pain and combat injuries in soldiers returning from Operations Enduring Freedom and Iraqi Freedom: Implications for research and practice AN - 20386103; 7918547 AB - Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) have resulted in a growing number of seriously injured soldiers who are evacuated to the United States for comprehensive medical care. Trauma-related pain is an almost universal problem among these war-injured soldiers, and several military and Department of Veterans Affairs initiatives have been implemented to enhance pain care across the continuum of medical services. This article describes several innovative approaches for improving the pain care provided to OEF and OIF military personnel during acute stabilization, transport, medical-surgical treatment, and rehabilitation and presents summary data characterizing the soldiers, pain management services provided, and associated outcomes. We also identify some of the pain assessment, classification, and treatment challenges emerging from work with this population and provide recommendations for future research and practice priorities. JF - Journal of Rehabilitation Research and Development AU - Clark, ME AU - Bair, MJ AU - Buckenmaier, CC III AU - Gironda, R J AU - Walker, R L AD - James A. Haley Veterans' Hospital, Chronic Pain Rehabilitation Program, 2CW, 13000 Bruce B. Downs Blvd, Tampa, FL 33612, USA, michael.clark8@.va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 179 EP - 194 VL - 44 IS - 2 SN - 0748-7711, 0748-7711 KW - Health & Safety Science Abstracts KW - USA KW - Injuries KW - War KW - pain KW - Military KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20386103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Pain+and+combat+injuries+in+soldiers+returning+from+Operations+Enduring+Freedom+and+Iraqi+Freedom%3A+Implications+for+research+and+practice&rft.au=Clark%2C+ME%3BBair%2C+MJ%3BBuckenmaier%2C+CC+III%3BGironda%2C+R+J%3BWalker%2C+R+L&rft.aulast=Clark&rft.aufirst=ME&rft.date=2007-01-01&rft.volume=44&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2006.05.0057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Injuries; War; pain; Military; Occupational health; USA DO - http://dx.doi.org/10.1682/JRRD.2006.05.0057 ER - TY - JOUR T1 - Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors AN - 20307500; 7519000 AB - Extensive work in recent years has suggested that a number of endogenous molecules, their-derivatives or degradation products may be potent activators of the innate immune system capable of inducing pro-inflammatory cytokine production by the monocyte-macrophage system and the activation and maturation of dendritic cells. The cytokine-like effects of these endogenous molecules are mediated via Toll-like receptor (TLR) signal transduction pathways in a manner similar to pathogen-associated molecular patterns (PAMPs). However, recent evidence suggests that the reported cytokine effects of some of these putative endogenous ligands are in fact due to contaminating PAMPs. The reasons for the failure to recognize PAMP contaminants being responsible for the putative TLR ligands of these endogenous molecules include: (i) failure to use highly purified preparations free of PAMP contamination; (ii) failure to recognize the heat sensitivity of lipopoly-saccharide (LPS); and (iii) failure to consider contaminant(s) other than LPS. Strategies are proposed to avoid future designation of PAMP contamination as putative endogenous ligands of TLRs. JF - Journal of Endotoxin Research AU - Tsan, M-F AU - Gao, B AD - Mid-Atlantic Regional Office (10R), Office of Research Oversight, Department of Veterans Affairs, 50 Irving Street, NW, Washington, DC 20422, USA, min-fu.tsan2@med.va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 6 EP - 14 VL - 13 IS - 1 SN - 0968-0519, 0968-0519 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Endotoxins KW - Macrophages KW - Contamination KW - Immune system KW - Cell activation KW - Dendritic cells KW - Heat KW - Cytokines KW - Lipopolysaccharides KW - Monocytes KW - Contaminants KW - Toll-like receptors KW - Degradation products KW - Signal transduction KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20307500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Endotoxin+Research&rft.atitle=Pathogen-associated+molecular+pattern+contamination+as+putative+endogenous+ligands+of+Toll-like+receptors&rft.au=Tsan%2C+M-F%3BGao%2C+B&rft.aulast=Tsan&rft.aufirst=M-F&rft.date=2007-01-01&rft.volume=13&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Journal+of+Endotoxin+Research&rft.issn=09680519&rft_id=info:doi/10.1177%2F0968051907078604 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Endotoxins; Contamination; Immune system; Cell activation; Dendritic cells; Heat; Lipopolysaccharides; Cytokines; Monocytes; Contaminants; Toll-like receptors; Signal transduction; Degradation products DO - http://dx.doi.org/10.1177/0968051907078604 ER - TY - JOUR T1 - Adverse events among high-risk participants in a home-based walking study: a descriptive study AN - 20052230; 9035839 AB - Background For high-risk individuals and their healthcare providers, finding the right balance between promoting physical activity and minimizing the risk of adverse events can be difficult. More information on the prevalence and influence of adverse events is needed to improve providers' ability to prescribe effective and safe exercise programs for their patients. Methods This study describes the type and severity of adverse events reported by participants with cardiovascular disease or at-risk for cardiovascular disease that occurred during an unsupervised, home-based walking study. This multi-site, randomized controlled trial tested the feasibility of a diet and lifestyle activity intervention over 1.5 years. At month 13, 274 eligible participants (male veterans) were recruited who were ambulatory, BMI > 28, and reporting one or more cardiovascular disease risk factors. All participants attended five, face-to-face dietitian-delivered counseling sessions during the six-month intervention. Participants were randomized to three study arms: 1) time-based walking goals, 2) simple pedometer-based walking goals, and 3) enhanced pedometer-based walking goals with Internet-mediated feedback. Two physicians verified adverse event symptom coding. Results Enrolled participants had an average of five medical comorbidities. During 1110 person months of observation, 87 of 274 participants reported 121 adverse events. One serious study-related adverse event (atrial fibrillation) was reported; the individual resumed study participation within three days. Non-serious, study related adverse events made up 12% of all symptoms - predominantly minor musculoskeletal events. Serious, non-study related adverse events represented 32% of all symptoms while non-serious, non-study related adverse events made up 56% of symptoms. Cardiovascular disease events represented over half of the non-study related adverse event symptoms followed by musculoskeletal complaints. Adverse events caused 50 temporary suspensions averaging 26 days in duration before physician medical clearance was obtained to resume walking. Conclusion Men at high risk for adverse cardiovascular events can safely be advised to start a progressive walking program. Results suggest that minor to serious medical problems unrelated to exercise are a major barrier to walking adherence. Helping individuals with chronic illness return to physical activity quickly but safely after an adverse event is an important component of any physical activity intervention targeting this population. JF - International Journal of Behavioral Nutrition and Physical Activity AU - Goodrich, David E AU - Larkin, Angela R AU - Lowery, Julie C AU - Holleman, Robert G AU - Richardson, Caroline R AD - HSR&D Center for Excellence, VA Health Care Medical Center, P.O. Box 130170, Ann Arbor, MI 48113-0170, USA, david.goodrich2@va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 20 PB - BioMed Central Ltd., Middlesex House VL - 4 SN - 1479-5868, 1479-5868 KW - Physical Education Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20052230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.atitle=Adverse+events+among+high-risk+participants+in+a+home-based+walking+study%3A+a+descriptive+study&rft.au=Goodrich%2C+David+E%3BLarkin%2C+Angela+R%3BLowery%2C+Julie+C%3BHolleman%2C+Robert+G%3BRichardson%2C+Caroline+R&rft.aulast=Goodrich&rft.aufirst=David&rft.date=2007-01-01&rft.volume=4&rft.issue=&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.issn=14795868&rft_id=info:doi/10.1186%2F1479-5868-4-20 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1186/1479-5868-4-20 ER - TY - JOUR T1 - Transgenerational transmission of cortisol and PTSD risk AN - 19612562; 8581785 AB - Parental posttraumatic stress disorder (PTSD) appears to be a relevant risk factor for the development of PTSD, as evidenced by a greater prevalence of PTSD, but not trauma exposure, in adult offspring of Holocaust survivors with PTSD, compared to children of Holocaust-exposed parents without PTSD. This paper summarizes recent neuroendocrine studies in offspring of parents with PTSD. Offspring of trauma survivors with PTSD show significantly lower 24-h mean urinary cortisol excretion and salivary cortisol levels as well as enhanced plasma cortisol suppression in response to low dose dexamethasone administration than offspring of survivors without PTSD. In all cases, neuroendocrine measures were negatively correlated with severity of parental PTSD symptoms, even after controlling for PTSD and even other symptoms in offspring. Though the majority of our work has focused on adult offspring of Holocaust survivors, recent observations in infants born to mothers who were pregnant on 9/11 demonstrate that low cortisol in relation to parental PTSD appears to be present early in the course of development and may be influenced by in utero factors such as glucocorticoid programming. Since low cortisol levels are particularly associated with the presence of maternal PTSD the findings suggest the involvement of epigenetic mechanisms. JF - Progress in Brain Research AU - Yehuda, Rachel AU - Bierer, Linda M AD - The Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs, James J. Peters VAMC, 116-A, OOMH-PTSD, 130 West Kingsbridge Road, Bronx, NY 10468, USA, Rachel.yehuda@va.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 121 EP - 135 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 167 SN - 0079-6123, 0079-6123 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - posttraumatic stress disorder KW - glucocorticoid programming KW - epigenetics KW - cortisol KW - intergenerational effects KW - risk factors KW - Dexamethasone KW - Hydrocortisone KW - Children KW - Glucocorticoids KW - Post-traumatic stress disorder KW - Pregnancy KW - Trauma KW - Neurotransmission KW - Risk factors KW - Reviews KW - Excretion KW - Progeny KW - Infants KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle KW - N3 11009:Neuroendocrinology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19612562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+Brain+Research&rft.atitle=Transgenerational+transmission+of+cortisol+and+PTSD+risk&rft.au=Yehuda%2C+Rachel%3BBierer%2C+Linda+M&rft.aulast=Yehuda&rft.aufirst=Rachel&rft.date=2007-01-01&rft.volume=167&rft.issue=&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Progress+in+Brain+Research&rft.issn=00796123&rft_id=info:doi/10.1016%2FS0079-6123%2807%2967009-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Dexamethasone; Hydrocortisone; Children; Post-traumatic stress disorder; Glucocorticoids; Trauma; Pregnancy; Neurotransmission; epigenetics; Reviews; Risk factors; Progeny; Excretion; Infants DO - http://dx.doi.org/10.1016/S0079-6123(07)67009-5 ER - TY - JOUR T1 - Methodological challenges confronting researchers of wheeled mobility aids and other assistive technologies AN - 1347818728; 201306390 AB - Purpose. To identify gaps in assistive technology (AT) research and solutions, with a focus on wheeled mobility. Methods. Literature review. Results. AT researchers have identified a need to move beyond determining whether a device works well in the laboratory or is perceived favorably by users. The vital next step in AT research is to determine the effects of AT when used for day-to-day activities by typical consumers. Four challenges affect AT research on everyday mobility: 1. the heterogeneity of the population using AT, the environments in which AT is used, and the devices themselves; 2. the dependency of empirical research on objective data for valid causal inference; 3. the need for detailed information to capture the interaction between the person, the device, and the environment in which it is used; and 4. the extent to which success or failure of AT is dependent on the personal perspectives of the individual using the device. These challenges are being addressed by AT researchers through use of new measures, novel data collection methods, and by linking quantitative with qualitative data. Conclusions: AT researchers are adapting traditional research designs and analytic methods to examine that effects of AT on everyday life. Adapted from the source document. JF - Disability and Rehabilitation: Assistive Technology AU - Hoenig, Helen AU - Giacobbi, Peter AU - Levy, Charles E AD - Department of Medicine/Geriatrics, Duke University Medical Center, Physical Medicine & Rehabilitation Service, Durham Veterans Affairs Medical Center, Durham, NC, USA helen.hoenig@va.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 159 EP - 168 PB - Informa HealthCare, Abingdon UK VL - 2 IS - 3 SN - 1748-3107, 1748-3107 KW - Self-help devices, wheelchair, rehabilitation, durable medical equipment, activities of daily living, architectural accessibility, walking, housing, physical therapy, occupational therapy, residential mobility, methods, weights and measures, data collection KW - Mobility KW - Laboratories KW - Everyday life KW - Consumers KW - Heterogeneity KW - Technical aids KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1347818728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Disability+and+Rehabilitation%3A+Assistive+Technology&rft.atitle=Methodological+challenges+confronting+researchers+of+wheeled+mobility+aids+and+other+assistive+technologies&rft.au=Hoenig%2C+Helen%3BGiacobbi%2C+Peter%3BLevy%2C+Charles+E&rft.aulast=Hoenig&rft.aufirst=Helen&rft.date=2007-01-01&rft.volume=2&rft.issue=3&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Disability+and+Rehabilitation%3A+Assistive+Technology&rft.issn=17483107&rft_id=info:doi/10.1080%2F17483100701374405 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Technical aids; Mobility; Laboratories; Heterogeneity; Consumers; Everyday life DO - http://dx.doi.org/10.1080/17483100701374405 ER - TY - JOUR T1 - Ertapenem versus cefotetan prophylaxis in elective colorectal surgery. AN - 68264944; 17182989 AB - Ertapenem, a long-acting carbapenem, may be an alternative to the recommended prophylactic antibiotic cefotetan. In this randomized, double-blind trial, we assessed the efficacy and safety of antibiotic prophylaxis with ertapenem, as compared with cefotetan, in patients undergoing elective colorectal surgery. A successful outcome was defined as the absence of surgical-site infection, anastomotic leakage, or antibiotic use 4 weeks postoperatively. All adverse events were collected until 14 days after the administration of antibiotic prophylaxis. Of the 1002 patients randomly assigned to study groups, 901 (451 in the ertapenem group and 450 in the cefotetan group) qualified for the modified intention-to-treat analysis, and 672 (338 in the ertapenem group and 334 in the cefotetan group) were included in the per-protocol analysis. After adjustment for strata, in the modified intention-to-treat analysis, the rate of overall prophylactic failure was 40.2% in the ertapenem group and 50.9% in the cefotetan group (absolute difference, -10.7%; 95% confidence interval [CI], -17.1 to -4.2); in the per-protocol analysis, the failure rate was 28.0% in the ertapenem group and 42.8% in the cefotetan group (absolute difference, -14.8%; 95% CI, -21.9 to -7.5). Both analyses fulfilled statistical criteria for the superiority of ertapenem. In the modified intention-to-treat analysis, the most common reason for failure of prophylaxis in both groups was surgical-site infection: 17.1% in the ertapenem group and 26.2% in the cefotetan group (absolute difference, -9.1; 95% CI, -14.4 to -3.7). In the treated population, the overall incidence of Clostridium difficile infection was 1.7% in the ertapenem group and 0.6% in the cefotetan group (P=0.22). Ertapenem is more effective than cefotetan in the prevention of surgical-site infection in patients undergoing elective colorectal surgery but may be associated with an increase in C. difficile infection. (ClinicalTrials.gov number, NCT00090272 [ClinicalTrials.gov].). Copyright 2006 Massachusetts Medical Society. JF - The New England journal of medicine AU - Itani, Kamal M F AU - Wilson, Samuel E AU - Awad, Samir S AU - Jensen, Erin H AU - Finn, Tyler S AU - Abramson, Murray A AD - Veterans Affairs Boston Healthcare System and Boston University Medical School, Boston, MA 02132, USA. kitani@med.va.gov Y1 - 2006/12/21/ PY - 2006 DA - 2006 Dec 21 SP - 2640 EP - 2651 VL - 355 IS - 25 KW - Anti-Bacterial Agents KW - 0 KW - beta-Lactams KW - Cefotetan KW - 48SPP0PA9Q KW - ertapenem KW - G32F6EID2H KW - Abridged Index Medicus KW - Index Medicus KW - Treatment Failure KW - Analysis of Variance KW - Elective Surgical Procedures KW - Double-Blind Method KW - Infusions, Intravenous KW - Humans KW - Aged KW - Prospective Studies KW - Aged, 80 and over KW - Logistic Models KW - Risk Factors KW - Adult KW - Middle Aged KW - Clostridium difficile KW - Clostridium Infections KW - Male KW - Female KW - Anti-Bacterial Agents -- therapeutic use KW - beta-Lactams -- adverse effects KW - beta-Lactams -- administration & dosage KW - Anti-Bacterial Agents -- adverse effects KW - Surgical Wound Infection -- prevention & control KW - Cefotetan -- adverse effects KW - Cefotetan -- administration & dosage KW - Antibiotic Prophylaxis KW - beta-Lactams -- therapeutic use KW - Colorectal Surgery KW - Cefotetan -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68264944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Ertapenem+versus+cefotetan+prophylaxis+in+elective+colorectal+surgery.&rft.au=Itani%2C+Kamal+M+F%3BWilson%2C+Samuel+E%3BAwad%2C+Samir+S%3BJensen%2C+Erin+H%3BFinn%2C+Tyler+S%3BAbramson%2C+Murray+A&rft.aulast=Itani&rft.aufirst=Kamal+M&rft.date=2006-12-21&rft.volume=355&rft.issue=25&rft.spage=2640&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-28 N1 - Date created - 2006-12-21 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00090272; ClinicalTrials.gov N1 - SuppNotes - Comment In: N Engl J Med. 2006 Dec 21;355(25):2693-5 [17182996] N Engl J Med. 2007 Apr 19;356(16):1684; author reply 1685 [17442916] N Engl J Med. 2007 Apr 19;356(16):1685; author reply 1685 [17447286] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of proteasome inhibition on toxicity and CYP3A23 induction in cultured rat hepatocytes: comparison with arsenite. AN - 68244040; 17083955 AB - Previous work in our laboratory has shown that acute exposure of primary rat hepatocyte cultures to non-toxic concentrations of arsenite causes major decreases in the DEX-mediated induction of CYP3A23 protein, with minor decreases in CYP3A23 mRNA. To elucidate the mechanism for these effects of arsenite, the effects of arsenite and proteasome inhibition, separately and in combination, on induction of CYP3A23 protein were compared. The proteasome inhibitor, MG132, inhibited proteasome activity, but also decreased CYP3A23 mRNA and protein. Lactacystin, another proteasome inhibitor, decreased CYP3A23 protein without affecting CYP3A23 mRNA at a concentration that effectively inhibited proteasome activity. This result, suggesting that the action of lactacystin is similar to arsenite and was post-transcriptional, was confirmed by the finding that lactacystin decreased association of DEX-induced CYP3A23 mRNA with polyribosomes. Both MG132 and lactacystin inhibited total protein synthesis, but did not affect MTT reduction. Arsenite had no effect on ubiquitination of proteins, nor did arsenite significantly affect proteasomal activity. These results suggest that arsenite and lactacystin act by similar mechanisms to inhibit translation of CYP3A23. JF - Toxicology and applied pharmacology AU - Noreault-Conti, Trisha L AU - Jacobs, Judith M AU - Trask, Heidi W AU - Wrighton, Steven A AU - Sinclair, Jacqueline F AU - Nichols, Ralph C AD - Veterans Administration Medical Center, White River Junction, VT 05009, USA. Y1 - 2006/12/15/ PY - 2006 DA - 2006 Dec 15 SP - 245 EP - 251 VL - 217 IS - 3 SN - 0041-008X, 0041-008X KW - Arsenites KW - 0 KW - Cysteine Proteinase Inhibitors KW - Leupeptins KW - Proteasome Inhibitors KW - RNA, Messenger KW - lactacystin KW - 133343-34-7 KW - Dexamethasone KW - 7S5I7G3JQL KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP3A23 protein, rat KW - Cytochrome P-450 CYP3A KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - arsenite KW - N5509X556J KW - benzyloxycarbonylleucyl-leucyl-leucine aldehyde KW - RF1P63GW3K KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Animals KW - Drug Interactions KW - Acetylcysteine -- analogs & derivatives KW - Leupeptins -- toxicity KW - Dexamethasone -- pharmacology KW - Acetylcysteine -- toxicity KW - Proteasome Endopeptidase Complex -- drug effects KW - Rats KW - Rats, Inbred F344 KW - RNA, Messenger -- metabolism KW - Cells, Cultured KW - Cysteine Proteinase Inhibitors -- toxicity KW - Male KW - Hepatocytes -- drug effects KW - Arsenites -- toxicity KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Hepatocytes -- enzymology KW - Aryl Hydrocarbon Hydroxylases -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68244040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Effect+of+proteasome+inhibition+on+toxicity+and+CYP3A23+induction+in+cultured+rat+hepatocytes%3A+comparison+with+arsenite.&rft.au=Noreault-Conti%2C+Trisha+L%3BJacobs%2C+Judith+M%3BTrask%2C+Heidi+W%3BWrighton%2C+Steven+A%3BSinclair%2C+Jacqueline+F%3BNichols%2C+Ralph+C&rft.aulast=Noreault-Conti&rft.aufirst=Trisha&rft.date=2006-12-15&rft.volume=217&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-02 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Medication status affects the relationship of symptoms to prepulse inhibition of acoustic startle in schizophrenia. AN - 68168927; 17070928 AB - Inhibition of the acoustic startle response by a smaller preliminary nonstartling stimulus is termed prepulse inhibition (PPI). Schizophrenia patients have impairments in PPI that may not fully normalize even when they are clinically stable on medication, particularly typical antipsychotics. There is evidence that more severe symptoms are associated with more severe PPI abnormalities, but the effect of antipsychotics on this relationship is not clear. Seventy-three male schizophrenia patients underwent acoustic startle and PPI testing. Symptom ratings were performed using the Brief Psychiatric Rating Scale (BPRS) and its subscales. Fifty-two subjects were treated with antipsychotic medication at time of testing; 21 were unmedicated. For all subjects, PPI was negatively correlated with the BPRS psychological discomfort subscale but not with BPRS total symptoms, BPRS positive symptoms or BPRS negative symptoms. For medicated subjects analyzed separately, there were no correlations with BPRS total scores or any subscales. For the unmedicated subjects analyzed separately, there were significant correlations of lower PPI with greater severity of BPRS total symptoms, positive symptoms and the psychological discomfort subscale. These data indicate that more severe symptoms are associated with lower PPI, but that medication status is an important factor in the relationship between symptom severity and sensorimotor gating. JF - Psychiatry research AU - Duncan, Erica J AU - Bollini, Annie M AU - Lewison, Barbara AU - Keyes, Megan AU - Jovanovic, Tanja AU - Gaytan, Osvaldo AU - Egan, Glenn AU - Szilagyi, Sandor AU - Schwartz, Marion AU - Parwani, Arti AU - Chakravorty, Subhajit AU - Rotrosen, John AD - Atlanta Veterans Administration Medical Center, Decatur, GA, USA. erica.duncan@va.gov Y1 - 2006/12/07/ PY - 2006 DA - 2006 Dec 07 SP - 137 EP - 145 VL - 145 IS - 2-3 SN - 0165-1781, 0165-1781 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Severity of Illness Index KW - Demography KW - Humans KW - Electromyography KW - Middle Aged KW - Brief Psychiatric Rating Scale KW - Time Factors KW - Male KW - Reflex, Startle -- drug effects KW - Affect -- drug effects KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenia -- diagnosis KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Auditory Perception -- drug effects KW - Inhibition (Psychology) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68168927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Medication+status+affects+the+relationship+of+symptoms+to+prepulse+inhibition+of+acoustic+startle+in+schizophrenia.&rft.au=Duncan%2C+Erica+J%3BBollini%2C+Annie+M%3BLewison%2C+Barbara%3BKeyes%2C+Megan%3BJovanovic%2C+Tanja%3BGaytan%2C+Osvaldo%3BEgan%2C+Glenn%3BSzilagyi%2C+Sandor%3BSchwartz%2C+Marion%3BParwani%2C+Arti%3BChakravorty%2C+Subhajit%3BRotrosen%2C+John&rft.aulast=Duncan&rft.aufirst=Erica&rft.date=2006-12-07&rft.volume=145&rft.issue=2-3&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-01 N1 - Date created - 2006-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical trial to compare tinnitus masking and tinnitus retraining therapy. AN - 85399176; pmid-17114146 AB - Both tinnitus masking (TM) and tinnitus retraining therapy (TRT) can be effective therapies for amelioration of tinnitus. TM may be more effective for patients in the short term, but with continued treatment TRT may produce the greatest effects.Although TM and TRT have been used for many years, research has not documented definitively the efficacy of these methods. The present study was a controlled clinical trial to prospectively evaluate the clinical efficacy of these two methods for US military veterans with severe tinnitus.Over 800 veterans were screened to ensure that enrolled patients had tinnitus of sufficient severity to justify 18 months of individualized treatment. Qualifying patients (n=123) were placed quasi-randomly (alternating placement) into treatment with either TM or TRT. Treatment was administered at 0, 3, 6, 12, and 18 months. Outcomes of treatment were evaluated primarily using three self-administered tinnitus questionnaires (Tinnitus Handicap Inventory, Tinnitus Handicap Questionnaire, Tinnitus Severity Index).Findings are presented from the three written questionnaires with respect to three categories of patients: describing tinnitus as a 'moderate,' 'big,' and 'very big' problem at baseline. Based on effect sizes, both groups showed considerable improvement overall. In general, TM effects remained fairly constant over time while TRT effects improved incrementally. For the patients with a 'moderate' and 'big' problem, TM provided the greatest benefit at 3 and 6 months; benefit to these TRT patients was slightly greater at 12 months, and much greater at 18 months. For patients with a 'very big' problem, TM provided the greatest benefit at 3 months. For these latter patients, results were about the same between groups at 6 months, and improvement for TRT was much greater at 12 months, with further gains at 18 months. JF - Acta oto-laryngologica. Supplementum AU - Henry, J A AU - Schechter, M A AU - Zaugg, T L AU - Griest, S AU - Jastreboff, P J AU - Vernon, J A AU - Kaelin, C AU - Meikle, M B AU - Lyons, K S AU - Stewart, B J AD - VA RR&D National Center for Rehabilitative Auditory Research, VA Medical Center (VAMC), Portland, OR, USA. james.henry@med.va.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 64 EP - 69 IS - 556 SN - 0365-5237, 0365-5237 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation: instrumentation KW - Acoustic Stimulation: methods KW - Counseling KW - Disability Evaluation KW - Female KW - Humans KW - Male KW - Middle Aged KW - Military Personnel KW - *Perceptual Masking: physiology KW - Prospective Studies KW - Questionnaires KW - Severity of Illness Index KW - *Tinnitus: diagnosis KW - *Tinnitus: rehabilitation KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85399176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+oto-laryngologica.+Supplementum&rft.atitle=Clinical+trial+to+compare+tinnitus+masking+and+tinnitus+retraining+therapy.&rft.au=Henry%2C+J+A%3BSchechter%2C+M+A%3BZaugg%2C+T+L%3BGriest%2C+S%3BJastreboff%2C+P+J%3BVernon%2C+J+A%3BKaelin%2C+C%3BMeikle%2C+M+B%3BLyons%2C+K+S%3BStewart%2C+B+J&rft.aulast=Henry&rft.aufirst=J&rft.date=2006-12-01&rft.volume=&rft.issue=556&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Acta+oto-laryngologica.+Supplementum&rft.issn=03655237&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Examining the correlates of psychological aggression among a community sample of couples. AN - 68257312; 17176192 AB - In this study, the authors examined the correlates of psychological aggression victimization and perpetration among a community sample of 145 heterosexual couples. For both women and men, psychological aggression victimization was associated with greater psychological distress, anxiety, and physical health symptoms beyond the effects of physical aggression. Psychological aggression victimization was also uniquely associated with higher levels of depression for women. Trait anger and poor relationship adjustment were the strongest correlates of psychological aggression perpetration across genders. Childhood father-to-child and father-to-mother aggressions were associated with psychological aggression perpetration for men only, suggesting possible distinct etiologies across genders. These data highlight the importance of the further development of models for psychological aggression in both women and men. (c) 2006 APA, all rights reserved. JF - Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) AU - Taft, Casey T AU - O'Farrell, Timothy J AU - Torres, Sandra E AU - Panuzio, Jillian AU - Monson, Candice M AU - Murphy, Marie AU - Murphy, Christopher M AD - Behavioral Science Division, National Center for Posttraumatic Stress Disorder, VA Boston Healthcare System, Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA. casey.taft@va.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 581 EP - 588 VL - 20 IS - 4 SN - 0893-3200, 0893-3200 KW - Index Medicus KW - Alcoholism -- rehabilitation KW - Child Abuse -- psychology KW - Child Abuse -- statistics & numerical data KW - Humans KW - Personality Inventory KW - Child KW - Alcoholism -- psychology KW - Anger KW - Cross-Sectional Studies KW - Alcoholism -- epidemiology KW - Risk Factors KW - Adult KW - Middle Aged KW - Statistics as Topic KW - Female KW - Male KW - Depressive Disorder -- epidemiology KW - Crime Victims -- statistics & numerical data KW - Somatoform Disorders -- epidemiology KW - Depressive Disorder -- psychology KW - Anxiety Disorders -- psychology KW - Aggression -- psychology KW - Crime Victims -- psychology KW - Somatoform Disorders -- psychology KW - Spouse Abuse -- statistics & numerical data KW - Anxiety Disorders -- epidemiology KW - Spouse Abuse -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68257312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+family+psychology+%3A+JFP+%3A+journal+of+the+Division+of+Family+Psychology+of+the+American+Psychological+Association+%28Division+43%29&rft.atitle=Examining+the+correlates+of+psychological+aggression+among+a+community+sample+of+couples.&rft.au=Taft%2C+Casey+T%3BO%27Farrell%2C+Timothy+J%3BTorres%2C+Sandra+E%3BPanuzio%2C+Jillian%3BMonson%2C+Candice+M%3BMurphy%2C+Marie%3BMurphy%2C+Christopher+M&rft.aulast=Taft&rft.aufirst=Casey&rft.date=2006-12-01&rft.volume=20&rft.issue=4&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Journal+of+family+psychology+%3A+JFP+%3A+journal+of+the+Division+of+Family+Psychology+of+the+American+Psychological+Association+%28Division+43%29&rft.issn=08933200&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-06 N1 - Date created - 2006-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exacerbation of psychiatric symptoms during substance use disorder treatment. AN - 68247301; 17158491 AB - This study examined psychiatric symptom exacerbation (or deterioration) among patients treated for substance use disorders. The study examined several questions. What is the prevalence of deterioration during residential treatment? Compared with patients who show improvement in psychiatric symptoms, do those with deterioration of symptoms report poorer functioning during treatment and one year after treatment entry? Do patients who experience deterioration of symptoms one year after treatment entry enter treatment with more problems and poorer coping skills? Is the prevalence of deterioration associated with treatment orientation, and do patients whose psychiatric symptoms deteriorate view the treatment environment more negatively than patients whose symptoms improve? A total of 3,322 male patients were recruited at 15 residential substance abuse treatment programs in the Department of Veterans Affairs health care system between 1992 and 1995. On the basis of changes in psychiatric symptoms during treatment, these patients were categorized as having either deteriorated or improved psychiatric symptoms. Patients whose symptoms deteriorated were compared with a matched group of patients with improved symptoms. A total of 426 patients (13 percent) reported a worsening of psychiatric symptoms during treatment. Compared with patients in the improved group (N=426), patients in the deteriorated group reported more psychiatric problems and substance use one year after treatment. Patients in the deteriorated group were more likely to have a psychotic diagnosis, lower self-efficacy, and more reliance on coping by expression of emotions and to view the treatment experience more negatively. Thirteen percent of the patients experienced an exacerbation of psychiatric symptoms during residential substance use disorder treatment. Improved monitoring procedures, such as regular assessments for changes in psychiatric symptoms, are needed to routinely obtain information about declines in psychiatric conditions during treatment. JF - Psychiatric services (Washington, D.C.) AU - Ilgen, Mark A AU - Moos, Rudolf H AD - Department of Veterans Affairs Palo Alto Health Care System, CA 94025, USA. mark.ilgen@med.va.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1758 EP - 1764 VL - 57 IS - 12 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - United States KW - Diagnosis, Dual (Psychiatry) -- methods KW - Analysis of Variance KW - Attitude to Health KW - Adaptation, Psychological -- physiology KW - Humans KW - Prognosis KW - Expressed Emotion -- physiology KW - Episode of Care KW - Psychotic Disorders -- epidemiology KW - Comorbidity KW - Psychotic Disorders -- psychology KW - Self Concept KW - United States Department of Veterans Affairs KW - Adult KW - Treatment Outcome KW - Follow-Up Studies KW - Male KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68247301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Exacerbation+of+psychiatric+symptoms+during+substance+use+disorder+treatment.&rft.au=Ilgen%2C+Mark+A%3BMoos%2C+Rudolf+H&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2006-12-01&rft.volume=57&rft.issue=12&rft.spage=1758&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-20 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Short and long-term mortality with nesiritide. AN - 68229750; 17161057 AB - Nesiritide (recombinant human B-type natriuretic peptide) has been shown to provide symptomatic and hemodynamic improvement in acute decompensated heart failure. A previous meta-analysis of 3 randomized controlled trials has suggested an increased short-term risk of death with nesiritide use. We performed a meta-analysis of 7 available randomized controlled trials to evaluate the short- and long-term risk of death with nesiritide use for acute decompensated heart failure. Seven large randomized controlled nonmortality trials on nesiritide with available data on 30-day mortality were included. Data on 180-day mortality were available only in 4 trials. Mortality data in nesiritide and control arms were extracted from the selected trials and the nesiritide database (Scios Inc, Fremont, CA). The pooled estimate of the relative risks (RRs) for unadjusted 30- and 180-day mortality revealed no significant differences between the nesiritide arm (RR 1.243, 95% CI 0.798-1.935) and control arm (RR, 0.002, 95% CI 0.798-1.259), respectively). Unlike a previous analysis, our meta-analysis indicates that nesiritide is not associated with a higher 30- or 180-day mortality. Further analysis of mortality adjusted for confounding variables such as nesiritide dose, duration of infusion, concurrent use of inotropes, heart failure stage, and arrhythmias may reveal subgroups in jeopardy. Large-scale randomized controlled trials powered to evaluate mortality are required to conclusively address these findings. JF - American heart journal AU - Arora, Rohit R AU - Venkatesh, Prasanna Kumar AU - Molnar, Janos AD - The Department of Medicine, The Chicago Medical School, Chicago, IL 60064, USA. rohit.arora@va.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1084 EP - 1090 VL - 152 IS - 6 KW - Natriuretic Agents KW - 0 KW - Natriuretic Peptide, Brain KW - 114471-18-0 KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Risk KW - Randomized Controlled Trials as Topic KW - Humans KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - Natriuretic Peptide, Brain -- therapeutic use KW - Natriuretic Agents -- adverse effects KW - Heart Failure -- mortality KW - Heart Failure -- drug therapy KW - Natriuretic Peptide, Brain -- adverse effects KW - Natriuretic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68229750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Short+and+long-term+mortality+with+nesiritide.&rft.au=Arora%2C+Rohit+R%3BVenkatesh%2C+Prasanna+Kumar%3BMolnar%2C+Janos&rft.aulast=Arora&rft.aufirst=Rohit&rft.date=2006-12-01&rft.volume=152&rft.issue=6&rft.spage=1084&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=1097-6744&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-08 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am Heart J. 2007 Jun;153(6):e43; author reply e45 [17540185] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Linking opioid-dependent hospital patients to drug treatment: Health care use and costs 6 months after randomization. AN - 68227248; 17156179 AB - To conduct an economic evaluation of the first 6 months' trial of treatment vouchers and case management for opioid-dependent hospital patients. Randomized clinical trial and evaluation of administrative data. Emergency department, wound clinic, in-patient units and methadone clinic in a large urban public hospital. The study randomized 126 opioid-dependent drug users seeking medical care. Participants were randomized among four groups. These received vouchers for 6 months of methadone treatment, 6 months of case management, both these interventions, or usual care. During the first 6 months of this study, 90% of those randomized to vouchers alone enrolled in methadone maintenance, significantly more than the 44% enrollment in those randomized to case management without vouchers (P < 0.001). The direct costs of substance abuse treatment, including case management, was 4040 dollars for those who received vouchers, 4177 dollars for those assigned to case management and 5277 dollars for those who received the combination of both interventions. After 3 months, the vouchers alone group used less heroin than the case management alone group. The difference was not significant at 6 months. There were no significant differences in other health care costs in the 6 months following randomization. Vouchers were slightly more effective but no more costly than case management during the initial 6 months of the study. Vouchers were as effective and less costly than the combination of case management and vouchers. The finding that vouchers dominate is tempered by the possibility that case management may lower medical care costs. JF - Addiction (Abingdon, England) AU - Barnett, Paul G AU - Masson, Carmen L AU - Sorensen, James L AU - Wong, Wynnie AU - Hall, Sharon AD - Department of Psychiatry, University of California, San Francisco, CA, USA. paul.barnett@va.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1797 EP - 1804 VL - 101 IS - 12 SN - 0965-2140, 0965-2140 KW - Narcotics KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Humans KW - Emergency Medical Services -- utilization KW - Emergency Medical Services -- economics KW - Hospitalization -- economics KW - Adult KW - Aged KW - Middle Aged KW - Hospitalization -- statistics & numerical data KW - Adolescent KW - Male KW - Female KW - Case Management -- economics KW - Health Care Costs -- statistics & numerical data KW - Methadone -- therapeutic use KW - Narcotics -- economics KW - Methadone -- economics KW - Narcotics -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation KW - Opioid-Related Disorders -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68227248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Linking+opioid-dependent+hospital+patients+to+drug+treatment%3A+Health+care+use+and+costs+6+months+after+randomization.&rft.au=Barnett%2C+Paul+G%3BMasson%2C+Carmen+L%3BSorensen%2C+James+L%3BWong%2C+Wynnie%3BHall%2C+Sharon&rft.aulast=Barnett&rft.aufirst=Paul&rft.date=2006-12-01&rft.volume=101&rft.issue=12&rft.spage=1797&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-10 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification, regulation and anti-proliferative role of the NPR-C receptor in gastric epithelial cells. AN - 68196047; 16786190 AB - Evidence suggests that functional atrial natriuretic peptide (ANP) receptors occur in surface gastric mucosal epithelial cells. To evaluate functional aspects of ANP in a model of these cells we examined the expression of natriuretic peptide receptors (NPR) subtypes A and C in the non-transformed rat gastric mucosal epithelial cell line RGM1. Transcripts for NPR-A and NPR-C were detected in RGM1 cells by RT-PCR. However, only NPR-C protein was detected by Western blot and immunohistochemical analyses. Specific saturable binding of (125)I-ANP to RGM1 cells revealed a single class of high affinity binding sites (K (d) = 208 +/- 71pM, B (max) = 110,000 +/- 14,000 sites/cell, Hill coefficient = 0.97 +/- 0.05). ANP (IC(50) 130 +/- 47pM), BNP (IC(50) 716 +/- 26 pM), CNP (IC(50) 356 +/- 85pM) and C-ANP (IC(50) 134 +/- 13pM), a specific ligand for NPR-C, effectively displaced (125)I-ANP binding. Cross-linking of (125)I-ANP to cells labeled predominantly a protein of 66,000 Da. These data suggest that (125)I-ANP binding was primarily to NPR-C. ANP and C-ANP inhibited forskolin- and prostaglandin E(2) (PGE(2))-stimulated cAMP in a PTx-sensitive fashion. PGE(2), transforming growth factor-+/-1 (TGF-+/-1), forskolin, 8-bromo-cyclic AMP, and phorbol-12-myristate-13-acetate (PMA) caused a dose-dependent decrease in specific (125)I-ANP binding, whereas epidermal growth factor (EGF), 8-bromo-cyclic GMP and 4+/--phorbol didecanoate had no effect. PGE(2), forskolin, TGF-+/-1 and PMA significantly decreased (125)I-ANP B (max) values, NPR-C protein and steady-state NPR-C transcript levels. H89, a protein kinase A inhibitor, blocked the reduction of NPR-C mRNA produced by both forskolin and PGE(2.) GF109203X, a protein kinase C inhibitor, abolished the PMA-induced decrease in NPR-C transcripts but only partially blocked that produced by TGF-+/-1. RGM1 cells exhibited a dose-dependent decrease in both DNA synthesis and cell proliferation when cultured in the presence of ANP or C-ANP. These findings indicate that RGM1 cells express functional NPR-C receptors that can influence RGM1 cell proliferation and are down-regulated by PGE(2) and TGF-+/-1. JF - Molecular and cellular biochemistry AU - Gower, William R AU - Carter, Gay M AU - McAfee, Quentin AU - Solivan, Suzanne M AD - Surgery and Research Services, James A. Haley Veterans Administration Hospital, 13000 Bruce B. Downs Boulevard, Tampa, FL 33612-4745, USA. wgower@health.usf.edu Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 103 EP - 118 VL - 293 IS - 1-2 SN - 0300-8177, 0300-8177 KW - RNA, Messenger KW - 0 KW - Transforming Growth Factor beta1 KW - Colforsin KW - 1F7A44V6OU KW - Atrial Natriuretic Factor KW - 85637-73-6 KW - Protein Kinases KW - EC 2.7.- KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Receptors, Atrial Natriuretic Factor KW - EC 4.6.1.2 KW - atrial natriuretic factor receptor C KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Dinoprostone -- pharmacology KW - Dose-Response Relationship, Drug KW - Adenylyl Cyclases -- metabolism KW - Cell Proliferation KW - Rats KW - Protein Kinases -- metabolism KW - Colforsin -- pharmacology KW - RNA, Messenger -- metabolism KW - Down-Regulation KW - Rats, Wistar KW - Atrial Natriuretic Factor -- metabolism KW - Protein Kinases -- genetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Transforming Growth Factor beta1 -- pharmacology KW - Fluorescent Antibody Technique KW - Male KW - Epithelial Cells -- metabolism KW - Receptors, Atrial Natriuretic Factor -- genetics KW - Receptors, Atrial Natriuretic Factor -- metabolism KW - Gastric Mucosa -- cytology KW - Gastric Mucosa -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68196047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biochemistry&rft.atitle=Identification%2C+regulation+and+anti-proliferative+role+of+the+NPR-C+receptor+in+gastric+epithelial+cells.&rft.au=Gower%2C+William+R%3BCarter%2C+Gay+M%3BMcAfee%2C+Quentin%3BSolivan%2C+Suzanne+M&rft.aulast=Gower&rft.aufirst=William&rft.date=2006-12-01&rft.volume=293&rft.issue=1-2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biochemistry&rft.issn=03008177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-16 N1 - Date created - 2006-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predictors of neuroleptic-induced dyskinesia and parkinsonism: the influence of measurement methods and definitions. AN - 68162975; 17110811 AB - The accurate and objective measurement of abnormal, involuntary movements remains highly desirable, whether the movements are secondary to pharmacotherapy or an expression of the primary illness. In a previous study, we found that the prevalence of tardive dyskinesia in a sample of 100 subjects ranged from 28% when using the Abnormal Involuntary Movement Scale (AIMS) or the Dyskinesia Identification Scale, Condensed User Version (DISCUS) to 62% using an instrumental measurement (IM) of peripheral dyskinesia. The goal of this study was to examine the relationship between various risk factors for tardive dyskinesia as predictor variables, and the AIMS, DISCUS, and IMs of dyskinesia, tremor, and velocity of motor movement as dependent variables. The sample consisted of 100, mostly patients with schizophrenia. Poor performance on the Mini-Mental State Examination (MMSE) and increasing age were the most consistent predictors of dyskinetic and parkinsonian movements. Various predictors were associated with specific abnormal movements. Head injury was related to slower speed of motor movements and the total DISCUS score. A history of smoking was associated with less IM dyskinesia. For those with coexisting parkinsonism and dyskinesia, significant associations were found with head injury, diabetes mellitus, and an AIMS score of 2 or greater in 2 body areas. Various classes of psychotropic agents seemed to have little influence on the MMSE or the development of dyskinesia and parkinsonism. Increasing age and a lower score on the MMSE seem to be particularly helpful in gauging the risk for parkinsonian and dyskinetic movements. JF - Journal of clinical psychopharmacology AU - Dean, Charles E AU - Kuskowski, Michael A AU - Caligiuri, Michael P AD - Psychiatric Movement Disorders Clinic, Minneapolis Veterans Affairs Medical Center, MN 55417, USA. charles.dean@med.va.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 560 EP - 565 VL - 26 IS - 6 SN - 0271-0749, 0271-0749 KW - Antipsychotic Agents KW - 0 KW - Chlorpromazine KW - U42B7VYA4P KW - Index Medicus KW - Age Factors KW - Humans KW - Aging KW - Smoking -- adverse effects KW - Aged KW - Predictive Value of Tests KW - Risk Assessment KW - Age Distribution KW - Chlorpromazine -- adverse effects KW - Cross-Sectional Studies KW - Psychiatric Status Rating Scales KW - Logistic Models KW - Risk Factors KW - Adult KW - Middle Aged KW - Craniocerebral Trauma -- complications KW - Female KW - Male KW - Prevalence KW - Parkinson Disease, Secondary -- chemically induced KW - Diabetes Complications -- chemically induced KW - Parkinson Disease, Secondary -- epidemiology KW - Dyskinesia, Drug-Induced -- epidemiology KW - Dyskinesia, Drug-Induced -- etiology KW - Neuropsychological Tests KW - Antipsychotic Agents -- adverse effects KW - Parkinson Disease, Secondary -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68162975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Predictors+of+neuroleptic-induced+dyskinesia+and+parkinsonism%3A+the+influence+of+measurement+methods+and+definitions.&rft.au=Dean%2C+Charles+E%3BKuskowski%2C+Michael+A%3BCaligiuri%2C+Michael+P&rft.aulast=Dean&rft.aufirst=Charles&rft.date=2006-12-01&rft.volume=26&rft.issue=6&rft.spage=560&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-07 N1 - Date created - 2006-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New instrumentation for automated tinnitus psychoacoustic assessment. AN - 68161395; 17114140 AB - Although tinnitus is a major health problem, techniques to quantify its perceptual aspects are not standardized. This study represents a key step in our efforts to develop clinical methodology to accurately and reliably quantify the sensation of tinnitus, using a uniform method for obtaining a battery of tinnitus measures. The purpose of this study was to evaluate the performance of the automated system, which was redesigned to reduce time of testing and to add new testing capabilities. The primary difference in function was the use of a 'knob' device that enabled patient control of auditory stimuli. The new tests included assessment of minimum masking level (MML) and residual inhibition (RI). As with previous iterations of the system, a computer program ran all testing and subjects read instructions and provided responses via a computer touch-screen. Three separate studies were conducted. Study 1 evaluated within- and between-session test-retest response reliability of tinnitus loudness matches (LMs) and pitch matches (PMs). Study 2 was conducted to evaluate differences in LMs and PMs between subjects with and without tinnitus - to obtain pilot data to assist in the development of a test for 'tinnitus malingering.' Study 3 evaluated the system's capability of obtaining MMLs and RI as well as the between-session reliability of these measures. Study 1 documented that the new system could obtain LMs and PMs within approximately 20 min, while maintaining clinically acceptable reliability. Study 2 revealed characteristic differences in LM and PM test results for individuals who did not experience tinnitus. Study 3 documented the system's ability to obtain measures of MML and RI that were reliable across sessions. JF - Acta oto-laryngologica. Supplementum AU - Henry, J A AU - Rheinsburg, B AU - Owens, K K AU - Ellingson, R M AD - VA RR&D National Center for Rehabilitative Auditory Research, VA Medical Center (VAMC), Portland, OR, USA. james.henry@med.va.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 34 EP - 38 IS - 556 SN - 0365-5237, 0365-5237 KW - Index Medicus KW - Severity of Illness Index KW - Auditory Threshold -- physiology KW - Malingering -- epidemiology KW - Perceptual Masking -- physiology KW - Reproducibility of Results KW - Hearing Disorders -- epidemiology KW - Humans KW - Diagnosis, Computer-Assisted KW - Hearing Disorders -- diagnosis KW - Malingering -- diagnosis KW - Pilot Projects KW - Equipment Design KW - Noise KW - Psychoacoustics KW - Middle Aged KW - Female KW - Male KW - Tinnitus -- physiopathology KW - Tinnitus -- diagnosis KW - Otolaryngology -- instrumentation KW - Tinnitus -- epidemiology KW - Automatic Data Processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68161395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+oto-laryngologica.+Supplementum&rft.atitle=New+instrumentation+for+automated+tinnitus+psychoacoustic+assessment.&rft.au=Henry%2C+J+A%3BRheinsburg%2C+B%3BOwens%2C+K+K%3BEllingson%2C+R+M&rft.aulast=Henry&rft.aufirst=J&rft.date=2006-12-01&rft.volume=&rft.issue=556&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Acta+oto-laryngologica.+Supplementum&rft.issn=03655237&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-08 N1 - Date created - 2006-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adrenergic blocker carvedilol attenuates the cardiovascular and aversive effects of nicotine in abstinent smokers. AN - 68155356; 17110799 AB - The cardiovascular response to nicotine is mediated mainly by noradrenergic activation. Whether noradrenergic activation mediates other effects of nicotine has not been well documented in humans. In this study, we examined the effects of an alpha and beta-adrenergic receptor blocker: carvedilol, on cardiovascular and subjective responses to nicotine lozenge and on the ability of nicotine lozenge to suppress tobacco withdrawal symptoms in overnight abstinent smokers. Fifteen smokers, nine men and six women, participated in a double-blind, placebo-controlled, crossover study. In each of the three experimental sessions, participants were treated orally with a single 25 or 50 mg dose of carvedilol or placebo. Two hours and 10 min following the medication treatment, participants received a single 4 mg nicotine lozenge. Carvedilol treatment attenuated the nicotine-induced heart rate, systolic and diastolic blood pressure increases. Carvedilol also attenuated the self-report rating of 'bad effects' in response to nicotine. Carvedilol, alone or in combination with nicotine lozenge, did not affect tobacco withdrawal symptoms. Carvedilol treatment did not affect performance on the Stroop Test. These results support the effectiveness of carvedilol for attenuating the cardiovascular effects of nicotine. Attenuation of the rating of 'bad effects' by carvedilol suggests that noradrenergic activation may also mediate the aversive effects of nicotine. JF - Behavioural pharmacology AU - Sofuoglu, Mehmet AU - Mouratidis, Maria AU - Yoo, Sonah AU - Kosten, Thomas AD - Department of Psychiatry and Veterans Administration Connecticut Healthcare System, School of Medicine, Yale University, West Haven, CT 06515, USA. Mehmet.Sofuoglu@yale.edu Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 731 EP - 735 VL - 17 IS - 8 SN - 0955-8810, 0955-8810 KW - Adrenergic Antagonists KW - 0 KW - Carbazoles KW - Ganglionic Stimulants KW - Propanolamines KW - carvedilol KW - 0K47UL67F2 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Tobacco Use Disorder -- physiopathology KW - Heart Rate -- drug effects KW - Substance Withdrawal Syndrome -- physiopathology KW - Tobacco Use Disorder -- drug therapy KW - Ganglionic Stimulants -- adverse effects KW - Double-Blind Method KW - Humans KW - Adult KW - Cross-Over Studies KW - Substance Withdrawal Syndrome -- drug therapy KW - Blood Pressure -- drug effects KW - Male KW - Female KW - Adrenergic Antagonists -- pharmacology KW - Smoking Cessation KW - Nicotine -- adverse effects KW - Carbazoles -- pharmacology KW - Propanolamines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68155356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+pharmacology&rft.atitle=Adrenergic+blocker+carvedilol+attenuates+the+cardiovascular+and+aversive+effects+of+nicotine+in+abstinent+smokers.&rft.au=Sofuoglu%2C+Mehmet%3BMouratidis%2C+Maria%3BYoo%2C+Sonah%3BKosten%2C+Thomas&rft.aulast=Sofuoglu&rft.aufirst=Mehmet&rft.date=2006-12-01&rft.volume=17&rft.issue=8&rft.spage=731&rft.isbn=&rft.btitle=&rft.title=Behavioural+pharmacology&rft.issn=09558810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-13 N1 - Date created - 2006-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Psychometric Characteristics of Role-Play Assessments of Social Skill in Schizophrenia AN - 57289307; 200913742 AB - There is an extensive literature documenting that people with schizophrenia have marked impairments in social role functioning and social skill. One of the most widely employed strategies for assessing social skill has been role-play tests: simulated social interactions that are videotaped for subsequent behavioral coding. There has been considerable discussion of the validity of the approach in the literature, but there has not been adequate consideration of other psychometric characteristics of role-play tests. This paper examines the psychometric characteristics of a representative role-play measure: the Maryland Assessment of Social Competence (MASC). Data from 5 large schizophrenia studies that included the MASC were examined: a study of victimization in women who abuse drugs, a study of health care among people with diabetes, a study of vocational outcomes, a study of social skill among drug abusers, and a clinical trial comparing two antipsychotic medications. Data were examined in terms of five questions: (1) Can role-play scenes be rated reliably? (2) How are role-play ratings distributed across populations? (3) How many and which behaviors should be rated? (4) How many role-play scenes are required? (5) Is role-play behavior temporally stable? Overall, the data suggest that the MASC, and by implication other similar role-play procedures, does have good psychometric properties. However, several things often taken for granted in the literature warrant careful consideration in the design of research using role-play. Implications of the results for design of research are discussed. [Copyright Association for Behavioral and Cognitive Therapies. Published by Elsevier Ltd.] JF - Behavior Therapy AU - Bellack, Alan S AU - Brown, Clayton H AU - Thomas-Lohrman, Shannon AD - University of Maryland School of Medicine and VA Capitol Health Care Network MIRECC alan.bellack@va.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 339 EP - 352 PB - Elsevier Ltd, The Netherlands VL - 37 IS - 4 SN - 0005-7894, 0005-7894 KW - Assessment KW - Schizophrenia KW - Social skills KW - Psychometric properties KW - Clinical trials KW - Psychometrics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57289307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Therapy&rft.atitle=Psychometric+Characteristics+of+Role-Play+Assessments+of+Social+Skill+in+Schizophrenia&rft.au=Bellack%2C+Alan+S%3BBrown%2C+Clayton+H%3BThomas-Lohrman%2C+Shannon&rft.aulast=Bellack&rft.aufirst=Alan&rft.date=2006-12-01&rft.volume=37&rft.issue=4&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Behavior+Therapy&rft.issn=00057894&rft_id=info:doi/10.1016%2Fj.beth.2006.01.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Social skills; Psychometrics; Schizophrenia; Assessment; Clinical trials; Psychometric properties DO - http://dx.doi.org/10.1016/j.beth.2006.01.005 ER - TY - JOUR T1 - Psychological Pain: A Review of Evidence AN - 57219322; 200717520 AB - This paper defines a symptom construct termed psychological pain & reviews clinical & neuroimaging evidence relevant to it. The psychological pain associated with severe depression is often perceived as worse than any physical pain that the individual has experienced & could be a critical component of suicidality that could be systematically assessed in potentially suicidal patients. Converging evidence from brain imaging studies suggests overlapping patterns of brain activation induced by both psychological pain & by physical pain. Future research on the role of psychological pain & its interaction with nociceptive pathways may provide novel clues to the understanding & treatment of depression & other psychiatric illnesses. Tables, Figures, References. [Copyright 2006 Elsevier Ltd.] JF - Journal of Psychiatric Research AU - Mee, Steven AU - Bunney, Blynn G AU - Reist, Christopher AU - Potkin, Steve G AU - Bunney, William E AD - Dept Psychiatry, Long Beach VA Medical Center, CA Steven.mee@med.va.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 680 EP - 690 PB - Elsevier Ltd, Oxford UK VL - 40 IS - 8 SN - 0022-3956, 0022-3956 KW - Psychological pain KW - Physical pain KW - Brain imaging KW - Suicidality KW - Depression KW - Suicidal ideation KW - Pain KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57219322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychiatric+Research&rft.atitle=Psychological+Pain%3A+A+Review+of+Evidence&rft.au=Mee%2C+Steven%3BBunney%2C+Blynn+G%3BReist%2C+Christopher%3BPotkin%2C+Steve+G%3BBunney%2C+William+E&rft.aulast=Mee&rft.aufirst=Steven&rft.date=2006-12-01&rft.volume=40&rft.issue=8&rft.spage=680&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychiatric+Research&rft.issn=00223956&rft_id=info:doi/10.1016%2Fj.jpsychires.2006.03.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-09-28 N1 - Last updated - 2016-09-27 N1 - CODEN - JPYRA3 N1 - SubjectsTermNotLitGenreText - Depression; Pain; Suicidal ideation; Brain imaging DO - http://dx.doi.org/10.1016/j.jpsychires.2006.03.003 ER - TY - JOUR T1 - Efficient interval estimation for age-adjusted cancer rates AN - 57183981; 200710310 AB - The age-adjusted cancer rates are defined as the weighted average oft age-specific cancer rates, where the weights are positive, known, and normalized so that their sum is 1. Fay and Feuer developed a confidence interval for a single age-adjusted rate based on the gamma approximation. Fay used the gamma approximations to construct an F interval for the ratio of two age-adjusted rates. Modifications of the gamma and F intervals are proposed and a simulation study is carried out to show that these modified gamma and modified F intervals are more efficient than the gamma and F intervals, respectively, in the sense that the proposed intervals have empirical coverage probabilities less than or equal to their counterparts, and that they also retain the nominal level. The normal and beta confidence intervals for a single age-adjusted rate are also provided, but they are shown to be slightly liberal. Finally, for comparing two correlated age-adjusted rates, the confidence intervals for the difference and for the ratio of the two age-adjusted rates are derived incorporating the correlation between the two rates. The proposed gamma and F intervals and the normal intervals for the correlated age-adjusted rates are recommended to be implemented in the Surveillance, Epidemiology and End Results Program of the National Cancer Institute. Adapted from the source document. JF - Statistical Methods in Medical Research AU - Tiwari, Ram C AU - Clegg, Limin X AU - Zou, Zhaohui Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 547 EP - 569 PB - Hodder Arnold, London UK VL - 15 IS - 6 SN - 0962-2802, 0962-2802 KW - Age KW - Rates KW - Cancer KW - Confidence intervals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57183981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Efficient+interval+estimation+for+age-adjusted+cancer+rates&rft.au=Tiwari%2C+Ram+C%3BClegg%2C+Limin+X%3BZou%2C+Zhaohui&rft.aulast=Tiwari&rft.aufirst=Ram&rft.date=2006-12-01&rft.volume=15&rft.issue=6&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280206070621 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Confidence intervals; Cancer; Age; Rates DO - http://dx.doi.org/10.1177/0962280206070621 ER - TY - JOUR T1 - SHORT COMMUNICATION: Dose selection and pharmacokinetics of rifampin in elephants for the treatment of tuberculosis AN - 21121770; 7219755 JF - Journal of Veterinary Pharmacology and Therapeutics AU - Peloquin, CA AU - Maslow, J N AU - Mikota, S K AU - Forrest, A AU - Dunker, F AU - Isaza, R AU - Peddie, L R AU - Peddie, J AU - Zhu, M AD - Section of Infectious Diseases, VA Medical Center and the Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA, USA, joel.maslow@va.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 581 EP - 585 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 29 IS - 6 SN - 0140-7783, 0140-7783 KW - Microbiology Abstracts B: Bacteriology KW - Rifampin KW - Mycobacterium KW - Elephantidae KW - Tuberculosis KW - Pharmacokinetics KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21121770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.atitle=SHORT+COMMUNICATION%3A+Dose+selection+and+pharmacokinetics+of+rifampin+in+elephants+for+the+treatment+of+tuberculosis&rft.au=Peloquin%2C+CA%3BMaslow%2C+J+N%3BMikota%2C+S+K%3BForrest%2C+A%3BDunker%2C+F%3BIsaza%2C+R%3BPeddie%2C+L+R%3BPeddie%2C+J%3BZhu%2C+M&rft.aulast=Peloquin&rft.aufirst=CA&rft.date=2006-12-01&rft.volume=29&rft.issue=6&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.issn=01407783&rft_id=info:doi/10.1111%2Fj.1365-2885.2006.00789.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - SuppNotes - Figures, 4; tables, 2. N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Rifampin; Tuberculosis; Pharmacokinetics; Mycobacterium; Elephantidae DO - http://dx.doi.org/10.1111/j.1365-2885.2006.00789.x ER - TY - JOUR T1 - The Bacteroides fragilis cell envelope: Quarterback, linebacker, coach--or all three? AN - 20536244; 9214880 AB - Bacteroides fragilis is an anaerobic commensal constituting only 1-2% of the micro-flora of the human gastrointestinal tract, yet it is the predominant anaerobic isolate in cases of intraabdominal sepsis and bacteremia. B. fragilis can play two roles in the host: in its role as friendly commensal, it must be able to establish itself in the host intestinal mucosa, to utilize and process polysaccharides for use by the host, and to resist the noxious effects of bile salts. In its role as pathogen, it must be able to attach itself to the site of infection, evade killing mechanisms by host defense, withstand antimicrobial treatment and produce factors that damage host tissue. The cell envelope of B. fragilis, likewise, must be able to function in the roles of aggressor, defender and strategist in allowing the organism to establish itself in the host--whether as friend or foe. Recent studies of the genomes and proteomes of the genus Bacteroides suggest that these organisms have evolved strategies to survive and dominate in the overcrowded gastrointestinal neighborhood. Analysis of the proteomes of S. fragilis and Bacteroides thetaiotaomicron demonstrates both a tremendous capacity to use a wide range of dietary polysaccharides, and the capacity to create variable surface antigenicities by multiple DNA inversion systems. The latter characteristic is particularly pronounced in the species B. fragilis, which is more frequently found at the mucosal surface (i.e., often the site of attack by host defenses). The B. fragilis cell envelope undergoes major protein expression and ultrastructural changes in response to stressors such as bile or antimicrobial agents. These agents may also act as signals for attachment and colonization. Thus the bacterium manages its surface characteristics to enable it to bind to its target, to use the available nutrients, and to avoid or evade hostile forces (host-derived or external) in its multiple roles. JF - Anaerobe AU - Pumbwe, L AU - Skilbeck, CA AU - Wexler, H M AD - Greater Los Angeles Veterans Administration Healthcare Systems and Department of Medicine, University of California, Los Angeles, CA, USA Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 211 EP - 220 VL - 12 IS - 5-6 SN - 1075-9964, 1075-9964 KW - Microbiology Abstracts B: Bacteriology KW - Genomes KW - Bacteroides fragilis KW - Bacteroides thetaiotaomicron KW - Lymphocytes B KW - Antigenicity KW - Cell envelopes KW - Mucosa KW - Commensals KW - Bacteremia KW - Nutrients KW - Pathogens KW - Infection KW - Polysaccharides KW - Antimicrobial agents KW - Colonization KW - Sepsis KW - Inversion KW - Bile salts KW - Bile KW - DNA KW - Intestine KW - Gastrointestinal tract KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20536244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=The+Bacteroides+fragilis+cell+envelope%3A+Quarterback%2C+linebacker%2C+coach--or+all+three%3F&rft.au=Pumbwe%2C+L%3BSkilbeck%2C+CA%3BWexler%2C+H+M&rft.aulast=Pumbwe&rft.aufirst=L&rft.date=2006-12-01&rft.volume=12&rft.issue=5-6&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=10759964&rft_id=info:doi/10.1016%2Fj.anaerobe.2006.09.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Antigenicity; Lymphocytes B; Cell envelopes; Mucosa; Commensals; Bacteremia; Nutrients; Pathogens; Polysaccharides; Infection; Antimicrobial agents; Colonization; Sepsis; Bile salts; Inversion; Bile; Intestine; DNA; Gastrointestinal tract; Bacteroides fragilis; Bacteroides thetaiotaomicron DO - http://dx.doi.org/10.1016/j.anaerobe.2006.09.004 ER - TY - JOUR T1 - Locomotor training: Experiencing the changing body AN - 19626752; 7361343 AB - This study examined the experiences of persons with incomplete spinal cord injury who participated in loco-motor training (LT). LT is an emerging rehabilitation intervention for enhancing the recovery of walking in persons with central nervous system disorders. Multiple interviews and field observations provided data from eight participants, including four veterans. Findings indicate that experiences of bodily changes were prevalent among participants. Themes included (1) experiencing impaired or absent proprioception, (2) struggling for bodily control, and (3) experiencing emergent bodily sensations. Themes 1 and 2 reflected bodily disruption as a result of spinal cord injury and were challenging to participants as they attempted to reconnect the body and self through LT. Theme 3 reflected bodily sensations (burning, soreness) that were seen as positive signs of recovery and resulted in hope and motivation. Understanding how LT participants experience bodily changes may enable therapists to develop improved participant-centered intervention approaches. JF - Journal of Rehabilitation Research and Development AU - Hannold, E M AU - Young, ME AU - Rittman, M R AU - Bowden, M G AU - Behrman, AL AD - VA Rehabilitation Outcomes Research Center, North Florida/South Georgia Veterans Health System, 1601 SW Archer Road, Mail Stop 151B, Gainesville, FL 32608, USA, Lisa.Hannold@med.va.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 905 EP - 916 VL - 43 IS - 7 SN - 0748-7711, 0748-7711 KW - Physical Education Index KW - Experience KW - Nervous system KW - Spine KW - Soreness KW - Injuries KW - Rehabilitation KW - Motivation KW - Recovery KW - Walking KW - Observation KW - Interviews KW - PE 110:Physical Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19626752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Locomotor+training%3A+Experiencing+the+changing+body&rft.au=Hannold%2C+E+M%3BYoung%2C+ME%3BRittman%2C+M+R%3BBowden%2C+M+G%3BBehrman%2C+AL&rft.aulast=Hannold&rft.aufirst=E&rft.date=2006-12-01&rft.volume=43&rft.issue=7&rft.spage=905&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2005.07.0122 LA - English DB - Physical Education Index N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Experience; Nervous system; Soreness; Spine; Motivation; Rehabilitation; Injuries; Recovery; Walking; Observation; Interviews DO - http://dx.doi.org/10.1682/JRRD.2005.07.0122 ER - TY - JOUR T1 - Emerging Therapeutic Strategies for Obesity AN - 19515778; 7207240 AB - The rising tide of obesity is one of the most pressing health issues of our time, yet existing medicines to combat the problem are disappointingly limited in number and effectiveness. Fortunately, a recent burgeoning of mechanistic insights into the neuroendocrine regulation of body weight provides an expanding list of molecular targets for novel, rationally designed antiobesity pharmaceuticals. In this review, we articulate a set of conceptual principles that we feel could help prioritize among these molecules in the development of obesity therapeutics, based on an understanding of energy homeostasis. We focus primarily on central targets, highlighting selected strategies to stimulate endogenous catabolic signals or inhibit anabolic signals. Examples of the former approach include methods to enhance central leptin signaling through intranasal leptin delivery, use of superpotent leptin-receptor agonists, and mechanisms to increase leptin sensitivity by manipulating SOCS-3, PTP-1B, ciliary neurotrophic factor, or simply by first losing weight with traditional interventions. Techniques to augment signaling by neurochemical mediators of leptin action that lie downstream of at least some levels of obesity-associated leptin resistance include activation of melanocortin receptors or 5-HT2C and 5-HT1B receptors. We also describe strategies to inhibit anabolic molecules, such as neuropeptide Y, melanin-concentrating hormone, ghrelin, and endocannabinoids. Modulation of gastrointestinal satiation and hunger signals is discussed as well. As scientists continue to provide fundamental insights into the mechanisms governing body weight, the future looks bright for development of new and better antiobesity medications to be used with diet and exercise to facilitate substantial weight loss. JF - Endocrine Reviews AU - Foster-Schubert, Karen E AU - Cummings, David E AD - Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108 Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 779 EP - 793 PB - Endocrine Society, 8401 Connecticut Ave Suite 900 Chevy Chase MD 20815-5817 USA, [mailto:societyservices@endo-society.org], [URL:http://www.endo-society.org/] VL - 27 IS - 7 SN - 0163-769X, 0163-769X KW - Physical Education Index; CSA Neurosciences Abstracts KW - Neuropeptide Y KW - Ciliary neurotrophic factor KW - Winning KW - Melanocortin receptors KW - Medications KW - Techniques KW - Health KW - Hormones KW - Neuromodulation KW - ghrelin KW - Cannabinoids KW - Serotonin S1 receptors KW - Body weight KW - Hunger KW - Diets KW - Obesity KW - Satiety KW - Weight control KW - Strategy KW - Diet (weight control) KW - Drug development KW - Exercise KW - Serotonin S2 receptors KW - Physical training KW - Leptin KW - Energy balance KW - Reviews KW - Pharmaceuticals KW - Medicine KW - Melanin-concentrating hormone KW - Signal transduction KW - N3 11009:Neuroendocrinology KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19515778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrine+Reviews&rft.atitle=Emerging+Therapeutic+Strategies+for+Obesity&rft.au=Foster-Schubert%2C+Karen+E%3BCummings%2C+David+E&rft.aulast=Foster-Schubert&rft.aufirst=Karen&rft.date=2006-12-01&rft.volume=27&rft.issue=7&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=Endocrine+Reviews&rft.issn=0163769X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Obesity; Weight control; Winning; Strategy; Medications; Diet (weight control); Techniques; Medicine; Health; Exercise; Hormones; Diets; Hunger; Satiety; Neuropeptide Y; Ciliary neurotrophic factor; Melanocortin receptors; Drug development; Serotonin S2 receptors; Physical training; Leptin; Neuromodulation; ghrelin; Energy balance; Body weight; Serotonin S1 receptors; Cannabinoids; Reviews; Pharmaceuticals; Melanin-concentrating hormone; Signal transduction ER - TY - JOUR T1 - Racial Differences in 30-Day Mortality for Pulmonary Embolism AN - 19495936; 7190925 AB - OBJECTIVES: Previous studies reported a higher incidence of in-hospital mortality for Black patients who had pulmonary embolism than for White patients. We used a large statewide database to compare 30-day mortality (defined as death within 30 days from the date of latest hospital admission) for Black and White patients who were hospitalized because of pulmonary embolism. METHODS: The study cohort consisted of 15531 discharged patients who had been treated for pulmonary embolism at 186 Pennsylvania hospitals between January 2000 and November 2002. We used random-effects logistic regression to model 30-day mortality for Black and White patients, and adjusted for patient demographic and clinical characteristics. RESULTS: The unadjusted 30-day mortality rates were 9.0% for White patients, 10.3% for Blacks, and 10.9% for patients of other or unknown race. When adjusted for severity of disease using a validated clinical prognostic model for pulmonary embolism, Black patients had 30% higher odds of 30-day mortality compared with White patients at the same site (adjusted odds ratio = 1.3; 95% confidence interval, 1.1,1.6). Neither insurance status nor hospital volume was a significant predictor of 30-day mortality. CONCLUSION: Black patients who had pulmonary embolism had significantly higher odds of 30-day mortality compared with White patients. JF - American Journal of Public Health AU - Ibrahim, Said A AU - Stone, Roslyn A AU - Obrosky, DScott AU - Sartorius, Jennifer AU - Fine, Michael J AU - Aujesky, Drahomir AD - Said A. Ibrahim, Michael J. Fine, Roslyn A. Stone, D. Scott Obrosky, and Jennifer Sartorius are with the Veterans Administration Center for Health Equity Research and Promotion, Pittsburgh Healthcare System, Pittsburgh, Pa. Said A. Ibrahim, Michael J. Fine, and D. Scott Obrosky are also with the Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh. Roslyn A. Stone is also with the Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh. Drahomir Aujesky is with the Division of Internal Medicine, the Clinical Epidemiology Center, and the University Outpatient Clinic, University of Lausanne, Lausanne, Switzerland Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 2161 EP - 2164 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 96 IS - 12 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts KW - demography KW - Mortality KW - USA, Pennsylvania KW - Insurance KW - Hospitals KW - Public health KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19495936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Racial+Differences+in+30-Day+Mortality+for+Pulmonary+Embolism&rft.au=Ibrahim%2C+Said+A%3BStone%2C+Roslyn+A%3BObrosky%2C+DScott%3BSartorius%2C+Jennifer%3BFine%2C+Michael+J%3BAujesky%2C+Drahomir&rft.aulast=Ibrahim&rft.aufirst=Said&rft.date=2006-12-01&rft.volume=96&rft.issue=12&rft.spage=2161&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - demography; Mortality; Insurance; Public health; Hospitals; USA, Pennsylvania ER - TY - JOUR T1 - Clinically Localised Prostate Cancer AN - 57147840; 200705727 AB - Prostate cancer is the most commonly diagnosed cancer in United Kingdom men. In 2002 it was diagnosed in 32 000 men, and more than 10 000 deaths were attributed to it. Its incidence increased with the introduction of the prostate specific antigen (PSA) blood test, and disease specific mortality has declined. This review provides evidence about risk factors, prevention, detection, natural course, and treatment, with a focus on clinically localised disease, to guide primary care doctors. Figures, References. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Wilt, Timothy J AU - Thompson, Ian M AD - Minneapolis VA Center Chronic Disease Outcomes Research, MN Tim.wilt@med.va.gov Y1 - 2006/11/25/ PY - 2006 DA - 2006 Nov 25 SP - 1102 EP - 1106 PB - British Medical Association, BMJ Publishing Group, London UK VL - 333 IS - 7578 SN - 0959-535X, 0959-535X KW - Diagnosis KW - Pathology KW - Treatment KW - Prostatic cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57147840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Clinically+Localised+Prostate+Cancer&rft.au=Wilt%2C+Timothy+J%3BThompson%2C+Ian+M&rft.aulast=Wilt&rft.aufirst=Timothy&rft.date=2006-11-25&rft.volume=333&rft.issue=7578&rft.spage=1102&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.39022.423588.DE LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Prostatic cancer; Pathology; Diagnosis; Treatment DO - http://dx.doi.org/10.1136/bmj.39022.423588.DE ER - TY - JOUR T1 - Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease. AN - 68123581; 17064696 AB - Previous work has identified sphingosine kinase-1 (SK1) as a substrate for the cysteine protease cathepsin B in vitro. In this study, the mechanism of SK1 cleavage by cathepsin B was investigated. We identified two initial cleavage sites for the protease, the first at histidine 122 and the second at arginine 199. Mutation analysis showed that replacement of histidine 122 with a tyrosine maintained the activity of SK1 while significantly reducing cleavage by cathepsin B at the initial cleavage site. The efficacy of cleavage of SK1 at arginine 199, however, was not affected. These studies demonstrate that SK1 is cleaved by cathepsin B in a sequential manner after basic amino acids, and that the initial cleavages at the two identified sites occur independently of each other. JF - FEBS letters AU - Taha, Tarek A AU - El-Alwani, Mazen AU - Hannun, Yusuf A AU - Obeid, Lina M AD - Division of General Internal Medicine, Ralph H. Johnson Veterans Administration Hospital, Charleston, SC 29401, USA. Y1 - 2006/11/13/ PY - 2006 DA - 2006 Nov 13 SP - 6047 EP - 6054 VL - 580 IS - 26 SN - 0014-5793, 0014-5793 KW - Amino Acids, Basic KW - 0 KW - Histidine KW - 4QD397987E KW - Arginine KW - 94ZLA3W45F KW - Phosphotransferases (Alcohol Group Acceptor) KW - EC 2.7.1.- KW - sphingosine kinase KW - Cathepsin B KW - EC 3.4.22.1 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Transfection KW - Humans KW - Cell Line, Tumor KW - Binding Sites KW - Cathepsin B -- metabolism KW - Phosphotransferases (Alcohol Group Acceptor) -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68123581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Sphingosine+kinase-1+is+cleaved+by+cathepsin+B+in+vitro%3A+identification+of+the+initial+cleavage+sites+for+the+protease.&rft.au=Taha%2C+Tarek+A%3BEl-Alwani%2C+Mazen%3BHannun%2C+Yusuf+A%3BObeid%2C+Lina+M&rft.aulast=Taha&rft.aufirst=Tarek&rft.date=2006-11-13&rft.volume=580&rft.issue=26&rft.spage=6047&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-09 N1 - Date created - 2006-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cell Biol. 1999 Nov 1;147(3):545-58 [10545499] Methods Enzymol. 2000;311:215-23 [10563328] Biochim Biophys Acta. 2000 Mar 7;1477(1-2):98-111 [10708852] Leukemia. 2000 Sep;14(9):1695-703 [10995018] J Clin Invest. 2000 Nov;106(9):1127-37 [11067865] J Biol Chem. 2001 Feb 2;276(5):3149-57 [11073962] EMBO J. 2001 Sep 3;20(17):4629-33 [11532926] Blood. 2001 Nov 1;98(9):2828-36 [11675357] Prostate. 2001 Nov 1;49(3):172-84 [11746262] J Biol Chem. 2002 Apr 26;277(17):14829-37 [11815600] J Biol Chem. 2002 Aug 30;277(35):32220-7 [12072442] J Biol Chem. 2002 Sep 20;277(38):35257-62 [12124383] J Biol Chem. 2002 Dec 20;277(51):49545-53 [12393916] Cancer Metastasis Rev. 2003 Jun-Sep;22(2-3):271-86 [12785001] J Biol Chem. 2004 Jan 30;279(5):3578-87 [14581476] Oncogene. 2004 Apr 12;23(16):2746-56 [15077138] J Biol Chem. 2004 Sep 24;279(39):41012-7 [15262981] J Biol Chem. 1987 Oct 25;262(30):14448-53 [3312190] FEBS Lett. 1991 Aug 5;287(1-2):189-92 [1715285] Biol Chem. 1998 Feb;379(2):137-47 [9524065] J Biol Chem. 1998 May 22;273(21):13236-44 [9582368] FEBS Lett. 1998 Nov 6;438(3):150-8 [9827536] FEBS Lett. 2004 Dec 3;578(1-2):106-10 [15581625] J Biol Chem. 2005 Apr 29;280(17):17196-202 [15710602] J Cell Sci. 2005 Apr 1;118(Pt 7):1493-503 [15769846] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mental Health Screening Before Troop Deployment AN - 57103895; 200705220 AB - The United Kingdom and United States have a long history of trying to identify mental health problems among troops to be deployed. Since the first world war, a series of psychological screening programmes have been implemented, but none has been successful in providing a more capable combat force. Nevertheless, there is an understandable interest in developing new screening strategies to reduce the psychological morbidity of troops currently serving in Iraq and Afghanistan. In the current issue of the BMJ, Rona and colleagues report the effects of screening troops for mental health problems before deployment to Iraq. Two major approaches to predeployment screening exist. The first is to identify troops who are already experiencing debilitating medical and psychological illnesses just before deployment. The advantages of not sending sick troops into a conflict are obvious. These screening programmes are therefore useful, provided they accurately identify troops who need health care, are cost effective, and do not hinder demanding deployment preparations. The second is to identify soldiers who are considered healthy but who have a 'propensity' to break down in battle or develop chronic psychological problems. The study by Rona and colleagues evaluates the second approach and finds that a screening questionnaire administered to troops before deployment to Iraq was possibly useful for identifying post-traumatic stress disorder but not for other mental disorders. The marginal benefit was partly because the frequency of mental health problems was low among these troops, which is a common problem in screening generally healthy military populations. References. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Hyams, Kenneth Craig AD - Office Public Health & Environmental Hazards, U.S. Dept Veterans Affairs, Washington Kenneth.Hyams@va.gov Y1 - 2006/11/11/ PY - 2006 DA - 2006 Nov 11 SP - 979 EP - 980 PB - British Medical Association, BMJ Publishing Group, London UK VL - 333 IS - 7576 SN - 0959-535X, 0959-535X KW - Screening KW - USA KW - Mental health KW - UK KW - Military personnel KW - Deployment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57103895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Mental+Health+Screening+Before+Troop+Deployment&rft.au=Hyams%2C+Kenneth+Craig&rft.aulast=Hyams&rft.aufirst=Kenneth&rft.date=2006-11-11&rft.volume=333&rft.issue=7576&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.39023.648970.80 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Military personnel; Deployment; Mental health; Screening; UK; USA DO - http://dx.doi.org/10.1136/bmj.39023.648970.80 ER - TY - CPAPER T1 - Risk of Metabolic Syndrome in Low Dose Quetiapine T2 - 2006 Annual Meeting of International Society for Traumatic Stress Studies AN - 40501422; 4492585 JF - 2006 Annual Meeting of International Society for Traumatic Stress Studies AU - Johnson, Catherine AU - Vogel, Katrina AU - Juergens, Timothy AU - Ahearn, Eileen AU - Krahn, Dean Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Quetiapine KW - Metabolic disorders KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40501422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.atitle=Risk+of+Metabolic+Syndrome+in+Low+Dose+Quetiapine&rft.au=Johnson%2C+Catherine%3BVogel%2C+Katrina%3BJuergens%2C+Timothy%3BAhearn%2C+Eileen%3BKrahn%2C+Dean&rft.aulast=Johnson&rft.aufirst=Catherine&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.issn=&rft_id=info:doi/ L2 - http://www.istss.org/meetings/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ad Lib Smoking in Posttraumatic Stress Disorder: An Electronic Diary Study T2 - 2006 Annual Meeting of International Society for Traumatic Stress Studies AN - 40490185; 4492761 JF - 2006 Annual Meeting of International Society for Traumatic Stress Studies AU - Beckham, Jean AU - Wiley, Matthew AU - Dennis, Michelle AU - Miller, Susannah Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Psychology KW - Smoking KW - Post-traumatic stress disorder UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40490185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.atitle=Ad+Lib+Smoking+in+Posttraumatic+Stress+Disorder%3A+An+Electronic+Diary+Study&rft.au=Beckham%2C+Jean%3BWiley%2C+Matthew%3BDennis%2C+Michelle%3BMiller%2C+Susannah&rft.aulast=Beckham&rft.aufirst=Jean&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.issn=&rft_id=info:doi/ L2 - http://www.istss.org/meetings/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preventing Psychological and Moral Injury in Military Service T2 - 2006 Annual Meeting of International Society for Traumatic Stress Studies AN - 40485361; 4492442 JF - 2006 Annual Meeting of International Society for Traumatic Stress Studies AU - Shay, Jonathan AU - Stokes, James AU - Nash, William AU - Ritchie, Elspeth Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Psychology KW - Military KW - Injuries KW - Ethics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40485361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.atitle=Preventing+Psychological+and+Moral+Injury+in+Military+Service&rft.au=Shay%2C+Jonathan%3BStokes%2C+James%3BNash%2C+William%3BRitchie%2C+Elspeth&rft.aulast=Shay&rft.aufirst=Jonathan&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.issn=&rft_id=info:doi/ L2 - http://www.istss.org/meetings/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improving Identification and Treatment of Patients with Alcohol Problems T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39349268; 4463474 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Postiglione, Paul AU - Claiborne, Nancy AU - Videka, Lynn AU - Finkelstein, Allan AU - McDonnell, Patricia AU - Krause, Robin Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Alcohols KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39349268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Improving+Identification+and+Treatment+of+Patients+with+Alcohol+Problems&rft.au=Postiglione%2C+Paul%3BClaiborne%2C+Nancy%3BVideka%2C+Lynn%3BFinkelstein%2C+Allan%3BMcDonnell%2C+Patricia%3BKrause%2C+Robin&rft.aulast=Postiglione&rft.aufirst=Paul&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV/AIDS in Africa: Taking Health and Human Rights Seriously T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39297383; 4464547 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Shuster, Evelyne Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Africa KW - Human immunodeficiency virus KW - Human rights KW - Acquired immune deficiency syndrome KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39297383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=HIV%2FAIDS+in+Africa%3A+Taking+Health+and+Human+Rights+Seriously&rft.au=Shuster%2C+Evelyne&rft.aulast=Shuster&rft.aufirst=Evelyne&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characteristics of Mammography Facility Locations and Stage of Breast Cancer at Diagnosis in Chicago T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39288161; 4464260 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Tarlov, Elizabeth AU - Zenk, Shannon N AU - Warnecke, Richard AU - Campbell, Richard T AU - Block, Richard Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - USA, Illinois, Chicago KW - Breast cancer KW - Mammography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39288161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Characteristics+of+Mammography+Facility+Locations+and+Stage+of+Breast+Cancer+at+Diagnosis+in+Chicago&rft.au=Tarlov%2C+Elizabeth%3BZenk%2C+Shannon+N%3BWarnecke%2C+Richard%3BCampbell%2C+Richard+T%3BBlock%2C+Richard&rft.aulast=Tarlov&rft.aufirst=Elizabeth&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Public Health Reporting using ICD-10-CM T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39284260; 4461341 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Garvin, Jennifer H AU - Watzlaf, Valerie Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39284260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Evaluation+of+Public+Health+Reporting+using+ICD-10-CM&rft.au=Garvin%2C+Jennifer+H%3BWatzlaf%2C+Valerie&rft.aulast=Garvin&rft.aufirst=Jennifer&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Large-Area and Small-Area Variation in Follow-Up Strategies after Surgery for Upper Aerodigestive Tract Carcinoma T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39265963; 4461294 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Johnson, Frank E AU - Paniello, Randal C AU - Johnson, Michael H AU - Virgo, Katherine S Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Surgery KW - Carcinoma KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39265963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Large-Area+and+Small-Area+Variation+in+Follow-Up+Strategies+after+Surgery+for+Upper+Aerodigestive+Tract+Carcinoma&rft.au=Johnson%2C+Frank+E%3BPaniello%2C+Randal+C%3BJohnson%2C+Michael+H%3BVirgo%2C+Katherine+S&rft.aulast=Johnson&rft.aufirst=Frank&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Orleans Katrina and Paris Riots: Environmental and /or Social Debacle T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39265193; 4460859 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Shuster, Evelyne Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - France, Paris KW - USA, Louisiana, New Orleans KW - Risk assessment KW - Superfund KW - Environmental assessment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39265193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=New+Orleans+Katrina+and+Paris+Riots%3A+Environmental+and+%2For+Social+Debacle&rft.au=Shuster%2C+Evelyne&rft.aulast=Shuster&rft.aufirst=Evelyne&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Messages that Resonate: Nurses, the Public and the Implications of Changes in Nurse Supervisory Status T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39263400; 4464052 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Converso, Ann Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Nursing KW - Medical personnel KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39263400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Messages+that+Resonate%3A+Nurses%2C+the+Public+and+the+Implications+of+Changes+in+Nurse+Supervisory+Status&rft.au=Converso%2C+Ann&rft.aulast=Converso&rft.aufirst=Ann&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - VA Low Vision Intervention Trial T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39202196; 4463520 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Stelmack, Joan Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Vision KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39202196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=VA+Low+Vision+Intervention+Trial&rft.au=Stelmack%2C+Joan&rft.aulast=Stelmack&rft.aufirst=Joan&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The Use of Illustrations as an Adjunct to Administration of the COSI with Aging Patients AN - 85659845; 200801183 AB - The major goal of hearing aid dispensing is to reduce the perceived handicap resulting from hearing loss. To date, many self-assessment techniques have been designed to quantify the emotional & social effects of self-perceived hearing impairment in the noninstitutionalized elderly. A formalized procedure, the Client Oriented Scale of Improvement (COSI), has been used to document goals & needs & to measure improvements in the hearing ability of adult clients. The major advantage of this procedure is that there is greater focus on the client's individual needs when designing his or her rehabilitation program. Memory problems are one of the common complaints of the elderly. Over the years, research has shown that older individuals have particular difficulty with episodic memory, the conscious recollection of particular episodes or events that have occurred in a person's experience. This is supported by the finding that memory performance of older people is most affected when memory is tested using free recall of studied items, with smaller age-related reductions when memory is tested using recognition paradigms. The purpose of this study was to evaluate the efficacy of using pictures with the COSI to assist elderly subjects with hearing loss in recalling & identifying difficult listening situations in need of improvement with amplification. The study examined the responses of 30 older subjects ranging in age from 65 to 85 years who were all new hearing aid users. Adapted from the source document JF - Seminars in Hearing AU - Benjamin-McKie, Angela G AD - James J. Peters Veterans Administration Medical Center, Bronx, NY Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 330 EP - 336 VL - 27 IS - 4 SN - 0734-0451, 0734-0451 KW - Listening (48400) KW - Hearing Therapy (31580) KW - Elderly (21350) KW - Recall (Memory) (71700) KW - Visual Media (94550) KW - Self Evaluation (76550) KW - Measures (Instruments) (52300) KW - Hearing Aids (31250) KW - article KW - 6811: special education; hearing therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85659845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Hearing&rft.atitle=The+Use+of+Illustrations+as+an+Adjunct+to+Administration+of+the+COSI+with+Aging+Patients&rft.au=Benjamin-McKie%2C+Angela+G&rft.aulast=Benjamin-McKie&rft.aufirst=Angela&rft.date=2006-11-01&rft.volume=27&rft.issue=4&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Hearing&rft.issn=07340451&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2008-01-01 N1 - Last updated - 2016-09-27 N1 - CODEN - SEMHE7 N1 - SubjectsTermNotLitGenreText - Hearing Aids (31250); Hearing Therapy (31580); Elderly (21350); Self Evaluation (76550); Measures (Instruments) (52300); Visual Media (94550); Recall (Memory) (71700); Listening (48400) ER - TY - JOUR T1 - GI risk factors and use of GI protective agents among patients receiving nonsteroidal antiinflammatory drugs. AN - 69027779; 17047140 AB - Patient characteristics increase the risk of gastrointestinal (GI) complications associated with nonsteroidal antiinflammatory drugs (NSAIDs). Patients at risk may not be prescribed protective therapies that might mitigate their risk of NSAID-associated GI complications. To assess GI risk among Veterans Affairs (VA) patients on NSAID therapy, determine whether therapy conformed to VA guidelines for lessening the risk of GI complications, and identify patient risk factors associated with conformance. Using databases from 3 VA medical centers, we retrospectively identified patients receiving NSAIDs and obtained data regarding age, history of GI bleed over 8 years, GI adverse effects associated with NSAIDs, diagnoses, and medication history over one year. We inferred health status from age-adjusted Charlson comorbidity index values. Each patient's risk of developing GI complications over one year was calculated using these data. Among patients at significant or substantial risk, we assessed conformance to VA guidelines. We used logistic regression to identify risk factors associated with conformance and determine adjusted ORs (AORs) with 95% CIs for each risk factor. There were 19 122 patients receiving NSAIDs. Of 4589 patients at significant risk and 1246 at substantial risk, 1161 (25.3%) and 356 (28.6%), respectively, were prescribed guideline-conformant therapy. Risk factors associated with conformance (p < or = 0.001) among patients at significant risk were rheumatoid arthritis (AOR 1.34; 95% CI 1.13 to 1.58) and GI adverse effects (AOR 1.53; 95% CI 1.42 to 1.64). For substantial risk patients, risk factors associated with conformance (p < or = 0.031) were rheumatoid arthritis (AOR 1.65; 95% CI 1.37 to 1.98), concomitant corticosteroids (AOR 1.21; 95% CI 1.02 to 1.43), GI hospitalization (AOR 2.01; 95% CI 1.57 to 2.59), and GI adverse effects (AOR 1.79; 95% CI 1.47 to 2.18). Many patients at risk for GI adverse events do not receive guideline-conformant therapy. Educational interventions to improve conformance could focus on specific risk factors for GI complications. JF - The Annals of pharmacotherapy AU - Harris, Crystal L AU - Raisch, Dennis W AU - Abhyankar, Upendra AU - Marfatia, Shalaka AU - Campbell, Heather M AU - Sather, Mike R AD - Pharmaceutical Management and Research, Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy, Albuquerque, NM 87106-4180, USA. crystal.harris@csp.research.med.va.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1924 EP - 1931 VL - 40 IS - 11 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Gastrointestinal Agents KW - Protective Agents KW - Index Medicus KW - United States KW - Guidelines as Topic -- standards KW - Humans KW - Retrospective Studies KW - Aged KW - Aged, 80 and over KW - United States Department of Veterans Affairs KW - Risk Factors KW - Adult KW - Protective Agents -- therapeutic use KW - Databases, Factual KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Gastrointestinal Diseases -- chemically induced KW - Gastrointestinal Diseases -- prevention & control KW - Gastrointestinal Agents -- therapeutic use KW - Gastrointestinal Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69027779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=GI+risk+factors+and+use+of+GI+protective+agents+among+patients+receiving+nonsteroidal+antiinflammatory+drugs.&rft.au=Harris%2C+Crystal+L%3BRaisch%2C+Dennis+W%3BAbhyankar%2C+Upendra%3BMarfatia%2C+Shalaka%3BCampbell%2C+Heather+M%3BSather%2C+Mike+R&rft.aulast=Harris&rft.aufirst=Crystal&rft.date=2006-11-01&rft.volume=40&rft.issue=11&rft.spage=1924&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=1542-6270&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-08 N1 - Date created - 2006-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification and characterization of bicistronic speB and prsA gene expression in the group A Streptococcus. AN - 68973276; 16950917 AB - Severe, invasive group A streptococcal infections have reemerged worldwide, and extracellular toxins, including streptococcal pyrogenic exotoxin B (SpeB), have been implicated in pathogenesis. The genetic regulation of SpeB is not fully understood, and the mechanisms involved in the processing of the protoxin to its enzymatically active form have not been definitively established. The present work demonstrated that the genes encoding SpeB (speB) and a peptidyl-prolyl isomerase (prsA) constitute an operon with transcription initiated from two promoters upstream of speB. Further, the speB-prsA operon was transcribed as a bicistronic mRNA. This finding is in contrast to the generally accepted notion that speB is transcribed only as a monocistronic gene. In addition, prsA has its own promoter, and transcription from this promoter starts in early log phase, prior to the transcription of speB. Genomic disruption of prsA decreased the production of enzymatically active SpeB but not the level of the pro-SpeB zymogen. Taken together, these results demonstrate that prsA is required for production of fully mature, enzymatically active SpeB. JF - Journal of bacteriology AU - Ma, Yongsheng AU - Bryant, Amy E AU - Salmi, Dan B AU - Hayes-Schroer, Susan M AU - McIndoo, Eric AU - Aldape, Michael J AU - Stevens, Dennis L AD - Research & Development Service, Veterans Affairs Medical Center, 500 West Fort St., Bldg 45, Boise, ID 83702, USA. yongsheng.ma@va.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 7626 EP - 7634 VL - 188 IS - 21 SN - 0021-9193, 0021-9193 KW - Bacterial Proteins KW - 0 KW - Exotoxins KW - RNA, Bacterial KW - RNA, Messenger KW - erythrogenic toxin KW - Peptidylprolyl Isomerase KW - EC 5.2.1.8 KW - Index Medicus KW - Humans KW - Operon KW - Aged KW - Transcription, Genetic KW - RNA, Bacterial -- genetics KW - RNA, Messenger -- genetics KW - RNA, Messenger -- biosynthesis KW - Gene Deletion KW - Base Sequence KW - Promoter Regions, Genetic KW - RNA, Bacterial -- biosynthesis KW - Molecular Sequence Data KW - Male KW - Mutagenesis, Insertional KW - Gene Expression Regulation, Bacterial KW - Bacterial Proteins -- biosynthesis KW - Exotoxins -- biosynthesis KW - Streptococcus pyogenes -- genetics KW - Bacterial Proteins -- metabolism KW - Peptidylprolyl Isomerase -- genetics KW - Exotoxins -- metabolism KW - Peptidylprolyl Isomerase -- biosynthesis KW - Streptococcus pyogenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68973276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Identification+and+characterization+of+bicistronic+speB+and+prsA+gene+expression+in+the+group+A+Streptococcus.&rft.au=Ma%2C+Yongsheng%3BBryant%2C+Amy+E%3BSalmi%2C+Dan+B%3BHayes-Schroer%2C+Susan+M%3BMcIndoo%2C+Eric%3BAldape%2C+Michael+J%3BStevens%2C+Dennis+L&rft.aulast=Ma&rft.aufirst=Yongsheng&rft.date=2006-11-01&rft.volume=188&rft.issue=21&rft.spage=7626&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Microbiol. 1991 Aug;29(8):1562-7 [1684795] J Bacteriol. 2006 Jan;188(2):399-408 [16385029] Mol Microbiol. 1993 May;8(5):809-19 [8355608] Microb Pathog. 1993 Nov;15(5):327-46 [7516997] J Biol Chem. 1995 Apr 28;270(17):9862-7 [7730368] J Infect Dis. 1996 Apr;173(4):901-8 [8603969] J Exp Med. 1996 Aug 1;184(2):665-73 [8760820] Mol Microbiol. 1996 Sep;21(5):1087-99 [8885277] Med Microbiol Immunol. 1996 Nov;185(3):171-81 [9007823] Infect Immun. 1997 May;65(5):1956-9 [9125588] J Clin Invest. 1997 Jun 1;99(11):2574-80 [9169486] Microb Pathog. 2000 Apr;28(4):221-6 [10764613] J Mol Biol. 2000 Aug 4;301(1):27-33 [10926490] Mol Microbiol. 2000 Jun;36(6):1306-18 [10931281] J Infect Dis. 2000 Oct;182(4):1117-28 [10979908] Mol Microbiol. 2001 Jan;39(2):512-9 [11136470] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4658-63 [11296296] Infect Immun. 2001 Aug;69(8):4988-95 [11447177] J Infect Dis. 2001 Sep 15;184(6):723-31 [11517433] Infect Immun. 2001 Nov;69(11):6683-8 [11598038] J Biol Chem. 2003 May 9;278(19):17336-43 [12621045] J Bacteriol. 2003 Sep;185(17):5166-74 [12923089] Mol Microbiol. 2004 Jan;51(1):123-34 [14651616] Infect Immun. 2004 Mar;72(3):1618-25 [14977969] J Bacteriol. 1969 Sep;99(3):737-44 [5370276] J Clin Microbiol. 1976 May;3(5):533-6 [180049] Infect Immun. 1982 May;36(2):745-50 [7044976] J Hyg (Lond). 1985 Aug;95(1):47-57 [3926872] Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Aug;266(1-2):104-15 [3122461] J Bacteriol. 1989 May;171(5):2795-802 [2496115] N Engl J Med. 1989 Jul 6;321(1):1-7 [2659990] Infect Immun. 1998 Feb;66(2):771-6 [9453640] Mol Microbiol. 1998 Jun;28(6):1323-34 [9680220] EMBO J. 1998 Nov 2;17(21):6263-75 [9799235] Infect Immun. 1999 Apr;67(4):1715-22 [10085009] Eur J Biochem. 1999 Jul;263(1):145-51 [10429198] FEMS Immunol Med Microbiol. 1999 Sep;25(4):355-63 [10497866] Infect Immun. 1999 Oct;67(10):5298-305 [10496909] Infect Immun. 1999 Oct;67(10):5495-9 [10496938] J Bacteriol. 1999 Oct;181(19):6019-27 [10498714] Infect Immun. 2005 Feb;73(2):859-64 [15664926] J Bacteriol. 1993 Jun;175(11):3628-35 [8501066] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Validation of a brief screen for Post-Traumatic Stress Disorder with substance use disorder patients. AN - 68969430; 16574331 AB - To evaluate a 4-item screen for Post-Traumatic Stress Disorder (PTSD) for use with patients diagnosed with substance use disorders, 97 patients were recruited from substance use disorder treatment clinics at a large medical center. Participants completed the self-administered 4-item PTSD screen. Psychologists interviewed patients using the Clinician Administered PTSD Scale (CAPS). Sensitivity and specificity were calculated using the CAPS as the criterion for PTSD. Results were compared to chart diagnoses. The prevalence of PTSD was 33%. The screen identified 91% of PTSD cases, where only 25% of PTSD cases were diagnosed in the medical chart. The screen demonstrated good test-retest reliability (r=.80) and yielded a sensitivity of .91 and specificity of .80 using a cut score of 3. Likelihood ratios indicate that the screen has good ability to detect PTSD in this population, and that patients with positive screens that do not meet criteria for PTSD are likely to report significant subthreshold symptoms. Screening for PTSD in SUD treatment settings is time efficient and may increase the detection of previously unrecognized PTSD. JF - Addictive behaviors AU - Kimerling, Rachel AU - Trafton, Jodie A AU - Nguyen, Brian AD - National Center for PTSD, VA Palo Alto Health Care System, 795 Willow Road PTSD-334, Menlo Park, CA 94025, USA. Rachel.Kimerling@med.va.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 2074 EP - 2079 VL - 31 IS - 11 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Sensitivity and Specificity KW - Reproducibility of Results KW - Humans KW - Aged KW - Primary Health Care -- methods KW - Likelihood Functions KW - Psychometrics KW - Psychiatric Status Rating Scales KW - Signal Detection, Psychological KW - Adult KW - Middle Aged KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Male KW - Stress Disorders, Post-Traumatic -- psychology KW - Stress Disorders, Post-Traumatic -- complications KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68969430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Validation+of+a+brief+screen+for+Post-Traumatic+Stress+Disorder+with+substance+use+disorder+patients.&rft.au=Kimerling%2C+Rachel%3BTrafton%2C+Jodie+A%3BNguyen%2C+Brian&rft.aulast=Kimerling&rft.aufirst=Rachel&rft.date=2006-11-01&rft.volume=31&rft.issue=11&rft.spage=2074&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-03 N1 - Date created - 2006-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam. AN - 68969145; 17006952 AB - U.S. Army Chemical Corps veterans handled and sprayed herbicides in Vietnam resulting in exposure to Agent Orange and its contaminant 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin). This study examined the long-term health effects associated with herbicide exposure among these Vietnam veterans. A health survey of these 1,499 Vietnam veterans and a group of 1,428 non-Vietnam veterans assigned to chemical operations jobs was conducted using a computer-assisted telephone interview (CATI) system. Exposure to herbicides was assessed by analyzing serum specimens from a sample of 897 veterans for dioxin. Logistic regression analyses were used to estimate the risk of selected medical outcomes associated with herbicide exposure. Odds ratios for diabetes, heart disease, hypertension, and chronic respiratory disease were elevated, but not significantly (P>0.05) for those who served in Vietnam. However, they were significantly elevated among those Vietnam veterans who sprayed herbicides: diabetes, odds ratio (OR)=1.50 (95% confidence interval [95%CI]=1.15-1.95); heart disease, OR=1.52 (1.18-1.94); hypertension, OR=1.32 (1.08-1.61); and chronic respiratory condition, OR=1.62 (1.28-2.05). Hepatitis was associated with Vietnam service, but not with herbicide application. Vietnam veterans who were occupationally exposed to herbicide experienced a higher risk of several chronic medical conditions relative to other non-Vietnam veterans. A potential selection bias is of concern. However, there were relatively high participation rates in both the Vietnam and non-Vietnam veteran groups, and the prevalence rates of some of these medical conditions among non-Vietnam veterans were comparable to general populations. Therefore, self-selection factors are considered unlikely to have biased the study results. JF - American journal of industrial medicine AU - Kang, Han K AU - Dalager, Nancy A AU - Needham, Larry L AU - Patterson, Donald G AU - Lees, Peter S J AU - Yates, Katherine AU - Matanoski, Genevieve M AD - Veterans Health Administration, Department of Veterans Affairs, Washington, District of Columbia 20420, USA. han.kang@va.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 875 EP - 884 VL - 49 IS - 11 SN - 0271-3586, 0271-3586 KW - Defoliants, Chemical KW - 0 KW - Environmental Pollutants KW - Polychlorinated Dibenzodioxins KW - 2,4-Dichlorophenoxyacetic Acid KW - 2577AQ9262 KW - Agent Orange KW - 39277-47-9 KW - 2,4,5-Trichlorophenoxyacetic Acid KW - 9Q963S4YMX KW - Index Medicus KW - Heart Diseases -- epidemiology KW - Humans KW - Diabetes Mellitus -- epidemiology KW - Lung Diseases -- epidemiology KW - Logistic Models KW - Hypertension -- epidemiology KW - Health Surveys KW - Vietnam Conflict KW - Case-Control Studies KW - Interviews as Topic KW - Middle Aged KW - United States -- epidemiology KW - Environmental Pollutants -- blood KW - Environmental Pollutants -- adverse effects KW - Male KW - Veterans KW - Defoliants, Chemical -- adverse effects KW - 2,4-Dichlorophenoxyacetic Acid -- adverse effects KW - 2,4,5-Trichlorophenoxyacetic Acid -- adverse effects KW - Polychlorinated Dibenzodioxins -- adverse effects KW - Health Status KW - Occupational Exposure -- adverse effects KW - Polychlorinated Dibenzodioxins -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68969145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Health+status+of+Army+Chemical+Corps+Vietnam+veterans+who+sprayed+defoliant+in+Vietnam.&rft.au=Kang%2C+Han+K%3BDalager%2C+Nancy+A%3BNeedham%2C+Larry+L%3BPatterson%2C+Donald+G%3BLees%2C+Peter+S+J%3BYates%2C+Katherine%3BMatanoski%2C+Genevieve+M&rft.aulast=Kang&rft.aufirst=Han&rft.date=2006-11-01&rft.volume=49&rft.issue=11&rft.spage=875&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-09 N1 - Date created - 2006-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Complementary and alternative medicine approaches to pain management. AN - 68949537; 16937354 AB - This article argues for and illustrates incorporating complementary and alternative medicine (CAM) interventions into pain treatment plans. Two CAM treatments, cranial electrotherapy stimulation (CES) and self-hypnosis training, are offered in a multidisciplinary pain treatment program. Because these interventions focus on pain relief, they may be of particular interest to patients who have chronic pain who begin treatment with a primary interest in pain reduction. Two cases that illustrate the clinical application of CES and self-hypnosis are presented. When effective, these interventions can help patients have greater confidence in treatments offered by psychologists for pain management and may help make them more open to participating in other psychological interventions that have established efficacy for pain management (e.g., cognitive-behavioral therapy). Because of their brevity, these treatments also can be offered alone to patients who may not have the resources or time to participate in more time-intensive treatment. JF - Journal of clinical psychology AU - Tan, Gabriel AU - Alvarez, Julie A AU - Jensen, Mark P AD - Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA. TAN.GABRIEL@med.va.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1419 EP - 1431 VL - 62 IS - 11 SN - 0021-9762, 0021-9762 KW - Index Medicus KW - Humans KW - Headache -- therapy KW - Hypnosis -- methods KW - Cognitive Therapy KW - Military Personnel KW - Leg Injuries -- etiology KW - Treatment Outcome KW - Chronic Disease KW - Middle Aged KW - Headache -- etiology KW - Wounds, Gunshot -- complications KW - Accidents, Occupational KW - Male KW - Low Back Pain -- therapy KW - Spinal Osteophytosis -- therapy KW - Spinal Osteophytosis -- etiology KW - Complementary Therapies -- methods KW - Lumbar Vertebrae KW - Electric Stimulation Therapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68949537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Complementary+and+alternative+medicine+approaches+to+pain+management.&rft.au=Tan%2C+Gabriel%3BAlvarez%2C+Julie+A%3BJensen%2C+Mark+P&rft.aulast=Tan&rft.aufirst=Gabriel&rft.date=2006-11-01&rft.volume=62&rft.issue=11&rft.spage=1419&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-16 N1 - Date created - 2006-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reduced aerobic capacity and physical functioning in older HIV-infected men. AN - 68218711; 17147498 AB - Aerobic capacity and physical functioning decline with age and chronic illness. The extent of physical disability is unknown in older HIV-infected adults, who represent a rapidly growing proportion of HIV/AIDS patients in the United States. We performed functional performance testing including treadmill testing in 32 HIV-infected male veterans aged 40-69 years. Controls were 47 healthy male subjects tested previously in the same exercise laboratory. HIV-infected subjects were classified as younger (40-49 years, n = 12) or older age (50+ years, n = 20). Peak aerobic capacity (VO2peak) was significantly reduced in the older vs. younger HIV subjects [19.1 mL/kg/min +/- 5.7 (mean, SD) vs. 25.2 +/- 4.2, p = 0.01]. VO2peak was reduced 41% +/- 15% (mean, SD) in HIV-infected subjects compared to expected values from age-matched healthy controls. Regression analyses show a similar decline in VO2peak with age in HIV-infected and healthy controls. Mean 6-min walk distance was not significantly different between the HIV-infected age groups, and was reduced only 8% compared to expected values for healthy adults. Current CD4 count and HAART exposure were similar in the two age groups and were not significantly associated with VO2peak. Anemia (HCT <35%) was significantly associated with reduced VO2peak (p = 0.02), but this association was not independent of the effect of age (p = 0.1). We conclude that older HIV-infected adults have markedly impaired aerobic capacity but maintain the capacity to undertake day-to-day activities. Additional physiologic and metabolic testing is needed to measure the effect of HAART toxicity and primary aging on aerobic capacity, and to determine if older HIV-infected adults are at greater risk. JF - AIDS research and human retroviruses AU - Oursler, K K AU - Sorkin, J D AU - Smith, B A AU - Katzel, L I AD - University of Maryland School of Medicine, and the Baltimore Veterans Administration Medical Center, Geriatric Research, Education and Clinical Center, Baltimore, Maryland 21201, USA. Oursler@umbi.umd.edu Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1113 EP - 1121 VL - 22 IS - 11 SN - 0889-2229, 0889-2229 KW - Index Medicus KW - AIDS/HIV KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Physical Fitness -- physiology KW - Male KW - Aging -- physiology KW - HIV Infections KW - Exercise -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68218711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+research+and+human+retroviruses&rft.atitle=Reduced+aerobic+capacity+and+physical+functioning+in+older+HIV-infected+men.&rft.au=Oursler%2C+K+K%3BSorkin%2C+J+D%3BSmith%2C+B+A%3BKatzel%2C+L+I&rft.aulast=Oursler&rft.aufirst=K&rft.date=2006-11-01&rft.volume=22&rft.issue=11&rft.spage=1113&rft.isbn=&rft.btitle=&rft.title=AIDS+research+and+human+retroviruses&rft.issn=08892229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-10 N1 - Date created - 2006-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Administration of pegylated interferon-alpha-2a or -2b does not induce sickness behavior in Lewis rats. AN - 68195938; 17049181 AB - Repeated administration of interferon-alpha (IFN-alpha) or pegylated IFN-alpha to patients with chronic hepatitis C viral infection induces a flu-like syndrome as well as neuropsychiatric side effects, which are well recognized, but poorly understood. Although pegylation appears to have improved viral response rates in patients with hepatitis C, there are still neurotoxicities associated with pegylated IFN-alpha therapy, in particular, depression, which can compromise and sometime prevent successful completion of antiviral treatment. This study assessed the effects of two forms of pegylated IFN-alpha [peginterferon-alfa-2a (PEG-2a) and peginterferon-alfa-2b (PEG-2b)] in rats in order to develop an animal model of IFN-induced "depression" (often described as sickness behavior) that can be used to more comprehensively investigate the neurochemical mechanisms of IFN-induced depression. Sixty male and female Lewis rats were randomly assigned to one of six treatment groups: (1) saline (SAL)+SAL (2) SAL+PEG-2a; (3) SAL+PEG-2b; (4) selective serotonin reuptake inhibitor (SSRI)+SAL, (5) SSRI+PEG-2a; (6) SSRI+PEG-2b. Rats were pretreated with intraperitoneal (i.p.) saline (0.9%) or 7.5mg/kg/day fluoxetine for 1 week, followed by 3 weeks of concurrent i.p. administration of 650 microg/wk of PEG-2a or PEG-2b. Using locomotor activity, the forced swim test, and weight gain as behavioral measures of sickness behavior, our data showed that Lewis rats did not develop an IFN-induced "depressive syndrome." Western blot analyses of brain and liver tissue indicated that signal transducer and activator of transcripton (STAT1) was not phosphorylated following IFN-alpha administration, suggesting that the pegylated compounds may not have bound type I IFN receptors in the rat. Collectively, our data suggest that Lewis rats are likely not a useful model to study IFN-induced depression. JF - Psychoneuroendocrinology AU - Loftis, Jennifer M AU - Wall, Jennifer M AU - Pagel, Rebecca L AU - Hauser, Peter AD - Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, 3710 SW US Veteran's Hospital Road, Portland, OR 97239, USA. Jennifer.loftis2@med.va.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1289 EP - 1294 VL - 31 IS - 10 SN - 0306-4530, 0306-4530 KW - Antidepressive Agents KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - STAT1 Transcription Factor KW - Stat1 protein, rat KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2b KW - 43K1W2T1M6 KW - interferon alfa-2a KW - 47RRR83SK7 KW - peginterferon alfa-2b KW - G8RGG88B68 KW - peginterferon alfa-2a KW - Q46947FE7K KW - Index Medicus KW - Animals KW - Swimming KW - Rats, Inbred Lew KW - Antidepressive Agents -- pharmacology KW - Liver -- metabolism KW - Brain -- metabolism KW - Rats KW - Behavior, Animal -- drug effects KW - Body Weight -- drug effects KW - Motor Activity -- drug effects KW - STAT1 Transcription Factor -- metabolism KW - Female KW - Male KW - Interferon-alpha -- pharmacology KW - Depressive Disorder -- chemically induced KW - Disease Models, Animal KW - Polyethylene Glycols -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68195938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychoneuroendocrinology&rft.atitle=Administration+of+pegylated+interferon-alpha-2a+or+-2b+does+not+induce+sickness+behavior+in+Lewis+rats.&rft.au=Loftis%2C+Jennifer+M%3BWall%2C+Jennifer+M%3BPagel%2C+Rebecca+L%3BHauser%2C+Peter&rft.aulast=Loftis&rft.aufirst=Jennifer&rft.date=2006-11-01&rft.volume=31&rft.issue=10&rft.spage=1289&rft.isbn=&rft.btitle=&rft.title=Psychoneuroendocrinology&rft.issn=03064530&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-19 N1 - Date created - 2006-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enhanced cortisol suppression to dexamethasone associated with Gulf War deployment. AN - 68192057; 17049422 AB - To examine whether PTSD or post-deployment health symptoms in veterans of the first Gulf War (Operation Desert Shield/Storm) are associated with enhanced suppression of the pituitary-adrenal axis to low-dose dexamethasone (DEX). Plasma cortisol and lymphocyte glucocorticoid receptor (GR) number were measured at 08:00 h on two consecutive days, before and after administration of 0.5mg of DEX at 23:00 h in 42 male Gulf War veterans (14 without psychiatric illness, 16 with PTSD only, and 12 with both PTSD and MDD) and 12 healthy male veterans not deployed to the Gulf War or another war zone. In the absence of group differences in basal cortisol levels or GR number, Gulf War veterans without psychiatric illness and Gulf War veterans with PTSD only had significantly greater cortisol suppression to DEX than non-deployed veterans and Gulf War veterans with both PTSD and MDD. Gulf War deployment was associated with significantly greater cortisol suppression to DEX controlling for weight, smoking status, PTSD, and MDD; PTSD was not associated with response to DEX. Among Gulf War veterans musculoskeletal symptoms were significantly associated with cortisol suppression and those who reported taking anti-nerve gas pills (i.e., pyridostigmine bromide) during the war had significantly greater DEX-induced cortisol suppression than those who did not. The data demonstrate that alterations in neuroendocrine function are associated with deployment to the Gulf War and post-deployment musculoskeletal symptoms, but not PTSD. Additional studies are needed to examine the relationship of enhanced glucocorticoid responsivity to deployment exposures and chronic unexplained medical symptoms in Gulf War veterans. JF - Psychoneuroendocrinology AU - Golier, Julia A AU - Schmeidler, James AU - Legge, Juliana AU - Yehuda, Rachel AD - Department of Psychiatry, James J Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA. julia.gotier@med.va.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1181 EP - 1189 VL - 31 IS - 10 SN - 0306-4530, 0306-4530 KW - Receptors, Glucocorticoid KW - 0 KW - Dexamethasone KW - 7S5I7G3JQL KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Lymphocytes -- chemistry KW - Environmental Exposure -- statistics & numerical data KW - Humans KW - Adult KW - Receptors, Glucocorticoid -- analysis KW - Middle Aged KW - Male KW - Veterans KW - Gulf War KW - Dexamethasone -- pharmacology KW - Hydrocortisone -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68192057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychoneuroendocrinology&rft.atitle=Enhanced+cortisol+suppression+to+dexamethasone+associated+with+Gulf+War+deployment.&rft.au=Golier%2C+Julia+A%3BSchmeidler%2C+James%3BLegge%2C+Juliana%3BYehuda%2C+Rachel&rft.aulast=Golier&rft.aufirst=Julia&rft.date=2006-11-01&rft.volume=31&rft.issue=10&rft.spage=1181&rft.isbn=&rft.btitle=&rft.title=Psychoneuroendocrinology&rft.issn=03064530&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-19 N1 - Date created - 2006-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Update on evidence-based practices for safe patient handling and movement. AN - 68191375; 17130759 JF - Orthopedic nursing AU - Nelson, Audrey AU - Baptiste, Andrea S AD - Nursing Service for Research, James A. Haley Veterans Hospital, Tampa, Florida, USA. audrey.nelson@med.va.gov PY - 2006 SP - 367 EP - 368 VL - 25 IS - 6 SN - 0744-6020, 0744-6020 KW - Nursing KW - Humans KW - Curriculum KW - Task Performance and Analysis KW - Transportation of Patients -- methods KW - Lifting -- adverse effects KW - Risk Assessment KW - Nursing Staff KW - Occupational Health KW - Musculoskeletal Diseases -- etiology KW - Evidence-Based Medicine -- education KW - Musculoskeletal Diseases -- prevention & control KW - Human Engineering -- methods KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- etiology KW - Evidence-Based Medicine -- organization & administration KW - Safety Management -- organization & administration KW - Human Engineering -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68191375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Orthopedic+nursing&rft.atitle=Update+on+evidence-based+practices+for+safe+patient+handling+and+movement.&rft.au=Nelson%2C+Audrey%3BBaptiste%2C+Andrea+S&rft.aulast=Nelson&rft.aufirst=Audrey&rft.date=2006-11-01&rft.volume=25&rft.issue=6&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Orthopedic+nursing&rft.issn=07446020&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-23 N1 - Date created - 2006-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rhinitis medicamentosa and the stuffy nose. AN - 68123355; 17088123 JF - The Journal of allergy and clinical immunology AU - Lockey, Richard F AD - Department of Internal Medicine, Division of Allergy and Immunology, University of South Florida College of Medicine, and the James A. Haley Veterans' Administration Hospital, Tampa, FL 33612, USA. rlockey@hsc.usf.edu Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1017 EP - 1018 VL - 118 IS - 5 SN - 0091-6749, 0091-6749 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Chronic Disease KW - Rhinitis -- chemically induced KW - Nasal Obstruction -- etiology KW - Nasal Obstruction -- chemically induced KW - Rhinitis -- etiology KW - Nasal Obstruction -- diagnosis KW - Rhinitis -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68123355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Rhinitis+medicamentosa+and+the+stuffy+nose.&rft.au=Lockey%2C+Richard+F&rft.aulast=Lockey&rft.aufirst=Richard&rft.date=2006-11-01&rft.volume=118&rft.issue=5&rft.spage=1017&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-15 N1 - Date created - 2006-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The neuropathology, medical management and dental implications of autism. AN - 68107387; 17082277 AB - A paucity of information exists in the dental literature about autism and its dental implications. The authors conducted a MEDLINE search for the period 2000 through 2006, using the term "autism," with the aim of defining the condition's clinical manifestations, dental and medical treatment and dental implications. Autism is a severe developmental brain disorder that appears in infancy, persists throughout life, and is characterized by impaired social interaction, abnormalities in communication (both verbal and nonverbal) and restricted interests. Often accompanying the disorder are behavioral disturbances - such as self-mutilation, aggression, psychiatric symptoms and seizures - that necessitate the administration of multiple medications to help the affected person participate effectively in the educational and rehabilitative process. Dentists caring for people with autism must be familiar with the manifestations of the disease and its associated features so that they can garner the maximum level of patient cooperation. They also must be familiar with the medications used to treat the associated features of the disorder because many of them cause untoward orofacial and systemic reactions and may precipitate adverse interactions with dental therapeutic agents. JF - Journal of the American Dental Association (1939) AU - Friedlander, Arthur H AU - Yagiela, John A AU - Paterno, Victoria I AU - Mahler, Michael E AD - VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA. arthur.friedlander@med.va.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1517 EP - 1527 VL - 137 IS - 11 SN - 0002-8177, 0002-8177 KW - Dentistry KW - Index Medicus KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Child KW - Dental Care for Children -- methods KW - Autistic Disorder -- etiology KW - Autistic Disorder -- drug therapy KW - Dental Care for Disabled -- methods KW - Autistic Disorder -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68107387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=The+neuropathology%2C+medical+management+and+dental+implications+of+autism.&rft.au=Friedlander%2C+Arthur+H%3BYagiela%2C+John+A%3BPaterno%2C+Victoria+I%3BMahler%2C+Michael+E&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2006-11-01&rft.volume=137&rft.issue=11&rft.spage=1517&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-16 N1 - Date created - 2006-11-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Dent Assoc. 2007 Mar;138(3):288; author reply 288, 290, 292 [17332031] J Am Dent Assoc. 2007 Mar;138(3):286-8; author reply 288, 290, 292 [17332028] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Public Mental Health Care Utilization by Older Adults AN - 57214926; 200713382 AB - The present study examined the extent to which older adults began public mental health treatment throughout Texas in 1999, the types of services they used, & how they compared on demographic & clinical variables to younger consumers. Notwithstanding recent policy & related developments, older adults were found to use public mental health services at substantially low rates, as in past decades. Significantly, older consumers tended to be relatively healthy & independent. Among younger &, even more so, older consumers, there were relatively high proportions of rural residents & minorities, groups previously found to be unlikely to utilize private mental health services. Overall, the findings urge that greater attention be devoted to public mental health outreach & service delivery with the elderly, & raise the question of what role the public mental health system should have in nursing homes & other long-term care settings. References. Adapted from the source document. JF - Administration and Policy in Mental Health AU - Karlin, Bradley E AU - Norris, Margaret P AD - VA Palo Alto Health Care System, Dept Psychology, Texas A&M U bradley.karlin@med.va.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 730 EP - 736 PB - Springer, Dordrecht The Netherlands VL - 33 IS - 6 SN - 0894-587X, 0894-587X KW - elderly KW - public mental health KW - service utilization KW - Users KW - Elderly people KW - Variables KW - Mental health services KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57214926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health&rft.atitle=Public+Mental+Health+Care+Utilization+by+Older+Adults&rft.au=Karlin%2C+Bradley+E%3BNorris%2C+Margaret+P&rft.aulast=Karlin&rft.aufirst=Bradley&rft.date=2006-11-01&rft.volume=33&rft.issue=6&rft.spage=730&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-005-0003-5 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-31 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Elderly people; Public health; Mental health services; Users; Variables DO - http://dx.doi.org/10.1007/s10488-005-0003-5 ER - TY - JOUR T1 - The Treatment of Depression in Older Adults in the Primary Care Setting: An Evidence-Based Review AN - 57104655; 200704406 AB - The objective of this study was to conduct an evidence-based review of treatments for depression in older adults in the primary care setting. A literature search was conducted using PsycINFO & Medline to identify relevant, English language studies published from January 1994 to April 2004 with samples aged 55 & older. Studies were required to be randomized controlled trials that compared psychosocial interventions conducted within the primary care setting with "usual care" conditions. Eight studies with older adult samples met inclusion criteria & were included in the review. Two treatment models were evident: Geriatric Evaluation Management (GEM) clinics & an approach labeled integrated health care models. Support was found for each model, with improvement in depressive symptoms & better outcomes than usual care; however, findings varied by depression severity, & interventions were difficult to compare. Further efforts to improve research & clinical care of depression in the primary care setting for older adults are needed. The authors recommend the use of interdisciplinary teams & more implementation of psychosocial treatments shown to be effective for older adults. Tables, References. [Copyright 2006 The American Psychological Association.] JF - Health Psychology AU - Skultety, Karyn M AU - Zeiss, Antonette AD - Veterans Affairs Palo Alto Health Care System, Menlo Park, CA karyn.skultety@med.va.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 665 EP - 674 PB - American Psychological Association, Washington DC VL - 25 IS - 6 SN - 0278-6133, 0278-6133 KW - depression, older adults, primary care, medical setting, review KW - Depression KW - Older people KW - Primary health care KW - Psychosocial intervention KW - Treatment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57104655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Psychology&rft.atitle=The+Treatment+of+Depression+in+Older+Adults+in+the+Primary+Care+Setting%3A+An+Evidence-Based+Review&rft.au=Skultety%2C+Karyn+M%3BZeiss%2C+Antonette&rft.aulast=Skultety&rft.aufirst=Karyn&rft.date=2006-11-01&rft.volume=25&rft.issue=6&rft.spage=665&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2F0278-6133.25.6.665 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Older people; Depression; Primary health care; Psychosocial intervention; Treatment DO - http://dx.doi.org/10.1037/0278-6133.25.6.665 ER - TY - JOUR T1 - Metastic Acetabular Fractures: Evaluation and Approach to Management AN - 57093927; 200704400 AB - Although bone metastasis to the acetabulum can cause significant disability from pain & immobility, little has been written about the diagnosis & management of a pathologic acetabular fracture. We present three patients with metastatic acetabular fractures & discuss an approach to evaluation & management. When a high index of suspicion of fracture exists, further radiographic workup is warranted. Management requires a multidisciplinary approach. Factors such as age, associated comorbidities, natural history of the underlying primary cancer, general health status, prognosis, acetabular fracture characteristics, & quality of bone should be considered. We briefly discuss the options available to nonoperative candidates. Figures, References. [Copyright 2006 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc.] JF - Journal of Pain and Symptom Management AU - Singh, Priya C AU - Patel, Dipak V AU - Chang, Victor T AD - c/o Chang -- VA New Jersey Health Care System, East Orange, NJ Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 502 EP - 507 PB - Elsevier, New York NY VL - 32 IS - 5 SN - 0885-3924, 0885-3924 KW - Metastases, cancer, acetabulum, palliative care, esophageal cancer, prostate cancer, rectal pain KW - Bones KW - Fractures KW - Palliative Care KW - Pain KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57093927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pain+and+Symptom+Management&rft.atitle=Metastic+Acetabular+Fractures%3A+Evaluation+and+Approach+to+Management&rft.au=Singh%2C+Priya+C%3BPatel%2C+Dipak+V%3BChang%2C+Victor+T&rft.aulast=Singh&rft.aufirst=Priya&rft.date=2006-11-01&rft.volume=32&rft.issue=5&rft.spage=502&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pain+and+Symptom+Management&rft.issn=08853924&rft_id=info:doi/10.1016%2Fj.jpainsymman.2006.05.008 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - CODEN - JSPME2 N1 - SubjectsTermNotLitGenreText - Cancer; Pain; Palliative Care; Fractures; Bones DO - http://dx.doi.org/10.1016/j.jpainsymman.2006.05.008 ER - TY - JOUR T1 - Skin infections with methicillin-resistant Staphylococcus aureus presenting as insect or spider bites AN - 20721343; 7119488 JF - American Journal of Health-System Pharmacy AU - Segarra-Newnham, Marisel AD - Veterans Affairs Medical Center , 7305 North Military Trail , West Palm Beach, FL 33410-6400, marisel.segarra-newnham@med.va.gov Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 2046 EP - 2048 PB - American Society of Health-System Pharmacists, 7272 Wisconsin Ave. Bethesda MD 20814 USA, [URL:http://www.ashp.org] VL - 63 IS - 21 SN - 1079-2082, 1079-2082 KW - Microbiology Abstracts B: Bacteriology KW - Skin KW - Bites KW - Drug resistance KW - Araneae KW - Staphylococcus aureus KW - Infection KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20721343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health-System+Pharmacy&rft.atitle=Skin+infections+with+methicillin-resistant+Staphylococcus+aureus+presenting+as+insect+or+spider+bites&rft.au=Segarra-Newnham%2C+Marisel&rft.aulast=Segarra-Newnham&rft.aufirst=Marisel&rft.date=2006-11-01&rft.volume=63&rft.issue=21&rft.spage=2046&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health-System+Pharmacy&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Skin; Bites; Drug resistance; Infection; Araneae; Staphylococcus aureus ER - TY - JOUR T1 - Porcine Endothelial Cells and Iliac Arteries Transduced with AdenoIL-4 Are Intrinsically Protected, through Akt Activation, against Immediate Injury Caused by Human Complement AN - 20232054; 7166905 AB - Vascular endothelial cells (ECs) can be injured in a variety of pathologic processes that involve activated complement. We reported previously that porcine ECs incubated with exogenous IL-4 or IL-13 are protected from cytotoxicity by human complement and also from apoptosis by TNF- alpha . The resistance to complement consists of an intrinsic mechanism that is lost a few days after cytokine removal. In our current study, we investigated whether transfer of the IL-4 gene into porcine ECs in vitro and into porcine vascular tissues in vivo would induce efficient and durable protection from human complement. We found that ECs transduced with adenoIL-4 or adenoIL-13 exhibited continuous production of the cytokine and prolonged protection from complement-mediated killing. IL-4 also protected ECs from activation: ECs incubated with IL-4 did not develop cell retraction and intercellular gaps upon stimulation with sublytic complement. The endothelium and subendothelium of pig iliac arteries that were transduced with the IL-4 gene were effectively protected from complement-dependent immediate injury after perfusion with human blood. However, after similar perfusion, the endothelium was immediately lost from arteries that were transduced with a control adenovirus. The protection was not due to up-regulation of the complement regulators decay accelerating factor, membrane cofactor protein, and CD59, or to reduced complement activation, but required the participation of Akt. Although our studies model protection in pig-to-primate xenotransplantation, our findings of IL-4 induction of Akt-mediated protection may be more broadly applicable to EC injury as manifested in ischemia-reperfusion, allotransplantation, and various vascular diseases. JF - Journal of Immunology AU - Black, Sylvester M AU - Grehan, John F AU - Rivard, Andrew L AU - Benson, Barbara A AU - Wahner, Andrea E AU - Koch, Alisa E AU - Levay-Young, Brett K AU - Dalmasso, Agustin P AD - Department of Surgery and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455. Veterans Administration and Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 7355 EP - 7363 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 10 SN - 0022-1767, 0022-1767 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Interleukin 4 KW - Perfusion KW - Apoptosis KW - Transplantation KW - Injuries KW - CD59 antigen KW - Arteries KW - Complement KW - Adenovirus KW - Animal models KW - Vascular diseases KW - Endothelial cells KW - Blood KW - Interleukin 13 KW - Cytotoxicity KW - Endothelium KW - Complement activation KW - AKT protein KW - decay-accelerating factor KW - Tumor necrosis factor- alpha KW - Xenografts KW - membrane cofactor protein KW - Vascular system KW - V 22350:Immunology KW - W 30945:Fermentation & Cell Culture KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20232054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Porcine+Endothelial+Cells+and+Iliac+Arteries+Transduced+with+AdenoIL-4+Are+Intrinsically+Protected%2C+through+Akt+Activation%2C+against+Immediate+Injury+Caused+by+Human+Complement&rft.au=Black%2C+Sylvester+M%3BGrehan%2C+John+F%3BRivard%2C+Andrew+L%3BBenson%2C+Barbara+A%3BWahner%2C+Andrea+E%3BKoch%2C+Alisa+E%3BLevay-Young%2C+Brett+K%3BDalmasso%2C+Agustin+P&rft.aulast=Black&rft.aufirst=Sylvester&rft.date=2006-11-01&rft.volume=177&rft.issue=10&rft.spage=7355&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Interleukin 4; Transplantation; Apoptosis; Perfusion; CD59 antigen; Injuries; Arteries; Complement; Animal models; Vascular diseases; Endothelial cells; Blood; Cytotoxicity; Interleukin 13; Complement activation; Endothelium; AKT protein; decay-accelerating factor; Xenografts; Tumor necrosis factor- alpha; membrane cofactor protein; Vascular system; Adenovirus ER - TY - JOUR T1 - Differentiation of Embryonic Stem Cells Conditionally Expressing Neurogenin 3 AN - 19790376; 7126884 AB - Expression of the proendocrine gene neurogenin 3 (Ngn3) is required for the development of pancreatic islets. To better characterize the molecular events regulated by Ngn3 during development, we have determined the expression profiles of murine embryonic stem cells (mESCs) uniformly induced to overexpress Ngn3. An mESC line was created in order to induce Ngn3 by adding doxycycline to the culture medium. Genome-wide microarray analysis was performed to identify genes regulated by Ngn3 in a variety of contexts, including undifferentiated ESCs and differentiating embryoid bodies (EBs). Genes regulated by Ngn3 in a context-independent manner were identified and analyzed using systematic gene ontology tools. This analysis revealed Notch signaling as the most significantly regulated signaling pathway (p = .009). This result is consistent with the hypothesis that Ngn3 expression makes the cell competent for Notch signaling to be activated and, conversely, more sensitive to Notch signaling inhibition. Indeed, EBs induced to express Ngn3 were significantly more sensitive to gamma -secretase inhibitor-mediated Notch signaling inhibition (p < .0001) when compared with uninduced EBs. Moreover, we find that Ngn3 induction in differentiating ESCs results in significant increases in insulin, glucagon, and somatostatin expression. JF - Stem Cells AU - Treff, Nathan R AU - Vincent, Robert K AU - Budde, Melisa L AU - Browning, Victoria L AU - Magliocca, Joseph F AU - Kapur, Vivek AU - Odorico, Jon S AD - University of Wisconsin-Madison School of Medicine and Public Health, Department of Surgery, Madison, Wisconsin, USA. William S. Middleton Memorial Veterans Administration Hospital, Madison, Wisconsin, USA. University of Minnesota, Departments of Veterinary and Biomedical Sciences and Microbiology, St. Paul, Minnesota, USA. WiCell Research Institute, Madison, Wisconsin, USA Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 2529 EP - 2537 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 11 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - neurogenin 3 KW - Pancreas KW - Glucagon KW - Cell culture KW - Islets of Langerhans KW - Insulin KW - Somatostatin KW - Notch protein KW - Differentiation KW - Stem cells KW - Embryo cells KW - Secretase KW - Doxycycline KW - Signal transduction KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19790376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Differentiation+of+Embryonic+Stem+Cells+Conditionally+Expressing+Neurogenin+3&rft.au=Treff%2C+Nathan+R%3BVincent%2C+Robert+K%3BBudde%2C+Melisa+L%3BBrowning%2C+Victoria+L%3BMagliocca%2C+Joseph+F%3BKapur%2C+Vivek%3BOdorico%2C+Jon+S&rft.aulast=Treff&rft.aufirst=Nathan&rft.date=2006-11-01&rft.volume=24&rft.issue=11&rft.spage=2529&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - neurogenin 3; Glucagon; Pancreas; Islets of Langerhans; Cell culture; Somatostatin; Insulin; Notch protein; Differentiation; Stem cells; Embryo cells; Secretase; Doxycycline; Signal transduction ER - TY - RPRT T1 - FORT ROSECRANS NATIONAL CEMETERY ANNEX AT MCAS MIRAMAR, COUNTY OF SAN DIEGO, CALIFORNIA. AN - 36342085; 12304 AB - PURPOSE: The implementation of a land use agreement between the U.S. Department of the Navy and the U.S. Department of Veterans Affairs (VA) is proposed to provide for the construction and operation of an annex to the existing Fort Rosecrans National Cemetery at Point Loma in San Diego, California. The annex would be located at Marine Corps Air Station (MCAS) Miramar in San Diego. To fulfill its mission to provide funeral services and cemetery accommodations to veterans, the National Cemetery Administration (NCA) of the VA to provide cemetery services to veterans and other eligible persons. Since 1973, the interment rate in VA national cemeteries has increased by more than 15 percent, from 36,400 in 1973 to more than 93,000 in 2004. Interments are expected to continue increasing until 2008. The upward trend in veteran deaths results in a corresponding increase in the demand for interments in national cemeteries. Experience and recent historical data have shown that over 80 percent of persons interred in national cemeteries resided within 75 miles of the cemetery at the time of death. Therefore, NCA considers reasonable access to burial benefits to mean that a first interment option, for casketed or cremated remains in a national or state veterans' cemetery, is available within 75 miles of the veteran's place of residence. There are two other national cemeteries in southern California, namely, Los Angeles National Cemetery, located in western Los Angeles approximately 130 miles from San Diego, and Riverside National Cemetery, located adjacent to March Air Force Reserve Base approximately 90 miles from San Diego. The VA operates Fort Rosecrans National Cemetery, a 77-acre site located on a federal land withdrawal held by the Navy for military purposes in the center of the Point Loma peninsula. The National Cemetery Act of 1973 transferred administration of this tract to the VA. It is the only national cemetery in San Diego County and has been closed to first interment casketed burials since 1966. Approximately seven acres of additional land were acquired from Naval Base Point Loma in 2002. The NCA recently completed the construction of columbarium niches to provide for cremation burial options to San Diego veterans. With the availability of these niches as a burial option, the demand has been high. The NCA has therefore recognized the need for additional burial space for the 253,000 San Diego area military veterans, 23 percent of whom are expected to require interment over the next 20 years, that figure rising to 35 percent by 2035. At this rate, the columbarium niches are being rapidly depleted as the only first interment burial option available at this cemetery; the existing niches will provide adequate space until 2008. No addition land is available for expansion at Fort Rosecrans or Naval Base Point Loma. Under the proposed land use agreement at hand, the Department of the Navy has identified four potential sites at MCAS Miramar for the construction and operation of an annex to the Fort Rosecrans National Cemetery. Under the preferred alternative, the annex would be located on a 323-acre tract lying east of Interstate 805 and Nobel Drive within MCAS Miramar. Approximately 214 acres within the site would be developed as the annex. The annex would be developed in phases over a minimum 40-year planning period to meet the identified need for a minimum of 50,000 casketed gravesites and 40,000 columbarium niches. The facility would include entrance and external access roads, an 870-square-foot public information center for visitors, two committal service shelters for away-from-gravesite interment services, administrative and maintenance complexes, and parking facilities. In addition to the preferred alternative, one site alternative and a No Action Alternative are considered in this drat EIS. POSITIVE IMPACTS: The annex would help achieve the mission of the NCA to honor veterans with a final resting place and lasting memorials the commensurate their service to the nation. NEGATIVE IMPACTS: Development of the preferred site could negatively affect five archaeological sites, two of which have been declared eligible for inclusion in the National Register of Historic Places, while the other three are currently being evaluated for availability. In addition, the annex would displace 12.07 acres of recently occupied coastal California gnatcatcher habitat and 200.63 acres of potential, though unoccupied, gnatcatcher habitat, 29 basins providing habitat for other federally protected species; compensation habitat would be provided in both cases. Operation of the cemetery would result in gatherings of more than 25 persons per acre in an accident potential zone, a situation that would be incompatible with MCAS Miramar land use regulations. LEGAL MANDATES: National Cemetery Act of 1973 (83 Stat. 75) and National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). JF - EPA number: 060438, pages, October 20, 2006 PY - 2006 EP - ages, October 20 KW - Defense Programs KW - Archaeological Sites KW - Cemeteries KW - Coastal Zones KW - Endangered Species (Animals) KW - Parking KW - Roads KW - Safety KW - Traffic Analyses KW - Wetlands KW - Fort Rosecrans National Cemetery KW - California KW - Marine Corps Air Station Miramar KW - National Cemetery Act of 1973, Project Authorization KW - National Historic Preservation Act of 1966, Archaeological Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36342085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2006-10-20&rft.volume=&rft.issue=&rft.spage=ages&rft.isbn=&rft.btitle=FORT+ROSECRANS+NATIONAL+CEMETERY+ANNEX+AT+MCAS+MIRAMAR%2C+COUNTY+OF+SAN+DIEGO%2C+CALIFORNIA.&rft.title=FORT+ROSECRANS+NATIONAL+CEMETERY+ANNEX+AT+MCAS+MIRAMAR%2C+COUNTY+OF+SAN+DIEGO%2C+CALIFORNIA.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of the Navy, Naval Facilities Engineering Command, San Diego, California; NAVY N1 - Date revised - 2007-05-08 N1 - SuppNotes - Draft. Preparation date: October 20, 2006 N1 - Last updated - 2014-01-30 ER - TY - JOUR T1 - Use of alcoholic beverages in VA medical centers. AN - 68999006; 17052353 AB - Benzodiazepines are the first-line choice for the treatment of alcohol withdrawal syndrome. However, several hospitals continue to provide alcoholic beverages through their formulary for the treatment of alcohol withdrawal. While there are data on the prevalence of this practice in academic medical centers, there are no data on the availability of alcoholic beverages at the formularies of the hospitals operated by the department of Veteran's Affairs. In this study, we surveyed the Pharmacy managers at 112 Veterans' Affairs Medical Centers (VAMCs) to ascertain the availability of alcohol on the VAMC formularies, and presence or lack of a policy on the use of alcoholic beverages in their VA Medical Center. Of the pharmacy directors contacted, 81 responded. 8 did not allow their use, while 20 allowed their use. There was a lack of a consistent policy across the VA medical centers on availability and use of alcoholic beverages for the treatment of alcohol withdrawal syndrome. There is lack of uniform policy on the availability of alcoholic beverages across the VAMCs, which may create potential problems with difference in the standards of care. JF - Substance abuse treatment, prevention, and policy AU - Sattar, S Pirzada AU - Qadri, S Faiz AU - Warsi, Mustafa K AU - Okoye, Cordelia AU - Din, Amad U AU - Padala, Prasad R AU - Bhatia, Subhash C AD - Substance Use Disorders Program, Omaha VA Medical Center, 4101 Woolworth Ave, # 116A, Omaha, Nebraska 68105, USA. syed.sattar@med.va.gov Y1 - 2006/10/19/ PY - 2006 DA - 2006 Oct 19 SP - 30 VL - 1 KW - Central Nervous System Depressants KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - United States KW - Pharmacy Service, Hospital -- methods KW - Pharmacy Service, Hospital -- statistics & numerical data KW - Health Care Surveys KW - Syndrome KW - Humans KW - Drug Utilization KW - Central Nervous System Depressants -- therapeutic use KW - Ethanol -- therapeutic use KW - Alcohol Withdrawal Seizures -- therapy KW - Alcohol Withdrawal Delirium -- therapy KW - Hospitals, Veterans -- statistics & numerical data KW - Alcoholic Beverages -- utilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68999006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse+treatment%2C+prevention%2C+and+policy&rft.atitle=Use+of+alcoholic+beverages+in+VA+medical+centers.&rft.au=Sattar%2C+S+Pirzada%3BQadri%2C+S+Faiz%3BWarsi%2C+Mustafa+K%3BOkoye%2C+Cordelia%3BDin%2C+Amad+U%3BPadala%2C+Prasad+R%3BBhatia%2C+Subhash+C&rft.aulast=Sattar&rft.aufirst=S&rft.date=2006-10-19&rft.volume=1&rft.issue=&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Substance+abuse+treatment%2C+prevention%2C+and+policy&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-17 N1 - Date created - 2006-10-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Addict Dis. 2002;21(2):65-73 [11916373] JAMA. 2003 Feb 5;289(5):552 [12578486] N Engl J Med. 1976 Apr 1;294(14):757-62 [3733] Addict Behav. 1982;7(3):231-42 [7180617] J R Coll Physicians Lond. 1998 Jul-Aug;32(4):358-9 [9762632] South Med J. 1994 Jan;87(1):47-54 [8284718] Arch Gen Psychiatry. 1996 Aug;53(8):737-46 [8694687] JAMA. 1997 Jul 9;278(2):144-51 [9214531] J Subst Abuse Treat. 1998 Sep-Oct;15(5):437-42 [9751001] JAMA. 1989 Jan 20;261(3):403-7 [2909780] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Establishing a Translational Approach in the Nonhuman Primate for Targeting Cognitive Dysfunction Relevant to Schizophrenia T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40350794; 4419347 JF - 36th Annual Meeting of the Society for Neuroscience AU - Roberts, B M AU - Findlay, H A AU - Sandiego, C M AU - Williams, G V AU - Castner, S A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Primates KW - Schizophrenia KW - Translation KW - Mental disorders KW - Cognitive ability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40350794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Establishing+a+Translational+Approach+in+the+Nonhuman+Primate+for+Targeting+Cognitive+Dysfunction+Relevant+to+Schizophrenia&rft.au=Roberts%2C+B+M%3BFindlay%2C+H+A%3BSandiego%2C+C+M%3BWilliams%2C+G+V%3BCastner%2C+S+A&rft.aulast=Roberts&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparable Induction of Gamma Band Synchronization in the Prefrontal Cortex of Nonhuman Primates to that Found in Humans T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40350753; 4418417 JF - 36th Annual Meeting of the Society for Neuroscience AU - Klamer, D S AU - Roach, B J AU - Roberts, B M AU - Castner, S A AU - Ford, J M AU - Mathalon, D H AU - Williams, G V Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Primates KW - Synchronization KW - Cortex (prefrontal) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40350753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Comparable+Induction+of+Gamma+Band+Synchronization+in+the+Prefrontal+Cortex+of+Nonhuman+Primates+to+that+Found+in+Humans&rft.au=Klamer%2C+D+S%3BRoach%2C+B+J%3BRoberts%2C+B+M%3BCastner%2C+S+A%3BFord%2C+J+M%3BMathalon%2C+D+H%3BWilliams%2C+G+V&rft.aulast=Klamer&rft.aufirst=D&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunohistochemical Characterization of Corticotropin Releasing Factor Interaction with Brain Reward Pathways T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40336330; 4406762 JF - 36th Annual Meeting of the Society for Neuroscience AU - Tschetter, K E AU - Callahan, L B AU - Ronan, P J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Corticotropin-releasing hormone KW - Reinforcement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Immunohistochemical+Characterization+of+Corticotropin+Releasing+Factor+Interaction+with+Brain+Reward+Pathways&rft.au=Tschetter%2C+K+E%3BCallahan%2C+L+B%3BRonan%2C+P+J&rft.aulast=Tschetter&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Prospective evaluation of the use and outcome of admission stool guaiac testing: the Digital Rectal Examination on Admission to the Medical Service (DREAMS) Study. AN - 85402643; pmid-17016139 AB - Although physicians often perform fecal occult blood testing at the time of hospital admission, the practice of admission stool guaiac (ASG) testing has not been evaluated prospectively. The aim of this study was to determine the frequency and outcomes of digital rectal examination (DRE) and ASG testing in patients admitted to the hospital.We prospectively evaluated 2143 patients admitted to the medical service at our hospital over a 1-year period. A detailed clinical history was obtained, and the proportion of patients who had DRE and ASG testing, the frequency of positive tests, and the results of follow-up testing were determined.A DRE was performed in 1539 of the 2143 subjects (71.8%), and 1.8% had abnormal findings, 21.8% had a normal examination, and the result of ASG testing was the only documented finding in the remaining 76.4% of patients. ASG testing was performed in 1342 of the 2143 subjects (62.6%), and the ASG test was positive in 237 persons (17.7%). However, only 161 (67.9%) of those with a positive ASG test had further diagnostic testing and a colonic source of occult gastrointestinal blood loss was detected in 68 (42.2%) of these 161 persons.Although DRE and ASG testing are commonly performed on admission to the hospital, documentation of the findings and follow-up of positive tests are poor. These findings highlight the need to improve physician training on the appropriate use and documentation of the DRE and fecal occult blood testing. JF - Journal of clinical gastroenterology AU - Bini, Edmund J AU - Reinhold, Jean-Pierre AU - Weinshel, Elizabeth H AU - Generoso, Ramon AU - Salman, Loay AU - Dahr, Georges AU - Pena-Sing, Ivan AD - Department of Medicine, VA New York Harbor Healthcare System, New York, NY 10010, USA. Edmund.Bini@med.va.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 821 EP - 827 VL - 40 IS - 9 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - *Colorectal Neoplasms: diagnosis KW - *Diagnostic Tests, Routine: utilization KW - *Digital Rectal Examination: utilization KW - Female KW - *Guaiac: diagnostic use KW - Humans KW - *Indicators and Reagents KW - Logistic Models KW - Male KW - Middle Aged KW - *Occult Blood KW - *Patient Admission KW - Prospective Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85402643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Prospective+evaluation+of+the+use+and+outcome+of+admission+stool+guaiac+testing%3A+the+Digital+Rectal+Examination+on+Admission+to+the+Medical+Service+%28DREAMS%29+Study.&rft.au=Bini%2C+Edmund+J%3BReinhold%2C+Jean-Pierre%3BWeinshel%2C+Elizabeth+H%3BGeneroso%2C+Ramon%3BSalman%2C+Loay%3BDahr%2C+Georges%3BPena-Sing%2C+Ivan&rft.aulast=Bini&rft.aufirst=Edmund&rft.date=2006-10-01&rft.volume=40&rft.issue=9&rft.spage=821&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Methoxyflurane revisited: tale of an anesthetic from cradle to grave. AN - 68899375; 17006084 AB - Methoxyflurane metabolism and renal dysfunction: clinical correlation in man. By Richard I. Mazze, James R. Trudell, and Michael J. Cousins. Anesthesiology 1971; 35:247-52. Reprinted with permission. Serum inorganic fluoride concentration and urinary inorganic fluoride excretion were found to be markedly elevated in ten patients previously shown to have methoxyflurane induced renal dysfunction. Five patients with clinically evident renal dysfunction had a mean peak serum inorganic fluoride level (190 +/- 21 microm) significantly higher (P < 0.02) than that of those with abnormalities in laboratory tests only (106 +/- 17 microm). Similarly, patients with clinically evident renal dysfunction had a mean peak oxalic acid excretion (286 +/- 39 mg/24 h) significantly greater (P < 0.05) than that of those with laboratory abnormalities only (130 +/- 51 mg/24 h). That patients anesthetized with halothane had insignificant changes in serum inorganic fluoride concentration and oxalic acid excretion indicates that these substances are products of methoxyflurane metabolism. A proposed metabolic pathway to support this hypothesis is presented, as well as evidence to suggest that inorganic fluoride is the substance responsible for methoxyflurane renal dysfunction. JF - Anesthesiology AU - Mazze, Richard I AD - Stanford University School of Medicine, and Veterans Administration Palo Alto Health Care System, 300 Pasteur Drive, Stanford, CA 94305, USA. mazze@stanford.edu Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 843 EP - 846 VL - 105 IS - 4 SN - 0003-3022, 0003-3022 KW - Anesthetics, Inhalation KW - 0 KW - Methoxyflurane KW - 30905R8O7B KW - Oxalic Acid KW - 9E7R5L6H31 KW - Fluorides KW - Q80VPU408O KW - Abridged Index Medicus KW - Index Medicus KW - Mazze KW - Rats KW - Oxalic Acid -- metabolism KW - Animals KW - Fluorides -- metabolism KW - History, 20th Century KW - Humans KW - Kidney Diseases -- chemically induced KW - Anesthetics, Inhalation -- pharmacokinetics KW - Anesthetics, Inhalation -- adverse effects KW - Anesthetics, Inhalation -- history KW - Methoxyflurane -- adverse effects KW - Methoxyflurane -- pharmacokinetics KW - Methoxyflurane -- history KW - Anesthesiology -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68899375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=Methoxyflurane+revisited%3A+tale+of+an+anesthetic+from+cradle+to+grave.&rft.au=Mazze%2C+Richard+I&rft.aulast=Mazze&rft.aufirst=Richard&rft.date=2006-10-01&rft.volume=105&rft.issue=4&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=Anesthesiology&rft.issn=00033022&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-06 N1 - Date created - 2006-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Anesthesiology. 1971 Sep;35(3):247-52 [5095537] N1 - People - Mazze N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Mazze ER - TY - JOUR T1 - Human immunodeficiency virus-positive patient with bilateral corneal endothelial deposits. AN - 68895416; 17000409 AB - Ocular disorders associated with the human immunodeficiency virus are numerous as are ocular side effects from medications used to treat all of the manifestations of the virus. This report presents a unique case of bilateral, peripheral, and corneal endothelial deposits that may be a result of either the human immunodeficiency virus or the medication rifabutin. Rifabutin was the only medication prescribed that is known to cause endothelial deposits. Rifabutin is part of a multidrug therapy to prevent or treat Mycobacterium avium complex, a common pulmonary disease of immunocompromised individuals. A 69-year-old man with a 20-year history of being human immunodeficiency virus-positive presented with bilateral, asymptomatic, peripheral, and corneal endothelial deposits of unknown etiology. Literature research suggested that the deposits did not appear like cytomegalovirus retinitis-related deposits but rather a variant of rifabutin-associated deposits. These rifabutin-associated deposits differed from known rifabutin-associated deposits previously reported in the literature. These deposits have increased in pigmentation and density 5 years after the patient discontinued the drug. This case may represent another variation of rifabutin-associated endothelial deposits. Knowledge of human immunodeficiency virus and all the associated ocular findings (owing to both the condition and its treatment) is important, because the length of time patients are living with human immunodeficiency virus is increasing. JF - Optometry (St. Louis, Mo.) AU - Boyer, Stephen P AU - Gay, Dax A AD - Department of Veterans Affairs, Illiana Healthcare System, Danville, Illinois 61832, USA. Stephen.Boyer@med.va.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 494 EP - 498 VL - 77 IS - 10 SN - 1529-1839, 1529-1839 KW - Anti-Bacterial Agents KW - 0 KW - Rifabutin KW - 1W306TDA6S KW - Index Medicus KW - Diagnosis, Differential KW - Humans KW - Aged KW - Follow-Up Studies KW - Male KW - Corneal Diseases -- chemically induced KW - Rifabutin -- adverse effects KW - HIV -- immunology KW - Endothelium, Corneal -- drug effects KW - Corneal Diseases -- metabolism KW - Endothelium, Corneal -- metabolism KW - Endothelium, Corneal -- pathology KW - Anti-Bacterial Agents -- adverse effects KW - Corneal Diseases -- pathology KW - Rifabutin -- pharmacokinetics KW - Anti-Bacterial Agents -- pharmacokinetics KW - HIV Seropositivity -- drug therapy KW - HIV Seropositivity -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68895416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Optometry+%28St.+Louis%2C+Mo.%29&rft.atitle=Human+immunodeficiency+virus-positive+patient+with+bilateral+corneal+endothelial+deposits.&rft.au=Boyer%2C+Stephen+P%3BGay%2C+Dax+A&rft.aulast=Boyer&rft.aufirst=Stephen&rft.date=2006-10-01&rft.volume=77&rft.issue=10&rft.spage=494&rft.isbn=&rft.btitle=&rft.title=Optometry+%28St.+Louis%2C+Mo.%29&rft.issn=15291839&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-07 N1 - Date created - 2006-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Physiological and subjective responding to alcohol cue exposure in alcoholics and control subjects: evidence for appetitive responding. AN - 68874714; 16604310 AB - 36 alcoholic patients, recruited from a treatment program, and 20 non-alcohol abusing control subjects were tested for their reactions to alcohol and non-alcohol cues. The cue exposure paradigm included audio-visual (video), tactile, olfactory, and guided imagery cue components related to alcohol and non-alcohol beverages. Response measures were analyzed for significant difference based on alcohol and non-alcohol cue and patient type. Among the subjective ratings, alcohol cue specific increases in alcohol craving, desire to drink, alcohol-like high, positive drinking expectancies and alcohol-like withdrawal were seen in alcoholic subjects. Among the physiological measures, alcohol cue specific increases in salivation were seen in alcoholic subjects. Changes in heart rate, skin conductance and temperature were not specific to alcohol cues, or to alcoholic patients. The smelling of alcohol had the greatest impact on alcohol craving and skin conductance in alcoholic subjects. These findings demonstrate robust subjective effects, and weak physiological effects, in response to a multidimensional alcohol cue exposure paradigm. The response profile indicates cue reactivity in alcoholics as an appetitive based form of alcohol craving. JF - Journal of neural transmission (Vienna, Austria : 1996) AU - Reid, M S AU - Flammino, F AU - Starosta, A AU - Palamar, J AU - Franck, J AD - Department of Psychiatry, New York University School of Medicine, New York, NY 10010, USA. malcolm.reid@med.va.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1519 EP - 1535 VL - 113 IS - 10 SN - 0300-9564, 0300-9564 KW - Index Medicus KW - Humans KW - Adult KW - Heart Rate -- physiology KW - Body Temperature -- physiology KW - Salivation -- physiology KW - Male KW - Galvanic Skin Response -- physiology KW - Female KW - Substance Withdrawal Syndrome -- physiopathology KW - Cues KW - Alcoholism -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68874714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neural+transmission+%28Vienna%2C+Austria+%3A+1996%29&rft.atitle=Physiological+and+subjective+responding+to+alcohol+cue+exposure+in+alcoholics+and+control+subjects%3A+evidence+for+appetitive+responding.&rft.au=Reid%2C+M+S%3BFlammino%2C+F%3BStarosta%2C+A%3BPalamar%2C+J%3BFranck%2C+J&rft.aulast=Reid&rft.aufirst=M&rft.date=2006-10-01&rft.volume=113&rft.issue=10&rft.spage=1519&rft.isbn=&rft.btitle=&rft.title=Journal+of+neural+transmission+%28Vienna%2C+Austria+%3A+1996%29&rft.issn=03009564&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-02 N1 - Date created - 2006-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized trial of an intervention to facilitate recycling for relapsed smokers. AN - 68860182; 16979453 AB - Tobacco dependence is a chronic condition requiring repeat treatment and long-term follow-up. However, current evidence regarding best approaches to providing these services is fairly limited. This study assessed the effectiveness of an intervention for increasing repeat tobacco-dependence treatment in a population of relapsed smokers. The study was a multicenter randomized controlled trial. Patients aged 19 and older receiving a prescription for nicotine replacement therapy or bupropion for smoking cessation in 2002 at one of five participating Veterans Affairs (VA) facilities were eligible. A total of 1900 eligible veterans were randomized to (1) patient phone call to assess smoking status, quit challenges, and treatment preferences, and computerized progress note to providers communicating this information (intervention); or (2) usual care (control). Outcomes, assessed in 2003, included the proportion of patients receiving repeat pharmacologic or behavioral smoking-cessation treatment in the 6-month follow-up period (assessed from VA pharmacy and outpatient data), 7-day point prevalence abstinence, and satisfaction (assessed by patient survey). Thirty-four percent of intervention participants versus 22% of controls received treatment for tobacco dependence in the follow-up period (p = 0.0001). Thirty-two percent of intervention participants versus 21% of controls received pharmacologic treatment (p = 0.0001), and 12% of intervention subjects versus 8% of controls received behavioral treatment (p = 0.005). Abstinence rates at follow-up were 25% for intervention subjects and 22% for controls (p = 0.15). Intervention subjects were more likely than controls to report being satisfied with the general smoking-cessation help (87% vs 82%, p = 0.01), as well as the pharmacologic help that they received from the VA (89 vs 84%, p = 0.01). The intervention significantly increased repeat treatment rates and satisfaction with services but did not have a significant effect on abstinence rates. JF - American journal of preventive medicine AU - Partin, Melissa R AU - An, Lawrence C AU - Nelson, David B AU - Nugent, Sean AU - Snyder, Annamay AU - Fu, Steven S AU - Willenbring, Mark L AU - Joseph, Anne M AD - Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA. Melissa.Partin@va.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 293 EP - 299 VL - 31 IS - 4 SN - 0749-3797, 0749-3797 KW - Bupropion KW - 01ZG3TPX31 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - United States KW - Retreatment -- methods KW - Patient Satisfaction KW - Humans KW - Adult KW - Aged KW - Outcome Assessment (Health Care) KW - Middle Aged KW - Follow-Up Studies KW - Secondary Prevention KW - Male KW - Female KW - Hospitals, Veterans KW - Veterans KW - Tobacco Use Disorder -- rehabilitation KW - Smoking Cessation -- methods KW - Nicotine -- administration & dosage KW - Behavior Therapy -- methods KW - Bupropion -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68860182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+preventive+medicine&rft.atitle=Randomized+trial+of+an+intervention+to+facilitate+recycling+for+relapsed+smokers.&rft.au=Partin%2C+Melissa+R%3BAn%2C+Lawrence+C%3BNelson%2C+David+B%3BNugent%2C+Sean%3BSnyder%2C+Annamay%3BFu%2C+Steven+S%3BWillenbring%2C+Mark+L%3BJoseph%2C+Anne+M&rft.aulast=Partin&rft.aufirst=Melissa&rft.date=2006-10-01&rft.volume=31&rft.issue=4&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=American+journal+of+preventive+medicine&rft.issn=07493797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-29 N1 - Date created - 2006-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epithelial cell polarity and hypoxia influence heme oxygenase-1 expression by heme in renal epithelial cells. AN - 68835696; 16622174 AB - Induction of heme oxygenase-1 (HO-1) in renal tubules occurs as an adaptive and beneficial response in acute renal failure (ARF) following ischemia and nephrotoxins. Using an in vitro model of polarized Madin-Darby canine kidney (MDCK) epithelial cells, we examined apical and basolateral cell surface sensitivity to HO-1 induction by heme. Basolateral exposure to 5 microM hemin (heme chloride) resulted in higher HO-1 induction than did apical exposure. The peak induction of HO-1 by basolateral application of hemin occurred between 12 and 18 h of exposure and was dose dependent. Similar cell surface sensitivity to hemin-induced HO-1 expression was observed using a mouse cortical collecting duct cell line (94D cells). Hepatocyte growth factor (HGF) is known to decrease cell polarity of MDCK cells. Following pretreatment with HGF, apically applied hemin gave greater stimulation of HO-1 expression, whereas HGF alone did not induce HO-1. We also examined the effect of hypoxia on hemin-mediated HO-1 induction. MDCK cells were subjected to hypoxia (1% O(2)) for 24 h to simulate the effects of ischemic ARF. Under hypoxic conditions, both apical as well as basolateral surfaces of MDCK were more sensitive to HO-1 induction by hemin. Hypoxia alone did not induce HO-1 but appeared to potentiate both apical and basolateral sensitivity to hemin-mediated induction. These data demonstrate that the induction of HO-1 expression in polarized renal epithelia by heme is achieved primarily via basolateral exposure. However, under conditions of altered renal epithelial cell polarity and hypoxia, increased HO-1 induction occurs following apical exposure to heme. JF - American journal of physiology. Renal physiology AU - Basireddy, Mahesh AU - Lindsay, Jason T AU - Agarwal, Anupam AU - Balkovetz, Daniel F AD - Veterans Administration Medical Center, Birmingham, AL, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - F790 EP - F795 VL - 291 IS - 4 SN - 1931-857X, 1931-857X KW - Heme KW - 42VZT0U6YR KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - Index Medicus KW - Animals KW - Heme -- pharmacology KW - Dogs KW - Enzyme Induction KW - Urothelium -- physiology KW - Cell Membrane -- physiology KW - Heme -- metabolism KW - Cell Hypoxia KW - Cell Line KW - Cell Polarity -- physiology KW - Heme Oxygenase-1 -- biosynthesis KW - Epithelial Cells -- physiology KW - Kidney -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68835696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Renal+physiology&rft.atitle=Epithelial+cell+polarity+and+hypoxia+influence+heme+oxygenase-1+expression+by+heme+in+renal+epithelial+cells.&rft.au=Basireddy%2C+Mahesh%3BLindsay%2C+Jason+T%3BAgarwal%2C+Anupam%3BBalkovetz%2C+Daniel+F&rft.aulast=Basireddy&rft.aufirst=Mahesh&rft.date=2006-10-01&rft.volume=291&rft.issue=4&rft.spage=F790&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Renal+physiology&rft.issn=1931857X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-26 N1 - Date created - 2006-09-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Action plan for enhancing global collaboration on alcoholic liver and pancreatic diseases: white paper. AN - 68835580; 16958661 JF - Journal of gastroenterology and hepatology AU - Pandol, Steve J AU - Tsukamoto, Hide AD - Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA. stephen.pandol@med.va.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - S109 EP - S110 VL - 21 Suppl 3 SN - 0815-9319, 0815-9319 KW - Index Medicus KW - Humans KW - Congresses as Topic KW - Global Health KW - Pancreatitis, Alcoholic -- prevention & control KW - Liver Diseases, Alcoholic -- prevention & control KW - International Cooperation KW - Biomedical Research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68835580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gastroenterology+and+hepatology&rft.atitle=Action+plan+for+enhancing+global+collaboration+on+alcoholic+liver+and+pancreatic+diseases%3A+white+paper.&rft.au=Pandol%2C+Steve+J%3BTsukamoto%2C+Hide&rft.aulast=Pandol&rft.aufirst=Steve&rft.date=2006-10-01&rft.volume=21+Suppl+3&rft.issue=&rft.spage=S109&rft.isbn=&rft.btitle=&rft.title=Journal+of+gastroenterology+and+hepatology&rft.issn=08159319&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-29 N1 - Date created - 2006-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevention of chronic anthracycline cardiotoxicity in the adult Fischer 344 rat by dexrazoxane and effects on iron metabolism. AN - 68601912; 16555089 AB - Anthracyclines, such as doxorubicin and daunorubicin, continue to be widely used in the treatment of cancer, although they share the adverse effect of chronic, cumulative dose-related cardiotoxicity. The only approved treatment in prevention of anthracycline cardiotoxicity is dexrazoxane, a putative iron chelator. Previous in vitro studies have shown that disorders of iron metabolism, including altered IRP1-IRE binding, may be an important mechanism of anthracycline cardiotoxicity. This study examined the role of IRP1-IRE binding ex vivo in a chronic model of daunorubicin cardiotoxicity in the Fischer 344 rat and whether dexrazoxane could prevent any daunorubicin-induced changes in IRP1 binding. Young adult (5-6 months) Fischer 344 rats received daunorubicin (2.5 mg/kg iv once per week for 6 weeks) with and without pretreatment with dexrazoxane (50 mg/kg ip). Other groups received saline (controls) or dexrazoxane alone. Rats were killed either 4 h or 2 weeks after the last dose of daunorubicin to assess IRP1-IRE binding. Contractility (dF/dt) of atrial tissue, obtained from rats 2 weeks after the last dose of daunorubicin, was significantly reduced in daunorubicin-treated compared to control rats. Dexrazoxane pretreatment protected against the daunorubicin-induced decrease in atrial dF/dt. However, left ventricular IRP1/IRE binding was not affected by daunorubicin treatment either 4 h or 2 weeks after the last dose of daunorubicin. IRP1 binding may not be altered in the rat model of chronic anthracycline cardiotoxicity. JF - Cancer chemotherapy and pharmacology AU - Cusack, B J AU - Gambliel, H AU - Musser, B AU - Hadjokas, N AU - Shadle, S E AU - Charlier, H AU - Olson, R D AD - Research Service, VA Medical Center (111), 500 W Fort St, Boise, ID, 83702, USA. barry.cusack@med.va.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 517 EP - 526 VL - 58 IS - 4 SN - 0344-5704, 0344-5704 KW - Antibiotics, Antineoplastic KW - 0 KW - Chelating Agents KW - Iron-Regulatory Proteins KW - Razoxane KW - 5AR83PR647 KW - Iron Regulatory Protein 1 KW - EC 4.2.1.3 KW - Daunorubicin KW - ZS7284E0ZP KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Male KW - Razoxane -- therapeutic use KW - Chelating Agents -- therapeutic use KW - Daunorubicin -- toxicity KW - Heart Diseases -- chemically induced KW - Iron Regulatory Protein 1 -- metabolism KW - Iron-Regulatory Proteins -- metabolism KW - Heart Diseases -- prevention & control KW - Daunorubicin -- antagonists & inhibitors KW - Antibiotics, Antineoplastic -- toxicity KW - Antibiotics, Antineoplastic -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68601912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Prevention+of+chronic+anthracycline+cardiotoxicity+in+the+adult+Fischer+344+rat+by+dexrazoxane+and+effects+on+iron+metabolism.&rft.au=Cusack%2C+B+J%3BGambliel%2C+H%3BMusser%2C+B%3BHadjokas%2C+N%3BShadle%2C+S+E%3BCharlier%2C+H%3BOlson%2C+R+D&rft.aulast=Cusack&rft.aufirst=B&rft.date=2006-10-01&rft.volume=58&rft.issue=4&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-24 N1 - Date created - 2006-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An evaluation of five bedside information products using a user-centered, task-oriented approach. AN - 57674597; 477776 AB - Purpose: The paper compares several bedside information tools using user-centered, task-oriented measures to assist those making or supporting purchasing decisions. Methods: Eighteen potential users were asked to attempt to answer clinical questions using five commercial products (ACP's PIER, DISEASEDEX, FIRSTConsult, InfoRetriever, and UpToDate). Users evaluated each tool for ease-of-use and user satisfaction. The average number of questions answered and user satisfaction were measured for each product. Results: Results show no significant differences in user perceptions of content quality. However, user interaction measures (such as screen layout) show a significant preference for the UpToDate product. In addition, users found answers to significantly more questions using UpToDate. Conclusion: When evaluating electronic products designed for use at the point of care, the user interaction aspects of a product become as important as more traditional content-based measures of quality. Actual or potential users of such products are appropriately equipped to identify which products rate the highest on these measures. (Author abstract) JF - Journal of the Medical Library Association ( JMLA ) AU - Campbell, Rose AU - Ash, Joan AD - Department of Medical Informatics and Clinical Epidemiology, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA rose.campbell@va.gov Y1 - 2006/10// PY - 2006 DA - October 2006 PB - Medical Library Association VL - 94 IS - 4 SN - 1536-5050, 1536-5050 KW - Comparative studies KW - Full text databases KW - DISEASEDEX KW - InfoRetriever KW - PIER KW - Health care KW - FIRSTConsult KW - Online databases KW - Medicine KW - UpToDate KW - Online information retrieval KW - 13.11: NETWORKS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57674597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.atitle=An+evaluation+of+five+bedside+information+products+using+a+user-centered%2C+task-oriented+approach.&rft.au=Campbell%2C+Rose%3BAsh%2C+Joan&rft.aulast=Campbell&rft.aufirst=Rose&rft.date=2006-10-01&rft.volume=94&rft.issue=4&rft.spage=np&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.issn=15365050&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2007-02-27 N1 - Document feature - il. tbls. refs. N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Online information retrieval; Online databases; Full text databases; Health care; Medicine; PIER; DISEASEDEX; FIRSTConsult; InfoRetriever; UpToDate; Comparative studies ER - TY - JOUR T1 - Posttraumatic Growth Among Gulf War I Veterans: The Predictive Role Of Deployment-Related Experiences And Background Characteristics AN - 57162555; 200709605 AB - In this study, we identified deployment-related and demographic predictors of several factors of posttraumatic growth in a sample of combat-exposed Gulf War I veterans. Participants were obtained via a Veterans Administration registry of Gulf War I veterans and were mailed a survey containing a number of scales assessing predeployment, deployment, and postdeployment factors from the Deployment Risk and Resilience Inventory and the Posttraumatic Growth Inventory. Military status and perceived threat were significant predictors of appreciation of life. Relating to others, personal strength, and posttraumatic growth as a whole were best predicted by the postdeployment variable of social support. Minority status was the only significant predictor of new possibilities, with ethnic minorities reporting more new possibilities postdeployment. Limitations and suggestions for future research are discussed. Adapted from the source document. JF - Journal of Loss & Trauma AU - Maguen, Shira AU - Vogt, Dawne S AU - King, Lynda A AU - King, Daniel W AU - Litz, Brett T AD - San Francisco VA Medical Center, PTSD Program (116-P), San Francisco. E-mail: Shira.Maguen@va.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 373 EP - 388 PB - Taylor & Francis VL - 11 IS - 5 SN - 1532-5024, 1532-5024 KW - Veterans KW - Posttraumatic stress disorder KW - Predictors KW - Recovery KW - Life satisfaction KW - Military personnel KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57162555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Loss+%26+Trauma&rft.atitle=Posttraumatic+Growth+Among+Gulf+War+I+Veterans%3A+The+Predictive+Role+Of+Deployment-Related+Experiences+And+Background+Characteristics&rft.au=Maguen%2C+Shira%3BVogt%2C+Dawne+S%3BKing%2C+Lynda+A%3BKing%2C+Daniel+W%3BLitz%2C+Brett+T&rft.aulast=Maguen&rft.aufirst=Shira&rft.date=2006-10-01&rft.volume=11&rft.issue=5&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Journal+of+Loss+%26+Trauma&rft.issn=15325024&rft_id=info:doi/10.1080%2F15325020600672004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Predictors; Recovery; Military personnel; Veterans; Life satisfaction DO - http://dx.doi.org/10.1080/15325020600672004 ER - TY - JOUR T1 - A Challenging but Critical Endeavor: Balancing Responsiveness and Rigor in Community-Based Participatory Research AN - 57060949; 200616802 AB - Provides commentary in response to an article in the same journal issue, which provides an example of community-based participatory research in action as part of a strategy to increase breast cancer early detection in New York City. The author describes common needs assessment errors to be avoided by practitioners. References. [Reprinted by permission of Sage Publications Inc., copyright 2006, Society for Public Health Education.] JF - Health Education & Behavior AU - Partin, Melissa R AD - Center Chronic Disease Outcomes Research, Minneapolis VA Medical Center, MN melissa.partin@va.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 574 EP - 577 PB - Sage Publications, Thousand Oaks CA VL - 33 IS - 5 SN - 1090-1981, 1090-1981 KW - Detection KW - Evaluative research KW - Breast cancer KW - Community based KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57060949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+%26+Behavior&rft.atitle=A+Challenging+but+Critical+Endeavor%3A+Balancing+Responsiveness+and+Rigor+in+Community-Based+Participatory+Research&rft.au=Partin%2C+Melissa+R&rft.aulast=Partin&rft.aufirst=Melissa&rft.date=2006-10-01&rft.volume=33&rft.issue=5&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=Health+Education+%26+Behavior&rft.issn=10901981&rft_id=info:doi/10.1177%2F1090198106288511 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-03 N1 - Last updated - 2016-09-27 N1 - CODEN - HEDBFS N1 - SubjectsTermNotLitGenreText - Community based; Evaluative research; Breast cancer; Detection DO - http://dx.doi.org/10.1177/1090198106288511 ER - TY - JOUR T1 - Feasibility of Automated Detection of Advanced Sleep Disordered Breathing Utilizing an Implantable Pacemaker Ventilation Sensor AN - 20098859; 7169150 AB - This study tested the feasibility of automatically detecting advanced sleep disordered breathing (SDB) from a pacemaker trans-thoracic impedance sensor. Background: SDB is prevalent yet under-diagnosed in patients with cardiovascular disease. The potential for automated detection of SDB in patients receiving pacemakers with respiration sensors has not been fully explored. We hypothesized that the trans-thoracic impedance sensor could be utilized for automatic detection of advanced SDB. Methods: Patients underwent overnight polysomnography (PSG). The pacemaker trans-thoracic impedance signal was simultaneously recorded and time synchronized with the polysomnograph. Cardiovascular health variables were abstracted from medical records. Apnea was defined as cessation of inspiratory airflow lasting 10 seconds or longer. Hypopnea was defined as a reduction of tidal volume of at least 30% from baseline tidal volume, lasting 10 seconds or more. A computer algorithm (PM-A) was developed to automatically detect SDB from the pacemaker impedance sensor data. The performance of automated SDB detection was compared against PSG. Results: Sixty patients (aged 69 plus or minus 12 years, 45 males) were studied. Advanced SDB (moderate or severe) was diagnosed in 40 patients. Severe SDB (apnea-hypopnea index [AHI] greater than or equal to 30) was diagnosed in 32 patients (53%), but only 5 patients had prior diagnosis of the disease. Moderate SDB (30 > AHI > 15) was diagnosed in 8 patients of whom only two were previously diagnosed. Cardiovascular health variables did not predict the presence of advanced SDB. PM-A derived AHI correlated with that of the PSG (r = 0.80, P < 0.01). The algorithm identified patients with advanced SDB with 82% sensitivity and 88% specificity. Conclusions: It is feasible to automatically measure SDB severity using a pacemaker trans-thoracic impedance sensor. Advanced SDB was frequently undiagnosed in this cohort of pacemaker patients. JF - Pacing and Clinical Electrophysiology AU - Shalaby, Alaa AU - Atwood, Charles AU - Hansen, Claudius AU - Konermann, Martin AU - Jamnadas, Pradip AU - Lee, Kent AU - Willems, Roger AU - Hartley, Jesse AU - Stahmann, Jeffrey AU - Kwok, Jonathan AU - NI, Quan AU - Neuzner, Joerg AD - Address for reprints: Alaa A Shalaby, M.D., F.A.C.C., Division of Cardiology, Pittsburgh VA Healthcare System, University of Pittsburgh, 111(C) University Drive C, Pittsburgh, PA 15240, Alaa.Shalaby@med.va.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1036 EP - 1043 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 29 IS - 10 SN - 0147-8389, 0147-8389 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Sleep disorders KW - Ventilation KW - medical records KW - Apnea KW - Respiration KW - Computers KW - Algorithms KW - Pacemakers KW - Electrophysiology KW - Sleep KW - Cardiovascular diseases KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20098859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pacing+and+Clinical+Electrophysiology&rft.atitle=Feasibility+of+Automated+Detection+of+Advanced+Sleep+Disordered+Breathing+Utilizing+an+Implantable+Pacemaker+Ventilation+Sensor&rft.au=Shalaby%2C+Alaa%3BAtwood%2C+Charles%3BHansen%2C+Claudius%3BKonermann%2C+Martin%3BJamnadas%2C+Pradip%3BLee%2C+Kent%3BWillems%2C+Roger%3BHartley%2C+Jesse%3BStahmann%2C+Jeffrey%3BKwok%2C+Jonathan%3BNI%2C+Quan%3BNeuzner%2C+Joerg&rft.aulast=Shalaby&rft.aufirst=Alaa&rft.date=2006-10-01&rft.volume=29&rft.issue=10&rft.spage=1036&rft.isbn=&rft.btitle=&rft.title=Pacing+and+Clinical+Electrophysiology&rft.issn=01478389&rft_id=info:doi/10.1111%2Fj.1540-8159.2006.00496.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - SuppNotes - Figures, 3; tables, 3; references, 47. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Ventilation; Sleep disorders; Apnea; medical records; Computers; Sleep; Respiration; Algorithms; Cardiovascular diseases; Electrophysiology; Pacemakers DO - http://dx.doi.org/10.1111/j.1540-8159.2006.00496.x ER - TY - JOUR T1 - Recognition distance of pedestrian traffic signals by individuals with low vision AN - 19609445; 7325951 AB - Forty-one individuals with moderate-to-severe vision loss participated in a study to determine the minimum distance they required to correctly identity three different pedestrian traffic icon symbols, one of which was presented with an augmented light source. We found that subjects could identify the WALK icon without the augmented light source information, or animated eyes, from farther away than either the WALK icon with the augmented light source information or the DON'T WALK icon. These results differ from those of a previous study, which found that subjects could correctly identify the WALK icon with the augmented light source from a greater distance than the WALK or DON'T WALK icons without the augmented light source. JF - Journal of Rehabilitation Research and Development AU - Williams, MD AU - Van Houten, R AU - Blasch, B B AD - RR&D Center of Excellence for Aging Veterans with Vision Loss (151 R), Atlanta VA Medical Center, Decatur, GA 30033, mike.wiilliams2@med.va.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 771 EP - 776 VL - 43 IS - 6 SN - 0748-7711, 0748-7711 KW - Health & Safety Science Abstracts KW - traffic KW - light sources KW - Vision KW - pedestrians KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19609445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Recognition+distance+of+pedestrian+traffic+signals+by+individuals+with+low+vision&rft.au=Williams%2C+MD%3BVan+Houten%2C+R%3BBlasch%2C+B+B&rft.aulast=Williams&rft.aufirst=MD&rft.date=2006-10-01&rft.volume=43&rft.issue=6&rft.spage=771&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2005.02.0040 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - traffic; Vision; light sources; pedestrians DO - http://dx.doi.org/10.1682/JRRD.2005.02.0040 ER - TY - JOUR T1 - Evaluation of treatment effects in Alzheimer's and other neurodegenerative diseases by MRI and MRS AN - 19500096; 8632169 AB - Neurodegeneration refers to a large clinically and pathologically heterogeneous disease entity associated with slowly progressive neuronal loss in different anatomical and functional systems of the brain. Neurodegenerative diseases often affect cognition, e.g. Alzheimer's disease (AD), dementia with Lewy bodies and vascular dementia, or different aspects of the motor system, e.g., amyotrophic lateral sclerosis, Parkinson's disease and ataxic disorders. Owing to increasing knowledge about the mechanisms leading to neurodegeneration, the development of treatments able to modify the neurodegenerative process becomes possible for the first time. Currently, clinical outcome measures are used to assess the efficacy of such treatments. However, most clinical outcome measures have a low test-retest reliability and thus considerable measurement variance. Therefore, large patient populations and long observation times are needed to detect treatment effects. Furthermore, clinical outcome measures cannot distinguish between symptomatic and disease-modifying treatment effects. Therefore, alternative biomarkers including neuroimaging may take on a more important role in this process. Because MR scanners are widely available and allow for non-invasive detection and quantification of changes in brain structure and metabolism, there is increasing interest in the use of MRI/MRS to monitor objectively treatment effects in clinical trials of neurodegenerative diseases. Particularly volumetric MRI has been used to measure atrophy rates in treatment trials of AD because the relationship between atrophic changes and neuron loss is well established and correlates well with clinical measures. More research is needed to determine the value of other MR modalities, i.e. diffusion, perfusion and functional MRI and MR spectroscopy, for clinical trials with neuroprotective drugs. JF - NMR in Biomedicine AU - Mueller, S G AU - Schuff, N AU - Weiner, M W AD - Center of Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, Department of Radiology, University of California San Francisco, San Francisco, CA 94121, USA, mweiner@itsa.ucsf.edu Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 655 EP - 668 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 19 IS - 6 SN - 0952-3480, 0952-3480 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Parkinson's disease KW - Functional magnetic resonance imaging KW - Magnetic resonance imaging KW - Alzheimer's disease KW - Neuroprotection KW - Clinical trials KW - vascular dementia KW - Cognition KW - Magnetic resonance spectroscopy KW - Dementia disorders KW - Motor systems KW - N.M.R. KW - Diffusion KW - Drugs KW - Perfusion KW - biomarkers KW - Lewy bodies KW - Neurodegenerative diseases KW - Movement disorders KW - Amyotrophic lateral sclerosis KW - Atrophy KW - Metabolism KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19500096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Evaluation+of+treatment+effects+in+Alzheimer%27s+and+other+neurodegenerative+diseases+by+MRI+and+MRS&rft.au=Mueller%2C+S+G%3BSchuff%2C+N%3BWeiner%2C+M+W&rft.aulast=Mueller&rft.aufirst=S&rft.date=2006-10-01&rft.volume=19&rft.issue=6&rft.spage=655&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.1062 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Neurodegenerative diseases; Alzheimer's disease; Clinical trials; Magnetic resonance imaging; Functional magnetic resonance imaging; Amyotrophic lateral sclerosis; Cognition; Lewy bodies; Atrophy; Neuroimaging; Drugs; vascular dementia; biomarkers; Motor systems; Perfusion; Diffusion; Movement disorders; Dementia disorders; Magnetic resonance spectroscopy; N.M.R.; Neuroprotection; Metabolism; Parkinson's disease DO - http://dx.doi.org/10.1002/nbm.1062 ER - TY - CPAPER T1 - Vacuum Assisted Therapy for Pressure Ulcers in Patients with Spinal Cord Injury T2 - 52nd Annual Conference of American Paraplegia Society AN - 40379837; 4429535 JF - 52nd Annual Conference of American Paraplegia Society AU - Spungen, Ann M Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Injuries KW - Vacuum KW - Ulcers KW - Pressure KW - Spinal cord injury KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40379837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=Vacuum+Assisted+Therapy+for+Pressure+Ulcers+in+Patients+with+Spinal+Cord+Injury&rft.au=Spungen%2C+Ann+M&rft.aulast=Spungen&rft.aufirst=Ann&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Autonomic Buffering of Blood Pressure is Altered in Tetraplegia T2 - 52nd Annual Conference of American Paraplegia Society AN - 40378808; 4429516 JF - 52nd Annual Conference of American Paraplegia Society AU - LaFountain, Michael F Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Blood pressure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40378808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=Autonomic+Buffering+of+Blood+Pressure+is+Altered+in+Tetraplegia&rft.au=LaFountain%2C+Michael+F&rft.aulast=LaFountain&rft.aufirst=Michael&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Leg Cycle Functional Electrical Stimulation Exercise on Hemostasis in Persons with Spinal Cord Injury T2 - 52nd Annual Conference of American Paraplegia Society AN - 40378770; 4429545 JF - 52nd Annual Conference of American Paraplegia Society AU - Kahn, Nighat Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Injuries KW - Leg KW - Electrical stimuli KW - Hemostasis KW - Physical training KW - Spinal cord injury UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40378770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=Effects+of+Leg+Cycle+Functional+Electrical+Stimulation+Exercise+on+Hemostasis+in+Persons+with+Spinal+Cord+Injury&rft.au=Kahn%2C+Nighat&rft.aulast=Kahn&rft.aufirst=Nighat&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Depression, Cognitive Loss and Fatigue in Veterans with MS: Awareness and Approaches T2 - 52nd Annual Conference of American Paraplegia Society AN - 40378762; 4429496 JF - 52nd Annual Conference of American Paraplegia Society AU - Haselkorn, Jodie K Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Fatigue KW - Depression KW - Cognitive ability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40378762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=Depression%2C+Cognitive+Loss+and+Fatigue+in+Veterans+with+MS%3A+Awareness+and+Approaches&rft.au=Haselkorn%2C+Jodie+K&rft.aulast=Haselkorn&rft.aufirst=Jodie&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammatory Non-Traumatic Spinal Cord Injury T2 - 52nd Annual Conference of American Paraplegia Society AN - 40378733; 4429495 JF - 52nd Annual Conference of American Paraplegia Society AU - Ruff, Robert L Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Injuries KW - Inflammation KW - Spinal cord injury UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40378733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=Inflammatory+Non-Traumatic+Spinal+Cord+Injury&rft.au=Ruff%2C+Robert+L&rft.aulast=Ruff&rft.aufirst=Robert&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Energy Expenditure after Spinal Cord Injury T2 - 52nd Annual Conference of American Paraplegia Society AN - 40378246; 4429511 JF - 52nd Annual Conference of American Paraplegia Society AU - Collins, Eileen Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Injuries KW - Energy expenditure KW - Spinal cord injury UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40378246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=Energy+Expenditure+after+Spinal+Cord+Injury&rft.au=Collins%2C+Eileen&rft.aulast=Collins&rft.aufirst=Eileen&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Copper Deficiency Secondary to Gastric Bypass Resulting in Myelopathy T2 - 52nd Annual Conference of American Paraplegia Society AN - 40378216; 4429508 JF - 52nd Annual Conference of American Paraplegia Society AU - Nambiar, Prabhakaran K Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Copper KW - Spinal cord KW - Gastric bypass UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40378216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=Copper+Deficiency+Secondary+to+Gastric+Bypass+Resulting+in+Myelopathy&rft.au=Nambiar%2C+Prabhakaran+K&rft.aulast=Nambiar&rft.aufirst=Prabhakaran&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Arterial Circulation to the Legs in Spinal Cord Injury T2 - 52nd Annual Conference of American Paraplegia Society AN - 40377487; 4429536 JF - 52nd Annual Conference of American Paraplegia Society AU - Deitrick, George A Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Injuries KW - Leg KW - Spinal cord injury KW - Blood circulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40377487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=Arterial+Circulation+to+the+Legs+in+Spinal+Cord+Injury&rft.au=Deitrick%2C+George+A&rft.aulast=Deitrick&rft.aufirst=George&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Digital Imaging System versus Manual Method for Pressure Ulcer Quantification T2 - 52nd Annual Conference of American Paraplegia Society AN - 40376794; 4429539 JF - 52nd Annual Conference of American Paraplegia Society AU - Relova, Rona Margaret Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Imaging techniques KW - Ulcers KW - Pressure KW - Manuals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40376794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=Digital+Imaging+System+versus+Manual+Method+for+Pressure+Ulcer+Quantification&rft.au=Relova%2C+Rona+Margaret&rft.aulast=Relova&rft.aufirst=Rona&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Bowel Care Survey to Assess Quality of Life in Persons with Spinal Cord Injury T2 - 52nd Annual Conference of American Paraplegia Society AN - 40376764; 4429534 JF - 52nd Annual Conference of American Paraplegia Society AU - Spungen, Ann M Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Quality of life KW - Injuries KW - Intestine KW - Spinal cord injury UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40376764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=A+Bowel+Care+Survey+to+Assess+Quality+of+Life+in+Persons+with+Spinal+Cord+Injury&rft.au=Spungen%2C+Ann+M&rft.aulast=Spungen&rft.aufirst=Ann&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Use of Nasal Expiratory Pressure to Assess Expiratory Muscle Strength in Tetraplegia T2 - 52nd Annual Conference of American Paraplegia Society AN - 40376707; 4429529 JF - 52nd Annual Conference of American Paraplegia Society AU - Schilero, Gregory J Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Muscles KW - Pressure KW - Muscular strength UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40376707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=Novel+Use+of+Nasal+Expiratory+Pressure+to+Assess+Expiratory+Muscle+Strength+in+Tetraplegia&rft.au=Schilero%2C+Gregory+J&rft.aulast=Schilero&rft.aufirst=Gregory&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characteristics of Veterans with SCI Hospitalized for the Treatment of Severe Pressure Ulcers T2 - 52nd Annual Conference of American Paraplegia Society AN - 40376623; 4429485 JF - 52nd Annual Conference of American Paraplegia Society AU - Guihan, Marylou Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Ulcers KW - Pressure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40376623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=Characteristics+of+Veterans+with+SCI+Hospitalized+for+the+Treatment+of+Severe+Pressure+Ulcers&rft.au=Guihan%2C+Marylou&rft.aulast=Guihan&rft.aufirst=Marylou&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - VA Cooperative Study: Anabolic Steroid Therapy on Pressure Ulcer Healing in Persons with SCI T2 - 52nd Annual Conference of American Paraplegia Society AN - 40376559; 4429484 JF - 52nd Annual Conference of American Paraplegia Society AU - Bauman, William A Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Ulcers KW - Pressure KW - Steroid hormones KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40376559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=VA+Cooperative+Study%3A+Anabolic+Steroid+Therapy+on+Pressure+Ulcer+Healing+in+Persons+with+SCI&rft.au=Bauman%2C+William+A&rft.aulast=Bauman&rft.aufirst=William&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Telemedicine Network for Wound Care in Spinal Cord Injury/Disorder T2 - 52nd Annual Conference of American Paraplegia Society AN - 40376065; 4429538 JF - 52nd Annual Conference of American Paraplegia Society AU - Ho, Chester H Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Injuries KW - Wounds KW - Spinal cord injury UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40376065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=Telemedicine+Network+for+Wound+Care+in+Spinal+Cord+Injury%2FDisorder&rft.au=Ho%2C+Chester+H&rft.aulast=Ho&rft.aufirst=Chester&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Healing Rate of Chronic Stage 3 and 4 Pressure Ulcers T2 - 52nd Annual Conference of American Paraplegia Society AN - 40375402; 4429486 JF - 52nd Annual Conference of American Paraplegia Society AU - Spungen, Ann M Y1 - 2006/09/06/ PY - 2006 DA - 2006 Sep 06 KW - Ulcers KW - Pressure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40375402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.atitle=Healing+Rate+of+Chronic+Stage+3+and+4+Pressure+Ulcers&rft.au=Spungen%2C+Ann+M&rft.aulast=Spungen&rft.aufirst=Ann&rft.date=2006-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=52nd+Annual+Conference+of+American+Paraplegia+Society&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006APSprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ET Phones Home: Networking from Your Desktop T2 - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AN - 40374634; 4427355 JF - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AU - Spillie, Anthony M Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 KW - Volatile organic compounds KW - Psychology KW - Reviews KW - Spinal cord injury KW - Experts KW - Pediatrics KW - Life span KW - Sexuality KW - Education KW - Adolescents KW - Complications KW - Psychotherapy KW - Etiology KW - Ethics KW - Species diversity KW - Longevity KW - Aetiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40374634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.atitle=ET+Phones+Home%3A+Networking+from+Your+Desktop&rft.au=Spillie%2C+Anthony+M&rft.aulast=Spillie&rft.aufirst=Anthony&rft.date=2006-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006AASCIPSWprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Support Group and Individual Psychotherapy Equally Effective in Reducing Depression during Rehabilitation T2 - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AN - 40374581; 4427329 JF - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AU - Duchnick, Jennifer J Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 KW - Volatile organic compounds KW - Psychology KW - Reviews KW - Spinal cord injury KW - Experts KW - Pediatrics KW - Life span KW - Sexuality KW - Education KW - Adolescents KW - Complications KW - Psychotherapy KW - Etiology KW - Ethics KW - Species diversity KW - Longevity KW - Aetiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40374581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.atitle=Support+Group+and+Individual+Psychotherapy+Equally+Effective+in+Reducing+Depression+during+Rehabilitation&rft.au=Duchnick%2C+Jennifer+J&rft.aulast=Duchnick&rft.aufirst=Jennifer&rft.date=2006-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006AASCIPSWprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treating Spinal Cord Injury Pain when Co-Morbid Depression is Suspected T2 - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AN - 40374529; 4427332 JF - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AU - Mutchler, Brian J Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 KW - Volatile organic compounds KW - Psychology KW - Reviews KW - Spinal cord injury KW - Experts KW - Pediatrics KW - Life span KW - Sexuality KW - Education KW - Adolescents KW - Complications KW - Psychotherapy KW - Etiology KW - Ethics KW - Species diversity KW - Longevity KW - Aetiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40374529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.atitle=Treating+Spinal+Cord+Injury+Pain+when+Co-Morbid+Depression+is+Suspected&rft.au=Mutchler%2C+Brian+J&rft.aulast=Mutchler&rft.aufirst=Brian&rft.date=2006-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006AASCIPSWprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deciphering Delirium, Dementia, and Depression T2 - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AN - 40374491; 4427319 JF - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AU - Hilsabeck, Robin C Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 KW - Volatile organic compounds KW - Psychology KW - Reviews KW - Spinal cord injury KW - Experts KW - Pediatrics KW - Life span KW - Sexuality KW - Education KW - Adolescents KW - Complications KW - Psychotherapy KW - Etiology KW - Ethics KW - Species diversity KW - Longevity KW - Aetiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40374491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.atitle=Deciphering+Delirium%2C+Dementia%2C+and+Depression&rft.au=Hilsabeck%2C+Robin+C&rft.aulast=Hilsabeck&rft.aufirst=Robin&rft.date=2006-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006AASCIPSWprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effective Interdisciplinary Interventions for Individuals with Spinal Cord Injuries and Personality Disorders: Part II T2 - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AN - 40372826; 4427296 JF - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AU - Major, Kenneth E Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 KW - Volatile organic compounds KW - Psychology KW - Reviews KW - Spinal cord injury KW - Experts KW - Pediatrics KW - Life span KW - Sexuality KW - Education KW - Adolescents KW - Complications KW - Psychotherapy KW - Etiology KW - Ethics KW - Species diversity KW - Longevity KW - Aetiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40372826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.atitle=Effective+Interdisciplinary+Interventions+for+Individuals+with+Spinal+Cord+Injuries+and+Personality+Disorders%3A+Part+II&rft.au=Major%2C+Kenneth+E&rft.aulast=Major&rft.aufirst=Kenneth&rft.date=2006-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006AASCIPSWprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effective Interdisciplinary Interventions for Individuals with Spinal Cord Injuries and Personality Disorders: Part I T2 - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AN - 40372800; 4427295 JF - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AU - Dematatis, Anna P Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 KW - Volatile organic compounds KW - Psychology KW - Reviews KW - Spinal cord injury KW - Experts KW - Pediatrics KW - Life span KW - Sexuality KW - Education KW - Adolescents KW - Complications KW - Psychotherapy KW - Etiology KW - Ethics KW - Species diversity KW - Longevity KW - Aetiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40372800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.atitle=Effective+Interdisciplinary+Interventions+for+Individuals+with+Spinal+Cord+Injuries+and+Personality+Disorders%3A+Part+I&rft.au=Dematatis%2C+Anna+P&rft.aulast=Dematatis&rft.aufirst=Anna&rft.date=2006-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006AASCIPSWprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Returning Veteran from Iraq: Barriers and Accessibility to Compassionate Interdisciplinary Rehabilitation T2 - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AN - 40372306; 4427351 JF - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AU - Jackson, Shirley A Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 KW - Iraq KW - Volatile organic compounds KW - Psychology KW - Reviews KW - Spinal cord injury KW - Experts KW - Pediatrics KW - Life span KW - Sexuality KW - Education KW - Adolescents KW - Complications KW - Psychotherapy KW - Etiology KW - Ethics KW - Species diversity KW - Longevity KW - Aetiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40372306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.atitle=A+Returning+Veteran+from+Iraq%3A+Barriers+and+Accessibility+to+Compassionate+Interdisciplinary+Rehabilitation&rft.au=Jackson%2C+Shirley+A&rft.aulast=Jackson&rft.aufirst=Shirley&rft.date=2006-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006AASCIPSWprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sexual Health Services at a VA Spinal Cord Injury/Dysfunction Center T2 - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AN - 40372204; 4427354 JF - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AU - Cass-Prost, Angela E Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 KW - Volatile organic compounds KW - Psychology KW - Reviews KW - Spinal cord injury KW - Experts KW - Pediatrics KW - Life span KW - Sexuality KW - Education KW - Adolescents KW - Complications KW - Psychotherapy KW - Etiology KW - Ethics KW - Species diversity KW - Longevity KW - Aetiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40372204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.atitle=Sexual+Health+Services+at+a+VA+Spinal+Cord+Injury%2FDysfunction+Center&rft.au=Cass-Prost%2C+Angela+E&rft.aulast=Cass-Prost&rft.aufirst=Angela&rft.date=2006-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006AASCIPSWprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vocational Rehabilitation Needs Assessment with Veterans with Spinal Cord Injury T2 - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AN - 40372126; 4427341 JF - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AU - Ottomanelli, Lisa A Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 KW - Volatile organic compounds KW - Psychology KW - Reviews KW - Spinal cord injury KW - Experts KW - Pediatrics KW - Life span KW - Sexuality KW - Education KW - Adolescents KW - Complications KW - Psychotherapy KW - Etiology KW - Ethics KW - Species diversity KW - Longevity KW - Aetiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40372126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.atitle=Vocational+Rehabilitation+Needs+Assessment+with+Veterans+with+Spinal+Cord+Injury&rft.au=Ottomanelli%2C+Lisa+A&rft.aulast=Ottomanelli&rft.aufirst=Lisa&rft.date=2006-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006AASCIPSWprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spousal Caregiving as Couples Age: Readjustment to Life with Spinal Cord Injury T2 - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AN - 40372091; 4427336 JF - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AU - Penzo, Jeanine A Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 KW - Volatile organic compounds KW - Psychology KW - Reviews KW - Spinal cord injury KW - Experts KW - Pediatrics KW - Life span KW - Sexuality KW - Education KW - Adolescents KW - Complications KW - Psychotherapy KW - Etiology KW - Ethics KW - Species diversity KW - Longevity KW - Aetiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40372091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.atitle=Spousal+Caregiving+as+Couples+Age%3A+Readjustment+to+Life+with+Spinal+Cord+Injury&rft.au=Penzo%2C+Jeanine+A&rft.aulast=Penzo&rft.aufirst=Jeanine&rft.date=2006-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006AASCIPSWprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Follow-Up Aftercare to Wounded Active Duty Military with Spinal Cord Injuries T2 - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AN - 40371911; 4427350 JF - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AU - Lefavor, David E Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 KW - Volatile organic compounds KW - Psychology KW - Reviews KW - Spinal cord injury KW - Experts KW - Pediatrics KW - Life span KW - Sexuality KW - Education KW - Adolescents KW - Complications KW - Psychotherapy KW - Etiology KW - Ethics KW - Species diversity KW - Longevity KW - Aetiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40371911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.atitle=Follow-Up+Aftercare+to+Wounded+Active+Duty+Military+with+Spinal+Cord+Injuries&rft.au=Lefavor%2C+David+E&rft.aulast=Lefavor&rft.aufirst=David&rft.date=2006-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006AASCIPSWprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationships between Pain, Pain Interference, and Depression in People with Spinal Injury T2 - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AN - 40371865; 4427330 JF - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AU - Clark, Heather J Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 KW - Volatile organic compounds KW - Psychology KW - Reviews KW - Spinal cord injury KW - Experts KW - Pediatrics KW - Life span KW - Sexuality KW - Education KW - Adolescents KW - Complications KW - Psychotherapy KW - Etiology KW - Ethics KW - Species diversity KW - Longevity KW - Aetiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40371865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.atitle=Relationships+between+Pain%2C+Pain+Interference%2C+and+Depression+in+People+with+Spinal+Injury&rft.au=Clark%2C+Heather+J&rft.aulast=Clark&rft.aufirst=Heather&rft.date=2006-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006AASCIPSWprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Empirically-Supported Psychological Interventions for Pain and Depression after Spinal Cord Injury: Rationale and Challenges to Implementation T2 - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AN - 40371848; 4427335 JF - 20th Annual Conference of the American Association of Spinal Cord Injury Psychologists and Social Workers (AASCIPSW 2006) AU - Ullrich, Philip M Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 KW - Volatile organic compounds KW - Psychology KW - Reviews KW - Spinal cord injury KW - Experts KW - Pediatrics KW - Life span KW - Sexuality KW - Education KW - Adolescents KW - Complications KW - Psychotherapy KW - Etiology KW - Ethics KW - Species diversity KW - Longevity KW - Aetiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40371848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.atitle=Empirically-Supported+Psychological+Interventions+for+Pain+and+Depression+after+Spinal+Cord+Injury%3A+Rationale+and+Challenges+to+Implementation&rft.au=Ullrich%2C+Philip+M&rft.aulast=Ullrich&rft.aufirst=Philip&rft.date=2006-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Conference+of+the+American+Association+of+Spinal+Cord+Injury+Psychologists+and+Social+Workers+%28AASCIPSW+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://data.unitedspinal.org/2006Programs/2006AASCIPSWprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A platform of high-efficiency nonviral gene transfer in mouse osteoblast cells in vitro AN - 954576209; 13860230 AB - We have previously established mouse genetic models and identified the genetic components of quantitative trait loci (QTL) on mouse chromosomes that contribute to phenotypes such as bone size, bone density, and bone's anabolic response to mechanical loading. However, these regions contain dozens of unknown genes that are needed for functional testing. In this study, we provided a protocol of nucleoporation with high efficiency by using a commercial nucleofection buffer and Gene Pulser to deliver a test gene into bone cells for functional studies. We cloned an osteoblast differentiation-specific geneosterix (Osx) from a mouse bone cDNA library into a pHGCX expression vector and used nucleoporation to deliver pHGCX/Flag-Osx into the nuclei of MC3T3-E1 cells. We then examined the transfection efficiency transgene expression, and function. Our results have demonstrated that nucleoporation can deliver a transgene into MC3T3-E1 osteoblast cells with approx 94% transfection efficiency, and express a functional Flag-Osx fusion protein capable of inducing cell differentiation as measured by an incease in alkaline phosphatase (ALP) activity. Therefore, this experimental system provides a rapid, safe, and efficient cell-based model of high-throughput phenotypic screening to identify candidate genes from physically mapped regions that are important for osteoblast differentiation. JF - Molecular Biotechnology AU - Xing, Weirong AU - Baylink, David AU - Kapoor, Anil AU - Mohan, Subburaman AD - Musculoskeletal Disease Center, JL Pettis Memorial Veterans Administration Medical, 92357, Loma Linda, CA, Subburaman.Mohan@med.va.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 29 EP - 35 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 34 IS - 1 SN - 1073-6085, 1073-6085 KW - Genetics Abstracts; Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Mechanical loading KW - Quantitative trait loci KW - Osteoblastogenesis KW - Transgenes KW - Animal models KW - Bone density KW - Expression vectors KW - Bone KW - Osteoblasts KW - Chromosomes KW - nucleic acids KW - Alkaline phosphatase KW - Transfection KW - Gene transfer KW - Fusion protein KW - Nuclei KW - Biotechnology KW - W 30905:Medical Applications KW - T 2025:Bone and Bone Diseases KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954576209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Biotechnology&rft.atitle=A+platform+of+high-efficiency+nonviral+gene+transfer+in+mouse+osteoblast+cells+in+vitro&rft.au=Xing%2C+Weirong%3BBaylink%2C+David%3BKapoor%2C+Anil%3BMohan%2C+Subburaman&rft.aulast=Xing&rft.aufirst=Weirong&rft.date=2006-09-01&rft.volume=34&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Molecular+Biotechnology&rft.issn=10736085&rft_id=info:doi/10.1385%2FMB%3A34%3A1%3A29 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Mechanical loading; Osteoblastogenesis; Quantitative trait loci; Transgenes; Bone density; Animal models; Bone; Expression vectors; Osteoblasts; Chromosomes; Alkaline phosphatase; nucleic acids; Gene transfer; Transfection; Fusion protein; Nuclei; Biotechnology DO - http://dx.doi.org/10.1385/MB:34:1:29 ER - TY - JOUR T1 - Amplitude-modulated auditory steady-state responses in younger and older listeners. AN - 85397474; pmid-16999253 AB - The primary purpose of this investigation was to determine whether temporal coding in the auditory system was the same for younger and older listeners. Temporal coding was assessed by amplitude-modulated auditory steady-state responses (AM ASSRs) as a physiologic measure of phase-locking capability. The secondary purpose of this study was to determine whether AM ASSRs were related to behavioral speech understanding ability. AM ASSRs showed that the ability of the auditory system to phase lock to a temporally altered signal is dependent on modulation rate, carrier frequency, and age of the listener. Specifically, the interaction of frequency and age showed that younger listeners had more phase locking than old listeners at 500 Hz. The number of phase-locked responses for the 500 Hz carrier frequency was significantly correlated to word-recognition performance. In conclusion, the effect of aging on temporal processing, as measured by phase locking with AM ASSRs, was found for low-frequency stimuli where phase locking in the auditory system should be optimal. The exploration, and use, of electrophysiologic responses to measure auditory timing analysis in humans has the potential to facilitate the understanding of speech perception difficulties in older listeners. JF - Journal of the American Academy of Audiology AU - Leigh-Paffenroth, E D AU - Fowler, Cynthia G AD - Audiology Service, James H. Quillen VA Medical Center, Mountain Home, TN 37684, USA. elizabeth.leigh@med.va.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 582 EP - 597 VL - 17 IS - 8 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Age Factors KW - Aged KW - *Aging: physiology KW - Analysis of Variance KW - *Auditory Threshold: physiology KW - *Evoked Potentials, Auditory: physiology KW - Female KW - Humans KW - Male KW - *Speech Perception: physiology KW - Time Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85397474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Amplitude-modulated+auditory+steady-state+responses+in+younger+and+older+listeners.&rft.au=Leigh-Paffenroth%2C+E+D%3BFowler%2C+Cynthia+G&rft.aulast=Leigh-Paffenroth&rft.aufirst=E&rft.date=2006-09-01&rft.volume=17&rft.issue=8&rft.spage=582&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Frequency-modulation (FM) technology as a method for improving speech perception in noise for individuals with multiple sclerosis. AN - 85395845; pmid-16999255 AB - Almost half of the population with multiple sclerosis (MS) complains of difficulty hearing, despite having essentially normal pure-tone thresholds. The purpose of the present investigation was to evaluate the effects of frequency-modulation (FM) technology utilization on speech perception in noise for adults with and without MS. Sentence material was presented at a constant level of 65 dBA Leq from a loudspeaker located at 0 degrees azimuth. The microphone of the FM transmitter was placed 7.5 cm from this loudspeaker. Multitalker babble was presented from four loudspeakers positioned at 45 degrees, 135 degrees, 225 degrees, and 315 degrees azimuths. The starting presentation level for the babble was 55 dBA Leq, The level of the noise was increased systematically in 1 dB steps until the subject obtained 0% key words correct on the IEEE (Institute for Electrical and Electronic Engineers) sentences. Test results revealed significant differences between the unaided and aided conditions at several signal-to-noise ratios. JF - Journal of the American Academy of Audiology AU - Lewis, M Samantha AU - Hutter, Michele AU - Lilly, David J AU - Bourdette, Dennis AU - Saunders, Julie AU - Fausti, Stephen A AD - VA National Center for Rehabilitative Auditory Research, Portland VAMC, Portland, Oregon 97239, USA. Michele.Lewis3@med.va.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 605 EP - 616 VL - 17 IS - 8 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation KW - Adult KW - Analysis of Variance KW - Audiometry, Pure-Tone KW - Audiometry, Speech KW - Auditory Threshold KW - Case-Control Studies KW - Female KW - *Hearing Aids: classification KW - Hearing Loss: etiology KW - *Hearing Loss: rehabilitation KW - Humans KW - Magnetic Resonance Imaging KW - Male KW - Middle Aged KW - Multiple Sclerosis: complications KW - *Multiple Sclerosis: physiopathology KW - *Noise: adverse effects KW - Radio Waves: classification KW - *Speech Perception: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Frequency-modulation+%28FM%29+technology+as+a+method+for+improving+speech+perception+in+noise+for+individuals+with+multiple+sclerosis.&rft.au=Lewis%2C+M+Samantha%3BHutter%2C+Michele%3BLilly%2C+David+J%3BBourdette%2C+Dennis%3BSaunders%2C+Julie%3BFausti%2C+Stephen+A&rft.aulast=Lewis&rft.aufirst=M&rft.date=2006-09-01&rft.volume=17&rft.issue=8&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Transcranial magnetic stimulation: a possible treatment for TBI. AN - 85394644; pmid-16983227 AB - The purpose of this article is to outline the principles of transcranial magnetic stimulation (TMS), to summarize the existing use of TMS as a prognostic indicator and as a therapeutic device in clinical populations, and to highlight the potential of repetitive TMS (rTMS) as an intervention for traumatic brain injury. TMS is a painless method to stimulate the human brain. Repeated applications of TMS can influence brain plasticity and cortical reorganization through stimulation-induced alterations in neuronal excitability. Existing evidence has demonstrated positive outcomes in people with motor disorders and psychiatric conditions who have received rTMS as a therapeutic intervention. These findings suggest that rTMS may be a promising treatment for people with traumatic brain injury. JF - The Journal of head trauma rehabilitation AU - Pape, Theresa Louise-Bender AU - Rosenow, Joshua AU - Lewis, Gwyn AD - Department of Veterans Affairs (VA), Research Service, Edward Hines Jr. VA Hospital, Hines, IL 60141, USA. Theresa.Pape@va.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 437 EP - 451 VL - 21 IS - 5 SN - 0885-9701, 0885-9701 KW - Index Medicus KW - National Library of Medicine KW - Brain: physiopathology KW - Brain Injuries: diagnosis KW - Brain Injuries: physiopathology KW - *Brain Injuries: rehabilitation KW - Cerebral Cortex: physiopathology KW - Device Approval KW - Equipment Design KW - Equipment Safety KW - Humans KW - Neuronal Plasticity: physiology KW - Recovery of Function: physiology KW - *Transcranial Magnetic Stimulation: instrumentation KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85394644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+head+trauma+rehabilitation&rft.atitle=Transcranial+magnetic+stimulation%3A+a+possible+treatment+for+TBI.&rft.au=Pape%2C+Theresa+Louise-Bender%3BRosenow%2C+Joshua%3BLewis%2C+Gwyn&rft.aulast=Pape&rft.aufirst=Theresa&rft.date=2006-09-01&rft.volume=21&rft.issue=5&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+head+trauma+rehabilitation&rft.issn=08859701&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - National multicenter study of HIV testing and HIV seropositivity in patients with chronic hepatitis C virus infection. AN - 85391805; pmid-16940888 AB - Although HIV testing is recommended for persons with hepatitis C virus (HCV) infection who are at risk for HIV, little is known about HIV testing in this population.Data were prospectively collected in 4364 HCV-infected patients at 24 Veterans Affairs medical centers across the United States, including demographics, risk factors for HIV infection, and self-reported information on HIV testing.Overall, 76.8% had been tested for HIV at least once, 14.8% were never tested, 6.6% did not know if they were tested, and 1.8% declined to answer. Multivariable analysis identified injection drug use, needlestick injury, sex with a same-sex partner, a greater number of lifetime sexual partners, and sex with an injection drug user as factors that were independently associated with HIV testing. At least one risk factor for HIV infection was present in 84.5% of the 646 patients who were never HIV tested. Among the 3350 subjects who were tested for HIV, 8.4% were positive, 88.3% were negative, 2.4% did not know the results of their test, and 0.9% declined to answer. Multivariable analysis identified African American and Hispanic race/ethnicity, income < or = 10,000 dollars, sex with a same-sex partner, and sex with an injection drug user as the only variables that were independently associated with HIV seropositivity.Although a substantial proportion of HCV-infected patients have been tested for HIV, missed opportunities for early diagnosis of HIV infection exist. Public health strategies to improve HIV testing among patients with chronic HCV infection are needed. JF - Journal of clinical gastroenterology AU - Bini, Edmund J AU - Currie, Sue L AU - Shen, Hui AU - Bräu, Norbert AU - Schmidt, Warren AU - Anand, Bhupinderjit S AU - Cheung, Ramsey AU - Wright, Teresa L AD - VA New York Harbor Healthcare System and NYU School of Medicine, New York, NY, USA. Edmund.Bini@med.va.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 732 EP - 739 VL - 40 IS - 8 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - *AIDS Serodiagnosis KW - Adult KW - Aged KW - Female KW - HIV Seropositivity: complications KW - *HIV Seropositivity: diagnosis KW - HIV Seropositivity: epidemiology KW - *Hepatitis C, Chronic: complications KW - Hepatitis C, Chronic: epidemiology KW - Humans KW - Male KW - Middle Aged KW - Predictive Value of Tests KW - Prevalence KW - Risk Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85391805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=National+multicenter+study+of+HIV+testing+and+HIV+seropositivity+in+patients+with+chronic+hepatitis+C+virus+infection.&rft.au=Bini%2C+Edmund+J%3BCurrie%2C+Sue+L%3BShen%2C+Hui%3BBr%C3%A4u%2C+Norbert%3BSchmidt%2C+Warren%3BAnand%2C+Bhupinderjit+S%3BCheung%2C+Ramsey%3BWright%2C+Teresa+L&rft.aulast=Bini&rft.aufirst=Edmund&rft.date=2006-09-01&rft.volume=40&rft.issue=8&rft.spage=732&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Nesiritide: trials and tribulations. AN - 68986258; 17056828 AB - Standard therapy for acute decompensated heart failure, a major health problem, consists of intravenous diuretics, vasodilators, and positive inotropic agents. Nesiritide, a recombinant form of human B-type natriuretic peptide, is the only drug specifically approved for this indication. Recent meta-analyses have reported an increased risk of worsening renal function and 30-day mortality with nesiritide administration. These data understandably require physicians to carefully reevaluate their current use of nesiritide in patients with acute decompensated heart failure. In performing this reevaluation, it is important to consider our understanding of the underlying disease state, the limitations and results of these meta-analyses, and new data that provide additional insight into the possible risks and benefits associated with nesiritide therapy. Until additional therapeutic trials are conducted, therapeutic choices must be based on symptomatic and hemodynamic improvement and limited, imperfect available data, which may continue to support the use of nesiritide for its established indication. JF - Journal of cardiovascular pharmacology and therapeutics AU - Arora, Rohit R AD - Department of Medicine, The Chicago Medical School, Chicago, Illinois, USA. rohit.arora@va.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 165 EP - 169 VL - 11 IS - 3 SN - 1074-2484, 1074-2484 KW - Natriuretic Agents KW - 0 KW - Natriuretic Peptide, Brain KW - 114471-18-0 KW - Creatinine KW - AYI8EX34EU KW - Index Medicus KW - Renal Insufficiency -- blood KW - Acute Disease KW - Randomized Controlled Trials as Topic KW - Renal Insufficiency -- chemically induced KW - Risk Factors KW - Humans KW - Renal Insufficiency -- epidemiology KW - Decision Making KW - Research Design KW - Meta-Analysis as Topic KW - Creatinine -- blood KW - Risk Assessment KW - Natriuretic Peptide, Brain -- therapeutic use KW - Natriuretic Agents -- adverse effects KW - Heart Failure -- mortality KW - Heart Failure -- drug therapy KW - Natriuretic Peptide, Brain -- adverse effects KW - Natriuretic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68986258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.atitle=Nesiritide%3A+trials+and+tribulations.&rft.au=Arora%2C+Rohit+R&rft.aulast=Arora&rft.aufirst=Rohit&rft.date=2006-09-01&rft.volume=11&rft.issue=3&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.issn=10742484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-16 N1 - Date created - 2006-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differences in characteristics and outcome of delirium as based on referral patterns. AN - 68841135; 16959924 AB - The authors studied factors associated with referral of delirium patients to psychiatry consultation and its outcome implications. Characteristics and treatment outcomes of delirium patients referred to psychiatry were compared with those not referred. Referred patients were younger, had a more hyperactive subtype, greater substance abuse, less comorbid dementia, were more likely to be recognized as having delirium, and be prescribed medications. Improvement in referred patients was indicated by lower readmission rate postdischarge. No differences were noted in length of stay, discharge status, or mortality within 1 year of the index episode. Psychiatric interventions were moderately helpful. Patients' characteristics and delirium subtypes may influence referral and should inform future liaison efforts. JF - Psychosomatics AU - Mittal, Dinesh AU - Majithia, Deepika AU - Kennedy, Richard AU - Rhudy, Jamie AD - HSR&D Center for Mental Healthcare and Outcomes Research and Central Arkansas Veterans Healthcare System, Little Rock, AR, 2200 Fort Roots Dr. (152/NLR), North Little Rock, AR 72114, USA. dinesh.mittal@med.va.gov PY - 2006 SP - 367 EP - 375 VL - 47 IS - 5 SN - 0033-3182, 0033-3182 KW - Index Medicus KW - Patient Readmission -- statistics & numerical data KW - Age Factors KW - Patient Discharge -- statistics & numerical data KW - Length of Stay -- statistics & numerical data KW - Dementia -- epidemiology KW - Humans KW - Dementia -- psychology KW - Aged KW - Substance-Related Disorders -- psychology KW - Male KW - Female KW - Comorbidity KW - Substance-Related Disorders -- epidemiology KW - Referral and Consultation -- statistics & numerical data KW - Delirium -- psychology KW - Delirium -- epidemiology KW - Delirium -- therapy KW - Outcome and Process Assessment (Health Care) -- statistics & numerical data KW - Outcome and Process Assessment (Health Care) -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68841135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatics&rft.atitle=Differences+in+characteristics+and+outcome+of+delirium+as+based+on+referral+patterns.&rft.au=Mittal%2C+Dinesh%3BMajithia%2C+Deepika%3BKennedy%2C+Richard%3BRhudy%2C+Jamie&rft.aulast=Mittal&rft.aufirst=Dinesh&rft.date=2006-09-01&rft.volume=47&rft.issue=5&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Psychosomatics&rft.issn=00333182&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-04 N1 - Date created - 2006-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Silicone oil emulsification in the anterior chamber after vitreoretinal surgery. AN - 68806743; 16939886 AB - The use of silicone oil as an endotamponade for the treatment of complicated retinal detachment is common, but long-term complications can occur if the oil is not removed later. This article documents a case of emulsified silicone oil migration into the anterior chamber after vitreoretinal surgery and provides a discussion and review of common anterior segment complications from this condition. A 59-year-old man reported to the eye clinic complaining of a "growth" over his right eye that had increased in size over the last month. Slit lamp examination found a "reverse pseudohypopyon" in the right eye, which was actually emulsified silicone oil that had migrated from the posterior chamber after a previous retinal detachment repair. The patient was referred for surgical removal of this oily obstruction. Although surgical treatment was delayed for 18 months, his vision improved and his intraocular pressure was lowered through surgical and medical management. The use of silicone oil as an endotamponade in cases of complex retinal detachment has become common, but it also may lead to postoperative complications if it is not surgically removed later. This case highlights possible complications from the migration of emulsified silicone oil into the anterior chamber and illustrates the importance of follow-up care for every ophthalmic surgical procedure. JF - Optometry (St. Louis, Mo.) AU - Light, Dennis J AD - Department of Veterans Affairs, Eastern Colorado Health Care System Eye Clinic, Pueblo, Colorado 81008, USA. dennis.light@va.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 446 EP - 449 VL - 77 IS - 9 SN - 1529-1839, 1529-1839 KW - Emulsions KW - 0 KW - Silicone Oils KW - Index Medicus KW - Postoperative Complications KW - Humans KW - Reoperation KW - Middle Aged KW - Follow-Up Studies KW - Injections KW - Male KW - Silicone Oils -- adverse effects KW - Foreign-Body Migration -- surgery KW - Vitrectomy -- methods KW - Silicone Oils -- administration & dosage KW - Foreign-Body Migration -- etiology KW - Foreign-Body Migration -- pathology KW - Retinal Detachment -- surgery KW - Anterior Chamber UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68806743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Optometry+%28St.+Louis%2C+Mo.%29&rft.atitle=Silicone+oil+emulsification+in+the+anterior+chamber+after+vitreoretinal+surgery.&rft.au=Light%2C+Dennis+J&rft.aulast=Light&rft.aufirst=Dennis&rft.date=2006-09-01&rft.volume=77&rft.issue=9&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Optometry+%28St.+Louis%2C+Mo.%29&rft.issn=15291839&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-31 N1 - Date created - 2006-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alzheimer's disease: psychopathology, medical management and dental implications. AN - 68806156; 16946428 AB - The authors review the clinical features, epidemiology, pathophysiology, medical management, dental findings and dental treatment of patients with Alzheimer's disease (AD). The authors conducted MEDLINE searches for 2000 through 2005 using the terms "Alzheimer's disease," "geriatric," "epidemiology," "pathophysiology," "treatment" and "dentistry." Reports selected for further review included those published in English in peer-reviewed journals. The authors gave preference to articles reporting randomized, controlled trials. AD is a progressive and fatal neurodegenerative disorder characterized by cognitive dysfunctions, particularly in learning and memory, and the emergence of behavioral abnormalities. Deficiencies in the cells responsible for storage and processing of information underlie the cognitive, functional and behavioral changes seen in patients with the disorder. As the elderly population grows, increasing numbers of Americans with AD will require dental treatment. The prevalence of dental disease likely will be extensive, because of diminished salivary flow and patients' inability to perform appropriate oral hygiene techniques. Preventive dental education for the caregiver and use of saliva substitutes and anticaries agents by the patient are indicated. JF - Journal of the American Dental Association (1939) AU - Friedlander, Arthur H AU - Norman, Dean C AU - Mahler, Michael E AU - Norman, Keith M AU - Yagiela, John A AD - VA Greater Lost Angeles Healthcare System, Hospital Dental Service, University of California Los Angeles Medical Center, USA. arthur.friedlander@med.va.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1240 EP - 1251 VL - 137 IS - 9 SN - 0002-8177, 0002-8177 KW - Antipsychotic Agents KW - 0 KW - Dopamine Agents KW - Nootropic Agents KW - Dentistry KW - Index Medicus KW - Age of Onset KW - Antipsychotic Agents -- therapeutic use KW - Humans KW - Disease Progression KW - Aged KW - Mouth Diseases -- etiology KW - Dopamine Agents -- therapeutic use KW - Aged, 80 and over KW - Nootropic Agents -- therapeutic use KW - Dopamine Agents -- adverse effects KW - Middle Aged KW - Antipsychotic Agents -- adverse effects KW - Female KW - Male KW - Dental Care for Chronically Ill -- methods KW - Alzheimer Disease -- complications KW - Alzheimer Disease -- drug therapy KW - Alzheimer Disease -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68806156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Alzheimer%27s+disease%3A+psychopathology%2C+medical+management+and+dental+implications.&rft.au=Friedlander%2C+Arthur+H%3BNorman%2C+Dean+C%3BMahler%2C+Michael+E%3BNorman%2C+Keith+M%3BYagiela%2C+John+A&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2006-09-01&rft.volume=137&rft.issue=9&rft.spage=1240&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-26 N1 - Date created - 2006-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Smoking imputation and lung cancer in railroad workers exposed to diesel exhaust. AN - 68787892; 16767725 AB - An association between diesel exhaust exposure and lung cancer mortality in a large retrospective cohort study of US railroad workers has previously been reported. However, specific information regarding cigarette smoking was unavailable. Birth cohort, age, job, and cause of death specific smoking histories from a companion case-control study were used to impute smoking behavior for 39,388 railroad workers who died 1959-1996. Mortality analyses incorporated the effect of smoking on lung cancer risk. The smoking adjusted relative risk of lung cancer in railroad workers exposed to diesel exhaust compared to unexposed workers was 1.22 (95% CI = 1.12-1.32), and unadjusted for smoking the relative risk was 1.35 (95% CI = 1.24-1.46). These analyses illustrate the use of imputation in record-based occupational health studies to assess potential confounding due to smoking. In this cohort, small differences in smoking behavior between diesel exposed and unexposed workers did not explain the elevated lung cancer risk. JF - American journal of industrial medicine AU - Garshick, Eric AU - Laden, Francine AU - Hart, Jaime E AU - Smith, Thomas J AU - Rosner, Bernard AD - Pulmonary and Critical Care Medicine Section, Medical Service, VA Boston Healthcare System, MA 02132, USA. eric.garshick@med.va.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 709 EP - 718 VL - 49 IS - 9 SN - 0271-3586, 0271-3586 KW - Vehicle Emissions KW - 0 KW - Index Medicus KW - Risk Factors KW - Humans KW - Confounding Factors (Epidemiology) KW - Adult KW - Retrospective Studies KW - Case-Control Studies KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Cause of Death KW - Lung Neoplasms -- epidemiology KW - Railroads KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68787892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Smoking+imputation+and+lung+cancer+in+railroad+workers+exposed+to+diesel+exhaust.&rft.au=Garshick%2C+Eric%3BLaden%2C+Francine%3BHart%2C+Jaime+E%3BSmith%2C+Thomas+J%3BRosner%2C+Bernard&rft.aulast=Garshick&rft.aufirst=Eric&rft.date=2006-09-01&rft.volume=49&rft.issue=9&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-07 N1 - Date created - 2006-08-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 1977 Dec;106(6):476-84 [930918] Stat Med. 1991 Apr;10(4):585-98 [2057657] J Occup Med. 1993 Sep;35(9):890-2 [8229339] Epidemiology. 1994 Mar;5(2):189-96 [8172994] Epidemiology. 1995 Jul;6(4):415-8 [7548351] Am J Epidemiol. 1997 Apr 15;145(8):746-51 [9126001] Environ Health Perspect. 2004 Nov;112(15):1539-43 [15531439] Am J Ind Med. 2000 Oct;38(4):399-409 [10982980] Epidemiology. 2002 Jul;13(4):437-44 [12094099] Am J Epidemiol. 2003 Jan 1;157(1):74-84 [12505893] AIHA J (Fairfax, Va). 2002 Sep-Oct;63(5):610-6 [12529916] Appl Occup Environ Hyg. 2003 Jan;18(1):25-34 [12650546] J Occup Environ Med. 2004 Jun;46(6):538-48 [15213515] Eur J Epidemiol. 2004;19(5):417-24 [15233313] Am J Epidemiol. 2004 Aug 15;160(4):384-92 [15286024] Stat Med. 2004 Oct 15;23(19):3077-87 [15351961] Int J Epidemiol. 1975 Mar;4(1):51-4 [1116894] J Toxicol Environ Health. 1980 Sep-Nov;6(5-6):1127-31 [7463507] Am J Epidemiol. 1986 Mar;123(3):481-9 [3946394] Am J Epidemiol. 1987 Jul;126(1):144-6 [3591778] Am Rev Respir Dis. 1987 Jun;135(6):1242-8 [3592400] Am J Ind Med. 1988;13(1):43-58 [3257844] Am J Ind Med. 1988;13(1):5-41 [3344755] Am J Ind Med. 1988;13(3):381-94 [3354586] Am J Ind Med. 1988;13(3):395-404 [3281456] Am Rev Respir Dis. 1988 Apr;137(4):820-5 [3354987] Am J Epidemiol. 1978 Jul;108(1):3-8 [685974] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapeutic alliance and the relationship between motivation and treatment outcomes in patients with alcohol use disorder. AN - 68764041; 16919743 AB - Although motivational readiness to change predicts alcohol use disorder (AUD) treatment outcomes, little is known about treatment aspects that are helpful for patients with low motivation. We examined whether a positive therapeutic alliance is particularly beneficial for patients entering AUD treatment with low motivation. Among Project MATCH outpatients (n = 753), we tested the influence of motivation, therapeutic alliance, and their interaction on 6-month and 1-year alcohol use. The impact of motivation on alcohol use varied depending on therapists' perceptions of alliance. Interactions involving treatment compliance did not mediate the Motivation x Alliance interaction. Thus, a positive therapeutic relationship may be particularly important for patients with low motivation, but mechanisms underlying this possible patient-treatment "match" remain to be determined. JF - Journal of substance abuse treatment AU - Ilgen, Mark A AU - McKellar, John AU - Moos, Rudolf AU - Finney, John W AD - Center for Health Care Evaluation, Department of Veterans Affairs Palo Alto Health Care System, Menlo Park, CA 94025, USA. mark.ilgen@med.va.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 157 EP - 162 VL - 31 IS - 2 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Patient Compliance KW - Humans KW - Treatment Outcome KW - Patient Care Team KW - Motivation KW - Alcoholism -- therapy KW - Cognitive Therapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68764041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Therapeutic+alliance+and+the+relationship+between+motivation+and+treatment+outcomes+in+patients+with+alcohol+use+disorder.&rft.au=Ilgen%2C+Mark+A%3BMcKellar%2C+John%3BMoos%2C+Rudolf%3BFinney%2C+John+W&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2006-09-01&rft.volume=31&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-03 N1 - Date created - 2006-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predictors of engagement in continuing care following residential substance use disorder treatment. AN - 68690033; 16417977 AB - Patients in intensive SUD programs who subsequently participate in continuing care for a longer interval have better outcomes than those who participate for a shorter interval. We sought to identify patient and program factors associated with duration of engagement in SUD continuing care after residential/inpatient treatment. Patients (n=3032) at 15 geographically diverse SUD residential treatment programs provided data on demographics, symptom patterns, recovery resources, and perceptions of treatment environment. We identified patient characteristics associated with the number of consecutive months of engagement in continuing care. We then consolidated and classified risk factors into an integrated model. Being African American, having more SUD and psychiatric symptoms, more resources for recovery, and perceiving the treatment staff as being supportive were associated with longer engagement in continuing care. African Americans' engagement in continuing care was 17% longer than Caucasians'. The positive effect of being African American was partially mediated by having taken actions toward changing use, and by the presence of psychotic symptoms. These results extend previous research on the predictors of continuing care engagement after residential SUD programs. Clinicians can use information about characteristics that put patients at risk for shorter engagement in continuing care to target patients who might benefit from interventions to increase engagement in continuing care. JF - Drug and alcohol dependence AU - Harris, Alex H S AU - McKellar, John D AU - Moos, Rudolf H AU - Schaefer, Jeanne A AU - Cronkite, Ruth C AD - Center for Health Care Evaluation, VA Palo Alto Health Care System, CA, USA. Alexander.HarrisZ@va.gov Y1 - 2006/09/01/ PY - 2006 DA - 2006 Sep 01 SP - 93 EP - 101 VL - 84 IS - 1 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Severity of Illness Index KW - Cognition Disorders -- diagnosis KW - Motivation KW - Cognition Disorders -- epidemiology KW - Humans KW - Mental Disorders -- epidemiology KW - Religion KW - Reinforcement (Psychology) KW - Ethnic Groups -- statistics & numerical data KW - Demography KW - Mental Disorders -- diagnosis KW - Inactivation, Metabolic KW - Suicide, Attempted -- statistics & numerical data KW - Adaptation, Psychological KW - Adult KW - Surveys and Questionnaires KW - Health Behavior KW - Neuropsychological Tests KW - Time Factors KW - Male KW - Prevalence KW - Substance-Related Disorders -- diagnosis KW - Continuity of Patient Care -- statistics & numerical data KW - Residential Treatment KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68690033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Predictors+of+engagement+in+continuing+care+following+residential+substance+use+disorder+treatment.&rft.au=Harris%2C+Alex+H+S%3BMcKellar%2C+John+D%3BMoos%2C+Rudolf+H%3BSchaefer%2C+Jeanne+A%3BCronkite%2C+Ruth+C&rft.aulast=Harris&rft.aufirst=Alex+H&rft.date=2006-09-01&rft.volume=84&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-28 N1 - Date created - 2006-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predictors of outcome for patients with substance-use disorders five years after treatment dropout. AN - 68650869; 16847536 AB - Few studies focus on the outcome of patients after they drop out of substance-use disorder (SUD) treatment, and there appear to be no prior studies of the long-term outcomes of these patients. The aim of this study is to determine how well such patients do after dropping out of treatment and to identify predictors of differential outcomes. Patients in 15 residential SUD treatment programs were assessed at treatment entry and at 5-year follow-up on their frequency and severity of substance use, expectancies and beliefs about substance use, and social resources and stressors. Patients who dropped out and stayed out of treatment (n = 193) were compared with those who completed treatment (n = 3,204). Predictors of 5-year SUD problems among dropouts were identified. In general, dropouts and treatment completers did not differ significantly on their levels of SUD problems at 5 years. At baseline, patients who dropped out reported more involvement in 12-step organizations and greater cognitive impairment and more closely identified with the label "drug addict" than "alcoholic." Lower severity of SUD, lower self-efficacy, fewer positive substance- use expectancies, and less stress from social networks predicted fewer SUD problems at 5 years among dropouts. In addition to focusing on substance use, providers should address the adequacy of patients' social support and counter positive substance-use expectancies at the earliest stages of treatment before patients drop out. JF - Journal of studies on alcohol AU - McKellar, John D AU - Harris, Alexander H AU - Moos, Rudolf H AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, Menlo Park, California 94025, USA. John.McKellar@med.va.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 685 EP - 693 VL - 67 IS - 5 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Demography KW - Culture KW - Prospective Studies KW - Humans KW - Adult KW - Treatment Outcome KW - Surveys and Questionnaires KW - Self Efficacy KW - Follow-Up Studies KW - Male KW - Residential Facilities -- statistics & numerical data KW - Patient Dropouts -- statistics & numerical data KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68650869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Predictors+of+outcome+for+patients+with+substance-use+disorders+five+years+after+treatment+dropout.&rft.au=McKellar%2C+John+D%3BHarris%2C+Alexander+H%3BMoos%2C+Rudolf+H&rft.aulast=McKellar&rft.aufirst=John&rft.date=2006-09-01&rft.volume=67&rft.issue=5&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-19 N1 - Date created - 2006-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prechemotherapy assessment of neutropenic risk. AN - 68396785; 18153977 AB - Chemotherapy-induced febrile neutropenia (FN) predisposes patients to life-threatening infections and typically requires hospitalization. The goal was to investigate whether a risk assessment tool aligned with national guidelines could help identify patients at risk of FN and reduce FN-related hospitalizations. Beginning in October 2004, oncology nurses applied the new risk assessment tool to all patients initiating chemotherapy or a new regimen. Patients at risk for FN received prophylactic colony-stimulating factor. Charts for 189 patients receiving chemotherapy in fiscal year 2005 (FY05) were compared with charts of 155 patients receiving chemotherapy in FY04, before the tool was implemented. The incidence of FN-related hospitalization declined by 78%, from 9.7% in FY04 to 2.1% in FY05 (P = .003). Total hospital days decreased from 117 to 24. Routine systematic evaluation by oncology nurses improves recognition of patients at risk of FN and substantially reduces FN-related hospitalization. JF - Oncology (Williston Park, N.Y.) AU - Doyle, Anne M AD - Puget Sound Veterans Affairs Medical Center, Cancer Care Clinic, Seattle, Washington 98108, USA. Anne.Doyle2@va.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 32 EP - 9; discussion 39-40 VL - 20 IS - 10 Suppl Nurse Ed SN - 0890-9091, 0890-9091 KW - Antineoplastic Agents KW - 0 KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Index Medicus KW - Humans KW - Practice Guidelines as Topic KW - Granulocyte Colony-Stimulating Factor -- administration & dosage KW - Risk Assessment KW - Fever -- chemically induced KW - Neoplasms -- drug therapy KW - Fever -- prevention & control KW - Neoplasms -- nursing KW - Neutropenia -- prevention & control KW - Neutropenia -- chemically induced KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68396785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+%28Williston+Park%2C+N.Y.%29&rft.atitle=Prechemotherapy+assessment+of+neutropenic+risk.&rft.au=Doyle%2C+Anne+M&rft.aulast=Doyle&rft.aufirst=Anne&rft.date=2006-09-01&rft.volume=20&rft.issue=10+Suppl+Nurse+Ed&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Oncology+%28Williston+Park%2C+N.Y.%29&rft.issn=08909091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-15 N1 - Date created - 2007-12-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Technology-based training in cognitive behavioral therapy for substance abuse counselors. AN - 68201741; 17135177 AB - This study compared the learning outcomes achieved by 166 practicing substance abuse counselors who were randomized to one of three conditions: (1) a Web-Based Training (WBT) module designed to familiarize practitioners with the "Coping with Craving" module from the NIDA treatment manual, "A Cognitive-Behavioral Approach: Treating Cocaine Addiction" (www.nidatoolbox.org), (2) a face-to-face training workshop covering the identical content, or (3) a delayed training control condition. Participants in all three conditions completed an identical test of knowledge before and after the session. Results indicated that participants in both the WBT and face-to-face workshop conditions showed improvement in mean test scores, while participants in the delayed training control condition did not. Improvements in test scores for participants in both the WBT and face-to-face conditions were statistically significant and equally modest in magnitude. The finding of equivalent rates of knowledge transfer across these two delivery mechanisms highlight one function for which WBT may be particularly well-suited, and suggest that the most effective clinical training applications may use a "blended delivery" format that leverages the strengths of both WBT and face-to-face training. JF - Substance abuse AU - Weingardt, Kenneth R AU - Villafranca, Steven W AU - Levin, Cindy AD - Center for Health Care Evaluation, VA Palo Alto Health Care System and Stanford University School of Medicine, Palo Alto, CA, USA. ken.weingardt@va.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 19 EP - 25 VL - 27 IS - 3 SN - 0889-7077, 0889-7077 KW - Index Medicus KW - Clinical Competence KW - Education KW - Humans KW - Curriculum KW - Adult KW - Middle Aged KW - Male KW - Female KW - Computer-Assisted Instruction KW - Cognitive Therapy -- education KW - Counseling -- education KW - Cocaine-Related Disorders -- rehabilitation KW - Internet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68201741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=Technology-based+training+in+cognitive+behavioral+therapy+for+substance+abuse+counselors.&rft.au=Weingardt%2C+Kenneth+R%3BVillafranca%2C+Steven+W%3BLevin%2C+Cindy&rft.aulast=Weingardt&rft.aufirst=Kenneth&rft.date=2006-09-01&rft.volume=27&rft.issue=3&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-17 N1 - Date created - 2006-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reliability of Lifetime Drinking History among Alcohol Dependent Men AN - 57067969; 200618179 AB - Information regarding patterns & correlates of problem drinking over the life course is important for both clinical & research purposes although few retrospective, psychometrically adequate instruments to collect data of this kind are available. In the current study, the authors report 5-year test-retest reliabilities of the Lifetime Drinking History (LDH). Analyses were based on 49 male participants with a lifetime diagnosis of alcohol dependence who were residing within intact families & who were not seeking treatment at time of initial assessment. Overall, the LDH was found to reflect adequate stability over this long retest interval for a number of relevant drinking measures, with results providing further support for the instrument's psychometric strengths. Limits on the generalizability of these findings & future research needs are discussed. Tables, References. [Copyright 2006 The American Psychological Association.] JF - Psychology of Addictive Behaviors AU - Jacob, Theodore AU - Seilhamer, Ruth Ann AU - Bargeil, Kay AU - Howell, Donelle N AD - Veterans Administration Palo Alto Health Care System, Menlo Park, CA tjacob@pgsp.edu Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 333 EP - 337 PB - American Psychological Association, Washington DC VL - 20 IS - 3 SN - 0893-164X, 0893-164X KW - lifetime drinking histories, reliability of retrospective self-reports of alcohol use KW - Test-Retest reliability KW - Alcohol dependence KW - Problem drinking KW - Life histories KW - Retrospective studies KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57067969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Addictive+Behaviors&rft.atitle=Reliability+of+Lifetime+Drinking+History+among+Alcohol+Dependent+Men&rft.au=Jacob%2C+Theodore%3BSeilhamer%2C+Ruth+Ann%3BBargeil%2C+Kay%3BHowell%2C+Donelle+N&rft.aulast=Jacob&rft.aufirst=Theodore&rft.date=2006-09-01&rft.volume=20&rft.issue=3&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/10.1037%2F0893-164X.20.3.333 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-29 N1 - Last updated - 2016-09-27 N1 - CODEN - PABEEI N1 - SubjectsTermNotLitGenreText - Retrospective studies; Alcohol dependence; Life histories; Problem drinking; Test-Retest reliability DO - http://dx.doi.org/10.1037/0893-164X.20.3.333 ER - TY - JOUR T1 - Neurotrophin-3 Gradients Established by Lentiviral Gene Delivery Promote Short-Distance Axonal Bridging beyond Cellular Grafts in the Injured Spinal Cord AN - 20854813; 7063191 AB - Neurotrophic factor delivery to sites of spinal cord injury (SCI) promotes axon growth into but not beyond lesion sites. We tested the hypothesis that sustained growth factor gradients beyond regions of SCI will promote significant axonal bridging into and beyond lesions. Adult rats underwent C3 lesions to transect ascending dorsal column sensory axons, and autologous bone marrow stromal cells were grafted into the lesion to provide a cellular bridge for growth into the injured region. Concurrently, lentiviral vectors expressing neurotrophin-3 (NT-3) or green fluorescent protein (GFP) (controls) were injected into the host cord rostral to the lesion to promote axon extension beyond the graft/lesion. Four weeks later, NT-3 gradients beyond the lesion were detectable by ELISA in animals that received NT-3-expressing lentiviral vectors, with highest average NT-3 levels located near the rostral vector injection site. Significantly more ascending sensory axons extended into tissue rostral to the lesion site in animals injected with NT-3 vectors compared with GFP vectors, but only if the zone of NT-3 vector transduction extended continuously from the injection site to the graft; any "gap" in NT-3 expression from the graft to rostral tissue resulted in axon bridging failure. Despite axon bridging beyond the lesion, regenerating axons did not continue to grow over very long distances, even in the presence of a continuing growth factor gradient beyond the lesion. These findings indicate that a localized and continuous gradient of NT-3 can achieve axonal bridging beyond the glial scar, but growth for longer distances is not sustainable simply with a trophic stimulus. JF - Journal of Neuroscience AU - Taylor, Laura AU - Jones, Leonard AU - Tuszynski, Mark H AU - Blesch, Armin AD - Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, and Veterans Administration Medical Center, San Diego, California 92165 Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 9713 EP - 9721 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 26 IS - 38 SN - 0270-6474, 0270-6474 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Autografts KW - Enzyme-linked immunosorbent assay KW - stromal cells KW - Sensory neurons KW - Neurotrophic factors KW - Bone marrow KW - Green fluorescent protein KW - Spinal cord injury KW - Expression vectors KW - Nervous system KW - Gene transfer KW - Dorsal columns KW - Allografts KW - Axonogenesis KW - Axons KW - Growth factors KW - Neurotrophin 3 KW - W 30905:Medical Applications KW - G 07880:Human Genetics KW - N3 11057:Neural transplantation and regeneration KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20854813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Neurotrophin-3+Gradients+Established+by+Lentiviral+Gene+Delivery+Promote+Short-Distance+Axonal+Bridging+beyond+Cellular+Grafts+in+the+Injured+Spinal+Cord&rft.au=Taylor%2C+Laura%3BJones%2C+Leonard%3BTuszynski%2C+Mark+H%3BBlesch%2C+Armin&rft.aulast=Taylor&rft.aufirst=Laura&rft.date=2006-09-01&rft.volume=26&rft.issue=38&rft.spage=9713&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Autografts; Enzyme-linked immunosorbent assay; Sensory neurons; stromal cells; Neurotrophic factors; Green fluorescent protein; Bone marrow; Spinal cord injury; Expression vectors; Nervous system; Dorsal columns; Gene transfer; Allografts; Axonogenesis; Axons; Neurotrophin 3; Growth factors ER - TY - JOUR T1 - Efflux Pump Overexpression in Multiple-Antibiotic-Resistant Mutants of Bacteroides fragilis AN - 19989137; 7056971 AB - Multidrug-resistant mutants of a wild-type Bacteroides fragilis strain (strain ADB77) and a quadruple resistance nodulation division family efflux pump deletion mutant (ADB77 Delta bmeB1 Delta bmeB3 Delta bmeB12 Delta bmeB15) were selected with antimicrobials. Ampicillin, doripenem, imipenem, levofloxacin, and metronidazole selected for mutants from both strains; cefoxitin selected for mutants from strain ADB77 only; and sodium dodecyl sulfate selected mutants from ADB77 Delta bmeB1 Delta bmeB3 Delta bmeB12 Delta bmeB15 only. The mutants overexpressed one or more efflux pumps. JF - Antimicrobial Agents & Chemotherapy AU - Pumbwe, Lilian AU - Glass, Daniel AU - Wexler, Hannah M AD - Greater Los Angeles Veterans Administration Healthcare Systems. Department of Medicine, University of California, Los Angeles, Los Angeles, California Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 3150 EP - 3153 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 9 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Bacteroides fragilis KW - Metronidazole KW - Deletion mutant KW - Levofloxacin KW - Drug resistance KW - Nodulation KW - Ampicillin KW - Cefoxitin KW - Imipenem KW - Sulfate KW - Antimicrobial agents KW - J 02310:Genetics & Taxonomy KW - A 01400:Soil Microbes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19989137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Efflux+Pump+Overexpression+in+Multiple-Antibiotic-Resistant+Mutants+of+Bacteroides+fragilis&rft.au=Pumbwe%2C+Lilian%3BGlass%2C+Daniel%3BWexler%2C+Hannah+M&rft.aulast=Pumbwe&rft.aufirst=Lilian&rft.date=2006-09-01&rft.volume=50&rft.issue=9&rft.spage=3150&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Metronidazole; Deletion mutant; Drug resistance; Levofloxacin; Ampicillin; Nodulation; Cefoxitin; Antimicrobial agents; Sulfate; Imipenem; Bacteroides fragilis ER - TY - JOUR T1 - The microbiology of bacteriuria in men: a 5-year study at a Veterans Affairs hospital AN - 19964568; 7044374 AB - Bacteriuria and urinary tract infection occur relatively frequently in older men, but data regarding the causative microorganisms are limited. We retrospectively identified all positive cultures of urine specimens (n = 4943) obtained over a 5-year period at our institution. We determined the frequency of causative microorganisms and grouped these by Gram type, setting of patient care, and method of urine specimen collection. We also assessed the performance characteristics of the Gram-stained smear of uncentrifuged urine. Among our patients, Gram-positive cocci (GPC) were isolated as often as Gram- negative rods (GNR). Escherichia coli was the single or predominant isolate in only 14% of cases, and Enterococcus was the single most commonly identified genus (22.5%). The Gram stain was accurate in predicting the culture results (positive likelihood ratio, 7.0 for GPC and 8.1 for GNR). We conclude that the microorganisms causing bacteriuria in older male veterans are substantially different from those found in women, and the Gram-stained smear provides useful information on the causative organisms. JF - Diagnostic Microbiology and Infectious Disease AU - Cornia, Paul B AU - Takahashi, Traci A AU - Lipsky, Benjamin A AD - Primary and Specialty Medicine Service, Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, WA 98108- 1597, USA, paul.cornia@med.va.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 25 EP - 30 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 56 IS - 1 SN - 0732-8893, 0732-8893 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Urinary tract infection KW - Male KW - Veterans KW - Bacteriuria KW - Uropathogens KW - Gram-stained smear KW - Microbiology KW - Data processing KW - Urinary tract KW - Infection KW - Gram stain KW - Urine KW - Enterococcus KW - Escherichia coli KW - Microorganisms KW - Gram-positive cocci KW - Rods KW - Hospitals KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19964568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+Microbiology+and+Infectious+Disease&rft.atitle=The+microbiology+of+bacteriuria+in+men%3A+a+5-year+study+at+a+Veterans+Affairs+hospital&rft.au=Cornia%2C+Paul+B%3BTakahashi%2C+Traci+A%3BLipsky%2C+Benjamin+A&rft.aulast=Cornia&rft.aufirst=Paul&rft.date=2006-09-01&rft.volume=56&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Diagnostic+Microbiology+and+Infectious+Disease&rft.issn=07328893&rft_id=info:doi/10.1016%2Fj.diagmicrobio.2006.03.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Gram stain; Urine; Microorganisms; Gram-positive cocci; Urinary tract; Infection; Bacteriuria; Rods; Hospitals; Enterococcus; Escherichia coli DO - http://dx.doi.org/10.1016/j.diagmicrobio.2006.03.008 ER - TY - JOUR T1 - The Burden of Obesity Among a National Probability Sample of Veterans AN - 19477690; 6983101 AB - BACKGROUND: Few national data exist about the prevalence of obesity and the resulting health burden among veterans. METHODS: We analyzed data from the 2003 Behavioral Risk Factor Surveillance System (n=242,362) to compare rates of obesity among veterans who do and do not utilize the VA, compared with nonveterans. We used bivariate analyses to describe the association of obesity with lifestyle factors, disability, and comorbid disease, and multivariate analysis to assess the independent association of obesity with VA care. RESULTS: Veterans who use the VA for health care have the highest rates of obesity compared with veterans who do not use the VA and nonveterans (27.7% vs 23.9% vs 22.8%, P<.001). Only 27.8% of veterans who receive health care at the VA are of normal weight (vs 42.6% of the general population, P<.001), 44.5% are overweight, 19.9% have class I obesity, 6% have class II obesity, and 1.8% are morbidly obese (an estimated 82,950 individuals). Obese veterans who utilize the VA for services have higher rates of hypertension (65.8%) and diabetes (31.3%), are less likely to follow diet and exercise guidelines, and more likely to report poor health and disability than their normal-weight counterparts. CONCLUSIONS: Veterans who receive care at the VA have higher rates of overweight and obesity than the general population. At present, less than half of VA medical centers have weight management programs. As the largest integrated U.S. health system, the VA has a unique opportunity to respond to the epidemic of obesity. JF - Journal of General Internal Medicine AU - Nelson, Karin M AD - Dr. Nelson: 1660 South Columbian Way, S-111-GIMC, Seattle, WA 98108-1597, Karin.Nelson@va.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 915 EP - 919 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 21 IS - 9 SN - 0884-8734, 0884-8734 KW - Physical Education Index KW - Handicapped KW - Obesity KW - Programs KW - Weight control KW - Diet (weight control) KW - Health KW - Exercise KW - Diabetes KW - Lifestyle KW - Risk factors KW - Analysis KW - Diseases KW - Hypertension KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19477690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+General+Internal+Medicine&rft.atitle=The+Burden+of+Obesity+Among+a+National+Probability+Sample+of+Veterans&rft.au=Nelson%2C+Karin+M&rft.aulast=Nelson&rft.aufirst=Karin&rft.date=2006-09-01&rft.volume=21&rft.issue=9&rft.spage=915&rft.isbn=&rft.btitle=&rft.title=Journal+of+General+Internal+Medicine&rft.issn=08848734&rft_id=info:doi/10.1111%2Fj.1525-1497.2006.00526.x LA - English DB - Physical Education Index N1 - Date revised - 2007-06-01 N1 - SuppNotes - Tables, 3; references, 43. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Obesity; Handicapped; Programs; Weight control; Diet (weight control); Health; Exercise; Lifestyle; Diabetes; Analysis; Risk factors; Diseases; Hypertension DO - http://dx.doi.org/10.1111/j.1525-1497.2006.00526.x ER - TY - JOUR T1 - Clinical significance of overexpression of multiple RND-family efflux pumps in Bacteroides fragilis isolates AN - 19365143; 7131474 AB - OBJECTIVES: The aim of the present study was to determine correlation between bmeB efflux pump overexpression and resistance to fluoroquinolones and {szligbeta}-lactams in Bacteroides fragilis clinical isolates (n = 51) and the effects of broad-spectrum efflux pump inhibitors (EPIs) on the MICs of the test antibiotics. METHODS: Susceptibility to garenoxacin, levofloxacin, moxifloxacin, cefoxitin and faropenem plus or minus EPIs (CCCP, MC-207,110, reserpine and verapamil) was determined. Expression of bmeB efflux pumps was measured, topoisomerase genes were sequenced and {szligbeta}-lactamase production was determined. RESULTS: Isolates were grouped into categories based on susceptibility patterns, topoisomerase sequence and efflux pump expression. Panel I isolates (19/51, 37.3%) were highly resistant to fluoroquinolones and cefoxitin (resistance to all agents was significantly reduced by EPIs, P < 0.05), had a point mutation in gyrA (C arrow right T) causing a Ser-82 arrow right Phe substitution, and overexpressed bmeB4 and bmeB15. Panel II isolates (7/51; 13.7%) had intermediate-level resistance to fluoroquinolones and cefoxitin and a GyrA substitution. Panel IIIA isolates (21/51; 41.2%) had intermediate-level fluoroquinolone resistance and high-level cefoxitin resistance [resistance to all agents was significantly reduced by EPIs (P < 0.05)] and overexpressed bmeB4 and bmeB15. Panel IIIB isolates (4/51; 7.8%) had low-level fluoroquinolone resistance and high-level resistance to cefoxitin [cefoxitin resistance was significantly reduced by EPIs (P < 0.05)] and overexpressed bmeB4, bmeB6, bmeB10 and bmeB14. All isolates were {szligbeta}-lactamase-positive. CONCLUSIONS: These data suggest that bmeB efflux pump overexpression can (i) cause low- to intermediate-level clinically relevant fluoroquinolone resistance; (ii) be coupled with GyrA substitutions to cause high-level fluoroquinolone resistance; (iii) contribute to high-level clinically relevant resistance to {szligbeta}-lactams. JF - Journal of Antimicrobial Chemotherapy AU - Pumbwe, Lilian AU - Chang, Abraham AU - Smith, Rachel L AU - Wexler, Hannah M AD - Greater Los Angeles Veterans Administration Healthcare Systems 691/151J, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA. Department of Medicine, University of California Los Angeles, CA 90024, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 543 EP - 548 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 58 IS - 3 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Bacteroides fragilis KW - Fluoroquinolones KW - Reserpine KW - Levofloxacin KW - Point mutation KW - garenoxacin KW - Antibiotics KW - Minimum inhibitory concentration KW - Verapamil KW - Moxifloxacin KW - Cefoxitin KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19365143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Clinical+significance+of+overexpression+of+multiple+RND-family+efflux+pumps+in+Bacteroides+fragilis+isolates&rft.au=Pumbwe%2C+Lilian%3BChang%2C+Abraham%3BSmith%2C+Rachel+L%3BWexler%2C+Hannah+M&rft.aulast=Pumbwe&rft.aufirst=Lilian&rft.date=2006-09-01&rft.volume=58&rft.issue=3&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Verapamil; Reserpine; Fluoroquinolones; Moxifloxacin; Levofloxacin; Point mutation; garenoxacin; Antibiotics; Minimum inhibitory concentration; Cefoxitin; Bacteroides fragilis ER - TY - JOUR T1 - Hip-Hop to Health Jr. for Latino Preschool Children AN - 19357551; 7125858 AB - OBJECTIVE: Hip-Hop to Health Jr. was a diet/physical activity intervention designed to reduce gains in BMI (kilograms per meter squared) in preschool minority children. RESEARCH METHODS AND PROCEDURES: Twelve predominantly Latino Head Start centers participated in a group-randomized trial conducted between Fall 2001 and Winter 2003. Six centers were randomized to a culturally proficient 14-week (three times weekly) diet/physical activity intervention. Parents participated by completing weekly homework assignments. The children in the other six centers received a general health intervention that did not address either diet or physical activity. The primary outcome was change in BMI, and secondary outcomes were changes in dietary intake and physical activity. Measures were collected at baseline, post-intervention, and at Years 1 and 2 follow-up. RESULTS: There were no significant differences between intervention and control schools in either primary or secondary outcomes at post-intervention, Year 1, or Year 2 follow-ups. DISCUSSION: When Hip-Hop to Health Jr. was conducted in predominantly black Head Start centers, it was effective in reducing subsequent increases in BMI in preschool children. In contrast, when the program was conducted in Latino centers, it was not effective. Although the intervention did not prevent excessive weight gain in Latino children, it was very well received. Future interventions with this population may require further cultural tailoring and a more robust parent intervention. JF - Obesity Research AU - Fitzgibbon, Marian L AU - Stolley, Melinda R AU - Schiffer, Linda AU - Van Horn, Linda AU - KauferChristoffel, Katherine AU - Dyer, Alan AD - Department of Medicine, Institute for Health Research and Policy, University of Illinois, Chicago, Illinois. Veterans Administration Midwest Center for Health Services and Policy Research and the Jesse Brown Veterans Administration Medical Center, Chicago, Illinois. Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Children's Memorial Hospital, Chicago, Illinois Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1616 EP - 1625 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 14 IS - 9 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Obesity KW - Programs KW - Schools KW - Preventive health KW - Blacks KW - Minorities KW - Diet (weight control) KW - Preschool children KW - Exercise KW - Children KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19357551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Hip-Hop+to+Health+Jr.+for+Latino+Preschool+Children&rft.au=Fitzgibbon%2C+Marian+L%3BStolley%2C+Melinda+R%3BSchiffer%2C+Linda%3BVan+Horn%2C+Linda%3BKauferChristoffel%2C+Katherine%3BDyer%2C+Alan&rft.aulast=Fitzgibbon&rft.aufirst=Marian&rft.date=2006-09-01&rft.volume=14&rft.issue=9&rft.spage=1616&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Obesity; Programs; Schools; Minorities; Blacks; Preventive health; Diet (weight control); Preschool children; Exercise; Children ER - TY - JOUR T1 - Posttraumatic stress disorder in disaster relief workers following direct and indirect trauma exposure to Ground Zero. AN - 68815002; 16929511 AB - The present study compared rates of posttraumatic stress disorder (PTSD) in relief workers at the World Trade Center collapse from two sources: direct exposure to the disaster site and indirect exposure through survivor narratives. Standardized clinical interviews for PTSD were conducted with 109 relief workers 6-8 months after the September 11th terrorist attacks. Rates of acute PTSD from direct and indirect exposure to traumatic stressors were 6.4% and 4.6%, respectively. The findings suggest that indirect exposures can lead to PTSD even when Criterion A1 of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-Text Revision (DSM-IV-TR; American Psychiatric Association, 2000, p. 463), i.e., "experienced by a family member or other close associate" is not met. Further research is necessary to define precisely the parameters of indirect traumatic exposure that may be linked to the development of PTSD. JF - Journal of traumatic stress AU - Zimering, Rose AU - Gulliver, Suzy B AU - Knight, Jeffrey AU - Munroe, James AU - Keane, Terence M AD - VA Boston Healthcare System, Boston, MA and Department of Psychiatry, Boston University School of Medicine, Boston, MA 02114, USA. rose.zimering@va.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 553 EP - 557 VL - 19 IS - 4 SN - 0894-9867, 0894-9867 KW - Index Medicus KW - New York City -- epidemiology KW - Humans KW - Adult KW - Male KW - Female KW - Prevalence KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Health Personnel -- psychology KW - Stress Disorders, Post-Traumatic -- psychology KW - Terrorism -- psychology KW - Relief Work KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68815002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+traumatic+stress&rft.atitle=Posttraumatic+stress+disorder+in+disaster+relief+workers+following+direct+and+indirect+trauma+exposure+to+Ground+Zero.&rft.au=Zimering%2C+Rose%3BGulliver%2C+Suzy+B%3BKnight%2C+Jeffrey%3BMunroe%2C+James%3BKeane%2C+Terence+M&rft.aulast=Zimering&rft.aufirst=Rose&rft.date=2006-08-01&rft.volume=19&rft.issue=4&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Journal+of+traumatic+stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-15 N1 - Date created - 2006-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fear and avoidance of internal experiences among patients with substance use disorders and PTSD: the centrality of anxiety sensitivity. AN - 68809724; 16929503 AB - This study evaluated anxiety sensitivity, cognitive avoidance, and alexithymia and their relationship to posttraumatic stress disorder (PTSD) and alcohol use indices concurrently and prospectively in an outpatient substance abuse treatment sample that screened positive for PTSD (N=58). Anxiety sensitivity accounted for substantial variance in the PTSD clusters, reexperiencing, avoidance, and hyperarousal, both concurrently and prospectively. Cognitive avoidance accounted for additional variance with concurrent PTSD avoidance symptoms. Anxiety sensitivity and cognitive avoidance were largely not associated with alcohol use indices. Alexithymia was largely redundant with cognitive avoidance and was, therefore, not included in the regression analyses. Theoretical and treatment implications of these findings are discussed in the context of individuals with dually diagnosed PTSD and substance abuse disorders. JF - Journal of traumatic stress AU - Simpson, Tracy AU - Jakupcak, Matthew AU - Luterek, Jane A AD - VA Puget Sound Health Care System, Seattle Division, and the Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98108, USA. Tracy.Simpson@va.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 481 EP - 491 VL - 19 IS - 4 SN - 0894-9867, 0894-9867 KW - Index Medicus KW - Washington -- epidemiology KW - Fear KW - Humans KW - Adult KW - Veterans -- psychology KW - Middle Aged KW - Avoidance Learning KW - Male KW - Female KW - Comorbidity KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Anxiety -- psychology KW - Alcoholism -- epidemiology KW - Stress Disorders, Post-Traumatic -- psychology KW - Affective Symptoms -- psychology KW - Alcoholism -- psychology KW - Defense Mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68809724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+traumatic+stress&rft.atitle=Fear+and+avoidance+of+internal+experiences+among+patients+with+substance+use+disorders+and+PTSD%3A+the+centrality+of+anxiety+sensitivity.&rft.au=Simpson%2C+Tracy%3BJakupcak%2C+Matthew%3BLuterek%2C+Jane+A&rft.aulast=Simpson&rft.aufirst=Tracy&rft.date=2006-08-01&rft.volume=19&rft.issue=4&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Journal+of+traumatic+stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-15 N1 - Date created - 2006-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The art of prescribing. Risks and benefits of non-benzodiazepine receptor agonists in the treatment of acute primary insomnia in older adults. AN - 68760544; 16916422 JF - Perspectives in psychiatric care AU - Antai-Otong, Deborah AD - deborah.antai-otong@med.va.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 196 EP - 200 VL - 42 IS - 3 SN - 0031-5990, 0031-5990 KW - Acetamides KW - 0 KW - Azabicyclo Compounds KW - GABA Agonists KW - Hypnotics and Sedatives KW - Piperazines KW - Pyridines KW - Pyrimidines KW - zopiclone KW - 03A5ORL08Q KW - Benzodiazepines KW - 12794-10-4 KW - zolpidem KW - 7K383OQI23 KW - zaleplon KW - S62U433RMH KW - Nursing KW - Causality KW - Acute Disease KW - Professional Autonomy KW - Pyrimidines -- therapeutic use KW - Nursing Assessment KW - Benzodiazepines -- adverse effects KW - Piperazines -- therapeutic use KW - Humans KW - Pyridines -- therapeutic use KW - Acetamides -- therapeutic use KW - Prevalence KW - Hypnotics and Sedatives -- therapeutic use KW - Sleep Initiation and Maintenance Disorders -- drug therapy KW - GABA Agonists -- therapeutic use KW - Sleep Initiation and Maintenance Disorders -- diagnosis KW - Psychiatric Nursing -- organization & administration KW - Hypnotics and Sedatives -- adverse effects KW - Sleep Initiation and Maintenance Disorders -- etiology KW - Patient Selection KW - Drug Prescriptions KW - Sleep Initiation and Maintenance Disorders -- epidemiology KW - GABA Agonists -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68760544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+psychiatric+care&rft.atitle=The+art+of+prescribing.+Risks+and+benefits+of+non-benzodiazepine+receptor+agonists+in+the+treatment+of+acute+primary+insomnia+in+older+adults.&rft.au=Antai-Otong%2C+Deborah&rft.aulast=Antai-Otong&rft.aufirst=Deborah&rft.date=2006-08-01&rft.volume=42&rft.issue=3&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+psychiatric+care&rft.issn=00315990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-12 N1 - Date created - 2006-08-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Iodinated contrast induced renal vasoconstriction is due in part to the downregulation of renal cortical and medullary nitric oxide synthesis. AN - 68720237; 16890873 AB - The loss of renal function continues to be a frequent complication of the iodinated contrast agents used to perform diagnostic angiography and endovascular procedures. This study examined the hypothesis that contrast-induced renal injury is partly due to a decrease in cortical and medullary microvascular blood flow after the downregulation of endogenous renal cortical and medullary nitric oxide (NO) synthesis. Anesthetized male Sprague-Dawley rats (300 g) had microdialysis probes or laser Doppler fibers inserted into the renal cortex to a depth of 2 mm and into the renal medulla to a depth of 4 mm. Laser Doppler blood flow was continuously monitored, and the microdialysis probes were connected to a syringe pump and perfused in vivo at 3 muL/min with lactated Ringer's solution. Dialysate fluid was collected at time zero (basal) and 60 minutes after infusion of either saline or Conray 400 (6 mL/kg). Both groups were treated with saline carrier, N(omega)-nitro-L-arginine methyl ester hydrochloride (L-NAME, 30 mg/kg), L-arginine (400 mg/kg), or superoxide dismutase (10,000 U/kg), an oxygen-derived free radical scavenger. Dialysate was analyzed for total NO and eicosanoid synthesis. The renal cortex and medulla were analyzed for inducible NO synthase (iNOS), cyclooxygenase-2 (COX2), prostacyclin synthase, and prostaglandin E(2) (PGE(2)) synthase content by Western blot analysis. Conray caused a marked decrease in cortical and medullary blood flow with a concomitant decrease in endogenous cortical NO, PGE(2), and medullary NO synthesis. The addition of L-NAME to the Conray further decreased cortical and medullary blood flow and NO synthesis, which were restored toward control by L-arginine. Neither L-NAME nor L-arginine (added to the Conray) altered cortical or medullary eicosanoids release. Medullary PGE(2) synthesis decreased when superoxide dismutase was added to the Conray treatment, suggesting that oxygen-derived free radicals had a protective role in maintaining endogenous medullary PGE(2) synthesis after Conray treatment. Conray did not significantly alter iNOS, COX-2, prostacyclin synthase, or PGE(2) synthase content. These findings suggest that the downregulation of renal cortical and medullary NO synthesis contributes to the contrast-induced loss of renal cortical and medullary microvascular blood flow. Preservation of normal levels of renal cortical and medullary NO synthesis may help prevent or lessen contrast-induced renal vasoconstriction and lessen contrast-induced renal injury found after diagnostic and therapeutic endovascular procedures. JF - Journal of vascular surgery AU - Myers, Stuart I AU - Wang, Li AU - Liu, Fang AU - Bartula, Lori L AD - McGuire Research Institute/McGuire Veterans Administration Medical Center and Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA. simyers1951@aol.com Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 383 EP - 391 VL - 44 IS - 2 SN - 0741-5214, 0741-5214 KW - Contrast Media KW - 0 KW - Enzyme Inhibitors KW - Iothalamic Acid KW - 16CHD79MIX KW - Nitric Oxide KW - 31C4KY9ESH KW - Arginine KW - 94ZLA3W45F KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Dinoprostone KW - K7Q1JQR04M KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - NG-Nitroarginine Methyl Ester -- pharmacology KW - Superoxide Dismutase -- pharmacology KW - Renal Circulation -- drug effects KW - Nitric Oxide Synthase -- antagonists & inhibitors KW - Dinoprostone -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Nitric Oxide Synthase -- metabolism KW - Male KW - Arginine -- pharmacology KW - Kidney Medulla -- blood supply KW - Kidney Cortex -- drug effects KW - Kidney Cortex -- blood supply KW - Iothalamic Acid -- toxicity KW - Kidney Medulla -- metabolism KW - Kidney Medulla -- drug effects KW - Contrast Media -- toxicity KW - Nitric Oxide -- metabolism KW - Vasoconstriction KW - Nitric Oxide -- biosynthesis KW - Kidney Cortex -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68720237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+vascular+surgery&rft.atitle=Iodinated+contrast+induced+renal+vasoconstriction+is+due+in+part+to+the+downregulation+of+renal+cortical+and+medullary+nitric+oxide+synthesis.&rft.au=Myers%2C+Stuart+I%3BWang%2C+Li%3BLiu%2C+Fang%3BBartula%2C+Lori+L&rft.aulast=Myers&rft.aufirst=Stuart&rft.date=2006-08-01&rft.volume=44&rft.issue=2&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Journal+of+vascular+surgery&rft.issn=07415214&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-18 N1 - Date created - 2006-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials. AN - 68712353; 16887404 AB - We performed a systematic review to define the relative and absolute risk of clinically relevant adverse events with the antiplatelet agents, aspirin and clopidogrel. Databases were searched for randomized controlled trials of low-dose aspirin (75-325 mg/day) or clopidogrel administered for cardiovascular prophylaxis. Relative risks (RR) were determined by meta-analysis of 22 trials for aspirin versus placebo and from single studies for aspirin versus clopidogrel, aspirin versus aspirin/clopidogrel, and clopidogrel versus aspirin/clopidogrel. Absolute risk increase was calculated by multiplying RR increase by the pooled weighted incidence of the control. Aspirin increased the risk of major bleeding (RR=1.71; 95% confidence interval [CI], 1.41-2.08), major gastrointestinal (GI) bleeding (RR=2.07; 95% CI, 1.61-2.66), and intracranial bleeding (RR=1.65; 95% CI, 1.06-5.99) versus placebo. No difference between 75-162.5 mg/day and >162.5-325 mg/day aspirin versus placebo was seen. The absolute annual increases attributable to aspirin were major bleeding: 0.13% (95% CI, 0.08-0.20); major GI bleeding: 0.12% (95% CI, 0.07-0.19), intracranial bleeding: 0.03% (95% CI, 0.01-0.08). No study compared clopidogrel with placebo. One study showed increased major GI bleeding (but not non-GI bleeding endpoints) with aspirin versus clopidogrel (RR=1.45; 95% CI, 1.00-2.10). The absolute annual increase was 0.12% (95% CI, 0.00-0.28). Low-dose aspirin increases the risk of major bleeding by approximately 70%, but the absolute increase is modest: 769 patients (95% CI, 500-1250) need to be treated with aspirin to cause one additional major bleeding episode annually. Compared with clopidogrel, aspirin increases the risk of GI bleeding but not other bleeding; however, 883 patients (95% CI, 357-infinity) would need to be treated with clopidogrel versus aspirin to prevent one major GI bleeding episode annually at a cost of over 1 million dollars. JF - The American journal of medicine AU - McQuaid, Kenneth R AU - Laine, Loren AD - Veterans Affairs Medical Center, San Francisco, Ca 94121, USA. enneth.mcquaid@med.va.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 624 EP - 638 VL - 119 IS - 8 KW - Platelet Aggregation Inhibitors KW - 0 KW - clopidogrel KW - A74586SNO7 KW - Ticlopidine KW - OM90ZUW7M1 KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Ticlopidine -- economics KW - Platelet Aggregation Inhibitors -- adverse effects KW - Ticlopidine -- analogs & derivatives KW - Aspirin -- adverse effects KW - Aspirin -- administration & dosage KW - Aspirin -- economics KW - Ticlopidine -- adverse effects KW - Platelet Aggregation Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68712353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Systematic+review+and+meta-analysis+of+adverse+events+of+low-dose+aspirin+and+clopidogrel+in+randomized+controlled+trials.&rft.au=McQuaid%2C+Kenneth+R%3BLaine%2C+Loren&rft.aulast=McQuaid&rft.aufirst=Kenneth&rft.date=2006-08-01&rft.volume=119&rft.issue=8&rft.spage=624&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=1555-7162&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-05 N1 - Date created - 2006-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Health and well being of substance use disorder patients with and without posttraumatic stress disorder. AN - 68689537; 16380217 AB - While studies link posttraumatic stress disorder (PTSD) to substance use disorders (SUDs), little is known about the health and functional status of patients with such comorbidity. This study examined the health and well being of SUD patients with and without PTSD. Participants were assessed using structured clinical interviews and self-administered questionnaires assessing chronic physical symptoms, and functional status and well being. PTSD was significantly associated with more cardiovascular, neurological, and total chronic physical symptoms. In addition, PTSD was significantly related to poorer functional status and well being, particularly in the mental health realm of functioning. The association between PTSD and mental health component of functional health and well-being remained significant after controlling for chronic physical symptoms and other comorbid psychopathology. JF - Addictive behaviors AU - Ouimette, Paige AU - Goodwin, Elizabeth AU - Brown, Pamela J AD - Center for Integrated Healthcare, Syracuse VA Medical Center (116C), 800 Irving Ave, Syracuse, NY 13210, USA. paigec.ouimette@med.va.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1415 EP - 1423 VL - 31 IS - 8 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Humans KW - Health Surveys KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Comorbidity KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Health Status KW - Quality of Life KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68689537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Health+and+well+being+of+substance+use+disorder+patients+with+and+without+posttraumatic+stress+disorder.&rft.au=Ouimette%2C+Paige%3BGoodwin%2C+Elizabeth%3BBrown%2C+Pamela+J&rft.aulast=Ouimette&rft.aufirst=Paige&rft.date=2006-08-01&rft.volume=31&rft.issue=8&rft.spage=1415&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-29 N1 - Date created - 2006-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relapse to opioid use after treatment of chronic hepatitis C with pegylated interferon and ribavirin. AN - 68687880; 16877644 JF - The American journal of psychiatry AU - Matthews, Annette M AU - Fireman, Marian AU - Zucker, Betsy AU - Sobel, Michelle AU - Hauser, Peter AD - Portland VA Medical Center, 3710 S.W. U.S. Veteran Hospital Rd., P.O. Box 1035 (V3MHC), Portland, OR 97202, USA. annette.matthews@med.va.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1342 EP - 7; quiz 1479 VL - 163 IS - 8 SN - 0002-953X, 0002-953X KW - Antiviral Agents KW - 0 KW - Ribavirin KW - 49717AWG6K KW - Interferons KW - 9008-11-1 KW - Methadone KW - UC6VBE7V1Z KW - Abridged Index Medicus KW - Index Medicus KW - Drug Administration Schedule KW - Methadone -- therapeutic use KW - Behavior, Addictive -- epidemiology KW - Humans KW - Cocaine-Related Disorders -- psychology KW - Behavior, Addictive -- psychology KW - Patient Care Planning KW - Cocaine-Related Disorders -- epidemiology KW - Cocaine-Related Disorders -- rehabilitation KW - Recurrence KW - Behavior, Addictive -- diagnosis KW - Comorbidity KW - Risk Assessment KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Antiviral Agents -- therapeutic use KW - Antiviral Agents -- administration & dosage KW - Ribavirin -- therapeutic use KW - Opioid-Related Disorders -- psychology KW - Substance Abuse, Intravenous -- rehabilitation KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- epidemiology KW - Opioid-Related Disorders -- rehabilitation KW - Substance Abuse, Intravenous -- epidemiology KW - Interferons -- administration & dosage KW - Interferons -- therapeutic use KW - Opioid-Related Disorders -- epidemiology KW - Ribavirin -- administration & dosage KW - Substance Abuse, Intravenous -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68687880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Relapse+to+opioid+use+after+treatment+of+chronic+hepatitis+C+with+pegylated+interferon+and+ribavirin.&rft.au=Matthews%2C+Annette+M%3BFireman%2C+Marian%3BZucker%2C+Betsy%3BSobel%2C+Michelle%3BHauser%2C+Peter&rft.aulast=Matthews&rft.aufirst=Annette&rft.date=2006-08-01&rft.volume=163&rft.issue=8&rft.spage=1342&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-07 N1 - Date created - 2006-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurocognitive function in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorder. AN - 68676114; 16866589 AB - Neuropsychological deficits have been reported among trauma survivors with posttraumatic stress disorder (PTSD). It is often assumed that these cognitive difficulties are toxic consequences of trauma exposure. Alternatively, they may reflect preexisting characteristics that contribute to the likelihood of developing PTSD. To address this possibility, the authors evaluated cognitive performance in monozygotic twin pairs who were discordant for combat exposure. Pairs were grouped according to whether the combat-exposed brother developed PTSD. The combat-unexposed cotwins of combat veterans with PTSD largely displayed the same performance as their brothers, which was significantly lower than that of non-PTSD combat veterans and their brothers. The results support the notion that specific domains of cognitive function may serve as premorbid risk or protective factors in PTSD. Copyright 2006 APA, all rights reserved. JF - Journal of abnormal psychology AU - Gilbertson, Mark W AU - Paulus, Lynn A AU - Williston, Stephanie K AU - Gurvits, Tamara V AU - Lasko, Natasha B AU - Pitman, Roger K AU - Orr, Scott P AD - Research Service, Manchester VA Medical Center, NH 03104, USA. mark.gilbertson@med.va.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 484 EP - 495 VL - 115 IS - 3 SN - 0021-843X, 0021-843X KW - Index Medicus KW - Severity of Illness Index KW - Humans KW - Adult KW - Neuropsychological Tests KW - Male KW - Warfare KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Brain -- physiopathology KW - Cognition Disorders -- diagnosis KW - Stress Disorders, Post-Traumatic -- psychology KW - Cognition Disorders -- epidemiology KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Cognition Disorders -- physiopathology KW - Twins, Monozygotic -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68676114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+abnormal+psychology&rft.atitle=Neurocognitive+function+in+monozygotic+twins+discordant+for+combat+exposure%3A+relationship+to+posttraumatic+stress+disorder.&rft.au=Gilbertson%2C+Mark+W%3BPaulus%2C+Lynn+A%3BWilliston%2C+Stephanie+K%3BGurvits%2C+Tamara+V%3BLasko%2C+Natasha+B%3BPitman%2C+Roger+K%3BOrr%2C+Scott+P&rft.aulast=Gilbertson&rft.aufirst=Mark&rft.date=2006-08-01&rft.volume=115&rft.issue=3&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Journal+of+abnormal+psychology&rft.issn=0021843X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-21 N1 - Date created - 2006-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development and verification of a "virtual" cohort using the National VA Health Information System. AN - 68656304; 16849965 AB - The VA's integrated electronic medical record makes it possible to create a "virtual" cohort of veterans with and without HIV infection to monitor trends in utilization, toxicity, and outcomes. We sought to develop a virtual cohort of HIV-infected veterans by adapting an existing algorithm, verifying this algorithm against independent clinical data, and finally identifying demographically-similar HIV-uninfected comparators. Subjects were identified from VA administrative data in fiscal years 1998-2003 using a modified existing algorithm, then linked with Immunology Case Registry (ICR, the VA's HIV registry) and Pharmacy Benefits Management (centralized database of outpatient prescriptions) to verify accuracy of identification. The algorithm was modified to maximize positive predictive value (PPV) against ICR. Finally, 2 HIV-uninfected comparators were matched to each HIV-infected subject. Using a single HIV code, 30,564 subjects were identified (positive predictive value 69%). Modification to require >1 outpatient or 1 inpatient code improved the positive predictive value to 88%. The lack of confirmatory laboratory and pharmacy data for the majority of subjects with a single outpatient code also supported this change. Of subjects identified with the modified algorithm, 89% had confirmatory evidence. When the modified algorithm was applied to fiscal years 1997-2004, 33,420 HIV-infected subjects were identified. Two HIV-uninfected comparators were matched to each subject for an overall cohort sample of 100,260. In the HAART era, HIV-related codes are sufficient for identifying HIV-infected subjects from administrative data when patients with a single outpatient code are excluded. A large cohort of HIV-infected subjects and matched comparators can be identified from existing VA administrative datasets. JF - Medical care AU - Fultz, Shawn L AU - Skanderson, Melissa AU - Mole, Larry A AU - Gandhi, Neel AU - Bryant, Kendall AU - Crystal, Stephen AU - Justice, Amy C AD - VA Connecticut Health Care System, West Haven, CT 06516, USA. amy.justice2@va.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - S25 EP - S30 VL - 44 IS - 8 Suppl 2 SN - 0025-7079, 0025-7079 KW - Index Medicus KW - United States KW - Medical Records Systems, Computerized KW - United States Department of Veterans Affairs KW - Humans KW - Adult KW - Algorithms KW - Aged KW - Middle Aged KW - Male KW - Female KW - Information Systems KW - Cohort Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68656304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Development+and+verification+of+a+%22virtual%22+cohort+using+the+National+VA+Health+Information+System.&rft.au=Fultz%2C+Shawn+L%3BSkanderson%2C+Melissa%3BMole%2C+Larry+A%3BGandhi%2C+Neel%3BBryant%2C+Kendall%3BCrystal%2C+Stephen%3BJustice%2C+Amy+C&rft.aulast=Fultz&rft.aufirst=Shawn&rft.date=2006-08-01&rft.volume=44&rft.issue=8+Suppl+2&rft.spage=S25&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-29 N1 - Date created - 2006-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Social Work in the Department of Veterans Affairs: Lessons Learned AN - 61300586; 200605086 AB - Following a brief historical overview of the psychosocial services provided through the US Dept of Veterans Affairs (VA) since 1926, challenges faced by social workers in this organization are explored. It is demonstrated how periods of massive expansion of the number of & roles for social workers (post-WWII & the 1960s) were followed by declines that accompanied the VA's reorganization & decentralization in the 1990s. New efforts to revitalize VA social work at the close of the 20th century are described, along with new challenges presented by the veterans of recent wars in Afghanistan & Iraq. References. K. Hyatt Stewart JF - Health & Social Work AU - Manske, Jill E AD - Social Work Service, VA Central Office, Washington, DC jill.manske@va.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 233 EP - 238 PB - National Association of Social Workers, Washington DC VL - 31 IS - 3 SN - 0360-7283, 0360-7283 KW - Veterans KW - Client Relations KW - War KW - Clinical Social Work KW - Government Agencies KW - Social Workers KW - Delivery Systems KW - Hospitals KW - article KW - 6120: social work practice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61300586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+%26+Social+Work&rft.atitle=Social+Work+in+the+Department+of+Veterans+Affairs%3A+Lessons+Learned&rft.au=Manske%2C+Jill+E&rft.aulast=Manske&rft.aufirst=Jill&rft.date=2006-08-01&rft.volume=31&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Health+%26+Social+Work&rft.issn=03607283&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-10-30 N1 - Last updated - 2016-09-28 N1 - CODEN - HSWOEL N1 - SubjectsTermNotLitGenreText - Social Workers; Clinical Social Work; Veterans; Client Relations; Government Agencies; Hospitals; War; Delivery Systems ER - TY - JOUR T1 - Development and Evaluation of a Multifaceted Ergonomics Program to Prevent Injuries Associated with Patient Handling Tasks AN - 57056385; 200615178 AB - Problem statement: Nurses have one of the highest rates of work-related musculoskeletal injury of any profession. Over the past 30 years, efforts to reduce work-related musculoskeletal disorders in nurses have been largely unsuccessful. Specific aims: The primary goal of this program was to create safer working environments for nursing staff who provide direct patient care. Our first objective was to design & implement a multifaceted program that successfully integrated evidence-based practice, technology, & safety improvement. The second objective was to evaluate the impact of the program on injury rate, lost & modified work days, job satisfaction, self-reported unsafe patient handling acts, level of support for program, staff & patient acceptance, program effectiveness, costs, & return on investment. Intervention: The intervention included six program elements: (1) Ergonomic Assessment Protocol, (2) Patient Handling Assessment Criteria & Decision Algorithms, (3) Peer Leader role, "Back Injury Resource Nurses," (4) State-of-the-art Equipment, (5) After Action Reviews, & (6) No Lift Policy. Methods: A pre-/post design without a control group was used to evaluate the effectiveness of a patient care ergonomics program on 23 high risk units (19 nursing home care units & 4 spinal cord injury units) in 7 facilities. Injury rates, lost work days, modified work days, job satisfaction, staff , & patient acceptance, program effectiveness, & program costs/savings were compared over two nine month periods: pre-intervention (May 2001-January 2002) & post-intervention (March 2002-November 2002). Data were collected prospectively through surveys, weekly process logs, injury logs, & cost logs. Results: The program elements resulted in a statistically significant decrease in the rate of musculoskeletal injuries as well as the number of modified duty days taken per injury. While the total number of lost workdays decreased by 18% post-intervention, this difference was not statistically significant. There were statistically significant increases in two subscales of job satisfaction: professional status & tasks requirements. Self-reports by nursing staff revealed a statistically significant decrease in the number of 'unsafe' patient handling practices performed daily. Nurses ranked program elements they deemed to be "extremely effective": equipment was rated as most effective (96%), followed by No Lift Policy (68%), peer leader education program (66%), ergonomic assessment protocol (59%), patient handling assessment criteria & decision algorithms (55%), & lastly after action reviews (41%). Perceived support & interest for the program started at a high level for managers & nursing staff & remained very high throughout the program implementation. Patient acceptance was moderate when the program started but increased to very high by the end of the program. Although the ease & success of program implementation initially varied between & within the facilities, after six months there was strong evidence of support at all levels. The initial capital investment for patient handling equipment was recovered in approximately 3.75 years based on annual post-intervention savings of over $200,000/year in workers' compensation expenses & cost savings associated with reduced lost & modified work days & worker compensation. Conclusions: This multi-faceted program resulted in an overall lower injury rate, fewer modified duty days taken per injury, & significant cost savings. The program was well accepted by patients, nursing staff, & administrators. Given the significant increases in two job satisfaction subscales (professional status & task requirements), it is possible that nurse recruitment & retention could be positively impacted. 8 Tables, 3 Figures, 46 References. [Copyright 2005 Elsevier Ltd.] JF - International Journal of Nursing Studies AU - Nelson, Audrey AU - Matz, Mary AU - Chen, Fangfei AU - Siddharthan, Kris AU - Lloyd, John AU - Fragala, Guy AD - Patient Safety Center Inquiry, James A. Haley Veterans Hospital, Tampa, FL audrey.nelson@med.va.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 717 EP - 733 PB - Elsevier Ltd, UK VL - 43 IS - 6 SN - 0020-7489, 0020-7489 KW - Safe patient handling and movement KW - Patient safety KW - Ergonomics KW - Nursing KW - Nursing injuries KW - Injuries KW - Safety measures KW - Workplaces KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57056385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Nursing+Studies&rft.atitle=Development+and+Evaluation+of+a+Multifaceted+Ergonomics+Program+to+Prevent+Injuries+Associated+with+Patient+Handling+Tasks&rft.au=Nelson%2C+Audrey%3BMatz%2C+Mary%3BChen%2C+Fangfei%3BSiddharthan%2C+Kris%3BLloyd%2C+John%3BFragala%2C+Guy&rft.aulast=Nelson&rft.aufirst=Audrey&rft.date=2006-08-01&rft.volume=43&rft.issue=6&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Nursing+Studies&rft.issn=00207489&rft_id=info:doi/10.1016%2Fj.ijnurstu.2005.09.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-10-02 N1 - Last updated - 2016-09-27 N1 - CODEN - IJNUA6 N1 - SubjectsTermNotLitGenreText - Nursing; Injuries; Workplaces; Safety measures; Ergonomics DO - http://dx.doi.org/10.1016/j.ijnurstu.2005.09.004 ER - TY - JOUR T1 - Correlates of Depressive Symptoms Among Women Seeking Cancer Genetic Counseling and Risk Assessment at a High-Risk Cancer Clinic AN - 20829430; 7137927 AB - The aims of this study were to (1) assess the level of depression among women seeking cancer genetic counseling and risk assessment and to (2) identify and describe the demographic, health history, and health behavior correlates of clinically significant depression. Participants were 280 women presenting for an intake appointment at a university cancer risk clinic. During intake, participants completed questionnaires assessing demographics, health history, health practices, and depression. Twenty-eight percent of the sample met criteria for at least mild depression. Descriptive statistics indicated that depressed women were more likely to be African American, to have more children, less likely to receive a mammogram, and consumed fewer alcoholic drinks per week than nondepressed women. Given the known associations between depression, health behaviors such as cancer screening, and potential responses to the genetic testing process, assessment of mood disturbance remains an important consideration for genetic counselors. JF - Journal of Genetic Counseling AU - Kodl, Molly Middlecamp AU - Lee, Judith W AU - Matthews, Alicia K AU - Cummings, Shelly A AU - Olopade, Olufunmilayo I AD - Center for Chronic Disease Outcomes Research, VA Medical Center 152/3E, One Veteran's Drive, Minneapolis, Minnesota, 55417, USA, Molly.Kodl@va.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 267 EP - 276 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 15 IS - 4 SN - 1059-7700, 1059-7700 KW - Genetics Abstracts; Risk Abstracts KW - Risk assessment KW - Historical account KW - Inventories KW - Depression KW - Statistics KW - Beverages KW - Children KW - depression KW - Cancer KW - Alcoholics KW - Demography KW - Mood KW - Risk factors KW - Genetic screening KW - Risk groups KW - Females KW - Substance abuse KW - Ethnic groups KW - G 07880:Human Genetics KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20829430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Genetic+Counseling&rft.atitle=Correlates+of+Depressive+Symptoms+Among+Women+Seeking+Cancer+Genetic+Counseling+and+Risk+Assessment+at+a+High-Risk+Cancer+Clinic&rft.au=Kodl%2C+Molly+Middlecamp%3BLee%2C+Judith+W%3BMatthews%2C+Alicia+K%3BCummings%2C+Shelly+A%3BOlopade%2C+Olufunmilayo+I&rft.aulast=Kodl&rft.aufirst=Molly&rft.date=2006-08-01&rft.volume=15&rft.issue=4&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Journal+of+Genetic+Counseling&rft.issn=10597700&rft_id=info:doi/10.1007%2Fs10897-006-9025-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mood; Demography; Risk assessment; Inventories; Beverages; Statistics; Depression; Risk factors; Risk groups; Children; Alcoholics; Cancer; Historical account; Genetic screening; Females; depression; Ethnic groups; Substance abuse DO - http://dx.doi.org/10.1007/s10897-006-9025-8 ER - TY - JOUR T1 - CASE REPORTS: Robotic Implantation of a Multichamber Cardiac Resynchronization Therapy Defibrillator AN - 19967417; 7007825 AB - Transvenous implantation of a cardiac resynchronization therapy defibrillator (CRT-D) may not be feasible due to anatomic constraints. One of the most notable advances in minimal-access heart surgery has been the introduction of robotic telemanipulation systems. We present a challenging case in which a CRT-D system was implanted using a robotic approach. Feasibility of such an approach expands the horizons for delivery of CRT-D therapy. JF - Pacing and Clinical Electrophysiology AU - Shalaby, Alaa AU - Sharma, Mahesh S AU - Zenati, Marco A AD - Address for reprints: Alaa Shalaby, M.D., Director of Cardiac Electrophysiology, Pittsburgh VA Healthcare System, Assistant Professor of Medicine, University of Pittsburgh, Division of Cardiology, 111 C University Drive, Pittsburgh, PA 15240, alaa.shalaby@med.va.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 906 EP - 909 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 29 IS - 8 SN - 0147-8389, 0147-8389 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Case reports KW - Defibrillators KW - Surgery KW - robotics KW - Electrophysiology KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19967417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pacing+and+Clinical+Electrophysiology&rft.atitle=CASE+REPORTS%3A+Robotic+Implantation+of+a+Multichamber+Cardiac+Resynchronization+Therapy+Defibrillator&rft.au=Shalaby%2C+Alaa%3BSharma%2C+Mahesh+S%3BZenati%2C+Marco+A&rft.aulast=Shalaby&rft.aufirst=Alaa&rft.date=2006-08-01&rft.volume=29&rft.issue=8&rft.spage=906&rft.isbn=&rft.btitle=&rft.title=Pacing+and+Clinical+Electrophysiology&rft.issn=01478389&rft_id=info:doi/10.1111%2Fj.1540-8159.2006.00418.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - SuppNotes - Figures, 2; tables, 1; references, 7. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Case reports; Surgery; Defibrillators; robotics; Electrophysiology DO - http://dx.doi.org/10.1111/j.1540-8159.2006.00418.x ER - TY - JOUR T1 - The heat sensitivity of cytokine-inducing effect of lipopolysaccharide AN - 19771634; 7051642 AB - Heat inactivation by boiling has been widely used as a criterion to determine whether the observed effects of a protein preparation are a result of lipopolysaccharide (LPS) contamination. However, the heat sensitivity of LPS cytokine-inducing activity has not been characterized. In the current study, we demonstrated that the endotoxin activity, i.e., Limulus amebocyte lysate-gelating activity, and the tumor necrosis factor alpha (TNF- alpha )-inducing activity of LPS (Escherichia coli K-12 JM83, K-12 LCD25, and F583) were sensitive to boiling. Heat treatment by boiling for 15 min was sufficient to inactivate similar to 90% of the LPS TNF- alpha -inducing activity. The heat-induced inactivation of LPS activities was not a result of adherence of boiled LPS to the wall of the container, i.e., polypropylene tubes, or aggregation of boiled LPS. In addition, boiled LPS retained its ability to bind polymyxin B. The presence of protein (ovalbumin) in LPS did not affect the heat sensitivity of LPS. Conversely, boiling reduced the size of LPS aggregates as determined by electrophoresis using native polyacrylamide gel. Likewise, the TNF- alpha -inducing activity of diphosphoryl lipid A (DPLA) was also sensitive to boiling. Thin-layer chromatographic analysis of boiled DPLA revealed that the heat-induced inactivation of DPLA TNF- alpha -inducing activity was not a result of its conversion to monophosphoryl lipid A. We conclude that the TNF- alpha -inducing activity of LPS and DPLA is sensitive to boiling and suggest that heat sensitivity as an indicator of whether the observed effects of a protein preparation are a result of LPS contamination should be used with caution. JF - Journal of Leukocyte Biology AU - Gao, B AU - Wang, Y AU - Tsan, M-F AD - VA Medical Center (10R), 50 Irving Street, N.W., Washington, DC 20422, USA, baochong.gao@med.va.gov Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 359 EP - 366 VL - 80 IS - 2 SN - 0741-5400, 0741-5400 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Endotoxins KW - Monophosphoryl lipid A KW - Amebocytes KW - Ovalbumin KW - Electrophoresis KW - Contamination KW - Leukocytes KW - polymyxin B KW - polypropylene KW - Limulus KW - Heat KW - Boiling KW - Escherichia coli KW - Lipopolysaccharides KW - Lipid A KW - Tumor necrosis factor- alpha KW - Heat treatments KW - Heat inactivation KW - F 06955:Immunomodulation & Immunopharmacology KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19771634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=The+heat+sensitivity+of+cytokine-inducing+effect+of+lipopolysaccharide&rft.au=Gao%2C+B%3BWang%2C+Y%3BTsan%2C+M-F&rft.aulast=Gao&rft.aufirst=B&rft.date=2006-08-01&rft.volume=80&rft.issue=2&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Journal+of+Leukocyte+Biology&rft.issn=07415400&rft_id=info:doi/10.1189%2Fjlb.1205738 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Amebocytes; Monophosphoryl lipid A; Endotoxins; Ovalbumin; Electrophoresis; Contamination; Leukocytes; polymyxin B; polypropylene; Boiling; Heat; Lipopolysaccharides; Lipid A; Tumor necrosis factor- alpha; Heat treatments; Heat inactivation; Limulus; Escherichia coli DO - http://dx.doi.org/10.1189/jlb.1205738 ER - TY - JOUR T1 - Quality of Life and Exercise Performance in Patients in Sinus Rhythm Versus Persistent Atrial Fibrillation A Veterans Affairs Cooperative Studies Program Substudy AN - 19457983; 7008406 AB - Patients with diabetes, in particular patients with type 2 diabetes, are at a 2- to 4-fold higher risk of cardiovascular mortality compared with their nondiabetic peers. Patients with diabetes are also more likely to have silent ischemia and less likely to survive a myocardial infarction than nondiabetic patients. Recent studies with electron beam computed tomography (EBCT) have shown that subclinical atherosclerosis is common in patients with diabetes, and studies with myocardial perfusion scintigraphy (with single-photon emission computed tomography) or stress echocardiography have demonstrated that between 25% and 50% of asymptomatic diabetic patients have ischemia during exercise or pharmacological stress and that a substantial proportion of these patients go on to develop major cardiovascular events within several years. Clearly, asymptomatic diabetic patients include a subset of individuals at high risk of cardiovascular disease who would benefit from improved risk stratification beyond that possible with risk factor scoring systems alone. Single-photon emission computed tomography, stress echocardiography, and possibly EBCT or multi-slice computed tomography, are emerging as valuable diagnostic tools for identifying asymptomatic diabetic patients who might require early and aggressive intervention to manage their cardiovascular risk. The Potential of Myocardial Perfusion Scintigraphy for Risk Stratification of Asymptomatic Patients With Type 2 Diabetes Jeroen J. Bax, Robert O. Bonow, Diethelm Tschoepe, Silvio E. Inzucchi, Eugene Barrett, on behalf of the Global Dialogue Group for the Evaluation of Cardiovascular Risk in Patients With Diabetes xxx JF - Journal of the American College of Cardiology AU - Singh, Steven N AU - Tang, XCharlene AU - Singh, Bramah N AU - Dorian, Paul AU - Reda, Domenic J AU - Harris, Crystal L AU - Fletcher, Ross D AU - Sharma, Satish C AU - Atwood, JEdwin AU - Jacobson, Alan K AU - Daniel, H AU - Lopez, Becky AU - Raisch, Dennis W AU - Ezekowitz, Michael D AD - Department of Veterans Affairs Medical Center, Washington, DC, steve.singh@med.va.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 721 EP - 730 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.com] VL - 48 IS - 4 SN - 0735-1097, 0735-1097 KW - Physical Education Index KW - Programs KW - Echocardiography KW - Stress KW - Patients KW - Exercise KW - Lifestyle KW - Diabetes KW - Evaluation KW - Peers KW - Blood flow KW - Risk factors KW - Higher education KW - Cardiorespiratory KW - Diseases KW - Performance KW - Rhythm KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19457983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Quality+of+Life+and+Exercise+Performance+in+Patients+in+Sinus+Rhythm+Versus+Persistent+Atrial+Fibrillation+A+Veterans+Affairs+Cooperative+Studies+Program+Substudy&rft.au=Singh%2C+Steven+N%3BTang%2C+XCharlene%3BSingh%2C+Bramah+N%3BDorian%2C+Paul%3BReda%2C+Domenic+J%3BHarris%2C+Crystal+L%3BFletcher%2C+Ross+D%3BSharma%2C+Satish+C%3BAtwood%2C+JEdwin%3BJacobson%2C+Alan+K%3BDaniel%2C+H%3BLopez%2C+Becky%3BRaisch%2C+Dennis+W%3BEzekowitz%2C+Michael+D&rft.aulast=Singh&rft.aufirst=Steven&rft.date=2006-08-01&rft.volume=48&rft.issue=4&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/10.1016%2Fj.jacc.2006.03.051 LA - English DB - Physical Education Index N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Programs; Echocardiography; Stress; Patients; Exercise; Diabetes; Lifestyle; Evaluation; Peers; Blood flow; Risk factors; Higher education; Cardiorespiratory; Performance; Diseases; Rhythm DO - http://dx.doi.org/10.1016/j.jacc.2006.03.051 ER - TY - JOUR T1 - Anti-CD25 Antibody Treatment of Mice Vaccinated and Challenged with Borrelia spp. Does Not Exacerbate Arthritis but Inhibits Borreliacidal Antibody Production AN - 19366095; 7131055 AB - CD4 super(+) CD25 super(+) T cells are a population of regulatory T cells responsible for the modulation of the immune response in several autoimmune and infectious disease models. We previously showed that adoptive transfer of enriched CD4 super(+) CD25 super(+) T cells also plays a major role in the prevention of arthritis in Borrelia-vaccinated (Borrelia burgdorferi isolate 297) and -challenged (B. bissettii) mice. Here, we present evidence that administration of anti-CD25 antibody at the time of challenge or at later intervals fails to enhance the development of severe destructive osteoarthropathy in Borrelia-vaccinated C57BL mice. However, Borrelia-vaccinated and -challenged mice receiving anti-CD25 antibody developed decreased borreliacidal antibody titers compared to vaccinated and challenged controls. These findings suggest that additional mechanisms besides CD4 super(+) CD25 super(+) T cells are involved in the regulation of the immune response to Borrelia infection following vaccination. JF - Clinical and Vaccine Immunology AU - Nardelli, Dean T AU - Warner, Thomas F AU - Callister, Steven M AU - Schell, Ronald F AD - Wisconsin State Laboratory of Hygiene and Departments of. Comparative Biomedical Sciences. Bacteriology. Medical Microbiology and Immunology, University of Wisconsin. Department of Pathology, Veterans Administration Hospital, Madison. Microbiology Research Laboratory and Section of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, Wisconsin Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 884 EP - 891 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 13 IS - 8 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Immunoregulation KW - Borrelia burgdorferi KW - Animal models KW - Infection KW - CD25 antigen KW - Vaccination KW - osteoarthropathy KW - CD4 antigen KW - Antibodies KW - Infectious diseases KW - Arthritis KW - Adoptive transfer KW - Lymphocytes T KW - Vaccines KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Anti-CD25+Antibody+Treatment+of+Mice+Vaccinated+and+Challenged+with+Borrelia+spp.+Does+Not+Exacerbate+Arthritis+but+Inhibits+Borreliacidal+Antibody+Production&rft.au=Nardelli%2C+Dean+T%3BWarner%2C+Thomas+F%3BCallister%2C+Steven+M%3BSchell%2C+Ronald+F&rft.aulast=Nardelli&rft.aufirst=Dean&rft.date=2006-08-01&rft.volume=13&rft.issue=8&rft.spage=884&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Immunoregulation; Animal models; CD25 antigen; Infection; Vaccination; Antibodies; CD4 antigen; osteoarthropathy; Infectious diseases; Arthritis; Lymphocytes T; Adoptive transfer; Vaccines; Borrelia burgdorferi ER - TY - JOUR T1 - Use of a modified informed consent process among vulnerable patients: A descriptive study AN - 1815699498; PQ0003594629 AB - BACKGROUND: Little is known about patient characteristics associated with comprehension of consent information, and whether modifications to the consent process can promote understanding. OBJECTIVE: To describe a modified research consent process, and determine whether literacy and demographic characteristics are associated with understanding consent information. DESIGN: Descriptive study of a modified consent process: consent form (written at a sixth-grade level) read to participants, combined with 7 comprehension questions and targeted education, repeated until comprehension achieved (teach-to-goal). PARTICIPANTS: Two hundred and four ethnically diverse subjects, aged greater than or equal to 50, consenting for a trial to improve the forms used for advance directives. MEASUREMENTS: Number of passes through the consent process required to achieve complete comprehension. Literacy assessed in English and Spanish with the Short Form Test of Functional Health Literacy in Adults (scores 0 to 36). RESULTS: Participants had a mean age of 61 years and 40% had limited literacy (s-TOHFLA.05). After the second pass, most subjects (80%) answered all questions correctly. With a teach-to-goal strategy, 98% of participants who engaged in the consent process achieved complete comprehension. CONCLUSIONS: Lower literacy and minority status are important determinants of understanding consent information. Using a modified consent process, little additional education was required to achieve complete comprehension, regardless of literacy or language barriers. JF - Journal of General Internal Medicine AU - Sudore, Rebecca L AU - Seth Landefeld, C AU - Williams, Brie A AU - Barnes, Deborah E AU - Lindquist, Karla AU - Schillinger, Dean AD - Division of Geriatrics, San Francisco Veterans Administration Medical Center, University of California, San Francisco, CA, USA, rsucsf@yahoo.com Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 867 EP - 873 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 21 IS - 8 SN - 0884-8734, 0884-8734 KW - Biotechnology and Bioengineering Abstracts KW - Demography KW - Age KW - Language KW - Clinical trials KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815699498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+General+Internal+Medicine&rft.atitle=Use+of+a+modified+informed+consent+process+among+vulnerable+patients%3A+A+descriptive+study&rft.au=Sudore%2C+Rebecca+L%3BSeth+Landefeld%2C+C%3BWilliams%2C+Brie+A%3BBarnes%2C+Deborah+E%3BLindquist%2C+Karla%3BSchillinger%2C+Dean&rft.aulast=Sudore&rft.aufirst=Rebecca&rft.date=2006-08-01&rft.volume=21&rft.issue=8&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=Journal+of+General+Internal+Medicine&rft.issn=08848734&rft_id=info:doi/10.1111%2Fj.1525-1497.2006.00535.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 51 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Demography; Age; Language; Clinical trials DO - http://dx.doi.org/10.1111/j.1525-1497.2006.00535.x ER - TY - JOUR T1 - Chronic ethanol consumption down-regulates CMP-NeuAc:GM sub(3) alpha 2,8-sialyltransferase (ST8Sia-1) gene in the rat brain AN - 17249779; 6967634 AB - Alcoholics have an increase in sialic acid-deficient glycoconjugates such as carbohydrate-deficient transferrin, sialic acid-deficient gangliosides and free sialic acids. The elevated presence of these asialoconjugates could be a consequence of alcohol-mediated impaired sialylation rate or due to increased desialylation rate. Chronic ethanol-induced brain abnormalities and behavioral changes could be mediated through these asialogangliosides. We have therefore determined the level of brain CMP-NeuAc:GM sub(3) alpha 2,8-sialyltransferase (ST8Sia- 1) and Gal- beta 1,3GalNAc alpha 2,3-sialyltransferase (ST3Gal-11) messenger RNA (mRNA) and correlated with the activity of these key enzymes in male Wistar rats as a function of increasing dietary concentration of ethanol after 8 weeks of feeding. The relative level of brain synaptosomal ST8Sia-1 and ST3Gal-11 mRNA were determined by real-time quantitative polymerase chain reaction (RT-PCR). We compared the observed ST8Sia-1 gene expression with its enzymatic activity in the synaptosomal membrane fraction isolated from the rat brain in the ethanol and pair-fed control groups. The results showed that the relative level of brain ST8Sia-1 mRNA expression was down-regulated by 13% (p - 0.05) in 10.6%, by 40% (p - 0.01) in 20.8% and by 57% (p - 0.01) in the 36% ethanol-calorie groups, compared to the control (0% ethanol-calorie) group. In addition, ethanol at 36% dietary calories caused a significant 61% (p - 0.01) decrease in the brain synaptosomal ST8Sia-1 activity compared to the control group. However, ethanol (10.6, 20.8 or 36% level) did not significantly affect the relative level of brain ST3Gal-11 mRNA as compared to the control (0% ethanol-calorie) group. Thus, our findings imply that chronic ethanol exposure preferentially down-regulates brain ST8Sia-1 mRNA accompanied by a concomitant decrease in its activity in a dose-dependent manner. Therefore, the selective loss of 2,8-sialic acid residues from gangliosides might contribute towards the appearance of asialogangliosides and related brain-abnormalities associated with ethanol abuse. JF - Neurochemistry International AU - Garige, Mamatha AU - Azuine, Magnus A AU - Lakshman, MRaj AD - The Lipid Research Laboratory (151-T), Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA, raj.lakshman@med.va.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 312 EP - 318 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 49 IS - 3 SN - 0197-0186, 0197-0186 KW - Genetics Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Transcription KW - Gene expression KW - Sialyltransferase KW - Alcoholism KW - Ethanol KW - Brain KW - Feeding KW - Calories KW - Enzymes KW - Gangliosides KW - Drug abuse KW - Neolactotetraosylceramide alpha -2,3-sialyltransferase KW - Alcoholics KW - Abuse KW - mRNA KW - glycoconjugates KW - Transferrin KW - Polymerase chain reaction KW - Enzymatic activity KW - Sialic acids KW - X 24380:Social Poisons & Drug Abuse KW - N3 11106:Neurobiology of drug abuse KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17249779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+International&rft.atitle=Chronic+ethanol+consumption+down-regulates+CMP-NeuAc%3AGM+sub%283%29+alpha+2%2C8-sialyltransferase+%28ST8Sia-1%29+gene+in+the+rat+brain&rft.au=Garige%2C+Mamatha%3BAzuine%2C+Magnus+A%3BLakshman%2C+MRaj&rft.aulast=Garige&rft.aufirst=Mamatha&rft.date=2006-08-01&rft.volume=49&rft.issue=3&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+International&rft.issn=01970186&rft_id=info:doi/10.1016%2Fj.neuint.2006.02.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Feeding; Calories; Brain; Enzymes; Gangliosides; Drug abuse; Abuse; Alcoholics; Neolactotetraosylceramide alpha -2,3-sialyltransferase; mRNA; Gene expression; Transferrin; glycoconjugates; Polymerase chain reaction; Enzymatic activity; Sialic acids; Ethanol DO - http://dx.doi.org/10.1016/j.neuint.2006.02.001 ER - TY - JOUR T1 - Predictors of retention in methadone programs: a signal detection analysis. AN - 68576743; 16384657 AB - Retention in Opioid Agonist Therapy (OAT) is associated with reductions in substance use, HIV risk behavior, and criminal activities in opioid dependent patients. To improve the effectiveness of treatment for opioid dependence, it is important to identify predisposing characteristics and provider-related variables that predict retention in OAT. Participants include 258 veterans enrolled in 8 outpatient methadone/l-alpha-acetylmethadol (LAAM) treatment programs. Signal detection analysis was utilized to identify variables predictive of 1-year retention and to identify the optimal cut-offs for significant predictors. Provider-related variables play a vital role in predicting retention in OAT programs, as higher methadone dose (> or =59 mg/day) and greater treatment satisfaction were among the strongest predictors of retention at 1-year follow-up. JF - Drug and alcohol dependence AU - Villafranca, Steven W AU - McKellar, John D AU - Trafton, Jodie A AU - Humphreys, Keith AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System & Stanford University School of Medicine, CA, USA. Steven.Villafranca@va.gov Y1 - 2006/07/27/ PY - 2006 DA - 2006 Jul 27 SP - 218 EP - 224 VL - 83 IS - 3 SN - 0376-8716, 0376-8716 KW - Narcotics KW - 0 KW - Street Drugs KW - Methadyl Acetate KW - L59OC40KWJ KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Health Services Research -- statistics & numerical data KW - Risk-Taking KW - Patient Satisfaction KW - Dose-Response Relationship, Drug KW - Humans KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Counseling KW - Comorbidity KW - Socioeconomic Factors KW - California KW - Combined Modality Therapy -- psychology KW - Adult KW - HIV Infections -- prevention & control KW - Middle Aged KW - Follow-Up Studies KW - Combined Modality Therapy -- statistics & numerical data KW - HIV Infections -- psychology KW - Male KW - Female KW - Substance-Related Disorders -- epidemiology KW - Methadone -- therapeutic use KW - Veterans -- statistics & numerical data KW - Heroin Dependence -- epidemiology KW - Veterans -- psychology KW - Patient Dropouts -- statistics & numerical data KW - Narcotics -- therapeutic use KW - Narcotics -- agonists KW - Heroin Dependence -- rehabilitation KW - Patient Dropouts -- psychology KW - Methadyl Acetate -- therapeutic use KW - Heroin Dependence -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68576743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Predictors+of+retention+in+methadone+programs%3A+a+signal+detection+analysis.&rft.au=Villafranca%2C+Steven+W%3BMcKellar%2C+John+D%3BTrafton%2C+Jodie+A%3BHumphreys%2C+Keith&rft.aulast=Villafranca&rft.aufirst=Steven&rft.date=2006-07-27&rft.volume=83&rft.issue=3&rft.spage=218&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-15 N1 - Date created - 2006-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The validity and reliability of a brief measure of cocaine craving. AN - 68576118; 16384655 AB - Although craving plays an important role in relapse, there are few brief, valid and reliable instruments to measure the desire to use cocaine in routine clinical practice. The 45-item Cocaine Craving Questionnaire-Now (CCQ-Now) is widely used in research, but its length makes its use in everyday clinical work relatively impractical. This study sought to determine the psychometric properties of the CCQ-Brief, a measure composed of 10 items from the CCQ-Now, in treatment-seeking cocaine abusers. Subjects with cocaine abuse or dependence (n=247) completed the CCQ-Brief, the CCQ-Now, the Voris Cocaine Craving Scale, the Beck Depression Inventory-II, the Beck Anxiety Inventory, and the Addiction Severity Index. The CCQ-Brief was significantly correlated with the CCQ-Now (r=.85, p<.01), the CCQ-Now with the items in common with the CCQ-Brief removed (r=.78, p<.01), all four subscales of the VCCS (craving intensity: r=.47, p<.01; mood: r=.27, p<.01; energy: r=.30, p<.01; sick feelings: r=.28, p<.01), the BDI-II (r=.39, p<.01), the BAI (r=.35, p<.01) and recent drug use (r=.26, p<.01). The internal consistency of the CCQ-Brief was strong (alpha=.90). The CCQ-Brief is a valid and reliable instrument that can be easily administered as a measure of current cocaine craving. JF - Drug and alcohol dependence AU - Sussner, Bradley D AU - Smelson, David A AU - Rodrigues, Stephanie AU - Kline, Anna AU - Losonczy, Miklos AU - Ziedonis, Douglas AD - Mental Health and Behavioral Sciences, Department of Veterans Affairs-New Jersey Health Care System, Lyons Campus Bldg. 143, 1521 Knollcroft Road, Lyons, NJ 07930-5000, USA. Bradley.Sussner@med.va.gov Y1 - 2006/07/27/ PY - 2006 DA - 2006 Jul 27 SP - 233 EP - 237 VL - 83 IS - 3 SN - 0376-8716, 0376-8716 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Reproducibility of Results KW - Personality Inventory -- statistics & numerical data KW - Humans KW - Adult KW - Psychometrics -- statistics & numerical data KW - Middle Aged KW - Affect KW - Statistics as Topic KW - Male KW - Female KW - Substance Withdrawal Syndrome -- diagnosis KW - Cocaine-Related Disorders -- psychology KW - Surveys and Questionnaires KW - Substance Withdrawal Syndrome -- psychology KW - Cocaine-Related Disorders -- rehabilitation KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68576118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=The+validity+and+reliability+of+a+brief+measure+of+cocaine+craving.&rft.au=Sussner%2C+Bradley+D%3BSmelson%2C+David+A%3BRodrigues%2C+Stephanie%3BKline%2C+Anna%3BLosonczy%2C+Miklos%3BZiedonis%2C+Douglas&rft.aulast=Sussner&rft.aufirst=Bradley&rft.date=2006-07-27&rft.volume=83&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-15 N1 - Date created - 2006-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transgenic mice that overexpress the anti-apoptotic Bcl-2 protein have improved histological outcome but unchanged behavioral outcome after traumatic brain injury AN - 19841572; 7042681 AB - Increasing evidence suggests that apoptosis is a contributing factor to neuronal cell death in traumatic brain injury (TBI). There is increased expression, cleavage and activation of caspases as well as other proteins known to regulate apoptosis in neurons after TBI. These proteins include the proto-oncogene Bcl-2 which belongs to a family of proteins with both pro- and anti-apoptotic properties. To investigate the role of apoptosis in TBI and the importance of Bcl-2 protein on the severity and outcome of injury, Bcl-2 overexpressing transgenic and wild-type control mice were subjected to the controlled cortical impact model of TBI. There was no significant difference in the cleavage of caspase-3 or caspase-9 detected by Western blotting of hippocampal samples from transgenic or wild-type mice after TBI. Bcl-2 transgenic mice had smaller contusion volumes and increased numbers of surviving neurons in CA2 but not other regions of hippocampus compared to wild-type controls. By contrast, there was no difference in motor function determined by the round beam balance and wire grip tests between transgenic and wild-type mice after TBI. Cognitive function assessed by the Morris water maze was also not different between groups. These results suggest that overexpression of Bcl-2 is only partially neuroprotective and other members of this protein family may prove to be more important in protecting neurons from cell death. JF - Brain Research AU - Tehranian, R AU - Rose, ME AU - Vagni, V AU - Griffith, R P AU - Wu, S AU - Maits, S AU - Zhang, X AU - Clark, RSB AU - Dixon, CE AU - Kochanek, P M AU - Bernard, O AU - Graham, SH AD - V.A. Pittsburgh Healthcare Center, PA 15206, USA, steven.graham@med.va.gov Y1 - 2006/07/26/ PY - 2006 DA - 2006 Jul 26 SP - 126 EP - 135 PB - Elsevier B.V. VL - 1101 IS - 1 SN - 0006-8993, 0006-8993 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Caspase-9 KW - Western blotting KW - Brain injury KW - Apoptosis KW - Hippocampus KW - protein families KW - Neuroprotection KW - Transgenic mice KW - Cortex KW - Cognitive ability KW - Neurons KW - Caspase-3 KW - Bcl-2 protein KW - Traumatic brain injury KW - Proto-oncogenes KW - W 30925:Genetic Engineering KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19841572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Transgenic+mice+that+overexpress+the+anti-apoptotic+Bcl-2+protein+have+improved+histological+outcome+but+unchanged+behavioral+outcome+after+traumatic+brain+injury&rft.au=Tehranian%2C+R%3BRose%2C+ME%3BVagni%2C+V%3BGriffith%2C+R+P%3BWu%2C+S%3BMaits%2C+S%3BZhang%2C+X%3BClark%2C+RSB%3BDixon%2C+CE%3BKochanek%2C+P+M%3BBernard%2C+O%3BGraham%2C+SH&rft.aulast=Tehranian&rft.aufirst=R&rft.date=2006-07-26&rft.volume=1101&rft.issue=1&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/10.1016%2Fj.brainres.2006.05.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Western blotting; Caspase-9; Apoptosis; Brain injury; Hippocampus; protein families; Neuroprotection; Transgenic mice; Cortex; Cognitive ability; Neurons; Caspase-3; Bcl-2 protein; Traumatic brain injury; Proto-oncogenes DO - http://dx.doi.org/10.1016/j.brainres.2006.05.049 ER - TY - JOUR T1 - Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): predictors for radiation pneumonitis and fibrosis. AN - 68573595; 16647222 AB - We aimed to report the final toxicity results on a radiation-dose escalation trial designed to test a hypothesis that very high doses of radiation could be safely administered to patients with non-small-cell lung cancer (NSCLC) by quantifying the dose-volume toxicity relationship of the lung. A total of 109 patients with unresectable or medically inoperable NSCLC were enrolled and treated with radiation-dose escalation (on the basis of predicted normal-lung toxicity) either alone or with neoadjuvant chemotherapy by use of 3D conformal techniques. Eighty-four patients (77%) received more than 69 Gy, the trial was stopped after the dose reached 103 Gy. Estimated median follow-up was 110 months. There were 17 (14.6%) Grade 2 to 3 pneumonitis and 15 (13.8%) Grade 2 to 3 fibrosis and no Grade 4 to 5 lung toxicity. Multivariate analyses showed them to be (1) not associated with the dose prescribed to the tumor, and (2) significantly (p<0.001) associated with lung-dosimetric parameters such as the mean lung dose (MLD), volume of lung that received at least 20 Gy (V20), and the normal-tissue complication probability (NTCP) of the lung. If cutoffs are 30% for V20, 20 Gy for MLD, and 10% for NTCP, these factors have positive predictive values of 50% to 71% and negative predictive value of 85% to 89%. With long-term follow-up for toxicity, we have demonstrated that much higher doses of radiation than are traditionally administered can be safely delivered to a majority of patients with NSCLC. Quantitative lung dose-volume toxicity-based dose escalation can form the basis for individualized high-dose radiation treatment to maximize the therapeutic ratio in these patients. JF - International journal of radiation oncology, biology, physics AU - Kong, Feng-Ming AU - Hayman, James A AU - Griffith, Kent A AU - Kalemkerian, Gregory P AU - Arenberg, Douglas AU - Lyons, Susan AU - Turrisi, Andrew AU - Lichter, Allen AU - Fraass, Benedick AU - Eisbruch, Avraham AU - Lawrence, Theodore S AU - Ten Haken, Randall K AD - Department of Radiation Oncology, University of Michigan, and Radiation Oncology, Veterans Administration Medical Center, Ann Arbor, MI 48109, USA. Fengkong@med.umich.edu Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 SP - 1075 EP - 1086 VL - 65 IS - 4 SN - 0360-3016, 0360-3016 KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Maximum Tolerated Dose KW - Dose-Response Relationship, Radiation KW - Male KW - Female KW - Chemotherapy, Adjuvant KW - Multivariate Analysis KW - Lung Neoplasms -- radiotherapy KW - Radiation Pneumonitis -- etiology KW - Radiation Pneumonitis -- pathology KW - Lung Neoplasms -- surgery KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Radiotherapy, Conformal -- adverse effects KW - Carcinoma, Non-Small-Cell Lung -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68573595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Final+toxicity+results+of+a+radiation-dose+escalation+study+in+patients+with+non-small-cell+lung+cancer+%28NSCLC%29%3A+predictors+for+radiation+pneumonitis+and+fibrosis.&rft.au=Kong%2C+Feng-Ming%3BHayman%2C+James+A%3BGriffith%2C+Kent+A%3BKalemkerian%2C+Gregory+P%3BArenberg%2C+Douglas%3BLyons%2C+Susan%3BTurrisi%2C+Andrew%3BLichter%2C+Allen%3BFraass%2C+Benedick%3BEisbruch%2C+Avraham%3BLawrence%2C+Theodore+S%3BTen+Haken%2C+Randall+K&rft.aulast=Kong&rft.aufirst=Feng-Ming&rft.date=2006-07-15&rft.volume=65&rft.issue=4&rft.spage=1075&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-07 N1 - Date created - 2006-06-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Nat Clin Pract Oncol. 2007 Feb;4(2):80-1 [17228308] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Evidence-Based Memory Preservation Diet@@uTM@ ©2005 to Reduce Risk and Slow Progression of Alzheimer's Disease (AD) T2 - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AN - 40192280; 4328763 JF - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AU - Lombardo, Nancy B. Emerson AU - Martin, Antonio AU - Volicer, Ladislav AU - Holmes, Michaelyn S AU - Zhang, Xui Wen Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Neurodegenerative diseases KW - Preservation KW - Alzheimer's disease KW - Memory UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40192280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.atitle=Evidence-Based+Memory+Preservation+Diet%40%40uTM%40+%26amp%3Bcopy%3B2005+to+Reduce+Risk+and+Slow+Progression+of+Alzheimer%27s+Disease+%28AD%29&rft.au=Lombardo%2C+Nancy+B.+Emerson%3BMartin%2C+Antonio%3BVolicer%2C+Ladislav%3BHolmes%2C+Michaelyn+S%3BZhang%2C+Xui+Wen&rft.aulast=Lombardo&rft.aufirst=Nancy+B.&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7B65136909%2 D91B3%2D4CC6%2DB889%2D7ACEB92BA9B6%7D&AKey=%7B50E1744A%2D0C52%2D45B2 %2DBF85%2D2A798BF24E02%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain Derived Neurotrophic Factor (BDNF) MRNA Expression is Reduced in Postmortem Hippocampal Dentate Gyrus in Alzheimers Disease and Dementia with Lewy Bodies T2 - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AN - 40189343; 4328331 JF - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AU - Raskind, Murray A AU - Leverenz, James B AU - Peskind, Elaine R AU - White, Sylvia S AU - Greenup, J Lynne AU - Szot, Patricia Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Brain-derived neurotrophic factor KW - Dementia disorders KW - Hippocampus KW - Alzheimer's disease KW - Gene expression KW - Dentate gyrus KW - Lewy bodies KW - Neurodegenerative diseases KW - Neurotrophic factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40189343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.atitle=Brain+Derived+Neurotrophic+Factor+%28BDNF%29+MRNA+Expression+is+Reduced+in+Postmortem+Hippocampal+Dentate+Gyrus+in+Alzheimers+Disease+and+Dementia+with+Lewy+Bodies&rft.au=Raskind%2C+Murray+A%3BLeverenz%2C+James+B%3BPeskind%2C+Elaine+R%3BWhite%2C+Sylvia+S%3BGreenup%2C+J+Lynne%3BSzot%2C+Patricia&rft.aulast=Raskind&rft.aufirst=Murray&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7B65136909%2 D91B3%2D4CC6%2DB889%2D7ACEB92BA9B6%7D&AKey=%7B50E1744A%2D0C52%2D45B2 %2DBF85%2D2A798BF24E02%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessing Capacity to Give Informed Consent in Outpatients with Mild-to-Moderate Alzheimer's Disease T2 - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AN - 40178584; 4329403 DE: JF - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AU - Dysken, Maurice AU - Love, Susan AU - Guarino, Peter Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40178584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.atitle=Assessing+Capacity+to+Give+Informed+Consent+in+Outpatients+with+Mild-to-Moderate+Alzheimer%27s+Disease&rft.au=Dysken%2C+Maurice%3BLove%2C+Susan%3BGuarino%2C+Peter&rft.aulast=Dysken&rft.aufirst=Maurice&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7B65136909%2 D91B3%2D4CC6%2DB889%2D7ACEB92BA9B6%7D&AKey=%7B50E1744A%2D0C52%2D45B2 %2DBF85%2D2A798BF24E02%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Clinical validity of the SWAL-QOL and SWAL-CARE outcome tools with respect to bolus flow measures. AN - 85397423; pmid-16715210 AB - The aim of this study was to quantify the association between a dysphagia-specific quality of life (SWAL-QOL) and quality of care (SWAL-CARE) questionnaire and four measures of bolus flow. Three hundred eighty-six people with oropharyngeal dysphagia completed a videofluoroscopic examination of their swallowing structure and physiology. They also completed the SWAL-QOL and SWAL-CARE surveys. Measures of bolus flow patterns for each swallow were analyzed from videofluoroscopic recordings and correlated with the SWAL-QOL and SWAL-CARE scale scores. The SWAL-QOL and SWAL-CARE scales were modestly related to the four measures of the bolus flow. The SWAL-QOL and SWAL-CARE were most related to measures of oral transit duration and total swallow duration. The SWAL-QOL and SWAL-CARE scales were least related to pharyngeal transit duration. Results were stronger for semisolid trials than for liquid trials. Results were generally weak for the Penetration Aspiration Scale. For all of the significant relationships, the greater the bolus flow severity, the worse the quality of life. The observed modest correlations suggest that patient-centered quality-of-life measures and clinician-driven bolus flow measures provide distinct yet complementary information about oropharyngeal dysphagia. Both sets of measures should be used in dysphagia effectiveness and outcomes research. JF - Dysphagia AU - McHorney, Colleen A AU - Martin-Harris, Bonnie AU - Robbins, JoAnne AU - Rosenbek, John AD - Roudebush Veterans Administration Medical Center, Indiana University School of Medicine, Indianapolis, IN, USA. colleen_mchorney@merck.com Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 141 EP - 148 VL - 21 IS - 3 SN - 0179-051X, 0179-051X KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - *Deglutition Disorders: physiopathology KW - *Deglutition Disorders: psychology KW - Female KW - Fluoroscopy KW - Humans KW - Male KW - Middle Aged KW - Outcome Assessment (Health Care) KW - Patient Satisfaction KW - *Psychometrics: methods KW - *Quality of Health Care: standards KW - *Quality of Life KW - Questionnaires KW - Regression Analysis KW - Videotape Recording UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85397423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dysphagia&rft.atitle=Clinical+validity+of+the+SWAL-QOL+and+SWAL-CARE+outcome+tools+with+respect+to+bolus+flow+measures.&rft.au=McHorney%2C+Colleen+A%3BMartin-Harris%2C+Bonnie%3BRobbins%2C+JoAnne%3BRosenbek%2C+John&rft.aulast=McHorney&rft.aufirst=Colleen&rft.date=2006-07-01&rft.volume=21&rft.issue=3&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Dysphagia&rft.issn=0179051X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Erratum In: Dysphagia. 2008 Dec;23(4):461 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Sequencing versus nonsequencing working memory in understanding of rapid speech by older listeners. AN - 85395060; pmid-16927515 AB - The goal of this study was to identify specific neurocognitive deficits that are associated with older listeners' difficulty understanding rapid speech. Older listeners performed speech recognition tests comprised of time-compressed sentences with and without context, and on a neurocognitive battery aimed specifically at testing working memory, processing speed, and attention. A principle component analysis identified three main cognitive components as follows: a sequencing working memory (WM-S) component, a nonsequencing working memory (WM-NS) component, and a processing speed (PS) component. Each of the cognitive component scores was divided into high, mid, and low categories. Sentence performance of the cognitive subgroups was compared within each component. The results showed that, with hearing loss and age accounted for, the cognitive score groups differed similarly on the sentence condition scores also at 50 and 60% time compression, particularly on the subgroups of the WM-S component. The results suggest that deficits in a separate working memory function identified as sequencing were associated with differences in ability to understand time-compressed speech in this study. JF - Journal of the American Academy of Audiology AU - Vaughan, Nancy AU - Storzbach, Daniel AU - Furukawa, Izumi AD - National Center for Rehabilitative Auditory Research, Portland Veterans Affairs Medical Center, Portland, OR 97239, USA. nancy.vaughan@med.va.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 506 EP - 518 VL - 17 IS - 7 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Age Factors KW - Aged KW - *Aging: physiology KW - Attention KW - Audiometry, Pure-Tone KW - Audiometry, Speech KW - *Auditory Perceptual Disorders: etiology KW - Auditory Perceptual Disorders: physiopathology KW - *Cognition: physiology KW - Female KW - *Hearing Loss: physiopathology KW - Humans KW - Male KW - *Memory: physiology KW - Middle Aged KW - Neuropsychological Tests KW - *Speech Perception: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Sequencing+versus+nonsequencing+working+memory+in+understanding+of+rapid+speech+by+older+listeners.&rft.au=Vaughan%2C+Nancy%3BStorzbach%2C+Daniel%3BFurukawa%2C+Izumi&rft.aulast=Vaughan&rft.aufirst=Nancy&rft.date=2006-07-01&rft.volume=17&rft.issue=7&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Identification and treatment of alcohol use disorders in the perioperative period. AN - 68847005; 16961052 AB - Patients with alcohol use disorders who undergo surgery face added risks and longer recovery time. Identification of such patients may reduce these risks, allow physicians to increase awareness of surgical requirements, and minimize postoperative complications. This article defines the alcohol problems encountered, describes preoperative screening tests and treatments, and discusses postoperative assessment and management of complications such as alcohol withdrawal syndrome. JF - Postgraduate medicine AU - Gordon, Adam J AU - Olstein, Josh AU - Conigliaro, Joseph AD - University of Pittsburgh School of Medicine, Center for Health Equity Research and Promotion, Pennsylvania 15240, USA. adam.gordon@med.va.gov PY - 2006 SP - 46 EP - 55 VL - 119 IS - 2 SN - 0032-5481, 0032-5481 KW - Index Medicus KW - Postoperative Complications KW - Humans KW - Substance Withdrawal Syndrome -- therapy KW - Perioperative Care KW - Alcoholism -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68847005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+medicine&rft.atitle=Identification+and+treatment+of+alcohol+use+disorders+in+the+perioperative+period.&rft.au=Gordon%2C+Adam+J%3BOlstein%2C+Josh%3BConigliaro%2C+Joseph&rft.aulast=Gordon&rft.aufirst=Adam&rft.date=2006-07-01&rft.volume=119&rft.issue=2&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Postgraduate+medicine&rft.issn=00325481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-22 N1 - Date created - 2006-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Substance use disorder comorbidity in major depressive disorder: a confirmatory analysis of the STAR*D cohort. AN - 68677724; 16867922 AB - The demographics and clinical features were compared between those with (29.4%) and without concurrent substance use disorder (SUD) in 2541 outpatients with major depression (MDD) enrolled in the Sequenced Treatment Alternatives to Relieve Depression study. Compared to those without SUD, MDD patients with concurrent SUD were more likely to be younger, male, divorced or never married, and at greater current suicide risk, and have an earlier age of onset of depression, greater depressive symptomatology, more previous suicide attempts, more frequent concurrent anxiety disorders, and greater functional impairment (p = 0.048 to <0.0001). They were also less likely to be Hispanic and endorse general medical comorbidities (p = 0.006 and 0.002, respectively). JF - The American journal on addictions AU - Davis, Lori L AU - Frazier, Elizabeth AU - Husain, Mustafa M AU - Warden, Diane AU - Trivedi, Madhukar AU - Fava, Maurizio AU - Cassano, Paolo AU - McGrath, Patrick J AU - Balasubramani, G K AU - Wisniewski, Stephen R AU - Rush, A John AD - VA Medical Center, Tuscaloosa, AL 35404, USA. lori.davis@med.va.gov PY - 2006 SP - 278 EP - 285 VL - 15 IS - 4 SN - 1055-0496, 1055-0496 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Cyclohexanols KW - Bupropion KW - 01ZG3TPX31 KW - Citalopram KW - 0DHU5B8D6V KW - Venlafaxine Hydrochloride KW - 7D7RX5A8MO KW - Sertraline KW - QUC7NX6WMB KW - Index Medicus KW - Bupropion -- therapeutic use KW - Antidepressive Agents, Second-Generation -- therapeutic use KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Aged KW - Suicide -- psychology KW - Comorbidity KW - Adult KW - Anxiety Disorders -- epidemiology KW - Adolescent KW - Retreatment KW - Male KW - Anxiety Disorders -- psychology KW - Combined Modality Therapy KW - Anxiety Disorders -- diagnosis KW - Anxiety Disorders -- rehabilitation KW - Personality Inventory KW - Citalopram -- therapeutic use KW - Factor Analysis, Statistical KW - Sertraline -- therapeutic use KW - Cognitive Therapy KW - Risk Factors KW - Cohort Studies KW - Cyclohexanols -- therapeutic use KW - Female KW - Suicide -- prevention & control KW - Substance-Related Disorders -- diagnosis KW - Depressive Disorder, Major -- diagnosis KW - Depressive Disorder, Major -- psychology KW - Depressive Disorder, Major -- epidemiology KW - Depressive Disorder, Major -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68677724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Substance+use+disorder+comorbidity+in+major+depressive+disorder%3A+a+confirmatory+analysis+of+the+STAR*D+cohort.&rft.au=Davis%2C+Lori+L%3BFrazier%2C+Elizabeth%3BHusain%2C+Mustafa+M%3BWarden%2C+Diane%3BTrivedi%2C+Madhukar%3BFava%2C+Maurizio%3BCassano%2C+Paolo%3BMcGrath%2C+Patrick+J%3BBalasubramani%2C+G+K%3BWisniewski%2C+Stephen+R%3BRush%2C+A+John&rft.aulast=Davis&rft.aufirst=Lori&rft.date=2006-07-01&rft.volume=15&rft.issue=4&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2006-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vitro and in vivo evaluation of 111In-labeled E. coli heat-stable enterotoxin analogs for specific targeting of human breast cancers. AN - 68624431; 16724166 AB - Research into the interaction between the E. coli heat-stable enterotoxin (STh) and the guanylin receptor guanylate cyclase C (GC-C) has generated >100 synthetic analogs of the peptide, several of which have been investigated as imaging or therapeutic agents for colorectal cancers. The evidence presented here suggests that in addition to STh binding to GC-C expressing cell lines derived from human colon, STh also specifically binds to an as yet unidentified receptor expressed in high densities on the surface of cell lines derived from human breast cancers. In vitro whole-cell crosslinking studies using 125I-labeled F19-STh(1-19) demonstrate that the putative STh binding protein migrates as an approximately 120-125 kDa species by SDS-PAGE, significantly smaller than the glycosylated GC-C molecule found in the T84 human colon cancer cell line. RT-PCR using total RNA isolated from breast and colon cancer cell lines indicates that GC-C transcripts are undetectable in human breast cancer cell lines and abundant in human colon cancer cell lines. In vitro competitive binding studies using STh analogs and the estrogen receptor positive (ER+) T-47D cell line demonstrated IC50 values between 2.6 and 8.5 nM. Similar studies on the estrogen receptor negative (ER-) cell line MDA-MB-231 showed IC50's between 5.6 and 9.9 nM. Saturation binding analysis revealed receptor expression to fall between 40,000 and 120,000 sites per cell in these cell lines, receptor abundances equal to or greater than the abundance of GC-C in colorectal cancer cell lines. STh binding to these cells, although of similar affinity to STh binding to GC-C, is distinguishable from it on the basis of its ligand specificity. The characteristics of STh analogs as radiopharmaceutical agents were tested in an in vivo model utilizing T-47D human breast cancer cell xenografts in SCID mice. Clearance of STh analogs was rapid, primarily via renal excretion into the urine, with >85% ID excreted into the urine at 1 h p.i. Tumor uptake at 1 h p.i. in T-47D tumor cell xenografts was 0.67+/-0.23% ID/g, and was significantly decreased (p<0.05) upon co-administration of 4 mg/kg unlabeled STh. These results suggest that STh may find application for the imaging and treatment of breast cancer. JF - Breast cancer research and treatment AU - Giblin, Michael F AU - Gali, Hariprasad AU - Sieckman, Gary L AU - Owen, Nellie K AU - Hoffman, Timothy J AU - Volkert, Wynn A AU - Forte, Leonard R AD - Department of Radiology, University of Missouri-Columbia, and Research Service, Harry S. Truman Memorial Veterans' Administration Hospital, Columbia, MO 65211, USA. GiblinM@health.missouri.edu Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 7 EP - 15 VL - 98 IS - 1 SN - 0167-6806, 0167-6806 KW - Cross-Linking Reagents KW - 0 KW - Enterotoxins KW - Indium Radioisotopes KW - Index Medicus KW - Neoplasm Transplantation KW - Animals KW - Humans KW - Cross-Linking Reagents -- pharmacology KW - In Vitro Techniques KW - Mice KW - Colonic Neoplasms -- metabolism KW - Cell Line, Tumor KW - Mice, SCID KW - Inhibitory Concentration 50 KW - Protein Binding KW - Female KW - Drug Screening Assays, Antitumor KW - Escherichia coli -- metabolism KW - Enterotoxins -- therapeutic use KW - Indium Radioisotopes -- pharmacology KW - Breast Neoplasms -- therapy KW - Breast Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68624431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+and+treatment&rft.atitle=In+vitro+and+in+vivo+evaluation+of+111In-labeled+E.+coli+heat-stable+enterotoxin+analogs+for+specific+targeting+of+human+breast+cancers.&rft.au=Giblin%2C+Michael+F%3BGali%2C+Hariprasad%3BSieckman%2C+Gary+L%3BOwen%2C+Nellie+K%3BHoffman%2C+Timothy+J%3BVolkert%2C+Wynn+A%3BForte%2C+Leonard+R&rft.aulast=Giblin&rft.aufirst=Michael&rft.date=2006-07-01&rft.volume=98&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+and+treatment&rft.issn=01676806&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-11 N1 - Date created - 2006-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - PRISM-E: comparison of integrated care and enhanced specialty referral models in depression outcomes. AN - 68602816; 16816278 AB - This study, entitled Primary Care Research in Substance Abuse and Mental Health for the Elderly, examined six-month outcomes for older primary care patients with depression who received different models of treatment. Clinical outcomes were compared for patients who were randomly assigned to integrated care or enhanced specialty referral. Integrated care consisted of mental health services co-located in primary care in collaboration with primary care physicians. Enhanced specialty referral consisted of referral to physically separate, clearly identified mental health or substance abuse clinics. A total of 1,531 patients were included; their mean age was 73.9 years. Remission rates and symptom reduction for all depressive disorders were similar for the two models at the three- and six-month follow-ups. For the subgroup with major depression, the enhanced specialty referral model was associated with a greater reduction in depression severity than integrated care, but rates of remission and change in function did not differ across models of care for major depression. Six-month outcomes were comparable for the two models. For the subgroup with major depression, reduction in symptom severity was superior for those randomly assigned to the enhanced specialty referral group. JF - Psychiatric services (Washington, D.C.) AU - Krahn, Dean D AU - Bartels, Stephen J AU - Coakley, Eugenie AU - Oslin, David W AU - Chen, Hongtu AU - McIntyre, Jack AU - Chung, Henry AU - Maxwell, James AU - Ware, James AU - Levkoff, Sue E AD - Department of Psychiatry, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. dean.krahn@med.va.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 946 EP - 953 VL - 57 IS - 7 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - United States KW - Alcoholism -- rehabilitation KW - Alcoholism -- diagnosis KW - Anxiety Disorders -- psychology KW - Anxiety Disorders -- diagnosis KW - Humans KW - Aged KW - Anxiety Disorders -- rehabilitation KW - Alcoholism -- psychology KW - Comorbidity KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Hospitals, Veterans KW - Models, Organizational KW - Depressive Disorder, Major -- diagnosis KW - Patient Care Team KW - Depressive Disorder -- psychology KW - Depressive Disorder, Major -- psychology KW - Referral and Consultation KW - Depressive Disorder -- diagnosis KW - Primary Health Care KW - Depressive Disorder, Major -- rehabilitation KW - Delivery of Health Care, Integrated KW - Depressive Disorder -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68602816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=PRISM-E%3A+comparison+of+integrated+care+and+enhanced+specialty+referral+models+in+depression+outcomes.&rft.au=Krahn%2C+Dean+D%3BBartels%2C+Stephen+J%3BCoakley%2C+Eugenie%3BOslin%2C+David+W%3BChen%2C+Hongtu%3BMcIntyre%2C+Jack%3BChung%2C+Henry%3BMaxwell%2C+James%3BWare%2C+James%3BLevkoff%2C+Sue+E&rft.aulast=Krahn&rft.aufirst=Dean&rft.date=2006-07-01&rft.volume=57&rft.issue=7&rft.spage=946&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antiretroviral therapy in HIV-positive women is associated with increased apolipoproteins and total cholesterol. AN - 68591585; 16770290 AB - Dyslipidemia has become a common problem in HIV disease, especially in patients on combination antiretroviral (ARV) therapy. However, little data are available to evaluate lipid abnormalities in women on ARV therapy. Using a cross-sectional design, the prevalence of abnormal plasma lipid and lipoprotein concentrations as well as other biomarkers for vascular disease was determined in 184 HIV-positive women from 2 HIV clinics in Atlanta during 2002. Most of the women were African American (89%), with median age of 41 years (range 21-72); 6% were diabetic, 44% smoked, and 67% were overweight. ARV therapy defined the comparison groups that included treatment with a protease inhibitor (PI)-based regimen for more than 3 months in 76 (41%), treatment with a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimen for more than 3 months in 38 (20%), and no ARV therapy for the past 3 months in 70 (38%). Women being treated with a PI or NNRTI had higher total cholesterol and triglyceride levels than patients on no therapy (P < 0.05 for each). Women treated with either PIs or NNRTIs had significantly higher apolipoprotein B and apolipoprotein C-III levels than patients on no therapy (P < 0.01 for each). In this cross-sectional study of HIV-infected women, either PI or NNRTI therapy elevated levels of total cholesterol and specific apolipoproteins. These findings, on a background of an older population with additional risk factors of smoking, obesity, and diabetes, may lead to future atherosclerotic events in these patients. JF - Journal of acquired immune deficiency syndromes (1999) AU - Rimland, David AU - Guest, Jodie L AU - Hernández-Ramos, Isabel AU - Del Rio, Carlos AU - Le, N Anh AU - Brown, W Virgil AD - Atlanta VA Medical Center, Atlanta, GA 30033, USA. david.rimland@med.va.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 307 EP - 313 VL - 42 IS - 3 SN - 1525-4135, 1525-4135 KW - Anti-HIV Agents KW - 0 KW - Apolipoproteins KW - Triglycerides KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - AIDS/HIV KW - Triglycerides -- blood KW - Cross-Sectional Studies KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - CD4 Lymphocyte Count KW - Female KW - Cholesterol -- blood KW - Apolipoproteins -- blood KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- blood KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68591585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=Antiretroviral+therapy+in+HIV-positive+women+is+associated+with+increased+apolipoproteins+and+total+cholesterol.&rft.au=Rimland%2C+David%3BGuest%2C+Jodie+L%3BHern%C3%A1ndez-Ramos%2C+Isabel%3BDel+Rio%2C+Carlos%3BLe%2C+N+Anh%3BBrown%2C+W+Virgil&rft.aulast=Rimland&rft.aufirst=David&rft.date=2006-07-01&rft.volume=42&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=15254135&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-11 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Accelerated denaturation of hemoglobin and the antimalarial action of chloroquine. AN - 68576666; 16801420 AB - To study the antimalarial action of chloroquine, normal mouse erythrocytes were used as surrogates for erythrocytoid bodies. These bodies form in the endosomes of intraerythrocytic malaria parasites as they feed on their host and consist of erythrocyte cytoplasm enclosed in a vestige of the erythrocyte membrane. In suspensions of normal erythrocytes or lysates (equivalent to 5 microl of erythrocytes per ml in each case), hemoglobin underwent denaturation when it was incubated at 38 degrees C in 150 mM sodium acetate (pH 5). It is reasonable to assume that the same phenomenon occurs in acidic endosomes. Addition of 100 microM chloroquine to the incubation mixture caused the rate of hemoglobin denaturation to double to 40 nanomoles per hour per ml of packed erythrocytes. This effect required the presence of erythrocyte stroma and was inhibited by reducing the temperature to 24 degrees C or increasing the pH to 6. We propose that the primary antimalarial action of chloroquine is to bind to ferriprotoporphyrin IX (FP) and remove it from oxidized hemoglobin, thus producing toxic FP-chloroquine complexes and an excess of denatured globin. Furthermore, we suggest that these substances inhibit endosomal maturation and thereby cause hemoglobin accumulation in immature endosomes and masking of the lipids needed for FP dimerization. The term "masking" is used to signify that unsaturated lipids are present in parasitized erythrocytes but are specifically unavailable to promote FP dimerization. JF - Antimicrobial agents and chemotherapy AU - Fitch, Coy D AU - Russell, Natrice V AD - Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA. coy.fitch@va.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 2415 EP - 2419 VL - 50 IS - 7 SN - 0066-4804, 0066-4804 KW - Antimalarials KW - 0 KW - Hemoglobins KW - Hemin KW - 743LRP9S7N KW - Chloroquine KW - 886U3H6UFF KW - Index Medicus KW - Animals KW - Hydrogen-Ion Concentration KW - Temperature KW - Protein Denaturation KW - Hemolysis KW - Mice KW - Male KW - Erythrocytes -- chemistry KW - Antimalarials -- pharmacology KW - Hemoglobins -- metabolism KW - Chloroquine -- pharmacology KW - Antimalarials -- metabolism KW - Chloroquine -- metabolism KW - Hemin -- metabolism KW - Chloroquine -- therapeutic use KW - Antimalarials -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68576666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Accelerated+denaturation+of+hemoglobin+and+the+antimalarial+action+of+chloroquine.&rft.au=Fitch%2C+Coy+D%3BRussell%2C+Natrice+V&rft.aulast=Fitch&rft.aufirst=Coy&rft.date=2006-07-01&rft.volume=50&rft.issue=7&rft.spage=2415&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-30 N1 - Date created - 2006-06-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1977 Apr;59(4):633-40 [845254] Exp Parasitol. 1976 Aug;40(1):52-61 [780119] J Cell Biol. 1978 Apr;77(1):72-82 [96121] J Clin Invest. 1980 Oct;66(4):856-8 [7419723] EMBO J. 1984 Nov;3(11):2695-700 [6391917] Parasitology. 1985 Jun;90 ( Pt 3):579-88 [4011321] J Cell Biol. 1985 Dec;101(6):2302-9 [3905824] Biochem Pharmacol. 1986 Jul 15;35(14):2435-42 [3524576] Biochemistry. 1988 Aug 23;27(17):6425-34 [3219344] J Cell Sci. 1989 Apr;92 ( Pt 4):691-9 [2532219] J Biol Chem. 1992 Aug 15;267(23):16703-11 [1644843] Life Sci. 1992;51(26):2073-8 [1474861] J Cell Sci. 1993 Sep;106 ( Pt 1):237-48 [8270628] Experientia. 1994 Jan 15;50(1):34-9 [8293798] Biochim Biophys Acta. 1999 May 31;1454(1):31-7 [10354512] Mol Biochem Parasitol. 2000 Sep;110(1):107-24 [10989149] Parasitol Today. 2000 Oct;16(10):427-33 [11006474] Exp Biol Med (Maywood). 2001 Sep;226(8):746-52 [11520940] Biochem Pharmacol. 2002 Feb 1;63(3):393-8 [11853690] Trends Parasitol. 2003 Jan;19(1):23-6 [12488222] Arch Biochem Biophys. 2003 Feb 15;410(2):296-306 [12573290] J Biol Chem. 2003 Jun 20;278(25):22596-9 [12697766] Life Sci. 2004 Mar 5;74(16):1957-72 [14967191] Nature. 1967 May 27;214(5091):935-6 [4964195] Nature. 1967 May 27;214(5091):937-9 [4861556] Mil Med. 1969 Sep;134(10):825-65 [4987062] Bull World Health Organ. 1977;55(2-3):199-203 [412600] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vitro selection and in vivo efficacy of piperazine- and alkanediamide-linked bisbenzamidines against Pneumocystis pneumonia in mice. AN - 68576223; 16801410 AB - Bisbenzamidines, such as pentamidine isethionate, are aromatic dicationic compounds that are active against Pneumocystis and other microbes but are oftentimes toxic to the host. To identify potential anti-Pneumocystis agents, we synthesized bisbenzamidine derivatives in which the parent compound pentamidine was modified by a 1,4-piperazinediyl, alkanediamide, or 1,3-phenylenediamide moiety as the central linker. Several of the compounds were more active against P. carinii and less toxic than pentamidine in cytotoxicity assays. For this study, we evaluated nine bisbenzamidine derivatives representing a range of in vitro activities, from highly active to inactive, for the treatment of pneumocystosis in an immunosuppressed mouse model. Six of these in vitro-active compounds, 01, 02, 04, 06, 100, and 101, exhibited marked efficacies against infection at a dose of 10 mg/kg of body weight, and four compounds, 01, 04, 100, and 101, showed significant increases in survival versus that of untreated infected control mice. Compound 100 was highly efficacious against the infection at 20 mg/kg and 40 mg/kg, with > 1,000-fold reductions in burden, and resulted in improved survival curves versus those for pentamidine-treated mice (at the same doses). All six bisbenzamidine compounds that exhibited high in vitro activity significantly decreased the infection in vivo; two compounds, 12 and 102, with marked to moderate in vitro activities had slight or no activity in vivo, while compound 31 was inactive in vitro and was also inactive in vivo. Thus, the selection of highly active compounds from in vitro cytotoxicity assays was predictive of activity in the mouse model of Pneumocystis pneumonia. We conclude that a number of these bisbenzamidine compounds, especially compound 100, may show promise as new anti-Pneumocystis drugs. JF - Antimicrobial agents and chemotherapy AU - Cushion, Melanie T AU - Walzer, Peter D AU - Ashbaugh, Alan AU - Rebholz, Sandra AU - Brubaker, Ronald AU - Vanden Eynde, Jean Jacques AU - Mayence, Annie AU - Huang, Tien L AD - Research Service, Veterans Affairs Medical Center, Cincinnati, OH 45220, USA. melanie.cushion@med.va.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 2337 EP - 2343 VL - 50 IS - 7 SN - 0066-4804, 0066-4804 KW - Alkanes KW - 0 KW - Antifungal Agents KW - Benzamidines KW - Piperazines KW - piperazine KW - 1RTM4PAL0V KW - Pentamidine KW - 673LC5J4LQ KW - Index Medicus KW - Animals KW - Humans KW - Alkanes -- chemistry KW - Mice, Inbred C3H KW - Disease Models, Animal KW - Mice KW - Immunocompromised Host KW - Pneumocystis carinii -- drug effects KW - Male KW - Antifungal Agents -- toxicity KW - Pneumonia, Pneumocystis -- drug therapy KW - Benzamidines -- chemistry KW - Piperazines -- chemistry KW - Antifungal Agents -- therapeutic use KW - Benzamidines -- chemical synthesis KW - Benzamidines -- therapeutic use KW - Pneumonia, Pneumocystis -- mortality KW - Pneumonia, Pneumocystis -- microbiology KW - Pentamidine -- chemistry KW - Antifungal Agents -- chemical synthesis KW - Antifungal Agents -- chemistry KW - Benzamidines -- toxicity KW - Pentamidine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68576223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=In+vitro+selection+and+in+vivo+efficacy+of+piperazine-+and+alkanediamide-linked+bisbenzamidines+against+Pneumocystis+pneumonia+in+mice.&rft.au=Cushion%2C+Melanie+T%3BWalzer%2C+Peter+D%3BAshbaugh%2C+Alan%3BRebholz%2C+Sandra%3BBrubaker%2C+Ronald%3BVanden+Eynde%2C+Jean+Jacques%3BMayence%2C+Annie%3BHuang%2C+Tien+L&rft.aulast=Cushion&rft.aufirst=Melanie&rft.date=2006-07-01&rft.volume=50&rft.issue=7&rft.spage=2337&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-30 N1 - Date created - 2006-06-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bioorg Med Chem Lett. 2004 Sep 6;14(17):4545-8 [15357989] J Protozool. 1991 Nov-Dec;38(6):78S-81S [1667935] Emerg Infect Dis. 2004 Oct;10(10):1713-20 [15504255] Emerg Infect Dis. 2004 Oct;10(10):1721-8 [15504256] Emerg Infect Dis. 2004 Oct;10(10):1729-35 [15504257] Natl Cancer Inst Monogr. 1976 Oct;43:13-30 [828240] Journ Annu Diabetol Hotel Dieu. 1978;:273-9 [306470] Antimicrob Agents Chemother. 1988 Jun;32(6):896-905 [3137861] J Protozool. 1989 Jan-Feb;36(1):74S-76S [2785206] Am J Med. 1989 Sep;87(3):260-3 [2773964] Antimicrob Agents Chemother. 1992 Sep;36(9):1943-50 [1416885] Antimicrob Agents Chemother. 1993 Dec;37(12):2668-73 [8109934] J Eukaryot Microbiol. 1994 Jan-Feb;41(1):31-8 [8124264] J Clin Microbiol. 1994 Nov;32(11):2791-800 [7852574] Antimicrob Agents Chemother. 1994 Nov;38(11):2572-6 [7872750] Diabetes Care. 1995 Jan;18(1):47-55 [7698047] J Med Chem. 1995 Nov 24;38(24):4739-59 [7490723] Antimicrob Agents Chemother. 1997 Feb;41(2):251-8 [9021175] Antimicrob Agents Chemother. 1997 Feb;41(2):379-84 [9021195] Antimicrob Agents Chemother. 1998 Mar;42(3):666-74 [9517949] AIDS. 1998 May 28;12(8):873-8 [9631140] FEMS Immunol Med Microbiol. 1998 Sep;22(1-2):27-35 [9792058] J Eukaryot Microbiol. 2006 Jan-Feb;53(1):2-11 [16441572] Microbes Infect. 2000 Jan;2(1):61-7 [10717542] J Infect Dis. 2001 Mar 1;183(5):819-22 [11181161] Antimicrob Agents Chemother. 2001 Nov;45(11):3234-7 [11600389] Antimicrob Agents Chemother. 2002 Feb;46(2):514-6 [11796365] Nucleic Acids Res. 2002 Jul 1;30(13):2961-71 [12087182] Clin Infect Dis. 2003 Jan 1;36(1):70-8 [12491205] J Med Chem. 2003 Mar 13;46(6):1041-8 [12620080] Trends Parasitol. 2003 May;19(5):232-9 [12763430] J Eukaryot Microbiol. 2003;50 Suppl:624-6 [14736188] J Infect Dis. 2004 May 1;189(9):1684-7 [15116306] J Med Chem. 2004 May 6;47(10):2700-5 [15115412] Microbiology. 2004 May;150(Pt 5):1153-65 [15133075] Eur J Med Chem. 2004 Jun;39(6):547-53 [15183913] J Med Chem. 1990 Apr;33(4):1252-7 [2319567] Antimicrob Agents Chemother. 1990 Jun;34(6):1026-30 [2393262] Ann N Y Acad Sci. 1990;616:421-41 [2078033] Antimicrob Agents Chemother. 2004 Nov;48(11):4209-16 [15504843] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New-onset type-2 diabetes associated with atypical antipsychotic medications. AN - 68046585; 16581171 AB - This study compared the one-year incidence of new-onset type-2 diabetes mellitus (DM) and changes in weight in patients with a variety of psychiatric diagnoses prescribed olanzapine, risperidone, or quetiapine, compared to a reference group receiving haloperidol and no other antipsychotic medication. Data was abstracted from charts of subjects newly initiated and then maintained for one year on olanzapine (n=112), risperidone (n=100), quetiapine (n=100), and haloperidol (n=100). Baseline and one-year DM status, height, and weight were collected, as well as concurrent psychotropic medications, medical and psychiatric comorbidities. Using a multivariate model, logistic regression identified a significant association between olanzapine (but not other atypical agents) and the development of diabetes compared to haloperidol over the one-year period (odds ratio 8.4, 95% CI 1.8-38.7). Baseline obesity was independently associated with new-onset DM, but only marginally greater weight gain was found among olanzapine users. The middle-aged American veterans in this study cohort were highly vulnerable to the diabetogenic effects of olanzapine, but a close correlation with weight change was not found. Patients administered olanzapine should receive careful laboratory monitoring for elevated plasma glucose in addition to weight measurement. JF - Progress in neuro-psychopharmacology & biological psychiatry AU - Lambert, Michael T AU - Copeland, Laurel A AU - Sampson, Nancy AU - Duffy, Sonia A AD - University of Texas Southwestern Medical School at Dallas (UTSWMS), Department of Psychiatry, 5323 Harry Hines Blvd., Dallas, TX 75235-9070, and North Texas Veterans Health Care System, USA. Michael.Lambert2@med.va.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 919 EP - 923 VL - 30 IS - 5 SN - 0278-5846, 0278-5846 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Odds Ratio KW - Humans KW - Retrospective Studies KW - Aged KW - Psychotic Disorders -- epidemiology KW - Multivariate Analysis KW - Psychotic Disorders -- complications KW - Risk KW - Aged, 80 and over KW - United States Department of Veterans Affairs KW - Adult KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Male KW - Psychotic Disorders -- drug therapy KW - Diabetes Mellitus, Type 2 -- epidemiology KW - Diabetes Mellitus, Type 2 -- chemically induced KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68046585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+neuro-psychopharmacology+%26+biological+psychiatry&rft.atitle=New-onset+type-2+diabetes+associated+with+atypical+antipsychotic+medications.&rft.au=Lambert%2C+Michael+T%3BCopeland%2C+Laurel+A%3BSampson%2C+Nancy%3BDuffy%2C+Sonia+A&rft.aulast=Lambert&rft.aufirst=Michael&rft.date=2006-07-01&rft.volume=30&rft.issue=5&rft.spage=919&rft.isbn=&rft.btitle=&rft.title=Progress+in+neuro-psychopharmacology+%26+biological+psychiatry&rft.issn=02785846&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Outcomes and costs of matching the intensity of dual-diagnosis treatment to patients' symptom severity AN - 61393686; 200703311 AB - This study evaluated a patient-treatment matching strategy intended to improve the effectiveness and cost-effectiveness of acute treatment for dual-diagnosis patients. Matching variables were the severity of the patient's disorders and the program's service intensity. Patients (N = 230) with dual substance use and psychiatric disorders received low or high service-intensity acute care in 1 of 14 residential programs and were followed up for 1 year (80%) using the Addiction Severity Index. Patients' health care utilization was assessed from charts, Department of Veterans Affairs (VA) databases, and health care diaries, costs were assigned using methods established by the VA Health Economics Resource Center. High-severity patients treated in high-intensity programs had better alcohol, drug, and psychiatric outcomes at follow-up, as well as higher health care utilization and costs during the year between intake and follow-up than did those in low-intensity programs. For moderate-severity patients, high service intensity improved the effectiveness of treatment in only a single domain (drug abuse) and increased costs of the index stay but did not increase health care costs accumulated over the study year. Moderate-severity patients generally had similar outcomes and health care costs whether they were matched to low-intensity treatment or not. For high-severity patients, matching to higher service intensity improved the effectiveness of treatment as well as increased health care costs. Research is needed to establish standards by which to judge whether the added benefits of high-intensity acute care justify the extra costs. [Copyright 2006 Elsevier Inc.] JF - Journal of Substance Abuse Treatment AU - Chen, Shuo AU - Barnett, Paul G AU - Sempel, Jill M AU - Timko, Christine AD - Center for Health Care Evaluation, Department of Veterans Affairs Health Care System, Menlo Park, CA 94025, USA. Tel.: +1 650 493 5000x23336; fax +1 650 617 2736 E-mail: christine.timko@va.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 95 EP - 105 PB - Elsevier, New York NY VL - 31 IS - 1 SN - 0740-5472, 0740-5472 KW - Dual diagnosis, Patient-treatment matching, Effectiveness, Cost-effectiveness, Acute care KW - Treatment Outcomes KW - Substance Abuse KW - Treatment Programs KW - Mental Illness KW - Health Care Utilization KW - Comorbidity KW - Health Care Costs KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61393686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Outcomes+and+costs+of+matching+the+intensity+of+dual-diagnosis+treatment+to+patients%27+symptom+severity&rft.au=Chen%2C+Shuo%3BBarnett%2C+Paul+G%3BSempel%2C+Jill+M%3BTimko%2C+Christine&rft.aulast=Chen&rft.aufirst=Shuo&rft.date=2006-07-01&rft.volume=31&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/10.1016%2Fj.jsat.2006.03.015 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-08-01 N1 - Number of references - 63 N1 - Last updated - 2016-09-28 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Treatment Programs; Comorbidity; Substance Abuse; Treatment Outcomes; Health Care Utilization; Health Care Costs; Mental Illness DO - http://dx.doi.org/10.1016/j.jsat.2006.03.015 ER - TY - JOUR T1 - Association Between Alexithymia and Neuroendocrine Response to Psychological Stress in Police Academy Recruits AN - 20723851; 6983708 AB - Alexithymia has been associated with both posttraumatic stress disorder and neuroendocrine responses to stress. This study examined the relationship of alexithymia to salivary cortisol and 3-methoxy-4-hydroxy-phenylglycol (MHPG) in a sample of police academy recruits exposed to a video stress challenge. Alexithymia scores were negatively associated with catecholamine response to the video challenge but no association was found between alexithymia scores and cortisol reactivity. JF - Annals of the New York Academy of Sciences AU - McCaslin, Shannon E AU - Inslicht, Sabra S AU - Neylan, Thomas C AU - Metzler, Thomas J AU - Otte, Christian AU - Lenoci, Maryann AU - Henn-Haase, Clare AU - Best, Suzanne AU - Yehuda, Rachel AU - Marmar, Charles R AD - PTSD Research Program, University of California, San Francisco, VAMC-4150 Clement Street (116P), San Francisco, CA 94121, Shannon.McCaslin@va.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 425 EP - 427 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1071 SN - 0077-8923, 0077-8923 KW - police officers KW - CSA Neurosciences Abstracts; Health & Safety Science Abstracts KW - Emotions KW - Hydrocortisone KW - Psychology KW - Recruitment KW - Stress KW - Neuroendocrine system KW - working conditions KW - post-traumatic stress disorder KW - Posttraumatic stress disorder KW - Catecholamines KW - Occupational health KW - H 1000:Occupational Safety and Health KW - N3 11009:Neuroendocrinology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Association+Between+Alexithymia+and+Neuroendocrine+Response+to+Psychological+Stress+in+Police+Academy+Recruits&rft.au=McCaslin%2C+Shannon+E%3BInslicht%2C+Sabra+S%3BNeylan%2C+Thomas+C%3BMetzler%2C+Thomas+J%3BOtte%2C+Christian%3BLenoci%2C+Maryann%3BHenn-Haase%2C+Clare%3BBest%2C+Suzanne%3BYehuda%2C+Rachel%3BMarmar%2C+Charles+R&rft.aulast=McCaslin&rft.aufirst=Shannon&rft.date=2006-07-01&rft.volume=1071&rft.issue=&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1364.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - SuppNotes - References, 7. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Emotions; Catecholamines; Hydrocortisone; Recruitment; Stress; Neuroendocrine system; post-traumatic stress disorder; Posttraumatic stress disorder; Psychology; working conditions; Occupational health DO - http://dx.doi.org/10.1196/annals.1364.034 ER - TY - JOUR T1 - Antifungal effect of voriconazole on intracellular Candida glabrata, Candida krusei and Candida parapsilosis in human monocyte-derived macrophages AN - 19850115; 7018652 AB - Infections caused by Candida species other than Candida albicans are increasingly common, and decreased susceptibility to azoles has made them more difficult to treat. Since phagocytic killing is important in elimination of Candida infections, intracellular killing of fluconazole-resistant Candida glabrata, Candida krusei and Candida parapsilosis (four strains each) by voriconazole was investigated in human monocyte-derived macrophages (MDMs). MDMs were infected with Candida, and voriconazole was then added. MDMs were lysed at 0, 24 or 48 h after infection, and viable Candida in the lysates enumerated. Compared to the starting inoculum, the number of viable intracellular C. parapsilosis and C. glabrata in untreated MDMs increased to 28121 and 351%, respectively, in 48 h. In contrast, the number of C. krusei decreased to 42%. In MDMs treated with voriconazole, the decrease in viable count was dependent upon drug concentration. At 48 h, C. glabrata was killed only at 5 x MIC (P < 0.05), C. krusei was killed at all voriconazole concentrations, while C. parapsilosis was inhibited at 0.5 and 1 x MIC and killed at greater than or equal to 2.5 x MIC (P < 0.05). The data show that intracellular growth and survival of these Candida species in the absence or presence of voriconazole vary markedly. The activity of voriconazole depends on the concentration of the drug and the time of exposure. For the 12 Candida strains studied, regression curves show that the maximum intracellular anticandidal activity of voriconazole was reached at 3.5-5 x MIC. JF - Journal of Medical Microbiology AU - Bopp, L H AU - Baltcn, AL AU - Ritz, W J AU - Michelsen, P B AU - Smith, R P AD - Infectious Disease Research Laboratory, Stratton Veterans Affairs Medical Center, Albany, NY 12208, USA, aldona.baltch@med.va.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 865 EP - 870 VL - 55 IS - 7 SN - 0022-2615, 0022-2615 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Macrophages KW - Data processing KW - Candida glabrata KW - Survival KW - Candida albicans KW - Infection KW - Intracellular killing KW - Minimum inhibitory concentration KW - Clinical microbiology KW - Phagocytes KW - Voriconazole KW - Candida krusei KW - Inoculum KW - Candida parapsilosis KW - Monocytes KW - Drugs KW - azoles KW - A 01340:Antibiotics & Antimicrobials KW - K 03400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19850115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Microbiology&rft.atitle=Antifungal+effect+of+voriconazole+on+intracellular+Candida+glabrata%2C+Candida+krusei+and+Candida+parapsilosis+in+human+monocyte-derived+macrophages&rft.au=Bopp%2C+L+H%3BBaltcn%2C+AL%3BRitz%2C+W+J%3BMichelsen%2C+P+B%3BSmith%2C+R+P&rft.aulast=Bopp&rft.aufirst=L&rft.date=2006-07-01&rft.volume=55&rft.issue=7&rft.spage=865&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Microbiology&rft.issn=00222615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Data processing; Survival; Infection; Minimum inhibitory concentration; Intracellular killing; Clinical microbiology; Phagocytes; Voriconazole; Inoculum; Monocytes; Drugs; azoles; Candida glabrata; Candida krusei; Candida parapsilosis; Candida albicans ER - TY - JOUR T1 - Bacteroides fragilis BmeABC efflux systems additively confer intrinsic antimicrobial resistance AN - 19522452; 6995928 AB - OBJECTIVES: To determine the prevalence of expression and function(s) of Bacteroides fragilis RND family efflux transport systems (bmeABC1-16). METHODS: The mRNA transcripts of bmeB efflux pump genes were detected in a wild-type strain ADB77 by RT-PCR and expression in different strains was quantified by comparative quantitative real-time RT-PCR. In order to determine independent or additive functions, BmeB 1, 3, 12 and 15 (the first efflux pumps identified) were deleted as singles, doubles, triples or quadruples by the double cross-over technique with pADB242 and antimicrobial susceptibility was assayed by the spiral gradient endpoint technique. RESULTS: All efflux pumps except bmeB9 were expressed in the wild-type parental strain. Susceptibility to {szligbeta}-lactams, fluoroquinolones, ethidium bromide, SDS and triclosan was increased in ADB77 Delta bmeB3 (up to 3-fold) and ADB77 Delta bmeB1 Delta bmeB3 Delta bmeB12 (up to 5-fold). Expression of bmeB9 was increased and that of bmeB11 repressed in the latter deletant. A quadruple deletant (ADB77 Delta bmeB1 Delta bmeB3 Delta bmeB12 Delta bmeB15) had similar changes as well as a 2-fold increase in expression of bmeB16 and norfloxacin resistance. Expression of bmeB3 was increased in two triple deletants ADB77 Delta bmeB1 Delta bmeB12 Delta bmeB15-type I (2-fold) and ADB77 Delta bmeB1 Delta bmeB12 Delta bmeB15-type II (5.8-fold). Antimicrobial MICs were also increased in the latter deletant; ampicillin (2.6-fold), cefoperazone (3.4-fold), cefoxitin (1.8-fold), tetracycline (36.4-fold), SDS (1.7-fold) and triclosan (2-fold). CONCLUSIONS: These data demonstrate that constitutive bmeB expression is prevalent in B. fragilis. At least seven BmeB efflux pumps are functional in transporting antimicrobials and have overlapping substrate profiles, and at least four confer intrinsic resistance. JF - Journal of Antimicrobial Chemotherapy AU - Pumbwe, Lilian AU - Ueda, Ohmi AU - Yoshimura, Fuminobu AU - Chang, Abraham AU - Smith, Rachel L AU - Wexler, Hannah M AD - Greater Los Angeles Veterans Administration Healthcare Systems Los Angeles, CA, USA. Department of Medicine, University of California Los Angeles, CA, USA. Department of Oral Microbiology, Matsumoto Dental University Shiojiri, Japan. Department of Microbiology, School of Dentistry, Aichi-Gakuin University Nagoya, Japan Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 37 EP - 46 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 58 IS - 1 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Bacteroides fragilis KW - Norfloxacin KW - Data processing KW - Fluoroquinolones KW - Cefoperazone KW - Drug resistance KW - Ampicillin KW - Tetracyclines KW - Minimum inhibitory concentration KW - Ethidium bromide KW - Sodium lauryl sulfate KW - Polymerase chain reaction KW - Antimicrobial resistance KW - Cefoxitin KW - Triclosan KW - A 01340:Antibiotics & Antimicrobials KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19522452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Bacteroides+fragilis+BmeABC+efflux+systems+additively+confer+intrinsic+antimicrobial+resistance&rft.au=Pumbwe%2C+Lilian%3BUeda%2C+Ohmi%3BYoshimura%2C+Fuminobu%3BChang%2C+Abraham%3BSmith%2C+Rachel+L%3BWexler%2C+Hannah+M&rft.aulast=Pumbwe&rft.aufirst=Lilian&rft.date=2006-07-01&rft.volume=58&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Norfloxacin; Data processing; Cefoperazone; Fluoroquinolones; Drug resistance; Ampicillin; Tetracyclines; Minimum inhibitory concentration; Sodium lauryl sulfate; Ethidium bromide; Polymerase chain reaction; Antimicrobial resistance; Triclosan; Cefoxitin; Bacteroides fragilis ER - TY - JOUR T1 - The ACTH Response to Dexamethasone in Persian Gulf War Veterans AN - 19372959; 6983714 AB - The basis of postdeployment health symptoms in Gulf War veterans remains poorly understood. Alterations in the feedback regulation of the hypothalamic-pituitary-adrenal (HPA) axis have been demonstrated in posttraumatic stress disorder (PTSD) and other bodily disorders related to stress. The objective of this article was to examine whether similar HPA axis alterations are related to Gulf War deployment, postdeployment health symptoms, or PTSD. Plasma adrenocorticotropic hormone (ACTH) was measured on consecutive mornings at 08:00 h before and after a low dose of oral dexamethasone (DEX) at 23:00 h in Gulf War veterans with PTSD (n= 14), Gulf War veterans without PTSD (n= 11), and healthy veterans never deployed to a war zone (n= 12). Both Gulf War veterans with PTSD and Gulf War veterans without PTSD had significantly lower post-DEX ACTH levels than the nonexposed veterans, in the absence of group differences in basal ACTH or DEX levels. Among Gulf War veterans, post-DEX ACTH levels were significantly associated with musculoskeletal symptoms. Gulf War deployment and postdeployment health symptoms appear to be associated with alterations in feedback regulation of the pituitary gland that suggests a possible common link between postdeployment health symptoms and other chronic stress-related conditions. JF - Annals of the New York Academy of Sciences AU - Golier, Julia A AU - Legge, Juliana AU - Yehuda, Rachel AD - Bronx VA Medical Center, OOMH, 130 West Kingsbridge Road, Bronx, NY 10468. Voice: 718-584-9000; ext.: 5196, Julia.golier@med.va.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 448 EP - 453 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1071 SN - 0077-8923, 0077-8923 KW - dexamethasone KW - CSA Neurosciences Abstracts; Health & Safety Science Abstracts KW - Dexamethasone KW - posttraumatic stress disorder KW - Gulf War KW - Psychology KW - Arabian Sea, Persian Gulf KW - Stress KW - Hypothalamic-pituitary-adrenal axis KW - Hormones KW - Adrenocorticotropic hormone KW - war KW - musculoskeletal system KW - post-traumatic stress disorder KW - War KW - Pituitary KW - Feedback KW - Military KW - Military personnel KW - Occupational health KW - H 1000:Occupational Safety and Health KW - N3 11009:Neuroendocrinology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19372959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=The+ACTH+Response+to+Dexamethasone+in+Persian+Gulf+War+Veterans&rft.au=Golier%2C+Julia+A%3BLegge%2C+Juliana%3BYehuda%2C+Rachel&rft.aulast=Golier&rft.aufirst=Julia&rft.date=2006-07-01&rft.volume=1071&rft.issue=&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1364.040 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - SuppNotes - Figures, 1; tables, 1; references, 25. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Dexamethasone; Gulf War; Pituitary; War; Stress; Feedback; Hypothalamic-pituitary-adrenal axis; Adrenocorticotropic hormone; Military personnel; post-traumatic stress disorder; posttraumatic stress disorder; Psychology; Military; Hormones; musculoskeletal system; war; Occupational health; Arabian Sea, Persian Gulf DO - http://dx.doi.org/10.1196/annals.1364.040 ER - TY - JOUR T1 - Pain among Veterans of Operations Enduring Freedom and Iraqi Freedom AN - 19372329; 6983969 AB - Objective.Pain is one of the most frequently reported symptoms by veterans returning from recent overseas military actions. The purpose of the current study was to obtain a preliminary estimate of the prevalence and severity of pain among veterans of Operations Enduring Freedom and Iraqi Freedom (OEF-OIF; N = 970). The demographic, etiologic, and diagnostic characteristics of 100 veterans with moderate to severe chronic pain conditions were examined in order to provide a description of this new group of pain patients. Design.This was a historical cohort study that utilized electronic medical record review for all data collection. Patients.All registered OEF-OIF veterans seeking treatment at a Southeastern Veterans' Affairs medical center were included in the initial cohort. In order to describe the characteristics of those with clinically significant pain, 100 veterans were randomly sampled from the subset of patients who reported moderate to severe chronic pain intensity during a medical visit (N = 219). Results.Approximately 47% of veterans whose charts included pain score documentation (N = 793) reported at least a mild level of current pain. Moderate to severe pain intensity was recorded for 28% (N = 219) of those in the initial cohort with pain scores. Diagnoses of musculoskeletal and connective tissue disorders were recorded for 82% of those with chronic conditions (i.e., duration greater than or equal to 1 month). Conclusions.The results of this preliminary study suggest that a substantial percentage of OEF-OIF veterans will experience clinically significant pain following their military service. JF - Pain Medicine AU - Gironda, Ronald J AU - Clark, Michael E AU - Massengale, Jill P AU - Walker, Robyn L AD - James A. Haley Veterans' Hospital, Tampa, Florida, ronald.gironda@med.va.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 339 EP - 343 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 7 IS - 4 SN - 1526-2375, 1526-2375 KW - Health & Safety Science Abstracts KW - Historical account KW - Data collection KW - Reviews KW - pain KW - Military KW - Iraq KW - musculoskeletal system KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19372329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain+Medicine&rft.atitle=Pain+among+Veterans+of+Operations+Enduring+Freedom+and+Iraqi+Freedom&rft.au=Gironda%2C+Ronald+J%3BClark%2C+Michael+E%3BMassengale%2C+Jill+P%3BWalker%2C+Robyn+L&rft.aulast=Gironda&rft.aufirst=Ronald&rft.date=2006-07-01&rft.volume=7&rft.issue=4&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Pain+Medicine&rft.issn=15262375&rft_id=info:doi/10.1111%2Fj.1526-4637.2006.00146.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - SuppNotes - Tables, 1; references, 18. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Historical account; Data collection; Reviews; pain; Military; musculoskeletal system; Occupational health; Iraq DO - http://dx.doi.org/10.1111/j.1526-4637.2006.00146.x ER - TY - JOUR T1 - Predictors of Posttraumatic Stress in Police and Other First Responders AN - 19372060; 6983675 AB - We provide an overview of previous research conducted by our group on risk and resilience factors for PTSD symptoms in police and other first responders. Based on our work, the findings of other investigators on individual differences in risk for PTSD, and drawing on preclinical studies fear conditioning and extinction, we propose a conceptual model for the development of PTSD symptoms emphasizing the role of vulnerability and resilience to peritraumatic panic reactions. We tested this conceptual model in a cross-sectional sample of police officers (n= 715). Utilizing an hierarchical linear regression model we were able to explain 39.7% of the variance in PTSD symptoms. Five variables remained significant in the final model; greater peritraumatic distress ( beta = 0.240, P < .001), greater peritraumatic dissociation ( beta = 0.174, P < .001), greater problem-solving coping ( beta = 0.103, P < .01), greater routine work environment stress ( beta = 0.182, P < .001), and lower levels of social support ( beta =-0.246, P < .001). These results were largely consistent with the proposed conceptual model. Next steps in this line of research will be to test this model prospectively in a sample of 400 police academy recruits assessed during training and currently being followed for the first 2 years of police service. JF - Annals of the New York Academy of Sciences AU - Marmar, Charles R AU - Mccaslin, Shannon E AU - Metzler, Thomas J AU - Best, Suzanne AU - Weiss, Daniel S AU - Fagan, Jeffery AU - Liberman, Akiva AU - Pole, Nnamdi AU - Otte, Christian AU - Yehuda, Rachel AU - Mohr, David AU - Neylan, Thomas AD - San Francisco Veterans Affairs Medical Center, 4150 Clement St. , San Francisco, CA 94121, Charles.marmar@med.va.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1 EP - 18 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1071 SN - 0077-8923, 0077-8923 KW - police officers KW - Health & Safety Science Abstracts KW - posttraumatic stress disorder KW - Psychology KW - Training KW - Stress KW - working conditions KW - Occupational health KW - Emergency medical services KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19372060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Predictors+of+Posttraumatic+Stress+in+Police+and+Other+First+Responders&rft.au=Marmar%2C+Charles+R%3BMccaslin%2C+Shannon+E%3BMetzler%2C+Thomas+J%3BBest%2C+Suzanne%3BWeiss%2C+Daniel+S%3BFagan%2C+Jeffery%3BLiberman%2C+Akiva%3BPole%2C+Nnamdi%3BOtte%2C+Christian%3BYehuda%2C+Rachel%3BMohr%2C+David%3BNeylan%2C+Thomas&rft.aulast=Marmar&rft.aufirst=Charles&rft.date=2006-07-01&rft.volume=1071&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1364.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - SuppNotes - Tables, 1; formulas, 2; references, 49. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - posttraumatic stress disorder; Training; Psychology; Stress; working conditions; Emergency medical services; Occupational health DO - http://dx.doi.org/10.1196/annals.1364.001 ER - TY - JOUR T1 - Autonomic Recovery from Peak Arm Exercise in Fit and Unfit Individuals with Paraplegia AN - 19276708; 7018598 AB - Altered autonomic cardiovascular control in persons with paraplegia may reflect peripheral sympathetic denervation caused by the injury or deconditioning due to skeletal muscle paralysis. Parameters of autonomic cardiovascular control may be improved in fit persons with paraplegia similar to effects reported in the noninjured population. To determine differences in resting and recovery HR and cardiac autonomic control in fit and unfit individuals with paraplegia. Eighteen healthy males with paraplegia below T sub(6) were studied; nine participated in aerobic exercise conditioning (fit: greater than or equal to 30 min times d super(-1), greater than or equal to 3 d times wk super(-1), greater than or equal to 6 months), and nine were sedentary (unfit). Analysis of heart rate variability (HRV) was used to determine spectral power (In transformed) in the high- (lnHF) and low-frequency (lnLF) bandwidths, and the LF/HF ratio was calculated. Data were collected at baseline (BL) and at 2, 10, 30, 60, and 90 min of recovery from peak arm cycle ergometry. The relative intensity achieved on the peak exercise test was comparable between the groups (i.e., 88% peak predicted HR). However, peak watts (P < 0.001) and oxygen consumption (P < 0.01) were higher in the fit compared with the unfit group (56 and 51%, respectively). Recovery lnHF was increased (P < 0.05), and recovery lnLF (P < 0.01) and LF/HF (P < 0.05) were reduced in the fit compared with the unfit group. Mean recovery autonomic activity was not different from BL in the fit group. In the unfit group, mean recovery lnHF was reduced, and mean recovery lnLF and LF/HF remained elevated above BL. These data suggest that fit individuals with paraplegia have improved cardiac autonomic control during the postexercise recovery period compared with their unfit counterparts. JF - Medicine & Science in Sports & Exercise AU - Wecht, J M AU - Marsico, R AU - Weir, J P AU - Spungen, A M AU - Bauman, WA AU - De Meersman, RE AD - James J. Peters Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA, jm.wecht@med.va.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1223 EP - 1228 VL - 38 IS - 7 SN - 0195-9131, 0195-9131 KW - Physical Education Index KW - Oxygen consumption KW - Aerobics KW - Injuries KW - Ergometry KW - Heart rate KW - Muscles KW - Sport science KW - Health KW - Conditioning KW - Exercise (intensity) KW - Recovery KW - Analysis KW - Deconditioning KW - Cardiorespiratory KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19276708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicine+%26+Science+in+Sports+%26+Exercise&rft.atitle=Autonomic+Recovery+from+Peak+Arm+Exercise+in+Fit+and+Unfit+Individuals+with+Paraplegia&rft.au=Wecht%2C+J+M%3BMarsico%2C+R%3BWeir%2C+J+P%3BSpungen%2C+A+M%3BBauman%2C+WA%3BDe+Meersman%2C+RE&rft.aulast=Wecht&rft.aufirst=J&rft.date=2006-07-01&rft.volume=38&rft.issue=7&rft.spage=1223&rft.isbn=&rft.btitle=&rft.title=Medicine+%26+Science+in+Sports+%26+Exercise&rft.issn=01959131&rft_id=info:doi/10.1249%2F01.mss.0000227306.34149.ba LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Oxygen consumption; Injuries; Aerobics; Ergometry; Heart rate; Muscles; Sport science; Health; Conditioning; Recovery; Exercise (intensity); Analysis; Cardiorespiratory; Deconditioning DO - http://dx.doi.org/10.1249/01.mss.0000227306.34149.ba ER - TY - CPAPER T1 - Bone Density Around Endosseous Implants Determined by Quantitative Computed Tomography T2 - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AN - 40159281; 4306274 JF - 84th General Session and Exhibition of the IADR and 1st Meeting of the Pan-Asian-Pacific Federation AU - Griffiths, G Y1 - 2006/06/28/ PY - 2006 DA - 2006 Jun 28 KW - Bone density KW - Computed tomography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40159281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.atitle=Bone+Density+Around+Endosseous+Implants+Determined+by+Quantitative+Computed+Tomography&rft.au=Griffiths%2C+G&rft.aulast=Griffiths&rft.aufirst=G&rft.date=2006-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=84th+General+Session+and+Exhibition+of+the+IADR+and+1st+Meeting+of+the+Pan-Asian-Pacific+Federation&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2006Brisb/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Sleep behaviour: Sleep in continuously active dolphins; Activity and sleep in dolphins (Reply) AN - 19737409; 6907005 AB - All terrestrial mammals studied so far do maximal amounts of sleeping at birth, with sleep time gradually decreasing to adult levels. This has led to the concept that sleep, with its characteristic immobility and unresponsiveness, is necessary for brain and body development. We reported that dolphins and killer whales have a very unusual developmental pattern: neonates are maximally and continuously active at birth, and this activity diminishes over a period of months to the adult level; in the postpartum period, mothers also abruptly cease the characteristic 'hanging' that constitutes the typical sleep behaviour in bottlenose dolphins and killer whales. We did not claim that all sleep was abolished in the postpartum period. Rather, we reported that immobility was absent and that typical sleep posture increases with age, a pattern opposite to that seen in all land mammals studied so far. Sekiguchi et al. and Gnone et al. challenge our conclusions. JF - Nature AU - Lyamin, OI AU - Pryaslova, J AU - Lance, V AU - Siegel, J M AD - University of California, Los Angeles & Veterans Administration Greater Los Angeles Healthcare System, Sepulveda, California 91343, USA, jsiegel@ucla.edu Y1 - 2006/06/22/ PY - 2006 DA - 2006 Jun 22 SP - 1 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com] VL - 441 IS - 7096 SN - 0028-0836, 0028-0836 KW - Ecology Abstracts; Animal Behavior Abstracts; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - Behaviour KW - Parturition KW - Brain KW - Birth KW - Postpartum KW - Sleep KW - Marine mammals KW - Neonates KW - Cetacea KW - Posture KW - O 1070:Ecology/Community Studies KW - Y 25150:General/Miscellaneous KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08423:Behaviour UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19737409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Sleep+behaviour%3A+Sleep+in+continuously+active+dolphins%3B+Activity+and+sleep+in+dolphins+%28Reply%29&rft.au=Lyamin%2C+OI%3BPryaslova%2C+J%3BLance%2C+V%3BSiegel%2C+J+M&rft.aulast=Lyamin&rft.aufirst=OI&rft.date=2006-06-22&rft.volume=441&rft.issue=7096&rft.spage=E11&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature04900 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Marine mammals; Sleep; Behaviour; Brain; Parturition; Birth; Postpartum; Neonates; Posture; Cetacea; Marine DO - http://dx.doi.org/10.1038/nature04900 ER - TY - JOUR T1 - The Performance-Perceptual Test (PPT) and its relationship to aided reported handicap and hearing aid satisfaction. AN - 85398440; pmid-16672792 AB - Results of objective clinical tests (e.g., measures of speech understanding in noise) often conflict with subjective reports of hearing aid benefit and satisfaction. The Performance-Perceptual Test (PPT) is an outcome measure in which objective and subjective evaluations are made by using the same test materials, testing format, and unit of measurement (signal-to-noise ratio, S/N), permitting a direct comparison between measured and perceived ability to hear. Two variables are measured: a Performance Speech Reception Threshold in Noise (SRTN) for 50% correct performance and a Perceptual SRTN, which is the S/N at which listeners perceive that they can understand the speech material. A third variable is computed: the Performance-Perceptual Discrepancy (PPDIS); it is the difference between the Performance and Perceptual SRTNs and measures the extent to which listeners "misjudge" their hearing ability. Saunders et al. in 2004 examined the relation between PPT scores and unaided hearing handicap. In this publication, the relations between the PPT, residual aided handicap, and hearing aid satisfaction are described.Ninety-four individuals between the ages of 47 and 86 yr participated. All had symmetrical sensorineural hearing loss and had worn binaural hearing aids for at least 6 wk before participating. All subjects underwent routine audiological examination and completed the PPT, the Hearing Handicap Inventory for the Elderly/Adults (HHIE/A), and the Satisfaction for Amplification in Daily Life questionnaire. Sixty-five subjects attended one research visit for participation in this study, and 29 attended a second visit to complete the PPT a second time.Performance and Perceptual SRTN and PPDIS scores were normally distributed and showed excellent test-retest reliability. Aided SRTNs were significantly better than unaided SRTNs; aided and unaided PPDIS values did not differ. Stepwise multiple linear regression showed that the PPDIS, the Performance SRTN, and age were significant predictors of scores on the HHIE/A such that greater reported handicap is associated with underestimating hearing ability, poorer aided ability to understand speech in noise, and being younger. Scores on the Satisfaction with Amplification in Daily Life were not well explained by the PPT, age, or audiometric thresholds. When individuals were grouped by their HHIE/A scores, it was seen that individuals who report more handicap than expected based on their audiometric thresholds, have a more negative PPDIS, i.e., underestimate their hearing ability, relative to individuals who report expected handicap, who in turn have a more negative PPDIS than individuals who report less handicap than expected. No such patterns were apparent for the Performance SRTN.The study showed the PPT to be a reliable outcome measure that can provide more information than a performance measure and/or a questionnaire measure alone, in that the PPDIS can provide the clinician with an explanation for discrepant objective and subjective reports of hearing difficulties. The finding that self-reported handicap is affected independently by both actual ability to hear and the (mis)perception of ability to hear underscores the difficulty clinicians encounter when trying to interpret outcomes questionnaires. We suggest that this variable should be measured and taken into account when interpreting questionnaires and counseling patients. JF - Ear and hearing AU - Saunders, Gabrielle H AU - Forsline, Anna AD - National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Portland, Oregon 97207, USA. gabrielle.saunders@med.va.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 229 EP - 242 VL - 27 IS - 3 SN - 0196-0202, 0196-0202 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - Audiometry, Pure-Tone KW - Auditory Perception: physiology KW - Female KW - Hearing Aids: psychology KW - *Hearing Loss, Sensorineural: therapy KW - *Hearing Tests: methods KW - Humans KW - Male KW - Middle Aged KW - Noise: adverse effects KW - *Patient Satisfaction KW - Perceptual Masking KW - Questionnaires KW - Task Performance and Analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85398440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+hearing&rft.atitle=The+Performance-Perceptual+Test+%28PPT%29+and+its+relationship+to+aided+reported+handicap+and+hearing+aid+satisfaction.&rft.au=Saunders%2C+Gabrielle+H%3BForsline%2C+Anna&rft.aulast=Saunders&rft.aufirst=Gabrielle&rft.date=2006-06-01&rft.volume=27&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Ear+and+hearing&rft.issn=01960202&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The application of self-efficacy principles to audiologic rehabilitation: a tutorial. AN - 85396147; pmid-16803791 AB - The purpose of this tutorial is to provide a comprehensive overview of the self-efficacy framework and its application to audiologic rehabilitation.A literature review was conducted on self-efficacy and its relevance to successful interventions in several health domains. Specific recommendations were presented for audiologic rehabilitation procedures that will enhance self-efficacy.As is the case in other health domains, clinical intervention by audiologists will be more effective when incorporating a self-efficacy framework in the audiologic rehabilitation process. JF - American journal of audiology AU - Smith, Sherri L AU - West, Robin Lea AD - James H. Quillen VA Medical Center, Audiology-126, Mountain Home, TN 37684, USA. sherri.smith@med.va.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 46 EP - 56 VL - 15 IS - 1 SN - 1059-0889, 1059-0889 KW - Index Medicus KW - National Library of Medicine KW - Attitude to Health KW - *Audiology: methods KW - Audiology: standards KW - Health Behavior KW - *Hearing Aids: psychology KW - *Hearing Impaired Persons: psychology KW - Hearing Loss: psychology KW - *Hearing Loss: rehabilitation KW - Humans KW - Motivation KW - Patient Education as Topic: methods KW - Patient Education as Topic: standards KW - Quality of Life KW - Rehabilitation of Hearing Impaired: methods KW - Rehabilitation of Hearing Impaired: psychology KW - Rehabilitation of Hearing Impaired: standards KW - *Self Efficacy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+audiology&rft.atitle=The+application+of+self-efficacy+principles+to+audiologic+rehabilitation%3A+a+tutorial.&rft.au=Smith%2C+Sherri+L%3BWest%2C+Robin+Lea&rft.aulast=Smith&rft.aufirst=Sherri&rft.date=2006-06-01&rft.volume=15&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=American+journal+of+audiology&rft.issn=10590889&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Word recognition of digit triplets and monosyllabic words in multitalker babble by listeners with sensorineural hearing loss. AN - 85392982; pmid-16866003 AB - In an initial experiment (Wilson and Weakley, 2004), word recognition was assessed with six digit triplets presented at 14 signal-to-babble ratios (S/B) in 2 dB steps. An abbreviated version of the protocol was developed for clinic use involving three digit triplets at 7 S/Bs in 4 dB steps. The purpose of this experiment was to examine the relationship between the two digit protocols with comparisons made with other variables including age, pure-tone thresholds, subjective measures of understanding speech in quiet and in noise, and word recognition of monosyllabic words in quiet and in babble. Ninety-six listeners with sensorineural hearing loss participated. For equivalent performance, the short version of the digit triplets required (1) a 2.6 dB more favorable S/B than the long version and (2) a 15.1 dB less favorable S/B than the words. Age, hearing loss, and subjective evaluation of the ability to understand speech in quiet and in noise were not related to performance on digits or words in multitalker babble. JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AU - Burks, Christopher A AU - Weakley, Deborah G AD - VA Medical Center, Audiology (126), Mountain Home, TN 37684, USA. RICHARD.WILSON2@MED.VA.GOV Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 385 EP - 397 VL - 17 IS - 6 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation KW - Analysis of Variance KW - Female KW - *Hearing Loss, Sensorineural: physiopathology KW - Humans KW - Male KW - Middle Aged KW - Regression Analysis KW - *Speech Perception: physiology KW - *Speech Reception Threshold Test KW - Verbal Behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85392982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Word+recognition+of+digit+triplets+and+monosyllabic+words+in+multitalker+babble+by+listeners+with+sensorineural+hearing+loss.&rft.au=Wilson%2C+Richard+H%3BBurks%2C+Christopher+A%3BWeakley%2C+Deborah+G&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2006-06-01&rft.volume=17&rft.issue=6&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes. AN - 85392862; pmid-16892449 AB - Subthalamic nucleus (STN) deep brain stimulation (DBS) is currently the most common therapeutic surgical procedure for patients with Parkinson's disease (PD) who have failed medical management. However, a recent summary of clinical evidence on the effectiveness of STN DBS is lacking. We report the results of such a systematic review and meta-analysis. A comprehensive review of the literature using Medline and Ovid databases from 1993 until 2004 was conducted. Estimates of change in absolute Unified Parkinson's Disease Rating Scale (UPDRS) scores after surgery were generated using random-effects models. Sources of heterogeneity were explored with meta-regression models, and the possibility of publication bias was evaluated. Patient demographics, reduction in medication requirements, change in dyskinesia, daily offs, quality of life, and a ratio of postoperative improvement from stimulation compared to preoperative improvement by medication from each study were tabulated and average scores were calculated. Adverse effects from each study were summarized. Thirty-seven cohorts were included in the review. Twenty-two studies with estimates of standard errors were included in the meta-analysis. The estimated decreases in absolute UPDRS II (activities of daily living) and III (motor) scores after surgery in the stimulation ON/medication off state compared to preoperative medication off state were 13.35 (95% CI: 10.85-15.85; 50%) and 27.55 (95% CI: 24.23-30.87; 52%), respectively. Average reduction in L-dopa equivalents following surgery was 55.9% (95% CI: 50%-61.8%). Average reduction in dyskinesia following surgery was 69.1% (95% CI: 62.0%-76.2%). Average reduction in daily off periods was 68.2% (95% CI: 57.6%-78.9%). Average improvement in quality of life using PDQ-39 was 34.5% +/- 15.3%. Univariable regression showed improvements in UPDRS III scores were significantly greater in studies with higher baseline UPDRS III off scores, increasing disease duration prior to surgery, earlier year of publication, and higher baseline L-dopa responsiveness. Average baseline UPDRS III off scores were significantly lower (i.e., suggesting milder disease) in later than in earlier studies. In multivariable regression, L-dopa responsiveness, higher baseline motor scores, and disease duration were independent predictors of greater change in motor score. No evidence of publication bias in the available literature was found. The most common serious adverse event related to surgery was intracranial hemorrhage in 3.9% of patients. Psychiatric sequelae were common. Synthesis of the available literature indicates that STN DBS improves motor activity and activities of daily living in advanced PD. Differences between available studies likely reflect differences in patient populations and follow-up periods. These data provide an estimate of the magnitude of the treatment effects and emphasize the need for controlled and randomized studies. JF - Movement disorders : official journal of the Movement Disorder Society AU - Kleiner-Fisman, Galit AU - Herzog, Jan AU - Fisman, David N AU - Tamma, Filippo AU - Lyons, Kelly E AU - Pahwa, Rajesh AU - Lang, Anthony E AU - Deuschl, Günther AD - Parkinson's Disease Research Education and Clinical Center, Philadelphia VA Hospital, Philadelphia, Pennsylvania 19104, USA. galit.kleiner-fisman@med.va.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - S290 EP - S304 VL - 21 Suppl 14 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - *Deep Brain Stimulation: instrumentation KW - Dopamine Agonists: therapeutic use KW - Dyskinesias: etiology KW - Humans KW - Levodopa: therapeutic use KW - Parkinson Disease: drug therapy KW - *Parkinson Disease: therapy KW - Postoperative Complications KW - Quality of Life: psychology KW - *Subthalamic Nucleus: surgery KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85392862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Subthalamic+nucleus+deep+brain+stimulation%3A+summary+and+meta-analysis+of+outcomes.&rft.au=Kleiner-Fisman%2C+Galit%3BHerzog%2C+Jan%3BFisman%2C+David+N%3BTamma%2C+Filippo%3BLyons%2C+Kelly+E%3BPahwa%2C+Rajesh%3BLang%2C+Anthony+E%3BDeuschl%2C+G%C3%BCnther&rft.aulast=Kleiner-Fisman&rft.aufirst=Galit&rft.date=2006-06-01&rft.volume=21+Suppl+14&rft.issue=&rft.spage=S290&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Evidence based medicine (EBM) in practice: applying results of cost-effectiveness analyses. AN - 85390496; pmid-16771930 JF - The American journal of gastroenterology AU - Rubenstein, Joel H AU - Inadomi, John M AD - Division of Gastroenterology, University of Michigan School of Medicine, and Ann Arbor Veterans Administration Medical Center, Michigan 48105, USA. Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 1169 EP - 1171 VL - 101 IS - 6 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Age Factors KW - Aged KW - *Colonoscopy: economics KW - *Colorectal Neoplasms: diagnosis KW - Cost-Benefit Analysis KW - Decision Making KW - *Evidence-Based Medicine KW - Humans KW - *Mass Screening: economics KW - Middle Aged UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85390496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Evidence+based+medicine+%28EBM%29+in+practice%3A+applying+results+of+cost-effectiveness+analyses.&rft.au=Rubenstein%2C+Joel+H%3BInadomi%2C+John+M&rft.aulast=Rubenstein&rft.aufirst=Joel&rft.date=2006-06-01&rft.volume=101&rft.issue=6&rft.spage=1169&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Clinical and anatomical correlates of apraxia of speech. AN - 85386714; pmid-16516956 AB - In a previous study (Dronkers, 1996), stroke patients identified as having apraxia of speech (AOS), an articulatory disorder, were found to have damage to the left superior precentral gyrus of the insula (SPGI). The present study sought (1) to characterize the performance of patients with AOS on a classic motor speech evaluation, and (2) to examine whether severity of AOS was influenced by the extent of the lesion. Videotaped speech evaluations of stroke patients with and without AOS were reviewed by two speech-language pathologists and independently scored. Results indicated that patients with AOS made the most errors on tasks requiring the coordination of complex, but not simple, articulatory movements. Patients scored lowest on the repetition of multisyllabic words and sentences that required immediate shifting between place and manner of articulation and rapid coordination of the lips, tongue, velum, and larynx. Last, all patients with AOS had lesions in the SPGI, whereas patients without apraxia of speech did not. Additional involvement of neighboring brain areas was associated with more severe forms of both AOS as well as language deficits, such as aphasia. JF - Brain and language AU - Ogar, Jennifer AU - Willock, Sharon AU - Baldo, Juliana AU - Wilkins, David AU - Ludy, Carl AU - Dronkers, Nina AD - VA Northern California Health Care System, Martinez, CA, USA. jenny.ogar@med.va.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 343 EP - 350 VL - 97 IS - 3 SN - 0093-934X, 0093-934X KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - Apraxias: diagnosis KW - *Apraxias: physiopathology KW - Cerebral Cortex: anatomy & histology KW - Cerebral Cortex: physiopathology KW - Cerebral Cortex: radiography KW - Female KW - Humans KW - Magnetic Resonance Imaging KW - Male KW - Middle Aged KW - *Motor Cortex: anatomy & histology KW - *Motor Cortex: physiopathology KW - Motor Cortex: radiography KW - Tomography, X-Ray Computed KW - Videotape Recording UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85386714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+language&rft.atitle=Clinical+and+anatomical+correlates+of+apraxia+of+speech.&rft.au=Ogar%2C+Jennifer%3BWillock%2C+Sharon%3BBaldo%2C+Juliana%3BWilkins%2C+David%3BLudy%2C+Carl%3BDronkers%2C+Nina&rft.aulast=Ogar&rft.aufirst=Jennifer&rft.date=2006-06-01&rft.volume=97&rft.issue=3&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Brain+and+language&rft.issn=0093934X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Statin-induced myopathy: the two faces of Janus. AN - 68715808; 16891287 AB - Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) have been shown to be effective at lowering low-density lipoprotein cholesterol and decreasing the risk of coronary heart disease. Although safe and well tolerated by most patients, statins have also been associated with muscle-related adverse events. This article reviews statin-associated myotoxicity to clarify the definitions of muscle-related adverse events and discusses their incidences in major statin trials, case reports, and review articles through January 2006. Milder complaints (ie, myalgia) are reported by approximately 5% to 7% of patients who take statins. More severe myotoxicity, namely rhabdomyolysis, is extremely rare for all statins save cerivastatin, and most recent estimates of its incidence are between 0.44 and 0.54 cases per 10 000 person-years. The mechanism of statin-associated myotoxicity has not been satisfactorily defined and is likely due to multiple factors, including membrane instability, mitochondrial dysfunction, and defects in myocyte duplication. JF - Journal of cardiovascular pharmacology and therapeutics AU - Arora, Rohit AU - Liebo, Max AU - Maldonado, Frank AD - Division of Cardiovascular Disease, Department of Medicine, Chicago Medical School, 3001 Green Bay Road, North Chicago, IL 60064, USA. rohit.arora@med.va.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 105 EP - 112 VL - 11 IS - 2 SN - 1074-2484, 1074-2484 KW - Biomarkers KW - 0 KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Index Medicus KW - Risk KW - Drug Interactions KW - Humans KW - Muscular Diseases -- pathology KW - Muscular Diseases -- chemically induced KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Muscular Diseases -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68715808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.atitle=Statin-induced+myopathy%3A+the+two+faces+of+Janus.&rft.au=Arora%2C+Rohit%3BLiebo%2C+Max%3BMaldonado%2C+Frank&rft.aulast=Arora&rft.aufirst=Rohit&rft.date=2006-06-01&rft.volume=11&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.issn=10742484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-28 N1 - Date created - 2006-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ziconotide: a new option for refractory pain. AN - 68645398; 16845440 AB - Ziconotide has been introduced as a new nonopioid treatment for chronic pain. Structurally, it is a peptide, the synthetic analog of the omega-conotoxin, derived from the marine snail, Conus magus. N-type voltage-sensitive calcium channels play a role in the transmission of nociceptive stimuli and also are involved in the release of neurotransmitters important in pain transmission. Ziconotide's therapeutic benefit derives from its potent and selective blockade of neuronal-type voltage-sensitive calcium channels. Blockade of the channels results in suppression of abnormal ectopic discharges from the injury site or the dorsal root ganglia, possibly resulting in decreased neuroplasticity, and decreased synaptic transmission that leads to the generation of chronic pain syndromes. The advantage of ziconotide is that tolerance does not occur, while disadvantages associated with ziconotide are the need for intrathecal administration and significant neurotoxicites associated with its use. When tested in clinical trials, ziconotide has been shown to have synergistic or additive value to the effect of morphine. Ziconotide, formerly known also as SNX- 111, represents a new class of agents, the N-type calcium channel blockers. These may represent another option for patients with refractory pain and refractory pain syndromes. JF - Drugs of today (Barcelona, Spain : 1998) AU - Prommer, Eric AD - Division of Hematology/Oncology, Veterans Integrated Palliative Care Program, UCLA School of Medicine, Los Angeles, California 90073, USA. eric.prommer@med.va.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 369 EP - 378 VL - 42 IS - 6 SN - 1699-3993, 1699-3993 KW - Analgesics, Non-Narcotic KW - 0 KW - Calcium Channel Blockers KW - Calcium Channels KW - omega-Conotoxins KW - ziconotide KW - 7I64C51O16 KW - Index Medicus KW - Animals KW - Calcium Channels -- metabolism KW - Dose-Response Relationship, Drug KW - Humans KW - Clinical Trials as Topic KW - omega-Conotoxins -- therapeutic use KW - Pain -- drug therapy KW - Analgesics, Non-Narcotic -- pharmacology KW - Calcium Channel Blockers -- pharmacology KW - Analgesics, Non-Narcotic -- therapeutic use KW - omega-Conotoxins -- pharmacology KW - Calcium Channel Blockers -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68645398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drugs+of+today+%28Barcelona%2C+Spain+%3A+1998%29&rft.atitle=Ziconotide%3A+a+new+option+for+refractory+pain.&rft.au=Prommer%2C+Eric&rft.aulast=Prommer&rft.aufirst=Eric&rft.date=2006-06-01&rft.volume=42&rft.issue=6&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Drugs+of+today+%28Barcelona%2C+Spain+%3A+1998%29&rft.issn=16993993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Restless legs syndrome: manifestations, treatment and dental implications. AN - 68585246; 16803804 AB - The authors reviewed the clinical features, epidemiology, pathogenesis and risk factors, medical management, dental findings and dental management of patients with restless legs syndrome (RLS). The authors conducted a MEDLINE search for the years 2000 through 2004 using the key terms "restless legs syndrome," "epidemiology," "pathophysiology," "treatment" and "dentistry." They selected articles published in English in peer-reviewed journals for further review, and they gave preference to articles reporting randomized controlled trials. RLS is a neurological disorder that is characterized by unpleasant sensations in the legs that occur at rest, especially at bedtime. These symptoms cause an irresistible urge to get out of bed and move the legs to relieve the discomfort, thereby delaying sleep onset and resulting in fatigue and dysphoria the next day. The prevalence of dental disease may be extensive in patients with RLS because of diminished salivary flow resulting from the medications used to treat RLS. Patient education, saliva substitutes and anticaries agents are indicated. Special precautions must be taken when prescribing or administering sedative-hypnotic agents that are likely to have adverse reactions with the medications used to treat RLS. JF - Journal of the American Dental Association (1939) AU - Friedlander, Arthur H AU - Mahler, Michael E AU - Yagiela, John A AD - General Medical Education, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA. friedlander@med.va.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 755 EP - 761 VL - 137 IS - 6 SN - 0002-8177, 0002-8177 KW - Analgesics, Opioid KW - 0 KW - Anticonvulsants KW - Dopamine Agents KW - Hypnotics and Sedatives KW - Dentistry KW - Index Medicus KW - Humans KW - Anticonvulsants -- adverse effects KW - Dopamine Agents -- adverse effects KW - Hypnotics and Sedatives -- adverse effects KW - Analgesics, Opioid -- adverse effects KW - Dental Care for Chronically Ill KW - Restless Legs Syndrome -- drug therapy KW - Mouth Diseases -- prevention & control KW - Tooth Diseases -- prevention & control KW - Restless Legs Syndrome -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68585246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Restless+legs+syndrome%3A+manifestations%2C+treatment+and+dental+implications.&rft.au=Friedlander%2C+Arthur+H%3BMahler%2C+Michael+E%3BYagiela%2C+John+A&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2006-06-01&rft.volume=137&rft.issue=6&rft.spage=755&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-11 N1 - Date created - 2006-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diagnosis and treatment of diabetic foot infections. AN - 68570290; 16799390 AB - EXECUTIVE SUMMARY: 1. Foot infections in patients with diabetes cause substantial morbidity and frequent visits to health care professionals and may lead to amputation of a lower extremity. 2. Diabetic foot infections require attention to local (foot) and systemic (metabolic) issues and coordinated management, preferably by a multidisciplinary foot-care team (A-II). The team managing these infections should include, or have ready access to, an infectious diseases specialist or a medical microbiologist (B-II). 3. The major predisposing factor to these infections is foot ulceration, which is usually related to peripheral neuropathy. Peripheral vascular disease and various immunological disturbances play a secondary role. 4. Aerobic Gram-positive cocci (especially Staphylococcus aureus) are the predominant pathogens in diabetic foot infections. Patients who have chronic wounds or who have recently received antibiotic therapy may also be infected with Gram-negative rods, and those with foot ischemia or gangrene may have obligate anaerobic pathogens. 5. Wound infections must be diagnosed clinically on the basis of local (and occasionally systemic) signs and symptoms of inflammation. Laboratory (including microbiological) investigations are of limited use for diagnosing infection, except in cases of osteomyelitis (B-II). 6. Send appropriately obtained specimens for culture before starting empirical antibiotic therapy in all cases of infection, except perhaps those that are mild and previously untreated (B-III). Tissue specimens obtained by biopsy, ulcer curettage, or aspiration are preferable to wound swab specimens (A-I). 7. Imaging studies may help diagnose or better define deep, soft-tissue purulent collections and are usually needed to detect pathological findings in bone. Plain radiography may be adequate in many cases, but MRI (in preference to isotope scanning) is more sensitive and specific, especially for detection of soft-tissue lesions (A-I). 8. Infections should be categorized by their severity on the basis of readily assessable clinical and laboratory features (B-II). Most important among these are the specific tissues involved, the adequacy of arterial perfusion, and the presence of systemic toxicity or metabolic instability. Categorization helps determine the degree of risk to the patient and the limb and, thus, the urgency and venue of management. 9. Available evidence does not support treating clinically uninfected ulcers with antibiotic therapy (D-III). Antibiotic therapy is necessary for virtually all infected wounds, but it is often insufficient without appropriate wound care. 10. Select an empirical antibiotic regimen on the basis of the severity of the infection and the likely etiologic agent(s) (B-II). Therapy aimed solely at aerobic Gram-positive cocci may be sufficient for mild-to-moderate infections in patients who have not recently received antibiotic therapy (A-II). Broad-spectrum empirical therapy is not routinely required but is indicated for severe infections, pending culture results and antibiotic susceptibility data (B-III). Take into consideration any recent antibiotic therapy and local antibiotic susceptibility data, especially the prevalence of methicillin-resistant S. aureus (MRSA) or other resistant organisms. Definitive therapy should be based on both the culture results and susceptibility data and the clinical response to the empirical regimen (C-III). 11. There is only limited evidence with which to make informed choices among the various topical, oral, and parenteral antibiotic agents. Virtually all severe and some moderate infections require parenteral therapy, at least initially (C-III). Highly bioavailable oral antibiotics can be used in most mild and in many moderate infections, including some cases of osteomyelitis (A-II). Topical therapy may be used for some mild superficial infections (B-I). 12. Continue antibiotic therapy until there is evidence that the infection has resolved but not necessarily until a wound has healed. Suggestions for the duration of antibiotic therapy are as follows: for mild infections, 12 weeks usually suffices, but some require an additional 12 weeks; for moderate and severe infections, usually 24 weeks is sufficient, depending on the structures involved, the adequacy of debridement, the type of soft-tissue wound cover, and wound vascularity (A-II); and for osteomyelitis, generally at least 46 weeks is required, but a shorter duration is sufficient if the entire infected bone is removed, and probably a longer duration is needed if infected bone remains (B-II). 13. If an infection in a clinically stable patient fails to respond to 1 antibiotic courses, consider discontinuing all antimicrobials and, after a few days, obtaining optimal culture specimens (C-III). 14. Seek surgical consultation and, when needed, intervention for infections accompanied by a deep abscess, extensive bone or joint involvement, crepitus, substantial necrosis or gangrene, or necrotizing fasciitis (A-II). Evaluating the limb's arterial supply and revascularizing when indicated are particularly important. Surgeons with experience and interest in the field should be recruited by the foot-care team, if possible. 15. Providing optimal wound care, in addition to appropriate antibiotic treatment of the infection, is crucial for healing (A-I). This includes proper wound cleansing, debridement of any callus and necrotic tissue, and, especially, off-loading of pressure. There is insufficient evidence to recommend use of a specific wound dressing or any type of wound healing agents or products for infected foot wounds. 16. Patients with infected wounds require early and careful follow-up observation to ensure that the selected medical and surgical treatment regimens have been appropriate and effective (B-III). 17. Studies have not adequately defined the role of most adjunctive therapies for diabetic foot infections, but systematic reviews suggest that granulocyte colony-stimulating factors and systemic hyperbaric oxygen therapy may help prevent amputations (B-I). These treatments may be useful for severe infections or for those that have not adequately responded to therapy, despite correcting for all amenable local and systemic adverse factors. 18. Spread of infection to bone (osteitis or osteomyelitis) may be difficult to distinguish from noninfectious osteoarthropathy. Clinical examination and imaging tests may suffice, but bone biopsy is valuable for establishing the diagnosis of osteomyelitis, for defining the pathogenic organism(s), and for determining the antibiotic susceptibilities of such organisms (B-II). 19. Although this field has matured, further research is much needed. The committee especially recommends that adequately powered prospective studies be undertaken to elucidate and validate systems for classifying infection, diagnosing osteomyelitis, defining optimal antibiotic regimens in various situations, and clarifying the role of surgery in treating osteomyelitis (A-III). JF - Plastic and reconstructive surgery AU - Lipsky, Benjamin A AU - Berendt, Anthony R AU - Deery, H Gunner AU - Embil, John M AU - Joseph, Warren S AU - Karchmer, Adolf W AU - LeFrock, Jack L AU - Lew, Daniel P AU - Mader, Jon T AU - Norden, Carl AU - Tan, James S AU - Infectious Diseases Society of America AD - Medical Service, Veterans Affairs Puget Sound Health Care System, and Division of General Internal Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Wash 98108-9804, USA. Benjamin.Lipsky@med.va.gov ; Infectious Diseases Society of America Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 212S EP - 238S VL - 117 IS - 7 Suppl UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68570290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plastic+and+reconstructive+surgery&rft.atitle=Diagnosis+and+treatment+of+diabetic+foot+infections.&rft.au=Lipsky%2C+Benjamin+A%3BBerendt%2C+Anthony+R%3BDeery%2C+H+Gunner%3BEmbil%2C+John+M%3BJoseph%2C+Warren+S%3BKarchmer%2C+Adolf+W%3BLeFrock%2C+Jack+L%3BLew%2C+Daniel+P%3BMader%2C+Jon+T%3BNorden%2C+Carl%3BTan%2C+James+S%3BInfectious+Diseases+Society+of+America&rft.aulast=Lipsky&rft.aufirst=Benjamin&rft.date=2006-06-01&rft.volume=117&rft.issue=7+Suppl&rft.spage=212S&rft.isbn=&rft.btitle=&rft.title=Plastic+and+reconstructive+surgery&rft.issn=1529-4242&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-29 N1 - Date created - 2006-06-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Reprint Of: Clin Infect Dis. 2004 Oct 1;39(7):885-910 [15472838] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quality improvement case study: warfarin sodium interactions. AN - 68063202; 16765868 AB - Dangerous Interactions Involving Antibiotic Use In Warfarin-Treated Nursing Facility Residents FACTS OF THE INCIDENT: All names, places and dates and some details have been changed to protect the confidentiality of this actual event. JF - Journal of the American Medical Directors Association AU - Weinberg, Andrew D AU - Altman, Julie S AU - Pals, Jean K AD - University of South Carolina School of Medicine, Columbia, SC, USA. andrew.weinberg@med.va.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 315 EP - 318 VL - 7 IS - 5 SN - 1525-8610, 1525-8610 KW - Anti-Infective Agents, Urinary KW - 0 KW - Anticoagulants KW - Warfarin KW - 5Q7ZVV76EI KW - Trimethoprim, Sulfamethoxazole Drug Combination KW - 8064-90-2 KW - Prothrombin KW - 9001-26-7 KW - Index Medicus KW - Malpractice -- legislation & jurisprudence KW - Organizational Policy KW - Humans KW - International Normalized Ratio KW - Aged KW - Trimethoprim, Sulfamethoxazole Drug Combination -- adverse effects KW - Drug Therapy, Combination KW - Accidental Falls KW - Anti-Infective Agents, Urinary -- adverse effects KW - Risk Management -- organization & administration KW - Intracranial Hemorrhages -- chemically induced KW - Drug Monitoring KW - Prothrombin -- analysis KW - Drug Synergism KW - Confusion -- chemically induced KW - Female KW - Nursing Homes -- organization & administration KW - Anticoagulants -- adverse effects KW - Geriatrics -- organization & administration KW - Warfarin -- adverse effects KW - Total Quality Management -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68063202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Directors+Association&rft.atitle=Quality+improvement+case+study%3A+warfarin+sodium+interactions.&rft.au=Weinberg%2C+Andrew+D%3BAltman%2C+Julie+S%3BPals%2C+Jean+K&rft.aulast=Weinberg&rft.aufirst=Andrew&rft.date=2006-06-01&rft.volume=7&rft.issue=5&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Directors+Association&rft.issn=15258610&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vancomycin-induced elevation of liver enzyme levels. AN - 68053012; 16720708 AB - To report a case of oral vancomycin-induced elevation of liver enzyme levels. A 57-year-old man with multiple medical conditions requiring systemic antibiotic therapy developed numerous Clostridium difficile-associated enterocolitis episodes. The patient did not respond adequately to oral metronidazole, as evidenced by his continuing diarrhea. He was treated with oral vancomycin on 5 separate occasions (with doses from 125 to 500 mg/day), each of which resulted in significant elevations in alanine aminotransferase (to 371 U/L) and aspartate aminotransferase (to 203 U/L) levels. The elevations resolved on each occasion with discontinuation of vancomycin. Vancomycin, a glycopeptide antibiotic, has primary activity against gram-positive bacteria. Oral vancomycin can be used for the treatment of C. difficile-associated enterocolitis in patients who fail to respond to or are intolerant to metronidazole therapy. Oral vancomycin has very poor bioavailability and, as of May 4, 2006, has not been associated with hepatic toxicity. Inflammatory bowel disease processes can result in increased absorption of oral vancomycin. This is the first reported case of oral vancomycin-induced elevation of hepatic enzyme levels. Use of the Naranjo probability scale indicated that this was a probable adverse drug-associated event. JF - The Annals of pharmacotherapy AU - Cadle, Richard M AU - Mansouri, Mohammad D AU - Darouiche, Rabih O AD - Pharmacy Service and Section of Infectious Diseases, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA. cadle.richardmark@med.va.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1186 EP - 1189 VL - 40 IS - 6 SN - 1060-0280, 1060-0280 KW - Anti-Bacterial Agents KW - 0 KW - Metronidazole KW - 140QMO216E KW - Vancomycin KW - 6Q205EH1VU KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Humans KW - Drug Resistance KW - Diarrhea -- microbiology KW - Liver Function Tests KW - Enterocolitis, Pseudomembranous -- microbiology KW - Enterocolitis, Pseudomembranous -- drug therapy KW - Aspartate Aminotransferases -- blood KW - Alanine Transaminase -- blood KW - Metronidazole -- therapeutic use KW - Diarrhea -- drug therapy KW - Middle Aged KW - Male KW - Clostridium difficile -- drug effects KW - Enterocolitis, Pseudomembranous -- complications KW - Anti-Bacterial Agents -- therapeutic use KW - Vancomycin -- adverse effects KW - Liver -- enzymology KW - Anti-Bacterial Agents -- adverse effects KW - Vancomycin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68053012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Vancomycin-induced+elevation+of+liver+enzyme+levels.&rft.au=Cadle%2C+Richard+M%3BMansouri%2C+Mohammad+D%3BDarouiche%2C+Rabih+O&rft.aulast=Cadle&rft.aufirst=Richard&rft.date=2006-06-01&rft.volume=40&rft.issue=6&rft.spage=1186&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-23 N1 - Date created - 2006-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of serious mental illness and substance abuse on criminal offenses. AN - 68041676; 16754769 AB - Some believe serious mental illness has been "criminalized." Effects of serious mental illness and substance abuse on criminal offenses were studied for 113 postbooking jail diversion participants and their nondiverted counterparts. Raters read participants' and police report descriptions of criminal offenses and participants' explanations for them. Using 5-point scales, raters independently estimated whether an offense resulted directly or indirectly from serious mental illness or substance abuse. Serious mental illness and substance abuse had little effect on offenses. However, substance abuse led to a sizable minority of offenses and was more likely than mental illness to cause an offense. Unless factors unique to serious mental illness can be specifically associated with behavior leading to incarceration, the criminalization hypothesis should be reconsidered in favor of more powerful risk factors for crime that are widespread in social settings of persons with serious mental illness. JF - Psychiatric services (Washington, D.C.) AU - Junginger, John AU - Claypoole, Keith AU - Laygo, Ranilo AU - Crisanti, Annette AD - Mental Health Clinical Center, Department of Veterans Affairs, 10 North Greene Street, Suite 6A, Baltimore, Maryland 21201, USA. john.junginger@med.va.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 879 EP - 882 VL - 57 IS - 6 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Severity of Illness Index KW - Demography KW - Humans KW - Hawaii -- epidemiology KW - Adult KW - Male KW - Female KW - Mental Disorders -- epidemiology KW - Crime -- statistics & numerical data KW - Mental Disorders -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68041676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Effects+of+serious+mental+illness+and+substance+abuse+on+criminal+offenses.&rft.au=Junginger%2C+John%3BClaypoole%2C+Keith%3BLaygo%2C+Ranilo%3BCrisanti%2C+Annette&rft.aulast=Junginger&rft.aufirst=John&rft.date=2006-06-01&rft.volume=57&rft.issue=6&rft.spage=879&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-31 N1 - Date created - 2006-06-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Psychiatr Serv. 2006 Oct;57(10):1511-2; author reply 1512 [17035577] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Advances in environmental and occupational disorders. AN - 68041655; 16750999 AB - As with the previous year, 2005 was a very active year for investigation of the effect of environmental agents on allergic disease, be they allergens, pollutants, bioaerosols, or occupationally encountered agents. There were a large number of articles on the prevalence of allergic disease in the United States, identification and characterization of a number of allergens, and the role of indoor allergens and potential mitigation of the effect of such allergens, as well as the hygiene hypothesis, air pollution, and the effect of these agents on airway disease. The Journal of Allergy and Clinical Immunology also saw very interesting case reports and mechanistic studies examining the causes of occupational immune-mediated disease. There were also reports on gene-environment interactions, highlighting the importance of such interactions in modulating the risk for development of allergic disease. That these interactions have proved to be remarkably complex comes as no surprise to the allergy and immunology community because allergists and immunologists have long appreciated the role of environmental influences on disease. JF - The Journal of allergy and clinical immunology AU - Bush, Robert K AU - Peden, David B AD - Section of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin, Madison, WI53705, USA. Robert.Bush@med.va.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 1367 EP - 1373 VL - 117 IS - 6 SN - 0091-6749, 0091-6749 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Hypersensitivity -- epidemiology KW - Hypersensitivity -- immunology KW - Animals KW - Mycoses -- immunology KW - Mycoses -- prevention & control KW - Humans KW - Mycoses -- microbiology KW - Mycoses -- epidemiology KW - Hypersensitivity -- prevention & control KW - Hypersensitivity -- microbiology KW - Forecasting KW - Occupational Diseases -- immunology KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- microbiology KW - Environmental Pollution -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68041655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Advances+in+environmental+and+occupational+disorders.&rft.au=Bush%2C+Robert+K%3BPeden%2C+David+B&rft.aulast=Bush&rft.aufirst=Robert&rft.date=2006-06-01&rft.volume=117&rft.issue=6&rft.spage=1367&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-19 N1 - Date created - 2006-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of chronic alcohol dependence and chronic cigarette smoking on cerebral perfusion: a preliminary magnetic resonance study. AN - 68026661; 16737452 AB - Although approximately 80% of individuals with alcohol use disorders are chronic smokers and despite reported associations between chronic cigarette smoking and lower cerebral perfusion in nonalcoholics, previous brain perfusion studies with alcoholics did not account for the potential effects of concurrent chronic cigarette smoking. One-week-abstinent alcohol-dependent individuals in treatment (ALC) [19 smokers (sALC) and 10 nonsmokers (nsALC)] and 19 healthy light drinking, nonsmoking control participants (nsLD) were scanned with a pulsed arterial spin labeling method to measure cerebral perfusion without an exogenous contrast agent. Studies were performed with 2 different postlabeling delay times (time from labeling pulse to the excitation pulse; PLD=1,500 ms and PLD=1,200 ms) to assess the potential effect of arterial blood transit time on the perfusion. Average gray matter (GM) and white matter (WM) perfusion for the frontal and parietal lobes were calculated for each hemisphere from voxels containing at least 90% GM and 100% WM. At PLD=1,500 ms, multivariate analyses compared ALC (combined sALC and nsALC) with nsLD (p=0.04) and contrasted sALC, nsALC, and nsLD (p=0.006). ALC, as a group, showed 13% lower frontal GM perfusion (p=0.005) and 8% lower parietal GM perfusion than nsLD (p=0.03). With ALC separated into smokers and nonsmokers, sALC showed 19% lower frontal GM perfusion (p=0.001) and 12% lower parietal GM perfusion than nsLD (p=0.004). In sALC, a higher number of cigarettes smoked per day was associated with lower perfusion. Overall, regional perfusion did not differ significantly between nsALC and nsLD. Results obtained with PLD=1,200 ms generally confirmed the 1,500 ms findings. This study provides preliminary evidence that chronic cigarette smoking adversely affects cerebral perfusion in frontal and parietal GM of 1-week-abstinent alcohol-dependent individuals. These results are in line with our spectroscopic and structural magnetic resonance studies that suggest chronic cigarette smoking compounds the detrimental effects of alcohol dependence on brain neurobiology. JF - Alcoholism, clinical and experimental research AU - Gazdzinski, Stefan AU - Durazzo, Timothyc AU - Jahng, Geon-Ho AU - Ezekiel, Frank AU - Banys, Peter AU - Meyerhoff, Dieterj AD - Magnetic Resonance Unit, San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA. spg@itsa.ucsf.edu Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 947 EP - 958 VL - 30 IS - 6 SN - 0145-6008, 0145-6008 KW - gamma-Glutamyltransferase KW - EC 2.3.2.2 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Aspartate Aminotransferases -- blood KW - Analysis of Variance KW - Alanine Transaminase -- blood KW - Humans KW - Adult KW - gamma-Glutamyltransferase -- blood KW - Middle Aged KW - Male KW - Female KW - Cognition KW - Brain -- blood supply KW - Smoking -- adverse effects KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68026661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Effects+of+chronic+alcohol+dependence+and+chronic+cigarette+smoking+on+cerebral+perfusion%3A+a+preliminary+magnetic+resonance+study.&rft.au=Gazdzinski%2C+Stefan%3BDurazzo%2C+Timothyc%3BJahng%2C+Geon-Ho%3BEzekiel%2C+Frank%3BBanys%2C+Peter%3BMeyerhoff%2C+Dieterj&rft.aulast=Gazdzinski&rft.aufirst=Stefan&rft.date=2006-06-01&rft.volume=30&rft.issue=6&rft.spage=947&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-05 N1 - Date created - 2006-06-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Alcohol Clin Exp Res. 1994 Aug;18(4):867-72 [7978097] Alcohol Clin Exp Res. 1995 Jun;19(3):666-73 [7573791] Acta Neurol Belg. 1995;95(3):164-9 [7484053] Arch Gen Psychiatry. 2002 Sep;59(9):794-800 [12215078] J Neurol Sci. 2002 Dec 15;205(1):15-20 [12409178] Arch Gen Psychiatry. 2002 Dec;59(12):1162-72 [12470133] J Am Geriatr Soc. 2002 Dec;50(12):2105-7 [12473037] Magn Reson Med. 2003 Feb;49(2):307-14 [12541251] Am J Psychiatry. 2003 Feb;160(2):323-33 [12562580] Neuropsychopharmacology. 2003 Apr;28(4):765-72 [12655323] Br J Addict. 1989 Nov;84(11):1353-7 [2597811] West J Med. 1990 May;152(5):531-7 [2190421] Ear Nose Throat J. 1990 Nov;69(11):763-5 [2276350] Ann Neurol. 1990 Dec;28(6):775-85 [2285264] Eur J Nucl Med. 1997 Apr;24(4):422-7 [9096094] Brain. 1997 Jul;120 ( Pt 7):1173-97 [9236630] J Addict Dis. 1997;16(3):19-24 [9243336] J Psychiatr Res. 1997 Jul-Aug;31(4):393-432 [9352470] J Subst Abuse Treat. 1997 Nov-Dec;14(6):521-7 [9437623] Biol Psychiatry. 1998 Jun 15;43(12):923-8 [9627750] J Neurol Sci. 1999 Jan 1;162(1):51-5 [10064168] Med Hypotheses. 1999 Feb;52(2):101-9 [10340289] Ann N Y Acad Sci. 1999 Jun 29;877:614-37 [10415674] Radiother Oncol. 2004 Dec;73(3):367-71 [15588884] Alcohol Clin Exp Res. 2004 Dec;28(12):1849-60 [15608601] Magn Reson Med. 2005 Mar;53(3):511-8 [15723393] Radiology. 2005 Mar;234(3):851-9 [15734937] Psychiatry Res. 2005 Feb 28;138(2):115-30 [15766635] Alcohol Clin Exp Res. 2005 Aug;29(8):1484-95 [16131857] Alcohol Clin Exp Res. 2006 Mar;30(3):539-51 [16499496] J Psychiatr Res. 2006 Aug;40(5):404-18 [15979645] Trends Pharmacol Sci. 2002 Feb;23(2):78-82 [11830264] Magn Reson Med. 2000 Feb;43(2):244-50 [10680688] Alcohol Alcohol. 2000 Mar-Apr;35(2):171-5 [10787393] Free Radic Biol Med. 2000 Jul 15;29(2):115-24 [10980400] Neuroscience. 2000;101(2):277-82 [11074150] Drug Alcohol Depend. 2001 Aug 1;63(3):277-86 [11418232] Alcohol Alcohol. 2001 Jul-Aug;36(4):346-8 [11468137] Neuroimage. 2001 Jul;14(1 Pt 1):7-20 [11525339] JAMA. 2001 Nov 7;286(17):2120-7 [11694153] Alcohol Alcohol. 2001 Nov-Dec;36(6):556-63 [11704622] Cardiovasc Res. 2002 Feb 15;53(3):568-76 [11861027] Sleep Breath. 2002 Mar;6(1):19-24 [11917260] Monaldi Arch Chest Dis. 2001 Dec;56(6):545-54 [11980288] Alcohol Alcohol. 2002 Jul-Aug;37(4):347-54 [12107037] Psychiatry Res. 2002 Oct 1;115(3):115-25 [12208489] Radiology. 2003 Apr;227(1):129-35 [12616005] Neuroimage. 2003 Aug;19(4):1510-20 [12948707] Alcohol Alcohol. 2003 Nov-Dec;38(6):606-12 [14633650] Psychol Med. 2003 Nov;33(8):1357-67 [14672244] Prog Neuropsychopharmacol Biol Psychiatry. 2004 Mar;28(2):319-27 [14751429] Eur Respir J. 2004 Feb;23(2):214-8 [14979494] Biomed Pharmacother. 2004 Mar;58(2):77-83 [14992787] Int J Clin Pharmacol Ther. 2004 Feb;42(2):83-92 [15180168] Respir Med. 2004 Jun;98(6):551-6 [15191041] Arch Neurol. 1976 AUG;33(8):523-6 [942309] J Stud Alcohol. 1982 Nov;43(11):1157-70 [7182675] J Am Geriatr Soc. 1983 Jul;31(7):412-6 [6863792] JAMA. 1983 Nov 25;250(20):2796-800 [6644957] Acta Psychiatr Scand. 1987 Feb;75(2):202-8 [3565066] J Stud Alcohol. 1988 May;49(3):225-32 [3374136] Gerontology. 1988;34(4):199-204 [3181770] J Clin Exp Neuropsychol. 1991 Nov;13(6):933-49 [1779032] Clin Nucl Med. 1992 Feb;17(2):123-7 [1563181] Am J Psychiatry. 1992 Aug;149(8):1016-22 [1636801] J Nucl Med. 1993 Sep;34(9):1452-9 [8355063] Am J Psychiatry. 1994 Feb;151(2):178-83 [8296885] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suicide attempts among substance use disorder patients: an initial step toward a decision tree for suicide management. AN - 68026359; 16737458 AB - Little empirical data are available to develop profiles of patients who attempt suicide or to formulate a decision tree for suicide management. This study identifies profiles of patients who have a high risk of suicide attempt and takes a first step toward developing a decision tree to classify high-risk patients. Based on a cross-sectional, nationwide cohort of substance use disorder patients (N=34,251) in 150 Veterans Affairs (VA) facilities, a total of 5,671 patients who reported suicidal ideation in the 30 days before intake assessment were included in receiver operating characteristic (ROC) analyses to identify the 30-day risk of an actual suicide attempt. Clinical diagnostic and Addiction Severity Index interview data were used. Results provide an initial decision tree to classify high-risk patients with sensitivity ranging from 0.33 to 0.89, and specificity, from 0.42 to 0.87. The factors included in the decision tree encompass history of prior suicide attempts, current drinking to intoxication, current cocaine use, first occasion of suicidal ideation, and difficulty controlling violent behavior. To our knowledge, this is the first attempt to use empirical data to provide information to eventually establish a decision tree for clinical management of patients with suicidal ideation. The findings show that profiles of patients who are at high risk of suicide attempts can be effectively identified using ROC, with relatively good sensitivity and specificity. JF - Alcoholism, clinical and experimental research AU - Tiet, Quyen Q AU - Ilgen, Mark A AU - Byrnes, Hilary F AU - Moos, Rudolf H AD - Center for Health Care Evaluation, VA Palo Alto Health Care System, Menlo Park, California 94025, USA. Quyen.Tiet@va.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 998 EP - 1005 VL - 30 IS - 6 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - United States KW - Cocaine-Related Disorders KW - Sensitivity and Specificity KW - ROC Curve KW - Humans KW - Alcoholic Intoxication KW - Violence KW - Cross-Sectional Studies KW - United States Department of Veterans Affairs KW - Risk Factors KW - Adult KW - Cohort Studies KW - Middle Aged KW - Female KW - Male KW - Suicide, Attempted -- statistics & numerical data KW - Decision Trees KW - Substance-Related Disorders -- complications KW - Suicide, Attempted -- classification KW - Suicide -- prevention & control KW - Suicide -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68026359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Suicide+attempts+among+substance+use+disorder+patients%3A+an+initial+step+toward+a+decision+tree+for+suicide+management.&rft.au=Tiet%2C+Quyen+Q%3BIlgen%2C+Mark+A%3BByrnes%2C+Hilary+F%3BMoos%2C+Rudolf+H&rft.aulast=Tiet&rft.aufirst=Quyen&rft.date=2006-06-01&rft.volume=30&rft.issue=6&rft.spage=998&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-05 N1 - Date created - 2006-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A practical system for monitoring the outcomes of substance use disorder patients. AN - 67997167; 16716849 AB - Outcomes monitoring and management are receiving mounting attention because of increased emphasis on health care accountability and cost containment. Efficient, practical outcomes monitoring systems (OMSs) are crucial if health care system performance is to be determined and effective/cost-effective treatments are to be identified, but such practical monitoring systems generally are lacking. This article describes the features of such a system for monitoring the care received by, and the substance use and psychosocial outcomes of, patients treated for substance use disorders (SUDs) in the Department of Veterans Affairs (VA). In contrast to a 15-21% follow-up rate achieved by VA SUD program staff under a previously mandated system-wide monitoring system, the monitoring system used in this project achieved a 67% follow-up rate without paying patients for their participation. We provide data on patient characteristics and treatment outcomes, estimate the cost of implementing this type of monitoring system on a broad scale, and provide recommendations for OMSs in other large health care organizations. JF - Journal of substance abuse treatment AU - Tiet, Quyen Q AU - Byrnes, Hilary F AU - Barnett, Paul AU - Finney, John W AD - Department of Veterans Affairs Palo Alto Health Care System, Center for Health Care Evaluation, Menlo Park, CA 94025, USA. quyen.tiet@va.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 337 EP - 347 VL - 30 IS - 4 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - United States KW - United States Department of Veterans Affairs KW - Humans KW - Adult KW - Pilot Projects KW - Follow-Up Studies KW - Adolescent KW - Substance-Related Disorders -- therapy KW - Outcome Assessment (Health Care) -- methods KW - Veterans -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67997167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=A+practical+system+for+monitoring+the+outcomes+of+substance+use+disorder+patients.&rft.au=Tiet%2C+Quyen+Q%3BByrnes%2C+Hilary+F%3BBarnett%2C+Paul%3BFinney%2C+John+W&rft.aulast=Tiet&rft.aufirst=Quyen&rft.date=2006-06-01&rft.volume=30&rft.issue=4&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-20 N1 - Date created - 2006-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development and validation of a psychiatric case-mix system. AN - 67983396; 16708006 AB - Although difficulties in applying risk-adjustment measures to mental health populations are increasingly evident, a model designed specifically for patients with psychiatric disorders has never been developed. Our objective was to develop and validate a case-mix classification system, the "PsyCMS," for predicting concurrent and future mental health (MH) and substance abuse (SA) healthcare costs and utilization. Subjects included 914,225 veterans who used Veterans Administration (VA) healthcare services during fiscal year 1999 (FY99) with any MH/SA diagnosis (International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9-CM] codes 290.00-312.99, 316.00-316.99). We derived diagnostic categories from ICD-CM codes using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition definitions, clinical input, and empiric analyses. Weighted least-squares regression models were developed for concurrent (FY99) and prospective (FY00) MH/SA costs and utilization. We compared the predictive ability of the PsyCMS with several case-mix systems, including adjusted clinical groups, diagnostic cost groups, and the chronic illness and disability payment system. Model performance was evaluated using R-squares and mean absolute prediction errors (MAPEs). Patients with MH/SA diagnoses comprised 29.6% of individuals seen in the VA during FY99. The PsyCMS accounted for a distinct proportion of the variance in concurrent and prospective MH/SA costs (R=0.11 and 0.06, respectively), outpatient MH/SA utilization (R=0.25 and 0.07), and inpatient MH/SA utilization (R=0.13 and 0.05). The PsyCMS performed better than other case-mix systems examined with slightly higher R-squares and lower MAPEs. The PsyCMS has clinically meaningful categories, demonstrates good predictive ability for modeling concurrent and prospective MH/SA costs and utilization, and thus represents a useful method for predicting mental health costs and utilization. JF - Medical care AU - Sloan, Kevin L AU - Montez-Rath, Maria E AU - Spiro, Avron AU - Christiansen, Cindy L AU - Loveland, Susan AU - Shokeen, Priti AU - Herz, Lawrence AU - Eisen, Susan AU - Breckenridge, James N AU - Rosen, Amy K AD - VA Puget Sound Health Care System, and the Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98108-1597, USA. Kevin.Sloan@med.va.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 568 EP - 580 VL - 44 IS - 6 SN - 0025-7079, 0025-7079 KW - Index Medicus KW - Veterans KW - Substance-Related Disorders -- therapy KW - Humans KW - Aged KW - Models, Statistical KW - Middle Aged KW - Substance-Related Disorders -- economics KW - Male KW - Female KW - Risk Adjustment -- statistics & numerical data KW - Mental Disorders -- therapy KW - Health Services -- utilization KW - Mental Disorders -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67983396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Development+and+validation+of+a+psychiatric+case-mix+system.&rft.au=Sloan%2C+Kevin+L%3BMontez-Rath%2C+Maria+E%3BSpiro%2C+Avron%3BChristiansen%2C+Cindy+L%3BLoveland%2C+Susan%3BShokeen%2C+Priti%3BHerz%2C+Lawrence%3BEisen%2C+Susan%3BBreckenridge%2C+James+N%3BRosen%2C+Amy+K&rft.aulast=Sloan&rft.aufirst=Kevin&rft.date=2006-06-01&rft.volume=44&rft.issue=6&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-27 N1 - Date created - 2006-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - National Veterans Health Administration hospitalizations for syncope compared to acute myocardial infarction, fracture, or pneumonia in community-dwelling elders: outpatient medication and comorbidity profiles. AN - 67981338; 16707407 AB - The authors used 2 national Veterans Health Administration databases to identify outpatient medications and all 30 Elixhauser comorbidities for 2579 unique patients, age 65+ years, hospitalized for syncope in fiscal year 2004. For comparison, we identified other elderly patients hospitalized with acute myocardial infarction (N = 4491), fracture (N = 2797), or pneumonia (N = 9473). The categories of medications included drugs that affect the cardiovascular, central nervous, or the muscular skeletal system. The most notable differences between syncope compared to acute myocardial infarction patients occurred in central nervous system drugs in anticonvulsants/barbiturates, antidepressants, antihistamine/antinauseants, antipsychotics, and cholinesterase inhibitors (P < .0018). Comparing syncope patients with fracture patients, the central nervous medication profile was similar, but the cardiovascular medication profile differed (P < .0018); their hypertension comorbidities also differed (60.45% vs 46.34%); (P < .0016). These findings indicate significant potential associations that warrant further study. Studies linking national outpatient medications to hospitalizations for specific conditions can foster the development of more proactive pharmacovigilance systems. JF - Journal of clinical pharmacology AU - French, Dustin D AU - Campbell, Robert AU - Spehar, Andrea AU - Rubenstein, Laurence Z AU - Accomando, John AU - Cunningham, Francesca AD - VISN-8 Patient Safety Center, 13000 Bruce B. Downs Blvd. (118M), Tampa, FL 33612, USA. Dustin.French@med.va.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 613 EP - 619 VL - 46 IS - 6 SN - 0091-2700, 0091-2700 KW - Cardiovascular Agents KW - 0 KW - Central Nervous System Agents KW - Index Medicus KW - United States KW - Outpatients KW - Cardiovascular Agents -- adverse effects KW - United States Department of Veterans Affairs KW - Humans KW - Central Nervous System Agents -- adverse effects KW - Aged KW - Residence Characteristics KW - Hospitalization -- statistics & numerical data KW - Comorbidity KW - Fractures, Bone -- drug therapy KW - Fractures, Bone -- epidemiology KW - Syncope -- epidemiology KW - Pneumonia -- drug therapy KW - Syncope -- drug therapy KW - Pneumonia -- epidemiology KW - Myocardial Infarction -- epidemiology KW - Myocardial Infarction -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67981338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=National+Veterans+Health+Administration+hospitalizations+for+syncope+compared+to+acute+myocardial+infarction%2C+fracture%2C+or+pneumonia+in+community-dwelling+elders%3A+outpatient+medication+and+comorbidity+profiles.&rft.au=French%2C+Dustin+D%3BCampbell%2C+Robert%3BSpehar%2C+Andrea%3BRubenstein%2C+Laurence+Z%3BAccomando%2C+John%3BCunningham%2C+Francesca&rft.aulast=French&rft.aufirst=Dustin&rft.date=2006-06-01&rft.volume=46&rft.issue=6&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-06 N1 - Date created - 2006-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. AN - 67955246; 16439473 AB - The objective of this study was to determine whether Toll-like receptor 4 (TLR4) has a role in alcohol-mediated acetaminophen (APAP) hepatotoxicity. TLR4 is involved in the inflammatory response to endotoxin. Others have found that ethanol-mediated liver disease is decreased in C3H/HeJ mice, which have a mutated TLR4 resulting in a decreased response to endotoxin compared with endotoxin-responsive mice. In the present study, short-term (1 wk) pretreatment with ethanol plus isopentanol, the predominant alcohols in alcoholic beverages, caused no histologically observed liver damage in either C3H/HeJ mice or endotoxin-responsive C3H/HeN mice, despite an increase in nitrotyrosine levels in the livers of C3H/HeN mice. In C3H/HeN mice pretreated with the alcohols, subsequent exposure to APAP caused a transient decrease in liver nitrotyrosine formation, possibly due to competitive interaction of peroxynitrite with APAP producing 3-nitroacetaminophen. Treatment with APAP alone resulted in steatosis in addition to congestion and necrosis in both C3H/HeN and C3H/HeJ mice, but the effects were more severe in endotoxin-responsive C3H/HeN mice. In alcohol-pretreated endotoxin-responsive C3H/HeN mice, subsequent exposure to APAP resulted in further increases in liver damage, including severe steatosis, associated with elevated plasma levels of TNF-alpha. In contrast, alcohol pretreatment of C3H/HeJ mice caused little to no increase in APAP hepatotoxicity and no increase in plasma TNF-alpha. Portal blood endotoxin levels were very low and were not detectably elevated by any of the treatments. In conclusion, this study implicates a role of TLR4 in APAP-mediated hepatotoxicity. JF - American journal of physiology. Gastrointestinal and liver physiology AU - Yohe, Herbert C AU - O'Hara, Kimberley A AU - Hunt, Jane A AU - Kitzmiller, Tamar J AU - Wood, Sheryl G AU - Bement, Jenna L AU - Bement, William J AU - Szakacs, Juliana G AU - Wrighton, Steven A AU - Jacobs, Judith M AU - Kostrubsky, Vsevolod AU - Sinclair, Peter R AU - Sinclair, Jacqueline F AD - Veterans Administration Medical Center, White River Junction, VT 05009, USA. herbert.c.yohe@dartmouth.edu Y1 - 2006/06// PY - 2006 DA - June 2006 SP - G1269 EP - G1279 VL - 290 IS - 6 SN - 0193-1857, 0193-1857 KW - Analgesics, Non-Narcotic KW - 0 KW - Tlr4 protein, mouse KW - Toll-Like Receptor 4 KW - Acetaminophen KW - 362O9ITL9D KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Analgesics, Non-Narcotic -- adverse effects KW - Mice KW - Drug Synergism KW - Female KW - Ethanol -- adverse effects KW - Liver -- pathology KW - Fatty Liver -- chemically induced KW - Liver -- drug effects KW - Fatty Liver -- metabolism KW - Acetaminophen -- adverse effects KW - Liver -- metabolism KW - Toll-Like Receptor 4 -- metabolism KW - Fatty Liver -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67955246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.atitle=Involvement+of+Toll-like+receptor+4+in+acetaminophen+hepatotoxicity.&rft.au=Yohe%2C+Herbert+C%3BO%27Hara%2C+Kimberley+A%3BHunt%2C+Jane+A%3BKitzmiller%2C+Tamar+J%3BWood%2C+Sheryl+G%3BBement%2C+Jenna+L%3BBement%2C+William+J%3BSzakacs%2C+Juliana+G%3BWrighton%2C+Steven+A%3BJacobs%2C+Judith+M%3BKostrubsky%2C+Vsevolod%3BSinclair%2C+Peter+R%3BSinclair%2C+Jacqueline+F&rft.aulast=Yohe&rft.aufirst=Herbert&rft.date=2006-06-01&rft.volume=290&rft.issue=6&rft.spage=G1269&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.issn=01931857&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-08 N1 - Date created - 2006-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gender in Suicide Attempt Rates and Childhood Sexual Abuse Rates: Is There an Interaction? AN - 61672839; 200717692 AB - Two competing explanations for higher rates of attempted suicide in women than men were compared. Because childhood sexual abuse is more prevalent in girls than boys, one explanation of higher rates of suicide attempts in women is that it is a direct result of the higher incidence of sexual abuse in girls. Alternatively, higher rates of suicide attempts might result from gender differences in the impact of childhood sexual abuse on suicidal behavior. To compare these theories, data from 1,889 abstinent, substance-dependent patients who completed the Childhood Trauma Questionnaire (CTQ) and who were interviewed about suicide attempts was examined. Scores on each scale of the CTQ were examined as a function of gender and attempter status. Results showed higher rates of suicide attempts in women than in men, higher CTQ scores in women than men, and a higher CTQ score in attempters than nonattempters. However, logistic regression indicated that gender and abuse did not interact to determine attempter status. Thus, the data support the first hypothesis that the greater frequency of suicide attempts in women may be partly attributed to the higher prevalence of childhood sexual abuse in girls. The generalizability of these results to the general population and to other diagnostic groups requires further study. Adapted from the source document. JF - Suicide and Life-Threatening Behavior AU - Roy, Alec AU - Janal, Malvin AD - Department of Veterans Affairs, New Jersey Healthcare System, East Orange E-mail: Alec.Roy@med.va.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 329 EP - 335 PB - Guilford Publications, New York NY VL - 36 IS - 3 SN - 0363-0234, 0363-0234 KW - Sex Differences KW - Suicide KW - Child Sexual Abuse KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61672839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Suicide+and+Life-Threatening+Behavior&rft.atitle=Gender+in+Suicide+Attempt+Rates+and+Childhood+Sexual+Abuse+Rates%3A+Is+There+an+Interaction%3F&rft.au=Roy%2C+Alec%3BJanal%2C+Malvin&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2006-06-01&rft.volume=36&rft.issue=3&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Suicide+and+Life-Threatening+Behavior&rft.issn=03630234&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-08-02 N1 - Number of references - 29 N1 - Last updated - 2016-09-28 N1 - CODEN - SLBEDP N1 - SubjectsTermNotLitGenreText - Suicide; Sex Differences; Child Sexual Abuse ER - TY - JOUR T1 - Variations in Provider Conceptions of Integrative Medicine AN - 60016642; 200624523 AB - Consumers often turn to complementary & alternative medicine (CAM) & use it concurrently with conventional medicine to treat illnesses & promote wellness. However, prior studies demonstrate that these two paradigms are often not combined effectively. Consumers often do not tell physicians about CAM treatments or CAM practitioners about conventional treatments that they are using. This can lead to inefficient care &/or adverse interactions. There is also a lack of consensus about the structure & practice of integrative medicine among the various types of practitioners. This qualitative study aimed to identify key domains & develop a conceptual model of integrative medicine at the provider level, using a grounded theory approach. Purposive sampling was used to select 50 practitioners, including acupuncturists, chiropractors, internists/family practitioners, & physician acupuncturists in private practice & at academic medical centers in Los Angeles. We conducted semi-structured, in-depth interviews with practitioners & then identified core statements that describe practitioners' attitudes & behaviors toward integrative medicine. Core statements were free pile sorted to ascertain key domains of integrative medicine. Four key domains of integrative medicine were identified at the provider level: attitudes, knowledge, referral, & practice. Provider age, training, & practice setting also emerged as important factors in determining clinicians' "orientation" toward integrative medicine. "Dual-trained" practitioners, such as physician acupuncturists, exemplified clinicians with a greater orientation toward integrative medicine. They advocated an open-minded perspective about other healing traditions, promoting co-management with & making referrals to practitioners of other paradigms, & treating patients with both CAM & conventional healing modalities. Tables, Figures, References. [Copyright 2005 Elsevier Ltd.] JF - Social Science & Medicine AU - Hsiao, An-Fu AU - Ryan, Gery W AU - Hays, Ronald D AU - Coulter, Ian D AU - Andersen, Ronald M AU - Wenger, Neil S AD - VA Long Beach Healthcare System, CA anfu.hsiao@med.va.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 2973 EP - 2987 PB - Elsevier Science, Amsterdam The Netherlands VL - 62 IS - 12 SN - 0277-9536, 0277-9536 KW - Integrative medicine KW - Complementary and alternative medicine KW - CAM providers KW - Qualitative KW - Interview KW - USA KW - Alternative Medicine KW - Paradigms KW - Consumers KW - Health Care Services KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60016642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Variations+in+Provider+Conceptions+of+Integrative+Medicine&rft.au=Hsiao%2C+An-Fu%3BRyan%2C+Gery+W%3BHays%2C+Ronald+D%3BCoulter%2C+Ian+D%3BAndersen%2C+Ronald+M%3BWenger%2C+Neil+S&rft.aulast=Hsiao&rft.aufirst=An-Fu&rft.date=2006-06-01&rft.volume=62&rft.issue=12&rft.spage=2973&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2005.11.056 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Number of references - 35 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Health Care Services; Alternative Medicine; Paradigms; Consumers DO - http://dx.doi.org/10.1016/j.socscimed.2005.11.056 ER - TY - JOUR T1 - Transcriptional Induction of the Pseudomonas aeruginosa Type III Secretion System by Low Ca super(2+) and Host Cell Contact Proceeds through Two Distinct Signaling Pathways AN - 19962742; 6946976 AB - The opportunistic pathogen Pseudomonas aeruginosa utilizes a type III secretion system (T3SS) to intoxicate eukaryotic host cells. Transcription of the T3SS is induced under calcium-limited growth conditions or following intimate contact of P. aeruginosa with host cells. In the present study, we demonstrate that expression of the T3SS is controlled by two distinct regulatory mechanisms and that these mechanisms are differentially activated in a host cell-dependent manner. The first mechanism is dependent upon ExsC, a regulatory protein that couples transcription of the T3SS to the activity of the type III secretion machinery. ExsC is essential for induction of the T3SS under low-calcium-growth conditions and for T3SS-dependent cytotoxicity towards social amoebae, insect cells, and erythrocytes. The second regulatory mechanism functions independently of ExsC and is sufficient to elicit T3SS-dependent cytotoxicity towards certain types of mammalian cells. Although this second pathway (ExsC independent) is sufficient, an exsC mutant demonstrates a lag in the induction of cytotoxicity towards Chinese hamster ovary cells and is attenuated for virulence in a mouse pneumonia model. We propose that the ExsC-dependent pathway is required for full cytotoxicity towards all host cell types tested whereas the ExsC-independent pathway may represent an adaptation that allows P. aeruginosa to increase expression of the T3SS in response to specific types of mammalian cells. JF - Infection and Immunity AU - Dasgupta, Nandini AU - Ashare, Alix AU - Hunninghake, Gary W AU - Yahr, Timothy L AD - Departments of Microbiology. Internal Medicine, University of Iowa, Iowa City, Iowa 52242. the Veterans' Administration Medical Center, Iowa City, Iowa Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 3334 EP - 3341 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 6 SN - 0019-9567, 0019-9567 KW - mice KW - Entomology Abstracts; Immunology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Adaptations KW - Calcium KW - Growth conditions KW - Erythrocytes KW - Animal models KW - Transcription KW - Pathogens KW - Opportunist infection KW - Virulence KW - Cytotoxicity KW - regulatory proteins KW - Mammalian cells KW - Insect cells KW - Pseudomonas aeruginosa KW - Pneumonia KW - Signal transduction KW - Z 05300:General KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19962742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Transcriptional+Induction+of+the+Pseudomonas+aeruginosa+Type+III+Secretion+System+by+Low+Ca+super%282%2B%29+and+Host+Cell+Contact+Proceeds+through+Two+Distinct+Signaling+Pathways&rft.au=Dasgupta%2C+Nandini%3BAshare%2C+Alix%3BHunninghake%2C+Gary+W%3BYahr%2C+Timothy+L&rft.aulast=Dasgupta&rft.aufirst=Nandini&rft.date=2006-06-01&rft.volume=74&rft.issue=6&rft.spage=3334&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Calcium; Adaptations; Growth conditions; Erythrocytes; Animal models; Transcription; Pathogens; Opportunist infection; Virulence; Cytotoxicity; Mammalian cells; regulatory proteins; Insect cells; Pneumonia; Signal transduction; Pseudomonas aeruginosa ER - TY - JOUR T1 - Basis for the Failure of Francisella tularensis Lipopolysaccharide To Prime Human Polymorphonuclear Leukocytes AN - 17221177; 6946970 AB - Francisella tularensis is the intracellular gram-negative coccobacillus that causes tularemia, and its virulence and infectiousness make it a potential agent of bioterrorism. Previous studies using mononuclear leukocytes have shown that the lipopolysaccharide (LPS) of F. tularensis is neither a typical proinflammatory endotoxin nor an endotoxin antagonist. This inertness suggests that F. tularensis LPS does not bind host LPS-sensing molecules such as LPS-binding protein (LBP). Using priming of the polymorphonuclear leukocyte (PMN) oxidase as a measure of endotoxicity, we found that F. tularensis live vaccine strain LPS did not behave like either a classic endotoxin or an endotoxin antagonist in human PMNs, even when the concentration of LBP was limiting. Furthermore, F. tularensis LPS did not compete with a radiolabeled lipooligosaccharide from Neisseria meningitidis for binding to LBP or to the closely related PMN granule protein, bactericidal/permeability-increasing protein. Our results suggest that the inertness of F. tularensis LPS and the resistance of F. tularensis to oxygen-independent PMN killing may result from the inability of F. tularensis LPS to be recognized by these important LPS-sensing molecules of the innate immune system. JF - Infection and Immunity AU - Barker, Jason H AU - Weiss, Jerrold AU - Apicella, Michael A AU - Nauseef, William M AD - Inflammation Program and Department of Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa and Veterans Administration Medical Center. Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 3277 EP - 3284 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 6 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Endotoxins KW - Leukocytes (mononuclear) KW - bioterrorism KW - Leukocytes (polymorphonuclear) KW - Francisella tularensis KW - Neisseria meningitidis KW - Inflammation KW - Lipooligosaccharides KW - Tularemia KW - Gram-negative bacteria KW - LPS-binding protein KW - Lipopolysaccharides KW - Vaccines KW - F 06106:Bacteria KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17221177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Basis+for+the+Failure+of+Francisella+tularensis+Lipopolysaccharide+To+Prime+Human+Polymorphonuclear+Leukocytes&rft.au=Barker%2C+Jason+H%3BWeiss%2C+Jerrold%3BApicella%2C+Michael+A%3BNauseef%2C+William+M&rft.aulast=Barker&rft.aufirst=Jason&rft.date=2006-06-01&rft.volume=74&rft.issue=6&rft.spage=3277&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Endotoxins; Leukocytes (mononuclear); Tularemia; bioterrorism; Gram-negative bacteria; Leukocytes (polymorphonuclear); LPS-binding protein; Lipopolysaccharides; Vaccines; Lipooligosaccharides; Inflammation; Francisella tularensis; Neisseria meningitidis ER - TY - CPAPER T1 - Esophageal and Gastric Pressures During Cough in Persons with Tetraplegia T2 - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AN - 40092173; 4275475 JF - 53rd Annual Meeting of the American College of Sports Medicine (ACSM 2006) AU - Schilero, Gregory J AU - Wecht, Jill M AU - Weir, Joseph P AU - Bauman, William A Y1 - 2006/05/31/ PY - 2006 DA - 2006 May 31 KW - Pressure KW - Cough KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40092173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.atitle=Esophageal+and+Gastric+Pressures+During+Cough+in+Persons+with+Tetraplegia&rft.au=Schilero%2C+Gregory+J%3BWecht%2C+Jill+M%3BWeir%2C+Joseph+P%3BBauman%2C+William+A&rft.aulast=Schilero&rft.aufirst=Gregory&rft.date=2006-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+College+of+Sports+Medicine+%28ACSM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={560D9D66 -1842-45D5-B76C-58B247ADD44E}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Response to Methadone Maintenance Treatment of Opiate Dependent Patients with and without Significant Pain AN - 57186697; 200610897 AB - Background: Both clinicians & researchers have expressed doubt that opiate dependent patients with significant pain can be effectively treated in methadone maintenance treatment (MMT) programs; however, little research exists on this topic. Patients who report significant pain in the month preceding entry to MMT present with a distinct & more severe pattern of polysubstance use, medical & psychosocial problems than do those without pain. The present study investigated the 1-year treatment outcomes of MMT patients with opiate dependence & pain. Methods: Analyses were based on a national sample of 200 patients presenting in MMT programs for treatment of opiate dependence. Substance use & related problems were measured at treatment entry & 12 months later. Patients reported pain severity over the month preceding treatment entry. Results: Compared to patients without significant pain, patients who reported significant pain at baseline (n = 103) showed similar substance-related functioning, but poorer psychosocial functioning at 1 year. Conclusions: Patients with & without significant pain experience comparable reductions in substance use when provided with standard care in MMT programs. However, additional medical &/or mental health treatment is needed for their pain & other problems. 2 Tables, 20 References. [Copyright 2005 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Ilgen, Mark A AU - Trafton, Jodie A AU - Humphreys, Keith AD - Dept Veterans Affairs Palo Alto Health Care System, Center Health Care Evaluation, Stanford U School Medicin mark.ilgen@med.va.gov Y1 - 2006/05/20/ PY - 2006 DA - 2006 May 20 SP - 187 EP - 193 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 82 IS - 3 SN - 0376-8716, 0376-8716 KW - Pain KW - Methadone maintenance KW - Substance use KW - Treatment KW - Opiate dependence KW - Methadone KW - Opiates KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57186697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Response+to+Methadone+Maintenance+Treatment+of+Opiate+Dependent+Patients+with+and+without+Significant+Pain&rft.au=Ilgen%2C+Mark+A%3BTrafton%2C+Jodie+A%3BHumphreys%2C+Keith&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2006-05-20&rft.volume=82&rft.issue=3&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2005.09.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-07-28 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Methadone; Substance abuse; Pain; Opiates DO - http://dx.doi.org/10.1016/j.drugalcdep.2005.09.005 ER - TY - CPAPER T1 - Efficacy of Aripiprazole in Highly Agitated Patients with Psychosis of Alzheimers Disease T2 - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AN - 40074163; 4278573 JF - 61st Annual Convention and Scientific Program of the Society of Biological Psychiatry AU - Mintzer, Jacobo E AU - Crandall, David AU - Pultz, Joseph AU - Carson, William AU - Gutierrez-Esteinou, Rolando AU - Whitehead, Richard AU - Breader, Christopher Y1 - 2006/05/18/ PY - 2006 DA - 2006 May 18 KW - Neurodegenerative diseases KW - Alzheimer's disease KW - Psychosis KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40074163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.atitle=Efficacy+of+Aripiprazole+in+Highly+Agitated+Patients+with+Psychosis+of+Alzheimers+Disease&rft.au=Mintzer%2C+Jacobo+E%3BCrandall%2C+David%3BPultz%2C+Joseph%3BCarson%2C+William%3BGutierrez-Esteinou%2C+Rolando%3BWhitehead%2C+Richard%3BBreader%2C+Christopher&rft.aulast=Mintzer&rft.aufirst=Jacobo&rft.date=2006-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Convention+and+Scientific+Program+of+the+Society+of+Biological+Psychiatry&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={F7F4134E -570F-4853-BAB0-69D52F24DB5F}&AKey={FAC598DF-6BB8-4F90-B2DC-BC7CC481 998B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - "Vascular Depression" Predicts Verbal Fluency in Older Adults AN - 85663247; 200701851 AB - Past research has found links among cerebrovascular risk factors (CVRFs), depression, & cognition in older adults. This study investigated how well baseline cerebrovascular burden & depression predicted verbal fluency three & six months later. Participants were 139 medical rehabilitation patients, age 60 & above. The Geriatric Depression Scale, Charlson Co-Morbidity Index, & Dementia Rating Scale were administered at baseline, & verbal fluency was measured three & six months later. Structural equation modeling found that depression significantly predicted verbal fluency at both time points, independently of demographic variables, baseline cognition, or medical burden. CVRFs correlated with depressive symptoms but did not independently predict verbal fluency. Findings suggest that vascular depression may be a possible signal of impaired brain integrity, consistent with Alexopoulos & colleague's (2000) conceptual framework. Tables, Figures, References. Adapted from the source document JF - Journal of Clinical and Experimental Neuropsychology AU - Yochim, Brian P AU - MacNeill, Susan E AU - Lichtenberg, Peter A AD - VA Northern California Healthcare System, Martinez Brian.Yochim@va.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 495 EP - 508 VL - 28 IS - 4 SN - 1380-3395, 1380-3395 KW - Cognitive Processes (12950) KW - Elderly (21350) KW - Anatomical Systems (02750) KW - Emotional Disturbances (21570) KW - Rating Scales (70250) KW - Executive Function (23470) KW - Brain (09350) KW - Recovery (Medical) (71880) KW - Dementia (18020) KW - Fluency (24910) KW - article KW - 6610: mental retardation; mental retardation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85663247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+and+Experimental+Neuropsychology&rft.atitle=%22Vascular+Depression%22+Predicts+Verbal+Fluency+in+Older+Adults&rft.au=Yochim%2C+Brian+P%3BMacNeill%2C+Susan+E%3BLichtenberg%2C+Peter+A&rft.aulast=Yochim&rft.aufirst=Brian&rft.date=2006-05-01&rft.volume=28&rft.issue=4&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+and+Experimental+Neuropsychology&rft.issn=13803395&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2007-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCENE8 N1 - SubjectsTermNotLitGenreText - Anatomical Systems (02750); Brain (09350); Fluency (24910); Elderly (21350); Emotional Disturbances (21570); Dementia (18020); Cognitive Processes (12950); Recovery (Medical) (71880); Rating Scales (70250); Executive Function (23470) ER - TY - JOUR T1 - The long-term natural history of gastroesophageal reflux disease. AN - 85389839; pmid-16721220 AB - Long-term gastric acid suppression has been suggested as a means to prevent complications of reflux esophagitis. We report on the 20-year follow-up of 2,306 patients with at least two endoscopic examinations who were taking no antisecretory medication before baseline endoscopy and whose long-term treatment was determined by reflux symptoms.From 1979 through 1998, endoscopy and biopsy were performed in the Hines Veterans Affairs Hospital endoscopy clinic by three endoscopists. Antireflux treatment was symptom-driven, and endoscopies were repeated mostly for symptomatic recurrence due to cessation of therapy.Of 4,633 patients undergoing endoscopy for reflux symptoms, 2,306 had at least one follow-up endoscopy and biopsy. Over a mean follow-up period of 7.6 years (range, 1-20 years), the esophageal mucosa of 67% of patients remained unchanged, that of 21% improved, and that of 11% worsened. Esophageal stricture requiring dilation developed from a normal baseline mucosa in one of 1,313 patients (0.08%) and from an erosive baseline mucosa in 18 of 957 patients (1.9%). The overall incidence of stricture in patients with gastroesophageal reflux (GER) disease was <1/1,000 per year. Nonsteroidal anti-inflammatory drug (NSAID) consumption was associated with less mucosal improvement (odds ration [OR] = 0.67; confidence interval [CI] = 0.46-0.98). Use of histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) was associated with mucosal improvement (OR for PPIs = 1.49; CI = 1.14-2.17). Cohn's kappa was 42%, confirming the results that demonstrate stability of esophageal mucosal disease in the majority of patients.Symptom-driven treatment of GER disease after a thorough endoscopic examination to exclude premalignant or malignant esophageal mucosal disease is practical and safe for the vast majority of patients with uncomplicated GER symptoms. JF - Journal of clinical gastroenterology AU - Sontag, Stephen J AU - Sonnenberg, Amnon AU - Schnell, Thomas G AU - Leya, Jack AU - Metz, Adrienne AD - Hines Veterans Affairs Hospital, Hines, IL 60141, USA. Stephen.Sontag@med.va.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 398 EP - 404 VL - 40 IS - 5 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Anti-Inflammatory Agents, Non-Steroidal: adverse effects KW - Chi-Square Distribution KW - Chronic Disease KW - Disease Progression KW - Esophageal Neoplasms: pathology KW - *Esophagoscopy KW - Female KW - *Gastroesophageal Reflux: diagnosis KW - Gastroesophageal Reflux: drug therapy KW - *Gastroesophageal Reflux: physiopathology KW - Histamine H2 Antagonists: therapeutic use KW - Humans KW - Male KW - Severity of Illness Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85389839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=The+long-term+natural+history+of+gastroesophageal+reflux+disease.&rft.au=Sontag%2C+Stephen+J%3BSonnenberg%2C+Amnon%3BSchnell%2C+Thomas+G%3BLeya%2C+Jack%3BMetz%2C+Adrienne&rft.aulast=Sontag&rft.aufirst=Stephen&rft.date=2006-05-01&rft.volume=40&rft.issue=5&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: J Clin Gastroenterol. 2006 May-Jun;40(5):374-5[16721215] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - PTSD and substance-related problems: the mediating roles of disconstraint and negative emotionality. AN - 68026199; 16737401 AB - The authors examined competing hypotheses regarding the role of 2 personality dimensions, disconstraint and negative emotionality, in mediating the relationship between posttraumatic stress disorder (PTSD) severity and substance-related problems. Data were drawn from a large sample of male Vietnam veterans. The best-fitting structural model included significant indirect paths from PTSD to both alcohol- and drug-related outcomes through disconstraint, and a significant indirect path from PTSD to alcohol-related problems through negative emotionality. There were no direct effects of PTSD on either substance-related outcome. These findings indicate distinct pathways to different forms of substance-related problems in PTSD and underscore the role of personality in mediating these relationships. JF - Journal of abnormal psychology AU - Miller, Mark W AU - Vogt, Dawne S AU - Mozley, Susannah L AU - Kaloupek, Danny G AU - Keane, Terence M AD - National Center for PTSD, VA Boston Healthcare System, Boston, MA 02130, USA. mark.miller5@va.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 369 EP - 379 VL - 115 IS - 2 SN - 0021-843X, 0021-843X KW - Index Medicus KW - Humans KW - MMPI KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Affect KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68026199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+abnormal+psychology&rft.atitle=PTSD+and+substance-related+problems%3A+the+mediating+roles+of+disconstraint+and+negative+emotionality.&rft.au=Miller%2C+Mark+W%3BVogt%2C+Dawne+S%3BMozley%2C+Susannah+L%3BKaloupek%2C+Danny+G%3BKeane%2C+Terence+M&rft.aulast=Miller&rft.aufirst=Mark&rft.date=2006-05-01&rft.volume=115&rft.issue=2&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Journal+of+abnormal+psychology&rft.issn=0021843X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-12 N1 - Date created - 2006-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Catecholamine response to methamphetamine is related to glucocorticoid levels but not to pleasurable subjective response. AN - 68005297; 16721698 AB - Corticosteroids may modulate addiction. We previously described subjective, physiological, and endocrine effects of 0.5 mg/kg of intravenous methamphetamine after augmenting cortisol level with hydrocortisone or blocking cortisol response with the corticosteroid synthesis inhibitor metyrapone in a double-blind, balanced crossover study. Although the pharmacologic manipulations produced the expected hormonal changes, pleasurable subjective effects of methamphetamine were unchanged. Metyrapone was followed by frequent premature ventricular complexes (PVCs) in two subjects during methamphetamine administration. In order to better understand these results, we examined changes in two plasma catecholamine metabolites, homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), and their relationship to the previously reported hormonal changes and physiological and subjective responses. Plasma from 10 methamphetamine subjects from the earlier study was assayed for HVA and MHPG by high performance liquid chromatography. HVA levels were greater after hydrocortisone or metyrapone pretreatment compared to placebo, and MHPG levels were greater after metyrapone pretreatment. Hydrocortisone pretreatment diminished HVA and MHPG increases after methamphetamine (perhaps explaining the lack of expected increase in pleasurable effects), but metyrapone did not. HVA and MHPG concentrations were not correlated with pleasurable drug effects but were inversely related to reports of "Bad Drug Effect." Increases in MHPG and DHEA concentrations were positively correlated. Metyrapone pre-treated subjects with PVCs had lower HVA and MHPG concentrations. Raising cortisol concentration and blocking cortisol synthesis did not produce opposite effects, perhaps because of metyrapone's effect on the hypothalamic-pituitary-adrenal axis, its stress-like effects, and its effects on neurosteroids. JF - Pharmacopsychiatry AU - Harris, D S AU - Reus, V I AU - Wolkowitz, O AU - Jacob, P AU - Everhart, E T AU - Wilson, M AU - Mendelson, J E AU - Jones, R T AD - Department of Psychiatry and Tri-State Tobacco and Alcohol Research Center, University of Cincinnati and Cincinnati VA Medical Center, Cincinnati, OH 45220, USA. debra.harris4@va.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 100 EP - 108 VL - 39 IS - 3 SN - 0176-3679, 0176-3679 KW - Methoxyhydroxyphenylglycol KW - 534-82-7 KW - Dextroamphetamine KW - TZ47U051FI KW - Hydrocortisone KW - WI4X0X7BPJ KW - Homovanillic Acid KW - X77S6GMS36 KW - Metyrapone KW - ZS9KD92H6V KW - Index Medicus KW - Hypothalamo-Hypophyseal System -- drug effects KW - Drug Interactions KW - Double-Blind Method KW - Infusions, Intravenous KW - Humans KW - Methoxyhydroxyphenylglycol -- blood KW - Homovanillic Acid -- blood KW - Metyrapone -- pharmacology KW - Premedication KW - Adult KW - Cross-Over Studies KW - Pituitary-Adrenal System -- drug effects KW - Male KW - Electrocardiography -- drug effects KW - Hydrocortisone -- pharmacology KW - Reward KW - Arousal -- drug effects KW - Hydrocortisone -- antagonists & inhibitors KW - Hydrocortisone -- blood KW - Dextroamphetamine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68005297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacopsychiatry&rft.atitle=Catecholamine+response+to+methamphetamine+is+related+to+glucocorticoid+levels+but+not+to+pleasurable+subjective+response.&rft.au=Harris%2C+D+S%3BReus%2C+V+I%3BWolkowitz%2C+O%3BJacob%2C+P%3BEverhart%2C+E+T%3BWilson%2C+M%3BMendelson%2C+J+E%3BJones%2C+R+T&rft.aulast=Harris&rft.aufirst=D&rft.date=2006-05-01&rft.volume=39&rft.issue=3&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Pharmacopsychiatry&rft.issn=01763679&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-28 N1 - Date created - 2006-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The art of prescribing. Antidepressants in late-life depression: prescribing principles. AN - 67943444; 16677141 AB - Ms. Antai-Otong, I am a psychiatric nurse practitioner currently employed in a large primary care clinic. My greatest challenge with older adults suspected of being depressed is their hesitancy to admit they are depressed or unwillingness to take antidepressants. I have started some of these patients on antidepressants and had mixed results. Please provide some guidelines for treating depression in older adults with coexisting medical conditions. Depression is a common companion of chronic medical illnesses and frequently goes unrecognized and untreated, resulting in high morbidity and mortality. Depression is unrecognized and underdiagnosed in approximately 16% of older patients seen in primary care settings (Unutzer, 2002). Typically, older adults deny being depressed, minimize symptom severity, fail to recognize common subjective experiences, such as anhedonia, fatigue, and concentration difficulties associated with this disorder, and hesitate to accept their illness due to social stigma and effects of stoicism. Cultural and generational influences also impact how older adults perceive mental health services. Due to the growing number of individuals 65 and older with coexisting medical and psychiatric conditions, particularly depression, seeking health care in vast practice settings, advanced practice psychiatric nurses must collaborate with primary care providers and develop holistic care that addresses coexisting chronic medical and psychiatric conditions. JF - Perspectives in psychiatric care AU - Antai-Otong, Deborah AD - deborah.antai-otong@med.va.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 149 EP - 153 VL - 42 IS - 2 SN - 0031-5990, 0031-5990 KW - Antidepressive Agents KW - 0 KW - Nursing KW - Drug Interactions KW - Blood Chemical Analysis KW - Humans KW - Health Status KW - Aged KW - Depressive Disorder, Major -- diagnosis KW - Depressive Disorder, Major -- drug therapy KW - Drug Prescriptions -- standards KW - Depressive Disorder, Major -- chemically induced KW - Antidepressive Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67943444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+psychiatric+care&rft.atitle=The+art+of+prescribing.+Antidepressants+in+late-life+depression%3A+prescribing+principles.&rft.au=Antai-Otong%2C+Deborah&rft.aulast=Antai-Otong&rft.aufirst=Deborah&rft.date=2006-05-01&rft.volume=42&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+psychiatric+care&rft.issn=00315990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-29 N1 - Date created - 2006-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Self-efficacy, therapeutic alliance, and alcohol-use disorder treatment outcomes. AN - 67903617; 16608158 AB - High abstinence self-efficacy reliably predicts better treatment outcomes for patients with alcohol use disorders, but little is known about aspects of treatment that may be particularly beneficial for patients who enter treatment with low self-efficacy. This study examines whether the relationship between self-efficacy and treatment outcomes is influenced by the quality of the therapeutic alliance in Project MATCH (Matching Alcoholism Treatments to Client Heterogeneity), a multisite clinical trial of three treatments for alcohol use disorders. Information on 785 patients in the outpatient sample of Project MATCH was used to test for an interaction between baseline self-efficacy and therapeutic alliance in relation to 1-year alcohol use outcomes. A significant interaction was found between self-efficacy and the therapists' perception of the therapeutic alliance predicting I1year drinking outcomes. Patients with low self-efficacy who established a strong treatment alliance, as judged by the therapist, experienced I1year outcomes that were superior to those of patients with low self-efficacy with poorer treatment alliance and comparable with those of patients with high self-efficacy. Therapeutic alliance was not strongly related to the outcomes of patients with high baseline self-efficacy. In patients who are treated for alcohol-use disorders, a positive therapeutic alliance may counteract the negative impact of a low baseline self-efficacy. Potential reasons why the therapist's perception of the alliance may be particularly important for patients with low self-efficacy are discussed. JF - Journal of studies on alcohol AU - Ilgen, Mark AU - Tiet, Quyen AU - Finney, John AU - Moos, Rudolf H AD - Center for Health Care Evaluation, Department of Veterans Affairs, Veterans Affairs Palo Alto Health Care System, and Stanford California 94025, USA. Mark.Ilgen@med.va.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 465 EP - 472 VL - 67 IS - 3 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Humans KW - Adult KW - Treatment Outcome KW - Surveys and Questionnaires KW - Adolescent KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Patient Compliance -- statistics & numerical data KW - Cooperative Behavior KW - Self Efficacy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67903617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Self-efficacy%2C+therapeutic+alliance%2C+and+alcohol-use+disorder+treatment+outcomes.&rft.au=Ilgen%2C+Mark%3BTiet%2C+Quyen%3BFinney%2C+John%3BMoos%2C+Rudolf+H&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2006-05-01&rft.volume=67&rft.issue=3&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preference-weighted health status associated with substance use-disorders treatment. AN - 67902484; 16608154 AB - Cost-effectiveness analyses using preference-weighted health status as the measure of effectiveness allow for the direct comparison of cost-effectiveness ratios for physical and mental health interventions. However, these analyses are not commonly used for substance use-disorders interventions. We conducted a methodological evaluation of the relationship between preference-weighted health status and 6-month substance use-disorders treatment outcomes. The design was an observational study of clients receiving substance use-disorders treatment. Fifteen high-volume treatment centers within a regional managed behavioral health care organization participated. There were 165 subjects (117 men, 48 women) diagnosed with current Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, substance dependence in the analysis. Baseline and 6-month data included substance-use quantity, frequency, and diagnostic criteria and preference-weighted Medical Outcomes Study Short Form-36 scores based on visual analog scale (VAS) and standard gamble (SG) conversion formulas. Controlling for sociodemographic variables, VAS change for early remission at 6 months was 0.107 (p = .0002) (reference category continued dependence). SG change for early remission at 6 months was 0.041 (p < .0004). Using heavy drinkers as the reference category, VAS preference-weighted change was 0.062 (p = .10) for abstinent and 0.112 (p = .01) for moderate drinkers. SG preference-weighted change was 0.027 (p = .08) for abstinent and 0.046 (p = .01) for moderate drinkers. These findings support the construct validity of preference-weighted health status in substance use-disorders treatment. Direct comparisons of the cost-effectiveness of substance use-disorders treatment with other mental or physical health interventions are critical during times of limited health care resources. JF - Journal of studies on alcohol AU - Pyne, Jeffrey M AU - Booth, Brenda M AU - Farahati, Farah AU - Tripathi, Shanti AU - Smith, G Richard AU - Marques, Paul R AD - Veterans Administration Health Services Research and Development Center for Mental Healthcare & Outcomes Research, Central Arkansas Veterans Healthcare System, and the University of Arkansas for Medical Sciences, Little Rock, Arkansas. jmpyne@uams.edu Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 436 EP - 444 VL - 67 IS - 3 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Humans KW - Mental Health Services -- utilization KW - Mental Health Services -- economics KW - Socioeconomic Factors KW - Demography KW - Health Status Indicators KW - Health Maintenance Organizations KW - Behavior Therapy KW - Cost-Benefit Analysis KW - Adult KW - Treatment Outcome KW - Temperance KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Male KW - Remission Induction KW - Substance-Related Disorders -- therapy KW - Choice Behavior KW - Health Status KW - Substance-Related Disorders -- economics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67902484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Preference-weighted+health+status+associated+with+substance+use-disorders+treatment.&rft.au=Pyne%2C+Jeffrey+M%3BBooth%2C+Brenda+M%3BFarahati%2C+Farah%3BTripathi%2C+Shanti%3BSmith%2C+G+Richard%3BMarques%2C+Paul+R&rft.aulast=Pyne&rft.aufirst=Jeffrey&rft.date=2006-05-01&rft.volume=67&rft.issue=3&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Safety and tolerability of mood-stabilising anticonvulsants in the elderly. AN - 67858649; 16610969 AB - The authors review current research on the safety and tolerability of anticonvulsant medications used for individuals over the age of 60 years with affective disorders, agitation and other psychiatric disorders. Three anticonvulsants currently approved in the US for treatment of bipolar affective disorder are reviewed: valproate, lamotrigine and extended-release carbamazepine. The authors discuss the pharmacokinetics, pharmacodynamics, drug-drug interactions and the impact of ageing for each drug. There are few studies of anticonvulsant medications in elderly patients with bipolar disorder or other psychiatric conditions. Therefore, the authors summarise adverse events of greatest prevalence and/or greatest severity based on data derived predominately from studies of geriatric patients with epilepsy and/or other non-psychiatric indications. Guidelines are offered for the safe use of these medications in the elderly, based on research literature. JF - Expert opinion on drug safety AU - Fenn, Howard H AU - Sommer, Barbara R AU - Ketter, Terence A AU - Alldredge, Brian AD - Menlo Park Division, Palo Alto Veterans Affairs Healthcare System, Menlo Park, California 94025, USA. howard.fenn@med.va.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 401 EP - 416 VL - 5 IS - 3 KW - Anticonvulsants KW - 0 KW - Antimanic Agents KW - Triazines KW - Carbamazepine KW - 33CM23913M KW - Valproic Acid KW - 614OI1Z5WI KW - lamotrigine KW - U3H27498KS KW - Index Medicus KW - Drug Interactions KW - Carbamazepine -- adverse effects KW - Carbamazepine -- pharmacokinetics KW - Aged, 80 and over KW - Humans KW - Aged KW - Valproic Acid -- adverse effects KW - Triazines -- pharmacokinetics KW - Middle Aged KW - Carbamazepine -- therapeutic use KW - Valproic Acid -- therapeutic use KW - Triazines -- adverse effects KW - Triazines -- therapeutic use KW - Valproic Acid -- pharmacokinetics KW - Antimanic Agents -- pharmacokinetics KW - Anticonvulsants -- pharmacokinetics KW - Bipolar Disorder -- drug therapy KW - Antimanic Agents -- adverse effects KW - Anticonvulsants -- adverse effects KW - Antimanic Agents -- therapeutic use KW - Anticonvulsants -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67858649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+safety&rft.atitle=Safety+and+tolerability+of+mood-stabilising+anticonvulsants+in+the+elderly.&rft.au=Fenn%2C+Howard+H%3BSommer%2C+Barbara+R%3BKetter%2C+Terence+A%3BAlldredge%2C+Brian&rft.aulast=Fenn&rft.aufirst=Howard&rft.date=2006-05-01&rft.volume=5&rft.issue=3&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+safety&rft.issn=1744-764X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-04 N1 - Date created - 2006-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diabetic nephropathy: leveraging mouse genetics. AN - 67855067; 16609287 AB - Advances in mouse genetics have made this species particularly useful as a model for human disease. This review will summarize recent advances regarding the pathogenesis of diabetic nephropathy discovered in mice. Diabetic nephropathy has been characterized in novel genetic models of murine diabetes including the Akita, Ove26, and ICER-Igamma mice. Mutagenesis resources targeting every gene of the genome and the importance of inbred genetic background are discussed. Through the use of these resources mouse models should provide new insight into the pathogenesis of diabetic nephropathy, and complement human studies and validate the identity of candidate genes contributing to diabetic nephropathy. JF - Current opinion in nephrology and hypertension AU - Breyer, Matthew D AU - Qi, Zhonghua AU - Tchekneva, Elena AD - Division of Nephrology, Department of Medicine and Department of Molecular Physiology and Biophysics, Vanderbilt University, and Veterans Administration Medical Center, Nashville, Tennessee 3723, USA. matthew.breyer@vanderbilt.edu Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 227 EP - 232 VL - 15 IS - 3 SN - 1062-4821, 1062-4821 KW - Index Medicus KW - Animals KW - Mice KW - Mutagenesis KW - Diabetic Nephropathies -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67855067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+nephrology+and+hypertension&rft.atitle=Diabetic+nephropathy%3A+leveraging+mouse+genetics.&rft.au=Breyer%2C+Matthew+D%3BQi%2C+Zhonghua%3BTchekneva%2C+Elena&rft.aulast=Breyer&rft.aufirst=Matthew&rft.date=2006-05-01&rft.volume=15&rft.issue=3&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+nephrology+and+hypertension&rft.issn=10624821&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-21 N1 - Date created - 2006-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Electrophysiological Analysis of Error Monitoring in Schizophrenia AN - 57217127; 200613150 AB - In this study, the authors sought to determine whether abnormalities exhibited by schizophrenia patients in event-related potentials associated with self-monitoring -- the error-related negativity (ERN) & the correct response negativity (CRN) -- persist under conditions that maximize ERN amplitude & to examine relationships between the ERN & behavior in schizophrenia. Participants performed a flanker task under 2 contingencies: one encouraging accuracy & another emphasizing speed. Compared with healthy participants, in schizophrenia patients the ERN was reduced in the accuracy condition, & the CRN was enhanced in the speed condition. The amplitude of a later ERP component, the error positivity, did not differ between groups in either task condition. Reduced self-correction & increased accuracy following errors were associated with larger ERNs in both groups. Thus, ERN generation appears to be abnormal in schizophrenia patients even under conditions demonstrated to maximize ERN amplitude; however, functional characteristics of the ERN appear to be intact. 2 Tables, 4 Figures, 65 References. [Copyright 2006 American Psychological Association.] JF - Journal of Abnormal Child Psychology AU - Morris, Sarah E AU - Yee, Cindy M AU - Nuechterlein, Keith H AD - Veterans Administration Capitol Health Care Network, Mental Illness Research/Education/Clinical Center, Balt sarah.morris2@med.va.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 239 EP - 250 PB - American Psychological Association, Washington DC VL - 115 IS - 2 SN - 0091-0627, 0091-0627 KW - self-monitoring, schizophrenia, error-related negativity KW - Schizophrenia KW - Selfmonitoring KW - Electrophysiology KW - Errors KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57217127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Child+Psychology&rft.atitle=Electrophysiological+Analysis+of+Error+Monitoring+in+Schizophrenia&rft.au=Morris%2C+Sarah+E%3BYee%2C+Cindy+M%3BNuechterlein%2C+Keith+H&rft.aulast=Morris&rft.aufirst=Sarah&rft.date=2006-05-01&rft.volume=115&rft.issue=2&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Child+Psychology&rft.issn=00910627&rft_id=info:doi/10.1037%2F0021-843X.115.2.239 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - JABCAA N1 - SubjectsTermNotLitGenreText - Schizophrenia; Electrophysiology; Errors; Selfmonitoring DO - http://dx.doi.org/10.1037/0021-843X.115.2.239 ER - TY - JOUR T1 - Housing Outcomes for Hospitalized Homeless Veterans AN - 57044994; 200614526 AB - This study examines housing status at the time of hospital discharge in a national sample of 3,502 veterans who were homeless at admission to a Veterans Health Administration (VHA) medical center. A supplemental survey on homelessness was added to the annual VHA inpatient census over a 4-year period (1995 through 1998). Data from this survey were used to identify homeless veterans hospitalized on the final day of the fiscal year & to document their housing status at discharge. A signal detection technique, Receiver Operating Characteristic analysis, was used to identify predictors of housing status at discharge. At discharge, only 13% of the veterans in our analytic sample were literally homeless, 40% were doubled up, & 33% were transferred to another an institution; only 13% were living independently. Housing status at admission (specifically, staying with friends or family temporarily rather than literally homeless), treatment in a psychiatric or substance abuse program rather than a medical program, & a greater income level or access to VHA benefits were found to be associated with better housing outcomes. As one might expect, homelessness was infrequently resolved during an acute inpatient hospitalization, but few veterans returned to literal homelessness at the time of discharge. 1 Table, 3 Figures. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Greenberg, Greg A AU - Hoblyn, Jennifer AU - Seibyl, Catherine AU - Rosenheck, Robert A AD - Northeast Program Evaluation Center, Veterans Administration Medical Center, West Haven, CT greg.greenberg@yale.edu Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 425 EP - 440 PB - John Hopkins University Press, Baltimore MD VL - 17 IS - 2 SN - 1049-2089, 1049-2089 KW - Homelessness, health services, hospitalization, housing, veterans KW - Discharge KW - Veterans KW - Housing KW - Hospitalization KW - Homelessness KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57044994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Housing+Outcomes+for+Hospitalized+Homeless+Veterans&rft.au=Greenberg%2C+Greg+A%3BHoblyn%2C+Jennifer%3BSeibyl%2C+Catherine%3BRosenheck%2C+Robert+A&rft.aulast=Greenberg&rft.aufirst=Greg&rft.date=2006-05-01&rft.volume=17&rft.issue=2&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-10-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Veterans; Homelessness; Hospitalization; Housing; Discharge ER - TY - JOUR T1 - Assessing the Structure of Smoking Cessation Care in the Veterans Health Administration AN - 57037943; 200615511 AB - Purpose. National smoking cessation practice guidelines offer recommendations regarding the processes and structure of care. Facilities routinely measure the processes of care but not the structure of care. This pilot study assessed the structure of smoking cessation care at Veterans Health Administration facilities. Methods. Key informants at 18 sites completed a brief checklist survey adapted from national smoking cessation guidelines. Responses were compared with detailed site surveys. Results. Guideline adherence was seen in identifying smokers and treating inpatient smokers. Areas of low adherence include offering incentives and defining staff responsibilities. The checklist survey showed poor correspondence with the detailed survey, with low agreement on systematic screening (kappa = .21) and higher agreement on primary care prescribing authority (kappa = .53). Discussion. This pilot survey provides a potential rapid method for assessing adherence to systems recommendations from the national smoking cessation guidelines. The relatively low agreement with a more detailed survey suggests that the two surveys may have been measuring different aspects of smoking cessation care. 2 Tables, 8 References. Adapted from the source document. JF - American Journal of Health Promotion AU - Sherman, Scott E AU - Yano, Elizabeth M AU - York, Laura S AU - Lanto, Andy B AU - Chernof, Bruce A AU - Mittman, Brian S AD - Veterans Administration Health Services Research & Development Center Excellence Study Healthcare Provider B Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 313 EP - 318 PB - AJHP Inc, West Bloomfield MI VL - 20 IS - 5 SN - 0890-1171, 0890-1171 KW - Smoking Cessation, Health Care Quality Assessment, Practice Guidelines, Organizational Structure, Survey Methods, Questionnaires, Structure of Care, Quality Measurement, Veterans, Guidelines, Prevention Research KW - Veterans KW - Smoking KW - Health care KW - Cessation KW - Organizational structure KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57037943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion&rft.atitle=Assessing+the+Structure+of+Smoking+Cessation+Care+in+the+Veterans+Health+Administration&rft.au=Sherman%2C+Scott+E%3BYano%2C+Elizabeth+M%3BYork%2C+Laura+S%3BLanto%2C+Andy+B%3BChernof%2C+Bruce+A%3BMittman%2C+Brian+S&rft.aulast=Sherman&rft.aufirst=Scott&rft.date=2006-05-01&rft.volume=20&rft.issue=5&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion&rft.issn=08901171&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-10-02 N1 - Last updated - 2016-09-27 N1 - CODEN - AJHPED N1 - SubjectsTermNotLitGenreText - Smoking; Cessation; Veterans; Health care; Organizational structure ER - TY - JOUR T1 - Invasive nontypeable Haemophilus influenzae infection in an adult with laryngeal cancer AN - 20861028; 6836732 AB - We describe the first case of a man diagnosed with laryngeal cancer presenting with nontypeable Haemophilus influenzae bacteremia and dissemination to a gouty joint and review the pertinent literature. JF - Diagnostic Microbiology and Infectious Disease AU - Turner, Todd D AU - Zelazny, Adrian M AU - Kan, Virginia L AD - Infectious Diseases Section, VA Medical Center, Washington, DC 20422, USA, virginia.kan@med.va.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 85 EP - 87 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 55 IS - 1 SN - 0732-8893, 0732-8893 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Haemophilus influenzae KW - Nontypeable strain KW - Bacteremia KW - Septic arthritis KW - Laryngeal cancer KW - Invasiveness KW - Reviews KW - Infection KW - Joints KW - J 02855:Human Bacteriology: Others KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20861028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+Microbiology+and+Infectious+Disease&rft.atitle=Invasive+nontypeable+Haemophilus+influenzae+infection+in+an+adult+with+laryngeal+cancer&rft.au=Turner%2C+Todd+D%3BZelazny%2C+Adrian+M%3BKan%2C+Virginia+L&rft.aulast=Turner&rft.aufirst=Todd&rft.date=2006-05-01&rft.volume=55&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Diagnostic+Microbiology+and+Infectious+Disease&rft.issn=07328893&rft_id=info:doi/10.1016%2Fj.diagmicrobio.2005.11.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Invasiveness; Laryngeal cancer; Reviews; Bacteremia; Infection; Joints; Haemophilus influenzae DO - http://dx.doi.org/10.1016/j.diagmicrobio.2005.11.006 ER - TY - JOUR T1 - Risk of Selected Cardiovascular Diseases and Posttraumatic Stress Disorder among Former World War II Prisoners of War AN - 19520234; 7232178 AB - PURPOSE: American World War II (WWII) prisoners of war (POWs) suffered both mental and physical deprivation while interned. The long-term health consequences of the internment were studied for an increased risk of cardiovascular diseases and posttraumatic stress disorder (PTSD). METHODS: This study evaluated healthcare utilization data for 10 years (1991-2000) from Veterans Affairs (VA) and non-VA healthcare providers for 19,442 former WWII POWs and 9728 non-POW controls. The risk of diseases was approximated by odds ratios adjusted for race and age. RESULTS: Collectively, former POWs had statistically significant increased risk of PTSD, and those POWs with PTSD also had statistically significant increased risks of cardiovascular diseases including hypertension and chronic ischemic heart disease when compared to both non-POWs and POWs without PTSD. CONCLUSIONS: Among former WWII POWs, risk of cardiovascular disease is related to having PTSD. JF - Annals of Epidemiology AU - Kang, H K AU - Bullman, T A AU - Taylor, J W AD - Department Of Veterans Affairs (135), Environmental Epidemiology Service, 810 Vermont Ave Washington, DC 20420, USA, han.kang@hq.med.va.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 381 EP - 386 VL - 16 IS - 5 SN - 1047-2797, 1047-2797 KW - Risk Abstracts KW - prisons KW - posttraumatic stress disorder KW - Health care KW - Psychology KW - hypertension KW - Cardiovascular diseases KW - war KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19520234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Risk+of+Selected+Cardiovascular+Diseases+and+Posttraumatic+Stress+Disorder+among+Former+World+War+II+Prisoners+of+War&rft.au=Kang%2C+H+K%3BBullman%2C+T+A%3BTaylor%2C+J+W&rft.aulast=Kang&rft.aufirst=H&rft.date=2006-05-01&rft.volume=16&rft.issue=5&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2005.03.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - prisons; Health care; posttraumatic stress disorder; Psychology; hypertension; Cardiovascular diseases; war DO - http://dx.doi.org/10.1016/j.annepidem.2005.03.004 ER - TY - JOUR T1 - A comparison of neurocognitive function in nonsmoking and chronically smoking short-term abstinent alcoholics AN - 19311238; 7040750 AB - Approximately 70-90% of individuals in North America seeking treatment for alcoholism are chronic smokers. A growing body of evidence suggests chronic cigarette smoking alone adversely affects neurocognition in adults. However, few studies on the neurocognitive function of short-term abstinent alcoholics have specifically considered the potential effects of chronic cigarette smoking. In this study, 20 nonsmoking recovering alcoholics (nsRA) and 22 actively smoking recovering alcoholics (sRA) participants, matched on age and education, were contrasted on a comprehensive neurocognitive battery after 34 +/- 9 days of abstinence. nsRA were superior to sRA on measures of auditory-verbal learning and memory, processing speed, cognitive efficiency, and static postural stability. These group differences were not a function of group disparities in age, education, estimated premorbid verbal intelligence, lifetime alcohol consumption, or other measured comorbid psychiatric or medical factors. In sRA, longer smoking duration was negatively correlated with executive skills, visuospatial learning, general cognitive efficiency, and static postural stability. These results indicate that greater consideration of the potential neurobiological effects of current chronic smoking on neurocognitive functioning is warranted in studies of alcoholism and other conditions where smoking is a common comorbid factor. JF - Alcohol AU - Durazzo, Timothy C AU - Rothlind, Johannes C AU - Gazdzinski, Stefan AU - Banys, Peter AU - Meyerhoff, Dieter J AD - San Francisco Veterans Administration Medical Center, Center for Imaging of Neurodegenerative Disease, San Francisco, CA, USA, timothy.durazzo@ucsf.edu Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 1 EP - 11 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 39 IS - 1 SN - 0741-8329, 0741-8329 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Alcoholism KW - Alcohol dependence KW - Chronic cigarette smoking KW - Neurocognition KW - Abstinence KW - Learning KW - Drug abuse KW - Alcoholics KW - Cognition KW - Intelligence KW - Memory KW - Cognitive ability KW - Information processing KW - Cigarette smoking KW - Posture KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19311238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol&rft.atitle=A+comparison+of+neurocognitive+function+in+nonsmoking+and+chronically+smoking+short-term+abstinent+alcoholics&rft.au=Durazzo%2C+Timothy+C%3BRothlind%2C+Johannes+C%3BGazdzinski%2C+Stefan%3BBanys%2C+Peter%3BMeyerhoff%2C+Dieter+J&rft.aulast=Durazzo&rft.aufirst=Timothy&rft.date=2006-05-01&rft.volume=39&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/10.1016%2Fj.alcohol.2006.06.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Intelligence; Memory; Learning; Cognitive ability; Information processing; Alcoholism; Cigarette smoking; Drug abuse; Posture; Cognition; Alcoholics; Ethanol DO - http://dx.doi.org/10.1016/j.alcohol.2006.06.006 ER - TY - JOUR T1 - Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase-extracellular signal-regulated kinase and Janus kinase-signal transducer and activator of transcription signaling cascades on neuronal survival AN - 19277273; 6785631 AB - Rho family GTPases promote the survival of certain neuronal populations. However, pro-survival and pro-death signaling pathways regulated downstream of Rho GTPases are largely unknown. Cerebellar granule neurons (CGNs) exposed to Clostridium difficile toxin B (ToxB), a monoglucosyltransferase that specifically inhibits Rho GTPases, die by a mitochondrial apoptotic cascade. Using a high-throughput immunoblotting screen (BD Powerblot), we found that ToxB markedly reduced the expression of Rac1 and c-Raf, upstream components of a Rac-dependent mitogen-activated protein (MAP) kinase pathway. Moreover, ToxB rapidly suppressed a p21-activated kinase-MAP kinase kinase (MEK)-extracellular signal-regulated kinase (ERK)1-2 signaling cascade that normally promotes degradation of the Bcl-2 homology-3 (BH3)-only protein Bim, a key initiator of mitochondrial apoptosis. In contrast to c-Raf down-regulation, ToxB enhanced expression of the transcription factor, signal transducer and activator of transcription-1 (STAT1). Both STAT1 up-regulation and apoptosis induced by ToxB were prevented by a pan-inhibitor of Janus kinases (JAKs), indicating that JAK-STAT signaling was pro-apoptotic in CGNs. Most significantly, direct inhibition of MEK was sufficient to trigger JAK-dependent STAT1 expression, suggesting that cross-talk between MEK-ERK and JAK-STAT pathways plays a key role in regulating neuronal survival. Finally, ERK dephosphorylation and STAT1 up-regulation induced by ToxB were mimicked by a dominant-negative (N17) mutant of Rac1. These data suggest that the MEK-ERK cascade functions downstream of Rac GTPase to actively repress pro-apoptotic JAK-STAT signaling in healthy CGNs. JF - Journal of Neurochemistry AU - Loucks, FAlexandra AU - Le, Shoshona S AU - Zimmermann, Angela K AU - Ryan, Kristen R AU - Barth, Holger AU - Aktories, Klaus AU - Linseman, Daniel A AD - Research Service, Veterans Affairs Medical Center, Denver, Colorado, USA Neuroscience Program, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA, Dan.Linseman@med.va.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 957 EP - 967 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 97 IS - 4 SN - 0022-3042, 0022-3042 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Cell survival KW - Immunoblotting KW - MAP kinase KW - Apoptosis KW - Data processing KW - Rac1 protein KW - Dephosphorylation KW - Cerebellum KW - Mitochondria KW - BIM protein KW - Janus kinase KW - Granule cells KW - Extracellular signal-regulated kinase KW - Stat1 protein KW - Transcription factors KW - Toxin B KW - Clostridium difficile KW - Bcl-2 protein KW - Signal transduction KW - Guanosinetriphosphatase KW - J 02310:Genetics & Taxonomy KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19277273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Rho+family+GTPase+inhibition+reveals+opposing+effects+of+mitogen-activated+protein+kinase+kinase-extracellular+signal-regulated+kinase+and+Janus+kinase-signal+transducer+and+activator+of+transcription+signaling+cascades+on+neuronal+survival&rft.au=Loucks%2C+FAlexandra%3BLe%2C+Shoshona+S%3BZimmermann%2C+Angela+K%3BRyan%2C+Kristen+R%3BBarth%2C+Holger%3BAktories%2C+Klaus%3BLinseman%2C+Daniel+A&rft.aulast=Loucks&rft.aufirst=FAlexandra&rft.date=2006-05-01&rft.volume=97&rft.issue=4&rft.spage=957&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/10.1111%2Fj.1471-4159.2006.03802.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - SuppNotes - Figures, 7; references, 49. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Immunoblotting; MAP kinase; Data processing; Apoptosis; Rac1 protein; Dephosphorylation; Cerebellum; Mitochondria; BIM protein; Janus kinase; Granule cells; Extracellular signal-regulated kinase; Stat1 protein; Transcription factors; Toxin B; Bcl-2 protein; Guanosinetriphosphatase; Signal transduction; Clostridium difficile DO - http://dx.doi.org/10.1111/j.1471-4159.2006.03802.x ER - TY - JOUR T1 - Between-Meal Risedronate Does Not Alter Bone Turnover in Nursing Home Residents AN - 19277199; 6785561 AB - OBJECTIVES: To assess the effect of between-meal weekly risedronate and daily calcium 630 mg and vitamin D 400 IU on bone turnover markers. DESIGN: Randomized,double-blind,placebo-controlled trial. SETTING: Skilled nursing home (NH). PARTICIPANTS: Sixty skilled-NH residents (46 men, 14 women), mean age plus or minus standard deviation of 76 plus or minus 6, were randomized to receive risedronate 30 mg (n=31) or matching placebo (n=29) once weekly for 12 weeks. All received 315 mg calcium with 200 IU vitamin D twice daily. MEASUREMENTS: Bone-specific alkaline phosphatase (BSAP), N-telopeptide of type 1 collagen (NTx), 25-hydroxyvitamin D (25OHD), and parathyroid hormone were measured at baseline and 6 and 12 weeks. RESULTS: Risedronate reduced BSAP significantly more than placebo (P<.05) at 6 weeks but not at 12 weeks; no treatment effect on serum NTx was observed. Defining hypovitaminosis D as a serum 25OHD concentration below 32 ng-mL, 50 of 53 (94%) study participants were low at baseline (mean 25OHD 19 ng-mL). Vitamin D levels remained insufficient in 74% of participants after 12 weeks. CONCLUSION: In this NH population, weekly risedronate administered using a between-meal dosing schedule reduced serum BSAP at 6 weeks of treatment; this effect was not observed at 12 weeks. The overall lack of change in bone turnover markers suggests that this risedronate dose and schedule would not be expected to increase bone density or reduce fracture risk in this population. Hypovitaminosis D was common and not reliably corrected by 400 IU of vitamin D daily. Despite an extremely high osteoporotic fracture risk in NH residents, additional study is required to determine under which conditions pharmacological treatment is efficacious in this population and define approaches that assure vitamin D repletion. JF - Journal of the American Geriatrics Society AU - Agrawal, Sabina AU - Krueger, Diane C AU - Engelke, Jean A AU - Nest, Lori J AU - Krause, Peggy F AU - Drinka, Paul J AU - Binkley, Neil C AD - 2870 University Avenue, Suite 100, Madison, WI 53705, sabina.agrawal@med.va.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 790 EP - 795 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 54 IS - 5 SN - 0002-8614, 0002-8614 KW - risedronate KW - Risk Abstracts KW - Bone KW - Calcium KW - Clinical trials KW - Drugs KW - Hormones KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19277199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Between-Meal+Risedronate+Does+Not+Alter+Bone+Turnover+in+Nursing+Home+Residents&rft.au=Agrawal%2C+Sabina%3BKrueger%2C+Diane+C%3BEngelke%2C+Jean+A%3BNest%2C+Lori+J%3BKrause%2C+Peggy+F%3BDrinka%2C+Paul+J%3BBinkley%2C+Neil+C&rft.aulast=Agrawal&rft.aufirst=Sabina&rft.date=2006-05-01&rft.volume=54&rft.issue=5&rft.spage=790&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2006.00696.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - SuppNotes - Figures, 3; tables, 2; references, 40. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Bone; Calcium; Hormones; Drugs; Clinical trials DO - http://dx.doi.org/10.1111/j.1532-5415.2006.00696.x ER - TY - JOUR T1 - Use of Sentinel Laboratories by Clinicians to Evaluate Potential Bioterrorism and Emerging Infections AN - 17162477; 6832247 AB - With the persistent threat of emerging infectious diseases and bioterrorism, it has become increasingly important that clinicians be able to identify the diseases that might signal the occurrence of these unusual events. Essential to a thoughtful diagnostic approach is understanding when to initiate a public health investigation and how to appropriately use commonly performed microbiology procedures in the sentinel laboratory to evaluate potential pathogens. Although diagnostic test development is evolving rapidly, recognizing many of these pathogens continues to challenge the capabilities of most sentinel laboratories. Therefore, effective, ongoing communication and education among clinicians, infection control personnel, sentinel laboratorians, public health authorities, and Laboratory Response Network reference laboratorians is the key to preparedness. JF - Clinical Infectious Diseases AU - Pien, B C AU - Saah, J R AU - Miller, SE AU - Woods, C W AD - Division of Infectious Diseases and Clinical Microbiology Laboratory, Duke University Medical Center, Durham Veterans Administration Medical Center, Durham Y1 - 2006/05/01/ PY - 2006 DA - 2006 May 01 SP - 1311 EP - 1324 VL - 42 IS - 9 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - Infectious diseases KW - bioterrorism KW - Personnel KW - Communication KW - Pathogens KW - Public health KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17162477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Use+of+Sentinel+Laboratories+by+Clinicians+to+Evaluate+Potential+Bioterrorism+and+Emerging+Infections&rft.au=Pien%2C+B+C%3BSaah%2C+J+R%3BMiller%2C+SE%3BWoods%2C+C+W&rft.aulast=Pien&rft.aufirst=B&rft.date=2006-05-01&rft.volume=42&rft.issue=9&rft.spage=1311&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Infectious diseases; Personnel; bioterrorism; Communication; Pathogens; Public health ER - TY - JOUR T1 - Cation-Induced Transcriptional Regulation of the dlt Operon of Staphylococcus aureus AN - 17148732; 6810534 AB - Lipoteichoic and wall teichoic acids (TA) are highly anionic cell envelope-associated polymers containing repeating polyglycerol/ribitol phosphate moieties. Substitution of TA with D-alanine is important for modulation of many cell envelope-dependent processes, such as activity of autolytic enzymes, binding of divalent cations, and susceptibility to innate host defenses. D-Alanylation of TA is diminished when bacteria are grown in medium containing increased NaCl concentrations, but the effects of increased salt concentration on expression of the dlt operon encoding proteins mediating D-alanylation of TA are unknown. We demonstrate that Staphylococcus aureus transcriptionally represses dlt expression in response to high concentrations of Na super(+) and moderate concentrations of Mg super(2+) and Ca super(2+) but not sucrose. Changes in dlt mRNA are induced within 15 min and sustained for several generations of growth. Mg super(2+)-induced dlt repression depends on the ArlSR two-component system. Northern blotting, reverse transcription-PCR, and SMART-RACE analyses suggest that the dlt transcript begins 250 bp upstream of the dltA start codon and includes an open reading frame immediately upstream of dltA. Chloramphenicol transacetylase transcriptional fusions indicate that a region encompassing the 171 to 325 bp upstream of dltA is required for expression and Mg super(2+)-induced repression of the dlt operon in S. aureus. JF - Journal of Bacteriology AU - Koprivnjak, Tomaz AU - Mlakar, Vid AU - Swanson, Lindsey AU - Fournier, Benedicte AU - Peschel, Andreas AU - Weiss, Jerrold P AD - Inflammation Program. Departments of Microbiology. Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa. Veterans Administration Medical Center, Iowa City, Iowa 52242. The University of Ljubljana, 1000 Ljubljana, Slovenia. Laboratoire des Listeria, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. Cellular and Molecular Microbiology, Department of Medical Microbiology and Hygiene, University Hospitals Tuebingen, 72076 Tuebingen, Germany Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 3622 EP - 3630 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 10 SN - 0021-9193, 0021-9193 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Chloramphenicol KW - transacetylase KW - Calcium KW - D-Alanine KW - Enzymes KW - Transcription KW - Salts KW - Northern blotting KW - Phosphate KW - Teichoic acids KW - Gene regulation KW - Sucrose KW - Codons KW - Staphylococcus aureus KW - Operons KW - Magnesium KW - Open reading frames KW - Sodium chloride KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17148732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Cation-Induced+Transcriptional+Regulation+of+the+dlt+Operon+of+Staphylococcus+aureus&rft.au=Koprivnjak%2C+Tomaz%3BMlakar%2C+Vid%3BSwanson%2C+Lindsey%3BFournier%2C+Benedicte%3BPeschel%2C+Andreas%3BWeiss%2C+Jerrold+P&rft.aulast=Koprivnjak&rft.aufirst=Tomaz&rft.date=2006-05-01&rft.volume=188&rft.issue=10&rft.spage=3622&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - transacetylase; Chloramphenicol; Calcium; D-Alanine; Transcription; Enzymes; Northern blotting; Salts; Phosphate; Sucrose; Gene regulation; Teichoic acids; Codons; Magnesium; Operons; Sodium chloride; Open reading frames; Staphylococcus aureus ER - TY - JOUR T1 - Ocular toxicity from pesticide exposure: A recent review AN - 1034820117; 17059590 AB - Toxic effects on eyes result from exposure to pesticides via inhalation, ingestion, dermal contact and ocular exposure. Exposure of unprotected eyes to pesticides results in the absorption in ocular tissue and potential ocular toxicity. Recent literature on the risks of ocular toxicity from pesticide exposure is limited. Ocular toxicity from pesticide exposure, including the dose-response relationship, has been studied in different animal species. Cholinesterase enzymes have been detected in animal ocular tissue, with evidence of organophosphate-induced inhibition. Pathological effects of pesticides have been observed in conjunctiva, cornea, lens, retina and the optic nerve. Pesticide exposure has been associated with retinopathy in agricultural workers and wives of farmers who used pesticides. Saku disease, an optico-autonomic peripheral neuropathy, has been described in Japan in people living in an area where organophosphates were used. Pesticide exposure is also associated with abnormal ocular movements. Progressive toxic ocular effects leading to defective vision are a serious health concern. Agricultural workers are at high risk of exposure to pesticides and associated ocular toxicity. Primary prevention is the appropriate method of protecting eyes from pesticide-related damage. This includes improved eye safety and care in workplaces, and effective pesticide regulation for maintenance of public eye health. JF - Environmental Health and Preventive Medicine AU - Jaga, Kushik AU - Dharmani, Chandrabhan AD - Department of Psychiatry, Mount Sinai School of Medicine, 51 Eiler Lane, 10533, Irvington, New York, USA, Kushik.laga@med.va.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 102 EP - 107 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 11 IS - 3 SN - 1342-078X, 1342-078X KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Agriculture KW - Inhalation KW - INW, Japan KW - Eye KW - Organophosphates KW - Eye lens KW - Conjunctiva KW - Cholinesterase KW - Optic nerve KW - Cornea KW - Vision KW - Retinopathy KW - Dose-response effects KW - Risk factors KW - Absorption KW - Occupational exposure KW - Enzymes KW - organophosphates KW - Toxicity KW - Maintenance KW - Peripheral neuropathy KW - Reviews KW - Pesticides KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034820117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+and+Preventive+Medicine&rft.atitle=Ocular+toxicity+from+pesticide+exposure%3A+A+recent+review&rft.au=Jaga%2C+Kushik%3BDharmani%2C+Chandrabhan&rft.aulast=Jaga&rft.aufirst=Kushik&rft.date=2006-05-01&rft.volume=11&rft.issue=3&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+and+Preventive+Medicine&rft.issn=1342078X&rft_id=info:doi/10.1265%2Fehpm.11.102 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Inhalation; Agriculture; Eye; Eye lens; Enzymes; Conjunctiva; Toxicity; organophosphates; Cholinesterase; Optic nerve; Cornea; Vision; Risk factors; Dose-response effects; Retinopathy; Reviews; Peripheral neuropathy; Pesticides; Occupational exposure; Organophosphates; Absorption; Maintenance; INW, Japan DO - http://dx.doi.org/10.1265/ehpm.11.102 ER - TY - CPAPER T1 - Effect of Optic Nerve Compression on the Amplitude and Phase of the Pattern Electroretinogram (PERG) and Retinal Nerve Fiber Layer Thickness (RNFL) Determined by Optical Coherence Tomography (OCT) T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 40027845; 4198184 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Kardon, R H AU - Anderson, S AU - Spanheimer, P Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Fibers KW - Optic nerve KW - Compression KW - Tomography KW - Electroretinograms KW - Nerves UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40027845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Effect+of+Optic+Nerve+Compression+on+the+Amplitude+and+Phase+of+the+Pattern+Electroretinogram+%28PERG%29+and+Retinal+Nerve+Fiber+Layer+Thickness+%28RNFL%29+Determined+by+Optical+Coherence+Tomography+%28OCT%29&rft.au=Kardon%2C+R+H%3BAnderson%2C+S%3BSpanheimer%2C+P&rft.aulast=Kardon&rft.aufirst=R&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain Networks Implicated in Word Identification in Patients with AMD Shown by FMRI T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39978498; 4197166 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Szlyk, J P AU - Little, D M AU - Modi, D AU - Thulborn, K R Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Brain KW - Functional magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39978498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Brain+Networks+Implicated+in+Word+Identification+in+Patients+with+AMD+Shown+by+FMRI&rft.au=Szlyk%2C+J+P%3BLittle%2C+D+M%3BModi%2C+D%3BThulborn%2C+K+R&rft.aulast=Szlyk&rft.aufirst=J&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Morphology and Repeatability of Automated Perimetry using Stimulus Size V: A Comparison with Size III T2 - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AN - 39927181; 4199247 JF - 2006 Anual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2006) AU - Wall, M AU - Brito, C F AU - Woodward, K R AU - Doyle, C K Y1 - 2006/04/30/ PY - 2006 DA - 2006 Apr 30 KW - Morphology KW - Automation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39927181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.atitle=Morphology+and+Repeatability+of+Automated+Perimetry+using+Stimulus+Size+V%3A+A+Comparison+with+Size+III&rft.au=Wall%2C+M%3BBrito%2C+C+F%3BWoodward%2C+K+R%3BDoyle%2C+C+K&rft.aulast=Wall&rft.aufirst=M&rft.date=2006-04-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Anual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?PageID=SearchA dvanced&MKey=%7BE6454D7C%2D010E%2D4091%2DAF0D%2D55A9210BEC13%7D&AKey ={01DBD563-E053-4A16-A83F-48E737512973} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Toxicological assessments of Gulf War veterans. AN - 67960729; 16687269 AB - Concerns about unexplained illnesses among veterans of the 1991 Gulf War appeared soon after that conflict ended. Many environmental causes have been suggested, including possible exposure to depleted uranium munitions, vaccines and other drugs used to protect troops, deliberate or accidental exposure to chemical warfare agents and pesticides and smoke from oil-well fires. To help resolve these issues, US and UK governments have sought independent expert scientific advice from prestigious, independent scientific and public health experts, including the US National Academies of Science and the UK Royal Society and Medical Research Council. Their authoritative and independent scientific and medical reviews shed light on a wide range of Gulf War environmental hazards. However, they have added little to our understanding of Gulf War veterans' illnesses, because identified health effects have been previously well characterized, primarily in the occupational health literature. This effort has not identified any new health effects or unique syndromes associated with the evaluated environmental hazards. Nor do their findings provide an explanation for significant amounts of illnesses among veterans of the 1991 Gulf War. Nevertheless, these independent and highly credible scientific reviews have proven to be an effective means for evaluating potential health effects from deployment-related environmental hazards. JF - Philosophical transactions of the Royal Society of London. Series B, Biological sciences AU - Brown, Mark AD - US Department of Veterans Affairs Office of Public Health and Environmental Hazards, Washington, DC 20420, USA. mbrown1@va.gov Y1 - 2006/04/29/ PY - 2006 DA - 2006 Apr 29 SP - 649 EP - 679 VL - 361 IS - 1468 SN - 0962-8436, 0962-8436 KW - Index Medicus KW - United States KW - National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division KW - United States Department of Veterans Affairs KW - Risk Factors KW - Humans KW - Veterans -- statistics & numerical data KW - Gulf War KW - Persian Gulf Syndrome -- epidemiology KW - Occupational Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67960729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Philosophical+transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+sciences&rft.atitle=Toxicological+assessments+of+Gulf+War+veterans.&rft.au=Brown%2C+Mark&rft.aulast=Brown&rft.aufirst=Mark&rft.date=2006-04-29&rft.volume=361&rft.issue=1468&rft.spage=649&rft.isbn=&rft.btitle=&rft.title=Philosophical+transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+sciences&rft.issn=09628436&rft_id=info:doi/ LA - 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Last updated - 2017-01-18 ER - TY - CPAPER T1 - Association of Depressive Symptoms and Cancer Screening in Postmenopausal Women: The Women's Health Initiative T2 - 29th Annual Meeting of the Society of General Internal Medicine (SGIM 2006) AN - 39976840; 4230748 JF - 29th Annual Meeting of the Society of General Internal Medicine (SGIM 2006) AU - Aggarwal, Arpita AU - Freund, Karen AU - Sato, Alicia AU - Wallace, Bob AU - Lopez, Ann M AU - Ockene, Judith K AU - Adams-Campbell, Lucille L AU - Lessin, Lawrence S AU - Williams, Carla AU - Bonds, Denise Y1 - 2006/04/26/ PY - 2006 DA - 2006 Apr 26 KW - Post-menopause KW - Cancer KW - Screening KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39976840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=29th+Annual+Meeting+of+the+Society+of+General+Internal+Medicine+%28SGIM+2006%29&rft.atitle=Association+of+Depressive+Symptoms+and+Cancer+Screening+in+Postmenopausal+Women%3A+The+Women%27s+Health+Initiative&rft.au=Aggarwal%2C+Arpita%3BFreund%2C+Karen%3BSato%2C+Alicia%3BWallace%2C+Bob%3BLopez%2C+Ann+M%3BOckene%2C+Judith+K%3BAdams-Campbell%2C+Lucille+L%3BLessin%2C+Lawrence+S%3BWilliams%2C+Carla%3BBonds%2C+Denise&rft.aulast=Aggarwal&rft.aufirst=Arpita&rft.date=2006-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=29th+Annual+Meeting+of+the+Society+of+General+Internal+Medicine+%28SGIM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sgim.org/am06/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Palliative Needs among Inpatient Veterans with Serious, Life-Limiting Illness T2 - 29th Annual Meeting of the Society of General Internal Medicine (SGIM 2006) AN - 39967765; 4230903 DE: JF - 29th Annual Meeting of the Society of General Internal Medicine (SGIM 2006) AU - Lorenz, Karl AU - Riopelle, Deborah AU - Steckart, M Jillisa AU - Wagner, Glenn AU - Rosenfeld, Kenneth E Y1 - 2006/04/26/ PY - 2006 DA - 2006 Apr 26 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39967765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=29th+Annual+Meeting+of+the+Society+of+General+Internal+Medicine+%28SGIM+2006%29&rft.atitle=Palliative+Needs+among+Inpatient+Veterans+with+Serious%2C+Life-Limiting+Illness&rft.au=Lorenz%2C+Karl%3BRiopelle%2C+Deborah%3BSteckart%2C+M+Jillisa%3BWagner%2C+Glenn%3BRosenfeld%2C+Kenneth+E&rft.aulast=Lorenz&rft.aufirst=Karl&rft.date=2006-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=29th+Annual+Meeting+of+the+Society+of+General+Internal+Medicine+%28SGIM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sgim.org/am06/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. AN - 85402599; pmid-16635227 AB - Antibiotic-associated diarrhea (AAD) is a common complication of most antibiotics and Clostridium difficile disease (CDD), which also is incited by antibiotics, is a leading cause of nosocomial outbreaks of diarrhea and colitis. The use of probiotics for these two related diseases remains controversial.To compare the efficacy of probiotics for the prevention of AAD and the treatment of CDD based on the published randomized, controlled clinical trials.PubMed, Medline, Google Scholar, NIH registry of clinical trials, metaRegister, and Cochrane Central Register of Controlled Trials were searched from 1977 to 2005, unrestricted by language. Secondary searches of reference lists, authors, reviews, commentaries, associated diseases, books, and meeting abstracts.Trials were included in which specific probiotics given to either prevent or treat the diseases of interest. Trials were required to be randomized, controlled, blinded efficacy trials in humans published in peer-reviewed journals. Trials that were excluded were pre-clinical, safety, Phase 1 studies in volunteers, reviews, duplicate reports, trials of unspecified probiotics, trials of prebiotics, not the disease being studied, or inconsistent outcome measures. Thirty-one of 180 screened studies (totally 3,164 subjects) met the inclusion and exclusion criteria.One reviewer identified studies and abstracted data on sample size, population characteristics, treatments, and outcomes.From 25 randomized controlled trials (RCTs), probiotics significantly reduced the relative risk of AAD (RR = 0.43, 95% CI 0.31, 0.58, p < 0.001). From six randomized trials, probiotics had significant efficacy for CDD (RR = 0.59, 95% CI 0.41, 0.85, p = 0.005).A variety of different types of probiotics show promise as effective therapies for these two diseases. Using meta-analyses, three types of probiotics (Saccharomyces boulardii, Lactobacillus rhamnosus GG, and probiotic mixtures) significantly reduced the development of antibiotic-associated diarrhea. Only S. boulardii was effective for CDD. JF - The American journal of gastroenterology AU - McFarland, Lynne V AD - Department of Health Services Research and Development, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98101, USA. Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 812 EP - 822 VL - 101 IS - 4 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - *Anti-Bacterial Agents: adverse effects KW - *Clostridium difficile KW - Diarrhea: etiology KW - Diarrhea: microbiology KW - *Diarrhea: prevention & control KW - *Enterocolitis, Pseudomembranous: therapy KW - Humans KW - Probiotics: adverse effects KW - *Probiotics: therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85402599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Meta-analysis+of+probiotics+for+the+prevention+of+antibiotic+associated+diarrhea+and+the+treatment+of+Clostridium+difficile+disease.&rft.au=McFarland%2C+Lynne+V&rft.aulast=McFarland&rft.aufirst=Lynne&rft.date=2006-04-01&rft.volume=101&rft.issue=4&rft.spage=812&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: Am J Gastroenterol. 2007 Jan;102(1):201-2[17266694]; Comment In: ACP J Club. 2006 Sep-Oct;145(2):46[16944866]; Comment In: Am J Gastroenterol. 2007 Jan;102(1):201; author reply 202-4[17278265] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Promoting repeat tobacco dependence treatment: are relapsed smokers interested? AN - 67861644; 16610925 AB - Promotion of repeat tobacco dependence treatment among relapsed smokers interested in "recycling" (repeat quit attempt) may be a promising approach to increase quit rates. To report relapsed smokers' interest in recycling and their treatment preferences. Descriptive analysis of a population of relapsed smokers who were randomized to receive a recycling intervention strategy to increase tobacco dependence treatment rates, as part of a randomized controlled trial at 5 Veterans Affairs medical centers. Individuals prescribed a tobacco dependence medication in 2002 were eligible and were identified from the Department of Veterans Affairs Pharmacy Benefits Management database. Intervention group participants (n = 951) were contacted for a standardized telephone interview approximately 6 months after the prescription fill date to assess smoking status, interest in recycling, and treatment preferences. Bivariate analyses and generalized linear mixed-model regressions were used to describe outcomes. The response rate to the intervention telephone call was 62% (586/951), at which 61% (357/586) of respondents had relapsed. Almost two thirds of relapsed smokers were interested in recycling within 30 days. Of these, 91% wanted behavioral or pharmacologic smoking cessation treatment, and 64% wanted behavioral and pharmacologic treatment. In multivariate analyses, independent predictors of interest in recycling within 30 days included black race, lower smoking level, and greater number of smoking-related medical conditions. Most smokers who attempt to quit but relapse want to quit again right away, and most are interested in receiving behavioral and pharmacologic treatment. JF - The American journal of managed care AU - Fu, Steven S AU - Partin, Melissa R AU - Snyder, Annamay AU - An, Lawrence C AU - Nelson, David B AU - Clothier, Barbara AU - Nugent, Sean AU - Willenbring, Mark L AU - Joseph, Anne M AD - Section of General Internal Medicine, Center for Chronic Disease Outcomes Research (VA Health Services Research & Development Center of Excellence), Veterans Affairs Medical Center (152/2E), Minneapolis, MN 55417, USA. steven.fu@va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 235 EP - 243 VL - 12 IS - 4 SN - 1088-0224, 1088-0224 KW - Health administration KW - United States KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Recurrence KW - Male KW - Female KW - Smoking Cessation -- psychology KW - Tobacco Use Disorder -- therapy KW - Health Promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67861644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+managed+care&rft.atitle=Promoting+repeat+tobacco+dependence+treatment%3A+are+relapsed+smokers+interested%3F&rft.au=Fu%2C+Steven+S%3BPartin%2C+Melissa+R%3BSnyder%2C+Annamay%3BAn%2C+Lawrence+C%3BNelson%2C+David+B%3BClothier%2C+Barbara%3BNugent%2C+Sean%3BWillenbring%2C+Mark+L%3BJoseph%2C+Anne+M&rft.aulast=Fu&rft.aufirst=Steven&rft.date=2006-04-01&rft.volume=12&rft.issue=4&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+managed+care&rft.issn=10880224&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-24 N1 - Date created - 2006-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hippocampal volume, PTSD, and alcoholism in combat veterans. AN - 67825056; 16585443 AB - Studies imposing rigorous control over lifetime alcohol intake have usually not found smaller hippocampal volumes in persons with posttraumatic stress disorder. Because the majority of negative studies have used adolescent samples, it has been suggested that chronicity is a necessary condition for such findings. To test the hypothesis that a smaller hippocampus in PTSD is unrelated to comorbid alcoholism or to chronicity, this study estimated hippocampal volume in a relatively large group (N=99) of combat veterans in which PTSD, lifetime alcohol abuse/dependence, and Vietnam versus Gulf War service were crossed. In subjects with histories of alcoholism, unadjusted hippocampal volume was 9% smaller in persons with PTSD than in those without PTSD. In nonalcoholic subjects, the PTSD-related difference in hippocampal volume was 3%. The failure to observe a strong association between PTSD and hippocampal volume in nonalcoholic subjects was not ascribable to younger age, reduced PTSD chronicity, or lower PTSD symptom severity. The possibility that smaller hippocampal volume is limited to groups in which PTSD is compounded by comorbid alcoholism is not necessarily incompatible with results suggesting a smaller hippocampus is predispositional to PTSD. Further examination of the role of alcoholism and other comorbid conditions in studies of brain structure and function in PTSD appears warranted. JF - The American journal of psychiatry AU - Woodward, Steven H AU - Kaloupek, Danny G AU - Streeter, Chris C AU - Kimble, Matthew O AU - Reiss, Allan L AU - Eliez, Stephan AU - Wald, Lawrence L AU - Renshaw, Perry F AU - Frederick, Blaise B AU - Lane, Barton AU - Sheikh, Javaid I AU - Stegman, Wendy K AU - Kutter, Catherine J AU - Stewart, Lorraine P AU - Prestel, Rebecca S AU - Arsenault, Ned J AD - National Center for PTSD, Clinical Laboratory and Education Division, Mail Code 334 PTSD, VA Palo Alto HCS, 3801 Miranda Ave., Palo Alto, CA 94304, USA. steve.woodward@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 674 EP - 681 VL - 163 IS - 4 SN - 0002-953X, 0002-953X KW - Abridged Index Medicus KW - Index Medicus KW - Depressive Disorder, Major -- diagnosis KW - Age Factors KW - Gulf War KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Depressive Disorder, Major -- epidemiology KW - Atrophy -- pathology KW - Comorbidity KW - Wechsler Scales KW - Psychiatric Status Rating Scales KW - Adult KW - Vietnam Conflict KW - Disease Susceptibility -- diagnosis KW - Middle Aged KW - Female KW - Male KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Veterans -- statistics & numerical data KW - Alcoholism -- pathology KW - Alcoholism -- epidemiology KW - Stress Disorders, Post-Traumatic -- pathology KW - Alcoholism -- diagnosis KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Veterans -- psychology KW - Combat Disorders -- diagnosis KW - Hippocampus -- pathology KW - Combat Disorders -- epidemiology KW - Combat Disorders -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67825056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Hippocampal+volume%2C+PTSD%2C+and+alcoholism+in+combat+veterans.&rft.au=Woodward%2C+Steven+H%3BKaloupek%2C+Danny+G%3BStreeter%2C+Chris+C%3BKimble%2C+Matthew+O%3BReiss%2C+Allan+L%3BEliez%2C+Stephan%3BWald%2C+Lawrence+L%3BRenshaw%2C+Perry+F%3BFrederick%2C+Blaise+B%3BLane%2C+Barton%3BSheikh%2C+Javaid+I%3BStegman%2C+Wendy+K%3BKutter%2C+Catherine+J%3BStewart%2C+Lorraine+P%3BPrestel%2C+Rebecca+S%3BArsenault%2C+Ned+J&rft.aulast=Woodward&rft.aufirst=Steven&rft.date=2006-04-01&rft.volume=163&rft.issue=4&rft.spage=674&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-24 N1 - Date created - 2006-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evolution of chronic dysphagia following treatment for head and neck cancer. AN - 67804080; 16314138 AB - We would like to assess the evolution of chronic dysphagia (1 year or more) following treatment for head and neck cancer. Modified barium swallow (MBS) examinations were performed in cancer-free patients who complained of dysphagia following treatment for head and neck cancer. The severity of the dysphagia was graded on a scale of 1-7. Each patient had at least 2 MBS. Severity of dysphagia was compared between the first and last MBS study to determine whether the swallowing dysfunction had returned to normal. Patients with complaint of dysphagia and normal MBS also underwent a regular barium swallow to assess the structural integrity of the pharynx and esophagus. Between 1996 and 2001, 25 patients with dysphagia underwent repeat MBS following treatment. Swallowing dysfunction did not return to normal in the majority of the patients. At a median time of 26 months following treatment (range 15-82 months), only two patient (8%) had normalization of the swallowing. The severity of dysphagia decreased in eight patients (32%), remained unchanged in 12 patients (48%), and worsened in five patients (20%). Eight patients (32%) still had aspiration problems at 12-83 months following treatment. Six patients (24%) required dilation because of pharyngeal stenosis. Three patients who required dilation had improvement of the dysphagia severity. Chronic dysphagia is a relentless process possibly due to excessive scarring. Patients with chronic dysphagia are at risk of malnutrition, and aspiration. Management of chronic dysphagia requires a team approach with nutritional support, psychological counseling, dilation, and tube feedings when indicated. JF - Oral oncology AU - Nguyen, Nam P AU - Moltz, Candace C AU - Frank, Cheryl AU - Vos, Paul AU - Smith, Herbert J AU - Karlsson, Ulf AU - Nguyen, Ly M AU - Rose, Sue AU - Dutta, Suresh AU - Sallah, Sabah AD - Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Radiation Oncology Service, VA North Texas Health Care System, 4500 S Lancaster Road, Dallas, TX 75216, USA. NamPhong.Nguyen@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 374 EP - 380 VL - 42 IS - 4 SN - 1368-8375, 1368-8375 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Combined Modality Therapy KW - Aged, 80 and over KW - Humans KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Chronic Disease KW - Postoperative Complications -- etiology KW - Male KW - Radiotherapy -- adverse effects KW - Antineoplastic Agents -- adverse effects KW - Head and Neck Neoplasms -- therapy KW - Deglutition Disorders -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67804080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+oncology&rft.atitle=Evolution+of+chronic+dysphagia+following+treatment+for+head+and+neck+cancer.&rft.au=Nguyen%2C+Nam+P%3BMoltz%2C+Candace+C%3BFrank%2C+Cheryl%3BVos%2C+Paul%3BSmith%2C+Herbert+J%3BKarlsson%2C+Ulf%3BNguyen%2C+Ly+M%3BRose%2C+Sue%3BDutta%2C+Suresh%3BSallah%2C+Sabah&rft.aulast=Nguyen&rft.aufirst=Nam&rft.date=2006-04-01&rft.volume=42&rft.issue=4&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=Oral+oncology&rft.issn=13688375&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-11 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Topographic imaging of quantitative EEG in response to smoked cocaine self-administration in humans. AN - 67762715; 16192989 AB - Quantitative electroencephalographic (qEEG) profiles were studied in cocaine-dependent patients in response to an acute, single-blind, self-administered dose of smoked cocaine base (50 mg) vs placebo. qEEG data were averaged using neurometric analytical methods and the spectral power of each primary bandwidth was computed and topographically imaged. Additional measures included cocaine-induced high, craving, and related subjective ratings, heart rate, blood pressure, and plasma cortisol and homovanillic acid levels. In all, 13 crack cocaine-dependent subjects were tested. Cocaine produced a rapid increase in subjective ratings of cocaine high and good drug effect, and a more persistent increase in cocaine craving and nervousness. Cocaine also produced a rapid rise in heart rate and a prolonged increase in plasma cortisol. Placebo, administered in the context of cocaine cues and dosing expectations, had no cocaine-like subjective or physiological effects. Cocaine produced a rapid increase in absolute theta, alpha, and beta power over the prefrontal cortex (FP1, FP2), lasting up to 25 min after dosing. The increase in theta power was correlated with good drug effect, and the increase in alpha power was correlated with nervousness. Cocaine also produced a similar increase in delta coherence over the prefrontal cortex, which was positively correlated with plasma cortisol, and negatively correlated with nervousness. Placebo resulted in an increase in alpha power over the prefrontal cortex. These data demonstrate the involvement of prefrontal cortex in the qEEG response to acute cocaine. Evidence indicates slow wave qEEG, delta and theta activity, involvement in the rewarding properties of cocaine. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Reid, Malcolm S AU - Flammino, Frank AU - Howard, Bryant AU - Nilsen, Diana AU - Prichep, Leslie S AD - Department of Psychiatry, New York University School of Medicine, New York, NY, USA. malcolm.reid@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 872 EP - 884 VL - 31 IS - 4 SN - 0893-133X, 0893-133X KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Heart Rate -- drug effects KW - Self Administration KW - Humans KW - Adult KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - Brain Mapping KW - Electroencephalography KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- physiopathology KW - Cocaine-Related Disorders -- etiology KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67762715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Topographic+imaging+of+quantitative+EEG+in+response+to+smoked+cocaine+self-administration+in+humans.&rft.au=Reid%2C+Malcolm+S%3BFlammino%2C+Frank%3BHoward%2C+Bryant%3BNilsen%2C+Diana%3BPrichep%2C+Leslie+S&rft.aulast=Reid&rft.aufirst=Malcolm&rft.date=2006-04-01&rft.volume=31&rft.issue=4&rft.spage=872&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-25 N1 - Date created - 2006-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship between patient complaints and surgical complications AN - 19554395; 8747497 AB - Background: Patient complaints are associated with increased malpractice risk but it is unclear if complaints might be associated with medical complications. The purpose of this study was to determine whether an association exists between patient complaints and surgical complications. Methods: A retrospective analysis of 16713 surgical admissions was conducted over a 54 month period at a single academic medical center. Surgical complications were identified using administrative data. The primary outcome measure was unsolicited patient complaints. Results: During the study period 0.9% of surgical admissions were associated with a patient complaint. 19% of admissions associated with a patient complaint included a postoperative complication compared with 12.5% of admissions without a patient complaint (p = 0.01). After adjusting for surgical specialty, co-morbid illnesses and length of stay, admissions with complications had an odds ratio of 1.74 (95% confidence interval 1.01 to 2.98) of being associated with a complaint compared with admissions without complications. Conclusions: Admissions with surgical complications are more likely to be associated with a complaint than surgical admissions without complications. Further research is necessary to determine if patient complaints might serve as markers for poor clinical outcomes. JF - Quality & Safety in Health Care AU - Murff, HJ AU - France, D J AU - Blackford, J AU - Grogan, EL AU - Yu, C AU - Speroff, T AU - Pichert, J W AU - Hickson, G B AD - Division of General Internal Medicine, Vanderbilt University Medical Center and Department of Veterans Affairs, TVHS, GRECC/HSR, Nashville, TN 37212-2637, USA, Harvev.Murff@med.va.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 VL - 15 IS - 2 SN - 1475-3898, 1475-3898 KW - Health & Safety Science Abstracts KW - Health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19554395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quality+%26+Safety+in+Health+Care&rft.atitle=Relationship+between+patient+complaints+and+surgical+complications&rft.au=Murff%2C+HJ%3BFrance%2C+D+J%3BBlackford%2C+J%3BGrogan%2C+EL%3BYu%2C+C%3BSperoff%2C+T%3BPichert%2C+J+W%3BHickson%2C+G+B&rft.aulast=Murff&rft.aufirst=HJ&rft.date=2006-04-01&rft.volume=15&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Quality+%26+Safety+in+Health+Care&rft.issn=14753898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Health care ER - TY - JOUR T1 - Knowledge and Risks of Human Immunodeficiency Virus Transmission among Veterans with Severe Mental Illness AN - 19524936; 8081174 AB - This study is among the first to examine knowledge about human immunodeficiency virus (HIV) and behavioral risks for HIV transmission among veterans with severe mental illness (SMI), a group at high risk for HIV infection. This study examined associations between accuracy of HIV knowledge, risk behaviors, and clinical and demographic characteristics in a sample of male veteran psychiatric inpatients diagnosed with SMI (N = 353). Results showed high rates of inaccurate HIV knowledge, with >40% of patients demonstrating some inaccuracies, particularly those related to the progression and symptoms of acquired immunodeficiency syndrome. Inaccurate HIV knowledge was associated with older age, minority status, education level, marital status, no homelessness within the previous 6 months, and no reported history of illicit intranasal drug use. There is a need for more effective HIV prevention interventions for persons with SMI. JF - Military Medicine AU - Strauss, J L AU - Bosworth, H B AU - Stechuchak, K M AU - Meador, K M AU - Butterfield, MI AD - Center for Health Services Research in Primary Care, Veterans Administration Medical Center, Durham, NC 27705, USA Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 325 EP - 330 VL - 171 IS - 4 SN - 0026-4075, 0026-4075 KW - Virology & AIDS Abstracts; Risk Abstracts KW - demography KW - Historical account KW - Age KW - Immunodeficiency KW - Drug abuse KW - Infection KW - Homelessness KW - Disease transmission KW - Demography KW - Education KW - Mental disorders KW - Human immunodeficiency virus KW - intervention KW - Risk factors KW - infection KW - prevention KW - Geriatrics KW - Military KW - mental disorders KW - Drugs KW - V 22360:AIDS and HIV KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19524936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+Medicine&rft.atitle=Knowledge+and+Risks+of+Human+Immunodeficiency+Virus+Transmission+among+Veterans+with+Severe+Mental+Illness&rft.au=Strauss%2C+J+L%3BBosworth%2C+H+B%3BStechuchak%2C+K+M%3BMeador%2C+K+M%3BButterfield%2C+MI&rft.aulast=Strauss&rft.aufirst=J&rft.date=2006-04-01&rft.volume=171&rft.issue=4&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Military+Medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Demography; Mental disorders; Risk factors; Geriatrics; Immunodeficiency; Infection; Drugs; Disease transmission; demography; Historical account; Age; Education; intervention; prevention; infection; Drug abuse; Military; mental disorders; Homelessness; Human immunodeficiency virus ER -