TY - JOUR T1 - A Randomized Controlled Trial of a Patient-Centered Approach to Improve Screening for the Metabolic Side Effects of Antipsychotic Medications AN - 1865323175 AB - Adherence to recommendations for monitoring of metabolic side effects of antipsychotic medications has been historically low. This randomized controlled trial tested whether a computerized, patient-centered intervention that educated Veterans with serious mental illness about these side effects and encouraged them to advocate for receipt of monitoring would increase rates of monitoring compared to enhanced treatment as usual. The mean proportion of days adherent to monitoring guidelines over the 1-year study was similarly high and did not differ between the intervention (range 0.81-0.98) and comparison (range 0.76-0.96) groups. Many individuals in both groups had persistent abnormal metabolic parameter values despite high rates of monitoring, contact with medical providers, and receipt of cardiometabolic medications. Participants exposed to the intervention were interested in receiving personalized information about their cardiometabolic status, demonstrating the preliminary feasibility of brief interventions for enhancing involvement of individuals with serious mental illness in health care decision making. JF - Community Mental Health Journal AU - Kreyenbuhl, Julie AU - Dixon, Lisa B AU - Brown, Clayton H AU - Medoff, Deborah R AU - Klingaman, Elizabeth A AU - Fang, Li Juan AU - Tapscott, Stephanie AU - Walsh, Mary Brighid AD - U.S. Department of Veterans Affairs Capitol Healthcare Network (VISN 5), Mental Illness Research, Education, and Clinical Center (MIRECC), Baltimore, MD, USA; Division of Psychiatric Services Research, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA ; Department of Psychiatry, Center for Practice Innovations, New York State Psychiatric Institute, Columbia University, New York, NY, USA ; U.S. Department of Veterans Affairs Capitol Healthcare Network (VISN 5), Mental Illness Research, Education, and Clinical Center (MIRECC), Baltimore, MD, USA; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA ; U.S. Department of Veterans Affairs Capitol Healthcare Network (VISN 5), Mental Illness Research, Education, and Clinical Center (MIRECC), Baltimore, MD, USA ; Division of Psychiatric Services Research, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA ; Department of Health Policy and Management, Rollins School of Public Health, Emory University, Atlanta, GA, USA ; U.S. Department of Veterans Affairs Capitol Healthcare Network (VISN 5), Mental Illness Research, Education, and Clinical Center (MIRECC), Baltimore, MD, USA; Division of Psychiatric Services Research, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA Y1 - 2017/02// PY - 2017 DA - Feb 2017 SP - 163 EP - 175 CY - New York PB - Springer Science & Business Media VL - 53 IS - 2 SN - 0010-3853 KW - Psychology KW - Antipsychotic medications KW - Metabolic side effects KW - Monitoring KW - Randomized controlled trial KW - Intervention KW - Patient centredness KW - Veterans KW - Health Problems KW - Side effects KW - Interventions KW - Medications KW - Mental health services KW - Mental illness KW - Screening KW - Mental Health KW - Health care KW - Feasibility KW - Antipsychotic drugs KW - Mentally ill people KW - Medical Decision Making KW - Decision making KW - Randomized controlled trials KW - Medicine KW - Tests KW - Individualized KW - Brief interventions KW - Mental Illness KW - Computerization KW - Decision Making KW - Health Care Services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1865323175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=A+Randomized+Controlled+Trial+of+a+Patient-Centered+Approach+to+Improve+Screening+for+the+Metabolic+Side+Effects+of+Antipsychotic+Medications&rft.au=Kreyenbuhl%2C+Julie%3BDixon%2C+Lisa+B%3BBrown%2C+Clayton+H%3BMedoff%2C+Deborah+R%3BKlingaman%2C+Elizabeth+A%3BFang%2C+Li+Juan%3BTapscott%2C+Stephanie%3BWalsh%2C+Mary+Brighid&rft.aulast=Kreyenbuhl&rft.aufirst=Julie&rft.date=2017-02-01&rft.volume=53&rft.issue=2&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-016-0007-5 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); Social Services Abstracts N1 - Copyright - Community Mental Health Journal is a copyright of Springer, 2017. N1 - Last updated - 2017-02-06 DO - http://dx.doi.org/10.1007/s10597-016-0007-5 ER - TY - JOUR T1 - The safety and efficacy of Diphoterine for ocular and cutaneous burns in humans. AN - 1826739956; 27486965 AB - Diphoterine, developed by the French company Prevor, is a polyvalent, chelating, amphoteric and slightly hypertonic solution used in the management of chemical cutaneous and ocular burns. While used extensively in Europe and Canada, it is has not been approved by the United States Occupational Safety and Health Administration (OSHA) as an alternative to the water-rinse method due to a lack of evidence of its safety and efficacy on human subjects. An unbiased and extensive systematic review was undertaken in order to better understand Diphoterine's safety and efficaciousness on humans. Review the safety and efficacy of Diphoterine for treating chemical burns of the skin and eyes in humans. Data sources: Information sources included Pubmed, the National Library of Medicine's Medline Database and the "Publications" sections of the Prevor website. Search terms included Diphoterine, chemical burn, ocular burn and cutaneous burn. Any study type published through a peer-reviewed journal up to May 2016 was considered eligible. Published data must have included Diphoterine in the treatment of chemical burns on the skin or eyes as well as meet other specified criteria. Acceptable studies had to use either a quantitative (e.g. number of work days lost) or qualitative (e.g. level of erythema) approach when measuring cutaneous or ocular lesion outcomes. Independent assessment of article inclusion by two authors using predefined criteria. Diphoterine is safe and highly effective in improving healing time, healing sequelae and pain management of chemical burns on the skin and eyes of humans. Outcomes are significantly improved when compared to water or a physiologic solution equivalent. We recommend that this product be readily available to emergency responders and companies that expose their employees to hazardous chemical substances in order to improve healing sequelae, pain management and lost work days from these types of burns. JF - Cutaneous and ocular toxicology AU - Lynn, Darren D AU - Zukin, Leonid M AU - Dellavalle, Robert AD - a Department of Dermatology and. ; b Department of Opthamology , Denver School of Medicine, University of Colorado , Aurora , CO , USA , and. ; c U.S. Department of Veterans Affairs, Eastern Colorado Health Care System, Dermatology Service , Denver , CO , USA. Y1 - 2017/01/17/ PY - 2017 DA - 2017 Jan 17 SP - 1 EP - 8 KW - amphoteric KW - chemical burn KW - acid burn KW - Prevor KW - alkaloid burn UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826739956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cutaneous+and+ocular+toxicology&rft.atitle=The+safety+and+efficacy+of+Diphoterine+for+ocular+and+cutaneous+burns+in+humans.&rft.au=Lynn%2C+Darren+D%3BZukin%2C+Leonid+M%3BDellavalle%2C+Robert&rft.aulast=Lynn&rft.aufirst=Darren&rft.date=2017-01-17&rft.volume=&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Cutaneous+and+ocular+toxicology&rft.issn=1556-9535&rft_id=info:doi/10.1080%2F15569527.2016.1217423 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-03 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1080/15569527.2016.1217423 ER - TY - JOUR T1 - Acrolein Can Cause Cardiovascular Disease: A Review. AN - 1861461235; 28084565 AB - Acrolein is a highly reactive unsaturated aldehyde that is formed during the burning of gasoline and diesel fuels, cigarettes, woods and plastics. In addition, acrolein is generated during the cooking or frying of food with fats or oils. Acrolein is also used in the synthesis of many organic chemicals and as a biocide in agricultural and industrial water supply systems. The total emissions of acrolein in the United States from all sources are estimated to be 62,660 tons/year. Acrolein is classified by the Environmental Protection Agency as a high-priority air and water toxicant. Acrolein can exert toxic effects following inhalation, ingestion, and dermal exposures that are dose dependent. Cardiovascular tissues are particularly sensitive to the toxic effects of acrolein based primarily on in vitro and in vivo studies. Acrolein can generate free oxygen radical stress in the heart, decrease endothelial nitric oxide synthase phosphorylation and nitric oxide formation, form cytoplasmic and nuclear protein adducts with myocyte and vascular endothelial cell proteins and cause vasospasm. In this manner, chronic exposure to acrolein can cause myocyte dysfunction, myocyte necrosis and apoptosis and ultimately lead to cardiomyopathy and cardiac failure. Epidemiological studies of acrolein exposure and toxicity should be developed and treatment strategies devised that prevent or significantly limit acrolein cardiovascular toxicity. JF - Cardiovascular toxicology AU - Henning, Robert J AU - Johnson, Giffe T AU - Coyle, Jayme P AU - Harbison, Raymond D AD - Department of Environmental and Occupational Health, College of Public Health, University of South Florida, The James A. Haley Hospital, 13201 Bruce B. Downs Blvd, Tampa, FL, 33612-3805, USA. robert.henning@va.gov. ; Department of Environmental and Occupational Health, College of Public Health, University of South Florida, The James A. Haley Hospital, 13201 Bruce B. Downs Blvd, Tampa, FL, 33612-3805, USA. Y1 - 2017/01/13/ PY - 2017 DA - 2017 Jan 13 KW - Protein adducts KW - Free oxygen radicals KW - Unsaturated aldehydes KW - Glutathione depletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861461235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiovascular+toxicology&rft.atitle=Acrolein+Can+Cause+Cardiovascular+Disease%3A+A+Review.&rft.au=Henning%2C+Robert+J%3BJohnson%2C+Giffe+T%3BCoyle%2C+Jayme+P%3BHarbison%2C+Raymond+D&rft.aulast=Henning&rft.aufirst=Robert&rft.date=2017-01-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Cardiovascular+toxicology&rft.issn=1559-0259&rft_id=info:doi/10.1007%2Fs12012-016-9396-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-13 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1007/s12012-016-9396-5 ER - TY - JOUR T1 - Impact of a Pharmacy-Cardiology Collaborative Practice on Dofetilide Safety Monitoring AN - 1859498261; PQ0003971117 AB - Background: Limited studies have been published examining dofetilide's postmarketing use and its recommended monitoring. Objective: To evaluate the impact of a collaborative pharmacy-cardiology antiarrhythmic drug (AAD) monitoring program on dofetilide monitoring. Methods: This retrospective cohort study was performed to assess if a novel monitoring program improved compliance with dofetilide-specific monitoring parameters based on the Food and Drug Administration's Risk Evaluation and Mitigation Strategy. Results: A total of 30 patients were included in the analysis. The monitoring parameters evaluated included electrocardiogram, serum potassium, serum magnesium, and kidney function. The primary outcome evaluated was the composite of these dofetilide monitoring parameters obtained in each cohort. In the standard cohort, 245 of 352 (69.6%) monitoring parameters were completed versus 134 of 136 (98.5%) in the intervention group ( P < 0.05). Conclusion: A collaborative pharmacy-cardiology AAD monitoring program was associated with a significant improvement in dofetilide monitoring. This improvement could potentially translate into enhanced patient safety outcomes, such as prevention of adverse drug reactions and decreased hospitalizations. JF - Annals of Pharmacotherapy AU - Quffa, Lieth H AU - Panna, Mark Jr AU - Kaufmann, Michael R AU - McKillop, Matthew AU - Dietrich, Nicole Maltese AU - Franck, Andrew J AD - 1 .North Florida/South Georgia Veterans Health System, Gainesville, FL, USA, Lieth.quffa@va.gov Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 39 EP - 43 PB - Sage Publications, Inc. VL - 51 IS - 1 SN - 1060-0280, 1060-0280 KW - Toxicology Abstracts KW - pharmaceutical care KW - cardiology KW - antiarrhythmics KW - drug monitoring and drug safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859498261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Pharmacotherapy&rft.atitle=Impact+of+a+Pharmacy-Cardiology+Collaborative+Practice+on+Dofetilide+Safety+Monitoring&rft.au=Quffa%2C+Lieth+H%3BPanna%2C+Mark+Jr%3BKaufmann%2C+Michael+R%3BMcKillop%2C+Matthew%3BDietrich%2C+Nicole+Maltese%3BFranck%2C+Andrew+J&rft.aulast=Quffa&rft.aufirst=Lieth&rft.date=2017-01-01&rft.volume=51&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Annals+of+Pharmacotherapy&rft.issn=10600280&rft_id=info:doi/10.1177%2F1060028016669962 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Number of references - 15 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/1060028016669962 ER - TY - JOUR T1 - Post-training Beliefs, Intentions, and Use of Prolonged Exposure Therapy by Clinicians in the Veterans Health Administration AN - 1857276463 AB - To examine how changes in beliefs during the training process predict adoption of prolonged exposure therapy (PE) by veterans health administration clinicians who received intensive training in this evidence-based treatment. Participants completed a 4-day PE workshop and received expert consultation as they used PE with two or more training cases. Participants were surveyed prior to the workshop, after the workshop, after case consultation (n = 1.034), and 6 months after training (n = 810). Hierarchical regression was used to assess how pre-training factors, and changes in beliefs during different stages of training incrementally predicted post-training intent to use PE and how many patients clinicians were treating with PE 6 months after training. Post-training intent to use PE was high (mean = 6.2, SD = 0.81 on a 1-7 scale), yet most participants treated only 1 or 2 patients at a time with PE. Pre-training factors predicted intent to use and actual use of PE. Changes in beliefs during the workshop had statistically significant yet modest effects on intent and use of PE. Changes in beliefs during case consultation had substantial effects on intent and actual use of PE. Pre-training factors and changes in beliefs during training (especially during case consultation) influence clinicians' adoption of PE. Use of PE was influenced not only by its perceived clinical advantages/disadvantages, but also by contextual factors (working in a PTSD specialty clinic, perceived control over one's schedule, and ability to promote PE to patients and colleagues). JF - Administration and Policy in Mental Health and Mental Health Services Research AU - Ruzek, J I AU - Eftekhari, A AU - Crowley, J AU - Kuhn, E AU - Karlin, B E AU - Rosen, C S AD - Dissemination and Training Division, National Center for PTSD, VA Palo Alto Health Care System, Menlo Park, CA, USA; Palo Alto University, Palo Alto, CA, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA ; Dissemination and Training Division, National Center for PTSD, VA Palo Alto Health Care System, Menlo Park, CA, USA ; Dissemination and Training Division, National Center for PTSD, VA Palo Alto Health Care System, Menlo Park, CA, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA ; Education Development Center Inc., New York, NY, USA; Bloomberg School of Public Health, Johns Hopkins University (Previously affiliated with Mental Health Services, U.S. Department of Veterans Affairs Central Office, Washington, DC), Baltimore, MD, USA ; Dissemination and Training Division, National Center for PTSD, VA Palo Alto Health Care System, Menlo Park, CA, USA; Palo Alto University, Palo Alto, CA, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA Y1 - 2017/01// PY - 2017 DA - Jan 2017 SP - 123 EP - 132 CY - New York PB - Springer Science & Business Media VL - 44 IS - 1 SN - 0894-587X KW - Public Health And Safety KW - Post-training beliefs KW - Intentions KW - Use of prolonged exposure therapy by clinicians in the veterans health administration KW - Posttraumatic stress disorder KW - Training KW - Implementation KW - Veterans KW - Intensive training KW - Military hospitals KW - Contextual factors KW - Evidence based medicine KW - Change agents KW - Exposure therapy KW - Perceived control KW - Consultation KW - Beliefs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1857276463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+and+Mental+Health+Services+Research&rft.atitle=Post-training+Beliefs%2C+Intentions%2C+and+Use+of+Prolonged+Exposure+Therapy+by+Clinicians+in+the+Veterans+Health+Administration&rft.au=Ruzek%2C+J+I%3BEftekhari%2C+A%3BCrowley%2C+J%3BKuhn%2C+E%3BKarlin%2C+B+E%3BRosen%2C+C+S&rft.aulast=Ruzek&rft.aufirst=J&rft.date=2017-01-01&rft.volume=44&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+and+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-015-0689-y LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Administration and Policy in Mental Health and Mental Health Services Research is a copyright of Springer, 2017. N1 - Last updated - 2017-01-16 DO - http://dx.doi.org/10.1007/s10488-015-0689-y ER - TY - JOUR T1 - Phase I Results from a Study of Crizotinib in Combination with Erlotinib in Patients with Advanced Nonsquamous Non-Small Cell Lung Cancer. AN - 1835352360; 27697581 AB - This phase I trial was conducted to determine the safety, maximum tolerated dose (MTD)/recommended phase II dose, and efficacy of crizotinib plus erlotinib in patients with advanced NSCLC. Patients with NSCLC and an Eastern Cooperative Oncology Group performance status of 0 to 2 after failure of one or two prior chemotherapy regimens were eligible. Erlotinib, 100 mg, was given continuously once daily starting between day -14 and -7; crizotinib, 200 mg twice daily (dose level 1) or 150 mg twice daily (dose level -1), was added continuously beginning on day 1 of treatment cycle 1. Potential pharmacokinetic interactions between crizotinib and erlotinib were evaluated. Twenty-seven patients received treatment; 26 received crizotinib plus erlotinib. Frequent adverse events were diarrhea, rash, decreased appetite, and fatigue. Dose-limiting toxicities were dehydration, diarrhea, dry eye, dysphagia, dyspepsia, esophagitis and vomiting. The MTD was crizotinib, 150 mg twice daily, with erlotinib, 100 mg once daily. Crizotinib increased the erlotinib area under the concentration-time curve 1.5-fold (dose level -1) and 1.8-fold (dose level 1). The plasma level of crizotinib appeared to be unaffected by coadministration of erlotinib. Two patients whose tumors harbored activating EGFR mutations achieved confirmed partial responses, one at each crizotinib dose level. The MTD of the combination of crizotinib and erlotinib in patients with advanced NSCLC was crizotinib, 150 mg twice daily, with erlotinib, 100 mg once daily, which is less than the approved dose of either agent. The phase II portion of the study was not initiated. Copyright © 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved. JF - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer AU - Ou, Sai-Hong Ignatius AU - Govindan, Ramaswamy AU - Eaton, Keith D AU - Otterson, Gregory A AU - Gutierrez, Martin E AU - Mita, Alain C AU - Argiris, Athanassios AU - Brega, Nicoletta M AU - Usari, Tiziana AU - Tan, Weiwei AU - Ho, Steffan N AU - Robert, Francisco AD - Chao Family Comprehensive Cancer Center, University of California at Irvine Medical Center, Orange, California. Electronic address: siou@uci.edu. ; Siteman Cancer Center, Washington University, St. Louis, Missouri. ; Seattle Cancer Care Alliance and the University of Washington, Seattle, Washington. ; Ohio State University Comprehensive Cancer Center and the James Cancer Hospital, Columbus, Ohio. ; John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey. ; Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas. ; Pfizer Oncology, Milan, Italy. ; Pfizer Oncology, San Diego, California. ; Birmingham Veterans Administration Hospital, Birmingham, Alabama; University of Alabama-Birmingham Comprehensive Cancer Center, Birmingham, Alabama. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 145 EP - 151 VL - 12 IS - 1 KW - Erlotinib KW - Phase I combination trial KW - EGFR inhibitor KW - MET inhibitor KW - Crizotinib UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835352360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.atitle=Phase+I+Results+from+a+Study+of+Crizotinib+in+Combination+with+Erlotinib+in+Patients+with+Advanced+Nonsquamous+Non-Small+Cell+Lung+Cancer.&rft.au=Ou%2C+Sai-Hong+Ignatius%3BGovindan%2C+Ramaswamy%3BEaton%2C+Keith+D%3BOtterson%2C+Gregory+A%3BGutierrez%2C+Martin+E%3BMita%2C+Alain+C%3BArgiris%2C+Athanassios%3BBrega%2C+Nicoletta+M%3BUsari%2C+Tiziana%3BTan%2C+Weiwei%3BHo%2C+Steffan+N%3BRobert%2C+Francisco&rft.aulast=Ou&rft.aufirst=Sai-Hong&rft.date=2017-01-01&rft.volume=12&rft.issue=1&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.issn=1556-1380&rft_id=info:doi/10.1016%2Fj.jtho.2016.09.131 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jtho.2016.09.131 ER - TY - JOUR T1 - Automatic Classification of Ultrasound Screening Examinations of the Abdominal Aorta AN - 1850783532; PQ0003893062 AB - Our work facilitates the identification of veterans who may be at risk for abdominal aortic aneurysms (AAA) based on the 2007 mandate to screen all veteran patients that meet the screening criteria. The main research objective is to automatically index three clinical conditions: pertinent negative AAA, pertinent positive AAA, and visually unacceptable image exams. We developed and evaluated a ConText-based algorithm with the GATE (General Architecture for Text Engineering) development system to automatically classify 1402 ultrasound radiology reports for AAA screening. Using the results from JAPE (Java Annotation Pattern Engine) transducer rules, we developed a feature vector to classify the radiology reports with a decision table classifier. We found that ConText performed optimally on precision and recall for pertinent negative (0.99 (0.98-0.99), 0.99 (0.99-1.00)) and pertinent positive AAA detection (0.98 (0.95-1.00), 0.97 (0.92-1.00)), and respectably for determination of non-diagnostic image studies (0.85 (0.77-0.91), 0.96 (0.91-0.99)). In addition, our algorithm can determine the AAA size measurements for further characterization of abnormality. We developed and evaluated a regular expression based algorithm using GATE for determining the three contextual conditions: pertinent negative, pertinent positive, and non-diagnostic from radiology reports obtained for evaluating the presence or absence of abdominal aortic aneurysm. ConText performed very well at identifying the contextual features. Our study also discovered contextual trigger terms to detect sub-standard ultrasound image quality. Limitations of performance included unknown dictionary terms, complex sentences, and vague findings that were difficult to classify and properly code. JF - Journal of Digital Imaging AU - Morioka, Craig AU - Meng, Frank AU - Taira, Ricky AU - Sayre, James AU - Zimmerman, Peter AU - Ishimitsu, David AU - Huang, Jimmy AU - Shen, Luyao AU - El-Saden, Suzie AD - Department of Radiology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA, Craig.Morioka@va.gov Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 742 EP - 748 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 29 IS - 6 SN - 0897-1889, 0897-1889 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Aneurysm KW - Classification KW - Aorta KW - Algorithms KW - Language KW - Radiology KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850783532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Digital+Imaging&rft.atitle=Automatic+Classification+of+Ultrasound+Screening+Examinations+of+the+Abdominal+Aorta&rft.au=Morioka%2C+Craig%3BMeng%2C+Frank%3BTaira%2C+Ricky%3BSayre%2C+James%3BZimmerman%2C+Peter%3BIshimitsu%2C+David%3BHuang%2C+Jimmy%3BShen%2C+Luyao%3BEl-Saden%2C+Suzie&rft.aulast=Morioka&rft.aufirst=Craig&rft.date=2016-12-01&rft.volume=29&rft.issue=6&rft.spage=742&rft.isbn=&rft.btitle=&rft.title=Journal+of+Digital+Imaging&rft.issn=08971889&rft_id=info:doi/10.1007%2Fs10278-016-9889-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 23 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Computer programs; Classification; Aneurysm; Aorta; Algorithms; Language; Radiology; Ultrasound DO - http://dx.doi.org/10.1007/s10278-016-9889-6 ER - TY - JOUR T1 - An unusual case of underlying rilpivirine resistance in an antiretroviral-naive man with AIDS AN - 1846415999; PQ0003886022 AB - Primary resistance mutations to second generation HIV non-nucleoside reverse transcriptase inhibitors are rare in HIV-infected persons in the US (estimated at 1.8%). We report an antiretroviral treatment (ART)-naive patient with acquired immunodeficiency syndrome (AIDS) (CD4 cell count 20 cells/mm 3 , viral load 8439 copies/mL), who was infected with HIV-1 sub-type B virus containing a reverse transcriptase mutation, E138A, associated with rilpivirine resistance. Subsequently, he was initiated on a single tablet ART regimen containing an integrase inhibitor and developed immune reconstitution inflammatory syndrome (IRIS), presenting as Mycobacterium avium cervical adenitis. The patient went on to develop rifamycin-induced neutropenia during treatment of his opportunistic infection but later recovered his counts, and remains well on an integrase-based HIV regimen. His case illustrates the growing importance of archived resistance mutations including the less common E138A mutation, as well as the risk and rapid occurrence of IRIS in AIDS patients initiated on integrase inhibitors. JF - International Journal of STD & AIDS AU - Skalweit, Marion J Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1346 EP - 1349 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 United States VL - 27 IS - 14 SN - 0956-4624, 0956-4624 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - HIV KW - AIDS KW - rilpivirine KW - non-nucleoside reverse transcriptase inhibitors KW - primary resistance KW - treatment KW - immune reconstitution inflammatory syndrome KW - Mycobacterium avium cervical adenitis KW - Acquired immune deficiency syndrome KW - Lentivirus KW - Mycobacterium avium KW - Retroviridae KW - Viruses KW - Infection KW - Mutation KW - Antiretroviral agents KW - Sexually transmitted diseases KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846415999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=An+unusual+case+of+underlying+rilpivirine+resistance+in+an+antiretroviral-naive+man+with+AIDS&rft.au=Skalweit%2C+Marion+J&rft.aulast=Skalweit&rft.aufirst=Marion&rft.date=2016-12-01&rft.volume=27&rft.issue=14&rft.spage=1346&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/10.1177%2F0956462416643852 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 18 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Viruses; Infection; Antiretroviral agents; Mutation; Sexually transmitted diseases; Mycobacterium avium; Lentivirus; Retroviridae DO - http://dx.doi.org/10.1177/0956462416643852 ER - TY - JOUR T1 - Effect of Clinical Pharmacist Intervention on Hemoglobin A1C Reduction in Veteran Patients With Type 2 Diabetes in a Rural Setting AN - 1846409057; PQ0003843908 AB - Background: Type 2 diabetes mellitus (T2DM), if left uncontrolled, is associated with significant morbidity and mortality. Patients in rural areas may not have access to adequate resources to successfully treat diabetes. Clinical pharmacists may be utilized to bridge this gap. Objective: To evaluate the impact of a clinical pharmacist on glycemic control in veterans with T2DM enrolled in a rural, outpatient clinic. Methods: Retrospective chart review was performed on veterans with T2DM referred to the pharmacist-managed therapeutic monitoring clinic at a community-based outpatient clinic located in rural Jackson, TN. Patients served as their own controls. Patients with hemoglobin A 1C (A1C) greater than or equal to 8% were included. The primary outcome was A1C change from baseline in patients managed by the clinical pharmacist. Secondary end points included blood pressure, cholesterol, and weight. Results: Of 111 veterans identified as having a A1C greater than or equal to 8% in the pharmacist-managed clinic, 86 met inclusion criteria. At baseline, mean plus or minus SD A1C was 10.5% plus or minus 2.0% (range = 8.7%-16.2%). By the end of the intervention period, mean A1C had decreased by 2.8 percentage points to 7.7% plus or minus 1.4% ( P 10% ( P < 0.001). Improvements in diastolic blood pressure ( P = 0.001), total cholesterol ( P = 0.001), and triglyceride levels ( P = 0.036) were also statistically significant when baseline and intervention period values were compared. Conclusion: Pharmacist interventions at a rural, outpatient clinic had a statistically significant impact on A1C reduction in veterans with T2DM. JF - Annals of Pharmacotherapy AU - Sullivan, Joshua AU - Jett, Bryan Paul AU - Cradick, Mark AU - Zuber, Jeffrey AD - 1 .VAMC Memphis, Clinical Pharmacy Specialist - Ambulatory Care, University of Tennessee College of Pharmacy, TN, USA, josh.sullivan@va.gov Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1023 EP - 1027 PB - Sage Publications, Inc. VL - 50 IS - 12 SN - 1060-0280, 1060-0280 KW - Toxicology Abstracts KW - ambulatory care KW - type 2 diabetes KW - therapeutic monitoring KW - clinical pharmacy KW - pharmaceutical care KW - Diabetes mellitus KW - Hemoglobin KW - Mortality KW - Triglycerides KW - Statistical analysis KW - Cholesterol KW - Blood pressure KW - Morbidity KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846409057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Pharmacotherapy&rft.atitle=Effect+of+Clinical+Pharmacist+Intervention+on+Hemoglobin+A1C+Reduction+in+Veteran+Patients+With+Type+2+Diabetes+in+a+Rural+Setting&rft.au=Sullivan%2C+Joshua%3BJett%2C+Bryan+Paul%3BCradick%2C+Mark%3BZuber%2C+Jeffrey&rft.aulast=Sullivan&rft.aufirst=Joshua&rft.date=2016-12-01&rft.volume=50&rft.issue=12&rft.spage=1023&rft.isbn=&rft.btitle=&rft.title=Annals+of+Pharmacotherapy&rft.issn=10600280&rft_id=info:doi/10.1177%2F1060028016663564 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 11 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Hemoglobin; Diabetes mellitus; Mortality; Triglycerides; Statistical analysis; Cholesterol; Morbidity; Blood pressure DO - http://dx.doi.org/10.1177/1060028016663564 ER - TY - JOUR T1 - Is a Skilled Nursing Facility's Rehospitalization Rate a Valid Quality Measure? AN - 1844983424 AB - Objective To determine whether the observed differences in the risk-adjusted rehospitalization rates across skilled nursing facilities (SNFs) reflect true differences or merely differences in patient severity. Settings Elderly Medicare beneficiaries newly admitted to an SNF following hospitalization. Study Design We used 2009-2012 Medicare data to calculate SNFs' risk-adjusted rehospitalization rate. We then estimated the effect of these rehospitalization rates on the rehospitalization of incident patients in 2013, using an instrumental variable (IV) method and controlling for patient's demographic and clinical characteristics and residential zip code fixed effects. We used the number of empty beds in a patient's proximate SNFs during hospital discharge to create the IV. Principal Findings The risk-adjusted rehospitalization rate varies widely; about one-quarter of the SNFs have a rehospitalization rate lower than 17 percent, and for one-quarter, it is higher than 23 percent. All the IV models result in a robust finding that an increase in a SNF's rehospitalization rate of 1 percentage point over the period 2009-2012 leads to an increase in a patient's likelihood of rehospitalization by 0.8 percentage points in 2013. Conclusions Treatment in SNFs with historically low rehospitalization causally reduces a patient's likelihood of rehospitalization. Observed differences in rehospitalization rates reflect true differences and are not an artifact of selection. JF - Health Services Research AU - Rahman, Momotazur AU - Grabowski, David C AU - Mor, Vincent AU - Norton, Edward C AD - Department of Health Services Policy and Practice, Brown University, Providence, RI ; Department of Health Care Policy, Harvard Medical School, Boston, MA ; Department of Health Services Policy and Practice, Brown University, Providence, RI; Health Services Research Program, Providence Veterans Administration Medical Center, Providence, RI ; Department of Health Management and Policy and Department of Economics, University of Michigan, Ann Arbor, MI; National Bureau of Economic Research, Cambridge, MA ; Department of Health Services Policy and Practice, Brown University, Providence, RI Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 2158 EP - 2175 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 51 IS - 6 SN - 0017-9124 KW - Medical Sciences KW - Elderly people KW - Medicare KW - Demographic aspects KW - Hospital discharged KW - Immediate KW - Hospitalization KW - Severity KW - Beds KW - Empty KW - Nursing KW - Risk adjustment KW - Beneficiaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844983424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Is+a+Skilled+Nursing+Facility%27s+Rehospitalization+Rate+a+Valid+Quality+Measure%3F&rft.au=Rahman%2C+Momotazur%3BGrabowski%2C+David+C%3BMor%2C+Vincent%3BNorton%2C+Edward+C&rft.aulast=Rahman&rft.aufirst=Momotazur&rft.date=2016-12-01&rft.volume=51&rft.issue=6&rft.spage=2158&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12603 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.1111/1475-6773.12603 ER - TY - JOUR T1 - Patient Perception of Enough Time Spent With Provider Is a Mechanism for Improving Women Veterans' Experiences With VA Outpatient Health Care AN - 1837050762 AB - We postulated that associations between two specific provider characteristics, class (nurse practitioner relative to physician) and primary care providers who are proficient and interested in women's health (designated women's provider relative to nondesignated) and overall satisfaction with provider, were mediated through women veterans' perception of enough time spent with the provider. A national patient experience survey was administered to 7,620 women veterans. Multivariable models of overall patient satisfaction with provider were compared with and without the proposed mediator. A structural equation model (SEM) of the mediation of the two provider characteristics was also evaluated. Without the mediator, associations of provider class and designation with overall patient satisfaction were significant. With the proposed mediator, these associations became nonsignificant. An SEM showed that the majority (>80%) of the positive associations between provider class and designation and the outcome were exerted through patient perception of enough time spent with provider. Higher ratings of overall satisfaction with provider exhibited by nurse practitioners and designated women's health providers were exerted through patient perception of enough time spent with provider. Future research should examine what elements of provider training can be developed to improve provider-patient communication and patient satisfaction with their health care. JF - Evaluation & the Health Professions AU - Trentalange, Mark AU - Bielawski, Mark AU - Murphy, Terrence E AU - Lessard, Katarzyna AU - Brandt, Cynthia AU - Bean-Mayberry, Bevanne AU - Maisel, Natalya C AU - Wright, Steven M AU - Allore, Heather AU - Skanderson, Melissa AU - Reyes-Harvey, Evelyn AU - Gaetano, Vera AU - Haskell, Sally AU - Bastian, Lori A AD - Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA ; VA Connecticut Healthcare System, Newington, CT, USA ; VA Connecticut Healthcare System, West Haven, CT, USA ; Veterans Health Administration Health Services Research & Development, Center for the Study of Healthcare Innovation, Implementation and Policy, VA Greater Los Angeles Healthcare System, Sepulveda, CA, USA ; Center for Innovation to Implementation, VA Palo Alto Health Care System, Menlo Park, CA, USA ; Office of Performance Measurement, VHA Office of Analytics & Business Intelligence, Department of Veterans Affairs, Providence, RI, USA ; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA ; Department of Veterans Affairs, Pittsburgh, PA, USA ; Office of Performance Measurement, VHA Office of Analytics & Business Intelligence, Durham, NC, USA ; VA Connecticut HSR&D Pain, Research, Informatics, Multimorbidities, and Education (Prime) Center, West Haven, CT, USA ; Women's Health Services, Patient Care Services, VA Central Office, VA Connecticut Healthcare System Yale School of Medicine, West Haven, CT, USA ; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 460 EP - 474 CY - Beverly Hills PB - SAGE PUBLICATIONS, INC. VL - 39 IS - 4 SN - 0163-2787 KW - Medical Sciences KW - women KW - veterans KW - experiences with health care KW - primary care KW - nurse practitioners KW - structural equation model KW - Patient satisfaction KW - Health care industry KW - Womens health KW - Nurse-Patient communication KW - Nurse practitioners KW - Health professionals KW - Primary health care KW - Veterans KW - Associations KW - Mediation KW - Women's issues UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837050762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evaluation+%26+the+Health+Professions&rft.atitle=Patient+Perception+of+Enough+Time+Spent+With+Provider+Is+a+Mechanism+for+Improving+Women+Veterans%27+Experiences+With+VA+Outpatient+Health+Care&rft.au=Trentalange%2C+Mark%3BBielawski%2C+Mark%3BMurphy%2C+Terrence+E%3BLessard%2C+Katarzyna%3BBrandt%2C+Cynthia%3BBean-Mayberry%2C+Bevanne%3BMaisel%2C+Natalya+C%3BWright%2C+Steven+M%3BAllore%2C+Heather%3BSkanderson%2C+Melissa%3BReyes-Harvey%2C+Evelyn%3BGaetano%2C+Vera%3BHaskell%2C+Sally%3BBastian%2C+Lori+A&rft.aulast=Trentalange&rft.aufirst=Mark&rft.date=2016-12-01&rft.volume=39&rft.issue=4&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Evaluation+%26+the+Health+Professions&rft.issn=01632787&rft_id=info:doi/10.1177%2F0163278716629523 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2016 N1 - Last updated - 2016-11-08 DO - http://dx.doi.org/10.1177/0163278716629523 ER - TY - JOUR T1 - Risk of Recidivism Among Justice-Involved Veterans AN - 1834159132 AB - Empirical research on recidivism risk among justice-involved veterans (JIVs) is limited. Using the risk-need-responsivity model, we conducted a systematic review of research on risk factors for recidivism among JIVs to identify the gaps in this literature and provide recommendations for future research. Substance abuse and indicators of antisociality were consistently linked to justice involvement in veterans; however, the evidence for negative family/marital circumstances and lack of positive school/work involvement was mixed. Several known risk factors for reoffending among civilian offenders (i.e., antisocial cognitions and associates; lack of prosocial activities) were marked by little to no empirical studies among veterans. Posttraumatic stress and traumatic brain injury, particularly when combined with anger and irritability issues, may be veteran-specific risk factors for violent offending. The implications of these findings for policy and practice and challenges to implementing risk assessments with JIVs are discussed. JF - Criminal Justice Policy Review AU - Blonigen, Daniel M AU - Bui, Leena AU - Elbogen, Eric B AU - Blodgett, Janet C AU - Maisel, Natalya C AU - Midboe, Amanda M AU - Asch, Steven M AU - McGuire, James F AU - Timko, Christine AD - VA Palo Alto Health Care System, Menlo Park, CA, USA ; Durham VA Medical Center, NC, USA; University of North Carolina at Chapel Hill, USA ; VA Palo Alto Health Care System, Menlo Park, CA, USA; Stanford University School of Medicine, CA, USA ; Veterans Health Administration, Washington, DC, USA ; VA Palo Alto Health Care System, Menlo Park, CA, USA Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 812 EP - 837 CY - Thousand Oaks PB - SAGE PUBLICATIONS, INC. VL - 27 IS - 8 SN - 0887-4034 KW - Law--Criminal Law KW - recidivism KW - risk factors KW - assessment KW - veterans KW - risk-need-responsivity KW - Justice KW - Participation KW - Veterans KW - Recidivism KW - Family Work Relationship KW - Risk KW - Research KW - Substance Abuse KW - Empirical Methods KW - Offenders KW - Family School Relationship KW - Indexes (Measures) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1834159132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Criminal+Justice+Policy+Review&rft.atitle=Risk+of+Recidivism+Among+Justice-Involved+Veterans&rft.au=Blonigen%2C+Daniel+M%3BBui%2C+Leena%3BElbogen%2C+Eric+B%3BBlodgett%2C+Janet+C%3BMaisel%2C+Natalya+C%3BMidboe%2C+Amanda+M%3BAsch%2C+Steven+M%3BMcGuire%2C+James+F%3BTimko%2C+Christine&rft.aulast=Blonigen&rft.aufirst=Daniel&rft.date=2016-12-01&rft.volume=27&rft.issue=8&rft.spage=812&rft.isbn=&rft.btitle=&rft.title=Criminal+Justice+Policy+Review&rft.issn=08874034&rft_id=info:doi/10.1177%2F0887403414562602 LA - English DB - PAIS Index N1 - Copyright - © 2014 SAGE Publications N1 - Last updated - 2016-11-01 DO - http://dx.doi.org/10.1177/0887403414562602 ER - TY - JOUR T1 - Machine learning to predict rapid progression of carotid atherosclerosis in patients with impaired glucose tolerance AN - 1827917584; PQ0003688468 AB - Prediabetes is a major epidemic and is associated with adverse cardio-cerebrovascular outcomes. Early identification of patients who will develop rapid progression of atherosclerosis could be beneficial for improved risk stratification. In this paper, we investigate important factors impacting the prediction, using several machine learning methods, of rapid progression of carotid intima-media thickness in impaired glucose tolerance (IGT) participants. In the Actos Now for Prevention of Diabetes (ACT NOW) study, 382 participants with IGT underwent carotid intima-media thickness (CIMT) ultrasound evaluation at baseline and at 15-18 months, and were divided into rapid progressors (RP, n=39, 58 plus or minus 17.5 mu M change) and non-rapid progressors (NRP, n=343, 5.8 plus or minus 20 mu M change, p<0.001 versus RP). To deal with complex multi-modal data consisting of demographic, clinical, and laboratory variables, we propose a general data-driven framework to investigate the ACT NOW dataset. In particular, we first employed a Fisher Score-based feature selection method to identify the most effective variables and then proposed a probabilistic Bayes-based learning method for the prediction. Comparison of the methods and factors was conducted using area under the receiver operating characteristic curve (AUC) analyses and Brier score. The experimental results show that the proposed learning methods performed well in identifying or predicting RP. Among the methods, the performance of Naive Bayes was the best (AUC 0.797, Brier score 0.085) compared to multilayer perceptron (0.729, 0.086) and random forest (0.642, 0.10). The results also show that feature selection has a significant positive impact on the data prediction performance. By dealing with multi-modal data, the proposed learning methods show effectiveness in predicting prediabetics at risk for rapid atherosclerosis progression. The proposed framework demonstrated utility in outcome prediction in a typical multidimensional clinical dataset with a relatively small number of subjects, extending the potential utility of machine learning approaches beyond extremely large-scale datasets. JF - Eurasip Journal on Bioinformatics and Systems Biology AU - Hu, Xia AU - Reaven, Peter D AU - Saremi, Aramesh AU - Liu, Ninghao AU - Abbasi, Mohammad Ali AU - Liu, Huan AU - Migrino, Raymond Q AD - Arizona State University, Tempe, AZ, USA, raymond.migrino@va.gov Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1 EP - 7 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 2016 IS - 1 KW - Biotechnology and Bioengineering Abstracts KW - Learning KW - Data processing KW - Epidemics KW - Bayesian analysis KW - Forests KW - Arteriosclerosis KW - Demography KW - Diabetes mellitus KW - Glucose tolerance KW - Learning algorithms KW - Bioinformatics KW - Ultrasound KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827917584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eurasip+Journal+on+Bioinformatics+and+Systems+Biology&rft.atitle=Machine+learning+to+predict+rapid+progression+of+carotid+atherosclerosis+in+patients+with+impaired+glucose+tolerance&rft.au=Hu%2C+Xia%3BReaven%2C+Peter+D%3BSaremi%2C+Aramesh%3BLiu%2C+Ninghao%3BAbbasi%2C+Mohammad+Ali%3BLiu%2C+Huan%3BMigrino%2C+Raymond+Q&rft.aulast=Hu&rft.aufirst=Xia&rft.date=2016-12-01&rft.volume=2016&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Eurasip+Journal+on+Bioinformatics+and+Systems+Biology&rft.issn=1687-4153&rft_id=info:doi/10.1186%2Fs13637-016-0049-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 24 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Demography; Learning; Epidemics; Data processing; Bayesian analysis; Forests; Glucose tolerance; Bioinformatics; Arteriosclerosis; Learning algorithms; Ultrasound DO - http://dx.doi.org/10.1186/s13637-016-0049-6 ER - TY - JOUR T1 - Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis. AN - 1826704402; 27320325 AB - Only a minority of heavy drinking individuals develop alcoholic hepatitis (AH), for unclear reasons. We analyzed data from the Translational Research and Evolving Alcoholic Hepatitis Treatment cohort, consisting of subjects who drink heavily with normal results from liver tests (controls) and patients with AH. We examined risk factors for the development of AH including body mass index (BMI), drinking pattern and quantity, and sex. We compared data from 145 patients with AH and 124 controls based on BMI when they joined the cohort; groups were matched for sex and race. Drinking patterns were assessed using the timeline followback method, the Alcohol Use Disorders Identification Test, and the National Institute of Alcohol Abuse and Alcoholism 6-question survey. We performed univariable and multivariable analyses to assess the effects of these factors and their interaction in increasing the risk for AH. We also explored the association between PNPLA3 variants and AH. Cases with AH were older (47 vs 44 y; P = .03). For nearly all measures of quantity of alcohol consumed or frequency of binge drinking, controls drank more heavily than cases with AH. We did not find an association between BMI, sex, drinking patterns, and the presence of AH. Age and BMI were independent predictors for the severity of AH. When we analyzed cases and controls of European ancestry, the PNPLA3 single-nucleotide polymorphism rs738409 was associated with risk for AH (odds ratio, 1.89; P = .007). Compared with heavy drinkers without liver disease, subjects with AH consumed lower levels of alcohol and had less binge drinking, suggesting an increased sensitivity to the toxic effects of alcohol. The risk for AH may be associated with the PNPLA3 rs738409 polymorphism. Copyright © 2016 AGA Institute. Published by Elsevier Inc. All rights reserved. JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association AU - Liangpunsakul, Suthat AU - Puri, Puneet AU - Shah, Vijay H AU - Kamath, Patrick AU - Sanyal, Arun AU - Urban, Thomas AU - Ren, Xiaowei AU - Katz, Barry AU - Radaeva, Svetlana AU - Chalasani, Naga AU - Crabb, David W AU - Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium AD - Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Medicine, Roudebush Veterans Administration Medical Center, Indianapolis, Indiana. Electronic address: sliangpu@iupui.edu. ; Division of Gastroenterology and Hepatology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia. ; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. ; Division of Pharmacotherapy and Experimental Therapeutics, Center for Pharmacogenomics and Individualized Therapy, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina. ; Department of Biostatistics, Richard M. Fairbanks School of Public Health, Indiana University School of Medicine, Indianapolis, Indiana. ; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland. ; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana. ; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Eskenazi Health, Indianapolis, Indiana. ; Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1831 EP - 1838.e3 VL - 14 IS - 12 KW - Body Weight KW - Gender KW - TLFB KW - Alcoholic Hepatitis KW - TREAT KW - Alcohol Intake UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826704402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+gastroenterology+and+hepatology+%3A+the+official+clinical+practice+journal+of+the+American+Gastroenterological+Association&rft.atitle=Effects+of+Age%2C+Sex%2C+Body+Weight%2C+and+Quantity+of+Alcohol+Consumption+on+Occurrence+and+Severity+of+Alcoholic+Hepatitis.&rft.au=Liangpunsakul%2C+Suthat%3BPuri%2C+Puneet%3BShah%2C+Vijay+H%3BKamath%2C+Patrick%3BSanyal%2C+Arun%3BUrban%2C+Thomas%3BRen%2C+Xiaowei%3BKatz%2C+Barry%3BRadaeva%2C+Svetlana%3BChalasani%2C+Naga%3BCrabb%2C+David+W%3BTranslational+Research+and+Evolving+Alcoholic+Hepatitis+Treatment+Consortium&rft.aulast=Liangpunsakul&rft.aufirst=Suthat&rft.date=2016-12-01&rft.volume=14&rft.issue=12&rft.spage=1831&rft.isbn=&rft.btitle=&rft.title=Clinical+gastroenterology+and+hepatology+%3A+the+official+clinical+practice+journal+of+the+American+Gastroenterological+Association&rft.issn=1542-7714&rft_id=info:doi/10.1016%2Fj.cgh.2016.05.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.cgh.2016.05.041 ER - TY - JOUR T1 - Identification of novel small molecules that bind to the loop2 region of sclerostin - an in silico computational analysis. AN - 1826722878; 27429110 AB - The goal of this study was to identify small molecular weight compounds that bind to sclerostin using in-silico methods because of the established importance of sclerostin-based therapies for the treatment of disease characterized by low bone mass. The zinc database (Zdb) revealed that nine potential molecules bind to the loop2 region (functional site) of sclerostin with ADME/T properties that are within an acceptable range defined for human use. Compounds 30160056 and 56871042 showed the highest docking score. Density functional theory (by HOMO, LUMO and MESP analysis) and MM/GBSA analysis showed that four compounds 30160056, 56871042, 72112226 and 43920281 exhibit high stability among the nine small molecules identified. Induced Docking Fit and Pymol software analyses revealed that the identified compounds differ in the interaction with amino acids in the loop2 region of sclerostin. Six compound exhibited interaction with Ile95 and 2 compounds with Asn93, an amino acid in the loop2 region known to be involved in sclerostin's inhibitory effect, suggesting that the identified compounds have the potential to bind and neutralize sclerostin function. Furthermore, compound 43920281 showed a low risk of toxicity and drug-like characteristic features compared to all nine identified compounds. In conclusion, in silico analysis identified a novel compound 43920281 as a potent anti-sclerostin therapeutic for drug development for the treatment of osteoporosis. JF - Physiological research AU - Muthusamy, K AU - Mohan, S AU - Nagamani, S AU - Kesavan, C AD - Department of Bioinformatics, Alagappa University, Karaikudi, India; Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Research Service, Loma Linda, CA, USA. Chandrasekhar.Kesavan@va.gov. Y1 - 2016/11/23/ PY - 2016 DA - 2016 Nov 23 SP - 871 EP - 878 VL - 65 IS - 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826722878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiological+research&rft.atitle=Identification+of+novel+small+molecules+that+bind+to+the+loop2+region+of+sclerostin+-+an+in+silico+computational+analysis.&rft.au=Muthusamy%2C+K%3BMohan%2C+S%3BNagamani%2C+S%3BKesavan%2C+C&rft.aulast=Muthusamy&rft.aufirst=K&rft.date=2016-11-23&rft.volume=65&rft.issue=5&rft.spage=871&rft.isbn=&rft.btitle=&rft.title=Physiological+research&rft.issn=1802-9973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Evaluation of a Potential Interaction Between New Regimens to Treat Hepatitis C and Warfarin AN - 1837341539; PQ0003740510 AB - Objective: New regimens to treat hepatitis C virus infection have expanded the eligible patient population to include more patients receiving concurrent warfarin. The primary objective of this study was to assess whether a drug interaction occurs when these regimens are added to warfarin therapy. Methods: This was a retrospective cohort design using a nationwide database of the Veterans Affairs Health System. Patients on warfarin therapy treated with sofosbuvir or ombitasvir, paritaprevir-ritonavir, and dasabuvir (OBV-PTV/r-DSV) from March 2014 through October 2015 were identified. The warfarin dose response was calculated using a warfarin sensitivity index (WSI) defined as the steady-state INR divided by the mean daily warfarin dose. The primary outcome was the change in WSI from hepatitis C treatment initiation to completion. Results: The final sample consisted of 271 patients. The WSI decreased 23% from a mean baseline value of 0.53 to 0.39 (decrease of 0.14; 95% CI = 0.11 to 0.16; P < 0.001). OBV-PTV/r-DSV produced a significantly greater decrease than any sofosbuvir regimen. Concurrent ribavirin accounted for an additional decrease in warfarin sensitivity of -0.09 (95% CI = -0.06 to -0.12; P < 0.001). The percentage of subtherapeutic INR results increased from 26% prior to hepatitis C treatment to 58% during treatment. Conclusions: Results indicate a clinically significant reduction in warfarin dose-response when hepatitis C treatment regimens were added to warfarin. They were most profound with OBV-PTV/r-DSV. Ribavirin was associated with an additive effect. Clinicians should be aware of this potential drug interaction to closely monitor and minimize subtherapeutic levels of anticoagulation. JF - Annals of Pharmacotherapy AU - DeCarolis, Douglas D AU - Westanmo, Anders D AU - Chen, Yi-Chie AU - Boese, Amanda L AU - Walquist, Mary A AU - Rector, Thomas S AD - 1 .Minneapolis VA Health Care System, Minneapolis, MN, USA, douglas.decarolis@va.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 909 EP - 917 PB - Sage Publications, Inc. VL - 50 IS - 11 SN - 1060-0280, 1060-0280 KW - Virology & AIDS Abstracts; Toxicology Abstracts KW - anticoagulants KW - anticoagulation KW - antivirals KW - cytochrome P-450 interactions KW - drug interactions KW - gastroenterology KW - hepatitis C KW - pharmacokinetics KW - therapeutic monitoring KW - warfarin KW - Drug interaction KW - Databases KW - Hepatitis C virus KW - Ribavirin KW - Warfarin KW - Hepatitis C KW - Infection KW - X 24330:Agrochemicals KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837341539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Pharmacotherapy&rft.atitle=Evaluation+of+a+Potential+Interaction+Between+New+Regimens+to+Treat+Hepatitis+C+and+Warfarin&rft.au=DeCarolis%2C+Douglas+D%3BWestanmo%2C+Anders+D%3BChen%2C+Yi-Chie%3BBoese%2C+Amanda+L%3BWalquist%2C+Mary+A%3BRector%2C+Thomas+S&rft.aulast=DeCarolis&rft.aufirst=Douglas&rft.date=2016-11-01&rft.volume=50&rft.issue=11&rft.spage=909&rft.isbn=&rft.btitle=&rft.title=Annals+of+Pharmacotherapy&rft.issn=10600280&rft_id=info:doi/10.1177%2F1060028016660325 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 44 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Databases; Drug interaction; Ribavirin; Hepatitis C; Warfarin; Infection; Hepatitis C virus DO - http://dx.doi.org/10.1177/1060028016660325 ER - TY - JOUR T1 - What Is the Critical Value of Glenoid Bone Loss at Which Soft Tissue Bankart Repair Does Not Restore Glenohumeral Translation, Restricts Range of Motion, and Leads to Abnormal Humeral Head Position? AN - 1837318707; PQ0003816088 AB - Background: A general consensus has been formed that glenoid bone loss greater than 20% to 25% is the critical amount at which bony augmentation procedures are needed; however, recent clinical results suggest that the critical levels must be reconsidered to lower values. Purpose: This study aimed to find the critical value of anterior glenoid bone loss when a soft tissue repair is not adequate to restore anterior-inferior glenohumeral translation, rotational range of motion, or humeral head position using a biomechanical anterior shoulder instability model. Study Design: Controlled laboratory study. Methods: Eight cadaveric shoulders were tested with a customized shoulder testing system. Range of motion, translation, and humeral head position were measured at 60 degree of glenohumeral abduction in the scapular plane under a total of 40-N rotator cuff muscle loading in the following 11 conditions: intact; soft tissue Bankart lesion and repair; Bankart lesion with 10%, 15%, 20%, and 25% glenoid bone defects based on the largest anteroposterior width of the glenoid; and soft tissue Bankart repair for each respective glenoid defect. Serial osteotomies for each percentage of bone loss were made parallel to the long axis of the glenoid. Results: There was significantly decreased external rotation (121.2 degree plus or minus 2.8 degree to 113.5 degree plus or minus 3.3 degree ; P = .004), increased anteroinferior translation with an externally applied load (3.0 plus or minus 1.2 mm to 7.5 plus or minus 1.1 mm at 20 N; P = .008), and increased posterior (0.2 plus or minus 0.6 mm to 2.7 plus or minus 0.8 mm; P = .049) and inferior shift (2.9 plus or minus 0.7 mm to 6.6 plus or minus 1.1 mm; P = .018) of the humeral head apex in the position of maximum external rotation after soft tissue Bankart repair of a 15% glenoid defect compared with the repair of a Bankart lesion without a glenoid defect, respectively. Conclusion: Glenoid defects of 15% or more of the largest anteroposterior glenoid width should be considered the critical bone loss amount at which soft tissue repair cannot restore glenohumeral translation, restricts rotational range of motion, and leads to abnormal humeral head position. Clinical Relevance: The critical level of anterior glenoid bone loss at which bony restorations should be considered is closer to 15% of the largest anteroposterior width of glenoid for defects perpendicular to the superoinferior glenoid axis, which is lower than the commonly accepted threshold of 20% to 25%. JF - American Journal of Sports Medicine AU - Shin, Sang-Jin AU - Koh, Yong Won AU - Bui, Christopher AU - Jeong, Woong Kyo AU - Akeda, Masaki AU - Cho, Nam Su AU - McGarry, Michelle H AU - Lee, Thay Q AD - * .Department of Orthopaedic Surgery, Ewha Womans University, Seoul, Korea, tqlee@med.va.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 2784 EP - 2791 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 44 IS - 11 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - shoulder instability KW - Bankart lesion KW - Bankart repair KW - biomechanics KW - glenoid bone loss KW - Measurement KW - Bones KW - Flexibility KW - Muscles KW - Rotator cuff KW - Shoulders KW - Work load KW - Sports medicine KW - Biomechanics KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837318707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=What+Is+the+Critical+Value+of+Glenoid+Bone+Loss+at+Which+Soft+Tissue+Bankart+Repair+Does+Not+Restore+Glenohumeral+Translation%2C+Restricts+Range+of+Motion%2C+and+Leads+to+Abnormal+Humeral+Head+Position%3F&rft.au=Shin%2C+Sang-Jin%3BKoh%2C+Yong+Won%3BBui%2C+Christopher%3BJeong%2C+Woong+Kyo%3BAkeda%2C+Masaki%3BCho%2C+Nam+Su%3BMcGarry%2C+Michelle+H%3BLee%2C+Thay+Q&rft.aulast=Shin&rft.aufirst=Sang-Jin&rft.date=2016-11-01&rft.volume=44&rft.issue=11&rft.spage=2784&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F0363546516656367 LA - English DB - Physical Education Index N1 - Date revised - 2016-11-01 N1 - Number of references - 30 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Measurement; Bones; Flexibility; Muscles; Rotator cuff; Work load; Shoulders; Sports medicine; Biomechanics DO - http://dx.doi.org/10.1177/0363546516656367 ER - TY - JOUR T1 - Potential Role of DARC-Chemokine Interaction in the Recruitment of Osteoclast Precursors in Response to Bacterial Lipopolysaccharide Challenge AN - 1837317859; PQ0003740916 AB - Duffy antigen receptor for chemokines (DARC) binds to a number of pro-inflammatory chemokines, and since chemokines are known to regulate trafficking of osteoclast (OC) precursors, we predicted that DARC would regulate OC recruitment to sites of inflammation by modulating chemokine activity. To test this hypothesis, we evaluated the mRNA expression of Darc and the chemokines known to bind to DARC, in endothelial cells treated with bacterial lipopolysaccharide (LPS). The mRNA expression of Mcp-1, Rantes, Darc and Ccr5 was significantly increased in endothelial cells in response to LPS treatment. Blocking the function of DARC with neutralizing antibody partially abrogated the effect of LPS on the mRNA expression of Mcp-1 and Rantes. In vivo, mice with targeted disruption of Darc gene (Darc-KO) and control wild-type (WT) mice were used to assess the role of DARC in response to single LPS application on the top of parietal bones. Five hours post-LPS injection, local expression of Cd14 mRNA (a marker of inflammatory monocytes) was significantly increased in both lines of mice. However, the magnitude of increase was greater in WT mice compared with Darc-KO mice suggesting a role for DARC in mediating the recruitment of monocytes in response to LPS. Histological staining for tartrate-resistant acid phosphatase (TRAP) in calvaria sections taken from the injection sites revealed a significant reduction in TRAP-labeled surface per bone surface in response to LPS in Darc-KO mice compared with WT mice. Based on these findings, we concluded that DARC regulates recruitment of OC precursors at the inflammation site, probably through regulation of chemokines transcytosis across endothelial cell barrier. JF - Calcified Tissue International AU - Alemi, Fatemeh AU - Elgendy, Mohamed AU - Edderkaoui, Bouchra AD - Musculoskeletal Disease Center, Research Service, Jerry L Pettis Memorial Veterans Administration Medical Center, 11201 Benton St. (151), Loma Linda, CA, 92357, USA, Bouchra.Edderkaoui@va.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 481 EP - 488 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 99 IS - 5 SN - 0171-967X, 0171-967X KW - Microbiology Abstracts B: Bacteriology; Calcium & Calcified Tissue Abstracts KW - Bacteria KW - Chemokines KW - Monocyte chemoattractant protein 1 KW - Osteoclasts KW - RANTES KW - CCR5 protein KW - Calvaria KW - CD14 antigen KW - Inflammation KW - Endothelial cells KW - Gene expression KW - Antibodies KW - Duffy antigen KW - Acid phosphatase (tartrate-resistant) KW - Osteoprogenitor cells KW - Lipopolysaccharides KW - Monocytes KW - parietal bone KW - J 02410:Animal Diseases KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837317859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Calcified+Tissue+International&rft.atitle=Potential+Role+of+DARC-Chemokine+Interaction+in+the+Recruitment+of+Osteoclast+Precursors+in+Response+to+Bacterial+Lipopolysaccharide+Challenge&rft.au=Alemi%2C+Fatemeh%3BElgendy%2C+Mohamed%3BEdderkaoui%2C+Bouchra&rft.aulast=Alemi&rft.aufirst=Fatemeh&rft.date=2016-11-01&rft.volume=99&rft.issue=5&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Calcified+Tissue+International&rft.issn=0171967X&rft_id=info:doi/10.1007%2Fs00223-016-0170-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 20 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Chemokines; Monocyte chemoattractant protein 1; Osteoclasts; RANTES; CCR5 protein; CD14 antigen; Calvaria; Inflammation; Gene expression; Endothelial cells; Antibodies; Duffy antigen; Osteoprogenitor cells; Acid phosphatase (tartrate-resistant); Lipopolysaccharides; Monocytes; parietal bone; Bacteria DO - http://dx.doi.org/10.1007/s00223-016-0170-2 ER - TY - JOUR T1 - Coronary angiography and failure to rescue after postoperative myocardial infarction in patients with coronary stents undergoing noncardiac surgery AN - 1837317853; PQ0003764195 AB - Background We evaluated coronary angiography use among patients with coronary stents suffering postoperative myocardial infarction (MI) and the association with mortality. Methods Patients with prior coronary stenting who underwent inpatient noncardiac surgery in Veterans Affairs hospitals between 2000 and 2012 and experienced postoperative MI were identified. Predictors of 30-day post-MI mortality were evaluated. Results Following 12,096 operations, 353 (2.9%) patients had postoperative MI and 58 (16.4%) died. Post-MI coronary angiography was performed in 103 (29.2%) patients. Coronary angiography was not associated with 30-day mortality (odds ratio [OR]: .70, 95% CI: .35-1.42). Instead, 30-day mortality was predicted by revised cardiac risk index greater than or equal to 3 (OR 1.91, 95% CI: 1.04-3.50) and prior bare metal stent (OR 2.12, 95% CI: 1.04-4.33). Conclusions Less than one-third of patients with coronary stents suffering postoperative MI underwent coronary angiography. Significant predictors of mortality were higher revised cardiac risk index and prior bare metal stent. These findings highlight the importance of comorbidities in predicting mortality following postoperative MI. JF - American Journal of Surgery AU - Hollis, Robert H AU - Holcomb, Carla N AU - Valle, Javier A AU - Smith, Burke P AU - DeRussy, Aerin J AU - Graham, Laura A AU - Richman, Joshua S AU - Itani, Kamal MF AU - Maddox, Thomas M AU - Hawn, Mary T AD - Center for Surgical, Medical Acute Care Research and Transitions (C-SMART), Department of Surgery, Birmingham Veterans Administration Hospital, University of Alabama at Birmingham, Birmingham, AL, USA Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 814 EP - 822.e1 PB - Elsevier B.V., Radarweg 29 Amsterdam 1043 NX Netherlands VL - 212 IS - 5 SN - 0002-9610, 0002-9610 KW - Biotechnology and Bioengineering Abstracts KW - Postoperative myocardial infarction KW - Coronary stent KW - Coronary angiography KW - Postoperative mortality KW - Failure to rescue KW - Cardiac risk index KW - Heart KW - Mortality KW - Metals KW - Angiography KW - Implants KW - Surgery KW - Risk factors KW - Myocardial infarction KW - Hospitals KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837317853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Surgery&rft.atitle=Coronary+angiography+and+failure+to+rescue+after+postoperative+myocardial+infarction+in+patients+with+coronary+stents+undergoing+noncardiac+surgery&rft.au=Hollis%2C+Robert+H%3BHolcomb%2C+Carla+N%3BValle%2C+Javier+A%3BSmith%2C+Burke+P%3BDeRussy%2C+Aerin+J%3BGraham%2C+Laura+A%3BRichman%2C+Joshua+S%3BItani%2C+Kamal+MF%3BMaddox%2C+Thomas+M%3BHawn%2C+Mary+T&rft.aulast=Hollis&rft.aufirst=Robert&rft.date=2016-11-01&rft.volume=212&rft.issue=5&rft.spage=814&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Surgery&rft.issn=00029610&rft_id=info:doi/10.1016%2Fj.amjsurg.2016.07.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 16 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Heart; Metals; Mortality; Angiography; Risk factors; Surgery; Implants; Myocardial infarction; Hospitals DO - http://dx.doi.org/10.1016/j.amjsurg.2016.07.023 ER - TY - JOUR T1 - Perspectives on expedited partner therapy for chlamydia: a survey of health care providers AN - 1837303961; PQ0003812314 AB - There is a lack of research on health care providers' use of and perspectives on expedited partner therapy in a state where expedited partner therapy is not prohibited or explicitly allowed. The aim of our study was to understand if and how health care providers use expedited partner therapy, if specific demographic factors and knowledge contribute to increased use of expedited partner therapy, and to describe barriers and facilitators to the use of expedited partner therapy in Pittsburgh, Pennsylvania. A convenience sample of 112 health care providers from diverse disciplines who treat young women at risk for chlamydia completed an online survey. About 11% of health care providers used expedited partner therapy consistently. Those who self-reported that they were knowledgeable about expedited partner therapy were more likely to use expedited partner therapy (73% vs. 49%, p =.009) as were those who said no or were unsure about their institution's guidelines for expedited partner therapy (35% vs. 22%, p =0.01) (62% vs. 57%, p =0.01). The most commonly reported facilitator of expedited partner therapy was having clear legal guidelines (86%). This study finds that in a setting where expedited partner therapy is not expressly permitted, health care providers still use the practice but also experience barriers that limit uptake. Legislation expressly endorsing expedited partner therapy in the state and in medical institutions is needed to increase expedited partner therapy use. JF - International Journal of STD & AIDS AU - Rosenfeld, E A AU - Marx, J AU - Terry, MA AU - Stall, R AU - Flatt, J AU - Borrero, S AU - Miller, E AD - 1 .VA Women's Health, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA, Elian.rosenfeld@va.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1180 EP - 1186 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 United States VL - 27 IS - 13 SN - 0956-4624, 0956-4624 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Expedited partner therapy KW - providers KW - survey KW - sexually transmitted infection KW - treatment KW - Acquired immune deficiency syndrome KW - Guidelines KW - Demography KW - Health care KW - Risk factors KW - USA, Pennsylvania KW - Sexually transmitted diseases KW - Internet KW - Legislation KW - Chlamydia KW - V 22360:AIDS and HIV KW - J 02400:Human Diseases KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837303961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=Perspectives+on+expedited+partner+therapy+for+chlamydia%3A+a+survey+of+health+care+providers&rft.au=Rosenfeld%2C+E+A%3BMarx%2C+J%3BTerry%2C+MA%3BStall%2C+R%3BFlatt%2C+J%3BBorrero%2C+S%3BMiller%2C+E&rft.aulast=Rosenfeld&rft.aufirst=E&rft.date=2016-11-01&rft.volume=27&rft.issue=13&rft.spage=1180&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/10.1177%2F0956462415610689 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 29 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Demography; Legislation; Internet; Acquired immune deficiency syndrome; Health care; Risk factors; Guidelines; Sexually transmitted diseases; Chlamydia; USA, Pennsylvania DO - http://dx.doi.org/10.1177/0956462415610689 ER - TY - JOUR T1 - The Scourge of the Spurge Family-An Imitator of Rhus Dermatitis. AN - 1835519592; 27775975 AB - The Euphorbiaceae family (commonly known as "spurge") is a large, diverse, and widely distributed family of plants that encompass around 300 genera and more than 8000 species. Their attractiveness and hearty nature have made them popular for both indoor ornamentation and outdoor landscaping. Despite their ubiquity, the potential to cause irritant contact dermatitis (ICD) is often overlooked in favor of more notorious causes of phytodermatitis, namely, Toxicodendron species and nettles. We examined case reports spanning 40 years and discovered that spurge-induced ICD tends to befall children and middle-aged adults who unwittingly encounter the plant through play or horticulture, respectively. Clinical presentation is pleomorphic. Erythema, edema, burning, vesicles, and pruritus of acute onset and rapid resolution are frequently observed. We present a classic case of ICD in a 12-year-old girl after exposure to Euphorbia myrsinites and review the literature on phytodermatitis caused by members of the Euphorbiaceae family. JF - Dermatitis : contact, atopic, occupational, drug AU - Huerth, Kimberly A AU - Hawkes, Jason E AU - Meyer, Laurence J AU - Powell, Douglas L AD - From the *University at Buffalo School of Medicine, New York, NY; †The University of Utah Department of Dermatology, Salt Lake City; and ‡Veterans Administration Hospital, Salt Lake City, UT. PY - 2016 SP - 372 EP - 381 VL - 27 IS - 6 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835519592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dermatitis+%3A+contact%2C+atopic%2C+occupational%2C+drug&rft.atitle=The+Scourge+of+the+Spurge+Family-An+Imitator+of+Rhus+Dermatitis.&rft.au=Huerth%2C+Kimberly+A%3BHawkes%2C+Jason+E%3BMeyer%2C+Laurence+J%3BPowell%2C+Douglas+L&rft.aulast=Huerth&rft.aufirst=Kimberly&rft.date=2016-11-01&rft.volume=27&rft.issue=6&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=Dermatitis+%3A+contact%2C+atopic%2C+occupational%2C+drug&rft.issn=2162-5220&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APCMin/+ Mice. AN - 1835353279; 27638841 AB - Chronic intestinal inflammation accompanies familial adenomatous polyposis (FAP) and is a major risk factor for colorectal cancer in patients with this disease, but the cause of such inflammation is unknown. Because retinoic acid (RA) plays a critical role in maintaining immune homeostasis in the intestine, we hypothesized that altered RA metabolism contributes to inflammation and tumorigenesis in FAP. To assess this hypothesis, we analyzed RA metabolism in the intestines of patients with FAP as well as APCMin/+ mice, a model that recapitulates FAP in most respects. We also investigated the impact of intestinal RA repletion and depletion on tumorigenesis and inflammation in APCMin/+ mice. Tumors from both FAP patients and APCMin/+ mice displayed striking alterations in RA metabolism that resulted in reduced intestinal RA. APCMin/+ mice placed on a vitamin A-deficient diet exhibited further reductions in intestinal RA with concomitant increases in inflammation and tumor burden. Conversely, restoration of RA by pharmacologic blockade of the RA-catabolizing enzyme CYP26A1 attenuated inflammation and diminished tumor burden. To investigate the effect of RA deficiency on the gut immune system, we studied lamina propria dendritic cells (LPDC) because these cells play a central role in promoting tolerance. APCMin/+ LPDCs preferentially induced Th17 cells, but reverted to inducing Tregs following restoration of intestinal RA in vivo or direct treatment of LPDCs with RA in vitro These findings demonstrate the importance of intestinal RA deficiency in tumorigenesis and suggest that pharmacologic repletion of RA could reduce tumorigenesis in FAP patients. Cancer Immunol Res; 4(11); 917-26. ©2016 AACR. ©2016 American Association for Cancer Research. JF - Cancer immunology research AU - Penny, Hweixian Leong AU - Prestwood, Tyler R AU - Bhattacharya, Nupur AU - Sun, Fionna AU - Kenkel, Justin A AU - Davidson, Matthew G AU - Shen, Lei AU - Zuniga, Luis A AU - Seeley, E Scott AU - Pai, Reetesh AU - Choi, Okmi AU - Tolentino, Lorna AU - Wang, Jinshan AU - Napoli, Joseph L AU - Engleman, Edgar G AD - Department of Pathology, Stanford University School of Medicine (Blood Center), Palo Alto, California. ; Department of Immunology, Veterans Administration Hospital, Palo Alto, California. ; Department of Pathology, Stanford University, Stanford, California. ; Department of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, California. ; Department of Pathology, Stanford University School of Medicine (Blood Center), Palo Alto, California. edengleman@stanford.edu. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 917 EP - 926 VL - 4 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835353279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+immunology+research&rft.atitle=Restoring+Retinoic+Acid+Attenuates+Intestinal+Inflammation+and+Tumorigenesis+in+APCMin%2F%2B+Mice.&rft.au=Penny%2C+Hweixian+Leong%3BPrestwood%2C+Tyler+R%3BBhattacharya%2C+Nupur%3BSun%2C+Fionna%3BKenkel%2C+Justin+A%3BDavidson%2C+Matthew+G%3BShen%2C+Lei%3BZuniga%2C+Luis+A%3BSeeley%2C+E+Scott%3BPai%2C+Reetesh%3BChoi%2C+Okmi%3BTolentino%2C+Lorna%3BWang%2C+Jinshan%3BNapoli%2C+Joseph+L%3BEngleman%2C+Edgar+G&rft.aulast=Penny&rft.aufirst=Hweixian&rft.date=2016-11-01&rft.volume=4&rft.issue=11&rft.spage=917&rft.isbn=&rft.btitle=&rft.title=Cancer+immunology+research&rft.issn=2326-6074&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Delayed onset and long-lasting hemidiaphragmatic paralysis and cranial nerve deficit after interscalene nerve block for rotator cuff repair in beach chair position. AN - 1825220126; 27687453 AB - Hemidiaphragmatic paralysis is the most common adverse effect associated with interscalene block. In most cases, it resolves with the resolution of nerve blockade with only an estimated incidence of 0.048% persisting for longer duration. Occasionally, interscalene block is also associated with recurrent laryngeal nerve block and seldom with cranial nerve paresis. We present a case of delayed onset and prolonged hemidiaphragmatic paralysis that was associated with 3 cranial nerve deficits after interscalene nerve block for shoulder surgery performed under general anesthesia in the beach chair position. Etiology is unclear, but most likely multifactorial. JF - Journal of clinical anesthesia AU - Chiaghana, Chukwudi O AU - Awoniyi, Caleb A AD - Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, USA. Electronic address: chuks.chiaghana@gmail.com. ; Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, USA; North Florida/South Georgia Veterans Affairs Medical Center, Gainesville, FL, USA. Electronic address: caleb.awoniyi@va.gov. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 571 EP - 576 VL - 34 KW - Index Medicus KW - Interscalene nerve block KW - Cranial nerve deficit KW - Hemidiaphragmatic paralysis KW - Beach chair position KW - Intraneural injection KW - Local anesthetic toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1825220126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+anesthesia&rft.atitle=Delayed+onset+and+long-lasting+hemidiaphragmatic+paralysis+and+cranial+nerve+deficit+after+interscalene+nerve+block+for+rotator+cuff+repair+in+beach+chair+position.&rft.au=Chiaghana%2C+Chukwudi+O%3BAwoniyi%2C+Caleb+A&rft.aulast=Chiaghana&rft.aufirst=Chukwudi&rft.date=2016-11-01&rft.volume=34&rft.issue=&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+anesthesia&rft.issn=1873-4529&rft_id=info:doi/10.1016%2Fj.jclinane.2016.06.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-30 N1 - Date revised - 2017-02-09 N1 - Last updated - 2017-02-09 DO - http://dx.doi.org/10.1016/j.jclinane.2016.06.026 ER - TY - JOUR T1 - Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions AN - 1827914156; PQ0003723734 AB - Alcohol use is common among people living with human immunodeficiency virus (HIV). In this narrative review, we describe literature regarding alcohol's impact on transmission, care, coinfections, and comorbidities that are common among people living with HIV (PLWH), as well as literature regarding interventions to address alcohol use and its influences among PLWH. This narrative review identifies alcohol use as a risk factor for HIV transmission, as well as a factor impacting the clinical manifestations and management of HIV. Alcohol use appears to have additive and potentially synergistic effects on common HIV-related comorbidities. We find that interventions to modify drinking and improve HIV-related risks and outcomes have had limited success to date, and we recommend research in several areas. Consistent with Office of AIDS Research/National Institutes of Health priorities, we suggest research to better understand how and at what levels alcohol influences comorbid conditions among PLWH, to elucidate the mechanisms by which alcohol use is impacting comorbidities, and to understand whether decreases in alcohol use improve HIV-relevant outcomes. This should include studies regarding whether state-of-the-art medications used to treat common coinfections are safe for PLWH who drink alcohol. We recommend that future research among PLWH include validated self-report measures of alcohol use and/or biological measurements, ideally both. Additionally, subgroup variation in associations should be identified to ensure that the risks of particularly vulnerable populations are understood. This body of research should serve as a foundation for a next generation of intervention studies to address alcohol use from transmission to treatment of HIV. Intervention studies should inform implementation efforts to improve provision of alcohol-related interventions and treatments for PLWH in healthcare settings. By making further progress on understanding how alcohol use affects PLWH in the era of HIV as a chronic condition, this research should inform how we can mitigate transmission, achieve viral suppression, and avoid exacerbating common comorbidities of HIV and alcohol use and make progress toward the 90-90-90 goals for engagement in the HIV treatment cascade. This narrative review finds that alcohol use is associated with HIV acquisition and transmission, lack of viral suppression, common comorbid conditions (e.g., hepatitis C, tuberculosis, cardiovascular disease, frailty/falls, depression, trauma, and other substance use disorders), and ultimately mortality among people living with HIV (PLWH). Associations between alcohol use and HIV-related care and outcomes may disproportionately affect vulnerable subgroups of PLWH. Interventions to address drinking and subsequently improve HIV-related risks and outcomes have been tested with limited success to date. JF - Alcoholism: Clinical and Experimental Research AU - Williams, Emily C AU - Hahn, Judith A AU - Saitz, Richard AU - Bryant, Kendall AU - Lira, Marlene C AU - Samet, Jeffrey H AD - Veterans Health Administration (VA) Health Services Research and Development, Center of Innovation for Veteran-Centered and Value-Driven Care, Seattle, Washington. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 2056 EP - 2072 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 40 IS - 10 SN - 0145-6008, 0145-6008 KW - Immunology Abstracts; Virology & AIDS Abstracts; Toxicology Abstracts KW - Mortality KW - Acquired immune deficiency syndrome KW - Beverages KW - Depression KW - Mycobacterium KW - Retroviridae KW - Infection KW - Drug abuse KW - Disease transmission KW - Trauma KW - Hepatitis C virus KW - Lentivirus KW - Human immunodeficiency virus KW - Risk factors KW - Reviews KW - Alcoholism KW - alcohols KW - Drinking behavior KW - Tuberculosis KW - Cardiovascular diseases KW - Hepatitis C KW - Ethanol KW - V 22360:AIDS and HIV KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827914156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+and+Clinical+Psychology&rft.atitle=Depressive+Symptoms+And+Affective+Reactivity+To+Maternal+Praise+And+Criticism&rft.au=Cuellar%2C+Amy+K%3BJohnson%2C+Sheri+L&rft.aulast=Cuellar&rft.aufirst=Amy&rft.date=2009-11-01&rft.volume=28&rft.issue=9&rft.spage=1173&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+and+Clinical+Psychology&rft.issn=07367236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Mortality; Acquired immune deficiency syndrome; Depression; Beverages; Drug abuse; Infection; Trauma; Disease transmission; Reviews; Risk factors; Alcoholism; alcohols; Drinking behavior; Tuberculosis; Hepatitis C; Cardiovascular diseases; Ethanol; Lentivirus; Hepatitis C virus; Mycobacterium; Human immunodeficiency virus; Retroviridae DO - http://dx.doi.org/10.1111/acer.13204 ER - TY - JOUR T1 - Provider Opinions Regarding the Development of a Stigma-Reduction Intervention Tailored for Providers AN - 1827886858; PQ0003686222 AB - Interventions involving contact with a person who has recovered from mental illness are most effective at reducing stigma. This study sought input from health care providers to inform the design of a contact intervention intended to reduce provider stigma toward persons with serious mental illness. Using a purposive sampling strategy, data were collected from providers at five Veterans Affairs hospitals in the southeastern United States. Seven focus groups were conducted, and 83 health care providers participated. A semistructured interview guide was used to elicit providers' opinions about the target group of a contact intervention for providers, what providers would consider a credible contact, the preferred format for delivery, the usefulness of potentially tailoring the intervention to a specific facility, and how to measure change in clinical behaviors. Focus group data were analyzed using rapid data analysis techniques. Participants uniformly recommended a broad target audience for the stigma-reduction intervention, including all primary care and specialist providers. They suggested that the person providing the "lived experience" for the contact intervention should be either a health care provider or a patient with serious mental illness. Face-to-face presentation was favored, but video presentation was considered more feasible. Participants stated that information about local disparities in care rendered to patients with or without mental illness would convince providers of how stigma may be a contributing factor to these disparities. Multiple training opportunities were favored, while mandatory training was disliked. Standard stigma-reduction interventions with subgroups of the general public (e.g., providers) may need to be modified for optimum subgroup effectiveness. JF - Health Education & Behavior AU - Mittal, Dinesh AU - Corrigan, Patrick AU - Drummond, Karen L AU - Porchia, Sylvia AU - Sullivan, Greer AD - 1 .Central Arkansas Veterans Healthcare System, North Little Rock, AR, USA, Dinesh.Mittal@va.gov Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 577 EP - 583 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 43 IS - 5 SN - 1090-1981, 1090-1981 KW - Physical Education Index KW - intervention KW - mental illness KW - provider stigma KW - schizophrenia KW - stigma KW - Mental illness KW - Health (care) KW - Videotape KW - Analysis KW - Strategy KW - Health (behavior) KW - Patients KW - Standards KW - Hospitals KW - PE 120:Sport: Psychology, Sociology & History UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827886858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+%26+Behavior&rft.atitle=Provider+Opinions+Regarding+the+Development+of+a+Stigma-Reduction+Intervention+Tailored+for+Providers&rft.au=Mittal%2C+Dinesh%3BCorrigan%2C+Patrick%3BDrummond%2C+Karen+L%3BPorchia%2C+Sylvia%3BSullivan%2C+Greer&rft.aulast=Mittal&rft.aufirst=Dinesh&rft.date=2016-10-01&rft.volume=43&rft.issue=5&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=Health+Education+%26+Behavior&rft.issn=10901981&rft_id=info:doi/10.1177%2F1090198115614316 LA - English DB - Physical Education Index N1 - Date revised - 2016-10-01 N1 - Number of references - 27 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Videotape; Health (care); Mental illness; Analysis; Strategy; Health (behavior); Standards; Patients; Hospitals DO - http://dx.doi.org/10.1177/1090198115614316 ER - TY - JOUR T1 - An Engagement Intervention for Young Adults with Serious Mental Health Conditions AN - 1826093038 AB - Young adults with serious mental health conditions (SMHCs) often do not engage continuously with mental health services, and there are few engagement interventions designed for them. This qualitative study presents a blueprint for conceptualizing and developing an engagement intervention designed for young adults with SMHCs. The blueprint includes the following activities: (1) establishing a strong theoretical basis, (2) designing an initial manual based on previous research and practice, (3) systematically examining feedback on the manual from stakeholders, and (4) examining the feasibility, acceptability, and implementation demands of the intervention. Interviews, group discussions, and journaling were utilized to collect information from young adult participant-researchers, intervention facilitators (i.e., recovery role models and clinicians), and additional stakeholders (e.g., clinic staff and administrators) (N=43). Analyses were performed with multiple coders using constant comparative methods. Results revealed critical information to improve the intervention, while also suggesting that the engagement intervention for young adults with SMHCs has promise. JF - Journal of Behavioral Health Services & Research AU - Munson, Michelle R, PhD AU - Cole, Andrea, MSW AU - Jaccard, James, PhD AU - Kranke, Derrick, PhD AU - Farkas, Kathleen, PhD AU - Frese, Fred J, III, PhD AD - New York University Silver School of Social Work, New York, NY, USA ; Veterans Administration, Veterans Emergency Management Evaluation Center (VEMEC), North Hills, CA, USA ; Mandel School of Applied Social Sciences, Case Western Reserve University, Cleveland, OH, USA ; Department of Psychiatry, Northeast Ohio Universities College of Medicine, Rootstown, OH, USA ; New York University Silver School of Social Work, New York, NY, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 542 EP - 563 CY - Gaithersburg PB - Springer Science & Business Media VL - 43 IS - 4 SN - 1094-3412 KW - Public Health And Safety KW - Interventions KW - Young adults KW - Feedback KW - Role models KW - Facilitators KW - Feasibility KW - Mental health services KW - Stakeholders KW - Recovery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826093038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=An+Engagement+Intervention+for+Young+Adults+with+Serious+Mental+Health+Conditions&rft.au=Munson%2C+Michelle+R%2C+PhD%3BCole%2C+Andrea%2C+MSW%3BJaccard%2C+James%2C+PhD%3BKranke%2C+Derrick%2C+PhD%3BFarkas%2C+Kathleen%2C+PhD%3BFrese%2C+Fred+J%2C+III%2C+PhD&rft.aulast=Munson&rft.aufirst=Michelle&rft.date=2016-10-01&rft.volume=43&rft.issue=4&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-014-9424-9 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - National Council for Behavioral Health 2016 N1 - Last updated - 2016-10-06 DO - http://dx.doi.org/10.1007/s11414-014-9424-9 ER - TY - JOUR T1 - Veteran Use of Health Care Systems in Rural States: Comparing VA and Non-VA Health Care Use Among Privately Insured Veterans Under Age 65 AN - 1825276940 AB - Objective To quantify use of VA and non-VA care among working-age veterans with private insurance by linking VA data to private health insurance plan (PHIP) data. Methods Demographics and utilization were compared between dual users of VA and non-VA systems versus single-system users for veterans < 65 living in 2 rural Midwestern states concurrently enrolled in VA health care and a PHIP for ≥ 1 complete federal fiscal year from 2000 to 2010. Chi-square and t-tests were used for univariate analyses. VA reliance was computed as the percentage of visits, admissions and prescriptions in VA. Multinomial logistic regression was used to compare characteristics by dual use versus non-VA only or VA only use. Results Of 16,330 eligible veterans, 54% used both VA and non-VA services, 39% used non-VA only, and 5% used VA only. Compared with single-system use, dual use was associated with older age, priority levels 1-4, service-connected conditions, rural residence, greater years of study eligibility, and enrollment in the PHIP before VA. VA reliance was 33% for outpatient care, 14% for inpatient, and 40% for pharmacy. PHIP data substantially underestimated VA use compared to VA data; 26% who used VA health care had no VA claims in the PHIP dataset. Conclusions Over half of working-age veterans enrolled in VA and private insurance used services in both systems. Care coordination efforts across systems should include veterans of all ages, particularly rural veterans more likely to be dual users, and better methods are needed to identify veterans with private insurance and their private providers. JF - The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association AU - Charlton, Mary E AU - Mengeling, Michelle A AU - Schlichting, Jennifer A AU - Jiang, Lan AU - Turvey, Carolyn AU - Trivedi, Amal N AU - Kizer, Kenneth W AU - West, Alan N AD - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa ; VA Office of Rural Health, Rural Health Resource Center--Central Region, and the Comprehensive Access and Delivery Research and Evaluation (CADRE), Center at the Iowa City VA Healthcare System, Iowa City, Iowa ; VA Center of Innovation in Long-Term Services and Supports for Vulnerable Veterans, Providence VA Healthcare System, Providence, Rhode Island ; Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa; VA Office of Rural Health, Rural Health Resource Center--Central Region, and the Comprehensive Access and Delivery Research and Evaluation (CADRE), Center at the Iowa City VA Healthcare System, Iowa City, Iowa; Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa ; VA Center of Innovation in Long-Term Services and Supports for Vulnerable Veterans, Providence VA Healthcare System, Providence, Rhode Island; Department of Health Services, Policy and Practice and Department of Medicine, Brown University, Providence, Rhode Island ; UC Davis School of Medicine, and Betty Irene Moore School of Nursing, Institute for Population Health Improvement, University of California (UC)-Davis Health System, Sacramento, California ; Research Service, VA Medical Center, White River Junction, Vermont; Office of Rural Health, Veterans Health Administration, Washington, DC ; Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa Y1 - 2016///Fall PY - 2016 DA - Fall 2016 SP - 407 EP - 417 CY - Washington PB - Wiley Subscription Services, Inc. VL - 32 IS - 4 SN - 0890-765X KW - Public Health And Safety KW - Age KW - Health care KW - Health insurance KW - Coordination KW - Veterans KW - Rural communities KW - Reliance KW - Hospitalization KW - Residence KW - Insurance KW - Pharmacy KW - Enrollment KW - Outpatient treatment KW - Prescriptions KW - Delivery Systems KW - Health Care Services KW - Rural Areas KW - Health Care Industry KW - Health Care Utilization KW - Methodology (Data Analysis) KW - Health Insurance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1825276940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.atitle=Veteran+Use+of+Health+Care+Systems+in+Rural+States%3A+Comparing+VA+and+Non-VA+Health+Care+Use+Among+Privately+Insured+Veterans+Under+Age+65&rft.au=Charlton%2C+Mary+E%3BMengeling%2C+Michelle+A%3BSchlichting%2C+Jennifer+A%3BJiang%2C+Lan%3BTurvey%2C+Carolyn%3BTrivedi%2C+Amal+N%3BKizer%2C+Kenneth+W%3BWest%2C+Alan+N&rft.aulast=Charlton&rft.aufirst=Mary&rft.date=2016-10-01&rft.volume=32&rft.issue=4&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fjrh.12206 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); PAIS Index N1 - Copyright - © 2016 National Rural Health Association N1 - Last updated - 2016-10-03 DO - http://dx.doi.org/10.1111/jrh.12206 ER - TY - JOUR T1 - Insured Veterans' Use of VA and Non-VA Health Care in a Rural State AN - 1825276864 AB - Purpose To understand how working-age VA-enrolled veterans with commercial insurance use both VA and non-VA outpatient care, and how rural residence affects dual use, for common diagnoses and procedures. Methods We analyzed VA and non-VA outpatient treatment records for any months during 2005-2010 that New Hampshire veterans ages <65 were simultaneously enrolled in VA health care and commercial insurance (per NH's mandatory claims database). Controlling for covariates, we used analysis of variance to compare urban and rural VA users, non-VA users, and dual users on travel burden, diagnosis counts, duration in outpatient care, and visit frequencies, and logistic regressions to assess whether rural veterans were as likely to be seen for common conditions and procedures. Findings More than half of patients were non-VA users and another third were dual users; rural residents were slightly more likely than urban residents to be dual users. For nearly any common diagnosis or procedure, dual users were more likely to have it at some time during treatment than other patients in either VA or non-VA care, but they seldom had it listed in both care systems. Dual users also were seen most often overall, although within either care system they were seen less often than other patients, particularly if they were rural residents living far from care. Rural residence reduced chances of treatment for a wide variety of conditions, though it also was associated with more musculoskeletal and connective tissue diagnoses. It also reduced chances that patients had some diagnostic and treatment procedures but increased the odds of others that may require fewer visits. Conclusions Dual users living in rural areas may have less continuity in their health care. Ensuring that rural dual users are identified in primary care should improve access and care coordination. JF - The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association AU - West, Alan N AU - Charlton, Mary E AD - Research Service, VA Medical Center, White River Junction, Vermont; Office of Rural Health, Veterans Health Administration, Washington, DC ; Iowa City VA Health Care System, Comprehensive Access and Delivery Research and Evaluation (CADRE) Center, Iowa City, Iowa; Department of Epidemiology, The University of Iowa College of Public Health, Iowa City, Iowa ; Research Service, VA Medical Center, White River Junction, Vermont; Office of Rural Health, Veterans Health Administration, Washington, DC Y1 - 2016///Fall PY - 2016 DA - Fall 2016 SP - 387 EP - 396 CY - Washington PB - Wiley Subscription Services, Inc. VL - 32 IS - 4 SN - 0890-765X KW - Public Health And Safety KW - Rural areas KW - Health insurance KW - Databases KW - Coordination KW - Primary health care KW - Veterans KW - Insurance KW - Rural communities KW - Residence KW - Diagnosis KW - Outpatient treatment KW - Health Care Services KW - Rural Areas KW - Urban Population KW - Patients KW - Residents KW - Travel KW - Treatment KW - Variance (Statistics) KW - Health Insurance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1825276864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.atitle=Insured+Veterans%27+Use+of+VA+and+Non-VA+Health+Care+in+a+Rural+State&rft.au=West%2C+Alan+N%3BCharlton%2C+Mary+E&rft.aulast=West&rft.aufirst=Alan&rft.date=2016-10-01&rft.volume=32&rft.issue=4&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fjrh.12196 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); PAIS Index N1 - Copyright - © 2016 National Rural Health Association N1 - Last updated - 2016-10-03 DO - http://dx.doi.org/10.1111/jrh.12196 ER - TY - JOUR T1 - Alcohol intake alters immune responses and promotes CNS viral persistence in mice. AN - 1808604639; 27269869 AB - Chronic hepatitis C virus (HCV) infection leads to progressive liver disease and is associated with a variety of extrahepatic effects, including central nervous system (CNS) damage and neuropsychiatric impairments. Alcohol abuse can exacerbate these adverse effects on brain and behavior, but the molecular mechanisms are not well understood. This study investigated the role of alcohol in regulating viral persistence and CNS immunopathology in mice infected with lymphocytic choriomeningitis virus (LCMV), a model for HCV infections in humans. Female and male BALB/c mice (n=94) were exposed to alcohol (ethanol; EtOH) and water (or water only) using a two-bottle choice paradigm, followed one week later by infection with either LCMV clone 13 (causes chronic infection similar to chronic HCV), LCMV Armstrong (causes acute infection), or vehicle. Mice were monitored for 60days post-infection and continued to receive 24-h access to EtOH and water. Animals infected with LCMV clone 13 drank more EtOH, as compared to those with an acute or no viral infection. Six weeks after infection with LCMV clone 13, mice with EtOH exposure evidenced higher serum viral titers, as compared to mice without EtOH exposure. EtOH intake was also associated with reductions in virus-specific CD8(+) T cell frequencies (particularly CD11a(hi) subsets) and evidence of persistent CNS viremia in chronically infected mice. These findings support the hypothesis that EtOH use and chronic viral infection can result in combined toxic effects accelerating CNS damage and neuropsychiatric dysfunction and suggest that examining the role of EtOH in regulating viral persistence and CNS immunopathology in mice infected with LCMV can lead to a more comprehensive understanding of comorbid alcohol use disorder and chronic viral infection. Published by Elsevier B.V. JF - Behavioural brain research AU - Loftis, Jennifer M AU - Taylor, Jonathan AU - Raué, Hans-Peter AU - Slifka, Mark K AU - Huang, Elaine AD - Research & Development Service, Veterans Affairs Portland Health Care System, 3710 SW U.S. Veterans Hospital Rd., Portland, OR 97239, USA; Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA. Electronic address: jennifer.loftis2@va.gov. ; Research & Development Service, Veterans Affairs Portland Health Care System, 3710 SW U.S. Veterans Hospital Rd., Portland, OR 97239, USA; Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA. Electronic address: taylorjo@ohsu.edu. ; Division of Neuroscience, Department of Molecular Microbiology and Immunology, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA. Electronic address: raueh@ohsu.edu. ; Division of Neuroscience, Department of Molecular Microbiology and Immunology, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA. Electronic address: slifkam@ohsu.edu. ; Research & Development Service, Veterans Affairs Portland Health Care System, 3710 SW U.S. Veterans Hospital Rd., Portland, OR 97239, USA; Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA. Electronic address: huange@ohsu.edu. Y1 - 2016/10/01/ PY - 2016 DA - 2016 Oct 01 SP - 1 EP - 8 VL - 312 KW - Index Medicus KW - Lymphocytic choriomeningitis virus KW - Blood brain barrier KW - T-cells KW - Hepatitis C virus KW - Neurotoxicity KW - Ethanol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808604639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+brain+research&rft.atitle=Alcohol+intake+alters+immune+responses+and+promotes+CNS+viral+persistence+in+mice.&rft.au=Loftis%2C+Jennifer+M%3BTaylor%2C+Jonathan%3BRau%C3%A9%2C+Hans-Peter%3BSlifka%2C+Mark+K%3BHuang%2C+Elaine&rft.aulast=Loftis&rft.aufirst=Jennifer&rft.date=2016-10-01&rft.volume=312&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Behavioural+brain+research&rft.issn=1872-7549&rft_id=info:doi/10.1016%2Fj.bbr.2016.06.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bbr.2016.06.006 ER - TY - JOUR T1 - Intervention Efficacy in Engaging Black and White Veterans with Post-traumatic Stress Disorder into Treatment AN - 1807616170 AB - This study examined racial differences among Black and White Veterans who screened positive for post-traumatic stress disorder (PTSD) but were not in PTSD treatment and were participating in an intervention trial. Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) Veterans with PTSD but not yet engaged in treatment were recruited and randomly assigned to control or intervention conditions. Intervention participants received a cognitive-behavioral engagement intervention by phone. All participants received follow-up calls to assess symptoms and utilization of treatment. Black and White participants were compared to assess differences in treatment utilization. Intervention session notes were analyzed qualitatively for explanatory themes. Participants of both races who received the intervention had higher PTSD treatment initiation than their respective control groups (Blacks: 85% vs. 58% and Whites: 53% vs. 45%, respectively). However, Blacks completed fewer PTSD treatment sessions compared to Whites overall (M = 2.06 [SD = 2.3] vs. M = 3.77 [SD = 9.9]; p < .05). Within the intervention condition, Blacks were significantly more likely to initiate treatment (odds ratio = 2.3, p < .04), and had a greater reduction in PTSD symptom compared to Whites (PTSD Checklist - Military Version [PCL] scores: 12.75 vs. 9.68). Based on qualitative analysis of intervention session notes, themes emerged that may suggest cultural differences involving social connection, attitudes towards treatment, and the desire to appear "okay." Blacks had a higher initiation rate and greater reduction in PTSD severity but completed fewer treatment sessions than Whites. These are promising results with respect to other studies which demonstrate that Black Veterans are less likely to seek treatment for PTSD. JF - Social Work in Public Health AU - Stecker, Tracy AU - Adams, Leslie AU - Carpenter-Song, Elizabeth AU - Nicholson, Joanne AU - Streltzov, Nicholas AU - Xie, Haiyi AD - Psychiatric Research Center, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA; VA Health Services Research and Development, White River Junction Veterans Administration, White River Junction, Vermont, USA ; Psychiatric Research Center, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA ; Psychiatric Research Center, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA; VA Health Services Research and Development, White River Junction Veterans Administration, White River Junction, Vermont, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 481 EP - 489 CY - Abingdon PB - Taylor & Francis Ltd. VL - 31 IS - 6 SN - 1937-1918 KW - Social Services And Welfare KW - Treatment seeking KW - treatment engagement KW - OEF/OIF Veterans KW - PTSD KW - health disparities KW - Freedom KW - Armed Forces KW - Black White Differences KW - Racial Differences KW - Social Attitudes KW - Intervention KW - Crosscultural Differences KW - Posttraumatic Stress Disorder KW - Qualitative Methods KW - Symptoms KW - Trauma KW - Veterans KW - Iraq KW - 6140:illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1807616170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Public+Health&rft.atitle=Intervention+Efficacy+in+Engaging+Black+and+White+Veterans+with+Post-traumatic+Stress+Disorder+into+Treatment&rft.au=Stecker%2C+Tracy%3BAdams%2C+Leslie%3BCarpenter-Song%2C+Elizabeth%3BNicholson%2C+Joanne%3BStreltzov%2C+Nicholas%3BXie%2C+Haiyi&rft.aulast=Stecker&rft.aufirst=Tracy&rft.date=2016-10-01&rft.volume=31&rft.issue=6&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Public+Health&rft.issn=19371918&rft_id=info:doi/10.1080%2F19371918.2016.1160340 LA - English DB - Social Services Abstracts N1 - Copyright - © 2016 Taylor & Francis Group, LLC N1 - Last updated - 2016-10-25 N1 - SubjectsTermNotLitGenreText - Iraq DO - http://dx.doi.org/10.1080/19371918.2016.1160340 ER - TY - JOUR T1 - The Relation of Arm Exercise Peak Heart Rate to Stress Test Results and Outcome AN - 1827882325; PQ0003666796 AB - Purpose: Arm exercise is an alternative to pharmacologic stress testing for >50% of patients unable to perform treadmill exercise, but no data exist regarding the effect of attained peak arm exercise heart rate on test sensitivity. Thus, the purpose of this investigation was to characterize the relationship of peak arm exercise heart rate responses to abnormal stress test findings, coronary revascularization, and mortality in patients unable to perform leg exercise. Methods: From 1997 until 2002, arm cycle ergometer stress tests were performed in 443 consecutive veterans age 64.1 yr (11.0 yr) (mean (SD)), of whom 253 also underwent myocardial perfusion imaging (MPI). Patients were categorized by frequency distributions of quartiles of percentage age-predicted peak heart rate (APPHR), heart rate reserve (HRR), and peak heart rate-systolic blood pressure product (PRPP). Exercise-induced ST-segment depression, abnormal MPI findings, coronary revascularization, and 12.0-yr (1.3 yr) Kaplan-Meier all-cause and cardiovascular mortality plots were then characterized by quartiles of APPHR, HRR, and PRPP. Results: A reduced frequency of abnormal arm exercise ECG results was associated only with the lowest quartile of APPHR ([< or =]69%) and HRR ([< or =]43%), whereas higher frequency of abnormal MPI findings exhibited an inverse relationship trend with lower APPHR (P= 0.10) and HRR (P= 0.12). There was a strong inverse association of APPHR, HRR, and PRPP with all-cause (all P[< or =] 0.01) and cardiovascular (P< 0.05) mortality. The frequency of coronary revascularization was unrelated to APPHR or HRR. Conclusions: Arm exercise ECG stress test sensitivity is only reduced at [< or =]69% APPHR or [< or =]43% HRR, whereas arm exercise MPI sensitivity and referral for coronary revascularization after arm exercise stress testing are not adversely affected by even a severely blunted peak heart rate. However, both all-cause mortality and cardiovascular mortality are strongly and inversely related to APPHR and HRR. JF - Medicine & Science in Sports & Exercise AU - Hong, Xian AU - Weijian, Liu AU - Cynthia, Marshall AU - Pooja, Chandiramani AU - Emily, Bainter AU - Martin, Wade H AD - Division of Cardiology 111A/JC, St. Louis Veterans Administration Healthcare System, 915 North Grand, St. Louis, MO 63106, Wade.Martin@va.gov Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1648 EP - 1654 PB - Lippincott Williams & Wilkins, 530 Walnut Street Philadelphia PA 19106-3621 United States VL - 48 IS - 9 SN - 0195-9131, 0195-9131 KW - Physical Education Index KW - AGE-PREDICTED PEAK HEART RATE KW - CORONARY REVASCULARIZATION KW - HEART RATE RESERVE KW - MORTALITY KW - MYOCARDIAL PERFUSION IMAGING KW - STRESS TEST SENSITIVITY KW - Stress tests KW - Death KW - Heart rate (exercise effects) KW - Heart rate KW - Motor performance tests KW - Sport science KW - Cardiorespiratory KW - Patients KW - Electrocardiology KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827882325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicine+%26+Science+in+Sports+%26+Exercise&rft.atitle=The+Relation+of+Arm+Exercise+Peak+Heart+Rate+to+Stress+Test+Results+and+Outcome&rft.au=Hong%2C+Xian%3BWeijian%2C+Liu%3BCynthia%2C+Marshall%3BPooja%2C+Chandiramani%3BEmily%2C+Bainter%3BMartin%2C+Wade+H&rft.aulast=Hong&rft.aufirst=Xian&rft.date=2016-09-01&rft.volume=48&rft.issue=9&rft.spage=1648&rft.isbn=&rft.btitle=&rft.title=Medicine+%26+Science+in+Sports+%26+Exercise&rft.issn=01959131&rft_id=info:doi/10.1249%2FMSS.0000000000000971 LA - English DB - Physical Education Index N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Death; Stress tests; Heart rate (exercise effects); Heart rate; Sport science; Motor performance tests; Patients; Cardiorespiratory; Electrocardiology DO - http://dx.doi.org/10.1249/MSS.0000000000000971 ER - TY - JOUR T1 - Evaluation of safety climate and employee injury rates in healthcare AN - 1815709931; PQ0003596861 AB - ObjectivesSafety climates that support safety-related behaviour are associated with fewer work-related injuries, and prior research in industry suggests that safety knowledge and motivation are strongly related to safety performance behaviours; this relationship is not well studied in healthcare settings.MethodsWe performed analyses of survey results from a Veterans Health Administration (VHA) Safety Barometer employee perception survey, conducted among VHA employees in 2012. The employee perception survey assessed 6 safety programme categories, including management participation, supervisor participation, employee participation, safety support activities, safety support climate and organisational climate. We examined the relationship between safety climate from the survey results on VHA employee injury and illness rates.ResultsAmong VHA facilities in the VA New England Healthcare System, work-related injury rate was significantly and inversely related to overall employee perception of safety climate, and all 6 safety programme categories, including employee perception of employee participation, management participation, organisational climate, supervisor participation, safety support activities and safety support climate.ConclusionsPositive employee perceptions of safety climate in VHA facilities are associated with lower work-related injury and illness rates. Employee perception of employee participation, management participation, organisational climate, supervisor participation, safety support activities and safety support climate were all associated with lower work-related injury rates. Future implications include fostering a robust safety climate for patients and healthcare workers to reduce healthcare worker injuries. JF - Occupational and Environmental Medicine AU - Cook, Jacqueline M AU - Slade, Martin D AU - Cantley, Linda F AU - Sakr, Carine J AD - Veterans Administration Connecticut Healthcare System, Department of Veterans Affairs, Veterans Health Administration Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 595 EP - 599 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - 9 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts KW - Injuries KW - Health care KW - Perception KW - Safety KW - Climate KW - Barometers KW - Medical personnel KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815709931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Evaluation+of+safety+climate+and+employee+injury+rates+in+healthcare&rft.au=Cook%2C+Jacqueline+M%3BSlade%2C+Martin+D%3BCantley%2C+Linda+F%3BSakr%2C+Carine+J&rft.aulast=Cook&rft.aufirst=Jacqueline&rft.date=2016-09-01&rft.volume=73&rft.issue=9&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2015-103218 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Health care; Injuries; Perception; Climate; Safety; Barometers; Medical personnel DO - http://dx.doi.org/10.1136/oemed-2015-103218 ER - TY - JOUR T1 - At-Home Versus In-Clinic INR Monitoring: A Cost-Utility Analysis from The Home INR Study (THINRS) AN - 1815696785; PQ0003592073 AB - Effective management of patients using warfarin is resource-intensive, requiring frequent in-clinic testing of the international normalized ratio (INR). Patient self-testing (PST) using portable at-home INR monitoring devices has emerged as a convenient alternative. As revealed by The Home INR Study (THINRS), event rates for PST were not significantly different from those for in-clinic high-quality anticoagulation management (HQACM), and a cumulative gain in quality of life was observed for patients undergoing PST. To perform a cost-utility analysis of weekly PST versus monthly HQACM and to examine the sensitivity of these results to testing frequency. In this study, 2922 patients taking warfarin for atrial fibrillation or mechanical heart valve, and who demonstrated PST competence, were randomized to either weekly PST (n=1465) or monthly in-clinic testing (n=1457). In a sub-study, 234 additional patients were randomized to PST once every 4 weeks (n=116) or PST twice weekly (n=118). The endpoints were quality of life (measured by the Health Utilities Index), health care utilization, and costs over 2 years of follow-up. PST and HQACM participants were similar with regard to gender, age, and CHADS sub(2) score. The total cost per patient over 2 years of follow-up was $32,484 for HQACM and $33,460 for weekly PST, representing a difference of $976. The incremental cost per quality-adjusted life year gained with PST once weekly was $5566 (95 % CI, -$11,490 to $25,142). The incremental cost-effectiveness ratio (ICER) was sensitive to testing frequency: weekly PST dominated PST twice weekly and once every 4 weeks. Compared to HQACM, weekly PST was associated with statistically significant and clinically meaningful improvements in quality of life. The ICER for weekly PST versus HQACM was well within accepted standards for cost-effectiveness, and was preferred over more or less frequent PST. These results were robust to sensitivity analyses of key assumptions. Weekly PST is a cost-effective alternative to monthly HQACM and a preferred testing frequency compared to twice weekly or monthly PST. JF - Journal of General Internal Medicine AU - Phibbs, Ciaran S AU - Love, Sean R AU - Jacobson, Alan K AU - Edson, Robert AU - Su, Pon AU - Uyeda, Lauren AU - Matchar, David B AD - Health Economics Resource Center, VA Palo Alto Health Care System, Palo Alto, CA, USA, CiaranPhibbs@va.gov Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1061 EP - 1067 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 31 IS - 9 SN - 0884-8734, 0884-8734 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Age KW - Fibrillation KW - Statistical analysis KW - Warfarin KW - Quality of life KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815696785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+General+Internal+Medicine&rft.atitle=At-Home+Versus+In-Clinic+INR+Monitoring%3A+A+Cost-Utility+Analysis+from+The+Home+INR+Study+%28THINRS%29&rft.au=Phibbs%2C+Ciaran+S%3BLove%2C+Sean+R%3BJacobson%2C+Alan+K%3BEdson%2C+Robert%3BSu%2C+Pon%3BUyeda%2C+Lauren%3BMatchar%2C+David+B&rft.aulast=Phibbs&rft.aufirst=Ciaran&rft.date=2016-09-01&rft.volume=31&rft.issue=9&rft.spage=1061&rft.isbn=&rft.btitle=&rft.title=Journal+of+General+Internal+Medicine&rft.issn=08848734&rft_id=info:doi/10.1007%2Fs11606-016-3700-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 29 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Heart; Age; Fibrillation; Statistical analysis; Warfarin; Quality of life DO - http://dx.doi.org/10.1007/s11606-016-3700-8 ER - TY - JOUR T1 - Clearance of apoptotic neutrophils and resolution of inflammation. AN - 1814658308; 27558346 AB - The engulfment of apoptotic cells by phagocytes, a process referred to as efferocytosis, is essential for maintenance of normal tissue homeostasis and a prerequisite for the resolution of inflammation. Neutrophils are the predominant circulating white blood cell in humans, and contain an arsenal of toxic substances that kill and degrade microbes. Neutrophils are short-lived and spontaneously die by apoptosis. This review will highlight how the engulfment of apoptotic neutrophils by human phagocytes occurs, how heterogeneity of phagocyte populations influences efferocytosis signaling, and downstream consequences of efferocytosis. The efferocytosis of apoptotic neutrophils by macrophages promotes anti-inflammatory signaling, prevents neutrophil lysis, and dampens immune responses. Given the immunomodulatory properties of efferocytosis, understanding pathways that regulate and enhance efferocytosis could be harnessed to combat infection and chronic inflammatory conditions. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. JF - Immunological reviews AU - Greenlee-Wacker, Mallary C AD - Inflammation Program, Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Veterans Administration Medical Center, Iowa City, IA, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 357 EP - 370 VL - 273 IS - 1 KW - Index Medicus KW - inflammation KW - apoptosis KW - infection KW - neutrophil KW - efferocytosis KW - macrophages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814658308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunological+reviews&rft.atitle=Clearance+of+apoptotic+neutrophils+and+resolution+of+inflammation.&rft.au=Greenlee-Wacker%2C+Mallary+C&rft.aulast=Greenlee-Wacker&rft.aufirst=Mallary&rft.date=2016-09-01&rft.volume=273&rft.issue=1&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Immunological+reviews&rft.issn=1600-065X&rft_id=info:doi/10.1111%2Fimr.12453 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/imr.12453 ER - TY - JOUR T1 - The Utility of Exercise Testing in Patients with Lung Cancer. AN - 1814648042; 27156441 AB - The harm associated with lung cancer treatment include perioperative morbidity and mortality and therapy-induced toxicities in various organs, including the heart and lungs. Optimal treatment therefore entails a need for risk assessment to weigh the probabilities of benefits versus harm. Exercise testing offers an opportunity to evaluate a patient's physical fitness/exercise capacity objectively. In lung cancer, it is most often used to risk-stratify patients undergoing evaluation for lung cancer resection. In recent years, its use outside this context has been described, including in nonsurgical candidates and lung cancer survivors. In this article we review the physiology of exercise testing and lung cancer. Then, we assess the utility of exercise testing in patients with lung cancer in four contexts (preoperative evaluation for lung cancer resection, after lung cancer resection, lung cancer prognosis, and assessment of efficiency of exercise training programs) after systematically identifying original studies involving the most common forms of exercise tests in this patient population: laboratory cardiopulmonary exercise testing and simple field testing with the 6-minute walk test, shuttle walk test, and/or stair-climbing test. Lastly, we propose a conceptual framework for risk assessment of patients with lung cancer who are being considered for therapy and identify areas for further studies in this patient population. Copyright © 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved. JF - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer AU - Ha, Duc AU - Mazzone, Peter J AU - Ries, Andrew L AU - Malhotra, Atul AU - Fuster, Mark AD - Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California. Electronic address: d5ha@ucsd.edu. ; Respiratory Institute, Cleveland Clinic, Cleveland, Ohio. ; Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California. ; Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California; Pulmonary and Critical Care Medicine Section, Veterans Administration San Diego Healthcare System, San Diego, California. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1397 EP - 1410 VL - 11 IS - 9 KW - Index Medicus KW - Stair-climbing test KW - Shuttle walk test KW - Exercise testing KW - Cardiopulmonary exercise testing KW - Six-minute walk test KW - Lung cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814648042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.atitle=The+Utility+of+Exercise+Testing+in+Patients+with+Lung+Cancer.&rft.au=Ha%2C+Duc%3BMazzone%2C+Peter+J%3BRies%2C+Andrew+L%3BMalhotra%2C+Atul%3BFuster%2C+Mark&rft.aulast=Ha&rft.aufirst=Duc&rft.date=2016-09-01&rft.volume=11&rft.issue=9&rft.spage=1397&rft.isbn=&rft.btitle=&rft.title=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.issn=1556-1380&rft_id=info:doi/10.1016%2Fj.jtho.2016.04.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jtho.2016.04.021 ER - TY - JOUR T1 - "I'm Coming Home, Tell the World I'm Coming Home". The Long Homecoming and Mental Health Treatment of Iraq and Afghanistan War Veterans AN - 1811252332 AB - This study explored the journey of American armed forces personnel from their decision to join the service, through their service in an active military conflict and how these factors may be associated with potential resistance for mental healthcare. The data came from qualitative interviews with 46 OIF/OEF/OND active-duty military, reservists, and discharged veterans of the average age of 25 years, who presented for a new episode of mental health treatment to a large Veterans Affairs Hospital (VAH) in Northeastern United States in 2011-2012. Qualitative analysis of veterans' perceptions revealed several major themes describing how a mental health diagnosis would negatively impact both their sense of identity and pragmatic career-building goals: enlisting as a career-building avenue, 'noble superhero' identity, escaping from hardship, and mental illness as a career-killer. Findings suggest that factors making young veterans resist mental healthcare may be reduced by partnering VAH psychiatrists with career counselors, and by enhancing military leadership's awareness and understanding about how to support soldiers with emotional and mental health needs, with a goal to eliminating stigma. JF - Psychiatric Quarterly AU - Rozanova, Julia AU - Noulas, Paraskevi AU - Smart, Kathleen AU - Roy, Alicia AU - Southwick, Steven M AU - Davidson, Larry AU - Harpaz-rotem, Ilan AD - Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA ; VA Connecticut Healthcare System, West Haven, CT, USA ; VA Connecticut Healthcare System, West Haven, CT, USA; United States Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, West Haven, CT, USA ; United States Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, West Haven, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA ; United States Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, West Haven, CT, USA; Yale Program for Recovery and Community Health, New Haven, CT, USA ; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA Y1 - 2016/09// PY - 2016 DA - Sep 2016 SP - 427 EP - 443 CY - New York PB - Springer Science & Business Media VL - 87 IS - 3 SN - 0033-2720 KW - Medical Sciences--Psychiatry And Neurology KW - Young US veterans KW - Mental healthcare resistance KW - Qualitative interviews KW - Sense of identity KW - Pragmatic career-building goals KW - Leadership KW - Soldiers KW - Discharged KW - Veterans KW - Military forces KW - Personnel KW - Stigmatization KW - Resistance KW - Health needs KW - Psychiatrists KW - Mental health services KW - Military personnel KW - Qualitative analysis KW - Diagnosis KW - Identity KW - Mental illness KW - United States--US KW - Afghanistan KW - Iraq UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811252332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+Quarterly&rft.atitle=%22I%27m+Coming+Home%2C+Tell+the+World+I%27m+Coming+Home%22.+The+Long+Homecoming+and+Mental+Health+Treatment+of+Iraq+and+Afghanistan+War+Veterans&rft.au=Rozanova%2C+Julia%3BNoulas%2C+Paraskevi%3BSmart%2C+Kathleen%3BRoy%2C+Alicia%3BSouthwick%2C+Steven+M%3BDavidson%2C+Larry%3BHarpaz-rotem%2C+Ilan&rft.aulast=Rozanova&rft.aufirst=Julia&rft.date=2016-09-01&rft.volume=87&rft.issue=3&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Psychiatric+Quarterly&rft.issn=00332720&rft_id=info:doi/10.1007%2Fs11126-015-9398-7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Springer Science+Business Media New York 2016 N1 - Last updated - 2016-08-24 N1 - SubjectsTermNotLitGenreText - Afghanistan; United States--US; Iraq DO - http://dx.doi.org/10.1007/s11126-015-9398-7 ER - TY - JOUR T1 - Practical Disadvantage, Socioeconomic Status, and Psychological Well-Being Within Families of Children with Severe Emotional Disturbance AN - 1810994965 AB - Although socioeconomic status (SES) has been associated with a myriad of physical and psychological health indicators, it is arguably one of the most elusive constructs in the psychological literature. Most researchers agree that SES is complex and multidimensional; however, the majority of empirical studies that focus on SES do not measure (or attempt to measure) multiple components of the construct, instead focusing on one or two indicators of SES, most commonly household income and/or levels of education. This paper explores relationships among indicators of SES, disadvantage, and psychological well-being in two independent samples of families with children with severe emotional disturbances. In addition to utilizing two common SES indicators (parental education and income), we incorporated measures reflecting resource-related challenges of living, such as adequate food and housing. Based on analyses, we argue that such variables may better capture the challenges experienced by many families than traditional SES indicators. Findings also suggest that income and education relate to different aspects of family well-being, and solely using one or both of these variables may mask relevant relationships. Moreover, assessing practical, day-to-day challenges may permit a more nuanced picture of the relationships between factors associated with SES and indicators of well-being and adjustment. JF - Journal of Child and Family Studies AU - Munsell, Eylin Palamaro AU - Kilmer, Ryan P AU - Vishnevsky, Tanya AU - Cook, James R AU - Markley, Lauren M AD - University of North Carolina Charlotte, Charlotte, NC, USA; Arizona State University Colleges at Lake Havasu City, Lake Havasu City, AZ, USA ; University of North Carolina Charlotte, Charlotte, NC, USA ; University of North Carolina Charlotte, Charlotte, NC, USA; Providence Behavioral Health Associates, Providence, RI, USA ; El Paso Veterans Administration Healthcare System, El Paso, TX, USA ; University of North Carolina Charlotte, Charlotte, NC, USA; Arizona State University Colleges at Lake Havasu City, Lake Havasu City, AZ, USA Y1 - 2016/09// PY - 2016 DA - Sep 2016 SP - 2832 EP - 2842 CY - New York PB - Springer Science & Business Media VL - 25 IS - 9 SN - 1062-1024 KW - Psychology KW - Socioeconomic status KW - Family wellbeing KW - Poverty KW - Education KW - Income KW - Emotional disturbance KW - Healthy food KW - Health status KW - Emotionally disturbed children KW - Health indicators KW - Mental health KW - Psychological wellbeing KW - Housing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1810994965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Effect+of+Rotator+Cuff+Muscle+Imbalance+on+Forceful+Internal+Impingement+and+Peel-Back+of+the+Superior+Labrum.+A+Cadaveric+Study&rft.au=Mihata%2C+Teruhisa%3BGates%2C+Jeffrey%3BMcGarry%2C+Michelle+H%3BLee%2C+Jason%3BKinoshita%2C+Mitsuo%3BLee%2C+Thay+Q&rft.aulast=Mihata&rft.aufirst=Teruhisa&rft.date=2009-11-01&rft.volume=37&rft.issue=11&rft.spage=2222&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F0363546509337450 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Springer Science+Business Media New York 2016 N1 - Last updated - 2016-10-12 DO - http://dx.doi.org/10.1007/s10826-016-0449-y ER - TY - JOUR T1 - A Lens Model Approach to the Communication of Pain AN - 1808612966; PQ0003266872 AB - Two studies examined the expression and detection of suppressed, genuine, and exaggerated pain. In Study 1, videotaped participants underwent an acute laboratory pain stressor and completed pain ratings. In Study 2, the lens model examined the cues encoders displayed while in pain (facial expressions of pain and viewers' global impressions), the cues decoders used to infer pain in the videotaped encoders, and decoders' accuracy in making judgments of pain. Results revealed expression differences between the suppressed, genuine, and exaggerated pain such that exaggerated expressions contained more tightened facial expressions while genuine expressions of pain contained more open facial expressions of pain. Decoders were accurate at detecting pain only in the exaggerated pain expressions. These results highlight the need for improving providers' accuracy in detecting pain intensity for suppressed, genuine, and exaggerated pain displays. Trainings should focus on teaching providers that patients who appear more agitated and less composed may be suppressing pain, while patients who appear more tense and determined may be exaggerating pain. Finally, patients who seem to not be in that much pain because they are not showing tightened facial expressions may actually be experiencing higher intensities of genuine pain. JF - Health Communication AU - Ruben, Mollie A AU - Hall, Judith A AD - Center for Healthcare Organization and Implementation Research, U.S. Department of Veterans Affairs Y1 - 2016/08/02/ PY - 2016 DA - 2016 Aug 02 SP - 934 EP - 945 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 31 IS - 8 SN - 1041-0236, 1041-0236 KW - Environment Abstracts KW - Communications KW - Training KW - Pain KW - ENA 04:Environmental Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808612966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Australasian+Professional+Society+on+Alcohol+and+other+Drugs+%28APSAD+2009%29&rft.atitle=Odds+ratios+of+externalizing+and+internalizing+disorders%3A+An+approach+to+service+design+within+and+across+cultures&rft.au=Westermeyer%2C+Joe&rft.aulast=Westermeyer&rft.aufirst=Joe&rft.date=2009-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Australasian+Professional+Society+on+Alcohol+and+other+Drugs+%28APSAD+2009%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Communications; Training; Pain DO - http://dx.doi.org/10.1080/10410236.2015.1020261 ER - TY - JOUR T1 - Through Their Eyes AN - 1851151708 AB - In this methodological article, we examine participatory methods in depth to demonstrate how these methods can be adopted for quality improvement (QI) projects in health care. We draw on existing literature and our QI initiatives in the Department of Veterans Affairs to discuss the application of photovoice and guided tours in QI efforts. We highlight lessons learned and several benefits of using participatory methods in this area. Using participatory methods, evaluators can engage patients, providers, and other stakeholders as partners to enhance care. Participant involvement helps yield actionable data that can be translated into improved care practices. Use of these methods also helps generate key insights to inform improvements that truly resonate with stakeholders. Using participatory methods is a valuable strategy to harness participant engagement and drive improvements that address individual needs. In applying these innovative methodologies, evaluators can transcend traditional approaches to uniquely support evaluations and improvements in health care. JF - Qualitative Health Research AU - Balbale, Salva N AU - Locatelli, Sara M AU - LaVela, Sherri L AD - U.S. Department of Veterans Affairs, Hines, Illinois, USA ; U.S. Department of Veterans Affairs, Hines, Illinois, USA Y1 - 2016/08// PY - 2016 DA - Aug 2016 SP - 1382 EP - 1392 CY - Thousand Oaks PB - SAGE PUBLICATIONS, INC. VL - 26 IS - 10 SN - 1049-7323 KW - Medical Sciences KW - health care KW - guided tours KW - participatory action research (PAR) KW - photography KW - photovoice KW - qualitative KW - United States KW - Quality management KW - Veterans KW - Stakeholders KW - Photography KW - Health care KW - Health initiatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1851151708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Qualitative+Health+Research&rft.atitle=Through+Their+Eyes&rft.au=Balbale%2C+Salva+N%3BLocatelli%2C+Sara+M%3BLaVela%2C+Sherri+L&rft.aulast=Balbale&rft.aufirst=Salva&rft.date=2016-08-01&rft.volume=26&rft.issue=10&rft.spage=1382&rft.isbn=&rft.btitle=&rft.title=Qualitative+Health+Research&rft.issn=10497323&rft_id=info:doi/10.1177%2F1049732315618386 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2015 N1 - Last updated - 2017-01-06 DO - http://dx.doi.org/10.1177/1049732315618386 ER - TY - JOUR T1 - Somatic mutations in histiocytic sarcoma identified by next generation sequencing AN - 1815709373; PQ0003589986 AB - Histiocytic sarcoma is a rare malignant neoplasm of presumed hematopoietic origin showing morphologic and immunophenotypic evidence of histiocytic differentiation. Somatic mutation importance in the pathogenesis or disease progression of histiocytic sarcoma was largely unknown. To identify somatic mutations in histiocytic sarcoma, we studied 5 histiocytic sarcomas [3 female and 2 male patients; mean age 54.8 (20-72), anatomic sites include lymph node, uterus, and pleura] and matched normal tissues from each patient as germ line controls. Somatic mutations in 50 "Hotspot" oncogenes and tumor suppressor genes were examined using next generation sequencing. Three (out of five) histiocytic sarcoma cases carried somatic mutations in BRAF. Among them, G464V [variant frequency (VF) of 43.6 %] and G466R (VF of 29.6 %) located at the P loop potentially interfere with the hydrophobic interaction between P and activating loops and ultimately activation of BRAF. Also detected was BRAF somatic mutation N581S (VF of 7.4 %), which was located at the catalytic loop of BRAF kinase domain: its role in modifying kinase activity was unclear. A similar mutational analysis was also performed on nine acute monocytic/monoblastic leukemia cases, which did not identify any BRAF somatic mutations. Our study detected several BRAF mutations in histiocytic sarcomas, which may be important in understanding the tumorigenesis of this rare neoplasm and providing mechanisms for potential therapeutical opportunities. JF - Virchows Archiv. A. Pathological Anatomy and Histology AU - Liu, Qingqing AU - Tomaszewicz, Keith AU - Hutchinson, Lloyd AU - Hornick, Jason L AU - Woda, Bruce AU - Yu, Hongbo AD - Department of Pathology, UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA, USA, Hongbo.Yu@va.gov Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 233 EP - 241 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 469 IS - 2 SN - 0945-6317, 0945-6317 KW - Biotechnology and Bioengineering Abstracts KW - Tumor suppressor genes KW - Uterus KW - Tumorigenesis KW - Hydrophobicity KW - Lymph nodes KW - Differentiation KW - Leukemia KW - Pleura KW - Oncogenes KW - Sarcoma KW - Hemopoiesis KW - Monocytes KW - Mutation KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815709373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virchows+Archiv.+A.+Pathological+Anatomy+and+Histology&rft.atitle=Somatic+mutations+in+histiocytic+sarcoma+identified+by+next+generation+sequencing&rft.au=Liu%2C+Qingqing%3BTomaszewicz%2C+Keith%3BHutchinson%2C+Lloyd%3BHornick%2C+Jason+L%3BWoda%2C+Bruce%3BYu%2C+Hongbo&rft.aulast=Liu&rft.aufirst=Qingqing&rft.date=2016-08-01&rft.volume=469&rft.issue=2&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Virchows+Archiv.+A.+Pathological+Anatomy+and+Histology&rft.issn=09456317&rft_id=info:doi/10.1007%2Fs00428-016-1965-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 34 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Uterus; Tumorigenesis; Hydrophobicity; Lymph nodes; Pleura; Leukemia; Differentiation; Oncogenes; Sarcoma; Hemopoiesis; Monocytes; Mutation DO - http://dx.doi.org/10.1007/s00428-016-1965-2 ER - TY - JOUR T1 - A randomized trial of a pain management intervention for adults receiving substance use disorder treatment AN - 1811905658; PQ0003466126 AB - Background and Aims Chronic pain is difficult to treat in individuals with substance use disorders and, when not resolved, can have a negative impact on substance use disorder treatment outcomes. This study tested the efficacy of a psychosocial pain management intervention, ImPAT (improving pain during addiction treatment), that combines pain management with content related to managing pain without substance use. Design Single-site, parallel-groups randomized controlled trial comparing ImPAT to a supportive psychoeducational control (SPC) condition; follow-up assessments occurred at 3, 6 and 12 months. Setting The Ann Arbor VA Substance Use Disorder treatment program, USA. Participants Veterans Health Administration patients {n = 129; mean [standard deviation (SD)], age = 51.7 (9.5); 115 of 129 (89%) male; ImPAT (n = 65); SPC (n = 64)}. Intervention ImPAT combines principles of cognitive-behavioral therapy and acceptance-based approaches to pain management with content related to avoiding the use of substances as a coping mechanism for pain. The SPC used a psychoeducational attention control treatment for alcoholism modified to cover other substances in addition to alcohol. Measurements Primary: Pain intensity over 12 months; secondary: pain-related functioning, frequency of alcohol and drug use over 12 months. Findings Primary: randomization to the ImPAT intervention versus SPC predicted significantly lower pain intensity { beta [standard error (SE)] = -0.71 (0.29); 95% confidence interval (CI) = -1.29, -0.12}; secondary: relative to the SPC condition, those who received ImPAT also reported improved pain-related functioning [ beta (SE) = 0.27 (0.11); 95% CI = 0.05, 0.49] and lower frequency of alcohol consumption [ beta (SE) = -0.77; 95% CI = -1.34, -0.20]. No differences were found between conditions on frequency of drug use over follow-up. Conclusions For adults with pain who are enrolled in addictions treatment, receipt of a psychological pain management intervention (improving pain during addiction treatment) reduced pain and alcohol use and improves pain-related functioning over 12 months relative to a matched-attention control condition. JF - Addiction AU - Ilgen, Mark A AU - Bohnert, Amy SB AU - Chermack, Stephen AU - Conran, Carly AU - Jannausch, Mary AU - Trafton, Jodie AU - Blow, Frederic C AD - VA Center for Clinical Management Research (CCMR), Veterans Health Administration, Ann Arbor, MI, USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 1385 EP - 1393 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 111 IS - 8 SN - 0965-2140, 0965-2140 KW - Physical Education Index KW - Evaluation KW - Alcohol KW - Measurement KW - Objectives KW - Pain KW - Addiction KW - Adults KW - Drugs KW - Self efficacy KW - PE 140:Business, Marketing & Sports Equipment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811905658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=A+randomized+trial+of+a+pain+management+intervention+for+adults+receiving+substance+use+disorder+treatment&rft.au=Ilgen%2C+Mark+A%3BBohnert%2C+Amy+SB%3BChermack%2C+Stephen%3BConran%2C+Carly%3BJannausch%2C+Mary%3BTrafton%2C+Jodie%3BBlow%2C+Frederic+C&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2016-08-01&rft.volume=111&rft.issue=8&rft.spage=1385&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fadd.13349 LA - English DB - Physical Education Index N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Evaluation; Measurement; Alcohol; Objectives; Pain; Adults; Addiction; Drugs; Self efficacy DO - http://dx.doi.org/10.1111/add.13349 ER - TY - JOUR T1 - Delayed Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Inhibition by Trametinib Attenuates Systemic Inflammatory Responses and Multiple Organ Injury in Murine Sepsis. AN - 1805767479; 27031380 AB - The mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway is an essential component of innate immunity necessary for mediating proinflammatory responses in the setting of sepsis. We previously demonstrated that the mitogen-activated protein kinase 1/2 inhibitor trametinib prevents endotoxin-induced renal injury in mice. We therefore assessed efficacy of trametinib in a more clinically relevant experimental model of sepsis. Controlled in vivo laboratory study. University animal research laboratory. Male C57BL/6 mice. Mice were subjected to cecal ligation and puncture to induce sepsis or underwent sham operation as controls. Six hours after cecal ligation and puncture, mice were randomized to four experimental groups as follows: 1) sham control; 2) sham control + trametinib (1 mg/kg, IP); 3) cecal ligation and puncture; and 4) cecal ligation and puncture + trametinib. All animals received buprenorphine (0.05 mg/kg, SC) and imipenem/cilastatin (14 mg/kg, SC) in 1.5 mL of warm saline (40 mL/kg) at the 6-hour time point. Mice were euthanized at 18 hours after induction of cecal ligation and puncture. Trametinib inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase signaling 6 hours after cecal ligation and puncture attenuated increases in circulating proinflammatory cytokines (tumor necrosis factor-α, interleukin-1β, interleukin-6, and granulocyte macrophage colony-stimulating factor) and hypothermia at 18 hours. Trametinib also attenuated multiple organ injury as determined by serum creatinine, alanine aminotransferase, lactate dehydrogenase, and creatine kinase. At the organ level, trametinib completely restored peritubular capillary perfusion in the kidney. Restoration of microvascular perfusion was associated with reduced messenger RNA expression of well-characterized markers of proximal tubule injury. mitogen-activated protein kinase/extracellular signal-regulated kinase blockade attenuated cecal ligation and puncture-mediated up-regulation of cytokines (tumor necrosis factor-α, interleukin-1β) and restored interleukin-6 to control levels in the renal cortex, indicating the protective effects on the proximal tubule occur primarily through modulation of the proinflammatory response in sepsis. These data reveal that the mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor trametinib attenuates systemic inflammation and multiple organ damage in a clinically relevant model of sepsis. Because trametinib has been safely used in humans, we propose that this drug might represent a translatable approach to limit organ injury in septic patients. JF - Critical care medicine AU - Smith, Joshua A AU - Mayeux, Philip R AU - Schnellmann, Rick G AD - 1Department of Medicine, University of Colorado Denver, Aurora, CO. 2Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR. 3Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - e711 EP - e720 VL - 44 IS - 8 KW - Abridged Index Medicus KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1805767479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+care+medicine&rft.atitle=Delayed+Mitogen-Activated+Protein+Kinase%2FExtracellular+Signal-Regulated+Kinase+Inhibition+by+Trametinib+Attenuates+Systemic+Inflammatory+Responses+and+Multiple+Organ+Injury+in+Murine+Sepsis.&rft.au=Smith%2C+Joshua+A%3BMayeux%2C+Philip+R%3BSchnellmann%2C+Rick+G&rft.aulast=Smith&rft.aufirst=Joshua&rft.date=2016-08-01&rft.volume=44&rft.issue=8&rft.spage=e711&rft.isbn=&rft.btitle=&rft.title=Critical+care+medicine&rft.issn=1530-0293&rft_id=info:doi/10.1097%2FCCM.0000000000001672 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/CCM.0000000000001672 ER - TY - JOUR T1 - MicroRNA-19a/b mediates grape seed procyanidin extract-induced anti-neoplastic effects against lung cancer. AN - 1805483646; 27289489 AB - Oncomirs are microRNAs (miRNA) associated with carcinogenesis and malignant transformation. They have emerged as potential molecular targets for anti-cancer therapy. We hypothesize that grape seed procyanidin extract (GSE) exerts antineoplastic effects through modulations of oncomirs and their downstream targets. We found that GSE significantly down-regulated oncomirs miR-19a and -19b in a variety of lung neoplastic cells. GSE also increased mRNA and protein levels of insulin-like growth factor II receptor (IGF-2R) and phosphatase and tensin homolog (PTEN), both predicted targets of miR-19a and -19b. Furthermore, GSE significantly increased PTEN activity and decreased AKT phosphorylation in A549 cells. Transfection of miR-19a and -19b mimics reversed the up-regulations of IGF2R and PTEN gene expression and abrogated the GSE induced anti-proliferative response. Additionally, oral administration of leucoselect phytosome, comprised of standardized grape seed oligomeric procyanidins complexed with soy phospholipids, to athymic nude mice via gavage, significantly down-regulated miR-19a, -19b and the miR-17-92 cluster host gene (MIR17HG) expressions, increased IGF-2R, PTEN, decreased phosphorylated-AKT in A549 xenograft tumors, and markedly inhibited tumor growth. To confirm the absorption of orally administered GSE, plasma procyanidin B1 levels, between 60 and 90 min after gavage of leucoselect phytosome (400 mg/kg), were measured by LC/MS at week 2 and 8 of treatment; the estimated concentration that was associated with 50% growth inhibition (IC50) (1.3 μg/mL) in vitro was much higher than the IC50 (0.032-0.13 μg/ml) observed in vivo. Our findings reveal novel antineoplastic mechanisms by GSE and support the clinical translation of leucoselect phytosome as an anti-neoplastic and chemopreventive agent for lung cancer. Published by Elsevier Inc. JF - The Journal of nutritional biochemistry AU - Mao, Jenny T AU - Xue, Bingye AU - Smoake, Jane AU - Lu, Qing-Yi AU - Park, Heesung AU - Henning, Susanne M AU - Burns, Windie AU - Bernabei, Alvise AU - Elashoff, David AU - Serio, Kenneth J AU - Massie, Larry AD - Pulmonary, Critical Care, and Sleep Section, New Mexico Veterans Administration Health Care System, University of New, Mexico. Electronic address: jenny.mao@va.gov. ; Pulmonary, Critical Care, and Sleep Section, New Mexico Veterans Administration Health Care System, University of New, Mexico. ; UCLA Center for Human Nutrition, David Geffen School of Medicine at UCLA. ; Pathology and Clinical Laboratory Services, New Mexico Veterans Administration Health Care System, University of New, Mexico. ; Cardiothoracic Surgery Section, New Mexico Veterans Administration Health Care System, University of New, Mexico. ; Department of Biostatistics, Department of Medicine, David Geffen School of Medicine at UCLA. ; Pulmonary & Critical Care Medicine, Scripps Green Hospital. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 118 EP - 125 VL - 34 KW - Index Medicus KW - Grape seed procyanidin B1 bioavailability KW - MiRNA KW - IGF-2R KW - AKT KW - PTEN UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1805483646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutritional+biochemistry&rft.atitle=MicroRNA-19a%2Fb+mediates+grape+seed+procyanidin+extract-induced+anti-neoplastic+effects+against+lung+cancer.&rft.au=Mao%2C+Jenny+T%3BXue%2C+Bingye%3BSmoake%2C+Jane%3BLu%2C+Qing-Yi%3BPark%2C+Heesung%3BHenning%2C+Susanne+M%3BBurns%2C+Windie%3BBernabei%2C+Alvise%3BElashoff%2C+David%3BSerio%2C+Kenneth+J%3BMassie%2C+Larry&rft.aulast=Mao&rft.aufirst=Jenny&rft.date=2016-08-01&rft.volume=34&rft.issue=&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutritional+biochemistry&rft.issn=1873-4847&rft_id=info:doi/10.1016%2Fj.jnutbio.2016.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jnutbio.2016.05.003 ER - TY - JOUR T1 - Edentulism and transplant-associated complications in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. AN - 1799559262; 26984247 AB - Patients undergoing autologous hematopoietic stem cell transplantation (HSCT) are at risk for oral complications which may cause significant morbidity. The aim of this study was to compare the incidence of toxicities and complications in edentulous and dentate patients undergoing autologous HSCT for multiple myeloma. We conducted a retrospective case-control study to analyze the incidence of bacteremia, fever, and oral mucositis, between edentulous and dentate patients. All patients underwent dental evaluation, received dental treatment if indicated, and were cleared before transplantation. The two groups were matched for age, gender, ethnicity, disease stage, time from diagnosis to transplant, performance status, and conditioning regimen. A total of 45 edentulous and 90 dentate patients were enrolled. All patients were male with a median age of 60 years and a mean performance status by Karnofsky score of 90 %. Two thirds had stage III MM with a median time from diagnosis to transplantation of 12 months, and all received melphalan as part of the conditioning regimen. The incidence of bacteremia (p = 0.553), fever (p = 0.245), severity of oral mucositis (p = 0.465), and other post-transplant toxicities were similar between both groups. There were no significant differences in the incidence of bacteremia, fever, severity of oral mucositis, or other complications between edentulous and dentate patients with multiple myeloma after autologous HSCT. JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer AU - Toro, Juan Jose AU - Gushiken, Francisca Cecilia AU - Schneider, Deanna AU - Lee, Shuko AU - Haile, David Johannes AU - Freytes, Cesar Ovidio AD - Audie L. Murphy Memorial Veterans Hospital, South Texas Veterans Health Care System, 7400 Merton Minter Blvd., San Antonio, TX, 78229, USA. Juan.toro2@va.gov. ; Audie L. Murphy Memorial Veterans Hospital, South Texas Veterans Health Care System, 7400 Merton Minter Blvd., San Antonio, TX, 78229, USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 3411 EP - 3415 VL - 24 IS - 8 KW - Index Medicus KW - Post-transplant toxicities KW - Multiple myeloma KW - Oral complications KW - Autologous hematopoietic stem cell transplantation KW - Edentulous KW - Dentate UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1799559262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.atitle=Edentulism+and+transplant-associated+complications+in+patients+with+multiple+myeloma+undergoing+autologous+hematopoietic+stem+cell+transplantation.&rft.au=Toro%2C+Juan+Jose%3BGushiken%2C+Francisca+Cecilia%3BSchneider%2C+Deanna%3BLee%2C+Shuko%3BHaile%2C+David+Johannes%3BFreytes%2C+Cesar+Ovidio&rft.aulast=Toro&rft.aufirst=Juan&rft.date=2016-08-01&rft.volume=24&rft.issue=8&rft.spage=3411&rft.isbn=&rft.btitle=&rft.title=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.issn=1433-7339&rft_id=info:doi/10.1007%2Fs00520-016-3168-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00520-016-3168-4 ER - TY - JOUR T1 - Religious Well-Being and Suicide Ideation in Veterans - An Exploratory Study AN - 1798991861 AB - Religious well-being is a multi-faceted construct posited as a protective factor against suicidal thoughts and behaviors. This cross-sectional, exploratory study used religious practice data collected from n=5378 U.S. military veterans to create composite measures of private and public religious practice. These composite measures were subsequently used to determine the probability of being identified with a history of suicide ideation. Data analysis was conducted using logistic regression. Veterans with a history of suicide ideation made up 10.2 % (n=549) of the sample. Such veterans had significantly lower mean public and private religiosity scores compared to those without ideation. Differences between these two composite measures of religiosity were associated with a higher probability of being identified with a history of suicide ideation. The present study adds to the extant literature by presenting a framework for interpreting religious well-being in the context of religious practice. Quantitative differences in engagement between private and public practices may be indicative of a decreased sense of religious well-being, conferring less protection against suicidal behavior. JF - Pastoral Psychology AU - Kopacz, Marek S AU - Morley, Sybil W AU - Woniak, Barbara M AU - Simons, Kelsey V AU - Bishop, Todd M AU - Vance, C Garland AD - U.S. Department of Veterans Affairs, VISN 2 Center of Excellence for Suicide Prevention, Canandaigua, NY, USA ; Department of Medical Sociology, Jagiellonian University Medical College, Kraków, Poland ; U.S. Department of Veterans Affairs, VISN 2 Center of Excellence for Suicide Prevention, Canandaigua, NY, USA; University of Rochester Medical Center, Rochester, NY, USA ; U.S. Department of Veterans Affairs, Charles George VA Medical Center, Asheville, NC, USA Y1 - 2016/08// PY - 2016 DA - Aug 2016 SP - 481 EP - 491 CY - New York PB - Springer Science & Business Media VL - 65 IS - 4 SN - 0031-2789 KW - Religions And Theology KW - Veterans KW - Suicide ideation KW - Religious practice KW - Religious well-being KW - Protective factors KW - Religious aspects KW - Wellbeing KW - Suicidal behaviour KW - Suicidal ideation KW - Suicide KW - Religiosity KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1798991861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pastoral+Psychology&rft.atitle=Religious+Well-Being+and+Suicide+Ideation+in+Veterans+-+An+Exploratory+Study&rft.au=Kopacz%2C+Marek+S%3BMorley%2C+Sybil+W%3BWoniak%2C+Barbara+M%3BSimons%2C+Kelsey+V%3BBishop%2C+Todd+M%3BVance%2C+C+Garland&rft.aulast=Kopacz&rft.aufirst=Marek&rft.date=2016-08-01&rft.volume=65&rft.issue=4&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Pastoral+Psychology&rft.issn=00312789&rft_id=info:doi/10.1007%2Fs11089-016-0699-z LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Springer Science+Business Media New York 2016 N1 - Last updated - 2016-06-29 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1007/s11089-016-0699-z ER - TY - JOUR T1 - Examining the differences in current regulatory processes for sunscreens and proposed safety assessment paradigm. AN - 1794469003; 27016397 AB - Skin cancers including malignant melanoma which are due to UV radiation constitute a serious public health problem. Recent studies have confirmed the importance of UVA radiation in the pathogenesis of skin cancer, as well as the protective effects of broad-spectrum sunscreen use. Barriers for effective protection of the US public include the lack of effective UV filters, especially in the UVA spectrum. The major reason for the paucity of UVA-effective filters in the US is due primarily to the FDA's reluctance to approve agents which have already been on the market in Europe and elsewhere in the world for more than a decade. The underlying reasons for these discrepancies in new sunscreen approval success between the US and abroad are complex, and include factors such as that the FDA considers UV filters as drugs, whereas they are regulated as cosmetics elsewhere. FDA has not as yet developed a consistent approach for the approval of new UV filters. We provide a paradigm for both non-clinical testing and human safety testing which includes parameters for a human maximum use test (MUsT) that is based upon both ethical and scientific concepts. These suggestions could form the basis of future regulatory guidelines for rational testing thus allowing us to reach the consensus goal of more efficient and timely approval of much-needed UV filters to provide protection for the US public. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Sargent, Edward V AU - Travers, Jeffrey B AD - Rutgers University, School of Public Health, Piscataway, NJ, USA. Electronic address: evsargent@gmail.com. ; Wright State University, Dayton, OH, USA; Dayton Veterans Administration Medical Center, Dayton, OH, USA. Electronic address: Jeffrey.travers@wright.edu. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 125 EP - 141 VL - 79 KW - Index Medicus KW - Safety testing KW - Non-clinical KW - Human KW - UV filters KW - Sunscreens KW - Skin cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1794469003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Examining+the+differences+in+current+regulatory+processes+for+sunscreens+and+proposed+safety+assessment+paradigm.&rft.au=Sargent%2C+Edward+V%3BTravers%2C+Jeffrey+B&rft.aulast=Sargent&rft.aufirst=Edward&rft.date=2016-08-01&rft.volume=79&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.03.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.03.008 ER - TY - JOUR T1 - A Lens Model Approach to the Communication of Pain AN - 1792708495 AB - Two studies examined the expression and detection of suppressed, genuine, and exaggerated pain. In Study 1, videotaped participants underwent an acute laboratory pain stressor and completed pain ratings. In Study 2, the lens model examined the cues encoders displayed while in pain (facial expressions of pain and viewers' global impressions), the cues decoders used to infer pain in the videotaped encoders, and decoders' accuracy in making judgments of pain. Results revealed expression differences between the suppressed, genuine, and exaggerated pain such that exaggerated expressions contained more tightened facial expressions while genuine expressions of pain contained more open facial expressions of pain. Decoders were accurate at detecting pain only in the exaggerated pain expressions. These results highlight the need for improving providers' accuracy in detecting pain intensity for suppressed, genuine, and exaggerated pain displays. Trainings should focus on teaching providers that patients who appear more agitated and less composed may be suppressing pain, while patients who appear more tense and determined may be exaggerating pain. Finally, patients who seem to not be in that much pain because they are not showing tightened facial expressions may actually be experiencing higher intensities of genuine pain. JF - Health Communication AU - Ruben, Mollie A AU - Hall, Judith A AD - Center for Healthcare Organization and Implementation Research, U.S. Department of Veterans Affairs ; Department of Psychology, Northeastern University Y1 - 2016/08// PY - 2016 DA - Aug 2016 SP - 934 EP - 945 CY - Mahwah PB - Taylor & Francis Ltd. VL - 31 IS - 8 SN - 1041-0236 KW - Public Health And Safety KW - Pain KW - Accuracy KW - Cues KW - Detection KW - Displays KW - Facial expressions KW - Impressions KW - Judgments KW - Suppressed KW - Teaching KW - Viewers KW - Communication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1792708495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Communication&rft.atitle=A+Lens+Model+Approach+to+the+Communication+of+Pain&rft.au=Ruben%2C+Mollie+A%3BHall%2C+Judith+A&rft.aulast=Ruben&rft.aufirst=Mollie&rft.date=2016-08-01&rft.volume=31&rft.issue=8&rft.spage=934&rft.isbn=&rft.btitle=&rft.title=Health+Communication&rft.issn=10410236&rft_id=info:doi/10.1080%2F10410236.2015.1020261 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © 2016 Taylor & Francis N1 - Last updated - 2016-06-01 DO - http://dx.doi.org/10.1080/10410236.2015.1020261 ER - TY - JOUR T1 - Inhibition of FoxM1-Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis. AN - 1804867546; 26927663 AB - The approaches aimed at inhibiting the ability of cancer cells to repair DNA strand breaks have emerged as promising targets for treating cancers. Here, we assessed the potential of imipramine blue (IB), a novel analogue of antidepressant imipramine, to suppress breast cancer growth and metastasis by inhibiting the ability of breast cancer cells to repair DNA strand breaks by homologous recombination (HR). The effect of IB on breast cancer growth and metastasis was assessed in vitro as well as in preclinical mouse models. Besides, the therapeutic efficacy and safety of IB was determined in ex vivo explants from breast cancer patients. The mechanism of action of IB was evaluated by performing gene-expression, drug-protein interaction, cell-cycle, and DNA repair studies. We show that the systemic delivery of IB using nanoparticle-based delivery approach suppressed breast cancer growth and metastasis without inducing toxicity in preclinical mouse models. Using ex vivo explants from breast cancer patients, we demonstrated that IB inhibited breast cancer growth without affecting normal mammary epithelial cells. Furthermore, our mechanistic studies revealed that IB may interact and inhibit the activity of proto-oncogene FoxM1 and associated signaling that play critical roles in HR-mediated DNA repair. These findings highlight the potential of IB to be applied as a safe regimen for treating breast cancer patients. Given that FoxM1 is an established therapeutic target for several cancers, the identification of a compound that inhibits FoxM1- and FoxM1-mediated DNA repair has immense translational potential for treating many aggressive cancers. Clin Cancer Res; 22(14); 3524-36. ©2016 AACR. ©2016 American Association for Cancer Research. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Rajamanickam, Subapriya AU - Panneerdoss, Subbarayalu AU - Gorthi, Aparna AU - Timilsina, Santosh AU - Onyeagucha, Benjamin AU - Kovalskyy, Dmytro AU - Ivanov, Dmitri AU - Hanes, Martha A AU - Vadlamudi, Ratna K AU - Chen, Yidong AU - Bishop, Alexander J AU - Arbiser, Jack L AU - Rao, Manjeet K AD - Department of Cell and Structure Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas. Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas. ; Department of Biochemistry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas. ; Department of Laboratory Animal Resources, The University of Texas Health Science Center at San Antonio, San Antonio, Texas. ; Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas. ; Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas. Department of Epidemiology and Statistics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas. ; Emory School of Medicine, Atlanta, Georgia. Veterans Administration Medical Center, Atlanta, Georgia. ; Department of Cell and Structure Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas. Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas. raom@uthscsa.edu. Y1 - 2016/07/15/ PY - 2016 DA - 2016 Jul 15 SP - 3524 EP - 3536 VL - 22 IS - 14 SN - 1078-0432, 1078-0432 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1804867546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Inhibition+of+FoxM1-Mediated+DNA+Repair+by+Imipramine+Blue+Suppresses+Breast+Cancer+Growth+and+Metastasis.&rft.au=Rajamanickam%2C+Subapriya%3BPanneerdoss%2C+Subbarayalu%3BGorthi%2C+Aparna%3BTimilsina%2C+Santosh%3BOnyeagucha%2C+Benjamin%3BKovalskyy%2C+Dmytro%3BIvanov%2C+Dmitri%3BHanes%2C+Martha+A%3BVadlamudi%2C+Ratna+K%3BChen%2C+Yidong%3BBishop%2C+Alexander+J%3BArbiser%2C+Jack+L%3BRao%2C+Manjeet+K&rft.aulast=Rajamanickam&rft.aufirst=Subapriya&rft.date=2016-07-15&rft.volume=22&rft.issue=14&rft.spage=3524&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-15-2535 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1078-0432.CCR-15-2535 ER - TY - JOUR T1 - Meeting the Treatment Needs of Veterans with Substance Use Disorders AN - 1808626944; PQ0003359735 AB - Substance use disorder (SUD) treatment staff from the Brooklyn Veterans Administration Hospital and Samaritan Village describe current practices and challenges in treating the increasing Veteran population with SUD. Article addresses best practices for treating Veterans with SUDs, posttraumatic stress disorder, and traumatic brain injury complications; military sexual trauma; combat versus noncombat status; significance of period served (WW II, Korea, Vietnam, Kuwait/Iraq I, Iraq II, Afghanistan); active service obligations; treatment interventions for trauma survivors; gender treatment differences; medically assisted treatments, especially for those with pain issues; family involvement; benefit seeking; self-help Step 1's "surrender" and "powerlessness" terms; access to treatment issues; returning home adjustment; and coordinating interdisciplinary treatment services. JF - Alcoholism AU - Carroll, Jerome FX AU - Hall, Charles E AU - Kearse, Roy AU - Mooney, Michael AU - Potestivo, Jo AU - Forman, Nancy AD - Psychology Department/Ambulatory Substance Abuse Program, Brooklyn Veterans Administration Hospital, Brooklyn, New York, USA Y1 - 2016/07/02/ PY - 2016 DA - 2016 Jul 02 SP - 354 EP - 364 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 34 IS - 3 SN - 0734-7324, 0734-7324 KW - Toxicology Abstracts KW - Alcoholism KW - Pain KW - Traumatic brain injury KW - Drug abuse KW - Post-traumatic stress disorder KW - Hospitals KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808626944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism&rft.atitle=Meeting+the+Treatment+Needs+of+Veterans+with+Substance+Use+Disorders&rft.au=Carroll%2C+Jerome+FX%3BHall%2C+Charles+E%3BKearse%2C+Roy%3BMooney%2C+Michael%3BPotestivo%2C+Jo%3BForman%2C+Nancy&rft.aulast=Carroll&rft.aufirst=Jerome&rft.date=2016-07-02&rft.volume=34&rft.issue=3&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=Alcoholism&rft.issn=07347324&rft_id=info:doi/10.1080%2F07347324.2016.1182820 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Alcoholism; Pain; Drug abuse; Traumatic brain injury; Post-traumatic stress disorder; Hospitals DO - http://dx.doi.org/10.1080/07347324.2016.1182820 ER - TY - JOUR T1 - Periconceptional seafood intake and pregnancy complications AN - 1846409598; PQ0003835504 AB - To investigate associations of maternal periconceptional shellfish, lean fish and fatty fish intake with risk of pregnancy complications. In this prospective cohort study, we collected information on intake of seafood subtypes using FFQ. We categorized seafood intake into frequencies of 1 servings/week. We ascertained gestational hypertension, pre-eclampsia, gestational diabetes and preterm birth diagnoses from medical records. Using generalized linear models with a log link, the Poisson family and robust standard errors, we estimated risk ratios and 95 % confidence intervals across seafood intake categories. The Omega study, a study of risk factors for pregnancy complications among women recruited from prenatal clinics in Washington State, USA, 1996-2008. The current study included 3279 participants from the Omega study. Median (interquartile range) shellfish, lean fish and fatty fish intake was 0.3 (0-0.9), 0.5 (0-1.0) and 0.5 (0.1-1.0) servings/week, respectively. Lean fish intake of >1 servings/week (v. <0.2 servings/month) was associated with a 1.55-fold higher risk of preterm birth (95 % CI 1.04, 2.30) and was not associated with the other pregnancy complications. Higher intake of seafood (total or other subtypes) was not associated with pregnancy complications (separately or combined). Higher intake of lean fish, but not fatty fish or shellfish, was associated with a higher risk of preterm birth; these findings may have significance for preterm birth prevention. Studies of mechanisms and potential contributing factors (including seafood preparation and nutrient/contaminant content) are warranted. JF - Public Health Nutrition AU - Mohanty, April F AU - Siscovick, David S AU - Williams, Michelle A AU - Thompson, Mary Lou AU - Burbacher, Thomas M AU - Enquobahrie, Daniel A AD - Cardiovascular Health Research Unit, Department of Medicine and Department of Epidemiology, University of Washington, Seattle, WA, USA, april.mohanty@va.gov Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 1795 EP - 1803 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 19 IS - 10 SN - 1368-9800, 1368-9800 KW - Health & Safety Science Abstracts; Calcium & Calcified Tissue Abstracts KW - Prenatal experience KW - Nutrients KW - INE, USA, Washington KW - Public health KW - Models KW - Risk factors KW - Pre-eclampsia KW - Seafood KW - Complications KW - medical records KW - Pregnancy KW - Birth KW - Diabetes mellitus KW - Nutrient content KW - Prevention KW - Pregnancy complications KW - Fish KW - Shellfish KW - Contaminants KW - Hypertension KW - H 11000:Diseases/Injuries/Trauma KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846409598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Nutrition&rft.atitle=Periconceptional+seafood+intake+and+pregnancy+complications&rft.au=Mohanty%2C+April+F%3BSiscovick%2C+David+S%3BWilliams%2C+Michelle+A%3BThompson%2C+Mary+Lou%3BBurbacher%2C+Thomas+M%3BEnquobahrie%2C+Daniel+A&rft.aulast=Mohanty&rft.aufirst=April&rft.date=2016-07-01&rft.volume=19&rft.issue=10&rft.spage=1795&rft.isbn=&rft.btitle=&rft.title=Public+Health+Nutrition&rft.issn=13689800&rft_id=info:doi/10.1017%2FS136898001500316X LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 28 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Birth; Pregnancy complications; medical records; Risk factors; Pre-eclampsia; Nutrients; Seafood; Contaminants; Models; Hypertension; Public health; Nutrient content; Prevention; Prenatal experience; Complications; Shellfish; Fish; Pregnancy; INE, USA, Washington DO - http://dx.doi.org/10.1017/S136898001500316X ER - TY - JOUR T1 - Initial Assessment of the Molecular Epidemiology of blaNDM-1 in Colombia AN - 1808677721; PQ0003483856 AB - We report complete genome sequences of four blaNDM-1-harboring Gram-negative multidrug-resistant (MDR) isolates from Colombia. The blaNDM-1 genes were located on 193-kb Inc FIA, 178-kb Inc A/C2, and 47-kb (unknown Inc type) plasmids. Multilocus sequence typing (MLST) revealed that these isolates belong to sequence type 10 (ST10) (Escherichia coli), ST392 (Klebsiella pneumoniae), and ST322 and ST464 (Acinetobacter baumannii and Acinetobacter nosocomialis, respectively). Our analysis identified that the Inc A/C2 plasmid in E. coli contained a novel complex transposon (Tn125 and Tn5393 with three copies of blaNDM-1) and a recombination "hot spot" for the acquisition of new resistance determinants. JF - Antimicrobial Agents & Chemotherapy AU - Rojas, Laura J AU - Wright, Meredith S AU - La Cadena, Elsa De AU - Motoa, Gabriel AU - Hujer, Kristine M AU - Villegas, Maria V AU - Adams, Mark D AU - Bonomo, Robert A AD - << + $0, robert.bonomo@va.gov. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 4346 EP - 4350 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 60 IS - 7 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Genomes KW - Hot spots KW - Drug resistance KW - Plasmids KW - multilocus sequence typing KW - Transposons KW - Recombination KW - Acinetobacter KW - Acinetobacter baumannii KW - Epidemiology KW - Escherichia coli KW - Klebsiella pneumoniae KW - A 01380:Plant Protection, Fungicides & Seed Treatments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808677721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Initial+Assessment+of+the+Molecular+Epidemiology+of+blaNDM-1+in+Colombia&rft.au=Rojas%2C+Laura+J%3BWright%2C+Meredith+S%3BLa+Cadena%2C+Elsa+De%3BMotoa%2C+Gabriel%3BHujer%2C+Kristine+M%3BVillegas%2C+Maria+V%3BAdams%2C+Mark+D%3BBonomo%2C+Robert+A&rft.aulast=Rojas&rft.aufirst=Laura&rft.date=2016-07-01&rft.volume=60&rft.issue=7&rft.spage=4346&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.03072-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 36 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Transposons; Genomes; Recombination; Epidemiology; Hot spots; Drug resistance; Plasmids; multilocus sequence typing; Acinetobacter baumannii; Acinetobacter; Escherichia coli; Klebsiella pneumoniae DO - http://dx.doi.org/10.1128/AAC.03072-15 ER - TY - JOUR T1 - Intimate partner violence, partner notification, and expedited partner therapy: a qualitative study AN - 1808616856; PQ0003281275 AB - Summary Over one-third of women experience intimate partner violence (IPV) in their lifetime. IPV increases the risk of infection and re-infection with sexually transmitted infections (STIs). The extent to which health care providers consider IPV when recommending partner notification and expedited partner therapy is unknown. The objective of this qualitative study was to understand health care providers' views on IPV and STIs when recommending partner treatment to patients with chlamydia. Using a purposive sampling strategy to include health care providers who treat young women at risk for chlamydia, 23 semi-structured, in-depth interviews were conducted. While some health care providers expressed concern for their patients' safety and believed assessing for IPV was needed before provision of expedited partner therapy, nearly a third had not considered the links between IPV and STIs. Strategies used by health care providers to assess for IPV did not include inquiry about specific behaviours related to IPV, STI risk, and sexual coercion. Many health care providers understand the risk for IPV in the setting of STI treatment, yet a significant portion of those interviewed failed to recognise the link between IPV and STIs. Provider education is necessary to increase knowledge and implement more effective inquiry and counselling about IPV to more safely recommend expedited partner therapy. JF - International Journal of STD & AIDS AU - Rosenfeld, Elian A AU - Marx, John AU - Terry, Martha A AU - Stall, Ronald AU - Pallatino, Chelsea AU - Borrero, Sonya AU - Miller, Elizabeth AD - 1 .VA Women's Health, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA, elian.rosenfeld@va.gov Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 656 EP - 661 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 United States VL - 27 IS - 8 SN - 0956-4624, 0956-4624 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Intimate partner violence KW - sexually transmitted infections KW - treatment KW - sexual violence KW - partner notification KW - expedited partner therapy KW - Risk assessment KW - Acquired immune deficiency syndrome KW - Safety KW - Infection KW - Health risks KW - Health care KW - Infectious diseases KW - Coercion KW - Domestic violence KW - Sampling KW - Aggression KW - Sexually transmitted diseases KW - Chlamydia KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808616856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=Intimate+partner+violence%2C+partner+notification%2C+and+expedited+partner+therapy%3A+a+qualitative+study&rft.au=Rosenfeld%2C+Elian+A%3BMarx%2C+John%3BTerry%2C+Martha+A%3BStall%2C+Ronald%3BPallatino%2C+Chelsea%3BBorrero%2C+Sonya%3BMiller%2C+Elizabeth&rft.aulast=Rosenfeld&rft.aufirst=Elian&rft.date=2016-07-01&rft.volume=27&rft.issue=8&rft.spage=656&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/10.1177%2F0956462415591938 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 26 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Sampling; Aggression; Infection; Risk assessment; Health risks; Acquired immune deficiency syndrome; Infectious diseases; Health care; Safety; Coercion; Domestic violence; Sexually transmitted diseases; Chlamydia DO - http://dx.doi.org/10.1177/0956462415591938 ER - TY - JOUR T1 - Premalignant Oral Lesion Cells Elicit Increased Cytokine Production and Activation of T-cells. AN - 1800702010; 27354582 AB - Head and neck squamous cell carcinomas (HNSCC) are known to evade the host immune response. How premalignant oral lesions modulate the immune response, however, has yet to be elucidated. A mouse model of oral carcinogenesis was used to determine how mediators from premalignant oral lesion cells vs. HNSCC cells impact on immune cytokine production and activation. Media conditioned by premalignant lesion cells elicited an increased production of T cell-associated cytokines and proinflammatory mediators from cervical lymph node cells compared to media conditioned by HNSCC cells or media alone. In the presence of premalignant lesion cell-conditioned media, CD4(+) T cell expression of the IL-2 receptor CD25 and CD8(+) T cell expression of the activation marker CD69 was greater, compared to what was induced in HNSCC cell-conditioned media or media alone. Premalignant lesion cells promote a proinflammatory environment and induce immune changes before HNSCC tumors are established. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. JF - Anticancer research AU - Johnson, Sara D AU - Levingston, Corinne AU - Young, M Rita I AD - Research Service (151) Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, U.S.A. Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, U.S.A. Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, U.S.A. ; Research Service (151) Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, U.S.A. ; Research Service (151) Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, U.S.A. Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, U.S.A. Department of Medicine, Medical University of South Carolina, Charleston, SC, U.S.A. rita.young@va.gov. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 3261 EP - 3270 VL - 36 IS - 7 KW - Cytokines KW - 0 KW - Interleukin-2 Receptor alpha Subunit KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - cytokines KW - head and neck cancer KW - T cell activation KW - premalignant oral lesions KW - Lymphocyte Activation KW - Animals KW - Tumor Cells, Cultured KW - Mice, Inbred C57BL KW - Interferon-gamma -- biosynthesis KW - Disease Models, Animal KW - Mice KW - Interleukin-2 Receptor alpha Subunit -- immunology KW - Interferon-gamma -- immunology KW - Female KW - Interleukin-2 Receptor alpha Subunit -- biosynthesis KW - Carcinoma, Squamous Cell -- immunology KW - Mouth Neoplasms -- immunology KW - CD8-Positive T-Lymphocytes -- immunology KW - Cytokines -- biosynthesis KW - Cytokines -- immunology KW - CD4-Positive T-Lymphocytes -- immunology KW - Precancerous Conditions -- immunology KW - Head and Neck Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1800702010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+research&rft.atitle=Premalignant+Oral+Lesion+Cells+Elicit+Increased+Cytokine+Production+and+Activation+of+T-cells.&rft.au=Johnson%2C+Sara+D%3BLevingston%2C+Corinne%3BYoung%2C+M+Rita+I&rft.aulast=Johnson&rft.aufirst=Sara&rft.date=2016-07-01&rft.volume=36&rft.issue=7&rft.spage=3261&rft.isbn=&rft.btitle=&rft.title=Anticancer+research&rft.issn=1791-7530&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-06 N1 - Date created - 2016-06-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Approach to the Treatment of Methanol Intoxication. AN - 1799836777; 27180631 AB - Methanol intoxication is an uncommon but serious poisoning. Its adverse effects are due primarily to the impact of its major metabolite formic acid and lactic acid resulting from cellular hypoxia. Symptoms including abdominal pain and loss of vision can appear a few hours to a few days after exposure, reflecting the time necessary for accumulation of the toxic byproducts. In addition to a history of exposure, increases in serum osmolal and anion gaps can be clues to its presence. However, increments in both parameters can be absent depending on the nature of the toxic alcohol, time of exposure, and coingestion of ethanol. Definitive diagnosis requires measurement with gas or liquid chromatography, which are laborious and expensive procedures. Tests under study to detect methanol or its metabolite formate might facilitate the diagnosis of this poisoning. Treatment can include administration of ethanol or fomepizole, both inhibitors of the enzyme alcohol dehydrogenase to prevent formation of its metabolites, and hemodialysis to remove methanol and formate. In this Acid-Base and Electrolyte Teaching Case, a patient with methanol intoxication due to ingestion of model airplane fuel is described, and the value and limitations of current and new diagnostic and treatment measures are discussed. Published by Elsevier Inc. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Kraut, Jeffrey A AD - Medical and Research Services Veterans Administration Greater Los Angeles Healthcare System, UCLA Membrane Biology Laboratory, and Division of Nephrology, Veterans Administration Greater Los Angeles Healthcare System, and David Geffen School of Medicine, Los Angeles, CA. Electronic address: jkraut@ucla.edu. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 161 EP - 167 VL - 68 IS - 1 KW - Index Medicus KW - ethanol KW - methanol intoxication KW - fomepizole KW - serum osmolal gap KW - serum anion gap KW - hemodialysis KW - methanol KW - Toxic alcohols UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1799836777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Approach+to+the+Treatment+of+Methanol+Intoxication.&rft.au=Kraut%2C+Jeffrey+A&rft.aulast=Kraut&rft.aufirst=Jeffrey&rft.date=2016-07-01&rft.volume=68&rft.issue=1&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=1523-6838&rft_id=info:doi/10.1053%2Fj.ajkd.2016.02.058 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1053/j.ajkd.2016.02.058 ER - TY - JOUR T1 - Meeting the Treatment Needs of Veterans with Substance Use Disorders AN - 1798807318 AB - Substance use disorder (SUD) treatment staff from the Brooklyn Veterans Administration Hospital and Samaritan Village describe current practices and challenges in treating the increasing Veteran population with SUD. Article addresses best practices for treating Veterans with SUDs, posttraumatic stress disorder, and traumatic brain injury complications; military sexual trauma; combat versus noncombat status; significance of period served (WW II, Korea, Vietnam, Kuwait/Iraq I, Iraq II, Afghanistan); active service obligations; treatment interventions for trauma survivors; gender treatment differences; medically assisted treatments, especially for those with pain issues; family involvement; benefit seeking; self-help Step 1's "surrender" and "powerlessness" terms; access to treatment issues; returning home adjustment; and coordinating interdisciplinary treatment services. JF - Alcoholism Treatment Quarterly AU - Carroll, Jerome F X, PhD AU - Hall, Charles E, ThD AU - Kearse, Roy, LCSW, CASAC AU - Mooney, Michael, LCSW AU - Potestivo, Jo, LCSW-R, C-CATODSW AU - Forman, Nancy, MD AD - Psychology Department/Ambulatory Substance Abuse Program, Brooklyn Veterans Administration Hospital, Brooklyn, New York, USA ; Chaplain Services, Brooklyn Veterans Administration Hospital, Brooklyn, New York, USA ; Recovery and Community Partnerships for Samaritan Village, Queens, New York, USA ; Ambulatory Substance Abuse Program, Brooklyn Veterans Administration Hospital, Brooklyn, New York, USA ; Psychiatry/Ambulatory Substance Abuse Program, Brooklyn Veterans Administration Hospital, Brooklyn, New York, USA Y1 - 2016///Jul/Sep PY - 2016 DA - Jul/Sep 2016 SP - 354 EP - 364 CY - Abingdon PB - Taylor & Francis Ltd. VL - 34 IS - 3 SN - 0734-7324 KW - Drug Abuse And Alcoholism KW - Veterans KW - posttraumatic stress disorders KW - traumatic brain injuries KW - trauma-informed treatment KW - abstinence KW - harm reduction KW - evidence-based practices KW - ecological dysfunction model KW - medical model KW - integrated KW - holistic KW - comprehensive treatment KW - substitute therapies and other medically assisted treatments KW - surrender and powerlessness concepts KW - gender treatment differences KW - spirituality issues KW - Brain KW - Sex Differences KW - Adjustment KW - Treatment Methods KW - Sex KW - Management KW - Substance Abuse KW - Trauma KW - Self Help KW - Stress KW - Armed Forces KW - Posttraumatic Stress Disorder KW - Alienation KW - Injuries KW - Afghanistan KW - Kuwait KW - Iraq KW - Vietnam KW - 6129:addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1798807318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism+Treatment+Quarterly&rft.atitle=Meeting+the+Treatment+Needs+of+Veterans+with+Substance+Use+Disorders&rft.au=Carroll%2C+Jerome+F+X%2C+PhD%3BHall%2C+Charles+E%2C+ThD%3BKearse%2C+Roy%2C+LCSW%2C+CASAC%3BMooney%2C+Michael%2C+LCSW%3BPotestivo%2C+Jo%2C+LCSW-R%2C+C-CATODSW%3BForman%2C+Nancy%2C+MD&rft.aulast=Carroll&rft.aufirst=Jerome+F&rft.date=2016-07-01&rft.volume=34&rft.issue=3&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=Alcoholism+Treatment+Quarterly&rft.issn=07347324&rft_id=info:doi/10.1080%2F07347324.2016.1182820 LA - English DB - Social Services Abstracts N1 - Name - Department of Veterans Affairs N1 - Copyright - © 2016 Taylor & Francis N1 - Last updated - 2016-09-26 N1 - SubjectsTermNotLitGenreText - Afghanistan; Vietnam; Iraq; Kuwait DO - http://dx.doi.org/10.1080/07347324.2016.1182820 ER - TY - JOUR T1 - Intimate Partner Violence Screening in a Women Veterans' Health Clinic: Assessing Feasibility AN - 1794492397 AB - Women presenting for care within a suburban Department of Veterans Affairs Hospital (VA) were screened for intimate partner violence (IPV). This study aimed to explore the feasibility of screening for IPV within a VA women's health clinic, assess how well the screening measure captured women veterans' experiences of IPV, and compare clinical correlates of IPV in women veterans who have and have not experienced IPV. Of 96 eligible women, 93 (97 %) answered a self-report question regarding experience of lifetime IPV and 72 (75 %) participated in a standardized screening. Among participants, 42 (47 %) reported experiencing past or current IPV, and of those, 11 (25 %) reported that they were currently experiencing IPV, and 31 (70 %) reported that they had experienced IPV in their past. Screening for IPV among women veterans in a women's health clinic is feasible and identifies women who experience IPV, offering opportunities for referral and intervention. JF - Journal of Family Violence AU - Latta, Rachel E AU - Elwy, A Rani AU - Ngo, Tu A AU - Kelly, Megan M AD - Center for Social Innovation, Needham, MA, USA ; Center for Healthcare Organization and Implementation Research, VA Boston Healthcare System, Veterans Health Administration, Bedford, MA, USA; Boston University School of Public Health, Boston, MA, USA ; Edith Nourse Rogers Memorial VA Hospital, Department of Veterans Affairs, Veterans Health Administration, Bedford, MA, USA ; Edith Nourse Rogers Memorial VA Hospital, Department of Veterans Affairs, Veterans Health Administration, Bedford, MA, USA; Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA Y1 - 2016/07// PY - 2016 DA - Jul 2016 SP - 595 EP - 606 CY - New York PB - Springer Science & Business Media VL - 31 IS - 5 SN - 0885-7482 KW - Psychology KW - Domestic violence KW - Women's health KW - Primary care KW - Partner abuse KW - Female veterans KW - Intervention KW - Womens Health Care KW - Health Care Services KW - Health KW - Veterans KW - Diagnosis KW - Females KW - Partner Abuse KW - Tests KW - Screening KW - Violence KW - Selfreport KW - Abusive relationships KW - Feasibility KW - Women's issues KW - 2858:studies in violence; studies in violence KW - 2190:social problems and social welfare; victimology (rape, family violence, & child abuse) KW - 6143:child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1794492397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Violence&rft.atitle=Intimate+Partner+Violence+Screening+in+a+Women+Veterans%27+Health+Clinic%3A+Assessing+Feasibility&rft.au=Latta%2C+Rachel+E%3BElwy%2C+A+Rani%3BNgo%2C+Tu+A%3BKelly%2C+Megan+M&rft.aulast=Latta&rft.aufirst=Rachel&rft.date=2016-07-01&rft.volume=31&rft.issue=5&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Violence&rft.issn=08857482&rft_id=info:doi/10.1007%2Fs10896-016-9798-y LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); Social Services Abstracts; Sociological Abstracts N1 - Name - Department of Veterans Affairs N1 - Copyright - Springer Science+Business Media New York 2016 N1 - Last updated - 2016-09-26 DO - http://dx.doi.org/10.1007/s10896-016-9798-y ER - TY - JOUR T1 - The impact of proposed changes to ICD-11 on estimates of PTSD prevalence and comorbidity. AN - 1792772377; 27124207 AB - The World Health Organization's posttraumatic stress disorder (PTSD) work group has published a proposal for the forthcoming edition of the International Classification of Diseases (ICD-11) that would yield a very different diagnosis relative to DSM-5. This study examined the impact of the proposed ICD-11 changes on PTSD prevalence relative to the ICD-10 and DSM-5 definitions and also evaluated the extent to which these changes would accomplish the stated aim of reducing the comorbidity associated with PTSD. Diagnostic prevalence estimates were compared using a U.S. national community sample and two U.S. Department of Veterans Affairs clinical samples. The ICD-11 definition yielded prevalence estimates 10-30% lower than DSM-5 and 25% and 50% lower than ICD-10 with no reduction in the prevalence of common comorbidities. Findings suggest that by constraining the diagnosis to a narrower set of symptoms, the proposed ICD-11 criteria set would substantially reduce the number of individuals with the disorder. These findings raise doubt about the extent to which the ICD-11 proposal would achieve the aim of reducing comorbidity associated with PTSD and highlight the public health and policy implications of such a redefinition. Published by Elsevier Ireland Ltd. JF - Psychiatry research AU - Wisco, Blair E AU - Miller, Mark W AU - Wolf, Erika J AU - Kilpatrick, Dean AU - Resnick, Heidi S AU - Badour, Christal L AU - Marx, Brian P AU - Keane, Terence M AU - Rosen, Raymond C AU - Friedman, Matthew J AD - Department of Psychology, University of North Carolina at Greensboro, UNCG Psychology, PO Box 26170, Greensboro, NC 27402, USA. Electronic address: bewisco@uncg.edu. ; National Center for PTSD at VA Boston Healthcare System, Department of Psychiatry, Boston University School of Medicine, 150 South Huntington Avenue, Boston, MA 02130, USA. Electronic address: Mark.Miller5@va.gov. ; National Center for PTSD at VA Boston Healthcare System, Department of Psychiatry, Boston University School of Medicine, 150 South Huntington Avenue, Boston, MA 02130, USA. Electronic address: Erika.Wolf@va.gov. ; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina at Charleston, 67 President Stress, MSC 861, Charleston, SC 29425, USA. Electronic address: kilpatdg@musc.edu. ; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina at Charleston, 67 President Stress, MSC 861, Charleston, SC 29425, USA. Electronic address: resnickh@musc.edu. ; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina at Charleston, 67 President Stress, MSC 861, Charleston, SC 29425, USA. Electronic address: christal.badour@uky.edu. ; National Center for PTSD at VA Boston Healthcare System, Department of Psychiatry, Boston University School of Medicine, 150 South Huntington Avenue, Boston, MA 02130, USA. Electronic address: Brian.Marx@va.gov. ; National Center for PTSD at VA Boston Healthcare System, Department of Psychiatry, Boston University School of Medicine, 150 South Huntington Avenue, Boston, MA 02130, USA. Electronic address: Terry.Keane@va.gov. ; New England Research Institutes, 480 Pleasant Street, Watertown, MA 02472, USA. Electronic address: RRosen@neriscience.com. ; VA National Center for PTSD, Departments of Psychiatry and Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, National Center for PTSD, VA Medical Center (116D), 215 North Main Street, White River Junction, VT 05009, USA. Electronic address: matthew.friedman@va.gov. Y1 - 2016/06/30/ PY - 2016 DA - 2016 Jun 30 SP - 226 EP - 233 VL - 240 KW - Index Medicus KW - Diagnostic criteria KW - DSM-5 KW - Diagnosis KW - ICD-11 KW - Trauma KW - PTSD UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1792772377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=The+impact+of+proposed+changes+to+ICD-11+on+estimates+of+PTSD+prevalence+and+comorbidity.&rft.au=Wisco%2C+Blair+E%3BMiller%2C+Mark+W%3BWolf%2C+Erika+J%3BKilpatrick%2C+Dean%3BResnick%2C+Heidi+S%3BBadour%2C+Christal+L%3BMarx%2C+Brian+P%3BKeane%2C+Terence+M%3BRosen%2C+Raymond+C%3BFriedman%2C+Matthew+J&rft.aulast=Wisco&rft.aufirst=Blair&rft.date=2016-06-30&rft.volume=240&rft.issue=&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=1872-7123&rft_id=info:doi/10.1016%2Fj.psychres.2016.04.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-30 N1 - Date revised - 2017-02-02 N1 - SuppNotes - Cited By: Am J Psychiatry. 2001 Jan;158(1):134-6 [11136648] J Consult Clin Psychol. 1998 Dec;66(6):914-23 [9874904] J Trauma Stress. 2013 Oct;26(5):557-9 [24151002] J Trauma Stress. 2013 Oct;26(5):548-56 [24151001] J Trauma Stress. 2013 Oct;26(5):537-47 [24151000] Mol Psychiatry. 2013 Aug;18(8):937-42 [22869035] Lancet. 2013 May 11;381(9878):1683-5 [23583019] Arch Gen Psychiatry. 2012 Jul;69(7):698-705 [22752235] J Trauma Stress. 2009 Oct;22(5):384-90 [19774665] J Trauma Stress. 2009 Oct;22(5):366-73 [19743480] J Trauma Stress. 2010 Oct;23(5):631-8 [20839312] Behav Res Ther. 2010 Sep;48(9):909-14 [20541179] Am J Psychiatry. 2008 Jul;165(7):898-904 [18347001] Psychol Bull. 2007 Sep;133(5):725-46 [17723027] Biol Psychiatry. 2005 May 1;57(9):953-60 [15860334] J Abnorm Psychol. 2004 Nov;113(4):636-45 [15535795] J Trauma Stress. 1999 Apr;12(2):335-43 [10378170] Br J Psychiatry. 1999 Jan;174:3-5 [10211143] Psychol Assess. 2000 Jun;12(2):210-24 [10887767] J Trauma Stress. 2014 Dec;27(6):647-54 [25418442] J Trauma Stress. 1995 Jan;8(1):75-90 [7712061] Br J Psychiatry. 2014 Sep;205(3):230-5 [24809400] N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1016/j.psychres.2016.04.043 ER - TY - JOUR T1 - Prostacyclin reverses the cigarette smoke-induced decrease in pulmonary Frizzled 9 expression through miR-31. AN - 1799560952; 27339092 AB - Half of lung cancers are diagnosed in former smokers, leading to a significant treatment burden in this population. Chemoprevention in former smokers using the prostacyclin analogue iloprost reduces endobronchial dysplasia, a premalignant lung lesion. Iloprost requires the presence of the WNT receptor Frizzled 9 (Fzd9) for inhibition of transformed growth in vitro. To investigate the relationship between iloprost, cigarette smoke, and Fzd9 expression, we used human samples, mouse models, and in vitro studies. Fzd9 expression was low in human lung tumors and in progressive dysplasias. In mouse models and in vitro studies, tobacco smoke carcinogens reduced expression of Fzd9 while prostacyclin maintained or increased expression. Expression of miR-31 repressed Fzd9 expression, which was abrogated by prostacyclin. We propose a model where cigarette smoke exposure increases miR-31 expression, which leads to decreased Fzd9 expression and prevents response to iloprost. When smoke is removed miR-31 is reduced, prostacyclin can increase Fzd9 expression, and progression of dysplasia is inhibited. Fzd9 and miR-31 are candidate biomarkers for precision application of iloprost and monitoring of treatment progress. As we continue to investigate the mechanisms of prostacyclin chemoprevention and identify biomarkers for its use, we will facilitate clinical trials and speed implementation of this valuable prevention approach. JF - Scientific reports AU - Tennis, M A AU - New, M L AU - McArthur, D G AU - Merrick, D T AU - Dwyer-Nield, L D AU - Keith, R L AD - University of Colorado Denver, Aurora, Colorado, USA. ; Denver Veterans Administration Medical Center, Denver, Colorado, USA. Y1 - 2016/06/24/ PY - 2016 DA - 2016 Jun 24 SP - 28519 VL - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1799560952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Prostacyclin+reverses+the+cigarette+smoke-induced+decrease+in+pulmonary+Frizzled+9+expression+through+miR-31.&rft.au=Tennis%2C+M+A%3BNew%2C+M+L%3BMcArthur%2C+D+G%3BMerrick%2C+D+T%3BDwyer-Nield%2C+L+D%3BKeith%2C+R+L&rft.aulast=Tennis&rft.aufirst=M&rft.date=2016-06-24&rft.volume=6&rft.issue=&rft.spage=28519&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep28519 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep28519 ER - TY - JOUR T1 - Electrical stimulation and blood flow restriction increase wrist extensor cross-sectional area and flow meditated dilatation following spinal cord injury AN - 1811886776; PQ0003176098 AB - To examine the effects of neuromuscular electrical stimulation (NMES) and blood flow restricted (BFR) exercise on wrist extensors cross-sectional area (CSA), torque and hand functions compared NMES only in individuals with incomplete tetraplegia. The acute effect of an acute bout of NMES with BFR on flow mediated dilation (FMD) was compared with BFR only. Nine men completed 6 weeks twice weekly of bilateral NMES training of the wrist extensor muscles. The right forearm received NMES + BFR (30 % above the resting systolic blood pressure), while the left forearm received NMES only. The CSA of the extensor carpi radialis longus (ECRL) and extensor digitorum communis (EDC) muscles was measured on ultrasound images. Torque was measured isometrically and hand function with grasp and release test. Another eight men with SCI received NMES+BFR to the right forearm, while the left forearm received BFR only. Immediately, the FMD of the brachial artery was measured. Following training, the ECRL CSA was 17 % greater in the NMES+BFR forearm (mean difference = 0.6 cm super(2), p = 0.003) compared with the NMES only. The NMES+BFR had a 15 % increase in ECRL CSA (mean increase = 0.58 cm super(2) , p = 0.048). FMD increased (p = 0.05) in the exercise arm (12 plus or minus 3 %) compared with the control arm (6.5 plus or minus 6 %). NMES training with BFR is a strategy that can increase skeletal muscle size. NMES with and without BFR can improve wrist strength and hand function. The acute effects of NMES+BFR may suggest that an increase in FMD may partially contribute to skeletal muscle hypertrophy. JF - European Journal of Applied Physiology AU - Gorgey, Ashraf S AU - Timmons, Mark K AU - Dolbow, David R AU - Bengel, Justin AU - Fugate-Laus, Kendall C AU - Michener, Lori A AU - Gater, David R AD - Department of Veterans Affairs, Hunter Holmes McGuire VA Medical Center, Spinal Cord Injury and Disorders Service, 1201 Broad Rock Boulevard, Richmond, VA, 23249, USA, ashraf.gorgey@va.gov Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 1231 EP - 1244 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 116 IS - 6 SN - 1439-6319, 1439-6319 KW - Physical Education Index KW - Hands KW - Force KW - Measurement KW - Blood flow KW - Men KW - Wrists KW - Muscles (growth) KW - Arms KW - Electrical stimulation KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811886776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Applied+Physiology&rft.atitle=Electrical+stimulation+and+blood+flow+restriction+increase+wrist+extensor+cross-sectional+area+and+flow+meditated+dilatation+following+spinal+cord+injury&rft.au=Gorgey%2C+Ashraf+S%3BTimmons%2C+Mark+K%3BDolbow%2C+David+R%3BBengel%2C+Justin%3BFugate-Laus%2C+Kendall+C%3BMichener%2C+Lori+A%3BGater%2C+David+R&rft.aulast=Gorgey&rft.aufirst=Ashraf&rft.date=2016-06-01&rft.volume=116&rft.issue=6&rft.spage=1231&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Applied+Physiology&rft.issn=14396319&rft_id=info:doi/10.1007%2Fs00421-016-3385-z LA - English DB - Physical Education Index N1 - Date revised - 2016-08-01 N1 - Number of references - 43 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Force; Hands; Measurement; Men; Blood flow; Muscles (growth); Wrists; Electrical stimulation; Arms DO - http://dx.doi.org/10.1007/s00421-016-3385-z ER - TY - JOUR T1 - Diabetes Transition Care From an Inpatient to Outpatient Setting in a Veteran Population: Quality Improvement Pilot Study AN - 1811886682; PQ0003146622 AB - Purpose The purpose of the study was to evaluate a diabetes transition care program in a population of veterans with diabetes by calculating 30-day readmission rates and assessing glycemic control. Methods Hospitalized patients with poorly controlled diabetes were identified to participate in the diabetes transition care program. The program included follow-up through a postdischarge telephone call by the diabetes educator, with an opportunity for a face-to-face clinic visit. A retrospective before-and-after study design was used. Analysis included calculating the readmission rate and the pre- and postintervention A1C rates to evaluate the intervention. Results Of the 40 participants, 100% completed the intervention. All 40 participants received a postdischarge telephone call as follow-up, with 20% presenting for a face-to-face visit. The 30-day readmission rate for the cohort was 10%, in comparison to 14.3% for patients who did not receive the intervention but were otherwise comparable. For those who had repeat A1C measurements conducted 2 to 8 months after time of enrollment in the program (n= 33), average A1C declined -2.2%, from 11.3% (100mmol/mol) to 9.1% (76 mmol/mol). Conclusions Diabetes-specific transition of care for those with complex psychiatric, medical, and social needs was feasible, with good outcomes in hospital readmission rates and glycemic control, when executed by an adult nurse practitioner who was the inpatient diabetes educator. JF - Diabetes Educator AU - Brumm, Susan AU - Theisen, Kathleen AU - Falciglia, Mercedes Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 346 EP - 353 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 42 IS - 3 SN - 0145-7217, 0145-7217 KW - Physical Education Index KW - Measurement KW - Programs KW - Analysis KW - Patients KW - Adults KW - Diabetes KW - Hospitals KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811886682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+Educator&rft.atitle=Diabetes+Transition+Care+From+an+Inpatient+to+Outpatient+Setting+in+a+Veteran+Population%3A+Quality+Improvement+Pilot+Study&rft.au=Brumm%2C+Susan%3BTheisen%2C+Kathleen%3BFalciglia%2C+Mercedes&rft.aulast=Brumm&rft.aufirst=Susan&rft.date=2016-06-01&rft.volume=42&rft.issue=3&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Diabetes+Educator&rft.issn=01457217&rft_id=info:doi/10.1177%2F0145721716642020 LA - English DB - Physical Education Index N1 - Date revised - 2016-08-01 N1 - Number of references - 25 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Measurement; Programs; Analysis; Patients; Adults; Hospitals; Diabetes DO - http://dx.doi.org/10.1177/0145721716642020 ER - TY - JOUR T1 - The effect of long and short head biceps loading on glenohumeral joint rotational range of motion and humeral head position AN - 1808729642; PQ0003235897 AB - Purpose: To evaluate the effect of loading the long and short heads of the biceps on glenohumeral range of motion and humeral head position. Methods: Eight cadaveric shoulders were tested in 60 degree abduction in the scapula and coronal plane. Muscle loading was applied based on cross-sectional area ratios. The short and long head of the biceps were loaded individually followed by combined loading. Range of motion was measured with 2.2 Nm torque, and the humeral head apex position was measured using a MicroScribe. A paired t test with Bonferroni correction was used for statistics. Results: Long head loading decreased internal rotation in both the scapular (17.9 %) and coronal planes (5.7 %) and external rotation in the scapular plane (2.6 %) (P < 0.04). With only short head loading, maximum internal rotation was significantly increased in the scapular and coronal plane. Long head and short head loading shifted the humeral head apex posteriorly in maximum internal rotation in both planes with the long head shift being significantly greater than the short head. Long head loading also shifted the humeral apex inferiorly in internal rotation and inferiorly posteriorly in neutral rotation in the scapular plane. With the long head unloaded, there was a significant superior shift with short head loading in both planes. Conclusion: Loading the long head of the biceps had a much greater effect on glenohumeral range of motion and humeral head shift than the short head of the biceps; however, in the absence of long head loading, with the short head loaded, maximum internal rotation increases and the humeral head shifts superiorly, which may contribute to impingement following tenodesis of the long head of the biceps. These small changes in rotational range of motion and humeral head position with biceps tenodesis may not lead to pathologic conditions in low-demand patients; however, in throwers, biceps tenodesis may lead to increased contact pressures in late-cocking and deceleration that will likely translate to decreased performance therefore every effort should be made to preserve the biceps-labral complex. JF - Knee Surgery, Sports Traumatology, Arthroscopy AU - McGarry, Michelle H AU - Nguyen, Michael L AU - Quigley, Ryan J AU - Hanypsiak, Bryan AU - Gupta, Ranjan AU - Lee, Thay Q AD - Orthopaedic Biomechanics Laboratory, VA Long Beach Healthcare System (09/151), 5901 East 7th. Street, Long Beach, CA, 90822, USA, tqlee@va.gov Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 1979 EP - 1987 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 24 IS - 6 SN - 0942-2056, 0942-2056 KW - Biotechnology and Bioengineering Abstracts; Physical Education Index KW - Measurement KW - Scapula KW - Statistics KW - Head KW - Humerus KW - Flexibility KW - Muscles KW - Sports KW - Knee KW - Joints KW - arthroscopy KW - Shoulder KW - Surgery KW - Cadavers KW - Shoulders KW - Performance KW - Pressure KW - PE 090:Sports Medicine & Exercise Sport Science KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808729642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.atitle=The+effect+of+long+and+short+head+biceps+loading+on+glenohumeral+joint+rotational+range+of+motion+and+humeral+head+position&rft.au=McGarry%2C+Michelle+H%3BNguyen%2C+Michael+L%3BQuigley%2C+Ryan+J%3BHanypsiak%2C+Bryan%3BGupta%2C+Ranjan%3BLee%2C+Thay+Q&rft.aulast=McGarry&rft.aufirst=Michelle&rft.date=2016-06-01&rft.volume=24&rft.issue=6&rft.spage=1979&rft.isbn=&rft.btitle=&rft.title=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.issn=09422056&rft_id=info:doi/10.1007%2Fs00167-014-3318-5 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 31 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Measurement; Statistics; Head; Surgery; Flexibility; Muscles; Shoulders; Performance; Sports; Scapula; arthroscopy; Shoulder; Humerus; Cadavers; Pressure; Knee; Joints DO - http://dx.doi.org/10.1007/s00167-014-3318-5 ER - TY - JOUR T1 - A biomechanical assessment of a novel double endobutton technique versus a coracoid cerclage sling for acromioclavicular and coracoclavicular injuries AN - 1808722987; PQ0003235876 AB - Purpose: Recently, many acromioclavicular-coracoclavicular (AC-CC) ligament reconstruction techniques address only the CC ligament. However, many of these techniques are costly, time-consuming, and require the use of allogenic grafts, making them prone to creep and failure or novel devices making them challenging for orthopaedic surgeons. The purpose of this study was to compare the biomechanical characteristics of a double endobutton technique using a standard endobutton CL with those of a coracoid cerclage sling (CS) for reconstruction of the CC ligaments. Methods: Anterior-posterior (AP) translation and superior-inferior (SI) translation were quantified for eight matched pairs of intact AC joints. One shoulder from each pair underwent a double endobutton repair, using an endobutton CL modified with an additional endobutton (Smith & Nephew, Memphis, Tenn) and placed through holes in the coracoid and clavicle. The contra-lateral shoulder received a coracoid sling reconstruction using an anterior tibialis tendon. Translation testing was repeated after reconstruction, followed by load-to-failure testing. Paired t tests were used for statistical analysis. Results: The CS technique demonstrated a greater SI and AP translation than the double endobutton technique (p < 0.05). Additionally, the double endobutton technique had a greater stiffness (40.2 plus or minus 11.0 vs. 20.3 plus or minus 6.4 N/mm, p = 0.005), yield load (168.5 plus or minus 11.0 vs. 86.8 plus or minus 22.9 N, p = 0.002), and ultimate load (504.4 plus or minus 199.7 vs. 213.2 plus or minus 103.4 N, p = 0.026) when compared to the CS technique. Conclusion: The double endobutton technique yielded less translation about the AC joint and displayed stronger load-to-failure characteristics than the CS reconstruction. As such, this technique may be better suited to restore native AC-CC biomechanics, reduce post-operative pain, and prevent recurrent subluxation and dislocation than an allogenic graft construct. The double endobutton technique may be a suitable option for addressing AC-CC injuries. JF - Knee Surgery, Sports Traumatology, Arthroscopy AU - Grantham, Cori AU - Heckmann, Nathanael AU - Wang, Lawrence AU - Tibone, James E AU - Struhl, Steven AU - Lee, Thay Q AD - Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, tqlee@va.gov Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 1918 EP - 1924 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 24 IS - 6 SN - 0942-2056, 0942-2056 KW - Biotechnology and Bioengineering Abstracts; Physical Education Index KW - Translation KW - Injuries KW - Reconstruction KW - Dislocations KW - Statistical analysis KW - Techniques KW - Pain KW - arthroscopy KW - Shoulder KW - Surgery KW - Biomechanics (sports techniques) KW - Adenylate cyclase KW - Clavicle KW - Ligaments KW - Knee KW - Joints KW - Dislocation KW - Shoulders KW - Work load KW - Tendons KW - Biomechanics KW - PE 090:Sports Medicine & Exercise Sport Science KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808722987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.atitle=A+biomechanical+assessment+of+a+novel+double+endobutton+technique+versus+a+coracoid+cerclage+sling+for+acromioclavicular+and+coracoclavicular+injuries&rft.au=Grantham%2C+Cori%3BHeckmann%2C+Nathanael%3BWang%2C+Lawrence%3BTibone%2C+James+E%3BStruhl%2C+Steven%3BLee%2C+Thay+Q&rft.aulast=Grantham&rft.aufirst=Cori&rft.date=2016-06-01&rft.volume=24&rft.issue=6&rft.spage=1918&rft.isbn=&rft.btitle=&rft.title=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.issn=09422056&rft_id=info:doi/10.1007%2Fs00167-014-3198-8 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 27 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Ligaments; Dislocations; Surgery; Techniques; Work load; Shoulders; Biomechanics (sports techniques); Biomechanics; Joints; Clavicle; Translation; Reconstruction; Injuries; Statistical analysis; Pain; Knee; Dislocation; arthroscopy; Shoulder; Tendons; Adenylate cyclase DO - http://dx.doi.org/10.1007/s00167-014-3198-8 ER - TY - JOUR T1 - Pitfalls and Pearls of Wisdom in 18F-FDG PET Imaging of Tumors AN - 1808718223; PQ0003241407 AB - 18F-FDG PET imaging of tumors has pitfalls and pearls of wisdom that begin at the point of scheduling and continue through the patient interview, the resting phase, the scan itself, and the image review. Interviewing the patient at the time of scheduling, followed by placing a reminder phone call shortly before the appointment, can save a nuclear medicine department the financial loss of wasted doses and missed appointment slots in the schedule. The pitfalls and pearls of wisdom in tumor imaging are ever changing, and the technologist is in a constant state of inquiry about the patient's disease process and ability to comply. Consideration of each item on the worksheets in this article affects every scan. On completing this article, the reader will be able to identify questions that should be asked in the scheduling and preinjection patient interviews, interpret the answers to those questions, determine how the images may be affected, and adapt the scan. JF - Journal of Nuclear Medicine Technology AU - Britton, Tracey AU - Robinson, Nicholas AD - Nuclear Medicine Service, Birmingham Veterans Administration Medical Center, Birmingham, Alabama; and Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 59 EP - 64 PB - Society of Nuclear Medicine VL - 44 IS - 2 SN - 0091-4916, 0091-4916 KW - Biotechnology and Bioengineering Abstracts KW - interview KW - question KW - review KW - adapt KW - assess KW - Pearls KW - Reviews KW - Positron emission tomography KW - Reminder KW - Nuclear medicine KW - Tumors KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808718223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nuclear+Medicine+Technology&rft.atitle=Pitfalls+and+Pearls+of+Wisdom+in+18F-FDG+PET+Imaging+of+Tumors&rft.au=Britton%2C+Tracey%3BRobinson%2C+Nicholas&rft.aulast=Britton&rft.aufirst=Tracey&rft.date=2016-06-01&rft.volume=44&rft.issue=2&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nuclear+Medicine+Technology&rft.issn=00914916&rft_id=info:doi/10.2967%2Fjnmt.115.170803 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Pearls; Reviews; Reminder; Positron emission tomography; Nuclear medicine; Tumors DO - http://dx.doi.org/10.2967/jnmt.115.170803 ER - TY - JOUR T1 - Associations between markers of colorectal cancer stem cells, mutation, microRNA and the clinical features of ulcerative colitis. AN - 1795865140; 27153478 AB - AIM Several factors have been implicated in the pathogenesis of colorectal cancer (CRC) associated with ulcerative colitis (UC). We investigated markers of cancer cell pluripotency, including CD44 and CD166, microRNA-21 (miR-21) and microRNA-215 (miR-215), and APC, K-ras and DCC mutations in biopsy specimens from patients with UC to evaluate any correlations with clinical risk factors. METHOD We observed 18 patients with UC and collected two biopsy specimens from each patient at diagnosis and at a follow-up end-point. We examined the expression of CD44, CD166, miR-21 and miR-215, and APC, K-ras and DCC mutations. We compared these markers at the two time points and assessed their associations with clinical characteristics, including the duration of colitis, histological alterations and the age of the patient at the onset of UC. RESULTS Most (16/18) patients had alleviation of mucosal inflammation or remained stable during follow-up; one patient developed dysplasia and one had severe aggravation of the lesion during follow-up. Enhanced expression of CD44, CD166 and miR-21 with miR-215 was found in the specimens obtained at follow-up, despite alleviation of mucosal lesions. Coherence of cancer stem cell markers and miRNAs was seen in patients who had significant worsening of inflammation, dysplasia and a long duration of colitis. APC mutation occurred in only one patient; this patient had the longest duration of UC (23 years). CONCLUSION Enhanced markers of CRC in follow-up colonic mucosal samples support the conclusion that the duration of UC plays the most important role in UC-related carcinogenesis. JF - Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland AU - Yang, L AU - Levi, E AU - Du, J H AU - Zhou, H H AU - Miller, R AU - Majumdar, A P N AD - Department of Gastroenterology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China. ; Division of Gastroenterology and Department of Internal Medicine, Veterans Administration Medical Center, Detroit, Michigan, USA. ; Department of Pathology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - O185 EP - O193 VL - 18 IS - 6 KW - Index Medicus KW - APC mutation KW - miR-21 KW - carcinogenesis KW - Ulcerative colitis KW - colorectal cancer KW - cancer stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795865140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Colorectal+disease+%3A+the+official+journal+of+the+Association+of+Coloproctology+of+Great+Britain+and+Ireland&rft.atitle=Associations+between+markers+of+colorectal+cancer+stem+cells%2C+mutation%2C+microRNA+and+the+clinical+features+of+ulcerative+colitis.&rft.au=Yang%2C+L%3BLevi%2C+E%3BDu%2C+J+H%3BZhou%2C+H+H%3BMiller%2C+R%3BMajumdar%2C+A+P+N&rft.aulast=Yang&rft.aufirst=L&rft.date=2016-06-01&rft.volume=18&rft.issue=6&rft.spage=O185&rft.isbn=&rft.btitle=&rft.title=Colorectal+disease+%3A+the+official+journal+of+the+Association+of+Coloproctology+of+Great+Britain+and+Ireland&rft.issn=1463-1318&rft_id=info:doi/10.1111%2Fcodi.13371 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-09 N1 - Date revised - 2017-02-09 N1 - Last updated - 2017-02-09 DO - http://dx.doi.org/10.1111/codi.13371 ER - TY - JOUR T1 - Alcoholic Liver Disease in Asia, Europe, and North America. AN - 1793212934; 26924091 AB - Alcoholic liver diseases comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis. Although the relationship between alcohol consumption and liver disease is well established, severe alcohol-related morbidities develop in only a minority of people who consume alcohol in excess. Inter-individual differences in susceptibility to the toxic effects of alcohol have been studied extensively-they include pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. Alcoholic liver disease is becoming more common in many parts of Asia, but is decreasing in Western Europe. Treatment approaches, including availability of medications, models of care, and approach to transplantation, differ among regions. Copyright © 2016 AGA Institute. Published by Elsevier Inc. All rights reserved. JF - Gastroenterology AU - Liangpunsakul, Suthat AU - Haber, Paul AU - McCaughan, Geoffrey W AD - Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Roudebush Veterans Administration Medical Center, Indianapolis, Indiana. Electronic address: sliangpu@iupui.edu. ; Drug Health Services, Royal Prince Alfred Hospital, Sydney Medical School, University of Sydney, Australia. ; Centenary Research Institute, AW Morrow GE/Liver Center Australian Liver Transplant Unit Royal Prince Alfred Hospital, University of Sydney, Australia. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 1786 EP - 1797 VL - 150 IS - 8 KW - Abridged Index Medicus KW - Index Medicus KW - North America KW - Clinical Profiles KW - Europe KW - Asia KW - Alcoholic Liver Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793212934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Alcoholic+Liver+Disease+in+Asia%2C+Europe%2C+and+North+America.&rft.au=Liangpunsakul%2C+Suthat%3BHaber%2C+Paul%3BMcCaughan%2C+Geoffrey+W&rft.aulast=Liangpunsakul&rft.aufirst=Suthat&rft.date=2016-06-01&rft.volume=150&rft.issue=8&rft.spage=1786&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=1528-0012&rft_id=info:doi/10.1053%2Fj.gastro.2016.02.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-31 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Addiction. 2014 Jun;109(6):880-93 [24467748] Kaohsiung J Med Sci. 2014 Jun;30(6):291-8 [24835349] Lancet. 1995 Oct 14;346(8981):987-90 [7475591] Alcohol Alcohol Suppl. 1994;2:21-7 [8974312] Hepatology. 1997 Jan;25(1):108-11 [8985274] Gut. 1997 Dec;41(6):845-50 [9462221] Dig Dis Sci. 2014 Dec;59(12):2967-74 [25069572] Hepatology. 2014 Dec;60(6):2099-108 [25164003] Lancet. 2014 Nov 29;384(9958):1953-97 [25433429] Public Health. 2014 Nov;128(11):977-84 [25443132] Addiction. 2015 Jan;110(1):59-68 [25138287] Addiction. 2015 Jan;110 Suppl 1:68-78 [25533866] Alcohol Clin Exp Res. 2015 Mar;39(3):522-31 [25704494] Lancet Glob Health. 2015 Apr;3(4):e190-1 [25794669] J Hepatol. 2015 May;62(5):1061-7 [25634330] J Hepatol. 2015 Apr;62(1 Suppl):S38-46 [25920088] J Clin Gastroenterol. 2015 Jul;49(6):506-11 [25198164] Am J Public Health. 2015 Nov;105(11):2220-7 [26378848] Nat Genet. 2015 Dec;47(12):1443-8 [26482880] Clin Gastroenterol Hepatol. 2016 Feb;14(2):191-202.e1-4; 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Data Sources Data came from the 2010 Medicare CAHPS survey, to which 220,040 MA and 135,874 FFS enrollees aged 65 and older responded. Study Design Multivariate linear regression was used to test whether case-mix-adjusted associations between depressive symptoms and patient experience differed for beneficiaries in MA versus FFS. Dependent measures included four measures of beneficiaries' experiences with doctors (e.g., reports of doctor communication) and seven measures of beneficiaries' experiences with plans (e.g., customer service). Principal Findings Beneficiaries with depressive symptoms reported worse experiences than those without depressive symptoms regardless of coverage type. For measures assessing interactions with the plan (but not for measures assessing interactions with doctors), the disadvantage for beneficiaries with versus without depressive symptoms was larger in MA than in FFS. Conclusions Disparities in care experienced by older Medicare beneficiaries with depressive symptoms tend to be more negative in managed care than in FFS. Efforts are needed to identify and address the barriers these beneficiaries encounter to help them better traverse the managed care environment. JF - Health Services Research AU - Martino, Steven C AU - Elliott, Marc N AU - Haviland, Amelia M AU - Saliba, Debra AU - Burkhart, Q AU - Kanouse, David E AD - RAND Corporation, Pittsburgh, PA ; RAND Corporation, Santa Monica, CA ; Heinz College, Carnegie Mellon University, Pittsburgh, PA ; UCLA, JH Borun Center and Los Angeles Veterans Administration Health System, Los Angeles, CA Y1 - 2016/06// PY - 2016 DA - Jun 2016 SP - 1002 EP - 1020 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 51 IS - 3 SN - 0017-9124 KW - Medical Sciences KW - Beneficiaries KW - Coverage KW - Depression KW - Doctor-Patient communication KW - Health inequalities KW - In care KW - Managed care KW - Medicare KW - Older people KW - Quality of service UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790472904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consumer+Health+on+the+Internet&rft.atitle=Influenza+A+%28H1N1%29+Virus+%28Swine+Influenza%29%3A+A+Webliography&rft.au=Taylor%2C+Mary+Virginia%3BStephenson%2C+Priscilla+L&rft.aulast=Taylor&rft.aufirst=Mary&rft.date=2009-10-01&rft.volume=13&rft.issue=4&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consumer+Health+on+the+Internet&rft.issn=15398285&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2016-05-25 DO - http://dx.doi.org/10.1111/1475-6773.12359 ER - TY - JOUR T1 - Using Social Media, Online Social Networks, and Internet Search as Platforms for Public Health Interventions: A Pilot Study AN - 1790472853 AB - Objective To pilot public health interventions at women potentially interested in maternity care via campaigns on social media (Twitter), social networks (Facebook), and online search engines (Google Search). Data Sources/Study Setting Primary data from Twitter, Facebook, and Google Search on users of these platforms in Los Angeles between March and July 2014. Study Design Observational study measuring the responses of targeted users of Twitter, Facebook, and Google Search exposed to our sponsored messages soliciting them to start an engagement process by clicking through to a study website containing information on maternity care quality information for the Los Angeles market. Principal Findings Campaigns reached a little more than 140,000 consumers each day across the three platforms, with a little more than 400 engagements each day. Facebook and Google search had broader reach, better engagement rates, and lower costs than Twitter. Costs to reach 1,000 targeted users were approximately in the same range as less well-targeted radio and TV advertisements, while initial engagements--a user clicking through an advertisement--cost less than $1 each. Conclusions Our results suggest that commercially available online advertising platforms in wide use by other industries could play a role in targeted public health interventions. JF - Health Services Research AU - Huesch, Marco D AU - Galstyan, Aram AU - Ong, Michael K AU - Doctor, Jason N AD - USC Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles, CA ; Information Sciences Institute, University of Southern California, Marina del Rey, CA; Department of Computer Science, Viterbi School of Engineering, University of Southern California, Marina del Rey, CA ; Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at the University of California, Los Angeles, CA; Veterans Administration Los Angeles, Los Angeles, CA ; USC Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles, CA; School of Pharmacy, University of Southern California, Los Angeles, CA Y1 - 2016/06// PY - 2016 DA - Jun 2016 SP - 1273 EP - 1290 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 51 IS - S2 SN - 0017-9124 KW - Medical Sciences KW - Advertisements KW - Advertising KW - Campaigns KW - Consumers KW - Health costs KW - Health education KW - Health status KW - Interventions KW - Public health KW - Quality of care KW - Radio KW - Search engines KW - Social networks KW - Soliciting KW - Women's issues KW - Los Angeles California UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790472853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Using+Social+Media%2C+Online+Social+Networks%2C+and+Internet+Search+as+Platforms+for+Public+Health+Interventions%3A+A+Pilot+Study&rft.au=Huesch%2C+Marco+D%3BGalstyan%2C+Aram%3BOng%2C+Michael+K%3BDoctor%2C+Jason+N&rft.aulast=Huesch&rft.aufirst=Marco&rft.date=2016-06-01&rft.volume=51&rft.issue=S2&rft.spage=1273&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12496 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Facebook Inc; Google Inc; Twitter Inc N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2016-05-25 N1 - SubjectsTermNotLitGenreText - Los Angeles California DO - http://dx.doi.org/10.1111/1475-6773.12496 ER - TY - JOUR T1 - Prevalence and incidence of liver enzyme elevations in a pooled oncology clinical trial cohort. AN - 1790454585; 27025923 AB - Few epidemiologic studies describe longitudinal liver chemistry (LC) elevations in cancer patients. A population-based retrospective cohort was identified from 31 Phase 2-3 oncology trials (excluding targeted therapies) conducted from 1985 to 2005 to evaluate background rates of LC elevations in patients (n = 3998) with or without liver metastases. Patients with baseline liver metastases (29% of patients) presented with a 3% prevalence of alanine transaminase (ALT) ≥ 3x upper limits normal (ULN) and 0.2% prevalence of bilirubin ≥ 3xULN. During follow-up, the incidence (per 1000 person-months) of new onset ALT elevations ≥3xULN was 6.1 (95% CI: 4.5, 8.0) and 2.2 (95% CI: 0.9, 4.5) in patients without and with liver metastases, respectively. No new incident cases of ALT and bilirubin elevations suggestive of severe liver injury occurred among those with liver metastases; a single case occurred among those without metastasis. Regardless of the presence of liver metastases, LC elevations were rare in cancer patients during oncology trials, which may be due to enrollment criteria. Our study validates uniform thresholds for detection of LC elevations in oncology studies and serves as an empirical referent point for comparing liver enzyme abnormalities in oncology trials of novel targeted therapies. These data support uniform LC stopping criteria in oncology trials. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Shantakumar, Sumitra AU - Landis, Sarah AU - Lawton, Andy AU - Hunt, Christine M AD - Worldwide Epidemiology, GlaxoSmithKline, Gateway West, Singapore. Electronic address: sumitra.y.shantakumar@gsk.com. ; Worldwide Epidemiology, GlaxoSmithKline, Stockley Park, United Kingdom. Electronic address: sarah.h.landis@gsk.com. ; Worldwide Epidemiology, GlaxoSmithKline, Stockley Park, United Kingdom. Electronic address: andy.m.lawton@gsk.com. ; Department of Veterans Affairs, Durham VA Medical Center, North Carolina, USA. Electronic address: christine.hunt@va.gov. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 257 EP - 262 VL - 77 KW - Index Medicus KW - Liver injury KW - Liver enzyme KW - Truncated robust multivariate outlier detection KW - Oncology KW - Bilirubin KW - Alanine aminotransferase KW - Hepatotoxicity KW - Metastasis KW - Clinical trial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790454585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Prevalence+and+incidence+of+liver+enzyme+elevations+in+a+pooled+oncology+clinical+trial+cohort.&rft.au=Shantakumar%2C+Sumitra%3BLandis%2C+Sarah%3BLawton%2C+Andy%3BHunt%2C+Christine+M&rft.aulast=Shantakumar&rft.aufirst=Sumitra&rft.date=2016-06-01&rft.volume=77&rft.issue=&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.03.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.03.019 ER - TY - JOUR T1 - Sleep Quality Improvement During Cognitive Behavioral Therapy for Anxiety Disorders AN - 1789436495 AB - Despite the ubiquity of sleep complaints among individuals with anxiety disorders, few prior studies have examined whether sleep quality improves during anxiety treatment. The current study examined pre- to posttreatment sleep quality improvement during cognitive behavioral therapy (CBT) for panic disorder (PD; [Formula omitted.] ) or generalized anxiety disorder (GAD; [Formula omitted.] ). Among sleep quality indices, only global sleep quality and sleep latency improved significantly (but modestly) during CBT. Sleep quality improvement was greater for treatment responders, but did not vary by diagnosis. Additionally, poor baseline sleep quality was independently associated with worse anxiety treatment outcome, as measured by higher intolerance of uncertainty. Additional intervention targeting sleep prior to or during CBT for anxiety may be beneficial for poor sleepers. JF - Behavioral Sleep Medicine AU - Ramsawh, Holly J AU - Bomyea, Jessica AU - Stein, Murray B AU - Cissell, Shadha H AU - Lang, Ariel J AD - Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences ; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology ; Department of Psychiatry, University of California San Diego; Department of Family & Preventive Medicine, University of California San Diego ; Department of Psychiatry, University of California San Diego ; Veterans Administration San Diego Health Care System, Center of Excellence for Stress and Mental Health; Department of Psychiatry, University of California San Diego Y1 - 2016///May/Jun PY - 2016 DA - May/Jun 2016 SP - 267 EP - 278 CY - Mahwah PB - Taylor & Francis Ltd. VL - 14 IS - 3 SN - 1540-2002 KW - Psychology KW - Sleep KW - Cognitive behaviour therapy KW - Generalized anxiety disorders KW - Quality management KW - Sleep problems KW - Anxieties KW - Insomnia KW - Behavior modification KW - Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1789436495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sleep+Medicine&rft.atitle=Sleep+Quality+Improvement+During+Cognitive+Behavioral+Therapy+for+Anxiety+Disorders&rft.au=Ramsawh%2C+Holly+J%3BBomyea%2C+Jessica%3BStein%2C+Murray+B%3BCissell%2C+Shadha+H%3BLang%2C+Ariel+J&rft.aulast=Ramsawh&rft.aufirst=Holly&rft.date=2016-05-01&rft.volume=14&rft.issue=3&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sleep+Medicine&rft.issn=15402002&rft_id=info:doi/10.1080%2F15402002.2014.981819 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright © Taylor & Francis Group, LLC N1 - Last updated - 2016-05-19 DO - http://dx.doi.org/10.1080/15402002.2014.981819 ER - TY - JOUR T1 - Changes in Sleep with Auricular Point Acupressure for Chronic Low Back Pain AN - 1789436226 AB - The purpose of this study was to report sleep quality from 4 weeks of auricular point acupressure that was designed for chronic low back pain and determine the relationship between pain intensity and sleep quality. Participants were randomized into the APA group [Formula omitted.] or the sham-APA group [Formula omitted.] . At baseline assessment, 87% of the participants reported poor sleep quality. Participants who received APA had decreased daytime disturbance and improved global Pittsburgh Sleep Quality Index scores at end of intervention (EOI) and 1-month follow up compared to participants in the sham-APA group. For the APA group, both the sleep duration and wake after sleep onset decreased gradually during the 4-week APA (0.56% and 0.23% daily change, respectively). JF - Behavioral Sleep Medicine AU - Yeh, Chao Hsing AU - Suen, Lorna Kwai-Ping AU - Shen, Juan AU - Chien, Lung-Chang AU - Liang, Zhan AU - Glick, Ronald M AU - Morone, Natalia E AU - Chasens, Eileen R AD - School of Nursing, University of Pittsburgh ; School of Nursing, Hong Kong Polytechnic University ; School of Nursing, Suzhou Health College ; Department of Biostatistics, University of Texas School of Public Health at San Antonio Regional Campus; Research to Advance Community Health Center, University of Texas Health Science Center at San Antonio Regional Campus ; Departments of Psychiatry, Physical Medicine, and Rehabilitation, University of Pittsburgh, School of Medicine ; Department of Medicine, Division of General Internal Medicine, University of Pittsburgh, School of Medicine; Veterans Administration Pittsburgh Healthcare System, Geriatric Research, Education, and Clinical Center Y1 - 2016///May/Jun PY - 2016 DA - May/Jun 2016 SP - 279 EP - 294 CY - Mahwah PB - Taylor & Francis Ltd. VL - 14 IS - 3 SN - 1540-2002 KW - Psychology KW - Sleep KW - Acupressure KW - Chronic low back pain KW - Sleep problems KW - Insomnia KW - Back pain KW - Quality KW - Pittsburgh Pennsylvania UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1789436226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sleep+Medicine&rft.atitle=Changes+in+Sleep+with+Auricular+Point+Acupressure+for+Chronic+Low+Back+Pain&rft.au=Yeh%2C+Chao+Hsing%3BSuen%2C+Lorna+Kwai-Ping%3BShen%2C+Juan%3BChien%2C+Lung-Chang%3BLiang%2C+Zhan%3BGlick%2C+Ronald+M%3BMorone%2C+Natalia+E%3BChasens%2C+Eileen+R&rft.aulast=Yeh&rft.aufirst=Chao&rft.date=2016-05-01&rft.volume=14&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sleep+Medicine&rft.issn=15402002&rft_id=info:doi/10.1080%2F15402002.2014.981820 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright © Taylor & Francis Group, LLC N1 - Last updated - 2016-05-19 N1 - SubjectsTermNotLitGenreText - Pittsburgh Pennsylvania DO - http://dx.doi.org/10.1080/15402002.2014.981820 ER - TY - JOUR T1 - Kidney injury molecule-1 (KIM-1) mediates renal epithelial cell repair via ERK MAPK signaling pathway. AN - 1788228790; 27084535 AB - The expression of kidney injury molecule-1 (KIM-1), a very promising sensitive and specific urinary biomarker for acute renal injury, is markedly upregulated in injured and regenerating renal proximal tubular epithelial cells following ischemic or toxic insults, suggesting a possible role for this molecule in renal repair process. In the present study, we report that expression of KIM-1 facilitates renal tubular epithelial cell repair by promoting cell migration and proliferation. KIM-1 expression also enhances ERK MAPK activation, and the modulatory effect of KIM-1 on cellular repair process is likely mediated via ERK MAPK signaling pathway. JF - Molecular and cellular biochemistry AU - Zhang, Zhiwei AU - Cai, Cindy X AD - Division of Nephrology, Department of Medicine, VA Loma Linda Healthcare System (111 N) and Loma Linda University School of Medicine, 11201 Benton Street, Loma Linda, CA, 92357, USA. zhiwei.zhang@va.gov. ; Division of Gastroenterology, Department of Medicine, VA Loma Linda Healthcare System and Loma Linda University School of Medicine, Loma Linda, CA, USA. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 109 EP - 116 VL - 416 IS - 1-2 KW - HAVCR1 protein, human KW - 0 KW - Hepatitis A Virus Cellular Receptor 1 KW - Index Medicus KW - ERK MAPK KW - Cellular repair KW - Cell migration KW - Cell proliferation KW - Kidney injury molecule-1 (KIM-1) KW - Humans KW - Cell Line KW - Epithelial Cells -- metabolism KW - Cell Movement KW - MAP Kinase Signaling System KW - Kidney Tubules, Proximal -- metabolism KW - Epithelial Cells -- pathology KW - Kidney Tubules, Proximal -- pathology KW - Hepatitis A Virus Cellular Receptor 1 -- genetics KW - Cell Proliferation KW - Hepatitis A Virus Cellular Receptor 1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1788228790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biochemistry&rft.atitle=Kidney+injury+molecule-1+%28KIM-1%29+mediates+renal+epithelial+cell+repair+via+ERK+MAPK+signaling+pathway.&rft.au=Zhang%2C+Zhiwei%3BCai%2C+Cindy+X&rft.aulast=Zhang&rft.aufirst=Zhiwei&rft.date=2016-05-01&rft.volume=416&rft.issue=1-2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biochemistry&rft.issn=1573-4919&rft_id=info:doi/10.1007%2Fs11010-016-2700-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-02-06 N1 - Date created - 2016-05-10 N1 - Date revised - 2017-02-08 N1 - SuppNotes - Cited By: Cell. 1996 Feb 9;84(3):359-69 [8608589] N Engl J Med. 1996 May 30;334(22):1448-60 [8618585] J Biol Chem. 1998 Feb 13;273(7):4135-42 [9461608] J Virol. 1998 Aug;72(8):6621-8 [9658108] J Clin Invest. 2005 Jul;115(7):1743-55 [16007251] Kidney Int. 2005 Oct;68(4):1613-7 [16164638] Kidney Int. 2005 Nov;68(5):1956-61 [16221175] J Am Soc Nephrol. 2007 Mar;18(3):904-12 [17267747] J Am Soc Nephrol. 2007 Oct;18(10):2704-14 [17898236] Kidney Int. 2008 Apr;73(7):863-9 [18059454] Cell Stem Cell. 2008 Mar 6;2(3):284-91 [18371453] Clin J Am Soc Nephrol. 2008 May;3(3):844-61 [18337550] J Clin Invest. 2008 May;118(5):1657-68 [18414680] Nat Biotechnol. 2010 May;28(5):478-85 [20458318] Kidney Int. 2010 Nov;78(9):838-48 [20703216] J Clin Invest. 2011 Nov;121(11):4210-21 [22045571] J Clin Invest. 2015 Apr;125(4):1620-36 [25751064] Am J Pathol. 2015 May;185(5):1207-15 [25759266] Am J Physiol Renal Physiol. 2005 Jul;289(1):F31-42 [15713913] Am J Physiol Renal Physiol. 2000 Oct;279(4):F593-604 [10997909] Nat Immunol. 2001 Dec;2(12):1109-16 [11725301] Cell Res. 2002 Mar;12(1):9-18 [11942415] Kidney Int. 2002 Jul;62(1):237-44 [12081583] J Biol Chem. 2002 Oct 18;277(42):39739-48 [12138159] J Am Soc Nephrol. 2003 May;14(5):1188-99 [12707389] J Am Soc Nephrol. 2003 Jun;14 Suppl 1:S55-61 [12761240] J Clin Invest. 2003 Jul;112(1):42-9 [12824456] Am J Physiol Renal Physiol. 2004 Mar;286(3):F552-63 [14600030] Curr Biol. 2004 Apr 20;14(8):731-5 [15084290] Mol Endocrinol. 1992 May;6(5):845-54 [1603090] Eur J Cell Biol. 1995 Sep;68(1):1-7 [8549585] N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1007/s11010-016-2700-7 ER - TY - JOUR T1 - Effectiveness of individualized, integrative outpatient treatment for females with anorexia nervosa and bulimia nervosa AN - 1786270411 AB - The effectiveness of an individualized outpatient program was investigated in the treatment of bulimia nervosa (BN) and anorexia nervosa (AN). Participants included 151 females who received outpatient eating disorder treatment in the partial hospitalization program, the intensive outpatient program, or a combination of the two programs. Outcome measures included the Eating Disorder Inventory (EDI-2), Beck Depression Inventory (BDI-II), frequency of binge eating and purging, and mean body weight. Findings included significant increases in weight for the AN group, reductions in binge eating frequency for the BN group, and reductions in EDI-2 and BDI-II scores and purging frequency for both groups. This study provides preliminary support for the efficacy of a multimodal program for the treatment of both anorexia nervosa and bulimia nervosa. JF - Eating Disorders : the Journal of Treatment & Prevention AU - Freudenberg, Cara AU - Jones, Rebecca A AU - Livingston, Genvieve AU - Goetsch, Virginia AU - Schaffner, Angela AU - Buchanan, Linda AD - U.S. Department of Veterans Affairs, Tennessee Valley Healthcare System, Murfreesboro, Tennessee, USA ; Georgia School of Professional Psychology, Argosy University, Atlanta, Georgia, USA ; Atlanta Center for Eating Disorders and School of Counseling, Richmont Graduate University, Atlanta, Georgia, USA ; Atlanta Center for Eating Disorders, Atlanta, Georgia, USA Y1 - 2016///May/Jun PY - 2016 DA - May/Jun 2016 SP - 240 EP - 254 CY - New York PB - Taylor & Francis Ltd. VL - 24 IS - 3 SN - 1064-0266 KW - Psychology KW - Anorexia nervosa KW - Binge eating KW - Body weight KW - Bulimia nervosa KW - Eating disorders KW - Efficacy KW - Hospitalization KW - Individualized KW - Outpatient treatment KW - Purging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1786270411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eating+Disorders+%3A+the+Journal+of+Treatment+%26+Prevention&rft.atitle=Effectiveness+of+individualized%2C+integrative+outpatient+treatment+for+females+with+anorexia+nervosa+and+bulimia+nervosa&rft.au=Freudenberg%2C+Cara%3BJones%2C+Rebecca+A%3BLivingston%2C+Genvieve%3BGoetsch%2C+Virginia%3BSchaffner%2C+Angela%3BBuchanan%2C+Linda&rft.aulast=Freudenberg&rft.aufirst=Cara&rft.date=2016-05-01&rft.volume=24&rft.issue=3&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Eating+Disorders+%3A+the+Journal+of+Treatment+%26+Prevention&rft.issn=10640266&rft_id=info:doi/10.1080%2F10640266.2015.1090868 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © 2016 Taylor & Francis N1 - Last updated - 2016-08-17 DO - http://dx.doi.org/10.1080/10640266.2015.1090868 ER - TY - JOUR T1 - Identifying gaps for research prioritisation: Global burden of external causes of injury as reflected in the Cochrane Database of Systematic Reviews. AN - 1785748312; 26804937 AB - IMPORTANCE Burden of disease should impact research prioritisation. OBJECTIVE To analyse the Cochrane Database of Systematic Reviews (CDSR) and determine whether systematic reviews and protocols accurately represent disease burden, as measured by disability-adjusted life years (DALYs) from the Global Burden of Disease (GBD) 2010 Study. METHODS Two investigators collected GBD disability metrics for 12 external causes of injury in the GBD 2010 Study. These external causes were then assessed for systematic review and protocol representation in CDSR. Data was collected during the month of April 2015. There were no study participants aside from the researchers. Percentage of total 2010 DALYs, 2010 DALY rank, and median DALY percent change from 1990 to 2010 of the 12 external causes of injury were compared with CDSR representation of systematic reviews and protocols. Data were analysed for correlation using Spearman rank correlation. RESULTS Eleven of the 12 causes were represented by at least one systematic review or protocol in CDSR; the category collective violence and legal intervention had no representation in CDSR. Correlation testing revealed a strong positive correlation that was statistically significant. Representation of road injury; interpersonal violence; fire, heat, and hot substances; mechanical forces; poisonings, adverse effect of medical treatment, and animal contact was well aligned with respect to DALY. Representation of falls was greater compared to DALY, while self-harm, exposure to forces of nature, and other transport injury representation was lower compared to DALY. CONCLUSIONS AND RELEVANCE CDSR representation of external causes of injury strongly correlates with disease burden. The number of systematic reviews and protocols was well aligned for seven out of 12 causes of injury. These results provide high-quality and transparent data that may guide future prioritisation decisions. JF - Injury AU - Karimkhani, Chante AU - Trikha, Ritika AU - Aksut, Baran AU - Jones, Trevor AU - Boyers, Lindsay N AU - Schlichte, Megan AU - Pederson, Hannah AU - Okland, Tyler AU - DiGuiseppi, Carolyn AU - Nasser, Mona AU - Naghavi, Mohsen AU - Vos, Theo AU - Yoong, Sze Lin AU - Wolfenden, Luke AU - Murray, Christopher J L AU - Dellavalle, Robert P AD - Columbia University College of Physicians and Surgeons, New York, NY, USA. ; Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. ; Columbia University Medical Center, New York, NY, USA. ; University of Arizona College of Medicine, Tucson, AZ, USA. ; Georgetown University School of Medicine, Washington DC, USA. ; Baylor College of Medicine, Houston, TX, USA. ; University of Colorado School of Medicine, Aurora, CO, USA. ; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, CO, USA. ; Peninsula Dental School, Plymouth University, Plymouth, UK. ; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA. ; Hunter New England Population Health, NSW, Australia; The University of Newcastle, NSW, Australia. ; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, CO, USA; Department of Dermatology, University of Colorado Anschutz Medical Campus, CO, USA; Department of Dermatology, Denver Veterans Administration Hospital, CO, USA. Electronic address: robert.dellavalle@ucdenver.edu. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 1151 EP - 1157 VL - 47 IS - 5 KW - Index Medicus KW - Injury KW - Epidemiology KW - DALY KW - Burden of disease KW - Disability KW - Systematic review KW - Cochrane KW - Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785748312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury&rft.atitle=Identifying+gaps+for+research+prioritisation%3A+Global+burden+of+external+causes+of+injury+as+reflected+in+the+Cochrane+Database+of+Systematic+Reviews.&rft.au=Karimkhani%2C+Chante%3BTrikha%2C+Ritika%3BAksut%2C+Baran%3BJones%2C+Trevor%3BBoyers%2C+Lindsay+N%3BSchlichte%2C+Megan%3BPederson%2C+Hannah%3BOkland%2C+Tyler%3BDiGuiseppi%2C+Carolyn%3BNasser%2C+Mona%3BNaghavi%2C+Mohsen%3BVos%2C+Theo%3BYoong%2C+Sze+Lin%3BWolfenden%2C+Luke%3BMurray%2C+Christopher+J+L%3BDellavalle%2C+Robert+P&rft.aulast=Karimkhani&rft.aufirst=Chante&rft.date=2016-05-01&rft.volume=47&rft.issue=5&rft.spage=1151&rft.isbn=&rft.btitle=&rft.title=Injury&rft.issn=1879-0267&rft_id=info:doi/10.1016%2Fj.injury.2015.12.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-04-29 N1 - Date revised - 2017-02-09 N1 - SuppNotes - Cited By: Acad Emerg Med. 2003 Mar;10(3):251-60 [12615591] Health Policy Plan. 2003 Dec;18(4):351-6 [14654511] Am J Public Health. 2005 Jan;95(1):13-7 [15623852] PLoS One. 2011;6(2):e16837 [21383981] Implement Sci. 2012;7:50 [22651257] Lancet. 2012 Dec 15;380(9859):2163-96 [23245607] BMC Health Serv Res. 2012;12:454 [23234463] N Engl J Med. 2013 Aug 1;369(5):448-57 [23902484] JAMA Dermatol. 2014 Sep;150(9):945-51 [24807687] JAMA Ophthalmol. 2015 Jan;133(1):25-31 [25232930] JAMA Otolaryngol Head Neck Surg. 2015 Jan;141(1):67-72 [25356671] BMJ. 2015;350:h117 [25630558] J Epidemiol Community Health. 2015 Jul;69(7):708-14 [25888595] N1 - Last updated - 2017-02-09 DO - http://dx.doi.org/10.1016/j.injury.2015.12.019 ER - TY - JOUR T1 - Perceptions of Duchenne and non-Duchenne smiles: A meta-analysis AN - 1784151440 AB - A meta-analysis was conducted to compare perceptions of Duchenne smiles, smiles that include activation of the cheek raiser muscle that creates crow's feet around the eyes, with perceptions of non-Duchenne smiles, smiles without cheek raiser activation. In addition to testing the overall effect, moderator analyses were conducted to test how methodological, stimulus-specific and perceiver-specific differences between studies predicted the overall effect size. The meta-analysis found that, overall, Duchenne smiles and people producing Duchenne smiles are rated more positively (i.e., authentic, genuine, real, attractive, trustworthy) than non-Duchenne smiles and people producing non-Duchenne smiles. The difference between Duchenne and non-Duchenne smiles was greater when the stimuli were videos rather than photographs, when smiles were elicited naturally rather than through posing paradigms and when Duchenne and non-Duchenne smiles were not matched for intensity of the lip corner puller in addition to other perceiver and methodological moderators. JF - Cognition & Emotion AU - Gunnery, Sarah D AU - Ruben, Mollie A AD - Department of Occupational Therapy, Tufts University, Medford, MA, USA ; Center for Healthcare Organization and Implementation Research, United States Department of Veterans Affairs, Boston, MA, USA Y1 - 2016/04// PY - 2016 DA - Apr 2016 SP - 501 EP - 515 CY - Hove PB - Taylor & Francis Ltd. VL - 30 IS - 3 SN - 0269-9931 KW - Psychology KW - Duchenne smile KW - Non-Duchenne smile KW - Smile perceptions KW - Analysis KW - Feet KW - Models KW - Moderators KW - Perceptions KW - Photographs KW - Smiles KW - Stimulus KW - Videotapes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1784151440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cognition+%26+Emotion&rft.atitle=Perceptions+of+Duchenne+and+non-Duchenne+smiles%3A+A+meta-analysis&rft.au=Gunnery%2C+Sarah+D%3BRuben%2C+Mollie+A&rft.aulast=Gunnery&rft.aufirst=Sarah&rft.date=2016-04-01&rft.volume=30&rft.issue=3&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Cognition+%26+Emotion&rft.issn=02699931&rft_id=info:doi/10.1080%2F02699931.2015.1018817 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © 2015 Taylor & Francis N1 - Last updated - 2016-09-07 DO - http://dx.doi.org/10.1080/02699931.2015.1018817 ER - TY - JOUR T1 - Molecular testing to optimize therapeutic decision making in advanced colorectal cancer. AN - 1777982542; 27034809 AB - Colorectal cancer (CRC) is a leading cause of cancer death in the United States. In recent years, therapeutic advances have prolonged the survival of patients with advanced disease. Along with the addition of new treatments, an increasing body of literature explores the potential benefit of using molecular testing to define tumor, circulating, or host biomarkers of benefit to specific treatment strategies. At present, testing for specific mutations in exons 2, 3, and 4 of KRAS and NRAS has become accepted practice to select patients for treatment with epidermal growth factor receptor (EGFR)-targeted agents. Additionally, testing for the BRAF V600E mutation is used to refine decisions based on patient prognosis. The presence of the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) *28 polymorphism is associated with toxicity from irinotecan, although it has not been universally applied. Nonetheless, molecular markers to predict response and toxicity of cytotoxic therapy are evolving. While the development of selection biomarkers for anti-angiogenic treatments has not proved fruitful to date, improved development strategies and novel targeted agents are anticipated to revolutionize the approach to treatment of advanced CRC in the near future. This review summarizes currently available data to select treatment strategies in patients with advanced CRC. JF - Journal of gastrointestinal oncology AU - Semrad, Thomas J AU - Kim, Edward J AD - 1 Division of Hematology/Oncology, Department of Internal Medicine, University of California Davis Comprehensive Cancer Center, Sacramento, California, USA ; 2 Veterans Administration Northern California Healthcare System, Mather, California, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - S11 EP - S20 VL - 7 SN - 2078-6891, 2078-6891 KW - biomarker KW - Colorectal cancer (CRC) KW - BRAF KW - RAS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777982542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gastrointestinal+oncology&rft.atitle=Molecular+testing+to+optimize+therapeutic+decision+making+in+advanced+colorectal+cancer.&rft.au=Semrad%2C+Thomas+J%3BKim%2C+Edward+J&rft.aulast=Semrad&rft.aufirst=Thomas&rft.date=2016-04-01&rft.volume=7&rft.issue=&rft.spage=S11&rft.isbn=&rft.btitle=&rft.title=Journal+of+gastrointestinal+oncology&rft.issn=20786891&rft_id=info:doi/10.3978%2Fj.issn.2078-6891.2015.094 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-01 N1 - Date created - 2016-04-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3978/j.issn.2078-6891.2015.094 ER - TY - JOUR T1 - Epoxyeicosatrienoic acid analogue mitigates kidney injury in a rat model of radiation nephropathy. AN - 1772143764; 26772189 AB - Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by CYP epoxygenases, and EETs are kidney protective in multiple pathologies. We determined the ability of an EET analogue, EET-A, to mitigate experimental radiation nephropathy. The kidney expression of the EET producing enzyme CYP2C11 was lower in rats that received total body irradiation (TBI rat) compared with non-irradiated control. At 12 weeks after TBI, the rats had higher systolic blood pressure and impaired renal afferent arteriolar function compared with control, and EET-A or captopril mitigated these abnormalities. The TBI rats had 3-fold higher blood urea nitrogen (BUN) compared with control, and EET-A or captopril decreased BUN by 40-60%. The urine albumin/creatinine ratio was increased 94-fold in TBI rats, and EET-A or captopril attenuated that increase by 60-90%. In TBI rats, nephrinuria was elevated 30-fold and EET-A or captopril decreased it by 50-90%. Renal interstitial fibrosis, tubular and glomerular injury were present in the TBI rats, and each was decreased by EET-A or captopril. We further demonstrated elevated renal parenchymal apoptosis in TBI rats, which was mitigated by EET-A or captopril. Additional studies revealed that captopril or EET-A mitigated renal apoptosis by acting on the p53/Fas/FasL (Fas ligand) apoptotic pathway. The present study demonstrates a novel EET analogue-based strategy for mitigation of experimental radiation nephropathy by improving renal afferent arteriolar function and by decreasing renal apoptosis. © 2016 Authors; published by Portland Press Limited. JF - Clinical science (London, England : 1979) AU - Hye Khan, Md Abdul AU - Fish, Brian AU - Wahl, Geneva AU - Sharma, Amit AU - Falck, John R AU - Paudyal, Mahesh P AU - Moulder, John E AU - Imig, John D AU - Cohen, Eric P AD - Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A. ; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A. ; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, U.S.A. ; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A. Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, U.S.A. Eric.Cohen@va.gov. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 587 EP - 599 VL - 130 IS - 8 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Antigens, CD95 KW - Eicosanoids KW - Fas Ligand Protein KW - Radiation-Protective Agents KW - Tnfrsf6 protein, rat KW - Tnfsf6 protein, rat KW - Captopril KW - 9G64RSX1XD KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP2C11 protein, rat KW - Cytochrome P450 Family 2 KW - Steroid 16-alpha-Hydroxylase KW - Index Medicus KW - afferent arteriole KW - Fas KW - apoptosis KW - novel small lipid molecule KW - radiotherapy KW - Animals KW - Renal Circulation -- drug effects KW - Hypertension -- physiopathology KW - Steroid 16-alpha-Hydroxylase -- metabolism KW - Fibrosis KW - Cytoprotection KW - Albuminuria -- prevention & control KW - Blood Urea Nitrogen KW - Angiotensin-Converting Enzyme Inhibitors -- pharmacology KW - Captopril -- pharmacology KW - Rats KW - Antigens, CD95 -- metabolism KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Albuminuria -- metabolism KW - Hypertension -- prevention & control KW - Signal Transduction -- drug effects KW - Apoptosis -- drug effects KW - Blood Pressure -- drug effects KW - Male KW - Hypertension -- metabolism KW - Fas Ligand Protein -- metabolism KW - Kidney -- radiation effects KW - Radiation Injuries, Experimental -- pathology KW - Kidney -- metabolism KW - Radiation Injuries, Experimental -- metabolism KW - Kidney -- pathology KW - Kidney -- drug effects KW - Acute Kidney Injury -- prevention & control KW - Radiation-Protective Agents -- pharmacology KW - Acute Kidney Injury -- metabolism KW - Acute Kidney Injury -- pathology KW - Eicosanoids -- pharmacology KW - Acute Kidney Injury -- physiopathology KW - Kidney -- blood supply KW - Radiation Injuries, Experimental -- physiopathology KW - Radiation Injuries, Experimental -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1772143764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+science+%28London%2C+England+%3A+1979%29&rft.atitle=Epoxyeicosatrienoic+acid+analogue+mitigates+kidney+injury+in+a+rat+model+of+radiation+nephropathy.&rft.au=Hye+Khan%2C+Md+Abdul%3BFish%2C+Brian%3BWahl%2C+Geneva%3BSharma%2C+Amit%3BFalck%2C+John+R%3BPaudyal%2C+Mahesh+P%3BMoulder%2C+John+E%3BImig%2C+John+D%3BCohen%2C+Eric+P&rft.aulast=Hye+Khan&rft.aufirst=Md&rft.date=2016-04-01&rft.volume=130&rft.issue=8&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Clinical+science+%28London%2C+England+%3A+1979%29&rft.issn=1470-8736&rft_id=info:doi/10.1042%2FCS20150778 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-18 N1 - Date created - 2016-03-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1042/CS20150778 ER - TY - JOUR T1 - The human colonic thiamine pyrophosphate transporter (hTPPT) is a glycoprotein and N-linked glycosylation is important for its function. AN - 1771452116; 26828122 AB - The recently identified human thiamine pyrophosphate transporter (hTPPT; product of the SLC44A4 gene) is responsible for absorption of the microbiota-generated TPP in the large intestine. The hTPPT is highly expressed in the colon, but not in other regions of the intestinal tract and is localized exclusively at the apical membrane domain of epithelia. The hTPPT protein is predicted to have multiple TM domains with a number of putative N-glycosylation sites, but it is not known if the protein is actually glycosylated, and if so at which site, and their role in the functionality of the transporter. Using several approaches including inhibiting de novo N-glycosylation in human colonic epithelial NCM460 cells with tunicamycin as well as enzymatic de-glycosylation, we show that the hTPPT protein is, indeed, a glycoprotein. Glycosylation of hTPPT was shown, by mean of site-directed mutagenesis, to occur at Asn(69), Asn(155), Asn(197), Asn(393), and Asn(416). However, only N-glycosylation at Asn(69), Asn(155), and Asn(393) appeared to be important for transporter functionality possibly through an effect on protein conformation and/or interaction with its ligand (but not through changes in expression at the cell membrane as determined by live cell confocal imaging). Results of this study showed, for the first time, that the hTPPT is glycosylated and that N-linked glycosylation occurs at multiple sites with some of them being important for function. The results also provide an indirect support for a membrane topology for hTPPT with 10 transmembrane domains as predicted by the TMHMM transmembrane helixes prediction program. Published by Elsevier B.V. JF - Biochimica et biophysica acta AU - Nabokina, Svetlana M AU - Subramanian, Veedamali S AU - Said, Hamid M AD - Department of Medicine, University of California, Irvine, CA 92697, United States; Department of Physiology/Biophysics, University of California, Irvine, CA 92697, United States; Department of Veterans Affairs Medical Center, Long Beach, CA 90822, United States. ; Department of Medicine, University of California, Irvine, CA 92697, United States; Department of Physiology/Biophysics, University of California, Irvine, CA 92697, United States; Department of Veterans Affairs Medical Center, Long Beach, CA 90822, United States. Electronic address: hmsaid@uci.edu. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 866 EP - 871 VL - 1858 IS - 4 SN - 0006-3002, 0006-3002 KW - Glycoproteins KW - 0 KW - Membrane Transport Proteins KW - choline transporter-like protein 4, human KW - Index Medicus KW - Transport KW - Thiamine pyrophosphate KW - Uptake KW - Glycosylation KW - Mutation KW - Mutagenesis, Site-Directed KW - Epithelial Cells -- metabolism KW - Glycoproteins -- metabolism KW - Glycoproteins -- chemistry KW - Humans KW - Protein Structure, Secondary KW - Colon -- metabolism KW - Membrane Transport Proteins -- chemistry KW - Colon -- chemistry KW - Cell Membrane -- chemistry KW - Cell Membrane -- metabolism KW - Membrane Transport Proteins -- metabolism KW - Membrane Transport Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1771452116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=The+human+colonic+thiamine+pyrophosphate+transporter+%28hTPPT%29+is+a+glycoprotein+and+N-linked+glycosylation+is+important+for+its+function.&rft.au=Nabokina%2C+Svetlana+M%3BSubramanian%2C+Veedamali+S%3BSaid%2C+Hamid+M&rft.aulast=Nabokina&rft.aufirst=Svetlana&rft.date=2016-04-01&rft.volume=1858&rft.issue=4&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbamem.2016.01.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-17 N1 - Date created - 2016-03-07 N1 - Date revised - 2017-02-03 N1 - SuppNotes - Cited By: Gastroenterology. 2010 May;138(5):1802-9 [19879271] PLoS One. 2010;5(10):e13616 [21049048] Nature. 2011 May 12;473(7346):174-80 [21508958] Biochim Biophys Acta. 2011 Aug;1808(8):2073-80 [21570947] Biochem J. 2011 Aug 1;437(3):357-72 [21749321] Cent Nerv Syst Agents Med Chem. 2012 Jun;12(2):70-81 [22483272] Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G389-95 [22628036] Mol Aspects Med. 2013 Apr-Jun;34(2-3):646-54 [23506897] Am J Physiol Gastrointest Liver Physiol. 2013 Nov;305(9):G601-10 [23989008] J Biol Chem. 2014 Feb 14;289(7):4405-16 [24379411] Metab Brain Dis. 2014 Dec;29(4):1069-82 [24590690] World Rev Nutr Diet. 2015;111:30-7 [25418386] Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1835-40 [10677542] Proc Soc Exp Biol Med. 2000 Sep;224(4):246-55 [10964259] J Biol Chem. 2001 Jan 19;276(3):2168-73 [11036075] Am J Physiol Cell Physiol. 2001 Sep;281(3):C786-92 [11502555] Curr Mol Med. 2001 May;1(2):197-207 [11899071] J Biol Chem. 2003 Feb 7;278(6):3976-84 [12454006] Nat Med. 2003 Mar;9(3):294-9 [12592403] Diabetes. 2003 Aug;52(8):2110-20 [12882930] Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G491-8 [14615284] Anal Biochem. 1989 Aug 1;180(2):195-204 [2510544] J Neurochem. 1995 May;64(5):2013-21 [7722487] J Neuropathol Exp Neurol. 1999 Sep;58(9):946-58 [10499437] Am J Physiol. 1999 Oct;277(4 Pt 1):C645-51 [10516094] Mol Pharmacol. 2005 Mar;67(3):868-76 [15576633] Am J Physiol Cell Physiol. 2006 Jan;290(1):C1-C10 [16338974] Biochim Biophys Acta. 2008 Jun;1778(6):1407-14 [18405659] Biochem Biophys Res Commun. 2008 Sep 12;374(1):123-7 [18619416] Basic Clin Pharmacol Toxicol. 2008 Nov;103(5):482-6 [18715237] Am J Physiol Renal Physiol. 2009 Mar;296(3):F459-69 [18971212] Alcohol Alcohol. 2009 Mar-Apr;44(2):141-7 [19151161] FEBS J. 2009 Jun;276(11):2917-25 [19490098] N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1016/j.bbamem.2016.01.028 ER - TY - JOUR T1 - Important Complexities of the Antivirulence Target Paradigm: A Novel Ostensibly Resistance-Avoiding Approach for Treating Infections AN - 1785227593; PQ0002903385 AB - Use of antivirulence therapy has assumed that inhibition of bacterial fitness at the site of infection without directly affecting viability will minimize the development of resistance. However, selection for resistant strains is much more likely to occur at sites of colonization or in the environment following excretion of the therapeutic agent. Data are needed regarding whether the drug's target promotes fitness among bacteria in (drug-exposed) niches other than sites of infection. Furthermore, in vivo studies of resistance selection should assess off-target selection for resistance (eg, within the microbiome). Only when such data are available can the risk for development of resistance be gauged appropriately. JF - Journal of Infectious Diseases AU - Russo, Thomas A AU - Spellberg, Brad AU - Johnson, James R AD - Veterans Administration Western New York Healthcare System, trusso@buffalo.edu Y1 - 2016/03/15/ PY - 2016 DA - 2016 Mar 15 SP - 901 EP - 903 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 213 IS - 6 SN - 0022-1899, 0022-1899 KW - Health & Safety Science Abstracts KW - antivirulence therapy KW - antimicrobial resistance KW - antimicrobial targets KW - virulence factors KW - microbiome KW - resistance selection KW - Risk assessment KW - Colonization KW - Infectious diseases KW - Niches KW - Excretion KW - Infection KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785227593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Important+Complexities+of+the+Antivirulence+Target+Paradigm%3A+A+Novel+Ostensibly+Resistance-Avoiding+Approach+for+Treating+Infections&rft.au=Russo%2C+Thomas+A%3BSpellberg%2C+Brad%3BJohnson%2C+James+R&rft.aulast=Russo&rft.aufirst=Thomas&rft.date=2016-03-15&rft.volume=213&rft.issue=6&rft.spage=901&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv533 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Risk assessment; Colonization; Infectious diseases; Niches; Excretion; Infection DO - http://dx.doi.org/10.1093/infdis/jiv533 ER - TY - JOUR T1 - Successful Treatment of Multi-Drug Resistant Pseudomonas aeruginosa Bacteremia with the Recommended Renally Adjusted Ceftolozane/Tazobactam Regimen AN - 1785248255; PQ0002867820 AB - Ceftolozane/tazobactam (C/T) is a novel antibiotic approved for complicated intra-abdominal and urinary tract infections caused by Gram-positive and Gram-negative organisms, including some MDR strains. Little is known about the use of this agent for treatment of bacteremia and even less so about the appropriateness of the renally defined regimens. We describe a case of a 66-year-old man with a history of chronic kidney disease (baseline Cr = 3-4 mg/dl) and recurrent nephrolithiasis with bilateral stents who had positive concurrent urine and blood cultures for MDR Pseudomonas aeruginosa (PSA), susceptible only to amikacin and colistin. Due to the MDR phenotype and his underlying kidney disease, the 375 mg (250 mg/125 mg) dose of C/T was given as monotherapy every 8 h for his bloodstream infection. Once steady state was anticipated, blood was obtained at the end of infusion (1 h), and at 3, 5 and 8 h for drug concentration determination using a validated high-performance liquid chromatography method at the Center for Anti-Infective Research and Development, Hartford Hospital, Hartford. The minimum inhibitory concentration (MIC) for the PSA was 2/4 for C/T, indicating susceptibility. Concentration of ceftolozane of 21.87 mu g/ml at 8 h indicated that serum concentrations were maintained above the MIC throughout the dosing interval. The patient was given 25 days of C/T and experienced a successful clinical outcome. Blood cultures obtained at 1 and 3 weeks after completion of treatment remained sterile. No adverse events were attributed to C/T. In this patient, the renally adjusted dose of C/T was safe and provided sufficiently high drug concentrations that exceeded the MIC of the infecting organism over the course of therapy. More data are required to determine the clinical utility of C/T in the setting of MDR PSA bacteremia. JF - Infectious Diseases and Therapy AU - Patel, Ursula C AU - Nicolau, David P AU - Sabzwari, Rabeeya K AD - Department of Pharmacy, Edward Hines, Jr. VA Medical Center, Hines, IL, 60141, USA, ursula.patel@va.gov Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 73 EP - 79 PB - Springer Science & Business Media, Cheshire VL - 5 IS - 1 SN - 2193-8229, 2193-8229 KW - Microbiology Abstracts B: Bacteriology KW - Blood culture KW - High-performance liquid chromatography KW - Data processing KW - Amikacin KW - Kidney diseases KW - Bacteremia KW - Tazobactam KW - Antibiotics KW - Drug development KW - Urinary tract KW - Minimum inhibitory concentration KW - Colistin KW - Urine KW - Implants KW - Multidrug resistance KW - Pseudomonas aeruginosa KW - Nephrolithiasis KW - Drugs KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785248255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infectious+Diseases+and+Therapy&rft.atitle=Successful+Treatment+of+Multi-Drug+Resistant+Pseudomonas+aeruginosa+Bacteremia+with+the+Recommended+Renally+Adjusted+Ceftolozane%2FTazobactam+Regimen&rft.au=Patel%2C+Ursula+C%3BNicolau%2C+David+P%3BSabzwari%2C+Rabeeya+K&rft.aulast=Patel&rft.aufirst=Ursula&rft.date=2016-03-01&rft.volume=5&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Infectious+Diseases+and+Therapy&rft.issn=21938229&rft_id=info:doi/10.1007%2Fs40121-016-0104-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Number of references - 23 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Blood culture; Data processing; Amikacin; Kidney diseases; Bacteremia; Drug development; Antibiotics; Tazobactam; Urinary tract; Minimum inhibitory concentration; Colistin; Urine; Implants; Multidrug resistance; Drugs; Nephrolithiasis; Hospitals; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1007/s40121-016-0104-3 ER - TY - JOUR T1 - Alcohol-Related Diagnoses and All-Cause Hospitalization Among HIV-Infected and Uninfected Patients: A Longitudinal Analysis of United States Veterans from 1997 to 2011 AN - 1776663748; PQ0002815375 AB - Individuals with HIV infection are living substantially longer on antiretroviral therapy, but hospitalization rates continue to be relatively high. We do not know how overall or diagnosis-specific hospitalization rates compare between HIV-infected and uninfected individuals or what conditions may drive hospitalization trends. Hospitalization rates among United States Veterans were calculated and stratified by HIV serostatus and principal diagnosis disease category. Because alcohol-related diagnoses (ARD) appeared to have a disproportional effect, we further stratified our calculations by ARD history. A multivariable Cox proportional hazards model was fitted to assess the relative risk of hospitalization controlling for demographic and other comorbidity variables. From 1997 to 2011, 46,428 HIV-infected and 93,997 uninfected patients were followed for 1,497,536 person-years. Overall hospitalization rates decreased among HIV-infected and uninfected patients. However, cardiovascular and renal insufficiency admissions increased for all groups while gastrointestinal and liver, endocrine, neurologic, and non-AIDS cancer admissions increased among those with an alcohol-related diagnosis. After multivariable adjustment, HIV-infected individuals with an ARD had the highest risk of hospitalization (hazard ratio 3.24, 95 % CI 3.00, 3.49) compared to those free of HIV infection and without an ARD. Still, HIV alone also conferred increased risk (HR 2.08, 95 % CI 2.04, 2.13). While decreasing overall, risk of all-cause hospitalization remains higher among HIV-infected than uninfected individuals and is strongly influenced by the presence of an ARD. JF - AIDS and Behavior AU - Rentsch, Christopher AU - Tate, Janet P AU - Akguen, Kathleen M AU - Crystal, Stephen AU - Wang, Karen H AU - Ryan Greysen, S AU - Wang, Emily A AU - Bryant, Kendall J AU - Fiellin, David A AU - Justice, Amy C AU - Rimland, David AD - Infectious Diseases, Atlanta VA Medical Center, Decatur, GA, USA, christopher.rentsch@va.gov Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 555 EP - 564 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 20 IS - 3 SN - 1090-7165, 1090-7165 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Historical account KW - Acquired immune deficiency syndrome KW - antiretroviral therapy KW - Infection KW - Antiretroviral agents KW - Morbidity KW - Cancer KW - Demography KW - Health risks KW - USA KW - Behavior KW - Human immunodeficiency virus KW - Risk factors KW - Kidney KW - Liver KW - Renal insufficiency KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776663748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Alcohol-Related+Diagnoses+and+All-Cause+Hospitalization+Among+HIV-Infected+and+Uninfected+Patients%3A+A+Longitudinal+Analysis+of+United+States+Veterans+from+1997+to+2011&rft.au=Rentsch%2C+Christopher%3BTate%2C+Janet+P%3BAkguen%2C+Kathleen+M%3BCrystal%2C+Stephen%3BWang%2C+Karen+H%3BRyan+Greysen%2C+S%3BWang%2C+Emily+A%3BBryant%2C+Kendall+J%3BFiellin%2C+David+A%3BJustice%2C+Amy+C%3BRimland%2C+David&rft.aulast=Rentsch&rft.aufirst=Christopher&rft.date=2016-03-01&rft.volume=20&rft.issue=3&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-015-1025-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Number of references - 52 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Risk assessment; Demography; Risk factors; antiretroviral therapy; Liver; Renal insufficiency; Infection; Cancer; Historical account; Acquired immune deficiency syndrome; Antiretroviral agents; Morbidity; Health risks; Behavior; Human immunodeficiency virus; Kidney; USA DO - http://dx.doi.org/10.1007/s10461-015-1025-y ER - TY - RPRT T1 - Ventricular Dysrhythmias from Loperamide Misuse. AN - 1767622595; 26794455 JF - The Journal of emergency medicine AU - Lasoff, Daniel R AU - Schneir, Aaron Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 508 EP - 509 KW - Narcotic Antagonists KW - 0 KW - Loperamide KW - 6X9OC3H4II KW - Cimetidine KW - 80061L1WGD KW - Index Medicus KW - Young Adult KW - Tachycardia, Ventricular -- chemically induced KW - Heart Conduction System -- drug effects KW - Humans KW - Cimetidine -- administration & dosage KW - Male KW - Narcotic Antagonists -- poisoning KW - Arrhythmias, Cardiac -- chemically induced KW - Loperamide -- poisoning KW - Substance-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1767622595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Journal+of+emergency+medicine&rft.atitle=Ventricular+Dysrhythmias+from+Loperamide+Misuse.&rft.au=Lasoff%2C+Daniel+R%3BSchneir%2C+Aaron&rft.aulast=Lasoff&rft.aufirst=Daniel&rft.date=2016-03-01&rft.volume=50&rft.issue=3&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+emergency+medicine&rft.issn=07364679&rft_id=info:doi/10.1016%2Fj.jemermed.2015.11.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-16 N1 - Date created - 2016-02-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jemermed.2015.11.017 ER - TY - JOUR T1 - Image Guided Hypofractionated Postprostatectomy Intensity Modulated Radiation Therapy for Prostate Cancer. AN - 1765109212; 26867889 AB - Hypofractionated radiation therapy (RT) has promising long-term biochemical relapse-free survival (bRFS) with comparable toxicity for definitive treatment of prostate cancer. However, data reporting outcomes after adjuvant and salvage postprostatectomy hypofractionated RT are sparse. Therefore, we report the toxicity and clinical outcomes after postprostatectomy hypofractionated RT. From a prospectively maintained database, men receiving image guided hypofractionated intensity modulated RT (HIMRT) with 2.5-Gy fractions constituted our study population. Androgen deprivation therapy was used at the discretion of the radiation oncologist. Acute toxicities were graded according to the Common Terminology Criteria for Adverse Events version 4.0. Late toxicities were scored using the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer scale. Biochemical recurrence was defined as an increase of 0.1 in prostate-specific antigen (PSA) from posttreatment nadir or an increase in PSA despite treatment. The Kaplan-Meier method was used for the time-to-event outcomes. Between April 2008 and April 2012, 56 men received postoperative HIMRT. The median follow-up time was 48 months (range, 21-67 months). Thirty percent had pre-RT PSA <0.1; the median pre-RT detectable PSA was 0.32 ng/mL. The median RT dose was 65 Gy (range, 57.5-65 Gy). Ten patients received neoadjuvant and concurrent hormone therapy. Posttreatment acute urinary toxicity was limited. There was no acute grade 3 toxicity. Late genitourinary (GU) toxicity of any grade was noted in 52% of patients, 40% of whom had pre-RT urinary incontinence. The 4-year actuarial rate of late grade 3 GU toxicity (exclusively gross hematuria) was 28% (95% confidence interval [CI], 16%-41%). Most grade 3 GU toxicity resolved; only 7% had persistent grade ≥3 toxicity at the last follow-up visit. Fourteen patients experienced biochemical recurrence at a median of 20 months after radiation. The 4-year bPFS rate was 75% (95% CI, 63%-87%). The biochemical control in this series appears promising, although relatively short follow-up may lead to overestimation. Late grade 3 GU toxicity was higher than anticipated with hypofractionated radiation of 65 Gy to the prostate bed, although most resolved. Copyright © 2016 Elsevier Inc. All rights reserved. JF - International journal of radiation oncology, biology, physics AU - Lewis, Stephen L AU - Patel, Pretesh AU - Song, Haijun AU - Freedland, Stephen J AU - Bynum, Sigrun AU - Oh, Daniel AU - Palta, Manisha AU - Yoo, David AU - Oleson, James AU - Salama, Joseph K AD - Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina. ; Surgery Section, Durham Veterans Administration, and Division of Urology, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California. ; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina. Electronic address: joseph.salama@duke.edu. Y1 - 2016/03/01/ PY - 2016 DA - 2016 Mar 01 SP - 605 EP - 611 VL - 94 IS - 3 KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Index Medicus KW - Prostatectomy KW - Postoperative Care KW - Humans KW - Prostate-Specific Antigen -- blood KW - Adult KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Time Factors KW - Male KW - Radiotherapy, Image-Guided -- methods KW - Radiotherapy, Intensity-Modulated -- methods KW - Radiotherapy, Image-Guided -- adverse effects KW - Prostatic Neoplasms -- surgery KW - Prostatic Neoplasms -- blood KW - Dose Hypofractionation KW - Radiotherapy, Intensity-Modulated -- adverse effects KW - Prostatic Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765109212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Image+Guided+Hypofractionated+Postprostatectomy+Intensity+Modulated+Radiation+Therapy+for+Prostate+Cancer.&rft.au=Lewis%2C+Stephen+L%3BPatel%2C+Pretesh%3BSong%2C+Haijun%3BFreedland%2C+Stephen+J%3BBynum%2C+Sigrun%3BOh%2C+Daniel%3BPalta%2C+Manisha%3BYoo%2C+David%3BOleson%2C+James%3BSalama%2C+Joseph+K&rft.aulast=Lewis&rft.aufirst=Stephen&rft.date=2016-03-01&rft.volume=94&rft.issue=3&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=1879-355X&rft_id=info:doi/10.1016%2Fj.ijrobp.2015.11.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-16 N1 - Date created - 2016-02-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment In: Int J Radiat Oncol Biol Phys. 2016 Mar 15;94(4):860-1 [26972661] Int J Radiat Oncol Biol Phys. 2016 Mar 15;94(4):859-60 [26972660] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ijrobp.2015.11.025 ER - TY - JOUR T1 - Analysis of the Structure and Function of FOX-4 Cephamycinase AN - 1768588190; PQ0002688441 AB - Class C beta -lactamases poorly hydrolyze cephamycins (e.g., cefoxitin, cefotetan, and moxalactam). In the past 2 decades, a new family of plasmid-based AmpC beta -lactamases conferring resistance to cefoxitin, the FOX family, has grown to include nine unique members descended from the Aeromonas caviae chromosomal AmpC. To understand the basis for the unique cephamycinase activity in the FOX family, we determined the first X-ray crystal structures of FOX-4, apo enzyme and the acyl-enzyme with its namesake compound, cefoxitin, using the Y150F deacylation-deficient variant. Notably, recombinant expression of N-terminally tagged FOX-4 also yielded an inactive adenylylated enzyme form not previously observed in beta -lactamases. The posttranslational modification (PTM), which occurs on the active site Ser64, would not seem to provide a selective advantage, yet might present an opportunity for the design of novel antibacterial drugs. Substantial ligand-induced changes in the enzyme are seen in the acyl-enzyme complex, particularly the R2 loop and helix H10 (P289 to N297), with movement of F293 by 10.3 Aa. Taken together, this study provides the first picture of this highly proficient class C cephamycinase, uncovers a novel PTM, and suggests a possible cephamycin resistance mechanism involving repositioning of the substrate due to the presence of S153P, N289P, and N346I substitutions in the ligand binding pocket. JF - Antimicrobial Agents & Chemotherapy AU - Lefurgy, S T AU - Malashkevich, V N AU - Aguilan, J T AU - Nieves, E AU - Mundorff, E C AU - Biju, B AU - Noel, M A AU - Toro, R AU - Baiwir, D AU - Papp-Wallace, K M AD - << + $0, robert.bonomo@va.gov. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 717 EP - 728 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 60 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Moxalactam KW - beta -Lactamase KW - New families KW - Enzymes KW - Drug development KW - Cefotetan KW - Aeromonas caviae KW - Cephamycins KW - Structure-function relationships KW - Ionizing radiation KW - Crystal structure KW - Cefoxitin KW - Drugs KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768588190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Analysis+of+the+Structure+and+Function+of+FOX-4+Cephamycinase&rft.au=Lefurgy%2C+S+T%3BMalashkevich%2C+V+N%3BAguilan%2C+J+T%3BNieves%2C+E%3BMundorff%2C+E+C%3BBiju%2C+B%3BNoel%2C+M+A%3BToro%2C+R%3BBaiwir%2C+D%3BPapp-Wallace%2C+K+M&rft.aulast=Lefurgy&rft.aufirst=S&rft.date=2016-02-01&rft.volume=60&rft.issue=2&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01887-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 41 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Moxalactam; Cephamycins; beta -Lactamase; New families; Structure-function relationships; Ionizing radiation; Crystal structure; Enzymes; Drug development; Drugs; Cefoxitin; Cefotetan; Aeromonas caviae DO - http://dx.doi.org/10.1128/AAC.01887-15 ER - TY - JOUR T1 - Biomechanical effects of anterior capsular plication and rotator interval closure in simulated anterior shoulder instability AN - 1768577507; PQ0002649475 AB - Purpose: The purpose of this study was to determine the effect of a stepwise arthroscopic anterior plication and arthroscopic-equivalent rotator interval (RI) closure on glenohumeral range of motion, kinematics, and translation in the setting of anterior instability. Methods: Six cadaveric shoulders were stretched to 10 % beyond maximum external rotation (ER) to create an anterior shoulder instability model. Range of motion, kinematics, and glenohumeral translations were recorded for the following conditions: (1) intact, (2) stretched, (3) after anterior capsular plication, and (4) after RI closure. Results: The total range of motion after capsular stretching increased significantly in the 60 degree abduction position (p = 0.037). Average ER and total rotation were significantly decreased from the intact and stretched conditions by both repair conditions at 60 degree and 0 degree of glenohumeral abduction (p < 0.05), with no significant difference between plication and additional RI closure. At 0 degree abduction and 0 degree ER, glenohumeral translation decreased significantly from the stretched condition after RI closure with 10 and 15 N anterior and 10 N posterior loads (p < 0.05). At 30 degree ER, translation after RI closure was significantly less than both the intact and stretched conditions with 10 N anterior loads (p = 0.009; p = 0.004). These changes in translational stability were not seen with plication alone. Conclusions: Anterior capsular plication reduced glenohumeral range of motion back to the intact state, and often tighter. RI closure did not contribute significantly to the reduction in the range of motion, but had implications regarding glenohumeral translation. Caution should be taken when performing anterior plication and combined repairs to avoid overtightening. Intraoperative translations could be useful when debating RI closure in patients with unidirectional anterior glenohumeral instability. JF - Knee Surgery, Sports Traumatology, Arthroscopy AU - Sodl, Jeffrey F AU - McGarry, Michelle H AU - Campbell, Sean T AU - Tibone, James E AU - Lee, Thay Q AD - Orthopaedic Biomechanics Laboratory, VA Long Beach Healthcare System (09/151), 5901 East 7th. Street, Long Beach, CA, 90822, USA, tqlee@va.gov Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 365 EP - 373 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 24 IS - 2 SN - 0942-2056, 0942-2056 KW - Physical Education Index KW - Kinematics KW - Flexibility KW - Surgery KW - Shoulders KW - Work load KW - Sports KW - Stability KW - Biomechanics KW - Stretching KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768577507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.atitle=Biomechanical+effects+of+anterior+capsular+plication+and+rotator+interval+closure+in+simulated+anterior+shoulder+instability&rft.au=Sodl%2C+Jeffrey+F%3BMcGarry%2C+Michelle+H%3BCampbell%2C+Sean+T%3BTibone%2C+James+E%3BLee%2C+Thay+Q&rft.aulast=Sodl&rft.aufirst=Jeffrey&rft.date=2016-02-01&rft.volume=24&rft.issue=2&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.issn=09422056&rft_id=info:doi/10.1007%2Fs00167-014-2878-8 LA - English DB - Physical Education Index N1 - Date revised - 2016-02-01 N1 - Number of references - 39 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Kinematics; Surgery; Flexibility; Work load; Shoulders; Stability; Sports; Biomechanics; Stretching DO - http://dx.doi.org/10.1007/s00167-014-2878-8 ER - TY - JOUR T1 - The biomechanical effect of shoulder remplissage combined with Bankart repair for the treatment of engaging Hill-Sachs lesions AN - 1768577497; PQ0002649479 AB - Purpose: The purpose of this study was to determine the biomechanical effects of the remplissage repair combined with Bankart repair for engaging Hill-Sachs lesions on range of motion (ROM), translation, and glenohumeral kinematics. Methods: Six cadaveric shoulders were tested using a custom shoulder testing system. ROM, kinematics, and anterior-posterior (AP) and superior-inferior glenohumeral translations were quantified at 0 degree and 60 degree glenohumeral abduction. Six conditions were tested: intact, Bankart lesion, Bankart with 40 % Hill-Sachs lesion, Bankart repair, Bankart repair with remplissage, and remplissage repair alone. Results: Humeral external rotation (ER) and total range of motion increased significantly after the creation of the Bankart lesion at both 0 degree and 60 degree abduction. The Bankart repair restored ER to intact values at 0 degree and 60 degree abduction, and the addition of the remplissage repair did not significantly alter range of motion from the Bankart repair alone. AP translation increased following the creation of the Bankart and Hill-Sachs lesions and was restored with the Bankart repair; the remplissage did not alter translation from the Bankart repair alone. At maximum ER at 60 degree abduction, the apex of the humeral head shifted posteriorly and inferiorly with remplissage repair. Conclusions: The addition of the remplissage procedure combined with Bankart repair for treatment of large Hill-Sachs lesions had no statistically significant effect on ROM or translation, but altered the kinematics of the glenohumeral joint. Thus, by addressing the humeral bone defect following an anterior shoulder dislocation, the remplissage technique with concurrent Bankart repair may be a relatively minimally invasive option for converting engaging Hill-Sachs lesions to non-engaging and promoting shoulder stability, though further biomechanical and clinical studies are warranted. JF - Knee Surgery, Sports Traumatology, Arthroscopy AU - Argintar, Evan AU - Heckmann, Nathanael AU - Wang, Lawrence AU - Tibone, James E AU - Lee, Thay Q AD - Department of Orthopaedic Surgery, The University of Southern California, Los Angeles, CA, USA, tqlee@va.gov Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 585 EP - 592 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 24 IS - 2 SN - 0942-2056, 0942-2056 KW - Physical Education Index KW - Kinematics KW - Statistics KW - Bones KW - Flexibility KW - Surgery KW - Shoulders KW - Sports KW - Biomechanics (sports techniques) KW - Biomechanics KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768577497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.atitle=The+biomechanical+effect+of+shoulder+remplissage+combined+with+Bankart+repair+for+the+treatment+of+engaging+Hill-Sachs+lesions&rft.au=Argintar%2C+Evan%3BHeckmann%2C+Nathanael%3BWang%2C+Lawrence%3BTibone%2C+James+E%3BLee%2C+Thay+Q&rft.aulast=Argintar&rft.aufirst=Evan&rft.date=2016-02-01&rft.volume=24&rft.issue=2&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.issn=09422056&rft_id=info:doi/10.1007%2Fs00167-014-3092-4 LA - English DB - Physical Education Index N1 - Date revised - 2016-02-01 N1 - Number of references - 32 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Kinematics; Bones; Statistics; Surgery; Flexibility; Shoulders; Biomechanics (sports techniques); Sports; Biomechanics DO - http://dx.doi.org/10.1007/s00167-014-3092-4 ER - TY - JOUR T1 - Biomechanical comparison of the Latarjet procedure with and without a coracoid bone block AN - 1768576351; PQ0002649512 AB - Purpose: The aim of this study was to biomechanically evaluate the Latarjet procedure, with and without a bone block, on glenohumeral range of motion, translation, and kinematics after creation of a bony Bankart lesion. Methods: Eight cadaveric shoulders were tested for range of motion, translation, and kinematics in 90 degree shoulder abduction in both the scapular and coronal planes with the following conditions: intact, Bankart lesion with 20 % glenoid bone loss, Latarjet procedure and soft tissue only conjoined tendon transfer. Results: There was a significant increase in range of motion in both the scapular and coronal planes with both the Latarjet and conjoined tendon transfer compared to the intact state. The Latarjet procedure restored anterior and inferior translation in both planes. The conjoined tendon transfer restored anterior and inferior translation at lower translational loads, but not with higher loads. Both reconstructions shifted the humeral head apex posteriorly in external rotation. Conclusions: The increase in range of motion suggests that the Latarjet procedure does not initially over-constrain the joint. At higher loads, there was improved stability with the Latarjet procedure compared to the conjoint tendon transfer. Both Latarjet and conjoined tendon transfer procedures alter normal joint kinematics by shifting the humeral head apex posteriorly in external rotation. JF - Knee Surgery, Sports Traumatology, Arthroscopy AU - Barrett Payne, W AU - Kleiner, Matthew T AU - McGarry, Michelle H AU - Tibone, James E AU - Lee, Thay Q AD - Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, tqlee@med.va.gov Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 513 EP - 520 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 24 IS - 2 SN - 0942-2056, 0942-2056 KW - Physical Education Index KW - Kinematics KW - Bones KW - Flexibility KW - Surgery KW - Work load KW - Shoulders KW - Sports KW - Tendons KW - Joints KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768576351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.atitle=Biomechanical+comparison+of+the+Latarjet+procedure+with+and+without+a+coracoid+bone+block&rft.au=Barrett+Payne%2C+W%3BKleiner%2C+Matthew+T%3BMcGarry%2C+Michelle+H%3BTibone%2C+James+E%3BLee%2C+Thay+Q&rft.aulast=Barrett+Payne&rft.aufirst=W&rft.date=2016-02-01&rft.volume=24&rft.issue=2&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.issn=09422056&rft_id=info:doi/10.1007%2Fs00167-015-3885-0 LA - English DB - Physical Education Index N1 - Date revised - 2016-02-01 N1 - Number of references - 35 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Kinematics; Bones; Surgery; Flexibility; Shoulders; Work load; Sports; Tendons; Joints DO - http://dx.doi.org/10.1007/s00167-015-3885-0 ER - TY - JOUR T1 - Exposing a beta -Lactamase "Twist": the Mechanistic Basis for the High Level of Ceftazidime Resistance in the C69F Variant of the Burkholderia pseudomallei PenI beta -Lactamase AN - 1768571872; PQ0002688452 AB - Around the world, Burkholderia spp. are emerging as pathogens highly resistant to beta -lactam antibiotics, especially ceftazidime. Clinical variants of Burkholderia pseudomallei possessing the class A beta -lactamase PenI with substitutions at positions C69 and P167 are known to demonstrate ceftazidime resistance. However, the biochemical basis for ceftazidime resistance in class A beta -lactamases in B. pseudomallei is largely undefined. Here, we performed site saturation mutagenesis of the C69 position and investigated the kinetic properties of the C69F variant of PenI from B. pseudomallei that results in a high level of ceftazidime resistance (2 to 64 mg/liter) when expressed in Escherichia coli. Surprisingly, quantitative immunoblotting showed that the steady-state protein levels of the C69F variant beta -lactamase were similar to 4-fold lower than those of wild-type PenI (0.76 fg of protein/cell versus 4.1 fg of protein/cell, respectively). However, growth in the presence of ceftazidime increases the relative amount of the C69F variant to greater than wild-type PenI levels. The C69F variant exhibits a branched kinetic mechanism for ceftazidime hydrolysis, suggesting there are two different conformations of the enzyme. When incubated with an anti-PenI antibody, one conformation of the C69F variant rapidly hydrolyzes ceftazidime and most likely contributes to the higher levels of ceftazidime resistance observed in cell-based assays. Molecular dynamics simulations suggest that the electrostatic characteristics of the oxyanion hole are altered in the C69F variant. When ceftazidime was positioned in the active site, the C69F variant is predicted to form a greater number of hydrogen-bonding interactions than PenI with ceftazidime. In conclusion, we propose "a new twist" for enhanced ceftazidime resistance mediated by the C69F variant of the PenI beta -lactamase based on conformational changes in the C69F variant. Our findings explain the biochemical basis of ceftazidime resistance in B. pseudomallei, a pathogen of considerable importance, and suggest that the full repertoire of conformational states of a beta -lactamase profoundly affects beta -lactam resistance. JF - Antimicrobial Agents & Chemotherapy AU - Papp-Wallace, Krisztina M AU - Becka, Scott A AU - Taracila, Magdalena A AU - Winkler, Marisa L AU - Gatta, Julian A AU - Rholl, Drew A AU - Schweizer, Herbert P AU - Bonomo, Robert A AD - << + $0, robert.bonomo@va.gov. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 777 EP - 788 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 60 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Burkholderia pseudomallei KW - Immunoblotting KW - beta -Lactamase KW - Enzymes KW - Pathogens KW - Penis KW - Hydrolysis KW - Ceftazidime KW - Antibodies KW - saturation mutagenesis KW - Kinetics KW - beta -Lactam antibiotics KW - Escherichia coli KW - A 01340:Antibiotics & Antimicrobials KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768571872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Exposing+a+beta+-Lactamase+%22Twist%22%3A+the+Mechanistic+Basis+for+the+High+Level+of+Ceftazidime+Resistance+in+the+C69F+Variant+of+the+Burkholderia+pseudomallei+PenI+beta+-Lactamase&rft.au=Papp-Wallace%2C+Krisztina+M%3BBecka%2C+Scott+A%3BTaracila%2C+Magdalena+A%3BWinkler%2C+Marisa+L%3BGatta%2C+Julian+A%3BRholl%2C+Drew+A%3BSchweizer%2C+Herbert+P%3BBonomo%2C+Robert+A&rft.aulast=Papp-Wallace&rft.aufirst=Krisztina&rft.date=2016-02-01&rft.volume=60&rft.issue=2&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.02073-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 43 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Ceftazidime; Immunoblotting; saturation mutagenesis; Antibodies; beta -Lactamase; Kinetics; beta -Lactam antibiotics; Enzymes; Pathogens; Hydrolysis; Penis; Burkholderia pseudomallei; Escherichia coli DO - http://dx.doi.org/10.1128/AAC.02073-15 ER - TY - JOUR T1 - Biomechanical comparison of the modified Bristow procedure with and without capsular repair AN - 1768569532; PQ0002649501 AB - The Bristow procedure has become an effective surgical option for recurrent anterior instability of the shoulder; however, there is no consensus on whether a capsule repair following a Bristow procedure is necessary to restore glenohumeral stability. The purpose of this study was to evaluate whether capsular repair with a modified Bristow procedure affects rotational range of motion and glenohumeral stability. Rotational range of motion, glenohumeral translation and kinematics were measured in eight cadaveric shoulders in 90 degree shoulder abduction in the scapular and coronal planes for four conditions: intact, 20 % bony Bankart lesion, modified Bristow without capsular repair and modified Bristow with capsular repair. Creation of the bony Bankart led to a significant increase in total range of motion and anterior-inferior translation compared to the intact shoulder. The modified Bristow procedure significantly decreased anterior-inferior translation compared to the bony Bankart but did not decrease total range of motion. Capsular repair decreased total range of motion in the scapular and coronal planes and altered normal glenohumeral kinematics in external rotation positions. Repairing the capsule in a Bristow procedure decreases rotational range of motion yet does not offer any added anterior-inferior translational stability. Capsular repair also significantly alters normal glenohumeral kinematics. Capsule repair with a Bristow procedure may not add additional glenohumeral stability in positions of apprehension and may potentially over constrain the joint and cause altered kinematics. JF - Knee Surgery, Sports Traumatology, Arthroscopy AU - Abdulian, Michael H AU - Kephart, Curtis J AU - McGarry, Michelle H AU - Tibone, James E AU - Lee, Thay Q AD - Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, tqlee@va.gov Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 489 EP - 495 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 24 IS - 2 SN - 0942-2056, 0942-2056 KW - Physical Education Index KW - Kinematics KW - Measurement KW - Flexibility KW - Surgery KW - Shoulders KW - Stability KW - Sports KW - Biomechanics KW - Joints KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768569532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.atitle=Biomechanical+comparison+of+the+modified+Bristow+procedure+with+and+without+capsular+repair&rft.au=Abdulian%2C+Michael+H%3BKephart%2C+Curtis+J%3BMcGarry%2C+Michelle+H%3BTibone%2C+James+E%3BLee%2C+Thay+Q&rft.aulast=Abdulian&rft.aufirst=Michael&rft.date=2016-02-01&rft.volume=24&rft.issue=2&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.issn=09422056&rft_id=info:doi/10.1007%2Fs00167-015-3915-y LA - English DB - Physical Education Index N1 - Date revised - 2016-02-01 N1 - Number of references - 18 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Measurement; Kinematics; Surgery; Flexibility; Shoulders; Sports; Stability; Biomechanics; Joints DO - http://dx.doi.org/10.1007/s00167-015-3915-y ER - TY - JOUR T1 - The effect of defect orientation and size on glenohumeral instability: a biomechanical analysis AN - 1768569345; PQ0002649504 AB - The purpose of this study was to determine the relationship between bony stability and percentage of anterior glenoid bone loss and the effect of bone loss orientation. Twelve cadaveric shoulders were studied. Glenoid bone defects were simulated in two different osteotomy angles: 0 degree and 45 degree to the superoinferior (SI) axis of the glenoid. The force and displacement required for dislocation were measured under two compressive forces of 40 and 60N. Testing was performed for the intact glenoid and glenoid defects of 2, 4, 6, 8, and 10 mm from the anterior margin. The maximum force for dislocation with the 2-mm glenoid defect was significantly decreased compared with intact glenoid (p = 0.01), and this force also significantly decreased with each increase in defect size (p < 0.05). The dislocation force for 45 degree osteotomy was significantly higher than that for 0 degree osteotomy for all defect widths up to 8 mm with 40N compression and 6 mm with 60N compression (p < 0.001). The displacement at dislocation did not significantly decrease until the 8-mm defect with the 45 degree osteotomy but significantly decreased with the 4-mm defect with the 0 degree osteotomy. The required force for dislocation with 60N compression was significantly higher than that with 40N compression for all osteotomy sizes and orientations. The decrease in stability even with glenoid bone loss as small as 2 mm or 7.5 % of the glenoid width suggests that bony restoration is recommended whenever any bone loss exists. Bone defects parallel to SI axis may be more susceptible to recurrent instability, and shoulder muscle strengthening exercises may increase glenohumeral compressive force and thus improve glenohumeral stability. Bony restoration is recommended whenever bone loss exists even with small bone fragments particularly those in line with the superior-inferior axis of the glenoid. JF - Knee Surgery, Sports Traumatology, Arthroscopy AU - Shin, Sang-Jin AU - Ko, Young Won AU - Scott, Jonathan AU - McGarry, Michelle H AU - Lee, Thay Q AD - Department of Orthopaedic Surgery, Ewha Womans University, Seoul, Korea, tqlee@va.gov Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 533 EP - 539 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 24 IS - 2 SN - 0942-2056, 0942-2056 KW - Physical Education Index KW - Measurement KW - Bones KW - Dislocations KW - Surgery KW - Analysis KW - Muscles KW - Shoulders KW - Stability KW - Sports KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768569345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.atitle=The+effect+of+defect+orientation+and+size+on+glenohumeral+instability%3A+a+biomechanical+analysis&rft.au=Shin%2C+Sang-Jin%3BKo%2C+Young+Won%3BScott%2C+Jonathan%3BMcGarry%2C+Michelle+H%3BLee%2C+Thay+Q&rft.aulast=Shin&rft.aufirst=Sang-Jin&rft.date=2016-02-01&rft.volume=24&rft.issue=2&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.issn=09422056&rft_id=info:doi/10.1007%2Fs00167-015-3943-7 LA - English DB - Physical Education Index N1 - Date revised - 2016-02-01 N1 - Number of references - 30 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Measurement; Bones; Dislocations; Analysis; Surgery; Muscles; Shoulders; Sports; Stability DO - http://dx.doi.org/10.1007/s00167-015-3943-7 ER - TY - JOUR T1 - Intra-arterial administration improves temozolomide delivery and efficacy in a model of intracerebral metastasis, but has unexpected brain toxicity. AN - 1761472208; 26694547 AB - We tested the hypothesis that intra-arterial (IA) infusion of temozolomide into the internal carotid artery would safely improve drug delivery to brain and enhance chemotherapy efficacy in a chemosensitive rat brain tumor model. Quantitative autoradiography after 25 µCi (14)C-temozolomide was given by oral, intravenous, or IA route of administration, or IA with osmotic blood-brain barrier disruption (BBBD) (n = 5-7 per group) showed that both IA and IA/BBBD administration increased drug delivery in tumor by over threefold compared to normal brain (P < 0.02), and also significantly elevated delivery throughout the infused right hemisphere. Temozolomide (20 mg/kg; ~150 mg/m(2)) increased median survival when given by oral (25.5 days), intravenous (25.5 days), or IA (33 days) route of administration, compared to 17.5 days in untreated controls (n = 8 per group; overall P < 0.0001). Survival time after IA temozolomide was significantly longer than all other groups (P < 0.01 for all comparisons). BBBD temozolomide was toxic in the efficacy study, but there was no evidence of symptomatic neurotoxicity in rats given IA temozolomide. After these promising animal results, a 49 year old male with glioblastoma multiforme who failed all standard therapy received temozolomide 100 mg/m(2) IA. Upon initiation of the second course of IA infusion the patient had increased heart rate, blood pressure, and rash, and the procedure was terminated without sequelae. Follow up IA infusion of temozolomide diluent in normal rats showed damaged cerebrovasculature as determined by dye leakage. These results demonstrate that IA infusion of temozolomide was toxic, with or without BBBD. We conclude that under the current formulation temozolomide is not safe for IA infusion in patients. JF - Journal of neuro-oncology AU - Muldoon, Leslie L AU - Pagel, Michael A AU - Netto, Joao Prola AU - Neuwelt, Edward A AD - Department of Neurology, Oregon Health & Sciences University, L603; 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA. ; Veterans Administration Medical Center, Portland, OR, 97239, USA. ; Department of Neurology, Oregon Health & Sciences University, L603; 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA. neuwelte@ohsu.edu. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 447 EP - 454 VL - 126 IS - 3 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Dacarbazine KW - 7GR28W0FJI KW - temozolomide KW - YF1K15M17Y KW - Index Medicus KW - Case study KW - Chemotherapy KW - Intra-arterial infusion KW - Animal model KW - Rats KW - Animals KW - Tumor Cells, Cultured KW - Rats, Nude KW - Injections, Intra-Arterial KW - Humans KW - Xenograft Model Antitumor Assays KW - Antineoplastic Agents, Alkylating -- adverse effects KW - Middle Aged KW - Antineoplastic Agents, Alkylating -- administration & dosage KW - Male KW - Drug Delivery Systems KW - Small Cell Lung Carcinoma -- drug therapy KW - Lung Neoplasms -- drug therapy KW - Neurotoxicity Syndromes -- etiology KW - Dacarbazine -- adverse effects KW - Brain Neoplasms -- secondary KW - Blood-Brain Barrier -- drug effects KW - Brain Neoplasms -- drug therapy KW - Small Cell Lung Carcinoma -- pathology KW - Dacarbazine -- analogs & derivatives KW - Dacarbazine -- administration & dosage KW - Neurotoxicity Syndromes -- pathology KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761472208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuro-oncology&rft.atitle=Intra-arterial+administration+improves+temozolomide+delivery+and+efficacy+in+a+model+of+intracerebral+metastasis%2C+but+has+unexpected+brain+toxicity.&rft.au=Muldoon%2C+Leslie+L%3BPagel%2C+Michael+A%3BNetto%2C+Joao+Prola%3BNeuwelt%2C+Edward+A&rft.aulast=Muldoon&rft.aufirst=Leslie&rft.date=2016-02-01&rft.volume=126&rft.issue=3&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuro-oncology&rft.issn=1573-7373&rft_id=info:doi/10.1007%2Fs11060-015-2000-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-01 N1 - Date created - 2016-01-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s11060-015-2000-1 ER - TY - JOUR T1 - Counseling patients with asthma and allergy about electronic cigarettes: an evidence-based approach. AN - 1761460132; 26522253 AB - To provide an evidence-based review of common safety concerns and emerging potential benefits deriving from the regular use of electronic cigarettes (ECs) and thus improve counseling between physicians and their patients with asthma and allergy using or intending to use ECs. Peer-reviewed articles from the National Center for Biotechnology Information's PubMed about ECs, risk reduction, and harm reversal were appraised. Keywords used in the search were smoking cessation, electronic cigarette, counseling, asthma, allergy, nicotine, tobacco harm reduction, and harm reversal. Vapor toxicology is far less problematic compared with combustible cigarettes, with exclusive EC users having substantial lower risk of exposure to tobacco smoke toxicants and carcinogens compared with cigarette smokers. Moreover, there is emerging evidence that switching to regular EC use could produce significant respiratory health gains. Inaccurate and inconsistent information about EC safety and efficacy, tobacco harm reduction, and nicotine toxicity is being offered to smokers and EC users. In particular, most health care professionals cannot communicate a clear and consistent message to their patients with respiratory problems and allergy who use or intend to use ECs. Therefore, it is important for the medical community to take an active role in considering all the pathways available to a smoking patient and recommend those that provide the greatest probability of eliminating exposure to tobacco smoke, including ECs. Copyright © 2016 American College of Allergy, Asthma & Immunology. All rights reserved. JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology AU - Polosa, Riccardo AU - Campagna, Davide AU - Sands, Mark F AD - Centro per la Prevenzione e Cura del Tabagismo, Azienda Ospedaliero-Universitaria "Policlinico V. Emanuele", Catania, Italy; Dipartimento di Medicina Clinica e Sperimentale, Università di Catania, Catania, Italy; UOC di Medicina Interna e d'Urgenza, Azienda Ospedaliero-Universitaria "Policlinico V. Emanuele", Catania, Italy. Electronic address: polosa@unict.it. ; Centro per la Prevenzione e Cura del Tabagismo, Azienda Ospedaliero-Universitaria "Policlinico V. Emanuele", Catania, Italy; Dipartimento di Medicina Clinica e Sperimentale, Università di Catania, Catania, Italy; UOC di Medicina Interna e d'Urgenza, Azienda Ospedaliero-Universitaria "Policlinico V. Emanuele", Catania, Italy. ; Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York; The Veterans Administration Healthcare System of Western New York, Buffalo, New York. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 106 EP - 111 VL - 116 IS - 2 KW - Index Medicus KW - Evidence-Based Medicine KW - Humans KW - Smoking Cessation KW - Smoking -- adverse effects KW - Counseling KW - Hypersensitivity KW - Electronic Cigarettes -- adverse effects KW - Physician-Patient Relations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761460132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+allergy%2C+asthma+%26+immunology+%3A+official+publication+of+the+American+College+of+Allergy%2C+Asthma%2C+%26+Immunology&rft.atitle=Counseling+patients+with+asthma+and+allergy+about+electronic+cigarettes%3A+an+evidence-based+approach.&rft.au=Polosa%2C+Riccardo%3BCampagna%2C+Davide%3BSands%2C+Mark+F&rft.aulast=Polosa&rft.aufirst=Riccardo&rft.date=2016-02-01&rft.volume=116&rft.issue=2&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Annals+of+allergy%2C+asthma+%26+immunology+%3A+official+publication+of+the+American+College+of+Allergy%2C+Asthma%2C+%26+Immunology&rft.issn=1534-4436&rft_id=info:doi/10.1016%2Fj.anai.2015.10.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-02 N1 - Date created - 2016-01-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment In: Ann Allergy Asthma Immunol. 2016 Feb;116(2):89-90 [26815701] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.anai.2015.10.012 ER - TY - JOUR T1 - Fatal acute cardiac vasculopathy during cisplatin-gemcitabine-bevacizumab (CGB) chemotherapy for advanced urothelial carcinoma. AN - 1760886762; 26423690 AB - Bladder cancer (BC) accounts for ∼14,680 deaths annually in the U.S. The prognosis of advanced disease remains dismal with current therapies. A phase III intergroup trial for metastatic BC adding bevacizumab to first-line cisplatin-gemcitabine chemotherapy (GCB regimen) is currently ongoing. We report the clinical-pathologic findings of a patient who developed fatal acute cardiac microvascular toxicity while receiving this regimen. A 66 year old man consulted for epigastric pain, nausea, intermittent diarrhea and lightheadedness two weeks after receiving the first cycle of GCB chemotherapy for metastatic BC. Physical evaluation, laboratory studies and electrocardiogram (EKG) were within normal limits except for marked thrombocytopenia that was attributed to his recent chemotherapy. The patient was admitted for observation, rehydrated and started on a proton pump inhibitor. The following day, however, he experienced sudden severe chest and right upper quadrant pain. EKG showed tachycardia, ST elevations in leads V2 and V3, laboratory analyses revealed marked elevation of cardiac troponin I, and an echocardiogram showed a markedly reduced ejection fraction of 10-20%, consistent with rapidly progressive cardiogenic shock. Emergent cardiac catheterization showed no significant coronary artery disease. Sepsis work-up was negative. He became progressively hypotensive, developed multi-organ failure, and died 48 h after admission. Postmortem examination showed diffuse microvasculopathy and changes due to global hypoperfusion of 12-48 h evolution. We present the first case of acute, fatal cardiac failure due to microvasculopathy most consistent with bevacizumab-associated toxicity. The findings are discussed in light of the existing literature. Published by Elsevier Ltd. JF - Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy AU - Gruenberg, Jessica AU - Manivel, J Carlos AU - Gupta, Pankaj AU - Dykoski, Richard AU - Mesa, Hector AD - Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, 420 Delaware St. SE, Minneapolis, MN 55455, USA. Electronic address: grue0048@umn.edu. ; Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, 420 Delaware St. SE, Minneapolis, MN 55455, USA; Department of Pathology, Minneapolis VA Health Care System, One Veterans Drive, Minneapolis, MN 55417, USA. Electronic address: Juan.Manivel@va.gov. ; Department of Hematology & Oncology, University of Minnesota School of Medicine, 420 Delaware St. SE, Minneapolis, MN 55455, USA; Department of Hematology & Oncology, Minneapolis VA Health Care System, One Veterans Drive, Minneapolis, MN 55417, USA. Electronic address: Pankaj.Gupta@va.gov. ; Department of Pathology, Minneapolis VA Health Care System, One Veterans Drive, Minneapolis, MN 55417, USA. Electronic address: Richard.Dykoski@va.gov. ; Department of Pathology, Minneapolis VA Health Care System, One Veterans Drive, Minneapolis, MN 55417, USA. Electronic address: Hector.Mesa@va.gov. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 112 EP - 116 VL - 22 IS - 2 KW - Deoxycytidine KW - 0W860991D6 KW - Bevacizumab KW - 2S9ZZM9Q9V KW - gemcitabine KW - B76N6SBZ8R KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Bladder cancer KW - Chemotherapy KW - Cardiotoxicity KW - Gemcitabine KW - Acute Disease KW - Bevacizumab -- adverse effects KW - Deoxycytidine -- adverse effects KW - Humans KW - Deoxycytidine -- analogs & derivatives KW - Deoxycytidine -- administration & dosage KW - Aged KW - Cisplatin -- adverse effects KW - Bevacizumab -- administration & dosage KW - Male KW - Cisplatin -- administration & dosage KW - Urothelium -- drug effects KW - Heart Diseases -- chemically induced KW - Carcinoma -- drug therapy KW - Urologic Neoplasms -- drug therapy KW - Heart Diseases -- mortality KW - Urologic Neoplasms -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Carcinoma -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760886762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+infection+and+chemotherapy+%3A+official+journal+of+the+Japan+Society+of+Chemotherapy&rft.atitle=Fatal+acute+cardiac+vasculopathy+during+cisplatin-gemcitabine-bevacizumab+%28CGB%29+chemotherapy+for+advanced+urothelial+carcinoma.&rft.au=Gruenberg%2C+Jessica%3BManivel%2C+J+Carlos%3BGupta%2C+Pankaj%3BDykoski%2C+Richard%3BMesa%2C+Hector&rft.aulast=Gruenberg&rft.aufirst=Jessica&rft.date=2016-02-01&rft.volume=22&rft.issue=2&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Journal+of+infection+and+chemotherapy+%3A+official+journal+of+the+Japan+Society+of+Chemotherapy&rft.issn=1437-7780&rft_id=info:doi/10.1016%2Fj.jiac.2015.08.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-20 N1 - Date created - 2016-01-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jiac.2015.08.015 ER - TY - JOUR T1 - BRAF inhibition for advanced locoregional BRAF V600E mutant melanoma: a potential neoadjuvant strategy. AN - 1754523526; 26731560 AB - Selective BRAF inhibitors (BRAFi) yield objective responses in 50% of patients with metastatic BRAF V600E mutant melanoma. Adding an MEK inhibitor increases this response rate to 70%. Limited data are available on the outcomes of unresectable stage III patients, and it remains unclear whether BRAF-targeted therapy can be utilized as a neoadjuvant strategy. Data on patients with advanced locoregional BRAF V600E mutant melanoma treated with BRAF-targeted therapy at Moffitt Cancer Center were analyzed to determine response rates, subsequent resection rates after tumor downsizing, pathologic responses, and patient survival. Fifteen patients with locoregional disease treated with BRAF-targeted therapy, either BRAFi alone (vemurafenib; 11 patients) or a combination of BRAFi and an MEK inhibitor (dabrafenib plus trametinib or placebo; four patients), were identified. The median age was 50 years; the median follow-up was 25.4 months. The median BRAF-targeted therapy treatment duration was 6.0 months (range 1.2-29.4 months). Response Evaluation Criteria In Solid Tumors-based evaluation demonstrated objective response in 11 patients (73.3%). Six patients underwent resection of the remaining disease after therapy. Pathological analysis showed complete pathologic response (n=2), partial pathologic response (n=2), or no pathologic response (n=2). Four of six patients undergoing surgery have been alive for more than 2 years, including three patients currently free from active disease. No complications attributable to BRAF-targeted therapy were observed in the perioperative period. Dose reduction or discontinuation because of toxicities occurred in 10/15 patients. Neoadjuvant BRAF-targeted therapy may be effective in advanced locoregional BRAF V600E mutant melanoma patients in increasing resectability, yielding pathological responses, and achieving prolonged survival. JF - Melanoma research AU - Sloot, Sarah AU - Zager, Jonathan S AU - Kudchadkar, Ragini R AU - Messina, Jane L AU - Benedict, Jacob J AU - Gonzalez, Ricardo J AU - DeConti, Ronald AU - Turner, Leslie M AU - McCardle, Timothy AU - Smalley, Keiran S M AU - Weber, Jeffrey S AU - Sondak, Vernon K AU - Gibney, Geoffrey T AD - Departments of aCutaneous Oncology bAnatomic Pathology, Moffitt Cancer Center Departments of cOncologic Sciences dSurgery, University of South Florida Morsani College of Medicine eDepartment of Pathology, Veterans Administration, Tampa, Florida fDepartment of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia gGeorgetown-Lombardi Comprehensive Cancer Center and Department of Medicine, Medstar-Georgetown University Hospital, Washington, DC, USA hUniversity of Groningen, Department of Surgical Oncology, University Medical Center Groningen, The Netherlands. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 83 EP - 87 VL - 26 IS - 1 KW - Imidazoles KW - 0 KW - Indoles KW - Oximes KW - Protein Kinase Inhibitors KW - Pyridones KW - Pyrimidinones KW - Sulfonamides KW - vemurafenib KW - 207SMY3FQT KW - trametinib KW - 33E86K87QN KW - Glutamic Acid KW - 3KX376GY7L KW - BRAF protein, human KW - EC 2.7.11.1 KW - Proto-Oncogene Proteins B-raf KW - Valine KW - HG18B9YRS7 KW - dabrafenib KW - QGP4HA4G1B KW - Index Medicus KW - Pyrimidinones -- administration & dosage KW - Oximes -- administration & dosage KW - Humans KW - Imidazoles -- administration & dosage KW - Protein Kinase Inhibitors -- administration & dosage KW - Neoadjuvant Therapy KW - Retrospective Studies KW - Disease Progression KW - Molecular Targeted Therapy KW - Valine -- genetics KW - Sulfonamides -- administration & dosage KW - Mutation, Missense KW - Glutamic Acid -- genetics KW - Pyridones -- administration & dosage KW - Treatment Outcome KW - Indoles -- administration & dosage KW - Follow-Up Studies KW - Middle Aged KW - Amino Acid Substitution KW - Female KW - Male KW - Skin Neoplasms -- genetics KW - Skin Neoplasms -- drug therapy KW - Melanoma -- pathology KW - Melanoma -- genetics KW - Melanoma -- mortality KW - Proto-Oncogene Proteins B-raf -- antagonists & inhibitors KW - Melanoma -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Skin Neoplasms -- mortality KW - Proto-Oncogene Proteins B-raf -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1754523526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Melanoma+research&rft.atitle=BRAF+inhibition+for+advanced+locoregional+BRAF+V600E+mutant+melanoma%3A+a+potential+neoadjuvant+strategy.&rft.au=Sloot%2C+Sarah%3BZager%2C+Jonathan+S%3BKudchadkar%2C+Ragini+R%3BMessina%2C+Jane+L%3BBenedict%2C+Jacob+J%3BGonzalez%2C+Ricardo+J%3BDeConti%2C+Ronald%3BTurner%2C+Leslie+M%3BMcCardle%2C+Timothy%3BSmalley%2C+Keiran+S+M%3BWeber%2C+Jeffrey+S%3BSondak%2C+Vernon+K%3BGibney%2C+Geoffrey+T&rft.aulast=Sloot&rft.aufirst=Sarah&rft.date=2016-02-01&rft.volume=26&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Melanoma+research&rft.issn=1473-5636&rft_id=info:doi/10.1097%2FCMR.0000000000000214 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-19 N1 - Date created - 2016-01-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/CMR.0000000000000214 ER - TY - JOUR T1 - Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine. AN - 1750000796; 26362360 AB - Depression is a common co-morbid condition most often observed in subjects with mild cognitive impairment (MCI) and during the early stages of Alzheimer's disease (AD). Dysfunction of the central noradrenergic nervous system is an important component in depression. In AD, locus coeruleus (LC) noradrenergic neurons are significantly reduced pathologically and the reduction of LC neurons is hypothesized to begin very early in the progression of the disorder; however, it is not known if dysfunction of the noradrenergic system due to early LC neuronal loss is involved in mediating depression in early AD. Therefore, the purpose of this study was to determine in an animal model if a loss of noradrenergic LC neurons results in depressive-like behavior. The LC noradrenergic neuronal population was reduced by the bilateral administration of the neurotoxin 6-hydroxydopamine (6-OHDA) directly into the LC. Forced swim test (FST) was performed three weeks after the administration of 6-OHDA (5, 10 and 14 μg/μl), animals administered the 5 μg/μl of 6-OHDA demonstrated a significant increase in immobility, indicating depressive-like behavior. This increase in immobility at the 5 μg/μl dose was observed with a minimal loss of LC noradrenergic neurons as compared to LC neuronal loss observed at 10 and 14 μg/μl dose. A significant positive correlation between the number of surviving LC neurons after 6-OHDA and FST immobile time was observed, suggesting that in animals with a minimal loss of LC neurons (or a greater number of surviving LC neurons) following 6-OHDA demonstrated depressive-like behavior. As the 6-OHDA-induced loss of LC neurons is increased, the time spent immobile is reduced. Depressive-like behavior was also observed with the 5 μg/μl dose of 6-OHDA with a second behavior test, sucrose consumption. FST increased immobility following 6-OHDA (5 μg/μl) was reversed by the administration of a single dose of L-1-3-4-dihydroxyphenylalanine (DOPA) or l-threo-3,4-dihydroxyphenylserine (DOPS) prior to behavioral assessment. Surviving LC neurons 3 weeks after 6-OHDA (5 μg/μl) demonstrated compensatory changes of increased firing frequency, a more irregular firing pattern, and a higher percentage of cells firing in bursts. These results indicate that depressive-like behavior in mice is observed following the administration of 6-OHDA and the loss of LC noradrenergic neurons; however, the depressive-like behavior correlates positively with the number of surviving LC neurons with 6-OHDA administration. This data suggests the depression observed in MCI subjects and in the early stages of AD may due to the hypothesized early, minimal loss of LC neurons with remaining LC neurons being more active than normal. Published by Elsevier Ltd. JF - Neuropharmacology AU - Szot, Patricia AU - Franklin, Allyn AU - Miguelez, Cristina AU - Wang, Yangqing AU - Vidaurrazaga, Igor AU - Ugedo, Luisa AU - Sikkema, Carl AU - Wilkinson, Charles W AU - Raskind, Murray A AD - Mental Illness Research, Education and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Electronic address: szot@uw.edu. ; Mental Illness Research, Education and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA, USA. ; Department of Pharmacology, University of the Basque Country, UPV/EHU, Leioa, Spain; Department of Pharmacology, University of the Basque Country, UPV/EHU, Vitoria-Gasteiz, Spain. ; Department of Pharmacology, University of the Basque Country, UPV/EHU, Leioa, Spain. ; Geriatric Research, Education and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA, USA. ; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA; Geriatric Research, Education and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA, USA. ; Mental Illness Research, Education and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 76 EP - 86 VL - 101 KW - Adrenergic Agents KW - 0 KW - Catecholamines KW - Dopamine Agents KW - Phenazines KW - dihydroxyphenoxazine KW - Levodopa KW - 46627O600J KW - Sucrose KW - 57-50-1 KW - Oxidopamine KW - 8HW4YBZ748 KW - Index Medicus KW - Depression KW - Locus coeruleus KW - 6-Hydroxydopamine KW - Forced swim test KW - Electrophysiology KW - Levodopa -- pharmacology KW - Swimming -- psychology KW - Animals KW - Phenazines -- pharmacology KW - Food Preferences KW - Dose-Response Relationship, Drug KW - Dopamine Agents -- pharmacology KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Mice KW - Sucrose -- administration & dosage KW - Time Factors KW - Male KW - Locus Coeruleus -- pathology KW - Adrenergic Agents -- toxicity KW - Depression -- pathology KW - Catecholamines -- metabolism KW - Oxidopamine -- toxicity KW - Neurons -- drug effects KW - Neurons -- physiology KW - Action Potentials -- drug effects KW - Depression -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1750000796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Depressive-like+behavior+observed+with+a+minimal+loss+of+locus+coeruleus+%28LC%29+neurons+following+administration+of+6-hydroxydopamine+is+associated+with+electrophysiological+changes+and+reversed+with+precursors+of+norepinephrine.&rft.au=Szot%2C+Patricia%3BFranklin%2C+Allyn%3BMiguelez%2C+Cristina%3BWang%2C+Yangqing%3BVidaurrazaga%2C+Igor%3BUgedo%2C+Luisa%3BSikkema%2C+Carl%3BWilkinson%2C+Charles+W%3BRaskind%2C+Murray+A&rft.aulast=Szot&rft.aufirst=Patricia&rft.date=2016-02-01&rft.volume=101&rft.issue=&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=1873-7064&rft_id=info:doi/10.1016%2Fj.neuropharm.2015.09.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-22 N1 - Date created - 2015-12-16 N1 - Date revised - 2017-02-02 N1 - SuppNotes - Cited By: Eur J Pharmacol. 1978 Oct 1;51(3):291-4 [568552] Proc Natl Acad Sci U S A. 2004 May 25;101(21):8186-91 [15148402] J Neurol Sci. 1981 Mar;49(3):419-28 [7217992] Neurology. 1982 Feb;32(2):164-8 [7198741] Neurosci Lett. 1986 Mar 14;64(3):247-52 [3960404] Neuropharmacology. 1986 Apr;25(4):385-9 [3012399] Neuroscience. 1986 Jun;18(2):291-306 [3736860] Neuroscience. 1986 Jun;18(2):307-19 [3736861] Psychopharmacol Bull. 1986;22(3):943-9 [3797595] Ciba Found Symp. 1986;123:191-215 [3028724] Adv Exp Med Biol. 1988;245:425-40 [2906520] Neuropsychopharmacology. 1988 Dec;1(4):287-95 [2908021] Neuropharmacology. 1989 Jul;28(7):651-60 [2569689] J Comp Neurol. 1989 Sep 15;287(3):373-92 [2570794] Ann Neurol. 1992 Nov;32(5):667-76 [1449247] Naunyn Schmiedebergs Arch Pharmacol. 1997 Feb;355(2):267-72 [9050022] Eur J Pharmacol. 1997 Oct 22;337(2-3):115-23 [9430405] Psychopharmacology (Berl). 1998 Apr;136(3):299-303 [9566816] J Neurochem. 1998 Jun;70(6):2468-76 [9603211] J Neurosci. 2006 Jan 11;26(2):467-78 [16407544] Int Psychogeriatr. 2007 Feb;19(1):125-35 [16834811] Eur Neuropsychopharmacol. 2007 Apr;17(5):328-38 [16950604] J Affect Disord. 2008 Feb;106(1-2):169-72 [17698206] Am J Geriatr Psychiatry. 2009 Apr;17(4):308-16 [19307859] Int J Neuropsychopharmacol. 2009 Jun;12(5):627-41 [18950545] Acta Neuropathol. 2011 Feb;121(2):171-81 [21170538] Brain Res. 2011 Feb 10;1373:240-52 [21147074] Int J Neuropsychopharmacol. 2011 Mar;14(2):187-200 [20426885] Neurobiol Dis. 2011 Jun;42(3):327-40 [21310234] Acta Neuropathol. 2011 May;121(5):589-95 [21516512] Brain Res Rev. 2011 Jun 24;67(1-2):193-208 [21315760] Alzheimers Dement. 2011 Sep;7(5):532-9 [21889116] J Neuropathol Exp Neurol. 2011 Nov;70(11):960-9 [22002422] Biol Psychiatry. 2012 May 1;71(9):814-21 [22322105] Epilepsia. 2012 Jun;53 Suppl 1:61-6 [22612810] Neuroscience. 2012 Aug 2;216:143-57 [22542679] Arch Neurol. 2004 Aug;61(8):1290-3 [15313849] N Engl J Med. 1969 Feb 13;280(7):337-45 [4178641] Psychol Med. 1973 Aug;3(3):333-6 [4729193] Am J Geriatr Psychiatry. 2012 Aug;20(8):653-63 [22157280] J Alzheimers Dis. 2012;31(2):325-34 [22543849] Neurobiol Aging. 2013 Jan;34(1):286-97 [22503003] Curr Opin Neurol. 2012 Dec;25(6):708-14 [23160422] Int J Neuropsychopharmacol. 2013 Jun;16(5):1093-104 [23040084] J Alzheimers Dis. 2014;38(2):319-29 [23963290] Am J Geriatr Psychiatry. 2014 Jan;22(1):4-13.e1 [23880336] Am J Psychiatry. 2014 May;171(5):572-81 [24700290] Eur Neuropsychopharmacol. 2014 Jul;24(7):1112-22 [24582527] J Neurosci. 1999 Dec 15;19(24):10985-92 [10594079] Biol Psychiatry. 1999 Nov 1;46(9):1167-80 [10560023] Neurobiol Aging. 2015 Jan;36(1):1-11 [25444609] Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):325-30 [10618417] Neuropsychopharmacology. 2000 Feb;22(2):191-9 [10649831] Biol Psychiatry. 2001 Jan 15;49(2):117-29 [11164758] J Pharmacol Exp Ther. 2001 Aug;298(2):651-7 [11454927] Eur J Pharmacol. 2002 Feb 2;436(3):197-205 [11858799] Arch Neurol. 2003 Mar;60(3):337-41 [12633144] J Affect Disord. 2003 Apr;74(2):185-9 [12706520] Am J Psychiatry. 2003 May;160(5):857-66 [12727688] Psychopharmacology (Berl). 1979 Jun 28;64(1):95-7 [113840] N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1016/j.neuropharm.2015.09.003 ER - TY - JOUR T1 - Lamotrigine Induced Whole Body Tics: A Case Report and Literature Review. AN - 1790457977; 26537524 AB - Lamotrigine is an anticonvulsant medication that also has utility in the treatment of bipolar disorder. It has been associated with many side effects, including rashes that can progress to Stevens-Johnson syndrome or toxic epidermal necrolysis. It has also been associated with the development of motor tics, most commonly in the head, neck, and shoulders. We will now present the case of a 45-year-old woman who developed tics that involved the entire left side of her body after her dose of lamotrigine was increased from 200 mg daily (2.0 mg/kg/day) to 225 mg daily (2.3 mg/kg/day). We will review the prior cases of lamotrigine induced tics, and compare them to the circumstances surrounding our patient. We will also discuss the neurobiology of tics and make suggestions to improve the tics, based on the reported cases. JF - Current drug safety AU - Centorino, Michael B AU - Catalano, Glenn AU - Catalano, Maria C AD - Mental Health and Behavioral Sciences Service, James A. Haley Veterans Hospital, 13000 Bruce B. Downs Boulevard #116A, Tampa, Florida, FL 33612, USA. glenn.catalano@va.gov. Y1 - 2016 PY - 2016 DA - 2016 SP - 189 EP - 191 VL - 11 IS - 2 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790457977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+safety&rft.atitle=Lamotrigine+Induced+Whole+Body+Tics%3A+A+Case+Report+and+Literature+Review.&rft.au=Centorino%2C+Michael+B%3BCatalano%2C+Glenn%3BCatalano%2C+Maria+C&rft.aulast=Centorino&rft.aufirst=Michael&rft.date=2016-01-01&rft.volume=11&rft.issue=2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Current+drug+safety&rft.issn=2212-3911&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Stress Reactivity in Insomnia AN - 1789436230 AB - This study examined whether individuals with primary insomnia (PI) are more reactive to stress than good sleepers (GS). PI and GS (n = 20 per group), matched on gender and age, completed three nights of polysomnography. On the stress night, participants received a mild electric shock and were told they could receive additional shocks during the night. Saliva samples were obtained for analysis of cortisol and alpha amylase along with self-report and visual analog scales (VAS). There was very little evidence of increased stress on the stress night, compared to the baseline night. There was also no evidence of greater stress reactivity in the PI group for any sleep or for salivary measures. In the GS group, stress reactivity measured by VAS scales was positively associated with an increase in sleep latency in the experimental night on exploratory analyses. Individuals with PI did not show greater stress reactivity compared to GS. JF - Behavioral Sleep Medicine AU - Gehrman, Philip R AU - Hall, Martica AU - Barilla, Holly AU - Buysse, Daniel AU - Perlis, Michael AU - Gooneratne, Nalaka AU - Ross, Richard J AD - Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania; Philadelphia Veterans Administration Medical Center ; Sleep Medicine Institute and Department of Psychiatry, University of Pittsburgh School of Medicine ; Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania ; Division of Geriatric Medicine Perelman School of Medicine at the University of Pennsylvania ; Philadelphia Veterans Administration Medical Center; Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania Y1 - 2016///Jan/Feb PY - 2016 DA - Jan/Feb 2016 SP - 23 EP - 33 CY - Mahwah PB - Taylor & Francis Ltd. VL - 14 IS - 1 SN - 1540-2002 KW - Psychology KW - Insomnia KW - Cortisol KW - Electric shock KW - Polysomnography KW - Reactivity KW - Stress KW - Sleep UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1789436230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sleep+Medicine&rft.atitle=Stress+Reactivity+in+Insomnia&rft.au=Gehrman%2C+Philip+R%3BHall%2C+Martica%3BBarilla%2C+Holly%3BBuysse%2C+Daniel%3BPerlis%2C+Michael%3BGooneratne%2C+Nalaka%3BRoss%2C+Richard+J&rft.aulast=Gehrman&rft.aufirst=Philip&rft.date=2016-01-01&rft.volume=14&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sleep+Medicine&rft.issn=15402002&rft_id=info:doi/10.1080%2F15402002.2014.940112 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright © Taylor & Francis Group, LLC N1 - Last updated - 2016-05-19 DO - http://dx.doi.org/10.1080/15402002.2014.940112 ER - TY - JOUR T1 - Fluoroquinolone and Macrolide Exposure Predict Clostridium difficile Infection with the Highly Fluoroquinolone- and Macrolide-Resistant Epidemic C. difficile Strain BI/NAP1/027 AN - 1758247329; PQ0002452947 AB - Antibiotics have been shown to influence the risk of infection with specific Clostridium difficile strains as well as the risk of C. difficile infection (CDI). We performed a retrospective case-control study of patients infected with the epidemic BI/NAP1/027 strain in a U.S. hospital following recognition of increased CDI severity and culture of stools positive by C. difficile toxin immunoassay. Between 2005 and 2007, 72% (103/143) of patients with first-episode CDIs were infected with the BI strain by restriction endonuclease analysis (REA) typing. Most patients received multiple antibiotics within 6 weeks of CDI onset (median of 3 antibiotic classes). By multivariate analysis, fluoroquinolone and macrolide exposure was more frequent among BI cases than among non-BI-infected controls (odds ratio [OR] for fluoroquinolones, 3.2; 95% confidence interval [CI], 1.3 to 7.5; (P < 0.001; OR for macrolides, 5.2; 95% CI, 1.1 to 24.0; P = 0.04)). In contrast, clindamycin use was less frequent among the BI cases than among the controls (OR, 0.1; 95% CI, 0.03 to 0.4; P = 0.001). High-level resistance to moxifloxacin and azithromycin was more frequent among BI strains (moxifloxacin, 49/102 [48%] BI versus 0/40 non-BI, P = 0.0001; azithromycin, 100/102 [98%] BI versus 22/40 [55%] non-BI, P = 0.0001). High-level resistance to clindamycin was more frequent among non-BI strains (22/40 [55%] non-BI versus 7/102 [7%] BI, P = 0.0001). Fluoroquinolone use, macrolide use, and C. difficile resistance to these antibiotic classes were associated with infection by the epidemic BI strain of C. difficile in a U.S. hospital during a time when CDI rates were increasing nationally due to the highly fluoroquinolone-resistant BI/NAP1/027 strain. JF - Antimicrobial Agents & Chemotherapy AU - Wieczorkiewicz, Jeffrey T AU - Lopansri, Bert K AU - Cheknis, Adam AU - Osmolski, James R AU - Hecht, David W AU - Gerding, Dale N AU - Johnson, Stuart AD - << + $0, stuart.johnson2@va.gov. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 418 EP - 423 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 60 IS - 1 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clindamycin KW - Epidemics KW - Fluoroquinolones KW - Chemotherapy KW - Antibiotics KW - Infection KW - Toxins KW - Antimicrobial agents KW - Health risks KW - Typing KW - Multivariate analysis KW - Moxifloxacin KW - Azithromycin KW - Clostridium difficile KW - Endonuclease KW - Feces KW - Immunoassays KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials KW - H 13000:Medical Safety KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1758247329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Fluoroquinolone+and+Macrolide+Exposure+Predict+Clostridium+difficile+Infection+with+the+Highly+Fluoroquinolone-+and+Macrolide-Resistant+Epidemic+C.+difficile+Strain+BI%2FNAP1%2F027&rft.au=Wieczorkiewicz%2C+Jeffrey+T%3BLopansri%2C+Bert+K%3BCheknis%2C+Adam%3BOsmolski%2C+James+R%3BHecht%2C+David+W%3BGerding%2C+Dale+N%3BJohnson%2C+Stuart&rft.aulast=Wieczorkiewicz&rft.aufirst=Jeffrey&rft.date=2016-01-01&rft.volume=60&rft.issue=1&rft.spage=418&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01820-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Number of references - 23 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Clindamycin; Epidemics; Fluoroquinolones; Antibiotics; Infection; Toxins; Typing; Moxifloxacin; Multivariate analysis; Azithromycin; Feces; Endonuclease; Immunoassays; Hospitals; Health risks; Chemotherapy; Antimicrobial agents; Clostridium difficile DO - http://dx.doi.org/10.1128/AAC.01820-15 ER - TY - JOUR T1 - Susceptibility of Clostridium difficile isolates from a Phase 2 clinical trial of cadazolid and vancomycin in C. difficile infection. AN - 1750425194; 26433782 AB - The aim of this study was to evaluate the susceptibilities of Clostridium difficile isolates to cadazolid, a novel antibiotic for the treatment of C. difficile infection. Ribotyping and susceptibilities were determined for C. difficile isolates from a multicentre, double-blind, Phase 2 study of oral cadazolid in patients with C. difficile infection (NCT01222702, ClinicalTrials.gov; EudraCT 2010-020941-29, European Clinical Trials Database). Patients were randomized to receive 250, 500 or 1000 mg of cadazolid twice daily or 125 mg of vancomycin four times daily, for 10 days. MICs of cadazolid, vancomycin, fidaxomicin, linezolid and moxifloxacin were determined at baseline for all patients and post-baseline for patients with clinical failure or recurrence, using the agar dilution method. Seventy-eight of 84 patients had an evaluable toxigenic C. difficile isolate at baseline. The most frequent PCR ribotype was 027 (15.4%). Cadazolid MICs for baseline isolates (including epidemic strain 027) ranged from 0.06 to 0.25 mg/L. Baseline cadazolid MICs were similar to those of fidaxomicin and lower than those of vancomycin, linezolid and moxifloxacin. For each clinical outcome group (clinical cure, clinical failure, sustained clinical response and clinical failure or recurrence), the baseline cadazolid MIC range was 0.06-0.25 mg/L. Mean (min-max) cadazolid faecal concentration (μg/g) on day 5 was 884 (101-2710), 1706 (204-4230) and 3226 (1481-12 600) for the doses 250, 500 and 1000 mg, respectively. For all cadazolid doses, the faecal concentration was in excess of several thousand-fold the MIC90 for C. difficile. The MIC of cadazolid for all C. difficile isolates, including epidemic strains, was low and in the same narrow range regardless of treatment outcome. © The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. JF - The Journal of antimicrobial chemotherapy AU - Gerding, D N AU - Hecht, D W AU - Louie, T AU - Nord, C E AU - Talbot, G H AU - Cornely, O A AU - Buitrago, M AU - Best, E AU - Sambol, S AU - Osmolski, J R AU - Kracker, H AU - Locher, H H AU - Charef, P AU - Wilcox, M AD - Loyola University, Maywood, IL, USA Edward Hines Jr VA Hospital, Hines, IL, USA dale.gerding2@va.gov. ; Loyola University, Maywood, IL, USA Edward Hines Jr VA Hospital, Hines, IL, USA. ; University of Calgary, Calgary, Alberta, Canada. ; Karolinska Institute, Stockholm, Sweden. ; Talbot Advisors, Anna Maria, FL, USA. ; Department of Internal Medicine, University Hospital of Cologne, Cologne, Germany Clinical Trials Centre Cologne, University of Cologne, Cologne, Germany Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. ; Idaho Falls Infectious Diseases, Idaho Falls, ID, USA. ; Leeds General Infirmary, Leeds, UK. ; Actelion Pharmaceuticals Ltd, Allschwil, Switzerland. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 213 EP - 219 VL - 71 IS - 1 KW - Anti-Bacterial Agents KW - 0 KW - Oxazolidinones KW - cadazolid KW - 2OEA2UN10Y KW - Vancomycin KW - 6Q205EH1VU KW - Index Medicus KW - Young Adult KW - Ribotyping KW - Double-Blind Method KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Microbial Sensitivity Tests KW - Male KW - Female KW - Clostridium Infections -- drug therapy KW - Vancomycin -- pharmacology KW - Vancomycin -- administration & dosage KW - Clostridium difficile -- isolation & purification KW - Oxazolidinones -- administration & dosage KW - Anti-Bacterial Agents -- pharmacology KW - Clostridium difficile -- classification KW - Anti-Bacterial Agents -- administration & dosage KW - Oxazolidinones -- pharmacology KW - Clostridium difficile -- genetics KW - Clostridium Infections -- microbiology KW - Clostridium difficile -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1750425194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+antimicrobial+chemotherapy&rft.atitle=Susceptibility+of+Clostridium+difficile+isolates+from+a+Phase+2+clinical+trial+of+cadazolid+and+vancomycin+in+C.+difficile+infection.&rft.au=Gerding%2C+D+N%3BHecht%2C+D+W%3BLouie%2C+T%3BNord%2C+C+E%3BTalbot%2C+G+H%3BCornely%2C+O+A%3BBuitrago%2C+M%3BBest%2C+E%3BSambol%2C+S%3BOsmolski%2C+J+R%3BKracker%2C+H%3BLocher%2C+H+H%3BCharef%2C+P%3BWilcox%2C+M&rft.aulast=Gerding&rft.aufirst=D&rft.date=2016-01-01&rft.volume=71&rft.issue=1&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+antimicrobial+chemotherapy&rft.issn=1460-2091&rft_id=info:doi/10.1093%2Fjac%2Fdkv300 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-05 N1 - Date created - 2015-12-17 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT01222702; ClinicalTrials.gov; 2010-020941-29; EudraCT N1 - SuppNotes - Cited By: Clin Infect Dis. 2009 Mar 1;48(5):568-76 [19191641] Nat Rev Microbiol. 2009 Jul;7(7):526-36 [19528959] Expert Rev Anti Infect Ther. 2010 May;8(5):555-64 [20455684] Nat Rev Gastroenterol Hepatol. 2011 Jan;8(1):17-26 [21119612] N Engl J Med. 2011 Feb 3;364(5):422-31 [21288078] Gut. 1986 Oct;27(10):1169-72 [3781329] Ann Intern Med. 1992 Aug 15;117(4):297-302 [1322075] J Clin Microbiol. 1993 Jul;31(7):1870-5 [8394378] J Clin Microbiol. 1999 Feb;37(2):461-3 [9889244] J Med Microbiol. 2005 Feb;54(Pt 2):101-11 [15673502] N Engl J Med. 2005 Dec 8;353(23):2433-41 [16322603] South Med J. 2006 May;99(5):518-20 [16711316] Clin Infect Dis. 2007 Jan 15;44(2):238-44 [17173224] Antimicrob Agents Chemother. 2007 Aug;51(8):2716-9 [17517836] Clin Infect Dis. 2008 Nov 1;47(9):1162-70 [18808358] J Med Microbiol. 2008 Nov;57(Pt 11):1377-82 [18927415] Euro Surveill. 2008 Dec 4;13(49). pii: 19057 [19081002] Lancet Infect Dis. 2012 Apr;12(4):281-9 [22321770] Clin Infect Dis. 2012 Aug;55 Suppl 2:S65-70 [22752867] J Infect. 2013 Feb;66(2):115-28 [23103666] Anaerobe. 2013 Apr;20:32-5 [23454525] N Z Med J. 2013 Aug 16;126(1380):9-14 [24126745] Clin Microbiol Infect. 2014 Mar;20 Suppl 2:1-26 [24118601] Antimicrob Agents Chemother. 2014;58(2):892-900 [24277020] Antimicrob Agents Chemother. 2014;58(2):901-8 [24277035] Gut Liver. 2014 Jan;8(1):1-6 [24516694] J Antimicrob Chemother. 2014 Mar;69(3):706-14 [24106141] J Antimicrob Chemother. 2014 Mar;69(3):697-705 [24128668] Antimicrob Agents Chemother. 2015 Oct;59(10):6266-73 [26248357] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/jac/dkv300 ER - TY - JOUR T1 - A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects. AN - 1718905304; 26427409 AB - Mouse models provide important resources for many areas of vision research, pertaining to retinal development, retinal function and retinal disease. The Translational Vision Research Models (TVRM) program uses chemical mutagenesis to generate new mouse models for vision research. In this chapter, we report the identification of mouse models for Grm1, Grk1 and Lrit3. Each of these is characterized by a primary defect in the electroretinogram. All are available without restriction to the research community. JF - Advances in experimental medicine and biology AU - Charette, Jeremy R AU - Samuels, Ivy S AU - Yu, Minzhong AU - Stone, Lisa AU - Hicks, Wanda AU - Shi, Lan Ying AU - Krebs, Mark P AU - Naggert, Jürgen K AU - Nishina, Patsy M AU - Peachey, Neal S AD - The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Jeremy.Charette@jax.org. ; Louis Stokes Cleveland VA Medical Center, 44106, Cleveland, OH, USA. Ivy.Samuels@va.gov. ; Cole Eye Institute, Cleveland Clinic, 44195, Cleveland, OH, USA. YUM@ccf.org. ; The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Lisa.Stone@jax.org. ; The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Wanda.jordan@jax.org. ; The Jackson Laboratory, 04609, Bar Harbor, ME, USA. lanying_shi1234@163.com. ; The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Mark.Krebs@jax.org. ; The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Juergen.Naggert@jax.org. ; The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Nishina@jax.org. ; Louis Stokes Cleveland VA Medical Center, 44106, Cleveland, OH, USA. peachen@ccf.org. Y1 - 2016 PY - 2016 DA - 2016 SP - 177 EP - 183 VL - 854 SN - 0065-2598, 0065-2598 KW - Lrit3 protein, mouse KW - 0 KW - Membrane Proteins KW - Receptors, Metabotropic Glutamate KW - metabotropic glutamate receptor type 1 KW - G-Protein-Coupled Receptor Kinase 1 KW - EC 2.7.11.14 KW - Grk1 protein, mouse KW - Index Medicus KW - Retina KW - Mice KW - Electroretinogram KW - Photoreceptor KW - Mutagenesis KW - Animals KW - G-Protein-Coupled Receptor Kinase 1 -- genetics KW - Genetic Testing -- methods KW - Receptors, Metabotropic Glutamate -- genetics KW - Humans KW - Eye Diseases -- physiopathology KW - Vision, Ocular -- genetics KW - Disease Models, Animal KW - Translational Medical Research -- methods KW - Membrane Proteins -- genetics KW - Eye Diseases -- genetics KW - Mice, Inbred DBA KW - Alleles KW - Mice, Inbred C57BL KW - Eye Diseases -- diagnosis KW - Vision, Ocular -- physiology KW - Male KW - Electroretinography KW - Retina -- metabolism KW - Retinal Diseases -- diagnosis KW - Genetic Predisposition to Disease -- genetics KW - Retina -- physiopathology KW - Retina -- pathology KW - Retinal Diseases -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718905304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=A+Chemical+Mutagenesis+Screen+Identifies+Mouse+Models+with+ERG+Defects.&rft.au=Charette%2C+Jeremy+R%3BSamuels%2C+Ivy+S%3BYu%2C+Minzhong%3BStone%2C+Lisa%3BHicks%2C+Wanda%3BShi%2C+Lan+Ying%3BKrebs%2C+Mark+P%3BNaggert%2C+J%C3%BCrgen+K%3BNishina%2C+Patsy+M%3BPeachey%2C+Neal+S&rft.aulast=Charette&rft.aufirst=Jeremy&rft.date=2016-01-01&rft.volume=854&rft.issue=&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/10.1007%2F978-3-319-17121-0_24 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-18 N1 - Date created - 2015-10-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/978-3-319-17121-0_24 ER - TY - JOUR T1 - Comparative Effectiveness of Single versus Combination Antibiotic Prophylaxis for Infections after Transrectal Prostate Biopsy AN - 1832245252; PQ0002380877 AB - An increase in fluoroquinolone resistance and transrectal ultrasound-guided prostate (TRUS) biopsy infections has prompted the need for alternative effective antibiotic prophylaxis. We aimed to compare ciprofloxacin and other single-agent therapies to combination therapy for efficacy and adverse effects. Men who underwent a TRUS biopsy within the VA Boston health care system with documented receipt of prophylactic antibiotics periprocedure were eligible for inclusion. Postprocedure infections within 30 days were ascertained by chart review from electronic records, including any inpatient, outpatient, or urgent-care visits. Among 455 evaluable men over a 3-year period, there were 25 infections (5.49%), with sepsis occurring in 2.4%, urinary tract infections (UTI) in 1.54%, and bacteremia in 0.44% of patients. Escherichia coli was the most common urine (89%) and blood (92%) pathogen, with fluoroquinolone resistance rates of 88% and 91%, respectively. Ciprofloxacin alone was associated with significantly more infections than ciprofloxacin plus an additional agent (P = 0.014). Intramuscular gentamicin alone was also significantly associated with a higher infection rate obtained with all other regimens (P = 0.004). Any single-agent regimen, including ciprofloxacin, ceftriaxone, or gentamicin, was associated with significantly higher infection rates than any combination regimen (odds ratio [OR], 4; 95% confidence interval [CI], 1.47, 10.85; P = 0.004). Diabetes, immunosuppressive condition or medication, hospitalization within the previous year, and UTI within the previous 6 months were not associated with infection risk. Clostridium difficile infections were similar. These findings suggest that ciprofloxacin, ceftriaxone, and gentamicin alone are inferior to a combination regimen. Institutions with high failure rates of prophylaxis for TRUS biopsies should consider combination regimens derived from their local data. JF - Antimicrobial Agents & Chemotherapy AU - Marino, Kaylee AU - Parlee, Anne AU - Orlando, Ralph AU - Lerner, Lori AU - Strymish, Judith AU - Gupta, Kalpana AD - << + $0, kalpana.gupta@va.gov. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 7273 EP - 7275 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 12 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Data processing KW - Fluoroquinolones KW - Bacteremia KW - Antibiotics KW - Biopsy KW - Urinary tract KW - Ceftriaxone KW - Pathogens KW - Infection KW - Diabetes mellitus KW - Gentamicin KW - Ciprofloxacin KW - Blood KW - Sepsis KW - Urine KW - Escherichia coli KW - Prophylaxis KW - Clostridium difficile KW - Prostate KW - Side effects KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832245252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Comparative+Effectiveness+of+Single+versus+Combination+Antibiotic+Prophylaxis+for+Infections+after+Transrectal+Prostate+Biopsy&rft.au=Marino%2C+Kaylee%3BParlee%2C+Anne%3BOrlando%2C+Ralph%3BLerner%2C+Lori%3BStrymish%2C+Judith%3BGupta%2C+Kalpana&rft.aulast=Marino&rft.aufirst=Kaylee&rft.date=2015-12-01&rft.volume=59&rft.issue=12&rft.spage=7273&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01457-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 9 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Data processing; Fluoroquinolones; Bacteremia; Biopsy; Antibiotics; Pathogens; Ceftriaxone; Urinary tract; Infection; Gentamicin; Diabetes mellitus; Blood; Ciprofloxacin; Sepsis; Urine; Prophylaxis; Prostate; Side effects; Escherichia coli; Clostridium difficile DO - http://dx.doi.org/10.1128/AAC.01457-15 ER - TY - JOUR T1 - A multi-targeted approach to suppress tumor-promoting inflammation. AN - 1736411274; 25951989 AB - Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Seminars in cancer biology AU - Samadi, Abbas K AU - Bilsland, Alan AU - Georgakilas, Alexandros G AU - Amedei, Amedeo AU - Amin, Amr AU - Bishayee, Anupam AU - Azmi, Asfar S AU - Lokeshwar, Bal L AU - Grue, Brendan AU - Panis, Carolina AU - Boosani, Chandra S AU - Poudyal, Deepak AU - Stafforini, Diana M AU - Bhakta, Dipita AU - Niccolai, Elena AU - Guha, Gunjan AU - Vasantha Rupasinghe, H P AU - Fujii, Hiromasa AU - Honoki, Kanya AU - Mehta, Kapil AU - Aquilano, Katia AU - Lowe, Leroy AU - Hofseth, Lorne J AU - Ricciardiello, Luigi AU - Ciriolo, Maria Rosa AU - Singh, Neetu AU - Whelan, Richard L AU - Chaturvedi, Rupesh AU - Ashraf, S Salman AU - Shantha Kumara, H M C AU - Nowsheen, Somaira AU - Mohammed, Sulma I AU - Keith, W Nicol AU - Helferich, William G AU - Yang, Xujuan AD - Sanus Biosciences, San Diego, CA, United States. ; Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, UK. ; Physics Department, School of Applied Mathematics and Physical Sciences, National Technical University of Athens, Athens, Greece. ; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy. ; Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates; Faculty of Science, Cairo University, Cairo, Egypt. ; Department of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, Miami, FL, United States. ; Department of Pathology, Wayne State Univeristy, Karmanos Cancer Center, Detroit, MI, USA. ; Department of Urology, University of Miami, Miller School of Medicine, Miami, FL, United States; Miami Veterans Administration Medical Center, Miami, FL, United States. ; Department of Environmental Science, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada. ; Laboratory of Inflammatory Mediators, State University of West Paraná, UNIOESTE, Paraná, Brazil. ; Department of BioMedical Sciences, School of Medicine, Creighton University, Omaha, NE, United States. ; Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC, United States. ; Huntsman Cancer Institute and Department of Internal Medicine, University of Utah, Salt Lake City, UT, United States. ; School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamil Nadu, India. ; University of Florence, Florence, Italy. ; Department of Environmental Sciences, Faculty of Agriculture and Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. ; Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara, Japan. ; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, United States. ; Department of Biology, University of Rome "Tor Vergata", Rome, Italy. ; Getting to Know Cancer, Truro, Nova Scotia, Canada. Electronic address: leroy.lowe@gettingtoknowcancer.org. ; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. ; Advanced Molecular Science Research Centre (Centre for Advanced Research), King George's Medical University, Lucknow, Uttar Pradesh, India. ; Department of Surgery, St. Luke's Roosevelt Hospital, New York, NY, United States. ; School of Biotechnology, Jawaharlal Nehru University, New Delhi, India. ; Department of Chemistry, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates. ; Medical Scientist Training Program, Mayo Graduate School, Mayo Medical School, Mayo Clinic, Rochester, MN, United States. ; Department of Comparative Pathobiology, Purdue University Center for Cancer Research, West Lafayette, IN, United States. ; University of Illinois at Urbana Champaign, Champaign, IL, United States. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - S151 EP - S184 VL - 35 Suppl KW - Antineoplastic Agents KW - 0 KW - Neoplasm Proteins KW - Index Medicus KW - Tumor KW - Phytochemicals KW - Hallmarks KW - Cancer KW - Inflammation KW - Genetic Heterogeneity -- drug effects KW - Humans KW - Signal Transduction -- drug effects KW - Molecular Targeted Therapy KW - Cell Transformation, Neoplastic -- drug effects KW - Neoplasms -- drug therapy KW - Neoplasms -- pathology KW - Neoplasm Proteins -- antagonists & inhibitors KW - Inflammation -- genetics KW - Inflammation -- drug therapy KW - Antineoplastic Agents -- therapeutic use KW - Neoplasms -- genetics KW - Inflammation -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1736411274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+cancer+biology&rft.atitle=A+multi-targeted+approach+to+suppress+tumor-promoting+inflammation.&rft.au=Samadi%2C+Abbas+K%3BBilsland%2C+Alan%3BGeorgakilas%2C+Alexandros+G%3BAmedei%2C+Amedeo%3BAmin%2C+Amr%3BBishayee%2C+Anupam%3BAzmi%2C+Asfar+S%3BLokeshwar%2C+Bal+L%3BGrue%2C+Brendan%3BPanis%2C+Carolina%3BBoosani%2C+Chandra+S%3BPoudyal%2C+Deepak%3BStafforini%2C+Diana+M%3BBhakta%2C+Dipita%3BNiccolai%2C+Elena%3BGuha%2C+Gunjan%3BVasantha+Rupasinghe%2C+H+P%3BFujii%2C+Hiromasa%3BHonoki%2C+Kanya%3BMehta%2C+Kapil%3BAquilano%2C+Katia%3BLowe%2C+Leroy%3BHofseth%2C+Lorne+J%3BRicciardiello%2C+Luigi%3BCiriolo%2C+Maria+Rosa%3BSingh%2C+Neetu%3BWhelan%2C+Richard+L%3BChaturvedi%2C+Rupesh%3BAshraf%2C+S+Salman%3BShantha+Kumara%2C+H+M+C%3BNowsheen%2C+Somaira%3BMohammed%2C+Sulma+I%3BKeith%2C+W+Nicol%3BHelferich%2C+William+G%3BYang%2C+Xujuan&rft.aulast=Samadi&rft.aufirst=Abbas&rft.date=2015-12-01&rft.volume=35+Suppl&rft.issue=&rft.spage=S151&rft.isbn=&rft.btitle=&rft.title=Seminars+in+cancer+biology&rft.issn=1096-3650&rft_id=info:doi/10.1016%2Fj.semcancer.2015.03.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-07 N1 - Date created - 2015-11-23 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5419-24 [17369354] Curr Opin Genet Dev. 2007 Apr;17(2):145-50 [17317150] In Vivo. 2007 Mar-Apr;21(2):365-70 [17436589] Science. 2007 Apr 27;316(5824):604-8 [17463289] J Biol Chem. 2007 May 11;282(19):14328-36 [17363372] Cancer Chemother Pharmacol. 2007 Jul;60(2):171-7 [17051370] Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):962-8 [17507623] Cancer Res. 2007 May 15;67(10):4725-31 [17510400] J Nutr Biochem. 2007 Jul;18(7):449-56 [17049831] Cancer Res. 2007 Jun 15;67(12):5940-8 [17575164] Braz J Med Biol Res. 2007 Aug;40(8):1071-8 [17665043] Cancer Res. 2007 Aug 1;67(15):7518-24 [17671223] Blood. 2007 Aug 15;110(4):1168-77 [17426256] Blood. 2007 Aug 15;110(4):1330-3 [17496199] Gastroenterology. 2007 Aug;133(2):647-58 [17681183] Chest. 2007 Aug;132(2):581-8 [17550932] Anticancer Drugs. 2007 Jul;18(6):649-57 [17762393] Cell. 2007 Sep 7;130(5):918-31 [17803913] Hum Reprod. 2007 Oct;22(10):2623-31 [17725991] Int J Cancer. 2007 Dec 1;121(11):2373-80 [17893866] J Immunol. 2007 Oct 15;179(8):5082-9 [17911593] Inflamm Bowel Dis. 2007 Nov;13(11):1323-32 [17636564] J Agric Food Chem. 1999 Mar;47(3):1083-91 [10552420] Oncogene. 1999 Oct 28;18(44):6013-20 [10557090] J Exp Med. 1999 Nov 15;190(10):1417-26 [10562317] Breast Cancer Res Treat. 1999 Jul;56(2):145-51 [10573107] Clin Cancer Res. 1999 Nov;5(11):3711-21 [10589791] J Exp Clin Cancer Res. 1999 Sep;18(3):433-7 [10606191] Lab Invest. 1999 Dec;79(12):1703-12 [10616218] J Ethnopharmacol. 1999 Oct;67(1):1-6 [10616954] J Clin Immunol. 1999 Nov;19(6):350-64 [10634209] Cancer. 2000 Feb 1;88(3):577-83 [10649250] Mol Cell Biol. 2000 Feb;20(4):1382-93 [10648623] Cancer Lett. 1999 Nov 15;146(2):173-80 [10656623] Ann Clin Lab Sci. 2000 Jan;30(1):3-21 [10678579] Hum Gene Ther. 2000 Jan 20;11(2):247-61 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AN - 1736411130; 26590477 AB - Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested, many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment. Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to be relatively inexpensive, it should help us address stages and types of cancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for future research is offered. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved. JF - Seminars in cancer biology AU - Block, Keith I AU - Gyllenhaal, Charlotte AU - Lowe, Leroy AU - Amedei, Amedeo AU - Amin, A R M Ruhul AU - Amin, Amr AU - Aquilano, Katia AU - Arbiser, Jack AU - Arreola, Alexandra AU - Arzumanyan, Alla AU - Ashraf, S Salman AU - Azmi, Asfar S AU - Benencia, Fabian AU - Bhakta, Dipita AU - Bilsland, Alan AU - Bishayee, Anupam AU - Blain, Stacy W AU - Block, Penny B AU - Boosani, Chandra S AU - Carey, Thomas E AU - Carnero, Amancio AU - Carotenuto, Marianeve AU - Casey, Stephanie C AU - Chakrabarti, Mrinmay AU - Chaturvedi, Rupesh AU - Chen, Georgia Zhuo AU - Chen, Helen AU - Chen, Sophie AU - Chen, Yi Charlie AU - Choi, Beom K AU - Ciriolo, Maria Rosa AU - Coley, Helen M AU - Collins, Andrew R AU - Connell, Marisa AU - Crawford, Sarah AU - Curran, Colleen S AU - Dabrosin, Charlotta AU - Damia, Giovanna AU - Dasgupta, Santanu AU - DeBerardinis, Ralph J AU - Decker, William K AU - Dhawan, Punita AU - Diehl, Anna Mae E AU - Dong, Jin-Tang AU - Dou, Q Ping AU - Drew, Janice E AU - Elkord, Eyad AU - El-Rayes, Bassel AU - Feitelson, Mark A AU - Felsher, Dean W AU - Ferguson, Lynnette R AU - Fimognari, Carmela AU - Firestone, Gary L AU - Frezza, Christian AU - Fujii, Hiromasa AU - Fuster, Mark M AU - Generali, Daniele AU - Georgakilas, Alexandros G AU - Gieseler, Frank AU - Gilbertson, Michael AU - Green, Michelle F AU - Grue, Brendan AU - Guha, Gunjan AU - Halicka, Dorota AU - Helferich, William G AU - Heneberg, Petr AU - Hentosh, Patricia AU - Hirschey, Matthew D AU - Hofseth, Lorne J AU - Holcombe, Randall F AU - Honoki, Kanya AU - Hsu, Hsue-Yin AU - Huang, Gloria S AU - Jensen, Lasse D AU - Jiang, Wen G AU - Jones, Lee W AU - Karpowicz, Phillip A AU - Keith, W Nicol AU - Kerkar, Sid P AU - Khan, Gazala N AU - Khatami, Mahin AU - Ko, Young H AU - Kucuk, Omer AU - Kulathinal, Rob J AU - Kumar, Nagi B AU - Kwon, Byoung S AU - Le, Anne AU - Lea, Michael A AU - Lee, Ho-Young AU - Lichtor, Terry AU - Lin, Liang-Tzung AU - Locasale, Jason W AU - Lokeshwar, Bal L AU - Longo, Valter D AU - Lyssiotis, Costas A AU - MacKenzie, Karen L AU - Malhotra, Meenakshi AU - Marino, Maria AU - Martinez-Chantar, Maria L AU - Matheu, Ander AU - Maxwell, Christopher AU - McDonnell, Eoin AU - Meeker, Alan K AU - Mehrmohamadi, Mahya AU - Mehta, Kapil AU - Michelotti, Gregory A AU - Mohammad, Ramzi M AU - Mohammed, Sulma I AU - Morre, D James AU - Muralidhar, Vinayak AU - Muqbil, Irfana AU - Murphy, Michael P AU - Nagaraju, Ganji Purnachandra AU - Nahta, Rita AU - Niccolai, Elena AU - Nowsheen, Somaira AU - Panis, Carolina AU - Pantano, Francesco AU - Parslow, Virginia R AU - Pawelec, Graham AU - Pedersen, Peter L AU - Poore, Brad AU - Poudyal, Deepak AU - Prakash, Satya AU - Prince, Mark AU - Raffaghello, Lizzia AU - Rathmell, Jeffrey C AU - Rathmell, W Kimryn AU - Ray, Swapan K AU - Reichrath, Jörg AU - Rezazadeh, Sarallah AU - Ribatti, Domenico AU - Ricciardiello, Luigi AU - Robey, R Brooks AU - Rodier, Francis AU - Rupasinghe, H P Vasantha AU - Russo, Gian Luigi AU - Ryan, Elizabeth P AU - Samadi, Abbas K AU - Sanchez-Garcia, Isidro AU - Sanders, Andrew J AU - Santini, Daniele AU - Sarkar, Malancha AU - Sasada, Tetsuro AU - Saxena, Neeraj K AU - Shackelford, Rodney E AU - Shantha Kumara, H M C AU - Sharma, Dipali AU - Shin, Dong M AU - Sidransky, David AU - Siegelin, Markus David AU - Signori, Emanuela AU - Singh, Neetu AU - Sivanand, Sharanya AU - Sliva, Daniel AU - Smythe, Carl AU - Spagnuolo, Carmela AU - Stafforini, Diana M AU - Stagg, John AU - Subbarayan, Pochi R AU - Sundin, Tabetha AU - Talib, Wamidh H AU - Thompson, Sarah K AU - Tran, Phuoc T AU - Ungefroren, Hendrik AU - Vander Heiden, Matthew G AU - Venkateswaran, Vasundara AU - Vinay, Dass S AU - Vlachostergios, Panagiotis J AU - Wang, Zongwei AU - Wellen, Kathryn E AU - Whelan, Richard L AU - Yang, Eddy S AU - Yang, Huanjie AU - Yang, Xujuan AU - Yaswen, Paul AU - Yedjou, Clement AU - Yin, Xin AU - Zhu, Jiyue AU - Zollo, Massimo AD - Block Center for Integrative Cancer Treatment, Skokie, IL, United States. Electronic address: drblock@blockmedical.com. ; Block Center for Integrative Cancer Treatment, Skokie, IL, United States. ; Getting to Know Cancer, Truro, Nova Scotia, Canada; Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster, United Kingdom. Electronic address: Leroy.lowe@gettingtoknowcancer.org. ; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy. ; Winship Cancer Institute of Emory University, Atlanta, GA, United States. ; Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates. ; Department of Biology, University of Rome "Tor Vergata", Rome, Italy. ; Winship Cancer Institute of Emory University, Atlanta, GA, United States; Atlanta Veterans Administration Medical Center, Atlanta, GA, United States; Department of Dermatology, Emory University School of Medicine, Emory University, Atlanta, GA, United States. ; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States. ; Department of Biology, Temple University, Philadelphia, PA, United States. ; Department of Chemistry, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates. ; Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, United States. ; Department of Biomedical Sciences, Ohio University, Athens, OH, United States. ; School of Chemical and Bio Technology, SASTRA University, Thanjavur, Tamil Nadu, India. ; University of Glasgow, Glasgow, United Kingdom. ; Department of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, Miami, FL, United States. ; Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn, NY, United States. ; Department of BioMedical Sciences, School of Medicine, Creighton University, Omaha, NE, United States. ; Head and Neck Cancer Biology Laboratory, University of Michigan, Ann Arbor, MI, United States. ; Instituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Cientificas, Seville, Spain. ; Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy. ; Stanford University, Division of Oncology, Department of Medicine and Pathology, Stanford, CA, United States. ; Department of Pathology, Microbiology, and Immunology, University of South Carolina, School of Medicine, Columbia, SC, United States. ; School of Biotechnology, Jawaharlal Nehru University, New Delhi, India. ; Department of Pediatrics, University of British Columbia, Michael Cuccione Childhood Cancer Research Program, Child and Family Research Institute, Vancouver, British Columbia, Canada. ; Ovarian and Prostate Cancer Research Laboratory, Guildford, Surrey, United Kingdom. ; Department of Biology, Alderson Broaddus University, Philippi, WV, United States. ; Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Goyang, Gyeonggi, Republic of Korea. ; Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, United Kingdom. ; Department of Nutrition, Faculty of Medicine, University of Oslo, Oslo, Norway. ; Cancer Biology Research Laboratory, Southern Connecticut State University, New Haven, CT, United States. ; School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States. ; Department of Oncology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. ; Department of Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. ; Department of Cellular and Molecular Biology, the University of Texas Health Science Center at Tyler, Tyler, TX, United States. ; Children's Medical Center Research Institute, University of Texas - Southwestern Medical Center, Dallas, TX, United States. ; Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, United States. ; Department of Surgery and Cancer Biology, Division of Surgical Oncology, Vanderbilt University School of Medicine, Nashville, TN, United States. ; Department of Medicine, Duke University Medical Center, Durham, NC, United States. ; Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, Scotland, United Kingdom. ; College of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. ; Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, United States. ; Discipline of Nutrition and Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand. ; Dipartimento di Scienze per la Qualità della Vita Alma Mater Studiorum-Università di Bologna, Rimini, Italy. ; Department of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, United States. ; Medical Research Council Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, United Kingdom. ; Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara, Japan. ; Medicine and Research Services, Veterans Affairs San Diego Healthcare System & University of California, San Diego, CA, United States. ; Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Molecular Therapy and Pharmacogenomics Unit, Azienda Ospedaliera Istituti Ospitalieri di Cremona, Cremona, Italy. ; Physics Department, School of Applied Mathematics and Physical Sciences, National Technical University of Athens, Athens, Greece. ; First Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. ; Getting to Know Cancer, Guelph, Canada. ; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, United States. ; Departments of Environmental Science, Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada. ; Department of Pathology, New York Medical College, Valhalla, NY, United States. ; University of Illinois at Urbana Champaign, Champaign, IL, United States. ; Charles University in Prague, Third Faculty of Medicine, Prague, Czech Republic. ; School of Medical Laboratory and Radiation Sciences, Old Dominion University, Norfolk, VA, United States. ; Department of Medicine, Duke University Medical Center, Durham, NC, United States; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, United States. ; College of Pharmacy, University of South Carolina, Columbia, SC, United States. ; Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, United States. ; Department of Life Sciences, Tzu-Chi University, Hualien, Taiwan. ; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States. ; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. ; Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom. ; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, United States. ; University of Windsor, Windsor, Ontario, Canada. ; Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States. ; Henry Ford Hospital, Detroit, MI, United States. ; Inflammation and Cancer Research, National Cancer Institute (Retired), National Institutes of Health, Bethesda, MD, United States. ; University of Maryland BioPark, Innovation Center, KoDiscovery, Baltimore, MD, United States. ; Moffitt Cancer Center, University of South Florida College of Medicine, Tampa, FL, United States. ; Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Goyang, Gyeonggi, Republic of Korea; Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, United States. ; The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States. ; New Jersey Medical School, Rutgers University, Newark, NJ, United States. ; College of Pharmacy, Seoul National University, South Korea. ; Department of Neurosurgery, Rush University Medical Center, Chicago, IL, United States. ; Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. ; Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. ; Department of Medicine, Georgia Regents University Cancer Center, Augusta, GA, United States. ; Andrus Gerontology Center, Division of Biogerontology, University of Southern California, Los Angeles, CA, United States. ; Department of Molecular and Integrative Physiology and Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, United States. ; Children's Cancer Institute Australia, Kensington, New South Wales, Australia. ; Department of Biomedical Engineering, McGill University, Montréal, Canada. ; Department of Science, University Roma Tre, Rome, Italy. ; Metabolomic Unit, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Technology Park of Bizkaia, Bizkaia, Spain. ; Biodonostia Institute, Gipuzkoa, Spain. ; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States. ; Field of Genetics, Genomics, and Development, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, United States. ; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, United States. ; Department of Comparative Pathobiology, Purdue University Center for Cancer Research, West Lafayette, IN, United States. ; Mor-NuCo, Inc, Purdue Research Park, West Lafayette, IN, United States. ; Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, United States; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States. ; MRC Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Hills Road, Cambridge, United Kingdom. ; University of Florence, Florence, Italy. ; Medical Scientist Training Program, Mayo Graduate School, Mayo Medical School, Mayo Clinic, Rochester, MN, United States. ; Laboratory of Inflammatory Mediators, State University of West Paraná, UNIOESTE, Paraná, Brazil. ; Medical Oncology Department, University Campus Bio-Medico, Rome, Italy. ; Center for Medical Research, University of Tübingen, Tübingen, Germany. ; Departments of Biological Chemistry and Oncology, Member at Large, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD, United States. ; Department of Otolaryngology-Head and Neck, Medical School, University of Michigan, Ann Arbor, MI, United States. ; Laboratory of Oncology, Istituto Giannina Gaslini, Genoa, Italy. ; Center for Clinical and Experimental Photodermatology, Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, Homburg, Germany. ; Department of Biology, University of Rochester, Rochester, NY, United States. ; Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy & National Cancer Institute Giovanni Paolo II, Bari, Italy. ; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. ; White River Junction Veterans Affairs Medical Center, White River Junction, VT, United States; Geisel School of Medicine at Dartmouth, Hanover, NH, United States. ; Centre de Rechercher du Centre Hospitalier de l'Université de Montréal and Institut du Cancer de Montréal, Montréal, Quebec, Canada; Université de Montréal, Département de Radiologie, Radio-Oncologie et Médicine Nucléaire, Montréal, Quebec, Canada. ; Department of Environmental Sciences, Faculty of Agriculture and Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. ; Institute of Food Sciences National Research Council, Avellino, Italy. ; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, United States. ; Sanus Biosciences, San Diego, CA, United States. ; Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC-Universidad de Salamanca, Salamanca, Spain. ; Department of Biology, University of Miami, Miami, FL, United States. ; Department of Immunology, Kurume University School of Medicine, Kurume, Fukuoka, Japan. ; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States. ; Department of Pathology, Louisiana State University, Health Shreveport, Shreveport, LA, United States. ; Department of Surgery, St. Luke's Roosevelt Hospital, New York, NY, United States. ; Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, United States. ; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States. ; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, United States. ; National Research Council, Institute of Translational Pharmacology, Rome, Italy. ; Advanced Molecular Science Research Centre (Centre for Advanced Research), King George's Medical University, Lucknow, Uttar Pradesh, India. ; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. ; DSTest Laboratories, Purdue Research Park, Indianapolis, IN, United States. ; Department of Biomedical Science, Sheffield Cancer Research Centre, University of Sheffield, Sheffield, United Kingdom. ; Huntsman Cancer Institute and Department of Internal Medicine, University of Utah, Salt Lake City, UT, United States. ; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Faculté de Pharmacie et Institut du Cancer de Montréal, Montréal, Quebec, Canada. ; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States. ; Department of Molecular Diagnostics, Sentara Healthcare, Norfolk, VA, United States. ; Department of Clinical Pharmacy and Therapeutics, Applied Science University, Amman, Jordan. ; Department of Surgery, Royal Adelaide Hospital, Adelaide, Australia. ; Departments of Radiation Oncology & Molecular Radiation Sciences, Oncology and Urology, Johns Hopkins School of Medicine, Baltimore, MD, United States. ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States. ; Department of Surgery, University of Toronto, Division of Urology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. ; Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, United States. ; Department of Internal Medicine, New York University Lutheran Medical Center, Brooklyn, New York, NY, United States. ; Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. ; Department of Radiation Oncology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, United States. ; The School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China. ; Life Sciences Division, Lawrence Berkeley National Lab, Berkeley, CA, United States. ; Department of Biology, Jackson State University, Jackson, MS, United States. ; Washington State University College of Pharmacy, Spokane, WA, United States. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - S276 EP - S304 VL - 35 Suppl KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Index Medicus KW - Integrative medicine KW - Multi-targeted KW - Targeted therapy KW - Phytochemicals KW - Cancer hallmarks KW - Tumor Microenvironment -- genetics KW - Humans KW - Drug Resistance, Neoplasm -- genetics KW - Antineoplastic Agents, Phytogenic -- therapeutic use KW - Signal Transduction KW - Neoplasms -- pathology KW - Precision Medicine KW - Molecular Targeted Therapy KW - Neoplasms -- prevention & control KW - Neoplasms -- therapy KW - Neoplasms -- genetics KW - Genetic Heterogeneity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1736411130?accountid=14244 L2 - 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Due to the difficulty in distinguishing viridans group streptococci (VGS) by phenotype, analysis of 16S rRNA sequences is necessary for the accurate identification of most species. Through a laboratory policy of analyzing all clinically significant isolates from the VGS group by16S rRNA gene sequencing, we identified 14 S. tigurinus isolates from 11 patients. The Vitek 2 system most commonly gave an excellent rating to an incorrect identification (e.g., Streptococcus mitis), as did matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) (e.g., Streptococcus oralis). S. tigurinus strains were recovered from numerous body sites, including the blood, peritoneal fluid, bone, synovial fluid, a perianal abscess, and an arm wound. Retrospective chart review indicated that most isolates were clinically significant, with bacteremia (n = 5), soft tissue infections (n = 3) osteomyelitis (n = 2), infected joint prosthesis (n = 2), and peritonitis (n = 2) being the most common, thus expanding the spectrum of disease associated with S. tigurinus. JF - Journal of Clinical Microbiology AU - Bourassa, Lori AU - Clarridge, J E, III AD - << + $0, jill.clarridge@va.gov. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 3574 EP - 3579 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 11 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Peritonitis KW - Bacteremia KW - Abscesses KW - Infection KW - Mass spectroscopy KW - Wounds KW - Joints KW - Blood KW - rRNA KW - Synovial fluid KW - Lasers KW - Streptococcus mitis KW - Soft tissues KW - rRNA 16S KW - Streptococcus oralis KW - peritoneal fluid KW - Osteomyelitis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751214286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Clinical+Significance+and+Characterization+of+Streptococcus+tigurinus+Isolates+in+an+Adult+Population&rft.au=Bourassa%2C+Lori%3BClarridge%2C+J+E%2C+III&rft.aulast=Bourassa&rft.aufirst=Lori&rft.date=2015-11-01&rft.volume=53&rft.issue=11&rft.spage=3574&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.01551-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 21 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Peritonitis; Bacteremia; Infection; Abscesses; Mass spectroscopy; Joints; Wounds; rRNA; Blood; Synovial fluid; Lasers; rRNA 16S; Soft tissues; Osteomyelitis; peritoneal fluid; Streptococcus; Streptococcus mitis; Streptococcus oralis DO - http://dx.doi.org/10.1128/JCM.01551-15 ER - TY - JOUR T1 - Elevated glutathione is not sufficient to protect against doxorubicin-induced nuclear damage in heart in multidrug resistance-associated protein 1 (Mrp1/Abcc1) null mice. AN - 1722186201; 26354996 AB - Cardiotoxicity is a major dose-limiting adverse effect of doxorubicin (DOX), mediated in part by overproduction of reactive oxygen species and oxidative stress. Abcc1 (Mrp1) mediates the efflux of reduced and oxidized glutathione (GSH, GSSG) and is also a major transporter that effluxes the GSH conjugate of 4-hydroxy-2-nonenal (HNE; GS-HNE), a toxic product of lipid peroxidation formed during oxidative stress. To assess the role of Mrp1 in protecting the heart from DOX-induced cardiac injury, wild-type (WT) and Mrp1 null (Mrp1(-/-)) C57BL/6 littermate mice were administered DOX (15 mg/kg) or saline (7.5 ml/kg) i.v., and heart ventricles were examined at 72 hours. Morphometric analysis by electron microscopy revealed extensive injuries in cytosol, mitochondria, and nuclei of DOX-treated mice in both genotypes. Significantly more severely injured nuclei were observed in Mrp1(-/-) versus WT mice (P = 0.031). GSH and the GSH/GSSG ratio were significantly increased in treatment-naïve Mrp1(-/-) versus WT mice; GSH remained significantly higher in Mrp1(-/-) versus WT mice after saline and DOX treatment, with no changes in GSSG or GSH/GSSG. GS-HNE, measured by mass spectrometry, was lower in the hearts of treatment-naïve Mrp1(-/-) versus WT mice (P < 0.05). DOX treatment decreased GS-HNE in WT but not Mrp1(-/-) mice, so that GS-HNE was modestly but significantly higher in Mrp1(-/-) versus WT hearts after DOX. Expression of enzymes mediating GSH synthesis and antioxidant proteins did not differ between genotypes. Thus, despite elevated GSH levels in Mrp1(-/-) hearts, DOX induced significantly more injury in the nuclei of Mrp1(-/-) versus WT hearts. Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics. JF - The Journal of pharmacology and experimental therapeutics AU - Deng, Jun AU - Coy, Donna AU - Zhang, Wei AU - Sunkara, Manjula AU - Morris, Andrew J AU - Wang, Chi AU - Chaiswing, Luksana AU - St Clair, Daret AU - Vore, Mary AU - Jungsuwadee, Paiboon AD - Department of Toxicology and Cancer Biology (J.D., D.C., L.C., W.Z., D.St.C., M.V.), Division of Cardiovascular Medicine (M.S., A.J.M.), Markey Cancer Center (C.W.) University of Kentucky, Lexington, Kentucky; Department of Pathology and Laboratory Medicine, William S. Middleton Memorial Veterans Administration Hospital and University of Wisconsin Medical School, Madison Wisconsin (L.C.); and School of Pharmacy, Fairleigh Dickinson University, Florham Park, New Jersey (P.J.). ; Department of Toxicology and Cancer Biology (J.D., D.C., L.C., W.Z., D.St.C., M.V.), Division of Cardiovascular Medicine (M.S., A.J.M.), Markey Cancer Center (C.W.) University of Kentucky, Lexington, Kentucky; Department of Pathology and Laboratory Medicine, William S. Middleton Memorial Veterans Administration Hospital and University of Wisconsin Medical School, Madison Wisconsin (L.C.); and School of Pharmacy, Fairleigh Dickinson University, Florham Park, New Jersey (P.J.) maryv@email.uky.edu paiboon@fdu.edu. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 272 EP - 279 VL - 355 IS - 2 KW - Antibiotics, Antineoplastic KW - 0 KW - Multidrug Resistance-Associated Proteins KW - glutathionyl 4-hydroxy-2-nonenal conjugate KW - Doxorubicin KW - 80168379AG KW - Glutathione KW - GAN16C9B8O KW - Glutathione Disulfide KW - ULW86O013H KW - multidrug resistance-associated protein 1 KW - Y49M64GZ4Q KW - Index Medicus KW - Animals KW - Glutathione Disulfide -- metabolism KW - Oxidative Stress KW - Mice, Inbred C57BL KW - Lipid Peroxidation KW - Cardiotoxicity -- metabolism KW - Mice, Knockout KW - Glutathione -- metabolism KW - Multidrug Resistance-Associated Proteins -- genetics KW - Myocardium -- ultrastructure KW - Doxorubicin -- toxicity KW - Cell Nucleus -- drug effects KW - Myocardium -- metabolism KW - Glutathione -- analogs & derivatives KW - Antibiotics, Antineoplastic -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722186201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Elevated+glutathione+is+not+sufficient+to+protect+against+doxorubicin-induced+nuclear+damage+in+heart+in+multidrug+resistance-associated+protein+1+%28Mrp1%2FAbcc1%29+null+mice.&rft.au=Deng%2C+Jun%3BCoy%2C+Donna%3BZhang%2C+Wei%3BSunkara%2C+Manjula%3BMorris%2C+Andrew+J%3BWang%2C+Chi%3BChaiswing%2C+Luksana%3BSt+Clair%2C+Daret%3BVore%2C+Mary%3BJungsuwadee%2C+Paiboon&rft.aulast=Deng&rft.aufirst=Jun&rft.date=2015-11-01&rft.volume=355&rft.issue=2&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.115.225490 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-04 N1 - Date created - 2015-10-10 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H761-7 [18567705] Mol Cancer Ther. 2006 Nov;5(11):2851-60 [17121932] Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H829-35 [19561313] J Biol Chem. 2010 Apr 16;285(16):12416-25 [20159984] Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1282-90 [21297025] Chem Rev. 2011 Oct 12;111(10):5973-96 [21848345] Biochem Pharmacol. 2012 Apr 15;83(8):1005-12 [22138445] Pharmacogenet Genomics. 2012 Apr;22(4):273-84 [22293538] Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1387-93 [22268115] J Mol Cell Cardiol. 2012 Jun;52(6):1213-25 [22465037] Cardiovasc Res. 2013 Feb 1;97(2):282-92 [23129588] Toxicol Sci. 2013 Mar;132(1):235-49 [23152189] Antioxid Redox Signal. 2014 Feb 1;20(4):621-39 [23879289] Free Radic Biol Med. 2014 Sep;74:188-99 [24973647] Mol Med. 2014;20:390-9 [25105301] Br J Pharmacol. 2014 Dec;171(24):5845-57 [25164592] J Pharmacol Exp Ther. 2015 Nov;355(2):280-7 [26354995] Anal Biochem. 2000 Apr 10;280(1):80-6 [10805524] Biochem J. 2000 Sep 1;350 Pt 2:555-61 [10947971] Circulation. 2000 Oct 24;102(17):2105-10 [11044428] J Biol Chem. 2001 Apr 20;276(16):13231-9 [11278596] Mol Aspects Med. 2003 Aug-Oct;24(4-5):177-87 [12892995] J Biol Chem. 1986 Feb 5;261(4):1576-81 [3753704] FASEB J. 1990 Oct;4(13):3076-86 [2210154] Science. 1992 Dec 4;258(5088):1650-4 [1360704] Mutat Res. 1993 Dec;290(2):183-92 [7694109] J Clin Invest. 1996 Sep 1;98(5):1253-60 [8787689] Biochim Biophys Acta. 1997 Feb 27;1360(1):45-52 [9061039] Cancer Res. 1997 Dec 1;57(23):5238-42 [9393741] Toxicol Appl Pharmacol. 1999 Jun 1;157(2):85-93 [10366541] Toxicol Pathol. 2004 Sep-Oct;32(5):536-47 [15605432] Free Radic Biol Med. 2005 Jun 1;38(11):1526-36 [15890627] Circulation. 2005 Dec 13;112(24):3754-62 [16330681] Mol Aspects Med. 2009 Feb-Apr;30(1-2):86-98 [18812186] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1124/jpet.115.225490 ER - TY - CPAPER T1 - Overview of Veterans Health Administration (VHA) Public Health Reporting to State and Territorial Public Health Authorities (PHA) T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731769187; 6365014 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Oda, Gina AU - Akaka, Loren Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Reviews KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731769187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Overview+of+Veterans+Health+Administration+%28VHA%29+Public+Health+Reporting+to+State+and+Territorial+Public+Health+Authorities+%28PHA%29&rft.au=Oda%2C+Gina%3BAkaka%2C+Loren&rft.aulast=Oda&rft.aufirst=Gina&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Improving the health of our nation's veterans by implementing healthy food service guidelines T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731766819; 6367365 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Bosley, Ellen AU - Ulin, Brigette AU - Lowry, Amy AU - Kimmons, Joel Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Food KW - Guidelines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731766819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Improving+the+health+of+our+nation%27s+veterans+by+implementing+healthy+food+service+guidelines&rft.au=Bosley%2C+Ellen%3BUlin%2C+Brigette%3BLowry%2C+Amy%3BKimmons%2C+Joel&rft.aulast=Bosley&rft.aufirst=Ellen&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Veterans Health Administration's Public Health Reporting Toolkit; Reducing the Complexity of Public Health Reporting to State, Local and Territory Public Health Departments T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731765245; 6365015 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Akaka, Loren AU - Medina-Martinez, Gisela AU - Rivera-Colon, Alessandra AU - Wu, Melody Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Home range KW - Territory KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731765245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Veterans+Health+Administration%27s+Public+Health+Reporting+Toolkit%3B+Reducing+the+Complexity+of+Public+Health+Reporting+to+State%2C+Local+and+Territory+Public+Health+Departments&rft.au=Akaka%2C+Loren%3BMedina-Martinez%2C+Gisela%3BRivera-Colon%2C+Alessandra%3BWu%2C+Melody&rft.aulast=Akaka&rft.aufirst=Loren&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - JOUR T1 - "Respect the way I need to communicate with you": Healthcare experiences of adults on the autism spectrum AN - 1865906282 AB - Our objective was to obtain an in-depth understanding of autistic adults' experiences with healthcare and their recommendations for improving care. Our academic-community partnership used a community-based participatory research approach to conduct semi-structured, open-ended interviews with 39 autistic adults and 16 people who had experience supporting autistic adults in healthcare settings. Participants identified patient-level, autism-related factors that impact healthcare interactions, including verbal communication skills, sensory sensitivities, challenges with body awareness, slow processing speed, atypical non-verbal communication, and challenges with organization. However, the success of healthcare interactions largely depended on the interplay between patient- and provider-level factors, as well as the larger context in which patients were receiving care. Provider-level factors included providers' knowledge about autism in adults, incorrect assumptions about individual patients, willingness to allow written communication, use of accessible language, openness to providing other accommodations, and skill in appropriately incorporating supporters. System-level factors included the availability of supporters, complexity of the healthcare system, accessibility of healthcare facilities, and stigma about autism. Further efforts are needed to empower patients, adequately train providers, increase the accessibility of the healthcare system, and decrease discrimination. JF - Autism AU - Nicolaidis, Christina AU - Raymaker, Dora M AU - Ashkenazy, Elesia AU - McDonald, Katherine E AU - Dern, Sebastian AU - Baggs, Amelia EV AU - Kapp, Steven K AU - Weiner, Michael AU - Boisclair, W Cody AD - Portland State University, USA; Oregon Health & Science University, USA; Academic Autistic Spectrum Partnership in Research and Education, USA ; Portland State University, USA; Academic Autistic Spectrum Partnership in Research and Education, USA ; Academic Autistic Spectrum Partnership in Research and Education, USA ; Academic Autistic Spectrum Partnership in Research and Education, USA; Syracuse University, USA ; Academic Autistic Spectrum Partnership in Research and Education, USA; Indiana University Center for Health Services and Outcomes Research and Regenstrief Institute, Inc., USA; U.S. Department of Veterans Affairs, USA Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 824 EP - 831 CY - London PB - SAGE PUBLICATIONS, INC. VL - 19 IS - 7 SN - 1362-3613 KW - Psychology KW - adults KW - autism spectrum disorders KW - community-based participatory research KW - health services KW - qualitative research KW - Accessibility KW - Adults KW - Autistic children KW - Autistic spectrum disorders KW - Communication skills KW - Community based action research KW - Discrimination KW - Health care KW - Nonverbal communication KW - Openness KW - Participatory research KW - Patient care KW - Quality of care KW - Sensory stimulation KW - Stigmatization KW - Supporters KW - Verbal communication skills UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1865906282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Autism&rft.atitle=%22Respect+the+way+I+need+to+communicate+with+you%22%3A+Healthcare+experiences+of+adults+on+the+autism+spectrum&rft.au=Nicolaidis%2C+Christina%3BRaymaker%2C+Dora+M%3BAshkenazy%2C+Elesia%3BMcDonald%2C+Katherine+E%3BDern%2C+Sebastian%3BBaggs%2C+Amelia+EV%3BKapp%2C+Steven+K%3BWeiner%2C+Michael%3BBoisclair%2C+W+Cody&rft.aulast=Nicolaidis&rft.aufirst=Christina&rft.date=2015-10-01&rft.volume=19&rft.issue=7&rft.spage=824&rft.isbn=&rft.btitle=&rft.title=Autism&rft.issn=13623613&rft_id=info:doi/10.1177%2F1362361315576221 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2015 N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1177/1362361315576221 ER - TY - JOUR T1 - Children's liver chemistries vary with age and gender and require customized pediatric reference ranges. AN - 1712523163; 26190302 AB - Used to detect liver disease and injury, baseline liver chemistry distributions were evaluated by age and gender in children without known liver disease. Baseline liver chemistries [alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (TBIL)] were analyzed from 24 randomized controlled pediatric clinical trials. Using quantile regression, liver chemistry distributions were examined by age and gender; upper limit normal (ULN) ranges were compared to the 97.5th percentiles of the distributions for the specified ages and genders. 5410 subjects without known liver disease (0-18 years; 60% male) were studied. The median ALT varied little with age. In males age 5-18, the ALT 97.5th percentile increased from 34 to 63 IU/L. In both genders, the median and 97.5th percentile AST decreased with age. After age 9, ALP decreased. TBIL increased with age. Despite most liver chemistry 97.5th percentiles changing substantively with age and gender, the reference lab ULN generally changed minimally and did not correlate with the 97.5th percentile. Gender and age specific 97.5th percentile data should therefore be considered for the reference laboratory ULN in children to more accurately detect liver injury and disease. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Stirnadel-Farrant, Heide A AU - Galwey, Nicholas AU - Bains, Chanchal AU - Yancey, Caroline AU - Hunt, Christine M AD - Worldwide Epidemiology, GlaxoSmithKline, Stockley Park, UK. Electronic address: heide.a.stirnadel@gsk.com. ; Worldwide Epidemiology, GlaxoSmithKline, Stockley Park, UK. ; Department of Epidemiology, University of North Carolina, Gillings School of Global Public Health, Chapel Hill, NC, USA. ; Division of Gastroenterology, Duke University Medical Center, Durham, NC, USA; Durham Veterans Administration Medical Center, Durham, NC, USA. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 349 EP - 355 VL - 73 IS - 1 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Bilirubin KW - RFM9X3LJ49 KW - Index Medicus KW - Alkaline phosphatase KW - Laboratory reference ranges KW - Pediatric clinical trials KW - Liver chemistries KW - Alanine aminotransferase KW - Young Adult KW - Liver Diseases -- physiopathology KW - Reference Values KW - Alanine Transaminase -- metabolism KW - Humans KW - Infant, Newborn KW - Alkaline Phosphatase -- metabolism KW - Child KW - Liver Diseases -- metabolism KW - Child, Preschool KW - Infant KW - Aspartate Aminotransferases -- metabolism KW - Bilirubin -- metabolism KW - Adult KW - Adolescent KW - Liver Function Tests -- methods KW - Male KW - Female KW - Liver -- metabolism KW - Liver -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712523163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Children%27s+liver+chemistries+vary+with+age+and+gender+and+require+customized+pediatric+reference+ranges.&rft.au=Stirnadel-Farrant%2C+Heide+A%3BGalwey%2C+Nicholas%3BBains%2C+Chanchal%3BYancey%2C+Caroline%3BHunt%2C+Christine+M&rft.aulast=Stirnadel-Farrant&rft.aufirst=Heide&rft.date=2015-10-01&rft.volume=73&rft.issue=1&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.07.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-28 N1 - Date created - 2015-09-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.07.013 ER - TY - JOUR T1 - Targeting glutamine metabolism in myeloproliferative neoplasms. AN - 1701345628; 26227854 AB - JAK2(V617F) mutation can be detected in the majority of myeloproliferative neoplasm (MPN) patients. The JAK2 inhibitor Ruxolitinib is the first FDA-approved treatment for MPNs. However, its use is limited by various dose related toxicities. Here, we studied the metabolic state and glutamine metabolism of BaF3-hEPOR-JAK2V617F and BaF3-hEPOR-JAK2WT cells. We found that the JAK2(V617F)-mutant cells were associated with increased oxygen consumption rate and extracellular acidification rate than the JAK2(WT) cells and there was an increased glutamine metabolism in JAK2(V617F)-mutant cells compared to wild-type cells. Glutaminase (GLS), the key enzyme in glutamine metabolism, was upregulated in the JAK2(V617F)-mutant BaF3 cells compared to the JAK2(WT) BaF3 cells. In MPN patient peripheral blood CD34+ cells, GLS expression was increased in JAK2(V617F)-mutant progenitor cells compared to JAK2 wild-type progenitor cells from the same patients and GLS levels were increased at the time of disease progression compared to at earlier time points. Moreover, GLS inhibitor increased the growth inhibitory effect of Ruxolitinib in both JAK2(V617F)-mutant cell lines and peripheral blood CD34+ cells from MPN patients. Therefore, GLS inhibitor should be further explored to enhance the therapeutic effectiveness of JAK2 inhibitor and allow the administration of lower doses of the drug to avoid its toxicity. Copyright © 2015. Published by Elsevier Inc. JF - Blood cells, molecules & diseases AU - Zhan, Huichun AU - Ciano, Kristen AU - Dong, Katherine AU - Zucker, Stanley AD - Northport VA Medical Center, Northport, NY, USA; Department of Medicine, Stony Brook University, Stony Brook, NY, USA. Electronic address: Huichun.Zhan@va.gov. ; Northport VA Medical Center, Northport, NY, USA. ; Rice University and Baylor College of Medicine, Houston, TX, USA. ; Northport VA Medical Center, Northport, NY, USA; Department of Medicine, Stony Brook University, Stony Brook, NY, USA. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 241 EP - 247 VL - 55 IS - 3 KW - INCB018424 KW - 0 KW - Pyrazoles KW - Glutamine KW - 0RH81L854J KW - JAK2 protein, human KW - EC 2.7.10.2 KW - Janus Kinase 2 KW - Index Medicus KW - Myeloproliferative neoplasm KW - Glutaminase inhibitor KW - Cancer metabolism KW - JAK2 inhibitor KW - Pyrazoles -- pharmacology KW - Humans KW - Cell Line, Tumor KW - Up-Regulation KW - Mutation KW - Janus Kinase 2 -- antagonists & inhibitors KW - Glutamine -- metabolism KW - Janus Kinase 2 -- metabolism KW - Janus Kinase 2 -- genetics KW - Myeloproliferative Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701345628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood+cells%2C+molecules+%26+diseases&rft.atitle=Targeting+glutamine+metabolism+in+myeloproliferative+neoplasms.&rft.au=Zhan%2C+Huichun%3BCiano%2C+Kristen%3BDong%2C+Katherine%3BZucker%2C+Stanley&rft.aulast=Zhan&rft.aufirst=Huichun&rft.date=2015-10-01&rft.volume=55&rft.issue=3&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Blood+cells%2C+molecules+%26+diseases&rft.issn=1096-0961&rft_id=info:doi/10.1016%2Fj.bcmd.2015.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-13 N1 - Date created - 2015-08-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bcmd.2015.07.007 ER - TY - JOUR T1 - Dual use of VA and non-VA hospitals by Veterans with multiple hospitalizations. AN - 1718077507; 26416176 AB - Veterans who are hospitalized in both VA and non-VA hospitals within a short timespan may be at risk for fragmented or conflicting care. To determine the characteristics of these "dual users," we analyzed administrative hospital discharge data for VA-enrolled veterans of any age in seven states, including any VA or non-VA hospitalizations they had in 2004-2007. For VA enrollees in Arizona, Iowa, Louisiana, Florida, South Carolina, Pennsylvania, or New York in 2007, we merged 2004-2007 discharge data for all VA hospitalizations and all non-VA hospitalizations listed in state health department or hospital association databases. For patients hospitalized in 2007, we compared those younger or older than 65 years who had one or multiple hospitalizations during the year, split into users of VA hospitals, non-VA hospitals, or both ("dual users"), on demographics, priority for VA care, travel times, principal diagnoses, co-morbidities, lengths of stay, and prior (2004-2006) hospitalizations, using chi-square analysis or ANOVA. Multiply hospitalized patients were compared with multinomial logistic regressions to predict non-VA and dual use. Payers for non-VA hospitalizations also were compared across groups. Of unique inpatients in 2007, 38 % of those 65 or older were hospitalized more than once during the year, as were 32 % of younger patients; 3 and 8 %, respectively, were dual users. Dual users averaged the most index-year (3.7) and prior (1.5) hospitalizations, split evenly between VA and non-VA. They also had higher rates of admission for circulatory diseases, symptoms/signs/ill-defined conditions, and injury and poisoning, and more admissions for multiple diagnostic categories; among younger patients they had the highest rate of mental disorders admissions. Higher income, non-rural residence, greater time to VA care, lower VA priority, prior non-VA hospitalization, no prior VA hospitalization, and several medical categories predicted greater non-VA use. Among younger patients, however, mental disorders predicted more dual use but less exclusively non-VA use. Dual users' non-VA admissions were more likely than others' to be covered by payers other than Medicare or commercial insurance. Younger dual users require more medical and psychiatric treatment, and rely more on government funding sources. Effective care coordination for these inpatients might improve outcomes while reducing taxpayer burden. JF - BMC health services research AU - West, Alan N AU - Charlton, Mary E AU - Vaughan-Sarrazin, Mary AD - Research Service, VA Medical Center (10A5A), 215 N. Main St., White River Junction, Vermont, 05009, USA. alan.west@va.gov. ; Iowa City VA Health Care System, Comprehensive Access and Delivery Research and Evaluation (CADRE) Center, Iowa City, Iowa, USA. mary-charlton@uiowa.edu. ; Iowa City VA Health Care System, Comprehensive Access and Delivery Research and Evaluation (CADRE) Center, Iowa City, Iowa, USA. mary-vaughan-sarrazin@uiowa.edu. Y1 - 2015/09/29/ PY - 2015 DA - 2015 Sep 29 SP - 431 VL - 15 KW - Index Medicus KW - United States KW - Humans KW - Aged KW - Medicare -- economics KW - Travel -- economics KW - Aged, 80 and over KW - Logistic Models KW - United States Department of Veterans Affairs KW - Patient Discharge -- trends KW - Databases, Factual KW - Middle Aged KW - Inpatients KW - Female KW - Male KW - Mental Disorders -- economics KW - Veterans KW - Hospitals, Veterans -- utilization KW - Hospitalization -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718077507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+health+services+research&rft.atitle=Dual+use+of+VA+and+non-VA+hospitals+by+Veterans+with+multiple+hospitalizations.&rft.au=West%2C+Alan+N%3BCharlton%2C+Mary+E%3BVaughan-Sarrazin%2C+Mary&rft.aulast=West&rft.aufirst=Alan&rft.date=2015-09-29&rft.volume=15&rft.issue=&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=BMC+health+services+research&rft.issn=1472-6963&rft_id=info:doi/10.1186%2Fs12913-015-1069-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-10 N1 - Date created - 2015-09-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Rural Health. 2009 Summer;25(3):259-66 [19566611] Health Serv Res. 2009 Oct;44(5 Pt 1):1718-34 [19500162] Gen Hosp Psychiatry. 2009 Nov-Dec;31(6):589-91 [19892220] Health Serv Res. 2010 Jun;45(3):762-91 [20403056] Home Health Care Serv Q. 2010 Apr;29(2):91-104 [20635273] Psychiatr Serv. 2010 Oct;61(10):1035-8 [20889645] Med Care. 2011 Oct;49(10):911-7 [21685810] JAMA. 2012 Feb 22;307(8):789-90 [22357828] Mil Med. 2014 Nov;179(11):1236-43 [25373047] J Gen Intern Med. 1999 May;14(5):274-80 [10337036] Am J Med Qual. 1999 Jan-Feb;14(1):28-38 [10446661] J Healthc Manag. 2005 Mar-Apr;50(2):95-106; discussion 106-7 [15839324] Am J Public Health. 2005 Jul;95(7):1149-55 [15983270] BMC Health Serv Res. 2006;6:131 [17029643] Stroke. 2007 Feb;38(2):355-60 [17194888] Med Care. 2007 Mar;45(3):214-23 [17304078] BMC Health Serv Res. 2007;7:70 [17490488] Med Care. 2008 Mar;46(3):309-16 [18388846] J Gen Intern Med. 2009 Mar;24(3):305-11 [19101777] Soc Sci Med. 2000 Jun;50(12):1743-55 [10798329] Soc Sci Med. 1994 Jul;39(1):95-104 [8066492] Health Aff (Millwood). 1997 Jul-Aug;16(4):200-4 [9248165] Med Care. 1998 Jan;36(1):8-27 [9431328] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12913-015-1069-8 ER - TY - JOUR T1 - Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model. AN - 1716934775; 26291556 AB - Tissue engineering approaches may improve survival and functional benefits from human embryonic stem cell-derived cardiomyocyte transplantation, thereby potentially preventing dilative remodeling and progression to heart failure. Assessment of transport stability, long-term survival, structural organization, functional benefits, and teratoma risk of engineered heart muscle (EHM) in a chronic myocardial infarction model. We constructed EHMs from human embryonic stem cell-derived cardiomyocytes and released them for transatlantic shipping following predefined quality control criteria. Two days of shipment did not lead to adverse effects on cell viability or contractile performance of EHMs (n=3, P=0.83, P=0.87). One month after ischemia/reperfusion injury, EHMs were implanted onto immunocompromised rat hearts to simulate chronic ischemia. Bioluminescence imaging showed stable engraftment with no significant cell loss between week 2 and 12 (n=6, P=0.67), preserving ≤25% of the transplanted cells. Despite high engraftment rates and attenuated disease progression (change in ejection fraction for EHMs, -6.7±1.4% versus control, -10.9±1.5%; n>12; P=0.05), we observed no difference between EHMs containing viable and nonviable human cardiomyocytes in this chronic xenotransplantation model (n>12; P=0.41). Grafted cardiomyocytes showed enhanced sarcomere alignment and increased connexin 43 expression at 220 days after transplantation. No teratomas or tumors were found in any of the animals (n=14) used for long-term monitoring. EHM transplantation led to high engraftment rates, long-term survival, and progressive maturation of human cardiomyocytes. However, cell engraftment was not correlated with functional improvements in this chronic myocardial infarction model. Most importantly, the safety of this approach was demonstrated by the lack of tumor or teratoma formation. © 2015 American Heart Association, Inc. JF - Circulation research AU - Riegler, Johannes AU - Tiburcy, Malte AU - Ebert, Antje AU - Tzatzalos, Evangeline AU - Raaz, Uwe AU - Abilez, Oscar J AU - Shen, Qi AU - Kooreman, Nigel G AU - Neofytou, Evgenios AU - Chen, Vincent C AU - Wang, Mouer AU - Meyer, Tim AU - Tsao, Philip S AU - Connolly, Andrew J AU - Couture, Larry A AU - Gold, Joseph D AU - Zimmermann, Wolfram H AU - Wu, Joseph C AD - From the Division of Cardiology, Department of Medicine, Stanford Cardiovascular Institute (J.R., A.E., E.T., U.R., O.J.A., O.S., N.G.K., E.N., M.W., P.S.T., J.D.G., J.C.W.) and Department of Pathology (A.J.C.), Stanford University School of Medicine, CA; Department for Research and Development, Veterans Administration Palo Alto Health Care System, CA (P.S.T.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., T.M., W.H.Z.); and Center for Biomedicine and Genetics (V.C.C., L.A.C.) and Center for Applied Technology Development, Beckman Research Institute (A.J.C.), City of Hope, Duarte, CA. ; From the Division of Cardiology, Department of Medicine, Stanford Cardiovascular Institute (J.R., A.E., E.T., U.R., O.J.A., O.S., N.G.K., E.N., M.W., P.S.T., J.D.G., J.C.W.) and Department of Pathology (A.J.C.), Stanford University School of Medicine, CA; Department for Research and Development, Veterans Administration Palo Alto Health Care System, CA (P.S.T.); Institute of Pharmacology, Heart Research Center, University Medical Center, Georg-August-University and German Center for Cardiovascular Research, Göttingen, Germany (M.T., T.M., W.H.Z.); and Center for Biomedicine and Genetics (V.C.C., L.A.C.) and Center for Applied Technology Development, Beckman Research Institute (A.J.C.), City of Hope, Duarte, CA. joewu@stanford.edu w.zimmermann@med.uni-goettingen.de. Y1 - 2015/09/25/ PY - 2015 DA - 2015 Sep 25 SP - 720 EP - 730 VL - 117 IS - 8 KW - Biomarkers KW - 0 KW - Connexin 43 KW - GJA1 protein, human KW - Immunosuppressive Agents KW - Index Medicus KW - tissue engineering KW - cardiac function tests KW - myocardial infarction KW - myocardial ischemia KW - cell survival KW - cardiac MRI KW - transplantation KW - Heterografts KW - Animals KW - Humans KW - Cell Differentiation KW - Disease Models, Animal KW - Cell Survival KW - Immunosuppressive Agents -- pharmacology KW - Rats, Sprague-Dawley KW - Transfection KW - Rats, Nude KW - Myocardial Contraction KW - Biomarkers -- metabolism KW - Connexin 43 -- metabolism KW - Time Factors KW - Cell Line KW - Male KW - Stroke Volume KW - Papillary Muscles -- transplantation KW - Myocardial Infarction -- pathology KW - Myocardial Infarction -- surgery KW - Myocytes, Cardiac -- immunology KW - Papillary Muscles -- metabolism KW - Heart Transplantation -- methods KW - Papillary Muscles -- immunology KW - Myocytes, Cardiac -- pathology KW - Tissue Engineering -- methods KW - Myocardial Infarction -- physiopathology KW - Myocytes, Cardiac -- transplantation KW - Heart Transplantation -- adverse effects KW - Myocardial Infarction -- metabolism KW - Embryonic Stem Cells -- metabolism KW - Myocardial Infarction -- immunology KW - Embryonic Stem Cells -- transplantation KW - Papillary Muscles -- physiopathology KW - Embryonic Stem Cells -- immunology KW - Graft Survival KW - Papillary Muscles -- pathology KW - Myocytes, Cardiac -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1716934775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation+research&rft.atitle=Human+Engineered+Heart+Muscles+Engraft+and+Survive+Long+Term+in+a+Rodent+Myocardial+Infarction+Model.&rft.au=Riegler%2C+Johannes%3BTiburcy%2C+Malte%3BEbert%2C+Antje%3BTzatzalos%2C+Evangeline%3BRaaz%2C+Uwe%3BAbilez%2C+Oscar+J%3BShen%2C+Qi%3BKooreman%2C+Nigel+G%3BNeofytou%2C+Evgenios%3BChen%2C+Vincent+C%3BWang%2C+Mouer%3BMeyer%2C+Tim%3BTsao%2C+Philip+S%3BConnolly%2C+Andrew+J%3BCouture%2C+Larry+A%3BGold%2C+Joseph+D%3BZimmermann%2C+Wolfram+H%3BWu%2C+Joseph+C&rft.aulast=Riegler&rft.aufirst=Johannes&rft.date=2015-09-25&rft.volume=117&rft.issue=8&rft.spage=720&rft.isbn=&rft.btitle=&rft.title=Circulation+research&rft.issn=1524-4571&rft_id=info:doi/10.1161%2FCIRCRESAHA.115.306985 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-31 N1 - Date created - 2015-09-25 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Biotechnol Bioeng. 2000 Apr 5;68(1):106-14 [10699878] N Engl J Med. 2003 May 15;348(20):2007-18 [12748317] Am J Cardiol. 1991 Apr 15;67(9):897-9 [2011993] Circulation. 2006 Feb 21;113(7):1005-14 [16476845] Nat Med. 2006 Apr;12(4):452-8 [16582915] Nat Med. 2006 Apr;12(4):459-65 [16582917] Circ Res. 2007 Feb 2;100(2):263-72 [17218605] Nat Biotechnol. 2007 Sep;25(9):1015-24 [17721512] Heart. 2007 Oct;93(10):1278-84 [17566061] J Am Coll Cardiol. 2007 Nov 6;50(19):1884-93 [17980256] Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2604-13 [18408133] Circulation. 2008 Sep 30;118(14 Suppl):S121-9 [18824743] Circulation. 2008 Sep 30;118(14 Suppl):S145-52 [18824746] Toxicol Pathol. 2009 Apr;37(3):348-50 [19380844] Stem Cell Res. 2007 Oct;1(1):9-24 [19383383] Tissue Eng Part A. 2009 Jun;15(6):1211-22 [19063661] Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16568-73 [19805339] PLoS One. 2009;4(12):e8443 [20046878] J Magn Reson Imaging. 2010 Oct;32(4):869-77 [20882617] J Mol Cell Cardiol. 2010 Dec;49(6):941-9 [20854826] Nature. 2011 May 19;473(7347):326-35 [21593865] Circ Res. 2011 Jun 24;109(1):47-59 [21597009] Circulation. 2011 Nov 15;124(20):2275-7 [22083149] Cell Stem Cell. 2012 Jan 6;10(1):16-28 [22226352] Stem Cell Res. 2012 May;8(3):388-402 [22459095] Nature. 2012 Sep 13;489(7415):322-5 [22864415] Eur J Heart Fail. 2013 Jan;15(1):23-35 [23243122] J Clin Invest. 2013 Mar;123(3):1285-98 [23434590] Eur Heart J. 2013 Apr;34(15):1134-46 [23103664] Biomaterials. 2013 Jul;34(23):5813-20 [23642535] Lancet. 2013 Aug 17;382(9892):644-57 [23953388] Circ Res. 2013 Sep 13;113(7):922-32 [24030022] Stem Cells. 2013 Nov;31(11):2354-63 [24038578] Stem Cell Reports. 2013;1(5):387-96 [24286027] Circ Res. 2014 Jan 3;114(1):21-7 [24385505] FASEB J. 2014 Feb;28(2):644-54 [24174427] PLoS One. 2014;9(4):e94722 [24733085] Nature. 2014 Jun 12;510(7504):273-7 [24776797] Methods Mol Biol. 2014;1181:167-76 [25070336] Circulation. 2014 Sep 9;130(11 Suppl 1):S77-86 [25200059] Sci Rep. 2014;4:6716 [25336194] Eur Heart J. 2015 Mar 21;36(12):743-50 [24835485] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1161/CIRCRESAHA.115.306985 ER - TY - JOUR T1 - A rare case of immune reconstitution inflammatory syndrome presenting as secondary syphilis AN - 1765978956; PQ0002584109 AB - Immune reconstitution syndrome has rarely been reported in the context of syphilis infection. We report a patient with AIDS (CD4 42 cells/mm 3 , viral load 344,000 cp/ml), treated previously for secondary syphilis and started on an integrase inhibitor-based single-tablet antiretroviral treatment regimen. After four weeks of antiretroviral treatment, he presented with non-tender, non-blanching erythematous nodules on his chest, an elevated rapid plasma reagin (1:1024) and immune reconstitution (CD4 154 cells/mm 3 , HIV-RNA 130 cp/ml). A detailed workup to exclude opportunistic infections including secondary and neurosyphilis was performed. The patient was continued on antiretroviral treatment and treated empirically for neurosyphilis given cerebrospinal lymphocytosis and dermatopathology suggesting treponemal antigen-driven B-cell hyperplasia. We favour a diagnosis of immune reconstitution in association with prior syphilis infection attributable to rapid and potent immune restoration afforded by integrase inhibitors. JF - International Journal of STD & AIDS AU - Khatri, Asma AU - Skalweit, Marion J AD - 1 .Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA, marion.skalweit@va.gov Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 749 EP - 751 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 United States VL - 26 IS - 10 SN - 0956-4624, 0956-4624 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Human immunodeficiency virus KW - AIDS KW - immune reconstitution syndrome KW - IRIS KW - syphilis KW - Treponema pallidum KW - antiretroviral therapy KW - HIV integrase inhibitors KW - Acquired immune deficiency syndrome KW - Lymphocytes B KW - Infection KW - Chest KW - Antiretroviral agents KW - Nodules KW - Inflammation KW - Opportunist infection KW - Immune reconstitution KW - Hyperplasia KW - CD4 antigen KW - Lymphocytosis KW - Antiviral agents KW - Reagin KW - Neurosyphilis KW - Syphilis KW - Sexually transmitted diseases KW - Integrase KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765978956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=A+rare+case+of+immune+reconstitution+inflammatory+syndrome+presenting+as+secondary+syphilis&rft.au=Khatri%2C+Asma%3BSkalweit%2C+Marion+J&rft.aulast=Khatri&rft.aufirst=Asma&rft.date=2015-09-01&rft.volume=26&rft.issue=10&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/10.1177%2F0956462414553013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 8 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Lymphocytes B; Chest; Nodules; Opportunist infection; Inflammation; Immune reconstitution; CD4 antigen; Hyperplasia; Lymphocytosis; Antiviral agents; Reagin; Neurosyphilis; Syphilis; Integrase; Infection; Antiretroviral agents; Sexually transmitted diseases; Human immunodeficiency virus; Treponema pallidum DO - http://dx.doi.org/10.1177/0956462414553013 ER - TY - JOUR T1 - Trajectories of Lifetime Comorbid Alcohol and Other Drug Use Disorders Through Midlife AN - 1761674707; 201603922 AB - Objective: Very few studies have examined the developmental nature of comorbid alcohol use disorders and drug use disorders (AUD-DUD). The current study sought to extend our understanding of the nature of AUD-DUD comorbidity by characterizing the developmental course of AUD-DUD comorbidity, determining the degree to which the two disorders occur during the same period, and eliciting differences in AUD-DUD trajectories over the life course. Method: Vietnam-era male veterans and matched civilians provided retrospective accounts of alcohol- and other drug-related experiences spanning 25 years. Concurrent growth mixture modeling was used to describe the course of AUD-DUD lifetime comorbidity. Results: Five trajectories were identified based on the probabilities of diagnosing with AUD-DUD: substance switching (increasing AUD, decreasing DUD); young adult (both AUD and DUD decreasing rapidly after young adulthood); severe nonchronic (both AUD and DUD decreasing slowly in the third decade of life); severe chronic alcohol-severe nonchronic drug (AUD remains high and DUD decreases in the fourth decade); and young adult alcohol-severe chronic drug (decreasing AUD in the second decade and DUD remains high). Conclusions: For the majority of this sample, substance use disorders continued or worsened through adulthood, indicating a problem that extends far beyond young adulthood. Demographic characteristics differed among the trajectories; however, psychiatric diagnoses did not differ except for the number of years with diagnoses of antisocial personality disorder. Subthreshold symptoms in adulthood may be present for a significant period before diagnosis, making this period important for intervention and prevention. Integration of efforts into healthcare, employment, and public policy will help target those at highest risk. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Upah, Roxanne AU - Jacob, Theodore AU - Price, Rumi Kato AD - Family Research Center, Veterans Affairs Palo Alto Healthcare System, Menlo Park, California roxanne.upah@va.gov Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 721 EP - 732 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 76 IS - 5 SN - 1937-1888, 1937-1888 KW - Veterans KW - Symptoms KW - Alcohol Abuse KW - Males KW - Intervention KW - Young Adults KW - Comorbidity KW - Health Care Services KW - Drug Abuse KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761674707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Trajectories+of+Lifetime+Comorbid+Alcohol+and+Other+Drug+Use+Disorders+Through+Midlife&rft.au=Upah%2C+Roxanne%3BJacob%2C+Theodore%3BPrice%2C+Rumi+Kato&rft.aulast=Upah&rft.aufirst=Roxanne&rft.date=2015-09-01&rft.volume=76&rft.issue=5&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Comorbidity; Drug Abuse; Young Adults; Health Care Services; Symptoms; Intervention; Veterans; Alcohol Abuse; Males ER - TY - JOUR T1 - Concomitant cannabis abuse/dependence in patients treated with opioids for non-cancer pain AN - 1707758382 AB - Background and Objectives Cannabis use is common among patients taking prescription opioids, although rates of concomitant cannabis use disorder (CUD) have been largely unexamined. CUD may increase safety risks in those taking opioid pain medications but it is unknown whether cannabis and opioids function as substitutes (cannabis use is associated with less prescription opioid use), or rather as complements (cannabis is associated with increased use of prescription opioids). Methods We examined rates of CUD in a national sample of Veterans Health Administration (VHA) patients ( n=1,316,464) with non-cancer pain diagnoses receiving opioid medications in fiscal year 2012. Using bivariate analysis to identify potentially confounding variables associated with CUD (eg, psychotropic medication, other substance use disorders) in this population, we then utilized logistic regression to examine rates of cannabis use disorder among individuals receiving different numbers of opioid prescriptions (0, 1–2, 3–10, 11–19, 20+). Results Descriptive analysis, largely confirmed by logistic regression, demonstrated that greater numbers of prescription opioid fills were associated with greater likelihood of CUD. This relationship was reduced somewhat for those receiving the most opioid prescriptions (20+) in the logistic regression, which controlled for potentially confounding variables. Discussion and Conclusions These results warrant increased attention to CUDs among patients receiving numerous opioid prescriptions. Increasing legalization of cannabis is likely to further increase use and abuse of cannabis in patients prescribed opioids. Scientific Significance These findings suggest that clinicians should be alert to concomitant CUD and prescription opioid use, as these substances appear to complement each other. (Am J Addict 2015;24:538–545) JF - The American Journal on Addictions AU - Hefner, Kathryn AU - Sofuoglu, Mehmet AU - Rosenheck, Robert AD - Veterans Health Administration Mental Illness Research, Education and Clinical Center (MIRECC), West Haven, Connecticut., Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut. ; Veterans Health Administration Mental Illness Research, Education and Clinical Center (MIRECC), West Haven, Connecticut.; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut. Y1 - 2015/09// PY - 2015 DA - Sep 2015 SP - 538 EP - 545 CY - Hoboken PB - Wiley Subscription Services, Inc. VL - 24 IS - 6 SN - 1055-0496 KW - Medical Sciences--Psychiatry And Neurology KW - Addicts KW - Prescribed KW - Prescriptions KW - Psychotropic drugs KW - Safety KW - Substance abuse disorders KW - Veterans KW - Canabis KW - Cancer KW - Cannabis KW - Drug dependency KW - Drugs KW - Legalization KW - Military hospitals KW - Opioids KW - Pain UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1707758382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+and+Adolescent+Social+Work+Journal&rft.atitle=Attachment+Representations+and+Parental+Memories+of+Incarcerated+Fathers&rft.au=Fairchild%2C+Sherry+R&rft.aulast=Fairchild&rft.aufirst=Sherry&rft.date=2009-08-01&rft.volume=26&rft.issue=4&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Child+and+Adolescent+Social+Work+Journal&rft.issn=07380151&rft_id=info:doi/10.1007%2Fs10560-009-0180-2 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Veterans Health Administration N1 - Date revised - 2015-09-22 N1 - Last updated - 2016-05-16 DO - http://dx.doi.org/10.1111/ajad.12260 ER - TY - JOUR T1 - Deliberate Microbial Infection Research Reveals Limitations to Current Safety Protections of Healthy Human Subjects AN - 1827923271; PQ0001877941 AB - Here we identify approximately 40,000 healthy human volunteers who were intentionally exposed to infectious pathogens in clinical research studies dating from late World War II to the early 2000s. Microbial challenge experiments continue today under contemporary human subject research requirements. In fact, we estimated 4,000 additional volunteers who were experimentally infected between 2010 and the present day. We examine the risks and benefits of these experiments and present areas for improvement in protections of participants with respect to safety. These are the absence of maximum limits to risk and the potential for institutional review boards to include questionable benefits to subjects and society when weighing the risks and benefits of research protocols. The lack of a duty of medical care by physician-investigators to research subjects is likewise of concern. The transparency of microbial challenge experiments and the safety concerns raised in this work may stimulate further dialogue on the risks to participants of human experimentation. JF - Science and Engineering Ethics AU - Evers, David L AU - Fowler, Carol B AU - Mason, Jeffrey T AU - Mimnall, Rebecca K AD - Veterans Affairs Maryland Health Care System, Research Service, 10 North Greene Street, Baltimore, MD, 21201, USA, david.evers2@va.gov Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 1049 EP - 1064 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 21 IS - 4 SN - 1353-3452, 1353-3452 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cost-benefit analysis KW - Dating KW - Ethics KW - Pathogens KW - Infection KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827923271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+and+Engineering+Ethics&rft.atitle=Deliberate+Microbial+Infection+Research+Reveals+Limitations+to+Current+Safety+Protections+of+Healthy+Human+Subjects&rft.au=Evers%2C+David+L%3BFowler%2C+Carol+B%3BMason%2C+Jeffrey+T%3BMimnall%2C+Rebecca+K&rft.aulast=Evers&rft.aufirst=David&rft.date=2015-08-01&rft.volume=21&rft.issue=4&rft.spage=1049&rft.isbn=&rft.btitle=&rft.title=Science+and+Engineering+Ethics&rft.issn=13533452&rft_id=info:doi/10.1007%2Fs11948-014-9579-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 67 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Cost-benefit analysis; Ethics; Dating; Pathogens; Infection DO - http://dx.doi.org/10.1007/s11948-014-9579-z ER - TY - JOUR T1 - Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV beta -lactamases with single amino acid substitutions in the Omega -loop AN - 1712569374; PQ0001944540 AB - Objectives The objective of this study was to explore the activity of ceftazidime and ceftazidime/avibactam against a collection of isogenic strains of Escherichia coli DH10B possessing SHV and KPC beta -lactamases containing single amino acid substitutions in the Omega -loop (residues 164-179). Methods Ceftazidime and ceftazidime/avibactam MICs were determined by the agar dilution method for a panel of isogenic E. coli strains expressing SHV-1 and KPC-2 with amino acid substitutions at positions 164, 167, 169 or 179. Two KPC-2 beta -lactamase variants that possessed elevated MICs of ceftazidime/avibactam were selected for further biochemical analyses. Results Avibactam restored susceptibility to ceftazidime for all Omega -loop variants of SHV-1 with MICs 8 mg/L. beta -Lactamase kinetics showed that the Asp179Asn variant of KPC-2 demonstrated enhanced kinetic properties against ceftazidime. The K sub(i app), k sub(2)/K and k sub(off) of the Arg164Ala and Asp179Asn variant KPC-2 beta -lactamases indicated that avibactam effectively inhibited these enzymes. Conclusions Several KPC-2 variants demonstrating ceftazidime resistance as a result of single amino acid substitutions in the Omega -loop were not susceptible to ceftazidime/avibactam (MICs >8 mg/L). We hypothesize that this observation is due to the stabilizing interactions (e.g. hydrogen bonds) of ceftazidime within the active site of variant beta -lactamases that prevent avibactam from binding to and inhibiting the beta -lactamase. As ceftazidime/avibactam is introduced into the clinic, monitoring for new KPC-2 variants that may exhibit increased ceftazidime kinetics as well as resistance to this novel antibiotic combination will be important. JF - Journal of Antimicrobial Chemotherapy AU - Winkler, Marisa L AU - Papp-Wallace, Krisztina M AU - Bonomo, Robert A AD - Corresponding author. Tel: +1-216-791-3800, ext. 4801; , robert.bonomo@va.gov Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 2279 EP - 2286 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 70 IS - 8 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - beta -lactamase inhibitors KW - extended-spectrum beta -lactamases KW - ESBLs KW - antibiotic resistance KW - Ceftazidime KW - Agar KW - beta -Lactamase KW - Amino acid substitution KW - Hydrogen bonding KW - Kinetics KW - Escherichia coli KW - Enzymes KW - Antibiotics KW - Minimum inhibitory concentration KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712569374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Activity+of+ceftazidime%2Favibactam+against+isogenic+strains+of+Escherichia+coli+containing+KPC+and+SHV+beta+-lactamases+with+single+amino+acid+substitutions+in+the+Omega+-loop&rft.au=Winkler%2C+Marisa+L%3BPapp-Wallace%2C+Krisztina+M%3BBonomo%2C+Robert+A&rft.aulast=Winkler&rft.aufirst=Marisa&rft.date=2015-08-01&rft.volume=70&rft.issue=8&rft.spage=2279&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkv094 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Ceftazidime; Agar; Amino acid substitution; beta -Lactamase; Hydrogen bonding; Kinetics; Enzymes; Antibiotics; Minimum inhibitory concentration; Escherichia coli DO - http://dx.doi.org/10.1093/jac/dkv094 ER - TY - JOUR T1 - Aerobactin, but Not Yersiniabactin, Salmochelin, or Enterobactin, Enables the Growth/Survival of Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Ex Vivo and In Vivo AN - 1709184170; PQ0001900848 AB - The siderophore aerobactin is the dominant siderophore produced by hypervirulent Klebsiella pneumoniae (hvKP) and was previously shown to be a major virulence factor in systemic infection. However, strains of hvKP commonly produce the additional siderophores yersiniabactin, salmochelin, and enterobactin. The roles of these siderophores in hvKP infection have not been optimally defined. To that end, site-specific gene disruptions were created in hvKP1 (wild type), resulting in the generation of hvKP1 Delta iucA (aerobactin deficient), hvKP1 Delta iroB (salmochelin deficient), hvKP1 Delta entB (enterobactin and salmochelin deficient), hvKP1 Delta irp2 (yersiniabactin deficient), and hvKP1 Delta entB Delta irp2 (enterobactin, salmochelin, and yersiniabactin deficient). The growth/survival of these constructs was compared to that of their wild-type parent hvKP1 ex vivo in human ascites fluid, human serum, and human urine and in vivo in mouse systemic infection and pulmonary challenge models. Interestingly, in contrast to aerobactin, the inability to produce enterobactin, salmochelin, or yersiniabactin individually or in combination did not decrease the ex vivo growth/survival in human ascites or serum or decrease virulence in the in vivo infection models. Surprisingly, none of the siderophores increased growth in human urine. In human ascites fluid supplemented with exogenous siderophores, siderophores increased the growth of hvKP1 Delta iucA, with the relative activity being enterobactin > aerobactin > yersiniabactin > salmochelin, suggesting that the contribution of aerobactin to virulence is dependent on both innate biologic activity and quantity produced. Taken together, these data confirm and extend a role for aerobactin as a critical virulence factor for hvKP. Since it appears that aerobactin production is a defining trait of hvKP strains, this factor is a potential antivirulence target. JF - Infection and Immunity AU - Russo, Thomas A AU - Olson, Ruth AU - MacDonald, Ulrike AU - Beanan, Janet AU - Davidson, Bruce A AD - Veterans Administration Western New York Healthcare System, Buffalo, New York, USA, trusso@acsu.buffalo.edu. Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 3325 EP - 3333 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 83 IS - 8 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Data processing KW - Gene disruption KW - virulence factors KW - aerobactin KW - Disseminated infection KW - Animal models KW - Survival KW - Models KW - Siderophores KW - Lung KW - Urine KW - Ascites KW - Enterobactin KW - Klebsiella pneumoniae KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709184170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Aerobactin%2C+but+Not+Yersiniabactin%2C+Salmochelin%2C+or+Enterobactin%2C+Enables+the+Growth%2FSurvival+of+Hypervirulent+%28Hypermucoviscous%29+Klebsiella+pneumoniae+Ex+Vivo+and+In+Vivo&rft.au=Russo%2C+Thomas+A%3BOlson%2C+Ruth%3BMacDonald%2C+Ulrike%3BBeanan%2C+Janet%3BDavidson%2C+Bruce+A&rft.aulast=Russo&rft.aufirst=Thomas&rft.date=2015-08-01&rft.volume=83&rft.issue=8&rft.spage=3325&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00430-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 47 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Data processing; aerobactin; virulence factors; Gene disruption; Disseminated infection; Animal models; Survival; Siderophores; Models; Ascites; Urine; Lung; Enterobactin; Klebsiella pneumoniae DO - http://dx.doi.org/10.1128/IAI.00430-15 ER - TY - JOUR T1 - Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™. AN - 1701405838; 25988394 AB - Polypharmacy is common, and may modify mechanisms of drug-induced liver injury. We examined the effect of these drug-drug interactions on liver safety reports of four drugs highly associated with hepatotoxicity. In the WHO VigiBase™, liver event reports were examined for acetaminophen, isoniazid, valproic acid, and amoxicillin/clavulanic acid. Then, we evaluated the liver event reporting frequency of these 4 drugs in the presence of co-reported medications. Each of the 4 primary drugs was reported as having more than 2000 liver events, and co-reported with more than 600 different medications. Overall, the effect of 2275 co-reported drugs (316 drug classes) on the reporting frequency was analyzed. Decreased liver event reporting frequency was associated with 245 drugs/122 drug classes, including anti-TNFα, opioids, and folic acid. Increased liver event reporting frequency was associated with 170 drugs/82 drug classes; in particular, halogenated hydrocarbons, carboxamides, and bile acid sequestrants. After adjusting for age, gender, and other co-reported drug classes, multiple co-reported drug classes were significantly associated with decreased/increased liver event reporting frequency in a drug-specific/unspecific manner. In conclusion, co-reported medications were associated with changes in the liver event reporting frequency of drugs commonly associated with hepatotoxicity, suggesting that comedications may modify drug hepatic safety. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Suzuki, Ayako AU - Yuen, Nancy A AU - Ilic, Katarina AU - Miller, Richard T AU - Reese, Melinda J AU - Brown, H Roger AU - Ambroso, Jeffrey I AU - Falls, J Gregory AU - Hunt, Christine M AD - Gastroenterology, Central Arkansas Veterans Healthcare System and Gastroenterology and Hepatology, Univ. of Arkansas for Med. Sciences, Little Rock, AR, United States. Electronic address: asuzuki@uams.edu. ; Clinical Safety, GlaxoSmithKline, Research Triangle Park, NC, United States. ; Pharmacovigilance and Risk Management, Raptor Pharmaceuticals, CA, United States. ; Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC, United States. ; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, United States. ; Gastroenterology, Duke University Medical Center and Durham Veterans Administration Medical Center, Durham, NC, United States. Electronic address: Christine.Hunt@va.gov. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 481 EP - 490 VL - 72 IS - 3 KW - Acetaminophen KW - 362O9ITL9D KW - Valproic Acid KW - 614OI1Z5WI KW - Amoxicillin-Potassium Clavulanate Combination KW - 74469-00-4 KW - Isoniazid KW - V83O1VOZ8L KW - Index Medicus KW - Quantitative signal detection methods KW - Concomitant medications KW - Hepatotoxicity KW - Spontaneous adverse event reporting system KW - Drug-induced liver injury KW - World Health Organization KW - Data Mining KW - Acetaminophen -- adverse effects KW - Databases, Factual KW - Valproic Acid -- adverse effects KW - Isoniazid -- adverse effects KW - Amoxicillin-Potassium Clavulanate Combination -- adverse effects KW - Drug Interactions KW - Chemical and Drug Induced Liver Injury -- etiology KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701405838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Comedications+alter+drug-induced+liver+injury+reporting+frequency%3A+Data+mining+in+the+WHO+VigiBase%E2%84%A2.&rft.au=Suzuki%2C+Ayako%3BYuen%2C+Nancy+A%3BIlic%2C+Katarina%3BMiller%2C+Richard+T%3BReese%2C+Melinda+J%3BBrown%2C+H+Roger%3BAmbroso%2C+Jeffrey+I%3BFalls%2C+J+Gregory%3BHunt%2C+Christine+M&rft.aulast=Suzuki&rft.aufirst=Ayako&rft.date=2015-08-01&rft.volume=72&rft.issue=3&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-24 N1 - Date created - 2015-08-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Hepatology. 2014 Sep;60(3):1015-22 [24799086] Hepatology. 2014 Oct;60(4):1399-408 [25043597] Gastroenterology. 2000 Feb;118(2):422-30 [10648470] Hepatology. 2000 Mar;31(3):562-71 [10706543] Pharmacoepidemiol Drug Saf. 2003 Sep;12(6):517-21 [14513665] Br J Clin Pharmacol. 2004 Jul;58(1):71-80 [15206996] BMJ. 2004 Jul 3;329(7456):15-9 [15231615] J Am Soc Nephrol. 2004 Aug;15(8):2152-60 [15284300] J Perinatol. 1992 Jun;12(2):107-11 [1522425] Toxicol Appl Pharmacol. 1993 Feb;118(2):159-68 [8382844] J Hepatol. 1994 Jun;20(6):792-6 [7930480] Blood. 1996 Apr 15;87(8):3170-8 [8605331] Hepatology. 2000 Dec;32(6):1309-16 [11093738] J Nutr. 2001 Jan;131(1):33-8 [11208935] Hepatology. 2002 Aug;36(2):451-5 [12143055] JAMA. 2003 Mar 5;289(9):1107-16 [12622580] Life Sci. 1996;59(14):1141-7 [8831801] Neurochem Res. 1996 Nov;21(11):1375-86 [8947928] J Neuroimmunol. 1998 Mar 15;83(1-2):63-9 [9610674] Cell Physiol Biochem. 2005;15(1-4):69-76 [15665517] Arch Intern Med. 2005 Mar 14;165(5):567-73 [15767534] Drug Saf. 2005;28(11):981-1007 [16231953] Dig Liver Dis. 2006 Jan;38(1):33-8 [16054882] JAMA. 2006 Jul 5;296(1):87-93 [16820551] Hepatology. 2006 Oct;44(4):850-6 [17006920] J Hepatol. 2007 Feb;46(2):322-9 [17156885] Clin Liver Dis. 2007 Aug;11(3):507-24, vi [17723917] Arch Intern Med. 2007 Sep 10;167(16):1752-9 [17846394] Biochem Pharmacol. 2007 Dec 3;74(11):1665-76 [17897632] J Altern Complement Med. 2007 Nov;13(9):997-1006 [18047447] Dig Dis Sci. 2008 Jul;53(7):1977-82 [18392678] Hepatology. 2008 Jun;47(6):2003-9 [18454504] Drug Metab Dispos. 2009 Jan;37(1):229-36 [18838507] JAMA. 2008 Dec 24;300(24):2867-78 [19109115] World J Gastroenterol. 2009 Apr 14;15(14):1677-89 [19360911] Clin Gastroenterol Hepatol. 2009 Aug;7(8):882-8 [19362607] Clin Exp Immunol. 2009 Jul;157(1):27-34 [19659767] Acta Pharmacol Sin. 2009 Nov;30(11):1522-8 [19890360] Semin Liver Dis. 2010 May;30(2):134-46 [20422496] Drug Saf. 2010 Jun 1;33(6):503-22 [20486732] Mol Med. 2010 Jul-Aug;16(7-8):254-61 [20379612] Toxicol Pathol. 2010 Aug;38(5):715-29 [20551477] Toxicol Sci. 2010 Dec;118(2):485-500 [20829430] Hepatology. 2010 Dec;52(6):2065-76 [20949552] Respir Res. 2011;12:24 [21352583] Nat Rev Genet. 2011 Jun;12(6):417-28 [21587298] Clin Pharmacol Ther. 2011 Jun;89(6):902-7 [21508940] Thyroid. 2011 Jun;21(6):655-62 [21563917] Clin Pharmacol Ther. 2011 Jul;90(1):133-42 [21613990] Gastroenterology. 2011 Jul;141(1):338-47 [21570397] Toxicol Sci. 2012 Jan;125(1):126-33 [21984482] Drug Metab Rev. 2012 Feb;44(1):34-87 [21892896] Chem Res Toxicol. 2012 Oct 15;25(10):2067-82 [22931300] Clin Exp Allergy. 2013 Mar;43(3):344-52 [23414543] Pharmacol Rev. 2013 Apr;65(2):779-808 [23476052] Trends Pharmacol Sci. 2013 Apr;34(4):243-53 [23453390] Crit Rev Oncol Hematol. 2013 Nov;88(2):404-15 [23786843] Toxicol Sci. 2013 Nov;136(1):216-41 [23956101] Nucleic Acids Res. 2014 Jan;42(Database issue):D1091-7 [24203711] Eur J Clin Pharmacol. 2014 Apr;70(4):501-3 [24384565] Drug Metab Dispos. 2014 Apr;42(4):744-50 [24464804] Ann Pharmacother. 2003 Jul-Aug;37(7-8):1117-23 [12841826] Arch Surg. 2003 Aug;138(8):852-8 [12912743] Hepatology. 2003 Sep;38(3):664-73 [12939593] Gastroenterology. 2014 Jul;147(1):96-108.e4 [24681128] Arch Toxicol. 2014 Jul;88(7):1439-49 [24958025] Am J Gastroenterol. 2014 Jul;109(7):950-66; quiz 967 [24935270] Erratum In: Regul Toxicol Pharmacol. 2015 Oct;73(1):348 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.05.004 ER - TY - JOUR T1 - FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice. AN - 1700685795; 26092866 AB - Alcohol consumption leads to adipose tissue lipoatrophy and mobilization of FFAs, which contributes to hepatic fat accumulation in alcoholic liver disease. This study aimed to investigate the role of fibroblast growth factor (FGF)21, a metabolic regulator, in the regulation of chronic-binge alcohol-induced adipose tissue lipolysis. FGF21 KO mice were subjected to chronic-binge alcohol exposure, and epididymal white adipose tissue lipolysis and liver steatosis were investigated. Alcohol exposure caused adipose intracellular cAMP elevation and activation of lipolytic enzymes, leading to FFA mobilization in both WT and FGF21 KO mice. However, alcohol-induced systemic elevation of catecholamine, which is known to be a major player in adipose lipolysis by binding to the β-adrenergic receptor, was markedly inhibited in KO mice. Supplementation with recombinant human FGF21 to alcohol-exposed FGF21 KO mice resulted in an increase in fat loss in parallel with an increase of circulating norepinephrine concentration. Furthermore, alcohol consumption-induced fatty liver was blunted in the KO mice, indicating an inhibition of fatty acid reverse transport from adipose to the liver in the KO mice. Taken together, our studies demonstrate that FGF21 KO mice are protected from alcohol-induced adipose tissue excess-lipolysis through a mechanism involving systemic catecholamine release. JF - Journal of lipid research AU - Zhao, Cuiqing AU - Liu, Yanlong AU - Xiao, Jian AU - Liu, Liming AU - Chen, Shaoyu AU - Mohammadi, Moosa AU - McClain, Craig J AU - Li, Xiaokun AU - Feng, Wenke AD - College of Basic Medical Sciences, Jilin University, Changchun, China Departments of Medicine University of Louisville School of Medicine, Louisville, KY Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China. ; Departments of Medicine University of Louisville School of Medicine, Louisville, KY Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China. ; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China. ; Departments of Medicine University of Louisville School of Medicine, Louisville, KY Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY. ; Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY. ; Department of Pharmacology, New York University School of Medicine, New York, NY. ; Departments of Medicine University of Louisville School of Medicine, Louisville, KY Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY Robley Rex Veterans Administration Medical Center, Louisville, KY. ; College of Basic Medical Sciences, Jilin University, Changchun, China School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 1481 EP - 1491 VL - 56 IS - 8 KW - Catecholamines KW - 0 KW - Insulin KW - fibroblast growth factor 21 KW - Ethanol KW - 3K9958V90M KW - Fibroblast Growth Factors KW - 62031-54-3 KW - Index Medicus KW - lipolysis and fatty acid metabolism KW - adipose tissue KW - cell signaling KW - liver KW - alcoholic liver disease KW - Animals KW - Epididymis KW - Fatty Liver, Alcoholic -- metabolism KW - Humans KW - Insulin -- metabolism KW - Mice KW - Binge Drinking -- pathology KW - Adipose Tissue, White -- drug effects KW - Gene Knockout Techniques KW - Adipose Tissue, White -- metabolism KW - Binge Drinking -- metabolism KW - Signal Transduction -- drug effects KW - Mice, Inbred C57BL KW - Fatty Liver, Alcoholic -- pathology KW - Gene Expression Regulation -- drug effects KW - Fatty Liver, Alcoholic -- genetics KW - Male KW - Fibroblast Growth Factors -- deficiency KW - Ethanol -- adverse effects KW - Adipose Tissue -- secretion KW - Adipose Tissue -- metabolism KW - Catecholamines -- secretion KW - Adipose Tissue -- drug effects KW - Lipolysis -- drug effects KW - Fibroblast Growth Factors -- pharmacology KW - Fibroblast Growth Factors -- metabolism KW - Fibroblast Growth Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700685795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lipid+research&rft.atitle=FGF21+mediates+alcohol-induced+adipose+tissue+lipolysis+by+activation+of+systemic+release+of+catecholamine+in+mice.&rft.au=Zhao%2C+Cuiqing%3BLiu%2C+Yanlong%3BXiao%2C+Jian%3BLiu%2C+Liming%3BChen%2C+Shaoyu%3BMohammadi%2C+Moosa%3BMcClain%2C+Craig+J%3BLi%2C+Xiaokun%3BFeng%2C+Wenke&rft.aulast=Zhao&rft.aufirst=Cuiqing&rft.date=2015-08-01&rft.volume=56&rft.issue=8&rft.spage=1481&rft.isbn=&rft.btitle=&rft.title=Journal+of+lipid+research&rft.issn=1539-7262&rft_id=info:doi/10.1194%2Fjlr.M058610 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-26 N1 - Date created - 2015-07-30 N1 - Date revised - 2017-02-06 N1 - SuppNotes - Cited By: Science. 1989 Sep 8;245(4922):1118-21 [2570461] J Lipid Res. 1995 Oct;36(10):2164-73 [8576642] J Lipid Res. 1996 Sep;37(9):1842-8 [8895050] Biochem Biophys Res Commun. 1960 Dec;3:635-40 [13715909] Diabetes Metab. 2004 Sep;30(4):294-309 [15525872] Science. 2004 Nov 19;306(5700):1383-6 [15550674] Alcohol. 2004 Aug;34(1):35-8 [15670663] Am J Pathol. 2005 Jun;166(6):1681-90 [15920153] J Clin Invest. 2005 Jun;115(6):1627-35 [15902306] J Biol Chem. 2005 Dec 30;280(52):43109-20 [16243839] Science. 2006 May 5;312(5774):734-7 [16675698] J Biol Chem. 2006 Jun 9;281(23):15837-44 [16595669] J Hepatol. 2006 Nov;45(5):717-24 [16879892] J Biol Chem. 2007 Jan 12;282(2):996-1002 [17114792] Cell Metab. 2007 Jun;5(6):415-25 [17550777] Cell Metab. 2007 Jun;5(6):426-37 [17550778] J Biol Chem. 2007 Sep 14;282(37):26687-95 [17623664] J Biol Chem. 2007 Sep 28;282(39):28465-73 [17686776] Sports Med. 2008;38(5):401-23 [18416594] FEBS Lett. 2008 May 28;582(12):1725-30 [18460341] Cell Metab. 2008 Jul;8(1):77-83 [18585098] Mol Pharmacol. 2008 Aug;74(2):403-12 [18467542] Diabetes. 2009 Jan;58(1):250-9 [18840786] Semin Liver Dis. 2009 May;29(2):178-87 [19387917] Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10853-8 [19541642] Endocrinology. 2009 Oct;150(10):4625-33 [19589869] Endocrinology. 2009 Nov;150(11):4931-40 [19819944] Am J Clin Nutr. 2010 Jan;91(1):254S-257S [19906798] Diabetes. 2010 Jan;59(1):61-70 [19808894] Mol Cell Endocrinol. 2010 Apr 29;318(1-2):34-43 [19747957] Curr Opin Clin Nutr Metab Care. 2010 Jul;13(4):377-81 [20531174] Nat Rev Endocrinol. 2011 Mar;7(3):137-50 [21079616] Nephrol Ther. 2011 Apr;7(2):69-79 [21156355] Am J Pathol. 2011 Dec;179(6):2866-75 [22093263] Cell. 2012 Feb 3;148(3):556-67 [22304921] Am J Pathol. 2012 Mar;180(3):998-1007 [22234172] J Clin Endocrinol Metab. 2012 Apr;97(4):1375-82 [22344195] Horm Metab Res. 2001 Feb;33(2):89-95 [11294499] J Lipid Res. 2012 Nov;53(11):2296-306 [22941773] Cell Metab. 2013 May 7;17(5):779-89 [23663741] Endocrinology. 2013 Sep;154(9):3099-109 [23766126] Br J Pharmacol. 2014 Sep;171(17):4073-86 [24819676] Cell Metab. 2014 Oct 7;20(4):670-7 [25130400] Am J Clin Nutr. 1999 Nov;70(5):928-36 [10539756] Cell. 2000 May 12;101(4):413-24 [10830168] Ann N Y Acad Sci. 1999 Nov 18;892:155-68 [10842661] Diabetes. 2002 Oct;51(10):2929-35 [12351429] J Biol Chem. 2003 Oct 31;278(44):43615-9 [12832420] Biochem Soc Trans. 2003 Dec;31(Pt 6):1120-4 [14641008] Cell. 2004 Jan 23;116(2 Suppl):S89-92, 1 p following S96 [15055592] Mol Pharmacol. 1965 Nov;1(3):280-96 [5842826] Comp Biochem Physiol. 1965 Dec;16(4):367-81 [5881746] Comp Biochem Physiol B. 1971 May 15;39(1):69-82 [5570026] Clin Sci (Lond). 1984 Jun;66(6):643-8 [6723203] Nature. 1986 May 1-7;321(6065):75-9 [3010132] Proc Natl Acad Sci U S A. 1987 Nov;84(22):7920-4 [2825170] J Lipid Res. 1993 Jul;34(7):1057-91 [8371057] Cell Signal. 1994 May;6(4):363-92 [7946963] N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1194/jlr.M058610 ER - TY - JOUR T1 - Assessment of ToxCast Phase II for Mitochondrial Liabilities Using a High-Throughput Respirometric Assay. AN - 1700334475; 25926417 AB - Previous high-throughput screens to identify mitochondrial toxicants used immortalized cell lines and focused on changes in mitochondrial membrane potential, which may not be sufficient and do not identify different types of mitochondrial dysfunction. Primary cultures of renal proximal tubule cells (RPTC) were examined with the Seahorse Extracellular Flux Analyzer to screen 676 compounds (5 μM; 1 h) from the ToxCast Phase II library for mitochondrial toxicants. Of the 676 compounds, 19 were classified as cytotoxicants, 376 were electron transport chain (ETC) inhibitors, and 5 were uncouplers. The remaining 276 compounds were examined after a 5-h exposure to identify slower acting mitochondrial toxicants. This experiment identified 3 cytotoxicants, 110 ETC inhibitors, and 163 compounds with no effect. A subset of the ToxCast Phase II library was also examined in immortalized human renal cells (HK2) to determine differences in susceptibility to mitochondrial toxicity. Of the 131 RPTC ETC inhibitors tested, only 14 were ETC inhibitors in HK2 cells. Of the 5 RPTC uncouplers, 1 compound was an uncoupler in HK2 cells. These results demonstrate that 73% (491/676) of the compounds in the ToxCast Phase II library compounds exhibit RPTC mitochondrial toxicity, overwhelmingly ETC inhibition. In contrast, renal HK2 cells are markedly less sensitive and only identified 6% of the compounds as mitochondrial toxicants. We suggest caution is needed when studying mitochondrial toxicity in immortalized cell lines. This information will provide mechanisms and chemical-based criteria for assessing and predicting mitochondrial liabilities of new drugs, consumer products, and environmental agents. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Wills, Lauren P AU - Beeson, Gyda C AU - Hoover, Douglas B AU - Schnellmann, Rick G AU - Beeson, Craig C AD - *MitoHealth Inc., Charleston, South Carolina. ; *MitoHealth Inc., Charleston, South Carolina, Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 and. ; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 and. ; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 and Ralph H. Johnson Veterans Administration Medical Center, Charleston, South Carolina. ; *MitoHealth Inc., Charleston, South Carolina, Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 and beesonc@musc.edu. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 226 EP - 234 VL - 146 IS - 2 KW - Index Medicus KW - cell culture KW - systems toxicology KW - in vitro and alternatives, kidney KW - safety evaluation KW - Animals KW - Humans KW - Rabbits KW - Female KW - Cell Line KW - Electron Transport -- drug effects KW - High-Throughput Screening Assays KW - Cell Respiration -- drug effects KW - Mitochondria -- drug effects KW - Toxicity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700334475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Assessment+of+ToxCast+Phase+II+for+Mitochondrial+Liabilities+Using+a+High-Throughput+Respirometric+Assay.&rft.au=Wills%2C+Lauren+P%3BBeeson%2C+Gyda+C%3BHoover%2C+Douglas+B%3BSchnellmann%2C+Rick+G%3BBeeson%2C+Craig+C&rft.aulast=Wills&rft.aufirst=Lauren&rft.date=2015-08-01&rft.volume=146&rft.issue=2&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv085 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-31 N1 - Date created - 2015-07-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv085 ER - TY - JOUR T1 - Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation. AN - 1697759688; 25881550 AB - The mechanisms of toxicity during exposure of the airways to chlorinated biomolecules generated during the course of inflammation and to chlorine (Cl2) gas are poorly understood. We hypothesized that lung epithelial cell mitochondria are damaged by Cl2 exposure and activation of autophagy mitigates this injury. To address this, NCI-H441 (human lung adenocarcinoma epithelial) cells were exposed to Cl2 (100 ppm/15 min) and bioenergetics were assessed. One hour after Cl2, cellular bioenergetic function and mitochondrial membrane potential were decreased. These changes were associated with increased MitoSOX signal, and treatment with the mitochondrial redox modulator MitoQ attenuated these bioenergetic defects. At 6h postexposure, there was significant increase in autophagy, which was associated with an improvement of mitochondrial function. Pretreatment of H441 cells with trehalose (an autophagy activator) improved bioenergetic function, whereas 3-methyladenine (an autophagy inhibitor) resulted in increased bioenergetic dysfunction 1h after Cl2 exposure. These data indicate that Cl2 induces bioenergetic dysfunction, and autophagy plays a protective role in vitro. Addition of trehalose (2 vol%) to the drinking water of C57BL/6 mice for 6 weeks, but not 1 week, before Cl2 (400 ppm/30 min) decreased white blood cells in the bronchoalveolar lavage fluid at 6h after Cl2 by 70%. Acute administration of trehalose delivered through inhalation 24 and 1h before the exposure decreased alveolar permeability but not cell infiltration. These data indicate that Cl2 induces bioenergetic dysfunction associated with lung inflammation and suggests that autophagy plays a protective role. Published by Elsevier Inc. JF - Free radical biology & medicine AU - Jurkuvenaite, Asta AU - Benavides, Gloria A AU - Komarova, Svetlana AU - Doran, Stephen F AU - Johnson, Michelle AU - Aggarwal, Saurabh AU - Zhang, Jianhua AU - Darley-Usmar, Victor M AU - Matalon, Sadis AD - Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Pulmonary Injury and Repair Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294,USA; Center for Free Radical Biology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ; Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ; Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Pulmonary Injury and Repair Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Center for Free Radical Biology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294,USA; Center for Free Radical Biology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Veterans Administration Medical Center, Birmingham, AL 35233, USA. ; Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Pulmonary Injury and Repair Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Center for Free Radical Biology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: sadis@uab.edu. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 83 EP - 94 VL - 85 KW - Chlorine KW - 4R7X1O2820 KW - Index Medicus KW - Lung injury KW - Bioenergetics KW - Autophagy KW - Free radicals KW - MitoQ KW - Trehalose KW - 3-Methyladenine KW - Mitochondrial dysfunction KW - Animals KW - Humans KW - Bronchoalveolar Lavage Fluid KW - Mice KW - Energy Metabolism KW - Cell Line KW - Chlorine -- toxicity KW - Mitochondria -- drug effects KW - Inflammation -- chemically induced KW - Lung -- drug effects KW - Mitochondria -- metabolism KW - Up-Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697759688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Upregulation+of+autophagy+decreases+chlorine-induced+mitochondrial+injury+and+lung+inflammation.&rft.au=Jurkuvenaite%2C+Asta%3BBenavides%2C+Gloria+A%3BKomarova%2C+Svetlana%3BDoran%2C+Stephen+F%3BJohnson%2C+Michelle%3BAggarwal%2C+Saurabh%3BZhang%2C+Jianhua%3BDarley-Usmar%2C+Victor+M%3BMatalon%2C+Sadis&rft.aulast=Najavits&rft.aufirst=Lisa&rft.date=2009-07-01&rft.volume=10&rft.issue=3&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Trauma%2C+Violence%2C+%26+Abuse%3A+A+Review+Journal&rft.issn=15248380&rft_id=info:doi/10.1177%2F1524838009334455 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-26 N1 - Date created - 2015-07-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: News Physiol Sci. 2001 Aug;16:185-90 [11479370] Biol Chem. 2002 Mar-Apr;383(3-4):709-13 [12033460] Amino Acids. 2003 Dec;25(3-4):259-74 [14661089] Inhal Toxicol. 2004 Feb;16(2):87-91 [15204781] J Clin Invest. 1982 Sep;70(3):598-607 [6286728] N Engl J Med. 1989 Feb 9;320(6):365-76 [2536474] J Biol Chem. 1992 Nov 25;267(33):23937-41 [1385428] J Clin Invest. 1996 Sep 15;98(6):1283-9 [8823292] J Clin Invest. 1997 May 1;99(9):2075-81 [9151778] Methods Enzymol. 1999;301:151-60 [9919563] J Biol Chem. 2005 Jun 3;280(22):21346-52 [15799967] Arch Biochem Biophys. 2006 Jan 15;445(2):225-34 [16111649] Autophagy. 2005 Jul;1(2):84-91 [16874052] J Biol Chem. 2007 Feb 23;282(8):5641-52 [17182613] Pharmacol Ther. 2007 Sep;115(3):400-9 [17658610] Hepatology. 2008 May;47(5):1725-36 [18311843] PLoS One. 2008;3(10):e3316 [18830406] Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L733-43 [18708632] Am J Emerg Med. 2009 Jan;27(1):1-7 [19041527] Biochem J. 2009 Jan 1;417(1):1-13 [19061483] Biochem J. 2009 Nov 15;424(1):99-107 [19740075] J Biol Chem. 2010 Mar 26;285(13):9716-28 [20106988] Mitochondrion. 2010 Jun;10(4):309-15 [20083234] Proc Am Thorac Soc. 2010 Jul;7(4):278-83 [20601632] Neurobiol Dis. 2010 Sep;39(3):423-38 [20546895] Mov Disord. 2010 Aug 15;25(11):1670-4 [20568096] Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L289-300 [20525917] J Biol Chem. 2010 Nov 5;285(45):34447-59 [20805228] Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L362-9 [21148791] Am J Respir Crit Care Med. 2011 Mar 1;183(5):649-58 [20889906] Hepatology. 2011 Jul;54(1):153-63 [21520201] Am J Respir Cell Mol Biol. 2011 Jul;45(1):88-94 [20855648] Am J Respir Cell Mol Biol. 2011 Aug;45(2):386-92 [21131440] Am J Respir Cell Mol Biol. 2011 Aug;45(2):419-25 [21131444] Am J Respir Cell Mol Biol. 2011 Oct;45(4):867-73 [21441382] Free Radic Biol Med. 2011 Nov 1;51(9):1621-35 [21872656] Biochem J. 2012 Jan 15;441(2):523-40 [22187934] Free Radic Biol Med. 2012 Jan 1;52(1):1-6 [22027063] Am J Respir Cell Mol Biol. 2012 Mar;46(3):342-54 [21997487] Life Sci. 2012 Mar 10;90(11-12):440-5 [22269828] Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1394-409 [22245770] Am J Respir Cell Mol Biol. 2012 May;46(5):599-606 [22162906] J Physiol. 2012 Jul 15;590(14):3305-16 [22570377] Free Radic Biol Med. 2012 Oct 1;53(7):1431-9 [22917977] Chest. 2012 Nov;142(5):1289-99 [23131937] Am J Physiol Lung Cell Mol Physiol. 2013 Jan 1;304(1):L56-69 [23087019] Biol Chem. 2012 Dec;393(12):1485-1512 [23092819] Am J Physiol Lung Cell Mol Physiol. 2013 May 1;304(9):L582-92 [23457187] Am J Physiol Lung Cell Mol Physiol. 2013 Jun 1;304(11):L765-73 [23564508] Free Radic Biol Med. 2013 Oct;63:207-21 [23702245] Free Radic Biol Med. 2013 Dec;65:1215-28 [24056030] Antioxid Redox Signal. 2014 Jan 20;20(3):474-94 [23879400] Nat Protoc. 2014 Feb;9(2):421-38 [24457333] Biochem J. 2010 Nov 15;432(1):9-19 [20825366] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2015.03.039 ER - TY - JOUR T1 - RAN translation at CGG repeats induces ubiquitin proteasome system impairment in models of fragile X-associated tremor ataxia syndrome. AN - 1694962601; 25954027 AB - Fragile X-associated tremor ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a CGG trinucleotide repeat expansion in the 5' UTR of the Fragile X gene, FMR1. FXTAS is thought to arise primarily from an RNA gain-of-function toxicity mechanism. However, recent studies demonstrate that the repeat also elicits production of a toxic polyglycine protein, FMRpolyG, via repeat-associated non-AUG (RAN)-initiated translation. Pathologically, FXTAS is characterized by ubiquitin-positive intranuclear neuronal inclusions, raising the possibility that failure of protein quality control pathways could contribute to disease pathogenesis. To test this hypothesis, we used Drosophila- and cell-based models of CGG-repeat-associated toxicity. In Drosophila, ubiquitin proteasome system (UPS) impairment led to enhancement of CGG-repeat-induced degeneration, whereas overexpression of the chaperone protein HSP70 suppressed this toxicity. In transfected mammalian cells, CGG repeat expression triggered accumulation of a UPS reporter in a length-dependent fashion. To delineate the contributions from CGG repeats as RNA from RAN translation-associated toxicity, we enhanced or impaired the production of FMRpolyG in these models. Driving expression of FMRpolyG enhanced induction of UPS impairment in cell models, while prevention of RAN translation attenuated UPS impairment in cells and suppressed the genetic interaction with UPS manipulation in Drosophila. Taken together, these findings suggest that CGG repeats induce UPS impairment at least in part through activation of RAN translation. Published by Oxford University Press 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US. JF - Human molecular genetics AU - Oh, Seok Yoon AU - He, Fang AU - Krans, Amy AU - Frazer, Michelle AU - Taylor, J Paul AU - Paulson, Henry L AU - Todd, Peter K AD - Department of Neurology, University of Michigan, Ann Arbor, MI, USA. ; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA and. ; Department of Neurology, University of Michigan, Ann Arbor, MI, USA, Neurology, U.S. Department of Veterans Affairs Medical Center, Ann Arbor, MI, USA petertod@umich.edu. Y1 - 2015/08/01/ PY - 2015 DA - 2015 Aug 01 SP - 4317 EP - 4326 VL - 24 IS - 15 KW - Drosophila Proteins KW - 0 KW - FMR1 protein, Drosophila KW - FMR1 protein, human KW - Ubiquitin KW - Fragile X Mental Retardation Protein KW - 139135-51-6 KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Trinucleotide Repeat Expansion -- genetics KW - Animals KW - Proteasome Endopeptidase Complex -- metabolism KW - Humans KW - Drosophila melanogaster KW - Disease Models, Animal KW - Mice KW - Proteasome Endopeptidase Complex -- genetics KW - Animals, Genetically Modified KW - Neurodegenerative Diseases KW - Tremor -- genetics KW - Ubiquitin -- metabolism KW - Ubiquitin -- genetics KW - Tremor -- pathology KW - Fragile X Syndrome -- genetics KW - Ataxia -- genetics KW - Fragile X Mental Retardation Protein -- genetics KW - Drosophila Proteins -- genetics KW - Fragile X Syndrome -- pathology KW - Ataxia -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694962601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=RAN+translation+at+CGG+repeats+induces+ubiquitin+proteasome+system+impairment+in+models+of+fragile+X-associated+tremor+ataxia+syndrome.&rft.au=Oh%2C+Seok+Yoon%3BHe%2C+Fang%3BKrans%2C+Amy%3BFrazer%2C+Michelle%3BTaylor%2C+J+Paul%3BPaulson%2C+Henry+L%3BTodd%2C+Peter+K&rft.aulast=Oh&rft.aufirst=Seok&rft.date=2015-08-01&rft.volume=24&rft.issue=15&rft.spage=4317&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=1460-2083&rft_id=info:doi/10.1093%2Fhmg%2Fddv165 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-17 N1 - Date created - 2015-07-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nat Genet. 1999 Dec;23(4):425-8 [10581028] Am J Hum Genet. 2000 Jan;66(1):6-15 [10631132] Nat Biotechnol. 2000 May;18(5):538-43 [10802622] Nature. 2000 Nov 2;408(6808):101-6 [11081516] Neurology. 2001 Jul 10;57(1):127-30 [11445641] Science. 2002 Feb 1;295(5556):865-8 [11823645] Hum Mol Genet. 2002 May 1;11(9):1107-17 [11978769] Hum Mol Genet. 2002 Nov 1;11(23):2895-904 [12393801] Am J Hum Genet. 2003 Apr;72(4):869-78 [12638084] Hum Mol Genet. 2003 May 1;12(9):985-94 [12700167] Neuron. 2003 Aug 28;39(5):739-47 [12948442] Genetics. 2003 Nov;165(3):1233-42 [14668378] JAMA. 2004 Jan 28;291(4):460-9 [14747503] Hum Mol Genet. 2004 Sep 15;13(18):2011-8 [15254017] Science. 2004 Aug 27;305(5688):1292-5 [15333840] Nature. 1991 Feb 14;349(6310):624-6 [1672039] Science. 1991 May 24;252(5009):1179-81 [2031189] Cell. 1991 May 31;65(5):905-14 [1710175] Science. 1991 Jun 21;252(5013):1711-4 [1675488] Cell. 1991 Aug 23;66(4):817-22 [1878973] Arch Biochem Biophys. 1999 Aug 1;368(1):85-97 [10415115] Trends Cell Biol. 2004 Dec;14(12):703-11 [15564047] Mol Cell. 2005 Apr 1;18(1):37-48 [15808507] FEBS Lett. 2005 May 9;579(12):2702-8 [15862312] Mov Disord. 2007 Oct 31;22(14):2018-30, quiz 2140 [17618523] J Clin Invest. 2008 Jun;118(6):2190-9 [18497889] Hum Mol Genet. 2011 Jun 15;20(12):2308-21 [21441568] Hum Mol Genet. 2011 Dec 15;20(24):4810-21 [21933837] Neurobiol Aging. 2012 May;33(5):1008.e1-15 [22118902] PLoS One. 2012;7(11):e47452 [23139745] Neuron. 2013 Feb 20;77(4):639-46 [23415312] Science. 2013 Mar 15;339(6125):1335-8 [23393093] Cell Rep. 2013 Mar 28;3(3):869-80 [23478018] PLoS One. 2013;8(4):e62572 [23626835] Science. 2014 Sep 5;345(6201):1192-4 [25103406] Acta Neuropathol. 2014 Oct;128(4):485-503 [25120191] Acta Neuropathol. 2014 Oct;128(4):505-24 [25173361] Brain Res. 2014 Oct 10;1584:3-14 [24709120] Neurotherapeutics. 2014 Oct;11(4):721-31 [25005000] Trends Neurosci. 2008 Oct;31(10):521-8 [18778858] Biochim Biophys Acta. 2008 Dec;1782(12):691-9 [18930136] Cell. 2009 Feb 20;136(4):777-93 [19239895] Hum Mol Genet. 2010 Jan 15;19(2):299-312 [19864489] Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5018-23 [20194754] PLoS Genet. 2010;6(12):e1001240 [21170301] Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):260-5 [21173221] Annu Rev Med. 2011;62:411-29 [21090964] Hum Mol Genet. 2011 May 1;20(9):1738-50 [21300695] Ann Neurol. 2010 Mar;67(3):291-300 [20373340] EMBO J. 2010 Apr 7;29(7):1248-61 [20186122] Genetics. 2010 Apr;184(4):927-45 [20065067] Mol Biol Cell. 2010 Jul 1;21(13):2128-37 [20444973] Hum Mol Genet. 2005 Dec 1;14(23):3661-71 [16239243] Brain. 2006 Jan;129(Pt 1):256-71 [16246864] Hum Mol Genet. 2006 Feb 1;15(3):433-42 [16368705] EMBO J. 2006 May 17;25(10):2253-62 [16642034] Hum Mol Genet. 2006 Jul 1;15(13):2138-45 [16723374] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11748-53 [16864772] RNA Biol. 2004 Jul;1(2):103-5 [17179750] J Biol Chem. 2007 Feb 23;282(8):5641-52 [17182613] RNA. 2007 Apr;13(4):555-62 [17283214] Nature. 2007 Jun 14;447(7146):859-63 [17568747] Neuron. 2007 Aug 16;55(4):556-64 [17698009] Neuron. 2007 Aug 16;55(4):565-71 [17698010] Neuron. 2013 May 8;78(3):440-55 [23602499] Acta Neuropathol. 2013 Jul;126(1):1-19 [23793382] Acta Neuropathol. 2013 Dec;126(6):829-44 [24129584] Acta Neuropathol. 2013 Dec;126(6):881-93 [24132570] Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4968-77 [24248382] Curr Opin Cell Biol. 2014 Feb;26:139-46 [24463332] Neurol Clin. 2014 Aug;32(3):705-19, viii [25037086] Neuron. 2014 Sep 3;83(5):1043-50 [25132468] Science. 2014 Sep 5;345(6201):1139-45 [25081482] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/hmg/ddv165 ER - TY - RPRT T1 - SAN FRANCISCO VETERAN AFFAIRS MEDICAL CENTER (SFVAMC) LONG RANGE DEVELOPMENT PLAN. AN - 16384969; 16559 AB - PURPOSE: This EIS evaluates potential environmental impacts resulting from implementation of the Veteran Affairs (VA) Proposed Action. VA's Proposed Action is a Long Range Development Plan (LRDP) that supports the mission of San Francisco Veteran Affairs Medical Center (SFVAMC) to provide for the health care needs of Bay Area and North Coast Veterans by providing for the renovation, expansion, and operation of the SFVAMC Fort Miley Campus within San Francisco County. The purpose of the Proposed Action is to meet the Veterans Health Administration mission of providing comprehensive, high-quality health care services that improve the health and well-being of Veterans and other eligible persons in the San Francisco Bay Area and Northern California. VA's need for the Proposed Action is to address the areas current and future capacity issues brought about by the growing Veteran population, to better serve the ever-changing health care needs of the growing Veteran population, and to provide safe and appropriate facilities for providing health care services and conducting research. This EIS analyzes three action alternatives that would involve implementation of an LRDP. All three action alternatives would include seismic retrofit, demolition, new construction, and operation of VA clinical, research, administrative, and parking structures. Also evaluated is the No Action Alternative, in which VA would continue operation and maintenance of the existing medical center at Fort Miley. Alternative 1 has been identified by VA as the Preferred Alternative. JF - EPA number: 150182, Final EIS, July 10, 2015 Y1 - 2015/07/10/ PY - 2015 DA - 2015 Jul 10 KW - Land Use KW - Air Quality KW - Air Quality Assessments KW - Archaeological Sites KW - Buildings KW - Cultural Resources Assessments KW - Demolition KW - Historic Districts KW - Hospitals KW - Parking KW - Research Facilities KW - Section 105 Statements KW - Traffic Analyses KW - California UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16384969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2015-07-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=SAN+FRANCISCO+VETERAN+AFFAIRS+MEDICAL+CENTER+%28SFVAMC%29+LONG+RANGE+DEVELOPMENT+PLAN.&rft.title=SAN+FRANCISCO+VETERAN+AFFAIRS+MEDICAL+CENTER+%28SFVAMC%29+LONG+RANGE+DEVELOPMENT+PLAN.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Veteran Affairs, Veterans Health Administration, San Francisco, California N1 - Date revised - 2017-01-26 N1 - SuppNotes - Final. Preparation date: July 10, 2015 N1 - Last updated - 2017-01-27 ER - TY - JOUR T1 - Early Life Development in a Multiethnic Sample and the Relation to Late Life Cognition AN - 1761683251; 201600661 AB - Objectives. Poor quality of early life conditions has been associated with poorer late life cognition and increased risk of dementia. Early life physical development can be captured using adult measures of height and head circumference. Availability of resources may be reflected by socioeconomic indicators, such as parental education and family size. We sought to determine the association between early life development and experience and late life semantic memory, episodic memory, and executive functioning abilities, as well as rate of cognitive decline. Method. This study was conducted using the UC Davis Aging Diversity cohort, an ethnically diverse sample of Caucasian, African American, and Hispanic individuals from northern California. We used latent variable modeling to measure growth and childhood socioeconomic environment (SES) and examine their associations with longitudinal cognitive outcomes using mixed effects modeling. Results. Growth was positively related to higher childhood SES. Higher childhood SES was associated with better semantic memory. Both low growth and low SES were associated with increased rate of cognitive decline. Discussion. These findings demonstrate that early life experiences influence the trajectory of cognitive aging. Early life development and experience appears to provide a distal basis upon which additional risk and protective factors interact in the development of dementia. Adapted from the source document. JF - Journals of Gerontology Series B: Psychological Sciences and Social Sciences AU - Melrose, Rebecca J AU - Brewster, Paul AU - Marquine, Maria J AU - MacKay-Brandt, Anna AU - Reed, Bruce AU - Farias, Sarah T AU - Mungas, Dan AD - VA Greater Los Angeles Healthcare System, California rebecca.melrose@va.gov Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 519 EP - 531 PB - Oxford University Press VL - 70 IS - 4 SN - 1079-5014, 1079-5014 KW - Cognition Longitudinal change Minority and diverse populations KW - Socioeconomic Factors KW - Risk KW - Cultural Pluralism KW - Memory KW - Cognitive Development KW - Childhood KW - Socioeconomic Status KW - Cognition KW - Semantics KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761683251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journals+of+Gerontology+Series+B%3A+Psychological+Sciences+and+Social+Sciences&rft.atitle=Early+Life+Development+in+a+Multiethnic+Sample+and+the+Relation+to+Late+Life+Cognition&rft.au=Melrose%2C+Rebecca+J%3BBrewster%2C+Paul%3BMarquine%2C+Maria+J%3BMacKay-Brandt%2C+Anna%3BReed%2C+Bruce%3BFarias%2C+Sarah+T%3BMungas%2C+Dan&rft.aulast=Melrose&rft.aufirst=Rebecca&rft.date=2015-07-01&rft.volume=70&rft.issue=4&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=Journals+of+Gerontology+Series+B%3A+Psychological+Sciences+and+Social+Sciences&rft.issn=10795014&rft_id=info:doi/10.1093%2Fgeronb%2Fgbt126 LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JGBSF3 N1 - SubjectsTermNotLitGenreText - Cognitive Development; Cognition; Socioeconomic Status; Memory; Childhood; Cultural Pluralism; Semantics; Risk; Socioeconomic Factors DO - http://dx.doi.org/10.1093/geronb/gbt126 ER - TY - JOUR T1 - Posttraumatic stress disorder and cancer risk: a nationwide cohort study AN - 1717501636; PQ0001939854 AB - The association between stress and cancer incidence has been studied for more than seven decades. Despite plausible biological mechanisms and evidence from laboratory studies, findings from clinical research are conflicting. The objective of this study was to examine the association between PTSD and various cancer outcomes. This nation-wide cohort study included all Danish-born residents of Denmark from 1995 to 2011. The exposure was PTSD diagnoses (n = 4131). The main outcomes were cancer diagnoses including: (1) all malignant neoplasms; (2) hematologic malignancies; (3) immune-related cancers; (4) smoking- and alcohol-related cancers; (5) cancers at all other sites. Standardized incidence ratios (SIR) were calculated. Null associations were found between PTSD and nearly all cancer diagnoses examined, both overall [SIR for all cancers = 1.0, 95 % confidence interval (CI) = 0.88, 1.2] and in analyses stratified by gender, age, substance abuse history and time since PTSD diagnosis. This study is the most comprehensive examination to date of PTSD as a predictor of many cancer types. Our data show no evidence of an association between PTSD and cancer in this nationwide cohort. JF - European Journal of Epidemiology AU - Gradus, Jaimie L AU - Farkas, Dora Kormendine AU - Svensson, Elisabeth AU - Ehrenstein, Vera AU - Lash, Timothy L AU - Milstein, Arnold AU - Adler, Nancy AU - Soerensen, Henrik Toft AD - National Center for PTSD, VA Boston Healthcare System, 150 S. Huntington Ave (116B-3), Boston, MA, 02130, USA, Jaimie.gradus@va.gov PY - 2015 SP - 563 EP - 568 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 30 IS - 7 SN - 0393-2990, 0393-2990 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Historical account KW - Age KW - Psychology KW - Stress KW - Clinical trials KW - Cancer KW - Health risks KW - Posttraumatic stress disorder KW - Gender KW - Denmark KW - Standards KW - Substance abuse KW - H 4000:Food and Drugs KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717501636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Epidemiology&rft.atitle=Posttraumatic+stress+disorder+and+cancer+risk%3A+a+nationwide+cohort+study&rft.au=Gradus%2C+Jaimie+L%3BFarkas%2C+Dora+Kormendine%3BSvensson%2C+Elisabeth%3BEhrenstein%2C+Vera%3BLash%2C+Timothy+L%3BMilstein%2C+Arnold%3BAdler%2C+Nancy%3BSoerensen%2C+Henrik+Toft&rft.aulast=Gradus&rft.aufirst=Jaimie&rft.date=2015-07-01&rft.volume=30&rft.issue=7&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Epidemiology&rft.issn=03932990&rft_id=info:doi/10.1007%2Fs10654-015-0032-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 25 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Historical account; Health risks; Age; Posttraumatic stress disorder; Psychology; Gender; Stress; Standards; Clinical trials; Substance abuse; Cancer; Denmark DO - http://dx.doi.org/10.1007/s10654-015-0032-7 ER - TY - JOUR T1 - Avibactam and Inhibitor-Resistant SHV beta -Lactamases AN - 1701496792; PQ0001784609 AB - beta -Lactamase enzymes (EC 3.5.2.6) are a significant threat to the continued use of beta -lactam antibiotics to treat infections. A novel non- beta -lactam beta -lactamase inhibitor with activity against many class A and C and some class D beta -lactamase variants, avibactam, is now available in the clinic in partnership with ceftazidime. Here, we explored the activity of avibactam against a variety of characterized isogenic laboratory constructs of beta -lactamase inhibitor-resistant variants of the class A enzyme SHV (M69I/L/V, S130G, K234R, R244S, and N276D). We discovered that the S130G variant of SHV-1 shows the most significant resistance to inhibition by avibactam, based on both microbiological and biochemical characterizations. Using a constant concentration of 4 mg/liter of avibactam as a beta -lactamase inhibitor in combination with ampicillin, the MIC increased from 1 mg/liter for blaSHV-1 to 256 mg/liter for blaSHV S130G expressed in Escherichia coli DH10B. At steady state, the k2/K value of the S130G variant when inactivated by avibactam was 1.3 M-1 s-1, versus 60,300 M-1 s-1 for the SHV-1 beta -lactamase. Under timed inactivation conditions, we found that an approximately 1,700-fold-higher avibactam concentration was required to inhibit SHV S130G than the concentration that inhibited SHV-1. Molecular modeling suggested that the positioning of amino acids in the active site of SHV may result in an alternative pathway of inactivation when complexed with avibactam, compared to the structure of CTX-M-15-avibactam, and that S130 plays a role in the acylation of avibactam as a general acid/base. In addition, S130 may play a role in recyclization. As a result, we advance that the lack of a hydroxyl group at position 130 in the S130G variant of SHV-1 substantially slows carbamylation of the beta -lactamase by avibactam by (i) removing an important proton acceptor and donator in catalysis and (ii) decreasing the number of H bonds. In addition, recyclization is most likely also slow due to the lack of a general base to initiate the process. Considering other inhibitor-resistant mechanisms among class A beta -lactamases, S130 may be the most important amino acid for the inhibition of class A beta -lactamases, perhaps even for the novel diazabicyclooctane class of beta -lactamase inhibitors. JF - Antimicrobial Agents & Chemotherapy AU - Winkler, Marisa L AU - Papp-Wallace, Krisztina M AU - Taracila, Magdalena A AU - Bonomo, Robert A AD - Louis Stokes Veterans Affairs Medical Center, Cleveland, Ohio, USA, robert.bonomo@va.gov. Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 3700 EP - 3709 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 7 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Molecular modelling KW - Amino acids KW - beta -Lactamase KW - Protons KW - Ampicillin KW - Enzymes KW - Acylation KW - Carbamylation KW - Infection KW - Minimum inhibitory concentration KW - Ceftazidime KW - beta -Lactam antibiotics KW - Escherichia coli KW - Catalysis KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701496792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Avibactam+and+Inhibitor-Resistant+SHV+beta+-Lactamases&rft.au=Winkler%2C+Marisa+L%3BPapp-Wallace%2C+Krisztina+M%3BTaracila%2C+Magdalena+A%3BBonomo%2C+Robert+A&rft.aulast=Winkler&rft.aufirst=Marisa&rft.date=2015-07-01&rft.volume=59&rft.issue=7&rft.spage=3700&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.04405-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 34 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Molecular modelling; beta -Lactamase; Amino acids; Protons; Enzymes; Ampicillin; Acylation; Infection; Carbamylation; Minimum inhibitory concentration; Ceftazidime; beta -Lactam antibiotics; Catalysis; Escherichia coli DO - http://dx.doi.org/10.1128/AAC.04405-14 ER - TY - JOUR T1 - Factors Associated with Antibiotic Misuse in Outpatient Treatment for Upper Respiratory Tract Infections AN - 1701496028; PQ0001784595 AB - The Centers for Disease Control and Prevention has promoted the appropriate use of antibiotics since 1995 when it initiated the National Campaign for Appropriate Antibiotic Use in the Community. This study examined upper respiratory tract infections included in the campaign to determine the degree to which antibiotics were appropriately prescribed and subsequent admission rates in a veteran population. This study was a retrospective chart review conducted among outpatients with a diagnosis of a respiratory tract infection, including bronchitis, pharyngitis, sinusitis, or nonspecific upper respiratory tract infection, between January 2009 and December 2011. The study found that 595 (35.8%) patients were treated appropriately, and 1,067 (64.2%) patients received therapy considered inappropriate based on the Get Smart Campaign criteria. Overall the subsequent readmission rate was 1.5%. The majority (77.5%) of patients were prescribed an antibiotic. The most common antibiotics prescribed were azithromycin (39.0%), amoxicillin-clavulanate (13.2%), and moxifloxacin (7.5%). A multivariate regression analysis demonstrated significant predictors of appropriate treatment, including the presence of tonsillar exudates (odds ratio [OR], 0.6; confidence interval [CI], 0.3 to 0.9), fever (OR, 0.6; CI, 0.4 to 0.9), and lymphadenopathy (OR, 0.4; CI, 0.3 to 0.6), while penicillin allergy (OR, 2.9; CI, 1.7 to 4.7) and cough (OR, 1.6; CI, 1.1 to 2.2) were significant predictors for inappropriate treatment. Poor compliance with the Get Smart Campaign was found in outpatients for respiratory infections. Results from this study demonstrate the overprescribing of antibiotics, while providing a focused view of improper prescribing. This article provides evidence that current efforts are insufficient for curtailing inappropriate antibiotic use. JF - Antimicrobial Agents & Chemotherapy AU - Schroeck, Jennifer L AU - Ruh, Christine A AU - Sellick, John A, Jr AU - Ott, Michael C AU - Mattappallil, Arun AU - Mergenhagen, Kari A AD - VA Western New York Healthcare System, Infectious Diseases and Pharmacy Departments, Buffalo, New York, USA, kari.mergenhagen@va.gov. Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 3848 EP - 3852 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 7 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Disease control KW - Cough KW - Antibiotics KW - Pharyngitis KW - Sinusitis KW - Infection KW - Penicillin KW - Fever KW - Respiratory tract diseases KW - Exudates KW - Hypersensitivity KW - Lymphadenopathy KW - Tonsil KW - Moxifloxacin KW - Azithromycin KW - Regression analysis KW - Bronchitis KW - A 01380:Plant Protection, Fungicides & Seed Treatments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701496028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Factors+Associated+with+Antibiotic+Misuse+in+Outpatient+Treatment+for+Upper+Respiratory+Tract+Infections&rft.au=Schroeck%2C+Jennifer+L%3BRuh%2C+Christine+A%3BSellick%2C+John+A%2C+Jr%3BOtt%2C+Michael+C%3BMattappallil%2C+Arun%3BMergenhagen%2C+Kari+A&rft.aulast=Schroeck&rft.aufirst=Jennifer&rft.date=2015-07-01&rft.volume=59&rft.issue=7&rft.spage=3848&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00652-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 20 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Disease control; Cough; Antibiotics; Sinusitis; Pharyngitis; Infection; Penicillin; Fever; Respiratory tract diseases; Lymphadenopathy; Hypersensitivity; Exudates; Tonsil; Moxifloxacin; Azithromycin; Regression analysis; Bronchitis DO - http://dx.doi.org/10.1128/AAC.00652-15 ER - TY - JOUR T1 - Variants of beta -Lactamase KPC-2 That Are Resistant to Inhibition by Avibactam AN - 1701494887; PQ0001784610 AB - KPC-2 is the most prevalent class A carbapenemase in the world. Previously, KPC-2 was shown to hydrolyze the beta -lactamase inhibitors clavulanic acid, sulbactam, and tazobactam. In addition, substitutions at amino acid position R220 in the KPC-2 beta -lactamase increased resistance to clavulanic acid. A novel bridged diazabicyclooctane (DBO) non- beta -lactam beta -lactamase inhibitor, avibactam, was shown to inactivate the KPC-2 beta -lactamase. To better understand the mechanistic basis for inhibition of KPC-2 by avibactam, we tested the potency of ampicillin-avibactam and ceftazidime-avibactam against engineered variants of the KPC-2 beta -lactamase that possessed single amino acid substitutions at important sites (i.e., Ambler positions 69, 130, 234, 220, and 276) that were previously shown to confer inhibitor resistance in TEM and SHV beta -lactamases. To this end, we performed susceptibility testing, biochemical assays, and molecular modeling. Escherichia coli DH10B carrying KPC-2 beta -lactamase variants with the substitutions S130G, K234R, and R220M demonstrated elevated MICs for only the ampicillin-avibactam combinations (e.g., 512, 64, and 32 mg/liter, respectively, versus the MICs for wild-type KPC-2 at 2 to 8 mg/liter). Steady-state kinetics revealed that the S130G variant of KPC-2 resisted inactivation by avibactam; the k2/K ratio was significantly lowered 4 logs for the S130G variant from the ratio for the wild-type enzyme (21,580 M-1 s-1 to 1.2 M-1 s-1). Molecular modeling and molecular dynamics simulations suggested that the mobility of K73 and its ability to activate S70 (i.e., function as a general base) may be impaired in the S130G variant of KPC-2, thereby explaining the slowed acylation. Moreover, we also advance the idea that the protonation of the sulfate nitrogen of avibactam may be slowed in the S130G variant, as S130 is the likely proton donor and another residue, possibly K234, must compensate. Our findings show that residues S130 as well as K234 and R220 contribute significantly to the mechanism of avibactam inactivation of KPC-2. Fortunately, the emergence of S130G, K234R, and R220M variants of KPC in the clinic should not result in failure of ceftazidime-avibactam, as the ceftazidime partner is potent against E. coli DH10B strains possessing all of these variants. JF - Antimicrobial Agents & Chemotherapy AU - Papp-Wallace, Krisztina M AU - Winkler, Marisa L AU - Taracila, Magdalena A AU - Bonomo, Robert A AD - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA, robert.bonomo@va.gov. Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 3710 EP - 3717 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 7 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Molecular modelling KW - Amino acid substitution KW - beta -Lactamase KW - Mobility KW - Protons KW - Enzymes KW - Tazobactam KW - carbapenemase KW - Acylation KW - Minimum inhibitory concentration KW - Sulfate KW - Sulbactam KW - Ceftazidime KW - Kinetics KW - Clavulanic acid KW - Escherichia coli KW - Nitrogen KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701494887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Variants+of+beta+-Lactamase+KPC-2+That+Are+Resistant+to+Inhibition+by+Avibactam&rft.au=Papp-Wallace%2C+Krisztina+M%3BWinkler%2C+Marisa+L%3BTaracila%2C+Magdalena+A%3BBonomo%2C+Robert+A&rft.aulast=Papp-Wallace&rft.aufirst=Krisztina&rft.date=2015-07-01&rft.volume=59&rft.issue=7&rft.spage=3710&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.04406-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 26 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Molecular modelling; beta -Lactamase; Amino acid substitution; Mobility; Protons; Enzymes; carbapenemase; Tazobactam; Acylation; Minimum inhibitory concentration; Sulbactam; Sulfate; Ceftazidime; Clavulanic acid; Kinetics; Nitrogen; Escherichia coli DO - http://dx.doi.org/10.1128/AAC.04406-14 ER - TY - JOUR T1 - Quantitative and Qualitative Antibody Responses to Immunization With the Pneumococcal Polysaccharide Vaccine in HIV-Infected Patients After Initiation of Antiretroviral Treatment: Results From a Randomized Clinical Trial AN - 1722169297; PQ0001911235 AB - Background. Pneumococcal vaccination is recommended for human immunodeficiency virus-infected (HIV+) persons; the best timing for immunization with respect to initiation of antiretroviral therapy (ART) is unknown. Methods. Double-blind, placebo-controlled trial in HIV+ with CD4 super(+) T cells/[mu]L (CD4) > or = 200 randomized to receive the 23-valent pneumococcal polysaccharide vaccine (PPV23) or placebo at enrollment, followed by placebo or PPV23, respectively, 9-12 months later (after > or =6 months of ART). Capsular polysaccharide-specific immunoglobin (Ig) G and IgM levels to serotypes 1, 3, 4, 6B, and 23F, and opsonophagocytic killing activity (OPA) to serotypes 6B and 23F were evaluated 1 month postvaccination. Results. One hundred seven subjects were enrolled, 72 (67.3%) were evaluable (36/group). Both groups had significant increases in pre- to 1-month postvaccination IgG levels, but negligible to IgM, and significant increases in OPA titers to serotype 6B but not to 23F. There were no significant differences between groups in serotype-specific IgM or IgG levels or OPA titers. For the combined groups, there was a significant correlation between serotype-specific IgG and OPA titers to 23F but not to 6B. There was no correlation between CD4, viral load and IgG responses. Conclusions. In HIV+ with CD4 > or = 200, delaying PPV23 until > or =6 months of ART does not improve responses and may lead to missed opportunities for immunization. JF - Journal of Infectious Diseases AU - Rodriguez-Barradas, Maria C AU - Serpa, Jose A AU - Munjal, Iona AU - Mendoza, Daniel AU - Rueda, Adriana M AU - Mushtaq, Mahwish AU - Pirofski, Liise-anne AD - Medical Care Line, Infectious Disease Section, maria.rodriguez-barradas2@va.gov Y1 - 2015/06/01/ PY - 2015 DA - 2015 Jun 01 SP - 1703 EP - 1711 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 211 IS - 11 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - antibody KW - HIV KW - pneumococcal vaccine KW - pneumococcal capsular polysaccharides KW - antiretroviral treatment KW - Serotypes KW - antiretroviral therapy KW - Immunodeficiency KW - Polysaccharides KW - Clinical trials KW - Vaccination KW - Streptococcus pneumoniae KW - CD4 antigen KW - Antiviral agents KW - Human immunodeficiency virus KW - Immunoglobulin G KW - Lymphocytes T KW - Vaccines KW - Immunoglobulin M KW - V 22360:AIDS and HIV KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722169297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Quantitative+and+Qualitative+Antibody+Responses+to+Immunization+With+the+Pneumococcal+Polysaccharide+Vaccine+in+HIV-Infected+Patients+After+Initiation+of+Antiretroviral+Treatment%3A+Results+From+a+Randomized+Clinical+Trial&rft.au=Rodriguez-Barradas%2C+Maria+C%3BSerpa%2C+Jose+A%3BMunjal%2C+Iona%3BMendoza%2C+Daniel%3BRueda%2C+Adriana+M%3BMushtaq%2C+Mahwish%3BPirofski%2C+Liise-anne&rft.aulast=Rodriguez-Barradas&rft.aufirst=Maria&rft.date=2015-06-01&rft.volume=211&rft.issue=11&rft.spage=1703&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiu819 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - CD4 antigen; Serotypes; Antiviral agents; antiretroviral therapy; Lymphocytes T; Immunodeficiency; Immunoglobulin G; Vaccines; Polysaccharides; Vaccination; Clinical trials; Immunoglobulin M; Streptococcus pneumoniae; Human immunodeficiency virus DO - http://dx.doi.org/10.1093/infdis/jiu819 ER - TY - JOUR T1 - Knee Joint Loading During Lineman-Specific Movements in American Football Players AN - 1717497694; PQ0001991824 AB - Linemen are at high risk for knee cartilage injuries and osteoarthritis. High-intensity movements from squatting positions (eg, 3-point stance) may produce high joint loads, increasing the risk for cartilage damage. We hypothesized that knee moments and joint reaction forces during lineman-specific activities would be greater than during walking or jogging. Data were collected using standard motion analysis techniques. Fifteen NCAA linemen (mean + or - SD: height = 1.86 + or -0.07 m, mass= 121.45 + or - 12.78 kg) walked, jogged, and performed 3 unloaded lineman-specific blocking movements from a 3-point stance. External 3-dimen-sional knee moments and joint reaction forces were calculated using inverse dynamics equations. MANOVA with subsequent univariate ANOVA and post hoc Tukey comparisons were used to determine differences in peak kinetic variables and the flexion angles at which they occurred. All peak moments and joint reaction forces were significantly higher during jogging than during all blocking drills (all P 70[degrees] during blocking versus < 44[degrees] in walking or jogging. The magnitude of moments and joint reaction forces when initiating movement from a 3-point stance do not appear to increase risk for cartilage damage, but the high flexion angles at which they occur may increase risk on the posterior femoral condyles. JF - Journal of Applied Biomechanics AU - Lambach, Rebecca L AU - Young, Jay W AU - Flanigan, David C AU - Siston, Robert A AU - Chaudhari, Ajit MW AD - Ohio State University, Rebecca.lambach@va.gov Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 142 EP - 148 PB - Human Kinetics Publishers, P.O. Box 5076 Champaign IL 61825-5076 United States VL - 31 IS - 3 SN - 1065-8483, 1065-8483 KW - Physical Education Index KW - joint moments KW - joint reaction forces KW - motion capture KW - cartilage KW - Running KW - Cartilage KW - Analysis KW - Arthritis KW - Knees KW - Walking KW - Work load KW - Movement KW - Joints KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717497694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Biomechanics&rft.atitle=Knee+Joint+Loading+During+Lineman-Specific+Movements+in+American+Football+Players&rft.au=Lambach%2C+Rebecca+L%3BYoung%2C+Jay+W%3BFlanigan%2C+David+C%3BSiston%2C+Robert+A%3BChaudhari%2C+Ajit+MW&rft.aulast=Lambach&rft.aufirst=Rebecca&rft.date=2015-06-01&rft.volume=31&rft.issue=3&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Biomechanics&rft.issn=10658483&rft_id=info:doi/10.1123%2FJAB.2014-0123 LA - English DB - Physical Education Index N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Arthritis; Analysis; Cartilage; Running; Knees; Walking; Work load; Movement; Joints DO - http://dx.doi.org/10.1123/JAB.2014-0123 ER - TY - JOUR T1 - Chronic pain and comorbid mental health conditions: independent associations of posttraumatic stress disorder and depression with pain, disability, and quality of life AN - 1698867774 AB - Both posttraumatic stress disorder (PTSD) and depression are highly comorbid with chronic pain and have deleterious effects on pain and treatment outcomes, but the nature of the relationships among chronic pain, PTSD, and depression has not been fully elucidated. This study examined 250 Veterans Affairs primary care patients with moderate to severe chronic musculoskeletal pain who participated in a randomized controlled pain treatment trial. Baseline data were analyzed to examine the independent associations of PTSD and major depression with multiple domains of pain, psychological status, quality of life, and disability. PTSD was strongly associated with these variables and in multivariate models, PTSD and major depression each had strong independent associations with these domains. PTSD demonstrated similar relationships as major depression with psychological, quality of life, and disability outcomes and significant but somewhat smaller associations with pain. Because PTSD and major depression have independent negative associations with pain, psychological status, quality of life, and disability, it is important for clinicians to recognize and treat both mental disorders in patients with chronic pain. JF - Journal of Behavioral Medicine AU - Kroenke, Kurt AU - Krebs, Erin E AU - Chumbler, Neale R AU - Wu, Jingwei AU - Yu, Zhangsheng AU - Bair, Matthew J AD - Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development Service CIN 13-416, Center for Health Information and Communication, Indianapolis, IN, USA, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA ; Center for Chronic Disease Outcomes Research, Minneapolis VA Health Care System, Minneapolis, MN, USA, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA ; Department of Health Policy and Management, College of Public Health, University of Georgia, Athens, GA, USA ; Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA ; Outcalt, Samantha D; Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development Service CIN 13-416, Center for Health Information and Communication, Indianapolis, IN, USA; Roudebush VA Medical Center, 1481 W. 10th St. (11H), Indianapolis, IN, 46202, USA Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 535 EP - 543 CY - New York PB - Springer Science & Business Media VL - 38 IS - 3 SN - 0160-7715 KW - Psychology KW - Associations KW - Chronic posttraumatic stress disorder KW - Patient care KW - Primary health care KW - Psychiatric disorders KW - Psychological status KW - Quality of life KW - Veterans KW - Chronic pain KW - Clinical outcomes KW - Comorbidity KW - Depression KW - Disability KW - Life stress KW - Mental health KW - Musculoskeletal pain KW - Pain UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698867774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Medicine&rft.atitle=Chronic+pain+and+comorbid+mental+health+conditions%3A+independent+associations+of+posttraumatic+stress+disorder+and+depression+with+pain%2C+disability%2C+and+quality+of+life&rft.au=Outcalt%2C+Samantha+D%3BKroenke%2C+Kurt%3BKrebs%2C+Erin+E%3BChumbler%2C+Neale+R%3BWu%2C+Jingwei%3BYu%2C+Zhangsheng%3BBair%2C+Matthew+J&rft.aulast=Outcalt&rft.aufirst=Samantha&rft.date=2015-06-01&rft.volume=38&rft.issue=3&rft.spage=535&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Medicine&rft.issn=01607715&rft_id=info:doi/10.1007%2Fs10865-015-9628-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-07-07 N1 - Last updated - 2016-05-12 DO - http://dx.doi.org/10.1007/s10865-015-9628-3 ER - TY - CONF T1 - Medications and the Culture of Safety : Conference Title: At the Precipice of Quality Health Care: The Role of the Toxicologist in Enhancing Patient and Medication Safety Venue ACMT Pre-Meeting Symposium, 2014 North American Congress of Clinical Toxicology, New Orleans, LA. AN - 1689844231; 25804671 AB - Medication mishaps are a common cause of morbidity and mortality both within and outside of hospitals. While the use of a variety of technologies and techniques have promised to improve these statistics, instead of eliminating errors, new ones have appeared as quickly as old ones have been improved. To truly improve safety across the entire enterprise, we must ensure that we create a culture that is willing to accept that errors occur in normal course of operation to the best of people. Focus must not be on punishment and shame, but rather building a fault tolerant system that maintains safety of both staff and patients. JF - Journal of medical toxicology : official journal of the American College of Medical Toxicology AU - Hemphill, Robin R Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 253 EP - 256 VL - 11 IS - 2 KW - Index Medicus KW - Humans KW - Quality of Health Care -- trends KW - Organizational Culture KW - Medical Errors -- prevention & control KW - Toxicology KW - Leadership KW - Patient Safety KW - Culture KW - Drug-Related Side Effects and Adverse Reactions -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1689844231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Journal+of+medical+toxicology+%3A+official+journal+of+the+American+College+of+Medical+Toxicology&rft.atitle=Medications+and+the+Culture+of+Safety+%3A+Conference+Title%3A+At+the+Precipice+of+Quality+Health+Care%3A+The+Role+of+the+Toxicologist+in+Enhancing+Patient+and+Medication+Safety+Venue+ACMT+Pre-Meeting+Symposium%2C+2014+North+American+Congress+of+Clinical+Toxicology%2C+New+Orleans%2C+LA.&rft.au=Hemphill%2C+Robin+R&rft.aulast=Hemphill&rft.aufirst=Robin&rft.date=2015-06-01&rft.volume=11&rft.issue=2&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Journal+of+medical+toxicology+%3A+official+journal+of+the+American+College+of+Medical+Toxicology&rft.issn=1937-6995&rft_id=info:doi/10.1007%2Fs13181-015-0474-z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-22 N1 - Date created - 2015-06-17 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Health Serv Res. 2006 Aug;41(4 Pt 2):1690-709 [16898986] J Am Med Inform Assoc. 2013 May 1;20(3):470-6 [23425440] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s13181-015-0474-z ER - TY - JOUR T1 - Gray-matter volume, midbrain dopamine D2/D3 receptors and drug craving in methamphetamine users. AN - 1682891487; 25896164 AB - Dysfunction of the mesocorticolimbic system has a critical role in clinical features of addiction. Despite evidence suggesting that midbrain dopamine receptors influence amphetamine-induced dopamine release and that dopamine is involved in methamphetamine-induced neurotoxicity, associations between dopamine receptors and gray-matter volume have been unexplored in methamphetamine users. Here we used magnetic resonance imaging and [(18)F]fallypride positron emission tomography, respectively, to measure gray-matter volume (in 58 methamphetamine users) and dopamine D2/D3 receptor availability (binding potential relative to nondisplaceable uptake of the radiotracer, BPnd) (in 31 methamphetamine users and 37 control participants). Relationships between these measures and self-reported drug craving were examined. Although no difference in midbrain D2/D3 BPnd was detected between methamphetamine and control groups, midbrain D2/D3 BPnd was positively correlated with gray-matter volume in the striatum, prefrontal cortex, insula, hippocampus and temporal cortex in methamphetamine users, but not in control participants (group-by-midbrain D2/D3 BPnd interaction, P<0.05 corrected for multiple comparisons). Craving for methamphetamine was negatively associated with gray-matter volume in the insula, prefrontal cortex, amygdala, temporal cortex, occipital cortex, cerebellum and thalamus (P<0.05 corrected for multiple comparisons). A relationship between midbrain D2/D3 BPnd and methamphetamine craving was not detected. Lower midbrain D2/D3 BPnd may increase vulnerability to deficits in gray-matter volume in mesocorticolimbic circuitry in methamphetamine users, possibly reflecting greater dopamine-induced toxicity. Identifying factors that influence prefrontal and limbic volume, such as midbrain BPnd, may be important for understanding the basis of drug craving, a key factor in the maintenance of substance-use disorders. JF - Molecular psychiatry AU - Morales, A M AU - Kohno, M AU - Robertson, C L AU - Dean, A C AU - Mandelkern, M A AU - London, E D AD - Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA. ; 1] Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA [2] Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA. ; 1] Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA [2] Departments of Brain Research Institute, University of California, Los Angeles, CA, USA. ; 1] Department of Physics, University of California Irvine, Irvine, CA, USA [2] Veterans Administration of Greater Los Angeles Health System, Los Angeles, CA, USA. ; 1] Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA [2] Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA [3] Departments of Brain Research Institute, University of California, Los Angeles, CA, USA [4] Veterans Administration of Greater Los Angeles Health System, Los Angeles, CA, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 764 EP - 771 VL - 20 IS - 6 KW - Benzamides KW - 0 KW - Dopamine Antagonists KW - Receptors, Dopamine D2 KW - fallypride KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Magnetic Resonance Imaging KW - Regression Analysis KW - Fluorodeoxyglucose F18 -- pharmacokinetics KW - Positron-Emission Tomography KW - Protein Binding -- drug effects KW - Humans KW - Benzamides -- pharmacokinetics KW - Dopamine Antagonists -- pharmacokinetics KW - Time Factors KW - Image Processing, Computer-Assisted KW - Male KW - Female KW - Substance-Related Disorders -- physiopathology KW - Mesencephalon -- drug effects KW - Gray Matter -- drug effects KW - Mesencephalon -- pathology KW - Substance-Related Disorders -- pathology KW - Methamphetamine -- pharmacology KW - Mesencephalon -- diagnostic imaging KW - Gray Matter -- pathology KW - Substance-Related Disorders -- psychology KW - Receptors, Dopamine D2 -- metabolism KW - Drug-Seeking Behavior -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1682891487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+psychiatry&rft.atitle=Gray-matter+volume%2C+midbrain+dopamine+D2%2FD3+receptors+and+drug+craving+in+methamphetamine+users.&rft.au=Morales%2C+A+M%3BKohno%2C+M%3BRobertson%2C+C+L%3BDean%2C+A+C%3BMandelkern%2C+M+A%3BLondon%2C+E+D&rft.aulast=Morales&rft.aufirst=A&rft.date=2015-06-01&rft.volume=20&rft.issue=6&rft.spage=764&rft.isbn=&rft.btitle=&rft.title=Molecular+psychiatry&rft.issn=1476-5578&rft_id=info:doi/10.1038%2Fmp.2015.47 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-09 N1 - Date created - 2015-05-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nat Med. 1996 Jun;2(6):699-703 [8640565] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):12040-5 [8876259] IEEE Trans Med Imaging. 1997 Apr;16(2):176-86 [9101327] Neuron. 1997 Sep;19(3):591-611 [9331351] Nucl Med Biol. 1999 Jul;26(5):519-27 [10473190] Synapse. 2005 Nov;58(2):110-21 [16088948] IEEE Trans Med Imaging. 2005 Dec;24(12):1548-65 [16350916] Trends Neurosci. 2006 Mar;29(3):167-74 [16443286] J Neurosci. 2006 Jun 14;26(24):6583-8 [16775146] AAPS J. 2006;8(2):E413-8 [16808044] Crit Rev Neurobiol. 2005;17(2):87-117 [16808729] Neuropsychopharmacology. 2006 Dec;31(12):2716-27 [16971900] Med Image Comput Comput Assist Interv. 2006;9(Pt 2):33-40 [17354753] Neuroimage. 2007 Oct 15;38(1):95-113 [17761438] Neuroimage. 2008 Feb 1;39(3):1266-73 [18024160] Magn Reson Med. 2008 Apr;59(4):866-73 [18383286] Am J Psychiatry. 2008 Sep;165(9):1179-84 [18593776] J Neurosci. 2008 Dec 31;28(53):14372-8 [19118170] Neuroimage. 2009 Mar;45(1 Suppl):S173-86 [19059349] Biol Psychiatry. 2009 Apr 15;65(8):706-9 [19136097] Pharmacol Biochem Behav. 2009 Sep;93(3):343-8 [19490925] Int Rev Neurobiol. 2009;88:101-19 [19897076] J Neurosci. 2009 Nov 25;29(47):14734-40 [19940168] Neuropsychopharmacology. 2010 Jan;35(1):217-38 [19710631] Neuroimage. 2010 May 1;50(4):1392-401 [20096794] Neuroimage. 2010 May 15;51(1):53-62 [20149883] Science. 2010 Jul 30;329(5991):532 [20671181] Addiction. 2010 Oct;105(10):1809-18 [20840201] Neuropsychopharmacology. 2011 Feb;36(3):569-79 [20980989] J Neurosci. 2011 Mar 30;31(13):4805-10 [21451018] Addiction. 2011 Aug;106(8):1474-83 [21438934] Nat Neurosci. 2011 Aug;14(8):1033-8 [21743470] Neuroimage. 2000 Jun;11(6 Pt 1):805-21 [10860804] Alcohol Res Health. 1999;23(3):187-96 [10890814] Am J Psychiatry. 2000 Nov;157(11):1789-98 [11058476] Addiction. 2001 Jan;96(1):33-46 [11177518] Am J Psychiatry. 2001 Mar;158(3):377-82 [11229977] Schizophr Res. 2011 Nov;132(2-3):183-9 [21784619] Psychiatry Res. 2011 Dec 30;194(3):287-95 [22047731] J Neurosci. 2012 Jan 25;32(4):1353-9 [22279219] J Neurosci. 2012 Apr 25;32(17):5843-52 [22539846] Pharmacol Biochem Behav. 2012 Jul;102(1):124-32 [22507913] Mol Psychiatry. 2012 Sep;17(9):918-25 [21747399] Drug Alcohol Depend. 2012 Oct 1;125(3):230-8 [22445480] J Intern Med. 2013 May;273(5):437-53 [23600399] Psychopharmacology (Berl). 2013 Oct;229(3):527-38 [23748383] Neuropsychopharmacology. 2014 Jul;39(8):1833-42 [24513972] Neuropsychopharmacology. 2014 Jul;39(8):1816-22 [24584328] Am J Psychiatry. 2001 Dec;158(12):2015-21 [11729018] Neuropsychopharmacology. 2002 Mar;26(3):376-86 [11850152] Synapse. 2002 Dec 1;46(3):170-88 [12325044] Neuroimage. 1996 Dec;4(3 Pt 1):153-8 [9345505] Am J Psychiatry. 1998 Jan;155(1):124-6 [9433350] Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7731-6 [9636219] Neuropsychopharmacology. 1999 Jan;20(1):60-80 [9885786] Am J Psychiatry. 1999 Jan;156(1):11-8 [9892292] Am J Psychiatry. 1999 Jan;156(1):19-26 [9892293] JAMA Psychiatry. 2014 Jul 1;71(7):812-20 [24850532] J Cereb Blood Flow Metab. 2002 Dec;22(12):1440-52 [12468889] J Neurosci. 2003 Apr 15;23(8):3531-7 [12716962] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11035-40 [12958210] Drug Alcohol Depend. 2004 Feb 7;73(2):121-32 [14725951] J Neurosci. 2004 Feb 18;24(7):1551-60 [14973230] J Neurosci. 2004 Jun 30;24(26):6028-36 [15229250] Life Sci. 1979 Oct 15;25(16):1373-8 [42834] Ann N Y Acad Sci. 1990;604:323-43 [2171398] J Comput Assist Tomogr. 1995 Jul-Aug;19(4):615-23 [7622696] Nucl Med Biol. 1995 Apr;22(3):283-96 [7627142] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/mp.2015.47 ER - TY - JOUR T1 - Safety of biologic and nonbiologic disease-modifying antirheumatic drug therapy in veterans with rheumatoid arthritis and hepatitis B virus infection: a retrospective cohort study. AN - 1683574764; 26001631 AB - We evaluated the safety of current treatment regimens for patients with RA and HBV in a large US cohort. We identified biologic and nonbiologic treatment episodes of RA patients using 1997 to 2011 national data from the US Veterans Health Administration. Eligible episodes had evidence of HBV infection (HBV surface antigen, HBV core antibody, HBV e-antibody and/or HBV DNA) and had a baseline alanine aminotransferase (ALT) 100 IU/mL. Results were reported as the cumulative incidence of treatment episodes achieving hepatotoxicity at 3, 6 and 12 months post biologic exposure. Five hundred sixty-six unique RA patients with HBV contributed 959 treatment episodes. Mean age was 62.1 ± 10.3 years; 91.8% were male. Hepatotoxicity was uncommon, with 26 events identified among 959 episodes (2.7%) within 12 months. Hepatotoxicity was comparable between biologic and nonbiologic DMARDs (2.6% vs. 2.8%, P = 0.87). The median time between HBV screening and starting a new RA drug was 504 days (IQR 144, 1,163). Follow-up HBV testing occurred among 14 hepatotoxicity episodes (53.8%) at a median of 202 days (IQR 82, 716) from the date of ALT elevation. A total of 146 (15.2%) treatment episodes received at least one test for HBV DNA at any point in the observation period. Among US veterans with RA and HBV the risk of hepatotoxicity is low (2.7%), and comparable between biologic and nonbiologic DMARDS (2.8% vs. 2.6%, P = 0.87). HBV testing associated with DMARD initiation or hepatotoxicity was infrequent. JF - Arthritis research & therapy AU - Burton, Mary Jane AU - Curtis, Jeffrey R AU - Yang, Shuo AU - Chen, Lang AU - Singh, Jasvinder A AU - Mikuls, Ted R AU - Winthrop, Kevin L AU - Baddley, John W AD - G.V. Sonny Montgomery VA Medical Center, 1500 E Woodrow Wilson Avenue, Jackson, MS, 39216, USA. Mary.burton2@va.gov. ; Birmingham VAMC, 700 19th Street S, Birmingham, AL, 35233, USA. jcurtis@uab.edu. ; Birmingham VAMC, 700 19th Street S, Birmingham, AL, 35233, USA. shouyang@uab.edu. ; Birmingham VAMC, 700 19th Street S, Birmingham, AL, 35233, USA. langchen@uab.edu. ; Birmingham VAMC, 700 19th Street S, Birmingham, AL, 35233, USA. jassingh@uab.edu. ; Omaha VAMC; UNMC, 4101 Woolworth Avenue, Omaha, NE, 68105, USA. tmikuls@unmc.edu. ; Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA. winthrop@ohsu.edu. ; Birmingham VAMC, 700 19th Street S, Birmingham, AL, 35233, USA. jbaddley@uab.edu. Y1 - 2015/05/22/ PY - 2015 DA - 2015 May 22 SP - 136 VL - 17 KW - Antirheumatic Agents KW - 0 KW - Index Medicus KW - Veterans KW - Humans KW - Cohort Studies KW - Retrospective Studies KW - Incidence KW - Aged KW - Middle Aged KW - Male KW - Female KW - Arthritis, Rheumatoid -- drug therapy KW - Hepatitis B -- complications KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- epidemiology KW - Antirheumatic Agents -- adverse effects KW - Arthritis, Rheumatoid -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683574764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=VA+intensive+mental+health+case+management+in+urban+and+rural+areas%3A+veteran+characteristics+and+service+delivery.&rft.au=Mohamed%2C+Somaia%3BNeale%2C+Michael%3BRosenheck%2C+Robert+A&rft.aulast=Mohamed&rft.aufirst=Somaia&rft.date=2009-07-01&rft.volume=60&rft.issue=7&rft.spage=914&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=1557-9700&rft_id=info:doi/10.1176%2Fappi.ps.60.7.914 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-25 N1 - Date created - 2015-05-24 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: AIDS. 2000 Dec 22;14(18):2895-902 [11153671] Ann Rheum Dis. 2011 Oct;70(10):1719-25 [21719446] Ann Rheum Dis. 2011 Oct;70(10):1701-3 [21893581] Hepatology. 2012 Feb;55(2):447-54 [21987480] Arthritis Care Res (Hoboken). 2012 May;64(5):625-39 [22473917] Arthritis Care Res (Hoboken). 2012 Aug;64(8):1265-8 [22392695] Clin Rheumatol. 2012 Aug;31(8):1169-75 [22544263] Clin Mol Hepatol. 2012 Jun;18(2):225-8 [22893874] Ann Rheum Dis. 2013 Feb;72(2):308-10 [22930597] Arthritis Rheum. 2001 Feb;44(2):339-42 [11229464] Gastroenterology. 1987 Jun;92(6):1839-43 [3569757] Hepatology. 1998 May;27(5):1213-9 [9581673] Pharmacoepidemiol Drug Saf. 2006 Apr;15(4):241-3 [16552790] Ann Rheum Dis. 2006 Aug;65(8):983-9 [16627542] Arthritis Rheum. 2008 Jun 15;59(6):762-84 [18512708] MMWR Recomm Rep. 2008 Sep 19;57(RR-8):1-20 [18802412] Hepatology. 2009 May;49(5 Suppl):S156-65 [19399803] Ann Rheum Dis. 2009 Jul;68(7):1086-93 [19033291] Hepatology. 2009 Sep;50(3):661-2 [19714720] Arthritis Res Ther. 2009;11(6):R179 [19941642] Arthritis Care Res (Hoboken). 2013 Sep;65(9):1504-14 [23436730] Int J Rheum Dis. 2013 Oct;16(5):527-31 [24164839] Clin Rheumatol. 2014 Apr;33(4):577-86 [24343455] Eur J Intern Med. 2014 Jun;25(5):482-4 [24495663] J Rheumatol. 2010 Feb;37(2):346-50 [20008922] Clin Exp Rheumatol. 2009 Nov-Dec;27(6):1017-25 [20149325] Arthritis Care Res (Hoboken). 2010 May;62(5):704-11 [20461789] Arthritis Care Res (Hoboken). 2010 Jun;62(6):749-54 [20535784] Ann Rheum Dis. 2010 Jul;69(7):1352-5 [20472596] Clin Rheumatol. 2010 Sep;29(9):1021-9 [20556450] Mod Rheumatol. 2011 Feb;21(1):16-23 [20668905] Nat Rev Rheumatol. 2011 Mar;7(3):139-50 [21263458] Mod Rheumatol. 2013 Jul;23(4):694-704 [22802011] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s13075-015-0628-z ER - TY - CPAPER T1 - Listening Effort and the Division of Auditory Processing Resources T2 - 169th Meeting of the Acoustical Society of America AN - 1669822995; 6341386 JF - 169th Meeting of the Acoustical Society of America AU - Gallun, Frederick Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Information processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Listening+Effort+and+the+Division+of+Auditory+Processing+Resources&rft.au=Gallun%2C+Frederick&rft.aulast=Gallun&rft.aufirst=Frederick&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Effects of Hospital Noise on Speech Intelligibility T2 - 169th Meeting of the Acoustical Society of America AN - 1669822542; 6341499 JF - 169th Meeting of the Acoustical Society of America AU - Gallun, Frederick Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - speech KW - Noise KW - Noise levels KW - Hospitals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Effects+of+Hospital+Noise+on+Speech+Intelligibility&rft.au=Gallun%2C+Frederick&rft.aulast=Gallun&rft.aufirst=Frederick&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - Using a Spiritual Distress Scale to Assess Suicide Risk in Veterans: An Exploratory Study AN - 1683501085 AB - This exploratory study (1) examined the ability of a spiritual distress scale used by chaplains to identify Veterans with certain suicide risk factors and (2) provided an initial assessment of the reliability and validity of this scale to screen for Veterans at increased risk of suicide based on the presence of these risk factors. The scale consisted of five questions examining the presence or absence of guilt, sadness or grief, anger or resentment, despair or hopelessness, and feeling that life has no meaning or purpose. The scale was analyzed using Chronbach’s α-coefficient, factor analysis, Student’s t-tests, and logistic regression. Cut-off values were determined using the maximum Youden statistic. The five questions had a high level of internal consistency (α =0.88). Factor analysis suggested the presence of a common underlying factor, with correlations ranging from 0.42 to 0.78. Those identified with a suicide risk factor had significantly higher mean composite scores on this scale. Further, scores were significantly associated with increased odds of being identified with a suicide risk factor. A score ≥10 may be best suited for differentiating between individuals with and without certain suicide risk factors. This scale shows promise for identifying Veterans who may be at increased risk of suicide. JF - Pastoral Psychology AU - Kopacz, Marek S AU - Hoffmire, Claire A AU - Morley, Sybil W AU - Vance, C Garland AD - U.S. Department of Veterans Affairs, VISN 2 Center of Excellence for Suicide Prevention, 400 Fort Hill Avenue, Canandaigua, NY, 14424, USA marek.kopacz@va.gov marek.kopacz@va.gov marek.kopacz@va.gov; U.S. Department of Veterans Affairs, Charles George VA Medical Center, 1100 Tunnel Road, Asheville, NC, 28805, USA ; U.S. Department of Veterans Affairs, VISN 2 Center of Excellence for Suicide Prevention, 400 Fort Hill Avenue, Canandaigua, NY, 14424, USA Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 381 EP - 390 CY - New York PB - Springer Science & Business Media VL - 64 IS - 3 SN - 0031-2789 KW - Religions And Theology KW - Anger KW - Psychological distress KW - Reliability KW - Resentment KW - Risk assessment KW - Risk factors KW - Sadness KW - Suicide KW - Veterans KW - Chaplains KW - Clinical assessment KW - Despair KW - Factor analysis KW - Grief KW - Guilt KW - Hopelessness KW - Life meaning KW - Meaning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683501085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pastoral+Psychology&rft.atitle=Using+a+Spiritual+Distress+Scale+to+Assess+Suicide+Risk+in+Veterans%3A+An+Exploratory+Study&rft.au=Kopacz%2C+Marek+S%3BHoffmire%2C+Claire+A%3BMorley%2C+Sybil+W%3BVance%2C+C+Garland&rft.aulast=Kopacz&rft.aufirst=Marek&rft.date=2015-05-01&rft.volume=64&rft.issue=3&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Pastoral+Psychology&rft.issn=00312789&rft_id=info:doi/10.1007%2Fs11089-014-0633-1 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-04-15 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1007/s11089-014-0633-1 ER - TY - JOUR T1 - Urinary ATP Synthase Subunit β Is a Novel Biomarker of Renal Mitochondrial Dysfunction in Acute Kidney Injury. AN - 1676339963; 25666834 AB - Although the importance of mitochondrial dysfunction in acute kidney injury (AKI) has been documented, noninvasive early biomarkers of mitochondrial damage are needed. We examined urinary ATP synthase subunit β (ATPSβ) as a biomarker of renal mitochondrial dysfunction during AKI. Mice underwent sham surgery or varying degrees (5, 10, or 15 min ischemia) of ischemia/reperfusion (I/R)-induced AKI. Serum creatinine, BUN, and neutrophil gelatinase-associated lipocalin were elevated only in the 15 min I/R group at 24 h. Immunoblot analysis of urinary ATPSβ revealed two bands (full length ∼52 kDa and cleaved ∼25 kDa), both confirmed as ATPSβ by LC-MS/MS, that increased at 24 h in 10- and 15-min I/R groups. These changes were associated with mitochondrial dysfunction evidenced by reduced renal cortical expression of mitochondrial proteins, ATPSβ and COX1, proximal tubular oxygen consumption, and ATP. Furthermore, in the 15-min I/R group, urinary ATPSβ was elevated until 72 h before returning to baseline 144 h after reperfusion with recovery of renal function. Evaluation of urinary ATPSβ in a nonalcoholic steatohepatitis model of liver injury only revealed cleaved ATPSβ, suggesting specificity of full-length ATPSβ for renal injury. Immunoblot analyses of patient urine samples collected 36 h after cardiac surgery revealed increased urinary ATPSβ levels in patients with postcardiac surgery-induced AKI. LC-MS/MS urinalysis in human subjects with AKI confirmed increased ATPSβ. These translational studies provide evidence that ATPSβ may be a novel and sensitive urinary biomarker of renal mitochondrial dysfunction and could serve as valuable tool for the testing of potential therapies for AKI and chemical-induced nephrotoxicity. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Whitaker, Ryan M AU - Korrapati, Midhun C AU - Stallons, Lindsey J AU - Jesinkey, Sean R AU - Arthur, John M AU - Beeson, Craig C AU - Zhong, Zhi AU - Schnellmann, Rick G AD - *Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina 29425 and Ralph H. Johnson Veterans Administration Medical Center, Charleston, South Carolina 29425 schnell@musc.edu. ; *Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina 29425 and Ralph H. Johnson Veterans Administration Medical Center, Charleston, South Carolina 29425. ; *Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina 29425 and Ralph H. Johnson Veterans Administration Medical Center, Charleston, South Carolina 29425 *Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina 29425 and Ralph H. Johnson Veterans Administration Medical Center, Charleston, South Carolina 29425. ; *Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina 29425 and Ralph H. Johnson Veterans Administration Medical Center, Charleston, South Carolina 29425 *Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina 29425 and Ralph H. Johnson Veterans Administration Medical Center, Charleston, South Carolina 29425 schnell@musc.edu. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 108 EP - 117 VL - 145 IS - 1 KW - Biomarkers KW - 0 KW - F1F0-ATP synthase KW - EC 3.6.1.- KW - Mitochondrial Proton-Translocating ATPases KW - EC 3.6.3.- KW - Index Medicus KW - mitochondria KW - acute kidney injury KW - biomarker KW - ischemia-reperfusion KW - ATP synthase β KW - Animals KW - Humans KW - Mice, Inbred C57BL KW - Aged KW - Male KW - Female KW - Mitochondria -- physiology KW - Acute Kidney Injury -- physiopathology KW - Biomarkers -- urine KW - Acute Kidney Injury -- enzymology KW - Mitochondrial Proton-Translocating ATPases -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676339963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Urinary+ATP+Synthase+Subunit+%CE%B2+Is+a+Novel+Biomarker+of+Renal+Mitochondrial+Dysfunction+in+Acute+Kidney+Injury.&rft.au=Whitaker%2C+Ryan+M%3BKorrapati%2C+Midhun+C%3BStallons%2C+Lindsey+J%3BJesinkey%2C+Sean+R%3BArthur%2C+John+M%3BBeeson%2C+Craig+C%3BZhong%2C+Zhi%3BSchnellmann%2C+Rick+G&rft.aulast=Whitaker&rft.aufirst=Ryan&rft.date=2015-05-01&rft.volume=145&rft.issue=1&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv038 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-16 N1 - Date created - 2015-04-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nat Rev Neurol. 2013 Aug;9(8):474-81 [23817350] J Am Soc Nephrol. 2014 Jun;25(6):1157-62 [24511124] J Pharmacol Exp Ther. 2013 Dec;347(3):626-34 [24042162] Toxicol Appl Pharmacol. 2013 Dec 1;273(2):345-54 [24096033] Toxicol Lett. 2014 Jan 30;224(3):326-32 [24275386] Am J Physiol Renal Physiol. 2014 Feb 15;306(4):F367-78 [24305473] Clin J Am Soc Nephrol. 2014 Mar;9(3):435-6 [24526743] Nat Rev Nephrol. 2014 Apr;10(4):193-207 [24445744] J Am Soc Nephrol. 2003 Aug;14(8):2199-210 [12874476] Kidney Int. 1998 Jan;53(1):100-11 [9453005] Am J Physiol Renal Physiol. 2005 Jun;288(6):F1092-102 [15625081] Mol Cell Proteomics. 2006 Feb;5(2):313-23 [16244361] Nephron Physiol. 2007;105(1):p1-10 [17095876] J Clin Invest. 2009 May;119(5):1275-85 [19349686] Oxid Med Cell Longev. 2008 Oct-Dec;1(1):33-8 [19794906] Contrib Nephrol. 2010;165:9-17 [20427950] Anal Biochem. 2010 Sep 1;404(1):75-81 [20465991] Am J Physiol Renal Physiol. 2012 Apr 1;302(7):F853-64 [22160772] Anal Chim Acta. 2012 May 21;727:8-12 [22541816] Expert Opin Drug Metab Toxicol. 2012 Jun;8(6):655-64 [22475359] J Pharmacol Exp Ther. 2012 Oct;343(1):34-43 [22736507] Clin J Am Soc Nephrol. 2013 Feb;8(2):184-93 [23143504] Transplantation. 2002 Feb 27;73(4):493-9 [11889418] PLoS One. 2013;8(9):e73655 [24040012] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv038 ER - TY - JOUR T1 - Bleeding risk, physical functioning and non-use of anticoagulation among patients with stroke and atrial fibrillation AN - 1811909380; PQ0003424252 AB - Background: Atrial fibrillation (AF) is common among people with stroke. Anticoagulation medications can be used to manage the deleterious impact of AF after stroke, however, may not be prescribed due to concerns about post-stroke falls and decreased functioning. Thus, the purpose of this study was to identify, among people with stroke and AF, predictors of anticoagulation prescription at hospital discharge.Methods: This is a secondary analysis of a retrospective cohort study of data retrieved via medical records, including National Institutes of Health Stroke Scale score, Functional Independence Measure (FIM) motor score (motor or physical function), ambulation on second day of hospitalization, Morse Falls Scale (fall risk) and HAS-BLED score (Hypertension; Abnormal renal and liver function; Stroke; Bleeding; Labile INRs; Elderly >65; and Drugs or alcohol). Data analyses included bivariate comparisons between people with and without anticoagulation at discharge. Logistic-regression modeling was used to assess predictors of discharge anticoagulation.Results: There were 334 subjects included in the analyses, whose average age was 75 years old. Anticoagulation was prescribed at discharge for 235 (70%) of patients. In the adjusted regression analyses, only the FIM motor score (adjusted OR = 1.015, 95% CI 1.001-1.028) and the HAS-BLED score (adjusted OR = 0.36, 95% CI 0.22-0.58) were significantly associated with anticoagulation prescription at discharge.Conclusion: It appears that in this sample, post-stroke anticoagulation decisions appear to be made based on clinical factors associated with bleed risk and motor deficits or physical functioning. However, opportunities may exist for improving clinician documentation of specific reasoning for non-anticoagulation prescription. JF - QJM: An International Journal of Medicine AU - Schmid, A A AU - Ofner, S AU - Shorr, R I AU - Williams, L S AU - Bravata, D M AD - From the Department of Occupational Therapy, College of Health and Human Sciences, Colorado State University, Fort Collins, CO, VA HSR&D Stroke Quality Enhancement Research Initiative (QUERI), Indianapolis, IN, Department of Biostatistics, Indiana University, Indianapolis, IN, GRECC (182), Malcom Randall VAMC, Gainesville, FL, Department of Epidemiology, University of Florida, Gainesville, FL, Roudebush Veterans Administration (VA) Medical Center, Health Services Research and Development (HSR&D) Center for Health Information and Communication, Indianapolis, IN, Indiana University Center for Aging Research, Indianapolis, IN, Regenstrief Institute, Inc., Indianapolis, IN, Department of Neurology, Indiana University, School of Medicine and Department of Medicine, Indiana University, School of Medicine, Indianapolis, IN, USA Y1 - 2015/03/29/ PY - 2015 DA - 2015 Mar 29 SP - 189 EP - 196 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 108 IS - 3 SN - 1460-2725, 1460-2725 KW - Physical Education Index KW - Alcohol KW - Analysis KW - Stroke KW - Liver KW - Patients KW - Kidneys KW - Modeling KW - Hypertension KW - Hospitals KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811909380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=QJM%3A+An+International+Journal+of+Medicine&rft.atitle=Bleeding+risk%2C+physical+functioning+and+non-use+of+anticoagulation+among+patients+with+stroke+and+atrial+fibrillation&rft.au=Schmid%2C+A+A%3BOfner%2C+S%3BShorr%2C+R+I%3BWilliams%2C+L+S%3BBravata%2C+D+M&rft.aulast=Schmid&rft.aufirst=A&rft.date=2015-03-29&rft.volume=108&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=QJM%3A+An+International+Journal+of+Medicine&rft.issn=14602725&rft_id=info:doi/10.1093%2Fqjmed%2Fhcu176 LA - English DB - Physical Education Index N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Alcohol; Analysis; Stroke; Liver; Patients; Kidneys; Modeling; Hospitals; Hypertension DO - http://dx.doi.org/10.1093/qjmed/hcu176 ER - TY - RPRT T1 - SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER (SFVAMC) LONG RANGE DEVELOPMENT PLAN, FORT MILEY, SAN FRANCISCO, CALIFORNIA (DRAFT SUPPLEMENT TO THE DRAFT ENVIRONMENTAL IMPACT STATEMENT OF AUGUST 2012) . AN - 16390501; 16443 AB - PURPOSE: This Supplemental Draft EIS evaluates potential environmental impacts resulting from implementation of the VA Proposed Action. VAs Proposed Action is an LRDP that supports the mission of SFVAMC to provide for the health care needs of Bay Area and North Coast Veterans by providing for the renovation, expansion, and operation of the SFVAMC Fort Miley Campus within San Francisco County. The purpose of the Proposed Action is to meet the Veterans Health Administration mission of providing comprehensive, high quality health care services that improve the health and well-being of Veterans and other eligible persons in the San Francisco Bay Area and Northern California. VAs need for the Proposed Action is to address the areas current and future capacity issues brought about by the growing Veteran population, to better serve the ever-changing health care needs of the growing Veteran population, and to provide safe and appropriate facilities for providing health care services and conducting research. This Supplemental Draft EIS analyzes three action alternatives that would involve implementation of an LRDP. All three action alternatives would include seismic retrofit, demolition, new construction, and operation of VA clinical, research, administrative, and parking structures. Also evaluated is the No Action Alternative, in which VA would continue operation and maintenance of the existing medical center at Fort Miley. Alternative 1 has been identified by VA as the Preferred Alternative. JF - EPA number: 150066, Draft Supplement EIS, March 20, 2015 Y1 - 2015/03/20/ PY - 2015 DA - 2015 Mar 20 KW - Land Use KW - Air Quality KW - Air Quality Assessments KW - Archaeological Sites KW - Buildings KW - Cultural Resources Assessments KW - Demolition KW - Historic Districts KW - Hospitals KW - Parking KW - Research Facilities KW - Section 106 Statements KW - Traffic Analyses KW - California UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16390501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=Leeyup&rft.date=2009-07-01&rft.volume=102&rft.issue=1&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurophysiology&rft.issn=00223077&rft_id=info:doi/10.1152%2Fjn.90769.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Veteran Affairs, Veterans Health Administration, San Francisco, California N1 - Date revised - 2016-04-22 N1 - SuppNotes - Draft. Preparation date: March 20, 2015 N1 - Last updated - 2016-04-25 ER - TY - JOUR T1 - Neural correlates of adherence to extended-release naltrexone pharmacotherapy in heroin dependence. AN - 1664779142; 25781230 AB - Injectable extended-release naltrexone (XRNTX) presents an effective therapeutic strategy for opioid addiction, however its utility could be hampered by poor adherence. To gain a better insight into this phenomenon, we utilized blood oxygenation level-dependent functional magnetic resonance imaging (fMRI) in conjunction with a validated cue-induced craving procedure to examine neural correlates of XRNTX adherence. We operationalized treatment adherence as the number of monthly XRNTX injections (range: 0-3) administered to a group of fully detoxified heroin-dependent subjects (n=32). Additional outcomes included urine toxicology screening and self-reported tobacco use. The presented heroin-related visual cues reliably elicited heroin craving in all tested subjects. Nine, five, three and 15 of the participants, respectively, received zero, one, two and three XRNTX injections, predicted by the individual baseline fMRI signal change in response to the cues in the medial prefrontal cortex, a brain region involved in inhibitory self-control and emotional appraisal. The incidence of opioid-positive urines during the XRNTX therapy was low and remained about half the pre-treatment rate after the XRNTX ended. During the treatment, cigarette smoking behaviors followed patterns of opioid use, while cocaine consumption was increased with reductions in opioid use. The present data support the hypothesis that medial prefrontal cortex functions are involved in adherence to opioid antagonist therapy. A potential role of concurrent non-opioid addictive substances consumption during the XRNTX pharmacotherapy warrants further investigation. Our findings set the stage for further bio-behavioral investigations of the mechanisms of relapse prevention in opioid dependence. JF - Translational psychiatry AU - Wang, A-L AU - Elman, I AU - Lowen, S B AU - Blady, S J AU - Lynch, K G AU - Hyatt, J M AU - O'Brien, C P AU - Langleben, D D AD - Annenberg Public Policy Center, University of Pennsylvania, Philadelphia, PA, USA. ; Cambridge Health Alliance, Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA. ; Brain Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA. ; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ; Department of Criminology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA. ; 1] Annenberg Public Policy Center, University of Pennsylvania, Philadelphia, PA, USA [2] Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA [3] Behavioral Health Service, Veterans Administration Medical Center, Philadelphia, PA, USA. Y1 - 2015/03/17/ PY - 2015 DA - 2015 Mar 17 SP - 1 VL - 5 KW - Narcotic Antagonists KW - 0 KW - Naltrexone KW - 5S6W795CQM KW - Index Medicus KW - Magnetic Resonance Imaging KW - Craving KW - Narcotic Antagonists -- administration & dosage KW - Narcotic Antagonists -- therapeutic use KW - Humans KW - Adult KW - Cues KW - Male KW - Female KW - Brain -- physiopathology KW - Naltrexone -- administration & dosage KW - Patient Compliance -- statistics & numerical data KW - Patient Compliance -- psychology KW - Heroin Dependence -- physiopathology KW - Heroin Dependence -- drug therapy KW - Heroin Dependence -- psychology KW - Naltrexone -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664779142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Translational+psychiatry&rft.atitle=Neural+correlates+of+adherence+to+extended-release+naltrexone+pharmacotherapy+in+heroin+dependence.&rft.au=Wang%2C+A-L%3BElman%2C+I%3BLowen%2C+S+B%3BBlady%2C+S+J%3BLynch%2C+K+G%3BHyatt%2C+J+M%3BO%27Brien%2C+C+P%3BLangleben%2C+D+D&rft.aulast=Wang&rft.aufirst=A-L&rft.date=2015-03-17&rft.volume=5&rft.issue=&rft.spage=e531&rft.isbn=&rft.btitle=&rft.title=Translational+psychiatry&rft.issn=2158-3188&rft_id=info:doi/10.1038%2Ftp.2015.20 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-20 N1 - Date created - 2015-03-18 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Neuroimage. 2001 Dec;14(6):1370-86 [11707093] Drug Alcohol Depend. 2012 Jul 1;124(1-2):113-20 [22265192] Int J Environ Res Public Health. 2012 Mar;9(3):932-42 [22690174] Neuroradiology. 2012 Sep;54(9):1015-25 [22744798] J Clin Psychiatry. 2012 Aug;73(8):e1056-61 [22967782] Lancet. 2012 Dec 15;380(9859):2095-128 [23245604] Psychopharmacology (Berl). 2013 Jan;225(1):127-40 [22829433] J Neurosci. 2013 Mar 6;33(10):4584-93 [23467374] Subst Abus. 2013;34(2):94-6 [23577900] Curr Drug Abuse Rev. 2013 Mar;6(1):77-84 [23506370] Life Sci. 2013 Sep 17;93(9-11):373-9 [23891777] Nicotine Tob Res. 2013 Oct;15(10):1705-13 [23572466] Drug Alcohol Depend. 2013 Nov 1;133(1):80-5 [23827259] J Anal Toxicol. 2007 Oct;31(8):453-61 [17988459] Eur Psychiatry. 2007 Nov;22(8):540-8 [17596918] Eur J Pharmacol. 2008 Jan 28;579(1-3):160-6 [17977528] Am J Psychiatry. 2008 Mar;165(3):390-4 [18056224] JAMA. 2009 Jan 14;301(2):183-90 [19141766] Alcohol Clin Exp Res. 2009 Mar;33(3):383-93 [19053977] Brain Res. 2009 Oct 13;1293:61-75 [19332030] Epilepsy Behav. 2009 Oct;16(2):288-97 [19733509] Br J Psychiatry Suppl. 2009 Nov;52:S37-42 [19880915] Soc Cogn Affect Neurosci. 2009 Dec;4(4):423-8 [20035017] J Opioid Manag. 2010 Jul-Aug;6(4):300-3 [20862910] Nat Neurosci. 2011 Apr;14(4):426-7 [21358641] Mayo Clin Proc. 2011 Apr;86(4):304-14 [21389250] JAMA. 2011 Apr 6;305(13):1346-7 [21467287] Neuropharmacology. 2011 Jun;60(7-8):1209-20 [21108953] Lancet. 2011 Apr 30;377(9776):1506-13 [21529928] Eur Radiol. 2011 Nov;21(11):2369-87 [21710268] Nat Rev Neurosci. 2011 Nov;12(11):652-69 [22011681] J Stud Alcohol Drugs. 2011 Nov;72(6):1012-8 [22051215] Psychopharmacology (Berl). 2012 Apr;220(3):559-64 [21960180] J Neurosci. 2012 Apr 4;32(14):4982-91 [22492053] Emerg Med J. 2002 May;19(3):264-5 [11971848] Am J Psychiatry. 2002 Oct;159(10):1642-52 [12359667] Neuroimage. 2002 Oct;17(2):825-41 [12377157] Hum Brain Mapp. 2002 Nov;17(3):143-55 [12391568] Indian J Med Sci. 2002 Oct;56(10):495-500 [12712760] Stat Methods Med Res. 2003 Oct;12(5):401-18 [14599003] Neuropsychologia. 1971 Mar;9(1):97-113 [5146491] Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5675-9 [1608978] Prog Neurobiol. 2013 Oct;109:1-27 [23827972] J Sex Med. 2014 Jan;11(1):22-32 [24344738] Acad Emerg Med. 2014 Jan;21(1):31-9 [24552522] Addict Biol. 2014 Mar;19(2):262-71 [22747521] BMJ Open. 2014;4(3):e004393 [24633528] Contemp Clin Trials. 2014 Mar;37(2):209-18 [24384538] N Engl J Med. 2014 May 29;370(22):2063-6 [24758595] Addict Biol. 2014 Jul;19(4):733-42 [23252742] Hum Brain Mapp. 2000 Jul;10(3):120-31 [10912591] Addiction. 2000 Aug;95 Suppl 2:S177-87 [11002913] Drug Alcohol Depend. 2001 Jan 1;61(2):163-72 [11137281] Arch Gen Psychiatry. 2001 May;58(5):503-8 [11343531] Med Image Anal. 2001 Jun;5(2):143-56 [11516708] Arch Gen Psychiatry. 2006 Feb;63(2):210-8 [16461865] Arch Intern Med. 2006 Jun 26;166(12):1280-7 [16801510] Hum Brain Mapp. 2006 Aug;27(8):652-61 [16281289] Addict Behav. 2006 Dec;31(12):2304-8 [16564643] Addict Behav. 2007 May;32(5):938-49 [16887281] J Addict Dis. 2007;26(1):61-70 [17439869] Exp Clin Psychopharmacol. 2007 Apr;15(2):134-43 [17469937] Drug Alcohol Depend. 2007 Dec 1;91(2-3):289-92 [17681716] J Pharmacol Exp Ther. 2011 Feb;336(2):488-95 [21051498] Am J Addict. 2011 Mar-Apr;20(2):106-12 [21314752] Cochrane Database Syst Rev. 2011;(2):CD001333 [21328250] Neuroimage. 2011 Apr 15;55(4):1825-35 [21272655] Magn Reson Med. 1992 Jun;25(2):390-7 [1614324] J Subst Abuse Treat. 1992;9(3):199-213 [1334156] Am J Emerg Med. 1993 Jan;11(1):96-7 [8447884] NIDA Res Monogr. 1993;137:73-95 [8289929] Magn Reson Med. 1995 May;33(5):636-47 [7596267] J Toxicol Clin Toxicol. 1996;34(4):409-16 [8699555] Neuroimage. 1996 Dec;4(3 Pt 1):223-35 [9345513] IEEE Trans Med Imaging. 2004 Feb;23(2):137-52 [14964560] Neuron. 2004 Sep 16;43(6):897-905 [15363399] N Engl J Med. 2014 Sep 4;371(10):932-43 [25184865] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/tp.2015.20 ER - TY - JOUR T1 - The Dynamics of Psychiatric Bed Use in General Hospitals AN - 1708525163; 201506197 AB - This study examines general hospitals' adjustments in psychiatric bed utilization practices in response to increases in psychiatric inpatient admissions. Using panel data from 439 hospitals, monthly observations (N = 7,831) between 2007 and 2010 on psychiatric admissions, psychiatric bed occupancy rates, and average length-of-stay were created for psychiatric inpatients. In fixed-effects regressions, an increase in psychiatric admissions was associated with an increase in the probability of psychiatric bed use exceeding 100 % occupancy and with a reduction of mean length-of-stay. These results were confirmed in instrumental variables models. General hospitals may dynamically adjust bed utilization practices in response to changing psychiatric bed needs. An implication of this dynamic adjustment model is that bed shortages are likely to be local, transitory events. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - Slade, Eric P AU - Goldman, Howard H AD - U.S. Department of Veterans Affairs, VA Capitol Healthcare Network Mental Illness Research, Education, and Clinical Center, 10 N. Greene Street, Baltimore, MD, 21201, USA eslade@psych.umaryland.edu Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 139 EP - 146 PB - Springer, Dordrecht The Netherlands VL - 42 IS - 2 SN - 0894-587X, 0894-587X KW - Scarcity KW - Mental Hospitals KW - Adjustment KW - Psychiatry KW - Hospitals KW - article KW - 6120: social work practice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1708525163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=The+Dynamics+of+Psychiatric+Bed+Use+in+General+Hospitals&rft.au=Slade%2C+Eric+P%3BGoldman%2C+Howard+H&rft.aulast=Slade&rft.aufirst=Eric&rft.date=2015-03-01&rft.volume=42&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-014-0554-4 LA - English DB - Social Services Abstracts N1 - Date revised - 2015-09-01 N1 - Number of references - 18 N1 - Last updated - 2016-09-28 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Psychiatry; Hospitals; Adjustment; Mental Hospitals; Scarcity DO - http://dx.doi.org/10.1007/s10488-014-0554-4 ER - TY - JOUR T1 - Quality Management and Federal Workers' Compensation: The Veterans Health Administration Workers' Compensation Program Model AN - 1680447972; PQ0001516826 AB - Objective: The federal workers' compensation program includes under a single employer five commonly encountered roles and responsibilities-injured patient, clinical provider, third-party administrator, adjudicator, and insurer. Data within the Veterans Health Administration (VHA) provide a unique opportunity to apply a simple model of health care quality improvement, exploring interactions between structures, processes, and outcomes. Methods: A facility survey identified reporting structures, levels of education and training, policies and processes, tool availability and use, and perceptions of role adherence. Administrative data included process and outcome metrics, including short-term disability, long-term disability, and lost time cases. Results: Improved collaboration between clinical and administrative staff within VHA and with the Department of Labor was associated with improved performance. Conclusions: Applying a clinical quality improvement model clarifies roles, expectations, and likely relationships for improved program management. JF - Journal of Occupational and Environmental Medicine AU - Hodgson, Michael J AU - Mohr, David C AU - Lipkowitz-Eaton, Jennifer AU - Rodrigues, Dianne AU - Moreau, Sarah AU - McPhaul, Kate AD - War-Related Illness and Injury Study Center, Office of Public Health, Veterans Health Administration; Occupational Health Strategic Health Care Group, Office of Public Health, michael.hodgson@va.gov PY - 2015 SP - S36 EP - S42 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 3S SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Workers' compensation KW - Education KW - Health care KW - Training KW - Perception KW - Disabilities KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680447972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Quality+Management+and+Federal+Workers%27+Compensation%3A+The+Veterans+Health+Administration+Workers%27+Compensation+Program+Model&rft.au=Hodgson%2C+Michael+J%3BMohr%2C+David+C%3BLipkowitz-Eaton%2C+Jennifer%3BRodrigues%2C+Dianne%3BMoreau%2C+Sarah%3BMcPhaul%2C+Kate&rft.aulast=Hodgson&rft.aufirst=Michael&rft.date=2015-03-01&rft.volume=57&rft.issue=3S&rft.spage=S36&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000375 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Workers' compensation; Education; Health care; Perception; Training; Disabilities DO - http://dx.doi.org/10.1097/JOM.0000000000000375 ER - TY - JOUR T1 - A Brief Summary of Workers' Compensation Performance Improvement Projects 2008 to 2012 in the Veterans Health Administration AN - 1680446679; PQ0001516828 AB - Background: The Veterans Health Administration undertook a series of performance improvement projects (PIP) using local initiatives identified through a national committee of regional workers' compensation representatives. Methods: A steering committee identified five types of risks and interventions that were considered worthwhile. They defined performance metrics as outcome measures and distinguished short-term from long-term disability management success. Results: Eight specific PIPs were implemented. No statistically significant differences in the planned outcome metrics were identified, although cost-benefit evaluations did identify a benefit. Conclusions: Conducting quantitative PIPs in a large system requires top management commitment, sequestration of funds, and mature systems. JF - Journal of Occupational and Environmental Medicine AU - Hodgson, Michael J AD - War-Related Illness and Injury Study Center, Washington DC VAMC, 50 Irving Street NW, Washington DC 20422, michael.hodgson@va.gov PY - 2015 SP - S43 EP - S46 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 3S SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Workers' compensation KW - Funds KW - Committees KW - Disabilities KW - Intervention KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680446679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=A+Brief+Summary+of+Workers%27+Compensation+Performance+Improvement+Projects+2008+to+2012+in+the+Veterans+Health+Administration&rft.au=Hodgson%2C+Michael+J&rft.aulast=Hodgson&rft.aufirst=Michael&rft.date=2015-03-01&rft.volume=57&rft.issue=3S&rft.spage=S43&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000403 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Workers' compensation; Funds; Disabilities; Committees; Intervention DO - http://dx.doi.org/10.1097/JOM.0000000000000403 ER - TY - JOUR T1 - Impact of Clinical Quality on Employee Choice of Providers for Workers' Compensation-Related Medical Care AN - 1680445046; PQ0001516825 AB - Objective: The study examined the relationship between onsite occupational health practice characteristics, provider choice, and workers' compensation outcome metrics. Methods: Cross-sectional survey of 140 medical center occupational health clinics within the Department of Veterans Affairs. Multivariate regression models examined how specific clinical quality factors influenced provider choice and workers' compensation measures. Results: Several practice characteristics were associated with higher rates of in-house care selection-longer hours of operation, greater availability of workers' compensation-related medical services, clinic administration by a board certified physician, physician tenure, and adherence to clinical practice guidelines. Access to onsite, occupational and environmental medicine certified physician-directed care was associated with reductions in disability duration among injured healthcare workers. Conclusions: These findings suggest that occupational medicine board certification can positively impact provider choice among fully insured patients, which may have implications for other healthcare systems. JF - Journal of Occupational and Environmental Medicine AU - Eaton, Jennifer L AU - Mohr, David C AU - Gallarde, Sheryl AU - Hodgson, Michael J AD - Occupational Health Group, Office of Public Health, Veterans Health Administration, 1717 H St NW Rm 504, Washington, DC 20006; War Related Illness and Injury Study Center, VA Medical Center, Washington, DC, Jennifer.Lipkowitz-Eaton@va.gov PY - 2015 SP - S31 EP - S35 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 3S SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Workers' compensation KW - Health care KW - Disabilities KW - Guidelines KW - Certification KW - Medical personnel KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680445046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Impact+of+Clinical+Quality+on+Employee+Choice+of+Providers+for+Workers%27+Compensation-Related+Medical+Care&rft.au=Eaton%2C+Jennifer+L%3BMohr%2C+David+C%3BGallarde%2C+Sheryl%3BHodgson%2C+Michael+J&rft.aulast=Eaton&rft.aufirst=Jennifer&rft.date=2015-03-01&rft.volume=57&rft.issue=3S&rft.spage=S31&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000387 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Workers' compensation; Health care; Disabilities; Guidelines; Certification; Medical personnel; Occupational health DO - http://dx.doi.org/10.1097/JOM.0000000000000387 ER - TY - JOUR T1 - Reviewing Manuscripts for the Journal of Genetic Counseling: Practical Suggestions AN - 1673613764 AB - The Journal of Genetic Counseling is the literary voice of our profession and our scholarship is only as good as the articles that are accepted. A quality review assists the editor in making publication decisions and enhances the manuscripts that are published, ultimately benefitting our profession and the public. Perhaps you are new to the reviewing process and/or you wonder about the sorts of things that make for a good review. The purpose of this article is to provide general guidance to enhance your experience of peer review. While the focus is research manuscripts, many of the guidelines will be similar for case reports, reviews, or professional issues papers. JF - Journal of Genetic Counseling AU - Venne, Vickie AD - Genomic Medicine Service, Salt Lake City, UT, USA Vickie.Venne@va.gov; Genomic Medicine Service, Salt Lake City, UT, USA Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 189 EP - 192 CY - New York PB - Springer Science & Business Media VL - 24 IS - 2 SN - 1059-7700 KW - Psychology KW - Counselling KW - Genetic counselling KW - Guidance KW - Manuscripts KW - Professional issues UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673613764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Genetic+Counseling&rft.atitle=Reviewing+Manuscripts+for+the+Journal+of+Genetic+Counseling%3A+Practical+Suggestions&rft.au=Venne%2C+Vickie&rft.aulast=Venne&rft.aufirst=Vickie&rft.date=2015-03-01&rft.volume=24&rft.issue=2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Journal+of+Genetic+Counseling&rft.issn=10597700&rft_id=info:doi/10.1007%2Fs10897-014-9802-8 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-03-31 N1 - Last updated - 2016-05-12 DO - http://dx.doi.org/10.1007/s10897-014-9802-8 ER - TY - JOUR T1 - Smiling in a Job Interview: When Less Is More AN - 1665168164 AB - Two studies examined the effect of applicants’ smiling on hireability. In a pre-test study, participants were asked to rate the expected behavior for four types of applicants. Newspaper reporter applicants were expected to be more serious than applicants for other jobs. In Study 1, participants were randomly assigned to be an applicant or interviewer for a newspaper reporting job. Smiling was negatively related to hiring, and smiling mediated the relation between applicants’ motivation to make a good impression and hiring. Hiring was maximized when applicants smiled less in the middle of the interview relative to the start and end. In Study 2, participants watched Study 1 clips and were randomly assigned to believe the applicants were applying to one of four jobs. Participants rated more suitability when applicants smiled less, especially for jobs associated with a serious demeanor. This research shows that job type is an important moderator of the impact of smiling on hiring. JF - The Journal of Social Psychology AU - Ruben, Mollie A AU - Hall, Judith A AU - Schmid Mast, Marianne AD - U.S. Department of Veterans Affairs, Northeastern University, University of Lausanne ; U.S. Department of Veterans Affairs; Northeastern University; University of Lausanne Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 107 EP - 126 CY - Philadelphia PB - Taylor & Francis Ltd. VL - 155 IS - 2 SN - 0022-4545 KW - Psychology KW - Applicants KW - Hiring KW - Job applicants KW - Motivation KW - Suitability KW - Nonverbal Communication KW - Job Search KW - 0312:social psychology; personality & social roles (individual traits, social identity, adjustment, conformism, & deviance) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665168164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Social+Psychology&rft.atitle=Smiling+in+a+Job+Interview%3A+When+Less+Is+More&rft.au=Ruben%2C+Mollie+A%3BHall%2C+Judith+A%3BSchmid+Mast%2C+Marianne&rft.aulast=Ruben&rft.aufirst=Mollie&rft.date=2015-03-01&rft.volume=155&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Social+Psychology&rft.issn=00224545&rft_id=info:doi/10.1080%2F00224545.2014.972312 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); Sociological Abstracts N1 - Date revised - 2015-02-26 N1 - Last updated - 2016-09-05 DO - http://dx.doi.org/10.1080/00224545.2014.972312 ER - TY - JOUR T1 - Treatment for preventing tuberculosis in children and adolescents: a randomized clinical trial of a 3-month, 12-dose regimen of a combination of rifapentine and isoniazid. AN - 1660662110; 25580725 AB - Three months of a once-weekly combination of rifapentine and isoniazid for treatment of latent tuberculosis infection is safe and effective for persons 12 years or older. Published data for children are limited. To compare treatment safety and assess noninferiority treatment effectiveness of combination therapy with rifapentine and isoniazid vs 9 months of isoniazid treatment for latent tuberculosis infection in children. A pediatric cohort nested within a randomized, open-label clinical trial conducted from June 11, 2001, through December 17, 2010, with follow-up through September 5, 2013, in 29 study sites in the United States, Canada, Brazil, Hong Kong (China), and Spain. Participants were children (aged 2-17 years) who were eligible for treatment of latent tuberculosis infection. Twelve once-weekly doses of the combination drugs, given with supervision by a health care professional, for 3 months vs 270 daily doses of isoniazid, without supervision by a health care professional, for 9 months. We compared rates of treatment discontinuation because of adverse events (AEs), toxicity grades 1 to 4, and deaths from any cause. The equivalence margin for the comparison of AE-related discontinuation rates was 5%. Tuberculosis disease diagnosed within 33 months of enrollment was the main end point for testing effectiveness. The noninferiority margin was 0.75%. Of 1058 children enrolled, 905 were eligible for evaluation of effectiveness. Of 471 in the combination-therapy group, 415 (88.1%) completed treatment vs 351 of 434 (80.9%) in the isoniazid-only group (P = .003). The 95% CI for the difference in rates of discontinuation attributed to an AE was -2.6 to 0.1, which was within the equivalence range. In the safety population, 3 of 539 participants (0.6%) who took the combination drugs had a grade 3 AE vs 1 of 493 (0.2%) who received isoniazid only. Neither arm had any hepatotoxicity, grade 4 AEs, or treatment-attributed death. None of the 471 in the combination-therapy group developed tuberculosis vs 3 of 434 (cumulative rate, 0.74%) in the isoniazid-only group, for a difference of -0.74% and an upper bound of the 95% CI of the difference of +0.32%, which met the noninferiority criterion. Treatment with the combination of rifapentine and isoniazid was as effective as isoniazid-only treatment for the prevention of tuberculosis in children aged 2 to 17 years. The combination-therapy group had a higher treatment completion rate than did the isoniazid-only group and was safe. clinicaltrials.gov Identifier: NCT00023452. JF - JAMA pediatrics AU - Villarino, M Elsa AU - Scott, Nigel A AU - Weis, Stephen E AU - Weiner, Marc AU - Conde, Marcus B AU - Jones, Brenda AU - Nachman, Sharon AU - Oliveira, Ricardo AU - Moro, Ruth N AU - Shang, Nong AU - Goldberg, Stefan V AU - Sterling, Timothy R AU - International Maternal Pediatric and Adolescents AIDS Clinical Trials Group AU - Tuberculosis Trials Consortium AD - Division of Tuberculosis Elimination, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia. ; Division of Tuberculosis Elimination, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia2CDC Foundation, Atlanta, Georgia. ; Department of Medicine, University of North Texas Health Science Center at Ft Worth. ; Department of Medicine, Audie L. Murphy San Antonio Veterans Administration Medical Center, San Antonio, Texas. ; Department of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. ; Department of Medicine, University of Southern California, Los Angeles. ; Department of Pediatrics, State University of New York at Stony Brook. ; Department of Pediatrics, Pediatric Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. ; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee. ; International Maternal Pediatric and Adolescents AIDS Clinical Trials Group ; Tuberculosis Trials Consortium Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 247 EP - 255 VL - 169 IS - 3 KW - Antitubercular Agents KW - 0 KW - Isoniazid KW - V83O1VOZ8L KW - Rifampin KW - VJT6J7R4TR KW - rifapentine KW - XJM390A33U KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Humans KW - Treatment Outcome KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Isoniazid -- therapeutic use KW - Rifampin -- analogs & derivatives KW - Rifampin -- adverse effects KW - Antitubercular Agents -- administration & dosage KW - Rifampin -- therapeutic use KW - Isoniazid -- adverse effects KW - Rifampin -- administration & dosage KW - Latent Tuberculosis -- prevention & control KW - Antitubercular Agents -- adverse effects KW - Isoniazid -- administration & dosage KW - Antitubercular Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660662110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA+pediatrics&rft.atitle=Treatment+for+preventing+tuberculosis+in+children+and+adolescents%3A+a+randomized+clinical+trial+of+a+3-month%2C+12-dose+regimen+of+a+combination+of+rifapentine+and+isoniazid.&rft.au=Villarino%2C+M+Elsa%3BScott%2C+Nigel+A%3BWeis%2C+Stephen+E%3BWeiner%2C+Marc%3BConde%2C+Marcus+B%3BJones%2C+Brenda%3BNachman%2C+Sharon%3BOliveira%2C+Ricardo%3BMoro%2C+Ruth+N%3BShang%2C+Nong%3BGoldberg%2C+Stefan+V%3BSterling%2C+Timothy+R%3BInternational+Maternal+Pediatric+and+Adolescents+AIDS+Clinical+Trials+Group%3BTuberculosis+Trials+Consortium&rft.aulast=Villarino&rft.aufirst=M&rft.date=2015-03-01&rft.volume=169&rft.issue=3&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=JAMA+pediatrics&rft.issn=2168-6211&rft_id=info:doi/10.1001%2Fjamapediatrics.2014.3158 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-30 N1 - Date created - 2015-03-03 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00023452; ClinicalTrials.gov N1 - SuppNotes - Comment In: Indian Pediatr. 2015 May;52(5):421-5 [26061929] JAMA Pediatr. 2015 Mar;169(3):208-10 [25581905] Erratum In: JAMA Pediatr. 2015 Sep;169(9):878 [26348861] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1001/jamapediatrics.2014.3158 ER - TY - JOUR T1 - Health Care Employee Perceptions of Patient-Centered Care AN - 1660419597; PQ0001025656 AB - Given the importance of health care employees in the delivery of patient-centered care, understanding their unique perspectives is essential for quality improvement. The purpose of this study was to use photovoice to evaluate perceptions and experiences around patient-centered care among U.S. Veterans Affairs (VA) health care employees. We asked participants to take photographs of salient features in their environment related to patient-centered care. We used the photographs to facilitate dialogue during follow-up interviews. Twelve VA health care employees across two VA sites participated in the project. Although most participants felt satisfied with their work environment and experiences at the VA, they identified several areas for improvement. These included a need for more employee health and wellness initiatives and a need for enhanced opportunities for training and professional growth. Application of photovoice enabled us to learn about employees' unique perspectives around patient-centered care while engaging them in an evaluation of care delivery. JF - Qualitative Health Research AU - Balbale, Salva Najib AU - Turcios, Stephanie AU - LaVela, Sherri L AD - United States Department of Veterans Affairs, Hines, Illinois, USA Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 417 EP - 425 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 25 IS - 3 SN - 1049-7323, 1049-7323 KW - Health & Safety Science Abstracts KW - health care KW - health care professionals KW - photography / photovoice KW - quality improvement KW - research, qualitative KW - Health care KW - Perception KW - Training KW - Occupational health KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660419597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Qualitative+Health+Research&rft.atitle=Health+Care+Employee+Perceptions+of+Patient-Centered+Care&rft.au=Balbale%2C+Salva+Najib%3BTurcios%2C+Stephanie%3BLaVela%2C+Sherri+L&rft.aulast=Balbale&rft.aufirst=Salva&rft.date=2015-03-01&rft.volume=25&rft.issue=3&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Qualitative+Health+Research&rft.issn=10497323&rft_id=info:doi/10.1177%2F1049732314553011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 34 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Health care; Training; Perception; Occupational health DO - http://dx.doi.org/10.1177/1049732314553011 ER - TY - JOUR T1 - Obesity related risk of sudden cardiac death in the atherosclerosis risk in communities study AN - 1808699310; PQ0003460396 AB - ObjectiveTo examine the association of body mass index (BMI), waist circumference (WC) and waist hip ratio (WHR) with sudden cardiac death (SCD) in community dwelling individuals.MethodsData from a multicentre, prospective, cohort study of 14941 men and women (African American, and white), aged 45-64years, participating in the Atherosclerosis Risk in Communities study was analysed. Obesity measures were assessed at baseline (1987-1989). SCD was adjudicated by a committee.ResultsAt enrolment mean plus or minus SD age of the participants was 54 plus or minus 6 years (55% female; 26% African American). During 12.6 plus or minus 2.5 years of follow-up, 253 SCD occurred (incidence rate 1.34/100 person-years). The association between obesity and SCD differed by smoking status (interaction p less than or equal to 0.01). In models adjusting for age, sex, race, study centre and education level, SCD risk was positively associated (p0.95 in women; >1.01 in men) had double the risk of SCD (HR 2.03, 95% CI 1.19 to 3.46; incidence rate 1.43/1000 person-years) versus those with normal WHR.ConclusionsGeneral obesity is associated with increased risk of SCD in middle-aged, non-smoking individuals, mediated by traditional cardiovascular risk factors. Central obesity, however, is independently associated with SCD by pathways that remain to be elucidated. JF - Heart AU - Adabag, Selcuk AU - Huxley, Rachel R AU - Lopez, Faye L AU - Chen, Lin Y AU - Sotoodehnia, Nona AU - Siscovick, David AU - Deo, Rajat AU - Konety, Suma AU - Alonso, Alvaro AU - Folsom, Aaron R AD - Division of Cardiology, Veterans Administration Medical Center, , Minneapolis, Minnesota, USA Y1 - 2015/02/01/ PY - 2015 DA - 2015 Feb 01 SP - 215 EP - 221 PB - British Medical Association, BMA House Square London WC1H 9JP United Kingdom VL - 101 IS - 3 SN - 1355-6037, 1355-6037 KW - Physical Education Index; Biotechnology and Bioengineering Abstracts KW - Age KW - Death KW - Blacks KW - Lipids KW - Body mass KW - Women KW - Arteriosclerosis KW - Models KW - Smoking KW - Risk factors KW - Races KW - Sex KW - Heart diseases KW - Heart KW - Obesity KW - Men KW - Blood diseases KW - Coronary heart disease KW - Diabetes mellitus KW - Hypertrophy KW - Waist KW - Cardiovascular diseases KW - Body mass index KW - Hip KW - Hypertension KW - W 30965:Miscellaneous, Reviews KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808699310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Orthopsychiatry&rft.atitle=Effects+of+Social+Support+and+Conflict+on+Parenting+Among+Homeless+Mothers&rft.au=Marra%2C+Jaime+V%3BMcCarthy%2C+Elissa%3BLin%2C+Hsiu-Ju%3BFord%2C+Julian%3BRodis%2C+Eleni%3BFrisman%2C+Linda+K&rft.aulast=Marra&rft.aufirst=Jaime&rft.date=2009-07-01&rft.volume=79&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Orthopsychiatry&rft.issn=00029432&rft_id=info:doi/10.1037%2Fa0017241 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Obesity; Death; Waist; Men; Blacks; Body mass; Women; Blood diseases; Heart diseases; Heart; Age; Lipids; Arteriosclerosis; Coronary heart disease; Models; Diabetes mellitus; Smoking; Hypertrophy; Risk factors; Cardiovascular diseases; Body mass index; Races; Hypertension; Hip; Sex DO - http://dx.doi.org/10.1136/heartjnl-2014-306238 ER - TY - JOUR T1 - Typologies of positive psychotic symptoms in methamphetamine dependence AN - 1683503519 AB - Background and Objectives Understanding methamphetamine associated psychotic (MAP) symptom typologies could aid in identifying individuals at risk of progressing to schizophrenia and guide early intervention. Methods Latent class analysis (LCA) of psychotic symptoms collected from 40 ( n=40) methamphetamine dependent individuals with a history of psychotic symptoms but no history of a primary psychotic disorder. Results Three typologies were identified. In one, persecutory delusions dominated (Type 1), in another persecutory delusions were accompanied by hallucinations (Type 2), and in the third a high frequency of all the assessed hallucinatory and delusional symptoms was observed (Type 3). Discussion and Conclusion MAP is a heterogeneous syndrome with positive symptom typologies. Scientific Significance This study represents the first attempt at identifying typologies of MAP and highlights the potential utility of LCA in future large-scale studies. (Am J Addict 2015;24:94–97) JF - The American Journal on Addictions AU - Bousman, Chad A AU - McKetin, Rebecca AU - Burns, Richard AU - Woods, Steven Paul AU - Morgan, Erin E AU - Atkinson, J Hampton AU - Everall, Ian P AU - Grant, Igor AD - Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia., Department of General Practice, University of Melbourne, Parkville, VIC, Australia., Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorne, VIC, Australia., Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia. ; Centre for Research on Ageing, Health and Wellbeing, Australia National University, Canberra, ACT, Australia. ; Department of Psychiatry, University of California, San Diego, San Diego, California. ; Department of Psychiatry, University of California, San Diego, San Diego, California., Veterans Administration San Diego Healthcare System, San Diego, California. ; Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia., Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia., NorthWestern Mental Health, Melbourne, VIC, Australia. ; Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia.; Department of General Practice, University of Melbourne, Parkville, VIC, Australia.; Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorne, VIC, Australia.; Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia. Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 94 EP - 97 CY - Hoboken PB - Wiley Subscription Services, Inc. VL - 24 IS - 2 SN - 1055-0496 KW - Medical Sciences--Psychiatry And Neurology KW - At risk KW - Addicts KW - Delusions KW - Early intervention programmes KW - Hallucinations KW - Latent class analysis KW - Methamphetamine KW - Persecutory ideation KW - Psychoses KW - Psychotic symptoms KW - Schizophrenia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683503519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+on+Addictions&rft.atitle=Typologies+of+positive+psychotic+symptoms+in+methamphetamine+dependence&rft.au=Bousman%2C+Chad+A%3BMcKetin%2C+Rebecca%3BBurns%2C+Richard%3BWoods%2C+Steven+Paul%3BMorgan%2C+Erin+E%3BAtkinson%2C+J+Hampton%3BEverall%2C+Ian+P%3BGrant%2C+Igor&rft.aulast=Bousman&rft.aufirst=Chad&rft.date=2015-02-01&rft.volume=24&rft.issue=2&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+on+Addictions&rft.issn=10550496&rft_id=info:doi/10.1111%2Fajad.12160 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-04-15 N1 - Last updated - 2016-05-13 DO - http://dx.doi.org/10.1111/ajad.12160 ER - TY - JOUR T1 - Mental Health System Historians: Adults with Schizophrenia Describe Changes in Community Mental Health Care Over Time AN - 1673612714 AB - This qualitative study examined changes in community mental health care as described by adults diagnosed with schizophrenia with long-term involvement in the mental health system to situate their experiences within the context of mental health reform movements in the United States. A sample of 14 adults with schizophrenia who had been consumers of mental health services from 12 to 40 years completed interviews about their hospital and outpatient experiences over time and factors that contributed most to their mental health. Overall, adults noted gradual changes in mental health care over time that included higher quality of care, more humane treatment, increased partnership with providers, shorter hospital stays, and better conditions in inpatient settings. Regardless of the mental health reform era in which they were hospitalized, participants described negative hospitalization experiences resulting in considerable personal distress, powerlessness, and trauma. Adults with less than 27 years involvement in the system reported relationships with friends and family as most important to their mental health, while adults with more than 27 years involvement reported mental health services and relationships with professionals as the most important factors in their mental health. The sample did not differ in self-reported use of services during their initial and most recent hospitalization experiences, but differences were found in participants’ reported use of outpatient services over time. Findings underscore the importance of the lived experience of adults with schizophrenia in grounding current discourse on mental health care reform. JF - Psychiatric Quarterly AU - Stein, Catherine H AU - Leith, Jaclyn E AU - Osborn, Lawrence A AU - Greenberg, Sarah AU - Petrowski, Catherine E AU - Jesse, Samantha AU - Kraus, Shane W AU - May, Michael C AD - Department of Psychology, Bowling Green State University, Bowling Green, Ohio, 43403, USA cstein@bgsu.edu cstein@bgsu.edu cstein@bgsu.edu cstein@bgsu.edu cstein@bgsu.edu; Durham North Carolina Veterans Administration Medical Center, Durham, NC, 27705, USA ; New England Mental Illness Research Education and Clinical Centers, VA Connecticut Healthcare System, and Yale School of Medicine, New Haven, CT, 06516, USA ; Metropolitan Family Services, Chicago, IL, 60602, USA ; Department of Psychology, Bowling Green State University, Bowling Green, Ohio, 43403, USA Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 33 EP - 48 CY - New York PB - Springer Science & Business Media VL - 86 IS - 1 SN - 0033-2720 KW - Medical Sciences--Psychiatry And Neurology KW - Community mental health services KW - Adults KW - Change agents KW - Service provision KW - Consumers KW - Discourse KW - Friends KW - Health care KW - Health services KW - Historians KW - Hospitalization KW - Hospitalized KW - Mental health care KW - Mental health services KW - Powerlessness KW - Psychological distress KW - Quality of care KW - Schizophrenia KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673612714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+Quarterly&rft.atitle=Mental+Health+System+Historians%3A+Adults+with+Schizophrenia+Describe+Changes+in+Community+Mental+Health+Care+Over+Time&rft.au=Stein%2C+Catherine+H%3BLeith%2C+Jaclyn+E%3BOsborn%2C+Lawrence+A%3BGreenberg%2C+Sarah%3BPetrowski%2C+Catherine+E%3BJesse%2C+Samantha%3BKraus%2C+Shane+W%3BMay%2C+Michael+C&rft.aulast=Stein&rft.aufirst=Catherine&rft.date=2015-02-01&rft.volume=86&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Psychiatric+Quarterly&rft.issn=00332720&rft_id=info:doi/10.1007%2Fs11126-014-9325-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-03-24 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1007/s11126-014-9325-3 ER - TY - JOUR T1 - Implementation of a Novel Occupational and Environmental Medicine Specialty Teleconsultation Service: The VHA Experience AN - 1668270281; PQ0001261238 AB - Objective: Occupational and environmental medicine (OEM) physician specialty practices continue to grow in scope and intensity across the Veterans Health Administration. This study characterizes the implementation of a novel, nationwide telemedicine program that provides OEM specialty consultation to providers across the Veterans Health Administration. Methods: We examined provider requests and specialist responses for a 6-month pilot from May to October 2013. Characteristics of consult users, determinants of case complexity, and specific applications of OEM specialty expertise were identified. Results: Over a 6-month period, employee occupational health providers consulted the OEM telemedicine pilot a total of 65 times. Employee occupational health providers without formal training repeatedly identified complex cases related to work and disability. Conclusions: The program has created a new system management solution to deliver expert, in-depth consultation and real-time provider education in OEM. JF - Journal of Occupational and Environmental Medicine AU - Eaton, Jennifer L AU - Mohr, David C AU - Mohammad, Amir AU - Kirkhorn, Steven AU - Gerstel-Santucci, Christina AU - McPhaul, Kathleen AU - Hodgson, Michael J AD - Occupational Health Group, Office of Public Health, Veterans Health Administration; War Related illness and Injury Study Center, Washington DC VA Medical Center; Occupational Health Group, VHA, 1717 H St NW Rm 504, Washington, DC 20006, Jennifer.Lipkowitz-Eaton@va.gov PY - 2015 SP - 173 EP - 177 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 2 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Education KW - Training KW - Disabilities KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668270281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Implementation+of+a+Novel+Occupational+and+Environmental+Medicine+Specialty+Teleconsultation+Service%3A+The+VHA+Experience&rft.au=Eaton%2C+Jennifer+L%3BMohr%2C+David+C%3BMohammad%2C+Amir%3BKirkhorn%2C+Steven%3BGerstel-Santucci%2C+Christina%3BMcPhaul%2C+Kathleen%3BHodgson%2C+Michael+J&rft.aulast=Eaton&rft.aufirst=Jennifer&rft.date=2015-02-01&rft.volume=57&rft.issue=2&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000330 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Education; Training; Disabilities; Occupational health DO - http://dx.doi.org/10.1097/JOM.0000000000000330 ER - TY - JOUR T1 - Health Care Employee Perceptions of Patient-Centered Care AN - 1665159658 AB - Given the importance of health care employees in the delivery of patient-centered care, understanding their unique perspectives is essential for quality improvement. The purpose of this study was to use photovoice to evaluate perceptions and experiences around patient-centered care among U.S. Veterans Affairs (VA) health care employees. We asked participants to take photographs of salient features in their environment related to patient-centered care. We used the photographs to facilitate dialogue during follow-up interviews. Twelve VA health care employees across two VA sites participated in the project. Although most participants felt satisfied with their work environment and experiences at the VA, they identified several areas for improvement. These included a need for more employee health and wellness initiatives and a need for enhanced opportunities for training and professional growth. Application of photovoice enabled us to learn about employees’ unique perspectives around patient-centered care while engaging them in an evaluation of care delivery. JF - Qualitative Health Research AU - Balbale, Salva Najib AU - Turcios, Stephanie AU - LaVela, Sherri L AD - United States Department of Veterans Affairs, Hines, Illinois, USA ; United States Department of Veterans Affairs, Hines, Illinois, USA Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 417 EP - 425 CY - Thousand Oaks PB - SAGE PUBLICATIONS, INC. VL - 25 IS - 3 SN - 1049-7323 KW - Medical Sciences KW - health care KW - health care professionals KW - photography / photovoice KW - quality improvement KW - research, qualitative KW - Care delivery KW - Health care KW - Health initiatives KW - Health professionals KW - Medical research KW - Patient care KW - Patient centredness KW - Perceptions KW - Photographs KW - Photography KW - Quality management KW - Service delivery KW - Veterans KW - Work environment KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665159658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Qualitative+Health+Research&rft.atitle=Health+Care+Employee+Perceptions+of+Patient-Centered+Care&rft.au=Balbale%2C+Salva+Najib%3BTurcios%2C+Stephanie%3BLaVela%2C+Sherri+L&rft.aulast=Balbale&rft.aufirst=Salva&rft.date=2015-02-01&rft.volume=25&rft.issue=3&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Qualitative+Health+Research&rft.issn=10497323&rft_id=info:doi/10.1177%2F1049732314553011 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-02-05 N1 - Last updated - 2016-05-12 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1177/1049732314553011 ER - TY - JOUR T1 - The Dynamics of Psychiatric Bed Use in General Hospitals AN - 1665153216 AB - This study examines general hospitals’ adjustments in psychiatric bed utilization practices in response to increases in psychiatric inpatient admissions. Using panel data from 439 hospitals, monthly observations ( N = 7,831) between 2007 and 2010 on psychiatric admissions, psychiatric bed occupancy rates, and average length-of-stay were created for psychiatric inpatients. In fixed-effects regressions, an increase in psychiatric admissions was associated with an increase in the probability of psychiatric bed use exceeding 100 % occupancy and with a reduction of mean length-of-stay. These results were confirmed in instrumental variables models. General hospitals may dynamically adjust bed utilization practices in response to changing psychiatric bed needs. An implication of this dynamic adjustment model is that bed shortages are likely to be local, transitory events. JF - Administration and Policy in Mental Health and Mental Health Services Research AU - Slade, Eric P AU - Goldman, Howard H AD - U.S. Department of Veterans Affairs, VA Capitol Healthcare Network Mental Illness Research, Education, and Clinical Center, 10 N. Greene Street, Baltimore, MD, 21201, USA, Department of Psychiatry, University of Maryland School of Medicine, 737 W. Lombard Street, Baltimore, MD, 21227, USA ; Department of Psychiatry, University of Maryland School of Medicine, 737 W. Lombard Street, Baltimore, MD, 21227, USA ; U.S. Department of Veterans Affairs, VA Capitol Healthcare Network Mental Illness Research, Education, and Clinical Center, 10 N. Greene Street, Baltimore, MD, 21201, USA; Department of Psychiatry, University of Maryland School of Medicine, 737 W. Lombard Street, Baltimore, MD, 21227, USA Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 139 EP - 146 CY - New York PB - Springer Science & Business Media VL - 42 IS - 2 SN - 0894-587X KW - Public Health And Safety KW - Admissions KW - Adjustment KW - Hospitalization KW - Hospitals KW - Length of stay KW - Mentally ill people KW - Occupancy KW - Panel data KW - Psychiatric hospitals KW - Shortages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665153216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+policy+in+mental+health&rft.atitle=Access+to+primary+care+for+homeless+veterans+with+serious+mental+illness+or+substance+abuse%3A+a+follow-up+evaluation+of+co-located+primary+care+and+homeless+social+services.&rft.au=McGuire%2C+James%3BGelberg%2C+Lillian%3BBlue-Howells%2C+Jessica%3BRosenheck%2C+Robert+A&rft.aulast=McGuire&rft.aufirst=James&rft.date=2009-07-01&rft.volume=36&rft.issue=4&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Administration+and+policy+in+mental+health&rft.issn=1573-3289&rft_id=info:doi/10.1007%2Fs10488-009-0210-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-03-05 N1 - Last updated - 2016-05-13 DO - http://dx.doi.org/10.1007/s10488-014-0554-4 ER - TY - JOUR T1 - Unexpected Challenges in Treating Multidrug-Resistant Gram-Negative Bacteria: Resistance to Ceftazidime-Avibactam in Archived Isolates of Pseudomonas aeruginosa AN - 1660435225; PQ0001092211 AB - Pseudomonas aeruginosa is a notoriously difficult-to-treat pathogen that is a common cause of severe nosocomial infections. Investigating a collection of beta -lactam-resistant P. aeruginosa clinical isolates from a decade ago, we uncovered resistance to ceftazidime-avibactam, a novel beta -lactam/ beta -lactamase inhibitor combination. The isolates were systematically analyzed through a variety of genetic, biochemical, genomic, and microbiological methods to understand how resistance manifests to a unique drug combination that is not yet clinically released. We discovered that avibactam was able to inactivate different AmpC beta -lactamase enzymes and that blaPDC regulatory elements and penicillin-binding protein differences did not contribute in a major way to resistance. By using carefully selected combinations of antimicrobial agents, we deduced that the greatest barrier to ceftazidime-avibactam is membrane permeability and drug efflux. To overcome the constellation of resistance determinants, we show that a combination of antimicrobial agents (ceftazidime/avibactam/fosfomycin) targeting multiple cell wall synthetic pathways can restore susceptibility. In P. aeruginosa, efflux, as a general mechanism of resistance, may pose the greatest challenge to future antibiotic development. Our unexpected findings create concern that even the development of antimicrobial agents targeted for the treatment of multidrug-resistant bacteria may encounter clinically important resistance. Antibiotic therapy in the future must consider these factors. JF - Antimicrobial Agents & Chemotherapy AU - Winkler, Marisa L AU - Papp-Wallace, Krisztina M AU - Hujer, Andrea M AU - Domitrovic, T Nicholas AU - Hujer, Kristine M AU - Hurless, Kelly N AU - Tuohy, Marion AU - Hall, Geraldine AU - Bonomo, Robert A AD - Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA, robert.bonomo@va.gov. Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 1020 EP - 1029 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clinical isolates KW - fosfomycin KW - Bacteria KW - beta -Lactamase KW - Regulatory sequences KW - Drug resistance KW - Enzymes KW - Membrane permeability KW - penicillin-binding protein KW - Antibiotics KW - Pathogens KW - Antimicrobial agents KW - Ceftazidime KW - Gram-negative bacteria KW - beta -Lactam antibiotics KW - Nosocomial infection KW - genomics KW - Pseudomonas aeruginosa KW - Cell walls KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660435225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Unexpected+Challenges+in+Treating+Multidrug-Resistant+Gram-Negative+Bacteria%3A+Resistance+to+Ceftazidime-Avibactam+in+Archived+Isolates+of+Pseudomonas+aeruginosa&rft.au=Winkler%2C+Marisa+L%3BPapp-Wallace%2C+Krisztina+M%3BHujer%2C+Andrea+M%3BDomitrovic%2C+T+Nicholas%3BHujer%2C+Kristine+M%3BHurless%2C+Kelly+N%3BTuohy%2C+Marion%3BHall%2C+Geraldine%3BBonomo%2C+Robert+A&rft.aulast=Winkler&rft.aufirst=Marisa&rft.date=2015-02-01&rft.volume=59&rft.issue=2&rft.spage=1020&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.04238-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 67 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - fosfomycin; Clinical isolates; beta -Lactamase; Drug resistance; Regulatory sequences; Membrane permeability; Enzymes; Antibiotics; penicillin-binding protein; Pathogens; Antimicrobial agents; Ceftazidime; Gram-negative bacteria; Nosocomial infection; beta -Lactam antibiotics; genomics; Cell walls; Bacteria; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1128/AAC.04238-14 ER - TY - JOUR T1 - Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor. AN - 1652410542; 25339356 AB - The precise mechanism for reduced thrombosis in prekallikrein null mice (Klkb1(-/-)) is unknown. Klkb1(-/-) mice have delayed carotid artery occlusion times on the rose bengal and ferric chloride thrombosis models. Klkb1(-/-) plasmas have long-activated partial thromboplastin times and defective contact activation-induced thrombin generation that partially corrects upon prolonged incubation. However, in contact activation-induced pulmonary thromboembolism by collagen/epinephrine or long-chain polyphosphate, Klkb1(-/-) mice, unlike F12(-/-) mice, do not have survival advantage. Klkb1(-/-) mice have reduced plasma BK levels and renal B2R mRNA. They also have increased expression of the renal receptor Mas and plasma prostacyclin. Increased prostacyclin is associated with elevated aortic vasculoprotective transcription factors Sirt1 and KLF4. Treatment of Klkb1(-/-) mice with the Mas antagonist A-779, COX-2 inhibitor nimesulide, or Sirt1 inhibitor splitomicin lowers plasma prostacyclin and normalizes arterial thrombosis times. Treatment of normal mice with the Mas agonist AVE0991 reduces thrombosis. Klkb1(-/-) mice have reduced aortic tissue factor (TF) mRNA, antigen, and activity. In sum, Klkb1(-/-) mice have a novel mechanism for thrombosis protection in addition to reduced contact activation. This pathway arises when bradykinin delivery to vasculature is compromised and mediated by increased receptor Mas, prostacyclin, Sirt1, and KLF4, leading to reduced vascular TF. © 2015 by The American Society of Hematology. JF - Blood AU - Stavrou, Evi X AU - Fang, Chao AU - Merkulova, Alona AU - Alhalabi, Omar AU - Grobe, Nadja AU - Antoniak, Silvio AU - Mackman, Nigel AU - Schmaier, Alvin H AD - Divisions of Hematology and Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH; Department of Medicine, Louis Stokes Veterans Administration Hospital, Cleveland, OH; ; Divisions of Hematology and Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH; Department of Pathology, Case Western Reserve University, Cleveland, OH; ; Divisions of Hematology and Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH; ; Department of Pharmacology and Toxicology, Wright State University Boonshoft School of Medicine, Dayton OH; and. ; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC. Y1 - 2015/01/22/ PY - 2015 DA - 2015 Jan 22 SP - 710 EP - 719 VL - 125 IS - 4 KW - 7-Ala-angiotensin (1-7) KW - 0 KW - AVE 0991 KW - GKLF protein KW - Imidazoles KW - Kruppel-Like Transcription Factors KW - Naphthalenes KW - Nerve Tissue Proteins KW - Peptide Fragments KW - Proto-Oncogene Proteins KW - Pyrones KW - RNA, Messenger KW - Receptor, Bradykinin B2 KW - Receptors, G-Protein-Coupled KW - Sulfonamides KW - Syt17 protein, mouse KW - proto-oncogene proteins c-mas-1 KW - Angiotensin II KW - 11128-99-7 KW - Synaptotagmins KW - 134193-27-4 KW - splitomicin KW - 4707-36-2 KW - Thromboplastin KW - 9035-58-9 KW - Prekallikrein KW - 9055-02-1 KW - Epoprostenol KW - DCR9Z582X0 KW - Sirt1 protein, mouse KW - EC 3.5.1.- KW - Sirtuin 1 KW - nimesulide KW - V4TKW1454M KW - Abridged Index Medicus KW - Index Medicus KW - Synaptotagmins -- genetics KW - Naphthalenes -- pharmacology KW - Angiotensin II -- analogs & derivatives KW - Animals KW - Sirtuin 1 -- biosynthesis KW - Imidazoles -- pharmacology KW - Synaptotagmins -- biosynthesis KW - Mice KW - Nerve Tissue Proteins -- biosynthesis KW - Nerve Tissue Proteins -- genetics KW - Receptor, Bradykinin B2 -- biosynthesis KW - Angiotensin II -- pharmacology KW - Mice, Knockout KW - Partial Thromboplastin Time KW - Pyrones -- pharmacology KW - Sulfonamides -- pharmacology KW - Sirtuin 1 -- genetics KW - Receptor, Bradykinin B2 -- genetics KW - Peptide Fragments -- pharmacology KW - Sirtuin 1 -- antagonists & inhibitors KW - Kruppel-Like Transcription Factors -- antagonists & inhibitors KW - Thromboplastin -- antagonists & inhibitors KW - Proto-Oncogene Proteins -- metabolism KW - Carotid Artery Thrombosis -- genetics KW - Thromboplastin -- biosynthesis KW - Receptors, G-Protein-Coupled -- antagonists & inhibitors KW - Proto-Oncogene Proteins -- antagonists & inhibitors KW - Carotid Artery Thrombosis -- metabolism KW - Kruppel-Like Transcription Factors -- biosynthesis KW - Receptors, G-Protein-Coupled -- metabolism KW - Receptors, G-Protein-Coupled -- genetics KW - Carotid Artery Thrombosis -- chemically induced KW - Thromboplastin -- genetics KW - Carotid Artery Thrombosis -- pathology KW - Proto-Oncogene Proteins -- genetics KW - Epoprostenol -- biosynthesis KW - Epoprostenol -- genetics KW - Kruppel-Like Transcription Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652410542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Reduced+thrombosis+in+Klkb1-%2F-+mice+is+mediated+by+increased+Mas+receptor%2C+prostacyclin%2C+Sirt1%2C+and+KLF4+and+decreased+tissue+factor.&rft.au=Stavrou%2C+Evi+X%3BFang%2C+Chao%3BMerkulova%2C+Alona%3BAlhalabi%2C+Omar%3BGrobe%2C+Nadja%3BAntoniak%2C+Silvio%3BMackman%2C+Nigel%3BSchmaier%2C+Alvin+H&rft.aulast=Stavrou&rft.aufirst=Evi&rft.date=2015-01-22&rft.volume=125&rft.issue=4&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2014-01-550285 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-24 N1 - Date created - 2015-01-23 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Blood. 1974 May;43(5):641-4 [4821398] J Biol Chem. 2007 May 4;282(18):13769-79 [17339326] J Clin Invest. 1980 Feb;65(2):413-21 [7356688] Thromb Res. 1980 Jun 15;18(6):787-95 [6774443] J Lab Clin Med. 1983 Oct;102(4):487-99 [6604770] J Lab Clin Med. 1984 Dec;104(6):882-92 [6209352] Blood. 1985 Oct;66(4):835-9 [3929859] Nature. 1987 Jun 11-17;327(6122):524-6 [3495737] Mol Med. 2008 Jan-Feb;14(1-2):28-35 [18026570] J Exp Med. 2007 Sep 3;204(9):2053-61 [17724132] J Biol Chem. 1992 Jan 5;267(1):303-9 [1309739] Blood. 2008 Feb 1;111(3):1274-81 [18000168] Cell. 2009 Dec 11;139(6):1143-56 [20005807] Circulation. 2010 Apr 6;121(13):1510-7 [20308613] Mol Med. 2010 May-Jun;16(5-6):210-5 [20111697] Cardiovasc Res. 2011 Feb 1;89(2):464-72 [20978007] Nat Med. 2011 Feb;17(2):206-10 [21258336] Am J Respir Cell Mol Biol. 2011 May;44(5):725-38 [21531958] Blood. 2011 Nov 10;118(19):5302-11 [21821705] Thromb Haemost. 2012 Jun;107(6):1141-50 [22398951] Circulation. 2012 Sep 11;126(11):1373-84 [22865892] J Clin Invest. 2012 Dec;122(12):4727-31 [23160196] Thromb Haemost. 2013 Mar;109(3):368-74 [23306453] Blood. 2013 Apr 11;121(15):3023-32 [23386129] Am J Physiol Cell Physiol. 2013 May 15;304(10):C945-53 [23392115] Nucleic Acid Ther. 2013 Jun;23(3):175-87 [23582057] J Biol Chem. 2013 Jun 28;288(26):18872-84 [23661707] J Exp Med. 1978 Mar 1;147(3):719-29 [632748] Circulation. 2000 May 9;101(18):2144-8 [10801753] Arthritis Rheum. 2000 Aug;43(8):1891-6 [10943882] Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1821-9 [11247797] J Clin Invest. 2002 Apr;109(8):1057-63 [11956243] J Biol Chem. 2002 May 17;277(20):17962-9 [11830581] Hypertension. 2002 Nov;40(5):774-9 [12411476] Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R1-13 [12793984] EMBO J. 2004 Jun 16;23(12):2369-80 [15152190] Blood. 1993 Jun 1;81(11):2936-46 [8388750] Circulation. 1996 Aug 1;94(3):517-28 [8759097] J Clin Invest. 1969 Jan;48(1):11-22 [4974623] Science. 1964 Sep 18;145(3638):1310-2 [14173416] Blood. 2005 Jan 1;105(1):192-8 [15339841] J Exp Med. 2005 Jul 18;202(2):271-81 [16009717] Thromb Haemost. 2006 Jun;95(6):1003-10 [16732380] Blood. 2006 Jul 1;108(1):192-9 [16514058] Comment In: Blood. 2015 Jan 22;125(4):589-90 [25614637] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1182/blood-2014-01-550285 ER - TY - JOUR T1 - Effect modification by vitamin D receptor genetic polymorphisms in the association between cumulative lead exposure and pulse pressure: a longitudinal study. AN - 1697216633; 25582168 AB - Although the association between lead and cardiovascular disease is well established, potential mechanisms are still poorly understood. Calcium metabolism plays a role in lead toxicity and thus, vitamin D receptor (VDR) polymorphisms have been suggested to modulate the association between lead and health outcomes. We investigated effect modification by VDR genetic polymorphisms in the association between cumulative lead exposure and pulse pressure, a marker of arterial stiffness. We examined 727 participants (3,100 observations from follow-ups from 1991 to 2011) from the Normative Aging Study (NAS), a longitudinal study of aging. Tibia and patella bone lead levels were measured using K-x-ray fluorescence. Four single nucleotide polymorphisms (SNPs) in the VDR gene, Bsm1, Taq1, Apa1, and Fok1, were genotyped. Linear mixed effects models with random intercepts were implemented to take into account repeated measurements. Adjusting for potential confounders, pulse pressure was 2.5 mmHg (95% CI: 0.4-4.7) and 1.9 mmHg (95% CI: 0.1-3.8) greater per interquartile range (IQR) increase in tibia lead (15 μg/g) and patella lead (20 μg/g), respectively, in those with at least one minor frequency allele in Bsm1 compared with those with major frequency allele homozygotes. The observed interaction effect between bone lead and the Bsm1 genotype persists over time during the follow-up. Similar results were observed in effect modification by Taq1. This study suggests that subjects with the minor frequency alleles of VDR Bsm1 or Taq1 may be more susceptible to cumulative lead exposure-related elevated pulse pressure. JF - Environmental health : a global access science source AU - Jhun, Min A AU - Hu, Howard AU - Schwartz, Joel AU - Weisskopf, Marc G AU - Nie, Linda H AU - Sparrow, David AU - Vokonas, Pantel S AU - Park, Sung Kyun AD - Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA. minajhun@umich.edu. ; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. howard.hu@utoronto.ca. ; Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. jschwrtz@hsph.harvard.edu. ; Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. mweissko@hsph.harvard.edu. ; School of Health Sciences, Purdue University, West Lafayette, IN, USA. hnie@purdue.edu. ; Veterans Affairs Boston Healthcare System and Boston University School of Medicine & Public Health, Boston, MA, USA. david.sparrow@va.gov. ; Veterans Affairs Boston Healthcare System and Boston University School of Medicine & Public Health, Boston, MA, USA. pantel.vokonas@va.gov. ; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA. sungkyun@umich.edu. Y1 - 2015/01/13/ PY - 2015 DA - 2015 Jan 13 SP - 5 VL - 14 KW - Receptors, Calcitriol KW - 0 KW - Vitamin D KW - 1406-16-2 KW - Lead KW - 2P299V784P KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Young Adult KW - Polymorphism, Single Nucleotide KW - Blood Pressure -- physiology KW - Humans KW - Environmental Exposure -- analysis KW - Aged KW - Boston KW - Longitudinal Studies KW - Tibia -- chemistry KW - Aging -- physiology KW - Patella -- chemistry KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Gene Expression Regulation KW - Female KW - Male KW - Calcium -- metabolism KW - Cardiovascular Diseases -- etiology KW - Receptors, Calcitriol -- genetics KW - Lead -- toxicity KW - Vitamin D -- metabolism KW - Vitamin D -- genetics KW - Receptors, Calcitriol -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697216633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Drug+Resistance&rft.atitle=Marked+Increase+in+Biofilm-Derived+Rough+Pneumococcal+Variants+and+Rifampin-Resistant+Strains+Not+Due+to+hex+Gene+Mutations&rft.au=McEllistrem%2C+M+C%3BScott%2C+J+R%3BZuniga-Castillo%2C+J%3BKhan%2C+SA&rft.aulast=McEllistrem&rft.aufirst=M&rft.date=2009-06-01&rft.volume=15&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Microbial+Drug+Resistance&rft.issn=10766294&rft_id=info:doi/10.1089%2Fmdr.2009.0866 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-04 N1 - Date created - 2015-07-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Epidemiology. 2006 Sep;17(5):531-7 [16878040] Gene. 2006 Oct 1;380(2):63-71 [16872759] Environ Health Perspect. 2007 Dec;115(12):1696-700 [18087585] Arch Toxicol. 2008 Jan;82(1):29-36 [17701399] Med Clin (Barc). 2008 Mar 22;130(10):361-5 [18381026] Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H454-65 [18567711] J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):215-22 [19196902] Epidemiology. 2009 Nov;20(6):831-9 [19752734] J Pathol. 2010 Jan;220(2):152-63 [19918805] Environ Health Perspect. 2009 Oct;117(10):1526-30 [20019901] Neurotoxicol Teratol. 2010 Mar-Apr;32(2):262-72 [20006704] Environ Health Perspect. 2010 Sep;118(9):1261-6 [20478760] Nature. 2010 Sep 2;467(7311):52-8 [20811451] Environ Health Perspect. 2011 May;119(5):664-9 [21292600] J Occup Environ Med. 2011 Aug;53(8):850-5 [21788910] J Clin Endocrinol Metab. 2012 Oct;97(10):3717-23 [22767638] Epidemiology. 2013 Jan;24(1):10-3 [23232608] Cell Immunol. 2012 Oct;279(2):160-6 [23246677] Environ Health Perspect. 2000 Mar;108(3):199-203 [10706524] Mol Endocrinol. 2014 Jan;28(1):53-64 [24284821] Environ Health Perspect. 2000 Mar;108 Suppl 1:23-8 [10698721] Environ Health Perspect. 2000 Oct;108(10):949-54 [11049814] Am J Epidemiol. 2001 Jan 15;153(2):164-71 [11159162] Environ Health Perspect. 2001 Apr;109(4):383-9 [11335187] Hypertension. 2001 Oct;38(4):793-7 [11641288] Environ Health Perspect. 2004 May;112(6):746-50 [15121519] Br J Ind Med. 1975 May;32(2):119-39 [1131339] J Nutr. 1981 Aug;111(8):1321-9 [6267235] Proc Natl Acad Sci U S A. 1981 Oct;78(10):6494-8 [6947240] J Nutr. 1984 Apr;114(4):692-700 [6325646] Neurotoxicology. 1984 Fall;5(3):295-331 [6151637] Toxicol Appl Pharmacol. 1989 May;98(3):530-43 [2718179] Proc Soc Exp Biol Med. 1990 Jul;194(3):258-64 [2162539] Arch Environ Contam Toxicol. 1995 Feb;28(2):168-72 [7710289] Phys Med Biol. 1995 Sep;40(9):1475-85 [8532760] Eur Heart J. 2005 Oct;26(20):2120-6 [16141262] Am J Epidemiol. 2006 Mar 1;163(5):467-78 [16421242] J Am Coll Cardiol. 2006 Apr 18;47(8 Suppl):C7-12 [16631513] Environ Res. 2006 Sep;102(1):61-9 [16487505] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/1476-069X-14-5 ER - TY - JOUR T1 - Tobacco use trajectories among a large cohort of treated smokers with posttraumatic stress disorder AN - 1837332245; PQ0001000216 AB - Introduction: This study identified distinct tobacco use trajectories across 18 months in 943 veteran smokers with posttraumatic stress disorder (PTSD) in order to describe quit and relapse patterns, examine associations between trajectory groups on baseline characteristics and cessation service utilization, and explore group differences in mental health outcomes. Methods: Veterans who participated in a multisite, randomized trial of integrated smoking cessation care were grouped using k-means clustering based on reported daily tobacco use between baseline and 18 months. Four trajectory clusters were identified: no reduction (62%), temporary reduction (11%), late sustained reduction (9%) and early sustained reduction (18%). Results: Median quit times in the early, late, temporary, and no reduction groups were 451,141.5,97, and 2 days, respectively. Compared to the early reduction group, the temporary reduction group exhibited higher baseline depression (p < 0.01) and anxiety (p < 0.01), but did not differ in treatment received, with both groups attending significantly more cessation visits (p < 0.001) and more likely to receive recommended pharmacotherapy (p < 0.001) than the no reduction group between baseline and 6 months. The early reduction group exhibited lower depression relative to the no reduction (p < 0.01) and temporary reduction (p < 0.01) groups across all assessments between baseline and 18 months. Differences were not observed between groups in depressive or PTSD symptom change over time between baseline and 18 months. Conclusions: Tobacco use trajectories among treated smokers with PTSD vary distinctly. Characteristics of identified subgroups may lead to targeted interventions among smokers with PTSD and potentially other psychiatric disorders. JF - Addictive Behaviors AU - Malte, Carol A AU - Dennis, Paul A AU - Saxon, Andrew J AU - McFall, Miles AU - Carmody, Timothy P AU - Unger, William AU - Beckham, Jean C AD - Veterans Affairs Puget Sound Health Care System, Seattle, WA United States; Center of Excellence in Substance Abuse Treatment and Education, VA Puget Sound Health Care System, 1660 S. Columbian Way, S-116 ATC, Seattle, WA 98108, United States, Carol.Malte@va.gov Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 238 EP - 246 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 41 SN - 0306-4603, 0306-4603 KW - Toxicology Abstracts KW - Smoking cessation KW - Posttraumatic stress disorder KW - Veterans KW - Major depressive disorder KW - Relapse KW - Smoking KW - Mental disorders KW - Depression KW - Anxiety KW - Tobacco KW - Drug addiction KW - Post-traumatic stress disorder KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837332245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+Behaviors&rft.atitle=Tobacco+use+trajectories+among+a+large+cohort+of+treated+smokers+with+posttraumatic+stress+disorder&rft.au=Malte%2C+Carol+A%3BDennis%2C+Paul+A%3BSaxon%2C+Andrew+J%3BMcFall%2C+Miles%3BCarmody%2C+Timothy+P%3BUnger%2C+William%3BBeckham%2C+Jean+C&rft.aulast=Malte&rft.aufirst=Carol&rft.date=2015-01-01&rft.volume=41&rft.issue=&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Addictive+Behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2014.10.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Smoking; Mental disorders; Depression; Anxiety; Tobacco; Drug addiction; Post-traumatic stress disorder DO - http://dx.doi.org/10.1016/j.addbeh.2014.10.034 ER - TY - JOUR T1 - Characteristics of substance use disorder treatment patients using medical cannabis for pain AN - 1837325652; PQ0001285144 AB - Background: This study was designed to assess the prevalence and correlates of self-reported medical cannabis use for pain in a substance use disorder (SUD) treatment program. Method: Participants (n = 433) aged 18 years and older were recruited from February 2012 to July 2014 at a large residential SUD treatment program. They completed a battery of questionnaires to assess demographics, usual pain level in the past three months (using the 11-point Numeric Rating Scale for pain), depression (using the Beck Depression Inventory), previous types of pain treatments, and lifetime and past-year use of substances (using the Addiction Severity Index). Using both adjusted and unadjusted logistic regression models, we compared those who reported medical cannabis use for pain with those who did not report it. Results: Overall, 15% of the sample (n = 63) reported using medical cannabis for pain in the past year. After adjusting for age, medical cannabis use for pain was significantly associated with past-year use of alcohol, cocaine, heroin, other opioids, and sedatives, but was not associated with usual pain level or depression. It was also associated with past year treatment of pain using prescription pain relievers without prescriptions. Conclusions: These results indicate that medical cannabis use for pain is relatively common and is associated with more extensive substance use among SUD patients. Future work is needed to develop and evaluate strategies to assess and treat individuals who report medical cannabis for pain in SUD treatment settings. JF - Addictive Behaviors AU - Ashrafioun, Lisham AU - Bohnert, Kipling M AU - Jannausch, Mary AU - Ilgen, Mark A AD - Bowling Green Srate University, Department of Psychology, 207 Psychology Building, Bowling Green, OH 43403, USA; VISN 2 Center of Excellence in Suicide Prevention, Canandaigua VA Medical Center, 400 Fort Hill Avenue, Canandaigua, NY 14424, USA, Lisham.ashrafion@va.gov Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 185 EP - 188 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 42 SN - 0306-4603, 0306-4603 KW - Toxicology Abstracts KW - Cannabis KW - Substance use disorders KW - Pain KW - Inventories KW - Age KW - Depression KW - Heroin KW - Models KW - Demography KW - Sedatives KW - Regression analysis KW - alcohols KW - Opioids KW - Addiction KW - Cocaine KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837325652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+Behaviors&rft.atitle=Characteristics+of+substance+use+disorder+treatment+patients+using+medical+cannabis+for+pain&rft.au=Ashrafioun%2C+Lisham%3BBohnert%2C+Kipling+M%3BJannausch%2C+Mary%3BIlgen%2C+Mark+A&rft.aulast=Ashrafioun&rft.aufirst=Lisham&rft.date=2015-01-01&rft.volume=42&rft.issue=&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Addictive+Behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2014.11.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Inventories; Age; Depression; Heroin; Pain; Models; Demography; Sedatives; Cannabis; alcohols; Regression analysis; Opioids; Addiction; Cocaine DO - http://dx.doi.org/10.1016/j.addbeh.2014.11.024 ER - TY - JOUR T1 - Impact Study: MK-0646 (Dalotuzumab), Insulin Growth Factor 1 Receptor Antibody Combined with Pemetrexed and Cisplatin in Stage IV Metastatic Non-squamous Lung Cancer. AN - 1760902416; 26793618 AB - Insulin-like growth factor 1 receptor (IGF-1R) regulates cell growth, proliferation, and apoptosis. Adenocarcinoma and never-smokers have a higher expression of IGF-1R, which is associated with worse overall survival. Dalotuzumab-MK0646 (D) is a humanized monoclonal antibody that targets IGF-1R. Pemetrexed (P) has higher activity in non-squamous lung cancer (NSQL). We initiated a randomized phase II trial to test the combination of P and Cisplatin (C) ± D in NSQL. Eligibility criteria were untreated NSQL stage IV, ECOG 0 or 1, measurable disease, adequate renal, hepatic and hematologic function, and no other intercurrent illness. P at 500 mg/m(2) and C at 75 mg/m(2) IV were given every 3 weeks. D was given at 10 mg/kg IV weekly on days 1, 8, and 15 of every 3-week cycle in the experimental group. The patients had a radiographic assessment after every two cycles and were treated for a maximum of six cycles if there was a response or stable disease. The primary objective of the study was to compare the clinical response rates of PC vs. PC + D. From 1/2009 to 2/2011, the study accrued 26 subjects: 16 male and 10 female, with a median age of 59; 14 were treated with PC and 12 were treated with PC + D. We observed two partial responses (PR), seven stable disease (SD), three progressive disease (PD), and two not evaluable (NE) in the PC arm. In comparison, for the PC + D arm, there were three PR, four SD, four PD, and one NE. The hematologic toxicity was similar in both groups. There was higher incidence of hyperglycemia in the experimental group; four cases with grade 3 and one case with grade 4. PC + D had a similar response rate compared to PC, with a higher rate of hyperglycemia. Identification of responders using predictive markers would be key to continuing the study of D in NSQL. NCT00799240, clinicaltrials.gov. JF - Frontiers in oncology AU - Huang, Chao H AU - Williamson, Stephen K AU - Neupane, Prakash AU - Taylor, Sarah A AU - Allen, Ace AU - Smart, Nora J AU - Uypeckcuat, Adelina M AU - Spencer, Sarah AU - Wick, Jo AU - Smith, Holly AU - Van Veldhuizen, Peter J AU - Kelly, Karen AD - Kansas City Veterans Administration Medical Center, Kansas City, MO, USA; University of Kansas Cancer Center, Westwood, KS, USA. ; University of Kansas Cancer Center , Westwood, KS , USA. ; Kansas City Veterans Administration Medical Center , Kansas City, MO , USA. ; Department of Biostatistics, University of Kansas , Kansas City, KS , USA. ; University of California Davis Comprehensive Cancer Center , Sacramento, CA , USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 301 VL - 5 KW - non-squamous cell lung cancer KW - treatment KW - metastatic KW - IGF-1R KW - pemetrexed KW - dalotuzumab UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760902416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+oncology&rft.atitle=Impact+Study%3A+MK-0646+%28Dalotuzumab%29%2C+Insulin+Growth+Factor+1+Receptor+Antibody+Combined+with+Pemetrexed+and+Cisplatin+in+Stage+IV+Metastatic+Non-squamous+Lung+Cancer.&rft.au=Huang%2C+Chao+H%3BWilliamson%2C+Stephen+K%3BNeupane%2C+Prakash%3BTaylor%2C+Sarah+A%3BAllen%2C+Ace%3BSmart%2C+Nora+J%3BUypeckcuat%2C+Adelina+M%3BSpencer%2C+Sarah%3BWick%2C+Jo%3BSmith%2C+Holly%3BVan+Veldhuizen%2C+Peter+J%3BKelly%2C+Karen&rft.aulast=Huang&rft.aufirst=Chao&rft.date=2015-01-01&rft.volume=5&rft.issue=&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+oncology&rft.issn=&rft_id=info:doi/10.3389%2Ffonc.2015.00301 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-21 N1 - Date created - 2016-01-21 N1 - Date revised - 2017-02-06 N1 - Genetic sequence - NCT00799240; ClinicalTrials.gov N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.3389/fonc.2015.00301 ER - TY - JOUR T1 - Caregivers of Veterans with 'Invisible' Injuries: What We Know and Implications for Social Work Practice AN - 1735650788; 201507000 AB - Today, as a result of the longest volunteer-fought conflict in U.S. history, there are many wounded coming home not only with posttraumatic stress disorder (PTSD), but also with traumatic brain injury (TBI), which together have been called the 'signature' or 'invisible' injuries of the Iraq and Afghanistan wars. Caregivers are an important part of their recovery, yet little is known about them, as previous research on caregivers mostly focused on geriatric populations. According to one estimate 275,000 to 1 million people are currently caring or have cared for loved ones who have returned from Iraq and Afghanistan. These caregivers are unique in that they are younger, some with children, and they are caring for a unique understudied population for longer periods of time. This article summarizes literature on caregivers of veterans who suffer from PTSD, TBI, or both; provides a theoretical framework; and discusses implications for social workers in assisting caregivers and their families. Adapted from the source document. JF - Social Work AU - Patel, Bina R AD - Caregiver Support Coordinator, Social Work, U.S. Department of Veterans Affairs, 1601 SW Archer Road, Mail Code 116A-4, Gainesville, FL beepat617@hotmail.com Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 9 EP - 17 PB - Oxford University Press, Oxford Journals VL - 60 IS - 1 SN - 0037-8046, 0037-8046 KW - caregivers, Iraq/Afghanistan caregivers, military caregivers, Operation Iraqi Freedom and Operation Enduring Freedom caregivers, veteran caregivers KW - Veterans KW - Caregivers KW - War KW - Geriatrics KW - Brain KW - Afghanistan KW - Conflict KW - Posttraumatic Stress Disorder KW - Iraq KW - article KW - 6142: mental & emotional health problems KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735650788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work&rft.atitle=Caregivers+of+Veterans+with+%27Invisible%27+Injuries%3A+What+We+Know+and+Implications+for+Social+Work+Practice&rft.au=Patel%2C+Bina+R&rft.aulast=Patel&rft.aufirst=Bina&rft.date=2015-01-01&rft.volume=60&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Social+Work&rft.issn=00378046&rft_id=info:doi/10.1093%2Fsw%2Fswu043 LA - English DB - Social Services Abstracts N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SOWOA8 N1 - SubjectsTermNotLitGenreText - Caregivers; Posttraumatic Stress Disorder; Iraq; Veterans; Afghanistan; Conflict; War; Brain; Geriatrics DO - http://dx.doi.org/10.1093/sw/swu043 ER - TY - JOUR T1 - Diagnosis of toxic alcohols: limitations of present methods. AN - 1700334033; 26114345 AB - Methanol, ethylene glycol, diethylene glycol, and propylene glycol intoxications are associated with cellular dysfunction and an increased risk of death. Adverse effects can develop quickly; thus, there is a need for methods for rapidly detecting their presence. To examine the value and limitations of present methods to diagnose patients with possible toxic alcohol exposure. I searched MEDLINE for articles published between 1969 and 2014 using the terms: toxic alcohols, serum osmolality, serum osmol gap, serum anion gap, metabolic acidosis, methanol, ethylene glycol, diethylene glycol, propylene glycol, and fomepizole. Each article was reviewed for additional references. The diagnosis of toxic alcohol exposure is often made on the basis of this history and physical findings along with an increase in the serum osmol and anion gaps. However, an increase in the osmol and/or anion gaps is not always present. Definitive detection in blood requires gas or liquid chromatography, laborious and expensive procedures which are not always available. Newer methods including a qualitative colorimetric test for detection of all alcohols or enzymatic tests for a specific alcohol might allow for more rapid diagnosis. Exposure to toxic alcohols is associated with cellular dysfunction and increased risk of death. Treatment, if initiated early, can markedly improve outcome, but present methods of diagnosis including changes in serum osmol and anion gap, and use of gas or liquid chromatography have important limitations. Development of more rapid and effective tests for detection of these intoxications is essential for optimal care of patients. JF - Clinical toxicology (Philadelphia, Pa.) AU - Kraut, Jeffrey A AD - Medical and Research Services Veterans Administration Greater Los Angeles Healthcare System, UCLA Membrane Biology Laboratory, and Division of Nephrology, Veterans Administration Greater Los Angeles Healthcare System, and David Geffen School of Medicine , Los Angeles , California. Y1 - 2015 PY - 2015 DA - 2015 SP - 589 EP - 595 VL - 53 IS - 7 KW - Alcohols KW - 0 KW - Ethylene Glycols KW - Pyrazoles KW - diethylene glycol KW - 61BR964293 KW - Propylene Glycol KW - 6DC9Q167V3 KW - fomepizole KW - 83LCM6L2BY KW - Ethylene Glycol KW - FC72KVT52F KW - Methanol KW - Y4S76JWI15 KW - Abridged Index Medicus KW - Index Medicus KW - Propylene glycol KW - Serum osmolal gap KW - Fomepizole KW - Serum anion gap KW - Ethylene glycol KW - Toxic alcohols KW - Osmolar Concentration KW - Acid-Base Equilibrium KW - Humans KW - Acidosis -- blood KW - Pyrazoles -- blood KW - Propylene Glycol -- blood KW - Methanol -- blood KW - Ethylene Glycols -- blood KW - Ethylene Glycol -- blood KW - Alcohols -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700334033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+toxicology+%28Philadelphia%2C+Pa.%29&rft.atitle=Diagnosis+of+toxic+alcohols%3A+limitations+of+present+methods.&rft.au=Kraut%2C+Jeffrey+A&rft.aulast=Kraut&rft.aufirst=Jeffrey&rft.date=2015-01-01&rft.volume=53&rft.issue=7&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Clinical+toxicology+%28Philadelphia%2C+Pa.%29&rft.issn=1556-9519&rft_id=info:doi/10.3109%2F15563650.2015.1056880 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-16 N1 - Date created - 2015-07-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/15563650.2015.1056880 ER - TY - JOUR T1 - Progesterone and Src Family Inhibitor PP1 Synergistically Inhibit Cell Migration and Invasion of Human Basal Phenotype Breast Cancer Cells AN - 1691292124; PQ0001645787 AB - Basal phenotype breast cancer is one of the most aggressive breast cancers that frequently metastasize to brain. The role of sex hormones and their receptors in development of this disease is largely unclear. We demonstrated that mPR alpha was expressed at a moderate level in a brain metastatic BPBC cell line MB231Br, which was derived from the parent mPR alpha undetectable MB231 cells. It functioned as an essential mediator for progesterone induced inhibitory effects on cell migration of MB231Br and, when coincubated with PP1, synergistically enhanced the progesterone's inhibitory effect on cell migration and invasion in vitro . Progesterone and PP1 cotreatment induced a cascade of molecular signaling events, such as dephosphorylation of FAK, downregulation of MMP9, VEGF, and KCNMA1 expressions. Our in vitro study demonstrated that mPR alpha was expressed and functioned as an essential mediator for progesterone induced inhibitory effects on cell migration and invasion in BPBC cells. This inhibitory effect was enhanced by PP1 via FAK dephosphorylation, MMP9, VEGF, and KCNMA1 downregulation mechanisms. Our study provides a new clue toward the development of novel promising agents and pathways for inhibiting nuclear hormonal receptor-negative and endocrine-resistant breast cancers. JF - BioMed Research International AU - Xie, Mingxuan AU - Zhou, Li AU - Chen, Xi AU - Gainey, Lindsey O AU - Xiao, Jian AU - Nanes, Mark S AU - Hou, Anji AU - You, Shaojin AU - Chen, Qiong AD - Department of Geriatrics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China, shaojin.you@va.gov Y1 - 2015/01// PY - 2015 DA - Jan 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-6133, 2314-6133 KW - Biotechnology and Bioengineering Abstracts KW - Vascular endothelial growth factor KW - Progesterone KW - Dephosphorylation KW - Brain KW - Sex hormones KW - Metastases KW - Focal adhesion kinase KW - Src protein KW - Breast cancer KW - Cell migration KW - Gelatinase B KW - Signal transduction KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691292124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Progesterone+and+Src+Family+Inhibitor+PP1+Synergistically+Inhibit+Cell+Migration+and+Invasion+of+Human+Basal+Phenotype+Breast+Cancer+Cells&rft.au=Xie%2C+Mingxuan%3BZhou%2C+Li%3BChen%2C+Xi%3BGainey%2C+Lindsey+O%3BXiao%2C+Jian%3BNanes%2C+Mark+S%3BHou%2C+Anji%3BYou%2C+Shaojin%3BChen%2C+Qiong&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2009-06-01&rft.volume=140&rft.issue=6&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=1943-4723&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Number of references - 1 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Metastases; Vascular endothelial growth factor; Focal adhesion kinase; Progesterone; Dephosphorylation; Src protein; Brain; Breast cancer; Gelatinase B; Cell migration; Signal transduction; Sex hormones DO - http://dx.doi.org/10.1155/2015/426429 ER - TY - JOUR T1 - Changes in Sexual Behavior of HIV-Infected Older Adults Enrolled in a Clinical Trial of Standalone Group Psychotherapies Targeting Depression AN - 1680149582; 201502996 AB - By 2015, one-half of all HIV-positive persons in the U.S. will be 50-plus years of age, and as many as 30 % of older adults living with HIV/AIDS continue to engage in unprotected sexual intercourse. Contemporary positive prevention models often include mental health treatment as a key component of HIV prevention interventions. This secondary data analysis characterized longitudinal patterns of sexual behavior in HIV-positive older adults enrolled in a randomized controlled trial of group mental health interventions and assessed the efficacy of psychosocial treatments that targeted depression to reduce sexual risk behavior. Participants were 295 HIV-positive adults >=50 years of age experiencing mild to severe depressive symptoms, randomized to one of three study conditions: a 12-session coping improvement group intervention, a 12-session interpersonal support group intervention, or individual therapy upon request. Approximately one-fifth of participants reported one or more occasions of unprotected anal or vaginal intercourse with HIV-negative sexual partners or persons of unknown HIV serostatus over the study period. Changes in sexual behavior did not vary by intervention condition, indicating that standalone treatments that target and reduce depression may be insufficient to reduce sexual risk behavior in depressed HIV-positive older adults. Adapted from the source document. JF - AIDS and Behavior AU - Lovejoy, Travis I AU - Heckman, Timothy G AU - Sikkema, Kathleen J AU - Hansen, Nathan B AU - Kochman, Arlene AD - Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA travis.lovejoy@va.gov Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 1 EP - 8 PB - Springer, Dordrecht, The Netherlands VL - 19 IS - 1 SN - 1090-7165, 1090-7165 KW - Risk KW - Sexual Behavior KW - Prevention KW - Depression (Psychology) KW - Acquired Immune Deficiency Syndrome KW - Elderly KW - Medical Research KW - Intervention KW - Sexual Intercourse KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680149582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Changes+in+Sexual+Behavior+of+HIV-Infected+Older+Adults+Enrolled+in+a+Clinical+Trial+of+Standalone+Group+Psychotherapies+Targeting+Depression&rft.au=Lovejoy%2C+Travis+I%3BHeckman%2C+Timothy+G%3BSikkema%2C+Kathleen+J%3BHansen%2C+Nathan+B%3BKochman%2C+Arlene&rft.aulast=Lovejoy&rft.aufirst=Travis&rft.date=2015-01-01&rft.volume=19&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-014-0746-7 LA - English DB - Social Services Abstracts N1 - Date revised - 2015-05-01 N1 - Number of references - 29 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Elderly; Intervention; Acquired Immune Deficiency Syndrome; Sexual Behavior; Depression (Psychology); Prevention; Medical Research; Risk; Sexual Intercourse DO - http://dx.doi.org/10.1007/s10461-014-0746-7 ER - TY - JOUR T1 - Active Injection Drug-Abuse Offsets Healthcare Engagement in HIV-Infected Patients AN - 1680149467; 201502992 AB - Active injection drug use (IDU) is a behavior with the potential to offset healthcare engagement for those with HIV. At the Washington DC Veterans Affairs Medical Center, we identified 316 patients with a history of addiction during an 11-year period while actively engaged in routine visits to our HIV-primary care clinic. Among all IDU, active-abuse was determined in 141/316 (45 %). There were 120 clinically relevant blood stream infection (BSI) episodes. HIV/HCV co-infection (95 %) and use of antiretroviral therapy (76 %) were common at the time of BSI. The majority of BSIs occurred among those with active-IDU (72/120, 60 %). Active-IDU behavior was associated with more thrombotic disease (12 vs. 2 %, P = 0.001) and more frequent hospitalization (1.1/year +/- 1.2 vs. 0.8/year +/- 1.1, P = 0.03). When compared to drug-users with no active injection practices or those with remote IDU, active-IDU was associated with an increase in all-cause mortality (43 vs. 27 %, P = 0.003) and a decrease in age-adjusted survival (HR 1.7, CI 1.16-2.51, P = 0.007). Addressing addiction has the potential to impact avoidable medical complications and contribute to the continued, overall health of patients linked to HIV-care. Adapted from the source document. JF - AIDS and Behavior AU - Liappis, Angelike P AU - Laake, Ann M AU - Delman, Mark AD - Medical Service, Section of Infectious Diseases, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC, 20422, USA angelike.liappis@va.gov Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 81 EP - 84 PB - Springer, Dordrecht, The Netherlands VL - 19 IS - 1 SN - 1090-7165, 1090-7165 KW - Veterans KW - Mortality Rates KW - Drug Injection KW - Acquired Immune Deficiency Syndrome KW - Clinics KW - Medicine KW - Patients KW - Addiction KW - Health Care Services KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680149467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Active+Injection+Drug-Abuse+Offsets+Healthcare+Engagement+in+HIV-Infected+Patients&rft.au=Liappis%2C+Angelike+P%3BLaake%2C+Ann+M%3BDelman%2C+Mark&rft.aulast=Liappis&rft.aufirst=Angelike&rft.date=2015-01-01&rft.volume=19&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-014-0757-4 LA - English DB - Social Services Abstracts N1 - Date revised - 2015-05-01 N1 - Number of references - 11 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Patients; Health Care Services; Addiction; Acquired Immune Deficiency Syndrome; Medicine; Clinics; Drug Injection; Mortality Rates; Veterans DO - http://dx.doi.org/10.1007/s10461-014-0757-4 ER - TY - JOUR T1 - Delivering Chaplaincy Services to Veterans at Increased Risk of Suicide AN - 1665159012 AB - The present study quantitatively examines the delivery of chaplaincy services to Veterans at increased risk of suicide as well as how chaplains collaborate with other healthcare providers. An on-line survey was distributed to the nationwide network of U.S. Department of Veterans Affairs chaplains, yielding a response rate of 11.91% ( N = 118). Most chaplains reported some form of training in suicide prevention, approximately half were involved in safety planning, and the majority reported not engaging in firearm safety counseling. Chaplaincy services were usually delivered through in-person, group, and phone consultations. Respondents were generally satisfied with their collaboration with other healthcare providers, most often collaborating with psychologists, social workers, and counselors. As a descriptive study, the findings serve to inform the delivery of chaplaincy services to at-risk Veterans. Recommendations include expanding service delivery options, developing competency in safety planning and counseling, as well as increasing institutional awareness of chaplaincy services. JF - Journal of Health Care Chaplaincy AU - Kopacz, Marek S AU - Pollitt, Michael J AD - U.S. Department of Veterans Affairs, VISN 2 Center of Excellence for Suicide Prevention, Canandaigua, New York, USA ; U.S. Department of Veterans Affairs, National Chaplain Center, Hampton, Virginia, USA ; U.S. Department of Veterans Affairs, VISN 2 Center of Excellence for Suicide Prevention, Canandaigua, New York, USA Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 1 EP - 13 CY - Philadelphia PB - Taylor & Francis Ltd. VL - 21 IS - 1 SN - 0885-4726 KW - Religions And Theology KW - At risk KW - Chaplains KW - Counselling KW - Counselling services KW - Health care KW - Internet KW - Preventive programmes KW - Psychologists KW - Response rate KW - Safety KW - Service delivery KW - Social workers KW - Suicide KW - Veterans KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665159012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+Chaplaincy&rft.atitle=Delivering+Chaplaincy+Services+to+Veterans+at+Increased+Risk+of+Suicide&rft.au=Kopacz%2C+Marek+S%3BPollitt%2C+Michael+J&rft.aulast=Kopacz&rft.aufirst=Marek&rft.date=2015-01-01&rft.volume=21&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+Chaplaincy&rft.issn=08854726&rft_id=info:doi/10.1080%2F08854726.2014.967525 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Department of Veterans Affairs N1 - Date revised - 2015-02-05 N1 - Last updated - 2016-05-12 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1080/08854726.2014.967525 ER - TY - JOUR T1 - Lowered Humidity Produces Human Epidermal Equivalents with Enhanced Barrier Properties AN - 1647009725; 21327046 AB - Multilayered human keratinocyte cultures increasingly are used to model human epidermis. Until now, studies utilizing human epidermal equivalents (HEEs) have been limited because previous preparations do not establish a normal epidermal permeability barrier. In this report, we show that reducing environmental humidity to 50% relative humidity yields HEEs that closely match human postnatal epidermis and have enhanced repair of the permeability barrier. These cultures display low transepidermal water loss and possess a calcium and pH gradient that resembles those seen in human epidermis. These cultures upregulate glucosylceramide synthase and make normal-appearing lipid lamellar bilayers. The epidermal permeability barrier of these cultures can be perturbed, using the identical tools previously described for human skin, and recover in the same time course seen during in vivo barrier recovery. These cultures will be useful for basic and applied studies on epidermal barrier function. JF - Tissue Engineering, Part C: Methods AU - Sun, Richard AU - Celli, Anna AU - Crumrine, Debra AU - Hupe, Melanie AU - Adame, Lillian C AU - Pennypacker, Sally D AU - Park, Kyungho AU - Uchida, Yoshikazu AU - Feingold, Kenneth R AU - Elias, Peter M AU - Ilic, Dusko AU - Mauro, Theodora M AD - Department of Dermatology, San Francisco Veterans Administration Medical Center, San Francisco, California. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 15 EP - 22 PB - Mary Ann Liebert, Inc., 140 Huguenot St 3rd Fl New Rochelle NY 10801 United States VL - 21 IS - 1 SN - 1937-3384, 1937-3384 KW - Biotechnology and Bioengineering Abstracts KW - Relative humidity KW - Skin KW - Calcium KW - Lipids KW - Humidity KW - Tissue engineering KW - Permeability KW - Epidermis KW - Water loss KW - Ceramide glucosyltransferase KW - Keratinocytes KW - pH effects KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647009725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+C%3A+Methods&rft.atitle=Lowered+Humidity+Produces+Human+Epidermal+Equivalents+with+Enhanced+Barrier+Properties&rft.au=Sun%2C+Richard%3BCelli%2C+Anna%3BCrumrine%2C+Debra%3BHupe%2C+Melanie%3BAdame%2C+Lillian+C%3BPennypacker%2C+Sally+D%3BPark%2C+Kyungho%3BUchida%2C+Yoshikazu%3BFeingold%2C+Kenneth+R%3BElias%2C+Peter+M%3BIlic%2C+Dusko%3BMauro%2C+Theodora+M&rft.aulast=Sun&rft.aufirst=Richard&rft.date=2015-01-01&rft.volume=21&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+C%3A+Methods&rft.issn=19373384&rft_id=info:doi/10.1089%2Ften.tec.2014.0065 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Number of references - 53 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Relative humidity; Epidermis; Permeability; Calcium; Skin; Lipids; Ceramide glucosyltransferase; Water loss; Humidity; Keratinocytes; Tissue engineering; pH effects DO - http://dx.doi.org/10.1089/ten.tec.2014.0065 ER - TY - JOUR T1 - Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. AN - 1640331453; 25283348 AB - Angiogenesis is regulated by hyperglycemic conditions, which can induce cellular stress responses, reactive oxygen species (ROS), and anti-oxidant defenses that modulate intracellular signaling to prevent oxidative damage. The RUNX2 DNA-binding transcription factor is activated by a glucose-mediated intracellular pathway, plays an important role in endothelial cell (EC) function and angiogenesis, and is a target of oxidative stress. RUNX2 DNA-binding and EC differentiation in response to glucose were conserved in ECs from different tissues and inhibited by hyperglycemia, which stimulated ROS production through the aldose reductase glucose-utilization pathway. Furthermore, the redox status of cysteine and methionine residues regulated RUNX2 DNA-binding and reversal of oxidative inhibition was consistent with an endogenous Methionine sulfoxide reductase-A (MsrA) activity. Low molecular weight MsrA substrates and sulfoxide scavengers were potent inhibitors of RUNX2 DNA binding in the absence of oxidative stress, but acted as antioxidants to increase DNA binding in the presence of oxidants. MsrA was associated with RUNX2:DNA complexes, as measured by a sensitive, quantitative DNA-binding ELISA. The related RUNX2 protein family member, RUNX1, which contains an identical DNA-binding domain, was a catalytic substrate of recombinant MsrA. These findings define novel redox pathways involving aldose reductase and MsrA that regulate RUNX2 transcription factor activity and biological function in ECs. Targeting of these pathways could result in more effective strategies to alleviate the vascular dysfunction associated with diabetes or cancer. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Microvascular research AU - Mochin, Maria T AU - Underwood, Karen F AU - Cooper, Brandon AU - McLenithan, John C AU - Pierce, Adam D AU - Nalvarte, Cesar AU - Arbiser, Jack AU - Karlsson, Anna I AU - Moise, Alexander R AU - Moskovitz, Jackob AU - Passaniti, Antonino AD - Department of Pathology, The University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Biochemistry & Molecular Biology, The University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Medicine, The University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene & Stewart Greenebaum Cancer Center, The University of Maryland School of Medicine, Baltimore, MD 21201, USA. ; Department of Dermatology, Emory University, Atlanta, GA, USA; Atlanta Veterans Administration Medical Center, Atlanta, GA, USA. ; Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045, USA. ; Department of Pathology, The University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Biochemistry & Molecular Biology, The University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Medicine, The University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene & Stewart Greenebaum Cancer Center, The University of Maryland School of Medicine, Baltimore, MD 21201, USA; The Veteran's Health Administration Research & Development Service, Baltimore, MD, USA. Electronic address: apass001@umaryland.edu. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 55 EP - 64 VL - 97 KW - Angiogenesis Inhibitors KW - 0 KW - Antioxidants KW - Core Binding Factor Alpha 1 Subunit KW - Core Binding Factor Alpha 2 Subunit KW - Oxidants KW - RUNX1 protein, human KW - RUNX2 protein, human KW - DNA KW - 9007-49-2 KW - Aldehyde Reductase KW - EC 1.1.1.21 KW - Methionine Sulfoxide Reductases KW - EC 1.8.4.- KW - methionine sulfoxide reductase KW - EC 1.8.4.11 KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Endothelial cell differentiation KW - Oxidative stress KW - Angiogenesis KW - Transcriptional factors KW - Antioxidant enzymes KW - Human Umbilical Vein Endothelial Cells -- metabolism KW - Oxidants -- pharmacology KW - Dose-Response Relationship, Drug KW - Humans KW - Methionine Sulfoxide Reductases -- metabolism KW - Aldehyde Reductase -- metabolism KW - Binding Sites KW - Phenotype KW - Oxidation-Reduction KW - Angiogenesis Inhibitors -- pharmacology KW - Antioxidants -- pharmacology KW - Cells, Cultured KW - Oxidative Stress KW - Core Binding Factor Alpha 2 Subunit -- metabolism KW - Substrate Specificity KW - Time Factors KW - Signal Transduction KW - Core Binding Factor Alpha 1 Subunit -- metabolism KW - Endothelial Cells -- drug effects KW - Hyperglycemia -- metabolism KW - Glucose -- metabolism KW - DNA -- metabolism KW - Neovascularization, Pathologic KW - Endothelial Cells -- pathology KW - Hyperglycemia -- pathology KW - Hyperglycemia -- physiopathology KW - Endothelial Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1640331453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microvascular+research&rft.atitle=Hyperglycemia+and+redox+status+regulate+RUNX2+DNA-binding+and+an+angiogenic+phenotype+in+endothelial+cells.&rft.au=Mochin%2C+Maria+T%3BUnderwood%2C+Karen+F%3BCooper%2C+Brandon%3BMcLenithan%2C+John+C%3BPierce%2C+Adam+D%3BNalvarte%2C+Cesar%3BArbiser%2C+Jack%3BKarlsson%2C+Anna+I%3BMoise%2C+Alexander+R%3BMoskovitz%2C+Jackob%3BPassaniti%2C+Antonino&rft.aulast=Mochin&rft.aufirst=Maria&rft.date=2015-01-01&rft.volume=97&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Microvascular+research&rft.issn=1095-9319&rft_id=info:doi/10.1016%2Fj.mvr.2014.09.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-25 N1 - Date created - 2014-12-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Adv Cardiol. 2008;45:1-16 [18230953] Dev Biol. 2008 Mar 15;315(2):459-73 [18262513] Trends Biochem Sci. 2010 Sep;35(9):505-13 [20430626] Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18628-33 [20937881] Endocrinology. 2008 Apr;149(4):1697-704 [18162513] Free Radic Biol Med. 2008 Jul 15;45(2):193-200 [18466776] Mol Cell Biol. 2008 Aug;28(16):5106-19 [18559422] Free Radic Biol Med. 2008 Sep 1;45(5):549-61 [18544350] Am J Physiol Cell Physiol. 2008 Oct;295(4):C849-68 [18684987] Biopolymers. 2009 Jan;91(1):78-84 [18781628] J Biol Chem. 2009 Feb 27;284(9):5986-93 [18990697] Arch Biochem Biophys. 2009 May 1;485(1):35-40 [19388147] J Biol Chem. 2009 Jul 3;284(27):17947-55 [19383984] J Mol Neurosci. 2009 Nov;39(3):323-32 [19653131] Neurosci Lett. 2010 Jan 1;468(1):38-41 [19854239] Sci Transl Med. 2010 Jan 20;2(15):15ps3 [20371469] Neuroscience. 2011 Mar 17;177:223-9 [21219974] Cell. 2011 Sep 16;146(6):873-87 [21925313] J Cell Biochem. 2012 Jan;113(1):282-92 [21913213] Sci Transl Med. 2011 Dec 21;3(114):114rv3 [22190240] J Biochem. 2012 Mar;151(3):255-61 [22287686] J Bone Miner Res. 2012 Apr;27(4):913-25 [22189971] J Vis Exp. 2013;(78). doi: 10.3791/50512 [24022461] Cell Metab. 2013 Oct 1;18(4):478-89 [24035587] Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20057-62 [24277839] Nat Rev Endocrinol. 2014 Sep;10(9):530-9 [25048037] Oncogene. 2000 Jan 6;19(1):106-14 [10644985] J Biol Chem. 2000 May 12;275(19):14167-72 [10799493] Nucleic Acids Res. 2001 Feb 15;29(4):E21 [11160941] Cell. 2001 Mar 9;104(5):755-67 [11257229] Cancer Res. 2001 Jul 1;61(13):4994-5001 [11431332] Mech Dev. 2001 Aug;106(1-2):97-106 [11472838] Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12920-5 [11606777] Nature. 2001 Dec 13;414(6865):813-20 [11742414] Biochem Biophys Res Commun. 2002 Jan 11;290(1):62-5 [11779133] Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):13969-71 [12391310] Endocrinology. 2003 Jan;144(1):346-52 [12488363] Toxicol Pathol. 2002 Nov-Dec;30(6):620-50 [12512863] Eur Respir J. 2003 Jan;21(1):177-86 [12570126] Int J Clin Oncol. 2003 Aug;8(4):200-6 [12955574] Antioxid Redox Signal. 2003 Oct;5(5):577-82 [14580313] Oncogene. 2004 Jun 10;23(27):4722-34 [15107836] J Bone Miner Res. 2004 Sep;19(9):1481-9 [15312248] J Biol Chem. 2004 Oct 8;279(41):42709-18 [15304489] J Nutr. 2004 Nov;134(11):3213S-3214S [15514312] J Natl Cancer Inst. 1994 Sep 7;86(17):1303-14 [7520508] J Bacteriol. 1995 Feb;177(3):502-7 [7836279] J Biol Chem. 1996 Jul 12;271(28):16870-6 [8663420] Biochem J. 1996 Sep 1;318 ( Pt 2):379-82 [8809022] Gene. 1997 Jan 31;185(1):111-7 [9034321] Cell. 1997 May 30;89(5):755-64 [9182763] Oncogene. 1998 Mar 5;16(9):1217-22 [9528864] Aging (Milano). 1998 Apr;10(2):149-51 [9666202] Free Radic Biol Med. 1998 Dec;25(9):1089-97 [9870563] Biochim Biophys Acta. 2005 Jan 17;1703(2):135-40 [15680221] Biochim Biophys Acta. 2005 Jan 17;1703(2):203-12 [15680228] Biochim Biophys Acta. 2005 Jan 17;1703(2):213-9 [15680229] Oncogene. 2005 Feb 24;24(9):1641-7 [15674341] J Bone Miner Res. 2005 Mar;20(3):428-37 [15746987] Nat Rev Cancer. 2005 May;5(5):376-87 [15864279] Endocr Rev. 2005 May;26(3):380-92 [15814847] J Biol Chem. 2006 Mar 17;281(11):7118-28 [16407259] Circulation. 2006 Apr 18;113(15):1888-904 [16618833] Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1549-61 [16987010] Bone. 2007 Jul;41(1):25-32 [17475575] BMC Cancer. 2007;7:172 [17784942] Curr Top Dev Biol. 2008;80:93-133 [17950373] Cancer Biol Ther. 2007 Jun;6(6):856-63 [17438369] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.mvr.2014.09.008 ER - TY - JOUR T1 - Shared genetic factors influence amygdala volumes and risk for alcoholism. AN - 1637552821; 25079289 AB - Alcohol abuse and dependence (alcohol use disorders, AUDs) are associated with brain shrinkage. Subcortical structures including the amygdala, hippocampus, ventral striatum, dorsal striatum, and thalamus subserve reward functioning and may be particularly vulnerable to alcohol-related damage. These structures may also show pre-existing deficits impacting the development and maintenance of AUD. It remains unclear whether there are common genetic features underlying both subcortical volumes and AUD. In this study, structural brain images were acquired from 872 Mexican-American individuals from extended pedigrees. Subcortical volumes were obtained using FreeSurfer, and quantitative genetic analyses were performed in SOLAR. We hypothesized the following: (1) reduced subcortical volumes in individuals with lifetime AUD relative to unrelated controls; (2) reduced subcortical volumes in individuals with current relative to past AUD; (3) in non-AUD individuals, reduced subcortical volumes in those with a family history of AUD compared to those without; and (4) evidence for common genetic underpinnings (pleiotropy) between AUD risk and subcortical volumes. Results showed that individuals with lifetime AUD showed larger ventricular and smaller amygdala volumes compared to non-AUD individuals. For the amygdala, there were no differences in volume between current vs past AUD, and non-AUD individuals with a family history of AUD demonstrated reductions compared to those with no such family history. Finally, amygdala volume was genetically correlated with the risk for AUD. Together, these results suggest that reduced amygdala volume reflects a pre-existing difference rather than alcohol-induced neurotoxic damage. Our genetic correlation analysis provides evidence for a common genetic factor underlying both reduced amygdala volumes and AUD risk. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Dager, Alecia D AU - McKay, D Reese AU - Kent, Jack W AU - Curran, Joanne E AU - Knowles, Emma AU - Sprooten, Emma AU - Göring, Harald H H AU - Dyer, Thomas D AU - Pearlson, Godfrey D AU - Olvera, Rene L AU - Fox, Peter T AU - Lovallo, William R AU - Duggirala, Ravi AU - Almasy, Laura AU - Blangero, John AU - Glahn, David C AD - 1] Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA [2] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. ; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. ; Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA. ; 1] Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, USA [2] South Texas Veterans Health System, San Antonio, TX, USA. ; Department of Psychiatry, Oklahoma University Heath Science Center and Veterans Administration Medical Center, Oklahoma City, OK, USA. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 412 EP - 420 VL - 40 IS - 2 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Young Adult KW - Humans KW - Aged KW - Organ Size KW - Risk KW - Mexican Americans -- genetics KW - Aged, 80 and over KW - Adult KW - Family KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Genetic Pleiotropy KW - Alcohol-Related Disorders -- genetics KW - Genetic Predisposition to Disease KW - Amygdala -- pathology KW - Alcohol-Related Disorders -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1637552821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Shared+genetic+factors+influence+amygdala+volumes+and+risk+for+alcoholism.&rft.au=Dager%2C+Alecia+D%3BMcKay%2C+D+Reese%3BKent%2C+Jack+W%3BCurran%2C+Joanne+E%3BKnowles%2C+Emma%3BSprooten%2C+Emma%3BG%C3%B6ring%2C+Harald+H+H%3BDyer%2C+Thomas+D%3BPearlson%2C+Godfrey+D%3BOlvera%2C+Rene+L%3BFox%2C+Peter+T%3BLovallo%2C+William+R%3BDuggirala%2C+Ravi%3BAlmasy%2C+Laura%3BBlangero%2C+John%3BGlahn%2C+David+C&rft.aulast=Dager&rft.aufirst=Alecia&rft.date=2015-01-01&rft.volume=40&rft.issue=2&rft.spage=412&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=1740-634X&rft_id=info:doi/10.1038%2Fnpp.2014.187 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-18 N1 - Date created - 2014-12-16 N1 - Date revised - 2017-01-24 N1 - SuppNotes - Cited By: Am J Med Genet B Neuropsychiatr Genet. 2011 Jul;156B(5):561-8 [21557468] Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15037-42 [21402948] Alcohol Clin Exp Res. 2011 Oct;35(10):1771-93 [21777260] Biol Psychiatry. 2012 Jan 1;71(1):6-14 [21982424] Twin Res Hum Genet. 2012 Jun;15(3):351-71 [22856370] Arch Gen Psychiatry. 2012 Aug;69(8):842-52 [22868938] Alcohol Clin Exp Res. 2013 Jan;37 Suppl 1:E161-71 [23078363] Alcohol Res Health. 2008;31(3):215-30 [20041042] Psychopharmacology (Berl). 2014 Apr;231(8):1731-42 [24553579] Biol Psychiatry. 2014 May 15;75(10):790-7 [24314346] Brain Imaging Behav. 2014 Jun;8(2):143-52 [24297733] Neuron. 2002 Jan 31;33(3):341-55 [11832223] Neurology. 2002 Mar 12;58(5):695-701 [11889230] Neuroimage. 2002 Oct;17(2):825-41 [12377157] Neuroimage. 2002 Oct;17(2):922-7 [12377166] J Stud Alcohol. 2003 Jan;64(1):98-104 [12608489] Arch Gen Psychiatry. 2003 Jul;60(7):727-35 [12860777] Arch Gen Psychiatry. 2003 Sep;60(9):878-88 [12963669] Cereb Cortex. 2004 Jul;14(7):721-30 [15054051] Psychiatr Dev. 1985 Spring;3(1):31-63 [3889898] Neuropsychopharmacology. 1991 May;4(3):175-86 [2064717] Brain Res. 1997 Jun 20;760(1-2):94-101 [9237523] Genet Epidemiol. 1997;14(6):953-8 [9433606] Am J Hum Genet. 1998 May;62(5):1198-211 [9545414] Adv Genet. 2001;42:151-81 [11037320] Biol Psychiatry. 2001 Jun 1;49(11):894-905 [11377407] Am J Psychiatry. 2001 Jul;158(7):1075-83 [11431229] Alcohol Clin Exp Res. 1998 Apr;22(2):534-8 [9581665] Neuroimage. 1999 Feb;9(2):195-207 [9931269] Ann N Y Acad Sci. 1999 Jun 29;877:445-60 [10415664] Nat Rev Genet. 2005 Jul;6(7):521-32 [15995696] Neuroimage. 2006 Aug 1;32(1):180-94 [16651008] Neuroimage. 2006 Sep;32(3):1465-71 [16872844] Hum Brain Mapp. 2006 Dec;27(12):957-62 [16628607] Neuroimage. 2007 Feb 1;34(3):879-87 [17127079] Addict Biol. 2007 Mar;12(1):122-32 [17407506] Biol Psychiatry. 2008 Aug 1;64(3):192-202 [18374900] Am J Psychiatry. 2008 Sep;165(9):1179-84 [18593776] Neuropsychol Rev. 2010 Mar;20(1):1-20 [19685291] Am J Drug Alcohol Abuse. 2010 May;36(3):161-7 [20465374] Neuroimage. 2010 Nov 15;53(3):1135-46 [20006715] Arch Gen Psychiatry. 1998 Oct;55(10):905-12 [9783561] J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57 [9881538] Neuroimage. 1999 Feb;9(2):179-94 [9931268] Alcohol Clin Exp Res. 2011 Jun;35(6):1187-200 [21410483] N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1038/npp.2014.187 ER - TY - JOUR T1 - Does universal active MRSA surveillance influence anti-MRSA antibiotic use? A retrospective analysis of the treatment of patients admitted with suspicion of infection at Veterans Affairs Medical Centers between 2005 and 2010 AN - 1701492861; PQ0001800725 AB - Objectives After the implementation of an active surveillance programme for MRSA in US Veterans Affairs (VA) Medical Centers, there was an increase in vancomycin use. We investigated whether positive MRSA admission surveillance tests were associated with MRSA-positive clinical admission cultures and whether the availability of surveillance tests influenced prescribers' ability to match initial anti-MRSA antibiotic use with anticipated MRSA results from clinical admission cultures. Methods Analyses were based on barcode medication administration data, microbiology data and laboratory data from 129 hospitals between January 2005 and September 2010. Hospitalized patient admissions were included if clinical cultures were obtained and antibiotics started within 2 days of admission. Mixed-effects logistic regression was used to examine associations between positive MRSA admission cultures and (i) admission MRSA surveillance test results and (ii) initial anti-MRSA therapy. Results Among 569815 included admissions, positive MRSA surveillance tests were strong predictors of MRSA-positive admission cultures (OR 8.5; 95% CI 8.2-8.8). The negative predictive value of MRSA surveillance tests was 97.6% (95% CI 97.5%-97.6%). The diagnostic OR between initial anti-MRSA antibiotics and MRSA-positive admission cultures was 3.2 (95% CI 3.1-3.4) for patients without surveillance tests and was not significantly different for admissions with surveillance tests. Conclusions The availability of nasal MRSA surveillance tests in VA hospitals did not seem to improve the ability of prescribers to predict the necessity of initial anti-MRSA treatment despite the high negative predictive value of MRSA surveillance tests. Prospective trials are needed to establish the safety and effectiveness of using MRSA surveillance tests to guide antibiotic therapy. JF - Journal of Antimicrobial Chemotherapy AU - Jones, Makoto AU - Huttner, Benedikt AU - Leecaster, Molly AU - Huttner, Angela AU - Damal, Kavitha AU - Tanner, Windy AU - Nielson, Christopher AU - Rubin, Michael A AU - Goetz, Matthew Bidwell AU - Madaras-Kelly, Karl AU - Samore, Matthew H AD - Corresponding author. VA Salt Lake City Health Care System, 500 Foothill Drive, Salt Lake City, UT 84148, USA. Tel: +1-801-582-1565, ext. 4474; Fax: +; , makoto.jones@va.gov Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 3401 EP - 3408 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 69 IS - 12 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - vancomycin KW - empirical treatment KW - definitive treatment KW - Data processing KW - Drug resistance KW - Vancomycin KW - Antibiotics KW - Infection KW - Clinical trials KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701492861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Does+universal+active+MRSA+surveillance+influence+anti-MRSA+antibiotic+use%3F+A+retrospective+analysis+of+the+treatment+of+patients+admitted+with+suspicion+of+infection+at+Veterans+Affairs+Medical+Centers+between+2005+and+2010&rft.au=Jones%2C+Makoto%3BHuttner%2C+Benedikt%3BLeecaster%2C+Molly%3BHuttner%2C+Angela%3BDamal%2C+Kavitha%3BTanner%2C+Windy%3BNielson%2C+Christopher%3BRubin%2C+Michael+A%3BGoetz%2C+Matthew+Bidwell%3BMadaras-Kelly%2C+Karl%3BSamore%2C+Matthew+H&rft.aulast=Jones&rft.aufirst=Makoto&rft.date=2014-12-01&rft.volume=69&rft.issue=12&rft.spage=3401&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdku299 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Data processing; Drug resistance; Vancomycin; Antibiotics; Infection; Clinical trials; Hospitals DO - http://dx.doi.org/10.1093/jac/dku299 ER - TY - JOUR T1 - Vancomycin Nephrotoxicity: A Review AN - 1691295208; PQ0001584889 AB - Vancomycin earned notoriety for its tendency to cause nephrotoxicity shortly after it was introduced into practice, though the impurities responsible for historically significant rates of nephrotoxicity are of minimal concern today. Increasing usage of vancomycin has provided evidence that the drug itself can be nephrotoxic, but the exact mechanism by which this occurs has not been determined. Various studies have identified risk factors associated with development of vancomycin-associated nephrotoxicity, including total daily dose > 4 grams, trough levels > 20 mg/L, therapy exceeding 6 days, concurrent use of other nephrotoxic agents, preexisting renal disease, obesity, hypotensive episodes, and increasing severity of illness. Preventative strategies beyond risk assessment and therapeutic drug monitoring have shown little promise. Most cases of nephrotoxicity are reversible with discontinuation of vancomycin, but permanent renal damage can occur. This article is intended to serve as a practical review of vancomycin-associated nephrotoxicity, including historical context, risk factors, and common methods to evaluate and define renal dysfunction. JF - Journal of Pharmacy Practice AU - Mergenhagen, Kari A AU - Borton, Angela R AD - Department of Pharmacy, Veterans Affairs Western New York Healthcare System, Buffalo, NY, USA, kari.mergenhagen@va.gov Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 545 EP - 553 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 27 IS - 6 SN - 0897-1900, 0897-1900 KW - Toxicology Abstracts; Risk Abstracts KW - vancomycin KW - nephrotoxicity KW - therapeutic drug monitoring KW - Risk assessment KW - Historical account KW - Obesity KW - Impurities KW - Kidney diseases KW - Drug screening KW - Renal KW - Renal function KW - Reviews KW - Risk factors KW - Vancomycin KW - Drugs KW - X 24310:Pharmaceuticals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691295208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmacy+Practice&rft.atitle=Vancomycin+Nephrotoxicity%3A+A+Review&rft.au=Mergenhagen%2C+Kari+A%3BBorton%2C+Angela+R&rft.aulast=Mergenhagen&rft.aufirst=Kari&rft.date=2014-12-01&rft.volume=27&rft.issue=6&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmacy+Practice&rft.issn=08971900&rft_id=info:doi/10.1177%2F0897190014546114 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Number of references - 39 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Risk assessment; Obesity; Renal function; Risk factors; Impurities; Kidney diseases; Vancomycin; Drug screening; Drugs; Renal; Historical account; Reviews DO - http://dx.doi.org/10.1177/0897190014546114 ER - TY - JOUR T1 - Post-traumatic growth among veterans in the USA: results from the National Health and Resilience in Veterans Study AN - 1665171705 AB - There is increasing recognition that, in addition to negative psychological consequences of trauma such as post-traumatic stress disorder (PTSD), some individuals may develop post-traumatic growth (PTG) following such experiences. To date, however, data regarding the prevalence, correlates and functional significance of PTG in population-based samples are lacking. Data were analysed from the National Health and Resilience in Veterans Study, a contemporary, nationally representative survey of 3157 US veterans. Veterans completed a survey containing measures of sociodemographic, military, health and psychosocial characteristics, and the Posttraumatic Growth Inventory-Short Form. We found that 50.1% of all veterans and 72.0% of veterans who screened positive for PTSD reported at least ‘moderate’ PTG in relation to their worst traumatic event. An inverted U-shaped relationship was found to best explain the relationship between PTSD symptoms and PTG. Among veterans with PTSD, those with PTSD reported better mental functioning and general health than those without PTG. Experiencing a life-threatening illness or injury and re-experiencing symptoms were most strongly associated with PTG. In multivariable analysis, greater social connectedness, intrinsic religiosity and purpose in life were independently associated with greater PTG. PTG is prevalent among US veterans, particularly among those who screen positive for PTSD. These results suggest that there may be a ‘positive legacy’ of trauma that has functional significance for veterans. They further suggest that interventions geared toward helping trauma-exposed US veterans process their re-experiencing symptoms, and to develop greater social connections, sense of purpose and intrinsic religiosity may help promote PTG in this population. JF - Psychological Medicine AU - Tsai, J AU - El-Gabalawy, R AU - Sledge, W H AU - Southwick, S M AU - Pietrzak, R H AD - United States Department of Veterans Affairs, New England Mental Illness Research, Education, and Clinical Center, West Haven, CT, USA, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA ; Department of Psychology, University of Manitoba, Winnipeg, Manitoba, Canada ; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA ; United States Department of Veterans Affairs, New England Mental Illness Research, Education, and Clinical Center, West Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 165 EP - 179 CY - Cambridge PB - Cambridge University Press VL - 45 IS - 1 SN - 0033-2917 KW - Psychology KW - Threatening KW - Traumatic life events KW - Traumatic stress KW - Veterans KW - Injuries KW - Interventions KW - Life threatening KW - Mental health KW - Personal growth KW - Posttraumatic stress disorder KW - Psychological trauma KW - Psychosocial factors KW - Purpose in life KW - Religiosity KW - Resilience KW - Sense of purpose KW - Sociodemographic aspects KW - Symptoms KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665171705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Post-traumatic+growth+among+veterans+in+the+USA%3A+results+from+the+National+Health+and+Resilience+in+Veterans+Study&rft.au=Tsai%2C+J%3BEl-Gabalawy%2C+R%3BSledge%2C+W+H%3BSouthwick%2C+S+M%3BPietrzak%2C+R+H&rft.aulast=Tsai&rft.aufirst=J&rft.date=2014-12-01&rft.volume=45&rft.issue=1&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291714001202 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-03-05 N1 - Last updated - 2016-08-16 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1017/S0033291714001202 ER - TY - JOUR T1 - Spouse health behavior outcomes from a randomized controlled trial of a spouse-assisted lifestyle change intervention to improve patient low-density lipoprotein cholesterol AN - 1665162030 AB - This study evaluated spouse health behavior outcomes from a randomized controlled trial of a spouse-assisted lifestyle intervention to reduce patient low-density lipoprotein cholesterol and improve patient health behaviors. Participants were 251 spouses of patients from the Durham Veterans Affairs Medical Center randomized to intervention or usual care. The intervention comprised 9 monthly telephone calls to patients and spouses. Outcomes were assessed at baseline, 6 and 11 months. At 11 months, there were no differences in spouse outcomes between intervention and usual care groups for moderate intensity physical activity (i.e., frequency, duration) or dietary intake (i.e., total calories, total fat, percentage of calories from total fat, saturated fat, percentage of calories from saturated fat, cholesterol, fiber). To improve spouse outcomes, couple interventions may need to include spouse behavior change goals and reciprocal support between patients and spouses and consider the need for improvement in spouse outcomes. JF - Journal of Behavioral Medicine AU - King, Heather A AU - Jeffreys, Amy S AU - McVay, Megan A AU - Coffman, Cynthia J AU - Voils, Corrine I AD - Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, HSR&D (152), 508 Fulton St., Durham, NC, 27705, USA heather.king2@va.gov heather.king2@va.gov; Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, HSR&D (152), 508 Fulton St., Durham, NC, 27705, USA, Department of Medicine, Duke University Medical Center, Durham, NC, USA ; Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, HSR&D (152), 508 Fulton St., Durham, NC, 27705, USA, Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA ; Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, HSR&D (152), 508 Fulton St., Durham, NC, 27705, USA Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1102 EP - 1107 CY - New York PB - Springer Science & Business Media VL - 37 IS - 6 SN - 0160-7715 KW - Psychology KW - Behavioural changes KW - Body fat KW - Cholesterol KW - Clinical outcomes KW - Density KW - Health behaviour KW - Health status KW - Interventions KW - Lifestyle KW - Physical activity KW - Spouses KW - Telephone calls KW - Veterans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665162030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Medicine&rft.atitle=Spouse+health+behavior+outcomes+from+a+randomized+controlled+trial+of+a+spouse-assisted+lifestyle+change+intervention+to+improve+patient+low-density+lipoprotein+cholesterol&rft.au=King%2C+Heather+A%3BJeffreys%2C+Amy+S%3BMcVay%2C+Megan+A%3BCoffman%2C+Cynthia+J%3BVoils%2C+Corrine+I&rft.aulast=King&rft.aufirst=Heather&rft.date=2014-12-01&rft.volume=37&rft.issue=6&rft.spage=1102&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Medicine&rft.issn=01607715&rft_id=info:doi/10.1007%2Fs10865-014-9559-4 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Veterans Affairs Medical Center-Boston MA N1 - Copyright - Copyright Springer Science & Business Media Dec 2014 N1 - Date revised - 2015-01-09 N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1007/s10865-014-9559-4 ER - TY - JOUR T1 - Outcomes of ceftriaxone use compared to standard of therapy in methicillin susceptible staphylococcal aureus (MSSA) bloodstream infections AN - 1639995259; 20983687 AB - Background Standard of care therapy (SOCT) for the treatment of methicillin susceptible staphylococcal aureus (MSSA) infections requires multiple daily infusions. Despite questionable efficacy due to high protein binding, ceftriaxone (CTX) is frequently used for treatment of MSSA at Hines VA Hospital. Objective The objective of this study was to determine clinical and microbiological outcomes in patients with MSSA bacteremia treated with CTX compared to SOCT. Setting This retrospective study was conducted at the Edward Hines, Jr. VA Hospital which is a comprehensive health care center serving the veteran population of the greater metropolitan Chicago and northwest Indiana regions and is institutionally affiliated with the Loyola University Medical Center. The Hines VA provides medical care to over 56,000 veterans and operates approximately 500 hospital beds, including acute care and nursing home beds. Method We conducted a retrospective cohort study of patients with MSSA bacteremia treated at Hines VA Hospital between January 2000 and September 2009. Patients who received either SOCT or CTX for >50 % of the treatment course and for the appropriate duration were included. Patients who were on multiple antibiotics concurrently or who received <14 days of therapy were excluded. Main outcome measure The primary outcome of this study is to compare clinical outcomes of patients with MSSA bacteremia who were treated with CTX compared to those who received standard of care agents. Results Ninety-three patients with MSSA bacteremia were included in the analysis. Fifty-one were treated with SOCT and 42 with CTX. There were no differences in microbiological cure between SOCT (94.1 %) and CTX (95.2 %) (p = 0.812). Clinical cure was similar between groups (74.5 % for SOCT, 83.3 % for CTX) (p = 0.303). CTX was used more often to treat Staphylococcus aureus bacteremia associated with osteomyelitis whereas endocarditis and central line associated infections were treated more frequently with SOCT (p = 0.01). More patients treated with CTX were managed in the ambulatory setting (64 vs. 24 %; p = <0.001). There was a trend toward a longer hospital stay with SOCT. Conclusion Clinical outcomes for MSSA bacteremia did not differ significantly between patients treated with CTX and SOCT. Findings suggest that CTX may be an alternative for outpatient management of MSSA bacteremia. JF - International Journal of Clinical Pharmacy AU - Patel, Ursula C AU - McKissic, Erin L AU - Kasper, Douglas AU - Lentino, Joseph R AU - Pachucki, Constance T AU - Lee, Todd AU - Lopansri, Bert K AD - Department of Pharmacy (119), Edward Hines, Jr. VA Hospital, 5000 S. Fifth Ave., Hines, IL, 60141, USA, ursula.patel@va.gov Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1282 EP - 1289 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 36 IS - 6 SN - 2210-7703, 2210-7703 KW - Microbiology Abstracts B: Bacteriology KW - Methicillin KW - Nursing KW - Bacteremia KW - Antibiotics KW - Ceftriaxone KW - Staphylococcus aureus KW - Infection KW - Hospitals KW - Endocarditis KW - Osteomyelitis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639995259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Clinical+Pharmacy&rft.atitle=Outcomes+of+ceftriaxone+use+compared+to+standard+of+therapy+in+methicillin+susceptible+staphylococcal+aureus+%28MSSA%29+bloodstream+infections&rft.au=Patel%2C+Ursula+C%3BMcKissic%2C+Erin+L%3BKasper%2C+Douglas%3BLentino%2C+Joseph+R%3BPachucki%2C+Constance+T%3BLee%2C+Todd%3BLopansri%2C+Bert+K&rft.aulast=Patel&rft.aufirst=Ursula&rft.date=2014-12-01&rft.volume=36&rft.issue=6&rft.spage=1282&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Clinical+Pharmacy&rft.issn=22107703&rft_id=info:doi/10.1007%2Fs11096-014-9999-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Number of references - 19 N1 - Last updated - 2015-03-04 N1 - SubjectsTermNotLitGenreText - Methicillin; Nursing; Bacteremia; Antibiotics; Ceftriaxone; Infection; Osteomyelitis; Endocarditis; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1007/s11096-014-9999-5 ER - TY - JOUR T1 - Asbestos-induced disruption of calcium homeostasis induces endoplasmic reticulum stress in macrophages. AN - 1629334896; 25324550 AB - Although the mechanisms for fibrosis development remain largely unknown, recent evidence indicates that endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) may act as an important fibrotic stimulus in diseased lungs. ER stress is observed in lungs of patients with idiopathic pulmonary fibrosis. In this study we evaluated if ER stress and the UPR was present in macrophages exposed to chrysotile asbestos and if ER stress in macrophages was associated with asbestos-induced pulmonary fibrosis. Macrophages exposed to chrysotile had elevated transcript levels of several ER stress genes. Macrophages loaded with the Ca(2+)-sensitive dye Fura2-AM showed that cytosolic Ca(2+) increased significantly within minutes after chrysotile exposure and remained elevated for a prolonged time. Chrysotile-induced increases in cytosolic Ca(2+) were partially inhibited by either anisomycin, an inhibitor of passive Ca(2+) leak from the ER, or 1,2-bis(2-aminophenoxyl)ethane-N,N,N',N'-tetraacetic acid (BAPTA-AM), an intracellular Ca(2+) chelator known to deplete ER Ca(2+) stores. Anisomycin inhibited X-box-binding protein 1 (XBP1) mRNA splicing and reduced immunoglobulin-binding protein (BiP) levels, whereas BAPTA-AM increased XBP1 splicing and BiP expression, suggesting that ER calcium depletion may be one factor contributing to ER stress in cells exposed to chrysotile. To evaluate ER stress in vivo, asbestos-exposed mice showed fibrosis development, and alveolar macrophages from fibrotic mice showed increased expression of BiP. Bronchoalveolar macrophages from asbestosis patients showed increased expression of several ER stress genes compared with normal subjects. These findings suggest that alveolar macrophages undergo ER stress, which is associated with fibrosis development. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. JF - The Journal of biological chemistry AU - Ryan, Alan J AU - Larson-Casey, Jennifer L AU - He, Chao AU - Murthy, Shuhba AU - Carter, A Brent AD - From the Departments of Internal Medicine. ; Radiation Oncology and Program in Free Radical and Radiation Biology, Carver College of Medicine. ; From the Departments of Internal Medicine, Radiation Oncology and Program in Free Radical and Radiation Biology, Carver College of Medicine, Human Toxicology, College of Public Health, University of Iowa, and Iowa City Veterans Administration Center, Iowa City, Iowa 52242 brent-carter@uiowa.edu. Y1 - 2014/11/28/ PY - 2014 DA - 2014 Nov 28 SP - 33391 EP - 33403 VL - 289 IS - 48 KW - Asbestos, Serpentine KW - 0 KW - DNA-Binding Proteins KW - Regulatory Factor X Transcription Factors KW - Transcription Factors KW - X-Box Binding Protein 1 KW - XBP1 protein, human KW - Xbp1 protein, mouse KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Asbestos KW - Fibrosis KW - Lung Injury KW - Macrophage KW - Endoplasmic Reticulum Stress (ER Stress) KW - Pulmonary Fibrosis KW - Animals KW - RNA Splicing -- drug effects KW - Transcription Factors -- metabolism KW - Humans KW - Adult KW - Mice KW - Adolescent KW - Male KW - Female KW - DNA-Binding Proteins -- metabolism KW - Macrophages, Alveolar -- metabolism KW - Calcium -- metabolism KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- chemically induced KW - Asbestosis -- pathology KW - Asbestos, Serpentine -- toxicity KW - Asbestosis -- metabolism KW - Macrophages, Alveolar -- pathology KW - Pulmonary Fibrosis -- metabolism KW - Endoplasmic Reticulum Stress -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629334896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Asbestos-induced+disruption+of+calcium+homeostasis+induces+endoplasmic+reticulum+stress+in+macrophages.&rft.au=Ryan%2C+Alan+J%3BLarson-Casey%2C+Jennifer+L%3BHe%2C+Chao%3BMurthy%2C+Shuhba%3BCarter%2C+A+Brent&rft.aulast=Ryan&rft.aufirst=Alan&rft.date=2014-11-28&rft.volume=289&rft.issue=48&rft.spage=33391&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M114.579870 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-10 N1 - Date created - 2014-11-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Immunity. 2013 Mar 21;38(3):555-69 [23477737] Curr Opin Rheumatol. 2012 Nov;24(6):663-8 [22918530] Biochim Biophys Acta. 2013 Jul;1833(7):1612-24 [23380704] J Biol Chem. 2013 Jul 12;288(28):20745-57 [23720777] Am J Respir Cell Mol Biol. 2013 Dec;49(6):892-901 [23885834] Science. 2000 Mar 3;287(5458):1647-51 [10698739] Mol Cell Biochem. 2003 Jun;248(1-2):41-7 [12870653] J Biol Chem. 2004 May 7;279(19):20108-17 [14978030] J Cell Sci. 2004 Aug 15;117(Pt 18):4135-42 [15280427] Proc Natl Acad Sci U S A. 1990 Apr;87(7):2466-70 [2138778] Cell. 1998 Mar 20;92(6):747-58 [9529251] J Biol Chem. 1999 Oct 22;274(43):30858-63 [10521478] J Clin Invest. 2005 Jan;115(1):56-65 [15630444] J Biol Chem. 2005 Jun 10;280(23):21763-72 [15826936] J Clin Invest. 2005 Oct;115(10):2656-64 [16200199] Cardiovasc Res. 2006 Mar 1;69(4):908-15 [16376871] Neurochem Int. 2006 Jun;48(8):696-702 [16481070] FASEB J. 2006 Jun;20(8):1215-7 [16611832] Blood. 2006 Sep 1;108(5):1635-42 [16690965] Mol Cell Biol. 2006 Dec;26(24):9220-31 [17030611] Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29 [17565364] Cell Metab. 2007 Aug;6(2):137-43 [17681149] Dev Cell. 2007 Sep;13(3):351-64 [17765679] Cell. 2007 Nov 2;131(3):596-610 [17981125] Cell Struct Funct. 2008;33(1):75-89 [18360008] Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1119-26 [18390830] Am J Respir Crit Care Med. 2008 Oct 15;178(8):838-46 [18635891] Nat Rev Drug Discov. 2008 Dec;7(12):1013-30 [19043451] J Cell Biol. 2009 Sep 21;186(6):783-92 [19752026] Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L846-55 [19684199] Biochem Pharmacol. 2010 May 1;79(9):1221-30 [20006589] J Biol Chem. 2010 Jul 16;285(29):22103-13 [20466729] Semin Liver Dis. 2010 Aug;30(3):245-57 [20665377] Clin Immunol. 2010 Oct;137(1):89-101 [20674506] Chem Biol Interact. 2010 Nov 5;188(2):309-18 [20380827] Methods Enzymol. 2011;490:31-51 [21266242] Am J Respir Cell Mol Biol. 2011 Mar;44(3):404-14 [20463293] Cold Spring Harb Perspect Biol. 2011 Jun;3(6). pii: a004317. doi: 10.1101/cshperspect.a004317 [21441595] Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10562-7 [21670280] J Exp Med. 2011 Jul 4;208(7):1339-50 [21727191] Nat Rev Mol Cell Biol. 2012 Feb;13(2):89-102 [22251901] J Biol Chem. 2012 Jan 27;287(5):3301-12 [22157762] J Biol Chem. 2012 Apr 6;287(15):11629-41 [22356914] Am J Physiol Lung Cell Mol Physiol. 2012 Apr 15;302(8):L721-9 [22287606] Am J Respir Cell Mol Biol. 2012 Jun;46(6):731-9 [21852685] Am J Respir Cell Mol Biol. 2012 Jun;46(6):748-56 [22227563] FASEB J. 2013 Apr;27(4):1600-9 [23322163] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1074/jbc.M114.579870 ER - TY - JOUR T1 - High serum iron is associated with increased cancer risk. AN - 1625344167; 25228650 AB - Epidemiologic studies linking high serum iron with cancer risks are limited and inconclusive, despite evidence implicating body iron in human carcinogenesis. A cohort of 309,443 adults in Taiwan who had no history of cancer had serum iron levels tested at the time of recruitment (1997-2008). Initially measured iron levels were associated with subsequent cancer risk by linking individuals with the National Cancer Registry and National Death File. HRs were calculated by the Cox model. One third of males (35%) and one fifth of females (18%) had high serum iron (≥120 μg/dL), which was associated with a 25% increase in risk for incidence of all cancers [HR, 1.25; 95% confidence interval (CI), 1.16-1.35] and with a 39% increase in risk for mortality from all cancers (HR, 1.39; 95% CI, 1.23-1.57). The relationship between serum iron and cancer risk was a J-shaped one, with higher cancer risk at both ends, either at lower than 60 μg/dL or higher than 120 μg/dL. At the higher end, cancer risk increased by 4% for every 10 μg/dL increment above 80 μg/dL, showing a dose-response relationship, with 60 to 79 μg/dL as a reference level. In a sensitivity analysis, the increases in risk were still observed after the first 5 years of cancer cases were excluded. Liver cancer risk was increased in HBV (-) non-hepatitis B carrier (3-fold) and HBV (+) hepatitis B carrier (24-fold). Lifestyle risks such as smoking, drinking, or inactivity interacted synergistically with high serum iron and significantly increased the cancer risks. The liver (HR, 2.49; 95% CI, 1.97-3.16) and the breast (HR, 1.31; 95% CI, 1.01-1.70) were the two major cancer sites where significant cancer risks were observed for serum iron either ≥120 μg/dL or ≥140 μg/dL, respectively. This study reveals that high serum iron is both a common disorder and a marker of increased risk for several cancers. ©2014 American Association for Cancer Research. JF - Cancer research AU - Wen, Chi Pang AU - Lee, June Han AU - Tai, Ya-Ping AU - Wen, Christopher AU - Wu, Shiuan Be AU - Tsai, Min Kuang AU - Hsieh, Dennis P H AU - Chiang, Hung-Che AU - Hsiung, Chao Agnes AU - Hsu, Chung Y AU - Wu, Xifeng AD - Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. China Medical University Hospital, Taichung, Taiwan. cwengood@nhri.org.tw. ; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. ; Long Beach Veterans Administration Hospital, University of Irvine, California. ; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Department of Environmental Toxicology, University of California, Davis. ; National Environmental Health Center, National Health Research Institutes, Zhunan, Taiwan. ; Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan. ; Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas. Y1 - 2014/11/15/ PY - 2014 DA - 2014 Nov 15 SP - 6589 EP - 6597 VL - 74 IS - 22 KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Life Style KW - Risk KW - Humans KW - Adult KW - Male KW - Female KW - Proportional Hazards Models KW - Neoplasms -- blood KW - Iron -- blood KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1625344167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=High+serum+iron+is+associated+with+increased+cancer+risk.&rft.au=Wen%2C+Chi+Pang%3BLee%2C+June+Han%3BTai%2C+Ya-Ping%3BWen%2C+Christopher%3BWu%2C+Shiuan+Be%3BTsai%2C+Min+Kuang%3BHsieh%2C+Dennis+P+H%3BChiang%2C+Hung-Che%3BHsiung%2C+Chao+Agnes%3BHsu%2C+Chung+Y%3BWu%2C+Xifeng&rft.aulast=Wen&rft.aufirst=Chi&rft.date=2014-11-15&rft.volume=74&rft.issue=22&rft.spage=6589&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-14-0360 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-08 N1 - Date created - 2014-11-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/0008-5472.CAN-14-0360 ER - TY - JOUR T1 - Transformer 2β homolog (Drosophila) (TRA2B) regulates protein kinase C δI (PKCδI) splice variant expression during 3T3L1 preadipocyte cell cycle. AN - 1625340816; 25261467 AB - Obesity is characterized by adipocyte hyperplasia and hypertrophy. We previously showed that PKCδ expression is dysregulated in obesity (Carter, G., Apostolatos, A., Patel, R., Mathur, A., Cooper, D., Murr, M., and Patel, N. A. (2013) ISRN Obes. 2013, 161345). Using 3T3L1 preadipocytes, we studied adipogenesis in vitro and showed that expression of PKCδ splice variants, PKCδI and PKCδII, have different expression patterns during adipogenesis (Patel, R., Apostolatos, A., Carter, G., Ajmo, J., Gali, M., Cooper, D. R., You, M., Bisht, K. S., and Patel, N. A. (2013) J. Biol. Chem. 288, 26834-26846). Here, we evaluated the role of PKCδI splice variant during adipogenesis. Our results indicate that PKCδI expression level is high in preadipocytes and decreasing PKCδI accelerated terminal differentiation. Our results indicate that PKCδI is required for mitotic clonal expansion of preadipocytes. We next evaluated the splice factor regulating the expression of PKCδI during 3T3L1 adipogenesis. Our results show TRA2B increased PKCδI expression. To investigate the molecular mechanism, we cloned a heterologous splicing PKCδ minigene and showed that inclusion of PKCδ exon 9 is increased by TRA2B. Using mutagenesis and a RNA-immunoprecipitation assay, we evaluated the binding of Tra2β on PKCδI exon 9 and show that its association is required for PKCδI splicing. These results provide a better understanding of the role of PKCδI in adipogenesis. Determination of this molecular mechanism of alternative splicing presents a novel therapeutic target in the management of obesity and its co-morbidities. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. JF - The Journal of biological chemistry AU - Patel, Rekha S AU - Carter, Gay AU - Cooper, Denise R AU - Apostolatos, Hercules AU - Patel, Niketa A AD - Department of Molecular Medicine, University of South Florida, Tampa, Florida 33612. ; From the James A. Haley Veterans Hospital and. ; Department of Molecular Medicine, University of South Florida, Tampa, Florida 33612 From the James A. Haley Veterans Hospital and. ; Department of Molecular Medicine, University of South Florida, Tampa, Florida 33612 From the James A. Haley Veterans Hospital and Niketa.Patel@va.gov npatel@health.usf.edu. Y1 - 2014/11/14/ PY - 2014 DA - 2014 Nov 14 SP - 31662 EP - 31672 VL - 289 IS - 46 KW - Nuclear Proteins KW - 0 KW - RNA-Binding Proteins KW - Tra2b protein, mouse KW - Serine-Arginine Splicing Factors KW - 170974-22-8 KW - Protein Kinase C-delta KW - EC 2.7.11.13 KW - Index Medicus KW - Obesity KW - Adipogenesis KW - Alternative Splicing KW - TRA2B KW - Protein Kinase C (PKC) KW - PRKCD KW - Cell Cycle KW - Animals KW - Apoptosis KW - Cell Differentiation KW - Mice KW - 3T3-L1 Cells KW - Cell Proliferation KW - Mutation KW - Adipocytes -- cytology KW - RNA-Binding Proteins -- metabolism KW - Protein Kinase C-delta -- metabolism KW - Gene Expression Regulation KW - Nuclear Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1625340816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Transformer+2%CE%B2+homolog+%28Drosophila%29+%28TRA2B%29+regulates+protein+kinase+C+%CE%B4I+%28PKC%CE%B4I%29+splice+variant+expression+during+3T3L1+preadipocyte+cell+cycle.&rft.au=Patel%2C+Rekha+S%3BCarter%2C+Gay%3BCooper%2C+Denise+R%3BApostolatos%2C+Hercules%3BPatel%2C+Niketa+A&rft.aulast=Patel&rft.aufirst=Rekha&rft.date=2014-11-14&rft.volume=289&rft.issue=46&rft.spage=31662&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M114.592337 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-20 N1 - Date created - 2014-11-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nat Rev Mol Cell Biol. 2006 Dec;7(12):885-96 [17139329] Gene Expr. 2006;13(2):73-84 [17017122] Am J Physiol Cell Physiol. 2007 Aug;293(2):C805-13 [17507429] Ann N Y Acad Sci. 2008 Oct;1139:197-205 [18991865] Mol Brain. 2008;1:12 [18945348] J Biol Chem. 2010 Jan 15;285(3):1879-87 [19917613] Genes Dev. 2010 Jun 1;24(11):1073-4 [20516191] J Biol Chem. 2010 Aug 20;285(34):25987-95 [20547768] Cell Metab. 2011 Aug 3;14(2):208-18 [21803291] PLoS Genet. 2011 Dec;7(12):e1002390 [22194695] J Biol Chem. 2012 Mar 16;287(12):9299-310 [22275369] J Biol Chem. 2012 May 11;287(20):16575-85 [22437831] J Endocrinol. 1997 Nov;155(2):217-8 [9415052] Biochem Soc Trans. 2012 Aug;40(4):784-8 [22817734] J Biol Chem. 2013 Sep 13;288(37):26834-46 [23902767] RNA Biol. 2014;11(4):351-9 [24658338] Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9618-23 [10931943] Biochem J. 2002 Nov 15;368(Pt 1):349-55 [12207561] Hum Mol Genet. 2004 Mar 1;13(5):509-24 [14709600] Prog Nucleic Acid Res Mol Biol. 2004;78:37-88 [15210328] Cell. 1975 May;5(1):19-27 [165899] J Cell Physiol. 1979 Oct;101(1):169-71 [541350] Science. 1986 Jul 18;233(4761):305-12 [3014651] Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9004-9 [8799144] J Biol Chem. 1997 May 23;272(21):13816-22 [9153238] DNA Cell Biol. 1997 Jun;16(6):679-90 [9212162] Int J Obes (Lond). 2005 Mar;29 Suppl 1:S13-6 [15711576] J Biol Chem. 2005 Sep 16;280(37):32107-14 [16051606] J Neurochem. 2006 Feb;96(3):635-44 [16371011] Int J Biochem Cell Biol. 2006;38(12):2151-63 [16950644] Mol Carcinog. 2007 May;46(5):381-90 [17219421] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1074/jbc.M114.592337 ER - TY - JOUR T1 - The effects of homelessness on Veterans' health care service use: an evaluation of independence from comorbidities AN - 1718059494; 2011-807975 AB - Objectives: This study evaluates the prevalence of Multiple Comorbid Chronic Disease (MCCD) within homeless and non-homeless Veterans and the association between MCCD and inpatient medical care. Methods: All individuals seen in the VA North Texas Health Care System between October 1, 2009 and September 30, 2010 (n = 102,034) were evaluated. Homelessness during the year and the number of common chronic diseases were evaluated for an association with likelihood of medical and psychiatric hospitalizations, bed days of care, inpatient substance treatment, rehabilitation admissions, and emergency department visits. Results: Homeless Veterans had higher all-cause mortality rates and rates of use of almost all resources after controlling for chronic disease burden using the Charlson Comorbidity Index, psychiatric illnesses, substance use disorders, and demographic variables. Conclusions: Homelessness Veterans are vulnerable to a high use of resources and mortality, independent of medical and psychiatric conditions. This finding should focus additional attention on reducing homelessness. [Copyright Elsevier B.V.] JF - Public Health AU - LePage, J P AU - Bradshaw, L D AU - Cipher, D J AU - Crawford, A M AU - Hoosyhar, D AD - VA North Texas Health Care System, USA James.lepage@va.gov Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 985 EP - 992 PB - Elsevier Ltd, The Netherlands VL - 128 IS - 11 SN - 0033-3506, 0033-3506 KW - Social conditions and policy - Social conditions and problems KW - Military and defense policy - Military personnel and veterans KW - Health conditions and policy - Medicine and health care KW - Health conditions and policy - Diseases and disorders KW - Population groups, population policy, and demographics - Demography and census KW - Social conditions and policy - Associations and meetings KW - Education and education policy - Information services and sources KW - Homelessness Chronic medical diseases Veterans Hospitalization Emergency department treatment Bed days of care KW - Veterans KW - Indexes KW - Mortality KW - Rehabilitation KW - Associations KW - Admission KW - Texas KW - Diseases KW - Medical service KW - Demographics KW - Homelessness KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718059494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health&rft.atitle=The+effects+of+homelessness+on+Veterans%27+health+care+service+use%3A+an+evaluation+of+independence+from+comorbidities&rft.au=LePage%2C+J+P%3BBradshaw%2C+L+D%3BCipher%2C+D+J%3BCrawford%2C+A+M%3BHoosyhar%2C+D&rft.aulast=LePage&rft.aufirst=J&rft.date=2014-11-01&rft.volume=128&rft.issue=11&rft.spage=985&rft.isbn=&rft.btitle=&rft.title=Public+Health&rft.issn=00333506&rft_id=info:doi/10.1016%2Fj.puhe.2014.07.004 LA - English DB - PAIS Index N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Homelessness; Veterans; Medical service; Diseases; Mortality; Associations; Rehabilitation; Indexes; Demographics; Texas; Admission DO - http://dx.doi.org/10.1016/j.puhe.2014.07.004 ER - TY - JOUR T1 - Clinician Perceptions of Using a Smartphone App with Prolonged Exposure Therapy AN - 1680150377; 201502747 AB - Clinician perceptions of clinical innovations affect their adoption and spread. This study investigated mental health clinicians' (n = 163) perceptions of a patient-facing smartphone application (app) for prolonged exposure (PE) therapy for posttraumatic stress disorder, before its public release. After reading a description of the app, participants rated perceptions of it based on diffusion of innovations theory constructs. Perceptions were generally favorable regarding the app's relative advantage over existing PE practices, compatibility with their values and needs, and complexity. Age (<40 years), smartphone ownership, and having used apps in care related to more favorable perceptions. Smartphone ownership, relative advantage, and complexity significantly predicted intention to use the app if it were available. These findings suggest that clinicians are receptive to using a PE app and that dissemination efforts should target sub-groups of PE clinicians to maximize adoption. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - Kuhn, Eric AU - Eftekhari, Afsoon AU - Hoffman, Julia E AU - Crowley, Jill J AU - Ramsey, Kelly M AU - Reger, Greg M AU - Ruzek, Josef I AD - Dissemination and Training Division, National Center for PTSD, VA Palo Alto Health Care System, 795 Willow Rd, Menlo Park, Palo Alto, CA, 94025, USA eric.kuhn@va.gov Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 800 EP - 807 PB - Springer, Dordrecht The Netherlands VL - 41 IS - 6 SN - 0894-587X, 0894-587X KW - Values KW - Mental Health KW - Diffusion KW - Ownership KW - Posttraumatic Stress Disorder KW - Adoption of Innovations KW - Innovations KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680150377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Clinician+Perceptions+of+Using+a+Smartphone+App+with+Prolonged+Exposure+Therapy&rft.au=Kuhn%2C+Eric%3BEftekhari%2C+Afsoon%3BHoffman%2C+Julia+E%3BCrowley%2C+Jill+J%3BRamsey%2C+Kelly+M%3BReger%2C+Greg+M%3BRuzek%2C+Josef+I&rft.aulast=Kuhn&rft.aufirst=Eric&rft.date=2014-11-01&rft.volume=41&rft.issue=6&rft.spage=800&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-013-0532-2 LA - English DB - Social Services Abstracts N1 - Date revised - 2015-05-01 N1 - Number of references - 24 N1 - Last updated - 2016-09-28 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Ownership; Innovations; Values; Posttraumatic Stress Disorder; Diffusion; Adoption of Innovations; Mental Health DO - http://dx.doi.org/10.1007/s10488-013-0532-2 ER - TY - JOUR T1 - Clinician Perceptions of Using a Smartphone App with Prolonged Exposure Therapy AN - 1665156044 AB - Clinician perceptions of clinical innovations affect their adoption and spread. This study investigated mental health clinicians’ ( n = 163) perceptions of a patient-facing smartphone application (app) for prolonged exposure (PE) therapy for posttraumatic stress disorder, before its public release. After reading a description of the app, participants rated perceptions of it based on diffusion of innovations theory constructs. Perceptions were generally favorable regarding the app’s relative advantage over existing PE practices, compatibility with their values and needs, and complexity. Age (<40 years), smartphone ownership, and having used apps in care related to more favorable perceptions. Smartphone ownership, relative advantage, and complexity significantly predicted intention to use the app if it were available. These findings suggest that clinicians are receptive to using a PE app and that dissemination efforts should target sub-groups of PE clinicians to maximize adoption. JF - Administration and Policy in Mental Health and Mental Health Services Research AU - Kuhn, Eric AU - Eftekhari, Afsoon AU - Hoffman, Julia E AU - Crowley, Jill J AU - Ramsey, Kelly M AU - Reger, Greg M AU - Ruzek, Josef I AD - Dissemination and Training Division, National Center for PTSD, VA Palo Alto Health Care System, 795 Willow Rd, Menlo Park, Palo Alto, CA, 94025, USA eric.kuhn@va.gov eric.kuhn@va.gov eric.kuhn@va.gov eric.kuhn@va.gov eric.kuhn@va.gov eric.kuhn@va.gov; National Center for Telehealth and Technology, Joint Base Lewis-McChord, Tacoma, WA, USA ; Dissemination and Training Division, National Center for PTSD, VA Palo Alto Health Care System, 795 Willow Rd, Menlo Park, Palo Alto, CA, 94025, USA Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 800 EP - 807 CY - New York PB - Springer Science & Business Media VL - 41 IS - 6 SN - 0894-587X KW - Public Health And Safety KW - Compatibility KW - Mental health professionals KW - Dissemination KW - Exposure therapy KW - In care KW - Innovations KW - Mental health KW - Ownership KW - Perceptions KW - Posttraumatic stress disorder KW - Release UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665156044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+and+Mental+Health+Services+Research&rft.atitle=Clinician+Perceptions+of+Using+a+Smartphone+App+with+Prolonged+Exposure+Therapy&rft.au=Kuhn%2C+Eric%3BEftekhari%2C+Afsoon%3BHoffman%2C+Julia+E%3BCrowley%2C+Jill+J%3BRamsey%2C+Kelly+M%3BReger%2C+Greg+M%3BRuzek%2C+Josef+I&rft.aulast=Kuhn&rft.aufirst=Eric&rft.date=2014-11-01&rft.volume=41&rft.issue=6&rft.spage=800&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+and+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-013-0532-2 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright Springer Science & Business Media Nov 2014 N1 - Date revised - 2015-01-09 N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1007/s10488-013-0532-2 ER - TY - JOUR T1 - Managing Uncertainty in Complex Interventional Fluoroscopic Procedures AN - 1642618364; 21055615 AB - There was a concern for potential patient skin bums indicated by air kerma as recorded by fluoroscopy equipment during two interventional fluoroscopic procedures. Two sentinel events as defined by The Joint Commission were indicated. Dose reconstruction based on measurements of machine output showed the air kerma readings were high by approximately a factor of four and no patient injury or sentinel event occurred. The radiation safety program in effect at the time of the incidents allowed discovery of equipment problems before a serious patient injury occurred, but additional controls have been implemented as a result, including quality control checks performed by cardiology, additional training, a database for tracking equipment maintenance, and mandatory entry of patient dose into electronic health records with follow-up orders automatically generated by the electronic health records. Most unexpected injuries are a result of multiple failures, but there are also multiple opportunities to prevent the injury. This paper provides a comprehensive look at patient safety concerns during two interventional cardiology fluoroscopic procedures and offers ways to flirther reduce risks to patients. It focuses on lessons learned and a systems-based approach to improving and promoting radiation safety during complex interventional fluoroscopic procedures. JF - Health Physics AU - Leuenberger, Ronald AU - Meade, Jason A AD - Louis Stokes Cleveland VA Medical Center, 10701 East Blvd USA (W), Cleveland, OH 44106., ronald.leuenberxer@va.gov Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - S181 EP - S187 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 107 IS - 3 SN - 0017-9078, 0017-9078 KW - Risk Abstracts KW - operational topics KW - exposure KW - radiation KW - medical radiation KW - safety standards KW - Skin KW - Injuries KW - Training KW - Quality control KW - Commissions KW - Safety KW - Tracking equipment KW - Risk reduction KW - Maintenance KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642618364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Managing+Uncertainty+in+Complex+Interventional+Fluoroscopic+Procedures&rft.au=Leuenberger%2C+Ronald%3BMeade%2C+Jason+A&rft.aulast=Leuenberger&rft.aufirst=Ronald&rft.date=2014-11-01&rft.volume=107&rft.issue=3&rft.spage=S181&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Skin; Injuries; Training; Quality control; Safety; Commissions; Risk reduction; Tracking equipment; Maintenance ER - TY - JOUR T1 - Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. AN - 1559008780; 25050737 AB - The purpose of the study was to examine the molecular mechanisms by which rottlerin inhibited growth of human pancreatic tumors in Balb C nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. AsPC-1 cells were injected subcutaneously into Balb c nude mice, and tumor-bearing mice were treated with rottlerin. Cell proliferation and apoptosis were measured by Ki67 and TUNEL staining, respectively. The expression of components of Akt, Notch, and Sonic Hedgehog (Shh) pathways were measured by the immunohistochemistry, Western blot analysis, and/or q-RT-PCR. The effects of rottlerin on pancreatic cancer cells isolated from Kras(G12D) mice were also examined. Rottlerin-treated mice showed a significant inhibition in tumor growth which was associated with suppression of cell proliferation, activation of capase-3 and cleavage of PARP. Rottlerin inhibited the expression of Bcl-2, cyclin D1, CDK2 and CDK6, and induced the expression of Bax in tumor tissues compared to untreated control. Rottlerin inhibited the markers of angiogenesis (Cox-2, VEGF, VEGFR, and IL-8), and metastasis (MMP-2 and MMP-9), thus blocking production of tumorigenic mediators in tumor microenvironment. Rottlerin also inhibited epithelial-mesenchymal transition by up-regulating E-cadherin and inhibiting the expression of Slug and Snail. Furthermore, rottlerin treatment of xenografted tumors or pancreatic cancer cells isolated from Kras(G12D) mice showed a significant inhibition in Akt, Shh and Notch pathways compared to control groups. These data suggest that rottlerin can inhibit pancreatic cancer growth by suppressing multiple signaling pathways which are constitutively active in pancreatic cancer. Taken together, our data show that the rottlerin induces apoptosis and inhibits pancreatic cancer growth by targeting Akt, Notch and Shh signaling pathways, and provide a new therapeutic approach with translational potential for humans. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. JF - Cancer letters AU - Huang, Minzhao AU - Tang, Su-Ni AU - Upadhyay, Ghanshyam AU - Marsh, Justin L AU - Jackman, Christopher P AU - Srivastava, Rakesh K AU - Shankar, Sharmila AD - Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. ; Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA. ; Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. Electronic address: rsrivastava.lab@gmail.com. ; Kansas City VA Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA. Electronic address: sharmila.shankar@va.gov. Y1 - 2014/10/10/ PY - 2014 DA - 2014 Oct 10 SP - 32 EP - 40 VL - 353 IS - 1 KW - Acetophenones KW - 0 KW - Angiogenesis Inhibitors KW - Angiogenic Proteins KW - Apoptosis Regulatory Proteins KW - Benzopyrans KW - Hedgehog Proteins KW - Protein Kinase Inhibitors KW - Receptors, Notch KW - SHH protein, human KW - rottlerin KW - E29LP3ZMUH KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Index Medicus KW - Rottlerin KW - Sonic Hedgehog KW - Notch KW - Cancer prevention KW - Pancreatic cancer KW - Akt KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Animals KW - Humans KW - Tumor Microenvironment KW - Cell Line, Tumor KW - Epithelial-Mesenchymal Transition -- drug effects KW - Mice KW - Mice, Nude KW - Mice, Transgenic KW - Angiogenic Proteins -- metabolism KW - Mice, Inbred BALB C KW - Receptors, Notch -- metabolism KW - Hedgehog Proteins -- metabolism KW - Signal Transduction -- drug effects KW - Apoptosis -- drug effects KW - Apoptosis Regulatory Proteins -- metabolism KW - Xenograft Model Antitumor Assays KW - Neovascularization, Pathologic KW - Time Factors KW - Proto-Oncogene Proteins c-akt -- antagonists & inhibitors KW - Receptors, Notch -- antagonists & inhibitors KW - Hedgehog Proteins -- antagonists & inhibitors KW - Genes, ras KW - Cell Proliferation -- drug effects KW - Angiogenesis Inhibitors -- pharmacology KW - Pancreatic Neoplasms -- pathology KW - Pancreatic Neoplasms -- metabolism KW - Protein Kinase Inhibitors -- pharmacology KW - Acetophenones -- pharmacology KW - Tumor Burden -- drug effects KW - Benzopyrans -- pharmacology KW - Pancreatic Neoplasms -- genetics KW - Pancreatic Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1559008780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Rottlerin+suppresses+growth+of+human+pancreatic+tumors+in+nude+mice%2C+and+pancreatic+cancer+cells+isolated+from+Kras%28G12D%29+mice.&rft.au=Huang%2C+Minzhao%3BTang%2C+Su-Ni%3BUpadhyay%2C+Ghanshyam%3BMarsh%2C+Justin+L%3BJackman%2C+Christopher+P%3BSrivastava%2C+Rakesh+K%3BShankar%2C+Sharmila&rft.aulast=Huang&rft.aufirst=Minzhao&rft.date=2014-10-10&rft.volume=353&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=1872-7980&rft_id=info:doi/10.1016%2Fj.canlet.2014.06.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-04 N1 - Date created - 2014-09-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.canlet.2014.06.021 ER - TY - JOUR T1 - Myocardial Atrophy and Chronic Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Assist Device-Induced Myocardial Recovery AN - 1837304046; 21019592 AB - Background In animal models of heterotopic transplantation, mechanical unloading of the normal, nonhypertrophic heart results in atrophy. Primarily on the basis of these animal data, the notion that chronic left ventricular assist device (LVAD)-induced unloading will result in atrophy has dominated the clinical heart failure field, and anti-atrophic drugs have been used to enhance the cardiac recovery potential observed in some LVAD patients. However, whether unloading-induced atrophy in experimental normal heart models applies to failing and hypertrophic myocardium in heart failure patients unloaded by continuous-flow LVADs has not been studied. Objectives The study examined whether mechanical unloading by continuous-flow LVAD leads to myocardial atrophy. Methods We prospectively examined myocardial tissue and hemodynamic and echocardiographic data from 44 LVAD patients and 18 untransplanted normal donors. Results Cardiomyocyte size (cross-sectional area) decreased after LVAD unloading from 1,238 plus or minus 81 mu m2 to 1,011 plus or minus 68 mu m2 (p = 0.001), but not beyond that of normal donor hearts (682 plus or minus 56 mu m2). Electron microscopy ultrastructural evaluation, cardiomyocyte glycogen content, and echocardiographic assessment of myocardial mass and left ventricular function also did not suggest myocardial atrophy. Consistent with these findings, t-tubule morphology, cytoplasmic penetration, and distance from the ryanodine receptor were not indicative of ongoing atrophic remodeling during LVAD unloading. Molecular analysis revealed no up-regulation of proatrophic genes and proteins of the ubiquitin proteasome system. Conclusions Structural, ultrastructural, microstructural, metabolic, molecular, and clinical functional data indicated that prolonged continuous-flow LVAD unloading does not induce hypertrophy regression to the point of atrophy and degeneration. These findings may be useful in designing future investigations that combine LVAD unloading and pharmaceutical therapies as a bridge to recovery of the failing heart. JF - Journal of the American College of Cardiology AU - Diakos, Nikolaos A AU - Selzman, Craig H AU - Sachse, Frank B AU - Stehlik, Josef AU - Kfoury, Abdallah G AU - Wever-Pinzon, Omar AU - Catino, Anna AU - Alharethi, Rami AU - Reid, Bruce B AU - Miller, Dylan V AU - Salama, Mohamed AU - Zaitsev, Alexey V AU - Shibayama, Junko AU - Li, Hui AU - Fang, James C AU - Li, Dean Y AU - Drakos, Stavros G AD - Utah Transplantation Affiliated Hospitals (UTAH) Cardiac Transplant Program: Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health Sciences Center, Intermountain Medical Center, Veterans Administration Salt Lake City Health Care System, Salt Lake City, Utah Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 1602 EP - 1612 PB - Elsevier Science Ltd., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 64 IS - 15 SN - 0735-1097, 0735-1097 KW - Toxicology Abstracts KW - left ventricular assist device KW - mechanical unloading KW - myocardial atrophy KW - ANP atrial natriuretic peptide KW - HF heart failure KW - LV left ventricular KW - LVAD left ventricular assist device KW - PAS periodic acid Schiff KW - PASD periodic acid Schiff with diastase KW - RyR ryanodine receptor KW - UBB ubiquitin KW - UBE2 ubiquitin-conjugating enzyme E2 KW - UPS ubiquitin proteasome system KW - Heart KW - Donors KW - Data processing KW - Mechanical unloading KW - Heart transplantation KW - Animal models KW - Hemodynamics KW - cardiomyocytes KW - Immunosuppressive agents KW - Glycogen KW - Ryanodine receptors KW - Ventricle KW - Allografts KW - Pharmaceuticals KW - Atrophy KW - Degeneration KW - Myocardium KW - Ubiquitin KW - Heart diseases KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837304046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Myocardial+Atrophy+and+Chronic+Mechanical+Unloading+of+the+Failing+Human+Heart%3A+Implications+for+Cardiac+Assist+Device-Induced+Myocardial+Recovery&rft.au=Diakos%2C+Nikolaos+A%3BSelzman%2C+Craig+H%3BSachse%2C+Frank+B%3BStehlik%2C+Josef%3BKfoury%2C+Abdallah+G%3BWever-Pinzon%2C+Omar%3BCatino%2C+Anna%3BAlharethi%2C+Rami%3BReid%2C+Bruce+B%3BMiller%2C+Dylan+V%3BSalama%2C+Mohamed%3BZaitsev%2C+Alexey+V%3BShibayama%2C+Junko%3BLi%2C+Hui%3BFang%2C+James+C%3BLi%2C+Dean+Y%3BDrakos%2C+Stavros+G&rft.aulast=Diakos&rft.aufirst=Nikolaos&rft.date=2014-10-01&rft.volume=64&rft.issue=15&rft.spage=1602&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/10.1016%2Fj.jacc.2014.05.073 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Heart; Donors; Data processing; Mechanical unloading; Animal models; Heart transplantation; Hemodynamics; cardiomyocytes; Immunosuppressive agents; Glycogen; Ventricle; Ryanodine receptors; Allografts; Pharmaceuticals; Degeneration; Atrophy; Heart diseases; Ubiquitin; Myocardium DO - http://dx.doi.org/10.1016/j.jacc.2014.05.073 ER - TY - JOUR T1 - Classes of oppositional-defiant behavior: concurrent and predictive validity AN - 1627730983 AB - Background Oppositional defiant disorder (ODD) has components of both irritability and defiance. It remains unclear whether children with variation in these domains have different adult outcomes. This study examined the concurrent and predictive validity of classes of oppositional defiant behavior. Methods Latent class analysis was performed on the oppositional defiant problems scale of the Child Behavior Checklist in two samples, one in the US (the Achenbach Normative Sample, N = 2029) and one in the Netherlands (the Zuid-Holland Study, N = 2076). A third sample of American children (The Vermont Family Study, N = 399) was examined to determine concurrent validity with DSM diagnoses. Predictive validity over 14 years was assessed using the Zuid-Holland Study. Results Four classes of oppositional defiant problems were consistent in the two latent class analyses: No Symptoms, All Symptoms, Irritable, and Defiant. Individuals in the No Symptoms Class were rarely diagnosed concurrently with ODD or any future disorder. Individuals in the All Symptoms Class had an increased frequency of concurrent childhood diagnosis of ODD and of violence in adulthood. Subjects in the Irritable Class had low concurrent diagnosis of ODD, but increased odds of adult mood disorders. Individuals in the Defiant Class had low concurrent diagnosis of ODD, but had increased odds of violence as adults. Conclusions Only children in the All Symptoms class were likely to have a concurrent diagnosis of ODD. Although not diagnosed with ODD, children in the Irritable Class were more likely to have adult mood disorders and children in the Defiant Class were more likely to engage in violent behavior. JF - Journal of Child Psychology and Psychiatry and Allied Disciplines AU - Althoff, Robert R AU - Kuny-Slock, Ana V AU - Verhulst, Frank C AU - Hudziak, James J AU - Ende, Jan AD - Departments of Psychiatry and Pediatrics, College of Medicine, University of Vermont, Burlington, VT, USA., Department of Psychology, University of Vermont, Burlington, VT, USA., Department of Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands. ; New Mexico Veterans Administration Hospital, Albuquerque, NM, USA. ; Department of Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands. ; Departments of Psychiatry and Pediatrics, College of Medicine, University of Vermont, Burlington, VT, USA., Department of Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands., Department of Medicine, College of Medicine, University of Vermont, Burlington, VT, USA. ; Departments of Psychiatry and Pediatrics, College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Psychology, University of Vermont, Burlington, VT, USA.; Department of Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands. Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 1162 EP - 1171 CY - Cambridge PB - Blackwell Publishing Ltd. VL - 55 IS - 10 SN - 0021-9630 KW - Psychology KW - Adulthood KW - Adults KW - Behaviour KW - Child Behaviour Checklist KW - Affective disorders KW - Childhood KW - Children KW - Defiance KW - Diagnosis KW - Irritability KW - Latent class analysis KW - Only children KW - Oppositional defiant disorder KW - Predictive validity KW - Symptoms KW - Violence KW - United States--US KW - Netherlands KW - Vermont UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627730983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Psychology+and+Psychiatry+and+Allied+Disciplines&rft.atitle=Classes+of+oppositional-defiant+behavior%3A+concurrent+and+predictive+validity&rft.au=Althoff%2C+Robert+R%3BKuny-Slock%2C+Ana+V%3BVerhulst%2C+Frank+C%3BHudziak%2C+James+J%3BEnde%2C+Jan&rft.aulast=Althoff&rft.aufirst=Robert&rft.date=2014-10-01&rft.volume=55&rft.issue=10&rft.spage=1162&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Psychology+and+Psychiatry+and+Allied+Disciplines&rft.issn=00219630&rft_id=info:doi/10.1111%2Fjcpp.12233 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-11-10 N1 - Last updated - 2016-05-12 N1 - SubjectsTermNotLitGenreText - Netherlands; United States--US; Vermont DO - http://dx.doi.org/10.1111/jcpp.12233 ER - TY - JOUR T1 - Positive and negative religious coping, depressive symptoms, and quality of life in people with HIV AN - 1627730004 AB - The present study examined the relationships of positive and negative types of religious coping with depression and quality of life, and the mediating role of benefit finding in the link between religious coping and psychological outcomes among 198 individuals with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). The results of multiple hierarchical analyses revealed that negative religious coping was significantly associated with a high level of depressive symptoms and a low level of quality of life, controlling for demographic and clinical variables. On the other hand, positive religious coping was significantly associated with positive domains of outcome measures such as positive affect and life satisfaction, but not with overall depressive symptoms or quality of life. Tests of mediation analyses showed that benefit finding fully mediated the relationship between positive religious coping and the positive sub-domains of psychological outcomes. The importance of investigating both positive and negative types of religious coping in their relationships with psychological adaptation in people with HIV was discussed, as well as the significance of benefit finding in understanding the link between religious coping and psychological outcomes. JF - Journal of Behavioral Medicine AU - Lee, Minsun AU - Nezu, Arthur M AU - Nezu, Christine Maguth AD - Department of Psychology, Drexel University, Stratton Hall, 3141 Chestnut Street, Philadelphia, PA, 19104, USA minsunlee87@gmail.com; Department of Psychology, Drexel University, Stratton Hall, 3141 Chestnut Street, Philadelphia, PA, 19104, USA, Philadelphia Veterans Administration Medical Center, Philadelphia, PA, USA ; Department of Psychology, Drexel University, Stratton Hall, 3141 Chestnut Street, Philadelphia, PA, 19104, USA Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 921 EP - 930 CY - New York PB - Springer Science & Business Media VL - 37 IS - 5 SN - 0160-7715 KW - Psychology KW - Adaptation KW - AIDS KW - Clinical variables KW - Coping KW - Depression KW - HIV KW - Immune disorders KW - Life satisfaction KW - Mediation KW - Positive affect KW - Quality of life KW - Religious aspects KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627730004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Medicine&rft.atitle=Positive+and+negative+religious+coping%2C+depressive+symptoms%2C+and+quality+of+life+in+people+with+HIV&rft.au=Lee%2C+Minsun%3BNezu%2C+Arthur+M%3BNezu%2C+Christine+Maguth&rft.aulast=Lee&rft.aufirst=Minsun&rft.date=2014-10-01&rft.volume=37&rft.issue=5&rft.spage=921&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Medicine&rft.issn=01607715&rft_id=info:doi/10.1007%2Fs10865-014-9552-y LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright Springer Science & Business Media Oct 2014 N1 - Date revised - 2014-11-10 N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1007/s10865-014-9552-y ER - TY - JOUR T1 - Extensively Drug-Resistant Pseudomonas aeruginosa Isolates Containing blaVIM-2 and Elements of Salmonella Genomic Island 2: a New Genetic Resistance Determinant in Northeast Ohio AN - 1622600568; 20856056 AB - Carbapenems are a mainstay of treatment for infections caused by Pseudomonas aeruginosa. Carbapenem resistance mediated by metallo- beta -lactamases (MBLs) remains uncommon in the United States, despite the worldwide emergence of this group of enzymes. Between March 2012 and May 2013, we detected MBL-producing P. aeruginosa in a university-affiliated health care system in northeast Ohio. We examined the clinical characteristics and outcomes of patients, defined the resistance determinants and structure of the genetic element harboring the blaMBL gene through genome sequencing, and typed MBL-producing P. aeruginosa isolates using pulsed-field gel electrophoresis (PFGE), repetitive sequence-based PCR (rep-PCR), and multilocus sequence typing (MLST). Seven patients were affected that were hospitalized at three community hospitals, a long-term-care facility, and a tertiary care center; one of the patients died as a result of infection. Isolates belonged to sequence type 233 (ST233) and were extensively drug resistant (XDR), including resistance to all fluoroquinolones, aminoglycosides, and beta -lactams; two isolates were nonsusceptible to colistin. The blaMBL gene was identified as blaVIM-2 contained within a class 1 integron (In559), similar to the cassette array previously detected in isolates from Norway, Russia, Taiwan, and Chicago, IL. Genomic sequencing and assembly revealed that In559 was part of a novel 35-kb region that also included a Tn501-like transposon and Salmonella genomic island 2 (SGI2)-homologous sequences. This analysis of XDR strains producing VIM-2 from northeast Ohio revealed a novel recombination event between Salmonella and P. aeruginosa, heralding a new antibiotic resistance threat in this region's health care system. JF - Antimicrobial Agents & Chemotherapy AU - Perez, Federico AU - Hujer, Andrea M AU - Marshall, Steven H AU - Ray, Amy J AU - Rather, Philip N AU - Suwantarat, Nuntra AU - Dumford, Donald III AU - O'Shea, Patrick AU - Domitrovic, T Nicholas J AU - Salata, Robert A AD - Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA, robert.bonomo@va.gov. Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 5929 EP - 5935 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 58 IS - 10 SN - 0066-4804, 0066-4804 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Genomes KW - Metallo- beta -lactamase KW - Fluoroquinolones KW - Drug resistance KW - Enzymes KW - Carbapenems KW - Infection KW - Aminoglycoside antibiotics KW - multilocus sequence typing KW - Transposons KW - Colistin KW - Recombination KW - Islands KW - beta -Lactam antibiotics KW - Pulsed-field gel electrophoresis KW - Polymerase chain reaction KW - genomics KW - Pseudomonas aeruginosa KW - Salmonella KW - Antibiotic resistance KW - Hospitals KW - J 02400:Human Diseases KW - A 01350:Microbial Resistance KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622600568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Extensively+Drug-Resistant+Pseudomonas+aeruginosa+Isolates+Containing+blaVIM-2+and+Elements+of+Salmonella+Genomic+Island+2%3A+a+New+Genetic+Resistance+Determinant+in+Northeast+Ohio&rft.au=Perez%2C+Federico%3BHujer%2C+Andrea+M%3BMarshall%2C+Steven+H%3BRay%2C+Amy+J%3BRather%2C+Philip+N%3BSuwantarat%2C+Nuntra%3BDumford%2C+Donald+III%3BO%27Shea%2C+Patrick%3BDomitrovic%2C+T+Nicholas+J%3BSalata%2C+Robert+A&rft.aulast=Perez&rft.aufirst=Federico&rft.date=2014-10-01&rft.volume=58&rft.issue=10&rft.spage=5929&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.02372-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Number of references - 50 N1 - Last updated - 2015-06-26 N1 - SubjectsTermNotLitGenreText - Genomes; Metallo- beta -lactamase; Fluoroquinolones; Drug resistance; Carbapenems; Enzymes; Infection; Aminoglycoside antibiotics; multilocus sequence typing; Colistin; Transposons; Recombination; Islands; beta -Lactam antibiotics; Pulsed-field gel electrophoresis; Polymerase chain reaction; genomics; Antibiotic resistance; Hospitals; Pseudomonas aeruginosa; Salmonella DO - http://dx.doi.org/10.1128/AAC.02372-14 ER - TY - JOUR T1 - Cyclooxygenases: mediators of UV-induced skin cancer and potential targets for prevention. AN - 1618140029; 24804836 AB - Non-melanoma skin cancers (NMSCs) are among the most common human malignancies. Current methods for their prevention include avoidance of natural and artificial sources of UV radiation and using photoprotective clothing and sunscreens. However, these methods have proven to be inadequate in stemming the rise in skin cancer incidence over the past several years. There is accumulating evidence that cyclooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis, may be involved in the pathogenesis of NMSC. In preclinical studies, animals genetically deficient in the COX-2 enzyme or that have been treated with pharmacological inhibitors of COX-2 develop significantly fewer tumors when subjected to a UV-induced skin carcinogenesis protocol compared with control mice. Several epidemiological studies in humans support the concept that this enzyme is intimately involved in UV-induced skin cancer development, and UV radiation is known to augment COX-2 expression in human skin. Recent studies suggest that drugs that block COX-2 expression may prevent the development of NMSCs. Thus, pharmacologic agents that inhibit the enzyme COX-2 may be effective chemopreventive agents for NMSCs. JF - The Journal of investigative dermatology AU - Elmets, Craig A AU - Ledet, Johnathan J AU - Athar, Mohammad AD - 1] Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA [2] UAB Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA [3] UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA [4] Birmingham Veterans Administration Medical Center, Birmingham, Alabama, USA. ; 1] Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA [2] Birmingham Veterans Administration Medical Center, Birmingham, Alabama, USA. ; 1] Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA [2] UAB Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA [3] UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 2497 EP - 2502 VL - 134 IS - 10 KW - Cyclooxygenase 2 Inhibitors KW - 0 KW - Sunscreening Agents KW - Prostaglandin-Endoperoxide Synthases KW - EC 1.14.99.1 KW - Index Medicus KW - Animals KW - Sunscreening Agents -- therapeutic use KW - Humans KW - Cyclooxygenase 2 Inhibitors -- therapeutic use KW - Cyclooxygenase 2 Inhibitors -- pharmacology KW - Disease Models, Animal KW - Mice KW - Skin Neoplasms -- physiopathology KW - Prostaglandin-Endoperoxide Synthases -- physiology KW - Neoplasms, Radiation-Induced -- physiopathology KW - Skin Neoplasms -- etiology KW - Ultraviolet Rays -- adverse effects KW - Neoplasms, Radiation-Induced -- prevention & control KW - Prostaglandin-Endoperoxide Synthases -- drug effects KW - Skin Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1618140029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=Cyclooxygenases%3A+mediators+of+UV-induced+skin+cancer+and+potential+targets+for+prevention.&rft.au=Elmets%2C+Craig+A%3BLedet%2C+Johnathan+J%3BAthar%2C+Mohammad&rft.aulast=Elmets&rft.aufirst=Craig&rft.date=2014-10-01&rft.volume=134&rft.issue=10&rft.spage=2497&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=1523-1747&rft_id=info:doi/10.1038%2Fjid.2014.192 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-13 N1 - Date created - 2014-09-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Br J Dermatol. 2007 Apr;156(4):716-9 [17493070] Mol Carcinog. 2007 May;46(5):363-71 [17219415] Mol Carcinog. 2007 Aug;46(8):692-8 [17443745] Photochem Photobiol. 2008 Jan-Feb;84(1):10-8 [18173696] Photochem Photobiol. 2008 Mar-Apr;84(2):322-9 [18194346] Circulation. 2008 Apr 22;117(16):2104-13 [18378608] Cancer Prev Res (Phila). 2008 Jun;1(1):32-8 [18841250] Clin Pharmacol Ther. 2009 Feb;85(2):190-7 [18987620] Pharmacoepidemiol Drug Saf. 2009 Apr;18(4):276-83 [19226541] Cancer Prev Res (Phila). 2009 Nov;2(11):951-6 [19892664] Cancer Prev Res (Phila). 2010 Jan;3(1):25-34 [20051370] Arch Dermatol. 2010 Mar;146(3):283-7 [20231499] Arch Dermatol. 2010 Apr;146(4):388-95 [20157019] Pharm Res. 2010 Jun;27(6):1092-102 [20143255] J Natl Cancer Inst. 2010 Dec 15;102(24):1835-44 [21115882] Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6668-73 [21460251] Pharmacoepidemiol Drug Saf. 2011 Sep;20(9):922-9 [21688346] Cancer Prev Res (Phila). 2011 Nov;4(11):1728-35 [21778329] Cancer Metastasis Rev. 2011 Dec;30(3-4):465-80 [22012553] PLoS One. 2012;7(4):e35196 [22496907] Cancer. 2012 Oct 1;118(19):4768-76 [22644960] Dermatol Surg. 2013 Jan;39(1 Pt 1):35-42 [23199014] CA Cancer J Clin. 2013 Jan;63(1):11-30 [23335087] Photodermatol Photoimmunol Photomed. 2013 Apr;29(2):57-64 [23458388] Toxicol Appl Pharmacol. 2013 May 1;268(3):249-55 [23274568] Neoplasia. 2013 Jul;15(7):795-804 [23814491] Cancer Prev Res (Phila). 2013 Jul;6(7):675-85 [23682071] Prostaglandins Other Lipid Mediat. 2000 Oct;62(4):367-84 [11060900] BMJ. 2000 Nov 11;321(7270):1183-7 [11073508] Lancet. 2002 Jan 12;359(9301):118-23 [11809254] Photochem Photobiol. 2002 Jul;76(1):73-80 [12126310] J Drugs Dermatol. 2002 Jul;1(1):44-7 [12847753] Mol Carcinog. 2003 Oct;38(2):49-58 [14502644] Toxicol Appl Pharmacol. 2004 Mar 15;195(3):370-8 [15020200] Cancer Res. 2004 Aug 15;64(16):5587-91 [15313895] J Natl Cancer Inst. 1974 Nov;53(5):1333-6 [4139281] J Immunol. 1986 Oct 15;137(8):2478-84 [3463622] N Engl J Med. 1993 Oct 14;329(16):1147-51 [8377777] Cancer Res. 1998 Feb 1;58(3):409-12 [9458081] Br J Dermatol. 1998 Feb;138(2):301-3 [9602879] Carcinogenesis. 1998 May;19(5):723-9 [9635856] Mol Carcinog. 1999 Aug;25(4):231-40 [10449029] Lancet. 1999 Aug 28;354(9180):723-9 [10475183] Carcinogenesis. 1999 Oct;20(10):1939-44 [10506108] N Engl J Med. 2005 Mar 17;352(11):1071-80 [15713944] JAMA. 2005 Aug 10;294(6):681-90 [16091570] J Am Acad Dermatol. 2005 Dec;53(6):966-72 [16310056] J Invest Dermatol. 2005 Dec;125(6):1317-20 [16354205] J Invest Dermatol. 2006 Jan;126(1):205-11 [16417238] Nat Rev Cancer. 2006 Feb;6(2):130-40 [16491072] Int J Cancer. 2006 Aug 1;119(3):682-6 [16496410] N Engl J Med. 2007 Jul 26;357(4):360-9 [17652651] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/jid.2014.192 ER - TY - JOUR T1 - Rituximab therapy for refractory scleritis: results of a phase I/II dose-ranging, randomized, clinical trial. AN - 1566113653; 24953794 AB - To determine whether rituximab, a monoclonal antibody against the B-lymphocyte antigen CD20, is effective in the treatment of refractory noninfectious scleritis. Prospective, dose-ranging, randomized, double-masked phase I/II clinical trial. Twelve patients with noninfectious scleritis refractory to systemic corticosteroid and ≥1 other systemic immunosuppressive agent were enrolled from January 2007 to March 2010. Subjects were randomly assigned to 500 (n = 5) or 1000 mg (n = 7) dosing arms of rituximab intravenous infusions (500 or 1000 mg), given at study days 1 and 15. Initial responders with breakthrough inflammation after study week 24 were offered treatment with an additional cycle of 2 open-label rituximab 1000 mg infusions. Primary outcomes were reduction of inflammation, as measured with a validated scleritis disease grading scale (SGS) and reduction in corticosteroid dose by ≥50%. Patients were characterized as responders to study therapy if ≥1 of these endpoints showed improvement and neither showed evidence of worsening. Secondary outcomes were improvement in visual acuity, reduction in pain, and improvement in patient and physician-reported global health assessment. Of 12 enrolled patients, 9 met the SGS endpoint at or before week 24, and 4 additionally were able to reduce corticosteroid dose by ≥50%. With regard to secondary outcome measures, 11 and 9 patients showed improvement in patient and physician global health scores, respectively, and 7 patients had reduction in pain. Of 9 initial responders, 7 experienced breakthrough inflammation after 24 weeks and were treated with a second cycle of rituximab infusions. Four patients had significant objective or subjective worsening within 8 weeks of receiving rituximab; this event was averted in subsequent patients by treatment with peri-infusional oral corticosteroid. No other significant adverse events were noted. No differences in efficacy, toxicity, or likelihood of retreatment were noted between the dosing arms. Rituximab was effective treatment for 9 of 12 enrolled patients with refractory, noninfectious scleritis at 24 weeks, although 7 required reinfusion with rituximab to maintain inflammatory control. The treatment was well-tolerated, and peri-infusional inflammatory exacerbations were managed successfully with oral corticosteroids. Further long-term studies are warranted to determine the safety and efficacy of rituximab in treating noninfectious scleritis and other ocular inflammatory diseases. Copyright © 2014 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. JF - Ophthalmology AU - Suhler, Eric B AU - Lim, Lyndell L AU - Beardsley, Robert M AU - Giles, Tracy R AU - Pasadhika, Sirichai AU - Lee, Shelly T AU - de Saint Sardos, Alexandre AU - Butler, Nicholas J AU - Smith, Justine R AU - Rosenbaum, James T AD - Portland Veterans Administration Medical Center, Portland, Oregon; Oregon Health & Science University, Department of Ophthalmology/Casey Eye Institute, Portland, Oregon; Department of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, Oregon. Electronic address: suhlere@ohsu.edu. ; Oregon Health & Science University, Department of Ophthalmology/Casey Eye Institute, Portland, Oregon; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia. ; Oregon Health & Science University, Department of Ophthalmology/Casey Eye Institute, Portland, Oregon. ; Oregon Health & Science University, Department of Ophthalmology/Casey Eye Institute, Portland, Oregon; Department of Developmental Biology, Oregon Health & Science University, Portland, Oregon; Clinical and Molecular Medicine, Flinders University, Adelaide, Australia. ; Oregon Health & Science University, Department of Ophthalmology/Casey Eye Institute, Portland, Oregon; Department of Medicine, and Cell and Developmental Biology, Oregon Health & Science University, Portland, Oregon; Department of Developmental Biology, Oregon Health & Science University, Portland, Oregon; Devers Eye Institute, Portland, Oregon. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 1885 EP - 1891 VL - 121 IS - 10 KW - Antibodies, Monoclonal, Murine-Derived KW - 0 KW - Immunologic Factors KW - Rituximab KW - 4F4X42SYQ6 KW - Index Medicus KW - Severity of Illness Index KW - Young Adult KW - Prospective Studies KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Immunologic Factors -- administration & dosage KW - Antibodies, Monoclonal, Murine-Derived -- administration & dosage KW - Scleritis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566113653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ophthalmology&rft.atitle=Rituximab+therapy+for+refractory+scleritis%3A+results+of+a+phase+I%2FII+dose-ranging%2C+randomized%2C+clinical+trial.&rft.au=Suhler%2C+Eric+B%3BLim%2C+Lyndell+L%3BBeardsley%2C+Robert+M%3BGiles%2C+Tracy+R%3BPasadhika%2C+Sirichai%3BLee%2C+Shelly+T%3Bde+Saint+Sardos%2C+Alexandre%3BButler%2C+Nicholas+J%3BSmith%2C+Justine+R%3BRosenbaum%2C+James+T&rft.aulast=Suhler&rft.aufirst=Eric&rft.date=2014-10-01&rft.volume=121&rft.issue=10&rft.spage=1885&rft.isbn=&rft.btitle=&rft.title=Ophthalmology&rft.issn=1549-4713&rft_id=info:doi/10.1016%2Fj.ophtha.2014.04.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-18 N1 - Date created - 2014-09-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ophtha.2014.04.044 ER - TY - JOUR T1 - Identification of single nucleotide polymorphisms in hematopoietic cell transplant patients affecting early recognition of, and response to, endotoxin. AN - 1562427730; 24107515 AB - Hematopoietic cell transplant (HCT) is a life-saving therapy for many malignant and non-malignant bone marrow diseases. Associated morbidities are often due to transplant-related toxicities and infections, exacerbated by regimen-induced immune suppression and systemic incursion of bacterial products. Patients undergoing myeloablative conditioning for HCT become endotoxemic and display blood/plasma changes consistent with lipopolysaccharide (LPS)-induced systemic innate immune activation. Herein, we addressed whether patients scheduled for HCT display differences in recognition/response to LPS ex vivo traceable to specific single nucleotide polymorphisms (SNPs). Two SNPs of LPS binding protein (LBP) were associated with changes in plasma LBP levels, with one LBP SNP also associating with differences in efficiency of extraction and transfer of endotoxin to myeloid differentiation factor-2 (MD-2), a step needed for activation of TLR4. None of the examined SNPs of CD14, bactericidal/permeability-increasing protein (BPI), TLR4 or MD-2 were associated with corresponding protein plasma levels or endotoxin delivery to MD-2, but CD14 and BPI SNPs significantly associated with differences in LPS-induced TNF-α release ex vivo and infection frequency, respectively. These findings suggest that specific LBP, CD14 and BPI SNPs might be contributory assessments in studies where clinical outcome may be affected by host response to endotoxin and bacterial infection. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav. JF - Innate immunity AU - Guinan, Eva C AU - Palmer, Christine D AU - Mancuso, Christy J AU - Brennan, Lisa AU - Stoler-Barak, Liat AU - Kalish, Leslie A AU - Suter, Eugenie E AU - Gallington, Leighanne C AU - Huhtelin, David P AU - Mansilla, Maria AU - Schumann, Ralf R AU - Murray, Jeffrey C AU - Weiss, Jerrold AU - Levy, Ofer AD - Boston Children's Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA Dana-Farber Cancer Institute, Boston, MA, USA. ; Boston Children's Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Boston, MA, USA. ; Boston Children's Hospital, Boston, MA, USA. ; Dana-Farber Cancer Institute, Boston, MA, USA. ; Boston Children's Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA. ; University of Iowa and Veterans' Administration Medical Center, Coralville, Iowa City, IA, USA. ; Department of Pediatrics, University of Iowa, IA, Iowa City, USA. ; Institute for Microbiology, Charité-University Medical Center, Berlin, Germany. ; Boston Children's Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA ofer.levy@childrens.harvard.edu. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 697 EP - 711 VL - 20 IS - 7 KW - Acute-Phase Proteins KW - 0 KW - Antigens, CD14 KW - Carrier Proteins KW - Chemokines KW - Endotoxins KW - Membrane Glycoproteins KW - Tumor Necrosis Factor-alpha KW - lipopolysaccharide-binding protein KW - Index Medicus KW - bactericidal/permeability-increasing protein (BPI) KW - TNF KW - bone marrow transplant KW - hematopoietic cell transplant (HCT) KW - LPS-binding protein (LBP) KW - lipopolysaccharide (LPS) KW - CD14 KW - Genotype KW - Chemokines -- metabolism KW - Acute-Phase Proteins -- genetics KW - Humans KW - Carrier Proteins -- genetics KW - Cohort Studies KW - Tumor Necrosis Factor-alpha -- metabolism KW - Membrane Glycoproteins -- genetics KW - Antigens, CD14 -- genetics KW - Bone Marrow Diseases -- genetics KW - Hematopoietic Stem Cell Transplantation KW - Bone Marrow Diseases -- therapy KW - Polymorphism, Single Nucleotide -- genetics KW - Endotoxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1562427730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Innate+immunity&rft.atitle=Identification+of+single+nucleotide+polymorphisms+in+hematopoietic+cell+transplant+patients+affecting+early+recognition+of%2C+and+response+to%2C+endotoxin.&rft.au=Guinan%2C+Eva+C%3BPalmer%2C+Christine+D%3BMancuso%2C+Christy+J%3BBrennan%2C+Lisa%3BStoler-Barak%2C+Liat%3BKalish%2C+Leslie+A%3BSuter%2C+Eugenie+E%3BGallington%2C+Leighanne+C%3BHuhtelin%2C+David+P%3BMansilla%2C+Maria%3BSchumann%2C+Ralf+R%3BMurray%2C+Jeffrey+C%3BWeiss%2C+Jerrold%3BLevy%2C+Ofer&rft.aulast=Guinan&rft.aufirst=Eva&rft.date=2014-10-01&rft.volume=20&rft.issue=7&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Innate+immunity&rft.issn=1753-4267&rft_id=info:doi/10.1177%2F1753425913505122 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-22 N1 - Date created - 2014-09-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Endocrinol. 2000 Oct;25(2):169-93 [11013345] Gene. 2013 Jul 1;523(1):70-5 [23562783] J Biol Chem. 2001 Oct 12;276(41):38044-51 [11500507] Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3902-7 [11891303] Transplantation. 2002 May 15;73(9):1522-6 [12023636] Annu Rev Med. 2003;54:29-52 [12359826] Biochem Soc Trans. 2003 Aug;31(Pt 4):785-90 [12887306] J Infect Dis. 2003 Sep 15;188(6):938-43 [12964127] Pediatr Infect Dis J. 2003 Nov;22(11):978-81 [14614371] Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4186-91 [15010525] Mil Med. 2004 Mar;169(3):194-7 [15080238] J Endotoxin Res. 2004;10(2):71-84 [15119998] J Infect Dis. 2004 Aug 1;190(3):527-34 [15243928] Biol Blood Marrow Transplant. 2004 Sep;10(9):635-44 [15319775] Blood. 1992 Dec 15;80(12):2964-8 [1467511] Lancet. 1994 Aug 13;344(8920):429-31 [7520106] Mol Cell Biol. 1996 Jul;16(7):3490-503 [8668165] J Leukoc Biol. 2004 Nov;76(5):909-25 [15292276] J Endotoxin Res. 2005;11(2):69-84 [15949133] J Endotoxin Res. 2005;11(4):225-9 [16176659] Diabetes. 2006 Jan;55(1):216-24 [16380496] Cleft Palate Craniofac J. 2006 Jan;43(1):21-9 [16405370] Hybridoma (Larchmt). 2006 Dec;25(6):349-57 [17203997] J Biol Chem. 2007 Jan 12;282(2):1010-7 [17121827] Immunol Res. 2007;39(1-3):249-60 [17917069] Blood. 2008 Feb 15;111(4):2462-9 [18056482] J Allergy Clin Immunol. 2008 Feb;121(2):434-440.e1 [17949800] J Biol Chem. 2008 Aug 8;283(32):21881-9 [18519568] J Clin Oncol. 2008 Dec 10;26(35):5767-74 [19001324] Hepatology. 2009 Mar;49(3):960-8 [19085953] Expert Rev Anti Infect Ther. 2009 Jun;7(5):607-21 [19485800] J Mol Med (Berl). 2009 Aug;87(8):815-24 [19468702] Crit Care Med. 2009 Oct;37(10):2759-66 [19707138] Curr Opin Gastroenterol. 2010 Mar;26(2):88-94 [20040865] J Immunol. 2010 Apr 15;184(8):4362-7 [20212095] J Allergy Clin Immunol. 2010 Jun;125(6):1361-8 [20398919] Biol Blood Marrow Transplant. 2010 Dec;16(12):1718-27 [20541026] Int Immunol. 2011 Aug;23(8):503-10 [21712422] Biochem Soc Trans. 2011 Aug;39(4):994-9 [21787336] Occup Environ Med. 2011 Nov;68(11):826-31 [21389010] Sci Transl Med. 2011 Nov 23;3(110):110ra118 [22116933] Br J Anaesth. 2012 Mar;108(3):452-9 [22298243] COPD. 2012 Apr;9(2):197-202 [22409502] J Biol Chem. 2012 May 11;287(20):16346-55 [22433852] PLoS One. 2013;8(3):e58164 [23483986] J Biol Chem. 2001 Feb 23;276(8):5883-91 [11084043] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1177/1753425913505122 ER - TY - JOUR T1 - Occupational Therapy Use by Older Adults With Cancer AN - 1679030081 AB - Occupational therapy may significantly improve cancer survivorsʼ ability to participate in activities, thereby improving quality of life. Little is known, however, about the use of occupational therapy services by adults with cancer. The objective of this study was to understand what shapes patterns of occupational therapy use to help improve service delivery. We examined older (age >65 yr) adults diagnosed with breast, prostate, lung, or melanoma (skin) cancer between 2004 and 2007 ( N = 27,131) using North Carolina Central Cancer Registry data linked to Medicare billing claims. Survivors who used occupational therapy within 1 yr before their cancer diagnosis were more likely to use occupational therapy after diagnosis but also experienced the highest levels of comorbidities. Survivors with Stage 4 cancers or lung cancer were less likely to use occupational therapy. These findings suggest possible disparities in utilization of occupational therapy by older adults with cancer. JF - The American Journal of Occupational Therapy AU - Cutchin, Malcolm P AU - Weinberger, Morris AU - Meyer, Anne-Marie AD - Department of Health Care Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI ; Healthcare Quality Management, Department of Health Policy and Management, University of North Carolina at Chapel Hill; Durham Veterans Administration Medical Center, Center for Health Services Research, Durham, NC ; Department of Epidemiology, Gillings School of Global Pubic Health, University of North Carolina at Chapel Hill; Integrated Cancer Information and Surveillance System, University of North Carolina at Chapel Hill ; Pergolotti, Mackenzi; Cancer Care Quality Training Program, Department of Health Policy and Management, Gillings School of Global Public Health, CB#7411, 1102G McGavran-Greenberg Hall, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 Y1 - 2014///Sep/Oct PY - 2014 DA - Sep/Oct 2014 SP - 597 EP - 607 CY - Bethesda PB - American Occupational Therapy Association, Inc. VL - 68 IS - 5 SN - 0272-9490 KW - Medical Sciences KW - Breast cancer KW - Adults KW - Service delivery KW - Skin cancer KW - Skin melanoma KW - Survivors KW - Cancer KW - Charges KW - Diagnosis KW - Elderly people KW - Lung cancer KW - Medicare KW - Occupational therapy KW - Prostate KW - Quality of life KW - North Carolina UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1679030081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Occupational+Therapy&rft.atitle=Occupational+Therapy+Use+by+Older+Adults+With+Cancer&rft.au=Pergolotti%2C+Mackenzi%3BCutchin%2C+Malcolm+P%3BWeinberger%2C+Morris%3BMeyer%2C+Anne-Marie&rft.aulast=Pergolotti&rft.aufirst=Mackenzi&rft.date=2014-09-01&rft.volume=68&rft.issue=5&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Occupational+Therapy&rft.issn=02729490&rft_id=info:doi/10.5014%2Fajot.2014.011791 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-05-05 N1 - Last updated - 2016-05-12 N1 - SubjectsTermNotLitGenreText - North Carolina DO - http://dx.doi.org/10.5014/ajot.2014.011791 ER - TY - JOUR T1 - PARTNERSHIP AND EXTENDED FAMILY RELATIONSHIP QUALITY MODERATE ASSOCIATIONS BETWEEN LIFETIME PSYCHIATRIC DIAGNOSES AND CURRENT DEPRESSIVE SYMPTOMS IN MIDLIFE AN - 1665156385 AB - Adult close relationships, both in marriage and extended family, are hypothesized to be foremost among potential supports and influences on adult development, and the quality of these close relationships has been associated with symptoms of depression and anxiety. In a socioeconomically diverse sample of 182 midlife Black/African American and White/European American men and women, we examined whether close relationship quality moderated the association between lifetime diagnosis of mood and/or anxiety disorder and current symptoms of depression and anxiety. Results supported a buffering hypothesis, such that adults with these lifetime diagnoses and higher quality, supportive, and reciprocal extended family relationships had low depressive symptoms, comparable to those who had no lifetime history of mood/anxiety disorders. Further evidence for a buffering effect of close relationships was seen when both marital and extended family relationships were examined together. When the three risk factors were considered together, that is, lifetime diagnoses, extended family quality, and marital quality, they were additive with respect to predicting depressive symptoms. JF - Journal of Social and Clinical Psychology AU - CROWELL, JUDITH A AU - DEARING, ERIC AU - DAVIS, CYNTHIA R AU - MIRANDA-JULIAN, CLAUDIA AU - BARKAI, AYELET R AU - USHER, NICOLE AU - TRIFILETTI, SARAH AU - MANTZOROS, CHRISTOS AD - Stony Brook University and Judge Baker Childrenʼs Center, Harvard Medical School; Division of Child and Adolescent Psychiatry, Putnam Hall-South Campus, Stony Brook University, Stony Brook, NY 11794 ; Boston College ; Judge Baker Childrenʼs Center, Harvard Medical School ; Tufts University ; Beth Israel Deaconess Medical Center and Harvard Medical School; Boston Veteransʼ Administration Healthcare System ; Stony Brook University and Judge Baker Childrenʼs Center, Harvard Medical School; Division of Child and Adolescent Psychiatry, Putnam Hall-South Campus, Stony Brook University, Stony Brook, NY 11794 Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 612 EP - 629 CY - New York PB - Guilford Publications, Inc. VL - 33 IS - 7 SN - 0736-7236 KW - Psychology KW - Anxiety disorders KW - Adults KW - Anxiety-Depression KW - Black American people KW - Buffering KW - Depression KW - Diagnosis KW - Family relationships KW - Interpersonal relationships KW - Marital quality KW - Marriage KW - Midlife KW - Moderated KW - Quality KW - Risk factors KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665156385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+and+Clinical+Psychology&rft.atitle=PARTNERSHIP+AND+EXTENDED+FAMILY+RELATIONSHIP+QUALITY+MODERATE+ASSOCIATIONS+BETWEEN+LIFETIME+PSYCHIATRIC+DIAGNOSES+AND+CURRENT+DEPRESSIVE+SYMPTOMS+IN+MIDLIFE&rft.au=CROWELL%2C+JUDITH+A%3BDEARING%2C+ERIC%3BDAVIS%2C+CYNTHIA+R%3BMIRANDA-JULIAN%2C+CLAUDIA%3BBARKAI%2C+AYELET+R%3BUSHER%2C+NICOLE%3BTRIFILETTI%2C+SARAH%3BMANTZOROS%2C+CHRISTOS&rft.aulast=CROWELL&rft.aufirst=JUDITH&rft.date=2014-09-01&rft.volume=33&rft.issue=7&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+and+Clinical+Psychology&rft.issn=07367236&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-05-13 ER - TY - JOUR T1 - Hepatitis C treatment eligibility among HIV–hepatitis C virus coinfected patients in Oregon: a population-based sample AN - 1627733768 AB - Approximately 287,000 individuals in the USA are coinfected with HIV and hepatitis C. Recently, new hepatitis C regimens have become available, increasing rates of sustained virologic response in the monoinfected, with studies evaluating their success in the coinfected under way. Previous investigators estimated eligibility for hepatitis C therapy among the coinfected patients, but all had significant methodological limitations. Our study is the first to use a multi-year, statewide, population-based sample to estimate treatment eligibility, and the first to estimate eligibility in the setting of an interferon-free regimen. In a population-based sample of 161 patients infected with HIV and hepatitis C living in Oregon during 2007–2010, 21% were eligible for hepatitis C therapy. Despite the anticipation surrounding an interferon-sparing regimen, eligibility assuming an interferon-free regimen increased only to 26%, largely due to multiple simultaneous contraindications. Obesity was described for the first time as being associated with decreased eligibility (OR: 0.11). Active alcohol abuse was the most common contraindication (24%); uncontrolled mental health (22%), recent injection drug use (21%), poor antiretroviral adherence (22%), and infection (21%) were also common excluding conditions. When active drug or alcohol abuse was excluded as contraindications to therapy, the eligibility rate was 34%, a 62% increase. Assuming an interferon-free regimen and the exclusion of active drug or alcohol abuse as contraindications to therapy, the eligibility rate increased to 42%. Despite the availability of direct-acting anti-viral regimens, eligibility rates in HIV–hepatitis C virus (HCV) coinfection are modest. Many factors precluding hepatitis C therapy are reversible, and targeted interventions could result in increased eligibility. JF - AIDS Care AU - Maier, Marissa M AU - He, Haiou AU - Schafer, Sean D AU - Ward, Thomas T AU - Zaman, Atif AD - Division of Infectious Diseases, Oregon Health and Sciences University, Portland, OR, USA, Program Design and Evaluation Service, Oregon Health Authority, Portland, OR, USA, HIV/STD/TB Program, Oregon Health Authority, Portland, OR, USA, Section of Infectious Diseases, Portland Veterans Administration Medical Center, Portland, OR, USA, Division of Gastroenterology and Hepatology, Oregon Health and Sciences University, Portland, OR, USA ; Division of Infectious Diseases, Oregon Health and Sciences University, Portland, OR, USA; Program Design and Evaluation Service, Oregon Health Authority, Portland, OR, USA; HIV/STD/TB Program, Oregon Health Authority, Portland, OR, USA; Section of Infectious Diseases, Portland Veterans Administration Medical Center, Portland, OR, USA; Division of Gastroenterology and Hepatology, Oregon Health and Sciences University, Portland, OR, USA Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 1178 EP - 1185 CY - London PB - Taylor & Francis Ltd. VL - 26 IS - 9 SN - 0954-0121 KW - Medical Sciences--Psychiatry And Neurology KW - Eligibility KW - Drug abuse KW - Hepatitis KW - Interferon KW - Substance abuse KW - Hepatitis C KW - Alcohol abuse KW - HIV KW - First time KW - Anticipation KW - Adherence KW - Obesity KW - Intravenous drug addiction KW - Mental health KW - Infection KW - Antiretroviral therapy KW - Interventions KW - Reversible KW - Oregon UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627733768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Care&rft.atitle=Hepatitis+C+treatment+eligibility+among+HIV%E2%80%93hepatitis+C+virus+coinfected+patients+in+Oregon%3A+a+population-based+sample&rft.au=Maier%2C+Marissa+M%3BHe%2C+Haiou%3BSchafer%2C+Sean+D%3BWard%2C+Thomas+T%3BZaman%2C+Atif&rft.aulast=Maier&rft.aufirst=Marissa&rft.date=2014-09-01&rft.volume=26&rft.issue=9&rft.spage=1178&rft.isbn=&rft.btitle=&rft.title=AIDS+Care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121.2014.892563 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-10-14 N1 - Last updated - 2016-05-12 N1 - SubjectsTermNotLitGenreText - Oregon DO - http://dx.doi.org/10.1080/09540121.2014.892563 ER - TY - JOUR T1 - Clinical correlates of attentional bias to drug cues associated with cocaine dependence AN - 1627733398 AB - Background and Objective Preoccupation (attentional bias) related to drug-related stimuli has been consistently observed for drug-dependent persons with several studies reporting an association of the magnitude of measured attentional bias with treatment outcomes. The major goal of the present study was to determine if pre-treatment attentional bias to personal drug use reminders in an addiction Stroop task predicts relapse in treatment-seeking, cocaine-dependent subjects. Methods We sought to maximize the potential of attentional bias as a marker of risk for relapse by incorporating individualized rather than generalized drug use cues to reflect the personal conditioned associations that form the incentive motivation properties of drug cues in a sample of cocaine-dependent subjects ( N=35). Results Although a significant group Stroop interference effect was present for drug versus neutral stimuli (ie, attentional bias), the level of attentional bias for cocaine-use words was not predictive of eventual relapse in this sample ( d=.56). A similar lack of prediction power was observed for a non-drug counting word Stroop task as a significant interference effect was detected but did not predict relapse outcomes ( d=.40). Conclusions and Scientific Significance The results of the present study do not provide clear support for the predictive value of individual variation in drug-related attentional bias to forecast probability of relapse in cocaine-dependent men. JF - The American Journal on Addictions AU - Kennedy, Ashley P AU - Gross, Robin E AU - Ely, Tim AU - Drexler, Karen PG AU - Kilts, Clinton D AD - Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia ; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, Atlanta Veteranʼs Administration Medical Center, Atlanta, Georgia ; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, Psychiatric Research Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas ; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 478 EP - 484 CY - Hoboken PB - Wiley Subscription Services, Inc. VL - 23 IS - 5 SN - 1055-0496 KW - Medical Sciences--Psychiatry And Neurology KW - Addiction KW - Men KW - Motivation KW - Power KW - Preoccupation KW - Relapse KW - Reminders KW - Attentional bias KW - Bias KW - Clinical outcomes KW - Cocaine KW - Counting KW - Cues KW - Drug abuse KW - Drug addiction KW - Drug dependency KW - Goals KW - Helpseeking KW - Individualized KW - Interference KW - Magnitude UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627733398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+on+Addictions&rft.atitle=Clinical+correlates+of+attentional+bias+to+drug+cues+associated+with+cocaine+dependence&rft.au=Kennedy%2C+Ashley+P%3BGross%2C+Robin+E%3BEly%2C+Tim%3BDrexler%2C+Karen+PG%3BKilts%2C+Clinton+D&rft.aulast=Kennedy&rft.aufirst=Ashley&rft.date=2014-09-01&rft.volume=23&rft.issue=5&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+on+Addictions&rft.issn=10550496&rft_id=info:doi/10.1111%2Fj.1521-0391.2014.12134.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-10-14 N1 - Last updated - 2016-05-16 DO - http://dx.doi.org/10.1111/j.1521-0391.2014.12134.x ER - TY - JOUR T1 - Bacterial infections in cirrhosis AN - 1566848098; 20759399 AB - Bacterial infections occur in 25-35 % of cirrhotics admitted to hospital. Health-care associated and hospital acquired (nosocomial) infections are the most common epidemiology, with community acquired infections less common (15-30 %). Spontaneous bacterial peritonitis and urinary infections are the most common sites, with spontaneous bacteremia, pneumonia, cellulitis and other sites being less common. The risk of infection is increased among subjects with more severe liver disease and an infection in the past 6 months. Bacteria are isolated from approximately half of patients with a clinical diagnosis of infection. Gram-negative enterobacteriaceae are the most common organisms among community acquired infections; Gram-positive cocci are the most common organisms isolated among subjects with nosocomial infections. Up to 30 % of hospital associated infections are with multidrug resistant bacteria. Consequently, empiric antibiotic therapy that is recommended for community acquired infections is often inadequate for nosocomial infections. Infections worsen liver function. In-hospital and 1-year mortality of cirrhotics with infections is significantly higher than among cirrhotics without infection. In-hospital complications of infections, such as severe sepsis and septic shock, and mortality, are increased among subjects with multidrug-resistant infections as compared with cirrhotics with susceptible bacteria. Short-term antibiotic prophylaxis of cirrhotics with upper gastrointestinal bleeding and long-term antibiotic prophylaxis of selected cirrhotics with spontaneous bacterial peritonitis reduces infections and improves survival. Albumin administration to cirrhotics with SBP and evidence of advanced liver disease improves survival. The benefit of albumin administration to cirrhotics with infections other than SBP is under investigation. JF - Hepatology International AU - Botwin, Gregory J AU - Morgan, Timothy R AD - Gastroenterology Services, VA Long Beach Healthcare Group-11 (GI), VA Long Beach Healthcare System, 5901 E. Seventh Street, Long Beach, CA, 90822, USA, timothy.morgan@va.gov Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 467 EP - 474 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 8 IS - 2 SN - 1936-0533, 1936-0533 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Bacteria KW - Mortality KW - Liver diseases KW - Cirrhosis KW - Drug resistance KW - Peritonitis KW - Survival KW - Bacteremia KW - Antibiotics KW - Septic shock KW - Cellulitis KW - Sepsis KW - Epidemiology KW - Albumin KW - Nosocomial infection KW - Prophylaxis KW - Bleeding KW - Gram-positive cocci KW - Multidrug resistance KW - Enterobacteriaceae KW - Pneumonia KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566848098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+International&rft.atitle=Bacterial+infections+in+cirrhosis&rft.au=Botwin%2C+Gregory+J%3BMorgan%2C+Timothy+R&rft.aulast=Botwin&rft.aufirst=Gregory&rft.date=2014-09-01&rft.volume=8&rft.issue=2&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Hepatology+International&rft.issn=19360533&rft_id=info:doi/10.1007%2Fs12072-014-9522-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 29 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Mortality; Cirrhosis; Liver diseases; Peritonitis; Drug resistance; Bacteremia; Survival; Antibiotics; Septic shock; Sepsis; Cellulitis; Epidemiology; Nosocomial infection; Albumin; Bleeding; Prophylaxis; Gram-positive cocci; Multidrug resistance; Pneumonia; Hospitals; Bacteria; Enterobacteriaceae DO - http://dx.doi.org/10.1007/s12072-014-9522-z ER - TY - JOUR T1 - Identification of Occult Fusobacterium nucleatum Central Nervous System Infection by Use of PCR-Electrospray Ionization Mass Spectrometry AN - 1566847157; 20698460 AB - Anaerobic bacteria are often difficult to detect, especially after the initiation of antibiotics. We describe the application of PCR-electrospray ionization mass spectrometry (PCR/ESI-MS) using a sample of cerebrospinal fluid to identify an anaerobic Gram-negative bacillus, Fusobacterium nucleatum, in a patient with "culture-negative" meningitis and cerebral abscesses. JF - Journal of Clinical Microbiology AU - Nagalingam, Sudha AU - Lisgaris, Michelle AU - Rodriguez, Benigno AU - Jacobs, Michael R AU - Lederman, Michael AU - Salata, Robert A AU - Hujer, Andrea M AU - Muehlenbachs, Atis AU - DeLeon-Carnes, Marlene AU - Farrell, John J AD - Department of Medicine, Division of Infectious Disease and HIV Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA, Robert.bonomo@va.gov. Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 3462 EP - 3464 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 52 IS - 9 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Central nervous system KW - Cerebrospinal fluid KW - Polymerase chain reaction KW - Antibiotics KW - Abscesses KW - Infection KW - Bacillus KW - Fusobacterium nucleatum KW - Mass spectroscopy KW - Meningitis KW - Anaerobic bacteria KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566847157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Identification+of+Occult+Fusobacterium+nucleatum+Central+Nervous+System+Infection+by+Use+of+PCR-Electrospray+Ionization+Mass+Spectrometry&rft.au=Nagalingam%2C+Sudha%3BLisgaris%2C+Michelle%3BRodriguez%2C+Benigno%3BJacobs%2C+Michael+R%3BLederman%2C+Michael%3BSalata%2C+Robert+A%3BHujer%2C+Andrea+M%3BMuehlenbachs%2C+Atis%3BDeLeon-Carnes%2C+Marlene%3BFarrell%2C+John+J&rft.aulast=Nagalingam&rft.aufirst=Sudha&rft.date=2014-09-01&rft.volume=52&rft.issue=9&rft.spage=3462&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.01082-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 8 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Central nervous system; Cerebrospinal fluid; Polymerase chain reaction; Antibiotics; Infection; Abscesses; Mass spectroscopy; Anaerobic bacteria; Meningitis; Bacillus; Fusobacterium nucleatum DO - http://dx.doi.org/10.1128/JCM.01082-14 ER - TY - JOUR T1 - Simultaneous anatomic reconstruction of the acromioclavicular and coracoclavicular ligaments using a single tendon graft AN - 1566831198; 20644130 AB - Purpose: The purpose of this study was to introduce a novel surgical technique for simultaneous anatomic reconstruction of the acromioclavicular and coracoclavicular ligaments using a single tendon graft and to compare its biomechanical characteristics to those of a coracoid cerclage reconstruction of the coracoclavicular ligaments. Methods: Six matched pairs of human acromioclavicular joints with an average age of 54.8 plus or minus 7.8 years were used. One shoulder from each pair received the single tendon acromioclavicular-coracoclavicular reconstruction; the contralateral shoulder received the coracoid cerclage reconstruction. Bovine extensor tendon was used for both techniques. The single tendon acromioclavicular-coracoclavicular reconstruction technique provided anatomic restoration of the two coracoclavicular ligaments and the superior and inferior acromioclavicular ligaments simultaneously using one coracoid hole, one acromion hole, and two clavicular holes with interference screws. Anterior-posterior and superior-inferior translations were quantified for all specimens before and after reconstruction, followed by load to failure testing. Results: Following coracoid cerclage reconstruction, total anterior-posterior translation was significantly greater than intact (10.0 plus or minus 5.7 mm; p = 0.008). Following single tendon acromioclavicular-coracoclavicular reconstruction, there was no significant difference in anterior-posterior translation compared to intact (-1.6 plus or minus 2.2 mm; n.s.). The coracoid cerclage technique demonstrated significantly greater anterior-posterior translation than the single tendon acromioclavicular-coracoclavicular technique (p = 0.007). Both techniques restored superior-inferior translation to the intact condition (n.s.). Ultimate load, deformation at ultimate load, and energy absorbed at ultimate load were significantly greater after acromioclavicular-coracoclavicular reconstruction than after coracoid cerclage reconstruction (p < 0.05). Conclusions: This novel single tendon anatomic acromioclavicular-coracoclavicular reconstruction provided greater stability and stronger load to failure characteristics than the isolated coracoid cerclage reconstruction. A simultaneous acromioclavicular-coracoclavicular reconstruction technique using a single free tendon graft provided anatomic reconstruction of the conoid, trapezoid, and superior and inferior acromioclavicular ligaments and may reduce postoperative subluxation. JF - Knee Surgery, Sports Traumatology, Arthroscopy AU - Shin, Sang-Jin AU - Campbell, Sean AU - Scott, Jonathan AU - McGarry, Michelle H AU - Lee, Thay Q AD - Orthopaedic Biomechanics Laboratory, VA Long Beach Healthcare System (09/151), 5901 East 7th Street, Long Beach, CA, 90822, USA, tqlee@med.va.gov Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 2216 EP - 2222 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 9 SN - 0942-2056, 0942-2056 KW - Physical Education Index KW - Ligaments KW - Surgery KW - Techniques KW - Failure KW - Work load KW - Shoulders KW - Biomechanics (sports techniques) KW - Sports KW - Tendons KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566831198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.atitle=Simultaneous+anatomic+reconstruction+of+the+acromioclavicular+and+coracoclavicular+ligaments+using+a+single+tendon+graft&rft.au=Shin%2C+Sang-Jin%3BCampbell%2C+Sean%3BScott%2C+Jonathan%3BMcGarry%2C+Michelle+H%3BLee%2C+Thay+Q&rft.aulast=Shin&rft.aufirst=Sang-Jin&rft.date=2014-09-01&rft.volume=22&rft.issue=9&rft.spage=2216&rft.isbn=&rft.btitle=&rft.title=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.issn=09422056&rft_id=info:doi/10.1007%2Fs00167-013-2569-x LA - English DB - Physical Education Index N1 - Date revised - 2014-09-01 N1 - Number of references - 22 N1 - Last updated - 2014-10-15 N1 - SubjectsTermNotLitGenreText - Ligaments; Surgery; Failure; Techniques; Shoulders; Work load; Sports; Biomechanics (sports techniques); Tendons DO - http://dx.doi.org/10.1007/s00167-013-2569-x ER - TY - JOUR T1 - The neuroscience of free will: implications for psychiatry AN - 1558993124; 201431247 AB - Belief in free will has been a mainstay in philosophy throughout history, grounded in large part in our intuitive sense that we consciously control our actions and could have done otherwise. However, psychology and psychiatry have long sought to uncover mechanistic explanations for human behavior that challenge the notion of free will. In recent years, neuroscientific discoveries have produced a model of volitional behavior that is at odds with the notion of contra-causal free will and our sense of conscious agency. Volitional behavior instead appears to have antecedents in unconscious brain activity that is localizable to specific neuroanatomical structures. Updating notions of free will in favor of a continuous model of volitional self-control provides a useful paradigm to conceptualize and study some forms of psychopathology such as addiction and impulse control disorders. Similarly, thinking of specific symptoms of schizophrenia as disorders of agency may help to elucidate mechanisms of psychosis. Beyond clinical understanding and etiological research, a neuroscientific model of volitional behavior has the potential to modernize forensic notions of responsibility and criminal punishment in order to inform public policy. Ultimately, moving away from the language of free will towards the language of volitional control may result in an enhanced understanding of the very nature of ourselves. Adapted from the source document. JF - Psychological Medicine AU - Pierre, J M AD - 11301 Wilshire Boulevard, Building 210, Room 15, Los Angeles, CA 90073, USA joseph.pierre2@va.gov Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 2465 EP - 2474 PB - Cambridge University Press, UK VL - 44 IS - 12 SN - 0033-2917, 0033-2917 KW - Schizophrenia KW - Offenders KW - Perception KW - Unconscious KW - Psychiatry KW - Free will KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558993124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=The+neuroscience+of+free+will%3A+implications+for+psychiatry&rft.au=Pierre%2C+J+M&rft.aulast=Pierre&rft.aufirst=J&rft.date=2014-09-01&rft.volume=44&rft.issue=12&rft.spage=2465&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291713002985 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Number of references - 105 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Free will; Perception; Psychiatry; Unconscious; Offenders; Schizophrenia DO - http://dx.doi.org/10.1017/S0033291713002985 ER - TY - JOUR T1 - Hepatitis C treatment eligibility among HIV-Hepatitis C virus coinfected patients in Oregon: a population-based sample AN - 1548776131; 4583139 AB - Approximately 287,000 individuals in the USA are coinfected with HIV and hepatitis C. Recently, new hepatitis C regimens have become available, increasing rates of sustained virologic response in the monoinfected, with studies evaluating their success in the coinfected under way. Previous investigators estimated eligibility for hepatitis C therapy among the coinfected patients, but all had significant methodological limitations. Our study is the first to use a multi-year, statewide, population-based sample to estimate treatment eligibility, and the first to estimate eligibility in the setting of an interferon-free regimen. In a population-based sample of 161 patients infected with HIV and hepatitis C living in Oregon during 2007-2010, 21% were eligible for hepatitis C therapy. Despite the anticipation surrounding an interferon-sparing regimen, eligibility assuming an interferon-free regimen increased only to 26%, largely due to multiple simultaneous contraindications. Obesity was described for the first time as being associated with decreased eligibility (OR: 0.11). Active alcohol abuse was the most common contraindication (24%); uncontrolled mental health (22%), recent injection drug use (21%), poor antiretroviral adherence (22%), and infection (21%) were also common excluding conditions. When active drug or alcohol abuse was excluded as contraindications to therapy, the eligibility rate was 34%, a 62% increase. Assuming an interferon-free regimen and the exclusion of active drug or alcohol abuse as contraindications to therapy, the eligibility rate increased to 42%. Despite the availability of direct- acting anti-viral regimens, eligibility rates in HIV-hepatitis C virus (HCV) coinfection are modest. Many factors precluding hepatitis C therapy are reversible, and targeted interventions could result in increased eligibility. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Maier, Marissa M AU - He, Haiou AU - Schafer, Sean D AU - Ward, Thomas T AU - Zaman, Atif AD - Oregon Health & Sciences University ; Portland Veterans Administration Medical Center Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 1178 EP - 1185 VL - 26 IS - 9 SN - 0954-0121, 0954-0121 KW - Sociology KW - Hepatitis KW - Oregon KW - Alcoholism KW - Mental health KW - Patients KW - Medical treatment KW - U.S.A. KW - HIV KW - Eligibility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1548776131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Hepatitis+C+treatment+eligibility+among+HIV-Hepatitis+C+virus+coinfected+patients+in+Oregon%3A+a+population-based+sample&rft.au=Maier%2C+Marissa+M%3BHe%2C+Haiou%3BSchafer%2C+Sean+D%3BWard%2C+Thomas+T%3BZaman%2C+Atif&rft.aulast=Maier&rft.aufirst=Marissa&rft.date=2014-09-01&rft.volume=26&rft.issue=9&rft.spage=1178&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121.2014.892563 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2014-07-28 N1 - Last updated - 2014-07-29 N1 - SubjectsTermNotLitGenreText - 4176; 5810 3617 6220; 5703 3617 6220; 7890 5792 10484; 9271 7890 5792 10484; 913 561 6220; 7947 5772 7954; 314 433 293 14; 433 293 14 DO - http://dx.doi.org/10.1080/09540121.2014.892563 ER - TY - JOUR T1 - Management of persistent pain in the older patient: a clinical review. AN - 1558525591; 25157726 AB - Persistent pain is highly prevalent, costly, and frequently disabling in later life. To describe barriers to the management of persistent pain among older adults, summarize current management approaches, including pharmacologic and nonpharmacologic modalities; present rehabilitative approaches; and highlight aspects of the patient-physician relationship that can help to improve treatment outcomes. This review is relevant for physicians who seek an age-appropriate approach to delivering pain care for the older adult. Search of MEDLINE and the Cochrane database from January 1990 through May 2014, using the search terms older adults, senior, ages 65 and above, elderly, and aged along with non-cancer pain, chronic pain, persistent pain, pain management, intractable pain, and refractory pain to identify English-language peer-reviewed systematic reviews, meta-analyses, Cochrane reviews, consensus statements, and guidelines relevant to the management of persistent pain in older adults. Of the 92 identified studies, 35 evaluated pharmacologic interventions, whereas 57 examined nonpharmacologic modalities; the majority (n = 50) focused on older adults with osteoarthritis. This evidence base supports a stepwise approach with acetaminophen as first-line therapy. If treatment goals are not met, a trial of a topical nonsteroidal anti-inflammatory drug, tramadol, or both is recommended. Oral nonsteroidal anti-inflammatory drugs are not recommended for long-term use. Careful surveillance to monitor for toxicity and efficacy is critical, given that advancing age increases risk for adverse effects. A multimodal approach is strongly recommended-emphasizing a combination of both pharmacologic and nonpharmacologic treatments to include physical and occupational rehabilitation, as well as cognitive-behavioral and movement-based interventions. An integrated pain management approach is ideally achieved by cultivating a strong therapeutic alliance between the older patient and the physician. Treatment planning for persistent pain in later life requires a clear understanding of the patient's treatment goals and expectations, comorbidities, and cognitive and functional status, as well as coordinating community resources and family support when available. A combination of pharmacologic, nonpharmacologic, and rehabilitative approaches in addition to a strong therapeutic alliance between the patient and physician is essential in setting, adjusting, and achieving realistic goals of therapy. JF - JAMA AU - Makris, Una E AU - Abrams, Robert C AU - Gurland, Barry AU - Reid, M Carrington AD - Department of Internal Medicine, Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, Texas2Department of Medicine, Division of Rheumatology, Veterans Administration Medical Center, Dallas, Texas. ; Department of Psychiatry, Weill Cornell Medical College, New York, New York4Division of Geriatrics and Palliative Medicine, Weill Cornell Medical College, New York, New York. ; Stroud Center, Columbia University, New York, New York. ; Division of Geriatrics and Palliative Medicine, Weill Cornell Medical College, New York, New York. Y1 - 2014/08/27/ PY - 2014 DA - 2014 Aug 27 SP - 825 EP - 836 VL - 312 IS - 8 KW - Analgesics KW - 0 KW - Anti-Inflammatory Agents, Non-Steroidal KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Aged, 80 and over KW - Humans KW - Aged KW - Female KW - Pain Management KW - Chronic Pain -- drug therapy KW - Analgesics -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558525591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Management+of+persistent+pain+in+the+older+patient%3A+a+clinical+review.&rft.au=Makris%2C+Una+E%3BAbrams%2C+Robert+C%3BGurland%2C+Barry%3BReid%2C+M+Carrington&rft.aulast=Makris&rft.aufirst=Una&rft.date=2014-08-27&rft.volume=312&rft.issue=8&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=1538-3598&rft_id=info:doi/10.1001%2Fjama.2014.9405 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-10 N1 - Date created - 2014-08-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Arch Intern Med. 2006 Dec 11-25;166(22):2533-8 [17159021] Clin J Pain. 2007 Jan;23(1 Suppl):S1-43 [17179836] Pain Med. 2007 Jan-Feb;8(1):25-35 [17244101] Pain. 2007 Mar;128(1-2):69-77 [17055167] J Am Geriatr Soc. 2007 May;55(5):780-91 [17493201] Ann Intern 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[24553363] Pain Manag Nurs. 2014 Dec;15(4):760-7 [24144569] Hepatology. 2005 Dec;42(6):1364-72 [16317692] Geriatr Nurs. 1999 May-Jun;20(3):144-6 [10661104] BMJ. 2000 Nov 4;321(7269):1107-11 [11061730] Pain. 2001 Jan;89(2-3):127-34 [11166468] Clin Geriatr Med. 2001 Aug;17(3):417-31, v [11459713] Ann Intern Med. 2001 Dec 18;135(12):1038-46 [11747382] J Gerontol Nurs. 2001 May;27(5):35-41 [11915272] J Am Geriatr Soc. 2002 Jun;50(6 Suppl):S205-24 [12067390] Fam Pract. 2002 Oct;19(5):476-83 [12356698] J Gen Intern Med. 2002 Oct;17(10):766-73 [12390552] J Am Geriatr Soc. 2003 Aug;51(8):1092-8 [12890071] Arch Intern Med. 2003 Nov 10;163(20):2433-45 [14609780] JAMA. 2003 Nov 12;290(18):2428-9 [14612479] Osteoarthritis Cartilage. 2004 Mar;12(3):253-5 [14972343] Ann Rheum Dis. 2004 Aug;63(8):901-7 [15020311] Age Ageing. 2004 Sep;33(5):453-60 [15315918] Pain. 2004 Nov;112(1-2):65-75 [15494186] J Pers Soc Psychol. 1998 Mar;74(3):774-89 [9523419] Arthritis Rheum. 1998 May;41(5):778-99 [9588729] BMJ. 1999 Feb 27;318(7183):593-6 [10037645] Arch Intern Med. 1999 Sep 13;159(16):1931-7 [10493324] Lancet. 1999 Oct 9;354(9186):1248-52 [10520633] BMJ. 2004 Dec 4;329(7478):1317 [15561731] Clin Ther. 2004 Nov;26(11):1774-82 [15639689] Am Fam Physician. 2005 Feb 1;71(3):483-90 [15712623] N Engl J Med. 2005 Mar 31;352(13):1324-34 [15800228] J Clin Pharm Ther. 2005 Apr;30(2):113-20 [15811163] Gerontologist. 2010 Jun;50(3):382-92 [19917645] J Rheumatol. 2010 Jun;37(6):1236-43 [20360183] Pain Med. 2010 Jul;11(7):1063-71 [20642732] J Am Geriatr Soc. 2010 Jul;58(7):1353-69 [20533971] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1001/jama.2014.9405 ER - TY - JOUR T1 - Bile acid flux through portal but not peripheral veins inhibits CYP7A1 expression without involvement of ileal FGF19 in rabbits. AN - 1553708250; 24994853 AB - It was proposed that CYP7A1 expression is suppressed through the gut-hepatic signaling pathway fibroblast growth factor (FGF) 15/19-fibroblast growth factor receptor 4, which is initiated by activation of farnesoid X receptor in the intestine rather than in the liver. The present study tested whether portal bile acid flux alone without ileal FGF19 could downregulate CYP7A1 expression in rabbits. A rabbit model was developed by infusing glycodeoxycholic acid (GDCA) through the splenic vein to bypass ileal FGF19. Study was conducted in four groups of rabbits: control; bile fistula + bovine serum albumin solution perfusion (BF); BF + GDCA (by portal perfusion); and BF + GDCA-f (by femoral perfusion). Compared with only BF, BF + GDCA (6 h portal perfusion) suppressed CYP7A1 mRNA, whereas BF + GDCA-f (via femoral vein) with the same perfusion rate of GDCA did not show inhibitory effects. Meanwhile, there was a decrease in ileal FGF19 expression and portal FGF19 protein levels, but an equivalent increase in biliary bile acid outputs in both GDCA perfusion groups. This study demonstrated that portal bile acid flux alone downregulated CYP7A1 expression with diminished FGF19 expression and protein levels, whereas the same bile acid flux reaching the liver through the hepatic artery via femoral vein had no inhibitory effect on CYP7A1. We propose that bile acid flux through the portal venous system may be a kind of "intestinal factor" that suppresses CYP7A1 expression. Copyright © 2014 the American Physiological Society. JF - American journal of physiology. Gastrointestinal and liver physiology AU - Shang, Quan AU - Guo, Grace L AU - Honda, Akira AU - Shi, Daniel AU - Saumoy, Monica AU - Salen, Gerald AU - Xu, Guorong AD - Department of Medicine, Rutgers, New Jersey Medical School, Newark, New Jersey; Medical Research Service, Veterans Affairs Medical Center, East Orange, New Jersey; ; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey; and. ; Department of Gastroenterology, Ibaraki Medical Center, Tokyo Medical University, Ibaraki, Japan. ; Medical Research Service, Veterans Affairs Medical Center, East Orange, New Jersey; ; Department of Medicine, Rutgers, New Jersey Medical School, Newark, New Jersey; ; Department of Medicine, Rutgers, New Jersey Medical School, Newark, New Jersey; Medical Research Service, Veterans Affairs Medical Center, East Orange, New Jersey; guorong.xu@va.gov. Y1 - 2014/08/15/ PY - 2014 DA - 2014 Aug 15 SP - G479 EP - G486 VL - 307 IS - 4 KW - Glycodeoxycholic Acid KW - 360-65-6 KW - Fibroblast Growth Factors KW - 62031-54-3 KW - Cholesterol 7-alpha-Hydroxylase KW - EC 1.14.14.23 KW - Index Medicus KW - fibroblast growth factor 19 KW - cholesterol 7α-hydroxylase KW - bile acid synthesis KW - Animals KW - Down-Regulation KW - Portal Vein KW - Rabbits KW - Biliary Fistula KW - Fibroblast Growth Factors -- metabolism KW - Glycodeoxycholic Acid -- pharmacology KW - Cholesterol 7-alpha-Hydroxylase -- biosynthesis KW - Ileum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1553708250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.atitle=Bile+acid+flux+through+portal+but+not+peripheral+veins+inhibits+CYP7A1+expression+without+involvement+of+ileal+FGF19+in+rabbits.&rft.au=Shang%2C+Quan%3BGuo%2C+Grace+L%3BHonda%2C+Akira%3BShi%2C+Daniel%3BSaumoy%2C+Monica%3BSalen%2C+Gerald%3BXu%2C+Guorong&rft.aulast=Shang&rft.aufirst=Quan&rft.date=2014-08-15&rft.volume=307&rft.issue=4&rft.spage=G479&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.issn=1522-1547&rft_id=info:doi/10.1152%2Fajpgi.00062.2014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-21 N1 - Date created - 2014-08-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1152/ajpgi.00062.2014 ER - TY - JOUR T1 - Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration. AN - 1562664991; 24792589 AB - The endoplasmic reticulum (ER) is the primary intracellular organelle responsible for protein and lipid biosynthesis, protein folding and trafficking, calcium homeostasis, and several other vital processes in cell physiology. Disturbance in ER function results in ER stress and subsequent activation of the unfolded protein response (UPR). The UPR up-regulates ER chaperones, reduces protein translation, and promotes clearance of cytotoxic misfolded proteins to restore ER homeostasis. If this vital process fails, the cell will be signaled to enter apoptosis, resulting in cell death. Sustained ER stress also can trigger an inflammatory response and exacerbate oxidative stress, both of which contribute synergistically to tissue damage. Studies performed over the past decade have implicated ER stress in a broad range of human diseases, including neurodegenerative diseases, cancer, diabetes, and vascular disorders. Several of these diseases also entail retinal dysfunction and degeneration caused by injury to retinal neurons and/or to the blood vessels that supply retinal cells with nutrients, trophic and homeostatic factors, oxygen, and other essential molecules, as well as serving as a conduit for removal of waste products and potentially toxic substances from the retina. Collectively, such injuries represent the leading cause of blindness world-wide in all age groups. Herein, we summarize recent progress on the study of ER stress and UPR signaling in retinal biology and discuss the molecular mechanisms and the potential clinical applications of targeting ER stress as a new therapeutic approach to prevent and treat neuronal degeneration in the retina. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Experimental eye research AU - Zhang, Sarah X AU - Sanders, Emily AU - Fliesler, Steven J AU - Wang, Joshua J AD - Departments of Ophthalmology and Biochemistry, University at Buffalo, The State University of New York, Buffalo, NY, USA; SUNY Eye Institute, Buffalo, NY, USA. Electronic address: xzhang38@buffalo.edu. ; Department of Medicine, Endocrinology and Diabetes, Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. ; Departments of Ophthalmology and Biochemistry, University at Buffalo, The State University of New York, Buffalo, NY, USA; SUNY Eye Institute, Buffalo, NY, USA; Research Service, Veterans Administration Western New York Healthcare System, Buffalo, NY, USA. ; Departments of Ophthalmology and Biochemistry, University at Buffalo, The State University of New York, Buffalo, NY, USA; SUNY Eye Institute, Buffalo, NY, USA. Y1 - 2014/08// PY - 2014 DA - August 2014 SP - 30 EP - 40 VL - 125 KW - eIF-2 Kinase KW - EC 2.7.11.1 KW - Index Medicus KW - cell death KW - inflammation KW - retinal degeneration KW - unfolded protein response KW - apoptosis KW - endoplasmic reticulum stress KW - Signal Transduction -- physiology KW - Humans KW - eIF-2 Kinase -- physiology KW - Unfolded Protein Response -- physiology KW - Retinal Degeneration -- physiopathology KW - Oxidative Stress -- physiology KW - Endoplasmic Reticulum Stress -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1562664991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+eye+research&rft.atitle=Endoplasmic+reticulum+stress+and+the+unfolded+protein+responses+in+retinal+degeneration.&rft.au=Zhang%2C+Sarah+X%3BSanders%2C+Emily%3BFliesler%2C+Steven+J%3BWang%2C+Joshua+J&rft.aulast=Zhang&rft.aufirst=Sarah&rft.date=2014-08-01&rft.volume=125&rft.issue=&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Experimental+eye+research&rft.issn=1096-0007&rft_id=info:doi/10.1016%2Fj.exer.2014.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-26 N1 - Date created - 2014-08-04 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Exp Med. 2008 May 12;205(5):1227-42 [18458112] Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3224-30 [18378578] Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3437-42 [19211803] FEBS Lett. 2009 May 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Biol. 2007 Jul;8(7):519-29 [17565364] Pflugers Arch. 2007 Aug;454(5):821-47 [17487503] J Neurosci. 2007 Aug 22;27(34):9043-53 [17715341] Dev Cell. 2007 Sep;13(3):365-76 [17765680] Antioxid Redox Signal. 2007 Dec;9(12):2277-93 [17979528] Science. 2008 Jul 25;321(5888):569-72 [18653895] PLoS One. 2008;3(9):e3119 [18769672] Invest Ophthalmol Vis Sci. 2009 Jan;50(1):334-44 [18757512] Nat Rev Immunol. 2008 Sep;8(9):663-74 [18670423] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.exer.2014.04.015 ER - TY - JOUR T1 - Population Structure of KPC-Producing Klebsiella pneumoniae Isolates from Midwestern U.S. Hospitals AN - 1560107210; 20602484 AB - Genome sequencing of carbapenem-resistant Klebsiella pneumoniae isolates from regional U.S. hospitals was used to characterize strain diversity and the blaKPC genetic context. A phylogeny based on core single-nucleotide variants (SNVs) supports a division of sequence type 258 (ST258) into two distinct groups. The primary differences between the groups are in the capsular polysaccharide locus (cps) and their plasmid contents. A strict association between clade and KPC variant was found. The blaKPC gene was found on variants of two plasmid backbones. This study indicates that highly similar K. pneumoniae subpopulations coexist within the same hospitals over time. JF - Antimicrobial Agents & Chemotherapy AU - Wright, Meredith S AU - Perez, Federico AU - Brinkac, Lauren AU - Jacobs, Michael R AU - Kaye, Keith AU - Cober, Eric AU - Duin, David van AU - Marshall, Steven H AU - Hujer, Andrea M AU - Rudin, Susan D AD - J. Craig Venter Institute, La Jolla, California, USA, Robert.Bonomo@va.gov. Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 4961 EP - 4965 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 58 IS - 8 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Genomes KW - Phylogeny KW - Subpopulations KW - Population structure KW - Plasmids KW - Capsular polysaccharides KW - Klebsiella pneumoniae KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560107210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Population+Structure+of+KPC-Producing+Klebsiella+pneumoniae+Isolates+from+Midwestern+U.S.+Hospitals&rft.au=Wright%2C+Meredith+S%3BPerez%2C+Federico%3BBrinkac%2C+Lauren%3BJacobs%2C+Michael+R%3BKaye%2C+Keith%3BCober%2C+Eric%3BDuin%2C+David+van%3BMarshall%2C+Steven+H%3BHujer%2C+Andrea+M%3BRudin%2C+Susan+D&rft.aulast=Wright&rft.aufirst=Meredith&rft.date=2014-08-01&rft.volume=58&rft.issue=8&rft.spage=4961&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00125-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 31 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Phylogeny; Genomes; Subpopulations; Population structure; Plasmids; Capsular polysaccharides; Hospitals; Klebsiella pneumoniae DO - http://dx.doi.org/10.1128/AAC.00125-14 ER - TY - JOUR T1 - Reclaiming the Efficacy of beta -Lactam- beta -Lactamase Inhibitor Combinations: Avibactam Restores the Susceptibility of CMY-2-Producing Escherichia coli to Ceftazidime AN - 1560107131; 20602521 AB - CMY-2 is a plasmid-encoded Ambler class C cephalosporinase that is widely disseminated in Enterobacteriaceae and is responsible for expanded-spectrum cephalosporin resistance. As a result of resistance to both ceftazidime and beta -lactamase inhibitors in strains carrying blaCMY, novel beta -lactam- beta -lactamase inhibitor combinations are sought to combat this significant threat to beta -lactam therapy. Avibactam is a bridged diazabicyclo [3.2.1]octanone non- beta -lactam beta -lactamase inhibitor in clinical development that reversibly inactivates serine beta -lactamases. To define the spectrum of activity of ceftazidime-avibactam, we tested the susceptibilities of Escherichia coli clinical isolates that carry blaCMY-2 or blaCMY-69 and investigated the inactivation kinetics of CMY-2. Our analysis showed that CMY-2-containing clinical isolates of E. coli were highly susceptible to ceftazidime-avibactam (MIC90, less than or equal to 0.5 mg/liter); in comparison, ceftazidime had a MIC90 of >128 mg/liter. More importantly, avibactam was an extremely potent inhibitor of CMY-2 beta -lactamase, as demonstrated by a second-order onset of acylation rate constant (k2/K) of (4.9 plus or minus 0.5) 104 M-1 s-1 and the off-rate constant (koff) of (3.7 plus or minus 0.4) 10-4 s-1. Analysis of the reaction of avibactam with CMY-2 using mass spectrometry to capture reaction intermediates revealed that the CMY-2-avibactam acyl-enzyme complex was stable for as long as 24 h. Molecular modeling studies raise the hypothesis that a series of successive hydrogen-bonding interactions occur as avibactam proceeds through the reaction coordinate with CMY-2 (e.g., T316, G317, S318, T319, S343, N346, and R349). Our findings support the microbiological and biochemical efficacy of ceftazidime-avibactam against E. coli containing plasmid-borne CMY-2 and CMY-69. JF - Antimicrobial Agents & Chemotherapy AU - Papp-Wallace, Krisztina M AU - Winkler, Marisa L AU - Gatta, Julian A AU - Taracila, Magdalena A AU - Chilakala, Sujatha AU - Xu, Yan AU - Johnson, J Kristie AU - Bonomo, Robert A AD - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA, robert.bonomo@va.gov. Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 4290 EP - 4297 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 58 IS - 8 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clinical isolates KW - Molecular modelling KW - Cephalosporins KW - beta -Lactamase KW - Development KW - Acylation KW - Mass spectroscopy KW - Ceftazidime KW - Cephalosporinase KW - Kinetics KW - beta -Lactam antibiotics KW - Escherichia coli KW - Enterobacteriaceae KW - Serine KW - A 01340:Antibiotics & Antimicrobials KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560107131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Reclaiming+the+Efficacy+of+beta+-Lactam-+beta+-Lactamase+Inhibitor+Combinations%3A+Avibactam+Restores+the+Susceptibility+of+CMY-2-Producing+Escherichia+coli+to+Ceftazidime&rft.au=Papp-Wallace%2C+Krisztina+M%3BWinkler%2C+Marisa+L%3BGatta%2C+Julian+A%3BTaracila%2C+Magdalena+A%3BChilakala%2C+Sujatha%3BXu%2C+Yan%3BJohnson%2C+J+Kristie%3BBonomo%2C+Robert+A&rft.aulast=Papp-Wallace&rft.aufirst=Krisztina&rft.date=2014-08-01&rft.volume=58&rft.issue=8&rft.spage=4290&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.02625-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 49 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Ceftazidime; Cephalosporins; Molecular modelling; Cephalosporinase; beta -Lactamase; Kinetics; beta -Lactam antibiotics; Acylation; Development; Serine; Mass spectroscopy; Escherichia coli; Enterobacteriaceae DO - http://dx.doi.org/10.1128/AAC.02625-14 ER - TY - JOUR T1 - Recruitment of septin cytoskeletal proteins by botulinum toxin A protease determines its remarkable stability. AN - 1551026781; 24928902 AB - Proteolytic cleavage of synaptosomal-associated protein 25 by the light chain of botulinum neurotoxin type A (LCA) results in a blockade of neurotransmitter release that persists for several months in motor neurons. The L428A/L429A mutation in LCA is known to significantly shorten both the proteolytic and neuroparalytic effects of the neurotoxin in mice. To elucidate the cellular mechanism for LCA longevity, we studied the effects of L428A/L429A mutation on the interactome, localization and stability of LCA expressed in cultured neuronal cells. Mass spectrometry analysis of the LCA interactome showed that the mutation prevented the interaction of LCA with septins. The wild-type LCA was concentrated in plasma-membrane-associated clusters, colocalizing with septins-2 and septin-7, which accumulated in these clusters only in the presence of LCA. The L428A/L429A mutation decreased co-clustering of LCA and septins and accelerated proteasomal and non-proteasomal degradation of LCA. Similarly, the impairment of septin oligomerization by forchlorfenuron or silencing of septin-2 prevented LCA interaction and clustering with septins and increased LCA degradation. Therefore, the dileucine-mediated LCA-septin co-clustering is crucial for the long-lasting stabilization of LCA-related proteolytic and presumably neuroparalytic activity. © 2014. Published by The Company of Biologists Ltd. JF - Journal of cell science AU - Vagin, Olga AU - Tokhtaeva, Elmira AU - Garay, Patton E AU - Souda, Puneet AU - Bassilian, Sara AU - Whitelegge, Julian P AU - Lewis, Ramilla AU - Sachs, George AU - Wheeler, Larry AU - Aoki, Roger AU - Fernandez-Salas, Ester AD - Department of Physiology, School of Medicine, UCLA and Veterans Administration Greater Los Angeles Health Care System, Los Angeles, CA 91343, USA olgav@ucla.edu. ; Department of Physiology, School of Medicine, UCLA and Veterans Administration Greater Los Angeles Health Care System, Los Angeles, CA 91343, USA. ; Department of Biological Sciences, Allergan Inc., Irvine, CA 92612, USA. ; The NPI-Semel Institute, Pasarow Mass Spectrometry Laboratory, UCLA, Los Angeles, CA 90095, USA. Y1 - 2014/08/01/ PY - 2014 DA - 2014 Aug 01 SP - 3294 EP - 3308 VL - 127 KW - Cell Cycle Proteins KW - 0 KW - Phenylurea Compounds KW - Pyridines KW - RNA, Small Interfering KW - N-(2-chloro-4-pyridyl)-N'-phenylurea KW - 68157-60-8 KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - SEPT7 protein, human KW - EC 3.6.1.- KW - Septins KW - septin 2 protein, human KW - Index Medicus KW - Degradation KW - Botulinum toxin A protease KW - Protein stability KW - Ubiquitylation KW - Septin KW - Animals KW - Protein Transport -- drug effects KW - Humans KW - Protein Multimerization -- drug effects KW - RNA, Small Interfering -- genetics KW - Cell Line, Tumor KW - Mice KW - Cell Cycle Proteins -- metabolism KW - Phenylurea Compounds -- pharmacology KW - Protein Transport -- genetics KW - Cell Cycle Proteins -- genetics KW - Protein Binding -- drug effects KW - Protein Stability -- drug effects KW - Mutation -- genetics KW - Protein Binding -- genetics KW - Pyridines -- pharmacology KW - Septins -- metabolism KW - Neurons -- microbiology KW - Neurons -- physiology KW - Botulinum Toxins, Type A -- metabolism KW - Botulinum Toxins, Type A -- genetics KW - Neurotoxicity Syndromes -- metabolism KW - Cell Membrane -- metabolism KW - Neurotoxicity Syndromes -- microbiology KW - Septins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1551026781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cell+science&rft.atitle=Recruitment+of+septin+cytoskeletal+proteins+by+botulinum+toxin+A+protease+determines+its+remarkable+stability.&rft.au=Vagin%2C+Olga%3BTokhtaeva%2C+Elmira%3BGaray%2C+Patton+E%3BSouda%2C+Puneet%3BBassilian%2C+Sara%3BWhitelegge%2C+Julian+P%3BLewis%2C+Ramilla%3BSachs%2C+George%3BWheeler%2C+Larry%3BAoki%2C+Roger%3BFernandez-Salas%2C+Ester&rft.aulast=Vagin&rft.aufirst=Olga&rft.date=2014-08-01&rft.volume=127&rft.issue=&rft.spage=3294&rft.isbn=&rft.btitle=&rft.title=Journal+of+cell+science&rft.issn=1477-9137&rft_id=info:doi/10.1242%2Fjcs.146324 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-23 N1 - Date created - 2014-08-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1242/jcs.146324 ER - TY - JOUR T1 - Myeloperoxidase in human neutrophil host defence. AN - 1549177421; 24844117 AB - Human neutrophils represent the predominant leucocyte in circulation and the first responder to infection. Concurrent with ingestion of microorganisms, neutrophils activate and assemble the NADPH oxidase at the phagosome, thereby generating superoxide anion and hydrogen peroxide. Concomitantly, granules release their contents into the phagosome, where the antimicrobial proteins and enzymes synergize with oxidants to create an environment toxic to the captured microbe. The most rapid and complete antimicrobial action by human neutrophils against many organisms relies on the combined efforts of the azurophilic granule protein myeloperoxidase and hydrogen peroxide from the NADPH oxidase to oxidize chloride, thereby generating hypochlorous acid and a host of downstream reaction products. Although individual components of the neutrophil antimicrobial response exhibit specific activities in isolation, the situation in the environment of the phagosome is far more complicated, a consequence of multiple and complex interactions among oxidants, proteins and their by-products. In most cases, the cooperative interactions among the phagosomal contents, both from the host and the microbe, culminate in loss of viability of the ingested organism. © 2014 John Wiley & Sons Ltd. JF - Cellular microbiology AU - Nauseef, William M AD - Inflammation Program, Department of Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Veterans Administration Medical Center, Iowa City, IA, 52242, USA. Y1 - 2014/08// PY - 2014 DA - August 2014 SP - 1146 EP - 1155 VL - 16 IS - 8 KW - Hypochlorous Acid KW - 712K4CDC10 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Peroxidase KW - EC 1.11.1.7 KW - Index Medicus KW - Oxidation-Reduction KW - Cytoplasmic Granules -- enzymology KW - Hypochlorous Acid -- metabolism KW - Hydrogen Peroxide -- metabolism KW - Humans KW - Phagocytosis -- physiology KW - Neutrophils -- immunology KW - Phagosomes -- enzymology KW - Peroxidase -- metabolism KW - Neutrophils -- enzymology KW - Phagosomes -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1549177421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+microbiology&rft.atitle=Myeloperoxidase+in+human+neutrophil+host+defence.&rft.au=Nauseef%2C+William+M&rft.aulast=Nauseef&rft.aufirst=William&rft.date=2014-08-01&rft.volume=16&rft.issue=8&rft.spage=1146&rft.isbn=&rft.btitle=&rft.title=Cellular+microbiology&rft.issn=1462-5822&rft_id=info:doi/10.1111%2Fcmi.12312 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-11 N1 - Date created - 2014-07-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Blood. 1975 Dec;46(6):913-9 [173439] J Biol Chem. 1976 Mar 10;251(5):1371-4 [176150] J Clin Invest. 1976 Jul;58(1):50-60 [180060] Infect Immun. 1976 Dec;14(6):1276-83 [12111] Proc Natl Acad Sci U S A. 1977 Oct;74(10):4214-8 [270665] J Clin Invest. 1978 May;61(5):1176-85 [207730] Infect Immun. 1979 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[4275242] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/cmi.12312 ER - TY - JOUR T1 - Paranoid Personality Disorder in the United States: The Role of Race, Illicit Drug Use, and Income AN - 1660020443; 201500720 AB - Differential rates of schizophrenia and paranoia symptoms have been found for Black and White individuals. Paranoid personality disorder shares symptoms with schizophrenia, yet has received minimal attention with regard to potential racial differences. In a sample consisting of 180 substance use disorder treatment-seeking individuals, the association between the diagnosis of paranoid personality disorder and the variables of race, cannabis use disorder, and income were examined. Results extended previous findings to paranoid personality disorder, supporting the hypothesis that Black individuals would be diagnosed with higher rates of paranoid personality disorder. Cannabis use disorder status and income did not predict paranoid personality disorder diagnoses. Adapted from the source document. JF - Journal of Ethnicity in Substance Abuse AU - Raza, Gina T AU - DeMarce, Josephine M AU - Lash, Steven J AU - Parker, Jefferson D AD - Veterans Affairs Medical Center, Salem, Virginia gina.raza@va.gov Y1 - 2014/07// PY - 2014 DA - July 2014 SP - 247 EP - 257 PB - Taylor & Francis, Philadelphia PA VL - 13 IS - 3 SN - 1533-2640, 1533-2640 KW - Schizophrenia KW - Symptoms KW - Black White Relations KW - Paranoia KW - Race KW - Racial Differences KW - Marijuana KW - Income KW - Personality Disorders KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660020443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Ethnicity+in+Substance+Abuse&rft.atitle=Paranoid+Personality+Disorder+in+the+United+States%3A+The+Role+of+Race%2C+Illicit+Drug+Use%2C+and+Income&rft.au=Raza%2C+Gina+T%3BDeMarce%2C+Josephine+M%3BLash%2C+Steven+J%3BParker%2C+Jefferson+D&rft.aulast=Raza&rft.aufirst=Gina&rft.date=2014-07-01&rft.volume=13&rft.issue=3&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Journal+of+Ethnicity+in+Substance+Abuse&rft.issn=15332640&rft_id=info:doi/10.1080%2F15332640.2013.850463 LA - English DB - Social Services Abstracts N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Personality Disorders; Income; Symptoms; Marijuana; Schizophrenia; Race; Racial Differences; Black White Relations; Paranoia DO - http://dx.doi.org/10.1080/15332640.2013.850463 ER - TY - JOUR T1 - Community Fall Prevention Programs: Comparing Three InSTEP Models by Level of Intensity AN - 1560104345; 20555566 AB - The Fall Prevention Center of Excellence designed three progressive-intensity fall prevention program models, Increasing Stability Through Evaluation and Practice (InSTEP), to reduce risk in community-dwelling older adults. Each model included physical activity, medical risk, and home safety components and was implemented as a 12-week program for small class sizes (12-15 people) in community and senior centers. Change in fall rates and fall risk factors was assessed using a battery of performance tests, self-reports of function, and fall diaries in a 3-group within-subjects (N = 200) design measured at baseline, immediately postintervention, and at 3 and 9 months postintervention. Overall, participants experienced a reduction in falls, improved self-perception of gait and balance, and improved dynamic gait function. The medium-intensity InSTEP model significantly (p = .003) reduced self-reported falls in comparison with the other models. InSTEP is a feasible model for addressing fall risk reduction in community-dwelling older adults. JF - Journal of Aging and Physical Activity AU - Kramer, B Josea AU - Creekmur, Beth AU - Mitchell, Michael N AU - Rose, Debra J AU - Pynoos, Jon AU - Rubenstein, Laurence Z AD - Geriatric Research Education Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA, josea.kramer@va.gov Y1 - 2014/07// PY - 2014 DA - Jul 2014 SP - 372 EP - 379 PB - Human Kinetics Publishers, P.O. Box 5076 Champaign IL 61825-5076 United States VL - 22 IS - 3 SN - 1063-8652, 1063-8652 KW - Physical Education Index KW - injury KW - risk reduction KW - older adults KW - Evaluation KW - Programs KW - Home KW - Preventive health KW - Gerontology KW - Exercise KW - Adults KW - Performance KW - Gait KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560104345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aging+and+Physical+Activity&rft.atitle=Community+Fall+Prevention+Programs%3A+Comparing+Three+InSTEP+Models+by+Level+of+Intensity&rft.au=Kramer%2C+B+Josea%3BCreekmur%2C+Beth%3BMitchell%2C+Michael+N%3BRose%2C+Debra+J%3BPynoos%2C+Jon%3BRubenstein%2C+Laurence+Z&rft.aulast=Kramer&rft.aufirst=B&rft.date=2014-07-01&rft.volume=22&rft.issue=3&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aging+and+Physical+Activity&rft.issn=10638652&rft_id=info:doi/10.1123%2FJAPA.2012-0344 LA - English DB - Physical Education Index N1 - Date revised - 2014-09-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Evaluation; Programs; Home; Preventive health; Gerontology; Performance; Adults; Exercise; Gait DO - http://dx.doi.org/10.1123/JAPA.2012-0344 ER - TY - JOUR T1 - Effectiveness of a Psychosocial Weight Management Program for Individuals with Schizophrenia AN - 1558993499; 201430967 AB - The objective of this study was to examine the effectiveness of a weight loss program for individuals with schizophrenia in usual care. The study included 146 adults with schizophrenia from two mental health clinics of the Department of Veterans Affairs. The 109 individuals who were overweight or obese were offered a 16-week, psychosocial, weight management program. Weight and Body Mass Index (BMI) were assessed at baseline, 1 year later, and at each treatment session. Only 51% of those who were overweight or obese chose to enroll in the weight management program. Participants attended an average of 6.7 treatment sessions, lost an average of 2.4 pounds, and had an average BMI decrease of 0.3. There was no significant change in weight or BMI compared to the control group. Intervention strategies that both improve utilization and yield greater weight loss need to be developed. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Niv, Noosha AU - Cohen, Amy N AU - Hamilton, Alison AU - Reist, Christopher AU - Young, Alexander S AD - VA Desert Pacific MIRECC and University of California Los Angeles, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA noosha.niv@va.gov Y1 - 2014/07// PY - 2014 DA - July 2014 SP - 370 EP - 380 PB - Springer, US VL - 41 IS - 3 SN - 1094-3412, 1094-3412 KW - Schizophrenia KW - Obesity KW - Weight loss KW - Clinics KW - Psychosocial factors KW - Body Mass Index KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558993499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Effectiveness+of+a+Psychosocial+Weight+Management+Program+for+Individuals+with+Schizophrenia&rft.au=Niv%2C+Noosha%3BCohen%2C+Amy+N%3BHamilton%2C+Alison%3BReist%2C+Christopher%3BYoung%2C+Alexander+S&rft.aulast=Niv&rft.aufirst=Noosha&rft.date=2014-07-01&rft.volume=41&rft.issue=3&rft.spage=370&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-012-9273-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Number of references - 47 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Weight loss; Body Mass Index; Obesity; Schizophrenia; Psychosocial factors; Clinics DO - http://dx.doi.org/10.1007/s11414-012-9273-3 ER - TY - JOUR T1 - Surveillance of Carbapenem-Resistant Klebsiella pneumoniae: Tracking Molecular Epidemiology and Outcomes through a Regional Network AN - 1547865469; 20207811 AB - Carbapenem resistance in Gram-negative bacteria is on the rise in the United States. A regional network was established to study microbiological and genetic determinants of clinical outcomes in hospitalized patients with carbapenem-resistant (CR) Klebsiella pneumoniae in a prospective, multicenter, observational study. To this end, predefined clinical characteristics and outcomes were recorded and K. pneumoniae isolates were analyzed for strain typing and resistance mechanism determination. In a 14-month period, 251 patients were included. While most of the patients were admitted from long-term care settings, 28% of them were admitted from home. Hospitalizations were prolonged and complicated. Nonsusceptibility to colistin and tigecycline occurred in isolates from 7 and 45% of the patients, respectively. Most of the CR K. pneumoniae isolates belonged to repetitive extragenic palindromic PCR (rep-PCR) types A and B (both sequence type 258) and carried either blaKPC-2 (48%) or blaKPC-3 (51%). One isolate tested positive for blaNDM-1, a sentinel discovery in this region. Important differences between strain types were noted; rep-PCR type B strains were associated with blaKPC-3 (odds ratio [OR], 294; 95% confidence interval [CI], 58 to 2,552; P < 0.001), gentamicin nonsusceptibility (OR, 24; 95% CI, 8.39 to 79.38; P < 0.001), amikacin susceptibility (OR, 11.0; 95% CI, 3.21 to 42.42; P < 0.001), tigecycline nonsusceptibility (OR, 5.34; 95% CI, 1.30 to 36.41; P = 0.018), a shorter length of stay (OR, 0.98; 95% CI, 0.95 to 1.00; P = 0.043), and admission from a skilled-nursing facility (OR, 3.09; 95% CI, 1.26 to 8.08; P = 0.013). Our analysis shows that (i) CR K. pneumoniae is seen primarily in the elderly long-term care population and that (ii) regional monitoring of CR K. pneumoniae reveals insights into molecular characteristics. This work highlights the crucial role of ongoing surveillance of carbapenem resistance determinants. JF - Antimicrobial Agents & Chemotherapy AU - Duin, David van AU - Perez, Federico AU - Rudin, Susan D AU - Cober, Eric AU - Hanrahan, Jennifer AU - Ziegler, Julie AU - Webber, Raymond AU - Fox, Jacqueline AU - Mason, Pamela AU - Richter, Sandra S AD - Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA, robert.bonomo@va.gov. Y1 - 2014/07// PY - 2014 DA - Jul 2014 SP - 4035 EP - 4041 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 58 IS - 7 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Colistin KW - Gentamicin KW - Typing KW - Amikacin KW - Epidemiology KW - tigecycline KW - Gram-negative bacteria KW - Geriatrics KW - Carbapenems KW - Polymerase chain reaction KW - Klebsiella pneumoniae KW - J 02400:Human Diseases KW - A 01350:Microbial Resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1547865469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Surveillance+of+Carbapenem-Resistant+Klebsiella+pneumoniae%3A+Tracking+Molecular+Epidemiology+and+Outcomes+through+a+Regional+Network&rft.au=Duin%2C+David+van%3BPerez%2C+Federico%3BRudin%2C+Susan+D%3BCober%2C+Eric%3BHanrahan%2C+Jennifer%3BZiegler%2C+Julie%3BWebber%2C+Raymond%3BFox%2C+Jacqueline%3BMason%2C+Pamela%3BRichter%2C+Sandra+S&rft.aulast=Duin&rft.aufirst=David&rft.date=2014-07-01&rft.volume=58&rft.issue=7&rft.spage=4035&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.02636-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Number of references - 24 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Gentamicin; Colistin; Typing; Epidemiology; Amikacin; tigecycline; Gram-negative bacteria; Geriatrics; Polymerase chain reaction; Carbapenems; Klebsiella pneumoniae DO - http://dx.doi.org/10.1128/AAC.02636-14 ER - TY - JOUR T1 - Effects of cigarette smoking on metabolism and effectiveness of systemic therapy for lung cancer. AN - 1535630047; 24926542 AB - Cigarette smoke associated polycyclic aromatic hydrocarbons can induce key drug-metabolizing enzymes of cytochrome P450 and isoforms of the glucuronyl transferases families. These enzymes metabolize several systemic therapies for lung cancer. Induction of these enzymes may lead to accelerated clearance with resultant impact on systemic therapy efficacy and toxicity in smokers compared with nonsmokers. This article reviews published literature regarding the influence of smoking as it relates to alteration of metabolism of systemic therapy in lung cancer. A structured search of the National Library of Medicine's PubMed/MEDLINE identified relevant articles. Data were abstracted and analyzed to summarize the findings. Studies that analyzed pharmacokinetic data were prospective. Smokers receiving erlotinib exhibited rapid clearance, requiring a higher dose to reach equivalent systemic exposure compared with nonsmokers. Smokers receiving irinotecan also demonstrated increased clearance and lower systemic exposure. There was no difference in clearance of paclitaxel or docetaxel in smokers. Chemotherapy-associated neutropenia was worse in nonsmokers compared with smokers in patients treated with paclitaxel, docetaxel, irinotecan, and gemcitabine. Systemic therapy for lung cancer has a narrow therapeutic index such that small changes in plasma concentrations or exposure in smokers may result in suboptimal therapy and poor outcomes. Smoking cessation must be emphasized at each clinical visit. However, prospective trials should take into consideration the effects of smoking history on drug pharmacokinetics and efficacy. The metabolizing enzyme phenotype in smokers may require individualized dose algorithms for specific agents. JF - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer AU - O'Malley, Meaghan AU - King, Amanda N AU - Conte, Marisa AU - Ellingrod, Vicki L AU - Ramnath, Nithya AD - *Department of Medicine, Division of Hematology-Oncology; †Taubman Health Sciences Library; ‡College of Pharmacy, University of Michigan; and §The Ann Arbor Veterans Administration Medical Center, Ann Arbor, MI. Y1 - 2014/07// PY - 2014 DA - July 2014 SP - 917 EP - 926 VL - 9 IS - 7 KW - Antineoplastic Agents KW - 0 KW - Polycyclic Aromatic Hydrocarbons KW - Quinazolines KW - Taxoids KW - irinotecan KW - 0H43101T0J KW - Deoxycytidine KW - 0W860991D6 KW - docetaxel KW - 15H5577CQD KW - Nicotine KW - 6M3C89ZY6R KW - gemcitabine KW - B76N6SBZ8R KW - Erlotinib Hydrochloride KW - DA87705X9K KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1A2 KW - Cytochrome P-450 CYP2D6 KW - Cytochrome P-450 CYP3A KW - Paclitaxel KW - P88XT4IS4D KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Taxoids -- pharmacokinetics KW - Quinazolines -- pharmacokinetics KW - Cytochrome P-450 CYP2D6 -- metabolism KW - Paclitaxel -- pharmacokinetics KW - Neutropenia -- etiology KW - Deoxycytidine -- analogs & derivatives KW - Humans KW - Cytochrome P-450 CYP1A2 -- metabolism KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Deoxycytidine -- therapeutic use KW - Paclitaxel -- therapeutic use KW - Taxoids -- therapeutic use KW - Camptothecin -- therapeutic use KW - Camptothecin -- pharmacokinetics KW - Deoxycytidine -- pharmacokinetics KW - Cytochrome P-450 CYP3A -- metabolism KW - Quinazolines -- therapeutic use KW - Camptothecin -- analogs & derivatives KW - Polycyclic Aromatic Hydrocarbons -- metabolism KW - Lung Neoplasms -- enzymology KW - Enzyme Induction -- drug effects KW - Nicotine -- metabolism KW - Antineoplastic Agents -- pharmacokinetics KW - Lung Neoplasms -- drug therapy KW - Smoking -- metabolism KW - Smoking -- adverse effects KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1535630047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.atitle=Effects+of+cigarette+smoking+on+metabolism+and+effectiveness+of+systemic+therapy+for+lung+cancer.&rft.au=O%27Malley%2C+Meaghan%3BKing%2C+Amanda+N%3BConte%2C+Marisa%3BEllingrod%2C+Vicki+L%3BRamnath%2C+Nithya&rft.aulast=O%27Malley&rft.aufirst=Meaghan&rft.date=2014-07-01&rft.volume=9&rft.issue=7&rft.spage=917&rft.isbn=&rft.btitle=&rft.title=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.issn=1556-1380&rft_id=info:doi/10.1097%2FJTO.0000000000000191 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-09 N1 - Date created - 2014-06-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment In: J Thorac Oncol. 2014 Jul;9(7):914-6 [24926541] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/JTO.0000000000000191 ER - TY - JOUR T1 - Arthroscopic Repair of Full-Thickness Rotator Cuff Tears With and Without Acromioplasty: Randomized Prospective Trial With 2-Year Follow-up AN - 1705062292; PQ0001815612 AB - Background: Acromioplasty is commonly performed during arthroscopic rotator cuff repair, but its effect on short-term outcomes is debated. Purpose: To report the short-term clinical outcomes of patients undergoing arthroscopic repair of full-thickness rotator cuff tears with and without acromioplasty. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: Patients undergoing arthroscopic repair of full-thickness rotator cuff tears were randomized into acromioplasty or nonacromioplasty groups. The Simple Shoulder Test (SST), American Shoulder and Elbow Surgeons (ASES) score, Constant score, University of CaliforniaLos Angeles (UCLA) score, and Short Form12 (SF-12) health assessment were collected along with physical examination including range of motion and dynamometer strength testing. Intraoperative data including tear size, repair configuration, and concomitant procedures were recorded. Follow-up examination was performed at regular intervals up to 2 years. Preoperative imaging was reviewed to classify the acromial morphologic type, acromial angle, and lateral acromial angulation. Results: A total of 114 patients were initially enrolled in the study, and 95 (83%; 43 nonacromioplasty, 52 acromioplasty) were available for a minimum 2-year follow-up. There were no significant differences in baseline characteristics, including number of tendons torn, repair configuration, concomitant procedures, and acromion type and angles. Within groups, there was a significant (P < .001) improvement in all functional outcome scores from preoperatively to all follow-up time points, including 2 years, for the nonacromioplasty and acromioplasty groups (ASES score: 55.1-91.5, 48.8-89.0; Constant score: 48.3-75.0, 51.9-78.7, respectively). There were no significant differences in functional outcomes between nonacromioplasty and acromioplasty groups or between subjects with different acromial features at any time point. Conclusion: The results of this study demonstrate no difference in clinical outcomes after rotator cuff repair with or without acromioplasty at 2 years postoperatively. JF - American Journal of Sports Medicine AU - Abrams, Geoffrey D AU - Gupta, Anil K AU - Hussey, Kristen E AU - Tetteh, Elizabeth S AU - Karas, Vasili AU - Bach, Bernard R AU - Cole, Brian J AU - Romeo, Anthony A AU - Verma, Nikhil N AD - Department of Orthopedic Surgery, Stanford University, Stanford, CA, USA, Veterans Administration Palo Alto, Palo Alto, CA, USA,, gabrams@gmail.com Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 1296 EP - 1303 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 42 IS - 6 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - rotator cuff KW - acromioplasty KW - shoulder KW - acromion KW - repair KW - Rotator cuff KW - Sports medicine KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705062292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Arthroscopic+Repair+of+Full-Thickness+Rotator+Cuff+Tears+With+and+Without+Acromioplasty%3A+Randomized+Prospective+Trial+With+2-Year+Follow-up&rft.au=Abrams%2C+Geoffrey+D%3BGupta%2C+Anil+K%3BHussey%2C+Kristen+E%3BTetteh%2C+Elizabeth+S%3BKaras%2C+Vasili%3BBach%2C+Bernard+R%3BCole%2C+Brian+J%3BRomeo%2C+Anthony+A%3BVerma%2C+Nikhil+N&rft.aulast=Abrams&rft.aufirst=Geoffrey&rft.date=2014-06-01&rft.volume=42&rft.issue=6&rft.spage=1296&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F0363546514529091 LA - English DB - Physical Education Index N1 - Date revised - 2015-08-01 N1 - Number of references - 22 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Rotator cuff; Sports medicine DO - http://dx.doi.org/10.1177/0363546514529091 ER - TY - JOUR T1 - Trauma-Informed Care: Keeping Mental Health Settings Safe for Veterans AN - 1665160943 AB - Veterans, as military personnel returning from wars in Afghanistan and Iraq, are frequently coping with various mental health problems. These veterans are at high risk for posttraumatic stress disorder (PTSD) and associated behavioral consequences, including self-harm, verbal and physical aggression, and violence. In this article, we highlight the physiological, physical, and emotional consequences of trauma. We focus on the unique experiences that affect veteransʼ mental health and associated behaviors and advocate for veterans to receive evidenced-based treatment using trauma-informed and recovery-oriented care. JF - Issues in Mental Health Nursing AU - Boyd, Mary Ann AU - Valente, Sharon M AU - Czekanski, Elizabeth AD - Atlanta VAMC, Nursing and Patient Care Services, Decatur, Georgia, and Emory University, Nell; Hodgson Woodruff School of Nursing, Atlanta, Georgia, USA; Veterans Administration, Office of Nursing Service, St. Louis, Missouri, USA; Department of Veterans Affairs, Nursing Research/Education, Los Angeles, California, USA; Veterans Administration, Office of Nursing Service, Washington, DC, and Carlow University,Pittsburgh, Pennsylvania, USA ; Kelly, Ursula; Atlanta VAMC, Nursing and Patient Care Services, Decatur, Georgia, and Emory University, Nell; Hodgson Woodruff School of Nursing, Atlanta, Georgia, USA; Veterans Administration, Office of Nursing Service, St. Louis, Missouri, USA; Department of Veterans Affairs, Nursing Research/Education, Los Angeles, California, USA; Veterans Administration, Office of Nursing Service, Washington, DC, and Carlow University,Pittsburgh, Pennsylvania, USA Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 413 EP - 419 CY - Washington PB - Taylor & Francis Ltd. VL - 35 IS - 6 SN - 0161-2840 KW - Medical Sciences--Psychiatry And Neurology KW - Aggression KW - Posttraumatic stress disorder KW - Psychological trauma KW - Recovery KW - Selfinjury KW - Veterans KW - Violence KW - Wars KW - Coping KW - Health behaviour KW - Health care KW - Health problems KW - High risk KW - Mental health care KW - Mental illness KW - Military personnel KW - Personnel KW - Afghanistan KW - Iraq UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665160943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Issues+in+Mental+Health+Nursing&rft.atitle=Trauma-Informed+Care%3A+Keeping+Mental+Health+Settings+Safe+for+Veterans&rft.au=Kelly%2C+Ursula%3BBoyd%2C+Mary+Ann%3BValente%2C+Sharon+M%3BCzekanski%2C+Elizabeth&rft.aulast=Kelly&rft.aufirst=Ursula&rft.date=2014-06-01&rft.volume=35&rft.issue=6&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Issues+in+Mental+Health+Nursing&rft.issn=01612840&rft_id=info:doi/10.3109%2F01612840.2014.881941 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-09-22 N1 - Last updated - 2016-05-16 N1 - SubjectsTermNotLitGenreText - Afghanistan; Iraq DO - http://dx.doi.org/10.3109/01612840.2014.881941 ER - TY - JOUR T1 - Can Improved Intra- and Inter-team Communication Reduce Missed Delirium? AN - 1558988482; 201428718 AB - To assess the prevalence and the team interaction in cases of missed delirium in acute care veterans coded as not having a diagnosis of delirium in admission or discharge notes. In this retrospective study, the records of 183 hospitalized veterans admitted to the emergency department (ED), medicine, surgery and psychiatry services and coded as not having a diagnosis of delirium were analyzed. Clinical notes of each case were examined using DSM IV TR criteria for delirium. Of the 52 cases assessed to have delirium, 5 cases had been miscoded as not having delirium. In the remaining 47 cases the diagnosis of delirium had been missed. The rates of undiagnosed delirium were ED 46/160, medicine 39/132, surgery 4/17, psychiatry 4/29 and consult liaison (CL) 0/9. Of the 5 cases of delirium identified by the CL service, 2 consult diagnoses were accepted and 3 were rejected. Nursing notes had words suggesting delirium in 70.2 % of 47 cases compared to 41.3 and 43.6 % of the clinician case notes for these patients admitted to ED and medicine respectively. No delirium or cognitive screening scales were utilized in the work up of the 52 cases involving delirium. The study results suggest that continuing education by the CL service of all hospital personnel involved in patient care may improve the diagnosis of delirium. Also, increased clinician-nursing intra-team communication, in addition to careful scrutiny of the nursing and clinician notes may contribute to the reduced incidence of missed delirium. Adapted from the source document. JF - Psychiatric Quarterly AU - Detweiler, Mark B AU - Kenneth, Arline AU - Bader, Geoffrey AU - Sullivan, Kelly AU - Murphy, Pamela F AU - Halling, Mary AU - Kalafat, Naciye AU - Detweiler, Jonna G AD - Salem Veterans Affairs Medical Center, 1970 Roanoke Boulevard, Salem, VA, 24153, USA mark.detweiler1@va.gov Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 211 EP - 224 PB - Springer. New York NY VL - 85 IS - 2 SN - 0033-2720, 0033-2720 KW - Veterans KW - Surgery KW - Nursing KW - Accident and emergency departments KW - Undiagnosed KW - Delirium KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558988482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+Quarterly&rft.atitle=Can+Improved+Intra-+and+Inter-team+Communication+Reduce+Missed+Delirium%3F&rft.au=Detweiler%2C+Mark+B%3BKenneth%2C+Arline%3BBader%2C+Geoffrey%3BSullivan%2C+Kelly%3BMurphy%2C+Pamela+F%3BHalling%2C+Mary%3BKalafat%2C+Naciye%3BDetweiler%2C+Jonna+G&rft.aulast=Detweiler&rft.aufirst=Mark&rft.date=2014-06-01&rft.volume=85&rft.issue=2&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Psychiatric+Quarterly&rft.issn=00332720&rft_id=info:doi/10.1007%2Fs11126-013-9284-0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Number of references - 49 N1 - Last updated - 2016-09-27 N1 - CODEN - PSQUAP N1 - SubjectsTermNotLitGenreText - Delirium; Undiagnosed; Accident and emergency departments; Nursing; Veterans; Surgery DO - http://dx.doi.org/10.1007/s11126-013-9284-0 ER - TY - JOUR T1 - Patient-specific finite element modeling of the Cardiokinetix Parachute super( registered ) device: effects on left ventricular wall stress and function AN - 1534849953; 19976089 AB - The Parachute super( registered ) (Cardiokinetix, Inc., Menlo Park, California) is a catheter-based device intended to reverse left ventricular (LV) remodeling after antero-apical myocardial infarction. When deployed, the device partitions the LV into upper and lower chambers. To simulate its mechanical effects, we created a finite element LV model based on computed tomography (CT) images from a patient before and 6 months after Parachute super( registered ) implantation. Acute mechanical effects were determined by in silico device implantation (VIRTUAL-Parachute). Chronic effects of the device were determined by adjusting the diastolic and systolic material parameters to better match the 6-month post-implantation CT data and LV pressure data at end-diastole (ED) (POST-OP). Regional myofiber stress and pump function were calculated in each case. The principal finding is that VIRTUAL-Parachute was associated with a 61.2 % reduction in the lower chamber myofiber stress at ED. The POST-OP model was associated with a decrease in LV diastolic stiffness and a larger reduction in myofiber stress at the upper (27.1 %) and lower chamber (78.4 %) at ED. Myofiber stress at end-systole and stroke volume was little changed in the POST-OP case. These results suggest that the primary mechanism of Parachute super( registered ) is a reduction in ED myofiber stress, which may reverse eccentric post-infarct LV hypertrophy. JF - Medical & Biological Engineering & Computing AU - Lee, Lik Chuan AU - Ge, Liang AU - Zhang, Zhihong AU - Pease, Matthew AU - Nikolic, Serjan D AU - Mishra, Rakesh AU - Ratcliffe, Mark B AU - Guccione, Julius M AD - Departments of Surgery, University of California, San Francisco, CA, USA, mark.ratcliffe@va.gov Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 557 EP - 566 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 52 IS - 6 SN - 0140-0118, 0140-0118 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Data processing KW - Mathematical models KW - Stroke KW - Stress KW - Myocardial infarction KW - Ventricle KW - Hypertrophy KW - Chronic effects KW - Computed tomography KW - Parks KW - Pressure KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534849953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+%26+Biological+Engineering+%26+Computing&rft.atitle=Patient-specific+finite+element+modeling+of+the+Cardiokinetix+Parachute+super%28+registered+%29+device%3A+effects+on+left+ventricular+wall+stress+and+function&rft.au=Lee%2C+Lik+Chuan%3BGe%2C+Liang%3BZhang%2C+Zhihong%3BPease%2C+Matthew%3BNikolic%2C+Serjan+D%3BMishra%2C+Rakesh%3BRatcliffe%2C+Mark+B%3BGuccione%2C+Julius+M&rft.aulast=Lee&rft.aufirst=Lik&rft.date=2014-06-01&rft.volume=52&rft.issue=6&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=Medical+%26+Biological+Engineering+%26+Computing&rft.issn=01400118&rft_id=info:doi/10.1007%2Fs11517-014-1159-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Number of references - 24 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Heart; Hypertrophy; Ventricle; Mathematical models; Data processing; Chronic effects; Stroke; Computed tomography; Parks; Stress; Pressure; Myocardial infarction DO - http://dx.doi.org/10.1007/s11517-014-1159-5 ER - TY - JOUR T1 - Aerobactin Mediates Virulence and Accounts for Increased Siderophore Production under Iron-Limiting Conditions by Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae AN - 1534835457; 19968475 AB - Hypervirulent (hypermucoviscous) Klebsiella pneumoniae (hvKP) strains are an emerging variant of "classical" K. pneumoniae (cKP) that cause organ and life-threatening infection in healthy individuals. An understanding of hvKP-specific virulence mechanisms that enabled evolution from cKP is limited. Observations by our group and previously published molecular epidemiologic data led us to hypothesize that hvKP strains produced more siderophores than cKP strains and that this trait enhanced hvKP virulence. Quantitative analysis of 12 hvKP strains in iron-poor minimal medium or human ascites fluid showed a significant and distinguishing 6- to 10-fold increase in siderophore production compared to that for 14 cKP strains. Surprisingly, high-pressure liquid chromatography (HPLC)-mass spectrometry and characterization of the hvKP strains hvKP1, A1142, and A1365 and their isogenic aerobactin-deficient ( Delta iucA) derivatives established that aerobactin accounted for the overwhelming majority of increased siderophore production and that this was not due to gene copy number. Further, aerobactin was the primary factor in conditioned medium that enhanced the growth/survival of hvKP1 in human ascites fluid. Importantly the ex vivo growth/survival of hvKP1 Delta iucA was significantly less than that of hvKP1 in human ascites fluid, and the survival of outbred CD1 mice challenged subcutaneously or intraperitoneally with hvKP1 was significantly less than that of mice challenged with hvKP1 Delta iucA. The lowest subcutaneous and intraperitoneal challenge inocula of 3 102 and 3.2 101 CFU, respectively, resulted in 100% mortality, demonstrating the virulence of hvKP1 and its ability to cause infection at a low dose. These data strongly support that aerobactin accounts for increased siderophore production in hvKP compared to cKP (a potential defining trait) and is an important virulence factor. JF - Infection and Immunity AU - Russo, Thomas A AU - Olson, Ruth AU - MacDonald, Ulrike AU - Metzger, Daniel AU - Maltese, Lauren M AU - Drake, Eric J AU - Gulick, Andrew M AD - Veterans Administration Western New York Healthcare System, Buffalo, New York, USA, trusso@acsu.buffalo.edu. Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 2356 EP - 2367 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 6 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - High-performance liquid chromatography KW - Mortality KW - Data processing KW - virulence factors KW - aerobactin KW - Survival KW - Infection KW - copy number KW - Spectrometry KW - Siderophores KW - Virulence KW - Ascites KW - Colony-forming cells KW - Evolution KW - Klebsiella pneumoniae KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534835457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Aerobactin+Mediates+Virulence+and+Accounts+for+Increased+Siderophore+Production+under+Iron-Limiting+Conditions+by+Hypervirulent+%28Hypermucoviscous%29+Klebsiella+pneumoniae&rft.au=Russo%2C+Thomas+A%3BOlson%2C+Ruth%3BMacDonald%2C+Ulrike%3BMetzger%2C+Daniel%3BMaltese%2C+Lauren+M%3BDrake%2C+Eric+J%3BGulick%2C+Andrew+M&rft.aulast=Russo&rft.aufirst=Thomas&rft.date=2014-06-01&rft.volume=82&rft.issue=6&rft.spage=2356&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01667-13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Number of references - 55 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Mortality; Data processing; aerobactin; virulence factors; Survival; Infection; Siderophores; Spectrometry; copy number; Virulence; Ascites; Colony-forming cells; Evolution; Klebsiella pneumoniae DO - http://dx.doi.org/10.1128/IAI.01667-13 ER - TY - CPAPER T1 - Psychological and Physiological Acoustics: Investigating the auditory system and its responses to sound T2 - 167th Meeting of the Acoustical Society of America AN - 1548628468; 6291133 JF - 167th Meeting of the Acoustical Society of America AU - Gallun, Frederick Y1 - 2014/05/05/ PY - 2014 DA - 2014 May 05 KW - Auditory system KW - Psychology KW - Acoustics KW - Physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1548628468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=167th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Psychological+and+Physiological+Acoustics%3A+Investigating+the+auditory+system+and+its+responses+to+sound&rft.au=Gallun%2C+Frederick&rft.aulast=Gallun&rft.aufirst=Frederick&rft.date=2014-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=167th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://acousticalsociety.org/sites/default/files/docs/fullprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-30 N1 - Last updated - 2014-07-28 ER - TY - CPAPER T1 - Future directions in psychoacoustic research facilities T2 - 167th Meeting of the Acoustical Society of America AN - 1548628164; 6291406 JF - 167th Meeting of the Acoustical Society of America AU - Gordon, Samuel AU - Ellingson, Roger Y1 - 2014/05/05/ PY - 2014 DA - 2014 May 05 KW - Acoustics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1548628164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=167th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Future+directions+in+psychoacoustic+research+facilities&rft.au=Gordon%2C+Samuel%3BEllingson%2C+Roger&rft.aulast=Gordon&rft.aufirst=Samuel&rft.date=2014-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=167th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://acousticalsociety.org/sites/default/files/docs/fullprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-30 N1 - Last updated - 2014-07-28 ER - TY - CPAPER T1 - A tutorial on psychoacoustical approaches relevant to listening in rooms T2 - 167th Meeting of the Acoustical Society of America AN - 1548628124; 6291623 JF - 167th Meeting of the Acoustical Society of America AU - Gallun, Frederick Y1 - 2014/05/05/ PY - 2014 DA - 2014 May 05 KW - Acoustics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1548628124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=167th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=A+tutorial+on+psychoacoustical+approaches+relevant+to+listening+in+rooms&rft.au=Gallun%2C+Frederick&rft.aulast=Gallun&rft.aufirst=Frederick&rft.date=2014-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=167th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://acousticalsociety.org/sites/default/files/docs/fullprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-30 N1 - Last updated - 2014-07-28 ER - TY - JOUR T1 - Clinical Significance and Characterization of Haemophilus influenzae Type b Genogroup Isolates from Urine Samples in an Adult Male Population AN - 1529932075; 19798203 AB - The occurrence and significance of Haemophilus spp. isolated from the genitourinary tract are not well known. Herein, we describe the clinical significance and characteristics of Haemophilus influenzae type b genogroup strains isolated from genitourinary tract specimens from an adult male veteran patient population and, in particular, their associations with prostatitis and epididymitis. JF - Journal of Clinical Microbiology AU - Dingle, Tanis C AU - Clarridge, Jill E, III AD - Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA, jill.clarridge@va.gov. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 1745 EP - 1748 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 52 IS - 5 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - Prostatitis KW - Haemophilus influenzae KW - Urine KW - Males KW - Epididymitis KW - Genitourinary tract KW - J 02400:Human Diseases KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1529932075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Clinical+Significance+and+Characterization+of+Haemophilus+influenzae+Type+b+Genogroup+Isolates+from+Urine+Samples+in+an+Adult+Male+Population&rft.au=Dingle%2C+Tanis+C%3BClarridge%2C+Jill+E%2C+III&rft.aulast=Dingle&rft.aufirst=Tanis&rft.date=2014-05-01&rft.volume=52&rft.issue=5&rft.spage=1745&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00506-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Number of references - 20 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Prostatitis; Urine; Epididymitis; Genitourinary tract; Males; Haemophilus influenzae DO - http://dx.doi.org/10.1128/JCM.00506-14 ER - TY - JOUR T1 - Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis. AN - 1519846618; 24508063 AB - Epithelial-mesenchymal transition (EMT), a critical step in the acquisition of metastatic state, is an attractive target for therapeutic interventions directed against tumor metastasis. Honokiol (HNK) is a natural phenolic compound isolated from an extract of seed cones from Magnolia grandiflora. Recent studies from our lab show that HNK impedes breast carcinogenesis. Here, we provide molecular evidence that HNK inhibits EMT in breast cancer cells resulting in significant downregulation of mesenchymal marker proteins and concurrent upregulation of epithelial markers. Experimental EMT induced by exposure to TGFβ and TNFα in spontaneously immortalized nontumorigenic human mammary epithelial cells is also completely reversed by HNK as evidenced by morphological as well as molecular changes. Investigating the downstream mediator(s) that may direct EMT inhibition by HNK, we found functional interactions between HNK, Stat3, and EMT-signaling components. In vitro and in vivo analyses show that HNK inhibits Stat3 activation in breast cancer cells and tumors. Constitutive activation of Stat3 abrogates HNK-mediated activation of epithelial markers whereas inhibition of Stat3 using small molecule inhibitor, Stattic, potentiates HNK-mediated inhibition of EMT markers, invasion and migration of breast cancer cells. Mechanistically, HNK inhibits recruitment of Stat3 on mesenchymal transcription factor Zeb1 promoter resulting in decreased Zeb1 expression and nuclear translocation. We also discover that HNK increases E-cadherin expression via Stat3-mediated release of Zeb1 from E-cadherin promoter. Collectively, this study reports that HNK effectively inhibits EMT in breast cancer cells and provide evidence for a previously unrecognized cross-talk between HNK and Stat3/Zeb1/E-cadherin axis. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. JF - Molecular oncology AU - Avtanski, Dimiter B AU - Nagalingam, Arumugam AU - Bonner, Michael Y AU - Arbiser, Jack L AU - Saxena, Neeraj K AU - Sharma, Dipali AD - Department of Oncology, Johns Hopkins University School of Medicine, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA. ; Department of Dermatology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA. ; Department of Dermatology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA; Atlanta Veterans Administration Medical Center, Atlanta, GA 30322, USA. ; Department of Medicine, University of Maryland School of Medicine, 660 W Redwood St., Howard Hall, Rm 301, Baltimore, MD 21201, USA. Electronic address: nsaxena@medicine.umaryland.edu. ; Department of Oncology, Johns Hopkins University School of Medicine, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA. Electronic address: dsharma7@jhmi.edu. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 565 EP - 580 VL - 8 IS - 3 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Biphenyl Compounds KW - Cadherins KW - Homeodomain Proteins KW - Lignans KW - STAT3 Transcription Factor KW - Transcription Factors KW - ZEB1 protein, human KW - Zinc Finger E-box-Binding Homeobox 1 KW - honokiol KW - 11513CCO0N KW - Index Medicus KW - Zeb1 KW - Honokiol KW - Breast cancer KW - Stat3 KW - EMT KW - E-cadherin KW - Humans KW - Signal Transduction -- drug effects KW - Breast -- drug effects KW - Magnolia -- chemistry KW - Cell Line, Tumor KW - Female KW - Breast -- metabolism KW - Breast Neoplasms -- drug therapy KW - Antineoplastic Agents, Phytogenic -- isolation & purification KW - STAT3 Transcription Factor -- antagonists & inhibitors KW - Cadherins -- metabolism KW - Transcription Factors -- metabolism KW - Lignans -- isolation & purification KW - Lignans -- pharmacology KW - Antineoplastic Agents, Phytogenic -- pharmacology KW - Biphenyl Compounds -- pharmacology KW - Breast Neoplasms -- metabolism KW - Epithelial-Mesenchymal Transition -- drug effects KW - Homeodomain Proteins -- metabolism KW - Biphenyl Compounds -- isolation & purification KW - STAT3 Transcription Factor -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519846618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+oncology&rft.atitle=Honokiol+inhibits+epithelial-mesenchymal+transition+in+breast+cancer+cells+by+targeting+signal+transducer+and+activator+of+transcription+3%2FZeb1%2FE-cadherin+axis.&rft.au=Avtanski%2C+Dimiter+B%3BNagalingam%2C+Arumugam%3BBonner%2C+Michael+Y%3BArbiser%2C+Jack+L%3BSaxena%2C+Neeraj+K%3BSharma%2C+Dipali&rft.aulast=Avtanski&rft.aufirst=Dimiter&rft.date=2014-05-01&rft.volume=8&rft.issue=3&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Molecular+oncology&rft.issn=1878-0261&rft_id=info:doi/10.1016%2Fj.molonc.2014.01.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-17 N1 - Date created - 2014-04-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Free Radic Biol Med. 2008 Jun 15;44(12):2043-50 [18423412] Cell Stem Cell. 2008 Jun 5;2(6):511-2 [18522839] PLoS One. 2008;3(8):e2888 [18682804] Acta Pharmacol Sin. 2008 Sep;29(9):1060-8 [18718175] Lung Cancer. 2008 Oct;62(1):8-14 [18372076] Expert Opin Investig Drugs. 2009 Jan;18(1):45-56 [19053881] Int J Biochem Cell Biol. 2009 May;41(5):1034-45 [18930836] Cancer Metastasis Rev. 2009 Jun;28(1-2):151-66 [19153669] Cancer Res. 2009 Apr 1;69(7):2887-95 [19276366] Chem Biol Interact. 2009 Aug 14;180(3):506-14 [19539808] Oncogene. 2009 Jul 23;28(29):2621-33 [19483724] Cell. 2009 Aug 7;138(3):592-603 [19665978] Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13820-5 [19666588] BMC Cancer. 2009;9:325 [19751508] Cell. 2009 Nov 25;139(5):871-90 [19945376] Antioxid Redox Signal. 2009 May;11(5):1139-48 [19203212] Breast Cancer Res. 2009;11(6):213 [19909494] Curr Med Chem. 2010;17(3):190-7 [20214562] J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):253-60 [20354771] J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):235-52 [20521089] Gastroenterology. 2010 Nov;139(5):1762-73, 1773.e1-5 [20637208] Hepatology. 2010 Nov;52(5):1713-22 [20941777] Carcinogenesis. 2011 Mar;32(3):359-67 [21163886] PLoS One. 2011;6(4):e18490 [21559510] PLoS One. 2011;6(6):e21573 [21720559] Cancer Prev Res (Phila). 2011 Jul;4(7):1107-17 [21464039] J Clin Invest. 2011 Jul;121(7):2723-35 [21633165] Brain Res Bull. 2012 Feb 10;87(2-3):144-53 [22155297] Hum Pathol. 2012 Mar;43(3):364-73 [21835433] J Biol Chem. 2012 Feb 17;287(8):5819-32 [22205702] Breast Cancer Res. 2012;14(1):202 [22264257] Breast Cancer Res. 2012;14(1):R35 [22353783] Epigenetics. 2013 Jan;8(1):54-65 [23221619] PLoS One. 2013;8(4):e60749 [23580348] Curr Mol Med. 2012 Dec;12(10):1244-52 [22834827] Oncogene. 2000 May 15;19(21):2474-88 [10851046] Oncogene. 2000 Nov 16;19(48):5419-27 [11114718] Oncogene. 2000 Dec 27;19(56):6613-26 [11426647] Int J Oncol. 2001 Dec;19(6):1155-60 [11713584] Planta Med. 2001 Nov;67(8):705-8 [11731909] Clin Cancer Res. 2002 Apr;8(4):945-54 [11948098] Biochem Pharmacol. 2002 May 1;63(9):1641-51 [12007567] Mol Cancer Ther. 2002 Sep;1(11):893-9 [12481410] Mol Biol Cell. 2003 May;14(5):1790-800 [12802055] J Biol Chem. 2003 Sep 12;278(37):35501-7 [12816951] Nat Rev Cancer. 2004 Feb;4(2):97-105 [14964307] Mol Cancer Ther. 2004 Feb;3(2):149-59 [14985455] World J Gastroenterol. 2004 Aug 1;10(15):2205-8 [15259066] J Clin Invest. 2004 Aug;114(4):569-81 [15314694] Expert Opin Ther Targets. 2004 Oct;8(5):409-22 [15469392] Yakugaku Zasshi. 1973 Apr;93(4):429-34 [4738511] Biochem Pharmacol. 1994 Feb 9;47(3):549-53 [8117323] Life Sci. 1994;55(13):1061-9 [8084211] Nature. 1996 Feb 15;379(6566):645-8 [8628398] J Clin Invest. 1998 Oct 1;102(7):1385-92 [9769331] Int J Mol Med. 1998 Dec;2(6):671-3 [9850734] Immunity. 1999 Jan;10(1):105-15 [10023775] Cell. 1999 Aug 6;98(3):295-303 [10458605] Oncogene. 2005 Feb 3;24(6):970-9 [15592503] Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4700-5 [15781862] Am J Pathol. 2005 May;166(5):1321-32 [15855634] Planta Med. 2005 Apr;71(4):338-43 [15856410] Blood. 2005 Jul 15;106(2):690-7 [15802533] Blood. 2005 Sep 1;106(5):1794-800 [15870175] Neuropharmacology. 2005 Sep;49(4):542-50 [15921707] Biochem Pharmacol. 2005 Nov 15;70(10):1443-57 [16181613] Nat Clin Pract Oncol. 2005 Jun;2(6):315-24 [16264989] Cancer Res. 2006 Jun 15;66(12):6370-8 [16778215] Mol Cancer Res. 2006 Sep;4(9):621-33 [16966432] Carcinogenesis. 2006 Nov;27(11):2180-9 [16675472] Oncogene. 2007 Feb 1;26(5):711-24 [16862183] Cancer Res. 2007 Mar 15;67(6):2497-507 [17363567] Cancer. 2007 Apr 1;109(7):1279-89 [17326044] J Biol Chem. 2007 May 4;282(18):13316-25 [17344214] Cancer Res. 2007 Dec 15;67(24):11742-50 [18089804] Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):715-25 [18093712] Biochem Biophys Res Commun. 2008 May 16;369(4):1098-102 [18331824] Cell. 2008 May 16;133(4):704-15 [18485877] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.molonc.2014.01.004 ER - TY - JOUR T1 - Combat exposure severity as a moderator of genetic and environmental liability to post-traumatic stress disorder AN - 1516740617; 19544395 AB - Twin studies of veterans and adults suggest that approximately 30-46% of the variance in post-traumatic stress disorder (PTSD) is attributable to genetic factors. The remaining variance is attributable to the non-shared environment, which, by definition, includes combat exposure. This study used a gene by measured environment twin design to determine whether the effects of genetic and environmental factors that contribute to the etiology of PTSD are dependent on the level of combat exposure. The sample was drawn from the Vietnam Era Twin Registry (VETR) and included 620 male-male twin pairs who served in the US Military in South East Asia during the Vietnam War era. Analyses were based on data from a clinical diagnostic interview of lifetime PTSD symptoms and a self-report measure of combat exposure. Biometric modeling revealed that the effects of genetic and non-shared environment factors on PTSD varied as a function of level of combat exposure such that the association between these factors and PTSD was stronger at higher levels of combat exposure. Combat exposure may act as a catalyst that augments the impact of hereditary and environmental contributions to PTSD. Individuals with the greatest exposure to combat trauma were at increased risk for PTSD as a function of both genetic and environmental factors. Additional work is needed to determine the biological and environmental mechanisms driving these associations. JF - Psychological Medicine AU - Wolf, E J AU - Mitchell, K S AU - Koenen, K C AU - Miller, M W AD - National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA, Erika.Wolf@va.gov Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 1499 EP - 1509 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 44 IS - 7 SN - 0033-2917, 0033-2917 KW - Genetics Abstracts; Risk Abstracts; CSA Neurosciences Abstracts KW - Genetic factors KW - Psychology KW - Environmental factors KW - Vietnam KW - War KW - Risk factors KW - Catalysts KW - Asia KW - Military KW - Etiology KW - Data processing KW - Biometrics KW - Liability KW - Post-traumatic stress disorder KW - Trauma KW - Posttraumatic stress disorder KW - Twins KW - Military personnel KW - N3 11001:Behavioral and Cognitive Neuroscience KW - G 07750:Ecological & Population Genetics KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1516740617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Combat+exposure+severity+as+a+moderator+of+genetic+and+environmental+liability+to+post-traumatic+stress+disorder&rft.au=Wolf%2C+E+J%3BMitchell%2C+K+S%3BKoenen%2C+K+C%3BMiller%2C+M+W&rft.aulast=Wolf&rft.aufirst=E&rft.date=2014-05-01&rft.volume=44&rft.issue=7&rft.spage=1499&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291713002286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Number of references - 54 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Etiology; Genetic factors; Data processing; Twins; War; Catalysts; Biometrics; Environmental factors; Post-traumatic stress disorder; Military personnel; Trauma; Posttraumatic stress disorder; Psychology; Risk factors; Liability; Military; Asia; Vietnam DO - http://dx.doi.org/10.1017/S0033291713002286 ER - TY - JOUR T1 - A Position Article for Applying Spirituality to Suicide Prevention AN - 1541982167; 201419270 AB - Suicide is a major public health concern in the United States. Halting the rising trend of suicides requires that new options be identified and implemented so as to achieve the overarching goal of reducing the total number of suicide deaths and attempts in America. The aim of this article is to review constructs and outline a proposed operational framework for incorporating spiritual well-being into suicide prevention efforts. By presenting conceptual, preventive, and theoretical arguments, the hope is to elicit empirical interest in finding practical applications for the protective potential of spirituality. Adapted from the source document. JF - Journal of Spirituality in Mental Health AU - Kopacz, Marek S AU - Silver, Eric AU - Bossarte, Robert M AD - U.S. Department of Veterans Affairs, VISN 2 Center of Excellence for Suicide Prevention, Canandaigua, NY, USA Y1 - 2014/04/03/ PY - 2014 DA - 2014 Apr 03 SP - 133 EP - 146 PB - Taylor & Francis, Philadelphia PA VL - 16 IS - 2 SN - 1934-9637, 1934-9637 KW - Goals KW - Spirituality KW - Hope KW - Suicide KW - Preventive programmes KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541982167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Spirituality+in+Mental+Health&rft.atitle=A+Position+Article+for+Applying+Spirituality+to+Suicide+Prevention&rft.au=Kopacz%2C+Marek+S%3BSilver%2C+Eric%3BBossarte%2C+Robert+M&rft.aulast=Kopacz&rft.aufirst=Marek&rft.date=2014-04-03&rft.volume=16&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Journal+of+Spirituality+in+Mental+Health&rft.issn=19349637&rft_id=info:doi/10.1080%2F19349637.2014.896856 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Suicide; Preventive programmes; Spirituality; Hope; Goals; Public health DO - http://dx.doi.org/10.1080/19349637.2014.896856 ER - TY - JOUR T1 - Rates and Predictors of Referral for Individual Psychotherapy, Group Psychotherapy, and Medications among Iraq and Afghanistan Veterans with PTSD AN - 1558995902; 201430837 AB - This study examined rates of referral for medication, individual psychotherapy, and group psychotherapy within a Veterans Affairs (VA) posttraumatic stress disorder (PTSD) specialty mental health clinic. Participants were 388 Iraq and Afghanistan veterans who were referred for PTSD treatment following a mental health evaluation required for all new VA enrollees. The majority of the sample was referred for medication (79 %), with comparatively fewer referrals for individual (39 %) or group psychotherapy (24 %). Forty percent of participants were referred for combined medication and psychotherapy. Patient demographic and clinical characteristics were examined to determine whether these variables predicted referral type. Female veterans and those with lower clinician ratings of overall functioning were more likely to be referred for individual therapy. Group psychotherapy referrals were more common in veterans who were older, unemployed, identified as an ethnic minority, and had a comorbid anxiety disorder. There were no significant predictors of medication referral. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Mott, Juliette M AU - Barrera, Terri L AU - Hernandez, Caitlin AU - Graham, David P AU - Teng, Ellen J AD - VA HSR&D Houston Center of Excellence, Houston, TX, USA juliette.mott@va.gov Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 99 EP - 109 PB - Springer, US VL - 41 IS - 2 SN - 1094-3412, 1094-3412 KW - Veterans KW - Mental health services KW - Posttraumatic stress disorder KW - Referrals KW - Group psychotherapy KW - Iraq KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558995902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Rates+and+Predictors+of+Referral+for+Individual+Psychotherapy%2C+Group+Psychotherapy%2C+and+Medications+among+Iraq+and+Afghanistan+Veterans+with+PTSD&rft.au=Mott%2C+Juliette+M%3BBarrera%2C+Terri+L%3BHernandez%2C+Caitlin%3BGraham%2C+David+P%3BTeng%2C+Ellen+J&rft.aulast=Mott&rft.aufirst=Juliette&rft.date=2014-04-01&rft.volume=41&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-013-9352-0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Number of references - 37 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Referrals; Veterans; Posttraumatic stress disorder; Group psychotherapy; Iraq; Mental health services DO - http://dx.doi.org/10.1007/s11414-013-9352-0 ER - TY - JOUR T1 - Insomnia and Hypnotic Medications are Associated with Suicidal Ideation in a Community Population AN - 1541977897; 201421595 AB - Suicidal ideation (SI), a significant predictor of suicide, is associated with sleep disturbance, which is seldom assessed using stringent diagnostic criteria and validated sleep instruments in community samples. Cross-sectional data, including sleep diaries and validated instruments, from 767 community adults were used to identify variables associated with SI and subsequently entered into a regression model to predict SI. Suicidal ideation was endorsed by 9.3% of the sample. This group differed from non-ideators on several variables, but only insomnia diagnosis, depression severity, and hypnotic medication use predicted SI. Findings confirm an association of insomnia with SI using stringent criteria and controlling for depression. If treating insomnia is a conceivable pathway to reduce SI, the apparent risk posed by hypnotics may limit treatment options. JF - Archives of Suicide Research AU - Pigeon, Wilfred R AU - Woosley, Julie A AU - Lichstein, Kenneth L AD - Center of Excellence for Suicide Prevention, VA Medical Center, Canandaigua, New York, USA Wilfred.pigeon2@va.gov Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 170 EP - 180 PB - Taylor & Francis, Philadelphia PA VL - 18 IS - 2 SN - 1381-1118, 1381-1118 KW - Insomnia KW - Depression KW - Sleep KW - Suicidal ideation KW - Suicide KW - Risk reduction KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541977897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Suicide+Research&rft.atitle=Insomnia+and+Hypnotic+Medications+are+Associated+with+Suicidal+Ideation+in+a+Community+Population&rft.au=Pigeon%2C+Wilfred+R%3BWoosley%2C+Julie+A%3BLichstein%2C+Kenneth+L&rft.aulast=Pigeon&rft.aufirst=Wilfred&rft.date=2014-04-01&rft.volume=18&rft.issue=2&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Archives+of+Suicide+Research&rft.issn=13811118&rft_id=info:doi/10.1080%2F13811118.2013.824837 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - ASREFQ N1 - SubjectsTermNotLitGenreText - Insomnia; Suicidal ideation; Sleep; Depression; Risk reduction; Suicide DO - http://dx.doi.org/10.1080/13811118.2013.824837 ER - TY - JOUR T1 - Increasing Colorectal Cancer Screening in an Overdue Population: Participation and Cost Impacts of Adding Telephone Calls to a FIT Mailing Program AN - 1540223866; 19363303 AB - Many people who live in rural areas face distance barriers to colonoscopy. Our previous study demonstrated the utility of mailing fecal immunochemical tests (FIT) to average risk patients overdue for colorectal cancer (CRC screening). The aims of this study were to determine if introductory and reminder telephone calls would increase the proportion of returned FITs as well as to compare costs. Average risk patients overdue for CRC screening received a high intensity intervention (HII), which included an introductory telephone call to see if they were interested in taking a FIT prior to mailing the test out and reminder phone calls if the FIT was not returned. This HII group was compared to our previous low intensity intervention (LII) where a FIT was mailed to a similar group of veterans with no telephone contact. While a higher proportion of eligible respondents returned FITs in the LII (92 vs. 45 %), there was a much higher proportion of FITs returned out of those mailed in the HII (85 vs. 14 %). The fewer wasted FITs in the HII led to it having lower cost per FIT returned ($27.43 vs. $44.86). Given that either intervention is a feasible approach for patients overdue for CRC screening, health care providers should consider offering FITs using a home-based mailing program along with other evidence-based CRC screening options to average risk patients. Factors such as location, patient population, FIT cost and reimbursement, and personnel costs need to be considered when deciding the most effective way to implement FIT screening. JF - Journal of Community Health AU - Schlichting, Jennifer A AU - Mengeling, Michelle A AU - Makki, Nader M AU - Malhotra, Ashish AU - Halfdanarson, Thorvardur R AU - Klutts, JStacey AU - Levy, Barcey T AU - Kaboli, Peter J AU - Charlton, Mary E AD - VA Office of Rural Health, Rural Health Resource Center - Central Region, Iowa City VA Healthcare System, 601 Hwy 6 West, Iowa City, IA, 52246, USA, mary.charlton@va.gov Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 239 EP - 247 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 39 IS - 2 SN - 0094-5145, 0094-5145 KW - Risk Abstracts KW - Fecal coliforms KW - Health care KW - Risk factors KW - Intervention KW - Colorectal carcinoma KW - Rural areas KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1540223866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Increasing+Colorectal+Cancer+Screening+in+an+Overdue+Population%3A+Participation+and+Cost+Impacts+of+Adding+Telephone+Calls+to+a+FIT+Mailing+Program&rft.au=Schlichting%2C+Jennifer+A%3BMengeling%2C+Michelle+A%3BMakki%2C+Nader+M%3BMalhotra%2C+Ashish%3BHalfdanarson%2C+Thorvardur+R%3BKlutts%2C+JStacey%3BLevy%2C+Barcey+T%3BKaboli%2C+Peter+J%3BCharlton%2C+Mary+E&rft.aulast=Schlichting&rft.aufirst=Jennifer&rft.date=2014-04-01&rft.volume=39&rft.issue=2&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-014-9830-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Number of references - 24 N1 - Last updated - 2014-06-26 N1 - SubjectsTermNotLitGenreText - Fecal coliforms; Health care; Risk factors; Colorectal carcinoma; Intervention; Rural areas DO - http://dx.doi.org/10.1007/s10900-014-9830-1 ER - TY - JOUR T1 - New beta -Lactamase Inhibitors: a Therapeutic Renaissance in an MDR World AN - 1520386024; 19634081 AB - As the incidence of Gram-negative bacterial infections for which few effective treatments remain increases, so does the contribution of drug-hydrolyzing beta -lactamase enzymes to this serious clinical problem. This review highlights recent advances in beta -lactamase inhibitors and focuses on agents with novel mechanisms of action against a wide range of enzymes. To this end, we review the beta -lactamase inhibitors currently in clinical trials, select agents still in preclinical development, and older therapeutic approaches that are being revisited. Particular emphasis is placed on the activity of compounds at the forefront of the developmental pipeline, including the diazabicyclooctane inhibitors (avibactam and MK-7655) and the boronate RPX7009. With its novel reversible mechanism, avibactam stands to be the first new beta -lactamase inhibitor brought into clinical use in the past 2 decades. Our discussion includes the importance of selecting the appropriate partner beta -lactam and dosing regimens for these promising agents. This "renaissance" of beta -lactamase inhibitors offers new hope in a world plagued by multidrug-resistant (MDR) Gram-negative bacteria. JF - Antimicrobial Agents & Chemotherapy AU - Drawz, Sarah M AU - Papp-Wallace, Krisztina M AU - Bonomo, Robert A AD - Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA, robert.bonomo@va.gov. Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 1835 EP - 1846 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 58 IS - 4 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - beta -Lactamase KW - Gram-negative bacteria KW - Reviews KW - Drug resistance KW - beta -Lactam antibiotics KW - Enzymes KW - Development KW - Infection KW - Clinical trials KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520386024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=New+beta+-Lactamase+Inhibitors%3A+a+Therapeutic+Renaissance+in+an+MDR+World&rft.au=Drawz%2C+Sarah+M%3BPapp-Wallace%2C+Krisztina+M%3BBonomo%2C+Robert+A&rft.aulast=Drawz&rft.aufirst=Sarah&rft.date=2014-04-01&rft.volume=58&rft.issue=4&rft.spage=1835&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00826-13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Number of references - 124 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - beta -Lactamase; Drug resistance; Reviews; Gram-negative bacteria; beta -Lactam antibiotics; Enzymes; Development; Infection; Clinical trials DO - http://dx.doi.org/10.1128/AAC.00826-13 ER - TY - JOUR T1 - All-Cause Mortality and Liver-Related Outcomes Following Successful Antiviral Treatment for Chronic Hepatitis C AN - 1520377651; 19445528 AB - Background: Antiviral therapy for the hepatitis C virus (HCV) reduces all-cause and liver-related morbidity and mortality. Few studies are available from populations with multiple medical and psychiatric comorbidities where the impact of successful antiviral therapy might be limited. Aim: The purpose of this study was to determine the effect of sustained virologic response (SVR) on all-cause and liver-related mortality in a cohort of HCV patients treated in an integrated hepatitis/mental health clinic. Methods: This was a retrospective review of all patients who initiated antiviral treatment for chronic HCV between January 1, 1997 and December 31, 2009. Cox regression analysis was used to determine factors involved in all-cause mortality, liver-related events and hepatocellular carcinoma. Results: A total of 536 patients were included in the analysis. Median follow-up was 7.5 years. Liver and non-liver-related mortality occurred in 2.7 and 5.0 % of patients with SVR and in 17.8 and 6.4 % of patients without SVR. In a multivariate analysis, SVR was the only factor associated with reduced all-cause mortality (HR 0.47; 95 % CI 0.26-0.85; p = 0.012) and reduced liver-related events (HR 0.23; 95 % CI 0.08-0.66, p = 0.007). Having stage 4 liver fibrosis increased all-cause mortality (HR 2.50; 95 % CI 1.23-5.08; p = 0.011). Thrombocytopenia at baseline (HR 2.66; 95 % CI 1.22-5.79; p = 0.014) and stage 4 liver fibrosis (HR 4.87; 95 % CI 1.62-14.53; p = 0.005) increased liver-related events. Conclusions: Despite significant medical and psychiatric comorbidities, SVR markedly reduced liver-related outcomes without a significant change in non-liver-related mortality after a median follow-up of 7.5 years. JF - Digestive Diseases and Sciences AU - Dieperink, Eric AU - Pocha, Christine AU - Thuras, Paul AU - Knott, Astrid AU - Colton, Samuel AU - Ho, Samuel B AD - Department of Psychiatry (116A), Minneapolis Veterans Affairs Health Care System, One Veterans Drive, Minneapolis, MN, 55417, USA, Eric.dieperink@va.gov Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 872 EP - 880 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 59 IS - 4 SN - 0163-2116, 0163-2116 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Mortality KW - Mental disorders KW - Thrombocytopenia KW - Hepatitis C virus KW - Fibrosis KW - Multivariate analysis KW - Regression analysis KW - Hepatitis C KW - Morbidity KW - Hepatocellular carcinoma KW - A 01340:Antibiotics & Antimicrobials KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520377651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+Diseases+and+Sciences&rft.atitle=All-Cause+Mortality+and+Liver-Related+Outcomes+Following+Successful+Antiviral+Treatment+for+Chronic+Hepatitis+C&rft.au=Dieperink%2C+Eric%3BPocha%2C+Christine%3BThuras%2C+Paul%3BKnott%2C+Astrid%3BColton%2C+Samuel%3BHo%2C+Samuel+B&rft.aulast=Dieperink&rft.aufirst=Eric&rft.date=2014-04-01&rft.volume=59&rft.issue=4&rft.spage=872&rft.isbn=&rft.btitle=&rft.title=Digestive+Diseases+and+Sciences&rft.issn=01632116&rft_id=info:doi/10.1007%2Fs10620-014-3050-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Number of references - 31 N1 - Last updated - 2015-11-25 N1 - SubjectsTermNotLitGenreText - Mortality; Mental disorders; Thrombocytopenia; Multivariate analysis; Fibrosis; Regression analysis; Hepatitis C; Morbidity; Hepatocellular carcinoma; Hepatitis C virus DO - http://dx.doi.org/10.1007/s10620-014-3050-5 ER - TY - JOUR T1 - Current approaches to the treatment of metastatic brain tumours. AN - 1511394298; 24569448 AB - Metastatic tumours involving the brain overshadow primary brain neoplasms in frequency and are an important complication in the overall management of many cancers. Importantly, advances are being made in understanding the molecular biology underlying the initial development and eventual proliferation of brain metastases. Surgery and radiation remain the cornerstones of the therapy for symptomatic lesions; however, image-based guidance is improving surgical technique to maximize the preservation of normal tissue, while more sophisticated approaches to radiation therapy are being used to minimize the long-standing concerns over the toxicity of whole-brain radiation protocols used in the past. Furthermore, the burgeoning knowledge of tumour biology has facilitated the entry of systemically administered therapies into the clinic. Responses to these targeted interventions have ranged from substantial toxicity with no control of disease to periods of useful tumour control with no decrement in performance status of the treated individual. This experience enables recognition of the limits of targeted therapy, but has also informed methods to optimize this approach. This Review focuses on the clinically relevant molecular biology of brain metastases, and summarizes the current applications of these data to imaging, surgery, radiation therapy, cytotoxic chemotherapy and targeted therapy. JF - Nature reviews. Clinical oncology AU - Owonikoko, Taofeek K AU - Arbiser, Jack AU - Zelnak, Amelia AU - Shu, Hui-Kuo G AU - Shim, Hyunsuk AU - Robin, Adam M AU - Kalkanis, Steven N AU - Whitsett, Timothy G AU - Salhia, Bodour AU - Tran, Nhan L AU - Ryken, Timothy AU - Moore, Michael K AU - Egan, Kathleen M AU - Olson, Jeffrey J AD - Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA. ; Department of Dermatology, Atlanta Veterans Administration Medical Center, Emory University, Atlanta, GA 30322, USA. ; Department of Radiation Oncology, Emory University, Atlanta, GA 30322, USA. ; Department of Neurosurgery, Henry Ford Health System, 2799 West Grand Boulevard, K-11, Detroit, MI 48202, USA. ; Division of Cancer and Cell Biology, Translational Genomics Research Institute, 445 North 5th Street, Phoenix, AZ 85004, USA. ; Division of Integrated Cancer Genomics, Translational Genomics Research Institute, 445 North 5th Street, Phoenix, AZ 85004, USA. ; Iowa Spine and Brain Institute, 2710 St Francis Drive, Suite 110, Waterloo, IA 50702, USA. ; Department of Neurosurgery, Emory University, Atlanta, GA 30322, USA. ; H. Lee Moffitt Cancer Center & Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA. Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 203 EP - 222 VL - 11 IS - 4 KW - Antineoplastic Agents KW - 0 KW - Neoplasm Proteins KW - Index Medicus KW - Heterografts KW - Animals KW - Neuroimaging KW - Neoplasm Proteins -- antagonists & inhibitors KW - Surgery, Computer-Assisted KW - Combined Modality Therapy KW - Radiation Injuries -- prevention & control KW - Neoplastic Stem Cells -- pathology KW - Antineoplastic Agents -- pharmacokinetics KW - Humans KW - Molecular Targeted Therapy KW - Mice KW - Cranial Irradiation -- methods KW - Neurosurgical Procedures KW - Gene Expression Profiling KW - Cranial Irradiation -- adverse effects KW - Radiography, Interventional KW - Antineoplastic Agents -- therapeutic use KW - Brain Damage, Chronic -- etiology KW - Brain Damage, Chronic -- prevention & control KW - Radiation Injuries -- etiology KW - Carcinoma -- therapy KW - Carcinoma -- secondary KW - Brain Neoplasms -- therapy KW - Carcinoma -- blood supply KW - Brain Neoplasms -- blood supply KW - Brain Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1511394298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Clinical+oncology&rft.atitle=Current+approaches+to+the+treatment+of+metastatic+brain+tumours.&rft.au=Owonikoko%2C+Taofeek+K%3BArbiser%2C+Jack%3BZelnak%2C+Amelia%3BShu%2C+Hui-Kuo+G%3BShim%2C+Hyunsuk%3BRobin%2C+Adam+M%3BKalkanis%2C+Steven+N%3BWhitsett%2C+Timothy+G%3BSalhia%2C+Bodour%3BTran%2C+Nhan+L%3BRyken%2C+Timothy%3BMoore%2C+Michael+K%3BEgan%2C+Kathleen+M%3BOlson%2C+Jeffrey+J&rft.aulast=Owonikoko&rft.aufirst=Taofeek&rft.date=2014-04-01&rft.volume=11&rft.issue=4&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Clinical+oncology&rft.issn=1759-4782&rft_id=info:doi/10.1038%2Fnrclinonc.2014.25 LA - English DB - ProQuest 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[20406990] Int J Mol Sci. 2013;14(8):17157-67 [23965978] BMJ Case Rep. 2013;2013. pii: bcr-2013-200867. doi: 10.1136/bcr-2013-200867 [24022905] PLoS One. 2013;8(9):e73406 [24039934] Cancer Res. 2013 Sep 15;73(18):5764-74 [23913825] Cancer. 2011 Jun 1;117(11):2505-12 [24048799] Neuro Oncol. 2013 Oct;15(10):1429-37 [23956241] J Neurooncol. 2013 Oct;115(1):61-70 [23817810] J Natl Cancer Inst. 2013 Nov 6;105(21):1634-43 [24108809] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/nrclinonc.2014.25 ER - TY - JOUR T1 - Association between arsenic exposure from drinking water and hematuria: results from the Health Effects of Arsenic Longitudinal Study. AN - 1508428901; 24486435 AB - Arsenic (As) exposure has been associated with both urologic malignancy and renal dysfunction; however, its association with hematuria is unknown. We evaluated the association between drinking water As exposure and hematuria in 7843 men enrolled in the Health Effects of Arsenic Longitudinal Study (HEALS). Cross-sectional analysis of baseline data was conducted with As exposure assessed in both well water and urinary As measurements, while hematuria was measured using urine dipstick. Prospective analyses with Cox proportional regression models were based on urinary As and dipstick measurements obtained biannually since baseline up to six years. At baseline, urinary As was significantly related to prevalence of hematuria (P-trend47.49 μg/l and 10.87 to 47.49 μg/l since last visit, respectively, and 1.17 (95% CI: 0.94-1.45) and 1.36 (95% CI: 1.10-1.66) for those with between-visit increases of 10.40 to 41.17 μg/l and >41.17 μg/l, respectively. These data indicate a positive association of As exposure with both prevalence and incidence of dipstick hematuria. This exposure effect appears modifiable by relatively short-term changes in drinking water As. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - McClintock, Tyler R AU - Chen, Yu AU - Parvez, Faruque AU - Makarov, Danil V AU - Ge, Wenzhen AU - Islam, Tariqul AU - Ahmed, Alauddin AU - Rakibuz-Zaman, Muhammad AU - Hasan, Rabiul AU - Sarwar, Golam AU - Slavkovich, Vesna AU - Bjurlin, Marc A AU - Graziano, Joseph H AU - Ahsan, Habibul AD - Department of Population Health, New York University School of Medicine, New York, NY, USA; Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA; Department of Urology, New York University School of Medicine, New York, NY, USA. ; Department of Population Health, New York University School of Medicine, New York, NY, USA; Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA. Electronic address: yu.chen@nyumc.org. ; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA. ; Department of Urology, New York University School of Medicine, New York, NY, USA; Robert F. Wagner Graduate School of Public Service, New York University, New York, NY, USA; United States Department of Veterans Affairs Harbor Healthcare System, New York, NY, USA; New York University Cancer Institute, New York, NY, USA. ; Department of Population Health, New York University School of Medicine, New York, NY, USA; Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA. ; U-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh. ; Department of Urology, New York University School of Medicine, New York, NY, USA. ; Department of Health Studies, The University of Chicago, Chicago, IL, USA; Department of Medicine, The University of Chicago, Chicago, IL, USA; Department of Human Genetics, The University of Chicago, Chicago, IL, USA; Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA. Electronic address: habib@uchicago.edu. Y1 - 2014/04/01/ PY - 2014 DA - 2014 Apr 01 SP - 21 EP - 27 VL - 276 IS - 1 KW - Drinking Water KW - 0 KW - Reagent Strips KW - Water Pollutants, Chemical KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Environmental epidemiology KW - Urologic neoplasms KW - Hematuria KW - Mass screening KW - Bangladesh KW - Administration, Oral KW - Humans KW - Longitudinal Studies KW - Cross-Sectional Studies KW - Mass Screening KW - Prospective Studies KW - Water Wells -- chemistry KW - Adult KW - Cohort Studies KW - Incidence KW - Bangladesh -- epidemiology KW - Male KW - Prevalence KW - Proportional Hazards Models KW - Arsenic -- analysis KW - Rural Health KW - Arsenic -- toxicity KW - Arsenic Poisoning -- etiology KW - Water Pollutants, Chemical -- analysis KW - Water Pollutants, Chemical -- toxicity KW - Water Pollutants, Chemical -- administration & dosage KW - Arsenic Poisoning -- physiopathology KW - Drinking Water -- chemistry KW - Water Quality KW - Arsenic -- administration & dosage KW - Arsenic Poisoning -- epidemiology KW - Arsenic -- urine KW - Hematuria -- etiology KW - Water Pollutants, Chemical -- urine KW - Arsenic Poisoning -- urine KW - Drinking Water -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1508428901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Association+between+arsenic+exposure+from+drinking+water+and+hematuria%3A+results+from+the+Health+Effects+of+Arsenic+Longitudinal+Study.&rft.au=McClintock%2C+Tyler+R%3BChen%2C+Yu%3BParvez%2C+Faruque%3BMakarov%2C+Danil+V%3BGe%2C+Wenzhen%3BIslam%2C+Tariqul%3BAhmed%2C+Alauddin%3BRakibuz-Zaman%2C+Muhammad%3BHasan%2C+Rabiul%3BSarwar%2C+Golam%3BSlavkovich%2C+Vesna%3BBjurlin%2C+Marc+A%3BGraziano%2C+Joseph+H%3BAhsan%2C+Habibul&rft.aulast=McClintock&rft.aufirst=Tyler&rft.date=2014-04-01&rft.volume=276&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2014.01.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-05-16 N1 - Date created - 2014-03-17 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Mayo Clin Proc. 2013 Feb;88(2):129-38 [23312369] World J Urol. 2012 Dec;30(6):847-52 [23124847] Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):623-30 [23355602] Am J Epidemiol. 2013 Sep 1;178(5):813-8 [23764934] Lancet. 1988 Feb 20;1(8582):414-5 [2893213] Clin Chem. 1991 Sep;37(9):1575-9 [1893592] Am J Epidemiol. 1995 Mar 15;141(6):523-30 [7900719] Urology. 2001 Apr;57(4):599-603 [11306356] N Engl J Med. 2003 Jun 5;348(23):2330-8 [12788998] Scand J Clin Lab Invest. 1965;17(4):381-7 [5838275] Cancer Res. 1985 Nov;45(11 Pt 2):5895-9 [4053060] Br J Cancer. 1986 Mar;53(3):399-405 [3964542] Int J Epidemiol. 1998 Aug;27(4):561-9 [9758107] Environ Health Perspect. 1999 May;107(5):359-65 [10210691] Environ Health Perspect. 1999 Sep;107(9):705-10 [10464069] IARC Monogr Eval Carcinog Risks Hum. 2004;84:1-477 [15645577] J Toxicol Environ Health A. 2005 Mar 12;68(5):319-27 [15799625] Environ Sci Technol. 2005 Jul 1;39(13):4759-66 [16053073] Arch Intern Med. 2005 Oct 24;165(19):2299-304 [16246998] J Expo Sci Environ Epidemiol. 2006 Mar;16(2):191-205 [16160703] Am J Epidemiol. 2006 Jun 15;163(12):1138-48 [16624965] Environ Health. 2007;6:4 [17274811] J Natl Cancer Inst. 2007 Jun 20;99(12):920-8 [17565158] Environ Health Perspect. 2007 Jun;115(6):917-23 [17589600] Environ Res. 2008 Feb;106(2):212-8 [17900556] Am J Kidney Dis. 2009 Nov;54(5):859-70 [19682779] Epidemiology. 2010 Jan;21(1):103-8 [20010213] Toxicol Lett. 2010 Mar 15;193(2):131-7 [20051252] J Urol. 2011 May;185(5):1698-703 [21419446] BMJ. 2011;342:d2431 [21546419] J Urol. 2011 Jun;185(6):2040-4 [21496841] Int J Epidemiol. 2011 Jun;40(3):828-35 [21343184] Sci Total Environ. 2012 Jul 1;429:76-91 [22119448] J Urol. 2012 Dec;188(6 Suppl):2473-81 [23098784] Environ Health Perspect. 2013 Mar;121(3):295-302 [23458756] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2014.01.015 ER - TY - JOUR T1 - Outcomes and tolerance of human immunodeficiency virus--positive U.S. veterans undergoing dose-escalated external beam radiotherapy for localized prostate cancer. AN - 1508413291; 24176940 AB - There are little data on the outcomes and tolerance, as well as the impact on the CD4 counts, of human immunodeficiency virus (HIV)-positive patients with prostate cancer who undergo high-dose external beam radiotherapy. We identified 15 HIV-positive patients with prostate cancer who were treated with external beam radiation to a dose ≥ 75.6 Gy at the New York Harbor Department of Veterans Affairs between 2003 and 2010. Kaplan-Meier analyses were used to measure biochemical control outcomes. Toxicity and CD4 counts before, after, and during treatments were analyzed. A total of 15 patients were identified, with a median follow-up period of 49 months. There were 2 biochemical failures, which occurred at 28 months and 63 months, respectively. In neither of these 2 patients was there evidence of metastatic disease. The overall 5-year biochemical control was 92.3%. There appeared to be a consistent decline in the CD4 counts both during and immediately after the radiation treatments. Most of these patients had a subsequent improvement in their CD4 counts. Toxicity was mild overall, though there was 1 patient who developed rectal bleeding 11 months post treatment, which required argon plasma coagulation. Dose-escalated external beam radiation is well tolerated in HIV-positive patients with durable biochemical control and mild toxicity. A substantial decline in CD4 counts is associated with the radiation; therefore, these counts need to be monitored closely, in conjunction with the infectious-disease specialist. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Clinical genitourinary cancer AU - Schreiber, David AU - Chhabra, Arpit AU - Rineer, Justin AU - Nabhani, Thomas AU - Katsoulakis, Evangelia AU - Morkos, Ramez AU - Rotman, Marvin AU - Schwartz, David AD - Department of Veterans Affairs, New York Harbor Healthcare System, Brooklyn, NY; Department of Radiation Oncology, SUNY Downstate Medical Center, Brooklyn, NY. Electronic address: David.schreiber@va.gov. ; Department of Veterans Affairs, New York Harbor Healthcare System, Brooklyn, NY. ; MD Anderson Cancer Center Orlando, Orlando, FL. ; Cochise Oncology, Sierra Vista, AZ. ; New York Methodist Hospital, Brooklyn, NY. ; Department of Veterans Affairs, New York Harbor Healthcare System, Brooklyn, NY; Department of Radiation Oncology, SUNY Downstate Medical Center, Brooklyn, NY. Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 94 EP - 99 VL - 12 IS - 2 KW - Index Medicus KW - Prostate cancer KW - Human immunodeficiency virus KW - External beam radiotherapy KW - Toxicity KW - CD4 count KW - Kaplan-Meier Estimate KW - Disease-Free Survival KW - Dose Fractionation KW - Humans KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Prostatic Neoplasms -- mortality KW - Prostatic Neoplasms -- immunology KW - HIV Infections -- immunology KW - Prostatic Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1508413291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+genitourinary+cancer&rft.atitle=Outcomes+and+tolerance+of+human+immunodeficiency+virus--positive+U.S.+veterans+undergoing+dose-escalated+external+beam+radiotherapy+for+localized+prostate+cancer.&rft.au=Schreiber%2C+David%3BChhabra%2C+Arpit%3BRineer%2C+Justin%3BNabhani%2C+Thomas%3BKatsoulakis%2C+Evangelia%3BMorkos%2C+Ramez%3BRotman%2C+Marvin%3BSchwartz%2C+David&rft.aulast=Schreiber&rft.aufirst=David&rft.date=2014-04-01&rft.volume=12&rft.issue=2&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Clinical+genitourinary+cancer&rft.issn=1938-0682&rft_id=info:doi/10.1016%2Fj.clgc.2013.07.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-05 N1 - Date created - 2014-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.clgc.2013.07.008 ER - TY - JOUR T1 - HealthViEWS: Mortality Study of Female US Vietnam Era Veterans, 1965-2010 AN - 1512334952; 19377175 AB - We conducted a retrospective study among 4,734 women who served in the US military in Vietnam (Vietnam cohort), 2,062 women who served in countries near Vietnam (near-Vietnam cohort), and 5,313 nondeployed US military women (US cohort) to evaluate the associations of mortality outcomes with Vietnam War service. Veterans were identified from military records and followed for 40 years through December 31, 2010. Information on underlying causes of death was obtained from death certificates and the National Death Index. Based on 2,743 deaths, all 3 veteran cohorts had lower mortality risk from all causes combined and from several major causes, such as diabetes mellitus, heart disease, chronic obstructive pulmonary disease, and nervous system disease relative to comparable US women. However, excess deaths from motor vehicle accidents were observed in the Vietnam cohort (standardized mortality ratio = 3.67, 95% confidence interval (CI): 2.30, 5.56) and in the US cohort (standardized mortality ratio = 1.91, 95% CI: 1.02, 3.27). More than two-thirds of women in the study were military nurses. Nurses in the Vietnam cohort had a 2-fold higher risk of pancreatic cancer death (adjusted relative risk = 2.07, 95% CI: 1.00, 4.25) and an almost 5-fold higher risk of brain cancer death compared with nurses in the US cohort (adjusted relative risk = 4.61, 95% CI: 1.27, 16.83). Findings of all-cause and motor vehicle accident deaths among female Vietnam veterans were consistent with patterns of postwar mortality risk among other war veterans. JF - American Journal of Epidemiology AU - Kang, Han K AU - Cypel, Yasmin AU - Kilbourne, Amy M AU - Magruder, Kathy M AU - Serpi, Tracey AU - Collins, Joseph F AU - Frayne, Susan M AU - Furey, Joan AU - Huang, Grant D AU - Kimerling, Rachel AU - Reinhard, Matthew J AU - Schumacher, Karen AU - Spiro, Avron AD - Correspondence to Dr. Yasmin Cypel, Epidemiology Program, Post-Deployment Health Strategic Healthcare Group (10P3A), Office of Public Health, Department of Veterans Affairs, Washington, DC 20420., yasmin.cypel@va.gov Y1 - 2014/03/15/ PY - 2014 DA - 2014 Mar 15 SP - 721 EP - 730 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 179 IS - 6 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Motor vehicles KW - Brain KW - Pancreatic cancer KW - Cancer KW - Medical personnel KW - Vietnam KW - Health risks KW - USA KW - Accidents KW - War KW - Nursing KW - Standards KW - Females KW - Military KW - Heart diseases KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1512334952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=HealthViEWS%3A+Mortality+Study+of+Female+US+Vietnam+Era+Veterans%2C+1965-2010&rft.au=Kang%2C+Han+K%3BCypel%2C+Yasmin%3BKilbourne%2C+Amy+M%3BMagruder%2C+Kathy+M%3BSerpi%2C+Tracey%3BCollins%2C+Joseph+F%3BFrayne%2C+Susan+M%3BFurey%2C+Joan%3BHuang%2C+Grant+D%3BKimerling%2C+Rachel%3BReinhard%2C+Matthew+J%3BSchumacher%2C+Karen%3BSpiro%2C+Avron&rft.aulast=Kang&rft.aufirst=Han&rft.date=2014-03-15&rft.volume=179&rft.issue=6&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwt319 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Mortality; Motor vehicles; Pancreatic cancer; Brain; Medical personnel; Cancer; Health risks; Accidents; War; Nursing; Standards; Females; Military; Heart diseases; USA; Vietnam DO - http://dx.doi.org/10.1093/aje/kwt319 ER - TY - JOUR T1 - Does Brain Reserve Protect Older Women from Vascular Depression? AN - 1665163983 AB - Objectives. Brain reserve theory, typically discussed in relation to dementia, was examined with regard to late-life depression symptomatology and cerebrovascular burden (CVB) in older-old women. Method. It was predicted that in a 6-year longitudinal sample (Health and Retirement Study) of 1,355 stroke-free women aged 80 years and older, higher levels of depressive symptomatology (8-item Center for Epidemiologic Studies-Depression score) would be predicted by high CVB, less educational attainment, and the education x CVB interaction after controlling for age and cognitive functioning (Telephone Interview for Cognitive Status). A latent growth curve model was used to identify differences in depression symptomatology at baseline and over time. Logistic regression analyses were used to predict clinically significant depressive symptomatology at each wave based on CVB, education, and the education x CVB interaction. Results. Results indicate that among older women, greater educational attainment predicted fewer depression symptoms at baseline, but this advantage was partially eroded over time. The education x CVB interaction predicted clinically significant depressive symptoms at baseline when the benefits of education were most robust. Discussion. Brain reserve, characterized by educational attainment, may counterbalance the effect of high CVB with respect to depressive symptoms, thereby preserving mood in late life. These findings support the application of brain reserve theory to late-life depression. JF - The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences AU - Paulson, Daniel AU - Bowen, Mary Elizabeth AU - Lichtenberg, Peter A AD - Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, Michigan; Department of Mental Health, Ralph H. Johnson VA Medical Center, Charleston, South Carolina ; HSR&D/RR&D Center of Excellence, Veterans Health Administration, Tampa, Florida ; Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, Michigan ; Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, Michigan; Department of Mental Health, Ralph H. Johnson VA Medical Center, Charleston, South Carolina Y1 - 2014/03// PY - 2014 DA - Mar 2014 SP - 157 EP - 167 CY - Washington PB - Oxford University Press, UK VL - 69 IS - 2 SN - 1079-5014 KW - Gerontology And Geriatrics KW - Cerebrovascular burden KW - Education KW - Mood KW - Academic achievement KW - Brain KW - Burden KW - Cognitive functioning KW - Dementia KW - Depression KW - Elderly women KW - Older women KW - Retirement KW - Symptoms KW - Vascular depression KW - Women UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665163983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journals+of+Gerontology.+Series+B%2C+Psychological+Sciences+and+Social+Sciences&rft.atitle=Does+Brain+Reserve+Protect+Older+Women+from+Vascular+Depression%3F&rft.au=Paulson%2C+Daniel%3BBowen%2C+Mary+Elizabeth%3BLichtenberg%2C+Peter+A&rft.aulast=Paulson&rft.aufirst=Daniel&rft.date=2014-03-01&rft.volume=69&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=The+Journals+of+Gerontology.+Series+B%2C+Psychological+Sciences+and+Social+Sciences&rft.issn=10795014&rft_id=info:doi/10.1093%2Fgeronb%2Fgbt007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Brain Reserve N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1093/geronb/gbt007 ER - TY - JOUR T1 - Development and Initial Evaluation of a Web-Based Program to Increase Parental Awareness and Monitoring of Underage Alcohol Use: A Brief Report AN - 1550996797; 201406310 AB - The development of a Web-based parent-focused intervention to improve parental awareness and monitoring of adolescent alcohol use was preliminarily evaluated. Upon completion of baseline assessment, 67 parents were randomly assigned to the experimental Web-based parent-focused intervention or an assessment-only control condition. Participants who completed the experimental program, relative to control participants, significantly improved knowledge of problems related to underage drinking (p < .01) while improvements in overall monitoring of their children approached significance (p = .08). Improvements in monitoring by experimental participants, relative to controls, were pronounced in phone monitoring (p < .01) and indirect monitoring (p = .05). Participants in this study improved their communication about alcohol from pre- to post-intervention regardless of intervention. There were no statistical between-group differences found regarding underage drinking attitudes. This pilot evaluation demonstrates that this program warrants further examination in controlled trials with greater power. Study implications are discussed in light of results. Adapted from the source document. JF - Journal of Child & Adolescent Substance Abuse AU - Brown, Pamela C AU - Dunn, Michael E AU - Budney, Alan J AD - Orlando VA Medical Center, Orlando, FL, USA pamela.brown13@va.gov Y1 - 2014/03// PY - 2014 DA - March 2014 SP - 109 EP - 115 PB - Taylor & Francis, Philadelphia PA VL - 23 IS - 2 SN - 1067-828X, 1067-828X KW - Attitudes KW - Consciousness KW - Alcohol Abuse KW - Intervention KW - Childrearing Practices KW - Parents KW - Adolescents KW - Knowledge KW - Trials KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1550996797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+%26+Adolescent+Substance+Abuse&rft.atitle=Development+and+Initial+Evaluation+of+a+Web-Based+Program+to+Increase+Parental+Awareness+and+Monitoring+of+Underage+Alcohol+Use%3A+A+Brief+Report&rft.au=Brown%2C+Pamela+C%3BDunn%2C+Michael+E%3BBudney%2C+Alan+J&rft.aulast=Brown&rft.aufirst=Pamela&rft.date=2014-03-01&rft.volume=23&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+%26+Adolescent+Substance+Abuse&rft.issn=1067828X&rft_id=info:doi/10.1080%2F1067828X.2012.750553 LA - English DB - Social Services Abstracts N1 - Date revised - 2014-08-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JCAAFI N1 - SubjectsTermNotLitGenreText - Intervention; Alcohol Abuse; Childrearing Practices; Consciousness; Trials; Knowledge; Attitudes; Parents; Adolescents DO - http://dx.doi.org/10.1080/1067828X.2012.750553 ER - TY - JOUR T1 - Characteristics of diabetic patients associated with achieving and maintaining blood pressure targets in the Adherence and Intensification of Medications program AN - 1541982586; 201419180 AB - Objectives: To determine patient characteristics associated with achieving and sustaining blood pressure (BP) targets in the Adherence and Intensification of Medications program, a program led by pharmacists trained in motivational interviewing and authorized to make BP medication changes. Methods: We conducted a retrospective cohort study of patients with diabetes and persistent hypertension in Kaiser Permanente and the Department of Veterans Affairs. Using two-level logistic regression, baseline survey data from 458 program participants were examined to determine patient characteristics associated with (1) discharge from the program with a target BP (short-term success) and (2) maintenance of the target BP over a nine-month period (long-term success). Results: In multivariable analyses, patients who screened positive for depression or had a higher baseline systolic BP were less likely to achieve short-term success (adjusted odds ratio (AOR) 0.42 [95% confidence interval (CI): 0.19-0.93], p=0.03; AOR 0.94 [0.91-0.97], p<0.01; respectively). Patients who reported at baseline one or more barriers to medication adherence were less likely to achieve long-term success (AOR 0.50 [0.26-0.94], p=0.03). Conclusions: Although almost 90% of patients achieved short-term success, only 28% achieved long-term success. Baseline barriers to adherence were associated with lack of long-term success and could be the target of maintenance programs for patients who achieve short-term success. [Reprinted by permission of Sage Publications, Ltd., copyright holder.] JF - Chronic Illness AU - Klamerus, Mandi L AU - Kerr, Eve A AU - Bosworth, Hayden B AU - Schmittdiel, Julie A AU - Heisler, Michele AD - Center for Clinical Management Research, Veterans Affairs (VA) Ann Arbor Healthcare System, Ann Arbor, MI mandi.klamerus@va.gov Y1 - 2014/03// PY - 2014 DA - March 2014 SP - 60 EP - 73 PB - Sage Publications, London UK VL - 10 IS - 1 SN - 1742-3953, 1742-3953 KW - Blood pressure diabetes questionnaires medication adherence KW - Diabetics KW - Short term KW - Adherence KW - Confidence intervals KW - Blood pressure KW - Hypertension KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541982586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chronic+Illness&rft.atitle=Characteristics+of+diabetic+patients+associated+with+achieving+and+maintaining+blood+pressure+targets+in+the+Adherence+and+Intensification+of+Medications+program&rft.au=Klamerus%2C+Mandi+L%3BKerr%2C+Eve+A%3BBosworth%2C+Hayden+B%3BSchmittdiel%2C+Julie+A%3BHeisler%2C+Michele&rft.aulast=Klamerus&rft.aufirst=Mandi&rft.date=2014-03-01&rft.volume=10&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Chronic+Illness&rft.issn=17423953&rft_id=info:doi/10.1177%2F1742395313496590 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-07-01 N1 - Number of references - 39 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Short term; Adherence; Blood pressure; Diabetics; Hypertension; Confidence intervals DO - http://dx.doi.org/10.1177/1742395313496590 ER - TY - JOUR T1 - A kinetic analysis of the inhibition of FOX-4 [beta]-lactamase, a plasmid-mediated AmpC cephalosporinase, by monocyclic [beta]-lactams and carbapenems AN - 1505342671; 19339654 AB - Objectives Class C beta -lactamases are prevalent among Enterobacteriaceae; however, these enzymes are resistant to inactivation by commercially available beta -lactamase inhibitors. In order to find novel scaffolds to inhibit class C beta -lactamases, the comparative efficacy of monocyclic beta -lactam antibiotics (aztreonam and the siderophore monosulfactam BAL30072), the bridged monobactam beta -lactamase inhibitor BAL29880, and carbapenems (imipenem, meropenem, doripenem and ertapenem) were tested in kinetic assays against FOX-4, a plasmid-mediated class C beta -lactamase (pmAmpC). Methods The FOX-4 beta -lactamase was purified. Steady-state kinetics, electrospray ionization mass spectrometry (ESI-MS) and ultraviolet difference (UVD) spectroscopy were conducted using the beta -lactam scaffolds described. Results The K sub(i) values for the monocyclic beta -lactams against FOX-4 beta -lactamase were 0.04 plus or minus 0.01 mu M (aztreonam) and 0.66 plus or minus 0.03 mu M (BAL30072), and the K sub(i) value for the bridged monobactam BAL29880 was 8.9 plus or minus 0.5 mu M. For carbapenems, the K sub(i) values ranged from 0.27 plus or minus 0.05 mu M (ertapenem) to 2.3 plus or minus 0.3 mu M (imipenem). ESI-MS demonstrated the formation of stable covalent adducts when the monocyclic beta -lactams and carbapenems were reacted with FOX-4 beta -lactamase. UVD spectroscopy suggested the appearance of different chromophoric intermediates. Conclusions Monocyclic beta -lactam and carbapenem antibiotics are effective mechanism-based inhibitors of FOX-4 beta -lactamase, a clinically important pmAmpC, and provide stimulus for the development of new inhibitors to inactivate plasmidic and chromosomal class C beta -lactamases. JF - Journal of Antimicrobial Chemotherapy AU - Papp-Wallace, Krisztina M AU - Mallo, Susana AU - Bethel, Christopher R AU - Taracila, Magdalena A AU - Hujer, Andrea M AU - Fernandez, Ana AU - Gatta, Julian A AU - Smith, Kerri M AU - Xu, Yan AU - Page, Malcolm G P AU - Desarbre, Eric AU - Bou, German AU - Bonomo, Robert A AD - 1 Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA, robert.bonomo@va.gov Y1 - 2014/03// PY - 2014 DA - Mar 2014 SP - 682 EP - 690 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 69 IS - 3 SN - 0305-7453, 0305-7453 KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Aztreonam KW - beta -Lactamase KW - Adducts KW - ertapenem KW - Carbapenems KW - Enzymes KW - Antibiotics KW - Spectroscopy KW - Mass spectroscopy KW - scaffolds KW - Siderophores KW - Imipenem KW - Cephalosporinase KW - U.V. radiation KW - Kinetics KW - Meropenem KW - beta -Lactam antibiotics KW - Enterobacteriaceae KW - A 01340:Antibiotics & Antimicrobials KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1505342671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=A+kinetic+analysis+of+the+inhibition+of+FOX-4+%5Bbeta%5D-lactamase%2C+a+plasmid-mediated+AmpC+cephalosporinase%2C+by+monocyclic+%5Bbeta%5D-lactams+and+carbapenems&rft.au=Papp-Wallace%2C+Krisztina+M%3BMallo%2C+Susana%3BBethel%2C+Christopher+R%3BTaracila%2C+Magdalena+A%3BHujer%2C+Andrea+M%3BFernandez%2C+Ana%3BGatta%2C+Julian+A%3BSmith%2C+Kerri+M%3BXu%2C+Yan%3BPage%2C+Malcolm+G+P%3BDesarbre%2C+Eric%3BBou%2C+German%3BBonomo%2C+Robert+A&rft.aulast=Papp-Wallace&rft.aufirst=Krisztina&rft.date=2014-03-01&rft.volume=69&rft.issue=3&rft.spage=682&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkt434 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-03-01 N1 - Last updated - 2014-07-10 N1 - SubjectsTermNotLitGenreText - Aztreonam; beta -Lactamase; Adducts; ertapenem; Enzymes; Carbapenems; Antibiotics; Spectroscopy; scaffolds; Mass spectroscopy; Imipenem; Siderophores; U.V. radiation; Cephalosporinase; Meropenem; Kinetics; beta -Lactam antibiotics; Enterobacteriaceae DO - http://dx.doi.org/10.1093/jac/dkt434 ER - TY - JOUR T1 - Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit. AN - 1504149996; 23939022 AB - The gut mucosal immune system is considered to play an important role in counteracting potential adverse effects of food-derived antigens including nanovesicles. Whether nanovesicles naturally released from edible fruit work in a coordinated manner with gut immune cells to maintain the gut in a noninflammatory status is not known. Here, as proof of concept, we demonstrate that grapefruit-derived nanovesicles (GDNs) are selectively taken up by intestinal macrophages and ameliorate dextran sulfate sodium (DSS)-induced mouse colitis. These effects were mediated by upregulating the expression of heme oxygenase-1 (HO-1) and inhibiting the production of IL-1β and TNF-α in intestinal macrophages. The inherent biocompatibility and biodegradability, stability at wide ranges of pH values, and targeting of intestinal macrophages led us to further develop a novel GDN-based oral delivery system. Incorporating methotrexate (MTX), an anti-inflammatory drug, into GDNs and delivering the MTX-GDNs to mice significantly lowered the MTX toxicity when compared with free MTX, and remarkably increased its therapeutic effects in DSS-induced mouse colitis. These findings demonstrate that GDNs can serve as immune modulators in the intestine, maintain intestinal macrophage homeostasis, and can be developed for oral delivery of small molecule drugs to attenuate inflammatory responses in human disease. JF - Molecular therapy : the journal of the American Society of Gene Therapy AU - Wang, Baomei AU - Zhuang, Xiaoying AU - Deng, Zhong-Bin AU - Jiang, Hong AU - Mu, Jingyao AU - Wang, Qilong AU - Xiang, Xiaoyu AU - Guo, Haixun AU - Zhang, Lifeng AU - Dryden, Gerald AU - Yan, Jun AU - Miller, Donald AU - Zhang, Huang-Ge AD - James Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA. ; 1] Department of Diagnostic Radiology, University of Louisville, Louisville, Kentucky, USA [2] Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, Kentucky, USA. ; Department of Medicine, University of Louisville, Louisville, Kentucky, USA. ; 1] James Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA [2] Department of Microbiology & Immunology, University of Louisville, Louisville, Kentucky, USA [3] Louisville Veterans Administration Medical Center, Louisville, Kentucky, USA. Y1 - 2014/03// PY - 2014 DA - March 2014 SP - 522 EP - 534 VL - 22 IS - 3 KW - Anti-Inflammatory Agents KW - 0 KW - Interleukin-1beta KW - Plant Extracts KW - Tumor Necrosis Factor-alpha KW - Dextran Sulfate KW - 9042-14-2 KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Animals KW - Macrophages -- immunology KW - Humans KW - Molecular Targeted Therapy KW - Disease Models, Animal KW - Mice KW - Heme Oxygenase-1 -- metabolism KW - Mice, Inbred C57BL KW - Gene Expression Regulation KW - Tumor Necrosis Factor-alpha -- metabolism KW - Inflammatory Bowel Diseases -- immunology KW - Interleukin-1beta -- immunology KW - Male KW - Inflammatory Bowel Diseases -- drug therapy KW - Macrophages -- metabolism KW - Citrus paradisi -- chemistry KW - Nanostructures -- administration & dosage KW - Intestinal Mucosa -- metabolism KW - Drug Delivery Systems -- methods KW - Colitis -- chemically induced KW - Anti-Inflammatory Agents -- administration & dosage KW - Colitis -- drug therapy KW - Methotrexate -- administration & dosage KW - Plant Extracts -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504149996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+therapy+%3A+the+journal+of+the+American+Society+of+Gene+Therapy&rft.atitle=Targeted+drug+delivery+to+intestinal+macrophages+by+bioactive+nanovesicles+released+from+grapefruit.&rft.au=Wang%2C+Baomei%3BZhuang%2C+Xiaoying%3BDeng%2C+Zhong-Bin%3BJiang%2C+Hong%3BMu%2C+Jingyao%3BWang%2C+Qilong%3BXiang%2C+Xiaoyu%3BGuo%2C+Haixun%3BZhang%2C+Lifeng%3BDryden%2C+Gerald%3BYan%2C+Jun%3BMiller%2C+Donald%3BZhang%2C+Huang-Ge&rft.aulast=Wang&rft.aufirst=Baomei&rft.date=2014-03-01&rft.volume=22&rft.issue=3&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Molecular+therapy+%3A+the+journal+of+the+American+Society+of+Gene+Therapy&rft.issn=1525-0024&rft_id=info:doi/10.1038%2Fmt.2013.190 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-03 N1 - Date created - 2014-03-03 N1 - Date revised - 2017-01-24 N1 - SuppNotes - Cited By: FASEB J. 2010 Jun;24(6):1866-78 [20097877] J Exp Med. 2010 May 10;207(5):1045-56 [20385749] Mol Ther. 2010 Sep;18(9):1606-14 [20571541] Nat Mater. 2010 Nov;9(11):923-8 [20935658] J Exp Med. 2010 Dec 20;207(13):2843-54 [21098096] J Immunol. 2011 May 1;186(9):5506-13 [21444764] Proc Natl Acad Sci U S A. 2011 May 24;108(21):8743-8 [21555560] J Clin Invest. 2011 Jun;121(6):2242-53 [21606592] Science. 2011 Oct 14;334(6053):255-8 [21998396] Mucosal Immunol. 2012 May;5(3):232-9 [22318493] AAPS J. 2012 Jun;14(2):282-95 [22407288] Hepatology. 2013 Mar;57(3):1250-61 [22991247] Nat Commun. 2013;4:1867 [23695661] Mol Ther. 2013 Jul;21(7):1345-57 [23752315] Br J Nutr. 2013 Aug;110(4):599-608 [23506745] Mol Nutr Food Res. 2011 Feb;55(2):239-46 [20824662] J Clin Invest. 2000 Feb;105(4):469-78 [10683376] Biotechnol Bioeng. 2001 Jan 20;72(2):194-204 [11114657] J Immunol. 2001 Apr 1;166(7):4465-72 [11254702] J Immunol. 2001 Sep 1;167(5):2911-20 [11509639] Nat Med. 2002 Mar;8(3):240-6 [11875494] Development. 2002 Jun;129(11):2619-28 [12015290] Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:483-93 [12432938] Nature. 2003 Mar 6;422(6927):37-44 [12621426] Biochem J. 2004 May 15;380(Pt 1):161-71 [14965343] Crit Rev Food Sci Nutr. 1992;32(3):275-97 [1418603] Nat Med. 1999 Aug;5(8):900-6 [10426313] Can J Biochem Physiol. 1959 Aug;37(8):911-7 [13671378] Adv Drug Deliv Rev. 2005 Jan 6;57(2):247-65 [15555741] Gut. 2005 Jul;54(7):966-71 [15951544] J Med Chem. 2005 Sep 22;48(19):5892-9 [16161993] J Immunol. 2005 Nov 15;175(10):6900-8 [16272349] Lipids. 2005 Aug;40(8):773-85 [16296396] J Immunol. 2006 Feb 1;176(3):1375-85 [16424164] Am J Physiol Gastrointest Liver Physiol. 2006 Dec;291(6):G1062-70 [17038629] Exp Biol Med (Maywood). 2007 Jan;232(1):1-2 [17202580] Nat Immunol. 2007 Oct;8(10):1086-94 [17873879] Br J Nutr. 2007 Oct;98 Suppl 1:S59-63 [17922962] PLoS Pathog. 2008 Jun;4(6):e1000087 [18551172] J Biomater Sci Polym Ed. 2008;19(12):1549-70 [19017470] J Liposome Res. 2009;19(3):207-19 [19548842] J Autoimmun. 2010 May;34(3):J226-33 [20096538] Immunity. 2010 Mar 26;32(3):403-13 [20226692] Gut. 2010 Sep;59(9):1192-9 [20442201] N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1038/mt.2013.190 ER - TY - JOUR T1 - Characterization of N-glycosylation sites on the extracellular domain of NOX1/NADPH oxidase. AN - 1501836243; 24361341 AB - Extensive evidence demonstrates the pathophysiological importance of NOX1, the catalytic subunit of superoxide-generating enzyme NADPH oxidase, as a source of reactive oxygen species in nonphagocytic cells. However, the biochemical properties of NOX1 have not been extensively characterized due to a lack of specific immunological tools. We used a newly raised NOX1 polyclonal antibody to investigate posttranslational modifications of NOX1 overexpressed in cultured cells and in the colon, where endogenous NOX1 is highly expressed. Immunoblots of lysates from cells expressing NOX1 revealed a doublet of 56 and 60kDa accompanied by a broad band of 60-90kDa. Based on differential sensitivity to glycosidases, the doublet was identified as two high-mannose-type glycoforms of NOX1, whereas the broad band represented NOX1 with complex-type N-linked oligosaccharides. Deglycosylated NOX1 migrated at ~53kDa and N-glycosylation was demonstrated in NOX1 derived from both rat and human. Site-directed mutagenesis identified N-glycosylation sites at Asn(161) and Asn(241) on the extracellular loop of mouse NOX1. Elimination of N-glycosylation on NOX1 did not affect its electron transferase activity, protein stability, targeting to the cell surface, or localization in F-actin-positive membrane protrusions. Taken together, these data identify the two specific sites of N-linked glycosylation of murine NOX1 and demonstrate that they are not required for normal enzyme activity, protein stability, and membrane trafficking. As is true for NOX2, the contribution of glycosylation in NOX1 to its biologic function(s) merits further study. Copyright © 2013 Elsevier Inc. All rights reserved. JF - Free radical biology & medicine AU - Matsumoto, Misaki AU - Katsuyama, Masato AU - Iwata, Kazumi AU - Ibi, Masakazu AU - Zhang, Jia AU - Zhu, Kai AU - Nauseef, William M AU - Yabe-Nishimura, Chihiro AD - Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. Electronic address: m-matsu@koto.kpu-m.ac.jp. ; Radioisotope Center, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. ; Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. ; Inflammation Program and Department of Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Coralville, IA 52241, USA; Veterans Administration Medical Center, Iowa City, IA 52240, USA. Y1 - 2014/03// PY - 2014 DA - March 2014 SP - 196 EP - 204 VL - 68 KW - Actins KW - 0 KW - Membrane Glycoproteins KW - Reactive Oxygen Species KW - NOX1 protein, human KW - EC 1.6.3.- KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Index Medicus KW - Site-directed mutagenesis KW - Antibodies KW - Reactive oxygen species KW - N-glycosylation KW - NADPH oxidase KW - Rats KW - Mutagenesis, Site-Directed KW - Membrane Glycoproteins -- chemistry KW - Animals KW - Cells, Cultured KW - Humans KW - Colon -- metabolism KW - Mice KW - Glycosylation KW - Protein Structure, Tertiary KW - Membrane Glycoproteins -- metabolism KW - NADPH Oxidase -- metabolism KW - Reactive Oxygen Species -- metabolism KW - NADPH Oxidase -- chemistry KW - Actins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1501836243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Characterization+of+N-glycosylation+sites+on+the+extracellular+domain+of+NOX1%2FNADPH+oxidase.&rft.au=Matsumoto%2C+Misaki%3BKatsuyama%2C+Masato%3BIwata%2C+Kazumi%3BIbi%2C+Masakazu%3BZhang%2C+Jia%3BZhu%2C+Kai%3BNauseef%2C+William+M%3BYabe-Nishimura%2C+Chihiro&rft.aulast=Matsumoto&rft.aufirst=Misaki&rft.date=2014-03-01&rft.volume=68&rft.issue=&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2013.12.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-21 N1 - Date created - 2014-02-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2013.12.013 ER - TY - JOUR T1 - Aerobic exercise protects retinal function and structure from light-induced retinal degeneration. AN - 1499147839; 24523530 AB - Aerobic exercise is a common intervention for rehabilitation of motor, and more recently, cognitive function (Intlekofer and Cotman, 2013; Wood et al., 2012). While the underlying mechanisms are complex, BDNF may mediate much of the beneficial effects of exercise to these neurons (Ploughman et al., 2007; Griffin et al., 2011; Real et al., 2013). We studied the effects of aerobic exercise on retinal neurons undergoing degeneration. We exercised wild-type BALB/c mice on a treadmill (10 m/min for 1 h) for 5 d/week or placed control mice on static treadmills. After 2 weeks of exercise, mice were exposed to either toxic bright light (10,000 lux) for 4 h to induce photoreceptor degeneration or maintenance dim light (25 lux). Bright light caused 75% loss of both retinal function and photoreceptor numbers. However, exercised mice exposed to bright light had 2 times greater retinal function and photoreceptor nuclei than inactive mice exposed to bright light. In addition, exercise increased retinal BDNF protein levels by 20% compared with inactive mice. Systemic injections of a BDNF tropomyosin-receptor-kinase (TrkB) receptor antagonist reduced retinal function and photoreceptor nuclei counts in exercised mice to inactive levels, effectively blocking the protective effects seen with aerobic exercise. The data suggest that aerobic exercise is neuroprotective for retinal degeneration and that this effect is mediated by BDNF signaling. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Lawson, Eric C AU - Han, Moon K AU - Sellers, Jana T AU - Chrenek, Micah A AU - Hanif, Adam AU - Gogniat, Marissa A AU - Boatright, Jeffrey H AU - Pardue, Machelle T AD - Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia 30322, and Rehab R&D Center, Atlanta Veterans Administration Medical Center, Decatur, Georgia 30033. Y1 - 2014/02/12/ PY - 2014 DA - 2014 Feb 12 SP - 2406 EP - 2412 VL - 34 IS - 7 KW - Brain-Derived Neurotrophic Factor KW - 0 KW - Index Medicus KW - photoreceptors KW - retinal degeneration KW - treadmill KW - exercise KW - brain-derived neurotrophic factor KW - neuroprotection KW - Light -- adverse effects KW - Animals KW - Enzyme-Linked Immunosorbent Assay KW - Mice KW - Mice, Inbred BALB C KW - Male KW - Retinal Degeneration -- prevention & control KW - Photoreceptor Cells, Vertebrate -- pathology KW - Photoreceptor Cells, Vertebrate -- metabolism KW - Brain-Derived Neurotrophic Factor -- biosynthesis KW - Physical Conditioning, Animal -- physiology KW - Photoreceptor Cells, Vertebrate -- radiation effects KW - Retinal Degeneration -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1499147839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Aerobic+exercise+protects+retinal+function+and+structure+from+light-induced+retinal+degeneration.&rft.au=Lawson%2C+Eric+C%3BHan%2C+Moon+K%3BSellers%2C+Jana+T%3BChrenek%2C+Micah+A%3BHanif%2C+Adam%3BGogniat%2C+Marissa+A%3BBoatright%2C+Jeffrey+H%3BPardue%2C+Machelle+T&rft.aulast=Lawson&rft.aufirst=Eric&rft.date=2014-02-12&rft.volume=34&rft.issue=7&rft.spage=2406&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.2062-13.2014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-04-02 N1 - Date created - 2014-02-13 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Neurochem Int. 2001 Jan;38(1):17-23 [10913684] Neurobiol Dis. 2013 Sep;57:47-55 [22750524] Physiol Behav. 2000 Sep 15;70(5):425-9 [11110995] Mol Vis. 2003 Jan 24;9:18-23 [12552255] Doc Ophthalmol. 2003 Jan;106(1):25-9 [12675482] J Neurochem. 2003 Oct;87(2):290-6 [14511106] Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4190-6 [15505074] Invest Ophthalmol. 1966 Oct;5(5):450-73 [5929286] Nature. 1969 Jul 12;223(5202):201-4 [4307228] Vis Neurosci. 1990 Oct;5(4):379-87 [2265151] Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11249-53 [1454803] Invest Ophthalmol Vis Sci. 1994 Mar;35(3):907-15 [8125754] J Comp Neurol. 1997 Sep 15;386(1):149-60 [9303531] Brain Res Mol Brain Res. 1998 Oct 30;61(1-2):147-53 [9795193] J Neurosci. 1999 Oct 15;19(20):8919-30 [10516311] Comp Med. 2005 Apr;55(2):175-82 [15884781] Neuroscience. 2005;133(3):853-61 [15896913] Retina. 2005 Dec;25(8 Suppl):S25-S26 [16374321] Eye (Lond). 2006 Jul;20(7):796-800 [16021186] Mol Vis. 2006;12:1706-14 [17213800] Brain Res. 2007 May 30;1150:207-16 [17382914] Exp Neurol. 2008 Jun;211(2):489-93 [18420199] Neuromolecular Med. 2008;10(2):108-17 [18286388] Invest Ophthalmol Vis Sci. 2009 Jan;50(1):101-6 [18566466] Exp Physiol. 2009 Oct;94(10):1062-9 [19666694] Metab Brain Dis. 2009 Dec;24(4):587-97 [19844781] Prog Retin Eye Res. 2010 Mar;29(2):113-34 [19951742] J Neurosci. 2010 Jun 23;30(25):8613-23 [20573907] Dev Neurosci. 2010 Aug;32(3):249-56 [20693803] Rev Bras Fisioter. 2010 Jul-Aug;14(4):344-50 [20949235] Acta Neurol Scand. 2011 Jan;123(1):13-9 [20199518] Neurosci Res. 2011 Feb;69(2):161-73 [20969897] Eur J Neurosci. 2011 Feb;33(3):383-90 [21198979] Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3017-22 [21282661] PLoS One. 2011;6(2):e16643 [21347437] Cells Tissues Organs. 2011;193(5):298-309 [21411964] J Clin Invest. 2011 May;121(5):1846-57 [21505263] Invest Ophthalmol Vis Sci. 2011 Jun;52(7):4223-30 [21467171] Physiol Behav. 2011 Oct 24;104(5):934-41 [21722657] Mech Ageing Dev. 2011 Nov-Dec;132(11-12):560-7 [21983475] Scand J Caring Sci. 2012 Mar;26(1):12-9 [21564154] Am J Physiol Endocrinol Metab. 2012 May 1;302(10):E1252-60 [22374757] Dev Neurobiol. 2012 May;72(5):688-98 [21805686] PLoS One. 2012;7(9):e44218 [22962604] PLoS One. 2012;7(11):e50726 [23209820] Nat Neurosci. 2013 Jan;16(1):42-7 [23242310] Doc Ophthalmol. 1998-1999;95(3-4):187-215 [10532405] Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13427-31 [10557337] Neuroscience. 2013 May 1;237:118-29 [23396085] Invest Ophthalmol Vis Sci. 2000 Nov;41(12):4014-21 [11053307] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1523/JNEUROSCI.2062-13.2014 ER - TY - JOUR T1 - Combination of Inhaled Corticosteroid and Bronchodilator-Induced Delirium in an Elderly Patient With Lung Disease AN - 1496880846; 19022892 AB - Steroid psychosis has been well described with oral glucocorticoids, however, our search of the literature did not identify an association between delirium and the combination of inhaled glucocorticoids and long-acting beta-agonists. We describe the occurrence of delirium with the combination of an inhaled glucocorticoid and bronchodilator. An elderly male described confusion and hallucinations within 1 week after initiation of budesonide/formoterol for chronic obstructive pulmonary disease. The combination inhaler was discontinued with resolution of symptoms. Several weeks later, the patient was hospitalized and restarted on the combination inhaler. The patient was alert and oriented on admission, however, confusion and hallucinations progressed throughout his hospital stay. The combination inhaler was discontinued and his confusion and hallucinations resolved by discharge. The temporal relationship of these events and a probable Naranjo association allows for reasonable assumption that the use of the budesonide/formoterol combination inhaler caused or contributed to the occurrences of delirium in this elderly patient. The onset of delirium was likely due to the systemic absorption of the glucocorticoid from lung deposition, complicated in an individual with several predisposing risk factors for delirium. Health care providers should be aware of this potential adverse drug reaction when prescribing inhaled medications to older patients at risk for delirium. JF - Journal of Pharmacy Practice AU - Moss, Jason M AU - Kemp, Debra W AU - Brown, Jamie N AD - Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center Durham, NC, USA, Campbell University College of Pharmacy and Health Sciences, Department of Pharmacy Practice, Buies Creek, NC, USA, jason.moss@va.gov Y1 - 2014/02// PY - 2014 DA - Feb 2014 SP - 79 EP - 83 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 27 IS - 1 SN - 0897-1900, 0897-1900 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Absorption KW - Mental disorders KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1496880846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmacy+Practice&rft.atitle=Combination+of+Inhaled+Corticosteroid+and+Bronchodilator-Induced+Delirium+in+an+Elderly+Patient+With+Lung+Disease&rft.au=Moss%2C+Jason+M%3BKemp%2C+Debra+W%3BBrown%2C+Jamie+N&rft.aulast=Moss&rft.aufirst=Jason&rft.date=2014-02-01&rft.volume=27&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmacy+Practice&rft.issn=08971900&rft_id=info:doi/10.1177%2F0897190013504963 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Number of references - 1 N1 - Last updated - 2014-03-10 N1 - SubjectsTermNotLitGenreText - Mental disorders DO - http://dx.doi.org/10.1177/0897190013504963 ER - TY - JOUR T1 - NAC1, A POZ/BTB protein interacts with Parkin and may contribute to Parkinson's disease. AN - 1490754554; 24231739 AB - Loss-of-function in the Parkin protein is thought to play a part in causing neuronal cell death in patients with Parkinson's disease. This study explores the effect of Parkin degradation, via the overexpression of nucleus accumbens 1 (NAC1), on cell viability. It was found that NAC1 and Parkin are co-localized within the cell and interact with one another, leading to a decrease in Parkin levels. Moreover, NAC1 down-regulates Parkin by presenting it for ubiquitin-dependent proteasome degradation, which causes a decrease in proteasomal activity in neuronal cells. Consequently, this decrease in proteasomal activity leads to an increase in the cells' susceptibility to proteasome inhibition-induced toxicity. It was also found that Parkin and NAC1 are key proteins found to be present mainly in the cytoplasm and are co-localized in neurons of Parkinson's disease patients. Interestingly, mutation in the POZ/BTB domain (Q23L) of NAC1 disrupts the co-localization and interaction of NAC1 with Parkin and it further abrogates the proteasome inhibition-induced toxicity. We further observed that co-transfection of the mutant form of NAC1 with Parkin reversed the proteasome activity and 20S proteasome protein levels. These results indicate a novel interaction between NAC1 and Parkin that leads to neuronal cell death, a main characteristic in Parkinson's disease. Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved. JF - Neuroscience AU - Korutla, L AU - Furlong, H A AU - Mackler, S A AD - Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: Korutla@mail.med.upenn.edu. ; Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. ; Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Philadelphia Veterans Administration Medical Center (VAMC), Philadelphia, PA 19104, USA. Y1 - 2014/01/17/ PY - 2014 DA - 2014 Jan 17 SP - 86 EP - 95 VL - 257 KW - Cysteine Proteinase Inhibitors KW - 0 KW - Leupeptins KW - Nacc1 protein, mouse KW - Nerve Tissue Proteins KW - Repressor Proteins KW - Ubiquitin-Protein Ligases KW - EC 2.3.2.27 KW - parkin protein KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - benzyloxycarbonylleucyl-leucyl-leucine aldehyde KW - RF1P63GW3K KW - Index Medicus KW - Parkinson’s disease KW - degradation KW - ubiquitin–proteasome system KW - aggregates KW - co-localization KW - phosphate-buffered saline KW - glyceraldehyde 3-phosphate dehydrogenase KW - UPS KW - PCR KW - PBS KW - 4′,6-diamidino-2-phenylindole KW - GAPDH KW - GST KW - nucleus accumbens KW - SDS–PAGE KW - DAPI KW - 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide KW - glutathione S-transferase KW - sodium dodecyl sulfate–polyacrylamide gel electrophoresis KW - co-immunoprecipitation KW - MTT KW - down-regulation KW - NAC KW - proteasome KW - PD KW - polymerase chain reaction KW - Animals KW - Central Nervous System -- metabolism KW - Humans KW - Glutathione Transferase -- metabolism KW - Immunoprecipitation KW - Mice KW - Parkinson Disease -- pathology KW - Cysteine Proteinase Inhibitors -- pharmacology KW - Leupeptins -- pharmacology KW - Aged, 80 and over KW - Cytoplasm -- metabolism KW - Brain -- pathology KW - Neurons -- cytology KW - Cell Line, Transformed KW - Male KW - Down-Regulation -- physiology KW - Down-Regulation -- genetics KW - Ubiquitin-Protein Ligases -- genetics KW - Repressor Proteins -- metabolism KW - Nerve Tissue Proteins -- metabolism KW - Ubiquitin-Protein Ligases -- metabolism KW - Nerve Tissue Proteins -- genetics KW - Down-Regulation -- drug effects KW - Repressor Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1490754554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=NAC1%2C+A+POZ%2FBTB+protein+interacts+with+Parkin+and+may+contribute+to+Parkinson%27s+disease.&rft.au=Korutla%2C+L%3BFurlong%2C+H+A%3BMackler%2C+S+A&rft.aulast=Korutla&rft.aufirst=L&rft.date=2014-01-17&rft.volume=257&rft.issue=&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=1873-7544&rft_id=info:doi/10.1016%2Fj.neuroscience.2013.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-08-26 N1 - Date created - 2013-12-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neuroscience.2013.11.001 ER - TY - JOUR T1 - What Promotes Wisdom in 12-Step Recovery? AN - 1520326769; 201409013 AB - Research investigations on 12-step groups such as Alcoholics Anonymous (AA) and Narcotics Anonymous (NA) have addressed a number of resources associated with 12-step recovery. However, little is known about the role of wisdom and whether aspects of 12-step participation might increase this resource among 12-step members. An exploratory analysis revealed that participants who reported having a 'spiritual awakening' and considered themselves 'members' of 12-step groups reported significantly higher levels of wisdom. Twelve-step meeting attendance was not significantly related to wisdom scores. Findings suggest certain aspects of 12-step involvement are associated with wisdom and may play a role in substance abuse recovery. Adapted from the source document. JF - Journal of Groups in Addiction & Recovery AU - DiGangi, Julia A AU - Majer, John M AU - Mendoza, Leslie AU - Droege, Jocelyn R AU - Jason, Leonard A AU - Contreras, Richard AD - The Boston Consortium, Harvard Medical School, Boston University, Boston, Massachusetts, USA julia.digangi@va.gov Y1 - 2014/01/02/ PY - 2014 DA - 2014 Jan 02 SP - 31 EP - 39 PB - Haworth/Taylor & Francis, Philadelphia PA VL - 9 IS - 1 SN - 1556-035X, 1556-035X KW - Narcotics Anonymous KW - Recovery KW - Wisdom KW - Alcoholics Anonymous KW - Substance abuse KW - Twelve step model KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520326769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Groups+in+Addiction+%26+Recovery&rft.atitle=What+Promotes+Wisdom+in+12-Step+Recovery%3F&rft.au=DiGangi%2C+Julia+A%3BMajer%2C+John+M%3BMendoza%2C+Leslie%3BDroege%2C+Jocelyn+R%3BJason%2C+Leonard+A%3BContreras%2C+Richard&rft.aulast=DiGangi&rft.aufirst=Julia&rft.date=2014-01-02&rft.volume=9&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Journal+of+Groups+in+Addiction+%26+Recovery&rft.issn=1556035X&rft_id=info:doi/10.1080%2F1556035X.2013.836869 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Twelve step model; Wisdom; Recovery; Substance abuse; Narcotics Anonymous; Alcoholics Anonymous DO - http://dx.doi.org/10.1080/1556035X.2013.836869 ER - TY - JOUR T1 - Sustainability of Quality Improvement Following Removal of Pay-for-Performance Incentives AN - 1762377756; PQ0002419501 AB - BACKGROUND: Although pay-for-performance (P4P) has become a central strategy for improving quality in US healthcare, questions persist about the effectiveness of these programs. A key question is whether quality improvement that occurs as a result of P4P programs is sustainable, particularly if incentives are removed. OBJECTIVE: To investigate sustainability of performance levels following removal of performance-based incentives. DESIGN, SETTING, AND PARTICIPANTS: Observational cohort study that capitalized on a P4P program within the Veterans Health Administration (VA) that included adoption and subsequent removal of performance-based incentives for selected inpatient quality measures. The study sample comprised 128 acute care VA hospitals where performance was assessed between 2004 and 2010. INTERVENTION: VA system managers set annual performance goals in consultation with clinical leaders, and report performance scores to medical centers on a quarterly basis. These scores inform performance-based incentives for facilities and their managers. Bonuses are distributed based on the attainment of these performance goals. MEASUREMENTS: Seven quality of care measures for acute coronary syndrome, heart failure, and pneumonia linked to performance-based incentives. RESULTS: Significant improvements in performance were observed for six of seven quality of care measures following adoption of performance-based incentives and were maintained up to the removal of the incentive; subsequently, the observed performance levels were sustained. LIMITATIONS: This is a quasi-experimental study without a comparison group; causal conclusions are limited. CONCLUSION: The maintenance of performance levels after removal of a performance-based incentive has implications for the implementation of Medicare's value-based purchasing initiative and other P4P programs. Additional research is needed to better understand human and system-level factors that mediate sustainability of performance-based incentives. JF - Journal of General Internal Medicine AU - Benzer, Justin K AU - Young, Gary J AU - Burgess, James F AU - Baker, Errol AU - Mohr, David C AU - Charns, Martin P AU - Kaboli, Peter J AD - Center for Organization, Leadership, and Management Research (COLMR) at the VA Boston Healthcare System (152 M), 150 South Huntington Avenue, Boston, MA, 02860, USA, Justin.benzer@va.gov Y1 - 2014/01// PY - 2014 DA - January 2014 SP - 127 EP - 132 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 29 IS - 1 SN - 0884-8734, 0884-8734 KW - Sustainability Science Abstracts KW - Health care KW - Intervention KW - Incentives KW - Sustainability KW - Maintenance KW - Hospitals KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762377756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+General+Internal+Medicine&rft.atitle=Sustainability+of+Quality+Improvement+Following+Removal+of+Pay-for-Performance+Incentives&rft.au=Benzer%2C+Justin+K%3BYoung%2C+Gary+J%3BBurgess%2C+James+F%3BBaker%2C+Errol%3BMohr%2C+David+C%3BCharns%2C+Martin+P%3BKaboli%2C+Peter+J&rft.aulast=Benzer&rft.aufirst=Justin&rft.date=2014-01-01&rft.volume=29&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Journal+of+General+Internal+Medicine&rft.issn=08848734&rft_id=info:doi/10.1007%2Fs11606-013-2572-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 17 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Health care; Intervention; Incentives; Maintenance; Sustainability; Hospitals DO - http://dx.doi.org/10.1007/s11606-013-2572-4 ER - TY - JOUR T1 - MEN'S MENTAL HEALTH AND SUICIDE AN - 1761686054; 201600904 AB - Suicide is one of the most important issues related to men's mental health (Bilsker & White 2011, Rutz & Rihmer 2007, Sher 2006). Suicide in men is a silent epidemic and an important contributor to men's mortality. Men commit suicide 3-10 times more often than women (Rutz & Rihmer 2007). They frequently use the highly lethal methods of firearms and hanging (Bilsker & White 2011). Male rates are greater than female rates at all ages. It is believed that suicidality in men is significantly influenced by socioeconomic factors such as income, wealth and employment status (Sher 2006). Adapted from the source document. JF - Psychiatria Danubina AU - Sher, Leo AD - James J. Peters Veterans' Administration Medical Center and Icahn School of Medicine at Mount Sinai, New York, NY, USA Leo.Sher@mssm.edu Y1 - 2014///0, PY - 2014 DA - 0, 2014 SP - 298 PB - Medicinska naklada, Cankarova 13, 10000 Zagreb, Croatia VL - 26 IS - 3 SN - 0353-5053, 0353-5053 KW - Whites KW - Epidemics KW - Mortality Rates KW - Firearms KW - Males KW - Wealth KW - Suicide KW - Mental Health KW - Females KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761686054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatria+Danubina&rft.atitle=MEN%27S+MENTAL+HEALTH+AND+SUICIDE&rft.au=Sher%2C+Leo&rft.aulast=Sher&rft.aufirst=Leo&rft.date=2014-01-01&rft.volume=26&rft.issue=3&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Psychiatria+Danubina&rft.issn=03535053&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Males; Suicide; Whites; Mental Health; Firearms; Wealth; Mortality Rates; Epidemics; Females ER - TY - JOUR T1 - A five-year self-sustainability analysis of nurse-administered HIV rapid testing in Veterans Affairs primary care AN - 1717493794; PQ0002006214 AB - In 2008, nurse-administered HIV oral rapid testing (RT) was introduced at the Veterans Affairs Primary Care Clinic in Downtown Los Angeles. Analysis at five years revealed variable yet increasing rates of HIV RT at that facility despite the fact that no post-launch support was provided by the implementation team. Qualitative interviews among stakeholders conducted at five years revealed the pre-existing implementation practices endemic to this clinic that facilitated this unprecedented success (e.g. history of positive quality improvement implementations, leadership support, clinician involvement at each step of the process to facilitate empowerment, ownership and feasible customisation of the implementation, cohesive communication among clinicians and leadership, training, efficient supply pathway, progressive performance feedback and ongoing encouragement). JF - International Journal of STD & AIDS AU - Knapp, Herschel AU - Hagedorn, Hildi AU - Anaya, Henry D AD - U.S. Department of Veterans Affairs, Health Services Research and Development, Los Angeles, CA, USA, Herschel.Knapp@va.gov PY - 2014 SP - 837 EP - 843 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 United States VL - 25 IS - 12 SN - 0956-4624, 0956-4624 KW - Health & Safety Science Abstracts; Sustainability Science Abstracts; Virology & AIDS Abstracts KW - HIV KW - AIDS KW - screening KW - diagnostic testing KW - rapid testing KW - point-of-care KW - USA, California, Los Angeles KW - Stakeholders KW - Historical account KW - Acquired immune deficiency syndrome KW - Training KW - Communication KW - Lead KW - Communications KW - Human immunodeficiency virus KW - Quality control KW - Empowerment KW - Feedback KW - Sexually transmitted diseases KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717493794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=A+five-year+self-sustainability+analysis+of+nurse-administered+HIV+rapid+testing+in+Veterans+Affairs+primary+care&rft.au=Knapp%2C+Herschel%3BHagedorn%2C+Hildi%3BAnaya%2C+Henry+D&rft.aulast=Knapp&rft.aufirst=Herschel&rft.date=2014-01-01&rft.volume=25&rft.issue=12&rft.spage=837&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/10.1177%2F0956462414521796 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Quality control; Communication; Feedback; Lead; Historical account; Stakeholders; Acquired immune deficiency syndrome; Communications; Training; Human immunodeficiency virus; Empowerment; Sexually transmitted diseases; USA, California, Los Angeles DO - http://dx.doi.org/10.1177/0956462414521796 ER - TY - JOUR T1 - Older Adult Experience of Online Diagnosis: Results From a Scenario-Based Think-Aloud Protocol AN - 1700661823; 201505913 AB - Background: Searching for online information to interpret symptoms is an increasingly prevalent activity among patients, even among older adults. As older adults typically have complex health care needs, their risk of misinterpreting symptoms via online self-diagnosis may be greater. However, limited research has been conducted with older adults in the areas of symptom interpretation and human-computer interaction. Objective: The intent of the study was to describe the processes that a sample of older adults may use to diagnose symptoms online as well as the processes that predict accurate diagnosis. Methods: We conducted a series of think-aloud protocols with 79 adults aged 50 years or older. Participants received one of two vignettes that depicted symptoms of illness. Participants talked out loud about their thoughts and actions while attempting to diagnose the symptoms with and without the help of common Internet tools (Google and WebMDs Symptom Checker). Think-aloud content was categorized using an adapted Q-sort and general inductive approach. We then compared the think-aloud content of participants who were accurate in their diagnosis with those who were not. Results: Nineteen descriptive codes were identified from the think-aloud content. The codes touched upon Web navigation, attempts to organize and evaluate online health information, and strategies to diagnose symptoms. Participants most frequently relied on a strategy where they reviewed and then rejected the online diagnoses if they contained additional symptoms than those that were depicted in the vignette. Finally, participants who were inaccurate in their diagnosis reported being confused by the diagnosis task, lacking confidence in their diagnosis, and using their past experiences with illness to guide diagnosis more frequently than those participants who accurately diagnosed the symptoms. Conclusions: Older adult participants tended to rely on matching strategies to interpret symptoms, but many still utilized existing medical knowledge and previous illness experiences as a guide for diagnosis. Many participants also had difficulty navigating the Internet tools, which suggests an increased need for navigation aids in Web design. Furthermore, participants who were inaccurate in their diagnosis had more difficulty with the Internet tools and confusion with the task than those who were accurate. Future work in this area may want to utilize additional study design such as eye-tracking to further understand the coordination between Web navigation, online symptom information processing, and diagnostic strategies. Adapted from the source document. JF - Journal of Medical Internet Research AU - Luger, Tana M AU - Houston, Thomas K AU - Suls, Jerry AD - eHealth Quality Enhancement Research Initiative, Center for Healthcare Organization and Implementation Research, Edith Nourse Rogers Memorial Veteran's Hospital, Bedford, MA, United States at va.gov Y1 - 2014///0, PY - 2014 DA - 0, 2014 PB - Gunther Eysenbach MD MPH, Associate Professor, University of Toronto Senior Scientist, Centre for Global eHealth Innovation, Toronto, Canada VL - 16 IS - 1 SN - 1438-8871, 1438-8871 KW - information seeking behavior KW - Internet KW - age factors KW - Information communication KW - Diagnosis KW - Web site design KW - Medicine KW - Old people KW - article KW - 10.13: INFORMATION COMMUNICATION - SCIENCE, TECHNOLOGY, MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700661823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Internet+Research&rft.atitle=Older+Adult+Experience+of+Online+Diagnosis%3A+Results+From+a+Scenario-Based+Think-Aloud+Protocol&rft.au=Luger%2C+Tana+M%3BHouston%2C+Thomas+K%3BSuls%2C+Jerry&rft.aulast=Luger&rft.aufirst=Tana&rft.date=2014-01-01&rft.volume=16&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Internet+Research&rft.issn=14388871&rft_id=info:doi/10.2196%2Fjmir.2924 L2 - http://www.jmir.org/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-08-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Diagnosis; Old people; Information communication; Medicine; Web site design DO - http://dx.doi.org/10.2196/jmir.2924 ER - TY - JOUR T1 - Warfarin Pharmacogenomics: Recommendations With Available Patented Clinical Technologies AN - 1676356179; PQ0001455971 AB - Warfarin pharmacogenomic testing has become a prime example of the utility of personalized molecular testing in the modern clinical laboratory. Warfarin is a commonly used drug for the prevention and treatment of thromboembolic complications in a variety of clinical situations. However, a number of factors lead to a high interindividual variability in dose requirements. Among the primary factors in this variability are genetic polymorphisms in general patient populations, which can account for 35-50% of varying dose requirements among patients. In this review, we discuss the implications of polymorphisms in the cytochrome P-450 enzyme 2C9 (CYP2C9) and Vitamin K Epoxide Reductase Enzyme Complex subunit 1 (VKORC1) as they relate to therapeutic warfarin dosing. We discuss the clinical utility of pharmacogenomics testing as related to warfarin dosing, and propose a clinical model for the implementation of the pharmacogenomic test results. Finally, we provide a brief overview of the currently available commercial testing platforms with discussion of the complexities of utilizing patented methodologies in bringing genetic testing such as this to the clinical laboratory. JF - Recent Patents on Biotechnology AU - Borkowski, Andrew A AU - Kardani, Avni AU - Mastorides, Stephen M AU - Thomas, L Brannon AD - James A. Haley VA Medical Center, Tampa, Florida 33612, USA; University of South Florida College of Medicine, Tampa, Florida 33612, USA; P&LMS (113), 13000 Bruce B. Downs Blvd, Tampa, FL 33612, USA, Andrew.borkowski@va.gov Y1 - 2014///0, PY - 2014 DA - 0, 2014 SP - 110 EP - 115 PB - Bentham Science Publishers Ltd. VL - 8 IS - 2 SN - 1872-2083, 1872-2083 KW - Biotechnology and Bioengineering Abstracts KW - Biotechnology |a MeSH KW - patents |a MeSH KW - pharmacogenomics |a MeSH KW - pharmacogenetics |a MeSH KW - warfarin |a MeSH KW - Cytochromes KW - Epoxides KW - pharmacogenomics KW - Gene polymorphism KW - Enzymes KW - Warfarin KW - Thromboembolism KW - Models KW - reductase KW - Reviews KW - Vitamin K KW - Genetic screening KW - Drugs KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676356179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+Patents+on+Biotechnology&rft.atitle=Warfarin+Pharmacogenomics%3A+Recommendations+With+Available+Patented+Clinical+Technologies&rft.au=Borkowski%2C+Andrew+A%3BKardani%2C+Avni%3BMastorides%2C+Stephen+M%3BThomas%2C+L+Brannon&rft.aulast=Borkowski&rft.aufirst=Andrew&rft.date=2014-01-01&rft.volume=8&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Recent+Patents+on+Biotechnology&rft.issn=18722083&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Cytochromes; Epoxides; pharmacogenomics; Gene polymorphism; Enzymes; Warfarin; Thromboembolism; Models; reductase; Reviews; Vitamin K; Genetic screening; Drugs ER - TY - JOUR T1 - Technology-Assisted Patient Access to Clinical Information: An Evaluation Framework for Blue Button AN - 1665162512 AB - Background: Patient access to clinical information represents a means to improve the transparency and delivery of health care as well as interactions between patients and health care providers. We examine the movement toward augmenting patient access to clinical information using technology. Our analysis focuses on "Blue Button," a tool that many health care organizations are implementing as part of their Web-based patient portals. Objective: We present a framework for evaluating the effects that technology-assisted access to clinical information may have on stakeholder experiences, processes of care, and health outcomes. Methods: A case study of the United States Department of Veterans Affairsʼ (VA) efforts to make increasing amounts of clinical information available to patients through Blue Button. Drawing on established collaborative relationships with researchers, clinicians, and operational partners who are engaged in the VAʼs ongoing implementation and evaluation efforts related to Blue Button, we assessed existing evidence and organizational practices through key informant interviews, review of docmnents and other available materials, and an environmental scan of published literature and the websites of other health care organizations. Results: Technology-assisted access to clinical information represents a significant advance for VA patients and marks a significant change for the VA as an organization. Evaluations of Blue Button should (1) consider both processes of care and outcomes, (2) clearly define constmcts of focus, (3) examine influencing factors related to the patient population and clinical context, and (4) identify potential unintended consequences. JF - Journal of Medical Internet Research AU - Hogan, Timothy P AU - Nazi, Kim M AU - Lager, Tana M AU - Amante, Daniel J AU - Smith, Bridget M AU - Barker, Anna AU - Shimada, Stephanie L AU - Volkman, Julie E AU - Garvin, Lynn AU - Simon, Steven R AU - Houston, Thomas K AD - Center for Healthcare Organization and Implementation Research (CHOIR), eHealth Quality Enhancement Research Initiative (QUERI), National eHealth QUERI Coordinating Center, Building 70, 200 Springs Road, Bedford, MA, 01730, United States; Division of Health Informatics and Implementation Science, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, United States ; Veterans and Consumers Health Informatics Office, Office of Informatics and Analytics, Veterans Health Administration, US Department of Veterans Affairs, Washington, DC, United States ; Center for Healthcare Organization and Implementation Research (CHOIR), eHealth Quality Enhancement Research Initiative (QUERI), National eHealth QUERI Coordinating Center, Bedford, MA, United States; Division of Health Informatics and Implementation Science, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, United States ; Division of Health Informatics and Implementation Science, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, United States ; Center of Innovation for Complex Chronic Healthcare (CINCCH), Spinal Cord Injury Quality Enhancement Research Initiative (QUERI), Hines VAMC, Chicago, IL, United States; Program in Health Services Research, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, United States ; Center for Healthcare Organization and Implementation Research (CHOIR), eHealth Quality Enhancement Research Initiative (QUERI), National eHealth QUERI Coordinating Center, Bedford, MA, United States ; Center for Healthcare Organization and Implementation Research (CHOIR), eHealth Quality Enhancement Research Initiative (QUERI), National eHealth QUERI Coordinating Center, Bedford, MA, United States; Department of Health Policy and Management, School of Public Health, Boston University School of Public Health, Boston, MA, United States ; Section of General Internal Medicine, VA Boston Healthcare System, Boston, MA, United States; The Heller School for Social Policy and Management, Brandeis University, Waltham, MA, United States ; Center for Healthcare Organization and Implementation Research (CHOIR), eHealth Quality Enhancement Research Initiative (QUERI), National eHealth QUERI Coordinating Center, Building 70, 200 Springs Road, Bedford, MA, 01730, United States; Division of Health Informatics and Implementation Science, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, United States, Section of General Internal Medicine, VA Boston Healthcare System, Boston, MA, United States; Division of General Internal Medicine and Primary Care, Brigham and Womenʼs Hospital, Boston, MA, United States ; Center for Healthcare Organization and Implementation Research (CHOIR), eHealth Quality Enhancement Research Initiative (QUERI), National eHealth QUERI Coordinating Center, Building 70, 200 Springs Road, Bedford, MA, 01730, United States; Division of Health Informatics and Implementation Science, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, United States, Center for Healthcare Organization and Implementation Research (CHOIR), eHealth Quality Enhancement Research Initiative (QUERI), National eHealth QUERI Coordinating Center, Bedford, MA, United States; Division of Health Informatics and Implementation Science, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, United States ; Center for Healthcare Organization and Implementation Research (CHOIR), eHealth Quality Enhancement Research Initiative (QUERI), National eHealth QUERI Coordinating Center, Building 70, 200 Springs Road, Bedford, MA, 01730, United States; Division of Health Informatics and Implementation Science, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, United States Y1 - 2014 PY - 2014 DA - 2014 CY - Toronto PB - Gunther Eysenbach MD MPH, Associate Professor VL - 16 IS - 3 SN - 1438-8871 KW - Medical Sciences--Computer Applications KW - Clinical outcomes KW - Health professionals KW - Health care KW - Care delivery KW - Clinical information KW - Computer based KW - Health status KW - Information technology KW - United States--US KW - Medical technology KW - Internet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665162512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Internet+Research&rft.atitle=Technology-Assisted+Patient+Access+to+Clinical+Information%3A+An+Evaluation+Framework+for+Blue+Button&rft.au=Hogan%2C+Timothy+P%3BNazi%2C+Kim+M%3BLager%2C+Tana+M%3BAmante%2C+Daniel+J%3BSmith%2C+Bridget+M%3BBarker%2C+Anna%3BShimada%2C+Stephanie+L%3BVolkman%2C+Julie+E%3BGarvin%2C+Lynn%3BSimon%2C+Steven+R%3BHouston%2C+Thomas+K&rft.aulast=Hogan&rft.aufirst=Timothy&rft.date=2014-01-01&rft.volume=16&rft.issue=3&rft.spage=%5Bnp%5D&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Internet+Research&rft.issn=14388871&rft_id=info:doi/10.2196%2Fresprot.3290 LA - eng DB - Applied Social Sciences Index & Abstracts (ASSIA); Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-01-09 N1 - Last updated - 2015-05-01 N1 - SubjectsTermNotLitGenreText - Care delivery; Clinical information; Clinical outcomes; Computer based; Health care; Health professionals; Health status; Information technology; Internet; Medical technology; United States--US DO - http://dx.doi.org/10.2196/resprot.3290 ER - TY - JOUR T1 - Topical application of a platelet activating factor receptor agonist suppresses phorbol ester-induced acute and chronic inflammation and has cancer chemopreventive activity in mouse skin. AN - 1622057212; 25375862 AB - Platelet activating factor (PAF) has long been associated with acute edema and inflammatory responses. PAF acts by binding to a specific G-protein coupled receptor (PAF-R, Ptafr). However, the role of chronic PAF-R activation on sustained inflammatory responses has been largely ignored. We recently demonstrated that mice lacking the PAF-R (Ptafr-/- mice) exhibit increased cutaneous tumorigenesis in response to a two-stage chemical carcinogenesis protocol. Ptafr-/- mice also exhibited increased chronic inflammation in response to phorbol ester application. In this present study, we demonstrate that topical application of the non-hydrolysable PAF mimetic (carbamoyl-PAF (CPAF)), exerts a potent, dose-dependent, and short-lived edema response in WT mice, but not Ptafr -/- mice or mice deficient in c-Kit (c-KitW-sh/W-sh mice). Using an ear inflammation model, co-administration of topical CPAF treatment resulted in a paradoxical decrease in both acute ear thickness changes associated with a single PMA application, as well as the sustained inflammation associated with chronic repetitive PMA applications. Moreover, mice treated topically with CPAF also exhibited a significant reduction in chemical carcinogenesis. The ability of CPAF to suppress acute and chronic inflammatory changes in response to PMA application(s) was PAF-R dependent, as CPAF had no effect on basal or PMA-induced inflammation in Ptafr-/- mice. Moreover, c-Kit appears to be necessary for the anti-inflammatory effects of CPAF, as CPAF had no observable effect in c-KitW-sh/W-sh mice. These data provide additional evidence that PAF-R activation exerts complex immunomodulatory effects in a model of chronic inflammation that is relevant to neoplastic development. JF - PloS one AU - Sahu, Ravi P AU - Rezania, Samin AU - Ocana, Jesus A AU - DaSilva-Arnold, Sonia C AU - Bradish, Joshua R AU - Richey, Justin D AU - Warren, Simon J AU - Rashid, Badri AU - Travers, Jeffrey B AU - Konger, Raymond L AD - Departments of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America. ; Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America. ; Departments of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America; Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America. ; Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America; Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, 46202, United States of America. Y1 - 2014 PY - 2014 DA - 2014 SP - 1 VL - 9 IS - 11 KW - Anti-Inflammatory Agents KW - 0 KW - Antineoplastic Agents KW - Phorbol Esters KW - Platelet Membrane Glycoproteins KW - Receptors, G-Protein-Coupled KW - platelet activating factor receptor KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Proto-Oncogene Proteins c-kit KW - EC 2.7.10.1 KW - Index Medicus KW - Proto-Oncogene Proteins c-kit -- metabolism KW - Animals KW - Epidermis -- drug effects KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Mice KW - Epidermis -- pathology KW - Ear KW - Proto-Oncogene Proteins c-kit -- genetics KW - Administration, Topical KW - Phorbol Esters -- adverse effects KW - Skin Neoplasms -- drug therapy KW - Antineoplastic Agents -- administration & dosage KW - Receptors, G-Protein-Coupled -- agonists KW - Skin Neoplasms -- chemically induced KW - Platelet Membrane Glycoproteins -- agonists KW - Inflammation -- chemically induced KW - Receptors, G-Protein-Coupled -- genetics KW - Platelet Membrane Glycoproteins -- genetics KW - Inflammation -- drug therapy KW - Anti-Inflammatory Agents -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622057212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Topical+application+of+a+platelet+activating+factor+receptor+agonist+suppresses+phorbol+ester-induced+acute+and+chronic+inflammation+and+has+cancer+chemopreventive+activity+in+mouse+skin.&rft.au=Sahu%2C+Ravi+P%3BRezania%2C+Samin%3BOcana%2C+Jesus+A%3BDaSilva-Arnold%2C+Sonia+C%3BBradish%2C+Joshua+R%3BRichey%2C+Justin+D%3BWarren%2C+Simon+J%3BRashid%2C+Badri%3BTravers%2C+Jeffrey+B%3BKonger%2C+Raymond+L&rft.aulast=Sahu&rft.aufirst=Ravi&rft.date=2014-01-01&rft.volume=9&rft.issue=11&rft.spage=e111608&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0111608 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-14 N1 - Date created - 2014-11-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Biol Chem. 2005 Oct 21;280(42):35448-57 [16115894] Mod Pathol. 2006 Jan;19(1):149-59 [16258517] Prog Biophys Mol Biol. 2006 Sep;92(1):108-18 [16564073] Prostaglandins Other Lipid Mediat. 2006 Jul;80(1-2):62-73 [16846787] J Invest Dermatol. 2007 Jun;127(6):1507-15 [17363918] Blood. 2007 Jun 15;109(12):5363-70 [17327401] Nat Immunol. 2007 Oct;8(10):1095-104 [17767162] Cancer Res. 2008 May 15;68(10):3978-84 [18483284] J Invest Dermatol. 2008 Jul;128(7):1780-7 [18200048] Prostaglandins Other Lipid Mediat. 2008 Dec;87(1-4):1-8 [18555720] J Immunol. 2009 Mar 1;182(5):2842-8 [19234179] J Allergy Clin Immunol. 2010 May;125(5):1137-1145.e6 [20392487] J Immunol. 2010 Jun 1;184(11):6327-34 [20421642] Eur J Immunol. 2010 Jul;40(7):1843-51 [20583030] Curr Opin Immunol. 2010 Oct;22(5):643-8 [20884193] Cell. 2011 Mar 4;144(5):646-74 [21376230] Cell Physiol Biochem. 2011;27(3-4):363-72 [21471725] Trends Immunol. 2011 Oct;32(10):478-85 [21917522] Clin Cancer Res. 2011 Nov 15;17(22):7015-23 [21976550] Respir Med. 2012 Jan;106(1):9-14 [22112783] Carcinogenesis. 2012 Mar;33(3):694-701 [22223848] Photochem Photobiol. 2012 Mar-Apr;88(2):490-3 [22211638] J Biol Chem. 2003 May 9;278(19):16614-21 [12601006] J Biol Chem. 2003 Nov 28;278(48):48228-35 [14500726] Crit Rev Clin Lab Sci. 2003 Dec;40(6):643-72 [14708958] J Immunol. 2004 May 15;172(10):6330-5 [15128823] J Natl Cancer Inst. 1982 Dec;69(6):1305-9 [6982995] J Immunol. 1985 Jan;134(1):548-55 [2578054] Agents Actions. 1987 Apr;20(3-4):165-8 [2440261] Agents Actions. 1989 Mar;26(3-4):335-41 [2567568] J Biol Chem. 1993 Mar 5;268(7):4573-6 [8383116] J Biol Chem. 1994 Jan 28;269(4):2814-9 [8300614] Inflammation. 1993 Dec;17(6):723-41 [8112831] J Invest Dermatol. 1995 Dec;105(6):816-23 [7490477] J Biol Chem. 1999 Sep 17;274(38):26917-21 [10480902] J Leukoc Biol. 2005 May;77(5):598-625 [15689384] Am J Pathol. 2005 Sep;167(3):835-48 [16127161] J Clin Invest. 2005 Oct;115(10):2855-61 [16184199] Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19977-82 [18077429] J Exp Med. 2008 Feb 18;205(2):275-85 [18208974] J Exp Med. 2008 Feb 18;205(2):267-70 [18268042] Carcinogenesis. 2008 Apr;29(4):880-6 [18258601] Exp Dermatol. 2012 Apr;21(4):241-8 [22276860] Res Vet Sci. 2012 Aug;93(1):393-7 [21820686] Carcinogenesis. 2012 Jul;33(7):1360-7 [22542595] Int J Cancer. 2012 Oct 1;131(7):E1055-66 [22467332] Blood. 2012 Sep 6;120(10):2042-54 [22837530] J Invest Dermatol. 2013 Jan;133(1):27-30 [22854621] Allergy. 2013 Feb;68(2):256-8 [23320562] Semin Immunopathol. 2013 Mar;35(2):245-54 [22993030] J Immunol. 2013 Mar 1;190(5):2447-54 [23355733] Joint Bone Spine. 2013 Mar;80(2):141-5 [23116710] J Immunol. 2013 May 1;190(9):4458-63 [23606723] J Immunol. 2013 Jun 1;190(11):5534-44 [23636054] Mediators Inflamm. 2013;2013:198193 [24062612] J Leukoc Biol. 2014 Jan;95(1):139-48 [24009177] Exp Dermatol. 2014 Mar;23(3):159-64 [24444017] Immunology. 2000 Feb;99(2):314-9 [10692052] Crit Care Med. 2000 Apr;28(4 Suppl):N27-36 [10807314] Free Radic Biol Med. 2000 Jun 15;28(12):1762-70 [10946218] Am J Pathol. 2002 Dec;161(6):2065-78 [12466123] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0111608 ER - TY - JOUR T1 - How robust is the association between smoking and depression in adults? A meta-analysis using linear mixed-effects models AN - 1611615390; 20692150 AB - Introduction: Our objective was to use meta-analytic techniques to assess the strength of the overall relationship and role of potential moderators in the association between smoking and depression in adults. Methods: Two popular health and social science databases (PubMed and PsycINFO) were systematically searched to identify studies which examined the association between adult smoking behavior and major depressive disorder (MOD) or depressive symptoms. A total of 85 relevant studies were selected for inclusion. Studies were analyzed using a linear mixed effects modeling package ("Ime4" for R) and the Comprehensive Meta-Analysis program version 2. Results: Multiple nested linear mixed-effects models were compared. The best fitting models were those that included only random study effects and smoking status. In cross-sectional studies, current smokers were more likely to be depressed than never smokers (OR = 1.50, Cl = 1.39-1.60), and current smokers were more likely to be depressed than former smokers (OR = 1.76, Cl = 1.48-2.09). The few available prospective studies, that used the requisite statistical adjustments, also showed smokers at baseline had greater odds of incident depression at follow-up than never smokers (OR = 1.62, Cl = 1.10-2.40). Conclusions: In cross-sectional studies, smoking was associated with a nearly two-fold increased risk of depression relative to both never smokers and former smokers. In the smaller set of prospective studies, the odds of subsequent depression were also higher for current than never smokers. Attesting to its robustness, the relationship between smoking and depression was exhibited across several moderators. Findings could help health care providers to more effectively anticipate co-occurring health issues of their patients. Several methodological recommendations for future research are offered. JF - Addictive Behaviors AU - Luger, Tana M AU - Suls, Jerry AU - Weg, Mark W Vander AD - Center for Healthcare Organization and Implementation Research, 200 Springs Road, Building 70 (152), Bedford, MA 02117, USA, Tana.Luger2@va.gov Y1 - 2014 PY - 2014 DA - 2014 SP - 1418 EP - 1429 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 39 IS - 10 SN - 0306-4603, 0306-4603 KW - Risk Abstracts KW - Smoking KW - Depression KW - Meta-analysis KW - Measurement KW - Risk assessment KW - Health care KW - Social sciences KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1611615390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+Behaviors&rft.atitle=How+robust+is+the+association+between+smoking+and+depression+in+adults%3F+A+meta-analysis+using+linear+mixed-effects+models&rft.au=Luger%2C+Tana+M%3BSuls%2C+Jerry%3BWeg%2C+Mark+W+Vander&rft.aulast=Luger&rft.aufirst=Tana&rft.date=2014-01-01&rft.volume=39&rft.issue=10&rft.spage=1418&rft.isbn=&rft.btitle=&rft.title=Addictive+Behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2014.05.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-10-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Risk assessment; Smoking; Depression; Health care; Social sciences DO - http://dx.doi.org/10.1016/j.addbeh.2014.05.011 ER - TY - JOUR T1 - Evidence for Bladder Urothelial Pathophysiology in Functional Bladder Disorders AN - 1566838403; 20727398 AB - Understanding of the role of urothelium in regulating bladder function is continuing to evolve. While the urothelium is thought to function primarily as a barrier for preventing injurious substances and microorganisms from gaining access to bladder stroma and upper urinary tract, studies indicate it may also function in cell signaling events relating to voiding function. This review highlights urothelial abnormalities in bladder pain syndrome/interstitial cystitis (BPS/IC), feline interstitial cystitis (FIC), and nonneurogenic idiopathic overactive bladder (OAB). These bladder conditions are typified by lower urinary tract symptoms including urinary frequency, urgency, urgency incontinence, nocturia, and bladder discomfort or pain. Urothelial tissues and cells from affected clinical subjects and asymptomatic controls have been compared for expression of proteins and mRNA. Animal models have also been used to probe urothelial responses to injuries of the urothelium, urethra, or central nervous system, and transgenic techniques are being used to test specific urothelial abnormalities on bladder function. BPS/IC, FIC, and OAB appear to share some common pathophysiology including increased purinergic, TRPV1, and muscarinic signaling, increased urothelial permeability, and aberrant urothelial differentiation. One challenge is to determine which of several abnormally regulated signaling pathways is most important for mediating bladder dysfunction in these syndromes, with a goal of treating these conditions by targeting specific pathophysiology. JF - BioMed Research International AU - Keay, Susan K AU - Birder, Lori A AU - Chai, Toby C AD - Division of Infectious Diseases, University of Maryland School of Medicine and the VA Maryland Health Care System, 10 North Greene Street, Room 3B-184, Baltimore, MD 21201, USA, susan.keay2@va.gov Y1 - 2014/01// PY - 2014 DA - Jan 2014 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2014 SN - 2314-6133, 2314-6133 KW - Biotechnology and Bioengineering Abstracts KW - Stroma KW - Central nervous system KW - Capsaicin receptors KW - Injuries KW - Urinary bladder KW - Acetylcholine receptors (muscarinic) KW - Animal models KW - Probes KW - Cystitis KW - Pain KW - urothelium KW - Urinary tract KW - mRNA KW - Differentiation KW - Permeability KW - Microorganisms KW - Signal transduction KW - Urethra KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566838403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Evidence+for+Bladder+Urothelial+Pathophysiology+in+Functional+Bladder+Disorders&rft.au=Keay%2C+Susan+K%3BBirder%2C+Lori+A%3BChai%2C+Toby+C&rft.aulast=Keay&rft.aufirst=Susan&rft.date=2014-01-01&rft.volume=2014&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2014%2F865463 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 1 N1 - Last updated - 2015-01-21 N1 - SubjectsTermNotLitGenreText - Stroma; Central nervous system; Injuries; Capsaicin receptors; Urinary bladder; Acetylcholine receptors (muscarinic); Probes; Animal models; Cystitis; urothelium; Pain; Urinary tract; mRNA; Permeability; Differentiation; Microorganisms; Urethra; Signal transduction DO - http://dx.doi.org/10.1155/2014/865463 ER - TY - JOUR T1 - Reliability and Practicality of Measuring Waist Circumference to Monitor Cardiovascular Risk Among Community Mental Health Center Patients AN - 1558990325; 201427832 AB - The aim of this study was to evaluate the clinical utility of measuring waist circumference (WC) in obese individuals with severe psychiatric disabilities. Reliability of the measure and researchers' comfort were assessed. Thirty outpatients with a diagnosis of schizophrenia or schizoaffective disorder were recruited from an urban community mental health center and WC was measured using two methods by three different raters. Inter- and intra-rater reliability was calculated. Raters reported on their comfort with obtaining WC. There was good inter-rater reliability and an acceptable rate of error independent of measurement location. Overall, raters were not comfortable with the WC measurement process for multiple reasons and reported difficulty with the measurement process. Our findings suggest that non-medical staff can reliably and validly measure WC within a typical outpatient mental health treatment setting, but discomfort with the procedure and difficulty with the measurement process may interfere with this practice as part of usual care. Adapted from the source document. JF - Community Mental Health Journal AU - Barber, Jessica AU - Palmese, Laura AU - Chwastiak, Lydia A AU - Ratliff, Joseph C AU - Reutenauer, Erin L AU - Jean-Baptiste, Michel AU - Tek, Cenk AD - Department of Psychology (116B), VA Connecticut Healthcare System, West Haven, 950 Campbell Avenue, West Haven, CT, 06516, USA Jessica.barber@va.gov Y1 - 2014/01// PY - 2014 DA - January 2014 SP - 68 EP - 74 PB - Springer, Dordrecht The Netherlands VL - 50 IS - 1 SN - 0010-3853, 0010-3853 KW - Outpatients KW - Measurement KW - Waist KW - Reliability KW - Community mental health services KW - Comfort KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558990325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Reliability+and+Practicality+of+Measuring+Waist+Circumference+to+Monitor+Cardiovascular+Risk+Among+Community+Mental+Health+Center+Patients&rft.au=Barber%2C+Jessica%3BPalmese%2C+Laura%3BChwastiak%2C+Lydia+A%3BRatliff%2C+Joseph+C%3BReutenauer%2C+Erin+L%3BJean-Baptiste%2C+Michel%3BTek%2C+Cenk&rft.aulast=Barber&rft.aufirst=Jessica&rft.date=2014-01-01&rft.volume=50&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-012-9590-2 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Number of references - 31 N1 - Last updated - 2016-09-27 N1 - CODEN - CMHJAY N1 - SubjectsTermNotLitGenreText - Reliability; Measurement; Community mental health services; Comfort; Outpatients; Waist DO - http://dx.doi.org/10.1007/s10597-012-9590-2 ER - TY - JOUR T1 - Association of stressful life events with incident falls and fractures in older men: the Osteoporotic Fractures in Men (MrOS) Study AN - 1520333347; 201409314 AB - Background: small, retrospective studies suggest that major life events and/or sudden emotional stress may increase fall and fracture risk. The current study examines these associations prospectively. Methods: a total of 5,152 men aged >=65 years in the Osteoporotic Fractures in Men study self-reported data on stressful life events for 1 year prior to study Visit 2. Incident falls and fractures were ascertained for 1 year after Visit 2. Fractures were centrally confirmed. Results: a total of 2,932 (56.9%) men reported >=1 type of stressful life event. In men with complete stressful life event, fall and covariate data (n = 3,949), any stressful life event was associated with a 33% increased risk of incident fall [relative risk (RR) 1.33, 95% confidence interval (CI) 1.19-1.49] and 68% increased risk of multiple falls (RR = 1.68, 95% CI = 1.40-2.01) in the year following Visit 2 after adjustment for age, education, Parkinson's disease, diabetes, stroke, instrumental activities of daily living (IADL) impairment, chair stand time, walk speed, multiple past falls, depressive symptoms and antidepressant use. Risk increased with the number of types of stressful life events. Though any stressful life event was associated with a 58% increased age-adjusted risk for incident fracture, this association was attenuated and no longer statistically significant after additional adjustment for total hip bone mineral density, fracture after age 50, Parkinson's disease, stroke and IADL impairment. Conclusions: in this cohort of older men, stressful life events significantly increased risk of incident falls independent of other explanatory variables, but did not independently increase incident fracture risk. Adapted from the source document. JF - Age and Ageing AU - Fink, Howard A AU - Kuskowski, Michael A AU - Marshall, Lynn M AD - VA Medical Center, Geriatric Research Education and Clinical Center, One Veterans Drive, 11-G, Minneapolis, MN 55417, USA howard.fink@va.gov Y1 - 2014/01// PY - 2014 DA - January 2014 SP - 103 EP - 108 PB - Oxford University Press, UK VL - 43 IS - 1 SN - 0002-0729, 0002-0729 KW - accidental falls fractures life change events psychological stress prospective studies aged male men older people KW - Older men KW - Falls KW - Men KW - Parkinson's disease KW - Fractures KW - Stressful events KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520333347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Age+and+Ageing&rft.atitle=Association+of+stressful+life+events+with+incident+falls+and+fractures+in+older+men%3A+the+Osteoporotic+Fractures+in+Men+%28MrOS%29+Study&rft.au=Fink%2C+Howard+A%3BKuskowski%2C+Michael+A%3BMarshall%2C+Lynn+M&rft.aulast=Fink&rft.aufirst=Howard&rft.date=2014-01-01&rft.volume=43&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Age+and+Ageing&rft.issn=00020729&rft_id=info:doi/10.1093%2Fageing%2Faft117 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Fractures; Stressful events; Falls; Men; Older men; Parkinson's disease DO - http://dx.doi.org/10.1093/ageing/aft117 ER - TY - JOUR T1 - Comparisons of Prisoners Who Make or Do Not Make Suicide Attempts and Further Who Make One or Multiple Attempts AN - 1520321772; 201411996 AB - Suicidal behavior among prisoners is a major problem. The objective of this study was to compare prisoners who have made an attempt at suicide vs non-attempters and further to compare single vs multiple suicide attempts. Among 1,537 prisoners, 200 (13%) had a lifetime history of attempting suicide and 92 (6%) had made multiple attempts. Those who had made multiple or single attempts were compared on socio-demographic, developmental, personality, forensic, and psychiatric variables. In a re-analysis we also compared non-attempters with attempters in this larger sample. The comparison showed that prisoners who had made multiple attempts had experienced significantly more childhood trauma, were more introverted, less resilient, had a history of self-mutilation, and had more suicidal ideation. Anger and hostility scores and criminal and violence histories significantly differentiated prisoners who had attempted from those who had never attempted but they did not differentiate multiple from single attempters. Having a history of multiple attempts may be indicative of more severe psychopathology in prisoners, as found in other populations. These findings may be helpful in predicting which prisoner is at increased risk of exhibiting suicidal behavior while incarcerated and after release. JF - Archives of Suicide Research AU - Roy, Alec AU - Carli, Vladimir AU - Sarchiapone, Marco AU - Branchey, Marc Y1 - 2014/01// PY - 2014 DA - January 2014 SP - 28 EP - 38 PB - Taylor & Francis, Philadelphia PA VL - 18 IS - 1 SN - 1381-1118, 1381-1118 KW - Suicidal behaviour KW - Hostility KW - Suicide KW - Psychopathology KW - Prisoners KW - Selfinjury KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520321772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Suicide+Research&rft.atitle=Comparisons+of+Prisoners+Who+Make+or+Do+Not+Make+Suicide+Attempts+and+Further+Who+Make+One+or+Multiple+Attempts&rft.au=Roy%2C+Alec%3BCarli%2C+Vladimir%3BSarchiapone%2C+Marco%3BBranchey%2C+Marc&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2014-01-01&rft.volume=18&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Archives+of+Suicide+Research&rft.issn=13811118&rft_id=info:doi/10.1080%2F13811118.2013.801816 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - ASREFQ N1 - SubjectsTermNotLitGenreText - Prisoners; Suicidal behaviour; Suicide; Hostility; Selfinjury; Psychopathology DO - http://dx.doi.org/10.1080/13811118.2013.801816 ER - TY - JOUR T1 - Fostering Self-Awareness in Novice Therapists Using Internal Family Systems Therapy AN - 1520319283; 201402565 AB - This qualitative study used a phenomenological approach to understand: (a) whether and how the Internal Family Systems (IFS) model helps beginning therapists gain awareness of their internal processes and (b) whether and how such awareness influences their clinical work. Semi-structured individual interviews were conducted with seven beginning therapists and data were analyzed using thematic coding. Findings suggest that IFS helped therapists identify, understand, and manage their internal processes, which seemed to benefit the therapeutic relationship, identify therapists' personal agendas, model work with the internal system, and foster a better understanding of the client's internal system. Clinical training implications are discussed. Adapted from the source document. JF - The American Journal of Family Therapy AU - Mojta, Carl AU - Falconier, Mariana K AU - Huebner, Angela J AD - U.S. Department of Veterans Affairs, Readjustment Counseling Services, DC Vet Center, Washington, District of Columbia, USA Y1 - 2014/01// PY - 2014 DA - January 2014 SP - 67 EP - 78 PB - Taylor & Francis, Philadelphia PA VL - 42 IS - 1 SN - 0192-6187, 0192-6187 KW - Client Relations KW - Consciousness KW - Therapists KW - Training KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520319283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Family+Therapy&rft.atitle=Fostering+Self-Awareness+in+Novice+Therapists+Using+Internal+Family+Systems+Therapy&rft.au=Mojta%2C+Carl%3BFalconier%2C+Mariana+K%3BHuebner%2C+Angela+J&rft.aulast=Mojta&rft.aufirst=Carl&rft.date=2014-01-01&rft.volume=42&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Family+Therapy&rft.issn=01926187&rft_id=info:doi/10.1080%2F01926187.2013.772870 LA - English DB - Social Services Abstracts N1 - Date revised - 2014-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJFTDE N1 - SubjectsTermNotLitGenreText - Therapists; Consciousness; Client Relations; Training DO - http://dx.doi.org/10.1080/01926187.2013.772870 ER - TY - JOUR T1 - Exposure to Low Levels of Jet-Propulsion Fuel Impairs Brainstem Encoding of Stimulus Intensity AN - 1512328618; 19388073 AB - Jet propulsion fuel-8 (JP-8) is a kerosene-based fuel that is used in military jets. The U.S. Armed Services and North Atlantic Treaty Organization countries adopted JP-8 as a standard fuel source and the U.S. military alone consumes more than 2.5 billion gallons annually. Preliminary epidemiologic data suggested that JP-8 may interact with noise to induce hearing loss, and animal studies revealed damage to presynaptic sensory cells in the cochlea. In the current study, Long-Evans rats were divided into four experimental groups: control, noise only, JP-8 only, and JP-8 + noise. A subototoxic level of JP-8 was used alone or in combination with a nondamaging level of noise. Functional and structural assays of the presynaptic sensory cells combined with neurophysiologic studies of the cochlear nerve revealed that peripheral auditory function was not affected by individual exposures and there was no effect when the exposures were combined. However, the central auditory nervous system exhibited impaired brainstem encoding of stimulus intensity. These findings may represent important and major shifts in the theoretical framework that governs current understanding of jet fuel and/or jet fuel + noise-induced ototoxicity. From an epidemiologic perspective, results indicate that jet fuel exposure may exert consequences on auditory function that may be more widespread and insidious than what was previously shown. It is possible that a large population of military personnel who are suffering from the effects of jet fuel exposure may be misidentified because they would exhibit normal hearing thresholds but harbor a "hidden" brainstem dysfunction. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Guthrie, O'neil W AU - Xu, Helen AU - Wong, Brian A AU - McInturf, Shawn M AU - Reboulet, Jim E AU - Ortiz, Pedro A AU - Mattie, David R AD - Research Service-151, Loma Linda Veterans Affairs Medical Center, Loma Linda, California, USA, O'neil.Guthrie@va.gov Y1 - 2014 PY - 2014 DA - 2014 SP - 261 EP - 280 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 77 IS - 5 SN - 1528-7394, 1528-7394 KW - CSA Neurosciences Abstracts; Pollution Abstracts; Environment Abstracts; Toxicology Abstracts KW - Cochlea KW - Data processing KW - Auditory system KW - Fuels KW - Ototoxicity KW - Brain stem KW - Noise levels KW - Hearing loss KW - AN, North Atlantic KW - Rats KW - USA KW - Nervous system KW - Structure-function relationships KW - Military KW - Military personnel KW - ENA 03:Energy KW - N3 11028:Neuropharmacology & toxicology KW - P 1000:MARINE POLLUTION KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1512328618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Exposure+to+Low+Levels+of+Jet-Propulsion+Fuel+Impairs+Brainstem+Encoding+of+Stimulus+Intensity&rft.au=Guthrie%2C+O%27neil+W%3BXu%2C+Helen%3BWong%2C+Brian+A%3BMcInturf%2C+Shawn+M%3BReboulet%2C+Jim+E%3BOrtiz%2C+Pedro+A%3BMattie%2C+David+R&rft.aulast=Guthrie&rft.aufirst=O%27neil&rft.date=2014-01-01&rft.volume=77&rft.issue=5&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2013.862892 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Cochlea; Nervous system; Data processing; Structure-function relationships; Auditory system; Ototoxicity; Fuels; Brain stem; Hearing loss; Military personnel; Rats; Noise levels; Military; USA; AN, North Atlantic DO - http://dx.doi.org/10.1080/15287394.2013.862892 ER - TY - JOUR T1 - Hydrosoluble vitamins. AN - 1490780438; 24365359 AB - The hydrosoluble vitamins are a group of organic substances that are required by humans in small amounts to prevent disorders of metabolism. Significant progress has been made in our understanding of the biochemical, physiologic and nutritional aspects of the water-soluble vitamins. Deficiency of these particular vitamins, most commonly due to inadequate nutrition, can result in disorders of the nervous system. Many of these disorders have been successfully prevented in developed countries; however, they are still common in developing countries. Of the hydrosoluble vitamins, the nervous system depends the most on vitamins B and C (ascorbic acid) for proper functioning. The B group vitamins include thiamin (vitamin B1), riboflavin (vitamin B2), niacin or niacinamide (vitamin B3), pantothenic acid (vitamin B5), pyridoxine or pyridoxal (vitamin B6) and cobalamin (vitamin B12). Clinical findings depend upon the deficiency of the underlying vitamin; generally, deficiency symptoms are seen from a combination rather than an isolated vitamin deficiency. True hereditary metabolic disorders and serious deficiency-associated diseases are rare and in general limited to particular geographic regions and high-risk groups. Their recognition is truly important as that determines the appropriate therapeutic management. The general availability of vitamins to practically everyone and several national health programs have saved many lives and prevented complications. However, there has been some apprehension for several decades about how harmless generous dosages of these vitamins are. Overt overdosages can cause vitamin toxicity affecting various body systems including the nervous system. Systemically, vitamin toxicity is associated with nonspecific symptoms, such as nausea, vomiting, diarrhea, and skin rash which are common with any acute or chronic vitamin overdose. At a national level, recommended daily allowances for vitamins become policy statements. Nutrition policy has far reaching implications in the food industry, in agriculture, and in food provision programs. Overall, water-soluble vitamins are complex molecular structures and even today, many areas of vitamin biochemistry still need to be explored. Many readers might be of the opinion that the classic forms of nutritional deficiency diseases have faded into the background of interesting history. This has caused their diverse symptoms to be neglected by most modern physicians since vitamin enrichment of many foods automatically erases them from their consideration in differential diagnosis. Vitamin B12 and folic acid deficiencies are discussed in other chapters. © 2014 Elsevier B.V. All rights reserved. JF - Handbook of clinical neurology AU - Chawla, Jasvinder AU - Kvarnberg, David AD - Department of Neurology, Hines VA Hospital, Hines, IL, USA; Department of Neurology, Loyola University Medical Center, Maywood, IL, USA. Electronic address: Jasvinder.chawla2@va.gov. ; Department of Neurology, Loyola University Medical Center, Maywood, IL, USA. Y1 - 2014 PY - 2014 DA - 2014 SP - 891 EP - 914 VL - 120 SN - 0072-9752, 0072-9752 KW - Vitamins KW - 0 KW - Index Medicus KW - beriberi pellagra KW - Wernicke’s encephalopathy KW - riboflavin KW - thiamin KW - niacin or niacinamide KW - Korsakoff psychosis KW - pyridoxine or pyridoxal KW - polyneuropathy KW - pantothenic acid KW - encephalopathy KW - Neuroimaging KW - Humans KW - Avitaminosis -- complications KW - Avitaminosis -- genetics KW - Avitaminosis -- pathology KW - Vitamins -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1490780438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Handbook+of+clinical+neurology&rft.atitle=Hydrosoluble+vitamins.&rft.au=Chawla%2C+Jasvinder%3BKvarnberg%2C+David&rft.aulast=Chawla&rft.aufirst=Jasvinder&rft.date=2014-01-01&rft.volume=120&rft.issue=&rft.spage=891&rft.isbn=&rft.btitle=&rft.title=Handbook+of+clinical+neurology&rft.issn=00729752&rft_id=info:doi/10.1016%2FB978-0-7020-4087-0.00059-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-04-22 N1 - Date created - 2013-12-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/B978-0-7020-4087-0.00059-0 ER - TY - JOUR T1 - Effect of Repeated Evaluation and Repeated Exposure on Acceptability Ratings of Sentences AN - 1667936618; 201502624 AB - This study investigated the effect of repeated evaluation and repeated exposure on grammatical acceptability ratings for both acceptable and unacceptable sentence types. In Experiment 1, subjects in the Experimental group rated multiple examples of two ungrammatical sentence types (ungrammatical binding and double object with dative-only verb), and two difficult to process sentence types [center-embedded (2) and garden path ambiguous relative], along with matched grammatical/non-difficult sentences, before rating a final set of experimental sentences. Subjects in the control group rated unrelated sentences during the exposure period before rating the experimental sentences. Subjects in the Experimental group rated both grammatical and ungrammatical sentences as more acceptable after repeated evaluation than subjects in the Control group. In Experiment 2, subjects answered a comprehension question after reading each sentence during the exposure period. Subjects in the experimental group rated garden path and center-embedded (1) sentences as higher in acceptability after comprehension exposure than subjects in the control group. The results are consistent with increased fluency of comprehension being misattributed as a change in acceptability. Adapted from the source document JF - Journal of Psycholinguistic Research AU - Zervakis, Jennifer AU - Mazuka, Reiko AD - Health Services Research and Development, Durham VA Medical Center (152), Department of Veteran Affairs, 508 Fulton St., Durham, NC, 27705, USA jennifer.zervakis@va.gov Y1 - 2013/12// PY - 2013 DA - December 2013 SP - 505 EP - 525 VL - 42 IS - 6 SN - 0090-6905, 0090-6905 KW - Psycholinguistics (69200) KW - Comprehension (13950) KW - Syntactic Processing (86760) KW - Acceptability (00085) KW - Sentences (77450) KW - Fluency (24910) KW - article KW - 4013: psycholinguistics; syntactic processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1667936618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psycholinguistic+Research&rft.atitle=Effect+of+Repeated+Evaluation+and+Repeated+Exposure+on+Acceptability+Ratings+of+Sentences&rft.au=Zervakis%2C+Jennifer%3BMazuka%2C+Reiko&rft.aulast=Zervakis&rft.aufirst=Jennifer&rft.date=2013-12-01&rft.volume=42&rft.issue=6&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psycholinguistic+Research&rft.issn=00906905&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2015-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JPLRB7 N1 - SubjectsTermNotLitGenreText - Sentences (77450); Acceptability (00085); Psycholinguistics (69200); Comprehension (13950); Syntactic Processing (86760); Fluency (24910) ER - TY - JOUR T1 - A comparison of NAL and DSL prescriptive methods for paediatric hearing-aid fitting: Predicted speech intelligibility and loudness AN - 1558998850; 201413376 AB - Objective: To examine the impact of prescription on predicted speech intelligibility and loudness for children. Design: A between-group comparison of speech intelligibility index (SII) and loudness, based on hearing aids fitted according to NALNL1, DSL v4.1, or DSL m[i/o] prescriptions. A within-group comparison of gains prescribed by DSL m[i/o] and NAL-NL2 for children in terms of SII and loudness. Study sample: Participants were 200 children, who were randomly assigned to first hearing-aid fitting with either NAL-NL1, DSL v4.1, or DSL m[i/o]. Audiometric data and hearing-aid data at 3 years of age were used. Results: On average, SII calculated on the basis of hearing-aid gains were higher for DSL than for NAL-NL1 at low input level, equivalent at medium input level, and higher for NAL-NL1 than DSL at high input level. Greater loudness was associated with DSL than with NAL-NL1, across a range of input levels. Comparing NAL-NL2 and DSL m[i/o] target gains revealed higher SII for the latter at low input level. SII was higher for NAL-NL2 than for DSL m[i/o] at medium- and high-input levels despite greater loudness for gains prescribed by DSL m[i/o] than by NAL-NL2. Conclusion: The choice of prescription has minimal effects on speech intelligibility predictions but marked effects on loudness predictions. Adapted from the source document JF - International Journal of Audiology AU - Ching, Teresa YC AU - Johnson, Earl E AU - Hou, Sanna AU - Dillon, Harvey AU - Zhang, Vicky AU - Burns, Lauren AU - van Buynder, Patricia AU - Wong, Angela AU - Flynn, Christopher AD - National Acoustic Laboratories of Australia, Chatswood, Sydney, New South Wales, Australia; The HEARing CRC, Sydney, New South Wales, Australia; Mountain Home VA Medical Center, PO Box 4000, Audiology-126, Mountain Home, TN 37684, USA earl.johnson@va.gov Y1 - 2013/12// PY - 2013 DA - December 2013 SP - S29 EP - S38 VL - 52 IS - S2 SN - 1499-2027, 1499-2027 KW - Speech Perception (82700) KW - Intelligibility (36600) KW - Intensity (Acoustics) (36650) KW - Hearing Disorders (31450) KW - Hearing Aids (31250) KW - Children (11850) KW - article KW - 6310: hearing-pathological and normal; hearing-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558998850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=A+comparison+of+NAL+and+DSL+prescriptive+methods+for+paediatric+hearing-aid+fitting%3A+Predicted+speech+intelligibility+and+loudness&rft.au=Ching%2C+Teresa+YC%3BJohnson%2C+Earl+E%3BHou%2C+Sanna%3BDillon%2C+Harvey%3BZhang%2C+Vicky%3BBurns%2C+Lauren%3Bvan+Buynder%2C+Patricia%3BWong%2C+Angela%3BFlynn%2C+Christopher&rft.aulast=Ching&rft.aufirst=Teresa&rft.date=2013-12-01&rft.volume=52&rft.issue=S2&rft.spage=S29&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2014-09-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hearing Disorders (31450); Hearing Aids (31250); Children (11850); Intensity (Acoustics) (36650); Intelligibility (36600); Speech Perception (82700) ER - TY - JOUR T1 - Hearing-aid safety: A comparison of estimated threshold shifts for gains recommended by NAL-NL2 and DSL m[i/o] prescriptions for children AN - 1558998391; 201413374 AB - Objective: To investigate the predicted threshold shift associated with the use of nonlinear hearing aids fitted to the NAL-NL2 or the DSL m[i/o] prescription for children with the same audiograms. For medium and high input levels, we asked: (1) How does predicted asymptotic threshold shifts (ATS) differ according to the choice of prescription? (2) How does predicted ATS vary with hearing level for gains prescribed by the two prescriptions? Design: A mathematical model consisting of the modified power law combined with equations for predicting temporary threshold shift (Macrae, 1994b) was used to predict ATS. Study sample: Predicted threshold shift were determined for 57 audiograms at medium and high input levels. Results: For the 57 audiograms, DSL m[i/o] gains for high input levels were associated with increased risk relative to NAL-NL2. The variation of ATS with hearing level suggests that NAL-NL2 gains became unsafe when hearing loss > 90 dB HL. The gains prescribed by DSL m[i/o] became unsafe when hearing loss > 80 dB HL at a medium input level, and > 70 dB HL at a high input level. Conclusion: There is a risk of damage to hearing for children using nonlinear amplification. Vigilant checking for threshold shift is recommended. Adapted from the source document JF - International Journal of Audiology AU - Ching, Teresa Y C AU - Johnson, Earl E AU - Seeto, Mark AU - Macrae, John H AD - National Acoustic Laboratories of Australia, Sydney, Australia; The HEARing CRC, Melbourne, Australia Earl.Johnson@va.gov Y1 - 2013/12// PY - 2013 DA - December 2013 SP - S39 EP - S45 VL - 52 IS - S2 SN - 1499-2027, 1499-2027 KW - Hearing Aids (31250) KW - Children (11850) KW - article KW - 6310: hearing-pathological and normal; hearing-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558998391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=Hearing-aid+safety%3A+A+comparison+of+estimated+threshold+shifts+for+gains+recommended+by+NAL-NL2+and+DSL+m%5Bi%2Fo%5D+prescriptions+for+children&rft.au=Ching%2C+Teresa+Y+C%3BJohnson%2C+Earl+E%3BSeeto%2C+Mark%3BMacrae%2C+John+H&rft.aulast=Ching&rft.aufirst=Teresa+Y&rft.date=2013-12-01&rft.volume=52&rft.issue=S2&rft.spage=S39&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2014-09-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hearing Aids (31250); Children (11850) ER - TY - JOUR T1 - Posttraumatic Stress Disorder and Its Comorbidities Among American Indian Veterans AN - 1558997828; 201432560 AB - Goal consists of describing the demographic and comorbid characteristics associated with Posttraumatic Stress Disorder (PTSD) among American Indian veterans with any lifetime Axis 1 disorder. Sample included 252 American Indian veterans, obtained from a community sample of 557, using targeted sampling designed to provide a representative sample, structured to include equal numbers of rural and urban veterans and a twofold over sample of women. Data collection involved lifetime diagnoses based on the Diagnostic Interview Schedule/Quick Version/DSM-III-R, demographic characteristics, and combat exposure. Findings Bivariate comparisons showed positive relationships of PTSD with combat exposure, mood disorder and anxiety disorders (excluding PTSD), but a negative relationship with substance use disorder. Binary logistic regression analyses showed an independent association of PTSD with mood and anxiety disorders as well as combat exposure. Adapted from the source document. JF - Community Mental Health Journal AU - Westermeyer, Joseph AU - Canive, Jose AD - Minneapolis VAMC, Department of Psychiatry and Anthropology, University of Minnesota, Minneapolis, MN, USA joseph.westermeyer@med.va.gov Y1 - 2013/12// PY - 2013 DA - December 2013 SP - 704 EP - 708 PB - Springer, Dordrecht The Netherlands VL - 49 IS - 6 SN - 0010-3853, 0010-3853 KW - American Indian people KW - Veterans KW - Posttraumatic stress disorder KW - Affective disorders KW - Demographic aspects KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558997828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Posttraumatic+Stress+Disorder+and+Its+Comorbidities+Among+American+Indian+Veterans&rft.au=Westermeyer%2C+Joseph%3BCanive%2C+Jose&rft.aulast=Westermeyer&rft.aufirst=Joseph&rft.date=2013-12-01&rft.volume=49&rft.issue=6&rft.spage=704&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-012-9565-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Number of references - 26 N1 - Last updated - 2016-09-27 N1 - CODEN - CMHJAY N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Veterans; American Indian people; Comorbidity; Demographic aspects; Affective disorders DO - http://dx.doi.org/10.1007/s10597-012-9565-3 ER - TY - JOUR T1 - Care management practices for chronic pain in veterans prescribed high doses of opioid medications AN - 1496666426; 201401093 AB - Background. There is growing interest in the primary care management of patients with chronic non-cancer pain (CNCP) who are prescribed long-term opioid therapy. Objective. The aim of this study was to examine the care management practices and medical utilization of patients prescribed high doses of opioids relative to patients prescribed traditional doses of opioids. Methods. We conducted a retrospective cohort study of veterans who had CNCP in 2008 and reviewed medical care for the prior 2 years. Patients with CNCP who were prescribed high-dose opioid therapy (>=180mg morphine equivalent per day for 90+ consecutive days; n = 60) were compared with patients prescribed traditional dose opioid therapy (5-179mg morphine equivalent per day for 90+ consecutive days; n = 60). Results. Patients in the high-dose group had several aspects of documented care that differed from patients in the traditional dose group, including more medical visits, attempting an opioid taper, receiving a urine drug screen and developing a pain goal. The majority of variables that were assessed did not differ between groups, including documented assessments of functional status or co-morbid psychopathology, opioid rotation, discussion of treatment side effects, non-pharmacological treatments or collaboration with mental health or pain specialists. Conclusions. Further work is needed to identify mechanisms for optimizing care management for patients with CNCP who are prescribed high doses of opioid medications. Adapted from the source document. JF - Family Practice AU - Morasco, Benjamin J AU - Cavanagh, Renee AU - Gritzner, Susan AU - Dobscha, Steven K AD - Mental Health and Clinical Neurosciences Division and benjamin.morasco@va.gov Y1 - 2013/12// PY - 2013 DA - December 2013 SP - 671 EP - 678 PB - Oxford University Press VL - 30 IS - 6 SN - 0263-2136, 0263-2136 KW - Chronic pain clinical treatment guidelines high-dose opioids opioids primary care KW - Veterans KW - Care management KW - Chronic pain KW - Dosage KW - Prescribed KW - Opioids KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1496666426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Family+Practice&rft.atitle=Care+management+practices+for+chronic+pain+in+veterans+prescribed+high+doses+of+opioid+medications&rft.au=Morasco%2C+Benjamin+J%3BCavanagh%2C+Renee%3BGritzner%2C+Susan%3BDobscha%2C+Steven+K&rft.aulast=Morasco&rft.aufirst=Benjamin&rft.date=2013-12-01&rft.volume=30&rft.issue=6&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Family+Practice&rft.issn=02632136&rft_id=info:doi/10.1093%2Ffampra%2Fcmt038 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-01-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Opioids; Prescribed; Dosage; Chronic pain; Care management; Veterans DO - http://dx.doi.org/10.1093/fampra/cmt038 ER - TY - JOUR T1 - Personalized Psychotherapy: A Treatment Approach Based on Theodore Millon's Integrated Model of Clinical Science AN - 1496663607; 201401471 AB - In this article we present personalized psychotherapy, a treatment approach for people with a wide range of personality problems and clinical syndromes that is a central part of Theodore Millon's unified clinical science model of personality and psychopathology. Because the intervention strategy is fully integrated with an evolutionary perspective on human development, we offer it in this context. We begin with a historical overview of Millon's model and its relationship to the Diagnostic and Statistical Manual of Mental Disorders (DSM). We then present his basic theoretical principles and personality taxonomy, and discuss variations in personality functioning across the normal-abnormal continuum. We move on to describe assessment measures that were developed to operationalize his concepts and ideas, and which are used as the basis for creating treatment plans. The premises and principles of personalized psychotherapy are described to show how the intervention model is squarely focused on the integrated unity of the person. We look at presenting problems of all kinds from the point of view of how they emanate from, and are related to, the individual's unique combination of temperament, traits, preferences, behavioral patterns, and coping strategies. We then specify multimodal interventions (e.g., a combination of pharmacologic, cognitive, behavioral, phenomenological, interpersonal, and/or intrapsychic treatments) and apply them in a particular sequence to maximize their impact, not only on the target symptoms, but on the underlying personality elements believed to be their primary cause. Adapted from the source document. JF - Journal of Personality AU - Strack, Stephen AU - Millon, Theodore AD - U.S. Department of Veterans Affairs Y1 - 2013/12// PY - 2013 DA - December 2013 SP - 528 EP - 541 PB - Blackwell Publishers, Malden MA VL - 81 IS - 6 SN - 0022-3506, 0022-3506 KW - Coping strategies KW - Psychotherapy KW - Personality KW - Personality problems KW - Treatment methods KW - Individualized KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1496663607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality&rft.atitle=Personalized+Psychotherapy%3A+A+Treatment+Approach+Based+on+Theodore+Millon%27s+Integrated+Model+of+Clinical+Science&rft.au=Strack%2C+Stephen%3BMillon%2C+Theodore&rft.aulast=Strack&rft.aufirst=Stephen&rft.date=2013-12-01&rft.volume=81&rft.issue=6&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality&rft.issn=00223506&rft_id=info:doi/10.1111%2Fjopy.12013 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-01-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JOPEAE N1 - SubjectsTermNotLitGenreText - Personality; Individualized; Psychotherapy; Treatment methods; Personality problems; Coping strategies DO - http://dx.doi.org/10.1111/jopy.12013 ER - TY - JOUR T1 - NEW PERSPECTIVES ON COMMUNITY-LEVEL DETERMINANTS OF HOMELESSNESS AN - 1494751220; 201404600 AB - Understanding the root causes of homelessness is important for developing effective solutions to the problem. This fact has not gone unnoticed by researchers, who have made numerous attempts to identify the underlying structural determinants of homelessness by modeling inter-community variation in the rate of homelessness as a function of community-level variables. Yet, prior studies in this area have a number of serious limitations, principally their reliance on methodologically flawed estimates of the size of the homeless population. The present study addresses this and other limitations by using newly available and more reliable estimates from the U.S. Department of Housing and Urban Development to model variation in the rate of homelessness across a large and diverse sample of communities throughout the United States. In doing so, this study builds on the analysis conducted by Lee, Price-Spratlen, and Kanan, and its findings have implications for policy and future research. Adapted from the source document. JF - Journal of Urban Affairs AU - Byrne, Thomas AU - Munley, Ellen A AU - Fargo, Jamison D AU - Montgomery, Ann E AU - Culhane, Dennis P AD - U.S. Department of Veterans Affairs, National Center on Homelessness Among Veterans. University of Pennsylvania Y1 - 2013/12// PY - 2013 DA - December 2013 SP - 607 EP - 625 PB - Blackwell Publishers, Malden MA VL - 35 IS - 5 SN - 0735-2166, 0735-2166 KW - Housing KW - Urban Development KW - United States of America KW - Homelessness KW - article KW - 2317: community/regional development; sociology of communities & regions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1494751220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Urban+Affairs&rft.atitle=NEW+PERSPECTIVES+ON+COMMUNITY-LEVEL+DETERMINANTS+OF+HOMELESSNESS&rft.au=Byrne%2C+Thomas%3BMunley%2C+Ellen+A%3BFargo%2C+Jamison+D%3BMontgomery%2C+Ann+E%3BCulhane%2C+Dennis+P&rft.aulast=Byrne&rft.aufirst=Thomas&rft.date=2013-12-01&rft.volume=35&rft.issue=5&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Journal+of+Urban+Affairs&rft.issn=07352166&rft_id=info:doi/10.1111%2Fj.1467-9906.2012.00643.x LA - English DB - Sociological Abstracts N1 - Date revised - 2014-02-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JUAFEM N1 - SubjectsTermNotLitGenreText - Homelessness; United States of America; Urban Development; Housing DO - http://dx.doi.org/10.1111/j.1467-9906.2012.00643.x ER - TY - JOUR T1 - Can Inhibitor-Resistant Substitutions in the Mycobacterium tuberculosis beta -Lactamase BlaC Lead to Clavulanate Resistance?: a Biochemical Rationale for the Use of beta -Lactam- beta -Lactamase Inhibitor Combinations AN - 1464505807; 18808478 AB - The current emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis calls for novel treatment strategies. Recently, BlaC, the principal beta -lactamase of Mycobacterium tuberculosis, was recognized as a potential therapeutic target. The combination of meropenem and clavulanic acid, which inhibits BlaC, was found to be effective against even extensively drug-resistant M. tuberculosis strains when tested in vitro. Yet there is significant concern that drug resistance against this combination will also emerge. To investigate the potential of BlaC to evolve variants resistant to clavulanic acid, we introduced substitutions at important amino acid residues of M. tuberculosis BlaC (R220, A244, S130, and T237). Whereas the substitutions clearly led to in vitro clavulanic acid resistance in enzymatic assays but at the expense of catalytic activity, transformation of variant BlaCs into an M. tuberculosis H37Rv background revealed that impaired inhibition of BlaC did not affect inhibition of growth in the presence of ampicillin and clavulanate. From these data we propose that resistance to beta -lactam- beta -lactamase inhibitor combinations will likely not arise from structural alteration of BlaC, therefore establishing confidence that this therapeutic modality can be part of a successful treatment regimen against M. tuberculosis. JF - Antimicrobial Agents & Chemotherapy AU - Kurz, Sebastian G AU - Wolff, Kerstin A AU - Hazra, Saugata AU - Bethel, Christopher R AU - Hujer, Andrea M AU - Smith, Kerri M AU - Xu, Yan AU - Tremblay, Lee W AU - Blanchard, John S AU - Nguyen, Liem AD - Case Western Reserve University School of Medicine, Cleveland, Ohio, USA, Robert.Bonomo@va.gov. Y1 - 2013/12// PY - 2013 DA - Dec 2013 SP - 6085 EP - 6096 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 57 IS - 12 SN - 0066-4804, 0066-4804 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Amino acid substitution KW - Tuberculosis KW - Mycobacterium tuberculosis KW - A 01340:Antibiotics & Antimicrobials KW - X 24310:Pharmaceuticals KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1464505807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Can+Inhibitor-Resistant+Substitutions+in+the+Mycobacterium+tuberculosis+beta+-Lactamase+BlaC+Lead+to+Clavulanate+Resistance%3F%3A+a+Biochemical+Rationale+for+the+Use+of+beta+-Lactam-+beta+-Lactamase+Inhibitor+Combinations&rft.au=Kurz%2C+Sebastian+G%3BWolff%2C+Kerstin+A%3BHazra%2C+Saugata%3BBethel%2C+Christopher+R%3BHujer%2C+Andrea+M%3BSmith%2C+Kerri+M%3BXu%2C+Yan%3BTremblay%2C+Lee+W%3BBlanchard%2C+John+S%3BNguyen%2C+Liem&rft.aulast=Kurz&rft.aufirst=Sebastian&rft.date=2013-12-01&rft.volume=57&rft.issue=12&rft.spage=6085&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01253-13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-11-01 N1 - Number of references - 1 N1 - Last updated - 2014-04-03 N1 - SubjectsTermNotLitGenreText - Tuberculosis; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/AAC.01253-13 ER - TY - JOUR T1 - Temporal trends in new exposure to antiepileptic drug monotherapy and suicide-related behavior AN - 1547864287; 20295084 AB - Objective: Because some recent studies suggest increased risk for suicide-related behavior (SRB; ideation, attempts) among those receiving antiepileptic drugs (AEDs), we examined the temporal relationship between new AED exposure and SRB in a cohort of older veterans. Methods: We used national Veterans Health Administration databases to identify veterans aged > or =65 years who received a new AED prescription in 2004-2006. All instances of SRB were identified using ICD-9-CM codes 1 year before and after the AED exposure (index) date. We also identified comorbid conditions and medication associated with SRB in prior research. We used generalized estimating equations with a logit link to examine the association between new AED exposure and SRB during 30-day intervals during the year before and after the index date, controlling for potential confounders. Results: In this cohort of 90,263 older veterans, the likelihood of SRB the month prior to AED exposure was significantly higher than in other time periods even after adjusting for potential confounders. Although there were 87 SRB events (74 individuals) the year before and 106 SRB events (92 individuals) after, approximately 22% (n = 16) of those also had SRB before the index date. Moreover, the rate of SRB after AED start was gradually reduced over time. Conclusions: The temporal pattern of AED exposure and SRB suggests that, in clinical practice, the peak in SRB is prior to exposure. While speculative, the rate of gradual reduction in SRB thereafter suggests that symptoms may prompt AED prescription. JF - Neurology AU - Pugh, Mary Jo V AU - Hesdorffer, Dale AU - Wang, Chen-Pin AU - Amuan, Megan E AU - Tabares, Jeffrey V AU - Finley, Erin P AU - Cramer, Joyce A AU - Kanner, Andres M AU - Bryan, Craig J Y1 - 2013/11/26/ PY - 2013 DA - 2013 Nov 26 SP - 1900 EP - 1906 PB - Lippincott Williams & Wilkins, 16522 Hunters Green Parkway Hagerstown MD 21740-2116 United States VL - 81 IS - 22 SN - 0028-3878, 0028-3878 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Databases KW - Mathematical models KW - Antiepileptic agents KW - X 24310:Pharmaceuticals KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1547864287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Temporal+trends+in+new+exposure+to+antiepileptic+drug+monotherapy+and+suicide-related+behavior&rft.au=Pugh%2C+Mary+Jo+V%3BHesdorffer%2C+Dale%3BWang%2C+Chen-Pin%3BAmuan%2C+Megan+E%3BTabares%2C+Jeffrey+V%3BFinley%2C+Erin+P%3BCramer%2C+Joyce+A%3BKanner%2C+Andres+M%3BBryan%2C+Craig+J&rft.aulast=Pugh&rft.aufirst=Mary+Jo&rft.date=2013-11-26&rft.volume=81&rft.issue=22&rft.spage=1900&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/10.1212%2F01.wnl.0000436614.51081.2e LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Last updated - 2014-11-12 N1 - SubjectsTermNotLitGenreText - Databases; Mathematical models; Antiepileptic agents DO - http://dx.doi.org/10.1212/01.wnl.0000436614.51081.2e ER - TY - JOUR T1 - Melanoma Epidemic: An Analysis of Six Decades of Data From the Connecticut Tumor Registry AN - 1622600760; 20351380 AB - PurposeMelanoma is the most commonly fatal form of skin cancer, with nearly 50,000 annual deaths worldwide. We sought to assess long-term trends in the incidence and mortality of melanoma in a state with complete and consistent registration.MethodsWe used data from the Connecticut Tumor Registry, the original National Cancer Institute SEER site, to determine trends in invasive melanoma (1950-2007), in situ melanoma (1973-2007), tumor thickness (1993-2007), mortality (1950-2007), and mortality to incidence (1950-2007) among the 19,973 and 3,635 Connecticut residents diagnosed with invasive melanoma (1950-2007) and who died as a result of melanoma (1950-2007), respectively. Main outcome measures included trends in incidence and mortality by age, sex, and birth cohort.ResultsIn the initial period (1950-1954), a diagnosis of invasive melanoma was rare, with 1.9 patient cases per 100,000 for men and 2.6 patient cases per 100,000 for women. Between 1950 and 2007, overall incidence rates rose more than 17-fold in men (1.9 to 33.5 per 100,000) and more than nine-fold in women (2.6 to 25.3 per 100,000). During these six decades, mortality rates more than tripled in men (1.6 to 4.9 per 100,000) and doubled in women (1.3 to 2.6 per 100,000). Mortality rates were generally stable or decreasing in men and women through age 54 years.ConclusionUnremitting increases in incidence and mortality of melanoma call for a nationally coordinated effort to encourage and promote innovative prevention and early-detection efforts. JF - Journal of Clinical Oncology AU - Geller, Alan C AU - Clapp, Richard W AU - Sober, Arthur J AU - Gonsalves, Lou AU - Mueller, Lloyd AU - Christiansen, Cindy L AU - Shaikh, Waqas AU - Miller, Donald R AD - Alan C. Geller, Harvard School of Public Health; Richard W. Clapp, Cindy L. Christiansen, and Donald R. Miller, Boston University School of Public Health; Arthur J. Sober, Massachusetts General Hospital; Donald R. Miller, Boston University School of Medicine, Boston; Cindy L. Christiansen and Donald R. Miller, Veterans Administration Center for Health Quality, Outcomes, and Economic Research, Bedford, MA; Lou Gonsalves and Lloyd Mueller, Connecticut Tumor Registry, Hartford, CT; and Waqas Shaikh, SUNY Downstate Medical Center, New York, NY, ageller@hsph.harvard.edu Y1 - 2013/11/20/ PY - 2013 DA - 2013 Nov 20 SP - 4172 EP - 4178 PB - American Society of Clinical Oncology VL - 31 IS - 33 SN - 0732-183X, 0732-183X KW - Health & Safety Science Abstracts KW - Mortality KW - Age KW - Prevention KW - Skin KW - USA, Connecticut KW - Tumors KW - Melanoma KW - Innovations KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622600760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Oncology&rft.atitle=Melanoma+Epidemic%3A+An+Analysis+of+Six+Decades+of+Data+From+the+Connecticut+Tumor+Registry&rft.au=Geller%2C+Alan+C%3BClapp%2C+Richard+W%3BSober%2C+Arthur+J%3BGonsalves%2C+Lou%3BMueller%2C+Lloyd%3BChristiansen%2C+Cindy+L%3BShaikh%2C+Waqas%3BMiller%2C+Donald+R&rft.aulast=Geller&rft.aufirst=Alan&rft.date=2013-11-20&rft.volume=31&rft.issue=33&rft.spage=4172&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/10.1200%2FJCO.2012.47.3728 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2014-11-26 N1 - SubjectsTermNotLitGenreText - Mortality; Prevention; Age; Skin; Tumors; Innovations; Melanoma; USA, Connecticut DO - http://dx.doi.org/10.1200/JCO.2012.47.3728 ER - TY - CPAPER T1 - Does the addition of phone calls to a FIT mailing program lead to higher colorectal cancer screening rates? T2 - 141st American Public Health Association Annual Meeting and Exposition AN - 1433510530; 6231591 JF - 141st American Public Health Association Annual Meeting and Exposition AU - Charlton, Mary AU - Mengeling, Michelle AU - Makki, Nader AU - Halfdanarson, Thor AU - Malhotra, Ashish AU - Klutts, J AU - Levy, Barcey AU - Kaboli, Peter Y1 - 2013/11/02/ PY - 2013 DA - 2013 Nov 02 KW - Screening KW - Colorectal cancer KW - Colorectal carcinoma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1433510530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=141st+American+Public+Health+Association+Annual+Meeting+and+Exposition&rft.atitle=Does+the+addition+of+phone+calls+to+a+FIT+mailing+program+lead+to+higher+colorectal+cancer+screening+rates%3F&rft.au=Charlton%2C+Mary%3BMengeling%2C+Michelle%3BMakki%2C+Nader%3BHalfdanarson%2C+Thor%3BMalhotra%2C+Ashish%3BKlutts%2C+J%3BLevy%2C+Barcey%3BKaboli%2C+Peter&rft.aulast=Charlton&rft.aufirst=Mary&rft.date=2013-11-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=141st+American+Public+Health+Association+Annual+Meeting+and+Exposition&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/141am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-08-31 N1 - Last updated - 2013-09-19 ER - TY - CPAPER T1 - Review of research and programs to prevent suicide among veterans T2 - 141st American Public Health Association Annual Meeting and Exposition AN - 1433510402; 6234765 JF - 141st American Public Health Association Annual Meeting and Exposition AU - Kemp, Janet Y1 - 2013/11/02/ PY - 2013 DA - 2013 Nov 02 KW - Reviews KW - Suicide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1433510402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=141st+American+Public+Health+Association+Annual+Meeting+and+Exposition&rft.atitle=Review+of+research+and+programs+to+prevent+suicide+among+veterans&rft.au=Kemp%2C+Janet&rft.aulast=Kemp&rft.aufirst=Janet&rft.date=2013-11-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=141st+American+Public+Health+Association+Annual+Meeting+and+Exposition&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/141am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-08-31 N1 - Last updated - 2013-09-19 ER - TY - CPAPER T1 - Updated typology of homeless veterans T2 - 141st American Public Health Association Annual Meeting and Exposition AN - 1433510103; 6235011 JF - 141st American Public Health Association Annual Meeting and Exposition AU - Casey, Roger AU - Schinka, John AU - Kasprow, Wesley Y1 - 2013/11/02/ PY - 2013 DA - 2013 Nov 02 KW - Typology KW - Homelessness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1433510103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=141st+American+Public+Health+Association+Annual+Meeting+and+Exposition&rft.atitle=Updated+typology+of+homeless+veterans&rft.au=Casey%2C+Roger%3BSchinka%2C+John%3BKasprow%2C+Wesley&rft.aulast=Casey&rft.aufirst=Roger&rft.date=2013-11-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=141st+American+Public+Health+Association+Annual+Meeting+and+Exposition&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/141am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-08-31 N1 - Last updated - 2013-09-19 ER - TY - CPAPER T1 - An overview of suicide among veterans and evaluation of existing programs T2 - 141st American Public Health Association Annual Meeting and Exposition AN - 1433510032; 6234764 JF - 141st American Public Health Association Annual Meeting and Exposition AU - Bossarte, Robert Y1 - 2013/11/02/ PY - 2013 DA - 2013 Nov 02 KW - Reviews KW - Suicide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1433510032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=141st+American+Public+Health+Association+Annual+Meeting+and+Exposition&rft.atitle=An+overview+of+suicide+among+veterans+and+evaluation+of+existing+programs&rft.au=Bossarte%2C+Robert&rft.aulast=Bossarte&rft.aufirst=Robert&rft.date=2013-11-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=141st+American+Public+Health+Association+Annual+Meeting+and+Exposition&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/141am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-08-31 N1 - Last updated - 2013-09-19 ER - TY - CPAPER T1 - Relationship between adverse childhood experiences and adult homelessness: A secondary analysis of behavioral risk factor surveillance system data T2 - 141st American Public Health Association Annual Meeting and Exposition AN - 1433509567; 6232964 JF - 141st American Public Health Association Annual Meeting and Exposition AU - Montgomery, Ann AU - Cutuli, J AU - Evans-Chase, Michelle AU - Treglia, Dan AU - Culhane, Dennis Y1 - 2013/11/02/ PY - 2013 DA - 2013 Nov 02 KW - Biological surveys KW - Data processing KW - Secondary analysis KW - Risk factors KW - Children KW - Homelessness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1433509567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=141st+American+Public+Health+Association+Annual+Meeting+and+Exposition&rft.atitle=Relationship+between+adverse+childhood+experiences+and+adult+homelessness%3A+A+secondary+analysis+of+behavioral+risk+factor+surveillance+system+data&rft.au=Montgomery%2C+Ann%3BCutuli%2C+J%3BEvans-Chase%2C+Michelle%3BTreglia%2C+Dan%3BCulhane%2C+Dennis&rft.aulast=Montgomery&rft.aufirst=Ann&rft.date=2013-11-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=141st+American+Public+Health+Association+Annual+Meeting+and+Exposition&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/141am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-08-31 N1 - Last updated - 2013-09-19 ER - TY - CPAPER T1 - Military sexual trauma monologues T2 - 141st American Public Health Association Annual Meeting and Exposition AN - 1433509506; 6233173 JF - 141st American Public Health Association Annual Meeting and Exposition AU - Hall, Marcia Y1 - 2013/11/02/ PY - 2013 DA - 2013 Nov 02 KW - Military KW - Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1433509506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=141st+American+Public+Health+Association+Annual+Meeting+and+Exposition&rft.atitle=Military+sexual+trauma+monologues&rft.au=Hall%2C+Marcia&rft.aulast=Hall&rft.aufirst=Marcia&rft.date=2013-11-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=141st+American+Public+Health+Association+Annual+Meeting+and+Exposition&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/141am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-08-31 N1 - Last updated - 2013-09-19 ER - TY - JOUR T1 - The impact of perceived sleep quality and sleep efficiency/duration on cannabis use during a self-guided quit attempt AN - 1837316729; 18687841 AB - Poor sleep quality may play a significant role in observed high rates of sustained cannabis use among veterans attempting to quit. We investigated whether individuals with poorer perceived sleep quality (rather than sleep efficiency/duration), as measured via the Pittsburgh Sleep Quality Index (Buysse, Reynolds, Monk, & Berman, 1989), would have less of a reduction in cannabis use (measured via Timeline FollowBack; Sobell and Sobell, 1992) during the first 6 months following a self-guided quit attempt. We expected these effects to remain significant after adjusting for baseline age, posttraumatic stress symptoms, as well as alcohol, tobacco, and opioid use, and cannabis withdrawal severity over the course of 6 months following the cannabis cessation attempt. Generalized linear mixed modeling using a Poisson distribution was employed to test the hypotheses among 102 cannabis dependent, primarily male, military veterans. Results indicated that veterans with poor perceived sleep quality had less of a reduction in mean cannabis use following a self-guided cannabis cessation attempt compared to those with good perceived sleep quality, while efficiency/duration was unrelated to cannabis use outcomes. Conclusions from this study should be considered in light of limitations including the use of self-report measures and generalizability to non-veterans and women. JF - Addictive Behaviors AU - Babson, KA AU - Boden, M T AU - Bonn-Miller, MO AD - 795 Willow Road (152-MPD), Menlo Park, CA 94025, United States, Kimberly.Babson@va.gov Y1 - 2013/11// PY - 2013 DA - November 2013 SP - 2707 EP - 2713 VL - 38 IS - 11 SN - 0306-4603, 0306-4603 KW - Toxicology Abstracts KW - Age KW - Sleep KW - Withdrawal KW - Cannabis KW - alcohols KW - Tobacco KW - Opioids KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837316729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+Behaviors&rft.atitle=The+impact+of+perceived+sleep+quality+and+sleep+efficiency%2Fduration+on+cannabis+use+during+a+self-guided+quit+attempt&rft.au=Babson%2C+KA%3BBoden%2C+M+T%3BBonn-Miller%2C+MO&rft.aulast=Babson&rft.aufirst=KA&rft.date=2013-11-01&rft.volume=38&rft.issue=11&rft.spage=2707&rft.isbn=&rft.btitle=&rft.title=Addictive+Behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Age; Withdrawal; Sleep; Tobacco; alcohols; Cannabis; Opioids ER - TY - JOUR T1 - Processes and Outcomes of the Veterans Health Administration Safe Patient Handling Program: Study Protocol AN - 1735638814; 201509480 AB - The goal of the present study is to evaluate the effects associated with the national implementation of a comprehensive safe patient handling (SPH) program. The primary objectives of the research were to determine the effectiveness of the SPH program in improving direct care nursing outcomes and to provide a context for understanding variations in program results across sites over time. Secondary objectives of the present research were to evaluate the effectiveness of the program in reducing direct and indirect costs associated with patient handling, to explore the potential mediating and moderating mechanisms, and to identify unintended consequences of implementing the program. To our knowledge, this is the largest evaluation of an SPH program in the United States. Implementation of the VA-wide SPH program afforded the opportunity for rigorous evaluation in a naturalistic context. Findings will guide VA operations for policy and decision making about resources, and will be useful for health care, in general, outside of the VA, in implementation and impact of an SPH program. Adapted from the source document. JF - Journal of Medical Internet Research AU - Rugs, Deborah AU - Toyinbo, Peter AU - Patel, Nitin AU - Powell-Cope, Gail AU - Hahm, Bridget AU - Elnitsky, Christine AU - Besterman-Dahan, Karen AU - Campbell, Robert AU - Sutton, Bryce AD - United States Veterans Health Administration, Center of Innovation on Disability & Rehabilitation Research, James A Haley Veterans Hospital, Mail Code 151R, 8900 Grand Oak Circle, Tampa, FL, 33636-1022, United States Y1 - 2013/11// PY - 2013 DA - November 2013 PB - Gunther Eysenbach MD MPH, Associate Professor, University of Toronto Senior Scientist, Centre for Global eHealth Innovation, Toronto, Canada VL - 15 IS - 11 SN - 1438-8871, 1438-8871 KW - back injuries KW - occupational injuries KW - moving and lifting patients KW - methods KW - program evaluation KW - Occupational health and safety KW - Federal government information KW - Patients KW - Military forces KW - Government agencies KW - article KW - 10.13: INFORMATION COMMUNICATION - SCIENCE, TECHNOLOGY, MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735638814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Internet+Research&rft.atitle=Processes+and+Outcomes+of+the+Veterans+Health+Administration+Safe+Patient+Handling+Program%3A+Study+Protocol&rft.au=Rugs%2C+Deborah%3BToyinbo%2C+Peter%3BPatel%2C+Nitin%3BPowell-Cope%2C+Gail%3BHahm%2C+Bridget%3BElnitsky%2C+Christine%3BBesterman-Dahan%2C+Karen%3BCampbell%2C+Robert%3BSutton%2C+Bryce&rft.aulast=Rugs&rft.aufirst=Deborah&rft.date=2013-11-01&rft.volume=15&rft.issue=11&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Internet+Research&rft.issn=14388871&rft_id=info:doi/10.2196%2Fresprot.2905 L2 - http://www.jmir.org/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Military forces; Federal government information; Government agencies; Patients; Occupational health and safety DO - http://dx.doi.org/10.2196/resprot.2905 ER - TY - JOUR T1 - The appraisal and management of uncertainty: Implications for information-retrieval systems AN - 1550992483; 201407455 AB - Uncertainty is an important idea in information-retrieval (IR) research, but the concept has yet to be fully elaborated and explored. Common assumptions about uncertainty are (a) that it is a negative (anxiety-producing) state and (b) that it will be reduced through information search and retrieval. Research in the domain of uncertainty in illness, however, has demonstrated that uncertainty is a complex phenomenon that shares a complicated relationship with information. Past research on people living with HIV and individuals who have tested positive for genetic risk for different illnesses has revealed that information and the reduction of uncertainty can, in fact, produce anxiety, and that maintaining uncertainty can be associated with optimism and hope. We review the theory of communication and uncertainty management and offer nine principles based on that theoretical work that can be used to influence IR system design. The principles reflect a view of uncertainty as a multi-faceted and dynamic experience, one subject to ongoing appraisal and management efforts that include interaction with and use of information in a variety of forms. Adapted from the source document. JF - Information Processing and Management AU - Brashers, Dale E AU - Hogan, Timothy P AD - Center for Health Quality, Outcomes and Economic Research, eHealth Quality Enhancement Research Initiative, National eHealth QUERI Coordinating Center, Edith Nourse Rogers Memorial Veterans Hospital, U.S. Department of Veterans Affairs, Bedford, MA, USA Y1 - 2013/11// PY - 2013 DA - November 2013 SP - 1241 EP - 1249 PB - Elsevier Ltd., Kidlington Oxford UK VL - 49 IS - 6 SN - 0306-4573, 0306-4573 KW - Uncertainty KW - Information retrieval KW - Appraisal KW - Anxiety KW - Hope KW - Systems design KW - Emotions KW - article KW - 13.0: COMPUTERIZED INFORMATION STORAGE AND RETRIEVAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1550992483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+Processing+and+Management&rft.atitle=The+appraisal+and+management+of+uncertainty%3A+Implications+for+information-retrieval+systems&rft.au=Brashers%2C+Dale+E%3BHogan%2C+Timothy+P&rft.aulast=Brashers&rft.aufirst=Dale&rft.date=2013-11-01&rft.volume=49&rft.issue=6&rft.spage=1241&rft.isbn=&rft.btitle=&rft.title=Information+Processing+and+Management&rft.issn=03064573&rft_id=info:doi/10.1016%2Fj.ipm.2013.06.002 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2014-08-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Uncertainty; Information retrieval; Emotions; Systems design; Anxiety DO - http://dx.doi.org/10.1016/j.ipm.2013.06.002 ER - TY - JOUR T1 - What Is Patient-Centered Care Really? Voices of Hispanic Prenatal Patients AN - 1496666380; 201401905 AB - Variations in patient-centered care (PCC) models and approaches contribute to ambiguity in how PCC is understood and defined, especially with regard to meeting the needs of diverse patient populations. One of the biggest challenges of putting PCC into practice is knowing what elements are the most important to patients. This qualitative study privileges patients' voices and adds a cultural dimension to existing health communication research on PCC through an empirical investigation of 48 Hispanic prenatal care patients' understandings and expectations of PCC. Semistructured interviews with 48 patients revealed five key themes in order of frequency: (a) una relacion amable (a friendly relationship), (b) la atencion medica efectiva (effective medical care), (c) Espanol hablado (the Spanish language spoken), (d) comprension de la informacion (understanding of information), and (e) eliminacion del racismo (elimination of racism). The themes reflected several different assumptions and expectations with regard to PCC as compared to those espoused in many of the existing models and frameworks, such as the extent to which friendly interpersonal behaviors (e.g., smiling, making eye contact, displaying patience, and engaging in formal greetings, introductions, and farewells) were critical to patient satisfaction with the health care experience. Not only did patients feel better understood, but accompanied by friendly behaviors, information was viewed as more believable and accurate, and thus more patient-centered. The findings suggest that implementing culturally sensitive PCC approaches to caring for Hispanic prenatal care patients can include training health care staff on the importance of displaying friendly communicative behaviors such as smiling. Adapted from the source document. JF - Health Communication AU - Bergman, Alicia A AU - Connaughton, Stacey L AD - Brian Lamb School of Communication, Purdue University alicia.bergman@va.gov Y1 - 2013/11// PY - 2013 DA - November 2013 SP - 789 EP - 799 PB - Taylor & Francis Group, Philadelphia PA VL - 28 IS - 8 SN - 1041-0236, 1041-0236 KW - Patient centredness KW - Antenatal care KW - Patient satisfaction KW - Health care KW - Hispanic people KW - Ambiguity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1496666380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Communication&rft.atitle=What+Is+Patient-Centered+Care+Really%3F+Voices+of+Hispanic+Prenatal+Patients&rft.au=Bergman%2C+Alicia+A%3BConnaughton%2C+Stacey+L&rft.aulast=Bergman&rft.aufirst=Alicia&rft.date=2013-11-01&rft.volume=28&rft.issue=8&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Health+Communication&rft.issn=10410236&rft_id=info:doi/10.1080%2F10410236.2012.725124 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - HECOER N1 - SubjectsTermNotLitGenreText - Patient centredness; Health care; Hispanic people; Antenatal care; Patient satisfaction; Ambiguity DO - http://dx.doi.org/10.1080/10410236.2012.725124 ER - TY - JOUR T1 - Easing Reintegration: Telephone Support Groups for Spouses of Returning Iraq and Afghanistan Service Members AN - 1496664890; 201403184 AB - Spouses of returning Iraq (Operation Iraqi Freedom, OIF) and Afghanistan (Operation Enduring Freedom, OEF) military service members report increased depression and anxiety post deployment as they work to reintegrate the family and service member. Reconnecting the family, renegotiating roles that have shifted, reestablishing communication patterns, and dealing with mental health concerns are all tasks that spouses must undertake as part of reintegration. We tested telephone support groups focusing on helping spouses with these basic reintegration tasks. Year-long telephone support groups focused on education, skills building (communication skills, problem solving training, cognitive behavioral techniques, stress management), and support. Spouse depression and anxiety were decreased and perceived social support was increased during the course of the study. In subgroup analyses, spouses with husbands whose injuries caused care difficulties had a positive response to the intervention. However, they were more likely to be depressed, be anxious, and have less social support compared to participants who had husbands who had no injury or whose injury did not cause care difficulty. Study findings suggest that this well-established, high-access intervention can help improve quality of life for military spouses who are struggling with reintegration of the service member and family. Adapted from the source document. JF - Health Communication AU - Nichols, Linda Olivia AU - Martindale-Adams, Jennifer AU - Graney, Marshall J AU - Zuber, Jeffrey AU - Burns, Robert AD - Veterans Affairs Medical Center and Departments of Preventive Medicine and Internal Medicine, University of Tennessee Health Science Center linda.nichols@va.gov Y1 - 2013/11// PY - 2013 DA - November 2013 SP - 767 EP - 777 PB - Taylor & Francis Group, Philadelphia PA VL - 28 IS - 8 SN - 1041-0236, 1041-0236 KW - Servicemen KW - Telephone support groups KW - Afghanistan KW - Reintegration KW - Anxiety-Depression KW - Spouses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1496664890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Communication&rft.atitle=Easing+Reintegration%3A+Telephone+Support+Groups+for+Spouses+of+Returning+Iraq+and+Afghanistan+Service+Members&rft.au=Nichols%2C+Linda+Olivia%3BMartindale-Adams%2C+Jennifer%3BGraney%2C+Marshall+J%3BZuber%2C+Jeffrey%3BBurns%2C+Robert&rft.aulast=Nichols&rft.aufirst=Linda&rft.date=2013-11-01&rft.volume=28&rft.issue=8&rft.spage=767&rft.isbn=&rft.btitle=&rft.title=Health+Communication&rft.issn=10410236&rft_id=info:doi/10.1080%2F10410236.2013.800439 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - HECOER N1 - SubjectsTermNotLitGenreText - Spouses; Anxiety-Depression; Reintegration; Servicemen; Telephone support groups; Afghanistan DO - http://dx.doi.org/10.1080/10410236.2013.800439 ER - TY - JOUR T1 - Provider proximity as a predictor of referral rate and success AN - 1496663861; 201400235 AB - The predictive utility of proximity of primary care providers (PCPs) to mental health providers (MHPs) in referral rate and referral success was examined. Referrals from all PCPs in three New Jersey primary care clinics with primary care mental health integration (PC-MHI) to MHPs for fiscal year 2009 (October 1, 2008 through September 30, 2009) were included. Regression analyses supported the hypotheses that proximity significantly predicts both rate of referral per visit and rate of referral per unique patient. The hypothesis that proximity predicts referral success was not supported. Further research might seek to determine if additional variables moderate the relationship between provider proximity and referral rate. Implications of the findings for colocated programs were discussed. [Copyright Elsevier B.V.] JF - Psychological Services AU - Calkins, Lauri E AU - Michelson, Ilysa R AU - Corso, Andrew S Y1 - 2013/11// PY - 2013 DA - November 2013 SP - 395 EP - 400 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 10 IS - 4 SN - 1541-1559, 1541-1559 KW - PC-MHI KW - collaborative care KW - colocated KW - proximity KW - referral rate KW - primary care providers KW - Mental health care KW - Referrals KW - Proximity KW - Primary health care KW - Clinics KW - New Jersey KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1496663861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Provider+proximity+as+a+predictor+of+referral+rate+and+success&rft.au=Calkins%2C+Lauri+E%3BMichelson%2C+Ilysa+R%3BCorso%2C+Andrew+S&rft.aulast=Calkins&rft.aufirst=Lauri&rft.date=2013-11-01&rft.volume=10&rft.issue=4&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0029988 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-01-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Referrals; Proximity; Primary health care; Mental health care; Clinics; New Jersey DO - http://dx.doi.org/10.1037/a0029988 ER - TY - JOUR T1 - Nontoxigenic Clostridium difficile Protects Hamsters against Challenge with Historic and Epidemic Strains of Toxigenic BI/NAP1/027 C. difficile AN - 1458539095; 18745811 AB - Nontoxigenic Clostridium difficile (NTCD) has been shown to prevent fatal C. difficile infection in the hamster model when hamsters are challenged with standard toxigenic C. difficile strains. The purpose of this study was to determine if NTCD can prevent C. difficile infection in the hamster model when hamsters are challenged with restriction endonuclease analysis group BI C. difficile strains. Groups of 10 hamsters were given oral clindamycin, followed on day 2 by 106 CFU of spores of NTCD strain M3 or T7, and were challenged on day 5 with 100 CFU of spores of BI1 or BI6. To conserve animals, results for control hamsters challenged with BI1 or BI6 from the present study and controls from previous identical experiments were combined for statistical comparisons. NTCD strains M3 and T7 achieved 100% colonization and were 100% protective against challenge with BI1 (P less than or equal to 0.001). M3 colonized 9/10 hamsters and protected against BI6 challenge in the colonized hamsters (P = 0.0003). T7 colonized 10/10 hamsters, but following BI6 challenge, cocolonization occurred in 5 hamsters, 4 of which died, for protection of 6/10 animals (P = 0.02). NTCD colonization provides protection against challenge with toxigenic BI group strains. M3 is more effective than T7 in preventing C. difficile infection caused by the BI6 epidemic strain. Prevention of C. difficile infection caused by the epidemic BI6 strain may be more challenging than that of infections caused by historic BI1 and non-BI C. difficile strains. JF - Antimicrobial Agents & Chemotherapy AU - Nagaro, Kristin J AU - Phillips, S Tyler AU - Cheknis, Adam K AU - Sambol, Susan P AU - Zukowski, Walter E AU - Johnson, Stuart AU - Gerding, Dale N Y1 - 2013/11// PY - 2013 DA - Nov 2013 SP - 5266 EP - 5270 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 57 IS - 11 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Historical account KW - Clindamycin KW - Epidemics KW - Statistics KW - Chemotherapy KW - Animal models KW - Infection KW - Antimicrobial agents KW - Colonization KW - Prevention KW - Colony-forming cells KW - Clostridium difficile KW - Spores KW - Endonuclease KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1458539095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Nontoxigenic+Clostridium+difficile+Protects+Hamsters+against+Challenge+with+Historic+and+Epidemic+Strains+of+Toxigenic+BI%2FNAP1%2F027+C.+difficile&rft.au=Nagaro%2C+Kristin+J%3BPhillips%2C+S+Tyler%3BCheknis%2C+Adam+K%3BSambol%2C+Susan+P%3BZukowski%2C+Walter+E%3BJohnson%2C+Stuart%3BGerding%2C+Dale+N&rft.aulast=Nagaro&rft.aufirst=Kristin&rft.date=2013-11-01&rft.volume=57&rft.issue=11&rft.spage=5266&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00580-13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-11-01 N1 - Number of references - 27 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Colonization; Clindamycin; Statistics; Epidemics; Colony-forming cells; Animal models; Endonuclease; Spores; Infection; Historical account; Prevention; Chemotherapy; Antimicrobial agents; Clostridium difficile DO - http://dx.doi.org/10.1128/AAC.00580-13 ER - TY - JOUR T1 - N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement. AN - 1443994240; 23965381 AB - Impaired transmission through glutamatergic circuits has been postulated to play a role in the underlying pathophysiology of schizophrenia. Furthermore, inhibition of the N-methyl-d-aspartate (NMDA) subtype of ionotropic glutamate receptors (NMDAR) induces a syndrome that recapitulates many of the symptoms observed in patients with schizophrenia. Selective activation of metabotropic glutamate receptor subtype 5 (mGlu5) may provide a novel therapeutic approach for treatment of symptoms associated with schizophrenia through facilitation of transmission through central glutamatergic circuits. Here, we describe the characterization of two novel N-aryl piperazine mGlu5 positive allosteric modulators (PAMs): 2-(4-(2-(benzyloxy)acetyl)piperazin-1-yl)benzonitrile (VU0364289) and 1-(4-(2,4-difluorophenyl)piperazin-1-yl)-2-((4-fluorobenzyl)oxy)ethanone (DPFE). VU0364289 and DPFE induced robust leftward shifts in the glutamate concentration-response curves for Ca(2+) mobilization and extracellular signal-regulated kinases 1 and 2 phosphorylation. Both PAMs displayed micromolar affinity for the common mGlu5 allosteric binding site and high selectivity for mGlu5. VU0364289 and DPFE possessed suitable pharmacokinetic properties for dosing in vivo and produced robust dose-related effects in reversing amphetamine-induced hyperlocomotion, a preclinical model predictive of antipsychotic-like activity. In addition, DPFE enhanced acquisition of contextual fear conditioning in rats and reversed behavioral deficits in a mouse model of NMDAR hypofunction. In contrast, DPFE had no effect on reversing apomorphine-induced disruptions of prepulse inhibition of the acoustic startle reflex. These mGlu5 PAMs also increased monoamine levels in the prefrontal cortex, enhanced performance in a hippocampal-mediated memory task, and elicited changes in electroencephalogram dynamics commensurate with procognitive effects. Collectively, these data support and extend the role for the development of novel mGlu5 PAMs for the treatment of psychosis and cognitive deficits observed in individuals with schizophrenia. JF - The Journal of pharmacology and experimental therapeutics AU - Gregory, K J AU - Herman, E J AU - Ramsey, A J AU - Hammond, A S AU - Byun, N E AU - Stauffer, S R AU - Manka, J T AU - Jadhav, S AU - Bridges, T M AU - Weaver, C D AU - Niswender, C M AU - Steckler, T AU - Drinkenburg, W H AU - Ahnaou, A AU - Lavreysen, H AU - Macdonald, G J AU - Bartolomé, J M AU - Mackie, C AU - Hrupka, B J AU - Caron, M G AU - Daigle, T L AU - Lindsley, C W AU - Conn, P J AU - Jones, C K AD - Department of Pharmacology and Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee (K.J.G., E.J.H., A.S.H., N.E.B., S.R.S., J.T.M., S.J., T.M.B., C.D.W., C.M.N., C.W.L., P.J.C., C.K.J.); Drug Discovery Biology, MIPS, Monash University, Parkville, Victoria, Australia (K.J.G.); Department of Pharmacology and Toxicology, University of Toronto, Ontario, Canada (A.J.R.); Institute of Imaging and Science, Vanderbilt University (N.E.B.); Janssen Research & Development, Beerse, Belgium (T.S., W.H.D., A.A., H.L., G.J.M., C.M., B.J.H.); Janssen Research & Development, Toledo, Spain (J.M.B.); Department of Cell Biology, Duke University, Durham, North Carolina (M.G.C., T.L.D.); Department of Chemistry, Vanderbilt University Medical Center, Nashville, Tennessee (C.W.L.); and U.S. Department of Veterans Affairs, Nashville, Tennessee (C.K.J.). Y1 - 2013/11// PY - 2013 DA - November 2013 SP - 438 EP - 457 VL - 347 IS - 2 KW - 1-(4-(2,4-difluorophenyl)piperazin-1-yl)-2-((4-fluorobenzyl)oxy)ethanone KW - 0 KW - 2-(4-(2-(benzyloxy)acetyl)piperazin-1-yl)benzonitrile KW - Antipsychotic Agents KW - Grm5 protein, rat KW - NR1 NMDA receptor KW - Nootropic Agents KW - Piperazines KW - Receptor, Metabotropic Glutamate 5 KW - Receptors, N-Methyl-D-Aspartate KW - Index Medicus KW - Animals KW - Maze Learning -- drug effects KW - Schizophrenia -- metabolism KW - Dose-Response Relationship, Drug KW - HEK293 Cells KW - Humans KW - Mice KW - Mice, Knockout KW - Rats KW - Rats, Sprague-Dawley KW - Transfection KW - Schizophrenia -- drug therapy KW - Allosteric Regulation KW - Motor Activity -- drug effects KW - Drug Evaluation, Preclinical KW - Male KW - Piperazines -- chemistry KW - Piperazines -- therapeutic use KW - Antipsychotic Agents -- pharmacology KW - Antipsychotic Agents -- therapeutic use KW - Nootropic Agents -- pharmacokinetics KW - Receptor, Metabotropic Glutamate 5 -- genetics KW - Receptors, N-Methyl-D-Aspartate -- metabolism KW - Antipsychotic Agents -- chemistry KW - Piperazines -- pharmacology KW - Hyperkinesis -- metabolism KW - Nootropic Agents -- chemistry KW - Nootropic Agents -- pharmacology KW - Memory, Short-Term -- drug effects KW - Hyperkinesis -- drug therapy KW - Piperazines -- pharmacokinetics KW - Antipsychotic Agents -- pharmacokinetics KW - Receptor, Metabotropic Glutamate 5 -- agonists KW - Nootropic Agents -- therapeutic use KW - Receptors, N-Methyl-D-Aspartate -- genetics KW - Hyperkinesis -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1443994240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=N-aryl+piperazine+metabotropic+glutamate+receptor+5+positive+allosteric+modulators+possess+efficacy+in+preclinical+models+of+NMDA+hypofunction+and+cognitive+enhancement.&rft.au=Gregory%2C+K+J%3BHerman%2C+E+J%3BRamsey%2C+A+J%3BHammond%2C+A+S%3BByun%2C+N+E%3BStauffer%2C+S+R%3BManka%2C+J+T%3BJadhav%2C+S%3BBridges%2C+T+M%3BWeaver%2C+C+D%3BNiswender%2C+C+M%3BSteckler%2C+T%3BDrinkenburg%2C+W+H%3BAhnaou%2C+A%3BLavreysen%2C+H%3BMacdonald%2C+G+J%3BBartolom%C3%A9%2C+J+M%3BMackie%2C+C%3BHrupka%2C+B+J%3BCaron%2C+M+G%3BDaigle%2C+T+L%3BLindsley%2C+C+W%3BConn%2C+P+J%3BJones%2C+C+K&rft.aulast=Gregory&rft.aufirst=K&rft.date=2013-11-01&rft.volume=347&rft.issue=2&rft.spage=438&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.113.206623 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-12-23 N1 - Date created - 2013-10-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Endocrinol Diabetes Obes. 2010 Oct;17(5):460-6 [20717020] Eur J Pharmacol. 2010 Aug 10;639(1-3):40-6 [20371241] Mol Pharmacol. 2010 Dec;78(6):1105-23 [20923853] Bioorg Med Chem Lett. 2010 Dec 15;20(24):7381-4 [21067920] Eur J Pharmacol. 2011 Feb 25;653(1-3):47-57 [21147094] Neuropsychopharmacology. 2011 Mar;36(4):782-92 [21150906] Eur J Pharmacol. 2011 Jun 1;659(2-3):146-54 [21335002] Mol Pharmacol. 2012 Feb;81(2):120-33 [22021324] Neuropharmacology. 2012 Mar;62(3):1453-60 [21112344] Neuropsychopharmacology. 2012 Mar;37(4):1057-66 [22129780] J Neurosci. 2012 Jun 20;32(25):8532-44 [22723693] Neuropharmacology. 2013 Jan;64:240-7 [22884612] Neuropharmacology. 2013 Jan;64:224-39 [22884720] Dev Neurosci. 2012;34(2-3):159-73 [22571986] Handb Exp Pharmacol. 2012;(213):297-365 [23027420] Mol Pharmacol. 2012 Nov;82(5):860-75 [22863693] Bioorg Med Chem Lett. 2012 Dec 15;22(24):7388-92 [23142615] Biol Psychiatry. 2013 Mar 15;73(6):501-9 [23140665] Mol Pharmacol. 2013 Apr;83(4):835-47 [23348500] Mol Pharmacol. 2013 May;83(5):991-1006 [23444015] Br J Pharmacol. 1999 Nov;128(5):1055-63 [10556943] Neuropsychopharmacology. 2000 Jun;22(6):642-9 [10788763] Arch Gen Psychiatry. 2002 Jul;59(7):663-4 [12090822] Curr Drug Targets CNS Neurol Disord. 2002 Apr;1(2):163-81 [12769625] J Pharmacol Exp Ther. 2003 Jul;306(1):116-23 [12660307] Genes Brain Behav. 2004 Oct;3(5):287-302 [15344922] Biochem Pharmacol. 1973 Dec 1;22(23):3099-108 [4202581] Am J Psychiatry. 1991 Oct;148(10):1301-8 [1654746] Behav Neurosci. 1992 Apr;106(2):274-85 [1590953] Trends Pharmacol Sci. 1998 Sep;19(9):351-7 [9786022] Cell. 1999 Aug 20;98(4):427-36 [10481908] AMA Arch Neurol Psychiatry. 1959 Mar;81(3):363-9 [13626287] Br J Pharmacol Chemother. 1959 Mar;14(1):48-58 [13651579] J Pharmacol Exp Ther. 2005 Mar;312(3):1055-63 [15574685] J Pharmacol Exp Ther. 2005 Apr;313(1):199-206 [15608073] J Clin Psychiatry. 2005 Sep;66(9):1122-9 [16187769] Mol Pharmacol. 2005 Dec;68(6):1793-802 [16155210] Arch Neurol. 2006 Oct;63(10):1372-6 [17030651] Biol Psychiatry. 2006 Nov 15;60(10):1111-20 [16806100] J Clin Psychiatry. 2006 Oct;67(10):e12 [17107235] Int Rev Neurobiol. 2007;78:69-108 [17349858] Mol Pharmacol. 2007 May;71(5):1389-98 [17303702] Trends Pharmacol Sci. 2007 Aug;28(8):382-9 [17629965] J Med Chem. 2008 Feb 14;51(3):634-47 [18173231] Mol Pharmacol. 2008 Mar;73(3):909-18 [18056795] Mol Pharmacol. 2008 Apr;73(4):1213-24 [18171729] Psychiatr Serv. 2008 May;59(5):500-6 [18451005] Neuropsychopharmacology. 2008 Oct;33(11):2701-14 [18185498] J Neurosci. 2008 Oct 8;28(41):10422-33 [18842902] J Pharmacol Exp Ther. 2008 Dec;327(3):827-39 [18753411] J Neurosci. 2009 Jun 24;29(25):8215-24 [19553461] Neuropsychopharmacology. 2009 Aug;34(9):2057-71 [19295507] Genes Brain Behav. 2009 Oct;8(7):661-75 [19563516] Eur J Pharmacol. 2009 Nov 25;623(1-3):73-83 [19765575] Neuropsychopharmacology. 2010 Mar;35(4):855-69 [19940843] Pharmacol Biochem Behav. 2010 Mar;95(1):23-30 [19995568] Prog Brain Res. 2009;179:51-8 [20302817] Hum Psychopharmacol. 2010 Aug;25(6):439-47 [20737517] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1124/jpet.113.206623 ER - TY - JOUR T1 - Cold climates demand more intertemporal self-control than warm climates AN - 1567046186; 201437580 AB - A climate that is too cold to grow crops for part of the year demands foresight and self-control skills. To the extent that a culture has developed intertemporal bargaining, its members will have more autonomy, but pay the cost of being more compulsive, than members of societies that have not. Monetary resources will be a consequence but will also be fed back as a cause. Adapted from the source document. JF - Behavioral and Brain Sciences AU - Ainslie, George AD - School of Economics, University of Cape Town, Rondebosch 7701, South Africa; Department of Veterans Affairs, Coatesville, PA 19320. www.picoeconomics.org George.Ainslie@va.gov Y1 - 2013/10// PY - 2013 DA - October 2013 SP - 481 EP - 482 PB - Cambridge University Press, New York NY VL - 36 IS - 5 SN - 0140-525X, 0140-525X KW - Skills KW - Will KW - Autonomy KW - Self Control KW - article KW - 2682: environmental interactions; social geography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1567046186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+Brain+Sciences&rft.atitle=Cold+climates+demand+more+intertemporal+self-control+than+warm+climates&rft.au=Ainslie%2C+George&rft.aulast=Ainslie&rft.aufirst=George&rft.date=2013-10-01&rft.volume=36&rft.issue=5&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+Brain+Sciences&rft.issn=0140525X&rft_id=info:doi/10.1017%2FS0140525X13000022 LA - English DB - Sociological Abstracts N1 - Date revised - 2014-10-01 N1 - Number of references - 9 N1 - Last updated - 2016-09-28 N1 - CODEN - BBSCDH N1 - SubjectsTermNotLitGenreText - Self Control; Skills; Autonomy; Will DO - http://dx.doi.org/10.1017/S0140525X13000022 ER - TY - JOUR T1 - Healthcare Utilization and Symptom Variation Among Veterans Using Behavioral Telehealth Center Services AN - 1558995628; 201431298 AB - Substance use and mental health problems are often underdiagnosed and undertreated in primary care. Veterans affairs facilities are using the Behavioral Telehealth Center (BTC) to provide evidence-based assessments for primary care patients via telephone. Whether participation in BTC services is associated with (1) increases in healthcare utilization and (2) decreases in symptoms based on behavioral health screening instruments, post-BTC services compared with pre-BTC services were investigated. Retrospective data were extracted for 1,820 patients who were referred to the BTC. Differences in utilization rates and symptom scores pre- and post-BTC services were tested using repeated measures analysis of covariance while controlling for relevant sociodemographic variables. Participants (1) utilized significantly more substance use and mental health treatment services and (2) had significantly lower alcohol and depression screening scores post-BTC services compared with pre-BTC services. This initial evaluation provides support that BTC services are associated with increased healthcare utilization and decreased alcohol and depressive symptoms. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Possemato, Kyle AU - Bishop, Todd M AU - Willis, Matthew A AU - Lantinga, Larry J AD - Syracuse Veterans Affairs Medical, Center for Integrated Healthcare, 800 Irving Avenue-116C, Syracuse, NY, 13210, USA kyle.possemato@va.gov Y1 - 2013/10// PY - 2013 DA - October 2013 SP - 416 EP - 426 PB - Springer, US VL - 40 IS - 4 SN - 1094-3412, 1094-3412 KW - Veterans KW - Symptoms KW - Mental health services KW - Telemedicine KW - Substance abuse KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558995628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Healthcare+Utilization+and+Symptom+Variation+Among+Veterans+Using+Behavioral+Telehealth+Center+Services&rft.au=Possemato%2C+Kyle%3BBishop%2C+Todd+M%3BWillis%2C+Matthew+A%3BLantinga%2C+Larry+J&rft.aulast=Possemato&rft.aufirst=Kyle&rft.date=2013-10-01&rft.volume=40&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-013-9338-y LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Number of references - 28 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Helpseeking; Substance abuse; Symptoms; Telemedicine; Mental health services; Veterans DO - http://dx.doi.org/10.1007/s11414-013-9338-y ER - TY - JOUR T1 - The Differential Impact of Terrorism on Two Israeli Communities AN - 1504420996; 201401338 AB - The authors evaluated 2 cohorts of individuals from different Israeli communities (Sderot and Otef Aza) that are repeatedly subjected to potentially lethal missile attacks. Although both communities border the Gaza Strip and face similar levels of threat, the authors hypothesized that the Sderot cohort would endorse higher rates of stress-related symptoms because it has fewer mitigating economic and psychosocial resources. The authors further hypothesized that there would be a significant relationship between exposure to terror and psychopathology regardless of community context. To test these predictions, the authors compared the levels of exposure to terror, posttraumatic stress disorder (PTSD), and depression in representative samples of adults from the 2 communities (n = 298 and n = 152, respectively). Residents of Sderot had a much higher rate of probable PTSD (35.2% vs. 6.6%), and community context was the most important predictor of PTSD and depression. The study also revealed a significant relationship between exposure and psychopathology, but for Sderot residents only. The conclusion is that researchers, mental health workers, and policy makers should pay attention to the influence of community characteristics, such as the availability of resources, the general sense of support, and the level of solidarity, on the mental health response to exposure to terror. [Copyright American Psychological Association] JF - American Journal of Orthopsychiatry AU - Stein, Nathan R AU - Schorr, Yonit AU - Krantz, Lillian AU - Dickstein, Benjamin D AU - Solomon, Zahava AU - Horesh, Danny AU - Litz, Brett T Y1 - 2013/10// PY - 2013 DA - October 2013 SP - 528 EP - 535 PB - John Wiley & Sons, Inc. VL - 83 IS - 4 SN - 0002-9432, 0002-9432 KW - Israeli communities terrorism exposure to terror stress-related symptoms posttraumatic stress disorder depression dose-response relationship rocket attacks kibbutz moshav KW - Depression (Economics) KW - Policy Making KW - Borders KW - Terrorism KW - Depression (Psychology) KW - Mental Health Services KW - Psychopathology KW - Threat KW - Posttraumatic Stress Disorder KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504420996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Orthopsychiatry&rft.atitle=The+Differential+Impact+of+Terrorism+on+Two+Israeli+Communities&rft.au=Stein%2C+Nathan+R%3BSchorr%2C+Yonit%3BKrantz%2C+Lillian%3BDickstein%2C+Benjamin+D%3BSolomon%2C+Zahava%3BHoresh%2C+Danny%3BLitz%2C+Brett+T&rft.aulast=Stein&rft.aufirst=Nathan&rft.date=2013-10-01&rft.volume=83&rft.issue=4&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Orthopsychiatry&rft.issn=00029432&rft_id=info:doi/10.1111%2Fajop.12044 LA - English DB - Social Services Abstracts N1 - Date revised - 2014-03-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJORAG N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Psychopathology; Depression (Psychology); Borders; Policy Making; Threat; Depression (Economics); Mental Health Services; Terrorism DO - http://dx.doi.org/10.1111/ajop.12044 ER - TY - JOUR T1 - Antibiotic prescription practices for pneumonia, skin and soft tissue infections and urinary tract infections throughout the US Veterans Affairs system AN - 1492616098; 18892407 AB - Objectives Currently used metrics for antibiotic utilization are not linked to a diagnosis and may be difficult to interpret. We aimed to describe patterns and variation in antibiotic management of three common infectious disease diagnoses in Veterans Affairs Medical Centers (VAMCs). Methods This descriptive retrospective cohort study included all veterans discharged between 2007 and 2009 after an acute care admission to a VAMC and a principal ICD-9-CM code for pneumonia (PNEU), skin and soft-tissue infections (SSTI), urinary tract infections (UTI) or non-infectious disease-related diagnoses (NON_INF). Systemic antibiotic use was assessed based on barcode medication administration data. A treatment period was defined as a time of uninterrupted inpatient antibiotic therapy with no gaps of >1 calendar day. Results Over the study period there were 1.44 million discharges with an acute care admission to 128 VAMCs included in the study. Of the discharges, 58118 had a primary ICD-9-CM diagnosis classifiable as PNEU, 36797 as SSTI, 30223 as UTI and 1243098 as NON_INF. Empirical antibiotic use during the first 2 hospital days was frequent for all infectious disease diagnoses. Type of empirical coverage varied among facilities for all conditions, as did treatment durations. Roughly half of all empirical courses of therapy where the patient was still hospitalized on day 4 did not exhibit any change to the antibiotic regimen. Conclusions There is substantial variation in the management of common infectious diseases with regard to choice of empirical agents and duration of therapy. Diagnosis-specific antibiotic use metrics may prove useful for antibiotic stewardship programmes. JF - Journal of Antimicrobial Chemotherapy AU - Huttner, Benedikt AU - Jones, Makoto AU - Huttner, Angela AU - Rubin, Michael AU - Samore, Matthew H AD - Corresponding author. VA Salt Lake City Health Care System, 500 Foothill Drive, Salt Lake City, UT 84148, USA. Tel: +1-801-582-1565 ext 4474, makoto.jones@va.gov Y1 - 2013/10// PY - 2013 DA - Oct 2013 SP - 2393 EP - 2399 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 68 IS - 10 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Antibiotics KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1492616098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Antibiotic+prescription+practices+for+pneumonia%2C+skin+and+soft+tissue+infections+and+urinary+tract+infections+throughout+the+US+Veterans+Affairs+system&rft.au=Huttner%2C+Benedikt%3BJones%2C+Makoto%3BHuttner%2C+Angela%3BRubin%2C+Michael%3BSamore%2C+Matthew+H&rft.aulast=Huttner&rft.aufirst=Benedikt&rft.date=2013-10-01&rft.volume=68&rft.issue=10&rft.spage=2393&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkt171 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-12-01 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - Antibiotics DO - http://dx.doi.org/10.1093/jac/dkt171 ER - TY - JOUR T1 - Lessons Learned from Two Peer-Led Mutual Support Groups AN - 1463071482; 201326634 AB - This case report and analysis describe the formation of two peer-led mutual support groups conducted within the context of a Veterans Administration Medical Center. Based on our assessment of the success of one of these groups and the failure of the other, we offer several recommendations and suggestions to help promote this modality. More specifically, we hypothesize that such groups are more likely to be successful (1) if participants are transferred en masse from another group, (2) that, at least initially, housing the group in the same context as formal clinician-led groups or overlapping clinician-led and peer-led groups may help smooth the transition from authority-led treatment to a mutual peer support format, and finally, (3) that prior experiences in interpersonal process groups may promote the skills and cohesion to promote successful transition to mutual support. Adapted from the source document. JF - International Journal of Group Psychotherapy AU - Viverito, Kristen M AU - Cardin, Scott A AU - Johnson, Leigh Ann AU - Owen, Richard R AD - Central Arkansas Veterans Healthcare System, 2200 Fort Roots Drive, Building 58 (152/NLR), North Little Rock, AR 72114 kristen.viverito@va.gov Y1 - 2013/10// PY - 2013 DA - October 2013 SP - 593 EP - 600 PB - Guilford Publications, New York NY VL - 63 IS - 4 SN - 0020-7284, 0020-7284 KW - Assessment KW - Process groups KW - Housing KW - Cohesion KW - Military hospitals KW - Mutual support KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463071482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Group+Psychotherapy&rft.atitle=Lessons+Learned+from+Two+Peer-Led+Mutual+Support+Groups&rft.au=Viverito%2C+Kristen+M%3BCardin%2C+Scott+A%3BJohnson%2C+Leigh+Ann%3BOwen%2C+Richard+R&rft.aulast=Viverito&rft.aufirst=Kristen&rft.date=2013-10-01&rft.volume=63&rft.issue=4&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Group+Psychotherapy&rft.issn=00207284&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - IJGPAO N1 - SubjectsTermNotLitGenreText - Mutual support; Assessment; Process groups; Housing; Cohesion; Military hospitals ER - TY - JOUR T1 - Gender Differences in the Risk and Protective Factors Associated With PTSD: A Prospective Study of National Guard Troops Deployed to Iraq AN - 1463069652; 201326068 AB - This study examines gender differences in post-traumatic stress symptoms (PTSS) and PTSS risk/protective factors among soldiers deployed to Iraq. We pay special attention to two potentially modifiable military factors, military preparedness and unit cohesion, which may buffer the deleterious psychological effects of combat. Longitudinal data were collected on 922 New Jersey National Guard soldiers (91 women) deployed to Iraq in 2008. Anonymous surveys administered at pre- and post-deployment included the PTSD Checklist (PCL), the Unit Support Scale, and a preparedness scale adapted from the Iowa Gulf War Study. Bivariate analyses and hierarchical multiple regression were used to identify predictors of PTSS and their explanatory effects on the relationship between gender and PTSS. Women had a higher prevalence of probable post-deployment PTSD than men (18.7% vs. 8.7%; OR = 2.45; CI [1.37, 4.37]) and significantly higher post-deployment PTSS (33.73 vs. 27.37; p = .001). While there were no gender differences in combat exposure, women scored higher on pre-deployment PTSS (26.9 vs. 23.1; p less than or equal to .001) and lower on military preparedness (1.65 vs. 2.41; p less than or equal to .001) and unit cohesion (32.5 vs. 38.1; p less than or equal to .001). In a multivariate model, controlling for all PTSS risk/resilience factors reduced the gender difference as measured by the unstandardized Beta (B) by 45%, with 18% uniquely attributable to low cohesion and low preparedness. In the fully controlled model, gender remained a significant predictor of PTSS but the effect size was small (d = .26). Modifiable military institutional factors may account for much of the increased vulnerability of women soldiers to PTSD. Adapted from the source document. JF - Psychiatry AU - Kline, Anna AU - Ciccone, Donald S AU - Weiner, Marc AU - Interian, Alejandro AU - Hill, Lauren St AU - Falca-Dodson, Maria AU - Black, Christopher M AU - Losonczy, Miklos AD - VA New Jersey Health Care System, 151 Knollcroft Rd., Box 116A, Lyons, NJ 07939 anna.kline@va.gov Y1 - 2013/10// PY - 2013 DA - October 2013 SP - 256 EP - 272 PB - The Guilford Press VL - 76 IS - 3 SN - 0033-2747, 0033-2747 KW - Posttraumatic stress disorder KW - Soldiers KW - Women KW - Preparedness KW - Gender differences KW - Iraq KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463069652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry&rft.atitle=Gender+Differences+in+the+Risk+and+Protective+Factors+Associated+With+PTSD%3A+A+Prospective+Study+of+National+Guard+Troops+Deployed+to+Iraq&rft.au=Kline%2C+Anna%3BCiccone%2C+Donald+S%3BWeiner%2C+Marc%3BInterian%2C+Alejandro%3BHill%2C+Lauren+St%3BFalca-Dodson%2C+Maria%3BBlack%2C+Christopher+M%3BLosonczy%2C+Miklos&rft.aulast=Kline&rft.aufirst=Anna&rft.date=2013-10-01&rft.volume=76&rft.issue=3&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Psychiatry&rft.issn=00332747&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PSYCAB N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Gender differences; Preparedness; Iraq; Women; Soldiers ER - TY - JOUR T1 - Grasping the Impalpable: The Role of Endogenous Reward in Choices, Including Process Addictions AN - 1463011701; 201347258 AB - The list of proposed addictions has recently grown to include television, videogames, shopping, day trading, kleptomania, and use of the Internet. These activities share with a more established entry, gambling, the property that they require no delivery of a biological stimulus that might be thought to unlock a hardwired brain process. I propose a framework for analyzing that class of incentives that do not depend on the prediction of physically privileged environmental events: people have a great capacity to coin endogenous reward; we learn to cultivate it, and, where it is entrapping, to minimize it, by managing internally generated appetites for it. The basic method of cultivating endogenous reward is to learn cues that predict when best to harvest the reward that has been made possible by the growth of these appetites. This hedonic management occurs in the same motivational marketplace as the instrumental planning that seeks environmental goods in the conventional manner, and presumably obeys the same laws of temporal difference learning; but these laws are no longer limiting. Furthermore, instrumental contingencies often provide the most productive structure for hedonic management as well, for reasons that I discuss; but the needs of hedonic management create incentives both to pursue instrumental goals in a suboptimal manner and to avoid noticing how the hedonic incentive affects this pursuit. The result is the apparent irrationality that is often observed in process addictions. Adapted from the source document. JF - Inquiry: an interdisciplinary journal of philosophy AU - Ainslie, George AD - University of Cape Town, South Africa George.Ainslie@va.gov Y1 - 2013/10// PY - 2013 DA - October 2013 SP - 446 EP - 469 PB - Taylor & Francis, Oslo Norway VL - 56 IS - 5 SN - 0020-174X, 0020-174X KW - Management KW - Resource Management KW - Television KW - Choices KW - Brain KW - Irrationality KW - Addiction KW - Internet KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463011701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inquiry%3A+an+interdisciplinary+journal+of+philosophy&rft.atitle=Grasping+the+Impalpable%3A+The+Role+of+Endogenous+Reward+in+Choices%2C+Including+Process+Addictions&rft.au=Ainslie%2C+George&rft.aulast=Ainslie&rft.aufirst=George&rft.date=2013-10-01&rft.volume=56&rft.issue=5&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Inquiry%3A+an+interdisciplinary+journal+of+philosophy&rft.issn=0020174X&rft_id=info:doi/10.1080%2F0020174X.2013.806129 LA - English DB - Sociological Abstracts N1 - Date revised - 2013-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - IQRYAJ N1 - SubjectsTermNotLitGenreText - Addiction; Management; Resource Management; Irrationality; Television; Brain; Internet; Choices DO - http://dx.doi.org/10.1080/0020174X.2013.806129 ER - TY - JOUR T1 - Structures of the Class D Carbapenemases OXA-23 and OXA-146: Mechanistic Basis of Activity against Carbapenems, Extended-Spectrum Cephalosporins, and Aztreonam AN - 1443377708; 18642382 AB - Class D beta -lactamases that hydrolyze carbapenems such as imipenem and doripenem are a recognized danger to the efficacy of these "last-resort" beta -lactam antibiotics. Like all known class D carbapenemases, OXA-23 cannot hydrolyze the expanded-spectrum cephalosporin ceftazidime. OXA-146 is an OXA-23 subfamily clinical variant that differs from the parent enzyme by a single alanine (A220) inserted in the loop connecting beta -strands beta 5 and beta 6. We discovered that this insertion enables OXA-146 to bind and hydrolyze ceftazidime with an efficiency comparable to those of other extended-spectrum class D beta -lactamases. OXA-146 also binds and hydrolyzes aztreonam, cefotaxime, ceftriaxone, and ampicillin with higher efficiency than OXA-23 and preserves activity against doripenem. In this study, we report the X-ray crystal structures of both the OXA-23 and OXA-146 enzymes at 1.6-Aa and 1.2-Aa resolution. A comparison of the two structures shows that the extra alanine moves a methionine (M221) out of its normal position, where it forms a bridge over the top of the active site. This single amino acid insertion also lengthens the beta 5- beta 6 loop, moving the entire backbone of this region further away from the active site. A model of ceftazidime bound in the active site reveals that these two structural alterations are both likely to relieve steric clashes between the bulky R1 side chain of ceftazidime and OXA-23. With activity against all four classes of beta -lactam antibiotics, OXA-146 represents an alarming new threat to the treatment of infections caused by Acinetobacter spp. JF - Antimicrobial Agents & Chemotherapy AU - Kaitany, Kip-Chumba J AU - Klinger, Neil V AU - June, Cynthia M AU - Ramey, Maddison E AU - Bonomo, Robert A AU - Powers, Rachel A AU - Leonard, David A Y1 - 2013/10// PY - 2013 DA - Oct 2013 SP - 4848 EP - 4855 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 57 IS - 10 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cephalosporins KW - Aztreonam KW - Cefotaxime KW - Amino acids KW - beta -Lactamase KW - Alanine KW - Carbapenems KW - Enzymes KW - Ampicillin KW - carbapenemase KW - Ceftriaxone KW - Infection KW - Methionine KW - Models KW - Imipenem KW - Ceftazidime KW - Acinetobacter KW - Ionizing radiation KW - beta -Lactam antibiotics KW - Crystal structure KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1443377708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Structures+of+the+Class+D+Carbapenemases+OXA-23+and+OXA-146%3A+Mechanistic+Basis+of+Activity+against+Carbapenems%2C+Extended-Spectrum+Cephalosporins%2C+and+Aztreonam&rft.au=Kaitany%2C+Kip-Chumba+J%3BKlinger%2C+Neil+V%3BJune%2C+Cynthia+M%3BRamey%2C+Maddison+E%3BBonomo%2C+Robert+A%3BPowers%2C+Rachel+A%3BLeonard%2C+David+A&rft.aulast=Kaitany&rft.aufirst=Kip-Chumba&rft.date=2013-10-01&rft.volume=57&rft.issue=10&rft.spage=4848&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00762-13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Number of references - 43 N1 - Last updated - 2013-10-21 N1 - SubjectsTermNotLitGenreText - Aztreonam; Cephalosporins; beta -Lactamase; Amino acids; Cefotaxime; Alanine; Ampicillin; Enzymes; Carbapenems; carbapenemase; Ceftriaxone; Infection; Methionine; Imipenem; Models; Ceftazidime; Ionizing radiation; beta -Lactam antibiotics; Crystal structure; Acinetobacter DO - http://dx.doi.org/10.1128/AAC.00762-13 ER - TY - JOUR T1 - Targeted opioid receptor antagonists in the treatment of alcohol use disorders. AN - 1437577785; 23881605 AB - In 1994, the US Food and Drug Administration approved the μ-opioid receptor antagonist naltrexone to treat alcohol dependence. However, treatments requiring daily administration, such as naltrexone, are inconsistently adhered to in substance abusing populations, and constant medication exposure can increase risk of adverse outcomes, e.g., hepatotoxicity. This has fostered a 'targeted' or 'as needed' approach to opioid receptor antagonist treatment, in which medications are used only in anticipation of or during high-risk situations, including times of intense cravings. Initial studies of the ability of targeted naltrexone to reduce drinking-related outcomes were conducted in problem drinkers and have been extended into larger, multi-site, placebo-controlled investigations with positive results. Another μ-opioid receptor antagonist, nalmefene, has been studied on an 'as-needed' basis to reduce heavy drinking in alcohol-dependent individuals. These studies include three large multi-site trials in Europe of up to 1 year in duration, and serve as the basis for the recent approval of nalmefene by the European Medicines Agency as an 'as-needed' adjunctive treatment for alcohol dependence. We review potential moderators of opioid receptor antagonist treatment response including subjective assessments, objective clinical measures and genetic variants. In sum, the targeted or 'as-needed' approach to treatment with opioid antagonists is an efficacious harm-reduction strategy for problem drinking and alcohol dependence. JF - CNS drugs AU - Niciu, Mark J AU - Arias, Albert J AD - VA Connecticut Health Care System/West Haven Veterans Administration Medical Center, 950 Campbell Ave., Office 116-A, West Haven, CT, 06516, USA. Y1 - 2013/10// PY - 2013 DA - October 2013 SP - 777 EP - 787 VL - 27 IS - 10 KW - Narcotic Antagonists KW - 0 KW - Receptors, Opioid KW - Naltrexone KW - 5S6W795CQM KW - nalmefene KW - TOV02TDP9I KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Molecular Targeted Therapy KW - Clinical Trials as Topic KW - Receptors, Opioid -- genetics KW - Narcotic Antagonists -- administration & dosage KW - Naltrexone -- administration & dosage KW - Alcohol-Related Disorders -- drug therapy KW - Narcotic Antagonists -- therapeutic use KW - Narcotic Antagonists -- adverse effects KW - Naltrexone -- adverse effects KW - Alcohol-Related Disorders -- metabolism KW - Naltrexone -- analogs & derivatives KW - Naltrexone -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1437577785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CNS+drugs&rft.atitle=Targeted+opioid+receptor+antagonists+in+the+treatment+of+alcohol+use+disorders.&rft.au=Niciu%2C+Mark+J%3BArias%2C+Albert+J&rft.aulast=Niciu&rft.aufirst=Mark&rft.date=2013-10-01&rft.volume=27&rft.issue=10&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=CNS+drugs&rft.issn=1179-1934&rft_id=info:doi/10.1007%2Fs40263-013-0096-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-04-14 N1 - Date created - 2013-09-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Neuropsychopharmacology. 2003 Aug;28(8):1546-52 [12813472] Alcohol. 2012 Sep;46(6):511-7 [22717196] J Consult Clin Psychol. 2004 Apr;72(2):317-27 [15065964] CNS Drugs. 2004;18(8):485-504 [15182219] J Clin Psychopharmacol. 2004 Aug;24(4):421-8 [15232334] Alcohol Clin Exp Res. 2004 Jul;28(7):1051-9 [15252291] Alcohol Clin Exp Res. 2004 Sep;28(9):1362-70 [15365307] Methods Find Exp Clin Pharmacol. 1985 Apr;7(4):175-7 [2991678] Clin Pharmacol Ther. 1986 Jan;39(1):49-53 [3943269] J Clin Pharmacol. 1987 Mar;27(3):233-9 [3680580] J Pharmacol Exp Ther. 1994 Dec;271(3):1630-7 [7996478] Alcohol Clin Exp Res. 1994 Oct;18(5):1162-7 [7847600] Clin Pharmacol Ther. 1997 Jan;61(1):15-23 [9024170] Addict Behav. 1997 May-Jun;22(3):431-6 [9183513] Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9608-13 [9689128] Alcohol Clin Exp Res. 1998 Oct;22(7):1430-6 [9802524] Arch Gen Psychiatry. 1999 Aug;56(8):719-24 [10435606] Arch Gen Psychiatry. 2005 Jan;62(1):57-64 [15630073] JAMA. 2005 Apr 6;293(13):1617-25 [15811981] Alcohol Alcohol. 2005 May-Jun;40(3):227-33 [15797885] Neuropsychopharmacology. 2005 Dec;30(12):2245-53 [15956985] Neuropsychopharmacology. 2005 Dec;30(12):2254-62 [15988468] Addict Biol. 2013 Jan;18(1):193-201 [22784013] Biol Psychiatry. 2013 Apr 15;73(8):706-13 [23237314] Eur Neuropsychopharmacol. 2013 Nov;23(11):1432-42 [23562264] Eur Neuropsychopharmacol. 2009 Oct;19(10):740-8 [19595579] Alcohol Clin Exp Res. 2000 Oct;24(10):1542-9 [11045863] J Clin Psychopharmacol. 2001 Jun;21(3):287-92 [11386491] Am J Addict. 2001 Summer;10(3):258-68 [11579624] Alcohol Clin Exp Res. 2001 Sep;25(9):1335-41 [11584154] Neuropsychopharmacology. 2003 Apr;28(4):755-64 [12655322] J Clin Psychopharmacol. 2003 Jun;23(3):294-304 [12826991] Alcohol Clin Exp Res. 2006 May;30(5):860-5 [16634855] JAMA. 2006 May 3;295(17):2003-17 [16670409] J Psychiatr Pract. 2006 Mar;12(2):80-9 [16728904] Alcohol Clin Exp Res. 2007 Apr;31(4):625-34 [17374042] Biol Psychiatry. 2007 Jun 1;61(11):1290-5 [17224132] Exp Clin Psychopharmacol. 2007 Jun;15(3):272-81 [17563214] Alcohol Clin Exp Res. 2007 Jul;31(7):1179-87 [17451401] Biol Psychiatry. 2007 Sep 15;62(6):694-7 [17336941] Biochem Pharmacol. 2008 Jan 1;75(1):34-56 [17880925] Alcohol Alcohol. 2008 Jan-Feb;43(1):53-61 [17965444] Neuropsychopharmacology. 2008 Feb;33(3):653-65 [17487229] Arch Gen Psychiatry. 2008 Feb;65(2):135-44 [18250251] Drug Alcohol Depend. 2008 May 1;95(1-2):62-72 [18243584] Alcohol Clin Exp Res. 2008 May;32(5):771-6 [18336635] Drug Alcohol Depend. 2008 Jun 1;95(3):230-6 [18329827] Alcohol Clin Exp Res. 2008 Jul;32(7):1159-66 [18537939] J Stud Alcohol Drugs. 2008 Nov;69(6):878-84 [18925346] Alcohol Alcohol. 2009 May-Jun;44(3):293-300 [19189996] J Clin Psychopharmacol. 2009 Aug;29(4):350-7 [19593174] Life Sci. 2010 Apr 10;86(15-16):624-30 [20159022] Alcohol Clin Exp Res. 2010 Oct;34(10):1803-12 [20645934] J Stud Alcohol Drugs. 2011 Jan;72(1):135-40 [21138720] Cochrane Database Syst Rev. 2010;(12):CD001867 [21154349] Alcohol Alcohol. 2011 May-Jun;46(3):308-11 [21266377] Alcohol Clin Exp Res. 2011 Jun;35(6):1134-41 [21410481] Neuropharmacology. 2011 Jul-Aug;61(1-2):35-42 [21338616] Clin Drug Investig. 2011 Nov 1;31(11):799-811 [21967071] Alcohol Res Health. 2011;34(2):257-60 [22330226] Addict Biol. 2012 May;17(3):634-47 [22515275] CNS Drugs. 2012 Jun 1;26(6):461-76 [22587755] Am J Addict. 2003 Jul-Sep;12(4):281-94 [14504021] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s40263-013-0096-4 ER - TY - JOUR T1 - Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin. AN - 1443390450; 23775962 AB - Amplifications and mutations in the KIT proto-oncogene in subsets of melanomas provide therapeutic opportunities. We conducted a multicenter phase II trial of imatinib in metastatic mucosal, acral, or chronically sun-damaged (CSD) melanoma with KIT amplifications and/or mutations. Patients received imatinib 400 mg once per day or 400 mg twice per day if there was no initial response. Dose reductions were permitted for treatment-related toxicities. Additional oncogene mutation screening was performed by mass spectroscopy. Twenty-five patients were enrolled (24 evaluable). Eight patients (33%) had tumors with KIT mutations, 11 (46%) with KIT amplifications, and five (21%) with both. Median follow-up was 10.6 months (range, 3.7 to 27.1 months). Best overall response rate (BORR) was 29% (21% excluding nonconfirmed responses) with a two-stage 95% CI of 13% to 51%. BORR was significantly greater than the hypothesized null of 5% and statistically significantly different by mutation status (7 of 13 or 54% KIT mutated v 0% KIT amplified only). There were no statistical differences in rates of progression or survival by mutation status or by melanoma site. The overall disease control rate was 50% but varied significantly by KIT mutation status (77% mutated v 18% amplified). Four patients harbored pretreatment NRAS mutations, and one patient acquired increased KIT amplification after treatment. Melanomas that arise on mucosal, acral, or CSD skin should be assessed for KIT mutations. Imatinib can be effective when tumors harbor KIT mutations, but not if KIT is amplified only. NRAS mutations and KIT copy number gain may be mechanisms of therapeutic resistance to imatinib. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Hodi, F Stephen AU - Corless, Christopher L AU - Giobbie-Hurder, Anita AU - Fletcher, Jonathan A AU - Zhu, Meijun AU - Marino-Enriquez, Adrian AU - Friedlander, Philip AU - Gonzalez, Rene AU - Weber, Jeffrey S AU - Gajewski, Thomas F AU - O'Day, Steven J AU - Kim, Kevin B AU - Lawrence, Donald AU - Flaherty, Keith T AU - Luke, Jason J AU - Collichio, Frances A AU - Ernstoff, Marc S AU - Heinrich, Michael C AU - Beadling, Carol AU - Zukotynski, Katherine A AU - Yap, Jeffrey T AU - Van den Abbeele, Annick D AU - Demetri, George D AU - Fisher, David E AD - F. Stephen Hodi, Anita Giobbie-Hurder, Philip Friedlander, Jason J. Luke, Katherine A. Zukotynski, Jeffrey T. Yap, Annick D. Van den Abbeele, and George D. Demetri, Dana-Farber Cancer Institute; Jonathan A. Fletcher, Meijun Zhu, and Adrian Marino-Enriquez, Brigham and Women's Hospital; Donald Lawrence, Keith T. Flaherty, and David E. Fisher, Massachusetts General Hospital, Boston, MA; Christopher L. Corless, Michael C. Heinrich, and Carol Beadling, Portland Veterans Administration Medical Center and Oregon Health & Science University, Portland, OR; Philip Friedlander, Mount Sinai Medical Center, New York, NY; Rene Gonzalez, University of Colorado Cancer Center, Aurora, CO; Jeffrey S. Weber, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Thomas F. Gajewski, University of Chicago, Chicago, IL; Steven J. O'Day, Beverly Hills Cancer Center, Beverly Hills, CA; Kevin B. Kim, The University of Texas MD Anderson Cancer Center, Houston, TX; Frances A. Collichio, The University of North Carolina at Chapel Hill, Chapel Hill, NC; and Marc S. Ernstoff, Geisel School of Medicine and Norris Cotton Cancer Center, Hanover, NH. Y1 - 2013/09/10/ PY - 2013 DA - 2013 Sep 10 SP - 3182 EP - 3190 VL - 31 IS - 26 KW - Antineoplastic Agents KW - 0 KW - Benzamides KW - Biomarkers, Tumor KW - Membrane Proteins KW - Piperazines KW - Pyrimidines KW - Imatinib Mesylate KW - 8A1O1M485B KW - Proto-Oncogene Proteins c-kit KW - EC 2.7.10.1 KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - NRAS protein, human KW - Index Medicus KW - Biomarkers, Tumor -- genetics KW - Humans KW - Prognosis KW - Aged KW - Membrane Proteins -- genetics KW - Survival Rate KW - Neoplasm Recurrence, Local -- drug therapy KW - GTP Phosphohydrolases -- genetics KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Chronic Disease KW - Antineoplastic Agents -- therapeutic use KW - Neoplasm Recurrence, Local -- genetics KW - Female KW - Male KW - Neoplasm Recurrence, Local -- pathology KW - Neoplasm Recurrence, Local -- mortality KW - Pyrimidines -- therapeutic use KW - Melanoma -- mortality KW - Piperazines -- therapeutic use KW - Mucous Membrane -- drug effects KW - Skin Neoplasms -- secondary KW - Gene Amplification KW - Skin Neoplasms -- genetics KW - Skin Neoplasms -- drug therapy KW - Melanoma -- pathology KW - Melanoma -- genetics KW - Melanoma -- drug therapy KW - Sunlight KW - Mutation -- genetics KW - Mucous Membrane -- pathology KW - Proto-Oncogene Proteins c-kit -- genetics KW - Skin Neoplasms -- mortality KW - Benzamides -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1443390450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Imatinib+for+melanomas+harboring+mutationally+activated+or+amplified+KIT+arising+on+mucosal%2C+acral%2C+and+chronically+sun-damaged+skin.&rft.au=Hodi%2C+F+Stephen%3BCorless%2C+Christopher+L%3BGiobbie-Hurder%2C+Anita%3BFletcher%2C+Jonathan+A%3BZhu%2C+Meijun%3BMarino-Enriquez%2C+Adrian%3BFriedlander%2C+Philip%3BGonzalez%2C+Rene%3BWeber%2C+Jeffrey+S%3BGajewski%2C+Thomas+F%3BO%27Day%2C+Steven+J%3BKim%2C+Kevin+B%3BLawrence%2C+Donald%3BFlaherty%2C+Keith+T%3BLuke%2C+Jason+J%3BCollichio%2C+Frances+A%3BErnstoff%2C+Marc+S%3BHeinrich%2C+Michael+C%3BBeadling%2C+Carol%3BZukotynski%2C+Katherine+A%3BYap%2C+Jeffrey+T%3BVan+den+Abbeele%2C+Annick+D%3BDemetri%2C+George+D%3BFisher%2C+David+E&rft.aulast=Hodi&rft.aufirst=F&rft.date=2013-09-10&rft.volume=31&rft.issue=26&rft.spage=3182&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2012.47.7836 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-11-22 N1 - Date created - 2013-09-09 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00424515; ClinicalTrials.gov N1 - SuppNotes - Comment In: J Clin Oncol. 2013 Sep 10;31(26):3173-5 [23940226] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1200/JCO.2012.47.7836 ER - TY - JOUR T1 - Adverse Impact of Coercive Treatments on Psychiatric Inpatients' Satisfaction with Care AN - 1558988882; 201432036 AB - Consumers' satisfaction with inpatient mental health care is recognized as a key quality indicator that prospectively predicts functional and clinical outcomes. Coercive treatment experience is a frequently cited source of dissatisfaction with inpatient care, yet more research is needed to understand the factors that influence consumers' perceptions of coercion and its effects on satisfaction, including potential "downstream" effects of past coercive events on current treatment satisfaction. The current study examined associations between objective and subjective indices of coercive treatments and patients' satisfaction with care in a psychiatric inpatient sample (N = 240). Lower satisfaction ratings were independently associated with three coercive treatment variables: current involuntary admission, perceived coercion during current admission, and self-reported history of being refused a requested medication. Albeit preliminary, these results document associations between patients' satisfaction ratings and their subjective experiences of coercion during both current and prior hospitalizations. Adapted from the source document. JF - Community Mental Health Journal AU - Strauss, Jennifer L AU - Zervakis, Jennifer B AU - Stechuchak, Karen M AU - Olsen, Maren K AU - Swanson, Jeffrey AU - Swartz, Marvin S AU - Weinberger, Morris AU - Marx, Christine E AU - Calhoun, Patrick S AU - Bradford, Daniel W AU - Butterfield, Marian I AU - Oddone, Eugene Z AD - Center for Health Services Research in Primary Care, VISN 6 MIRECC, Bldg 6, 508 Fulton Street, Durham, NC, 27705, USA jennifer.strauss@va.gov Y1 - 2013/08// PY - 2013 DA - August 2013 SP - 457 EP - 465 PB - Springer, Dordrecht The Netherlands VL - 49 IS - 4 SN - 0010-3853, 0010-3853 KW - Dissatisfaction KW - Patient satisfaction KW - Hospitalization KW - Psychiatric hospitals KW - Coercion KW - Patient care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558988882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Adverse+Impact+of+Coercive+Treatments+on+Psychiatric+Inpatients%27+Satisfaction+with+Care&rft.au=Strauss%2C+Jennifer+L%3BZervakis%2C+Jennifer+B%3BStechuchak%2C+Karen+M%3BOlsen%2C+Maren+K%3BSwanson%2C+Jeffrey%3BSwartz%2C+Marvin+S%3BWeinberger%2C+Morris%3BMarx%2C+Christine+E%3BCalhoun%2C+Patrick+S%3BBradford%2C+Daniel+W%3BButterfield%2C+Marian+I%3BOddone%2C+Eugene+Z&rft.aulast=Strauss&rft.aufirst=Jennifer&rft.date=2013-08-01&rft.volume=49&rft.issue=4&rft.spage=457&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-012-9539-5 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Number of references - 42 N1 - Last updated - 2016-09-27 N1 - CODEN - CMHJAY N1 - SubjectsTermNotLitGenreText - Hospitalization; Coercion; Patient care; Patient satisfaction; Psychiatric hospitals; Dissatisfaction DO - http://dx.doi.org/10.1007/s10597-012-9539-5 ER - TY - JOUR T1 - Providing culturally competent supervision to trainees with disabilities in rehabilitation settings. AN - 1449096325; 201322665 AB - Objective: Very little is known about the supervision experiences of psychology trainees with disabilities in rehabilitation training settings. It is clear from the lack of literature, however, that a gap exists in training and education for supervisors about working with disabled trainees and providing culturally competent supervision. The purpose of this article is to explore legal and ethical concerns, cultural considerations of disability as an aspect of human diversity, attitudinal barriers, and mentorship during the professional journey of training future psychologists with disabilities. Method: This article was developed by reviewing the pertinent literature. The authors utilized a sample vignette and pertinent points from their own experiences as trainees, psychologists, and supervisors with disabilities in rehabilitation settings. Results: A thorough discussion of the diversity and cultural aspects of supervising disabled trainees is included, along with a discussion of the importance of mentorship. Implications: A summary of recommendations is provided for supervisors of trainees with disabilities. [Copyright The American Psychological Association.] JF - Rehabilitation Psychology AU - Andrews, Erin E AU - Kuemmel, Angela AU - Williams, Julie L AU - Pilarski, Carrie R AU - Dunn, Michael AU - Lund, Emily M Y1 - 2013/08// PY - 2013 DA - August 2013 SP - 233 EP - 244 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 58 IS - 3 SN - 0090-5550, 0090-5550 KW - culturally competent supervision KW - discrimination KW - rehabilitation setting KW - trainees with disabilities KW - Rehabilitation KW - Trainees KW - Psychologists KW - Mentoring KW - Cultural competence KW - Supervisors KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1449096325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rehabilitation+Psychology&rft.atitle=Providing+culturally+competent+supervision+to+trainees+with+disabilities+in+rehabilitation+settings.&rft.au=Andrews%2C+Erin+E%3BKuemmel%2C+Angela%3BWilliams%2C+Julie+L%3BPilarski%2C+Carrie+R%3BDunn%2C+Michael%3BLund%2C+Emily+M&rft.aulast=Andrews&rft.aufirst=Erin&rft.date=2013-08-01&rft.volume=58&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Rehabilitation+Psychology&rft.issn=00905550&rft_id=info:doi/10.1037%2Fa0033338 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Trainees; Supervisors; Rehabilitation; Mentoring; Psychologists; Cultural competence DO - http://dx.doi.org/10.1037/a0033338 ER - TY - JOUR T1 - Predicting levels of independence with expressing needs and ideas 1 year after severe brain injury. AN - 1449096101; 201324545 AB - Purpose/Objective: Severe brain injury (BI) is a catastrophic event often evolving into a complex chronic and severely disabling condition making activity participation possible only with sustained caregiving. One aspect of building sustainable caregiving is early provision of information about expected outcomes germane to patients and their caregivers. An analysis was conducted to determine whether 2 levels of independence with expressing needs and ideas 1-year after severe BI could be predicted using variables available early after injury. Method: The authors examined a subsample (n = 79) of participants of an outcome study who received repeated neurobehavioral evaluations with the Disorders of Consciousness Scale (DOCS) and who were assessed 1 year after injury with the Functional Independence Measures (FIM). Explanatory variables included DOCS measures, patient characteristics, coexisting conditions, and interventions. The outcome is measured with the FIM Expression item. Optimal data analysis was used to construct multivariate classification tree models. Results: The 2nd (p = .004) DOCS visual measure and seizure (p = .004) entered the final model providing 79% accuracy in classifying more or less independence with expressing needs and ideas at 1 year. The model will correctly identify 78% of future severe BI survivors who will have more independence and 82% of persons who will have less independence. Conclusions: For persons incurring severe BI, it is possible to predict, early after injury, more and less independence with expressing needs and ideas 1-year after injury. This evidence is 1 contribution to a larger body of evidence needed to enable early caregiver education about recovery expectations in terms of patient functioning relative to caregiving needs, which in turn will help build sustainable caregiving for this population. [Copyright The American Psychological Association.] JF - Rehabilitation Psychology AU - Pape, Theresa Louise-Bender AU - Guernon, Ann AU - Lundgren, Sandra AU - Patil, Vijaya AU - Herrold, Amy A AU - Smith, Bridget AU - Blahnik, Melanie AU - Picon, Linda M AU - Harton, Brett AU - Peterson, Michelle AU - Mallinson, Trudy AU - Hoffmann, Michael Y1 - 2013/08// PY - 2013 DA - August 2013 SP - 253 EP - 262 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 58 IS - 3 SN - 0090-5550, 0090-5550 KW - coma KW - communication KW - minimally conscious state KW - prognoses KW - vegetative state KW - independence KW - needs KW - ideas KW - severe brain injury KW - Seizure KW - Classification KW - Injuries KW - Brain injuries KW - Survivors KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1449096101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rehabilitation+Psychology&rft.atitle=Predicting+levels+of+independence+with+expressing+needs+and+ideas+1+year+after+severe+brain+injury.&rft.au=Pape%2C+Theresa+Louise-Bender%3BGuernon%2C+Ann%3BLundgren%2C+Sandra%3BPatil%2C+Vijaya%3BHerrold%2C+Amy+A%3BSmith%2C+Bridget%3BBlahnik%2C+Melanie%3BPicon%2C+Linda+M%3BHarton%2C+Brett%3BPeterson%2C+Michelle%3BMallinson%2C+Trudy%3BHoffmann%2C+Michael&rft.aulast=Pape&rft.aufirst=Theresa&rft.date=2013-08-01&rft.volume=58&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Rehabilitation+Psychology&rft.issn=00905550&rft_id=info:doi/10.1037%2Fa0032610 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Carers; Injuries; Brain injuries; Classification; Seizure; Survivors DO - http://dx.doi.org/10.1037/a0032610 ER - TY - JOUR T1 - Telephone-delivered cognitive-behavioral therapy for pain management among older military veterans: A randomized trial AN - 1438663667; 201320570 AB - [Correction Notice: An Erratum for this article was reported in Vol 10(3) of Psychological Services (see record 2013-28609-001). In the article "Telephone-Delivered Cognitive-ehavioral Therapy for Pain Management Among Older Military Veterans: A Randomized Trial" by Timothy P. Carmody, Carol L. Duncan, Joy Huggins, Sharon N. Solkowitz, Sharon K. Lee, Norma Reyes, Sharon Mozgai, and Joel A. Simon (Psychological Services, Advance Online Publication, Dec 17, 2012, np), the copyright attribution was incorrect. The article is in the public domain. All versions of this article have been corrected.] This study investigated the effectiveness of telephone-delivered cognitive-behavioral therapy (T-CBT) in the management of chronic pain with older military veterans enrolled in VA primary-care clinics. We conducted a randomized clinical trial comparing T-CBT with telephone-delivered pain education (T-EDU). A total of 98 military veterans with chronic pain were enrolled in the study and randomized into one of two treatment conditions. Study participants were recruited from primary-care clinics at an urban VA medical center and affiliated VA community-based outpatient clinics (CBOCs). Pain management outcomes were measured at midtreatment (10 weeks), posttreatment (20 weeks), 3-month follow-up (32 weeks), and 6-month follow-up (46 weeks). No significant differences were found between the two treatment groups on any of the outcome measures. Both treatment groups reported small but significant increases in level of physical and mental health, and reductions in pain and depressive symptoms. Improvements in all primary outcome measures were mediated by reductions in catastrophizing. Telephone-delivered CBT and EDU warrant further study as easily accessible interventions for rural-living older individuals with chronic pain. [Copyright Elsevier B.V.] JF - Psychological Services AU - Carmody, Timothy P AU - Duncan, Carol L AU - Huggins, Joy AU - Solkowitz, Sharon N AU - Lee, Sharon K AU - Reyes, Norma AU - Mozgai, Sharon AU - Simon, Joel A Y1 - 2013/08// PY - 2013 DA - August 2013 SP - 265 EP - 275 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 10 IS - 3 SN - 1541-1559, 1541-1559 KW - chronic pain KW - cognitive-behavioral therapy KW - pain KW - pain management KW - telemental health KW - military veterans KW - effectiveness KW - Veterans KW - Cognitive behaviour therapy KW - Psychological services KW - Chronic pain KW - Primary health care KW - Clinics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438663667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Telephone-delivered+cognitive-behavioral+therapy+for+pain+management+among+older+military+veterans%3A+A+randomized+trial&rft.au=Carmody%2C+Timothy+P%3BDuncan%2C+Carol+L%3BHuggins%2C+Joy%3BSolkowitz%2C+Sharon+N%3BLee%2C+Sharon+K%3BReyes%2C+Norma%3BMozgai%2C+Sharon%3BSimon%2C+Joel+A&rft.aulast=Carmody&rft.aufirst=Timothy&rft.date=2013-08-01&rft.volume=10&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0030944 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Chronic pain; Veterans; Cognitive behaviour therapy; Clinics; Psychological services; Primary health care DO - http://dx.doi.org/10.1037/a0030944 ER - TY - JOUR T1 - Application of the health belief model: Development of the hearing beliefs questionnaire (HBQ) and its associations with hearing health behaviors AN - 1430189025; 201319496 AB - Objective: To develop a hearing beliefs questionnaire (HBQ) that assesses hearing beliefs within the constructs of the health belief model, and to investigate whether HBQ scores are associated with hearing health behaviors. Design: A 60-item version of the questionnaire was developed and completed by 223 participants who also provided information about their hearing health behaviors (help seeking, hearing-aid acquisition, and hearing-aid use). Study sample: Individuals aged between 22 and 90 years recruited from a primary care waiting area at a Veterans hospital. Seventy-six percent were male, 80% were Veterans. Results: A 26-item version of the HBQ with six scales was derived using factor analysis and reliability analyses. The scales measured: perceived susceptibility, perceived severity, perceived benefits, perceived barriers, perceived self-efficacy, and cues to action. HBQ scores differed significantly between individuals with different hearing health behaviors. Logistic regression analyses resulted in robust models of hearing health behaviors that correctly classified between 59% and 100% of participant hearing health behaviors. Conclusions: The HBM appears to be an appropriate framework for examining hearing health behaviors, and the HBQ is a valuable tool for assessing hearing health beliefs and predicting hearing health behaviors. Adapted from the source document. JF - International Journal of Audiology AU - Saunders, Gabrielle H AU - Frederick, Melissa Teahen AU - Silverman, Shienpei AU - Papesh, Melissa AD - Department of Otolaryngology, Oregon Health and Science University, Portland, Oregon, USA gabrielle.saunders@va.gov Y1 - 2013/08// PY - 2013 DA - August 2013 SP - 558 EP - 567 PB - Informa Healthcare, Taylor and Francis, London UK VL - 52 IS - 8 SN - 1499-2027, 1499-2027 KW - Rehabilitation of hearing impaired, health behavior, health care seeking behavior, patient acceptance of health care, patient compliance, hearing aids KW - Veterans KW - Reliability KW - Health belief model KW - Hearing KW - Hospitals KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1430189025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=Application+of+the+health+belief+model%3A+Development+of+the+hearing+beliefs+questionnaire+%28HBQ%29+and+its+associations+with+hearing+health+behaviors&rft.au=Saunders%2C+Gabrielle+H%3BFrederick%2C+Melissa+Teahen%3BSilverman%2C+Shienpei%3BPapesh%2C+Melissa&rft.aulast=Saunders&rft.aufirst=Gabrielle&rft.date=2013-08-01&rft.volume=52&rft.issue=8&rft.spage=558&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/10.3109%2F14992027.2013.791030 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-09-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hearing; Health behaviour; Veterans; Health belief model; Hospitals; Reliability DO - http://dx.doi.org/10.3109/14992027.2013.791030 ER - TY - JOUR T1 - Synchronous and metachronous malignancies: analysis of the Minneapolis Veterans Affairs (VA) tumor registry AN - 1419364928; 18267362 AB - Purpose: Multiple primary malignancies (MPMs) are increasing as cancer survivorship improves. A large analysis of the SEER database estimates that approximately 16 % of new cancers reported to their registry represent a second or higher order malignancy. The purpose of this study is to estimate the number of MPM diagnoses and to define differences in synchronous and metachronous cancers in the Veterans Affairs (VA) population. Methods: The primary objective of this study was to determine the proportion of second or higher order cancers diagnosed at the Minneapolis VA Medical Center from 1 January 2005 to 31 December 2009. The secondary objectives were to analyze and compare correlative demographic, exposure, clinical, and tumor data among those with synchronous and metachronous malignancies. We included any patient with a diagnosis of a malignant cancer during the study period. Result: A total of 4,449 patients were diagnosed with malignancies during the study period. Of these, 506 patients (11.4 % of cancer diagnoses) had a diagnosis of a second or higher order malignancy. Of the 506 patients, 124 (24.3 %) had synchronous malignancies and 383 (75.5 %) had metachronous malignancies. The most common malignancy pairing was prostate cancer with bladder/ureter cancer (12 %) of MPM diagnoses. Differences between patients with synchronous and metachronous second occurrences were identified. Conclusion: Multiple primary malignancies are a growing area of interest in cancer survivorship. At our institution, approximately 1 in 9 new cancer diagnoses during the 5-year study period represented second-order malignancies. Our data suggest that the VA population is at risk of developing second primary cancers. Further analysis of this population to identify unique risk factors is warranted. JF - Cancer Causes & Control AU - Powell, Steven AU - Tarchand, Gobind AU - Rector, Thomas AU - Klein, Mark AD - Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA, mark.klein2@va.gov Y1 - 2013/08// PY - 2013 DA - Aug 2013 SP - 1565 EP - 1573 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 24 IS - 8 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Demography KW - USA, Minnesota, Minneapolis KW - Prostate cancer KW - Urinary bladder KW - Risk factors KW - Tumors KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1419364928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Synchronous+and+metachronous+malignancies%3A+analysis+of+the+Minneapolis+Veterans+Affairs+%28VA%29+tumor+registry&rft.au=Powell%2C+Steven%3BTarchand%2C+Gobind%3BRector%2C+Thomas%3BKlein%2C+Mark&rft.aulast=Powell&rft.aufirst=Steven&rft.date=2013-08-01&rft.volume=24&rft.issue=8&rft.spage=1565&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-013-0233-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-08-01 N1 - Number of references - 23 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Demography; Prostate cancer; Urinary bladder; Risk factors; Tumors; Cancer; USA, Minnesota, Minneapolis DO - http://dx.doi.org/10.1007/s10552-013-0233-x ER - TY - JOUR T1 - The Use of Self-Disclosure: Lived Experiences of Recovering Substance Abuse Counselors AN - 1494299343; 201400607 AB - This phenomenological investigation explored the lived experiences of recovering substance abuse counselors regarding their use of self-disclosure of their personal histories of addiction with clients in counseling for substance abuse-related issues. A total of 10 recovering counselors were interviewed and asked to describe in detail their uses of self-disclosure, changes in frequencies, amount, and rationale for use or nonuse of self-disclosure. The interviews were analyzed for patterns in recovering counselors' lived experiences related to self-disclosure, and themes related to rationale for and against the use of self-disclosure, benefits, and drawbacks of self-disclosure were identified. Adapted from the source document. JF - Alcoholism Treatment Quarterly AU - Ham, Carson C AU - LeMasson, Kai Dawn Stauffer AU - Hayes, Jeffrey A AD - Counseling Psychology Program, The Pennsylvania State University, University Park, Pennsylvania, USA carson.ham@va.gov Y1 - 2013/07// PY - 2013 DA - July 2013 SP - 348 EP - 374 PB - Haworth/Taylor & Francis Group, Philadephia, PA VL - 31 IS - 3 SN - 0734-7324, 0734-7324 KW - Self Disclosure KW - Substance Abuse KW - Addiction KW - Counseling KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1494299343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism+Treatment+Quarterly&rft.atitle=The+Use+of+Self-Disclosure%3A+Lived+Experiences+of+Recovering+Substance+Abuse+Counselors&rft.au=Ham%2C+Carson+C%3BLeMasson%2C+Kai+Dawn+Stauffer%3BHayes%2C+Jeffrey+A&rft.aulast=Ham&rft.aufirst=Carson&rft.date=2013-07-01&rft.volume=31&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Alcoholism+Treatment+Quarterly&rft.issn=07347324&rft_id=info:doi/10.1080%2F07347324.2013.800399 LA - English DB - Social Services Abstracts N1 - Date revised - 2014-02-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ATQUE7 N1 - SubjectsTermNotLitGenreText - Self Disclosure; Counseling; Substance Abuse; Addiction DO - http://dx.doi.org/10.1080/07347324.2013.800399 ER - TY - JOUR T1 - Pathways and Barriers to Care for LGBT Veterans in the U.S. Department of Veterans Affairs (VA) AN - 1494299217; 201401129 AB - To assess the perceived needs of lesbian, gay, bisexual, and transgender (LGBT) Veterans when they engage in counseling services through the Veterans' Health Administration (VHA), psychologists working in VHA were reached through an online survey as well as an open-ended question that asked psychologists to offer their thoughts about the needs of LGBT Veterans in VHA and current VHA resources. Their answers were content analyzed to determine what lessons can be learned from their experiences with LGBT Veterans in the VHA system. Four major themes emerged: Concern about the current culture of the medical facilities as a whole (Veterans, staff, environment), concern for the safeguarding of privacy and dignity of clients through the electronic medical record when writing counseling progress notes, need for training of counselors, and need for resources for counselors and Veterans. Adapted from the source document. JF - Journal of LGBT Issues in Counseling AU - Johnson, Laura AU - Federman, Edward J AD - Edith Nourse Rogers Memorial Veterans Hospital, Bedford, Massachusetts, USA laura.johnson9@va.gov Y1 - 2013/07// PY - 2013 DA - July 2013 SP - 218 EP - 235 PB - Taylor & Francis, Abingdon UK VL - 7 IS - 3 SN - 1553-8605, 1553-8605 KW - Veterans KW - Human Dignity KW - Bisexuality KW - Sex Role Identity KW - Psychologists KW - Health Behavior KW - Homosexuality KW - Counseling KW - Internet KW - article KW - 6148: problems of minority groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1494299217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+LGBT+Issues+in+Counseling&rft.atitle=Pathways+and+Barriers+to+Care+for+LGBT+Veterans+in+the+U.S.+Department+of+Veterans+Affairs+%28VA%29&rft.au=Johnson%2C+Laura%3BFederman%2C+Edward+J&rft.aulast=Johnson&rft.aufirst=Laura&rft.date=2013-07-01&rft.volume=7&rft.issue=3&rft.spage=218&rft.isbn=&rft.btitle=&rft.title=Journal+of+LGBT+Issues+in+Counseling&rft.issn=15538605&rft_id=info:doi/10.1080%2F15538605.2013.812928 L2 - http://www.tandfonline.com/loi/wlco20#.Ug5ySmdH2ZQ LA - English DB - Social Services Abstracts N1 - Date revised - 2014-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Veterans; Counseling; Sex Role Identity; Psychologists; Bisexuality; Health Behavior; Homosexuality; Human Dignity; Internet DO - http://dx.doi.org/10.1080/15538605.2013.812928 ER - TY - JOUR T1 - Nursing Student Attitudes Toward and Preferences for Working With Older Adults AN - 1463034232; 201309271 AB - A growing aging population will require nurses who prefer to work with older adults. Schools of nursing have used several strategies to improve students' attitudes, and encourage preferences for working with older adults. However, research on these strategies is inconsistent, with some programs improving students' attitudes whereas others have no effect. More recent studies have found that although attitudes have improved, working with older adults is generally the least preferred area of nursing. The purpose of this longitudinal mixed methods study is to describe and explain student nurse attitudes and preference changes over time. Eighty undergraduate nursing students were surveyed over 2 years. Students' attitudes and preference for working with older adults improved over time. However, their preference to work in nursing homes was consistently ranked last among the 10 choices for work preferences. In focus groups, students reported that the gerontological course dispelled myths about caring for older adults, and that clinical placement played a major role in influencing student work preferences. Adapted from the source document. JF - Gerontology & Geriatrics Education AU - King, Barbara J AU - Roberts, Tonya J AU - Bowers, Barbara J AD - William S. Middleton Memorial Veterans Administration Hospital, Madison, Wisconsin, USA bjking2@wisc.edu Y1 - 2013/07// PY - 2013 DA - July 2013 SP - 272 EP - 291 PB - Taylor & Francis, Philadelphia PA VL - 34 IS - 3 SN - 0270-1960, 0270-1960 KW - Attitudes KW - Student Attitudes KW - Aging KW - Nurses KW - Elderly KW - College Students KW - Students KW - Placement KW - Nursing Homes KW - article KW - 6113: social work education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463034232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gerontology+%26+Geriatrics+Education&rft.atitle=Nursing+Student+Attitudes+Toward+and+Preferences+for+Working+With+Older+Adults&rft.au=King%2C+Barbara+J%3BRoberts%2C+Tonya+J%3BBowers%2C+Barbara+J&rft.aulast=King&rft.aufirst=Barbara&rft.date=2013-07-01&rft.volume=34&rft.issue=3&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Gerontology+%26+Geriatrics+Education&rft.issn=02701960&rft_id=info:doi/10.1080%2F02701960.2012.718012 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - GGEDD6 N1 - SubjectsTermNotLitGenreText - Elderly; Student Attitudes; Nurses; Students; Nursing Homes; College Students; Attitudes; Placement; Aging DO - http://dx.doi.org/10.1080/02701960.2012.718012 ER - TY - JOUR T1 - Lasting Impact: Understanding the Psychosocial Implications of Cancer Among Military Veterans AN - 1463025217; 201309298 AB - This qualitative study aimed to identify Veterans' perceptions of how cancer affects their life following treatment, particularly in relation to treatment side effects and identity as a cancer survivor. A diverse sample of 35 Veteran cancer survivors participated in semistructured, individual interviews. Thematic analysis revealed the enduring impact of diagnosis and chronic uncertainty regarding recurrence, psychological side effects that were periodic and typically self-managed, and physical side effects as common, but considered an acceptable trade-off for increased chances of survival. Perceptions of the term cancer survivor varied considerably among participants. Implications for survivorship wellness and care planning are discussed. Adapted from the source document. JF - Journal of Psychosocial Oncology AU - Beehler, Gregory P AU - Rodrigues, Amy E AU - Kay, Morgan A AU - Kiviniemi, Marc T AU - Steinbrenner, Lynn AD - Veterans Affairs Center for Integrated Healthcare, Veterans Affairs Western New York Healthcare System, Buffalo, NY, USA gregory.beehler@va.gov Y1 - 2013/07// PY - 2013 DA - July 2013 SP - 430 EP - 450 PB - Taylor & Francis, Philadelphia PA VL - 31 IS - 4 SN - 0734-7332, 0734-7332 KW - Certainty KW - Veterans KW - Identity KW - Armed Forces KW - Cancer KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463025217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychosocial+Oncology&rft.atitle=Lasting+Impact%3A+Understanding+the+Psychosocial+Implications+of+Cancer+Among+Military+Veterans&rft.au=Beehler%2C+Gregory+P%3BRodrigues%2C+Amy+E%3BKay%2C+Morgan+A%3BKiviniemi%2C+Marc+T%3BSteinbrenner%2C+Lynn&rft.aulast=Beehler&rft.aufirst=Gregory&rft.date=2013-07-01&rft.volume=31&rft.issue=4&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychosocial+Oncology&rft.issn=07347332&rft_id=info:doi/10.1080%2F07347332.2013.798762 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JPONED N1 - SubjectsTermNotLitGenreText - Cancer; Veterans; Identity; Armed Forces; Certainty DO - http://dx.doi.org/10.1080/07347332.2013.798762 ER - TY - JOUR T1 - Anxiety Related to Nonerotic Cognitive Distractions During Sexual Activity in Lesbian, Bisexual, and Heterosexual Women AN - 1463011667; 201347114 AB - The authors recruited 25 bisexual, 25 lesbian, and 25 heterosexual college women to determine whether group differences exist in anxiety related to nonerotic cognitive distractions during sexual activity, as well as in variables contributing to the prediction of anxiety. Participants completed questionnaires assessing anxiety related to nonerotic cognitive distractions during sexual activity, as well as additional variables (e.g., religiosity and self-esteem). Bisexual women reported significantly greater disease-related anxiety than lesbians, and heterosexual women reported significantly greater anxiety pertaining to emotional/external concerns than bisexuals. In other analyses, lesbians had significantly more positive attitudes toward sex than did the bisexuals, and heterosexuals reported higher levels of religiosity than lesbians. Finally, bisexuals had higher levels of internalized heterosexism than lesbians, a level not significantly different from the level of the (by definition, noninternalized) heterosexism among the heterosexuals. Additional analyses clarified the multivariate relationships among these variables. Adapted from the source document. JF - Journal of Bisexuality AU - Lacefield, Katharine AU - Negy, Charles AU - Velezmoro, Rodrigo AD - Washington DC VA Medical Center, Washington, DC, USA katharine.lacefield2@va.gov Y1 - 2013/07// PY - 2013 DA - July 2013 SP - 390 EP - 408 PB - Taylor & Francis, Philadelphia PA VL - 13 IS - 3 SN - 1529-9716, 1529-9716 KW - Sexual Behavior KW - Lesbianism KW - Attitudes KW - Religiosity KW - Bisexuality KW - Heterosexuality KW - Females KW - Heterosexism KW - Cognition KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463011667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bisexuality&rft.atitle=Anxiety+Related+to+Nonerotic+Cognitive+Distractions+During+Sexual+Activity+in+Lesbian%2C+Bisexual%2C+and+Heterosexual+Women&rft.au=Lacefield%2C+Katharine%3BNegy%2C+Charles%3BVelezmoro%2C+Rodrigo&rft.aulast=Lacefield&rft.aufirst=Katharine&rft.date=2013-07-01&rft.volume=13&rft.issue=3&rft.spage=390&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bisexuality&rft.issn=15299716&rft_id=info:doi/10.1080%2F15299716.2013.812999 LA - English DB - Sociological Abstracts N1 - Date revised - 2013-12-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Bisexuality; Lesbianism; Heterosexuality; Females; Cognition; Sexual Behavior; Religiosity; Heterosexism; Attitudes DO - http://dx.doi.org/10.1080/15299716.2013.812999 ER - TY - JOUR T1 - An Occupational Therapist's Interdisciplinary Approach to a Geriatric Psychiatry Activity Group: A Case Study AN - 1449098881; 201323938 AB - Occupational therapy has long recognized the usefulness of activity groups to promote functional outcomes for clients in mental-health settings. An occupational therapist used an interdisciplinary approach (working with a psychiatric nurse practitioner and a manual arts therapist) to conduct a biweekly geriatric psychiatry activity group. A case study is presented to demonstrate the success and longevity of the interdisciplinary activity group. Each clinician contributed unique skills to provide occupation which provided positive outcomes for the clients. Practically, the employing of different disciplines allowed group coverage for each other in times of cost-containment and limited resources. Adapted from the source document. JF - Occupational Therapy in Mental Health AU - Kimball-Carpenter, Amy AU - Smith, Maureen AD - James A. Haley Veterans' Hospital, Tampa, Florida amy.kimball-carpenter@va.gov Y1 - 2013/07// PY - 2013 DA - July 2013 SP - 293 EP - 298 PB - Haworth/Taylor & Francis, Philadelphia PA VL - 29 IS - 3 SN - 0164-212X, 0164-212X KW - Activity groups KW - Interdisciplinary approach KW - Functional impairment KW - Geriatric psychiatry KW - Occupational therapy KW - Arts KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1449098881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+Therapy+in+Mental+Health&rft.atitle=An+Occupational+Therapist%27s+Interdisciplinary+Approach+to+a+Geriatric+Psychiatry+Activity+Group%3A+A+Case+Study&rft.au=Kimball-Carpenter%2C+Amy%3BSmith%2C+Maureen&rft.aulast=Kimball-Carpenter&rft.aufirst=Amy&rft.date=2013-07-01&rft.volume=29&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Occupational+Therapy+in+Mental+Health&rft.issn=0164212X&rft_id=info:doi/10.1080%2F0164212X.2013.819731 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Activity groups; Interdisciplinary approach; Geriatric psychiatry; Occupational therapy; Arts; Functional impairment DO - http://dx.doi.org/10.1080/0164212X.2013.819731 ER - TY - JOUR T1 - Development of a mild traumatic brain injury-specific vision screening protocol: A Delphi study AN - 1445366956; 24203539 AB - Although traumatic brain injury (TBI) can happen to anyone at any time, the wars in Iraq and Afghanistan have brought it renewed attention. Fortunately, most cases of TBI from the recent conflicts are mild TBI (mTBI). Still, many physical, psychological, and social problems are associated with mTBI. Among the difficulties encountered are oculomotor and vision problems, many of which can impede daily activities such as reading. Therefore, correct diagnosis and treatment of these mTBI-related vision problems is an important part of patient recovery. Numerous eye care providers in the Department of Veterans Affairs, in military settings, and in civilian practices specialize and are proficient in examining patients who have a history of TBI. However, many do not have this level of experience working with and treating patients with mTBI. Recognizing this, we used a modified Delphi method to derive expert opinions from a panel of 16 optometrists concerning visual examination of the patient with mTBI. This process resulted in a clinical tool containing 17 history questions and 7 examination procedures. This tool provides a set of clinical guidelines that can be used as desired by any eye care provider either as a screening tool or adjunct to a full eye examination when seeing a patient with a history of mTBI. The goal of this process was to provide optimal and uniform vision care for the patient with mTBI. [PUBLICATION ABSTRACT] JF - Journal of Rehabilitation Research and Development AU - Goodrich, Gregory L, PhD AU - Martinsen, Gary L, OD, PhD AU - Flyg, Heidi M, OD AU - Kirby, Jennine, OD AU - Asch, Steven M, MD, MPH AU - Brahm, Karen D, OD AU - Brand, John M, OD AU - Cajamarca, Diana, OD AU - Cantrell, Jenette L, OD AU - Chong, Theresa, OD AU - Dziadul, John A, OD AU - Hetrick, Barbara J, OD AU - Huang, Michael A, OD AU - Ihrig, Carolyn, OD AU - Ingalla, Shanida P, OD AU - Meltzer, Bradley R, OD AU - Rakoczy, Chrystyna M, OD AU - Rone, Ashley, OD AU - Schwartz, Elliot, OD AU - Shea, Jane E, OD Y1 - 2013 PY - 2013 DA - 2013 SP - 757 EP - 68 CY - Washington PB - Superintendent of Documents VL - 50 IS - 6 SN - 07487711 KW - Engineering KW - Studies KW - Eyes & eyesight KW - Brain damage KW - Injuries KW - Veterans KW - Brain research KW - Patients KW - Humans KW - Delphi Technique KW - Vision Disorders -- etiology KW - Vision Disorders -- diagnosis KW - Vision Tests KW - Brain Injuries -- complications KW - Medical History Taking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1445366956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Development+of+a+mild+traumatic+brain+injury-specific+vision+screening+protocol%3A+A+Delphi+study&rft.au=Goodrich%2C+Gregory+L%2C+PhD%3BMartinsen%2C+Gary+L%2C+OD%2C+PhD%3BFlyg%2C+Heidi+M%2C+OD%3BKirby%2C+Jennine%2C+OD%3BAsch%2C+Steven+M%2C+MD%2C+MPH%3BBrahm%2C+Karen+D%2C+OD%3BBrand%2C+John+M%2C+OD%3BCajamarca%2C+Diana%2C+OD%3BCantrell%2C+Jenette+L%2C+OD%3BChong%2C+Theresa%2C+OD%3BDziadul%2C+John+A%2C+OD%3BHetrick%2C+Barbara+J%2C+OD%3BHuang%2C+Michael+A%2C+OD%3BIhrig%2C+Carolyn%2C+OD%3BIngalla%2C+Shanida+P%2C+OD%3BMeltzer%2C+Bradley+R%2C+OD%3BRakoczy%2C+Chrystyna+M%2C+OD%3BRone%2C+Ashley%2C+OD%3BSchwartz%2C+Elliot%2C+OD%3BShea%2C+Jane+E%2C+OD&rft.aulast=Goodrich&rft.aufirst=Gregory&rft.date=2013-07-01&rft.volume=50&rft.issue=6&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Superintendent of Documents 2013 N1 - Document feature - Tables; References N1 - Last updated - 2014-06-12 N1 - CODEN - JRRDDB ER - TY - JOUR T1 - Effectiveness of acceptance and commitment therapy for depression: Comparison among older and younger veterans AN - 1438669480; 201321262 AB - Objectives: Limited data exist on outcomes of older adults receiving psychotherapy for depression in real-world settings. Acceptance and Commitment Therapy for depression (ACT-D) offers potential utility for older individuals who may experience issues of loss, reduced control, and other life changes. The present article examines and compares outcomes of older and younger Veterans receiving ACT-D nationally in the U.S. Department of Veterans Affairs health care system. Method: Patient outcomes were assessed using the Beck Depression Inventory-Second Edition and the World Health Organization Quality of Life-BREF. Therapeutic alliance was assessed using the Working Alliance Inventory-Short Revised. Results: Six hundred fifty-five Veterans aged 18-64 and 76 Veterans aged 65+ received ACT-D. Seventy-eight percent of older and 67% of younger patients completed all sessions or finished early. Mean depression scores declined from 28.4 (SD = 11.4) to 17.5 (SD = 12.0) in the older group and 30.3 (SD = 10.6) to 19.1 (SD = 14.3) in the younger group. Within-group effect sizes were d = .95 and d = 1.06 for the two age groups, respectively. Quality of life and therapeutic alliance also increased during treatment. Conclusion: The findings suggest that ACT-D is an effective and acceptable treatment for older Veterans treated in routine clinical settings, including those with high levels of depression. Adapted from the source document. JF - Aging & Mental Health AU - Karlin, Bradley E AU - Walser, Robyn D AU - Yesavage, Jerome AU - Zhang, Aimee AU - Trockel, Mickey AU - Taylor, C Barr AD - Mental Health Services, U.S. Department of Veterans Affairs Central Office, Washington, DC, United States bradley.karlin2@va.gov Y1 - 2013/07// PY - 2013 DA - July 2013 SP - 555 EP - 563 PB - Taylor & Francis, Abingdon UK VL - 17 IS - 5 SN - 1360-7863, 1360-7863 KW - Veterans KW - Depression KW - Acceptance KW - Life changes KW - Therapeutic alliances KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438669480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aging+%26+Mental+Health&rft.atitle=Effectiveness+of+acceptance+and+commitment+therapy+for+depression%3A+Comparison+among+older+and+younger+veterans&rft.au=Karlin%2C+Bradley+E%3BWalser%2C+Robyn+D%3BYesavage%2C+Jerome%3BZhang%2C+Aimee%3BTrockel%2C+Mickey%3BTaylor%2C+C+Barr&rft.aulast=Karlin&rft.aufirst=Bradley&rft.date=2013-07-01&rft.volume=17&rft.issue=5&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Aging+%26+Mental+Health&rft.issn=13607863&rft_id=info:doi/10.1080%2F13607863.2013.789002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AMHTFD N1 - SubjectsTermNotLitGenreText - Veterans; Depression; Therapeutic alliances; Acceptance; Quality of life; Life changes DO - http://dx.doi.org/10.1080/13607863.2013.789002 ER - TY - JOUR T1 - Does depressed mood moderate the influence of drive for thinness and muscularity on eating disorder symptoms among college men? AN - 1438664560; 201321041 AB - Research suggests men have become increasingly concerned about their bodies with respect to both thinness and muscularity, and these concerns are associated with behavioral and psychological consequences that differ from women. The current study evaluated depressed mood as a moderator of associations between drives for thinness and muscularity and eating disorder symptoms among male college students and examined whether these relationships differed from women. Participants included 669 undergraduate students (34.4% men) who completed an online survey assessing body image, depressed mood, and other health-related attitudes and behaviors. Results of negative binomial regression analyses revealed a greater risk of eating disorder symptoms among men with greater drives for thinness, muscularity, and depressed mood. Depressed mood moderated the association between drive for thinness and eating disorder symptoms in both men and women, such that the significant relationship between drive for thinness and eating disorder symptoms was stronger among those with lower levels of depressed mood. Drive for muscularity was positively associated with a greater risk of eating disorder symptoms for men with lower levels of depressed mood. These findings add to the growing literature on the relationship between depressed mood and eating disorder symptoms among college men. Given previous research in this area has primarily focused on women, future work is needed to inform screening and intervention strategies targeting college men exhibiting depressed mood and eating disorder symptoms. [Copyright The American Psychological Association.] JF - Psychology of Men & Masculinity AU - Grossbard, Joel R AU - Atkins, David C AU - Geisner, Irene M AU - Larimer, Mary E AD - Department of Psychiatry and Behavioral Sciences, University of Washington joel.grossbard@va.gov Y1 - 2013/07// PY - 2013 DA - July 2013 SP - 281 EP - 287 PB - American Psychological Association, Washington DC VL - 14 IS - 3 SN - 1524-9220, 1524-9220 KW - depressed mood KW - eating disorders KW - gender KW - muscularity KW - thinness KW - symptoms KW - Symptoms KW - Men KW - Eating disorders KW - Thinness KW - Moods KW - Body build KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438664560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Men+%26+Masculinity&rft.atitle=Does+depressed+mood+moderate+the+influence+of+drive+for+thinness+and+muscularity+on+eating+disorder+symptoms+among+college+men%3F&rft.au=Grossbard%2C+Joel+R%3BAtkins%2C+David+C%3BGeisner%2C+Irene+M%3BLarimer%2C+Mary+E&rft.aulast=Grossbard&rft.aufirst=Joel&rft.date=2013-07-01&rft.volume=14&rft.issue=3&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Men+%26+Masculinity&rft.issn=15249220&rft_id=info:doi/10.1037%2Fa0028913 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Moods; Eating disorders; Symptoms; Thinness; Men; Body build DO - http://dx.doi.org/10.1037/a0028913 ER - TY - JOUR T1 - Cognitive-Behavioral Conjoint Therapy for PTSD: Initial Findings for Operations Enduring and Iraqi Freedom Male Combat Veterans and Their Partners AN - 1438556089; 201308084 AB - Posttraumatic stress disorder (PTSD) and partner relationship difficulties commonly co-occur among Veterans of Operations Enduring Freedom and Iraqi Freedom (OEF-OIF). This study reports upon results for six male OEF-OIF Veterans with PTSD and their female relationship partners who completed cognitive-behavioral conjoint therapy for PTSD (CBCT for PTSD), which is a treatment that targets reductions in PTSD and couple distress. Case- and group-level data supported reductions in Veterans' PTSD symptoms and female partners' relationship distress. These findings suggest that CBCT for PTSD may be a promising intervention for OEF-OIF Veterans' PTSD and their partners. Adapted from the source document. JF - The American Journal of Family Therapy AU - Schumm, Jeremiah A AU - Fredman, Steffany J AU - Monson, Candice M AU - Chard, Kathleen M AD - Cincinnati VA Medical Center and University of Cincinnati, Cincinnati, Ohio, USA jeremiah.schumm@va.gov Y1 - 2013/07// PY - 2013 DA - July 2013 SP - 277 EP - 287 PB - Taylor & Francis, Philadelphia PA VL - 41 IS - 4 SN - 0192-6187, 0192-6187 KW - Couples KW - Veterans KW - Conjoint Therapy KW - Males KW - Intervention KW - Psychological Distress KW - Freedom KW - Females KW - Posttraumatic Stress Disorder KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438556089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Family+Therapy&rft.atitle=Cognitive-Behavioral+Conjoint+Therapy+for+PTSD%3A+Initial+Findings+for+Operations+Enduring+and+Iraqi+Freedom+Male+Combat+Veterans+and+Their+Partners&rft.au=Schumm%2C+Jeremiah+A%3BFredman%2C+Steffany+J%3BMonson%2C+Candice+M%3BChard%2C+Kathleen+M&rft.aulast=Schumm&rft.aufirst=Jeremiah&rft.date=2013-07-01&rft.volume=41&rft.issue=4&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Family+Therapy&rft.issn=01926187&rft_id=info:doi/10.1080%2F01926187.2012.701592 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJFTDE N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Veterans; Freedom; Males; Psychological Distress; Females; Conjoint Therapy; Intervention; Couples DO - http://dx.doi.org/10.1080/01926187.2012.701592 ER - TY - JOUR T1 - Measuring Use of Evidence Based Psychotherapy for Posttraumatic Stress Disorder AN - 1430189383; 201319606 AB - To improve methods of estimating use of evidence-based psychotherapy for posttraumatic stress disorder in the Veteran's health administration, we evaluated administrative data and note text for patients newly enrolling in six VHA outpatient PTSD clinics in New England during the 2010 fiscal year (n = 1,924). Using natural language processing, we developed machine learning algorithms that mimic human raters in classifying note text. We met our targets for algorithm performance as measured by precision, recall, and F-measure. We found that 6.3 % of our study population received at least one session of evidence-based psychotherapy during the initial 6 months of treatment. Evidence-based psychotherapies appear to be infrequently utilized in VHA outpatient PTSD clinics in New England. Our method could support efforts to improve use of these treatments. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - Shiner, Brian AU - D'Avolio, Leonard W AU - Nguyen, Thien M AU - Zayed, Maha H AU - Young-Xu, Yinong AU - Desai, Rani A AU - Schnurr, Paula P AU - Fiore, Louis D AU - Watts, Bradley V AD - VA Medical Center, White River Junction, VT, USA brian.shiner@va.gov Y1 - 2013/07// PY - 2013 DA - July 2013 SP - 311 EP - 318 PB - Springer, Dordrecht The Netherlands VL - 40 IS - 4 SN - 0894-587X, 0894-587X KW - Evidence based KW - Posttraumatic stress disorder KW - Psychotherapy KW - Algorithms KW - New England KW - Evidence based medicine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1430189383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Measuring+Use+of+Evidence+Based+Psychotherapy+for+Posttraumatic+Stress+Disorder&rft.au=Shiner%2C+Brian%3BD%27Avolio%2C+Leonard+W%3BNguyen%2C+Thien+M%3BZayed%2C+Maha+H%3BYoung-Xu%2C+Yinong%3BDesai%2C+Rani+A%3BSchnurr%2C+Paula+P%3BFiore%2C+Louis+D%3BWatts%2C+Bradley+V&rft.aulast=Shiner&rft.aufirst=Brian&rft.date=2013-07-01&rft.volume=40&rft.issue=4&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-012-0421-0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Psychotherapy; Evidence based; New England; Algorithms; Evidence based medicine DO - http://dx.doi.org/10.1007/s10488-012-0421-0 ER - TY - JOUR T1 - Predictors of Substance Abuse Treatment Outcome in Hospitalized Veterans AN - 1430188401; 201319958 AB - Background and Objectives: Historically patients consulted for the substance abuse treatment from the medical surgical floors have a very low show rate for the substance abuse treatment. The authors performed retrospective chart review to find predictors of substance abuse treatment outcome in hospitalized veterans at Atlanta VA Medical Center. Methods: The medical records from all the patients who were admitted to the medical/surgical floor with substance abuse consults from January-December 2009 were reviewed. A total of 235 consults were received. Those records were examined to find the predictors for substance abuse treatment. Results: Multiple variables were tested for significance -- patient demographics, housing status, employment, reason for hospitalization, toxicology screens, co-morbid psychiatric and medical conditions, physician visits, and patients on waiting list. All variables were given cut-off point for the p-value of .10. These variables were then included in the logistic regression model. It was found that homelessness (2 = 16.14 and p < .0001) was the only individual variable that showed a statistically significant correlation with starting the program. It was found that homelessness (2 = 19.21 and p <.0001) was the only individual variable that showed statistically significant correlation with completing the program. Conclusions and Scientific Significance: Our study supports that for veterans with substance abuse, housing was the only consistent predictor to enter intensive outpatient program (IOP), complete IOP, and start aftercare. Our study demonstrates the need for and potential benefit of providing stable housing for the homeless veterans. Adapted from the source document. JF - The American Journal on Addictions AU - Vayalapalli, Sreedevi AU - Fareed, Ayman AU - Byrd-Sellers, Johnita AU - Stout, Steven AU - Casarella, Jennifer AU - Drexler, Karen AD - Atlanta VA Medical Center, SATP (116A), 1670 Clairmont Road, Decatur, GA 30033 sreedevi.vayalapalli2@va.gov Y1 - 2013/07// PY - 2013 DA - July 2013 SP - 358 EP - 365 PB - Wiley Subscription Services, Inc. VL - 22 IS - 4 SN - 1055-0496, 1055-0496 KW - Clinical outcomes KW - Veterans KW - Housing KW - Hospitalized KW - Substance abuse KW - Homelessness KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1430188401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+on+Addictions&rft.atitle=Predictors+of+Substance+Abuse+Treatment+Outcome+in+Hospitalized+Veterans&rft.au=Vayalapalli%2C+Sreedevi%3BFareed%2C+Ayman%3BByrd-Sellers%2C+Johnita%3BStout%2C+Steven%3BCasarella%2C+Jennifer%3BDrexler%2C+Karen&rft.aulast=Vayalapalli&rft.aufirst=Sreedevi&rft.date=2013-07-01&rft.volume=22&rft.issue=4&rft.spage=358&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+on+Addictions&rft.issn=10550496&rft_id=info:doi/10.1111%2Fj.1521-0391.2013.12050.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-09-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Substance abuse; Veterans; Housing; Homelessness; Clinical outcomes; Hospitalized DO - http://dx.doi.org/10.1111/j.1521-0391.2013.12050.x ER - TY - JOUR T1 - Predictors of Diabetes Mellitus and Abnormal Blood Glucose in Patients Receiving Opioid Maintenance Treatment AN - 1430188318; 201317681 AB - Background: Buprenorphine is a partial opioid agonist and may have less impact on the risk of developing diabetes mellitus (DM) compared to full opioid agonists like methadone. Methods: We conducted an observational retrospective study to investigate the predictable factors for impaired glucose tolerance and predisposition to DM in two groups of opiate addicts receiving long-term methadone maintenance treatment (MMT) [n = 58] or buprenorphine maintenance treatment (BMT) [n = 61]. Results: In our cohort, being African American, hepatitis C positive status, elevated AST, and ALT, and being on methadone were significantly correlated to being diagnosed with DM. Among all those factors, being on methadone was most significantly related to being diagnosed with DM (X2 = 3.9888, p-value = .0458). The BMI was the only factor that was significantly correlated to having abnormal A1c level (X2= 6.4229, p-value = .0113). Conclusions: Buprenorphine may be less likely to contribute to the development of DM than methadone. More research is needed to understand the link between opioids and DM. Adapted from the source document. JF - The American Journal on Addictions AU - Fareed, Ayman AU - Byrd-Sellers, Johnita AU - Vayalapalli, Sreedevi AU - Drexler, Karen AU - Phillips, Lawrence AD - Atlanta VA Medical Center 116A, 1670 Clairmont Rd., Decatur, GA 30033 ayman.fareed@va.gov Y1 - 2013/07// PY - 2013 DA - July 2013 SP - 411 EP - 416 PB - Wiley Subscription Services, Inc. VL - 22 IS - 4 SN - 1055-0496, 1055-0496 KW - Diabetes mellitus KW - Blood KW - Methadone KW - Buprenorphine KW - Glucose KW - Opioids KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1430188318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+on+Addictions&rft.atitle=Predictors+of+Diabetes+Mellitus+and+Abnormal+Blood+Glucose+in+Patients+Receiving+Opioid+Maintenance+Treatment&rft.au=Fareed%2C+Ayman%3BByrd-Sellers%2C+Johnita%3BVayalapalli%2C+Sreedevi%3BDrexler%2C+Karen%3BPhillips%2C+Lawrence&rft.aulast=Fareed&rft.aufirst=Ayman&rft.date=2013-07-01&rft.volume=22&rft.issue=4&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+on+Addictions&rft.issn=10550496&rft_id=info:doi/10.1111%2Fj.1521-0391.2013.12043.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-09-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Methadone; Opioids; Buprenorphine; Glucose; Diabetes mellitus; Blood DO - http://dx.doi.org/10.1111/j.1521-0391.2013.12043.x ER - TY - JOUR T1 - Body mass index patterns following dysvascular lower extremity amputation AN - 1417549304; 201316332 AB - Purpose: Using preliminary data, we examined: (i) patterns of body mass index (BMI) over the year following amputation by amputation level and (ii) the association between BMI and mobility and prosthetic device use. Method: Patients from three medical centers undergoing dysvascular amputation (N = 87; M age = 62) participated in interviews pre-surgically and at 6 weeks, 4 months, and 12 months following amputation. The main outcome was self-reported BMI, adjusting for limb weight lost due to amputation. Additional outcomes were mobility and time spent using and walking in a prosthetic device. Results: Adjusted BMI slightly decreased at 6 weeks (pre-surgery M = 31.2; 6 weeks M = 30.3) and 4 months (M = 30.7) but exceeded baseline levels by 12 months (M = 31.7). There were no significant BMI differences by amputation level. In multivariable analyses, higher pre-surgical BMI was associated with fewer hours of prosthetic device walking at month 4 (beta = -0.49) and poorer overall mobility at month 12 (beta = -0.22). Conclusions: BMI increased at one year following amputation surgery. Higher pre-surgical BMI was associated with poorer mobility and prosthetic device use. Interventions are needed to prevent excess weight gain in the year following amputation. Implications for Rehabilitation . People undergoing lower-extremity amputation have high rates of overweight and obesity and continue to gain weight in the year following amputation. . Objective assessment of body mass index (both with and without a prosthetic device) and waist circumference would help future research efforts. . Targeting weight loss post-amputation could improve the health of people with lower-extremity amputations. Adapted from the source document. JF - Disability and Rehabilitation AU - Rosenberg, Dori E AU - Turner, Aaron P AU - Littman, Alyson J AU - Williams, Rhonda M AU - Norvell, Dan C AU - Hakimi, Kevin M AU - Czerniecki, Joseph M AD - Rehabilitation Care Service, VA Puget Sound Health Care System, Seattle, WA, USA Y1 - 2013/07// PY - 2013 DA - July 2013 SP - 1269 EP - 1275 PB - Informa Healthcare, New York NY VL - 35 IS - 15 SN - 0963-8288, 0963-8288 KW - Mobility disability, obesity, prosthesis KW - Obesity KW - Mobility KW - Amputation KW - Prosthesis KW - Walking KW - Body Mass Index KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1417549304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Disability+and+Rehabilitation&rft.atitle=Body+mass+index+patterns+following+dysvascular+lower+extremity+amputation&rft.au=Rosenberg%2C+Dori+E%3BTurner%2C+Aaron+P%3BLittman%2C+Alyson+J%3BWilliams%2C+Rhonda+M%3BNorvell%2C+Dan+C%3BHakimi%2C+Kevin+M%3BCzerniecki%2C+Joseph+M&rft.aulast=Rosenberg&rft.aufirst=Dori&rft.date=2013-07-01&rft.volume=35&rft.issue=15&rft.spage=1269&rft.isbn=&rft.btitle=&rft.title=Disability+and+Rehabilitation&rft.issn=09638288&rft_id=info:doi/10.3109%2F09638288.2012.726690 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-08-01 N1 - Last updated - 2016-09-27 N1 - CODEN - DREHET N1 - SubjectsTermNotLitGenreText - Amputation; Body Mass Index; Prosthesis; Mobility; Obesity; Walking DO - http://dx.doi.org/10.3109/09638288.2012.726690 ER - TY - JOUR T1 - Impact of myocardial ischemia on myocardial revascularization in stable ischemic heart disease. Lessons from the COURAGE and FAME 2 trials TT - Einfluss der Myokardischaemie auf die myokardiale Revaskularisierung bei stabiler ischaemischer Herzkrankheit AN - 1850781435; 18154512 AB - In patients with stable ischemic heart disease (SIHD), myocardial revascularization should be performed to either improve survival or improve symptoms and functional status among patients who are not well controlled with optimal medical therapy (OMT). A general consensus exists on the core elements of OMT, which include both lifestyle intervention and intensive secondary prevention with proven pharmacotherapies. By contrast, however, there is less general agreement as to what constitutes the optimal approach to revascularization in SIHD patients. The COURAGE and FAME 2 randomized trials form the foundation of the current clinical evidence base and raise the important question: "What is the impact of myocardial ischemia on myocardial revascularization in stable ischemic heart disease?"Original Abstract: Bei Patienten mit stabiler ischaemischer Herzkrankheit (SIHD) sollte eine myokardiale Revaskularisierung erfolgen, um entweder das Ueberleben oder die Symptome und den Funktionszustand bei Patienten zu verbessern, bei denen die Erkrankung trotz optimaler medikamentoser Therapie (OMT) nicht gut unter Kontrolle ist. Es besteht ein allgemeiner Konsens bei den Kernelementen der OMT, zu denen sowohl eine Aenderung der Lebensweise als auch eine intensive Sekundaerpraevention mit bewaehrter Pharmakotherapie gehoren. Dagegen besteht jedoch eine geringere Uebereinstimmung hinsichtlich des optimalen Ansatzes fuer die Revaskularisierung bei SIHD-Patienten. Die randomisierten Studien COURAGE und FAME 2 bilden die Grundlage der aktuellen klinischen Evidenzbasierung und werfen die wichtige Frage auf: [ldquor]Wie beeinflusst die Myokardischaemie eine myokardiale Revaskularisierung bei stabiler ischaemischer Herzkrankheit?" JF - Herz AU - Torosoff, M T AU - Sidhu AU - Boden, W E AD - Albany Medical Center, Albany, NY, USA, william.boden@va.gov Y1 - 2013/06// PY - 2013 DA - June 2013 SP - 382 EP - 386 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 38 IS - 4 SN - 0340-9937, 0340-9937 KW - Biotechnology and Bioengineering Abstracts KW - Myocardial ischemia KW - Survival KW - Ischemia KW - Clinical trials KW - Heart diseases KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850781435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Herz&rft.atitle=Impact+of+myocardial+ischemia+on+myocardial+revascularization+in+stable+ischemic+heart+disease.+Lessons+from+the+COURAGE+and+FAME+2+trials&rft.au=Torosoff%2C+M+T%3BSidhu%3BBoden%2C+W+E&rft.aulast=Torosoff&rft.aufirst=M&rft.date=2013-06-01&rft.volume=38&rft.issue=4&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=Herz&rft.issn=03409937&rft_id=info:doi/10.1007%2Fs00059-013-3824-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 20 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Myocardial ischemia; Survival; Ischemia; Clinical trials; Heart diseases DO - http://dx.doi.org/10.1007/s00059-013-3824-0 ER - TY - JOUR T1 - Outcomes of participation in the REACH multifamily group program for veterans with PTSD and their families AN - 1417549110; 201315455 AB - Posttraumatic stress disorder (PTSD) is prevalent among users of the Veterans Affairs (VA) health care system. Effective approaches to involving family in care for PTSD are critical because family functioning both affects and is affected by treatment outcomes. Although multifamily group treatment is an evidence-based practice for schizophrenia and other serious mental illnesses, no data have been published on its effectiveness for those living with PTSD and their family members. This study examined the impact of participation in REACH (Reaching out to Educate and Assist Caring, Healthy Families), an adaptation of the multifamily group psychoeducation program tailored for delivery to veterans with PTSD and their family members. One hundred veterans with PTSD and 96 family members who participated in the 9-month, 3-phase clinical program between 2006 and 2010 also participated in this longitudinal evaluation. Veterans showed significant (p < .05) improvements over time on all measures (empowerment, family problem solving and communication, relationship satisfaction, social support, symptom status, knowledge of PTSD, self-efficacy in coping with PTSD, and quality of life). Family members showed similar statistically significant improvements on most measures. Changes over time in individual participants' relationship satisfaction, social support, symptom status, and quality of life were attributable to changes in program-targeted knowledge and skills. Study results suggest that multifamily group psychoeducation is useful in treatment of PTSD, leading to increases in targeted PTSD knowledge and skills, as well as improving family functioning and symptom status for both veterans and family members. Implications for clinicians and recommendations for further evaluation of this promising intervention are described. [Copyright Elsevier B.V.] JF - Professional Psychology: Research and Practice AU - Fischer, Ellen P AU - Sherman, Michelle D AU - Han, Xiaotong AU - Owen, Richard R, Jr Y1 - 2013/06// PY - 2013 DA - June 2013 SP - 127 EP - 134 PB - American Psychological Association, Washington DC VL - 44 IS - 3 SN - 0735-7028, 0735-7028 KW - PTSD KW - family psychoeducation KW - multiple family groups KW - outcomes KW - veterans KW - REACH KW - posttraumatic stress disorder KW - Veterans KW - Symptoms KW - Posttraumatic stress disorder KW - Social support KW - Family functioning KW - Relatives KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1417549110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Psychology%3A+Research+and+Practice&rft.atitle=Outcomes+of+participation+in+the+REACH+multifamily+group+program+for+veterans+with+PTSD+and+their+families&rft.au=Fischer%2C+Ellen+P%3BSherman%2C+Michelle+D%3BHan%2C+Xiaotong%3BOwen%2C+Richard+R%2C+Jr&rft.aulast=Fischer&rft.aufirst=Ellen&rft.date=2013-06-01&rft.volume=44&rft.issue=3&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Professional+Psychology%3A+Research+and+Practice&rft.issn=07357028&rft_id=info:doi/10.1037%2Fa0032024 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-08-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Veterans; Relatives; Symptoms; Social support; Family functioning DO - http://dx.doi.org/10.1037/a0032024 ER - TY - JOUR T1 - Central Role of beta -Catenin in Anticancer Effects of Cardiac Hormones AN - 1412552314; 18229067 AB - Background: beta -Catenin causes malignant growth of colonic, pancreatic and renal cancer. Four cardiac hormones, namely atrial natriuretic peptide (ANP), vessel dilator, long-acting natriuretic peptide (LANP) and kaliuretic peptide eliminate up to 80% of human pancreatic carcinomas growing in mice. Materials and Methods: Four cardiac hormones were evaluated for their ability to reduce the expression of human beta -catenin, measured by enzyme-linked immunosorbent assay (ELISA) in human colorectal, pancreatic and renal cancer cells. Results: Vessel dilator, LANP, kaliuretic peptide, and ANP, over a concentration range of 100 pM to 10 mu M, maximally reduced expression of beta -catenin in human colorectal cancer cells by 78%, 71%, 69%, and 83%, respectively. Vessel dilator, LANP, kaliuretic peptide, and ANP reduced beta -catenin expression in human pancreatic cancer cells by 76%, 66%, 72%, and 88%, and by 64%, 54%, 58% and 73%, in human renal cancer cells, respectively. Conclusion: Part of the anticancer action of these four cardiac hormones is a potent inhibition of beta -catenin. JF - Anticancer Research AU - Skelton, WP IV AU - Skelton, M AU - Vesely, D L AD - Molecular Pharmacology and Physiology, Director, USF Cardiac Hormone Center, James A. Haley Veterans Administration Medical Center-151, 13000 Bruce B. Downs Blvd., Tampa, FL 33612, USA, david.vesely@va.gov Y1 - 2013/06// PY - 2013 DA - Jun 2013 SP - 2409 EP - 2414 VL - 33 IS - 6 SN - 0250-7005, 0250-7005 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Enzyme-linked immunosorbent assay KW - Pancreatic carcinoma KW - catenin KW - Atrial natriuretic peptide KW - Pancreatic cancer KW - Kidney KW - Colorectal cancer KW - Hormones KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1412552314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+Research&rft.atitle=Central+Role+of+beta+-Catenin+in+Anticancer+Effects+of+Cardiac+Hormones&rft.au=Skelton%2C+WP+IV%3BSkelton%2C+M%3BVesely%2C+D+L&rft.aulast=Skelton&rft.aufirst=WP&rft.date=2013-06-01&rft.volume=33&rft.issue=6&rft.spage=2409&rft.isbn=&rft.btitle=&rft.title=Anticancer+Research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-07-01 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Heart; Pancreatic carcinoma; Enzyme-linked immunosorbent assay; catenin; Atrial natriuretic peptide; Colorectal cancer; Kidney; Pancreatic cancer; Hormones ER - TY - JOUR T1 - Post-discharge mortality in patients hospitalized with MRSA infection and/or colonization AN - 1372057138; 18144548 AB - Methicillin-resistant Staphylococcus aureus (MRSA) infection is known to increase in-hospital mortality, but little is known about its association with long-term health. Two hundred and thirty-seven deaths occurred among 707 patients with MRSA infection at the time of hospitalization and/or nasal colonization followed for almost 4 years after discharge from the Atlanta Veterans Affairs Medical Center, USA. The crude mortality rate in patients with an infection and colonization (23.57/100 person-years) was significantly higher than the rate in patients with only colonization (15.67/100 person-years, P = 0.037). MRSA infection, hospitalization within past 6 months, and histories of cancer or haemodialysis were independent risk factors. Adjusted mortality rates in patients with infection were almost twice as high compared to patients who were only colonized: patients infected and colonized [hazard ratio (HR) 1.93, 95% confidence interval (CI) 1.31-2.84]; patients infected but not colonized (HR 1.96, 95% CI 1.22-3.17). Surviving MRSA infection adversely affects long-term mortality, underscoring the importance of infection control in healthcare settings. JF - Epidemiology and Infection AU - Sharma, A AU - Rogers, C AU - Rimland, D AU - Stafford, C AU - Satola, S AU - Crispell, E AU - Gaynes, R AD - Atlanta Veterans Affairs Medical Center, Decatur, GA, USA, robert.gaynes@va.gov Y1 - 2013/06// PY - 2013 DA - Jun 2013 SP - 1187 EP - 1198 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 141 IS - 6 SN - 0950-2688, 0950-2688 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Mortality KW - Historical account KW - Infection KW - Cancer KW - Colonization KW - USA KW - Health care KW - Risk factors KW - USA, Georgia, Atlanta KW - Staphylococcus aureus KW - Antibiotic resistance KW - Hospitals KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1372057138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Post-discharge+mortality+in+patients+hospitalized+with+MRSA+infection+and%2For+colonization&rft.au=Sharma%2C+A%3BRogers%2C+C%3BRimland%2C+D%3BStafford%2C+C%3BSatola%2C+S%3BCrispell%2C+E%3BGaynes%2C+R&rft.aulast=Sharma&rft.aufirst=A&rft.date=2013-06-01&rft.volume=141&rft.issue=6&rft.spage=1187&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268812001963 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-06-01 N1 - Number of references - 36 N1 - Last updated - 2013-07-26 N1 - SubjectsTermNotLitGenreText - Historical account; Colonization; Mortality; Health care; Risk factors; Infection; Antibiotic resistance; Cancer; Hospitals; Staphylococcus aureus; USA; USA, Georgia, Atlanta DO - http://dx.doi.org/10.1017/S0950268812001963 ER - TY - JOUR T1 - A simple, closed-form, mathematical model for gas exchange in microchannel artificial lungs AN - 1356931862; 18039772 AB - Microfabrication techniques are attractive for constructing artificial lungs due to the ability to create features similar in size to those in the natural lung. However, a simple and intuitive mathematical model capable of accurately predicting the gas exchange performance of microchannel artificial lungs does not currently exist. Such a model is critical to understanding and optimizing these devices. Here, we describe a simple, closed-form mathematical model for gas exchange in microchannel artificial lungs and qualify it through application to experimental data from several research groups. We utilize lumped parameters and several assumptions to obtain a closed-form set of equations that describe gas exchange. This work is intended to augment computational models by providing a more intuitive, albeit potentially less accurate, understanding of the operation and trade-offs inherent in microchannel artificial lung devices. JF - Biomedical Microdevices AU - Potkay, Joseph A AD - Advanced Platform Technology Center, VA Ann Arbor Healthcare System, Ann Arbor, MI, 48105, USA, Joseph.Potkay@va.gov Y1 - 2013/06// PY - 2013 DA - Jun 2013 SP - 397 EP - 406 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 15 IS - 3 SN - 1387-2176, 1387-2176 KW - Biotechnology and Bioengineering Abstracts KW - Gas exchange KW - Mathematical models KW - Data processing KW - Lung KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356931862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+Microdevices&rft.atitle=A+simple%2C+closed-form%2C+mathematical+model+for+gas+exchange+in+microchannel+artificial+lungs&rft.au=Potkay%2C+Joseph+A&rft.aulast=Potkay&rft.aufirst=Joseph&rft.date=2013-06-01&rft.volume=15&rft.issue=3&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Biomedical+Microdevices&rft.issn=13872176&rft_id=info:doi/10.1007%2Fs10544-013-9736-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Number of references - 28 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Gas exchange; Data processing; Mathematical models; Lung DO - http://dx.doi.org/10.1007/s10544-013-9736-1 ER - TY - JOUR T1 - Health Information During the H1N1 Influenza Pandemic: Did the Amount Received Influence Infection Prevention Behaviors? AN - 1356928095; 17972994 AB - In the wake of uncertainty due to the H1N1 influenza pandemic, amount and sources of H1N1-related information were examined in a cohort at high-risk for respiratory complications. Factors associated with adequate amount of information were identified. A cross-sectional mailed survey was conducted in 2010 with veterans with spinal cord injuries and disorders. Bivariate comparisons assessed adequate H1N1-realted information versus not enough and too much. Multivariate regression identified variables associated with receipt of adequate information. A greater proportion who received adequate versus not enough information received H1N1 vaccination (61.87 vs. 48.49 %, p < 0.0001). A greater proportion who received adequate versus too much information received seasonal vaccination (84.90 vs. 71.02 %, p < 0.0001) and H1N1 vaccination (61.87 vs. 42.45 %, p < 0.0001). Variables associated with greater odds of receiving adequate information included being white, a college graduate, and having VA health professionals as their primary information source. Receiving adequate information was associated with lower odds of staying home with flu/flu-like symptoms, and higher odds of H1N1 vaccine receipt and wearing a facemask. Receiving appropriate amounts of information from valid sources may impact adherence to infection control recommendations during pandemics. Findings can be used to facilitate efforts ensuring information is received by high-risk populations. JF - Journal of Community Health AU - Etingen, Bella AU - LaVela, Sherri L AU - Miskevics, Scott AU - Goldstein, Barry AD - Center for Management of Complex Chronic Care, Hines VA Hospital, 5000 S. 5th Avenue (151H), Hines, IL, 60141, USA, Bella.Etingen@va.gov Y1 - 2013/06// PY - 2013 DA - Jun 2013 SP - 443 EP - 450 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 38 IS - 3 SN - 0094-5145, 0094-5145 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Injuries KW - Complications KW - Spinal cord injury KW - Infection KW - Vaccination KW - Influenza KW - Prevention KW - pandemics KW - Behavior KW - Risk groups KW - Vaccines KW - V 22320:Replication KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356928095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Health+Information+During+the+H1N1+Influenza+Pandemic%3A+Did+the+Amount+Received+Influence+Infection+Prevention+Behaviors%3F&rft.au=Etingen%2C+Bella%3BLaVela%2C+Sherri+L%3BMiskevics%2C+Scott%3BGoldstein%2C+Barry&rft.aulast=Etingen&rft.aufirst=Bella&rft.date=2013-06-01&rft.volume=38&rft.issue=3&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-012-9647-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Number of references - 20 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Influenza; pandemics; Risk groups; Spinal cord injury; Vaccines; Infection; Vaccination; Prevention; Injuries; Behavior; Complications DO - http://dx.doi.org/10.1007/s10900-012-9647-8 ER - TY - JOUR T1 - Predicting 30-day all-cause hospital readmissions AN - 1352283653; 17940481 AB - Hospital readmission rate has been broadly accepted as a quality measure and cost driver. However, success in reducing readmissions has been elusive. In the US, almost 20 % of Medicare inpatients are rehospitalized within 30 days, which amounts to a cost of $17 billion. Given the skyrocketing healthcare cost, policymakers, researchers and payers are focusing more than ever on readmission reduction. Both hospital comparison of readmissions as a quality measure and identification of high-risk patients for post-discharge interventions require accurate predictive modeling. However, most predictive models for readmissions perform poorly. In this study, we endeavored to explore the full potentials of predictive models for readmissions and to assess the predictive power of different independent variables. Our model reached the highest predicting ability (c-statistic =0.80) among all published studies that used administrative data. Our analyses reveal that demographics, socioeconomic variables, prior utilization and Diagnosis-related Group (DRG) all have limited predictive power; more sophisticated patient stratification algorithm or risk adjuster is desired for more accurate readmission predictions. JF - Health Care Management Science AU - Shulan, Mollie AU - Gao, Kelly AU - Moore, Crystal Dea AD - Department of Veterans Affairs, Stratton VA Medical Center, 113 Holland Avenue, Albany, NY, 12208, USA, mollie.shulan@va.gov Y1 - 2013/06// PY - 2013 DA - Jun 2013 SP - 167 EP - 175 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 16 IS - 2 SN - 1386-9620, 1386-9620 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Prediction KW - Demography KW - Health care KW - Prediction models KW - Socioeconomics KW - Intervention KW - Stratification KW - Hospitals KW - H 13000:Medical Safety KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1352283653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Care+Management+Science&rft.atitle=Predicting+30-day+all-cause+hospital+readmissions&rft.au=Shulan%2C+Mollie%3BGao%2C+Kelly%3BMoore%2C+Crystal+Dea&rft.aulast=Shulan&rft.aufirst=Mollie&rft.date=2013-06-01&rft.volume=16&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Health+Care+Management+Science&rft.issn=13869620&rft_id=info:doi/10.1007%2Fs10729-013-9220-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Number of references - 34 N1 - Last updated - 2013-07-26 N1 - SubjectsTermNotLitGenreText - Demography; Prediction; Health care; Prediction models; Intervention; Socioeconomics; Stratification; Hospitals DO - http://dx.doi.org/10.1007/s10729-013-9220-8 ER - TY - JOUR T1 - Towards public health decision support: a systematic review of bidirectional communication approaches AN - 1551624995; 20322330 AB - ObjectiveTo summarize the literature describing computer-based interventions aimed at improving bidirectional communication between clinical and public health.Materials and MethodsA systematic review of English articles using MEDLINE and Google Scholar. Search terms included public health, epidemiology, electronic health records, decision support, expert systems, and decision-making. Only articles that described the communication of information regarding emerging health threats from public health agencies to clinicians or provider organizations were included. Each article was independently reviewed by two authors.ResultsTen peer-reviewed articles highlight a nascent but promising area of research and practice related to alerting clinicians about emerging threats. Current literature suggests that additional research and development in bidirectional communication infrastructure should focus on defining a coherent architecture, improving interoperability, establishing clear governance, and creating usable systems that will effectively deliver targeted, specific information to clinicians in support of patient and population decision-making.ConclusionsIncreasingly available clinical information systems make it possible to deliver timely, relevant knowledge to frontline clinicians in support of population health. Future work should focus on developing a flexible, interoperable infrastructure for bidirectional communications capable of integrating public health knowledge into clinical systems and workflows. JF - Journal of the American Medical Informatics Association AU - Dixon, Brian E AU - Gamache, Roland E AU - Grannis, Shaun J AD - Center of Excellence on Implementing Evidence-Based Practice, Veterans Health Administration, Health Services Research and Development Service, Department of Veterans Affairs, Indianapolis, Indiana, USA Y1 - 2013/05/06/ PY - 2013 DA - 2013 May 06 SP - 577 EP - 583 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Bethesda MD 20814 United States VL - 20 IS - 3 SN - 1067-5027, 1067-5027 KW - Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts KW - Informatics KW - Decision support systems KW - Intervention KW - Public health KW - Infrastructure KW - Decision making KW - Communications KW - Epidemiology KW - Reviews KW - Expert systems KW - Research programs KW - Information systems KW - H 12000:Epidemiology and Public Health KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1551624995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Towards+public+health+decision+support%3A+a+systematic+review+of+bidirectional+communication+approaches&rft.au=Dixon%2C+Brian+E%3BGamache%2C+Roland+E%3BGrannis%2C+Shaun+J&rft.aulast=Dixon&rft.aufirst=Brian&rft.date=2013-05-06&rft.volume=20&rft.issue=3&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/10.1136%2Famiajnl-2012-001514 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-08-01 N1 - Last updated - 2014-08-21 N1 - SubjectsTermNotLitGenreText - Decision making; Epidemiology; Informatics; Reviews; Expert systems; Information systems; Public health; Infrastructure; Communications; Decision support systems; Intervention; Research programs DO - http://dx.doi.org/10.1136/amiajnl-2012-001514 ER - TY - JOUR T1 - Magnitude and Time Course of Changes Induced by Continuous-Flow Left Ventricular Assist Device Unloading in Chronic Heart Failure: Insights Into Cardiac Recovery AN - 1837335334; PQ0001036206 AB - Objectives This study sought to prospectively investigate the longitudinal effects of continuous-flow left ventricular assist device (LVAD) unloading on myocardial structure and systolic and diastolic function. Background The magnitude, timeline, and sustainability of changes induced by continuous-flow LVAD on the structure and function of the failing human heart are unknown. Methods Eighty consecutive patients with clinical characteristics consistent with chronic heart failure requiring implantation of a continuous-flow LVAD were prospectively enrolled. Serial echocardiograms (at 1, 2, 3, 4, 6, 9, and 12 months) and right heart catheterizations were performed after LVAD implant. Cardiac recovery was assessed on the basis of improvement in systolic and diastolic function indices on echocardiography that were sustained during LVAD turn-down studies. Results After 6 months of LVAD unloading, 34% of patients had a relative LV ejection fraction increase above 50% and 19% of patients, both ischemic and nonischemic, achieved an LV ejection fraction greater than or equal to 40%. LV systolic function improved as early as 30 days, the greatest degree of improvement was achieved by 6 months of mechanical unloading and persisted over the 1-year follow up. LV diastolic function parameters also improved as early as 30 days after LVAD unloading, and this improvement persisted over time. LV end-diastolic and end-systolic volumes decreased as early as 30 days after LVAD unloading (113 vs. 77 ml/m2, p < 0.01, and 92 vs. 60 ml/m2, p < 0.01, respectively). LV mass decreased as early as 30 days after LVAD unloading (114 vs. 95 g/m2, p < 0.05) and continued to do so over the 1-year follow-up but did not reach values below the normal reference range, suggesting no atrophic remodeling after prolonged LVAD unloading. Conclusions Continuous-flow LVAD unloading induced in a subset of patients, both ischemic and nonischemic, early improvement in myocardial structure and systolic and diastolic function that was largely completed within 6 months, with no evidence of subsequent regression. JF - Journal of the American College of Cardiology AU - Drakos, Stavros G AU - Wever-Pinzon, Omar AU - Selzman, Craig H AU - Gilbert, Edward M AU - Alharethi, Rami AU - Reid, Bruce B AU - Saidi, Abdulfattah AU - Diakos, Nikolaos A AU - Stoker, Sandi AU - Davis, Erin S AU - Movsesian, Matthew AU - Li, Dean Y AU - Stehlik, Josef AU - Kfoury, Abdallah G AD - Utah Transplantation Affiliated Hospitals (UTAH) Cardiac Transplant Program, Divisions of Cardiology and Cardiothoracic Surgery, University of Utah Health Sciences Center, Intermountain Medical Center, Veterans Administration Salt Lake City Health Care System, Salt Lake City, Utah Y1 - 2013/05// PY - 2013 DA - May 2013 SP - 1985 EP - 1994 PB - Elsevier Science Ltd., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 61 IS - 19 SN - 0735-1097, 0735-1097 KW - Toxicology Abstracts KW - cardiac recovery KW - left ventricular assist device KW - mechanical unloading KW - myocardial function KW - myocardial structure KW - CI confidence interval KW - HF heart failure KW - LA left atrium KW - LV left ventricle KW - LVAD left ventricular assist device(s) KW - LVEF left ventricular ejection fraction KW - RV right ventricle KW - Heart KW - Ventricle KW - Catheterization KW - Mechanical unloading KW - Structure-function relationships KW - Echocardiography KW - Ischemia KW - Heart diseases KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837335334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Magnitude+and+Time+Course+of+Changes+Induced+by+Continuous-Flow+Left+Ventricular+Assist+Device+Unloading+in+Chronic+Heart+Failure%3A+Insights+Into+Cardiac+Recovery&rft.au=Drakos%2C+Stavros+G%3BWever-Pinzon%2C+Omar%3BSelzman%2C+Craig+H%3BGilbert%2C+Edward+M%3BAlharethi%2C+Rami%3BReid%2C+Bruce+B%3BSaidi%2C+Abdulfattah%3BDiakos%2C+Nikolaos+A%3BStoker%2C+Sandi%3BDavis%2C+Erin+S%3BMovsesian%2C+Matthew%3BLi%2C+Dean+Y%3BStehlik%2C+Josef%3BKfoury%2C+Abdallah+G&rft.aulast=Drakos&rft.aufirst=Stavros&rft.date=2013-05-01&rft.volume=61&rft.issue=19&rft.spage=1985&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/10.1016%2Fj.jacc.2013.01.072 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 34 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Heart; Catheterization; Ventricle; Mechanical unloading; Structure-function relationships; Echocardiography; Ischemia; Heart diseases DO - http://dx.doi.org/10.1016/j.jacc.2013.01.072 ER - TY - JOUR T1 - Travel Characteristics and Yellow Fever Vaccine Usage Among US Global TravEpiNet Travelers Visiting Countries with Risk of Yellow Fever Virus Transmission, 2009-2011 AN - 1647007051; 21172091 AB - Yellow fever (YF) vaccine-associated serious adverse events and changing YF epidemiology have challenged healthcare providers to vaccinate only travelers whose risk of YF during travel is greater than their risk of adverse events. We describe the travel characteristics and YF vaccine use among US travelers visiting Global TravEpiNet clinics from January of 2009 to March of 2011. Of 16,660 travelers, 5,588 (34%) had itineraries to areas with risk of YF virus transmission. Of those travelers visiting one country with YF risk (N = 4,517), 71% were vaccinated at the visit, and 20% were presumed to be immune from prior vaccination. However, travelers visiting friends and relatives (odds ratio [OR] = 2.57, 95% confidence interval [95% CI] = 1.27-5.22) or going to Nigeria (OR = 3.01, 95% CI = 1.37-6.62) were significantly more likely to decline vaccination. To optimize YF vaccine use, clinicians should discuss an individual's risk-benefit assessment of vaccination and close knowledge gaps regarding vaccine use among at-risk populations. JF - American Journal of Tropical Medicine and Hygiene AU - Jentes, Emily S AU - Han, Pauline AU - Gershman, Mark D AU - Rao, Sowmya R AU - LaRocque, Regina C AU - Erin Staples, J AU - Ryan, Edward T AD - Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts; Center for Health Quality, Outcomes, and Economic Research, Bedford Veterans Administration Medical Center, Bedford, Massachusetts; Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Ft. Collins, Colorado; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, 1600 Clifton Road, MS E-03, Atlanta, GA 30333, ejentes@cdc.gov Y1 - 2013/05// PY - 2013 DA - May 2013 SP - 954 EP - 961 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 88 IS - 5 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Risk Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Risk assessment KW - Travel KW - Nigeria KW - Disease control KW - Vaccination KW - Medical personnel KW - Risks KW - Yellow fever virus KW - Epidemiology KW - Yellow fever KW - Vaccines KW - Hygiene KW - Side effects KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - J 02350:Immunology KW - R2 23060:Medical and environmental health KW - Q5 08524:Public health, medicines, dangerous organisms KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647007051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Travel+Characteristics+and+Yellow+Fever+Vaccine+Usage+Among+US+Global+TravEpiNet+Travelers+Visiting+Countries+with+Risk+of+Yellow+Fever+Virus+Transmission%2C+2009-2011&rft.au=Jentes%2C+Emily+S%3BHan%2C+Pauline%3BGershman%2C+Mark+D%3BRao%2C+Sowmya+R%3BLaRocque%2C+Regina+C%3BErin+Staples%2C+J%3BRyan%2C+Edward+T&rft.aulast=Jentes&rft.aufirst=Emily&rft.date=2013-05-01&rft.volume=88&rft.issue=5&rft.spage=954&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.12-0463 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Epidemiology; Disease control; Vaccines; Hygiene; Vaccination; Risks; Travel; Yellow fever; Risk assessment; Medical personnel; Side effects; Yellow fever virus; Nigeria DO - http://dx.doi.org/10.4269/ajtmh.12-0463 ER - TY - JOUR T1 - Evidence-based competencies for improving communication skills in graduate medical education: A review with suggestions for implementation AN - 1558988517; 201429524 AB - Communicating with patients is arguably the most common and important activity in medical practice, but this activity receives relatively little emphasis in graduate medical education. We propose 12 evidence-based communication competencies that program directors can adopt as a framework for teaching and evaluating residents' communication skills. We review supporting evidence for these competencies and argue that communication should be treated like a procedural skill that must be taught and evaluated by observing real resident-patient interactions. We make practical suggestions for implementing these competencies by addressing three critical components of a competency-based approach to communication skills: patient safety, faculty development, and direct observation of residents. This approach to teaching and assessing communication skills provides a rationale for incorporating routine direct observation into graduate medical education programs and also for designing communication skills training that ensures graduating residents develop the skills needed to provide safe, effective patient care. Adapted from the source document. JF - Medical Teacher AU - Henry, Stephen G AU - Holmboe, Eric S AU - Frankel, Richard M AD - Division of General Medicine, Geriatrics, and Bioethics, University of California Davis School of Medicine, 4150 V Street, Suite 2400, Sacramento, CA 95817, USA; American Board of Internal Medicine and the ABIM Foundation, USA; Indiana University School of Medicine, USA; Mary Margaret Walther Center for Research and Education in Palliative Care, USA; Richard L. Roudebush Veterans Administration Medical Center, USA sghenry@ucdavis.edu Y1 - 2013/05// PY - 2013 DA - May 2013 SP - 395 EP - 403 PB - Informa Healthcare VL - 35 IS - 5 SN - 0142-159X, 0142-159X KW - Evidence based KW - Professional development KW - Teaching KW - Communication skills KW - Medical education KW - Patient care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558988517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Teacher&rft.atitle=Evidence-based+competencies+for+improving+communication+skills+in+graduate+medical+education%3A+A+review+with+suggestions+for+implementation&rft.au=Henry%2C+Stephen+G%3BHolmboe%2C+Eric+S%3BFrankel%2C+Richard+M&rft.aulast=Henry&rft.aufirst=Stephen&rft.date=2013-05-01&rft.volume=35&rft.issue=5&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Medical+Teacher&rft.issn=0142159X&rft_id=info:doi/10.3109%2F0142159X.2013.769677 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - MEDTDX N1 - SubjectsTermNotLitGenreText - Communication skills; Medical education; Patient care; Evidence based; Teaching; Professional development DO - http://dx.doi.org/10.3109/0142159X.2013.769677 ER - TY - JOUR T1 - A Randomized Controlled Trial of a Web-Delivered Brief Alcohol Intervention in Veterans Affairs Primary Care AN - 1463069637; 201325697 AB - Objective: This study sought to examine whether a web-delivered brief alcohol intervention (BAI) is effective for reducing alcohol misuse in U.S. military veterans presenting to primary care. Method: Veterans (N = 167) screening positive for alcohol misuse during a routine primary care visit were randomized to receive a BAI plus treatment as usual (TAU) or TAU alone. An assessment of alcohol-related outcomes was conducted at baseline and 3 and 6 months after treatment. Results: Veterans in both study conditions showed a significant reduction in alcohol quantity and frequency and alcohol-related problems at 6-month follow-up. No differential treatment effects on outcomes were observed between the two treatment groups. Conclusions: This study is the first to explore whether a web-delivered BAI using normative feedback is effective for veterans with alcohol misuse. Our findings suggest that BAIs using normative feedback may not have any additional benefit beyond TAU for older veterans with high rates of comorbid mental health concerns. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Cucciare, Michael A AU - Weingardt, Kenneth R AU - Ghaus, Sharfun AU - Boden, Matthew T AU - Frayne, Susan M AD - Research Health Science Specialist, Center for Health Care Evaluation, VA Palo Alto Health Care System, 795 Willow Road (152), Menlo Park, CA 94025, or via michael.cucciare@va.gov Y1 - 2013/05// PY - 2013 DA - May 2013 SP - 428 EP - 436 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 74 IS - 3 SN - 1937-1888, 1937-1888 KW - Drug education KW - Veterans KW - Alcohol abuse KW - Primary health care KW - Feedback KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1463069637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=A+Randomized+Controlled+Trial+of+a+Web-Delivered+Brief+Alcohol+Intervention+in+Veterans+Affairs+Primary+Care&rft.au=Cucciare%2C+Michael+A%3BWeingardt%2C+Kenneth+R%3BGhaus%2C+Sharfun%3BBoden%2C+Matthew+T%3BFrayne%2C+Susan+M&rft.aulast=Cucciare&rft.aufirst=Michael&rft.date=2013-05-01&rft.volume=74&rft.issue=3&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-12-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Veterans; Primary health care; Alcohol abuse; Drug education; Feedback; Comorbidity ER - TY - JOUR T1 - Standardized Beck Depression Inventory-II scores for male veterans coping with chronic pain AN - 1438670917; 201321475 AB - The Beck Depression Inventory II (BDI-II) has been suspected of overestimating the level of depression in individuals that endure chronic pain. Using a sample (N = 345) of male military veterans with chronic pain enrolled in an outpatient treatment program, a factor analysis on the BDI-II revealed a "Somatic Complaints" factor along with 2 other factors we labeled "Negative Rumination" and "Mood." Standardized scores were provided for each BDI-II factor score, Total score, and Total minus Somatic score. The internal consistency reliabilities (Gilmer-Feldt and alpha coefficients) for all scores were found to be clinically acceptable. Item-Total score correlations found that all of the BDI-II items were good discriminators (r > .30). We conclude that the normative data provided in this study should help control for somatic responding by male chronic pain veterans on the BDI-II. We highly recommend that clinicians and researchers use the norm-referenced method when interpreting BDI-II scores from individuals suffering from chronic pain. [Copyright Elsevier B.V.] JF - Psychological Services AU - Lopez, Michael N AU - Pierce, Russell S AU - Gardner, Ricca D AU - Hanson, Richard W AD - michael.lopez@va.gov Y1 - 2013/05// PY - 2013 DA - May 2013 SP - 257 EP - 263 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 10 IS - 2 SN - 1541-1559, 1541-1559 KW - chronic pain KW - depression KW - factor analysis KW - somatic KW - standardized Beck Depression Inventory-II scores KW - male veterans KW - coping KW - Suffering KW - Veterans KW - Rumination KW - Depression KW - Chronic pain KW - Men KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438670917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Standardized+Beck+Depression+Inventory-II+scores+for+male+veterans+coping+with+chronic+pain&rft.au=Lopez%2C+Michael+N%3BPierce%2C+Russell+S%3BGardner%2C+Ricca+D%3BHanson%2C+Richard+W&rft.aulast=Lopez&rft.aufirst=Michael&rft.date=2013-05-01&rft.volume=10&rft.issue=2&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0027920 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Chronic pain; Veterans; Men; Depression; Suffering; Rumination DO - http://dx.doi.org/10.1037/a0027920 ER - TY - JOUR T1 - Housing assistance and case management: Improving access to substance use disorder treatment for homeless veterans AN - 1438667572; 201322521 AB - The problem of waiting list attrition in addiction treatment programs is widespread, and homeless and marginally housed individuals are particularly susceptible. This naturalistic, retrospective study describes an intervention (Transitional Supportive Housing and Case Management) that effectively promoted treatment admission for this high-risk group above and beyond that which could be explained by certain pretreatment factors. The clinical records of 211 military veterans referred to intensive outpatient addiction treatment were reviewed for factors related to treatment program admission, including 3 interventions designed to prevent waiting list attrition. Chi-square tests evaluated univariate predictors of treatment entry, and a hierarchical binary logistic regression evaluated several variables simultaneously. Results showed that fewer than 50% of wait-listed patients achieved treatment admission. Univariate predictors of treatment entry were not having a current partner, having a legal problem, and having had past substance use disorder treatment. The logistic regression showed that patients who received the intervention were 4.5 times more likely to enter the treatment program, and individuals with a current legal problem were 2.5 times more likely to enter treatment. Participation in a weekly support group and/or contact with a psychiatric nurse practitioner did not increase the likelihood of program admission. It may be possible to enhance treatment entry for the homeless and marginally housed by providing case management and housing services. Future research is needed to determine how the individual-level factors predicting treatment entry in this study can be used to tailor other interventions to further address the problem of waiting list attrition. [Copyright Elsevier B.V.] JF - Psychological Services AU - Winn, Jaime L AU - Shealy, Suzanne E AU - Kropp, Gary J AU - Felkins-Dohm, Donna AU - Gonzales-Nolas, Cheryl AU - Francis, Elie Y1 - 2013/05// PY - 2013 DA - May 2013 SP - 233 EP - 240 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 10 IS - 2 SN - 1541-1559, 1541-1559 KW - access to treatment KW - addiction KW - case management KW - homelessness KW - housing assistance KW - substance use disorder KW - veterans KW - treatment KW - outpatients KW - Admissions KW - Case management KW - Attrition KW - Homeless people KW - Treatment methods KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438667572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Housing+assistance+and+case+management%3A+Improving+access+to+substance+use+disorder+treatment+for+homeless+veterans&rft.au=Winn%2C+Jaime+L%3BShealy%2C+Suzanne+E%3BKropp%2C+Gary+J%3BFelkins-Dohm%2C+Donna%3BGonzales-Nolas%2C+Cheryl%3BFrancis%2C+Elie&rft.aulast=Winn&rft.aufirst=Jaime&rft.date=2013-05-01&rft.volume=10&rft.issue=2&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0031051 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Admissions; Homeless people; Substance abuse; Case management; Attrition; Treatment methods DO - http://dx.doi.org/10.1037/a0031051 ER - TY - JOUR T1 - Veterans administration health care utilization among sexual minority veterans AN - 1438667343; 201322166 AB - According to recent census reports, nearly a million veterans have a same-sex partner, yet little is known about them or their use of Veterans Health Care Administration (VHA) services. Gay, lesbian, and bisexual (GLB) veterans recruited from the community (N = 356) completed an on-line survey to assess their rates of VHA utilization and whether they experience specific barriers to accessing VHA services. Andersen's model of health care utilization was adapted to provide an analytic and conceptual framework. Overall, 45.5% reported lifetime VHA utilization and 28.7% reported past-year VHA utilization. Lifetime VHA health care utilization was predicted by positive service connection, positive screen for both posttraumatic stress disorder (PTSD) and depression, and history of at least one interpersonal trauma during military service related to respondent's GLB status. Past-year VHA health care utilization was predicted by female gender, positive service connection, positive screen for both PTSD and depression, lower physical functioning, a history of military interpersonal trauma related to GLB status, and no history of stressful experiences initiated by the military to investigate or punish GLB status. Rates of VHA utilization by GLB veterans in this sample are comparable to those reported by VHA Central Office for all veterans. Of those who utilized VHA services, 33% reported open communication about their sexual orientation with VHA providers. Twenty-five percent of all participants reported avoiding at least one VHA service because of concerns about stigma. Stigma and lack of communication between GLB veterans and their providers about sexual orientation are areas of concern for VHA. [Copyright Elsevier B.V.] JF - Psychological Services AU - Simpson, Tracy L AU - Balsam, Kimberly F AU - Cochran, Bryan N AU - Lehavot, Keren AU - Gold, Sari D Y1 - 2013/05// PY - 2013 DA - May 2013 SP - 223 EP - 232 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 10 IS - 2 SN - 1541-1559, 1541-1559 KW - bisexual KW - gay KW - health care utilization KW - lesbian KW - veterans KW - Veterans Health Care Administration services KW - Veterans KW - Stigmatization KW - Posttraumatic stress disorder KW - Sexual orientation KW - Military hospitals KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438667343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Veterans+administration+health+care+utilization+among+sexual+minority+veterans&rft.au=Simpson%2C+Tracy+L%3BBalsam%2C+Kimberly+F%3BCochran%2C+Bryan+N%3BLehavot%2C+Keren%3BGold%2C+Sari+D&rft.aulast=Simpson&rft.aufirst=Tracy&rft.date=2013-05-01&rft.volume=10&rft.issue=2&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0031281 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Veterans; Helpseeking; Posttraumatic stress disorder; Sexual orientation; Military hospitals; Stigmatization DO - http://dx.doi.org/10.1037/a0031281 ER - TY - JOUR T1 - Pain, depression, and health care utilization over time after spinal cord injury AN - 1438666852; 201322363 AB - Objective: The aim of this research was to examine comorbid pain and depression after spinal cord injury (SCI) in terms of: frequency, longitudinal course, and associations with medical conditions and use of SCI specialty care. Method: Three consecutive standardized annual psychological evaluations were reviewed for 286 persons with SCI receiving care at an SCI specialty care center. Chart abstraction included medical and demographic information, a depression scale, and a pain scale. Administrative databases were used to collect SCI specialty care utilization data. Participants were categorized as having elevated pain, elevated depression, both elevated pain and depression, or neither elevated, using cut-off scores on the pain and depression scales. ANOVA and repeated measures ANOVA were used to compare study groups. Results: Approximately 20% of the sample showed both elevated pain and depression at Year 1. Persons with elevated pain and depression showed higher scores on those measures than did persons with either pain or depression alone. Pain scores tended to be stable over time. Depression scores tended to improve over 3 years, but persons with elevated pain and depression showed less improvement on depression scores than did persons with depression alone. Persons with pain and depression tended to utilize more SCI specialty care. Conclusions: Pain and depression are often comorbid after SCI. This comorbidity is associated with higher pain and depression severity, more persistent pain and depression over time, and more use of SCI specialty care. Comorbid pain and depression should be anticipated among persons with SCI and addressed in care plans. [Copyright The American Psychological Association.] JF - Rehabilitation Psychology AU - Ullrich, Philip M AU - Lincoln, Randi K AU - Tackett, M Jan AU - Miskevics, Scott AU - Smith, Bridget M AU - Weaver, Frances M Y1 - 2013/05// PY - 2013 DA - May 2013 SP - 158 EP - 165 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 58 IS - 2 SN - 0090-5550, 0090-5550 KW - depression KW - health care KW - pain KW - spinal cord injury KW - comorbidity KW - frequency KW - longitudinal course KW - specialty care KW - Medical conditions KW - Depression KW - Spinal cord injuries KW - Pain KW - Comorbidity KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438666852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rehabilitation+Psychology&rft.atitle=Pain%2C+depression%2C+and+health+care+utilization+over+time+after+spinal+cord+injury&rft.au=Ullrich%2C+Philip+M%3BLincoln%2C+Randi+K%3BTackett%2C+M+Jan%3BMiskevics%2C+Scott%3BSmith%2C+Bridget+M%3BWeaver%2C+Frances+M&rft.aulast=Ullrich&rft.aufirst=Philip&rft.date=2013-05-01&rft.volume=58&rft.issue=2&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Rehabilitation+Psychology&rft.issn=00905550&rft_id=info:doi/10.1037%2Fa0032047 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Depression; Pain; Comorbidity; Spinal cord injuries; Helpseeking; Medical conditions DO - http://dx.doi.org/10.1037/a0032047 ER - TY - JOUR T1 - Influence of trauma history on panic and posttraumatic stress disorder in returning veterans AN - 1438664253; 201320371 AB - The current study examined the role of predeployment sexual and physical abuse, combat exposure, and postdeployment social support in predicting panic disorder and PTSD diagnoses in a large sample of returning veterans. A chart review was conducted for 1740 OEF/OIF veterans who received mental health screenings at a large VA hospital between May 24, 2004 and March 26, 2008. Assessments included psychosocial evaluations conducted by psychiatrists, psychologists, and social workers in addition to self-report measures. Results suggested that the prevalence of panic disorder (6.1%) and PTSD (28.7%) are elevated among OEF/OIF veterans. Veterans reporting higher levels of combat experience were likely to be diagnosed with PTSD (odds ration [OR], 1.17; 95% confidence interval [CI], 1.10-1.25; p < .001) or comorbid panic disorder and PTSD (OR, 1.18; 95% CI, 1.04-1.33; p < .001). Veterans endorsing predeployment sexual abuse were likely to be diagnosed with comorbid panic disorder and PTSD (OR, 3.05; 95% CI, 1.15-8.08; p < .05), as were veterans endorsing predeployment physical abuse (OR, 0.47; 95% CI, 0.22-1.00; p < .05). Panic disorder was also found to be associated with greater risk for suicide attempts than PTSD ([chi]2 = 16.38, p = .001). These findings indicate a high prevalence of panic disorder among returning veterans and highlight the importance for clinicians to assess returning veterans routinely for panic disorder in addition to PTSD. [Copyright Elsevier B.V.] JF - Psychological Services AU - Barrera, Terri L AU - Graham, David P AU - Dunn, Nancy Jo AU - Teng, Ellen J Y1 - 2013/05// PY - 2013 DA - May 2013 SP - 168 EP - 176 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 10 IS - 2 SN - 1541-1559, 1541-1559 KW - panic disorder KW - posttraumatic stress disorder KW - suicide attempts KW - trauma KW - veterans KW - predeployment KW - postdeployment KW - sexual abuse KW - physical abuse KW - social support KW - Veterans KW - Posttraumatic stress disorder KW - Sexual abuse KW - Panic disorders KW - Comorbidity KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438664253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Influence+of+trauma+history+on+panic+and+posttraumatic+stress+disorder+in+returning+veterans&rft.au=Barrera%2C+Terri+L%3BGraham%2C+David+P%3BDunn%2C+Nancy+Jo%3BTeng%2C+Ellen+J&rft.aulast=Barrera&rft.aufirst=Terri&rft.date=2013-05-01&rft.volume=10&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0031178 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Veterans; Posttraumatic stress disorder; Panic disorders; Prevalence; Comorbidity; Sexual abuse DO - http://dx.doi.org/10.1037/a0031178 ER - TY - JOUR T1 - Perceived military organizational support and peacekeeper distress: A longitudinal investigation AN - 1438663629; 201320370 AB - Many professions vital to the safety of society require workers to face high magnitude and potentially traumatizing events. Because this routine exposure can cause high levels of stress in workers, it is important to investigate factors that contribute to both risk of posttraumatic stress disorder (PTSD), and healthy responses to stress. Although some research has found social support to mitigate the effects of posttraumatic stress symptoms, scant research has investigated organizational support. The aim of the present study is to investigate the temporal relationship between stress symptoms and perceived organizational support in a sample of 1,039 service members deployed to the peacekeeping mission to Kosovo. Participants completed self-report measures of stress symptoms and perceived organizational support at 4 study time points. Bivariate latent difference score structural equation modeling was utilized to examine the temporal relationship among stress and perceived organizational support. In general, across the 4 time points, latent PCL scores evidenced a salient and negative relationship to subsequent POS latent difference scores. However, no significant relationship was found between latent POS variables and subsequent PCL latent difference scores. Findings suggest that prior stress symptoms are influencing service member's perceptions of the supportiveness of their organization such that increased prior stress is associated with worsening perceptions of support. These results illustrate that targeting stress directly may potentiate the positive influence of organizational support and that institutional support programs should be adapted to better account for the negative biases increased distress may encourage. [Copyright Elsevier B.V.] JF - Psychological Services AU - Barnes, J Ben AU - Nickerson, Angela AU - Adler, Amy B AU - Litz, Brett T Y1 - 2013/05// PY - 2013 DA - May 2013 SP - 177 EP - 185 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 10 IS - 2 SN - 1541-1559, 1541-1559 KW - peacekeeping KW - perceived organizational support KW - posttraumatic stress KW - stress KW - structural equation modeling KW - military KW - Organizational support KW - Symptoms KW - Perceptions KW - Posttraumatic stress disorder KW - Stress KW - Difference scores KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438663629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Perceived+military+organizational+support+and+peacekeeper+distress%3A+A+longitudinal+investigation&rft.au=Barnes%2C+J+Ben%3BNickerson%2C+Angela%3BAdler%2C+Amy+B%3BLitz%2C+Brett+T&rft.aulast=Barnes&rft.aufirst=J&rft.date=2013-05-01&rft.volume=10&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0032607 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Stress; Organizational support; Symptoms; Difference scores; Posttraumatic stress disorder; Perceptions DO - http://dx.doi.org/10.1037/a0032607 ER - TY - JOUR T1 - Posttraumatic Stress Disorder and Cannabis Use Characteristics among Military Veterans with Cannabis Dependence AN - 1373488453; 201312328 AB - Background and Objectives: The present study is the first to explore links between PTSD and cannabis use characteristics immediately prior to a cannabis quit attempt, including motives, use problems, withdrawal, and craving. Methods: Measures of PTSD diagnosis, symptom severity, and cannabis use characteristics were administered to a sample of cannabis dependent military veterans (n = 94). Hypotheses were tested with a series of analyses of variance and covariance and hierarchical multiple regressions with Bonferroni corrections. Analyses were conducted with and without adjusting for variance shared with substance use (cannabis, alcohol, tobacco) in the previous 90 days, and co-occurring mood, anxiety, and substance use diagnoses. Results and Conclusions: Compared to participants without PTSD, participants with PTSD reported significantly increased: (a) use of cannabis to cope, (b) severity of cannabis withdrawal, and (c) experiences of craving related to compulsivity, emotionality, and anticipation, with findings regarding coping and craving remaining significant after adjusting for covariates. Among the total sample, PTSD symptom severity was positively associated with (a) use of cannabis to cope, (b) cannabis use problems, (c) severity of cannabis withdrawal, and (d) experiences of craving related to compulsivity and emotionality, with findings regarding withdrawal and emotion-related craving remaining significant after adjusting for covariates. Thus, links between PTSD and using cannabis to cope, severity of cannabis withdrawal, and especially craving appear robust across measures of PTSD and analytical method. Scientific Significance: The results of this study provide support for models that posit a pernicious feedback loop between PTSD symptomatology and cannabis use. Adapted from the source document. JF - The American Journal on Addictions AU - Boden, Matthew Tyler AU - Babson, Kimberly A AU - Vujanovic, Anka A AU - Short, Nicole A AU - Bonn-Miller, Marcel O AD - 795 Willow Road (152-MPD), Menlo Park, CA 94025 Y1 - 2013/05// PY - 2013 DA - May 2013 SP - 277 EP - 284 PB - Wiley Subscription Services, Inc. VL - 22 IS - 3 SN - 1055-0496, 1055-0496 KW - Craving KW - Symptoms KW - Severity KW - Posttraumatic stress disorder KW - Cannabis KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1373488453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+on+Addictions&rft.atitle=Posttraumatic+Stress+Disorder+and+Cannabis+Use+Characteristics+among+Military+Veterans+with+Cannabis+Dependence&rft.au=Boden%2C+Matthew+Tyler%3BBabson%2C+Kimberly+A%3BVujanovic%2C+Anka+A%3BShort%2C+Nicole+A%3BBonn-Miller%2C+Marcel+O&rft.aulast=Boden&rft.aufirst=Matthew&rft.date=2013-05-01&rft.volume=22&rft.issue=3&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+on+Addictions&rft.issn=10550496&rft_id=info:doi/10.1111%2Fj.1521-0391.2012.12018.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cannabis; Posttraumatic stress disorder; Craving; Severity; Substance abuse; Symptoms DO - http://dx.doi.org/10.1111/j.1521-0391.2012.12018.x ER - TY - JOUR T1 - A Retrospective, Empirical Study of Grief-Related Beliefs in a Veterans Affairs Medical Center AN - 1494299523; 201400793 AB - This article reports on the findings of a retrospective, empirical study that explores and describes grief-related beliefs of a convenience sample of 312 persons in a Veterans hospital. These beliefs may facilitate bereaved individuals' emotional regulation and adaptive responses to loss conceptualized in the dual process model. The study addresses the question: Do gender, employment status, and loss burden contribute to differences in grief-related beliefs? The findings reveal significant gender differences, and also that grief-related beliefs are reality rather than myth-oriented. Study limitations and implications for social work practice in bereavement care and hospice settings are discussed. Adapted from the source document. JF - Smith College Studies in Social Work AU - Sexton, Charlene A AD - Robley Rex Veterans Affairs Medical Center, Louisville, Kentucky, USA charlene.sexton@va.gov Y1 - 2013/04// PY - 2013 DA - April 2013 SP - 249 EP - 278 PB - Taylor & Francis, Philadelphia PA VL - 83 IS - 2-3 SN - 0037-7317, 0037-7317 KW - Veterans KW - Hospices KW - Sex Differences KW - Medicine KW - Beliefs KW - Grief KW - Self Control KW - Sex KW - Hospitals KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1494299523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Smith+College+Studies+in+Social+Work&rft.atitle=A+Retrospective%2C+Empirical+Study+of+Grief-Related+Beliefs+in+a+Veterans+Affairs+Medical+Center&rft.au=Sexton%2C+Charlene+A&rft.aulast=Sexton&rft.aufirst=Charlene&rft.date=2013-04-01&rft.volume=83&rft.issue=2-3&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Smith+College+Studies+in+Social+Work&rft.issn=00377317&rft_id=info:doi/10.1080%2F00377317.2013.802641 LA - English DB - Social Services Abstracts N1 - Date revised - 2014-02-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SMSWAW N1 - SubjectsTermNotLitGenreText - Veterans; Hospitals; Grief; Beliefs; Sex; Sex Differences; Hospices; Self Control; Medicine DO - http://dx.doi.org/10.1080/00377317.2013.802641 ER - TY - JOUR T1 - Assessment of capacity in an aging society. AN - 1449097576; 201324389 AB - Over the past 40 years, the assessment and scientific study of capacity in older adults has emerged as a distinct field of clinical and research activity for psychologists. This new field reflects the convergence of several trends: the aging of American society, the growing incidence and prevalence of dementia, and the patient rights, deinstitutionalization, and disability rights movements. Because of these forces, capacity issues now permeate the fabric of everyday life, whether in the form of guardianship petitions, questions of capacity to consent to treatment, the ability to make a new will, or participation in human research. In seeking to resolve these issues, families, clinicians, and legal professionals increasingly turn to psychologists to assess a capacity and to provide empirically supported judgments that properly balance autonomy and protection for the individual. Psychologists have taken a leading role in the development of functional assessment instruments that measure important aspects of the capacity construct. In addition, psychology has been a major contributor to the scientific study of capacity. In collaboration with colleagues from medicine and law, psychologists have articulated crucial theoretical frameworks that integrate legal, clinical, and ethical dimensions of the capacity problem. This article focuses on the evolution of theory, law, science, and practice in the evaluation of capacity in older adults and its recent culmination in a series of interdisciplinary handbooks sponsored by the American Psychological Association and the American Bar Association. [Copyright The American Psychological Association.] JF - American Psychologist AU - Moye, Jennifer AU - Marson, Daniel C AU - Edelstein, Barry Y1 - 2013/04// PY - 2013 DA - April 2013 SP - 158 EP - 171 PB - American Psychological Association, Washington DC VL - 68 IS - 3 SN - 0003-066X, 0003-066X KW - assessment KW - capacity KW - competency KW - decision making KW - informed consent KW - aging society KW - Ageing KW - Elderly people KW - American Psychological Association KW - Psychologists KW - Disability rights movements KW - Clinical psychologists KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1449097576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Psychologist&rft.atitle=Assessment+of+capacity+in+an+aging+society.&rft.au=Moye%2C+Jennifer%3BMarson%2C+Daniel+C%3BEdelstein%2C+Barry&rft.aulast=Moye&rft.aufirst=Jennifer&rft.date=2013-04-01&rft.volume=68&rft.issue=3&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=American+Psychologist&rft.issn=0003066X&rft_id=info:doi/10.1037%2Fa0032159 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Clinical psychologists; Ageing; Psychologists; Elderly people; American Psychological Association; Disability rights movements DO - http://dx.doi.org/10.1037/a0032159 ER - TY - JOUR T1 - Comorbid Posttraumatic Stress Disorder and Opiate Addiction: A Literature Review AN - 1438666337; 201320870 AB - Treatment of comorbid posttraumatic stress disorder (PTSD) and opioid dependence has been a challenge for many clinicians. There are limited evidence-based guidelines for treatment of this comorbidity. Symptoms of PTSD and opiate dependence may converge, and it is sometimes difficult to differentiate between both conditions. For example, opioid withdrawal symptoms may mimic the hypervigilance and exacerbated startle response of patients with PTSD. A common neurobiologic circuit is suggested for the pathophysiologic mechanism of this comorbidity. There is evidence that opioid substitution therapy may improve treatment outcomes for opioid addiction in patients with comorbid PTSD and opioid dependence. Evidence-based psychotherapeutic intervention is recommended for this population to improve the psychological outcome as well. Combining opioid substitution therapy with evidence-based cognitive behavioral therapy designed for individuals with comorbid PTSD and substance abuse (e.g., Seeking Safety) may improve treatment outcomes in this population. More research is needed to understand the underlying mechanisms for this comorbidity and to improve treatment response. Adapted from the source document. JF - Journal of Addictive Diseases AU - Fareed, Ayman AU - Eilender, Pamela AU - Haber, Michael AU - Bremner, James AU - Whitfield, Natasha AU - Drexler, Karen AD - Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA ayman.fareed@va.gov Y1 - 2013/04// PY - 2013 DA - April 2013 SP - 168 EP - 179 PB - Taylor & Francis, Philadelphia PA VL - 32 IS - 2 SN - 1055-0887, 1055-0887 KW - Clinical outcomes KW - Posttraumatic stress disorder KW - Psychotherapy KW - Opioids KW - Drug dependency KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438666337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Addictive+Diseases&rft.atitle=Comorbid+Posttraumatic+Stress+Disorder+and+Opiate+Addiction%3A+A+Literature+Review&rft.au=Fareed%2C+Ayman%3BEilender%2C+Pamela%3BHaber%2C+Michael%3BBremner%2C+James%3BWhitfield%2C+Natasha%3BDrexler%2C+Karen&rft.aulast=Fareed&rft.aufirst=Ayman&rft.date=2013-04-01&rft.volume=32&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Journal+of+Addictive+Diseases&rft.issn=10550887&rft_id=info:doi/10.1080%2F10550887.2013.795467 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDER N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Comorbidity; Opioids; Drug dependency; Psychotherapy; Clinical outcomes DO - http://dx.doi.org/10.1080/10550887.2013.795467 ER - TY - JOUR T1 - Association between exercise and primary incidence of prostate cancer AN - 1434015706; 18486941 AB - BACKGROUND: Exercise is a modifiable lifestyle risk factor associated with prostate cancer risk reduction. However, whether this association is different as a function of race is unclear. In the current study, the authors attempted to characterize the link between exercise and prostate cancer (CaP) in white and black American men. METHODS: Using a prospective design, 307 men (164 of whom were white and 143 of whom were black) who were undergoing prostate biopsy completed a self-reported survey that assessed exercise behavior (metabolic equivalent [MET] hours per week). Crude and adjusted logistic regression analyses were used to estimate the risk of prostate cancer controlling for age, body mass index, digital rectal examination findings, previous biopsy, Charlson comorbidity score, and family history of CaP stratified by self-reported race. RESULTS: There was no significant difference noted with regard to the amount of exercise between racial groups (P = .12). Higher amounts of MET hours per week were associated with a decreased risk of CaP for white men in both crude (P = .02) and adjusted (P = .04) regression models. Among whites, men who exercised greater than or equal to 9 MET hours per week were less likely to have a positive biopsy result compared with men exercising < 9 MET hours per week (odds ratio, 0.47; 95% confidence interval, 0.22-0.99 [P = .047]). There was no association noted between MET hours per week and risk of CaP among black men in both crude (P = .79) and adjusted (P = .76) regression models. CONCLUSIONS: In a prospective cohort of men undergoing biopsy, increased exercise, measured as MET hours per week, was found to be associated with CaP risk reduction among white but not black men. Investigating race-specific mechanisms by which exercise modifies CaP risk and why these mechanisms disfavor black men in particular are warranted. Cancer 2013. [copy 2013 American Cancer Society. In a prospective cohort of men undergoing biopsy, an increased amount of exercise was associated with a risk reduction for prostate cancer in white men but not black men. White men who exercised greater than or equal to 9 metabolic equivalent (MET) hours per week were less likely to have a positive biopsy compared with men exercising < 9 MET hours per week (odds ratio, 0.47; P = .047). JF - Cancer AU - Singh, Abhay A AU - Jones, Lee W AU - Antonelli, Jodi A AU - Gerber, Leah AU - Calloway, Elizabeth E AU - Shuler, Kathleen H AU - Freedland, Stephen J AU - Grant, Delores J AU - Hoyo, Cathrine AU - Banez, Lionel L AD - Duke Prostate Center, Duke University Medical Center, Durham, North Carolina., lionel.banez@va.gov Y1 - 2013/04// PY - 2013 DA - Apr 2013 SP - 1338 EP - 1343 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 119 IS - 7 SN - 0008-543X, 0008-543X KW - Risk Abstracts KW - Health risks KW - Genetics KW - Age KW - Prostate cancer KW - Risk factors KW - Body mass KW - Risk reduction KW - Cancer KW - Morbidity KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1434015706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Association+between+exercise+and+primary+incidence+of+prostate+cancer&rft.au=Singh%2C+Abhay+A%3BJones%2C+Lee+W%3BAntonelli%2C+Jodi+A%3BGerber%2C+Leah%3BCalloway%2C+Elizabeth+E%3BShuler%2C+Kathleen+H%3BFreedland%2C+Stephen+J%3BGrant%2C+Delores+J%3BHoyo%2C+Cathrine%3BBanez%2C+Lionel+L&rft.aulast=Singh&rft.aufirst=Abhay&rft.date=2013-04-01&rft.volume=119&rft.issue=7&rft.spage=1338&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.27791 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-09-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Genetics; Health risks; Age; Prostate cancer; Body mass; Risk factors; Risk reduction; Morbidity; Cancer DO - http://dx.doi.org/10.1002/cncr.27791 ER - TY - JOUR T1 - Identification and Treatment of TBI and Co-occurring Psychiatric Symptoms Among OEF/OIF/OND Veterans Seeking Mental Health Services Within the State of Colorado: Establishing Consensus for Best Practices AN - 1430189724; 201319072 AB - This paper highlights the results of a consensus meeting regarding best practices for the assessment and treatment of co-occurring traumatic brain injury (TBI) and mental health (MH) problems among Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn Veterans seeking care in non-Veterans Affairs Colorado community MH settings. Twenty individuals with expertise in TBI screening, assessment, and intervention, as well as the state MH system, convened to establish and review questions and assumptions regarding care for this Veteran population. Unanimous consensus regarding best practices was achieved. Recommendations for improving care for Veterans seeking care in community MH settings are provided. Adapted from the source document. JF - Community Mental Health Journal AU - Olson-Madden, Jennifer H AU - Brenner, Lisa A AU - Matarazzo, Bridget B AU - Signoracci, Gina M AD - Veterans Integrated Service Network (VISN) 19, Mental Illness Research, Education, and Clinical Center (MIRECC), 1055 Clermont Street, Denver, CO, 80220, USA jennifer.olson-madden@va.gov Y1 - 2013/04// PY - 2013 DA - April 2013 SP - 220 EP - 229 PB - Springer, Dordrecht The Netherlands VL - 49 IS - 2 SN - 0010-3853, 0010-3853 KW - Assessment KW - Veterans KW - Best practice KW - Expertise KW - Freedom KW - Traumatic brain injury KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1430189724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Identification+and+Treatment+of+TBI+and+Co-occurring+Psychiatric+Symptoms+Among+OEF%2FOIF%2FOND+Veterans+Seeking+Mental+Health+Services+Within+the+State+of+Colorado%3A+Establishing+Consensus+for+Best+Practices&rft.au=Olson-Madden%2C+Jennifer+H%3BBrenner%2C+Lisa+A%3BMatarazzo%2C+Bridget+B%3BSignoracci%2C+Gina+M&rft.aulast=Olson-Madden&rft.aufirst=Jennifer&rft.date=2013-04-01&rft.volume=49&rft.issue=2&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-012-9572-4 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CMHJAY N1 - SubjectsTermNotLitGenreText - Veterans; Best practice; Freedom; Assessment; Expertise; Traumatic brain injury DO - http://dx.doi.org/10.1007/s10597-012-9572-4 ER - TY - JOUR T1 - "Strength at Home" Group Intervention for Military Populations Engaging in Intimate Partner Violence: Pilot Findings AN - 1429631064; 201338935 AB - In this brief report, we present information on the Strength at Home intervention to treat male active duty or military veteran perpetrators of intimate partner violence (IPV) as well as preliminary pilot study findings. Strength at Home is a 12-session cognitive-behavioral group intervention developed by the authors that is based on a social information processing model of IPV perpetration. Six men referred to two intervention groups and five collateral female partners participated in this pilot study. Findings indicated large reductions for most indices of physical and psychological IPV from pre-treatment to 6-month follow-up. These initial results are promising though the small sample size and other study limitations preclude our ability to draw firm conclusions. Adapted from the source document. JF - Journal of Family Violence AU - Taft, Casey T AU - Macdonald, Alexandra AU - Monson, Candice M AU - Walling, Sherry M AU - Resick, Patricia A AU - Murphy, Christopher M AD - Veterans Affairs Boston Healthcare System (116B-4), 150 South Huntington Avenue, Boston, MA, 02130, USA casey.taft@va.gov Y1 - 2013/04// PY - 2013 DA - April 2013 SP - 225 EP - 231 PB - Springer Science+Business Media, Inc, New York, NY VL - 28 IS - 3 SN - 0885-7482, 0885-7482 KW - Veterans KW - Partner Abuse KW - Males KW - Intervention KW - Females KW - Armed Forces KW - Social Learning KW - article KW - 2190: social problems and social welfare; victimology (rape, family violence, & child abuse) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1429631064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Violence&rft.atitle=%22Strength+at+Home%22+Group+Intervention+for+Military+Populations+Engaging+in+Intimate+Partner+Violence%3A+Pilot+Findings&rft.au=Taft%2C+Casey+T%3BMacdonald%2C+Alexandra%3BMonson%2C+Candice+M%3BWalling%2C+Sherry+M%3BResick%2C+Patricia+A%3BMurphy%2C+Christopher+M&rft.aulast=Taft&rft.aufirst=Casey&rft.date=2013-04-01&rft.volume=28&rft.issue=3&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Violence&rft.issn=08857482&rft_id=info:doi/10.1007%2Fs10896-013-9496-y LA - English DB - Sociological Abstracts N1 - Date revised - 2013-09-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JFVIEV N1 - SubjectsTermNotLitGenreText - Intervention; Males; Partner Abuse; Armed Forces; Females; Social Learning; Veterans DO - http://dx.doi.org/10.1007/s10896-013-9496-y ER - TY - JOUR T1 - Substance Use Among Women Veterans: Epidemiology to Evidence-Based Treatment AN - 1427001429; 18330715 AB - An increasing percentage of women are U.S. Military Veterans. We review the substance misuse rates and comorbidities and the risk factors for and consequences of substance use among women Veterans. Women Veterans may have higher rates of substance misuse and comorbid psychiatric and medical disorders than male Veterans and women who are not Veterans. Studies support the AUDIT-C as a scaled marker of alcohol-related risk among female Veterans, but validated drug screening instruments are needed. We discuss evidence-based approaches in terms of treating women Veterans' substance misuse in primary and specialty care settings, along with knowledge gaps and potential research priorities to improve care in this special population. JF - Journal of Addictive Diseases AU - Cucciare, Michael A AU - Simpson, Tracy AU - Hoggatt, Katherine J AU - Gifford, Elizabeth AU - Timko, Christine AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, Menlo Park, California, USA, michael.cucciare@va.gov Y1 - 2013/04/01/ PY - 2013 DA - 2013 Apr 01 SP - 119 EP - 139 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 2 SN - 1055-0887, 1055-0887 KW - Risk Abstracts KW - USA KW - Epidemiology KW - Reviews KW - Risk factors KW - Priorities KW - Females KW - Military KW - Substance use KW - Drugs KW - Morbidity KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1427001429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Addictive+Diseases&rft.atitle=Substance+Use+Among+Women+Veterans%3A+Epidemiology+to+Evidence-Based+Treatment&rft.au=Cucciare%2C+Michael+A%3BSimpson%2C+Tracy%3BHoggatt%2C+Katherine+J%3BGifford%2C+Elizabeth%3BTimko%2C+Christine&rft.aulast=Cucciare&rft.aufirst=Michael&rft.date=2013-04-01&rft.volume=32&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Journal+of+Addictive+Diseases&rft.issn=10550887&rft_id=info:doi/10.1080%2F10550887.2013.795465 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-08-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Epidemiology; Risk factors; Reviews; Priorities; Females; Military; Drugs; Substance use; Morbidity; USA DO - http://dx.doi.org/10.1080/10550887.2013.795465 ER - TY - JOUR T1 - Professional Comportment: The Missing Element in Nursing Practice AN - 1373490810; 201312543 AB - The aim of this concept analysis of professional comportment is to elucidate the dimension of nursing practice that fosters cooperation, collaboration, effective communication, and team cohesion among nurses. Professional comportment is a concept that has not been developed or analyzed, and its integration into nursing practice is unclear and not specified. The body of knowledge concentrating on the spectrum of professional comportment, civility, and lateral violence is presently incomplete. Analyzing and developing the concept of professional comportment will satisfy a gap in the literature. A concept analysis of professional comportment will clarify for the nurse the power of words, behaviors, and communication needed to achieve effective communication and civility. The Walker and Avant framework for concept analysis was used to analyze the concept of professional comportment. An electronic review of the literature through the Cumulative Index to Nursing and Allied Health Literature, Health Sources, Medical Complete, and ProQuest was conducted. This review rendered approximately 300 articles, of which 85 were reviewed. Eighteen articles informed comportment as a definition and are utilized in this analysis. The individual nurse is the level of focus in the analysis, not the organizational culture. Comportment is defined as a dignified manner or conduct. Professional comportment is critical in determining a nurse's effectiveness in relating, communicating, and collaborating with colleagues and members of the healthcare team. In the absence of professional comportment, a culture of incivility, nurse aggression, and compromised patient safety will emerge. Self-regulation and individual accountability are sequelae to professional comportment. The personal assimilation of professional comportment promotes mutual respect, harmony, commitment, and collaboration. The nurse, patient, and healthcare team are the beneficiaries of a nurse who demonstrates professional comportment. Adapted from the source document. JF - Nursing Forum AU - Clickner, Deborah A AU - Shirey, Maria R AD - Providence Veterans Administration Medical Center Y1 - 2013/04// PY - 2013 DA - April 2013 SP - 106 EP - 113 PB - Wiley-Blackwell, UK VL - 48 IS - 2 SN - 0029-6473, 0029-6473 KW - Teams KW - Nursing KW - Concept analysis KW - Nurses KW - Professional practices KW - Civility KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1373490810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Forum&rft.atitle=Professional+Comportment%3A+The+Missing+Element+in+Nursing+Practice&rft.au=Clickner%2C+Deborah+A%3BShirey%2C+Maria+R&rft.aulast=Clickner&rft.aufirst=Deborah&rft.date=2013-04-01&rft.volume=48&rft.issue=2&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Nursing+Forum&rft.issn=00296473&rft_id=info:doi/10.1111%2Fnuf.12014 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nurses; Nursing; Teams; Professional practices; Concept analysis; Civility DO - http://dx.doi.org/10.1111/nuf.12014 ER - TY - JOUR T1 - Does Providing Care for Uninsured Patients Decrease Emergency Room Visits and Hospitalizations? AN - 1364765826; 201310305 AB - Background: Access to primary care could reduce use of more costly health care by uninsured individuals through prevention and early treatment. We analyzed data from a program providing free primary care to test this hypothesis. Methods: We compared emergency room (ER) visits and hospitalizations among uninsured, low-income adults who received immediate versus delayed access to a program providing free primary care, including labs, X-rays, and specialty consultation. We used surveys to identify ER visits and hospitalizations during the 12 months preceding and following program enrollment or wait list entry. Results: Hospitalizations decreased from the year before entry to the year following entry in participants with immediate and delayed (6.0% vs 8.8% decrease) access. ER use also decreased in both groups (11.2% vs 15.4%). Conclusions: Free primary care services and specialty consultation did not reduce use of more costly health care services during its first year. More prolonged availability of primary care might have greater impact. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Journal of Primary Care & Community Health AU - MacKinney, Ted AU - Visotcky, Alexis M AU - Tarima, Sergey AU - Whittle, Jeff AD - Department of Medicine, Division of General Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, USA Y1 - 2013/04// PY - 2013 DA - April 2013 SP - 135 EP - 142 PB - Sage Publications, Thousand Oaks CA VL - 4 IS - 2 SN - 2150-1319, 2150-1319 KW - community health, health outcomes, impact evaluation, primary care, program evaluation KW - Health costs KW - Delayed KW - Hospitalization KW - Consultation KW - Uninsured patients KW - Primary health care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1364765826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Primary+Care+%26+Community+Health&rft.atitle=Does+Providing+Care+for+Uninsured+Patients+Decrease+Emergency+Room+Visits+and+Hospitalizations%3F&rft.au=MacKinney%2C+Ted%3BVisotcky%2C+Alexis+M%3BTarima%2C+Sergey%3BWhittle%2C+Jeff&rft.aulast=MacKinney&rft.aufirst=Ted&rft.date=2013-04-01&rft.volume=4&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Primary+Care+%26+Community+Health&rft.issn=21501319&rft_id=info:doi/10.1177%2F2150131913478981 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Primary health care; Hospitalization; Uninsured patients; Consultation; Health costs; Delayed DO - http://dx.doi.org/10.1177/2150131913478981 ER - TY - JOUR T1 - Characteristics of 161-km Ultramarathon Finishers Developing Exercise-Associated Hyponatremia AN - 1348483356; 17881268 AB - This study sought to identify runner characteristics or symptoms that could distinguish those finishers developing exercise-associated hyponatremia (EAH) from those not developing EAH in a 161-km ultramarathon. Of 310 finishers, 207 (67%) underwent postrace blood studies. Twelve (6%) finishers had EAH (blood sodium range 131-134 mmol/L). Experience at 161-km ultramarathons was lower (p = 0.01) and blood creatine kinase (CK) concentration was higher (p = 0.04) among those with EAH than those not developing EAH. Blood sodium and CK concentration were negatively correlated (p = 0.0015, r = -0.22). There were no group differences in age, sex, regular running experience, weekly training distance, use of sodium supplements during training, immediately postrace sodium palatability and thirst ratings, body mass change, urination frequency, nonsteroidal anti-inflammatory drugs (NSAIDs) use, and various symptoms experienced during the race. These findings indicate that a clinical suspicion and measurement of blood sodium concentration remain the only viable means for determining when an ultramarathon runner has EAH. JF - Research in Sports Medicine AU - Hoffman, Martin D AU - Fogard, Kevin AU - Winger, James AU - Hew-Butler, Tamara AU - Stuempfle, Kristin J AD - Department of Physical Medicine & Rehabilitation, Department of Veterans Affairs, Northern California Health Care System, Sacramento, California, USA, martin.hoffman@va.gov Y1 - 2013/04/01/ PY - 2013 DA - 2013 Apr 01 SP - 164 EP - 175 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 21 IS - 2 SN - 1543-8627, 1543-8627 KW - Physical Education Index KW - Blood KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1348483356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Sports+Medicine&rft.atitle=Characteristics+of+161-km+Ultramarathon+Finishers+Developing+Exercise-Associated+Hyponatremia&rft.au=Hoffman%2C+Martin+D%3BFogard%2C+Kevin%3BWinger%2C+James%3BHew-Butler%2C+Tamara%3BStuempfle%2C+Kristin+J&rft.aulast=Hoffman&rft.aufirst=Martin&rft.date=2013-04-01&rft.volume=21&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Research+in+Sports+Medicine&rft.issn=15438627&rft_id=info:doi/10.1080%2F15438627.2012.757230 LA - English DB - Physical Education Index N1 - Date revised - 2013-05-01 N1 - Last updated - 2014-03-10 N1 - SubjectsTermNotLitGenreText - Blood DO - http://dx.doi.org/10.1080/15438627.2012.757230 ER - TY - JOUR T1 - Adalimumab therapy for refractory uveitis: results of a multicentre, open-label, prospective trial. AN - 1318094325; 23376607 AB - Tumour necrosis factor (TNF) blockers have been demonstrated to be effective in the treatment of systemic and ocular inflammatory diseases. We conducted a prospective, multicentre, open-label Phase II clinical trial to assess the effectiveness and safety of adalimumab, a fully human anti-TNF monoclonal antibody, in treating refractory uveitis. Subjects with non-infectious uveitis refractory to corticosteroids and at least one other immunosuppressive medication were enrolled. Treatment outcome was ascertained by a composite endpoint comprised of visual acuity, intraocular inflammation, ability to taper immunosuppressives, and posterior segment imaging. Clinical response was defined by improvement in at least one parameter, worsening in none, and well controlled intraocular inflammation. Week 10 responders were permitted to continue receiving adalimumab for the study duration of 50 weeks. Twenty-one of 31 patients (68%) were characterised as clinical responders at 10 weeks, of whom 12 patients (39%) exhibited durable response after 50 weeks. The most common reason for study termination was primary or secondary inefficacy. No patients experienced treatment-limiting toxicity clearly related to study therapy. Adalimumab was safe and effective in 68% of refractory uveitis patients 10 weeks after study enrolment, and maintained in 39% after 1 year. Ongoing study is required to determine the place of adalimumab and other TNF blockers in the treatment of uveitis. JF - The British journal of ophthalmology AU - Suhler, Eric B AU - Lowder, Careen Y AU - Goldstein, Debra A AU - Giles, Tracy AU - Lauer, Andreas K AU - Kurz, Paul A AU - Pasadhika, Sirichai AU - Lee, Shelly T AU - de Saint Sardos, Alexandre AU - Butler, Nicholas J AU - Tessler, Howard H AU - Smith, Justine R AU - Rosenbaum, James T AD - Portland Veterans Administration Medical Center, Portland, Oregon, USA. suhlere@ohsu.edu Y1 - 2013/04// PY - 2013 DA - April 2013 SP - 481 EP - 486 VL - 97 IS - 4 KW - Anti-Inflammatory Agents KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Glucocorticoids KW - Immunosuppressive Agents KW - Tumor Necrosis Factor-alpha KW - Adalimumab KW - FYS6T7F842 KW - Index Medicus KW - Young Adult KW - Humans KW - Fluorescein Angiography KW - Aged KW - Drug Resistance KW - Visual Acuity -- physiology KW - Prospective Studies KW - Adult KW - Treatment Outcome KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors KW - Middle Aged KW - Tomography, Optical Coherence KW - Glucocorticoids -- therapeutic use KW - Immunosuppressive Agents -- therapeutic use KW - Female KW - Male KW - Antibodies, Monoclonal, Humanized -- adverse effects KW - Antibodies, Monoclonal, Humanized -- therapeutic use KW - Anti-Inflammatory Agents -- adverse effects KW - Anti-Inflammatory Agents -- therapeutic use KW - Uveitis -- diagnosis KW - Uveitis -- physiopathology KW - Uveitis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1318094325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+ophthalmology&rft.atitle=Adalimumab+therapy+for+refractory+uveitis%3A+results+of+a+multicentre%2C+open-label%2C+prospective+trial.&rft.au=Suhler%2C+Eric+B%3BLowder%2C+Careen+Y%3BGoldstein%2C+Debra+A%3BGiles%2C+Tracy%3BLauer%2C+Andreas+K%3BKurz%2C+Paul+A%3BPasadhika%2C+Sirichai%3BLee%2C+Shelly+T%3Bde+Saint+Sardos%2C+Alexandre%3BButler%2C+Nicholas+J%3BTessler%2C+Howard+H%3BSmith%2C+Justine+R%3BRosenbaum%2C+James+T&rft.aulast=Suhler&rft.aufirst=Eric&rft.date=2013-04-01&rft.volume=97&rft.issue=4&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+ophthalmology&rft.issn=1468-2079&rft_id=info:doi/10.1136%2Fbjophthalmol-2012-302292 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-05-15 N1 - Date created - 2013-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/bjophthalmol-2012-302292 ER - TY - JOUR T1 - Alcohol problems as a risk factor for postdisaster depressed mood among U.S. veterans. AN - 1449098779; 201323674 AB - Alcohol problems may impede adaptive, proactive responses to disaster-related injury and loss, thus prolonging the adverse impact of disasters on mental health. Previous work suggests that veterans of the U.S. armed forces have a relatively high prevalence of alcohol misuse and other psychiatric disorders. This is the first study to estimate the impact of predisaster alcohol problems on postdisaster depressed mood among veterans, using data that were collected before and after the 1994 Northridge, CA, earthquake. The authors assessed the impact of alcohol problems on postdisaster depressed mood in an existing clinical cohort of veterans who experienced the 6.7-magnitude earthquake that struck Northridge in January 1994. One to 3 months after the disaster, interviewers contacted participants by telephone to administer a follow-up questionnaire based on a survey that had been done preearthquake. Postearthquake data were obtained on 1,144 male veterans for whom there were preearthquake data. We tested a predictive path model of the relationships between latent variables for predisaster alcohol problems, functional limitations, and depressed mood on latent variables representing postdisaster "quake impact" and depressive mood. Results showed that veterans who had more alcohol problems before the earthquake experienced more earthquake-related harms and severely depressed mood after the earthquake, compared with those who had fewer alcohol problems. Programs serving veterans with a high prevalence of alcohol problems should consider designing disaster response protocols to locate and assist these patients in the aftermath of disasters. [Copyright The American Psychological Association.] JF - Psychology of Addictive Behaviors AU - Heslin, Kevin C AU - Stein, Judith A AU - Dobalian, Aram AU - Simon, Barbara AU - Lanto, Andrew B AU - Yano, Elizabeth M AU - Rubenstein, Lisa V Y1 - 2013/03// PY - 2013 DA - March 2013 SP - 207 EP - 213 PB - American Psychological Association, Washington DC VL - 27 IS - 1 SN - 0893-164X, 0893-164X KW - alcohol KW - disasters KW - longitudinal studies KW - mental health KW - structural equation modeling KW - risk factors KW - depressed mood KW - veterans KW - alcohol problems KW - Earthquakes KW - Veterans KW - Alcohol abuse KW - Disasters KW - Moods KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1449098779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Addictive+Behaviors&rft.atitle=Alcohol+problems+as+a+risk+factor+for+postdisaster+depressed+mood+among+U.S.+veterans.&rft.au=Heslin%2C+Kevin+C%3BStein%2C+Judith+A%3BDobalian%2C+Aram%3BSimon%2C+Barbara%3BLanto%2C+Andrew+B%3BYano%2C+Elizabeth+M%3BRubenstein%2C+Lisa+V&rft.aulast=Heslin&rft.aufirst=Kevin&rft.date=2013-03-01&rft.volume=27&rft.issue=1&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/10.1037%2Fa0030637 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PABEEI N1 - SubjectsTermNotLitGenreText - Alcohol abuse; Veterans; Moods; Earthquakes; Disasters; Prevalence DO - http://dx.doi.org/10.1037/a0030637 ER - TY - JOUR T1 - Survey of providers' attitudes toward integrating smoking cessation treatment into posttraumatic stress disorder care. AN - 1449095916; 201324212 AB - A survey was administered anonymously to 45 mental health providers who delivered smoking cessation treatment integrated into posttraumatic stress disorder care (integrated care) as part of a multisite clinical trial. Survey items assessed key factors associated with successful implementation of research-based practices from the perspective of treating providers. Factors assessed included prior experiences with cessation treatment, compatibility of integrated care with current practices, feasibility of adopting integrated care into regular practice, and adequacy of training. More than half of respondents reported that integrated care delivery was feasible, and they would be considerably or extremely likely to continue delivery in routine practice. Positive prestudy beliefs and more experience delivering cessation care were associated with stronger endorsement of delivering integrated care after the study. The most frequently cited obstacle to delivering integrated care involved time limitations. Future efforts should focus on developing treatment adaptations that address provider-identified barriers and identifying clinic- and administrative-level supports that facilitate delivery of integrated care and assist providers who incorporate integrated care into clinical practice. [Copyright The American Psychological Association.] JF - Psychology of Addictive Behaviors AU - Malte, Carol A AU - McFall, Miles AU - Chow, Bruce AU - Beckham, Jean C AU - Carmody, Timothy P AU - Saxon, Andrew J Y1 - 2013/03// PY - 2013 DA - March 2013 SP - 249 EP - 255 PB - American Psychological Association, Washington DC VL - 27 IS - 1 SN - 0893-164X, 0893-164X KW - implementation KW - mental health providers KW - posttraumatic stress disorder KW - provider survey KW - smoking cessation KW - veterans KW - Smoking KW - Attitudes KW - Posttraumatic stress disorder KW - Care delivery KW - Integrated services KW - Cessation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1449095916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Addictive+Behaviors&rft.atitle=Survey+of+providers%27+attitudes+toward+integrating+smoking+cessation+treatment+into+posttraumatic+stress+disorder+care.&rft.au=Malte%2C+Carol+A%3BMcFall%2C+Miles%3BChow%2C+Bruce%3BBeckham%2C+Jean+C%3BCarmody%2C+Timothy+P%3BSaxon%2C+Andrew+J&rft.aulast=Malte&rft.aufirst=Carol&rft.date=2013-03-01&rft.volume=27&rft.issue=1&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/10.1037%2Fa0028484 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PABEEI N1 - SubjectsTermNotLitGenreText - Integrated services; Cessation; Care delivery; Posttraumatic stress disorder; Smoking; Attitudes DO - http://dx.doi.org/10.1037/a0028484 ER - TY - JOUR T1 - Patient Experiences With Full Electronic Access to Health Records and Clinical Notes Through the My HealtheVet Personal Health Record Pilot: Qualitative Study AN - 1373422264; 201306506 AB - Background: Full sharing of the electronic health record with patients has been identified as an important opportunity to engage patients in their health and health care. The My HealtheVet Pilot, the initial personal health record of the US Department of Veterans Affairs, allowed patients and their delegates to view and download content in their electronic health record, including clinical notes, laboratory tests, and imaging reports. Objective: A qualitative study with purposeful sampling sought to examine patients' views and experiences with reading their health records, including their clinical notes, online. Methods: Five focus group sessions were conducted with patients and family members who enrolled in the My HealtheVet Pilot at the Portland Veterans Administration Medical Center, Oregon. A total of 30 patients enrolled in the My HealtheVet Pilot, and 6 family members who had accessed and viewed their electronic health records participated in the sessions. Results: Four themes characterized patient experiences with reading the full complement of their health information. Patients felt that seeing their records positively affected communication with providers and the health system, enhanced knowledge of their health and improved self-care, and allowed for greater participation in the quality of their care such as follow-up of abnormal test results or decision-making on when to seek care. While some patients felt that seeing previously undisclosed information, derogatory language, or inconsistencies in their notes caused challenges, they overwhelmingly felt that having more, rather than less, of their health record information provided benefits. Conclusions: Patients and their delegates had predominantly positive experiences with health record transparency and the open sharing of notes and test results. Viewing their records appears to empower patients and enhance their contributions to care, calling into question common provider concerns about the effect of full record access on patient well-being. While shared records may or may not impact overall clinic workload, it is likely to change providers' work, necessitating new types of skills to communicate and partner with patients. Adapted from the source document. JF - Journal of Medical Internet Research AU - Woods, Susan S AU - Schwartz, Erin AU - Tuepker, Anais AU - Press, Nancy A AU - Nazi, Kim M AU - Turvey, Carolyn L AU - Nichol, W Paul AD - Portland VA Medical Center, Health Services Research & Development, Portland, OR susan.woods@va.gov Y1 - 2013/03// PY - 2013 DA - March 2013 PB - Gunther Eysenbach MD MPH, Associate Professor, University of Toronto Senior Scientist, Centre for Global eHealth Innovation, Toronto, Canada VL - 15 IS - 3 SN - 1438-8871, 1438-8871 KW - personal health records KW - eHealth KW - patient access to records KW - veterans KW - patient participation KW - Perceptions KW - Electronic medical records KW - Patients KW - Access to information KW - article KW - 10.13: INFORMATION COMMUNICATION - SCIENCE, TECHNOLOGY, MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1373422264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Internet+Research&rft.atitle=Patient+Experiences+With+Full+Electronic+Access+to+Health+Records+and+Clinical+Notes+Through+the+My+HealtheVet+Personal+Health+Record+Pilot%3A+Qualitative+Study&rft.au=Woods%2C+Susan+S%3BSchwartz%2C+Erin%3BTuepker%2C+Anais%3BPress%2C+Nancy+A%3BNazi%2C+Kim+M%3BTurvey%2C+Carolyn+L%3BNichol%2C+W+Paul&rft.aulast=Woods&rft.aufirst=Susan&rft.date=2013-03-01&rft.volume=15&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Internet+Research&rft.issn=14388871&rft_id=info:doi/10.2196%2Fjmir.2356 L2 - http://www.jmir.org/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2013-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Electronic medical records; Access to information; Patients; Perceptions DO - http://dx.doi.org/10.2196/jmir.2356 ER - TY - JOUR T1 - Trends in Opioid Agonist Therapy in the Veterans Health Administration: Is Supply Keeping up with Demand? AN - 1364703343; 201326773 AB - Background: Opioid agonist therapy (OAT) through addiction specialty clinic settings (clinic-based OAT) using methadone or buprenorphine or office-based settings using buprenorphine (office-based OAT) is an evidence-based treatment for opioid dependence. The low number of clinic-based OATs available to veterans (N = 53) presents a barrier to OAT access; thus, the expansion in office-based OAT has been encouraged. Objectives: To examine trends in office-based OAT utilization over time and whether availability of office-based OAT improved the proportion of veterans with opioid use disorders treated with OAT. Methods: We examined Veterans Health Administration (VHA) administrative data for evidence of buprenorphine prescribing and clinic-based OAT clinic stops from October 2003 through September 2010 [fiscal years (FY) 2004-2010]. Results: The number of patients receiving buprenorphine increased from 300 at 27 facilities in FY2004 to 6147 at 118 facilities in FY2010. During this time, the number of patients diagnosed with an opioid use disorder increased by 45%; however, the proportion of opioid use disorder patients receiving OAT remained relatively stable, ranging from 25% to 27%, Conclusions: Office-based OAT utilization and the number of opioid use disorder veterans treated with OAT are increasing at the same rate over time, suggesting that office-based OAT is being used to meet the growing need for OAT care. Although office-based OAT is increasingly being used within the VHA and may be one way the VHA is keeping up with the demand for OAT, more research is needed to understand how to engage a greater proportion of opioid use disorder patients in treatment. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Oliva, Elizabeth M AU - Trafton, Jodie A AU - Harris, Alex H.S. AU - Gordon, Adam J AD - Center for Health Care Evaluation, VA Palo Alto Health Care System, Menlo Park, CA, USA elizabeth.oliva@va.gov Y1 - 2013/03// PY - 2013 DA - March 2013 SP - 103 EP - 107 PB - Taylor & Francis Inc., Philadelphia, PA VL - 39 IS - 2 SN - 0095-2990, 0095-2990 KW - opioid agonist therapy, buprenorphine, veterans, office-based treatment, VA, VHA, methadone KW - Veterans KW - Opiates KW - Constraints KW - Evidence Based Practice KW - Health KW - Patients KW - Addiction KW - Trends KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1364703343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Trends+in+Opioid+Agonist+Therapy+in+the+Veterans+Health+Administration%3A+Is+Supply+Keeping+up+with+Demand%3F&rft.au=Oliva%2C+Elizabeth+M%3BTrafton%2C+Jodie+A%3BHarris%2C+Alex+H.S.%3BGordon%2C+Adam+J&rft.aulast=Oliva&rft.aufirst=Elizabeth&rft.date=2013-03-01&rft.volume=39&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.3109%2F00952990.2012.741167 LA - English DB - Sociological Abstracts N1 - Date revised - 2013-06-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Opiates; Veterans; Patients; Health; Addiction; Constraints; Evidence Based Practice; Trends DO - http://dx.doi.org/10.3109/00952990.2012.741167 ER - TY - JOUR T1 - Witnessed versus Unwitnessed Random Urine Tests in the Treatment of Opioid Dependence AN - 1347819079; 201306868 AB - Background and Objectives: Clinics licensed to provide pharmacotherapy for opiate dependence disorder are required to perform random urine drug screen (RUDS) tests. The results provide the empirical basis of individual treatment and programmatic effectiveness, and public health policy. Patients consent to witnessed testing but most tests are unwitnessed. The purpose of the present study was to compare treatment effectiveness estimates derived from witnessed versus unwitnessed urine samples. Methods: We adopted a policy requiring visually witnessed urine drug screens (WUDS) and studied its impact (a single group, pretest-posttest design) on the RUDS test results in 115 male veterans enrolled in the St. Louis VA Opioid Treatment Program. Results: The percentage of opioid-positive urine samples increased significantly following implementation of WUDS (25% vs. 41%, x2 = 66.5, p < .001). Conclusions and Scientific Significance: Results of this preliminary study suggest that random testing alone does not ensure the integrity of UDS testing. Outcome calculations based on random unwitnessed tests may overestimate the effectiveness of opioid dependence disorder treatment. Adapted from the source document. JF - The American Journal on Addictions AU - Mallya, Ashok AU - Purnell, Amanda L AU - Svrakic, Dragan M AU - Lovell, Ann M AU - Freedland, Kenneth E AU - Gott, Britt M AU - Sayuk, Gregory S AU - Cicero, Theodore J AU - Brawer, Peter A AU - Trafton, Jodie A AU - Scherrer, Jeffrey F AU - Lustman, Patrick J AD - Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid, Medical Box 8134, St. Louis, MO 63110 Y1 - 2013/03// PY - 2013 DA - March 2013 SP - 175 EP - 177 PB - Wiley Subscription Services, Inc. VL - 22 IS - 2 SN - 1055-0496, 1055-0496 KW - Urine KW - Urine tests KW - Clinics KW - St Louis KW - Treatment methods KW - Drug dependency KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1347819079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+on+Addictions&rft.atitle=Witnessed+versus+Unwitnessed+Random+Urine+Tests+in+the+Treatment+of+Opioid+Dependence&rft.au=Mallya%2C+Ashok%3BPurnell%2C+Amanda+L%3BSvrakic%2C+Dragan+M%3BLovell%2C+Ann+M%3BFreedland%2C+Kenneth+E%3BGott%2C+Britt+M%3BSayuk%2C+Gregory+S%3BCicero%2C+Theodore+J%3BBrawer%2C+Peter+A%3BTrafton%2C+Jodie+A%3BScherrer%2C+Jeffrey+F%3BLustman%2C+Patrick+J&rft.aulast=Mallya&rft.aufirst=Ashok&rft.date=2013-03-01&rft.volume=22&rft.issue=2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+on+Addictions&rft.issn=10550496&rft_id=info:doi/10.1111%2Fj.1521-0391.2013.00326.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Urine tests; Urine; Drug dependency; St Louis; Clinics; Treatment methods DO - http://dx.doi.org/10.1111/j.1521-0391.2013.00326.x ER - TY - JOUR T1 - Brief Motivational Feedback May Enhance Treatment Entry in Veterans with Comorbid Substance Use and Psychiatric Disorders AN - 1347817621; 201306824 AB - Background and Objectives: There are limited investigations of brief interventions to facilitate treatment entry among individuals with substance use disorders. This study investigated the effectiveness of brief motivational feedback (BMF) for increasing entry into intensive substance abuse treatment in veteran patients. Methods: Veteran patients (N = 84) with substance use disorders referred for an intake assessment in a substance abuse specialty clinic received either (i) intake assessment plus BMF or (ii) intake assessment as usual (AAU). BMF consisted of brief motivational enhancement feedback pertaining to estimates of alcohol and drug consumption, money spent on drugs and alcohol, and self-reported problems due to substance abuse. Primary outcome was entry in treatment groups in an intensive outpatient program for substance abuse. Results: Patients in BMF and AAU conditions did not significantly differ on indices of treatment entry. However, among patients with comorbid substance dependence and psychiatric disorders, those who received BMF were significantly more likely to enter outpatient treatment groups. Conclusions and Scientific Significance: The addition of motivational feedback to a standard intake assessment enhanced substance abuse treatment entry among veteran patients with comorbid substance use disorders and psychiatric disorders. These preliminary findings extend the use of motivational feedback to facilitate entry into substance abuse treatment among veteran patients with comorbid substance use and psychiatric disorders. Furthermore, they suggest opportunity for more effective patient-treatment matching based on initial motivation and other individual factors such as psychiatric comorbidity. Adapted from the source document. JF - The American Journal on Addictions AU - Lozano, Brian E AU - LaRowe, Steven D AU - Smith, Joshua P AU - Tuerk, Peter AU - Roitzsch, John AD - Mental Health Service 116, Ralph H. Johnson VAMC, 109 Bee Street, Charleston, SC 29401 brian.lozano@va.gov Y1 - 2013/03// PY - 2013 DA - March 2013 SP - 132 EP - 135 PB - Wiley Subscription Services, Inc. VL - 22 IS - 2 SN - 1055-0496, 1055-0496 KW - Veterans KW - Psychiatric disorders KW - Feedback KW - Treatment KW - Comorbidity KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1347817621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+on+Addictions&rft.atitle=Brief+Motivational+Feedback+May+Enhance+Treatment+Entry+in+Veterans+with+Comorbid+Substance+Use+and+Psychiatric+Disorders&rft.au=Lozano%2C+Brian+E%3BLaRowe%2C+Steven+D%3BSmith%2C+Joshua+P%3BTuerk%2C+Peter%3BRoitzsch%2C+John&rft.aulast=Lozano&rft.aufirst=Brian&rft.date=2013-03-01&rft.volume=22&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+on+Addictions&rft.issn=10550496&rft_id=info:doi/10.1111%2Fj.1521-0391.2013.00315.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Substance abuse; Comorbidity; Veterans; Feedback; Psychiatric disorders; Treatment DO - http://dx.doi.org/10.1111/j.1521-0391.2013.00315.x ER - TY - JOUR T1 - Management Support, Worksite Culture, and Local Resources for Healthier Employees: The Veterans Affairs Experience AN - 1323818900; 17841214 AB - Objective: To determine whether a "worksite culture of health" exists within the Veterans Health Administration and implications on integrating employee health promotion programs. Methods: Three national surveys were used--an organizational health survey, a health behaviors survey, and a worksite environment survey. Cross-sectional associations between measures of organizational health and employee health behaviors and between measures of organizational health and worksite environment were assessed. Results: There were significant associations between a number of organizational health measures and a combined measure of health behaviors. Likewise, presence of employee-wellness committees and/or coaches was significantly associated with higher appraisal on organizational health measures. Conclusion: Results suggest that a worksite culture of health exists in some but not all facilities within Veterans Health Administration; this has implications for integrating employee health promotion programs systemwide. A phased-in approach is likely warranted. JF - Journal of Occupational and Environmental Medicine AU - Schult, T M AU - Galway, A M AU - Awosika, E R AU - Schmunk, S K AU - Hodgson, M AD - Veterans Health Administration, One Veterans Drive, Bldg 68, Rm 138 (V68), Minneapolis, MN 55417, USA, tamara.schult@va.gov PY - 2013 SP - 310 EP - 317 VL - 55 IS - 3 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Committees KW - Working conditions KW - Health promotion KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1323818900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Management+Support%2C+Worksite+Culture%2C+and+Local+Resources+for+Healthier+Employees%3A+The+Veterans+Affairs+Experience&rft.au=Schult%2C+T+M%3BGalway%2C+A+M%3BAwosika%2C+E+R%3BSchmunk%2C+S+K%3BHodgson%2C+M&rft.aulast=Schult&rft.aufirst=T&rft.date=2013-03-01&rft.volume=55&rft.issue=3&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31827dba1e LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-04-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Committees; Working conditions; Health promotion DO - http://dx.doi.org/10.1097/JOM.0b013e31827dba1e ER - TY - JOUR T1 - The K1 Capsular Polysaccharide from Acinetobacter baumannii Is a Potential Therapeutic Target via Passive Immunization AN - 1315615079; 17720528 AB - The emergence of extremely resistant and panresistant Gram-negative bacilli, such as Acinetobacter baumannii, requires consideration of nonantimicrobial therapeutic approaches. The goal of this report was to evaluate the K1 capsular polysaccharide from A. baumannii as a passive immunization target. Its structure was determined by a combination of mass spectrometric and nuclear magnetic resonance (NMR) techniques. Molecular mimics that might raise the concern for autoimmune disease were not identified. Immunization of CD1 mice demonstrated that the K1 capsule is immunogenic. The monoclonal antibody (MAb) 13D6, which is directed against the K1 capsule from A. baumannii, was used to determine the seroprevalence of the K1 capsule in a collection of 100 A. baumannii strains. Thirteen percent of the A. baumannii isolates from this collection were seroreactive to MAb 13D6. Opsonization of K1-positive strains, but not K1-negative strains, with MAb 13D6 significantly increased neutrophil-mediated bactericidal activity in vitro (P < 0.05). Lastly, treatment with MAb 13D6 3 and 24 h after bacterial challenge in a rat soft tissue infection model resulted in a significant decrease in the growth/survival of a K1-positive strain compared to that of a K1-negative strain or to treatment with a vehicle control (P < 0.0001). These data support the proof of principle that the K1 capsule is a potential therapeutic target via passive immunization. Other serotypes require assessment, and pragmatic challenges exist, such as the need to serotype infecting strains and utilize serotype-specific therapy. Nonetheless, this approach may become an important therapeutic option with increasing antimicrobial resistance and a diminishing number of active antimicrobials. JF - Infection and Immunity AU - Russo, Thomas A AU - Beanan, Janet M AU - Olson, Ruth AU - MacDonald, Ulrike AU - Cox, Andrew D AU - Michael, Frank St AU - Vinogradov, Evgeny V AU - Spellberg, Brad AU - Luke-Marshall, Nicole R AU - Campagnari, Anthony A AD - Veterans Administration Western New York Healthcare System, ThomasA.Russo,trusso{at}acsu.buffalo.edu. Y1 - 2013/03// PY - 2013 DA - Mar 2013 SP - 915 EP - 922 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 81 IS - 3 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Data processing KW - Serotypes KW - Monoclonal antibodies KW - Drug resistance KW - Autoimmune diseases KW - Animal models KW - Infection KW - Antimicrobial agents KW - Acinetobacter baumannii KW - Immunogenicity KW - Gram-negative bacilli KW - N.M.R. KW - Immunization (passive) KW - Bactericidal activity KW - Soft tissues KW - Capsular polysaccharides KW - Opsonization KW - F 06910:Microorganisms & Parasites KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1315615079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=The+K1+Capsular+Polysaccharide+from+Acinetobacter+baumannii+Is+a+Potential+Therapeutic+Target+via+Passive+Immunization&rft.au=Russo%2C+Thomas+A%3BBeanan%2C+Janet+M%3BOlson%2C+Ruth%3BMacDonald%2C+Ulrike%3BCox%2C+Andrew+D%3BMichael%2C+Frank+St%3BVinogradov%2C+Evgeny+V%3BSpellberg%2C+Brad%3BLuke-Marshall%2C+Nicole+R%3BCampagnari%2C+Anthony+A&rft.aulast=Russo&rft.aufirst=Thomas&rft.date=2013-03-01&rft.volume=81&rft.issue=3&rft.spage=915&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01184-12 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-01 N1 - Number of references - 58 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Serotypes; Data processing; Monoclonal antibodies; Drug resistance; Autoimmune diseases; Animal models; Infection; Antimicrobial agents; Gram-negative bacilli; Immunogenicity; Immunization (passive); N.M.R.; Capsular polysaccharides; Soft tissues; Bactericidal activity; Opsonization; Acinetobacter baumannii DO - http://dx.doi.org/10.1128/IAI.01184-12 ER - TY - JOUR T1 - Treatment adherence in cognitive processing therapy for combat-related PTSD with history of mild TBI AN - 1438663647; 201320734 AB - Objective: This retrospective study examined treatment adherence in Cognitive Processing Therapy (CPT) for combat-related posttraumatic stress disorder (PTSD) in Veterans of Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) with and without history of mild traumatic brain injury (mTBI). Method: Medical record review of consecutive referrals to an outpatient PTSD clinic identified veterans diagnosed with combat-related PTSD who began treatment with CPT. The sample (N = 136) was grouped according to positive (n = 44) and negative (n = 92) mTBI history. Groups were compared in terms of presenting symptoms and treatment adherence. Results: The groups were not different on a pretreatment measure of depression, but self-reported and clinician-rated PTSD symptoms were higher in veterans with history of mTBI. The treatment completion rate was greater than 61% in both groups. The number of sessions attended averaged 9.6 for the PTSD group and 7.9 for the mTBI/PTSD group (p = .05). Implications: Given the lack of marked group differences in treatment adherence, these initial findings suggest that standard CPT for PTSD may be a tolerable treatment for OEF/OIF veterans with a history of PTSD and mTBI as well as veterans with PTSD alone. [Copyright The American Psychological Association.] JF - Rehabilitation Psychology AU - Davis, Jeremy J AU - Walter, Kristen H AU - Chard, Kathleen M AU - Parkinson, R Bruce AU - Houston, Wes S Y1 - 2013/02// PY - 2013 DA - February 2013 SP - 36 EP - 42 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 58 IS - 1 SN - 0090-5550, 0090-5550 KW - cognitive processing therapy KW - mild traumatic brain injury KW - posttraumatic stress disorder KW - veterans KW - treatment adherence KW - Veterans KW - Symptoms KW - Posttraumatic stress disorder KW - Adherence KW - Freedom KW - Cognitive processing KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438663647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rehabilitation+Psychology&rft.atitle=Treatment+adherence+in+cognitive+processing+therapy+for+combat-related+PTSD+with+history+of+mild+TBI&rft.au=Davis%2C+Jeremy+J%3BWalter%2C+Kristen+H%3BChard%2C+Kathleen+M%3BParkinson%2C+R+Bruce%3BHouston%2C+Wes+S&rft.aulast=Davis&rft.aufirst=Jeremy&rft.date=2013-02-01&rft.volume=58&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Rehabilitation+Psychology&rft.issn=00905550&rft_id=info:doi/10.1037%2Fa0031525 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Veterans; Adherence; Freedom; Symptoms; Cognitive processing DO - http://dx.doi.org/10.1037/a0031525 ER - TY - JOUR T1 - Mental disorder comorbidity and suicide among 2.96 million men receiving care in the veterans health administration health system AN - 1438662184; 201320680 AB - Comorbid mental disorders are common among suicide decedents. It is unclear if mental disorders in combination confer additive risk for suicide, in other words, if risk associated with two disorders is approximately the sum of the risk conferred by each disorder considered separately, or if there are departures from additivity such that the combined risk is less (i.e., subadditive) or more than additive (i.e., synergistic). Using a retrospective cohort design, all male Department of Veterans Affairs, Veterans Health Administration (VHA) service users who utilized VHA services in fiscal year (FY) 1999 and were alive at the start or FY 2000 (N = 2,962,810) were analyzed. Individuals were followed until death or the end of FY 2006. Using the VHA National Patient Care Database, diagnoses of mental disorders in FY 1999 were grouped into six categories (e.g., posttraumatic stress disorder). In proportional hazards models, 2-way interactions between disorders were used to examine departures from additive risk. There were 7,426 suicide deaths in the study period. Two-way interaction tests were nearly all statistically significant, indicating departures from additivity, and the results of these tests were consistent with subadditive risk. Sensitivity analyses examining the first year of follow-up showed similar results. Subadditive risk may be explained by factors that serve to lower the increased risk associated with a comorbid diagnosis, which may include common underlying causes of mental disorders, difficulties of differential diagnosis, the nature of etiological relationships between mental disorders, and intensive clinical care and monitoring of patients with comorbidity. [Copyright American Psychological Association] JF - Journal of Abnormal Psychology AU - Conner, Kenneth R AU - Bohnert, Amy S AU - McCarthy, John F AU - Valenstein, Marcia AU - Bossarte, Robert AU - Ignacio, Rosalinda AU - Lu, Naiji AU - Ilgen, Mark A Y1 - 2013/02// PY - 2013 DA - February 2013 SP - 256 EP - 263 PB - American Psychological Association, Washington DC VL - 122 IS - 1 SN - 0021-843X, 0021-843X KW - cohort KW - comorbidity KW - suicide KW - veterans KW - mental disorders KW - Psychiatric disorders KW - Suicide KW - Health KW - Additives KW - Comorbidity KW - Military hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438662184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Psychology&rft.atitle=Mental+disorder+comorbidity+and+suicide+among+2.96+million+men+receiving+care+in+the+veterans+health+administration+health+system&rft.au=Conner%2C+Kenneth+R%3BBohnert%2C+Amy+S%3BMcCarthy%2C+John+F%3BValenstein%2C+Marcia%3BBossarte%2C+Robert%3BIgnacio%2C+Rosalinda%3BLu%2C+Naiji%3BIlgen%2C+Mark+A&rft.aulast=Conner&rft.aufirst=Kenneth&rft.date=2013-02-01&rft.volume=122&rft.issue=1&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Psychology&rft.issn=0021843X&rft_id=info:doi/10.1037%2Fa0030163 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JABCAA N1 - SubjectsTermNotLitGenreText - Psychiatric disorders; Comorbidity; Suicide; Additives; Military hospitals; Health DO - http://dx.doi.org/10.1037/a0030163 ER - TY - JOUR T1 - Suicide Attempts and Suicide among Marines: A Decade of Follow-up AN - 1347782407; 201321592 AB - Suicidal behavior among military personnel is of paramount public health importance because of the increased risk of death from suicide in this population. Pre- and post-Marine recruit training risk factors for suicide attempts among current and former Marines were examined in 10 years following recruit training. The characteristics of the subsample of current and former Marines who died by suicide during this time are also described. Stressful and traumatic life events (e.g., childhood physical, sexual, and emotional abuse, sexual harassment during recruit training) and pre-recruit training suicide attempts emerged as having strong associations with post-recruit training attempts. Half of those who died by suicide in the 10 years following recruit training endorsed at least one significant life stressor prior to joining the Marines. This study highlights the importance of screening for stressful and potentially traumatic experiences occurring both before and during military service as part of a comprehensive suicide risk assessment in military samples. Adapted from the source document. JF - Suicide and Life-Threatening Behavior AU - Gradus, Jaimie L AU - Shipherd, Jillian C AU - Suvak, Michael K AU - Giasson, Hannah L AU - Miller, Matthew AD - VA Boston Healthcare System, National Center for PTSD, 150 S. Huntington Ave, 116B-3, Boston, MA 02130 jaimie.gradus@va.gov Y1 - 2013/02// PY - 2013 DA - February 2013 SP - 39 EP - 49 PB - John Wiley & Sons, Inc. VL - 43 IS - 1 SN - 0363-0234, 0363-0234 KW - Emotional Abuse KW - Public Health KW - Training KW - Military Personnel KW - Sexual Harassment KW - Military Service KW - Suicide KW - Risk Assessment KW - Trauma KW - article KW - 1978: the family and socialization; sociology of death & dying UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1347782407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Suicide+and+Life-Threatening+Behavior&rft.atitle=Suicide+Attempts+and+Suicide+among+Marines%3A+A+Decade+of+Follow-up&rft.au=Gradus%2C+Jaimie+L%3BShipherd%2C+Jillian+C%3BSuvak%2C+Michael+K%3BGiasson%2C+Hannah+L%3BMiller%2C+Matthew&rft.aulast=Gradus&rft.aufirst=Jaimie&rft.date=2013-02-01&rft.volume=43&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Suicide+and+Life-Threatening+Behavior&rft.issn=03630234&rft_id=info:doi/10.1111%2Fj.1943-278X.2012.00126.x LA - English DB - Sociological Abstracts N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SLBEDP N1 - SubjectsTermNotLitGenreText - Suicide; Training; Trauma; Military Service; Risk Assessment; Public Health; Emotional Abuse; Military Personnel; Sexual Harassment DO - http://dx.doi.org/10.1111/j.1943-278X.2012.00126.x ER - TY - JOUR T1 - Suicidal ideation and social exchanges among at-risk veterans referred for a behavioral health assessment AN - 1323810695; 17671676 AB - Purpose: The current study examined the independent association between positive (e.g., emotional and instrumental support) and negative (e.g., insensitive behavior, unwanted advice from others) social exchanges and suicidal ideation among veterans referred for a behavioral health assessment. Methods: The sample included 606 veterans [mean age = 54.96 (SD = 14.96)] referred by primary care for a clinical mental health/substance abuse (MH/SA) assessment following a positive MH/SA screen. Data on sociodemographics, MH/SA conditions (e.g., depression, PTSD, anxiety, and alcohol abuse), the self-reported frequency of positive and negative social exchanges, and suicidal ideation were extracted from clinical interviews and evaluated. Results: Veterans were primarily male, non-married, and had adequate financial resources, and approximately half were White. 74.4 and 20.3 % met criteria for a MH/SA condition and suicidal ideation, respectively. Multiple logistic regression analyses revealed that, adjusting for sociodemographics, physical functioning, and comorbid MH/SA conditions, veterans reporting more frequent negative exchanges with network members were significantly more likely to report suicidal ideation. Positive exchanges, in contrast, were not significantly related to the outcome. Inadequate finances and MH/SA conditions also were significantly related to suicidal ideation. Conclusions: Findings highlight the value of exploring the quality of social exchanges among veterans in primary care who screen positive for behavioral health issues, as such information has the potential to inform screening and intervention efforts aimed at reducing suicidal ideation. JF - Social Psychiatry and Psychiatric Epidemiology AU - Mavandadi, Shahrzad AU - Rook, Karen S AU - Newsom, Jason T AU - Oslin, David W AD - Mental Illness Research, Education and Clinical Center, Philadelphia VA Medical Center, 3900 Woodland Ave, B215, Philadelphia, PA, 19104, USA, Shahrzad.Mavandadi@va.gov Y1 - 2013/02// PY - 2013 DA - Feb 2013 SP - 233 EP - 243 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 48 IS - 2 SN - 0933-7954, 0933-7954 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Alcohol KW - Mental disorders KW - Age KW - Depression KW - Posttraumatic stress disorder KW - Suicide KW - Intervention KW - Substance abuse KW - H 4000:Food and Drugs KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1323810695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Psychiatry+and+Psychiatric+Epidemiology&rft.atitle=Suicidal+ideation+and+social+exchanges+among+at-risk+veterans+referred+for+a+behavioral+health+assessment&rft.au=Mavandadi%2C+Shahrzad%3BRook%2C+Karen+S%3BNewsom%2C+Jason+T%3BOslin%2C+David+W&rft.aulast=Mavandadi&rft.aufirst=Shahrzad&rft.date=2013-02-01&rft.volume=48&rft.issue=2&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Social+Psychiatry+and+Psychiatric+Epidemiology&rft.issn=09337954&rft_id=info:doi/10.1007%2Fs00127-012-0534-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-04-01 N1 - Number of references - 58 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Alcohol; Age; Mental disorders; Posttraumatic stress disorder; Depression; Intervention; Suicide; Substance abuse DO - http://dx.doi.org/10.1007/s00127-012-0534-5 ER - TY - JOUR T1 - Cost Savings from Assertive Community Treatment Services in an Era of Declining Psychiatric Inpatient Use AN - 1323339565; 201305032 AB - To assess, during a period of decreasing psychiatric inpatient utilization, cost savings from Assertive Community Treatment (ACT) programs for individuals with severe mental illnesses. U.S. Department of Veterans Affairs' (VA) national administrative data for entrants into ACT programs. An observational study of the effects of ACT enrollment on mental health inpatient utilization and costs in the first 12 months following enrollment. ACT enrollees (N = 2010) were propensity score matched to ACT-eligible non-enrollees (N = 4020). An instrumental variables generalized linear regression approach was used to estimate enrollment effects. Instrumental variables estimates indicate that between FY2001 and FY2004, entry into ACT resulted in a net increase of $4529 in VA costs. Trends in inpatient use among ACT program entrants suggest this effect remained stable after FY2004. However, eligibility for ACT declined 37 percent, because fewer patients met an eligibility standard based on high prior psychiatric inpatient use. Savings from ACT programs depend on new enrollees' intensity of psychiatric inpatient utilization prior to entering the ACT program. Although a program eligibility standard based on prior psychiatric inpatient use helped to sustain the savings from VA ACT programs, over time, it also resulted in an unintended narrowing of program eligibility. Adapted from the source document. JF - Health Services Research AU - Slade, Eric P AU - McCarthy, John F AU - Valenstein, Marcia AU - Visnic, Stephanie AU - Dixon, Lisa B AD - Capitol Healthcare, Network (VISN 5) Mental Illness Research, Education, and Clinical Center. U.S. Department of Veterans Affairs Y1 - 2013/02// PY - 2013 DA - February 2013 SP - 195 EP - 217 PB - Blackwell Publishers, Oxford UK VL - 48 IS - 1 SN - 0017-9124, 0017-9124 KW - Mentally ill people KW - Savings KW - Psychiatric hospitals KW - Enrollment KW - Assertive community treatment KW - Eligibility KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1323339565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Cost+Savings+from+Assertive+Community+Treatment+Services+in+an+Era+of+Declining+Psychiatric+Inpatient+Use&rft.au=Slade%2C+Eric+P%3BMcCarthy%2C+John+F%3BValenstein%2C+Marcia%3BVisnic%2C+Stephanie%3BDixon%2C+Lisa+B&rft.aulast=Slade&rft.aufirst=Eric&rft.date=2013-02-01&rft.volume=48&rft.issue=1&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2012.01420.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Psychiatric hospitals; Eligibility; Enrollment; Assertive community treatment; Savings; Mentally ill people DO - http://dx.doi.org/10.1111/j.1475-6773.2012.01420.x ER - TY - JOUR T1 - Correlates of prescription opioid initiation and long-term opioid use in veterans with persistent pain. AN - 1285081155; 23269280 AB - Little is known about how opioid prescriptions for chronic pain are initiated. We sought to describe patterns of prescription opioid initiation, identify correlates of opioid initiation, and examine correlates of receipt of chronic opioid therapy (COT) among veterans with persistent noncancer pain. Using Veterans Affairs administrative data, we identified 5961 veterans from the Pacific Northwest with persistent elevated pain intensity scores who had not been prescribed opioids in the prior 12 months. We compared veterans not prescribed opioids over the subsequent 12 months with those prescribed any opioid and to those prescribed COT (>90 consecutive days). During the study year, 35% of the sample received an opioid prescription and 5% received COT. Most first opioid prescriptions were written by primary care clinicians. Veterans prescribed COT were younger, had greater pain intensity, and high rates of psychiatric and substance use disorders compared with veterans in the other 2 groups. Among patients receiving COT, 29% were prescribed long-acting opioids, 37% received 1 or more urine drug screens, and 24% were prescribed benzodiazepines. Adjusting for age, sex, and baseline pain intensity, major depression [odds ratio 1.24 (1.10-1.39); 1.48 (1.14-1.93)], and nicotine dependence [1.34 (1.17-1.53); 2.02 (1.53-2.67)] were associated with receiving any opioid prescription and with COT, respectively. Opioid initiations are common among veterans with persistent pain, but most veterans are not prescribed opioids long-term. Psychiatric disorders and substance use disorders are associated with receiving COT. Many Veterans receiving COT are concurrently prescribed benzodiazepines and many do not receive urine drug screening; additional study regarding practices that optimize safety of COT in this population is indicated. JF - The Clinical journal of pain AU - Dobscha, Steven K AU - Morasco, Benjamin J AU - Duckart, Jonathan P AU - Macey, Tara AU - Deyo, Richard A AD - Mental Health and Clinical Neurosciences Division, Portland VA Medical Center, OR 97239, USA. steven.dobscha@va.gov Y1 - 2013/02// PY - 2013 DA - February 2013 SP - 102 EP - 108 VL - 29 IS - 2 KW - Analgesics, Opioid KW - 0 KW - Prescription Drugs KW - Index Medicus KW - United States KW - Prescription Drug Misuse KW - Practice Patterns, Physicians' KW - Humans KW - Retrospective Studies KW - Aged KW - Pain Measurement KW - Primary Health Care KW - Longitudinal Studies KW - Opioid-Related Disorders -- etiology KW - Veterans KW - United States Department of Veterans Affairs KW - Mental Disorders -- drug therapy KW - Adult KW - Middle Aged KW - Time Factors KW - Analgesics, Opioid -- therapeutic use KW - Chronic Pain -- drug therapy KW - Statistics as Topic KW - Analgesics, Opioid -- adverse effects KW - Prescription Drugs -- therapeutic use KW - Chronic Pain -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1285081155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Clinical+journal+of+pain&rft.atitle=Correlates+of+prescription+opioid+initiation+and+long-term+opioid+use+in+veterans+with+persistent+pain.&rft.au=Dobscha%2C+Steven+K%3BMorasco%2C+Benjamin+J%3BDuckart%2C+Jonathan+P%3BMacey%2C+Tara%3BDeyo%2C+Richard+A&rft.aulast=Dobscha&rft.aufirst=Steven&rft.date=2013-02-01&rft.volume=29&rft.issue=2&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=The+Clinical+journal+of+pain&rft.issn=1536-5409&rft_id=info:doi/10.1097%2FAJP.0b013e3182490bdb LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-06-05 N1 - Date created - 2012-12-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pain. 2010 Jan;11(1):44-52 [19628436] J Opioid Manag. 2010 Mar-Apr;6(2):133-9 [20481178] Anesthesiology. 2010 Oct;113(4):977-92 [20864835] Pain. 2011 Mar;152(3):488-97 [21185119] J Pain. 2011 Mar;12(3):352-9 [20851057] Arch Intern Med. 2011 Apr 11;171(7):686-91 [21482846] Pain Med. 2011 May;12(5):740-6 [21481167] Pain. 2011 Jun;152(6):1256-62 [21296498] J Gen Intern Med. 2011 Sep;26(9):958-64 [21347877] J Gen Intern Med. 2011 Sep;26(9):965-71 [21562923] Pain Med. 2011 Oct;12(10):1502-9 [21899715] Clin J Pain. 1997 Dec;13(4):330-6 [9430814] J Pain Symptom Manage. 2002 Feb;23(2):131-7 [11844633] Clin J Pain. 2002 Nov-Dec;18(6):355-65 [12441829] Clin J Pain. 2003 Sep-Oct;19(5):298-305 [12966255] J Pain Symptom Manage. 2003 Nov;26(5):1026-48 [14585554] J Pain. 2003 Aug;4(6):344-50 [14622692] J Rehabil Res Dev. 2003 Sep-Oct;40(5):371-9 [15080222] J Pain Symptom Manage. 2004 Aug;28(2):176-88 [15276196] Pain Suppl. 1986;3:S1-226 [3461421] Pain. 1986 Oct;27(1):117-26 [3785962] J Chronic Dis. 1987;40(5):373-83 [3558716] Arch Intern Med. 1998 Mar 23;158(6):626-32 [9521227] Ann Intern Med. 2010 Jan 19;152(2):85-92 [20083827] Clin J Pain. 2010 Jan;26(1):1-8 [20026946] Pain. 2004 Dec;112(3):372-80 [15561393] NCHS Data Brief. 2009 Sep;(22):1-8 [19796521] Pol Arch Med Wewn. 2009 Jul-Aug;119(7-8):469-77 [19776687] J Pain. 2009 Feb;10(2):113-30 [19187889] J Pain Symptom Manage. 2008 Sep;36(3):280-8 [18619768] Clin J Pain. 2008 Jul-Aug;24(6):521-7 [18574361] Pain Med. 2007 Nov-Dec;8(8):647-56 [18028043] Pain. 2007 Jun;129(3):355-62 [17449178] Pain. 2007 Jun;129(3):332-42 [17350169] Ann Intern Med. 2007 Jan 16;146(2):116-27 [17227935] Arch Intern Med. 2006 Oct 23;166(19):2087-93 [17060538] Pain. 2005 Dec 15;119(1-3):95-103 [16298066] Pharmacoepidemiol Drug Saf. 2009 Dec;18(12):1166-75 [19718704] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/AJP.0b013e3182490bdb ER - TY - JOUR T1 - Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish. AN - 1284625512; 23274813 AB - Altered dopaminergic signaling causes behavioral changes in mammals. In general, dopaminergic receptor agonists increase locomotor activity, while antagonists decrease locomotor activity. In order to determine if zebrafish (a model organism becoming popular in pharmacology and toxicology) respond similarly, the acute effects of drugs known to target dopaminergic receptors in mammals were assessed in zebrafish larvae. Larvae were maintained in 96-well microtiter plates (1 larva/well). Non-lethal concentrations (0.2-50 μM) of dopaminergic agonists (apomorphine, SKF-38393, and quinpirole) and antagonists (butaclamol, SCH-23390, and haloperidol) were administered at 6 days post-fertilization (dpf). An initial experiment identified the time of peak effect of each drug (20-260 min post-dosing, depending on the drug). Locomotor activity was then assessed for 70 min in alternating light and dark at the time of peak effect for each drug to delineate dose-dependent effects. All drugs altered larval locomotion in a dose-dependent manner. Both the D1- and D2-like selective agonists (SKF-38393 and quinpirole, respectively) increased activity, while the selective antagonists (SCH-23390 and haloperidol, respectively) decreased activity. Both selective antagonists also blunted the response of the larvae to changes in lighting conditions at higher doses. The nonselective drugs had biphasic effects on locomotor activity: apomorphine increased activity at the low dose and at high doses, while butaclamol increased activity at low to intermediate doses, and decreased activity at high doses. This study demonstrates that (1) larval zebrafish locomotion can be altered by dopamine receptor agonists and antagonists, (2) receptor agonists and antagonists generally have opposite effects, and (3) drugs that target dopaminergic receptors in mammals appear, in general, to elicit similar locomotor responses in zebrafish larvae. Published by Elsevier Inc. JF - Pharmacology, biochemistry, and behavior AU - Irons, T D AU - Kelly, P E AU - Hunter, D L AU - Macphail, R C AU - Padilla, S AD - Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Terra.Irons@va.gov Y1 - 2013/02// PY - 2013 DA - February 2013 SP - 792 EP - 813 VL - 103 IS - 4 KW - Dopamine Agents KW - 0 KW - Dopamine Agonists KW - Dopamine Antagonists KW - Receptors, Dopamine KW - Index Medicus KW - Models, Animal KW - Animals KW - Receptors, Dopamine -- physiology KW - Larva -- physiology KW - Dose-Response Relationship, Drug KW - Dopamine Agonists -- administration & dosage KW - Larva -- drug effects KW - Dopamine Antagonists -- administration & dosage KW - Motor Activity -- physiology KW - Motor Activity -- drug effects KW - Zebrafish -- physiology KW - Dopamine Agents -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1284625512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Acute+administration+of+dopaminergic+drugs+has+differential+effects+on+locomotion+in+larval+zebrafish.&rft.au=Irons%2C+T+D%3BKelly%2C+P+E%3BHunter%2C+D+L%3BMacphail%2C+R+C%3BPadilla%2C+S&rft.aulast=Irons&rft.aufirst=T&rft.date=2013-02-01&rft.volume=103&rft.issue=4&rft.spage=792&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=1873-5177&rft_id=info:doi/10.1016%2Fj.pbb.2012.12.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-10-24 N1 - Date created - 2013-02-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell Mol Neurobiol. 1991 Oct;11(5):437-53 [1835903] Pol J Pharmacol Pharm. 1991 Nov-Dec;43(6):507-28 [1687945] Ann Neurol. 1992;32 Suppl:S88-93 [1510386] J Neurochem. 1992 Oct;59(4):1499-505 [1402901] J Neurosci. 1992 Dec;12(12):4911-22 [1281499] Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12093-7 [1334557] J Comp Neurol. 1993 May 22;331(4):469-81 [8509505] Brain Res. 1993 Jun 18;614(1-2):57-64 [8348331] Pharmacol Biochem Behav. 1994 Jul;48(3):781-6 [7938135] Psychopharmacology (Berl). 1994 Oct;116(2):217-25 [7862951] Br J Psychiatry. 1995 Oct;167(4):480-2 [8829716] Dev Dyn. 1995 Jul;203(3):253-310 [8589427] Neuropsychopharmacology. 1996 Feb;14(2):87-96 [8822531] Eur J Neurosci. 1996 Nov;8(11):2286-97 [8950093] Vis Neurosci. 1997 May-Jun;14(3):545-51 [9194321] Psychopharmacology (Berl). 1997 Oct;133(3):233-9 [9361328] Physiol Rev. 1998 Jan;78(1):189-225 [9457173] Cell Mol Neurobiol. 1999 Oct;19(5):653-64 [10384262] Mol Neurobiol. 1999 Jun;19(3):181-204 [10495103] Exp Neurol. 2005 Feb;191 Suppl 1:S104-12 [15629757] Schizophr Res. 2005 Jun 1;75(1):65-75 [15820325] Vet Pathol. 2005 Nov;42(6):753-73 [16301571] Neurotoxicol Teratol. 2006 Mar-Apr;28(2):245-50 [16527449] Genes Brain Behav. 2007 Mar;6(2):155-66 [16764679] Dev Dyn. 2007 May;236(5):1339-46 [17393486] Trends Neurosci. 2007 May;30(5):188-93 [17368565] J Exp Biol. 2007 Jul;210(Pt 14):2526-39 [17601957] J Exp Zool B Mol Dev Evol. 2007 Sep 15;308(5):550-62 [17024661] J Neurosci. 2007 Nov 28;27(48):13192-204 [18045913] J Neural Transm (Vienna). 2008 May;115(5):677-81 [18188494] J Vis Exp. 2008;(20). pii: 923. doi: 10.3791/923 [19078942] Vision Res. 2009 May;49(9):943-59 [18722397] Adv Exp Med Biol. 2009;651:1-14 [19731546] Behav Neurosci. 2009 Dec;123(6):1279-87 [20001111] Science. 2010 Jan 15;327(5963):348-51 [20075256] Behav Brain Res. 2010 Mar 5;207(2):223-31 [19836422] Neurotoxicol Teratol. 2010 Jan-Feb;32(1):84-90 [19465114] Neuroscience. 2010 Mar 17;166(2):391-6 [20026251] Neurotoxicology. 2009 Jan;30(1):52-8 [18952124] J Neurosci. 2010 Apr 28;30(17):6048-57 [20427663] Behav Pharmacol. 2010 May;21(3):171-81 [20463460] Brain Res. 2010 Aug 19;1349:41-7 [20558148] BMC Neurosci. 2010;11:90 [20678210] Zebrafish. 2010 Dec;7(4):359-78 [21158565] Pak J Pharm Sci. 2011 Jan;24(1):7-12 [21190911] J Neurosci. 2011 Apr 6;31(14):5512-25 [21471388] Behav Brain Res. 2011 Oct 10;224(1):135-9 [21669233] Neurobiol Dis. 2011 Oct;44(1):9-18 [21669287] Prog Neuropsychopharmacol Biol Psychiatry. 2012 Mar 30;36(2):258-63 [22019856] Dev Neurobiol. 2012 Mar;72(3):256-68 [21567980] Curr Biol. 2012 Nov 6;22(21):2042-7 [23000151] Brain Res. 2001 Jan 19;889(1-2):316-30 [11166725] J Neurosci. 2001 Jun 15;21(12):4390-9 [11404425] J Neurosci. 2000 Aug 15;20(16):RC91 [10924528] Brain Res Dev Brain Res. 2002 Jul 30;137(1):89-100 [12128258] J Pharmacol Exp Ther. 2002 Nov;303(2):791-804 [12388666] Prog Neurobiol. 2002 Oct;68(2):85-111 [12450489] Neurotoxicol Teratol. 2003 May-Jun;25(3):311-28 [12757828] Neurotox Res. 2003;5(1-2):95-110 [12832225] Genes Brain Behav. 2003 Oct;2(5):268-81 [14606692] Arch Neurol. 2004 May;61(5):641-4 [15148138] Dev Dyn. 2004 Jul;230(3):481-93 [15188433] J Neurophysiol. 1969 May;32(3):424-42 [4308417] Psychopharmacologia. 1975 Apr 30;42(1):11-20 [1171496] Pharmacol Ther B. 1976;2(1):37-40 [772721] Eur J Pharmacol. 1979 Dec 7;60(2-3):163-70 [575095] Exp Neurol. 1981 Feb;71(2):326-40 [6256200] Eur J Pharmacol. 1983 Jul 15;91(1):153-4 [6225651] Psychopharmacology (Berl). 1983;81(2):126-34 [6138794] Vision Res. 1983;23(11):1293-8 [6659376] Science. 1985 Apr 12;228(4696):143-9 [3975635] Pharmacol Biochem Behav. 1985 Oct;23(4):555-7 [4070332] Eur J Pharmacol. 1986 Nov 19;131(2-3):301-6 [3493161] Eur J Pharmacol. 1988 Feb 9;146(2-3):319-26 [2836210] Brain Res. 1988 May 24;449(1-2):332-6 [3293703] Psychopharmacology (Berl). 1989;98(2):245-50 [2569218] Neurotoxicol Teratol. 1989 Sep-Oct;11(5):421-5 [2593980] Nature. 1990 Sep 13;347(6289):146-51 [1975644] Brain Res. 1990 Nov 12;533(1):20-3 [2150768] J Pharmacol Exp Ther. 1991 Sep;258(3):910-7 [1890625] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.pbb.2012.12.010 ER - TY - JOUR T1 - Instituting systems-based practice and practice-based learning and improvement: a curriculum of inquiry AN - 1558997453; 201432627 AB - Background: The Accreditation Council for Graduate Medical Education (ACGME) requires that training programs integrate system-based practice (SBP) and practice-based learning and improvement (PBLI) into internal medicine residency curricula. Context and setting: We instituted a seminar series and year-long-mentored curriculum designed to engage internal medicine residents in these competencies. Methods: Residents participate in a seminar series that includes assigned reading and structured discussion with faculty who assist in the development of quality improvement or research projects. Residents pursue projects over the remainder of the year. Monthly works in progress meetings, protected time for inquiry, and continued faculty mentorship guide the residents in their project development. Trainees present their work at hospital-wide grand rounds at the end of the academic year. We performed a survey of residents to assess their self-reported knowledge, attitudes and skills in SBP and PBLI. In addition, blinded faculty scored projects for appropriateness, impact, and feasibility. Outcomes: We measured resident self-reported knowledge, attitudes, and skills at the end of the academic year. We found evidence that participants improved their understanding of the context in which they were practicing, and that their ability to engage in quality improvement projects increased. Blinded faculty reviewers favorably ranked the projects' feasibility, impact, and appropriateness. The 'Curriculum of Inquiry' generated 11 quality improvement and research projects during the study period. Barriers to the ongoing work include a limited supply of mentors and delays due to Institutional Review Board approval. Hospital leadership recognizes the importance of the curriculum, and our accreditation manager now cites our ongoing work. Conclusions: A structured residency-based curriculum facilitates resident demonstration of SBP and practice-based learning and improvement. Residents gain knowledge and skills though this enterprise and hospitals gain access to trainees who help to solve ongoing problems and meet accreditation requirements. Adapted from the source document. JF - Medical Education Online AU - Wilper, Andrew P AU - Smith, Curtis Scott AU - Weppner, William AD - 500 West Fort Street Boise, ID 83702 USA; Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, USA; Boise VA Medical Center, Boise, ID, USA Andrew.wilper@va.gov Y1 - 2013///0, PY - 2013 DA - 0, 2013 SP - 1 EP - 6 PB - Co-Action Publishing, Sweden VL - 18 SN - 1087-2981, 1087-2981 KW - graduate medical education competencies longitudinal curriculum KW - Practice based education KW - Seminars KW - Curriculum KW - Professors KW - Quality management KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558997453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Education+Online&rft.atitle=Instituting+systems-based+practice+and+practice-based+learning+and+improvement%3A+a+curriculum+of+inquiry&rft.au=Wilper%2C+Andrew+P%3BSmith%2C+Curtis+Scott%3BWeppner%2C+William&rft.aulast=Wilper&rft.aufirst=Andrew&rft.date=2013-01-01&rft.volume=18&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Medical+Education+Online&rft.issn=10872981&rft_id=info:doi/10.3402%2Fmeo.v18i0.21612 L2 - http://med-ed-online.net/index.php/meo LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Curriculum; Professors; Quality management; Practice based education; Hospitals; Seminars DO - http://dx.doi.org/10.3402/meo.v18i0.21612 ER - TY - JOUR T1 - Telephone care coordination for smokers in VA mental health clinics: protocol for a hybrid type-2 effectiveness-implementation trial AN - 1558988045; 201431501 AB - This paper describes an innovative protocol for a type-II hybrid effectiveness-implementation trial that is evaluating a smoking cessation telephone care coordination program for Veterans Health Administration (VA) mental-health clinic patients. As a hybrid trial, the protocol combines implementation science and clinical trial methods and outcomes that can inform future cessation studies and the implementation of tobacco cessation programs into routine care. One of the primary objectives of the trial is to evaluate the process of adapting, implementing, and sustaining a smoking cessation telephone care coordination program in VA mental health clinics. This paper describes the rationale and methods of a trial designed to simultaneously study the clinical effectiveness and implementation of a telephone smoking cessation program for smokers using VA mental health clinics. Such hybrid designs are an important methodological design that can shorten the time between the development of an intervention and its translation into routine clinical care. Adapted from the source document. JF - NIDA Addiction Science & Clinical Practice AU - Rogers, Erin AU - Fernandez, Senaida AU - Gillespie, Colleen AU - Smelson, David AU - Hagedorn, Hildi J AU - Elbel, Brian AU - Kalman, David AU - Axtmayer, Alfredo AU - Kurowski, Karishma AU - Sherman, Scott E AD - VA New York Harbor Healthcare System, 423 East 23rd Street -- 15N, New York, NY 10010, USA; Department of Medicine, Division of General Internal Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA erin.rogers2@va.gov Y1 - 2013///0, PY - 2013 DA - 0, 2013 SP - 1 EP - 12 PB - RTI International, Rockville, MD VL - 8 SN - 1940-0632, 1940-0632 KW - Tobacco Smoking Mental health Intervention Implementation Psychiatry KW - Telephones KW - Smoking KW - Coordination KW - Cessation KW - Mental health KW - Clinics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558988045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+Addiction+Science+%26+Clinical+Practice&rft.atitle=Telephone+care+coordination+for+smokers+in+VA+mental+health+clinics%3A+protocol+for+a+hybrid+type-2+effectiveness-implementation+trial&rft.au=Rogers%2C+Erin%3BFernandez%2C+Senaida%3BGillespie%2C+Colleen%3BSmelson%2C+David%3BHagedorn%2C+Hildi+J%3BElbel%2C+Brian%3BKalman%2C+David%3BAxtmayer%2C+Alfredo%3BKurowski%2C+Karishma%3BSherman%2C+Scott+E&rft.aulast=Rogers&rft.aufirst=Erin&rft.date=2013-01-01&rft.volume=8&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NIDA+Addiction+Science+%26+Clinical+Practice&rft.issn=19400632&rft_id=info:doi/10.1186%2F1940-0640-8-7 L2 - http://www.drugabuse.gov/ascp/index.html LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Smoking; Cessation; Clinics; Telephones; Mental health; Coordination DO - http://dx.doi.org/10.1186/1940-0640-8-7 ER - TY - JOUR T1 - Screening for post-traumatic stress disorder (PTSD) in primary care: a systematic review AN - 1532454759; 42232 AB - Recently, the Institute of Medicine (IOM) released a report examining the screening, diagnosis, treatment, and rehabilitation services for military Veterans and service members with PTSD in the Department of Veterans Affairs and the Department of Defense.3 As noted in the IOM report and elsewhere, successful screening programs utilize instruments that are simple, valid, precise, and acceptable both clinically and socially.3-5 To identify screening tools that are best suited to the primary care setting, this evidence synthesis report reviews the literature on the feasibility and diagnostic accuracy of screening tools used and evaluated with a gold standard in a primary care setting. We addressed the following key questions: Key Question #1. What tools are used to screen for PTSD in primary care settings, and what are their characteristics (i.e., length, format/administration, response scale)? Key Question #2. What are the psychometric properties and utility of the screening tools (sensitivity, speciicity, likelihood ratios, predictive values, area under curve, reliability)? Key Question #3. What information is there about the implementability (e.g., ease of administration, patient satisfaction) of PTSD screening tools in primary care clinics? Key Question #4. Do the psychometric properties and utility of each of the screening tools differ according to age, gender, race/ethnicity, substance abuse, or other comorbidities? [Adapted from Text] AU - United States Department of Veterans Affairs Evidence-Based Synthesis Program (ESP) Center AU - Spoont, Michele R AU - Arbisi, Paul A AU - Fu, Steven S AU - Greer, Nancy AU - Kehle-Forbes, Shannon M AU - Meis, Laura A AU - Rutks, Indulis PY - 2013 SP - 2 EP - iii, 63 KW - Assessment Instruments KW - PTSD Assessment Instruments KW - Primary Health Care KW - PTSD KW - Systematic Review UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1532454759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apilots&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Screening+for+post-traumatic+stress+disorder+%28PTSD%29+in+primary+care%3A+a+systematic+review&rft.au=United+States+Department+of+Veterans+Affairs+Evidence-Based+Synthesis+Program+%28ESP%29+Center%3BSpoont%2C+Michele+R%3BArbisi%2C+Paul+A%3BFu%2C+Steven+S%3BGreer%2C+Nancy%3BKehle-Forbes%2C+Shannon+M%3BMeis%2C+Laura+A%3BRutks%2C+Indulis&rft.aulast=United+States+Department+of+Veterans+Affairs+Evidence-Based+Synthesis+Program+%28ESP%29+Center&rft.aufirst=&rft.date=2013-01-01&rft.volume=&rft.issue=&rft.spage=iii&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - PILOTS: Published International Literature On Traumatic Stress N1 - Date revised - 2016-09-15 N1 - SuppNotes - VA-ESP Project #09-009; 2013.; Systematic Review: 15 studies. N1 - Last updated - 2016-09-15 ER - TY - JOUR T1 - Nocturnal Blood Pressure Non-Dipping, Posttraumatic Stress Disorder, and Sleep Quality in Women AN - 1520311036; 201412806 AB - Women with posttraumatic stress disorder (PTSD) have poor sleep quality and increased risk of cardiovascular disease (CVD). Non-dipping of nocturnal blood pressure may be an explanatory factor for the relationship between sleep and CVD found in previous research. The current study was designed to determine if non-dipping nocturnal blood pressure was associated with trauma exposure. PTSD diagnosis, PTSD symptoms, and sleep quality in a sample of women. Participants completed 24 hours of ABPM and self-report questionnaires. Non-dipping was defined as less than 10% reduction in blood pressure during sleep. The frequency of nondippers did not differ by diagnostic status (d = .15). However, non-dippers endorsed more traumatic event categories (d = .53), more PTSD hyperarousal symptoms (d = .53), poorer overall sleep quality (d = .59), more frequent use of sleep medication (d = .62), greater sleep-related daytime dysfunction (d = .58), and longer sleep onset latencies (d = .55) than dippers. Increased attention to nocturnal blood pressure variation may be needed to improve blood pressure control in trauma-exposed women. Adapted from the source document. JF - Behavioral Medicine AU - Ulmer, Christi S AU - Calhoun, Patrick S AU - Bosworth, Hayden B AU - Dennis, Michelle F AU - Beckham, Jean C AD - Duke University Medical Center; HSR&D (152), Durham VAMC, 508 Fulton Street, Durham, NC 27705 christi.ulmer@va.gov Y1 - 2013///0, PY - 2013 DA - 0, 2013 SP - 111 EP - 121 PB - Taylor & Francis, Philadelphia PA VL - 39 IS - 1-4 SN - 0896-4289, 0896-4289 KW - cardiovascular disease circadian blood pressure psychological trauma PTSD sleep quality KW - Posttraumatic stress disorder KW - Sleep KW - Sleep problems KW - Women KW - Cardiovascular diseases KW - Blood pressure KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520311036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Medicine&rft.atitle=Nocturnal+Blood+Pressure+Non-Dipping%2C+Posttraumatic+Stress+Disorder%2C+and+Sleep+Quality+in+Women&rft.au=Ulmer%2C+Christi+S%3BCalhoun%2C+Patrick+S%3BBosworth%2C+Hayden+B%3BDennis%2C+Michelle+F%3BBeckham%2C+Jean+C&rft.aulast=Ulmer&rft.aufirst=Christi&rft.date=2013-01-01&rft.volume=39&rft.issue=1-4&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Behavioral+Medicine&rft.issn=08964289&rft_id=info:doi/10.1080%2F08964289.2013.813434 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BEMEEF N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Blood pressure; Women; Sleep problems; Cardiovascular diseases; Sleep DO - http://dx.doi.org/10.1080/08964289.2013.813434 ER - TY - JOUR T1 - Predictors of 1-, 6- and 12-month smoking cessation among a community-recruited sample of adult smokers in the United States AN - 1449098839; 201323636 AB - Baseline socio-demographics, substance use and smoking history characteristics, as well as intra-treatment indicators (i.e. nicotine patch adherence and tobacco use during patch treatment) of smoking cessation were examined among 65 community-based adult male smokers recruited from a metropolitan area within the United States. All participants were recruited between 2009 and 2010 and were enrolled in an 8-week smoking cessation programme involving nicotine patch treatment and adjunctive counselling. Stepwise multiple regression analyses were performed to examine unique predictors of smoking status at 1-, 6- and 12-month follow-up. Abstinence rates at 1-, 6- and 12-month follow-up periods were 34%, 18% and 17%, respectively. Results indicated that less smoking during patch treatment, and particularly during weeks 1 through 3, was the most robust predictor of successful abstinence, and this predicted smoking status at all follow-up periods. These results underscore the importance of total abstinence during the cessation process, especially at the outset of treatment, which is paramount to ultimate cessation success. Study limitations and clinical implications are discussed. Adapted from the source document. JF - Journal of Substance Use AU - Harte, Christopher B AU - Watts, Tyler W AU - Meston, Cindy M Y1 - 2013///0, PY - 2013 DA - 0, 2013 SP - 405 EP - 416 PB - Taylor & Francis, Basingstoke UK VL - 18 IS - 5 SN - 1465-9891, 1465-9891 KW - Smoking, smoking cessation, successful abstinence, predictors KW - Abstinence KW - Nicotine patches KW - Smoking KW - Adherence KW - Cessation KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1449098839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Use&rft.atitle=Predictors+of+1-%2C+6-+and+12-month+smoking+cessation+among+a+community-recruited+sample+of+adult+smokers+in+the+United+States&rft.au=Harte%2C+Christopher+B%3BWatts%2C+Tyler+W%3BMeston%2C+Cindy+M&rft.aulast=Harte&rft.aufirst=Christopher&rft.date=2013-01-01&rft.volume=18&rft.issue=5&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Use&rft.issn=14659891&rft_id=info:doi/10.3109%2F14659891.2012.709913 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Smoking; Cessation; Abstinence; Substance abuse; Nicotine patches; Adherence DO - http://dx.doi.org/10.3109/14659891.2012.709913 ER - TY - JOUR T1 - Does substance abuse affect outcomes for trauma-focused treatment of combat-related PTSD? AN - 1449096348; 201324277 AB - Comorbidity of substance use disorders (SUDs) and posttraumatic stress disorder (PTSD) among combat Veterans is common, which creates a need for special consideration of treatment options. Controversy regarding trauma-focused treatments for individuals with comorbid SUDs may cause barriers to treatment delivery. Cognitive processing therapy (CPT) is frequently recommended for treatment of PTSD, but little is known about whether substance use comorbidity affects the outcome. This study compared outcomes for Veterans with PTSD and a substance misuse pattern against Veterans with PTSD without a comorbid SUD, who participated in a six-week residential group CPT treatment program. Lack of significant differences between groups on outcomes for PTSD or depression, p > 0.05, suggests that individuals with comorbid substance misuse have outcomes for PTSD and depression similar to those without substance use comorbidity. Trauma-focused treatments may not be as problematic in this population as many clinicians believe. Attrition and demographic differences between the groups were also explored. Adapted from the source document. JF - Addiction Research & Theory AU - McDowell, Joan AU - Rodriguez, Jessica Y1 - 2013///0, PY - 2013 DA - 0, 2013 SP - 357 EP - 364 PB - Informa HealthCare, Abingdon UK VL - 21 IS - 5 SN - 1606-6359, 1606-6359 KW - PTSD, posttraumatic stress disorder, substance use, comorbidity, cognitive processing therapy KW - Veterans KW - Posttraumatic stress disorder KW - Substance abuse disorders KW - Treatment KW - Comorbidity KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1449096348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+Research+%26+Theory&rft.atitle=Does+substance+abuse+affect+outcomes+for+trauma-focused+treatment+of+combat-related+PTSD%3F&rft.au=McDowell%2C+Joan%3BRodriguez%2C+Jessica&rft.aulast=McDowell&rft.aufirst=Joan&rft.date=2013-01-01&rft.volume=21&rft.issue=5&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Addiction+Research+%26+Theory&rft.issn=16066359&rft_id=info:doi/10.3109%2F16066359.2012.746316 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AREREQ N1 - SubjectsTermNotLitGenreText - Substance abuse; Posttraumatic stress disorder; Comorbidity; Veterans; Treatment; Substance abuse disorders DO - http://dx.doi.org/10.3109/16066359.2012.746316 ER - TY - JOUR T1 - Rural Residence and Adoption of a Novel HIV Therapy in a National, Equal-Access Healthcare System AN - 1448999208; 201308870 AB - Rural persons with HIV face barriers to care that may influence adoption of advances in therapy. We performed a retrospective cohort study to determine rural-urban variation in adoption of raltegravir-the first HIV integrase inhibitor-in national Veterans Afffairs (VA) healthcare. There were 1,222 veterans with clinical indication for raltegravir therapy at time of its FDA approval in October 2007, of whom 223 (19.1%) resided in rural areas. Urban persons were more likely than rural to initiate raltegravir within 180 days (17.3% vs. 11.2%, P = 0.02) and 360 days (27.5% vs. 19.7%, P = 0.02), but this gap narrowed slightly at 720 days (36.3% vs. 31.8%, P = 0.19). In multivariable analysis adjusting for patient characteristics, urban residence predicted raltegravir adoption within 180 days (odds ratio 1.72, 95% CI 1.09-2.70) and 360 days (OR 1.63, 95% CI 1.13-2.34), but not 720 days (OR 1.26, 95% CI 0.84-1.87). Efforts are needed to reduce geographic variation in adoption of advances in HIV therapy. Adapted from the source document. JF - AIDS and Behavior AU - Ohl, Michael AU - Lund, Brian AU - Belperio, Pamela S AU - Goetz, Matthew Bidwell AU - Rimland, David AU - Richardson, Kelly AU - Justice, Amy AU - Perencevich, Eli AU - Vaughan-Sarrazin, Mary AD - VA Office of Rural Health (ORH), Veterans Rural Health Resource Center-Central Region, Iowa City VAMC, Iowa City, IA, USA michael.ohl@va.gov Y1 - 2013/01// PY - 2013 DA - January 2013 SP - 250 EP - 259 PB - Springer, Dordrecht, The Netherlands VL - 17 IS - 1 SN - 1090-7165, 1090-7165 KW - Veterans KW - Urban Areas KW - Acquired Immune Deficiency Syndrome KW - Delivery Systems KW - Patients KW - Rural Areas KW - Health Care Services KW - Residence KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1448999208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Rural+Residence+and+Adoption+of+a+Novel+HIV+Therapy+in+a+National%2C+Equal-Access+Healthcare+System&rft.au=Ohl%2C+Michael%3BLund%2C+Brian%3BBelperio%2C+Pamela+S%3BGoetz%2C+Matthew+Bidwell%3BRimland%2C+David%3BRichardson%2C+Kelly%3BJustice%2C+Amy%3BPerencevich%2C+Eli%3BVaughan-Sarrazin%2C+Mary&rft.aulast=Ohl&rft.aufirst=Michael&rft.date=2013-01-01&rft.volume=17&rft.issue=1&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-011-0107-8 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Rural Areas; Residence; Health Care Services; Urban Areas; Veterans; Patients; Delivery Systems DO - http://dx.doi.org/10.1007/s10461-011-0107-8 ER - TY - JOUR T1 - The Revised Faith Development Scale: An Option For A More Reliable Self-Report Measurement Of Postconventional Religious Reasoning AN - 1438556029; 201341319 AB - The study of spiritual development has been challenged by difficulties with definitions and measurement. Different faith traditions place different values on various aspects of spiritual development, yielding different definitions with implications for the measurement of the construct. This study focuses on measurement of postconventional religious reasoning, which is a specific, measurable aspect of spiritual development with clear parallels in cognitive development. This research focuses on the Revised Faith Development Scale (RFDS), a 16-item Likert instrument that is easier to administer than previous interview measures of postconventional religious reasoning and more reliable than a previously developed self-report measure. Preliminary assessment of convergent validity indicators support the use of the RFDS. Adapted from the source document. JF - Research in the Social Scientific Study of Religion AU - Harris, J Irene AU - Leak, Gary K AD - Minneapolis Veterans Administration Health Care System, University of Minnesota, One Veterans Drive, Minneapolis, MN, 55417 Y1 - 2013///0, PY - 2013 DA - 0, 2013 SP - 1 EP - 13 PB - Brill Academic Publishers, Leiden The Netherlands VL - 24 SN - 1046-8064, 1046-8064 KW - postconventional religious reasoning, faith development, faith development scale KW - Values KW - Cognitive Development KW - Research and Development KW - article KW - 1535: sociology of religion; sociology of religion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438556029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+the+Social+Scientific+Study+of+Religion&rft.atitle=The+Revised+Faith+Development+Scale%3A+An+Option+For+A+More+Reliable+Self-Report+Measurement+Of+Postconventional+Religious+Reasoning&rft.au=Harris%2C+J+Irene%3BLeak%2C+Gary+K&rft.aulast=Harris&rft.aufirst=J&rft.date=2013-01-01&rft.volume=24&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Research+in+the+Social+Scientific+Study+of+Religion&rft.issn=10468064&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Cognitive Development; Values; Research and Development ER - TY - JOUR T1 - Reflections on the Past, Present, and the Future of the Chemical Dependency Treatment Field: Four Unique Perspectives AN - 1417524085; 201306401 AB - Four perspectives of the past, present, and future of the addictions field are provided by the most senior members of Columbia University's Drugs & Society Seminar. Each provides a unique perspective based on their experiences. Adapted from the source document. JF - Alcoholism Treatment Quarterly AU - Carroll, Jerome F X AU - De Leon, George AU - Joseph, Herman AU - Winick, Charles AD - New York Harbor Healthcare System Brooklyn VA Hospital, New York, New York, USA jerome.carroll@va.gov Y1 - 2013/01// PY - 2013 DA - January 2013 SP - 107 EP - 120 PB - Haworth/Taylor & Francis Group, Philadephia, PA VL - 31 IS - 1 SN - 0734-7324, 0734-7324 KW - Seminars KW - Addiction KW - Drug Abuse KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1417524085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism+Treatment+Quarterly&rft.atitle=Reflections+on+the+Past%2C+Present%2C+and+the+Future+of+the+Chemical+Dependency+Treatment+Field%3A+Four+Unique+Perspectives&rft.au=Carroll%2C+Jerome+F+X%3BDe+Leon%2C+George%3BJoseph%2C+Herman%3BWinick%2C+Charles&rft.aulast=Carroll&rft.aufirst=Jerome+F&rft.date=2013-01-01&rft.volume=31&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Alcoholism+Treatment+Quarterly&rft.issn=07347324&rft_id=info:doi/10.1080%2F07347324.2013.746610 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-08-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ATQUE7 N1 - SubjectsTermNotLitGenreText - Addiction; Drug Abuse; Seminars DO - http://dx.doi.org/10.1080/07347324.2013.746610 ER - TY - JOUR T1 - Achieving the Promise of Evidence-Based Psychotherapies for Posttraumatic Stress Disorder and Other Mental Health Conditions for Veterans AN - 1373491270; 201313360 AB - For many years, posttraumatic stress disorder (PTSD) consisted of a poorly understood constellation of symptoms from which there was little hope for meaningful recovery. Today's reality, however, is very different from the circumstances of decades past, offering great promise to individuals with PTSD. Effective mechanisms for disseminating EBPs, such as those underway in VHA, are critical to achieving this promise. Adapted from the source document. JF - Psychological Science in the Public Interest AU - Karlin, Bradley E AU - Agarwal, Madhulika AD - U.S. Department of Veterans Affairs Central Office, 810 Vermont Ave., NW, Washington, DC 20420 bradley.karlin2@va.gov Y1 - 2013///0, PY - 2013 DA - 0, 2013 SP - 62 EP - 64 PB - Sage Publications, Thousand Oaks CA VL - 14 IS - 2 SN - 1529-1006, 1529-1006 KW - Symptoms KW - Posttraumatic stress disorder KW - Evidence based psychiatry KW - Recovery KW - Psychotherapy KW - Hope KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1373491270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Science+in+the+Public+Interest&rft.atitle=Achieving+the+Promise+of+Evidence-Based+Psychotherapies+for+Posttraumatic+Stress+Disorder+and+Other+Mental+Health+Conditions+for+Veterans&rft.au=Karlin%2C+Bradley+E%3BAgarwal%2C+Madhulika&rft.aulast=Karlin&rft.aufirst=Bradley&rft.date=2013-01-01&rft.volume=14&rft.issue=2&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Psychological+Science+in+the+Public+Interest&rft.issn=15291006&rft_id=info:doi/10.1177%2F1529100613484706 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Hope; Psychotherapy; Recovery; Symptoms; Evidence based psychiatry DO - http://dx.doi.org/10.1177/1529100613484706 ER - TY - JOUR T1 - Brief Intervention for Risk-Drinking Women: A Mixed Methods Analysis of Content and Process AN - 1347816824; 201305971 AB - Background and Objectives: Although brief interventions (BIs) are among the most highly promoted treatments for alcohol problems, their effective components are unknown. This may be particularly important when considering women since some reviews have suggested that BIs are more efficacious among men. The purpose of this pilot study is to utilize a mixed methods and gender analysis approach to generate hypotheses about the effective components of BIs given to women with medical problems exacerbated by problem drinking. Methods: Random sample of 20 BIs given to women with diabetes, hypertension, infertility, or osteoporosis. Quantitative and qualitative analytic methods were undertaken in a stepwise progression, followed by a gender analysis using the Worldview Assessment Framework. Results: Main findings include that a worldview encompassing drinking as an entitlement may be a moderator limiting the effectiveness of a BI, that understanding the impact of alcohol on infertility problems as distinct from prenatal alcohol use may be a mediator for BI effectiveness, and that providing information about sensible drinking limits in the context of a specific medical problem was feasible. Conclusions and Significance: Content and process areas are important to consider when offering BI for risk-drinking women with medical problems and may help to improve treatment efficacy in this group. Adapted from the source document. JF - The American Journal on Addictions AU - DeMarinis, Valerie AU - Caplan, Jason AU - Chang, Grace AD - Department of Veterans Affairs (116A), 940 Belmont Street, Brockton, MA 02301 Y1 - 2013/01// PY - 2013 DA - January 2013 SP - 67 EP - 74 PB - Wiley Subscription Services, Inc. VL - 22 IS - 1 SN - 1055-0496, 1055-0496 KW - Alcohol consumption KW - Worldview KW - Alcohol related problems KW - Women KW - Brief interventions KW - Gender differences KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1347816824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+on+Addictions&rft.atitle=Brief+Intervention+for+Risk-Drinking+Women%3A+A+Mixed+Methods+Analysis+of+Content+and+Process&rft.au=DeMarinis%2C+Valerie%3BCaplan%2C+Jason%3BChang%2C+Grace&rft.aulast=DeMarinis&rft.aufirst=Valerie&rft.date=2013-01-01&rft.volume=22&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+on+Addictions&rft.issn=10550496&rft_id=info:doi/10.1111%2Fj.1521-0391.2013.00331.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Women; Alcohol consumption; Gender differences; Brief interventions; Alcohol related problems; Worldview DO - http://dx.doi.org/10.1111/j.1521-0391.2013.00331.x ER - TY - JOUR T1 - Activation thresholds and operating characteristics of commercial alarm products to provide surveillance for dementia caregivers AN - 1347816722; 201305490 AB - Objective A laboratory evaluation was conducted on selected commercial technologies designed to prevent or manage dementia-related missing incidents from the home. Methods Fourteen products representing four unique categories (Pressure Activated Systems, Pull Tab Alarms, Audible Alarms, and Optically Activated Alarms) of behavioral management were evaluated under controlled laboratory conditions for: sound pressure levels (dB), power consumption (watts), battery life, and alarm frequency (pitch). Other variables such as activation force and monitoring/tracking capabilities were tested where applicable to the device category. Results There was wide performance variability regardless of device category, indicating that the devices may fail to successfully capture a missing incident. Implications The development of standardized protocols for testing devices intended for use in the home setting coupled with a broader evaluation of existing technologies would provide a more complete understanding of which products may manage or inhibit missing incidents in persons with dementia. Adapted from the source document. JF - Gerontechnology AU - Applegarth, Shawn P AU - Rowe, Meredeth AU - Kearns, William AU - Bowen, Mary E AD - James A. Haley Veterans Hospital, HSR&D/RR&D Center of Excellence, Tampa, Florida, USA Y1 - 2013///0, PY - 2013 DA - 0, 2013 SP - 480 EP - 487 PB - International Society for Gerontechnology, Helsinki, Finland VL - 11 IS - 3 SN - 1569-1101, 1569-1101 KW - executive function deficits, wayfinding, surveillance, wandering KW - Laboratories KW - Alarms KW - Dementia KW - Surveillance KW - Tracking KW - Technology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1347816722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gerontechnology&rft.atitle=Activation+thresholds+and+operating+characteristics+of+commercial+alarm+products+to+provide+surveillance+for+dementia+caregivers&rft.au=Applegarth%2C+Shawn+P%3BRowe%2C+Meredeth%3BKearns%2C+William%3BBowen%2C+Mary+E&rft.aulast=Applegarth&rft.aufirst=Shawn&rft.date=2013-01-01&rft.volume=11&rft.issue=3&rft.spage=480&rft.isbn=&rft.btitle=&rft.title=Gerontechnology&rft.issn=15691101&rft_id=info:doi/10.4017%2Fgt.2013.11.3.007.00 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alarms; Dementia; Laboratories; Technology; Tracking; Surveillance DO - http://dx.doi.org/10.4017/gt.2013.11.3.007.00 ER - TY - JOUR T1 - Urine dipstick analysis for identification of runners susceptible to acute kidney injury following an ultramarathon AN - 1323817973; 17796031 AB - This study examined whether urine dipstick testing might be useful to predict the development of acute kidney injury after an ultramarathon. Participants in the 2011 161-km Western States Endurance Run underwent post-race blood and urine dipstick analyses. Of the 310 race finishers, post-race urine dipstick testing was completed on 152 (49%) and post-race blood also was obtained from 150 of those runners. Based on "injury" and "risk" criteria for acute kidney injury of blood creatinine 2.0 and 1.5 times estimated baseline, respectively, 4% met the criteria for injury and an additional 29-30% met the criteria for risk of injury. Those meeting the injury criteria had higher creatine kinase concentrations (P < 0.001) than those not meeting the criteria. Urine dipstick tests that read positive for at least 1+ protein, 3+ blood, and specific gravity greater than or equal to 1.025 predicted those meeting the injury criteria with sensitivity of 1.00 (95% confidence interval [CI] 0.54-1.00), specificity of 0.76 (95% CI 0.69-0.83), positive predictive value of 0.15 (95% CI 0.06-0.30), negative predictive value of 1.00 (95% CI 0.97-1.00), and likelihood ratio for a positive test of 4.2. We conclude that urine dipstick testing was successfully able to identify those individuals meeting injury criteria for acute kidney injury with excellent sensitivity and specificity. JF - Journal of Sports Sciences AU - Hoffman, Martin D AU - Stuempfle, Kristin J AU - Fogard, Kevin AU - Hew-Butler, Tamara AU - Winger, James AU - Weiss, Robert H AD - Department of Physical Medicine & Rehabilitation, Department of Veterans Affairs, Northern California Health Care System, Sacramento, CA, martin.hoffman@va.gov Y1 - 2013/01/01/ PY - 2013 DA - 2013 Jan 01 SP - 20 EP - 31 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 31 IS - 1 SN - 0264-0414, 0264-0414 KW - Physical Education Index KW - Analysis KW - Injuries KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1323817973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Sports+Sciences&rft.atitle=Urine+dipstick+analysis+for+identification+of+runners+susceptible+to+acute+kidney+injury+following+an+ultramarathon&rft.au=Hoffman%2C+Martin+D%3BStuempfle%2C+Kristin+J%3BFogard%2C+Kevin%3BHew-Butler%2C+Tamara%3BWinger%2C+James%3BWeiss%2C+Robert+H&rft.aulast=Hoffman&rft.aufirst=Martin&rft.date=2013-01-01&rft.volume=31&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Journal+of+Sports+Sciences&rft.issn=02640414&rft_id=info:doi/10.1080%2F02640414.2012.720705 LA - English DB - Physical Education Index N1 - Date revised - 2013-04-01 N1 - Last updated - 2014-03-10 N1 - SubjectsTermNotLitGenreText - Injuries DO - http://dx.doi.org/10.1080/02640414.2012.720705 ER - TY - JOUR T1 - Gulf War Illness: Symptomatology Among Veterans 10 Years After Deployment AN - 1285103758; 17634818 AB - Objective: To further elucidate the nature of illness in veterans of the 1990 to 1991 Gulf War (GW) by examining the GW Illness (GWI) definition advanced by the Centers for Disease Control and Prevention, which specified caseness as having at least one symptom from two of the three factors: fatigue, mood-cognition, and musculoskeletal. Methods: A total of 311 male and female GW veterans drawn from across the nation were assessed in a survey-based study approximately 10 years after deployment. Results: A total of 33.8% of the probability-weighted sample met GWI criteria. Multiple symptom profiles were found, with more than half of GWI cases endorsing a symptom on all the three factors, and almost all cases endorsing at least one mood-cognition symptom. Conclusion: Although the Centers for Disease Control and Prevention definition has some limitations that should be considered, it remains a useful tool for assessing the presence of illness in GW veterans. JF - Journal of Occupational and Environmental Medicine AU - Smith, B N AU - Wang, J M AU - Vogt, D AU - Vickers, K AU - King, D W AU - King, LA AD - Women's Health Sciences Division, National Center for PTSD, VA Boston Healthcare System, 150 S Huntington Ave (116B-3), Boston, MA 02130, USA, Brian.Smith12@va.gov PY - 2013 SP - 104 EP - 110 VL - 55 IS - 1 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Prevention KW - Musculoskeletal system KW - Fatigue KW - War KW - Disease control KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1285103758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Gulf+War+Illness%3A+Symptomatology+Among+Veterans+10+Years+After+Deployment&rft.au=Smith%2C+B+N%3BWang%2C+J+M%3BVogt%2C+D%3BVickers%2C+K%3BKing%2C+D+W%3BKing%2C+LA&rft.aulast=Smith&rft.aufirst=B&rft.date=2013-01-01&rft.volume=55&rft.issue=1&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e318270d709 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Prevention; Fatigue; Musculoskeletal system; War; Disease control DO - http://dx.doi.org/10.1097/JOM.0b013e318270d709 ER - TY - JOUR T1 - Main and interactive effects of social support in predicting mental health symptoms in men and women following military stressor exposure AN - 1285092339; 17576227 AB - Evidence across a multitude of contexts indicates that social support is associated with reduced risk for mental health symptoms. More information is needed on the effectiveness of different sources of support, as well as sex differences in support. Associations between social support from two sources - the military unit and friends and family - and mental health symptoms were examined in a study of 1571 Marine recruits assessed at the beginning and end of a highly stressful 13-week training program. Military social support buffered the stressor exposure-posttraumatic stress symptomatology (PTSS) relationship, whereas the relationship between stressor exposure and PTSS was highest when civilian social support was high. Further inspection of the interactions revealed that military support was most important at high levels of stressor exposure. Sex differences in the relationship between social support and symptoms were found, such that support from military peers was associated with lower levels of PTSS for men, whereas civilian support was associated with lower PTSS for women. While civilian social support was associated with lower levels of depression symptom severity in both women and men, the relationship was stronger for women. Reviewed implications focus on the importance of considering the recipient, source, and context of social support. JF - Anxiety, Stress, and Coping AU - Smith, Brian N AU - Vaughn, Rachel A AU - Vogt, Dawne AU - King, Daniel W AU - King, Lynda A AU - Shipherd, Jillian C AD - Women's Health Sciences Division, National Center for PTSD, VA Boston Healthcare System, 150 South Huntington Avenue, 116B-3, Boston, MA, USA, Brian.Smith12@va.gov Y1 - 2013/01/01/ PY - 2013 DA - 2013 Jan 01 SP - 52 EP - 69 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 26 IS - 1 SN - 1061-5806, 1061-5806 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Females KW - Inspection KW - Males KW - Mental disorders KW - Military KW - Reviews KW - Risk reduction KW - Stress KW - Training KW - H 1000:Occupational Safety and Health KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1285092339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anxiety%2C+Stress%2C+and+Coping&rft.atitle=Main+and+interactive+effects+of+social+support+in+predicting+mental+health+symptoms+in+men+and+women+following+military+stressor+exposure&rft.au=Smith%2C+Brian+N%3BVaughn%2C+Rachel+A%3BVogt%2C+Dawne%3BKing%2C+Daniel+W%3BKing%2C+Lynda+A%3BShipherd%2C+Jillian+C&rft.aulast=Smith&rft.aufirst=Brian&rft.date=2013-01-01&rft.volume=26&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Anxiety%2C+Stress%2C+and+Coping&rft.issn=10615806&rft_id=info:doi/10.1080%2F10615806.2011.634001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-01 N1 - Last updated - 2013-03-11 N1 - SubjectsTermNotLitGenreText - Mental disorders; Training; Reviews; Males; Stress; Females; Risk reduction; Inspection; Military DO - http://dx.doi.org/10.1080/10615806.2011.634001 ER - TY - JOUR T1 - Two consecutive clusters of toxic anterior segment syndrome. AN - 1273717558; 23271338 AB - To present clinical findings and etiologic investigation of two consecutive clusters of toxic anterior segment syndrome (TASS) after uncomplicated phacoemulsification cataract surgery. At the Veterans Affairs Northern Indiana Health Care System Fort Wayne campus, 11 consecutive patients on two separate days in 2011 underwent clear corneal incision phacoemulsification cataract surgery by the same surgeon. On the first postoperative day, all patients had 1+ to 2+ diffuse limbus to limbus stromal edema and 2+ to 4+ anterior chamber white blood cells. Five eyes had inflammatory plaques on the surface of the intraocular implant, six had fibrin, three had hypopyon, and one had inflammatory debris "puff ball." Visual acuity ranged 20/70 to 20/400. Treatment included moxifloxacin four times a day, diclofenac four times a day, and prednisolone acetate 1% every 1 to 2 hours. In all patients, active inflammation and corneal edema resolved within 6 weeks, and visual outcome was 20/20. Cataract surgery was paused for 5 months after the first cluster of TASS and then immediately paused again after restarting because of a second cluster. Although no specific causes were identified, etiologic investigation resulted in the implementation of multiple changes. The changes included new replacement surgical instruments, disposable irrigation/aspirator tip and handle, risk of residue on reusable instruments minimized, preservative-free medications used when available, ophthalmic ointment eliminated, manufacturers' recommendations followed exactly, and eye instruments processed separately. Toxic anterior segment syndrome did not occur when surgery resumed 11 months after the last cluster. There are multiple possible etiologies of TASS. However, as in our clusters, specific causes are often not identified. Thorough review of all steps in surgery, processing of equipment and preparation of injectable solutions and materials, and adoption of best practices can prevent additional cases of TASS. Prompt diagnosis and treatment of TASS are extremely important because this leads to a desirable outcome. JF - Optometry and vision science : official publication of the American Academy of Optometry AU - Moyle, Wendy AU - Yee, Robert D AU - Burns, John K AU - Biggins, Tim AD - Veterans Affairs Northern Indiana Health Care System, Fort Wayne, Indiana 46805, USA. wendy.moyle@va.gov Y1 - 2013/01// PY - 2013 DA - January 2013 SP - e11 EP - e23 VL - 90 IS - 1 KW - Endotoxins KW - 0 KW - Index Medicus KW - Equipment Contamination KW - Aged, 80 and over KW - Syndrome KW - Humans KW - Aged KW - Middle Aged KW - Visual Acuity KW - Male KW - Phacoemulsification KW - Endophthalmitis -- etiology KW - Corneal Edema -- etiology KW - Postoperative Complications KW - Endophthalmitis -- diagnosis KW - Corneal Edema -- diagnosis KW - Anterior Eye Segment -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1273717558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Optometry+and+vision+science+%3A+official+publication+of+the+American+Academy+of+Optometry&rft.atitle=Two+consecutive+clusters+of+toxic+anterior+segment+syndrome.&rft.au=Moyle%2C+Wendy%3BYee%2C+Robert+D%3BBurns%2C+John+K%3BBiggins%2C+Tim&rft.aulast=Moyle&rft.aufirst=Wendy&rft.date=2013-01-01&rft.volume=90&rft.issue=1&rft.spage=e11&rft.isbn=&rft.btitle=&rft.title=Optometry+and+vision+science+%3A+official+publication+of+the+American+Academy+of+Optometry&rft.issn=1538-9235&rft_id=info:doi/10.1097%2FOPX.0b013e318279e991 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-06-11 N1 - Date created - 2012-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/OPX.0b013e318279e991 ER - TY - JOUR T1 - Chronic Obstructive Pulmonary Disease Patients Have Greater Systemic Responsiveness to Ex Vivo Stimulation with Swine Dust Extract and its Components Versus Healthy Volunteers AN - 1272706743; 17528428 AB - Chronic obstructive pulmonary disease (COPD) is characterized by an airway and systemic inflammatory response. Bioaerosols/organic dusts are important agricultural pollutants that may lead to COPD. These environments are complex, containing a rich source of various microbial components. The objective of this study was to determine whether individuals with COPD have enhanced systemic responsiveness to settled swine facility organic dust extract (ODE) or its main pathogenic components (peptidoglycan [PGN], lipopolysaccharide [LPS]) versus healthy volunteers. A modified whole blood assay (WBA) that included occupational levels of ODE and concentrations of LPS and PGN found in ODE was used to determine systemic responsiveness (mediator release), and sputum inflammatory markers were measured to explore for systemic and airway associations. Sputum samples were evaluated for cell counts, and tumor necrosis factor (TNF)- alpha , interleukin (IL)-8/CXCL8, IL-6, and IL-10. Ex vivo whole blood stimulation with ODE, LPS, and PGN each resulted in significant mediator release in all subjects, with the highest occurring with ODE; PGN resulted in significantly enhanced TNF- alpha and IL-8 as compared to LPS. COPD subjects demonstrated greater systemic responsiveness using the modified WBA versus healthy controls. Within COPD subjects, blood baseline TNF- alpha , IL-8, and IL-10 and ODE-, PGN-, and LPS-stimulated IL-8 levels significantly correlated with lung function. In conclusion, dust-induced mediator release was robust, and PGN, in part, resembled dust-induced mediator release. Subjects with COPD demonstrated increased mediator release following ex vivo whole blood stimulation with bioaerosol components, suggesting that circulating blood cells in COPD subjects may be primed to respond greater to microbial/inflammatory insult. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Harting, Janel R AU - Gleason, Angela AU - Romberger, Debra J AU - Von Essen, Susanna G AU - Qiu, Fang AU - Alexis, Neil AU - Poole, Jill A AD - Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA, japoole@unmc.edu Y1 - 2012/12/15/ PY - 2012 DA - 2012 Dec 15 SP - 1456 EP - 1470 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 75 IS - 24 SN - 1528-7394, 1528-7394 KW - Environment Abstracts; Toxicology Abstracts KW - Bioindicators KW - Interleukin 6 KW - Aerosols KW - Airborne microorganisms KW - peptidoglycans KW - Tumors KW - Interleukin 10 KW - Dust KW - Interleukin 8 KW - Inflammation KW - Chronic obstructive pulmonary disease KW - Pollutants KW - Lipopolysaccharides KW - Respiratory function KW - Blood cells KW - Tumor necrosis factor- alpha KW - Sputum KW - Respiratory tract KW - X 24370:Natural Toxins KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1272706743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Chronic+Obstructive+Pulmonary+Disease+Patients+Have+Greater+Systemic+Responsiveness+to+Ex+Vivo+Stimulation+with+Swine+Dust+Extract+and+its+Components+Versus+Healthy+Volunteers&rft.au=Harting%2C+Janel+R%3BGleason%2C+Angela%3BRomberger%2C+Debra+J%3BVon+Essen%2C+Susanna+G%3BQiu%2C+Fang%3BAlexis%2C+Neil%3BPoole%2C+Jill+A&rft.aulast=Harting&rft.aufirst=Janel&rft.date=2012-12-15&rft.volume=75&rft.issue=24&rft.spage=1456&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2012.722186 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Interleukin 6; peptidoglycans; Interleukin 8; Dust; Interleukin 10; Chronic obstructive pulmonary disease; Inflammation; Pollutants; Lipopolysaccharides; Sputum; Tumor necrosis factor- alpha; Blood cells; Respiratory tract; Bioindicators; Aerosols; Airborne microorganisms; Tumors; Respiratory function DO - http://dx.doi.org/10.1080/15287394.2012.722186 ER - TY - JOUR T1 - Understanding the context of patient experiences in order to explore adherence to secondary prevention guidelines after heart surgery AN - 1541978262; 201417173 AB - After coronary artery bypass surgery, many patients do not incorporate healthy behaviors into their postoperative lifestyle or enroll in cardiac rehabilitation, key aspects of secondary prevention. This qualitative study examined patients' post-coronary artery bypass surgery experiences to explore barriers in adhering to dietary and activity guidelines. We conducted semi-structured, in-depth interviews with 30 male patients from a military veteran's hospital, using emergent, thematic analysis to identify experiences that led to poor adherence. Results were grouped according to barriers to diet, activities, and enrolling in cardiac rehabilitation. Overall, understandings of postoperative health, priorities that diverged from guidelines, and the context of household members and other health conditions impacted postoperative health behaviors. Many participants were familiar with secondary prevention guidelines. However, postoperative perceptions of health as well as the context of recovery influenced self-management. Providers must consider a patient's context when discussing secondary prevention. Venues such as cardiac rehabilitation may provide an opportunity to improve adherence to secondary prevention guidelines by expanding available class times, engaging patients' household members, or tailoring recommendations to also address other health conditions. [Reprinted by permission of Sage Publications, Ltd., copyright holder.] JF - Chronic Illness AU - Fix, Gemmae M AU - Bokhour, Barbara G AD - Center for Health Quality, Outcomes and Economic Research, Department of Veterans Affairs, ENMR Veterans Hospital, USA gemmae.fix@va.gov Y1 - 2012/12// PY - 2012 DA - December 2012 SP - 265 EP - 277 PB - Sage Publications, London UK VL - 8 IS - 4 SN - 1742-3953, 1742-3953 KW - Qualitative methods heart surgery secondary prevention self-management adherence KW - Households KW - Secondary prevention KW - Adherence KW - Health KW - Diet KW - Cardiovascular diseases KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541978262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chronic+Illness&rft.atitle=Understanding+the+context+of+patient+experiences+in+order+to+explore+adherence+to+secondary+prevention+guidelines+after+heart+surgery&rft.au=Fix%2C+Gemmae+M%3BBokhour%2C+Barbara+G&rft.aulast=Fix&rft.aufirst=Gemmae&rft.date=2012-12-01&rft.volume=8&rft.issue=4&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Chronic+Illness&rft.issn=17423953&rft_id=info:doi/10.1177%2F1742395312441037 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-07-01 N1 - Number of references - 45 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Secondary prevention; Health; Cardiovascular diseases; Adherence; Households; Diet DO - http://dx.doi.org/10.1177/1742395312441037 ER - TY - JOUR T1 - Constitutive Expression of Human Telomerase Enhances the Proliferation Potential of Human Mesenchymal Stem Cells AN - 1529933424; 19825571 AB - Human mesenchymal stem cells (hMSCs) are highly desirable cells for bone engineering due to the inherent multipotent nature of the cells. Unfortunately, there is a high degree of variability, as primary hMSC cultures quickly undergo replicative senescence with loss of proliferative potential as they are continually propagated in cell culture. We sought to reduce the variability of these cells by insertion and expression of human telomerase reverse transcriptase (TERT) to immortalize the cell line. hMSCs were transduced with a lentivirus containing the human TERT gene. The resulting cell line has been propagated through more than 70 population-doubling level (PDL) to date and continues to grow exhibiting the characteristic fibroblastic hMSC phenotype. Expression of TERT mRNA and protein activity was confirmed in the TERT-transduced cells. Mock-transduced hMSCs had almost undetectable levels of TERT mRNA and protein activity and lost proliferation potential at PDL 14. The enhanced growth capacity of the hMSC TERT cells was due to increased cell proliferation and reduced cellular senescence rather than due to inhibition of apoptosis. The multipotent nature of the TERT cells was confirmed by differentiation toward the osteoblastic and adipogenic lineages in vitro. Osteoblastic differentiation was confirmed by both expression of alkaline phosphate and mineral deposition visualized by Alizarin Red staining. Adipogenic differentiation was confirmed by production of lipid droplets, which were detected by Oil Red-O staining. In summary, we have generated a stable hMSC line that can be continually propagated and retains both osteoblastic and adipogenic differentiation potential. JF - BioResearch Open Access AU - Bischoff, David S AU - Makhijani, Nalini S AU - Yamaguchi, Dean T AD - Research Service, Veterans' Administration Greater Los Angeles Healthcare System, Los Angeles, California. Y1 - 2012/12// PY - 2012 DA - Dec 2012 SP - 273 EP - 279 PB - Mary Ann Liebert, Inc. Publishers, 140 Huguenot St 3rd Fl New Rochelle NY 10801 United States VL - 1 IS - 6 SN - 2164-7860, 2164-7860 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Immunology Abstracts KW - adipogenic differentiation KW - human mesenchymal stem cell KW - osteoblastic differentiation KW - TERT expression KW - Osteoblastogenesis KW - Apoptosis KW - Lipids KW - Cell culture KW - telomerase reverse transcriptase KW - Gene expression KW - Oil KW - Osteoblasts KW - Differentiation KW - Stem cells KW - Lentivirus KW - Phosphate KW - Senescence KW - Cell proliferation KW - Mesenchyme KW - Minerals KW - G 07730:Development & Cell Cycle KW - F 06910:Microorganisms & Parasites KW - W 30945:Fermentation & Cell Culture KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1529933424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioResearch+Open+Access&rft.atitle=Constitutive+Expression+of+Human+Telomerase+Enhances+the+Proliferation+Potential+of+Human+Mesenchymal+Stem+Cells&rft.au=Bischoff%2C+David+S%3BMakhijani%2C+Nalini+S%3BYamaguchi%2C+Dean+T&rft.aulast=Bischoff&rft.aufirst=David&rft.date=2012-12-01&rft.volume=1&rft.issue=6&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=BioResearch+Open+Access&rft.issn=21647860&rft_id=info:doi/10.1089%2Fbiores.2012.0252 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Number of references - 24 N1 - Last updated - 2014-10-30 N1 - SubjectsTermNotLitGenreText - Osteoblastogenesis; Apoptosis; Lipids; Cell culture; telomerase reverse transcriptase; Oil; Gene expression; Differentiation; Osteoblasts; Stem cells; Phosphate; Senescence; Mesenchyme; Cell proliferation; Minerals; Lentivirus DO - http://dx.doi.org/10.1089/biores.2012.0252 ER - TY - JOUR T1 - Cost-effectiveness of linezolid in methicillin-resistant Staphylococcus aureus skin and skin structure infections AN - 1468368398; 18787870 AB - Linezolid is a novel oxazolidinone antibacterial agent with a broad clinical application, especially in methicillin-resistant Staphylococcus aureus skin and soft-tissue infections and skin and skin-structure infections. Pharmacoeconomic advantages include decreased hospital duration, reduction in intravenous antibiotic use and early discharge opportunities that contribute to an overall reduction in healthcare resources. Linezolid's oral formulation has a pharmacokinetic profile that is similar to its intravenous formulation, which creates opportunities for early discharge not available to comparators like vancomycin and daptomycin. Both vancomycin and daptomycin require intravenous therapy, which compounds the resources required in treating methicillin-resistant S. aureus skin and soft tissue/skin and skin structure infections. Pharmacoeconomic studies have demonstrated an overall reduction in total direct costs to the payer in favor of linezolid over its comparators. Its overall reduction in healthcare utilization makes it an appropriate alternative to the standard therapy, vancomycin. JF - Expert Review of Pharmacoeconomics & Outcomes Research AU - Bounthavong, Mark AU - Hsu, Donald I AD - super(1)Veterans Affairs, San Diego Healthcare System, UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, 3350 La Jolla Village Drive (119), San Diego, CA 92161, USA., mark.bounthavong@va.gov Y1 - 2012/12// PY - 2012 DA - Dec 2012 SP - 683 EP - 698 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 12 IS - 6 SN - 1473-7167, 1473-7167 KW - Microbiology Abstracts B: Bacteriology KW - Intravenous administration KW - Skin KW - Pharmacology KW - Drug resistance KW - Therapeutic applications KW - Antibiotics KW - Infection KW - daptomycin KW - Pharmacokinetics KW - oxazolidinones KW - Reviews KW - Economics KW - Vancomycin KW - Staphylococcus aureus KW - Antibacterial agents KW - Soft tissues KW - Linezolid KW - Hospitals KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1468368398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Review+of+Pharmacoeconomics+%26+Outcomes+Research&rft.atitle=Cost-effectiveness+of+linezolid+in+methicillin-resistant+Staphylococcus+aureus+skin+and+skin+structure+infections&rft.au=Bounthavong%2C+Mark%3BHsu%2C+Donald+I&rft.aulast=Bounthavong&rft.aufirst=Mark&rft.date=2012-12-01&rft.volume=12&rft.issue=6&rft.spage=683&rft.isbn=&rft.btitle=&rft.title=Expert+Review+of+Pharmacoeconomics+%26+Outcomes+Research&rft.issn=14737167&rft_id=info:doi/10.1586%2Ferp.12.72 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-12-01 N1 - Number of references - 58 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Intravenous administration; Skin; Pharmacology; Drug resistance; Therapeutic applications; Antibiotics; Infection; Pharmacokinetics; daptomycin; oxazolidinones; Reviews; Economics; Vancomycin; Antibacterial agents; Linezolid; Soft tissues; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1586/erp.12.72 ER - TY - JOUR T1 - Changes in posttraumatic stress disorder and depressive symptoms during cognitive processing therapy: Evidence for concurrent change. AN - 1364765770; 201310227 AB - Objective: Trauma-focused psychotherapies reduce both posttraumatic stress disorder (PTSD) and co-occurring depression. However, little is known about the relationship between changes in PTSD and depression during treatment. This study examined the association between changes in PTSD and depression during the course of cognitive processing therapy (CPT) and its treatment components. Method: Data were drawn from a dismantling trial investigating the comparative efficacy of the components of CPT (Resick, Galovski, et al., 2008). One hundred twenty-six women (mean age = 36.14 years) from the original randomized intent-to-treat sample (N = 150) who attended at least 1 treatment session were included in this study. Participants diagnosed with PTSD were assigned to 1 of 3 treatment conditions: the full CPT protocol (n = 44), the cognitive therapy component of CPT (n = 39), and the written account component of CPT (n = 43). The majority of the sample self-identified as Caucasian (67%; 29% African American and 4% Other). Primary outcome measures included the Posttraumatic Diagnostic Scale and Beck Depression Inventory-II, administered at 8 time points (baseline, weekly throughout 6 weeks of treatment, and posttreatment). Results: Multilevel regression analyses were conducted to examine relationships between PTSD and depression during treatment. Results indicated that changes in PTSD and depression were strongly related. Multilevel mediation analyses revealed that changes in PTSD and depression occurred concurrently, with lagged analyses providing no evidence that changes in symptoms of 1 disorder preceded changes in the other. Conclusions: Results suggest that changes in PTSD and depression occur contemporaneously during CPT. [Copyright American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Liverant, Gabrielle I AU - Suvak, Michael K AU - Pineles, Suzanne L AU - Resick, Patricia A AD - VA Boston Healthcare System-Brockton Campus, Brockton, MA, US gabrielle.liverant@va.gov Y1 - 2012/12// PY - 2012 DA - December 2012 SP - 957 EP - 967 PB - American Psychological Association, Washington DC VL - 80 IS - 6 SN - 0022-006X, 0022-006X KW - PTSD KW - cognitive processing therapy KW - depression KW - psychotherapy KW - treatment KW - Depression KW - Posttraumatic stress disorder KW - Women KW - Cognitive therapy KW - Mediation KW - Cognitive processing KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1364765770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=Changes+in+posttraumatic+stress+disorder+and+depressive+symptoms+during+cognitive+processing+therapy%3A+Evidence+for+concurrent+change.&rft.au=Liverant%2C+Gabrielle+I%3BSuvak%2C+Michael+K%3BPineles%2C+Suzanne+L%3BResick%2C+Patricia+A&rft.aulast=Liverant&rft.aufirst=Gabrielle&rft.date=2012-12-01&rft.volume=80&rft.issue=6&rft.spage=957&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2Fa0030485 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Depression; Cognitive processing; Cognitive therapy; Mediation; Women DO - http://dx.doi.org/10.1037/a0030485 ER - TY - JOUR T1 - Budget Impact Analysis of HIV Testing in the VA Healthcare System AN - 1347816572; 201305466 AB - Objectives: The long-term cost effectiveness of routine HIV testing is favorable relative to other medical interventions. Facility-specific costs of expanded HIV testing and care for newly identified patients, however, are less well defined. To aid in resource allocation decisions, we developed a spreadsheet-based budget-impact tool populated with estimates of facility-specific HIV testing and care costs incurred with an expanded testing program. Methods: We modeled intervention effects on quarterly costs of antiretroviral therapy (ART), outpatient resource utilization, and staff expenditures in the Department of Veterans Affairs over a 2-year period of increasing HIV testing rates. We used HIV prevalence estimates, screening rates, counseling, positive tests, Veterans Affairs treatment, and published sources as inputs. We evaluated a single-facility cohort of 20,000 patients and at baseline assumed a serodiagnostic rate of 0.45%. Results: Expanding testing from 2% to 15% annually identified 21 additional HIV-positive patients over 2 years at a cost of approximately $290,000, more than 60% of which was due to providing ART to newly diagnosed patients. While quarterly testing costs decreased longitudinally as fewer persons required testing, quarterly ART costs increased from $10,000 to more than $60,000 over 2 years as more infected patients were identified and started on ART. In sensitivity analyses, serodiagnostic and annual HIV testing rates had the greatest cost impact. Conclusions: Expanded HIV testing costs are greatest during initial implementation and predominantly due to ART for new patients. Cost determinations of expanded HIV testing provide an important tool for managers charged with allocating resources within integrated systems providing both HIV testing and care. Adapted from the source document. JF - Value in Health AU - Anaya, Henry D AU - Chan, Kee AU - Karmarkar, Uday AU - Asch, Steven M AU - Goetz, Matthew Bidwell AD - Center for the Study of Healthcare Provider Behavior, VA Greater Los Angeles Health Services Research and Development Center of Excellence, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, 111G Los Angeles, CA 90073 henry.anaya@va.gov Y1 - 2012/12// PY - 2012 DA - December 2012 SP - 1022 EP - 1028 PB - Elsevier Inc., Amsterdam, The Netherlands VL - 15 IS - 8 SN - 1098-3015, 1098-3015 KW - budget impact analysis, cost-effectiveness, facility costs, HIV testing KW - Veterans KW - Sensitivity analysis KW - Interventions KW - Antiretroviral therapy KW - Testing KW - HIV KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1347816572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Value+in+Health&rft.atitle=Budget+Impact+Analysis+of+HIV+Testing+in+the+VA+Healthcare+System&rft.au=Anaya%2C+Henry+D%3BChan%2C+Kee%3BKarmarkar%2C+Uday%3BAsch%2C+Steven+M%3BGoetz%2C+Matthew+Bidwell&rft.aulast=Anaya&rft.aufirst=Henry&rft.date=2012-12-01&rft.volume=15&rft.issue=8&rft.spage=1022&rft.isbn=&rft.btitle=&rft.title=Value+in+Health&rft.issn=10983015&rft_id=info:doi/10.1016%2Fj.jval.2012.08.2205 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - HIV; Testing; Antiretroviral therapy; Veterans; Interventions; Sensitivity analysis DO - http://dx.doi.org/10.1016/j.jval.2012.08.2205 ER - TY - JOUR T1 - Friedreich's Ataxia Causes Redistribution of Iron, Copper, and Zinc in the Dentate Nucleus AN - 1257758475; 17446004 AB - Friedreich's ataxia (FRDA) causes selective atrophy of the large neurons of the dentate nucleus (DN). High iron (Fe) concentration and failure to clear the metal from the affected brain tissue are potential risk factors in the progression of the lesion. The DN also contains relatively high amounts of copper (Cu) and zinc (Zn), but the importance of these metals in FRDA has not been established. This report describes nondestructive quantitative X-ray fluorescence (XRF) and "mapping" of Fe, Cu, and Zn in polyethylene glycol-dimethylsulfoxide (PEG/DMSO)-embedded DN of 10 FRDA patients and 13 controls. Fe fluorescence arose predominantly from the hilar white matter, whereas Cu and Zn were present at peak levels in DN gray matter. Despite collapse of the DN in FRDA, the location of the peak Fe signal did not change. In contrast, the Cu and Zn regions broadened and overlapped extensively with the Fe-rich region. Maximal metal concentrations did not differ from normal (in micrograms per milliliter of solid PEG/DMSO as means plus or minus S.D.): Fe normal, 364 plus or minus 117, FRDA, 344 plus or minus 159; Cu normal, 33 plus or minus 13, FRDA, 33 plus or minus 18; and Zn normal, 32 plus or minus 16, FRDA, 33 plus or minus 19. Tissues were recovered from PEG/DMSO and transferred into paraffin for matching with immunohistochemistry of neuron-specific enolase (NSE), glutamic acid decarboxylase (GAD), and ferritin. NSE and GAD reaction products confirmed neuronal atrophy and grumose degeneration that coincided with abnormally diffuse Cu and Zn zones. Ferritin immunohistochemistry matched Fe XRF maps, revealing the most abundant reaction product in oligodendroglia of the DN hilus. In FRDA, these cells were smaller and more numerous than normal. In the atrophic DN gray matter of FRDA, anti-ferritin labeled mostly hypertrophic microglia. Immunohistochemistry and immunofluorescence of the Cu-responsive proteins Cu,Zn-superoxide dismutase and Cu super(++)-transporting ATPase alpha -peptide did not detect specific responses to Cu redistribution in FRDA. In contrast, metallothionein (MT)-positive processes were more abundant than normal and contributed to the gliosis of the DN. The isoforms of MT, MT-1/2, and brain-specific MT-3 displayed only limited co-localization with glial fibrillary acidic protein. The results suggest that MT can provide effective protection against endogenous Cu and Zn toxicity in FRDA, similar to the neuroprotective sequestration of Fe in holoferritin. JF - Cerebellum AU - Koeppen, Arnulf H AU - Ramirez, RLiane AU - Yu, Devin AU - Collins, Sarah E AU - Qian, Jiang AU - Parsons, Patrick J AU - Yang, Karl X AU - Chen, Zewu AU - Mazurkiewicz, Joseph E AU - Feustel, Paul J AD - Research Service (151), Veterans Affairs Medical Center, 113 Holland Ave, Albany, NY, 12208, USA, Arnulf.Koeppen@med.va.gov Y1 - 2012/12// PY - 2012 DA - Dec 2012 SP - 845 EP - 860 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 11 IS - 4 SN - 1473-4222, 1473-4222 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Paraffin KW - Fluorescence KW - Adenosinetriphosphatase KW - Heavy metals KW - Polyethylene KW - Cerebellum KW - Glial fibrillary acidic protein KW - Copper KW - Toxicity KW - Friedreich's ataxia KW - Zinc KW - Ferritin KW - Atrophy KW - Dentate nucleus KW - Iron KW - Immunohistochemistry KW - Polyethylene glycol KW - Substantia grisea KW - Glutamate decarboxylase KW - X 24360:Metals KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1257758475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cerebellum&rft.atitle=Friedreich%27s+Ataxia+Causes+Redistribution+of+Iron%2C+Copper%2C+and+Zinc+in+the+Dentate+Nucleus&rft.au=Koeppen%2C+Arnulf+H%3BRamirez%2C+RLiane%3BYu%2C+Devin%3BCollins%2C+Sarah+E%3BQian%2C+Jiang%3BParsons%2C+Patrick+J%3BYang%2C+Karl+X%3BChen%2C+Zewu%3BMazurkiewicz%2C+Joseph+E%3BFeustel%2C+Paul+J&rft.aulast=Koeppen&rft.aufirst=Arnulf&rft.date=2012-12-01&rft.volume=11&rft.issue=4&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Cerebellum&rft.issn=14734222&rft_id=info:doi/10.1007%2Fs12311-012-0383-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2014-06-12 N1 - SubjectsTermNotLitGenreText - Paraffin; Adenosinetriphosphatase; Fluorescence; Heavy metals; Polyethylene; Glial fibrillary acidic protein; Cerebellum; Toxicity; Copper; Friedreich's ataxia; Zinc; Atrophy; Ferritin; Dentate nucleus; Polyethylene glycol; Immunohistochemistry; Iron; Glutamate decarboxylase; Substantia grisea DO - http://dx.doi.org/10.1007/s12311-012-0383-5 ER - TY - JOUR T1 - Traumatic brain injury, executive functioning, and suicidal behavior: A brief report AN - 1438671084; 201321161 AB - Objective: The aim of this pilot study was to explore the relationship between executive dysfunction and suicidal behavior in two groups of participants: (Group 1, n = 18) veterans with traumatic brain injury (TBI) and a history of at least one suicide attempt (SA), and (Group 2, n = 29) veterans with TBI and no history of SA. Controlling for the severity of TBI, it was hypothesized that participants in Group 1 would perform more poorly than those in Group 2 on measures of executive functioning. Design: The primary outcome variable was decision making as assessed by performance on the Iowa Gambling Task (IGT). Secondary outcome variables included laboratory-measured impulsivity as measured by the Immediate and Delayed Memory Test (IMT/DMT), abstract reasoning as measured by the Wisconsin Card Sorting Test (WCST), and aggression as measured by the Lifetime History of Aggression (LHA) scale. Results: Among those in Group 1, time between TBI and first suicide attempt postinjury varied widely (months to nearly 30 years). Only the WCST perseverative errors score differed significantly between individuals with and without histories of one or more suicide attempts (SAs). Conclusion: Suggestions for future study of SA among those with TBI are provided. When working with individuals with TBI, clinicians are encouraged to incorporate suicide risk assessment into their practice. Augmenting this process with a measure of perseveration may be beneficial. [Copyright The American Psychological Association.] JF - Rehabilitation Psychology AU - Homaifar, Beeta Y AU - Brenner, Lisa A AU - Forster, Jeri E AU - Nagamoto, Herbert Y1 - 2012/11// PY - 2012 DA - November 2012 SP - 337 EP - 341 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 57 IS - 4 SN - 0090-5550, 0090-5550 KW - executive functioning KW - perseveration KW - suicidal ideation KW - suicide attempt KW - traumatic brain injury KW - veterans KW - Veterans KW - Suicidal behaviour KW - Dysfunction KW - Traumatic brain injury KW - Aggression KW - Executive function KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438671084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rehabilitation+Psychology&rft.atitle=Traumatic+brain+injury%2C+executive+functioning%2C+and+suicidal+behavior%3A+A+brief+report&rft.au=Homaifar%2C+Beeta+Y%3BBrenner%2C+Lisa+A%3BForster%2C+Jeri+E%3BNagamoto%2C+Herbert&rft.aulast=Homaifar&rft.aufirst=Beeta&rft.date=2012-11-01&rft.volume=57&rft.issue=4&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Rehabilitation+Psychology&rft.issn=00905550&rft_id=info:doi/10.1037%2Fa0030480 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Suicidal behaviour; Executive function; Aggression; Traumatic brain injury; Veterans; Dysfunction DO - http://dx.doi.org/10.1037/a0030480 ER - TY - JOUR T1 - Subsyndromal posttraumatic stress disorder symptomatology in primary care military veterans: Treatment implications. AN - 1373492840; 201313436 AB - Subsyndromal posttraumatic stress disorder (PTSD) is highly prevalent in Veterans Affairs Medical Centers' primary-care clinics and is associated with significant impairment. We used a cross-sectional design to examine PTSD symptoms and depressive disorders endorsed by two cohorts of Veterans meeting less than full PTSD criteria who presented to primary care at the Philadelphia VA Medical Center (i.e., those from Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) and non-OEF/OIF/OND Veterans). The Philadelphia VA Behavioral Health Lab (BHL) assessed 141 Veterans who screened positive for subsyndromal PTSD. Avoidance was endorsed significantly less often than arousal in the total group. When the groups were split by cohort era, higher levels of avoidance and lower levels of arousal were reported in the non-OEF/OIF/OND group than the OEF/OIF/OND group. Comorbid depression was present in 43.9% of the total group with no significant differences between groups. Exposure-based treatments for PTSD offered in specialty mental health clinics target avoidance symptoms. Because the endorsement of avoidance symptoms was low in both of the cohorts that were studied this may not be the most effective treatment target for Veterans with subsyndromal PTSD receiving treatment in primary care settings. For these Veterans, treatments that target reexperiencing and arousal symptoms and/or comorbid depression may be more effective. [Copyright Elsevier B.V.] JF - Psychological Services AU - Kornfield, Sara L AU - Klaus, Johanna AU - McKay, Caroline AU - Helstrom, Amy AU - Oslin, David Y1 - 2012/11// PY - 2012 DA - November 2012 SP - 383 EP - 389 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 9 IS - 4 SN - 1541-1559, 1541-1559 KW - PTSD and comorbid depression KW - brief PTSD treatment KW - primary care mental health integration KW - subsyndromal PTSD KW - military veterans KW - posttraumatic stress disorder KW - Veterans KW - Symptoms KW - Posttraumatic stress disorder KW - Arousal KW - Avoidance KW - Primary health care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1373492840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Subsyndromal+posttraumatic+stress+disorder+symptomatology+in+primary+care+military+veterans%3A+Treatment+implications.&rft.au=Kornfield%2C+Sara+L%3BKlaus%2C+Johanna%3BMcKay%2C+Caroline%3BHelstrom%2C+Amy%3BOslin%2C+David&rft.aulast=Kornfield&rft.aufirst=Sara&rft.date=2012-11-01&rft.volume=9&rft.issue=4&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0028082 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Veterans; Symptoms; Primary health care; Avoidance; Arousal DO - http://dx.doi.org/10.1037/a0028082 ER - TY - JOUR T1 - Adapting the multifamily group model for treating veterans with posttraumatic stress disorder. AN - 1373491644; 201314348 AB - The Department of Veterans Affairs (VA) health care system's leadership has endorsed family involvement in veterans' mental health care as an important component of treatment. Both veterans and families describe family participation as highly desirable, and research has documented that having healthy social support is a strong protective factor for posttraumatic stress disorder (PTSD). Family psychoeducation has been shown to be effective in preventing relapse among severely mentally ill, and preliminary evidence suggests that family interventions for PTSD may improve veteran and family outcomes. The multifamily group (MFG) treatment model incorporates psychoeducation, communication training, and problem-solving skill building, and it increases social support through its group format. This article describes the rationale for further adaptation of the MFG model for PTSD, and it reviews issues related to its implementation as a promising adjunctive treatment as part of the continuum of PTSD services available in VA. [Copyright Elsevier B.V.] JF - Psychological Services AU - Sherman, Michelle D AU - Perlick, Deborah A AU - Straits-Troster, Kristy Y1 - 2012/11// PY - 2012 DA - November 2012 SP - 349 EP - 360 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 9 IS - 4 SN - 1541-1559, 1541-1559 KW - PTSD KW - family psychoeducation KW - multifamily groups KW - traumatic brain injury KW - veterans KW - posttraumatic stress disorder KW - mental health care KW - Veterans KW - Posttraumatic stress disorder KW - Social support KW - Psychoeducational treatment KW - Treatment methods KW - Leadership KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1373491644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Adapting+the+multifamily+group+model+for+treating+veterans+with+posttraumatic+stress+disorder.&rft.au=Sherman%2C+Michelle+D%3BPerlick%2C+Deborah+A%3BStraits-Troster%2C+Kristy&rft.aulast=Sherman&rft.aufirst=Michelle&rft.date=2012-11-01&rft.volume=9&rft.issue=4&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0028963 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Veterans; Psychoeducational treatment; Social support; Leadership; Treatment methods DO - http://dx.doi.org/10.1037/a0028963 ER - TY - JOUR T1 - Is computerized cognitive-behavioural therapy a treatment option for depression in late-life? A systematic review AN - 1283740583; 201300907 AB - Objective. Computerized cognitive-behavioural therapy (CCBT) may enhance older adults' access to evidence-based depression treatment. Our objective was to determine the extent to which adults aged 65 years and older are represented in existing studies of CCBT for depression and describe available data on recruitment, retention, and outcomes. Methods. We retrieved all controlled and uncontrolled trials of CCBT for depression published between 2000 and 2010. We obtained data on older adults via the article text or correspondence with authors. Results. Older adults comprised approximately 3% of study participants in reviewed studies. Authors reported that older participants may be less likely than younger adults to drop out, but more likely to experience technical challenges. Conclusions. Older adults are under-represented in studies of CCBT for depression. Adapted from the source document. JF - British Journal of Clinical Psychology AU - Crabb, Rebecca M AU - Cavanagh, Kate AU - Proudfoot, Judy AU - Learmonth, Despina AU - Rafie, Samantha AU - Weingardt, Kenneth R AD - Center for Health Care Evaluation, VA Palo Alto Health Care System and Stanford University School of Medicine, 795 Willow Rd. (152), Menlo Park, CA, 94025, USA Y1 - 2012/11// PY - 2012 DA - November 2012 SP - 459 EP - 464 PB - John Wiley & Sons, Inc. VL - 51 IS - 4 SN - 0144-6657, 0144-6657 KW - Cognitive behaviour therapy KW - Elderly people KW - Depression KW - Recruitment KW - Retention KW - Evidence based medicine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1283740583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Clinical+Psychology&rft.atitle=Is+computerized+cognitive-behavioural+therapy+a+treatment+option+for+depression+in+late-life%3F+A+systematic+review&rft.au=Crabb%2C+Rebecca+M%3BCavanagh%2C+Kate%3BProudfoot%2C+Judy%3BLearmonth%2C+Despina%3BRafie%2C+Samantha%3BWeingardt%2C+Kenneth+R&rft.aulast=Crabb&rft.aufirst=Rebecca&rft.date=2012-11-01&rft.volume=51&rft.issue=4&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Clinical+Psychology&rft.issn=01446657&rft_id=info:doi/10.1111%2Fj.2044-8260.2012.02038.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BJCPDW N1 - SubjectsTermNotLitGenreText - Elderly people; Depression; Cognitive behaviour therapy; Recruitment; Retention; Evidence based medicine DO - http://dx.doi.org/10.1111/j.2044-8260.2012.02038.x ER - TY - CPAPER T1 - Homeless Incidence and Risk Factors for Becoming Homeless in Veterans T2 - 140th American Public Health Association Annual Meeting and Exposition (APHA 2012) AN - 1313119922; 6157231 JF - 140th American Public Health Association Annual Meeting and Exposition (APHA 2012) AU - Clegg, Lin AU - Daigh Jr, David Y1 - 2012/10/27/ PY - 2012 DA - 2012 Oct 27 KW - homelessness KW - Risk factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313119922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=140th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2012%29&rft.atitle=Homeless+Incidence+and+Risk+Factors+for+Becoming+Homeless+in+Veterans&rft.au=Clegg%2C+Lin%3BDaigh+Jr%2C+David&rft.aulast=Clegg&rft.aufirst=Lin&rft.date=2012-10-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=140th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2012%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/140am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Facilitators/Barriers to Pressure Ulcer Prevention (PUP) in Nursing Home Community Living Centers (CLCs) T2 - 140th American Public Health Association Annual Meeting and Exposition (APHA 2012) AN - 1313073754; 6158135 JF - 140th American Public Health Association Annual Meeting and Exposition (APHA 2012) AU - Magnabosco, Jennifer Y1 - 2012/10/27/ PY - 2012 DA - 2012 Oct 27 KW - Prevention KW - Nursing KW - Ulcers KW - Pressure KW - Barriers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313073754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=140th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2012%29&rft.atitle=Facilitators%2FBarriers+to+Pressure+Ulcer+Prevention+%28PUP%29+in+Nursing+Home+Community+Living+Centers+%28CLCs%29&rft.au=Magnabosco%2C+Jennifer&rft.aulast=Magnabosco&rft.aufirst=Jennifer&rft.date=2012-10-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=140th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2012%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/140am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Anorally bioavailable derivative of the neurochemical lanthionine ketimine improves cognition and reduces late-stage pathology in the 3xTg-AD mouse T2 - 42nd Annual Meeting of the Society for Neuroscience (Neuroscience 2012) AN - 1313105770; 6176871 JF - 42nd Annual Meeting of the Society for Neuroscience (Neuroscience 2012) AU - Harris-White, M AU - Hensley, K AU - Johnson, M AU - Eslami, P AU - Venkova-Hristova, K AU - Hristov, A AU - Zemlan, F AU - Gabbita, S Y1 - 2012/10/13/ PY - 2012 DA - 2012 Oct 13 KW - Pathology KW - Bioavailability KW - Cognitive ability KW - Cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313105770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=42nd+Annual+Meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2012%29&rft.atitle=Anorally+bioavailable+derivative+of+the+neurochemical+lanthionine+ketimine+improves+cognition+and+reduces+late-stage+pathology+in+the+3xTg-AD+mouse&rft.au=Harris-White%2C+M%3BHensley%2C+K%3BJohnson%2C+M%3BEslami%2C+P%3BVenkova-Hristova%2C+K%3BHristov%2C+A%3BZemlan%2C+F%3BGabbita%2C+S&rft.aulast=Harris-White&rft.aufirst=M&rft.date=2012-10-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=42nd+Annual+Meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2012/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Obesity in Children and Adolescents: A Webliography AN - 1541448954; 19832262 AB - Overweight and obesity are significant public health problems in the United States. The number of obese or overweight children and adolescents has reached epidemic levels in recent years. Children and adolescents who are overweight or obese are at increased risk for serious health conditions, many of which were formerly considered adult conditions. Even very young children are at risk of becoming obese. Efforts to prevent and control obesity must involve both parents and the community. There are many web resources available to assist in this endeavor. JF - Journal of Consumer Health on the Internet AU - Stephenson, Priscilla L AU - Taylor, Mary Virginia AD - VA Medical Center, Philadelphia, Pennsylvania, USA, Priscilla.Stephensonn@va.gov Y1 - 2012/10/01/ PY - 2012 DA - 2012 Oct 01 SP - 440 EP - 449 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 16 IS - 4 SN - 1539-8285, 1539-8285 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Obesity KW - USA KW - Children KW - Adolescents KW - Public health KW - H 9000:Consumer and Recreation Safety KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541448954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consumer+Health+on+the+Internet&rft.atitle=Obesity+in+Children+and+Adolescents%3A+A+Webliography&rft.au=Stephenson%2C+Priscilla+L%3BTaylor%2C+Mary+Virginia&rft.aulast=Stephenson&rft.aufirst=Priscilla&rft.date=2012-10-01&rft.volume=16&rft.issue=4&rft.spage=440&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consumer+Health+on+the+Internet&rft.issn=15398285&rft_id=info:doi/10.1080%2F15398285.2012.726049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Obesity; Children; Adolescents; Public health; USA DO - http://dx.doi.org/10.1080/15398285.2012.726049 ER - TY - JOUR T1 - National dissemination of cognitive behavioral therapy for depression in the department of veterans affairs health care system: Therapist and patient-level outcomes. AN - 1364765652; 201309875 AB - Objective: The Department of Veterans Affairs (VA) health care system is nationally disseminating and implementing cognitive behavioral therapy for depression (CBT-D). The current article evaluates therapist and patient-level outcomes associated with national training in and implementation of CBT-D in the VA health care system. Method: Therapist competencies were assessed with the Cognitive Therapy Rating Scale (CTRS). Patient outcomes were assessed with the Beck Depression Inventory-II and the World Health Organization Quality of Life-BREF. Therapeutic alliance was assessed with the Working Alliance Inventory-Short Revised. Two-hundred twenty-one therapists have received training, and 356 veteran patients have received treatment through the VA CBT-D Training Program. Results: Of therapists who have participated in the program, 182 (82%) completed all training requirements and achieved competency, reflected by a score of 40 on the CTRS. Of 356 patients, nearly 70% completed 10 or more sessions or improved sufficiently to stop therapy before the 10th session. Mean depression scores decreased by approximately 40% from initial to later treatment phase. Effect sizes of changes ranged from d = 0.39 to d = 0.74 for quality of life and from d = 0.47 to d = 0.66 for therapeutic alliance measures. Conclusion: National training in and implementation of CBT-D within the VA health care system is associated with significant, positive therapist training outcomes, as evidenced by increases in CBT core competencies. The implementation of the protocol by newly trained CBT-D therapists is associated with significantly improved patient outcomes, as evidenced by large decreases in depression and improvements in quality of life. [Copyright American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Karlin, Bradley E AU - Brown, Gregory K AU - Trockel, Mickey AU - Cunning, Darby AU - Zeiss, Antonette M AU - Taylor, C Barr AD - National Mental Health Director, Psychotherapy and Psychogeriatrics, Office of Mental Health Services (10P4M), U.S. Department of Veterans Affairs Central Office, Washington, DC, US bradley.karlin2@va.gov Y1 - 2012/10// PY - 2012 DA - October 2012 SP - 707 EP - 718 PB - American Psychological Association, Washington DC VL - 80 IS - 5 SN - 0022-006X, 0022-006X KW - cognitive behavioral therapy KW - depression KW - dissemination KW - psychotherapy training KW - veterans KW - Department of Veterans Affairs KW - health care system KW - Veterans KW - Cognitive behaviour therapy KW - Depression KW - Health care KW - Therapeutic alliances KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1364765652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=National+dissemination+of+cognitive+behavioral+therapy+for+depression+in+the+department+of+veterans+affairs+health+care+system%3A+Therapist+and+patient-level+outcomes.&rft.au=Karlin%2C+Bradley+E%3BBrown%2C+Gregory+K%3BTrockel%2C+Mickey%3BCunning%2C+Darby%3BZeiss%2C+Antonette+M%3BTaylor%2C+C+Barr&rft.aulast=Karlin&rft.aufirst=Bradley&rft.date=2012-10-01&rft.volume=80&rft.issue=5&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2Fa0029328 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Depression; Health care; Veterans; Cognitive behaviour therapy; Quality of life; Therapeutic alliances DO - http://dx.doi.org/10.1037/a0029328 ER - TY - JOUR T1 - Adaptive institutional transference in the treatment of individuals with borderline personality disorder AN - 1347816797; 201306901 AB - The author introduces "adaptive institutional transference" (AIT) and describes how it develops in some patients in response to psychotherapist transfer in psychology training clinics. Individuals with borderline personality disorder are especially likely to develop AIT because of difficulties related to abandonment depression. Directors, supervisors, and student psychotherapists in a variety of training settings should be aware of these dynamics because of their important treatment implications, which are described. Limitations and ideas for future exploratory and qualitative research are also discussed. Adapted from the source document. JF - Bulletin of the Menninger Clinic AU - Matarazzo, Bridget B AD - VA VISN 19 MIRECC, Denver VAMC, 1055 Clermont Street, Denver, CO 80220 Bridget.Matarazzo@va.gov Y1 - 2012/10// PY - 2012 DA - October 2012 SP - 297 EP - 313 PB - Guilford Publications, New York NY VL - 76 IS - 4 SN - 0025-9284, 0025-9284 KW - Borderline personality disorder KW - Clinics KW - Supervisors KW - Qualitative research KW - Transference KW - Psychotherapists KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1347816797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+the+Menninger+Clinic&rft.atitle=Adaptive+institutional+transference+in+the+treatment+of+individuals+with+borderline+personality+disorder&rft.au=Matarazzo%2C+Bridget+B&rft.aulast=Matarazzo&rft.aufirst=Bridget&rft.date=2012-10-01&rft.volume=76&rft.issue=4&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+the+Menninger+Clinic&rft.issn=00259284&rft_id=info:doi/10.1521%2Fbumc.2012.76.4.297 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BMCLA4 N1 - SubjectsTermNotLitGenreText - Psychotherapists; Transference; Borderline personality disorder; Supervisors; Clinics; Qualitative research DO - http://dx.doi.org/10.1521/bumc.2012.76.4.297 ER - TY - JOUR T1 - The Role of PTSD and Length of Shelter Stay in Battered Women's Severity of Reabuse after Leaving Shelter AN - 1322716132; 201302587 AB - Intimate partner violence (IPV) is associated with significant morbidity, including high rates of reabuse even after women have taken steps to achieve safety. This study evaluated the roles of posttraumatic stress disorder (PTSD) symptom severity and length of shelter stay in the severity of reabuse in 103 IPV victims over a six-month period after leaving a battered women's shelter. Results suggest that the length of shelter stay is inversely related to reabuse severity after leaving shelter. Additionally, more severe PTSD symptoms on shelter exit were associated with greater reabuse severity after leaving shelter. Furthermore, additional study findings support prior research suggesting that the emotional numbing symptoms of PTSD are a significant risk factor for reabuse among IPV victims after leaving shelter. Adapted from the source document. JF - Journal of Aggression, Maltreatment & Trauma AU - Perez, Sara AU - Johnson, Dawn M AU - Walter, Kristen H AU - Johnson, Nicole AD - Department of Psychology, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA sara.perez@va.gov Y1 - 2012/10// PY - 2012 DA - October 2012 SP - 776 EP - 791 PB - Taylor & Francis, Philadelphia PA VL - 21 IS - 7 SN - 1092-6771, 1092-6771 KW - battered women's shelters intimate partner violence PTSD revictimization KW - Emotionally Disturbed KW - Partner Abuse KW - Victims KW - Shelters KW - Battered Women KW - Females KW - Posttraumatic Stress Disorder KW - Morbidity KW - article KW - 6146: crime & corrections KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1322716132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aggression%2C+Maltreatment+%26+Trauma&rft.atitle=The+Role+of+PTSD+and+Length+of+Shelter+Stay+in+Battered+Women%27s+Severity+of+Reabuse+after+Leaving+Shelter&rft.au=Perez%2C+Sara%3BJohnson%2C+Dawn+M%3BWalter%2C+Kristen+H%3BJohnson%2C+Nicole&rft.aulast=Perez&rft.aufirst=Sara&rft.date=2012-10-01&rft.volume=21&rft.issue=7&rft.spage=776&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aggression%2C+Maltreatment+%26+Trauma&rft.issn=10926771&rft_id=info:doi/10.1080%2F10926771.2012.702712 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-04-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Shelters; Posttraumatic Stress Disorder; Victims; Battered Women; Partner Abuse; Females; Emotionally Disturbed; Morbidity DO - http://dx.doi.org/10.1080/10926771.2012.702712 ER - TY - JOUR T1 - Comparison of Distribution- and Anchor-Based Approaches to Infer Changes in Health-Related Quality of Life of Prostate Cancer Survivors AN - 1125284135; 201226546 AB - To determine the minimal important difference (MID) in generic and prostate-specific health-related quality of life (HRQoL) using distribution- and anchor-based methods. Prospective cohort study of 602 newly diagnosed prostate cancer patients recruited from an urban academic hospital and a Veterans Administration hospital. Participants completed generic (SF-36) and prostate-specific HRQoL surveys at baseline and at 3, 6, 12, and 24 months posttreatment. Anchor-based and distribution-based methods were used to develop MID estimates. We compared the proportion of participants returning to baseline based on MID estimates from the two methods. MID estimates derived from combining distribution- and anchor-based methods for the SF-36 subscales are physical function = 7, role physical = 14, role emotional = 12, vitality = 9, mental health = 6, social function = 9, bodily pain = 9, and general health = 8; and for the prostate-specific scales are urinary function = 8, bowel function = 7, sexual function = 8, urinary bother = 9, bowel bother = 8, and sexual bother = 11. Proportions of participants returning to baseline values corresponding to MID estimates from the two methods were comparable. This is the first study to assess the MID for generic and prostate-specific HRQoL using anchor-based and distribution-based methods. Although variation exists in the MID estimates derived from these two methods, the recovery patterns corresponding to these estimates were comparable. Adapted from the source document. JF - Health Services Research AU - Jayadevappa, Ravishankar AU - Malkowicz, Stanley Bruce AU - Wittink, Marsha AU - Wein, Alan J AU - Chhatre, Sumedha AD - Division of Urology, Department of Surgery, Perelman School of Medicine. University of Pennsylvania, Philadelphia Veterans Administration Medical Center, Perelman Center for Advanced Medicine Y1 - 2012/10// PY - 2012 DA - October 2012 SP - 1902 EP - 1925 PB - Blackwell Publishers, Oxford UK VL - 47 IS - 5 SN - 0017-9124, 0017-9124 KW - Newly diagnosed KW - Health status KW - Bowels KW - Prostatic cancer KW - Hospitals KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125284135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Comparison+of+Distribution-+and+Anchor-Based+Approaches+to+Infer+Changes+in+Health-Related+Quality+of+Life+of+Prostate+Cancer+Survivors&rft.au=Jayadevappa%2C+Ravishankar%3BMalkowicz%2C+Stanley+Bruce%3BWittink%2C+Marsha%3BWein%2C+Alan+J%3BChhatre%2C+Sumedha&rft.aulast=Jayadevappa&rft.aufirst=Ravishankar&rft.date=2012-10-01&rft.volume=47&rft.issue=5&rft.spage=1902&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2012.01395.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Quality of life; Health status; Hospitals; Prostatic cancer; Bowels; Newly diagnosed DO - http://dx.doi.org/10.1111/j.1475-6773.2012.01395.x ER - TY - JOUR T1 - Hearing-aid counseling: Comparison of single-session informational counseling with single-session performance-perceptual counseling AN - 1125271623; 201215400 AB - Objective: Hearing-aid counseling can improve outcome but programs are often too resource-intensive to be clinically practical. Here we examined the effectiveness of single-session informational counseling with single-session performance-perceptual counseling. Design: Two forms of counseling were compared: informational counseling (IC) and performance-perceptual counseling (PPC). IC focused on discussing communication strategies and tips for hearing-aid use. PPC addressed the discrepancy between measured and perceived ability to understand speech. Outcomes were measured eight-to-ten weeks post-counseling using quantitative and qualitative measures: Hearing handicap inventory, abbreviated profile of hearing aid benefit, psychosocial impact of assistive devices scale (PIADS), international outcome inventory for hearing aids, and a semi-structured exit interview. Study sample: Seventy-four hearing aid-users with symmetrical sensorineural hearing loss participated. Results: Scores on the hearing questionnaires showed no change following either form of counseling. Scores on the PIADS improved for participants as a whole, and the semi-structured interview revealed increased hearing-aid use, better understanding and acceptance of hearing loss, increased use of communication strategies, and improved ability to explain hearing difficulties to others. Conclusions: A single session of hearing-aid counseling can improve hearing-aid use and satisfaction. Open-ended interview and/or quality of life measures are more sensitive to these benefits than hearing questionnaires. Adapted from the source document JF - International Journal of Audiology AU - Saunders, Gabrielle H AU - Forsline, Anna AD - National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Portland, USA gabrielle.saunders@va.gov Y1 - 2012/10// PY - 2012 DA - October 2012 SP - 754 EP - 764 VL - 51 IS - 10 SN - 1499-2027, 1499-2027 KW - Hearing Therapy (31580) KW - Hearing Aids (31250) KW - article KW - 6811: special education; hearing therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125271623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=Hearing-aid+counseling%3A+Comparison+of+single-session+informational+counseling+with+single-session+performance-perceptual+counseling&rft.au=Saunders%2C+Gabrielle+H%3BForsline%2C+Anna&rft.aulast=Saunders&rft.aufirst=Gabrielle&rft.date=2012-10-01&rft.volume=51&rft.issue=10&rft.spage=754&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hearing Therapy (31580); Hearing Aids (31250) ER - TY - JOUR T1 - Imatinib mesylate (Gleevec) induced unilateral optic disc edema. AN - 1081436758; 22960614 AB - Imatinib mesylate (Gleevec) is a chemotherapy medication developed to treat chronic myelogenous leukemia as well as gastrointestinal stromal tumors (Savage, N Engl J Med 2002;346:683-93). Ocular side effects are commonly reported with the use of imatinib mesylate, such as periorbital edema and epiphora. More serious ocular side effects, such as optic disc edema, are rarely reported. This case is of a patient who presented with monocular painless loss of vision in the left eye from a previously documented 20/20 to 20/70 shortly after starting treatment with imatinib mesylate. Every aspect of the ocular presentation and clinical history were addressed to unveil the cause of the disc edema. After ruling out all other causes, the patient was later diagnosed with unilateral optic disc edema as a related side effect of the toxicity from imatinib mesylate. The properties of imatinib mesylate and the possible etiology of secondary optic disc edema are discussed. This study aims to highlight the importance of systemic medications review for possible etiology of ocular disease as well as the multidisciplinary approach to managing oncology patients with ocular side effects. JF - Optometry and vision science : official publication of the American Academy of Optometry AU - DeLuca, Crystal AU - Shenouda-Awad, Nancy AU - Haskes, Charles AU - Wrzesinski, Stephen AD - Nebraska-Western Iowa Healthcare System, Lincoln, Nebraska 68510, USA. crystal.deluca2@va.gov Y1 - 2012/10// PY - 2012 DA - October 2012 SP - e16 EP - e22 VL - 89 IS - 10 KW - Antineoplastic Agents KW - 0 KW - Benzamides KW - Piperazines KW - Pyrimidines KW - Imatinib Mesylate KW - 8A1O1M485B KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Index Medicus KW - Protein-Tyrosine Kinases -- antagonists & inhibitors KW - Diagnosis, Differential KW - Humans KW - Gastrointestinal Stromal Tumors -- drug therapy KW - Aged KW - Gastrointestinal Neoplasms -- drug therapy KW - Follow-Up Studies KW - Antineoplastic Agents -- therapeutic use KW - Male KW - Antineoplastic Agents -- adverse effects KW - Pyrimidines -- adverse effects KW - Papilledema -- chemically induced KW - Pyrimidines -- therapeutic use KW - Piperazines -- therapeutic use KW - Papilledema -- diagnosis KW - Optic Disk -- drug effects KW - Piperazines -- adverse effects KW - Optic Disk -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081436758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Optometry+and+vision+science+%3A+official+publication+of+the+American+Academy+of+Optometry&rft.atitle=Imatinib+mesylate+%28Gleevec%29+induced+unilateral+optic+disc+edema.&rft.au=DeLuca%2C+Crystal%3BShenouda-Awad%2C+Nancy%3BHaskes%2C+Charles%3BWrzesinski%2C+Stephen&rft.aulast=DeLuca&rft.aufirst=Crystal&rft.date=2012-10-01&rft.volume=89&rft.issue=10&rft.spage=e16&rft.isbn=&rft.btitle=&rft.title=Optometry+and+vision+science+%3A+official+publication+of+the+American+Academy+of+Optometry&rft.issn=1538-9235&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-03-14 N1 - Date created - 2012-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anticancer system created by acrolein and hydroxyl radical generated in enzymatic oxidation of spermine and other biochemical reactions. AN - 1039038150; 22874453 AB - A hypothesis suggesting the existence of a ubiquitous physiological anticancer system created by two highly reactive oxidative stress inducers with anticancer properties, acrolein and hydroxyl radical, is reported in this communication. Both components can originate separately or together in several biochemical interactions, among them, the enzymatic oxidation of the polyamine spermine, which appear to be their main source. The foundations of this hypothesis encompass our initial search for growth-inhibitors or anticancer compounds in biological material leading to the isolation of spermine, a polyamine that became highly cytotoxic through the generation of acrolein, when enzymatically oxidized. Findings complemented with pertinent literature data by other workers and observed anticancer activities by sources capable of producing acrolein and hydroxyl radical. This hypothesis obvious implication: spermine enzymatic oxidations or other biochemical interactions that would co-generate acrolein and hydroxyl radical, the anticancer system components, should be tried as treatments for any given cancer. The biochemical generation of acrolein observed was totally unexpected, since this aldehyde was known; as a very toxic and highly reactive xenobiotic chemical produced in the pyrolysis of fats and other organic material, found as an atmospheric pollutant, in tobacco smoke and car emissions, and mainly used as a pesticide or aquatic herbicide. Numerous studies on acrolein, considered after our work a biological product, as well, followed. In them, acrolein widespread presence, its effects on diverse cellular proteins, such as, growth factors, and its anticancer activities, were additionally reported. Regarding hydroxyl radical, the second component of the proposed anticancer system, and another cytotoxic product in normal cell metabolism, it co-generates with acrolein in several biochemical interactions, occurrences suggesting that these products might jointly fulfill some biological role. Furthermore, hydroxyl radical shares with phosphoramide mustard, anticancer activities and many similar effects against DNA, including the production of damages resulting in mutagenesis and carcinogenesis, facts that led us to consider this radical, a biological counterpart of phosphoramide mustard. A physiological system involving acrolein and hydroxyl radical, consequently, will be expected to produce effects similar to those from acrolein and phosphoramide mustard, the main anticancer metabolites from the widely used drug, cyclophosphamide. Copyright © 2012 Elsevier Ltd. All rights reserved. JF - Medical hypotheses AU - Alarcon, R A AD - E.N. Rogers Memorial Veterans Administration Medical Center, Bedford, MA 01730, USA. rogalar@gmail.com Y1 - 2012/10// PY - 2012 DA - October 2012 SP - 522 EP - 530 VL - 79 IS - 4 KW - Anticarcinogenic Agents KW - 0 KW - Antineoplastic Agents KW - Phosphoramide Mustards KW - phosphoramide mustard KW - 10159-53-2 KW - Spermine KW - 2FZ7Y3VOQX KW - Hydroxyl Radical KW - 3352-57-6 KW - Acrolein KW - 7864XYD3JJ KW - Index Medicus KW - Phosphoramide Mustards -- metabolism KW - Oxidation-Reduction KW - Neoplasms -- drug therapy KW - Animals KW - Hydroxyl Radical -- metabolism KW - Humans KW - Oxidative Stress KW - Antineoplastic Agents -- metabolism KW - Phosphoramide Mustards -- pharmacology KW - Neoplasms -- prevention & control KW - Models, Biological KW - Antineoplastic Agents -- pharmacology KW - Neoplasms -- metabolism KW - Acrolein -- metabolism KW - Anticarcinogenic Agents -- pharmacology KW - Anticarcinogenic Agents -- metabolism KW - Spermine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1039038150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+hypotheses&rft.atitle=Anticancer+system+created+by+acrolein+and+hydroxyl+radical+generated+in+enzymatic+oxidation+of+spermine+and+other+biochemical+reactions.&rft.au=Alarcon%2C+R+A&rft.aulast=Alarcon&rft.aufirst=R&rft.date=2012-10-01&rft.volume=79&rft.issue=4&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Medical+hypotheses&rft.issn=1532-2777&rft_id=info:doi/10.1016%2Fj.mehy.2012.07.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-07-08 N1 - Date created - 2012-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mehy.2012.07.010 ER - TY - JOUR T1 - Natural IgM Mediates Complement-Dependent Uptake of Francisella tularensis by Human Neutrophils via Complement Receptors 1 and 3 in Nonimmune Serum AN - 1551630022; 20355171 AB - A fundamental step in the life cycle of Francisella tularensis is bacterial entry into host cells. F. tularensis activates complement, and recent data suggest that the classical pathway is required for complement factor C3 deposition on the bacterial surface. Nevertheless, C3 deposition is inefficient and neither the specific serum components necessary for classical pathway activation by F. tularensis in nonimmune human serum nor the receptors that mediate infection of neutrophils have been defined. In this study, human neutrophil uptake of GFP-expressing F. tularensis strains live vaccine strain and Schu S4 was quantified with high efficiency by flow cytometry. Using depleted sera and purified complement components, we demonstrated first that C1q and C3 were essential for F. tularensis phagocytosis, whereas C5 was not. Second, we used purification and immunodepletion approaches to identify a critical role for natural IgM in this process, and then used a wbtA2 mutant to identify LPS O-Ag and capsule as prominent targets of these Abs on the bacterial surface. Finally, we demonstrate using receptor-blocking Abs that CR1 (CD35) and CR3 (CD11b/CD18) acted in concert for phagocytosis of opsonized F. tularensis by human neutrophils, whereas CR3 and CR4 (CD11c/CD18) mediated infection of human monocyte-derived macrophages. Altogether, our data provide fundamental insight into mechanisms of F. tularensis phagocytosis and support a model whereby natural IgM binds to surface capsular and O-Ag polysaccharides of F. tularensis and initiates the classical complement cascade via C1q to promote C3 opsonization of the bacterium and phagocytosis via CR3 and either CR1 or CR4 in a phagocyte-specific manner. JF - Journal of Immunology AU - Schwartz, Justin T AU - Barker, Jason H AU - Long, Matthew E AU - Kaufman, Justin AU - McCracken, Jenna AU - Allen, Lee-Ann H AD - Department of Microbiology, University of Iowa and Veterans Administration Medical Center, Iowa City, IA 52242 Y1 - 2012/09/15/ PY - 2012 DA - 2012 Sep 15 SP - 3064 EP - 3077 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 United States VL - 189 IS - 6 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Data processing KW - Classical pathway KW - Complement component C1q KW - Leukocytes (neutrophilic) KW - Life cycle KW - Francisella tularensis KW - Infection KW - Polysaccharides KW - CD18 antigen KW - CD11c antigen KW - Cell activation KW - Flow cytometry KW - CD11b antigen KW - Lipopolysaccharides KW - Complement component C3 KW - Vaccines KW - Monocytes KW - Purification KW - Phagocytosis KW - Complement receptors KW - Immunoglobulin M KW - Opsonization KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1551630022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Natural+IgM+Mediates+Complement-Dependent+Uptake+of+Francisella+tularensis+by+Human+Neutrophils+via+Complement+Receptors+1+and+3+in+Nonimmune+Serum&rft.au=Schwartz%2C+Justin+T%3BBarker%2C+Jason+H%3BLong%2C+Matthew+E%3BKaufman%2C+Justin%3BMcCracken%2C+Jenna%3BAllen%2C+Lee-Ann+H&rft.aulast=Schwartz&rft.aufirst=Justin&rft.date=2012-09-15&rft.volume=189&rft.issue=6&rft.spage=3064&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/10.4049%2Fjimmunol.1200816 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-08-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Macrophages; Data processing; Classical pathway; Complement component C1q; Leukocytes (neutrophilic); Life cycle; Polysaccharides; Infection; CD18 antigen; CD11c antigen; Cell activation; Flow cytometry; CD11b antigen; Lipopolysaccharides; Complement component C3; Purification; Monocytes; Vaccines; Phagocytosis; Complement receptors; Immunoglobulin M; Opsonization; Francisella tularensis DO - http://dx.doi.org/10.4049/jimmunol.1200816 ER - TY - JOUR T1 - Alcohol expectancies, alcohol use, and hostility as longitudinal predictors of alcohol-related aggression. AN - 1449098776; 201323878 AB - The direct and interactive effects of alcohol expectancies for aggression, dispositional hostility, and heavy alcohol consumption on alcohol-related physical aggression were examined across the first four years of marriage in a sample of 634 newlywed couples. For husbands, alcohol aggression expectancies predicted increases in alcohol-related aggression; across husbands and wives, however, aggression expectancies were not found to interact with hostility or alcohol consumption to predict physical aggression. Consistent with previous research, hostility and alcohol consumption interacted with each other to predict alcohol-related aggression. Specifically, for both husbands and wives high in dispositional hostility, heavy alcohol consumption was positively associated with the occurrence of alcohol-related aggression; for those low in dispositional hostility, however, there was no association between alcohol consumption and alcohol-related aggression. Findings are contrasted with previous longitudinal research on alcohol aggression expectancies and physical aggression in married couples. The article discusses the extent to which findings may vary depending on whether expectancies are assessed in relation to alcohol's effect on one's own behavior versus alcohol's effect on others' behavior. [Copyright The American Psychological Association.] JF - Psychology of Addictive Behaviors AU - Kachadourian, Lorig K AU - Homish, Gregory G AU - Quigley, Brian M AU - Leonard, Kenneth E Y1 - 2012/09// PY - 2012 DA - September 2012 SP - 414 EP - 422 PB - American Psychological Association, Washington DC VL - 26 IS - 3 SN - 0893-164X, 0893-164X KW - alcohol expectancies KW - alcohol use KW - couples KW - violence and aggression KW - hostility KW - Alcohol consumption KW - Alcohol related expectations KW - Hostility KW - Married couples KW - Aggression KW - Alcohol related KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1449098776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Addictive+Behaviors&rft.atitle=Alcohol+expectancies%2C+alcohol+use%2C+and+hostility+as+longitudinal+predictors+of+alcohol-related+aggression.&rft.au=Kachadourian%2C+Lorig+K%3BHomish%2C+Gregory+G%3BQuigley%2C+Brian+M%3BLeonard%2C+Kenneth+E&rft.aulast=Kachadourian&rft.aufirst=Lorig&rft.date=2012-09-01&rft.volume=26&rft.issue=3&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/10.1037%2Fa0025842 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PABEEI N1 - SubjectsTermNotLitGenreText - Aggression; Married couples; Hostility; Alcohol consumption; Alcohol related; Alcohol related expectations DO - http://dx.doi.org/10.1037/a0025842 ER - TY - JOUR T1 - Transdermal nicotine during cue reactivity in adult smokers with and without anxiety disorders. AN - 1449095778; 201324378 AB - Transdermal nicotine almost doubles tobacco cessation rates; however, little is known about what happens to smokers during the quit process when they are wearing the nicotine patch and are confronted with high-risk smoking triggers. This is particularly important for smokers with psychological disorders who disproportionately represent today's smokers and have more trouble quitting. Using a mixed between- and within-subjects design, smokers with anxiety disorders (n = 61) and smokers without any current Axis I disorders (n = 38) received transdermal nicotine (21 mg) or a placebo patch over two assessment days separated by 48 hr. Urge to smoke was evaluated during a 5-hr patch absorption period (reflecting general smoking deprivation) and during imaginal exposure to theoretically high-risk triggers containing smoking cues, anxiety cues, both, or neutral cues. No differences were observed between smokers with and without anxiety disorders. Significant Patch x Time and Patch x Cue Content interactions were found. Both patch conditions experienced an increase in urge during the deprivation period, but postabsorption urge was significantly higher in the placebo condition, suggesting that transdermal nicotine attenuated the degree to which urge to smoke increased over time. During the cue reactivity trials, when participants received the nicotine patch, they experienced significantly lower urge in response to both smoking-only and neutral cues, but not when anxiety cues were present (alone or in combination with smoking cues). These data suggest that transdermal nicotine alleviates urge only under certain circumstances and that adjunctive interventions are likely necessary to address smoking urges in response to spikes in distress among smokers trying to quit. [Copyright The American Psychological Association.] JF - Psychology of Addictive Behaviors AU - Morissette, Sandra B AU - Gulliver, Suzy Bird AU - Kamholz, Barbara W AU - Spiegel, David A AU - Tiffany, Stephen T AU - Barlow, David H AD - Sandra.Morissette@va.gov Y1 - 2012/09// PY - 2012 DA - September 2012 SP - 507 EP - 518 PB - American Psychological Association, Washington DC VL - 26 IS - 3 SN - 0893-164X, 0893-164X KW - anxiety disorders KW - cue reactivity KW - nicotine KW - smoking KW - high-risk smoking triggers KW - tobacco cessation KW - Craving KW - Smoking KW - Anxiety disorders KW - Cessation KW - Cues KW - Transdermal nicotine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1449095778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Addictive+Behaviors&rft.atitle=Transdermal+nicotine+during+cue+reactivity+in+adult+smokers+with+and+without+anxiety+disorders.&rft.au=Morissette%2C+Sandra+B%3BGulliver%2C+Suzy+Bird%3BKamholz%2C+Barbara+W%3BSpiegel%2C+David+A%3BTiffany%2C+Stephen+T%3BBarlow%2C+David+H&rft.aulast=Morissette&rft.aufirst=Sandra&rft.date=2012-09-01&rft.volume=26&rft.issue=3&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/10.1037%2Fa0028828 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PABEEI N1 - SubjectsTermNotLitGenreText - Smoking; Cues; Transdermal nicotine; Anxiety disorders; Cessation; Craving DO - http://dx.doi.org/10.1037/a0028828 ER - TY - JOUR T1 - Arterial spin labeling MRI study of age and gender effects on brain perfusion hemodynamics AN - 1434024326; 18539679 AB - Normal aging is associated with diminished brain perfusion measured as cerebral blood flow (CBF), but previously it is difficult to accurately measure various aspects of perfusion hemodynamics including: bolus arrival times and delays through small arterioles, expressed as arterial-arteriole transit time. To study hemodynamics in greater detail, volumetric arterial spin labeling MRI with variable postlabeling delays was used together with a distributed, dual-compartment tracer model. The main goal was to determine how CBF and other perfusion hemodynamics vary with aging. Twenty cognitive normal female and 15 male subjects (age: 23-84 years old) were studied at 4 T. Arterial spin labeling measurements were performed in the posterior cingulate cortex, precuneus, and whole brain gray matter. CBF declined with advancing age (P < 0.001). Separately from variations in bolus arrival times, arterial-arteriole transit time increased with advancing age (P < 0.01). Finally, women had overall higher CBF values (P < 0.01) and shorter arterial-arteriole transit time (P < 0.01) than men, regardless of age. The findings imply that CBF and blood transit times are compromised in aging, and these changes together with differences between genders should be taken into account when studying brain perfusion. Magn Reson Med, 2012. [copy 2011 Wiley Periodicals, Inc. JF - Magnetic Resonance in Medicine AU - Liu, Yinan AU - Zhu, Xiaoping AU - Feinberg, David AU - Guenther, Matthias AU - Gregori, Johannes AU - Weiner, Michael W AU - Schuff, Norbert AD - Northern California Institute for Research and Education, San Francisco, California, USA., yinan.liu@va.gov Y1 - 2012/09// PY - 2012 DA - Sep 2012 SP - 912 EP - 922 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 68 IS - 3 SN - 0740-3194, 0740-3194 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Aging KW - Cerebral blood flow KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1434024326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Arterial+spin+labeling+MRI+study+of+age+and+gender+effects+on+brain+perfusion+hemodynamics&rft.au=Liu%2C+Yinan%3BZhu%2C+Xiaoping%3BFeinberg%2C+David%3BGuenther%2C+Matthias%3BGregori%2C+Johannes%3BWeiner%2C+Michael+W%3BSchuff%2C+Norbert&rft.aulast=Liu&rft.aufirst=Yinan&rft.date=2012-09-01&rft.volume=68&rft.issue=3&rft.spage=912&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.23286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-09-01 N1 - Last updated - 2014-04-03 N1 - SubjectsTermNotLitGenreText - Cerebral blood flow DO - http://dx.doi.org/10.1002/mrm.23286 ER - TY - JOUR T1 - Reappraising the use of beta -lactams to treat tuberculosis AN - 1285091325; 17437674 AB - The emergence of multidrug-resistant and extensively drug-resistant tuberculosis calls for novel approaches to treatment. Recent studies have shown that BlaC, the beta -lactamase of Mycobacterium tuberculosis, is the major determinant of beta -lactam resistance. This review invites the reader to explore evidence in order to answer the questions: can beta -lactam and beta -lactamase inhibitors adequately treat M. tuberculosis infection and are they a viable option in the management of resistant tuberculosis today? JF - Expert Review of Anti-infective Therapy AU - Kurz, Sebastian G AU - Bonomo, Robert A AD - super(1)Division of Pulmonary, Critical Care and Sleep Medicine, University Hospitals Case Medical Center and Louis Stokes Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA., robert.bonomo@med.va.gov Y1 - 2012/09// PY - 2012 DA - Sep 2012 SP - 999 EP - 1006 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 10 IS - 9 SN - 1478-7210, 1478-7210 KW - Microbiology Abstracts B: Bacteriology KW - Drug resistance KW - Infection KW - Reviews KW - Tuberculosis KW - beta -Lactam antibiotics KW - beta -Lactamase KW - Mycobacterium tuberculosis KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1285091325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Review+of+Anti-infective+Therapy&rft.atitle=Reappraising+the+use+of+beta+-lactams+to+treat+tuberculosis&rft.au=Kurz%2C+Sebastian+G%3BBonomo%2C+Robert+A&rft.aulast=Kurz&rft.aufirst=Sebastian&rft.date=2012-09-01&rft.volume=10&rft.issue=9&rft.spage=999&rft.isbn=&rft.btitle=&rft.title=Expert+Review+of+Anti-infective+Therapy&rft.issn=14787210&rft_id=info:doi/10.1586%2Feri.12.96 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-01 N1 - Number of references - 55 N1 - Last updated - 2013-02-22 N1 - SubjectsTermNotLitGenreText - beta -Lactamase; Reviews; Drug resistance; beta -Lactam antibiotics; Tuberculosis; Infection; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1586/eri.12.96 ER - TY - JOUR T1 - The Relationship Between Body Weight, Frailty, and the Disablement Process AN - 1221434605; 201228155 AB - Objectives. To prospectively examine the relationship between body weight, frailty, and the disablement process. Method. Longitudinal data from the Health and Retirement Study (1998-2006) were used to examine the relationship between being underweight, overweight, or obese (compared with normal weight) and the onset and progression of functional limitations and disabilities in instrumental activities of daily living (IADL) and activities of daily living (ADL) among a nationally representative sample of community-dwelling older adults (aged 50 and older) with characteristics of frailty (n = 11,491). Nonlinear multilevel models additionally adjusted for demographic characteristics and intra-individual changes in body weight, socioeconomic status, health behaviors, and health conditions over the course of 8 years. Results. Compared with their nonfrail normal weight counterparts, prefrail obese respondents have a 16% (p < 0.001) reduction in the expected functional limitations rate and frail overweight and obese respondents have a 10% (p < 0.01) and 36% (p < 0.001) reduction in the expected functional limitations rate, respectively. In addition, frail obese respondents have a 27% (p < 0.05) reduction in the expected ADL disability rate. Discussion. This study's findings suggest that underweight, overweight, and obese status differentially affect the risk for functional limitations and disabilities in IADL and ADL. Among prefrail and frail adults, some excess body weight in later life may be beneficial, reducing the rate of functional limitations and disability. Adapted from the source document. JF - Journals of Gerontology Series B: Psychological Sciences and Social Sciences AU - Bowen, Mary Elizabeth AD - James A. Haley Veterans Hospital, HSR&D/RR&D Center of Excellence, 8900 Grand Oak Circle, Tampa, FL 33637-1022 mary.bowen3@va.gov Y1 - 2012/09// PY - 2012 DA - September 2012 SP - 618 EP - 626 PB - Gerontological Society of America, Washington DC VL - 67B IS - 5 SN - 1079-5014, 1079-5014 KW - Sarcopenia, Obesity, Disease KW - Obesity KW - Body weight KW - Frail KW - Underweight KW - Functional impairment KW - Activities of daily living KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221434605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journals+of+Gerontology+Series+B%3A+Psychological+Sciences+and+Social+Sciences&rft.atitle=The+Relationship+Between+Body+Weight%2C+Frailty%2C+and+the+Disablement+Process&rft.au=Bowen%2C+Mary+Elizabeth&rft.aulast=Bowen&rft.aufirst=Mary&rft.date=2012-09-01&rft.volume=67B&rft.issue=5&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Journals+of+Gerontology+Series+B%3A+Psychological+Sciences+and+Social+Sciences&rft.issn=10795014&rft_id=info:doi/10.1093%2Fgeronb%2Fgbs067 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JGBSF3 N1 - SubjectsTermNotLitGenreText - Obesity; Activities of daily living; Functional impairment; Body weight; Frail; Underweight DO - http://dx.doi.org/10.1093/geronb/gbs067 ER - TY - JOUR T1 - Irreversible sequela in an arterial venous fistula with steal syndrome: A case study AN - 1125285067; 201227312 AB - Arteriovenous fistulas may be susceptible to steal syndrome from a variety of conditions. Steal syndrome is defined as arterial insufficiency distal to the arteriovenous fistula. The causality of the insufficiency may include arterial disease proximal or distal to the fistula, markedly high blood flow volume after creation, or undetected collateral flow. Prior arterial disease may expose insufficient profusion to the distal extremity after fistula creation. High blood flow volume immediately after fistula creation may perhaps cause steal syndrome symptoms, but this often resolves with fistula maturation. Undetected collateral flow, or side branches, from target vessels receive increased blood volume after fistula creation and expand, thereby stealing blood flow from the hand. This particular condition can potentially cause ischemic changes distal to the fistula with potentially irreversible sequela if not recognized in a timely manner. A sixty- one year old male, sent with chest pain to the emergency room from his dialysis center, was found to have steal syndrome with an accompanying motor deficit. The diagnosis of steal syndrome is based on physical examination, patient history, and confirmation testing such as doppler ultrasound, digital pressures or arteriogram. A thorough preoperative workup and careful postoperative monitoring can minimize steal syndrome and prevent permanent impairment. [Copyright Elsevier B.V.] JF - Journal of Vascular Nursing AU - Raml, Nancy M AD - Department of Vascular Surgery, Zablocki VA Medical Center and Marquette University College of Nursing, Milwaukee, Wisconsin nancy.raml@va.gov Y1 - 2012/09// PY - 2012 DA - September 2012 SP - 94 EP - 97 PB - Elsevier Ltd, The Netherlands VL - 30 IS - 3 SN - 1062-0303, 1062-0303 KW - Blood KW - Medical examinations KW - Chest pain KW - Collaterals KW - Blood flow KW - Arterial diseases KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125285067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Vascular+Nursing&rft.atitle=Irreversible+sequela+in+an+arterial+venous+fistula+with+steal+syndrome%3A+A+case+study&rft.au=Raml%2C+Nancy+M&rft.aulast=Raml&rft.aufirst=Nancy&rft.date=2012-09-01&rft.volume=30&rft.issue=3&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Journal+of+Vascular+Nursing&rft.issn=10620303&rft_id=info:doi/10.1016%2Fj.jvn.2012.02.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Blood flow; Arterial diseases; Collaterals; Medical examinations; Chest pain; Blood DO - http://dx.doi.org/10.1016/j.jvn.2012.02.001 ER - TY - JOUR T1 - Neuropsychological outcomes of mild traumatic brain injury, post-traumatic stress disorder and depression in Iraq-deployed US Army soldiers AN - 1125285063; 201227772 AB - Background: Traumatic brain injury (TBI) is a concern of contemporary military deployments. Whether milder TBI leads to enduring impairment remains controversial. Aims: To determine the influence of deployment TBI, and post-traumatic stress disorder (PTSD) and depression symptoms on neuropsychological and functional outcomes. Method: A sample of 760 US Army soldiers were assessed pre- and post-deployment. Outcomes included neuropsychological performances and subjective functional impairment. Results: In total, 9% of the participants reported (predominantly mild) TBI with loss of consciousness between pre- and post-deployment. At post-deployment, 17.6% of individuals with TBI screened positive for PTSD and 31.3% screened positive for depression. Before and after adjustment for psychiatric symptoms, TBI was significantly associated only with functional impairment. Both PTSD and depression symptoms adjusted for TBI were significantly associated with several neuropsychological performance deficits and functional impairment. Conclusions: Milder TBI reported by deployed service members typically has limited lasting neuropsychological consequences; PTSD and depression are associated with more enduring cognitive compromise. Declaration of interest: J.J.V., K.B., S.P.P. and M.F. are US government employees. Adapted from the source document. JF - The British Journal of Psychiatry AU - Vasterling, Jennifer J AU - Brailey, Kevin AU - Proctor, Susan P AU - Kane, Robert AU - Heeren, Timothy AU - Franz, Molly AD - Boston Healthcare System, 150 S. Huntington Ave, Boston, MA 02130, USA jennifer.vasterling@va.gov Y1 - 2012/09// PY - 2012 DA - September 2012 SP - 186 EP - 192 PB - Royal College of Psychiatrists, London UK VL - 201 IS - 3 SN - 0007-1250, 0007-1250 KW - Armies KW - Symptoms KW - Depression KW - Posttraumatic stress disorder KW - Functional impairment KW - Traumatic brain injury KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125285063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Psychiatry&rft.atitle=Neuropsychological+outcomes+of+mild+traumatic+brain+injury%2C+post-traumatic+stress+disorder+and+depression+in+Iraq-deployed+US+Army+soldiers&rft.au=Vasterling%2C+Jennifer+J%3BBrailey%2C+Kevin%3BProctor%2C+Susan+P%3BKane%2C+Robert%3BHeeren%2C+Timothy%3BFranz%2C+Molly&rft.aulast=Vasterling&rft.aufirst=Jennifer&rft.date=2012-09-01&rft.volume=201&rft.issue=3&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Psychiatry&rft.issn=00071250&rft_id=info:doi/10.1192%2Fbjp.bp.111.096461 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BJPYAJ N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Depression; Functional impairment; Armies; Traumatic brain injury; Symptoms DO - http://dx.doi.org/10.1192/bjp.bp.111.096461 ER - TY - JOUR T1 - Differences in nutrition status by body mass index in patients with peripheral artery disease AN - 1125284653; 201227146 AB - Peripheral Arterial Disease (PAD) is most prevalent in the elderly and associated with increased cardio vascular disease (CVD) morbidity and mortality. Treatment focuses on improving functional capacity and reducing CVD risk factors. To date, little is understood about dietary habits and weight in this patient population. Nutritional and weight recommendations are based on heart health, and little is known about the unique needs of elderly PAD patients with multiple comorbidities. This prospective study compared 1) the dietary intake of nonobese PAD patients in comparison with those who were obese and; 2) dietary intake of those patients with the Estimated Average Requirement (EAR) based on age, gender and BMI. Nutritional intake was assessed with the Block 98 Food Frequency Questionnaire. Body mass index (BMI) was calculated in accordance with the National Heart, Lung, and Blood Institute (NHLBI) guidelines. The study population was divided into obese (BMI = 30) and nonobese (NO) groups. Comparisons between groups were performed using the Mann-Whitney U test for continuous variables and the Chi-square test for ordinal variables. All tests were two-tailed and P 30) individuals. Obese participants reported greater intake of foods containing cholesterol and trans-fatty acids and more frequent intake of B vitamins in comparison with the NO BMI group. Additionally, the nutrient intake of all participants by age, gender and BMI was lower than the EAR for magnesium, folate, and Vitamin E. These results suggest that the nutritional intake of PAD patients differs based on gender and BMI. Additionally, EAR was lower for specific nutrients than recommended. Further investigation is needed to examine the association between nutritional intake and nutrition-related deficits. [Copyright Elsevier B.V.] JF - Journal of Vascular Nursing AU - Oka, Roberta K AU - Alley, Hugh F AD - Department of Nursing, VA Palo Alto Health Care Systems, Palo Alto, California Roberta.oka@va.gov Y1 - 2012/09// PY - 2012 DA - September 2012 SP - 77 EP - 87 PB - Elsevier Ltd, The Netherlands VL - 30 IS - 3 SN - 1062-0303, 1062-0303 KW - Obesity KW - Food KW - Gender KW - Nutrients KW - Body Mass Index KW - Morbidity-Mortality KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125284653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Vascular+Nursing&rft.atitle=Differences+in+nutrition+status+by+body+mass+index+in+patients+with+peripheral+artery+disease&rft.au=Oka%2C+Roberta+K%3BAlley%2C+Hugh+F&rft.aulast=Oka&rft.aufirst=Roberta&rft.date=2012-09-01&rft.volume=30&rft.issue=3&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Journal+of+Vascular+Nursing&rft.issn=10620303&rft_id=info:doi/10.1016%2Fj.jvn.2012.04.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Body Mass Index; Gender; Obesity; Nutrients; Food; Morbidity-Mortality DO - http://dx.doi.org/10.1016/j.jvn.2012.04.003 ER - TY - JOUR T1 - Speech-in-noise measures: Variable versus fixed speech and noise levels AN - 1081897087; 201225381 AB - Objective: The purpose was to determine if speech-recognition performances were the same when the speech level was fixed and the noise level varied as when the noise level was fixed and the speech level varied. Design: A descriptive/quasi-experimental experiment was conducted with Lists 3 and 4 of the revised speech perception in noise (R-SPIN) test, which involves high predictability (HP) and low predictability (LP) words. The R-SPIN was modified into a multiple signal-to-noise paradigm (23- to -1-dB in 3-dB decrements) from which the 50% points were calculated with the Spearman-Karber equation. Study sample: Sixteen young listeners with normal hearing and 48 older listeners with pure-tone hearing losses participated. Results: The listeners with normal hearing performed better than the listeners with hearing loss on both the HP and LP conditions. For both groups of listeners, (1) performance on the HP sentences was better than on the LP sentences, and (2) the mean 50% points were 0.1 to 0.4 dB lower (better) on the speech-variable, babble-fixed condition than on the speech-fixed, babble-variable condition. Conclusions: For practical purposes the = 0.4-dB differences are not considered noteworthy as the differences are smaller than the decibel value of one word on the test (0.6 dB). Adapted from the source document. JF - International Journal of Audiology AU - Wilson, Richard H AU - McArdle, Rachel Y1 - 2012/09// PY - 2012 DA - September 2012 SP - 708 EP - 712 PB - Informa Healthcare, Taylor and Francis, London UK VL - 51 IS - 9 SN - 1499-2027, 1499-2027 KW - Auditory perception, hearing loss, speech perception, speech recognition in multitalker babble KW - Speech perception KW - Listeners KW - Noise KW - Hearing KW - Hearing impairment KW - Speech KW - Models KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081897087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=Speech-in-noise+measures%3A+Variable+versus+fixed+speech+and+noise+levels&rft.au=Wilson%2C+Richard+H%3BMcArdle%2C+Rachel&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2012-09-01&rft.volume=51&rft.issue=9&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/10.3109%2F14992027.2012.684407 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Listeners; Noise; Speech; Hearing impairment; Hearing; Speech perception; Models DO - http://dx.doi.org/10.3109/14992027.2012.684407 ER - TY - JOUR T1 - Genetic Association of GABA-A Receptor Alpha-2 and Mu Opioid Receptor with Cocaine Cue-Reactivity: Evidence for Inhibitory Synaptic Neurotransmission Involvement in Cocaine Dependence AN - 1081896972; 201225163 AB - Background: This pilot feasibility study examined the role of genetics in laboratory-induced cocaine craving. Methods: Thirty-four African American, cocaine-dependent male subjects underwent a baseline assessment, cue-exposure session, and genetic analysis. Subjects were classified as either cue-reactive or nonreactive. Results: Among single nucleotide polymorphism markers in 13 candidate genes examined for association with cocaine cue-reactivity, two were statistically significant: GABRA2 (coding for GABA-A receptor alpha-2 subunit; rs11503014, nominal p = .001) and OPRM1 (coding for mu opioid receptor; rs2236256, nominal p = .03). Conclusions: These pilot results suggest that cocaine craving shows variability among cocaine-dependent subjects, and that GABRA2 and OPRM1 polymorphisms have differential influences on cocaine cue-reactivity, warranting studies in future research. Adapted from the source document. JF - The American Journal on Addictions AU - Smelson, David AU - Yu, Lei AU - Buyske, Steven AU - Gonzalez, Gerardo AU - Tischfield, Jay AU - Deutsch, Curtis K AU - Ziedonis, Douglas AD - Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Ave., Worcester, MA 01655 david.smelson@va.gov Y1 - 2012/09// PY - 2012 DA - September 2012 SP - 411 EP - 415 PB - Wiley Publishing, Malden, MA 02148 VL - 21 IS - 5 SN - 1055-0496, 1055-0496 KW - Craving KW - Coding KW - Variability KW - Genes KW - Opioids KW - Cocaine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081896972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+on+Addictions&rft.atitle=Genetic+Association+of+GABA-A+Receptor+Alpha-2+and+Mu+Opioid+Receptor+with+Cocaine+Cue-Reactivity%3A+Evidence+for+Inhibitory+Synaptic+Neurotransmission+Involvement+in+Cocaine+Dependence&rft.au=Smelson%2C+David%3BYu%2C+Lei%3BBuyske%2C+Steven%3BGonzalez%2C+Gerardo%3BTischfield%2C+Jay%3BDeutsch%2C+Curtis+K%3BZiedonis%2C+Douglas&rft.aulast=Smelson&rft.aufirst=David&rft.date=2012-09-01&rft.volume=21&rft.issue=5&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+on+Addictions&rft.issn=10550496&rft_id=info:doi/10.1111%2Fj.1521-0391.2012.00253.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cocaine; Opioids; Craving; Coding; Genes; Variability DO - http://dx.doi.org/10.1111/j.1521-0391.2012.00253.x ER - TY - JOUR T1 - Accuracy of distortion-product otoacoustic emissions-based ototoxicity monitoring using various primary frequency step-sizes AN - 1081896652; 201224799 AB - Objective: A cisplatin ototoxicity monitoring protocol was recently proposed using distortion-product otoacoustic emissions (DPOAEs) measured in 1/48th octave steps over the highest obtainable quarter octave (Dille et al, 2010). This protocol can take up to 40 minutes to complete in both ears among seriously ill patients in a potentially noisy test environment. The goal of the current study was to contrast the diagnostic accuracy of ototoxicity monitoring protocols based on changes in DPOAE levels at wider, more rapidly tested, primary frequency step sizes. Design: Measure DPOAE levels in 1/48th octave steps over the highest half-octave of obtainable DPOAEs prior to treatment and at each ototoxicity monitoring session during the course of treatment with cisplatin. Study sample: Nineteen cancer patients being treated with cisplatin at the Portland Veterans Affairs Medical Center were observed over 56 monitoring appointments. Hearing thresholds in the sensitive region for ototoxicity (SRO) were measured concurrently with DPOAE levels. Results: DPOAE levels measured in 1/24th octave steps provided comparable accuracy, and half the testing time, to the 1/48th octave step protocol previously described. Conclusions: DPOAE level shifts measured in 1/24th octave steps may provide a basis for rapid ototoxicity monitoring among adult cancer patients treated with cisplatin. Adapted from the source document. JF - International Journal of Audiology AU - McMillan, Garnett P AU - Konrad-Martin, Dawn AU - Dille, Marilyn F AD - VA RR&D National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Portland, OR, USA garnett.mcmillan@va.gov Y1 - 2012/09// PY - 2012 DA - September 2012 SP - 689 EP - 696 PB - Informa Healthcare, Taylor and Francis, London UK VL - 51 IS - 9 SN - 1499-2027, 1499-2027 KW - Distortion-product otoacoustic emissions, ototoxicity monitoring, cisplatin, fine structure KW - Goals KW - Veterans KW - Appointments KW - Ears KW - Accuracy KW - Hearing KW - Otoacoustic emissions KW - Thresholds KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081896652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=Accuracy+of+distortion-product+otoacoustic+emissions-based+ototoxicity+monitoring+using+various+primary+frequency+step-sizes&rft.au=McMillan%2C+Garnett+P%3BKonrad-Martin%2C+Dawn%3BDille%2C+Marilyn+F&rft.aulast=McMillan&rft.aufirst=Garnett&rft.date=2012-09-01&rft.volume=51&rft.issue=9&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/10.3109%2F14992027.2012.688143 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Accuracy; Cancer; Hearing; Veterans; Appointments; Goals; Ears; Thresholds; Otoacoustic emissions DO - http://dx.doi.org/10.3109/14992027.2012.688143 ER - TY - JOUR T1 - A berry thought-provoking idea: the potential role of plant polyphenols in the treatment of age-related cognitive disorders. AN - 1038071889; 22475317 AB - Today, tens of millions of elderly individuals worldwide suffer from dementia. While the pathogenesis of dementia is complex and incompletely understood, it may be, at least to a certain extent, the consequence of systemic vascular pathology. The metabolic syndrome and its individual components induce a proinflammatory state that damages blood vessels. This condition of chronic inflammation may damage the vasculature of the brain or be directly neurotoxic. Associations have been established between the metabolic syndrome, its constituents and dementia. A relationship has also been observed between certain dietary factors, such as constituents of the 'Mediterranean diet', and the metabolic syndrome; similar associations have been noted between these dietary factors and dementia. Fruit juices and extracts are under investigation as treatments for cognitive impairment. Blueberry, strawberry, blackberry, grape and plum juices or extracts have been successfully tested in cognitively impaired rodents. Published trials of the benefits of grape and blueberry juice in the treatment of small numbers of cognitively impaired persons have recently appeared. The benefits of fruit products are thought to be a result of its polyphenol content. A grape polyphenol found in grapes, resveratrol, now being studied in humans, and one in grapes and blueberries, pterostilbene, have been found to improve cognition in rodents. In the design of future human trials, one ought to consider the poor bioavailability of these products, the possible need to initiate the experimental therapy long before the onset of symptoms, and currently limited knowledge about the appropriate form (e.g. juice, powder or individual polyphenol) of treatment. JF - The British journal of nutrition AU - Cherniack, E Paul AD - Division of Geriatrics and Gerontology, Geriatrics Institute, Geriatrics and Extended Care Service and Geriatric Research Education, and Clinical Center (GRECC) of the Miami Veterans Affairs Medical Center, University of Miami Miller School of Medicine, 1201 NW 16th Street, Miami, FL 33125, USA. evan.cherniack@va.gov Y1 - 2012/09// PY - 2012 DA - September 2012 SP - 794 EP - 800 VL - 108 IS - 5 KW - Polyphenols KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Cognition Disorders -- drug therapy KW - Aging -- psychology KW - Polyphenols -- therapeutic use KW - Fruit UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038071889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+nutrition&rft.atitle=A+berry+thought-provoking+idea%3A+the+potential+role+of+plant+polyphenols+in+the+treatment+of+age-related+cognitive+disorders.&rft.au=Cherniack%2C+E+Paul&rft.aulast=Cherniack&rft.aufirst=E&rft.date=2012-09-01&rft.volume=108&rft.issue=5&rft.spage=794&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+nutrition&rft.issn=1475-2662&rft_id=info:doi/10.1017%2FS0007114512000669 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-12-27 N1 - Date created - 2012-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1017/S0007114512000669 ER - TY - RPRT T1 - SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER (SFVAMC) LONG RANGE DEVELOPMENT PLAN, FORT MILEY, SAN FRANCISCO, CALIFORNIA. AN - 1282511876; 15476 AB - PURPOSE: The implementation of a long range development plan (LRDP) for the San Francisco Veterans Affairs Medical Center (SFVAMC) at Fort Miley in San Francisco, California is proposed. The existing SFVAMC Fort Miley campus is located at 4150 Clement Street in the northwestern portion of San Francisco, adjacent to the outer Richmond neighborhood, approximately two miles west of State Route 1 (also known as Park Presidio Bypass Drive). The SFVAMC serves a population of more than 179,000 veterans in Marin, Napa, Sonoma, Lake, Mendocino, Humboldt, San Francisco and San Mateo Counties. In fiscal year 2011, the medical center treated over 37,000 unique patients with over 326,000 outpatient visits and 5,600 inpatient stays. The existing Fort Miley campus facilities occupy approximately one million square feet and include a 124-bed tertiary-care hospital, primary and specialty care services, and a 120-bed community living center. SFVAMC has identified a need for retrofitting existing buildings to meet the most recent seismic safety requirements and for an additional 589,000 square feet of medical facility space to satisfy the needs of all San Francisco Bay Area and North Coast veterans over the next 20 years. Three alternatives are evaluated in this draft EIS. Under the Fort Miley campus buildout alternative (Alternative 1), 394,000 gross square feet (gsf) of space would be added along with seismic upgrades to various existing structures in one near-term phase (Phase 1) and one long-term phase (Phase 2). Phase 1 near-term project components would involve new development and/or retrofitting of patient care, research, administrative, hotel (overnight, shared lodging facility), and parking structures on the existing 29-acre campus through mid-2015. All construction staging would occur within previously disturbed areas and demolition would result in a maximum of 56,000 cubic feet of construction waste, at least 50 percent of which would be reused or recycled. Phase 2 project components would primarily involve new development and/or retrofitting of patient care, research, administrative, and ambulatory care structures on the campus through 2023. The Fort Miley campus plus Mission Bay campus alternative (Alternative 2) would involve a combination of new development and renovation of existing buildings within the existing SFVAMC campus, and relocation of some aspects of the medical center to an alternate site. This alternative retains all of the Phase 1 project components and many of the Phase 2 project components that are included in Alternative 1. Phase 2 long-term project components would primarily involve development of a medical, research, and support space at the existing campus as well as development of ambulatory care, research, and parking structures at a potential new SFVAMC Mission Bay campus. Under the No Action Alternative (Alternative 3), the LRDP would not be implemented. POSITIVE IMPACTS: Implementation would enhance the SFVAMC's function as a vital medical center and state-of-the-art medical facility to serve veterans well into the future. Expansion would provide appropriate space to conduct/manage research, clinical, administrative, and educational programs. NEGATIVE IMPACTS: Construction would adversely impact the Fort Miley Historic District and archaeological resources. Under Alternative 2, construction of the Mission Bay campus would generate emissions of carbon monoxide, toxic air contaminants and particulate matter. JF - EPA number: 120279, Draft EIS--542 pages, Appendices--6,645 pages, August 31, 2012 PY - 2012 KW - Land Use KW - Air Quality KW - Air Quality Assessments KW - Archaeological Sites KW - Buildings KW - Cultural Resources Assessments KW - Demolition KW - Historic Districts KW - Hospitals KW - Parking KW - Research Facilities KW - Section 106 Statements KW - Traffic Analyses KW - California UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1282511876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2012-08-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=SAN+FRANCISCO+VETERANS+AFFAIRS+MEDICAL+CENTER+%28SFVAMC%29+LONG+RANGE+DEVELOPMENT+PLAN%2C+FORT+MILEY%2C+SAN+FRANCISCO%2C+CALIFORNIA.&rft.title=SAN+FRANCISCO+VETERANS+AFFAIRS+MEDICAL+CENTER+%28SFVAMC%29+LONG+RANGE+DEVELOPMENT+PLAN%2C+FORT+MILEY%2C+SAN+FRANCISCO%2C+CALIFORNIA.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Veterans Affairs, Veterans Health Administration, San Francisco, California; VA N1 - Date revised - 2013-01-01 N1 - SuppNotes - Draft. Preparation date: August 31, 2012 N1 - Last updated - 2013-01-30 ER - TY - JOUR T1 - Is DSM-IV criterion A2 associated with PTSD diagnosis and symptom severity? AN - 1611641690; 20764896 AB - The diagnostic criteria for posttraumatic stress disorder (PTSD) have received significant scrutiny. Several studies have investigated the utility of Criterion A2, the subjective emotional response to a traumatic event. The American Psychiatric Association (APA) has proposed elimination of A2 from the PTSD diagnostic criteria for DSM-5; however, there is mixed support for this recommendation and few studies have examined A2 in samples at high risk for PTSD such as veterans. In the current study of 908 veterans who screened positive for a traumatic event, A2 was not significantly associated with having been told by a doctor that the veteran had PTSD. Those who endorsed A2, however, reported greater PTSD symptom severity in the 3 DSM-IV symptom clusters of reexperiencing (d = 0.45), avoidance (d = 0.61), and hyperarousal (d = 0.44), and A2 was significantly associated with PTSD symptom severity for all 3 clusters (R super(2) = .25, .25, and .27, respectively) even with trauma exposure in the model. Thus, although A2 may not be a necessary criterion for PTSD diagnosis, its association with PTSD symptom severity warrants further exploration of its utility. JF - Journal of Traumatic Stress AU - Osei-Bonsu, Princess E AU - Spiro, Avron AU - Schultz, Mark R AU - Ryabchenko, Karen A AU - Smith, Eric AU - Herz, Lawrence AU - Eisen, Susan V AD - VA Boston Healthcare System, Boston, Massachusetts, USA., susan.eisen@va.gov Y1 - 2012/08// PY - 2012 DA - Aug 2012 SP - 368 EP - 375 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 4 SN - 0894-9867, 0894-9867 KW - Risk Abstracts KW - Posttraumatic stress disorder KW - Psychology KW - Stress KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1611641690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Traumatic+Stress&rft.atitle=Is+DSM-IV+criterion+A2+associated+with+PTSD+diagnosis+and+symptom+severity%3F&rft.au=Osei-Bonsu%2C+Princess+E%3BSpiro%2C+Avron%3BSchultz%2C+Mark+R%3BRyabchenko%2C+Karen+A%3BSmith%2C+Eric%3BHerz%2C+Lawrence%3BEisen%2C+Susan+V&rft.aulast=Osei-Bonsu&rft.aufirst=Princess&rft.date=2012-08-01&rft.volume=25&rft.issue=4&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Journal+of+Traumatic+Stress&rft.issn=08949867&rft_id=info:doi/10.1002%2Fjts.21720 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-10-01 N1 - Last updated - 2014-10-30 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Psychology; Stress DO - http://dx.doi.org/10.1002/jts.21720 ER - TY - JOUR T1 - Using the patient safety indicators to detect potential safety events among US veterans with psychotic disorders: clinical and research implications AN - 1266174804; 2011-326378 AB - Objective Patients with psychotic disorders often experience poorer health outcomes, but whether they experience increased risks of medical errors/patient safety events is less clear. A single state-level US study found acute care inpatients with schizophrenia were at higher risk of incurring some of the Agency for Healthcare Research and Quality (AHRQ) patient safety indicators (PSIs). We examined a nationwide sample of US Veteran's Health Administration (VHA) acute care inpatients to determine the rates observed among patients with psychotic disorders for a larger set of PSIs. Design Retrospective cohort analysis using administrative data. Participants and Setting Veterans with (n = 50 328) and without (n = 1 812 897) psychotic disorders (schizophrenia/schizoaffective disorder and other psychoses) admitted for acute care to US VHA hospitals during fiscal years 2003-06. Methods and Main Outcome Measures PSI rates were calculated using AHRQ's PSI software. Results Patients with psychotic disorders had significantly higher rates of postoperative respiratory failure, postoperative wound dehiscence and decubitus ulcer than those without psychotic disorders, although postoperative respiratory failures rates were not significantly higher among patients specifically diagnosed with schizophrenia. Patients with psychotic disorders had significantly lower rates of accidental puncture/laceration, foreign body left in during procedure and failure to rescue. However, the odds of failure to rescue were not significantly lower among surgical patients (the current focus of this PSI). Conclusions Acute care inpatient veterans with psychotic disorders experienced higher rates of several PSIs, but lower rates of others. Whether lower rates of certain PSIs reflect better or worse care for this population is uncertain. Adapted from the source document. JF - International Journal for Quality in Health Care AU - Smith, Eric G AU - Zhao, Shibei AU - Rosen, Amy K AD - Center for Health Quality, Outcomes and Economic Research, ENRM VA Medical Center, 200 Springs Road, Bedford, MA 01730, USA eric.smith5@va.gov Y1 - 2012/08// PY - 2012 DA - August 2012 SP - 321 EP - 329 PB - Oxford University Press, UK VL - 24 IS - 4 SN - 1353-4505, 1353-4505 KW - Health conditions and policy - Medicine and health care KW - Health conditions and policy - Health and health policy KW - Military and defense policy - Military personnel and veterans KW - Health conditions and policy - Diseases and disorders KW - Health conditions and policy - Hospitals and other health care facilities KW - Business and service sector - Accounting KW - Population groups, population policy, and demographics - Demography and census KW - hospital care quality indicators patient outcomes (health status, quality of life, mortality) safety indicators pressure ulcers appropriateness, under-use and over-use mental health disorders psychosis respiratory failure KW - Schizophrenia KW - Veterans KW - United States KW - Population KW - Patients KW - Health policy KW - Medical service KW - Fiscal year KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266174804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+for+Quality+in+Health+Care&rft.atitle=Using+the+patient+safety+indicators+to+detect+potential+safety+events+among+US+veterans+with+psychotic+disorders%3A+clinical+and+research+implications&rft.au=Smith%2C+Eric+G%3BZhao%2C+Shibei%3BRosen%2C+Amy+K&rft.aulast=Smith&rft.aufirst=Eric&rft.date=2012-08-01&rft.volume=24&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=International+Journal+for+Quality+in+Health+Care&rft.issn=13534505&rft_id=info:doi/10.1093%2Fintqhc%2Fmzs026 LA - English DB - PAIS Index N1 - Date revised - 2013-01-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medical service; Health policy; Patients; United States; Veterans; Schizophrenia; Hospitals; Fiscal year; Population DO - http://dx.doi.org/10.1093/intqhc/mzs026 ER - TY - JOUR T1 - Integrative approaches to couple therapy: a clinical case illustration AN - 1125220394; 201242798 AB - Although meta-analyses affirm that various treatments for couple distress produce statistically and clinically significant outcomes, research findings also indicate that a large percentage of couples fail to benefit from treatment or subsequently deteriorate following current therapies. Based on these findings, we advocate potential advantages of integrative approaches to couple therapy. The clinical practice of integrative approaches to couple therapy requires conceptual and clinical decision-making skills transcending those of any one theoretical modality and emphasizes the selection, sequencing and pacing of diverse interventions in a coherent manner. Principles of an integrative approach are explicated in a clinical case illustration. Adapted from the source document. JF - Journal of Family Therapy AU - Abbott, Brian V AU - Snyder, Douglas K AD - Veterans Administration Medical Center. Mountain Home Y1 - 2012/08// PY - 2012 DA - August 2012 SP - 306 EP - 320 PB - Blackwell Publishers, Oxford UK VL - 34 IS - 3 SN - 0163-4445, 0163-4445 KW - Couples KW - Skills KW - Conjoint Therapy KW - Psychological Distress KW - Intervention KW - Decision Making KW - Treatment Methods KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125220394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Therapy&rft.atitle=Integrative+approaches+to+couple+therapy%3A+a+clinical+case+illustration&rft.au=Abbott%2C+Brian+V%3BSnyder%2C+Douglas+K&rft.aulast=Abbott&rft.aufirst=Brian&rft.date=2012-08-01&rft.volume=34&rft.issue=3&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Therapy&rft.issn=01634445&rft_id=info:doi/10.1111%2Fj.1467-6427.2012.00597.x LA - English DB - Sociological Abstracts N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JFTHDH N1 - SubjectsTermNotLitGenreText - Conjoint Therapy; Couples; Treatment Methods; Skills; Intervention; Decision Making; Psychological Distress DO - http://dx.doi.org/10.1111/j.1467-6427.2012.00597.x ER - TY - JOUR T1 - Virulence and Plasmid Transferability of KPC Klebsiella pneumoniae at the Veterans Affairs Healthcare System of New Jersey AN - 1069194264; 17126193 AB - Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae infections are associated with high mortality; however, little is known about the virulence determinants of KPC-producing K. pneumoniae. At the Veterans Affairs New Jersey Healthcare System (VA NJHCS), we investigated the virulence and plasmid transferability of 60 clinically unique KPC-containing K. pneumoniae isolates. All 60 isolates were negative for known virulence factors K1, K2, and K5 capsular antigens; rmpA; and the aerobactin gene by polymerase chain reaction. Isolates varied in their susceptibility to neutrophil phagocytosis, but were less resistant than the virulent serotype K1 isolate. Additionally, no deaths were seen on murine lethality studies. Conjugation results of this study showed that the bla sub(KPC) gene can be transferred into an Escherichia coli J-53 strain but not to E. coli JP-995. However, the stability is very limited as E. coli J-53 does not retain bla sub(KPC)-containing plasmids for any period of time. The lack of virulence factors in the set of KPC-producing K. pneumoniae studied suggests that morbidity and mortality may be due to detection issues or lack of effective antibiotics. JF - Microbial Drug Resistance AU - Siu, L K AU - Lin, J-C AU - Gomez, E AU - Eng, R AU - Chiang, T AD - Veterans Affairs New jersey Healthcare System (VA NJHCS), 385 Tremont Ave., 111-ID, East Orange, NJ 07018, USA, tom.chiang@va.gov Y1 - 2012/08// PY - 2012 DA - Aug 2012 SP - 380 EP - 384 VL - 18 IS - 4 SN - 1076-6294, 1076-6294 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Antibiotics KW - Conjugation KW - Drug resistance KW - Infection KW - Lethality KW - Leukocytes (neutrophilic) KW - Morbidity KW - Mortality KW - Phagocytosis KW - Plasmids KW - Polymerase chain reaction KW - Serotypes KW - aerobactin KW - carbapenemase KW - virulence factors KW - Escherichia coli KW - Klebsiella pneumoniae KW - A 01350:Microbial Resistance KW - G 07770:Bacteria KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1069194264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Drug+Resistance&rft.atitle=Virulence+and+Plasmid+Transferability+of+KPC+Klebsiella+pneumoniae+at+the+Veterans+Affairs+Healthcare+System+of+New+Jersey&rft.au=Siu%2C+L+K%3BLin%2C+J-C%3BGomez%2C+E%3BEng%2C+R%3BChiang%2C+T&rft.aulast=Siu&rft.aufirst=L&rft.date=2012-08-01&rft.volume=18&rft.issue=4&rft.spage=380&rft.isbn=&rft.btitle=&rft.title=Microbial+Drug+Resistance&rft.issn=10766294&rft_id=info:doi/10.1089%2Fmdr.2011.0241 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2013-02-08 N1 - SubjectsTermNotLitGenreText - Mortality; Conjugation; Serotypes; virulence factors; aerobactin; Drug resistance; Leukocytes (neutrophilic); Antibiotics; carbapenemase; Plasmids; Infection; Morbidity; Lethality; Polymerase chain reaction; Phagocytosis; Escherichia coli; Klebsiella pneumoniae DO - http://dx.doi.org/10.1089/mdr.2011.0241 ER - TY - JOUR T1 - New Anticancer Agents: Hormones Made within the Heart AN - 1399902898; 16930639 AB - The heart is a sophisticated endocrine gland synthesizing the atrial natriuretic peptide (ANP) prohormone which contains four peptide hormones, namely atrial natriuretic peptide, vessel dilator, kaliuretic peptide and long-acting natriuretic peptide, which decrease up to 97% of human pancreatic, breast, colon, prostate, kidney and ovarian carcinomas, as well as small-cell and squamous cell lung cancer cells within 24 hours in cell culture. In vivo these four cardiac hormones eliminate up to 80% of human pancreatic adenocarcinomas, up to two-thirds of human breast cancers, and up to 86% of human small-cell lung cancers in athymic mice. Their anticancer mechanism(s) target the Rat sarcoma bound guanosine triphosphate (RAS)-mitogen activated protein kinase kinase 1/2 (MEK1/2)-extracellular signal related kinase 1/2 (ERK1/2) kinase cascade in cancer cells. These four cardiac hormones inhibit up to 95% of the basal activity of Ras, 98% of the phosphorylation of MEK1/2 kinases and 96% of the activation of basal activity of ERK1/2 kinases. They also completely block the activity of mitogens such as the ability of epidermal growth factor to stimulate ERK and RAS. In addition to inhibiting these mitogen-activated protein kinases (MAPKs) they also inhibit MAPK9, i.e. c-Jun-N-terminal kinase 2. These multiple kinase inhibitors are cytotoxic and cause cell death of cancer cells but not of normal cells. JF - Anticancer Research AU - Vesely, D L AD - James A. Haley Veterans Hospital (151), 13000 Bruce B. Downs Blvd., Tampa, Florida 33612, USA, david.vesely@va.gov Y1 - 2012/07// PY - 2012 DA - Jul 2012 SP - 2515 EP - 2521 VL - 32 IS - 7 SN - 0250-7005, 0250-7005 KW - Biotechnology and Bioengineering Abstracts KW - Ras protein KW - Heart KW - MAP kinase KW - Atrial natriuretic peptide KW - Pancreas KW - Cell culture KW - Hormones KW - Extracellular signal-regulated kinase KW - Phosphorylation KW - Colon KW - Sarcoma KW - Kidney KW - Protein kinase KW - Mitogens KW - Breast cancer KW - Guanosine KW - Adenocarcinoma KW - Prostate KW - Lung cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1399902898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+Research&rft.atitle=New+Anticancer+Agents%3A+Hormones+Made+within+the+Heart&rft.au=Vesely%2C+D+L&rft.aulast=Vesely&rft.aufirst=D&rft.date=2012-07-01&rft.volume=32&rft.issue=7&rft.spage=2515&rft.isbn=&rft.btitle=&rft.title=Anticancer+Research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-07-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Heart; Ras protein; MAP kinase; Pancreas; Atrial natriuretic peptide; Cell culture; Hormones; Extracellular signal-regulated kinase; Colon; Phosphorylation; Kidney; Sarcoma; Breast cancer; Mitogens; Protein kinase; Guanosine; Adenocarcinoma; Prostate; Lung cancer ER - TY - JOUR T1 - Correlates of Specialty Substance Use Disorder Treatment Among Female Patients in the Veterans Health Administration AN - 1364705290; 201304345 AB - We examined patient- and facility-level correlates of specialty substance use disorder (SUD) outpatient treatment receipt (at least 1 visit) and engagement (visit count) for female Veterans Health Administration patients in 2008. Overall, 33% of 15,653 females with SUD received specialty SUD outpatient treatment. Treatment receipt and engagement were positively related to being age 31 to 55, having a psychiatric comorbidity, and receiving treatment at facilities providing women's services. Additional facility-level factors related to treatment receipt were treatment at a facility with comorbid psychiatric services and more licensed psychosocial treatment providers per patient. More prescribers per patient was associated with more treatment engagement. Adapted from the source document. JF - Journal of Social Work Practice in the Addictions AU - Oliva, Elizabeth M AU - Gregor, Amy AU - Rogers, Jerry AU - Dalton, Aaron AU - Harris, Alex H S AU - Trafton, Jodie A AD - Health Science Specialist, VA Palo Alto Health Care System, Program Evaluation and Resource Center, Menlo Park, California, USA elizabeth.oliva@va.gov Y1 - 2012/07// PY - 2012 DA - July 2012 SP - 282 EP - 301 PB - Taylor & Francis, Philadelphia PA VL - 12 IS - 3 SN - 1533-256X, 1533-256X KW - Outpatients KW - Veterans KW - Substance Abuse KW - Treatment Programs KW - Health KW - Patients KW - Females KW - Psychiatry KW - Comorbidity KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1364705290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+Work+Practice+in+the+Addictions&rft.atitle=Correlates+of+Specialty+Substance+Use+Disorder+Treatment+Among+Female+Patients+in+the+Veterans+Health+Administration&rft.au=Oliva%2C+Elizabeth+M%3BGregor%2C+Amy%3BRogers%2C+Jerry%3BDalton%2C+Aaron%3BHarris%2C+Alex+H+S%3BTrafton%2C+Jodie+A&rft.aulast=Oliva&rft.aufirst=Elizabeth&rft.date=2012-07-01&rft.volume=12&rft.issue=3&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+Work+Practice+in+the+Addictions&rft.issn=1533256X&rft_id=info:doi/10.1080%2F1533256X.2012.702620 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-06-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Females; Patients; Treatment Programs; Veterans; Psychiatry; Health; Outpatients; Substance Abuse; Comorbidity DO - http://dx.doi.org/10.1080/1533256X.2012.702620 ER - TY - JOUR T1 - Posttraumatic Stress Disorder and Intimate Partner Violence in a Women's Headache Center AN - 1347782578; 201321649 AB - Background: Posttraumatic stress disorder has been linked to women's ill health, including headaches. Intimate partner violence, which may result in posttraumatic stress disorder, is often reported by women with headaches. Prior studies of intimate partner violence and headache have estimated lifetime but not 12-month prevalence. The researchers in this study examined the relationship between headache and posttraumatic stress disorder in a novel population, and estimated 12-month and lifetime prevalence rates of intimate partner violence. Methods: Patients were recruited from a women's headache center (n = 92) during 2006-07 and completed the Migraine Disability Assessment measure of headache severity. Posttraumatic stress disorder was measured using a modified Breslau scale. Twelve-month and lifetime physical intimate partner violence were measured with the Partner Violence Screen and the STaT ("slapped, threatened and throw") measure. Multivariable regression determined factors independently associated with headache severity. Results: Among all participants, 28.3% screened positive for posttraumatic stress disorder; 9.8% and 36.9% of women endorsed recent and lifetime intimate partner violence. Posttraumatic stress disorder was strongly associated with headache severity (Beta = 34.12, p = 0.01). Patients reporting lifetime intimate partner violence exhibited a trend of nine additional days of disability due to headache over 90 days. Conclusions: Posttraumatic stress disorder and intimate partner violence occur among a sizable proportion of women referred for headache. The authors' findings reaffirm that clinicians treating women with headaches must be aware of the possibility of posttraumatic stress disorder and intimate partner violence in such patients. Adapted from the source document. JF - Women & Health AU - Gerber, Megan R AU - Fried, Lise E AU - Pineles, Suzanne L AU - Shipherd, Jillian C AU - Bernstein, Carolyn A AD - VA Boston Healthcare System/Women's Health, Boston University School of Medicine, Boston, Massachusetts, USA megan.gerber@va.gov Y1 - 2012/07// PY - 2012 DA - July 2012 SP - 454 EP - 471 PB - Taylor & Francis, Philadelphia PA VL - 52 IS - 5 SN - 0363-0242, 0363-0242 KW - Methodology (Data Collection) KW - Physically Handicapped KW - Partner Abuse KW - Health KW - Patients KW - Females KW - Posttraumatic Stress Disorder KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1347782578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women+%26+Health&rft.atitle=Posttraumatic+Stress+Disorder+and+Intimate+Partner+Violence+in+a+Women%27s+Headache+Center&rft.au=Gerber%2C+Megan+R%3BFried%2C+Lise+E%3BPineles%2C+Suzanne+L%3BShipherd%2C+Jillian+C%3BBernstein%2C+Carolyn+A&rft.aulast=Gerber&rft.aufirst=Megan&rft.date=2012-07-01&rft.volume=52&rft.issue=5&rft.spage=454&rft.isbn=&rft.btitle=&rft.title=Women+%26+Health&rft.issn=03630242&rft_id=info:doi/10.1080%2F03630242.2012.684088 LA - English DB - Sociological Abstracts N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - WOHEDI N1 - SubjectsTermNotLitGenreText - Partner Abuse; Posttraumatic Stress Disorder; Females; Patients; Physically Handicapped; Methodology (Data Collection); Health DO - http://dx.doi.org/10.1080/03630242.2012.684088 ER - TY - JOUR T1 - Practitioner Perspectives of Evidence-Based Practice AN - 1315599813; 201301833 AB - Social work practitioners decide when and how to use evidence in their practice. There remains, however, little evidence to date about social workers' perspectives about and implementation of evidence-based practice (EBP). This survey of a national sample of social workers adds to our knowledge about how social workers locate information, how they determine the usefulness of the information, what barriers exist for the use of an EBP process, and whether their workplaces are oriented toward EBP. Findings suggest that barriers may be more complex than previously reported, but that social workers find evidence, read the professional literature, and consult with peers and mentors, often despite poor workplace support. Suggestions for dissemination of information are made, and a model of evidence use in practice is proposed. Adapted from the source document. JF - Families in Society AU - Wharton, Tracy C AU - Bolland, Kathleen A AD - Veterans Administration GRECC, 2215 Fuller Road (11G), Ann Arbor, MI 48105 twharton@umich.edu Y1 - 2012/07// PY - 2012 DA - July 2012 SP - 157 EP - 164 PB - Alliance for Children and Families, Milwaukee WI VL - 93 IS - 3 SN - 1044-3894, 1044-3894 KW - Peers KW - Social Workers KW - Information Dissemination KW - Constraints KW - Evidence Based Practice KW - Knowledge KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1315599813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Families+in+Society&rft.atitle=Practitioner+Perspectives+of+Evidence-Based+Practice&rft.au=Wharton%2C+Tracy+C%3BBolland%2C+Kathleen+A&rft.aulast=Wharton&rft.aufirst=Tracy&rft.date=2012-07-01&rft.volume=93&rft.issue=3&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Families+in+Society&rft.issn=10443894&rft_id=info:doi/10.1606%2F1044-3894.4220 LA - English DB - Social Services Abstracts N1 - Date revised - 2014-02-21 N1 - Number of references - 19 N1 - Last updated - 2016-09-28 N1 - CODEN - FASOEN N1 - SubjectsTermNotLitGenreText - Social Workers; Evidence Based Practice; Constraints; Peers; Information Dissemination; Knowledge DO - http://dx.doi.org/10.1606/1044-3894.4220 ER - TY - JOUR T1 - Simulating Geriatric Home Safety Assessments in a Three-Dimensional Virtual World AN - 1266173217; 201300025 AB - Virtual worlds could offer inexpensive and safe three-dimensional environments in which medical trainees can learn to identify home safety hazards. Our aim was to evaluate the feasibility, usability, and acceptability of virtual worlds for geriatric home safety assessments and to correlate performance efficiency in hazard identification with spatial ability, self-efficacy, cognitive load, and presence. In this study, 30 medical trainees found the home safety simulation easy to use, and their self-efficacy was improved. Men performed better than women in hazard identification. Presence and spatial ability were correlated significantly with performance. Educators should consider spatial ability and gender differences when implementing virtual world training for geriatric home safety assessments. Adapted from the source document. JF - Gerontology & Geriatrics Education AU - Andrade, Allen D AU - Cifuentes, Pedro AU - Mintzer, Michael J AU - Roos, Bernard A AU - Anam, Ramanakumar AU - Ruiz, Jorge G AD - Laboratory of E-Learning and Multimedia Research (LEMUR), Geriatric Research, Education, and Clinical Center (GRECC), Bruce W. Carter Veterans Affairs Medical Center, (11 GRC) 1201 NW 16th Street, Miami, FL 33125, USA allen.andrade@va.gov Y1 - 2012/07// PY - 2012 DA - July 2012 SP - 233 EP - 252 PB - Taylor & Francis, Philadelphia PA VL - 33 IS - 3 SN - 0270-1960, 0270-1960 KW - computer simulation, patient safety, virtual worlds, geriatrics, home care, patient-centered medical home KW - Assessment KW - Hazards KW - Elderly people KW - Personal safety KW - Identification KW - Spatial ability KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266173217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gerontology+%26+Geriatrics+Education&rft.atitle=Simulating+Geriatric+Home+Safety+Assessments+in+a+Three-Dimensional+Virtual+World&rft.au=Andrade%2C+Allen+D%3BCifuentes%2C+Pedro%3BMintzer%2C+Michael+J%3BRoos%2C+Bernard+A%3BAnam%2C+Ramanakumar%3BRuiz%2C+Jorge+G&rft.aulast=Andrade&rft.aufirst=Allen&rft.date=2012-07-01&rft.volume=33&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Gerontology+%26+Geriatrics+Education&rft.issn=02701960&rft_id=info:doi/10.1080%2F02701960.2011.611553 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-01-01 N1 - Last updated - 2016-09-27 N1 - CODEN - GGEDD6 N1 - SubjectsTermNotLitGenreText - Personal safety; Elderly people; Spatial ability; Hazards; Assessment; Identification DO - http://dx.doi.org/10.1080/02701960.2011.611553 ER - TY - JOUR T1 - A Report Template for Molecular Genetic Tests Designed to Improve Communication Between the Clinician and Laboratory AN - 1113219223; 17220134 AB - Aim: Errors are most likely to occur during the pre- and postanalytic phases of the genetic testing process, which can contribute to underuse, overuse, and misuse of genetic tests. To mitigate these errors, we created a template for molecular genetic test reports that utilizes the combined features of synoptic reporting and narrative interpretation. Methods: A variation of the Delphi consensus process with an expert panel was used to create a draft report template, which was further informed by focus group discussions with primary care physicians. Results: There was agreement that molecular genetic test reports should present information in groupings that flow in a logical manner, and most participants preferred the following order of presentation: patient and physician information, test performed, test results and interpretation, guidance on next steps, and supplemental information. We define data elements for the report as "required," "optional," "possible," and "not necessary"; provide recommendations regarding the grouping of these data elements; and describe the ideal design of the report template, including the preferred order of the report sections, formatting of data, and length of the report. Discussion: With input from key stakeholders and building upon prior work, we created a template for molecular genetic test reports designed to improve clinical decision making at the point of care. The template design should lead to more effective communication between the laboratory and ordering clinician. Studies are needed to assess the usefulness and effectiveness of molecular genetic test reports generated using this template. JF - Genetic Testing and Molecular Biomarkers AU - Scheuner, M T AU - Hilborne, L AU - Brown, J AU - Lubin, I M AD - VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Building 500, Room 3218, Los Angeles, CA 90073, USA, maren.scheuner@va.gov Y1 - 2012/07// PY - 2012 DA - Jul 2012 SP - 761 EP - 769 VL - 16 IS - 7 SN - 1945-0265, 1945-0265 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Communication KW - Data processing KW - Decision making KW - Genetic screening KW - G 07880:Human Genetics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1113219223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetic+Testing+and+Molecular+Biomarkers&rft.atitle=A+Report+Template+for+Molecular+Genetic+Tests+Designed+to+Improve+Communication+Between+the+Clinician+and+Laboratory&rft.au=Scheuner%2C+M+T%3BHilborne%2C+L%3BBrown%2C+J%3BLubin%2C+I+M&rft.aulast=Scheuner&rft.aufirst=M&rft.date=2012-07-01&rft.volume=16&rft.issue=7&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Genetic+Testing+and+Molecular+Biomarkers&rft.issn=19450265&rft_id=info:doi/10.1089%2Fgtmb.2011.0328 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-11-20 N1 - SubjectsTermNotLitGenreText - Decision making; Data processing; Communication; Genetic screening DO - http://dx.doi.org/10.1089/gtmb.2011.0328 ER - TY - JOUR T1 - Pure hyperbolic discount curves predict "eyes open" self-control AN - 1081866868; 201235125 AB - The models of internal self-control that have recently been proposed by behavioral economists do not depict motivational interaction that occurs while temptation is present. Those models that include willpower at all either envision a faculty with a motivation ("strength") different from the motives that are weighed in the marketplace of choice, or rely on incompatible goals among diverse brain centers. Both assumptions are questionable, but these models' biggest problem is that they do not let resolutions withstand re-examination while being challenged by impulsive alternatives. The economists' models all attempt to make a single equilibrium preference predictable from a person's prior incentives. This was the original purpose of these models' hyperboloid ("Beta-d") delay discount functions, which have been widely justified by the assumption that a person's intertemporal inconsistency (impulsiveness) can be accounted for by the arousal of appetite for visceral rewards. Although arousal is clearly a factor in some cases of intertemporal inconsistency, it cannot be blamed for others, and furthermore does not necessarily imply hyperboloid discounting. The inadequacy of Beta-d functions is particularly evident in models of internal self-control. I have reviewed several of these models, and have argued for a return to pure hyperbolic discount function as originally proposed, the relatively high tails of which can motivate a recursive process of self-prediction and thereby the formation of self-enforcing intertemporal contracts. Such a process does not require a separately motivated faculty of will, or incompatible goals among brain centers; but it also does not permit the prediction of unique preferences from prior incentives. Adapted from the source document. JF - Theory and Decision AU - Ainslie, George AD - Veterans Affairs Medical Center, Coatesville, PA, USA George.Ainslie@va.gov Y1 - 2012/07// PY - 2012 DA - July 2012 SP - 3 EP - 34 PB - Springer, Dordrecht The Netherlands VL - 73 IS - 1 SN - 0040-5833, 0040-5833 KW - Motivation KW - Economists KW - Choices KW - Brain KW - Impulsiveness KW - Markets KW - Self Control KW - College Faculty KW - article KW - 0373: social psychology; cognitive/interpretive sociologies, symbolic interactionism, & ethnomethodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081866868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Theory+and+Decision&rft.atitle=Pure+hyperbolic+discount+curves+predict+%22eyes+open%22+self-control&rft.au=Ainslie%2C+George&rft.aulast=Ainslie&rft.aufirst=George&rft.date=2012-07-01&rft.volume=73&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Theory+and+Decision&rft.issn=00405833&rft_id=info:doi/10.1007%2Fs11238-011-9272-5 LA - English DB - Sociological Abstracts N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-28 N1 - CODEN - THDCBA N1 - SubjectsTermNotLitGenreText - Self Control; Economists; Brain; College Faculty; Markets; Motivation; Impulsiveness; Choices DO - http://dx.doi.org/10.1007/s11238-011-9272-5 ER - TY - JOUR T1 - A Prospective Examination of the Relationship Between Physical Activity and Dementia Risk in Later Life AN - 1034817776; 16930585 AB - Purpose. To examine the relationship between vigorous physical activity and dementia risk. Design. Prospective study design utilizing physical activity data from the Health and Retirement Study and cognitive outcome data from the Aging, Demographics, and Memory Study. Setting. Community-based. Subjects. Adults age 71 and over (N = 808) with 3 to 7 years of physical activity information prior to dementia/no dementia diagnosis. Measures. Physical activity was measured by participation in vigorous activities such as aerobics, sports, running, bicycling, and heavy housework three or more times per week (yes/no). Dementia diagnosis was based on an expert panel (e.g., neuropsychologists, neurologists, geropsychiatrists) who performed and reviewed a battery of neuropsychological tests. Analysis. Binary logistic regression models were used to account for demographic characteristics, genetic risk factors (one or two apolipoprotein E epsilon 4 alleles), health behaviors (e.g., smoking, drinking alcohol), health indicators (body mass index), and health conditions (e.g., diabetes, heart disease) in a sequential model-building process. Results. The relationship between vigorous physical activity and dementia risk remained robust across models. In the final model, older adults who were physically active were 21% (p less than or equal to .05) less likely than their counterparts to be diagnosed with dementia. Conclusion. Vigorous physical activity may reduce the risk for dementia independently of the factors examined here. This study's findings are important given that few preventative strategies for dementia have been explored beyond hormonal therapy and anti-inflammatory drugs. JF - American Journal of Health Promotion AU - Bowen, ME AD - Department of Veterans Affairs, James A. Haley Veterans Hospital, HSR&D/RR&D Research Center of Excellence, 8900 Grand Oak Circle, Tampa, FL 33637, USA, mary.bowen3@va.gov Y1 - 2012/07// PY - 2012 DA - Jul 2012 SP - 333 EP - 340 VL - 26 IS - 6 SN - 0890-1171, 0890-1171 KW - CSA Neurosciences Abstracts; Physical Education Index KW - Adults KW - Aging KW - Alcohol KW - Alzheimer's disease KW - Antiinflammatory agents KW - Apolipoprotein E4 KW - Bicycling KW - Body mass index KW - Cognitive ability KW - Data processing KW - Dementia disorders KW - Demographics KW - Demography KW - Diabetes mellitus KW - Ethanol KW - Evaluation KW - Exercise KW - Health KW - Heart diseases KW - Memory KW - Physical activity KW - Regression analysis KW - Reviews KW - Risk factors KW - Running KW - Smoking KW - Sports KW - N3 11001:Behavioral and Cognitive Neuroscience KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034817776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion&rft.atitle=A+Prospective+Examination+of+the+Relationship+Between+Physical+Activity+and+Dementia+Risk+in+Later+Life&rft.au=Bowen%2C+ME&rft.aulast=Bowen&rft.aufirst=ME&rft.date=2012-07-01&rft.volume=26&rft.issue=6&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion&rft.issn=08901171&rft_id=info:doi/10.4278%2Fajhp.110311-QUAN-115 LA - English DB - Physical Education Index N1 - Date revised - 2012-08-01 N1 - Last updated - 2013-02-08 N1 - SubjectsTermNotLitGenreText - Bicycling; Evaluation; Alcohol; Alzheimer's disease; Health; Adults; Exercise; Demographics; Heart diseases; Data processing; Running; Physical activity; Aging; Sports; Diabetes mellitus; Demography; Smoking; Memory; Apolipoprotein E4; Cognitive ability; Risk factors; Reviews; Dementia disorders; Regression analysis; Body mass index; Antiinflammatory agents; Ethanol DO - http://dx.doi.org/10.4278/ajhp.110311-QUAN-115 ER - TY - JOUR T1 - In Vitro Activity of TP-271 against Mycobacterium abscessus, Mycobacterium fortuitum, and Nocardia Species AN - 1028032700; 16873945 AB - The in vitro activities of TP-271, a novel fluorocycline antimicrobial, against 22 isolates of Mycobacterium abscessus, 22 isolates of Mycobacterium fortuitum, and 19 isolates of Nocardia spp. were studied by a microtiter broth dilution method. The MIC90s for M. abscessus, M. fortuitum, and Nocardia spp. were 0.5 mu g/ml, 0.03 mu g/ml, and 8 mu g/ml, respectively. TP-271 was significantly more active than the respective control drug in virtually all tests. JF - Antimicrobial Agents & Chemotherapy AU - Cynamon, Michael AU - Jureller, Jeff AU - Desai, Balaji AU - Ramachandran, Krithika AU - Sklaney, Mary AU - Grossman, Trudy H AD - VAMC, Syracuse, New York, USA, MichaelCynamon,michael.cynamon{at}med.va.gov. Y1 - 2012/07// PY - 2012 DA - Jul 2012 SP - 3986 EP - 3988 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 56 IS - 7 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Antimicrobial agents KW - Drugs KW - Mycobacterium abscessus KW - Mycobacterium fortuitum KW - Nocardia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028032700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vitro+Activity+of+TP-271+against+Mycobacterium+abscessus%2C+Mycobacterium+fortuitum%2C+and+Nocardia+Species&rft.au=Cynamon%2C+Michael%3BJureller%2C+Jeff%3BDesai%2C+Balaji%3BRamachandran%2C+Krithika%3BSklaney%2C+Mary%3BGrossman%2C+Trudy+H&rft.aulast=Cynamon&rft.aufirst=Michael&rft.date=2012-07-01&rft.volume=56&rft.issue=7&rft.spage=3986&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00743-12 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Number of references - 11 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Drugs; Antimicrobial agents; Mycobacterium abscessus; Mycobacterium fortuitum; Nocardia DO - http://dx.doi.org/10.1128/AAC.00743-12 ER - TY - JOUR T1 - Effect of (Neo)adjuvant zoledronic acid on disease-free and overall survival in clinical stage II/III breast cancer AN - 1028032984; 16859097 AB - Background: Despite neoadjuvant/adjuvant chemotherapy, women with resectable stage II/III breast cancer (BC) have high risk of recurrent disease. Recent data suggest that zoledronic acid (ZOL) therapy concurrent with adjuvant treatments may improve cancer-related outcomes in patients with BC. Methods: Disease-free survival (DFS; secondary end point) and overall survival (OS; tertiary end point) were evaluated in 119 women with stage II/III BC randomised to intravenous ZOL 4 mg every 3 weeks for 1 year or no ZOL (control) starting with the first chemotherapy cycle. Results: At 61.9 months' median follow-up, there was no significant difference in recurrence or survival between study arms. However, time to recurrence or death (DFS) was significantly different between subgroups defined by oestrogen receptor (ER) status (interaction P=0.010 for DFS and 0.025 for OS). Hazard ratios (HRs) for disease recurrence and death were significantly less among patients with ER-negative (ER super(-)) tumours who received ZOL vs no ZOL (DFS: HR=0.361, 95% confidence interval (CI) 0.148, 0.880; OS: HR=0.375, 95% CI 0.143, 0.985). Conclusion: ZOL administered with chemotherapy may improve DFS and OS in a subset of BC patients with ER super(-) tumours. This study was not powered to compare subgroups of patients; thus, these findings should be considered hypothesis generating. JF - British Journal of Cancer AU - Aft, R L AU - Naughton, M AU - Trinkaus, K AU - Weilbaecher, K AD - 1] Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA [2] Siteman Cancer Center, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA [3] John Cochran Veterans Administration Hospital, 915 North Grand Boulevard, St Louis, MO 63106, USA Y1 - 2012/06/26/ PY - 2012 DA - 2012 Jun 26 SP - 7 EP - 11 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 107 IS - 1 SN - 0007-0920, 0007-0920 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Breast cancer KW - Cancer KW - Chemotherapy KW - Mortality KW - Survival KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028032984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Effect+of+%28Neo%29adjuvant+zoledronic+acid+on+disease-free+and+overall+survival+in+clinical+stage+II%2FIII+breast+cancer&rft.au=Aft%2C+R+L%3BNaughton%2C+M%3BTrinkaus%2C+K%3BWeilbaecher%2C+K&rft.aulast=Aft&rft.aufirst=R&rft.date=2012-06-26&rft.volume=107&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fbjc.2012.210 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Mortality; Chemotherapy; Breast cancer; Survival; Tumors; Cancer DO - http://dx.doi.org/10.1038/bjc.2012.210 ER - TY - JOUR T1 - [ super(18)F] Uptake for PET/CT Scan Associated with Coronary Artery Disease AN - 1639990488; 17126029 AB - Since the feasibility of a fluoride positron emission tomography/computed tomography (PET/CT) scan for imaging atherosclerosis has not been well documented, a study was undertaken to assess fluoride uptake of vascular calcification in various major arteries, including coronary arteries. The imaging data and cardiovascular history of 61 patients who received whole-body sodium [ super(18)F]-fluoride PET/CT studies at our institution from 2009 to 2010 were retrospectively reviewed. [ super(18)F] uptake and calcification in major arteries, including coronary arteries, were analyzed by both visual assessment and standardized uptake value measurement. [ super(18)F] uptake in vascular walls was demonstrated in 361 sites of 54 (96%) patients, whereas calcification was observed in 317 sites of 49 (88%) patients. A significant correlation between the [ super(18)F] uptake and calcification was observed in most of the arterial walls, except in those of the abdominal aorta. [ super(18)F] uptake in coronary arteries was demonstrated in 28 (46%) patients and coronary calcifications were observed in 34 (56%) patients. There was a significant correlation between a history of cardiovascular events and the [ super(18)F] uptake in coronary arteries. The coronary fluoride uptake value in patients with cardiovascular events was significantly higher than in patients without cardiovascular events. It is concluded that sodium [ super(18)F]-fluoride PET/CT might be useful in the evaluation of the atherosclerotic process in major arteries, including coronary arteries. An increased [ super(18)F] uptake in coronary arteries may be associated with an increased cardiovascular risk. JF - Fluoride AU - Li, Y AU - Berenji, G R AU - Shaba, W F AU - Tafti, B AU - Yevdayev, E AU - Dadparvar, S AD - VA Greater Los Angeles Healthcare System, Nuclear Medicine Service (115), 11301 Wilshire Blvd. Los Anqeles, CA 90073, USA, Gholam.Berenjia@va.gov Y1 - 2012/06// PY - 2012 DA - Jun 2012 SP - 144 EP - 145 VL - 45 IS - 2 SN - 0015-4725, 0015-4725 KW - Aqualine Abstracts; Water Resources Abstracts KW - Institutions KW - Sodium KW - Evaluation KW - Risk KW - Assessments KW - History KW - Absorption KW - Diseases KW - Fluorides KW - SW 4050:Water law and institutions KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639990488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fluoride&rft.atitle=%5B+super%2818%29F%5D+Uptake+for+PET%2FCT+Scan+Associated+with+Coronary+Artery+Disease&rft.au=Li%2C+Y%3BBerenji%2C+G+R%3BShaba%2C+W+F%3BTafti%2C+B%3BYevdayev%2C+E%3BDadparvar%2C+S&rft.aulast=Li&rft.aufirst=Y&rft.date=2012-06-01&rft.volume=45&rft.issue=2&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Fluoride&rft.issn=00154725&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Evaluation; Sodium; Risk; Assessments; History; Absorption; Diseases; Institutions; Fluorides ER - TY - JOUR T1 - Expectancies regarding the interaction between smoking and substance use in alcohol-dependent smokers in early recovery AN - 1430188042; 201317228 AB - The purpose of this study was to investigate expectancies regarding the interaction between cigarette smoking and use of alcohol among alcohol-dependent smokers in early recovery, using the Nicotine and Other Substances Interaction Expectancies Questionnaire (NOSIE). Participants were 162 veterans, 97% male, with a mean age of 50 years, enrolled in a clinical trial aimed at determining the efficacy of an intensive smoking cessation intervention versus usual care. At baseline, participants were assessed on measures of smoking behavior, abstinence thoughts about alcohol and tobacco use, symptoms of depression, and smoking-substance use interaction expectancies. In addition, biologically verified abstinence from tobacco and alcohol was assessed at 26 weeks. Participants reported that they expected smoking to have less of an impact on substance use than substance use has on smoking (p < .001). Severity of depressive symptoms was significantly associated with the expectancy that smoking provides a way of coping with the urge to use other substances (p < .01). The expectation that smoking increases substance urges/use was predictive of prospectively measured and biologically verified abstinence from smoking at 26 weeks (p < .03). The results add to our knowledge of smoking-substance use interaction expectancies among alcohol-dependent smokers in early recovery and will inform the development of more effective counseling interventions for concurrent alcohol and tobacco use disorders. [Copyright The American Psychological Association.] JF - Psychology of Addictive Behaviors AU - Carmody, Timothy P AU - Delucchi, Kevin AU - Simon, Joel A AU - Duncan, Carol L AU - Solkowitz, Sharon N AU - Huggins, Joy AU - Lee, Sharon K AU - Hall, Sharon M AD - Mental Health Service, Veterans Affairs Medical Center, California, USA timothy.carmody@va.gov Y1 - 2012/06// PY - 2012 DA - June 2012 SP - 358 EP - 363 PB - American Psychological Association, Washington DC VL - 26 IS - 2 SN - 0893-164X, 0893-164X KW - alcohol dependence KW - expectancies KW - nicotine dependence KW - smoking cessation KW - tobacco use KW - early recovery KW - substance use KW - Alcohol consumption KW - Abstinence KW - Smoking KW - Depression KW - Recovery KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1430188042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Addictive+Behaviors&rft.atitle=Expectancies+regarding+the+interaction+between+smoking+and+substance+use+in+alcohol-dependent+smokers+in+early+recovery&rft.au=Carmody%2C+Timothy+P%3BDelucchi%2C+Kevin%3BSimon%2C+Joel+A%3BDuncan%2C+Carol+L%3BSolkowitz%2C+Sharon+N%3BHuggins%2C+Joy%3BLee%2C+Sharon+K%3BHall%2C+Sharon+M&rft.aulast=Carmody&rft.aufirst=Timothy&rft.date=2012-06-01&rft.volume=26&rft.issue=2&rft.spage=358&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/10.1037%2Fa0024424 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PABEEI N1 - SubjectsTermNotLitGenreText - Smoking; Substance abuse; Recovery; Abstinence; Alcohol consumption; Depression DO - http://dx.doi.org/10.1037/a0024424 ER - TY - JOUR T1 - Preventing Suicide through Improved Training in Suicide Risk Assessment and Care: An American Association of Suicidology Task Force Report Addressing Serious Gaps in U.S. Mental Health Training AN - 1347785308; 201303632 AB - There are twice as many suicides as homicides in the United States, and the suicide rate is rising. Suicides increased 12% between 1999 and 2009. Mental health professionals often treat suicidal patients, and suicide occurs even among patients who are seeking treatment or are currently in treatment. Despite these facts, training of most mental health professionals in the assessment and management of suicidal patients is surprisingly limited. The extant literature regarding the frequency with which mental health professionals encounter suicidal patients is reviewed, as is the prevalence of training in suicide risk assessment and management. Most importantly, six recommendations are made to address the longstanding insufficient training within the mental health professions regarding the assessment and management of suicidal patients. Adapted from the source document. JF - Suicide and Life-Threatening Behavior AU - Schmitz, William M AU - Allen, Michael H AU - Feldman, Barry N AU - Gutin, Nina J AU - Jahn, Danielle R AU - Kleespies, Phillip M AU - Quinnett, Paul AU - Simpson, Skip AD - 7850 Anselmo Lane, Baton Rouge, LA 70810 william.schmitzjr@va.gov Y1 - 2012/06// PY - 2012 DA - June 2012 SP - 292 EP - 304 PB - John Wiley & Sons, Inc. VL - 42 IS - 3 SN - 0363-0234, 0363-0234 KW - Homicide KW - Management KW - Training KW - United States of America KW - Suicide KW - Mental Health KW - Patients KW - Literature Reviews KW - Risk Assessment KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1347785308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Suicide+and+Life-Threatening+Behavior&rft.atitle=Preventing+Suicide+through+Improved+Training+in+Suicide+Risk+Assessment+and+Care%3A+An+American+Association+of+Suicidology+Task+Force+Report+Addressing+Serious+Gaps+in+U.S.+Mental+Health+Training&rft.au=Schmitz%2C+William+M%3BAllen%2C+Michael+H%3BFeldman%2C+Barry+N%3BGutin%2C+Nina+J%3BJahn%2C+Danielle+R%3BKleespies%2C+Phillip+M%3BQuinnett%2C+Paul%3BSimpson%2C+Skip&rft.aulast=Schmitz&rft.aufirst=William&rft.date=2012-06-01&rft.volume=42&rft.issue=3&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Suicide+and+Life-Threatening+Behavior&rft.issn=03630234&rft_id=info:doi/10.1111%2Fj.1943-278X.2012.00090.x LA - English DB - Social Services Abstracts N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SLBEDP N1 - SubjectsTermNotLitGenreText - Suicide; Literature Reviews; Patients; Training; Mental Health; Management; Risk Assessment; United States of America; Homicide DO - http://dx.doi.org/10.1111/j.1943-278X.2012.00090.x ER - TY - JOUR T1 - Visual attention to emotion in depression: Facilitation and withdrawal processes AN - 1283741462; 201301983 AB - Attentional biases for sadness are integral to cognitive theories of depression, but do not emerge under all conditions. Some researchers have argued that depression is associated with delayed withdrawal from, but not facilitated initial allocation of attention toward, sadness. We compared two types of withdrawal processes in clinically depressed and non-depressed individuals: (1) withdrawal requiring overt eye movements during visual search; and (2) covert disengagement of attention in a modified cueing paradigm. We also examined initial allocation of attention towards emotion on the visual search task, allowing comparison of withdrawal and facilitation processes. As predicted, we found no evidence of facilitated attention towards sadness in depressed individuals. However, we also found no evidence of depression-linked differences in withdrawal of attention from sadness on either task, offering no support for the theory that depression is associated with withdrawal rather than initial facilitation of attention. Adapted from the source document. JF - Cognition and Emotion AU - Wisco, Blair E AU - Treat, Teresa A AU - Hollingworth, Andrew AD - Department of Psychology, Yale University, New Haven, CT, USA Blair.wisco@va.gov Y1 - 2012/06// PY - 2012 DA - June 2012 SP - 602 EP - 614 PB - Psychology Press/Taylor & Francis, Basingstoke UK VL - 26 IS - 4 SN - 0269-9931, 0269-9931 KW - Depression Visual attention Attentional bias Cognitive bias KW - Emotions KW - Sadness KW - Depression KW - Cognitive theories KW - Visual searching KW - Facilitation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1283741462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cognition+and+Emotion&rft.atitle=Visual+attention+to+emotion+in+depression%3A+Facilitation+and+withdrawal+processes&rft.au=Wisco%2C+Blair+E%3BTreat%2C+Teresa+A%3BHollingworth%2C+Andrew&rft.aulast=Wisco&rft.aufirst=Blair&rft.date=2012-06-01&rft.volume=26&rft.issue=4&rft.spage=602&rft.isbn=&rft.btitle=&rft.title=Cognition+and+Emotion&rft.issn=02699931&rft_id=info:doi/10.1080%2F02699931.2011.595392 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - COEMEC N1 - SubjectsTermNotLitGenreText - Depression; Sadness; Facilitation; Emotions; Visual searching; Cognitive theories DO - http://dx.doi.org/10.1080/02699931.2011.595392 ER - TY - JOUR T1 - Adolescent substance use groups: antecedent and concurrent personality differences in a longitudinal study AN - 1074678407; 4341713 AB - This study attempted to extend Shedler and Block's () influential study, which found that adolescent drug experimenters had the healthiest personality functioning compared to abstainers and frequent users. Using a prospective design, we examined the relationship between antecedent and concurrent personality and age-18 substance use in a community sample of 1,298 twins (96% Caucasian, 49% male). Personality measures at ages 11 and 18 assessed positive emotionality (agentic and communal), negative emotionality, and constraint. Substance use groups - abstainers, experimenters, and problem users - were created at age 18. Age-18 substance use groups differed in age-11 and age-18 constraint such that problem users were lower than experimenters, who were lower than abstainers. Age-18 substance use groups did not differ in age-18 positive emotionality. However, abstainers were significantly lower than experimenters in communal positive emotionality, whereas female abstainers scored higher in agentic positive emotionality than female experimenters, who scored higher than female problem users. Experimenters were significantly lower in negative emotionality than problem users. Our findings are inconsistent with the notion that experimenters had the healthiest personality functioning and instead suggest different strengths and weaknesses for each group. Future studies should examine agentic and communal positive emotionality separately. Reprinted by permission of Blackwell Publishers JF - Journal of personality AU - Mcgue, Matt AU - Oliva, Elizabeth M AU - Keyes, Margaret AU - Iacono, William G AD - Veterans Administration Palo Alto Health Care System ; University of Minnesota ; University of Southern Denmark Y1 - 2012/06// PY - 2012 DA - Jun 2012 SP - 769 EP - 793 VL - 80 IS - 3 SN - 0022-3506, 0022-3506 KW - Sociology KW - Longitudinal studies KW - Groups KW - Emotions KW - Personality KW - Substance use KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1074678407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality&rft.atitle=Adolescent+substance+use+groups%3A+antecedent+and+concurrent+personality+differences+in+a+longitudinal+study&rft.au=Mcgue%2C+Matt%3BOliva%2C+Elizabeth+M%3BKeyes%2C+Margaret%3BIacono%2C+William+G&rft.aulast=Mcgue&rft.aufirst=Matt&rft.date=2012-06-01&rft.volume=80&rft.issue=3&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality&rft.issn=00223506&rft_id=info:doi/10.1111%2Fj.1467-6494.2011.00746.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 593; 12357; 5676; 9416 2153; 7541 7537 971; 4196 DO - http://dx.doi.org/10.1111/j.1467-6494.2011.00746.x ER - TY - JOUR T1 - Standardized Nursing Diagnoses in an Electronic Health Record: Nursing Survey Results AN - 1030903834; 201220313 AB - PURPOSE. A survey was conducted to obtain feedback from registered nurses as end-users of standardized nursing terminology for care planning in an electronic health record. Revisions to the care plan terminology were completed as part of an evidence-based project by nurses at one facility. METHODS. The survey was conducted pre-, post-, and 2-year post-implementation to obtain feedback from the acute care registered nurses (RNs). FINDINGS. Nurses reported a more positive agreement with the changes at 6 months compared with baseline, which generally was found to be sustained in the 2-year survey. Overall, the standardized terminology provided the nurses greater ease in their selection of nursing diagnoses and interventions in planning patient care, yet their reported satisfaction did not change. The survey identified several problematic areas related to nurses and care planning. Nurses reported less agreement with the statement about the care plans offering them the ability to determine the status of their patient's nursing care needs. They noted less agreement with statements of the care plan offering information on assessment of patient outcomes of nursing care. CONCLUSIONS. The patient plan of care in the electronic record is expected to offer nurses the ability to communicate the needs of the patient and assess outcomes of care. The survey findings indicate weaknesses warranting further exploration to identify changes needed to improve care planning documentation. Adapted from the source document. JF - International Journal of Nursing Knowledge AU - Estrada, Nicolette A AU - Dunn, Candice R AD - ACNS/Research (Nursing/118), VA Salt Lake City Health Care Systems, Salt Lake City, Utah nicolette.estrada@va.gov Y1 - 2012/06// PY - 2012 DA - June 2012 SP - 86 EP - 95 PB - Wiley-Blackwell, The Atrium, Southern Gate, Chichester, West Sussex PO19 8SQ, UK VL - 23 IS - 2 KW - Acute care KW - electronic health record KW - nursing KW - nursing diagnosis KW - standardized terminology KW - Care management KW - Terminology KW - Nursing KW - Nurses KW - Patient care KW - Care plans KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030903834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Nursing+Knowledge&rft.atitle=Standardized+Nursing+Diagnoses+in+an+Electronic+Health+Record%3A+Nursing+Survey+Results&rft.au=Estrada%2C+Nicolette+A%3BDunn%2C+Candice+R&rft.aulast=Estrada&rft.aufirst=Nicolette&rft.date=2012-06-01&rft.volume=23&rft.issue=2&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Nursing+Knowledge&rft.issn=&rft_id=info:doi/10.1111%2Fj.2047-3095.2011.01201.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nurses; Nursing; Patient care; Terminology; Care management; Care plans DO - http://dx.doi.org/10.1111/j.2047-3095.2011.01201.x ER - TY - JOUR T1 - A Case of Inaccurate Prognostication After the ARCTIC Protocol AN - 1030903546; 201220070 AB - Therapeutic hypothermia (ARCTIC, or Advanced Resuscitation Cooling Therapeutics and Intensive Care protocol) is a widely recommended intervention to improve mortality and neurologic outcomes after cardiac arrest. However, neurologic outcomes are difficult to predict soon after cardiac arrest in the setting of hypothermia, as illustrated by this case report. A 60-year-old man had witnessed cardiac arrest at home. He was defibrillated twice, with return of spontaneous circulation, and cooled to 33-Zero-Bar C for 24 hours. Neurologic exam on Day 6 revealed limited brainstem reflexes, and the intensive care unit team discussed with the patients family that his prognosis for neurologic recovery was poor. Palliative care was consulted to participate in a goals-of-care meeting. Just prior to the meeting on Day 7, the patient awoke. He fully recovered and walked out of the hospital on Day 18. Prior to induced hypothermia, indicators of poor outcome included lack of one or more brainstem reflexes (pupillary or corneal reflex), absence of motor response at 72 hours, myoclonus, status epilepticus, electroencephalogram with generalized suppression, and absent bilateral cortical N20 response to somatosensory-evoked potentials. However, several studies have found these indicators to be unreliable after hypothermia. This may be the result of sedatives, which can affect physical examination and electroencephalogram results, and delayed clearance. Because of the unreliability of prognostication tests within the first 72 hours of hypothermic protocols in the setting of sedation, it appears prudent in some cases to delay final prognosis discussions until at least six days postcardiac arrest and after neurologic evaluation is done with patients sedative-free. [Copyright U.S. Cancer Pain Relief Committee. Published by Elsevier Inc.] JF - Journal of Pain and Symptom Management AU - Chen, Christina J AU - Coyne, Patrick J AU - Lyckholm, Laurel J AU - Smith, Thomas J AD - Division of Hematology/Oncology and Palliative Care, Virginia Commonwealth University, MCV Box 980230, Richmond, VA 23298-0230, USA christina.chen3@va.gov Y1 - 2012/06// PY - 2012 DA - June 2012 SP - 1120 EP - 1125 PB - Elsevier, New York NY VL - 43 IS - 6 SN - 0885-3924, 0885-3924 KW - ARCTIC protocol, therapeutic hypothermia, prognosis, cardiac arrest, sedation KW - Hypothermia KW - Reflexes KW - Intensive care units KW - Prognosis KW - Intensive treatment KW - Myocardial infarction KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030903546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pain+and+Symptom+Management&rft.atitle=A+Case+of+Inaccurate+Prognostication+After+the+ARCTIC+Protocol&rft.au=Chen%2C+Christina+J%3BCoyne%2C+Patrick+J%3BLyckholm%2C+Laurel+J%3BSmith%2C+Thomas+J&rft.aulast=Chen&rft.aufirst=Christina&rft.date=2012-06-01&rft.volume=43&rft.issue=6&rft.spage=1120&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pain+and+Symptom+Management&rft.issn=08853924&rft_id=info:doi/10.1016%2Fj.jpainsymman.2011.06.024 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSPME2 N1 - SubjectsTermNotLitGenreText - Prognosis; Hypothermia; Myocardial infarction; Reflexes; Intensive care units; Intensive treatment DO - http://dx.doi.org/10.1016/j.jpainsymman.2011.06.024 ER - TY - JOUR T1 - Environmental Exposure and Health of Operation Enduring Freedom/Operation Iraqi Freedom Veterans AN - 1028036883; 16898530 AB - Objective: We characterized the prevalence of self-reported environmental exposures, concerns about exposures, and their relationships with somatic symptoms in Operation Enduring Freedom (Afghanistan) (OEF) and Operation Iraqi Freedom (Iraq) (OIF) veterans seeking treatment at a specialty Veterans Affairs (VA) clinic. Concerns about environmental exposures were expected to lead to more reporting of somatic symptom burden. Methods: We conducted a chart review of 469 OEF/OIF veterans seen at a VA tertiary care clinic. Results: OEF/OIF veterans reported a high level of environmental exposures and concerns about environmental exposures. Greater reported environmental exposures ( beta = 0.13) and environmental exposure concerns ( beta = 0.39) were associated with a greater somatic symptom burden. Exposure concerns accounted for some of the relationship of exposures on somatic symptom burden (confidence interval, 0.33-0.60). Conclusions: OEF/OIF veterans seeking treatment at a VA clinic reported a high prevalence of environmental exposures and exposure concerns. Both negatively impacted health outcomes. JF - Journal of Occupational and Environmental Medicine AU - McAndrew, L M AU - Teichman, R F AU - Osinubi, O Y AU - Jasien, J V AU - Quigley, K S AD - Department of Veterans Affairs, NJ War Related Illness and Injury Study Center, 385 Tremont Ave #129, East Orange, NJ 07018, USA, Lisa.McAndrew@va.gov Y1 - 2012/06// PY - 2012 DA - Jun 2012 SP - 665 EP - 669 VL - 54 IS - 6 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Reviews KW - Afghanistan KW - Iraq KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028036883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Environmental+Exposure+and+Health+of+Operation+Enduring+Freedom%2FOperation+Iraqi+Freedom+Veterans&rft.au=McAndrew%2C+L+M%3BTeichman%2C+R+F%3BOsinubi%2C+O+Y%3BJasien%2C+J+V%3BQuigley%2C+K+S&rft.aulast=McAndrew&rft.aufirst=L&rft.date=2012-06-01&rft.volume=54&rft.issue=6&rft.spage=665&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e318255ba1b LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Reviews; Afghanistan; Iraq DO - http://dx.doi.org/10.1097/JOM.0b013e318255ba1b ER - TY - JOUR T1 - The Role of the Advanced Practice Registered Nurse in Ensuring Evidence-Based Practice AN - 1023092480; 201216892 AB - The advanced practice registered nurse (APRN) is vital in role-modeling and ensuring evidence-based practice (EBP) engagement and application at the point of care. This article describes the formulation of national competencies for EBP, specific to the APRN level. The application of selected competencies is delineated and the creation of an APRN action plan to identify necessary EBP competencies is discussed. If EBP skills are lacking, the action plan is used for development of skills in the required areas. [Copyright Elsevier B.V.] JF - Nursing Clinics of North America AU - Moseley, Marthe J AD - Office of Nursing Service, Veterans Healthcare Administration and Rocky Mountain University of Health Professions Marthe.Moseley@va.gov Y1 - 2012/06// PY - 2012 DA - June 2012 SP - 269 EP - 281 PB - Elsevier Ltd, The Netherlands VL - 47 IS - 2 SN - 0029-6465, 0029-6465 KW - Advanced practice registered nurse (APRN) KW - Evidence-based practice (EBP) KW - Advanced practice role KW - Nursing KW - Advanced practice nurses KW - Work roles KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023092480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Clinics+of+North+America&rft.atitle=The+Role+of+the+Advanced+Practice+Registered+Nurse+in+Ensuring+Evidence-Based+Practice&rft.au=Moseley%2C+Marthe+J&rft.aulast=Moseley&rft.aufirst=Marthe&rft.date=2012-06-01&rft.volume=47&rft.issue=2&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Nursing+Clinics+of+North+America&rft.issn=00296465&rft_id=info:doi/10.1016%2Fj.cnur.2012.02.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Advanced practice nurses; Work roles DO - http://dx.doi.org/10.1016/j.cnur.2012.02.004 ER - TY - JOUR T1 - Clinical and phenotypic differences between classic and hypervirulent Klebsiella pneumonia: an emerging and under-recognized pathogenic variant AN - 1020849378; 16667029 AB - The purpose of this study was to increase awareness, gain insight into acquisition, and assess the virulence of the hypervirulent (hypermucoviscous) clinical variant (hvKP) that is entrenched in the Pacific Rim but emerging in Western countries. A case of community-acquired liver abscess with metastatic spread to the spleen is described. Comparative in vitro and in vivo virulence studies on this isolate (hvKP1) and four randomly chosen blood isolates of "classic" K. pneumonia strains (cKP1-4) were performed. Cases of hvKP infection are occurring in Western countries and are under-recognized. A hypermucoviscous phenotype is a surrogate laboratory marker for this variant. The propensity of hvKP strains for metastatic spread in non-compromised hosts is both a defining and unusual trait. The mode of acquisition in the described case was unclear but potential means are discussed. hvKP1 was more resistant to complement and neutrophil-mediated bactericidal activity and was more virulent in a rat subcutaneous abscess model than cKP1-4. Recognition of the hypermucoviscous phenotype, defined by a positive "string-test", will alert the microbiologist or clinician that the infecting strain may be a hvKP, which is hypervirulent compared to cKP. This will improve our understanding of the epidemiology and clinical spectrum of infection, which may be more extensive than appreciated. JF - European Journal of Clinical Microbiology & Infectious Diseases AU - Pomakova, D K AU - Hsiao, C-B AU - Beanan, J M AU - Olson, R AU - MacDonald, U AU - Keynan, Y AU - Russo, T A AD - Veterans Administration Western New York Healthcare System, Buffalo, NY, USA, trusso@acsu.buffalo.edu Y1 - 2012/06// PY - 2012 DA - Jun 2012 SP - 981 EP - 989 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 31 IS - 6 SN - 0934-9723, 0934-9723 KW - Microbiology Abstracts B: Bacteriology KW - Abscesses KW - Animal models KW - Bactericidal activity KW - Blood KW - Epidemiology KW - Infection KW - Liver KW - Metastases KW - Pneumonia KW - Spleen KW - Virulence KW - Klebsiella KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020849378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.atitle=Clinical+and+phenotypic+differences+between+classic+and+hypervirulent+Klebsiella+pneumonia%3A+an+emerging+and+under-recognized+pathogenic+variant&rft.au=Pomakova%2C+D+K%3BHsiao%2C+C-B%3BBeanan%2C+J+M%3BOlson%2C+R%3BMacDonald%2C+U%3BKeynan%2C+Y%3BRusso%2C+T+A&rft.aulast=Pomakova&rft.aufirst=D&rft.date=2012-06-01&rft.volume=31&rft.issue=6&rft.spage=981&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.issn=09349723&rft_id=info:doi/10.1007%2Fs10096-011-1396-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Metastases; Virulence; Blood; Epidemiology; Liver; Animal models; Spleen; Infection; Abscesses; Bactericidal activity; Pneumonia; Klebsiella DO - http://dx.doi.org/10.1007/s10096-011-1396-6 ER - TY - JOUR T1 - Determining population based mortality risk in the Department of Veterans Affairs AN - 1011214855; 16540845 AB - We develop a patient level hierarchical regression model using administrative claims data to assess mortality outcomes for a national VA population. This model, which complements more traditional process driven performance measures, includes demographic variables and disease specific measures of risk classified by Diagnostic Cost Groups (DCGs). Results indicate some ability to discriminate survivors and non-survivors with an area under the Receiver Operating Characteristic Curve (C-statistic) of .86. Observed to expected mortality ranges from .86 to 1.12 across predicted mortality deciles while Risk Standardized Mortality Rates (RSMRs) range from .76 to 1.29 across 145 VA hospitals. Further research is necessary to understand mortality variation which persists even after adjusting for case mix differences. Future work is also necessary to examine the role of personal behaviors on patient outcomes and the potential impact on population survival rates from changes in treatment policy and infrastructure investment. JF - Health Care Management Science AU - Stefos, Theodore AU - Lehner, Laura AU - Render, Marta AU - Moran, Eileen AU - Almenoff, Peter AD - Department of Veterans Affairs (VA), Office of Productivity, Efficiency and Staffing, Bedford, MA, USA, theodore.stefos@va.gov Y1 - 2012/06// PY - 2012 DA - Jun 2012 SP - 121 EP - 137 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 15 IS - 2 SN - 1386-9620, 1386-9620 KW - Risk Abstracts KW - Health care KW - Hospitals KW - Mortality KW - Standards KW - demography KW - infrastructure KW - survival KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011214855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Care+Management+Science&rft.atitle=Determining+population+based+mortality+risk+in+the+Department+of+Veterans+Affairs&rft.au=Stefos%2C+Theodore%3BLehner%2C+Laura%3BRender%2C+Marta%3BMoran%2C+Eileen%3BAlmenoff%2C+Peter&rft.aulast=Stefos&rft.aufirst=Theodore&rft.date=2012-06-01&rft.volume=15&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Health+Care+Management+Science&rft.issn=13869620&rft_id=info:doi/10.1007%2Fs10729-011-9189-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - demography; Mortality; Health care; Standards; survival; infrastructure; Hospitals DO - http://dx.doi.org/10.1007/s10729-011-9189-0 ER - TY - JOUR T1 - Model Choice and Sample Size in Item Response Theory Analysis of Aphasia Tests AN - 1125271199; 201215361 AB - Purpose: The purpose of this study was to identify the most appropriate item response theory (IRT) measurement model for aphasia tests requiring 2-choice responses and to determine whether small samples are adequate for estimating such models. Method: Pyramids and Palm Trees (Howard & Patterson, 1992) test data that had been collected from individuals with aphasia were analyzed, and the resulting item and person estimates were used to develop simulated test data for 3 sample size conditions. The simulated data were analyzed using a standard 1-parameter logistic (1-PL) model and 3 models that accounted for the influence of guessing: augmented 1-PL and 2-PL models and a 3-PL model. The model estimates obtained from the simulated data were compared to their known true values. Results: With small and medium sample sizes, an augmented 1-PL model was the most accurate at recovering the known item and person parameters; however, no model performed well at any sample size. Follow-up simulations confirmed that the large influence of guessing and the extreme easiness of the items contributed substantially to the poor estimation of item difficulty and person ability. Conclusion: Incorporating the assumption of guessing into IRT models improves parameter estimation accuracy, even for small samples. However, caution should be exercised in interpreting scores obtained from easy 2-choice tests, regardless of whether IRT modeling or percentage correct scoring is used. Adapted from the source document JF - American Journal of Speech-Language Pathology AU - Hula, William D AU - Fergadiotis, Gerasimos AU - Martin, Nadine AD - VA Pittsburgh Healthcare System and University of Pittsburgh william.hula@va.gov Y1 - 2012/05// PY - 2012 DA - May 2012 SP - s38 EP - s50 VL - 21 IS - 2 SN - 1058-0360, 1058-0360 KW - Aphasia (03400) KW - Diagnostic Tests (18550) KW - Psychoanalysis (69100) KW - article KW - 6414: language-pathological and normal; aphasia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125271199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Speech-Language+Pathology&rft.atitle=Model+Choice+and+Sample+Size+in+Item+Response+Theory+Analysis+of+Aphasia+Tests&rft.au=Hula%2C+William+D%3BFergadiotis%2C+Gerasimos%3BMartin%2C+Nadine&rft.aulast=Hula&rft.aufirst=William&rft.date=2012-05-01&rft.volume=21&rft.issue=2&rft.spage=s38&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Speech-Language+Pathology&rft.issn=10580360&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJSPFZ N1 - SubjectsTermNotLitGenreText - Psychoanalysis (69100); Diagnostic Tests (18550); Aphasia (03400) ER - TY - JOUR T1 - Association Between Alcohol Screening Scores and Alcohol- Related Risks Among Female Veterans Affairs Patients AN - 1093449876; 16670448 AB - Objective: Evidence-based brief interventions for primary care patients with at-risk drinking include personalized feedback on alcohol-related risks, yet little is known about associations between alcohol screening scores and outcomes among women. This study evaluated associations between scores on the three-item Alcohol Use Disorders Identification Test-consumption (AUDIT-C) questionnaire and self-reported alcohol-related risks and consequences among veteran women. Method: Female outpatients from an urban Veterans Affairs facility were mailed annual surveys (1998-2000) (response rates: 65% Years 1 and 2, 55% Year 3). Measures were obtained from each respondent's first completed survey and included a gender-specific AUDIT-C (0-12 points), self-reported alcohol-related consequences, problem drinking or other drug use, and health risks. The prevalence of each outcome across AUDIT-C score groups (0, 1-2, 3, 4, 5-7, 8-12) was estimated using logistic regression, adjusting for age, race, and marital status. Results: Among 2,670 respondents, 23.7% screened positive for alcohol misuse (AUDIT-C greater than or equal to 3). For three out of the five alcohol-related consequences (tolerance, blackouts, felt needed to cut down), adjusted prevalence increased at AUDIT-C scores of 3 or more. The remaining alcohol-related consequences (morning eye openers, family/friends worried) increased at scores of 4 or more, as did self-reported problem drinking or other drug use. Associations between health risks (two or more sexual partners, sexually transmitted diseases, injuries, domestic violence, hepatitis/cirrhosis) and AUDIT-C scores were less consistent, but prevalence generally increased at scores of 5 or more. Conclusions: Increasing scores on the AUDIT-C reflect increasing prevalence of self-reported alcohol-related risks and consequences among women. These results provide clinicians with gender-specific information on alcohol-related risks that could be incorporated into brief interventions. JF - Journal of Studies on Alcohol and Drugs AU - Chavez, L J AU - Williams, E C AU - Lapham, G AU - Bradley, KA AD - Health Services Research & Development, Veterans Affairs Puget Sound Health Care System, 1100 Olive Way, Suite 1400, Seattle, WA, 98101, USA, Laura.Chavez2@va.gov Y1 - 2012/05// PY - 2012 DA - May 2012 SP - 391 EP - 400 VL - 73 IS - 3 SN - 1937-1888, 1937-1888 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Alcohol KW - Domestic violence KW - Drug abuse KW - Gender KW - Health risks KW - Intervention KW - Marriage KW - Sexual behavior KW - Sexually transmitted diseases KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093449876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Association+Between+Alcohol+Screening+Scores+and+Alcohol-+Related+Risks+Among+Female+Veterans+Affairs+Patients&rft.au=Chavez%2C+L+J%3BWilliams%2C+E+C%3BLapham%2C+G%3BBradley%2C+KA&rft.aulast=Chavez&rft.aufirst=L&rft.date=2012-05-01&rft.volume=73&rft.issue=3&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Health risks; Alcohol; Gender; Intervention; Marriage; Domestic violence; Drug abuse; Sexual behavior; Sexually transmitted diseases ER - TY - JOUR T1 - A telehealth intervention for veterans on antiviral treatment for the hepatitis C virus. AN - 1081896944; 201225140 AB - The standard treatment for chronic hepatitis C (pegylated interferon and ribavirin) causes challenging physical and psychological side effects. The current pilot study evaluated the efficacy of a brief, telephone-based, cognitive-behavioral self-management intervention designed to address mood and quality of life within a sample of veterans on antiviral treatment for hepatitis C. Results from this pilot study support the feasibility of this telehealth intervention, showing that veterans were highly satisfied with the content of the intervention and compliant with the telephone calls. Findings further indicate that symptoms of depression and anxiety and mental health quality of life either remained stable or improved in those participants who received the brief telephone intervention, while those receiving usual care showed significant declines in mood and mental health quality of life. The findings from this study provide evidence that a brief, clinician-administered phone intervention may help individuals on antiviral therapy for hepatitis C to cope more effectively with the negative treatment side effects. [Copyright Elsevier B.V.] JF - Psychological Services AU - Silberbogen, Amy K AU - Ulloa, Erin AU - Mori, DeAnna L AU - Brown, Kirstin AD - VA Boston Healthcare System, Psychology Service, Boston, MA, US amy.silberbogen@va.gov Y1 - 2012/05// PY - 2012 DA - May 2012 SP - 163 EP - 173 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 9 IS - 2 SN - 1541-1559, 1541-1559 KW - health behaviors KW - hepatitis C KW - interferon KW - mental health KW - telehealth KW - veterans KW - antiviral treatment KW - intervention KW - Veterans KW - Telephone services KW - Pilot studies KW - Moods KW - Mental health KW - Hepatitis C KW - Side effects KW - Anxiety-Depression KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081896944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=A+telehealth+intervention+for+veterans+on+antiviral+treatment+for+the+hepatitis+C+virus.&rft.au=Silberbogen%2C+Amy+K%3BUlloa%2C+Erin%3BMori%2C+DeAnna+L%3BBrown%2C+Kirstin&rft.aulast=Silberbogen&rft.aufirst=Amy&rft.date=2012-05-01&rft.volume=9&rft.issue=2&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0026821 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hepatitis C; Veterans; Quality of life; Moods; Pilot studies; Anxiety-Depression; Telephone services; Mental health; Side effects DO - http://dx.doi.org/10.1037/a0026821 ER - TY - JOUR T1 - The use of Internet technology for psychoeducation and support with dementia caregivers. AN - 1081896243; 201224438 AB - A large randomized trial evaluated the benefits of online education, support, and self-care promotion for caregivers of persons with dementia. Anecdotal reports from participants indicated enjoyment of the materials, convenient access from home, and support from professionals and other caregivers. A substantial number of screened caregivers experienced obstacles of access, cost, and time regarding use of technology. Telephone options are being explored, and future caregiving generations are expected to have increased exposure and willingness to use computer technology, such as the program described here. [Copyright Elsevier B.V.] JF - Psychological Services AU - Hayden, Lisa J AU - Glynn, Shirley M AU - Hahn, Theodore J AU - Randall, Frychettya AU - Randolph, Eugenia AD - VA Greater Los Angeles Healthcare System at West Los Angeles, Los Angeles, CA, US lisa.hayden@va.gov Y1 - 2012/05// PY - 2012 DA - May 2012 SP - 215 EP - 218 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 9 IS - 2 SN - 1541-1559, 1541-1559 KW - Alzheimer's disease KW - caregiver support KW - dementia KW - internet technology KW - randomized trial KW - psychoeducation KW - Enjoyment KW - Computers KW - Selfcare KW - Promotion KW - Psychoeducational treatment KW - Dementia KW - Internet KW - Technology KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081896243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=The+use+of+Internet+technology+for+psychoeducation+and+support+with+dementia+caregivers.&rft.au=Hayden%2C+Lisa+J%3BGlynn%2C+Shirley+M%3BHahn%2C+Theodore+J%3BRandall%2C+Frychettya%3BRandolph%2C+Eugenia&rft.aulast=Hayden&rft.aufirst=Lisa&rft.date=2012-05-01&rft.volume=9&rft.issue=2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0027056 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Carers; Technology; Dementia; Internet; Psychoeducational treatment; Promotion; Enjoyment; Selfcare; Computers DO - http://dx.doi.org/10.1037/a0027056 ER - TY - JOUR T1 - Tele-pain management: Use of videoconferencing technology in the delivery of an integrated cognitive-behavioral and physical therapy group intervention. AN - 1081895746; 201224950 AB - Chronic pain has been recognized as a highly prevalent problem, and interdisciplinary treatments have been shown to be effective in the treatment of chronic pain. An integrated cognitive-behavioral and physical therapy group protocol has been developed and then implemented at remote sites using videoconferencing technology to provide pain management for veterans. The treatment model is summarized and recommendations are made for addressing challenges in implementing this type of treatment via videoconferencing. [Copyright Elsevier B.V.] JF - Psychological Services AU - Palyo, Sarah A AU - Schopmeyer, Kathryn A AU - McQuaid, John R AD - San Francisco VA Medical Center, San Francisco, CA, US sarah.palyo@va.gov Y1 - 2012/05// PY - 2012 DA - May 2012 SP - 200 EP - 202 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 9 IS - 2 SN - 1541-1559, 1541-1559 KW - chronic pain KW - depression KW - pain management KW - telehealth KW - tele-pain management KW - videoconferencing technology KW - integrated cognitive-behavioral & physical therapy group intervention KW - veterans KW - Veterans KW - Cognitive behaviour therapy KW - Chronic pain KW - Interdisciplinary approach KW - Videoconferencing KW - Physiotherapy KW - Treatment methods KW - Technology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081895746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Tele-pain+management%3A+Use+of+videoconferencing+technology+in+the+delivery+of+an+integrated+cognitive-behavioral+and+physical+therapy+group+intervention.&rft.au=Palyo%2C+Sarah+A%3BSchopmeyer%2C+Kathryn+A%3BMcQuaid%2C+John+R&rft.aulast=Palyo&rft.aufirst=Sarah&rft.date=2012-05-01&rft.volume=9&rft.issue=2&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0025987 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Chronic pain; Videoconferencing; Physiotherapy; Cognitive behaviour therapy; Technology; Treatment methods; Interdisciplinary approach; Veterans DO - http://dx.doi.org/10.1037/a0025987 ER - TY - JOUR T1 - The VA Maryland Health Care System's telemental health program. AN - 1081895183; 201224614 AB - The VA Maryland Health Care System introduced videoconferencing technology to provide psychiatry, evidenced-based psychotherapy, case management, and patient education at rural clinics where it was difficult to recruit providers. Telemental health services enable rural clinics to offer additional services, such as case management and patient education. Services have been expanded to urban outpatient clinics where a limited number of mental health clinic hours are available. This technology expands the availability of mental health providers and services, allowing patients to receive services from providers located at distant medical centers. [Copyright Elsevier B.V.] JF - Psychological Services AU - Koch, Edward F AD - Department of Veterans Affairs, Capitol Health Care Network, Linthicum Heights, MD, US Edward.Koch2@va.gov Y1 - 2012/05// PY - 2012 DA - May 2012 SP - 203 EP - 205 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 9 IS - 2 SN - 1541-1559, 1541-1559 KW - Department of Veterans Affairs KW - Maryland KW - VA KW - telehealth KW - telemental health KW - videoconferencing KW - Case management KW - Telepsychiatry KW - Recruits KW - Health care KW - Patient education KW - Mental health KW - Clinics KW - Rural communities KW - Psychiatry KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081895183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=The+VA+Maryland+Health+Care+System%27s+telemental+health+program.&rft.au=Koch%2C+Edward+F&rft.aulast=Koch&rft.aufirst=Edward&rft.date=2012-05-01&rft.volume=9&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0026144 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Clinics; Case management; Health care; Rural communities; Patient education; Mental health; Telepsychiatry; Psychiatry; Recruits DO - http://dx.doi.org/10.1037/a0026144 ER - TY - JOUR T1 - Difference between the default telecoil (t-coil) and programmed microphone frequency response in behind-the-ear (BTE) hearing aids. AN - 1024646266; pmid-22533979 AB - A telecoil (t-coil) is essential for hearing aid users when listening on the telephone because using the hearing aid microphone when communicating on the telephone can cause feedback due to telephone handset proximity to the hearing aid microphone. Clinicians may overlook the role of the t-coil due to a primary concern of matching the microphone frequency response to a valid prescriptive target. Little has been published to support the idea that the t-coil frequency response should match the microphone frequency response to provide "seamless" and perhaps optimal performance on the telephone. If the clinical goal were to match both frequency responses, it would be useful to know the relative differences, if any, that currently exist between these two transducers.The primary purpose of this study was to determine if statistically significant differences were present between the mean output (in dB SPL) of the programmed microphone program and the hearing aid manufacturer's default t-coil program as a function of discrete test frequencies. In addition, pilot data are presented on the feasibility of measuring the microphone and t-coil frequency response with real-ear measures using a digital speech-weighted noise.A repeated-measures design was utilized for a 2-cc coupler measurement condition. Independent variables were the transducer (microphone, t-coil) and 11 discrete test frequencies (15 discrete frequencies in the real-ear pilot condition).The study sample was comprised of behind-the-ear (BTE) hearing aids from one manufacturer. Fifty-two hearing aids were measured in a coupler condition, 39 of which were measured in the real-ear pilot condition. Hearing aids were previously programmed and verified using real-ear measures to the NAL-NL1 (National Acoustic Laboratories-Non-linear 1) prescriptive target by a licensed audiologist.Hearing aid output was measured with a Fonix 7000 hearing aid analyzer (Frye Electronics, Inc.) in a HA-2 2-cc coupler condition using a pure-tone sweep at an input level of 60 dB SPL with the hearing aid in the microphone program and 31.6 mA/M in the t-coil program. A digital speech weighted noise input signal presented at additional input levels was used in the real-ear pilot condition. A mixed-model repeated-measures analysis of variance (ANOVA) and the Tukey Honestly Significant Difference (HSD) post hoc test were utilized to determine if significant differences were present in performance across treatment levels.There was no significant difference between mean overall t-coil and microphone output averaged across 11 discrete frequencies (F(1,102) = 0, p < 0.98). A mixed-model repeated-measures ANOVA revealed a significant transducer by frequency interaction (F(10,102) = 13.0, p < 0.0001). Significant differences were present at 200 and 400 Hz where the mean t-coil output was less than the mean microphone output, and at 4000, 5000, and 6300 Hz where the mean t-coil output was greater than the mean microphone output.The mean t-coil output was significantly lower than the mean microphone output at 400 Hz, a frequency that lies within the typical telephone bandwidth of 300-3300 Hz. This difference may partially help to explain why some patients often complain the t-coil fails to provide sufficient loudness for telephone communication.American Academy of Audiology. JF - Journal of the American Academy of Audiology AU - Putterman, Daniel B AU - Valente, Michael AD - Program in Audiology and Communication Sciences, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. Daniel.Putterman@va.gov Y1 - 2012/05// PY - 2012 DA - May 2012 SP - 366 EP - 378 VL - 23 IS - 5 SN - 1050-0545, 1050-0545 KW - National Library of Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1024646266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Difference+between+the+default+telecoil+%28t-coil%29+and+programmed+microphone+frequency+response+in+behind-the-ear+%28BTE%29+hearing+aids.&rft.au=Putterman%2C+Daniel+B%3BValente%2C+Michael&rft.aulast=Putterman&rft.aufirst=Daniel&rft.date=2012-05-01&rft.volume=23&rft.issue=5&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2012-06-18 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Improving Patient Outcomes with Compression-Only CPR: Will Bystander CPR Rates Improve? AN - 1023092821; 201214028 AB - Offers an overview of compression-only CPR rates, with a focus on the significance and relevance of the problem, a review of epidemiological studies and research, and implications for health care and program development. [Copyright Elsevier B.V.] JF - Journal of Emergency Nursing AU - Drager, Kristin K Y1 - 2012/05// PY - 2012 DA - May 2012 SP - 234 EP - 238 PB - Elsevier Ltd, The Netherlands VL - 38 IS - 3 SN - 0099-1767, 0099-1767 KW - Clinical outcomes KW - Health care KW - Medical research KW - Bystanders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023092821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Emergency+Nursing&rft.atitle=Improving+Patient+Outcomes+with+Compression-Only+CPR%3A+Will+Bystander+CPR+Rates+Improve%3F&rft.au=Drager%2C+Kristin+K&rft.aulast=Drager&rft.aufirst=Kristin&rft.date=2012-05-01&rft.volume=38&rft.issue=3&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Journal+of+Emergency+Nursing&rft.issn=00991767&rft_id=info:doi/10.1016%2Fj.jen.2011.02.008 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Medical research; Clinical outcomes; Health care; Bystanders DO - http://dx.doi.org/10.1016/j.jen.2011.02.008 ER - TY - JOUR T1 - Weight Loss in Obese Older Adults Increases Serum Sclerostin and Impairs Hip Geometry But Both Are Prevented by Exercise Training AN - 1017982459; 16736999 AB - We reported that weight loss induces bone loss which is prevented by exercise training; however, the mechanism for this observation remains unclear. Sclerostin, an inhibitor of bone formation, has been found to increase in states of unloading and may mediate the changes in bone metabolism associated with weight loss and exercise. The objective of the study was to determine the effect of lifestyle intervention in obese older adults on sclerostin levels, and on hip geometry parameters. A total of 107 obese (body mass index [BMI] greater than or equal to 30 kg/m super(2)) older ( greater than or equal to 65 years) adults were randomly assigned to control, diet, exercise, and combined diet-exercise for 1 year. Sclerostin levels were measured by ELISA at baseline, 6 months, and 12 months, while hip geometry parameters were obtained from bone mineral density (BMD) images done by dual-energy X-ray absorptiometry using hip structure analysis at baseline and 12 months. Both the diet and diet-exercise groups had significant decreases in body weight (-9.6% and -9.4%, respectively), whereas weight was stable in the exercise and control groups. Sclerostin levels increased significantly and progressively in the diet group (6.6% plus or minus 1.7% and 10.5% plus or minus 1.9% at 6 and 12 months, respectively, all p < 0.05), whereas they were unchanged in the other groups; in particular, they were stable in the diet-exercise group (0.7% plus or minus 1.6% and 0.4% plus or minus 1.7% at 6 and 12 months, respectively, all p = 0.05). Hip geometry parameters showed significant decreases in cross-sectional area, cortical thickness, and BMD; and increases in buckling ratio at the narrow neck, intertrochanter, and femoral shaft. These negative changes on bone geometry were not observed in the diet-exercise group. Significant correlations between changes in sclerostin and changes in certain hip geometry parameters were also observed (p < 0.05). In conclusion, the increase in sclerostin levels with weight loss that was prevented by exercise may partly mediate the negative effects of weight loss on bone metabolism and the osteoprotective effect of exercise training. JF - Journal of Bone and Mineral Research AU - Armamento-Villareal, R AU - Sadler, C AU - Napoli, N AU - Shah, K AU - Chode, S AU - Sinacore AU - Qualls, C AU - Villareal, D T AD - New Mexico VA Health Care System, 1501 San Pedro SE, Albuquerque, NM, USA, dennis.villareal@va.gov Y1 - 2012/05// PY - 2012 DA - May 2012 SP - 1215 EP - 1221 VL - 27 IS - 5 SN - 0884-0431, 0884-0431 KW - Physical Education Index; Calcium & Calcified Tissue Abstracts KW - SOST protein KW - Bones KW - Dual energy X-ray absorptiometry KW - Adults KW - Femur KW - Unloading KW - Bone mineral density KW - Body weight KW - Osteogenesis KW - Diets KW - Obesity KW - Enzyme-linked immunosorbent assay KW - Weight control KW - Gerontology KW - Exercise (programs) KW - Hips KW - Physical training KW - Bone loss KW - Bone turnover KW - Exercise (effects) KW - Body mass index KW - Hip KW - T 2025:Bone and Bone Diseases KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017982459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bone+and+Mineral+Research&rft.atitle=Weight+Loss+in+Obese+Older+Adults+Increases+Serum+Sclerostin+and+Impairs+Hip+Geometry+But+Both+Are+Prevented+by+Exercise+Training&rft.au=Armamento-Villareal%2C+R%3BSadler%2C+C%3BNapoli%2C+N%3BShah%2C+K%3BChode%2C+S%3BSinacore%3BQualls%2C+C%3BVillareal%2C+D+T&rft.aulast=Armamento-Villareal&rft.aufirst=R&rft.date=2012-05-01&rft.volume=27&rft.issue=5&rft.spage=1215&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/10.1002%2Fjbmr.1560 LA - English DB - Physical Education Index N1 - Date revised - 2012-05-01 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - Obesity; Bone mineral density; Weight control; Bones; Gerontology; Adults; Exercise (effects); Exercise (programs); Hips; Diets; SOST protein; Enzyme-linked immunosorbent assay; Dual energy X-ray absorptiometry; Femur; Physical training; Unloading; Body weight; Bone loss; Bone turnover; Body mass index; Hip; Osteogenesis DO - http://dx.doi.org/10.1002/jbmr.1560 ER - TY - JOUR T1 - Health Care Reform and the Primary Care Workforce Bottleneck AN - 1762354614; PQ0002419920 AB - To establish and sustain the high-performing health care system envisioned in the Affordable Care Act (ACA), current provisions in the law to strengthen the primary care workforce must be funded, implemented, and tested. However, the United States is heading towards a severe primary care workforce bottleneck due to ballooning demand and vanishing supply. Demand will be fueled by the "silver tsunami" of 80 million Americans retiring over the next 20 years and the expanded insurance coverage for 32 million Americans in the ACA. The primary care workforce is declining because of decreased production and accelerated attrition. To mitigate the looming primary care bottleneck, even bolder policies will be needed to attract, train, and sustain a sufficient number of primary care professionals. General internists must continue their vital leadership in this effort. JF - Journal of General Internal Medicine AU - Schwartz, Mark D AD - Division of General Internal Medicine, New York University School of Medicine, VA New York Harbor Healthcare System, 423 E. 23rd Street, Suite 15N, New York, NY, 10010, USA, Mark.schwartz3@va.gov Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 469 EP - 472 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 27 IS - 4 SN - 0884-8734, 0884-8734 KW - Health & Safety Science Abstracts KW - USA KW - Health care KW - Attrition KW - Tsunamis KW - Insurance KW - Silver KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762354614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+General+Internal+Medicine&rft.atitle=Health+Care+Reform+and+the+Primary+Care+Workforce+Bottleneck&rft.au=Schwartz%2C+Mark+D&rft.aulast=Schwartz&rft.aufirst=Mark&rft.date=2012-04-01&rft.volume=27&rft.issue=4&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Journal+of+General+Internal+Medicine&rft.issn=08848734&rft_id=info:doi/10.1007%2Fs11606-011-1921-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Health care; Attrition; Tsunamis; Silver; Insurance; USA DO - http://dx.doi.org/10.1007/s11606-011-1921-4 ER - TY - JOUR T1 - Wearing the Garment of Widowhood: Variations in Time Since Spousal Loss Among Community-Dwelling Older Adults AN - 1567048836; 201437189 AB - We examine how the passage of time since spousal loss varies by social and demographic characteristics, using data from the University of Alabama at Birmingham Study of Aging. In multivariate analyses, African American race, female sex, lower income, and higher risk of social isolation had significant and independent associations with variation in time since spousal loss. African American women were at highest risk for long-term widowhood. Accurate characterizations of widowhood among community-dwelling older adults must consider variation in the length of time individuals are living as widowed persons and socioeconomic concomitants of long-term widowhood. Adapted from the source document. JF - Journal of Women & Aging AU - Williams, Beverly Rosa AU - Sawyer, Patricia AU - Allman, Richard M AD - The Birmingham/Atlanta VA Geriatric Research, Education and Clinical Center, Birmingham, AL Beverly.williams3@va.gov Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 126 EP - 139 PB - Taylor & Francis, Philadelphia PA VL - 24 IS - 2 SN - 0895-2841, 0895-2841 KW - Low Income Groups KW - Risk KW - Black Americans KW - Widowhood KW - Aging KW - Elderly KW - Females KW - Alabama KW - Sociodemographic Factors KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1567048836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Women+%26+Aging&rft.atitle=Wearing+the+Garment+of+Widowhood%3A+Variations+in+Time+Since+Spousal+Loss+Among+Community-Dwelling+Older+Adults&rft.au=Williams%2C+Beverly+Rosa%3BSawyer%2C+Patricia%3BAllman%2C+Richard+M&rft.aulast=Williams&rft.aufirst=Beverly&rft.date=2012-04-01&rft.volume=24&rft.issue=2&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Journal+of+Women+%26+Aging&rft.issn=08952841&rft_id=info:doi/10.1080%2F08952841.2012.639660 LA - English DB - Sociological Abstracts N1 - Date revised - 2014-10-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JWAGE5 N1 - SubjectsTermNotLitGenreText - Elderly; Widowhood; Black Americans; Females; Risk; Alabama; Sociodemographic Factors; Low Income Groups; Aging DO - http://dx.doi.org/10.1080/08952841.2012.639660 ER - TY - JOUR T1 - Coping trajectories in later life: A 20-year predictive study AN - 1541980235; 201415434 AB - Objectives and method: Information about aging-related change in coping is limited mainly to results of cross-sectional studies of age differences in coping, and no research has focused on predictors of aging-related change in coping behavior. To extend research in this area, we used longitudinal multilevel modeling to describe older adults' (n = 719; baseline M = 61 years) 20-year, intraindividual approach and avoidance coping trajectories, and to determine the influence of two sets of predictors (threat appraisal and stressor characteristics; gender and baseline personal and social resources) on level and rate of change in these trajectories. Results: Over the 20-year study interval, participants declined in the use of approach coping and most avoidance coping strategies, but there was significant variation in this trend. In simultaneous predictive models, female gender, more threat appraisal, stressor severity, social resources, and depressive symptoms, and fewer financial resources were independently associated with higher initial levels of coping responses. Having more social resources, and fewer financial resources, at baseline in late-middle-age predicted faster decline over time in approach coping. Having more baseline depressive symptoms, and fewer baseline financial resources, hastened decline in use of avoidance coping. Independent of other variables in these models, decline over time in approach coping and avoidance coping remained statistically significant. Conclusion: Overall decline in coping may be a normative pattern of coping change in later life. However, it also is modifiable by older adults' stressor appraisals, their stressors, and the personal and social resources they possess at entry to later life, in late-middle-age. Adapted from the source document. JF - Aging & Mental Health AU - Brennan, P L AU - Holland, J M AU - Schutte, K K AU - Moos, R H AD - Center for Health Care Evaluation, VA Palo Alto Health Care System, Menlo Park, CA, USA penny.brennan@va.gov Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 305 EP - 316 PB - Taylor & Francis, Abingdon UK VL - 16 IS - 3 SN - 1360-7863, 1360-7863 KW - Coping strategies KW - Depression KW - Gender KW - Social resources KW - Approach-Avoidance KW - Coping KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541980235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aging+%26+Mental+Health&rft.atitle=Coping+trajectories+in+later+life%3A+A+20-year+predictive+study&rft.au=Brennan%2C+P+L%3BHolland%2C+J+M%3BSchutte%2C+K+K%3BMoos%2C+R+H&rft.aulast=Brennan&rft.aufirst=P&rft.date=2012-04-01&rft.volume=16&rft.issue=3&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Aging+%26+Mental+Health&rft.issn=13607863&rft_id=info:doi/10.1080%2F13607863.2011.628975 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AMHTFD N1 - SubjectsTermNotLitGenreText - Coping; Approach-Avoidance; Social resources; Coping strategies; Gender; Depression DO - http://dx.doi.org/10.1080/13607863.2011.628975 ER - TY - JOUR T1 - Aging and mental health in the decade ahead: What psychologists need to know. AN - 1449098472; 201323890 AB - Until relatively recently, most psychologists have had limited professional involvement with older adults. With the baby boomers starting to turn 65 years old in 2011, sheer numbers of older adults will continue to increase. About 1 in 5 older adults has a mental disorder, such as dementia. Their needs for mental and behavioral health services are not now adequately met, and the decade ahead will require an approximate doubling of the current level of psychologists' time with older adults. Public policy in the coming decade will face tensions between cost containment and facilitation of integrated models of care. Most older adults who access mental health services do so in primary care settings, where interdisciplinary, collaborative models of care have been found to be quite effective. To meet the needs of the aging population, psychologists need to increase awareness of competencies for geropsychology practice and knowledge regarding dementia diagnosis, screening, and services. Opportunities for psychological practice are anticipated to grow in primary care, dementia and family caregiving services, decision-making-capacity evaluation, and end-of-life care. Aging is an aspect of diversity that can be integrated into psychology education across levels of training. Policy advocacy for geropsychology clinical services, education, and research remains critical. Psychologists have much to offer an aging society. [Copyright The American Psychological Association.] JF - American Psychologist AU - Karel, Michele J AU - Gatz, Margaret AU - Smyer, Michael A Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 184 EP - 198 PB - American Psychological Association, Washington DC VL - 67 IS - 3 SN - 0003-066X, 0003-066X KW - aging KW - geropsychology KW - mental health KW - policy KW - psychological practice KW - psychologists KW - Ageing KW - Elderly people KW - Advocacy KW - Psychologists KW - Primary health care KW - Dementia KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1449098472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Psychologist&rft.atitle=Aging+and+mental+health+in+the+decade+ahead%3A+What+psychologists+need+to+know.&rft.au=Karel%2C+Michele+J%3BGatz%2C+Margaret%3BSmyer%2C+Michael+A&rft.aulast=Karel&rft.aufirst=Michele&rft.date=2012-04-01&rft.volume=67&rft.issue=3&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=American+Psychologist&rft.issn=0003066X&rft_id=info:doi/10.1037%2Fa0025393 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Elderly people; Psychologists; Ageing; Dementia; Primary health care; Advocacy DO - http://dx.doi.org/10.1037/a0025393 ER - TY - JOUR T1 - Myths about male rape: A literature review. AN - 1373492931; 201314643 AB - Rape myths are one way in which sexual violence has been sustained and justified through history and modern times. However, there has been a dearth of scholarship about rape myths concerning male victims. This paper reviews the historical origins, development, and current manifestations of male rape myths prevalent in Western society. Specifically, we review male rape myths and their origins in the areas of medicine, law, media, the military, and incarcerated settings. The paper also delineates possible means for eradicating male rape myths at the individual, institutional, and societal levels. [Copyright The American Psychological Association.] JF - Psychology of Men & Masculinity AU - Turchik, Jessica A AU - Edwards, Katie M AD - National Center for PTSD at VA Palo Alto Health Care System, Department of Psychiatry and Behavioral Sciences at Stanford University Medical School, 795 Willow Road, Menlo Park, CA, US, 94025 jessica.turchik@va.gov Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 211 EP - 226 PB - American Psychological Association, Washington DC VL - 13 IS - 2 SN - 1524-9220, 1524-9220 KW - homosexuality KW - male rape KW - male victims KW - rape myths KW - sexual assault KW - Rape KW - Male rape KW - Myths KW - Victims KW - Historical perspectives KW - Sexual violence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1373492931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Men+%26+Masculinity&rft.atitle=Myths+about+male+rape%3A+A+literature+review.&rft.au=Turchik%2C+Jessica+A%3BEdwards%2C+Katie+M&rft.aulast=Turchik&rft.aufirst=Jessica&rft.date=2012-04-01&rft.volume=13&rft.issue=2&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Men+%26+Masculinity&rft.issn=15249220&rft_id=info:doi/10.1037%2Fa0023207 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Myths; Male rape; Rape; Victims; Sexual violence; Historical perspectives DO - http://dx.doi.org/10.1037/a0023207 ER - TY - JOUR T1 - Health Care Is For the Literate: Improving Health One Step at a Time AN - 1283634212; 201301426 AB - The health care system favors the literate. People who know how to gain access, complete myriad and formidable forms, and understand the information they are given have a much higher probability of receiving quality health care, following self-care regimens accurately, and maintaining their health. Improving health literacy has become a national imperative, as evidenced by recent major health policy changes and reforms. A cultural shift involving administrators, clinicians, and consumers is necessary for equalizing health care for all citizens and can be facilitated through the numerous informational and educational sites now available on the Internet. Adapted from the source document. JF - Journal of Consumer Health on the Internet AU - Schneider, Janet M AD - Department of Veterans Affairs, VA Library Network, Lakeland, Virginia, USA janet.schneider@va.gov Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 263 EP - 275 PB - Taylor & Francis, Philadelphia PA VL - 16 IS - 2 SN - 1539-8285, 1539-8285 KW - Health literacy KW - Health education KW - Patients KW - Trends KW - article KW - 10.13: INFORMATION COMMUNICATION - SCIENCE, TECHNOLOGY, MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1283634212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consumer+Health+on+the+Internet&rft.atitle=Health+Care+Is+For+the+Literate%3A+Improving+Health+One+Step+at+a+Time&rft.au=Schneider%2C+Janet+M&rft.aulast=Schneider&rft.aufirst=Janet&rft.date=2012-04-01&rft.volume=16&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consumer+Health+on+the+Internet&rft.issn=15398285&rft_id=info:doi/10.1080%2F15398285.2012.674001 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2013-02-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Health education; Patients; Trends DO - http://dx.doi.org/10.1080/15398285.2012.674001 ER - TY - JOUR T1 - Health Care Workforce Development in Rural America: When Geriatrics Expertise Is 100 Miles Away AN - 1266145537; 201300319 AB - The Geriatric Scholar Program (GSP) is a Department of Veterans Affairs' (VA) workforce development program to infuse geriatrics competencies in primary care. This multimodal educational program is targeted to primary care providers and ancillary staff who work in VA's rural clinics. GSP consists of didactic education and training in geriatrics and gerontology and in quality improvement (QI) and support to implement a local QI project; in addition, elective options include webinars, audio conferences, clinical practica, and mentoring. The program is effective in improving core competencies in geriatrics and in improving clinical care for older Veterans who receive health care in rural clinics. Adapted from the source document. JF - Gerontology & Geriatrics Education AU - Tumosa, Nina AU - Horvath, Kathy J AU - Huh, Terri AU - Livote, Elayne E AU - Howe, Judith L AU - Jones, Lauren Ila AU - Kramer, B Josea AD - Geriatric Research, Education & Clinical Center (GRECC), VA Greater Los Angeles Healthcare System, 16111 Plummer Street (11E), North Hills, CA 9134, USA Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 133 EP - 151 PB - Taylor & Francis, Philadelphia PA VL - 33 IS - 2 SN - 0270-1960, 0270-1960 KW - rural, workforce-training needs, primary care, continuing medical education, continuing education, continuous quality improvement KW - Veterans KW - Educational Programs KW - Rural Development KW - Geriatrics KW - Clinics KW - Primary Health Care KW - Mentoring KW - Rural Areas KW - Health Care Services KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266145537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gerontology+%26+Geriatrics+Education&rft.atitle=Health+Care+Workforce+Development+in+Rural+America%3A+When+Geriatrics+Expertise+Is+100+Miles+Away&rft.au=Tumosa%2C+Nina%3BHorvath%2C+Kathy+J%3BHuh%2C+Terri%3BLivote%2C+Elayne+E%3BHowe%2C+Judith+L%3BJones%2C+Lauren+Ila%3BKramer%2C+B+Josea&rft.aulast=Tumosa&rft.aufirst=Nina&rft.date=2012-04-01&rft.volume=33&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Gerontology+%26+Geriatrics+Education&rft.issn=02701960&rft_id=info:doi/10.1080%2F02701960.2012.661812 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-01-01 N1 - Last updated - 2016-09-28 N1 - CODEN - GGEDD6 N1 - SubjectsTermNotLitGenreText - Geriatrics; Health Care Services; Primary Health Care; Veterans; Rural Areas; Clinics; Mentoring; Rural Development; Educational Programs DO - http://dx.doi.org/10.1080/02701960.2012.661812 ER - TY - JOUR T1 - E-Readers: New Opportunities for Hospital Patients and Staff AN - 1125212927; 201210680 AB - E-readers provide an opportunity for hospital librarians to reach out to staff and patients with new approaches to library lending. Librarians in four Veterans Health Administration medical centers are using e-readers to enlarge their scope of service in unique ways. The libraries of VA hospitals in Minneapolis, Des Moines, Tampa, and Philadelphia have developed several ways to reach out to new library users. Adapted from the source document. JF - Medical Reference Services Quarterly AU - Stephenson, Priscilla L AU - Coady, Teresa R AU - Schneider, Janet M AU - Sinha, Dorothy P AD - Philadelphia VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104 priscilla.stephenson@va.gov Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 219 EP - 224 PB - Taylor & Francis, Philadelphia PA VL - 31 IS - 2 SN - 0276-3869, 0276-3869 KW - Bibliotherapy books, e-readers, handheld computers, patient libraries, staff development KW - Electronic book readers KW - Hospital patients KW - Bibliotherapy KW - Electronic books KW - Hospital libraries KW - article KW - 3.19: SCIENCE, TECHNOLOGY, MEDICINE LIBRARIES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125212927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Reference+Services+Quarterly&rft.atitle=E-Readers%3A+New+Opportunities+for+Hospital+Patients+and+Staff&rft.au=Stephenson%2C+Priscilla+L%3BCoady%2C+Teresa+R%3BSchneider%2C+Janet+M%3BSinha%2C+Dorothy+P&rft.aulast=Stephenson&rft.aufirst=Priscilla&rft.date=2012-04-01&rft.volume=31&rft.issue=2&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Medical+Reference+Services+Quarterly&rft.issn=02763869&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Bibliotherapy; Electronic book readers; Electronic books; Hospital patients; Hospital libraries ER - TY - JOUR T1 - Long-term outcomes of cognitive-behavioral treatments for posttraumatic stress disorder among female rape survivors. AN - 1023096102; 201217692 AB - Objective: We conducted a long-term follow-up (LTFU) assessment of participants from a randomized controlled trial comparing cognitive processing therapy (CPT) with prolonged exposure (PE) for posttraumatic stress disorder (PTSD). Competing hypotheses for positive outcomes (i.e., additional therapy, medication) were examined. Method: Intention-to-treat (ITT) participants were assessed 5-10 years after participating in the study (M = 6.15, SD = 1.22). We attempted to locate the 171 original participants, women with PTSD who had experienced at least one rape. Of 144 participants located, 87.5% were reassessed (N = 126), which constituted 73.7% of the original ITT sample. Self-reported PTSD symptoms were the primary outcome. Clinician-rated PTSD symptoms, comorbid diagnoses, and self-reported depression were secondary outcomes. Results: Substantial decreases in symptoms due to treatment (as reported in Resick, Nishith, Weaver, Astin, & Feuer, 2002) were maintained throughout the LTFU period, as evidenced by little change over time from posttreatment through follow-up (effect sizes ranging from pr = .03 to .14). No significant differences emerged during the LTFU between the treatment conditions (Cohen's d = 0.06-0.29). The ITT examination of diagnostics indicated that 22.2% of CPT and 17.5% of PE participants met the diagnosis for PTSD according to the Clinician-Administered PTSD Scale (Blake et al., 1995) at the LTFU. Maintenance of improvements could not be attributed to further therapy or medications. Conclusions: CPT and PE resulted in lasting changes in PTSD and related symptoms over an extended period of time for female rape victims with extensive histories of trauma. [Copyright American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Resick, Patricia A AU - Williams, Lauren F AU - Suvak, Michael K AU - Monson, Candice M AU - Gradus, Jaimie L AD - National Center for PTSD/VA Boston Healthcare System patricia.resick@va.gov Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 201 EP - 210 PB - American Psychological Association, Washington DC VL - 80 IS - 2 SN - 0022-006X, 0022-006X KW - Cognitive Behavior Therapy KW - Posttraumatic Stress Disorder KW - Rape KW - Survivors KW - Human Females KW - Symptoms KW - Randomized controlled trials KW - Posttraumatic stress disorder KW - Long term effects KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023096102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=Long-term+outcomes+of+cognitive-behavioral+treatments+for+posttraumatic+stress+disorder+among+female+rape+survivors.&rft.au=Resick%2C+Patricia+A%3BWilliams%2C+Lauren+F%3BSuvak%2C+Michael+K%3BMonson%2C+Candice+M%3BGradus%2C+Jaimie+L&rft.aulast=Resick&rft.aufirst=Patricia&rft.date=2012-04-01&rft.volume=80&rft.issue=2&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2Fa0026602 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Symptoms; Rape; Long term effects; Comorbidity; Randomized controlled trials DO - http://dx.doi.org/10.1037/a0026602 ER - TY - JOUR T1 - Is Past Depression Or Current Dysphoria Associated With Social Perception? AN - 1023094467; 201214777 AB - The depressive realism hypothesis holds that depressed individuals often make more accurate assessments of reality than nondepressed individuals. Previous depressive realism studies have not examined history of depression separately from current dysphoric mood and have been criticized for lacking external validity and an objective standard for measuring accuracy. In this study, 104 participants classified by current dysphoric mood and history of depression watched videotaped segments of actual dates and predicted whether daters would want to date again. Predictions were compared with daters' stated preferences. Results did not support the depressive realism hypothesis for dysphoric participants. However, results indicated that those with past depression were more accurate than those without a depression history when making negative but not positive predictions. Adapted from the source document. JF - Journal of Social and Clinical Psychology AU - Greenawalt, David S AU - Hayes, Adele M AD - VISN 17 Center of Excellence for Research on Returning War Veterans, 4800 Memorial Drive (151C), Waco, TX 76711 david.greenawalt@va.gov Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 329 EP - 355 PB - Guilford Press, New York NY VL - 31 IS - 4 SN - 0736-7236, 0736-7236 KW - Assessment KW - Depression KW - Preferences KW - Social perception KW - Moods KW - Realism KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023094467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+and+Clinical+Psychology&rft.atitle=Is+Past+Depression+Or+Current+Dysphoria+Associated+With+Social+Perception%3F&rft.au=Greenawalt%2C+David+S%3BHayes%2C+Adele+M&rft.aulast=Greenawalt&rft.aufirst=David&rft.date=2012-04-01&rft.volume=31&rft.issue=4&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+and+Clinical+Psychology&rft.issn=07367236&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSCPFF N1 - SubjectsTermNotLitGenreText - Depression; Realism; Moods; Assessment; Social perception; Preferences ER - TY - JOUR T1 - Correlates of intimate partner psychological aggression perpetration in a clinical sample of alcoholic men AN - 1023093865; 201215524 AB - This study longitudinally examined correlates of intimate partner psychological aggression in a sample of 178 men seeking treatment for alcoholism and their partners, building on a previous investigation examining correlates of intimate partner physical aggression (Taft et al., 2010). The men were largely Caucasian; average age was 41.0 years. Participants completed a battery of questionnaires that assessed distal and proximal predictors of psychological aggression perpetration. Distal factors, assessed at baseline, included initial alcohol problem severity, beliefs about alcohol, and antisocial personality characteristics. Proximal factors, assessed at baseline and at follow-ups 6 and 12 months later, included alcohol and drug use, relationship adjustment, and anger. Psychological aggression was assessed at all three time points. Findings showed that both groups of variables were associated with psychological aggression perpetration. Beliefs that drinking causes relationship problems and variables related to alcohol consumption exhibited the strongest associations with psychological aggression. The findings are consistent with theoretical models that emphasize both distal and proximal effects of drinking on intimate partner aggression. Implications for clinical interventions and directions for future research are discussed. [Copyright The American Psychological Association.] JF - Journal of Family Psychology AU - Kachadourian, Lorig K AU - Taft, Casey T AU - O'Farrell, Timothy J AU - Doron-LaMarca, Susan AU - Murphy, Christopher M AD - National Center for PTSD, VA Boston Healthcare System lorig.kachadourian@va.gov Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 206 EP - 214 PB - American Psychological Association, Washington DC VL - 26 IS - 2 SN - 0893-3200, 0893-3200 KW - alcoholic men KW - psychological aggression perpetration KW - relationship adjustment KW - intimate partner KW - Alcohol consumption KW - Men KW - Psychic assault KW - Alcoholism KW - Aggression KW - Intimate relationships KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023093865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Psychology&rft.atitle=Correlates+of+intimate+partner+psychological+aggression+perpetration+in+a+clinical+sample+of+alcoholic+men&rft.au=Kachadourian%2C+Lorig+K%3BTaft%2C+Casey+T%3BO%27Farrell%2C+Timothy+J%3BDoron-LaMarca%2C+Susan%3BMurphy%2C+Christopher+M&rft.aulast=Kachadourian&rft.aufirst=Lorig&rft.date=2012-04-01&rft.volume=26&rft.issue=2&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Psychology&rft.issn=08933200&rft_id=info:doi/10.1037%2Fa0027436 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JFPSEV N1 - SubjectsTermNotLitGenreText - Psychic assault; Alcohol consumption; Men; Intimate relationships; Alcoholism; Aggression DO - http://dx.doi.org/10.1037/a0027436 ER - TY - JOUR T1 - Chronic Insomnia and Health Care Utilization in Young Adults AN - 1023090479; 201213039 AB - Chronic insomnia is prevalent, contributes a significant economic burden, and people with insomnia have increased health care utilization (HCU). The purpose of this study was to investigate the relationship between chronic insomnia and HCU in a population with fewer medical/mental health problems, using current operational definitions of chronic insomnia and multiple measures of HCU. Participants with chronic insomnia had greater HCU than normal sleepers. Participants with chronic insomnia plus a comorbid condition had greater HCU than normal sleepers with a medical/mental health problem and participants with only chronic insomnia. The relationship between chronic insomnia and HCU was moderated by comorbid medical/mental health problems. Early identification and intervention of chronic insomnia may help reduce HCU and costs associated with chronic insomnia. Adapted from the source document. JF - Behavioral Sleep Medicine AU - Bramoweth, Adam D AU - Taylor, Daniel J AD - VA Pittsburgh Healthcare System, 7180 Highland Drive, 151R-H, Pittsburgh, PA 15206 adam.bramoweth@va.gov Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 106 EP - 121 PB - Routledge/Taylor & Francis, Philadelphia, PA VL - 10 IS - 2 SN - 1540-2002, 1540-2002 KW - Health costs KW - Chronic insomnia KW - Early intervention programmes KW - Psychiatric disorders KW - Comorbidity KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023090479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sleep+Medicine&rft.atitle=Chronic+Insomnia+and+Health+Care+Utilization+in+Young+Adults&rft.au=Bramoweth%2C+Adam+D%3BTaylor%2C+Daniel+J&rft.aulast=Bramoweth&rft.aufirst=Adam&rft.date=2012-04-01&rft.volume=10&rft.issue=2&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sleep+Medicine&rft.issn=15402002&rft_id=info:doi/10.1080%2F15402002.2011.587067 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Chronic insomnia; Psychiatric disorders; Helpseeking; Comorbidity; Early intervention programmes; Health costs DO - http://dx.doi.org/10.1080/15402002.2011.587067 ER - TY - JOUR T1 - The relationship of locus of control, self-control, and acceptable noise levels for young listeners with normal hearing AN - 1023037695; 201209336 AB - Objective: Background noise acceptance while listening to speech, assessed via the acceptable noise level (ANL) measure, has been shown to be an accurate predictor of hearing-aid success. No specific listener characteristics have been identified as being related to a listener's ability to accept background noise. The purpose of this study was to determine whether or not locus of control and self-control are related to ANL. Design: Correlational design. Study sample: Participants were seventy young adults (21 male, 49 female; aged 19 to 39 years) with normal hearing. Participants completed psychological profiles that evaluated locus of control and self-control and their ANLs were measured. Results: Results revealed correlations between ANL and self-control. Listeners with higher levels of self-control accepted more background noise than listeners with lower levels of self-control. Conclusions: This research suggests that exercises aimed at strengthening a listener's auditory self-control may lead to improved background noise acceptance. Improvement in background noise acceptance could lead to improved hearing-aid success. Future research should explore these possibilities. Adapted from the source document JF - International Journal of Audiology AU - Nichols, Amy Comerford AU - Gordon-Hickey, Susan AD - Veterans Affairs Outpatient Clinic, Joint Ambulatory Care Center, Audiology Department (126P) amy.comerford@va.gov Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 353 EP - 359 VL - 51 IS - 4 SN - 1499-2027, 1499-2027 KW - Hearing (31150) KW - Noise (58100) KW - Children (11850) KW - article KW - 6310: hearing-pathological and normal; hearing-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023037695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=The+relationship+of+locus+of+control%2C+self-control%2C+and+acceptable+noise+levels+for+young+listeners+with+normal+hearing&rft.au=Nichols%2C+Amy+Comerford%3BGordon-Hickey%2C+Susan&rft.aulast=Nichols&rft.aufirst=Amy&rft.date=2012-04-01&rft.volume=51&rft.issue=4&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Children (11850); Noise (58100); Hearing (31150) ER - TY - JOUR T1 - The relationship between cognitive impairment and diabetes self-management in a population-based community sample of older adults with Type 2 diabetes AN - 1018376921; 201210551 AB - Although nearly one-third of older diabetics are cognitively impaired, their diabetes management remains poorly understood. To examine the relationship between cognitive impairment and diabetes self-management in a population-based community sample of older adults with Type 2 diabetes. Cross-sectional observational analysis. 1,398 persons with diabetes, aged 60 years or older, who responded to the 2003 Health and Retirement Study Diabetes Survey. We conducted logistic regressions on the effects of cognitive impairment on respondents' self-management ability after controlling for diabetes comorbidities, demographics, and clinical characteristics. Participants with greater cognitive impairment were less likely to adhere to exercise (Adjusted Odds ratio [AOR] = 0.725 and 0.712 for moderate and severe cognitive impairment, both P < 0.05), and to diet (AOR = 0.906 and 0.618 for moderate and severe cognitive impairment, both P < 0.01). Cognitive impairment is associated with worse self-care and may pose challenges to diabetic older persons, notably in diet and exercise. Cognitive screening may be indicated in this high risk group. Adapted from the source document. JF - Journal of Behavioral Medicine AU - Feil, Denise G AU - Zhu, Carolyn W AU - Sultzer, David L AD - Department of Psychiatry and Biobehavioral Sciences, Greater Los Angeles VA Healthcare System, West L.A. Veterans Health Care Center, UCLA, 11301 Wilshire Blvd., Bldg. 401 116-AE, Los Angeles, CA, 90073, USA denise.feil@va.gov Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 190 EP - 199 PB - Springer Science+Business Media, Inc., Dordrecht, The Netherlands VL - 35 IS - 2 SN - 0160-7715, 0160-7715 KW - Diabetics KW - Elderly people KW - Selfmanagement KW - Type 2 diabetes mellitus KW - Exercise KW - Cognitive impairment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018376921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Medicine&rft.atitle=The+relationship+between+cognitive+impairment+and+diabetes+self-management+in+a+population-based+community+sample+of+older+adults+with+Type+2+diabetes&rft.au=Feil%2C+Denise+G%3BZhu%2C+Carolyn+W%3BSultzer%2C+David+L&rft.aulast=Feil&rft.aufirst=Denise&rft.date=2012-04-01&rft.volume=35&rft.issue=2&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Medicine&rft.issn=01607715&rft_id=info:doi/10.1007%2Fs10865-011-9344-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JBMEDD N1 - SubjectsTermNotLitGenreText - Cognitive impairment; Type 2 diabetes mellitus; Elderly people; Selfmanagement; Exercise; Diabetics DO - http://dx.doi.org/10.1007/s10865-011-9344-6 ER - TY - JOUR T1 - A Brief Treatment Engagement Intervention for Individuals with Co-occurring Mental Illness and Substance Use Disorders: Results of a Randomized Clinical Trial AN - 1018344716; 201202693 AB - Study objectives were to evaluate a brief intervention designed to facilitate outpatient engagement following an inpatient psychiatric stay for individuals with mental illness and substance use. A total of 102 veterans were randomly assigned to one of two conditions: (1) Time Limited Care-Coordination (TLC), an eight-week co-occurring disorders intervention or (2) a matched attention (MA) control condition in the form of health education sessions. Both groups also received treatment as usual in inpatient and outpatient settings. Sixty-nine percent of TLC participants attended an outpatient appointment within 14 days of discharge, compared to only 33% of MA participants (P < 0.01). TLC participants were also more likely to be engaged in outpatient services at the end of the intervention period (44 vs. 22%, P < 0.01). This study provided evidence that an eight-week intervention could improve treatment engagement. Research is currently underway to examine impact of TLC intervention beyond the 8 week study period. Adapted from the source document. JF - Community Mental Health Journal AU - Smelson, David AU - Kalman, David AU - Losonczy, Miklos F AU - Kline, Anna AU - Sambamoorthi, Usha AU - St Hill, Lauren AU - Castles-Fonseca, Kathy AU - Ziedonis, Douglas AD - Center for Health, Quality, Outcomes and Economic Research, Edith Norse Rogers VA Medical Center, 200 Springs Road, Bedford, MA, 01730, USA david.smelson@va.gov Y1 - 2012/04// PY - 2012 DA - April 2012 SP - 127 EP - 132 PB - Springer, Dordrecht The Netherlands VL - 48 IS - 2 SN - 0010-3853, 0010-3853 KW - Veterans KW - Outpatients KW - Substance Abuse KW - Medical Research KW - Intervention KW - Health Education KW - Mental Illness KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018344716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=A+Brief+Treatment+Engagement+Intervention+for+Individuals+with+Co-occurring+Mental+Illness+and+Substance+Use+Disorders%3A+Results+of+a+Randomized+Clinical+Trial&rft.au=Smelson%2C+David%3BKalman%2C+David%3BLosonczy%2C+Miklos+F%3BKline%2C+Anna%3BSambamoorthi%2C+Usha%3BSt+Hill%2C+Lauren%3BCastles-Fonseca%2C+Kathy%3BZiedonis%2C+Douglas&rft.aulast=Smelson&rft.aufirst=David&rft.date=2012-04-01&rft.volume=48&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-010-9346-9 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-28 N1 - CODEN - CMHJAY N1 - SubjectsTermNotLitGenreText - Intervention; Outpatients; Mental Illness; Substance Abuse; Health Education; Medical Research; Veterans DO - http://dx.doi.org/10.1007/s10597-010-9346-9 ER - TY - JOUR T1 - Francisella tularensis Inhibits the Intrinsic and Extrinsic Pathways To Delay Constitutive Apoptosis and Prolong Human Neutrophil Lifespan AN - 1008834561; 16511731 AB - Francisella tularensis is a facultative intracellular bacterium that infects many cell types, including neutrophils. We demonstrated previously that F. tularensis inhibits NADPH oxidase assembly and activity and then escapes the phagosome to the cytosol, but effects on other aspects of neutrophil function are unknown. Neutrophils are short-lived cells that undergo constitutive apoptosis, and phagocytosis typically accelerates this process. We now demonstrate that F. tularensis significantly inhibited neutrophil apoptosis as indicated by morphologic analysis as well as annexin V and TUNEL staining. Thus, similar to 80% of infected neutrophils remained viable at 48 h compared with similar to 50% of control cells, and similar to 40% of neutrophils that ingested opsonized zymosan. In keeping with this finding, processing and activation of procaspases-8, -9, and -3 were markedly diminished and delayed. F. tularensis also significantly impaired apoptosis triggered by Fas crosslinking. Of note, these effects were dose dependent and could be conferred by either intracellular or extracellular live bacteria, but not by formalin-killed organisms or isolated LPS and capsule, and were not affected by disruption of wbtA2 or FTT1236/FTL0708-genes required for LPS O-antigen and capsule biosynthesis. In summary, we demonstrate that F. tularensis profoundly impairs constitutive neutrophil apoptosis via effects on the intrinsic and extrinsic pathways, and thereby define a new aspect of innate immune evasion by this organism. As defects in neutrophil turnover prevent resolution of inflammation, our findings also suggest a mechanism that may in part account for the neutrophil accumulation, granuloma formation, and severe tissue damage that characterizes lethal pneumonic tularemia. JF - Journal of Immunology AU - Schwartz, Justin T AU - Barker, Jason H AU - Kaufman, Justin AU - Fayram, Drew C AU - McCracken, Jenna M AU - Allen, Lee-Ann H AD - Inflammation Program, University of Iowa and the Veterans Administration Medical Center, Iowa City, IA 52242 Y1 - 2012/04/01/ PY - 2012 DA - 2012 Apr 01 SP - 3351 EP - 3363 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 United States VL - 188 IS - 7 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Apoptosis KW - Phagosomes KW - Life span KW - Leukocytes (neutrophilic) KW - Francisella tularensis KW - Granuloma KW - Inflammation KW - Tularemia KW - Fas antigen KW - Cytosol KW - CD95 antigen KW - Lipopolysaccharides KW - NAD(P)H oxidase KW - Phagocytosis KW - Annexin V KW - Opsonization KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008834561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Francisella+tularensis+Inhibits+the+Intrinsic+and+Extrinsic+Pathways+To+Delay+Constitutive+Apoptosis+and+Prolong+Human+Neutrophil+Lifespan&rft.au=Schwartz%2C+Justin+T%3BBarker%2C+Jason+H%3BKaufman%2C+Justin%3BFayram%2C+Drew+C%3BMcCracken%2C+Jenna+M%3BAllen%2C+Lee-Ann+H&rft.aulast=Schwartz&rft.aufirst=Justin&rft.date=2012-04-01&rft.volume=188&rft.issue=7&rft.spage=3351&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Apoptosis; Life span; Phagosomes; Leukocytes (neutrophilic); Granuloma; Inflammation; Tularemia; Fas antigen; Cytosol; Lipopolysaccharides; CD95 antigen; NAD(P)H oxidase; Phagocytosis; Annexin V; Opsonization; Francisella tularensis ER - TY - JOUR T1 - Healthcare costs of methicillin resistant Staphylococcus aureus and Pseudomonas aeruginosa infections in veterans: role of vitamin D deficiency AN - 968168736; 16324791 AB - Methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P. aeruginosa) infections are frequently associated with hospitalization and increased healthcare costs. Vitamin D deficiency may contribute to increased costs for patients with these infections and there is evidence that vitamin D may have an antimicrobial role. To evaluate the role of vitamin D deficiency in the costs incurred with these infections, we studied the relationship of serum 25(OH)D levels to healthcare costs in veterans in the southeastern United States. Patients with both infections were vitamin D deficient to a similar extent and so were combined for further analysis. Vitamin D deficient patients had higher costs and service utilization than those who were not vitamin D deficient. Those with vitamin D deficiency had higher inpatient costs compared to the non-deficient group, and this difference was across most categories except for the number of inpatient hospitalizations or total number of days as an inpatient. Vitamin D deficiency was not significantly related to outpatient cost or service utilization parameters. We conclude that vitamin D deficiency is intimately linked to adverse healthcare costs in veterans with MRSA and P. aeruginosa infections. Vitamin D status should be assayed in patients with these infections. JF - European Journal of Clinical Microbiology & Infectious Diseases AU - Youssef, D AU - Bailey, B AU - El-Abbassi, A AU - Vannoy, M AU - Manning, T AU - Moorman, J P AU - Peiris, AN AD - Department of Internal Medicine, Division of Infectious Diseases, East Tennessee State University, Johnson City, TN, USA, Alan.peiris@va.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 281 EP - 286 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 31 IS - 3 SN - 0934-9723, 0934-9723 KW - Microbiology Abstracts B: Bacteriology KW - Antimicrobial agents KW - Drug resistance KW - Infection KW - Methicillin KW - Nutrient deficiency KW - Vitamin D KW - Pseudomonas aeruginosa KW - Staphylococcus aureus KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968168736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.atitle=Healthcare+costs+of+methicillin+resistant+Staphylococcus+aureus+and+Pseudomonas+aeruginosa+infections+in+veterans%3A+role+of+vitamin+D+deficiency&rft.au=Youssef%2C+D%3BBailey%2C+B%3BEl-Abbassi%2C+A%3BVannoy%2C+M%3BManning%2C+T%3BMoorman%2C+J+P%3BPeiris%2C+AN&rft.aulast=Youssef&rft.aufirst=D&rft.date=2012-03-01&rft.volume=31&rft.issue=3&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.issn=09349723&rft_id=info:doi/10.1007%2Fs10096-011-1308-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Nutrient deficiency; Methicillin; Vitamin D; Drug resistance; Infection; Antimicrobial agents; Staphylococcus aureus; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1007/s10096-011-1308-9 ER - TY - JOUR T1 - Are two ears not better than one? AN - 963836776; pmid-22436115 AB - The decision to fit one or two hearing aids in individuals with binaural hearing loss has been debated for years. Although some 78% of U.S. hearing aid fittings are binaural (Kochkin , 2010), Walden and Walden (2005) presented data showing that 82% (23 of 28 patients) of their sample obtained significantly better speech recognition in noise scores when wearing one hearing aid as opposed to two.To conduct two new experiments to fuel the monaural/binaural debate. The first experiment was a replication of Walden and Walden (2005), whereas the second experiment examined the use of binaural cues to improve speech recognition in noise.A repeated measures experimental design.Twenty veterans (aged 59-85 yr), with mild to moderately severe binaurally symmetrical hearing loss who wore binaural hearing aids were recruited from the Audiology Department at the Bay Pines VA Healthcare System.Experiment 1 followed the procedures of the Walden and Walden study, where signal-to-noise ratio (SNR) loss was measured using the Quick Speech-in-Noise (QuickSIN) test on participants who were aided with their current hearing aids. Signal and noise were presented in the sound booth at 0° azimuth under five test conditions: (1) right ear aided, (2) left ear aided, (3) both ears aided, (4) right ear aided, left ear plugged, and (5) unaided. The opposite ear in (1) and (2) was left open. In Experiment 2, binaural Knowles Electronics Manikin for Acoustic Research (KEMAR) manikin recordings made in Lou Malnati's pizza restaurant during a busy period provided a typical real-world noise, while prerecorded target sentences were presented through a small loudspeaker located in front of the KEMAR manikin. Subjects listened to the resulting binaural recordings through insert earphones under the following four conditions: (1) binaural, (2) diotic, (3) monaural left, and (4) monaural right.Results of repeated measures ANOVAs demonstrated that the best speech recognition in noise performance was obtained by most participants with both ears aided in Experiment 1 and in the binaural condition in Experiment 2.In both experiments, only 20% of our subjects did better in noise with a single ear, roughly similar to the earlier Jerger et al (1993) finding that 8-10% of elderly hearing aid users preferred one hearing aid.American Academy of Audiology. JF - Journal of the American Academy of Audiology AU - McArdle, Rachel A AU - Killion, Mead AU - Mennite, Monica A AU - Chisolm, Theresa H AD - Bay Pines VA Healthcare System, Bay Pines, FL, USA. Rachel.mcardle@va.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 171 EP - 181 VL - 23 IS - 3 SN - 1050-0545, 1050-0545 KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - *Hearing Aids KW - *Hearing Loss, Bilateral: physiopathology KW - *Hearing Loss, Bilateral: rehabilitation KW - Humans KW - Male KW - Middle Aged KW - Patient Preference KW - Prospective Studies KW - *Sound Localization: physiology KW - *Speech Perception: physiology KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/963836776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Are+two+ears+not+better+than+one%3F&rft.au=McArdle%2C+Rachel+A%3BKillion%2C+Mead%3BMennite%2C+Monica+A%3BChisolm%2C+Theresa+H&rft.aulast=McArdle&rft.aufirst=Rachel&rft.date=2012-03-01&rft.volume=23&rft.issue=3&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2012-05-14 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Passive mechanical properties and related proteins change with botulinum neurotoxin A injection of normal skeletal muscle. AN - 917572652; 21853457 AB - The effects of botulinum neurotoxin A on the passive mechanical properties of skeletal muscle have not been investigated, but may have significant impact in the treatment of neuromuscular disorders including spasticity. Single fiber and fiber bundle passive mechanical testing was performed on rat muscles treated with botulinum neurotoxin A. Myosin heavy chain and titin composition of single fibers was determined by gel electrophoresis. Muscle collagen content was determined using a hydroxyproline assay. Neurotoxin-treated single fiber passive elastic modulus was reduced compared to control fibers (53.00 kPa vs. 63.43 kPa). Fiber stiffness and slack sarcomere length were also reduced compared to control fibers and myosin heavy chain composition shifted from faster to slower isoforms. Average titin molecular weight increased 1.77% after treatment. Fiber bundle passive elastic modulus increased following treatment (168.83  kPa vs. 75.14 kPa). Bundle stiffness also increased while collagen content per mass of muscle tissue increased 38%. Injection of botulinum neurotoxin A produces an effect on the passive mechanical properties of normal muscle that is opposite to the changes observed in spastic muscles. Copyright © 2011 Orthopaedic Research Society. JF - Journal of orthopaedic research : official publication of the Orthopaedic Research Society AU - Thacker, Bryan E AU - Tomiya, Akihito AU - Hulst, Jonah B AU - Suzuki, Kentaro P AU - Bremner, Shannon N AU - Gastwirt, Randy F AU - Greaser, Marion L AU - Lieber, Richard L AU - Ward, Samuel R AD - Department of Bioengineering, University of California and Veterans Administration Medical Centers San Diego, La Jolla, California, USA. Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 497 EP - 502 VL - 30 IS - 3 KW - Connectin KW - 0 KW - Muscle Proteins KW - Protein Isoforms KW - Protein Kinases KW - EC 2.7.- KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Myosin Heavy Chains KW - EC 3.6.4.1 KW - Index Medicus KW - Rats KW - Muscle Proteins -- metabolism KW - Protein Kinases -- metabolism KW - Animals KW - Rats, Sprague-Dawley KW - Muscle Spasticity -- drug therapy KW - Protein Isoforms -- metabolism KW - Myosin Heavy Chains -- metabolism KW - Drug Evaluation, Preclinical KW - Male KW - Elastic Modulus -- drug effects KW - Botulinum Toxins, Type A -- therapeutic use KW - Botulinum Toxins, Type A -- pharmacology KW - Muscle, Skeletal -- metabolism KW - Muscle, Skeletal -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/917572652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+orthopaedic+research+%3A+official+publication+of+the+Orthopaedic+Research+Society&rft.atitle=Passive+mechanical+properties+and+related+proteins+change+with+botulinum+neurotoxin+A+injection+of+normal+skeletal+muscle.&rft.au=Thacker%2C+Bryan+E%3BTomiya%2C+Akihito%3BHulst%2C+Jonah+B%3BSuzuki%2C+Kentaro+P%3BBremner%2C+Shannon+N%3BGastwirt%2C+Randy+F%3BGreaser%2C+Marion+L%3BLieber%2C+Richard+L%3BWard%2C+Samuel+R&rft.aulast=Thacker&rft.aufirst=Bryan&rft.date=2012-03-01&rft.volume=30&rft.issue=3&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Journal+of+orthopaedic+research+%3A+official+publication+of+the+Orthopaedic+Research+Society&rft.issn=1554-527X&rft_id=info:doi/10.1002%2Fjor.21533 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-12 N1 - Date created - 2012-01-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurol Neurosurg Psychiatry. 2004 Jul;75(7):951-7 [15201348] Dev Med Child Neurol. 2001 May;43(5):314-20 [11368484] Am J Physiol Regul Integr Comp Physiol. 2001 Nov;281(5):R1710-7 [11641144] Eur J Neurol. 2001 Nov;8 Suppl 5:50-8 [11851734] Muscle Nerve. 2003 Feb;27(2):157-64 [12548522] Electrophoresis. 2003 Jun;24(11):1695-702 [12783444] Muscle Nerve. 2003 Oct;28(4):464-71 [14506719] Clin Chim Acta. 1980 Jun 10;104(2):161-7 [7389130] J Morphol. 1992 May;212(2):109-22 [1608046] Biophys J. 1993 Apr;64(4):1161-77 [8494977] Nature. 1993 Sep 9;365(6442):160-3 [8103915] J Appl Physiol (1985). 1993 Nov;75(5):2337-40 [8307894] Biophys J. 1994 Aug;67(2):782-92 [7948691] J Neurol Neurosurg Psychiatry. 1994 Nov;57(11):1321-4 [7964805] Biophys J. 1995 Mar;68(3):1027-44 [7756523] Am J Physiol. 1997 Jul;273(1 Pt 1):C266-76 [9252465] Toxicon. 2005 Aug;46(2):196-203 [15975617] J Gen Physiol. 2005 Nov;126(5):461-80 [16230467] J Physiol. 2006 Nov 15;577(Pt 1):339-52 [16931550] Dev Med Child Neurol. 2007 Dec;49(12):907-14 [18039237] Circ Res. 2000 Jun 9;86(11):1114-21 [10850961] J Pain Symptom Manage. 2000 Jul;20(1):44-9 [10946168] J Exp Biol. 2001 May;204(Pt 9):1529-36 [11296141] Acta Physiol Scand. 2001 Jun;172(2):131-40 [11442453] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jor.21533 ER - TY - JOUR T1 - Lactate dyscrasia: a novel explanation for amyotrophic lateral sclerosis. AN - 916521862; 20541840 AB - Amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) is a progressive debilitating neurodegenerative disease with no cure. We propose a novel molecular model for the pathogenesis of ALS that involves an adenosine triphosphate (ATP)-dependent muscle neuronal lactate shuttle (MNLS) at the neuromuscular junction (NMJ) to regulate the flow of lactate from muscle to neurons and vice versa. Failure of the MNLS due to respiratory chain dysfunction is proposed to result in lactate toxicity and degeneration of nerve endings at the NMJ leading to nerve terminus dysjunction from the muscle cell. At a critical threshold where denervation outpaces reinnervation, a vicious cycle is established where the remaining innervated muscle fibers are required to work harder to compensate for normal function, and in so doing produce toxic lactate concentrations which induces further denervation and neuronal death. This mechanism explains the exponential progression of ALS leading to paralysis. The molecular events leading to the dysregulation of the MNLS and the dismantling of NMJ are explained in the context of known ALS familial mutations and age-related endocrine dyscrasia. Combination drug therapies that inhibit lactate accumulation at the NMJ, enhance respiratory chain function, and/or promote reinnervation are predicted to be effective therapeutic strategies for ALS. Published by Elsevier Inc. JF - Neurobiology of aging AU - Vadakkadath Meethal, Sivan AU - Atwood, Craig S AD - Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA. Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 569 EP - 581 VL - 33 IS - 3 KW - Lactic Acid KW - 33X04XA5AT KW - Index Medicus KW - Animals KW - Mitochondrial Diseases -- physiopathology KW - Mitochondrial Diseases -- metabolism KW - Nerve Degeneration -- metabolism KW - Nerve Degeneration -- physiopathology KW - Humans KW - Mitochondrial Diseases -- etiology KW - Nerve Degeneration -- etiology KW - Amyotrophic Lateral Sclerosis -- metabolism KW - Amyotrophic Lateral Sclerosis -- etiology KW - Lactic Acid -- metabolism KW - Amyotrophic Lateral Sclerosis -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916521862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+aging&rft.atitle=Lactate+dyscrasia%3A+a+novel+explanation+for+amyotrophic+lateral+sclerosis.&rft.au=Vadakkadath+Meethal%2C+Sivan%3BAtwood%2C+Craig+S&rft.aulast=Vadakkadath+Meethal&rft.aufirst=Sivan&rft.date=2012-03-01&rft.volume=33&rft.issue=3&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+aging&rft.issn=1558-1497&rft_id=info:doi/10.1016%2Fj.neurobiolaging.2010.04.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-09-28 N1 - Date created - 2012-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neurobiolaging.2010.04.012 ER - TY - JOUR T1 - Echocardiogram Utilization Among Rural and Urban Veterans AN - 1748688111 AB - Purpose:To compare echocardiography use among urban and rural veterans and whether differences could be accounted for by distance. Methods:We used Veterans Administration (VA) administrative data from 1999 to 2007 to identify regular users of the VA Healthcare System (VA users) who did and did not receive echocardiography. Each veteran was categorized as residing in urban, rural or highly rural areas using RUCA codes. Poisson regression was used to compare echocardiography utilization rates among veterans residing in each area after adjusting for demographics, comorbidities, clustering of patients within VA networks and distance to the nearest VA medical center offering echocardiography. Findings:Our study included 22.7 million veterans of whom 1.3 million (5.7%) received at least 1 echocardiogram. Of echocardiography recipients, 69.2% lived in urban, 22.0% in rural and 8.8% in highly rural areas. In analyses adjusting for patient demographics, comorbidities, and clustering, utilization of echocardiography was modestly lower for highly rural and rural veterans compared with urban veterans (42.0 vs 40.1 vs 43.1 echocardiograms per 1,000 VA users per year for highly rural, rural and urban, respectively; P< .001). After further adjusting for distance, echocardiography utilization was somewhat higher for veterans in highly rural and rural areas than it was for urban areas (44.9 vs 41.8 vs 40.8 for highly rural, rural and urban, respectively; P< .001). Conclusions:Echocardiography utilization among rural and highly rural veterans was marginally lower than for urban veterans, but these differences can be accounted for by the greater distance of more rural veterans from facilities offering echocardiograms. JF - The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association AU - Okrah, Kingston AU - Vaughan-Sarrazin, Mary AU - Kaboli, Peter AU - Cram, Peter AD - Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa., Center for Comprehensive Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Administration Medical Center, Iowa City, Iowa., Division of General Internal Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa. ; Center for Comprehensive Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Administration Medical Center, Iowa City, Iowa., Division of General Internal Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa. ; Center for Comprehensive Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Administration Medical Center, Iowa City, Iowa., Division of General Internal Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa., VA Office of Rural Health (ORH), Veterans Rural Health Resource Center-Central Region, Iowa City VAMC, Iowa City, Iowa. ; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.; Center for Comprehensive Access and Delivery Research and Evaluation (CADRE), Iowa City Veterans Administration Medical Center, Iowa City, Iowa.; Division of General Internal Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa. Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 211 EP - 220 CY - Washington PB - Wiley Subscription Services, Inc. VL - 28 IS - 2 SN - 0890-765X KW - Public Health And Safety KW - Clustering KW - Management KW - Government Agencies KW - Methodology (Data Analysis) KW - Health Care Services Policy KW - Networks KW - Patients KW - Urban Areas KW - Rural Areas KW - Rural Urban Differences KW - Veterans KW - Echocardiography KW - Health care KW - Military hospitals KW - Rural areas KW - Rural communities KW - Urban areas UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1748688111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.atitle=Echocardiogram+Utilization+Among+Rural+and+Urban+Veterans&rft.au=Okrah%2C+Kingston%3BVaughan-Sarrazin%2C+Mary%3BKaboli%2C+Peter%3BCram%2C+Peter&rft.aulast=Okrah&rft.aufirst=Kingston&rft.date=2012-03-01&rft.volume=28&rft.issue=2&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2011.00380.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); PAIS Index N1 - Name - Department of Veterans Affairs N1 - Date revised - 2014-11-10 N1 - Last updated - 2016-05-24 DO - http://dx.doi.org/10.1111/j.1748-0361.2011.00380.x ER - TY - JOUR T1 - Predictors of postdeployment alcohol use disorders in National Guard soldiers deployed to Operation Iraqi Freedom. AN - 1449098584; 201323903 AB - Alcohol use in the military is a significant problem. The goal of this study was to examine the associations between personality, posttraumatic stress disorder (PTSD) symptoms, and postdeployment alcohol use disorders (AUDs) among a group of Operation Iraqi Freedom (OIF) deployed National Guard soldiers, with a focus on differentiating predeployment and postdeployment onset AUDs. Participants were 348 National Guard soldiers deployed to Iraq from March 2006 to July 2007 drawn from the Readiness and Resilience in National Guard Soldiers (RINGS) study. Participants completed self-report measures one month before deployment and 3 to 6 months postdeployment; current and lifetime history of AUDs were assessed 6 to 12 months postdeployment, using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders (4th ed. text rev.; DSM-IV; American Psychiatric Association, 2000). Overall, 13% of the panel was diagnosed with a current AUD. Of those who met criteria for a current AUD, 38% had an AUD that developed following return from deployment (new onset AUD). The development of new onset AUDs was uniquely predicted by higher levels of PTSD symptom severity, higher levels of avoidance-specific PTSD symptoms, and lower levels of positive emotionality. AUDs with onset prior to deployment were predicted by higher levels of negative emotionality and disconstraint. Results of this study suggest that combat deployed soldiers with current AUDs are a heterogeneous group and point to the influence of combat-related PTSD symptoms in the development of AUDs following deployment. [Copyright The American Psychological Association.] JF - Psychology of Addictive Behaviors AU - Kehle, Shannon M AU - Ferrier-Auerbach, Amanda G AU - Meis, Laura A AU - Arbisi, Paul A AU - Erbes, Christopher R AU - Polusny, Melissa A Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 42 EP - 50 PB - American Psychological Association, Washington DC VL - 26 IS - 1 SN - 0893-164X, 0893-164X KW - alcohol use disorders KW - posttraumatic stress disorder KW - veterans KW - Operation Iraqi Freedom KW - postdeployment KW - Symptoms KW - Posttraumatic stress disorder KW - Soldiers KW - Freedom KW - Emotionality KW - Deployment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1449098584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Addictive+Behaviors&rft.atitle=Predictors+of+postdeployment+alcohol+use+disorders+in+National+Guard+soldiers+deployed+to+Operation+Iraqi+Freedom.&rft.au=Kehle%2C+Shannon+M%3BFerrier-Auerbach%2C+Amanda+G%3BMeis%2C+Laura+A%3BArbisi%2C+Paul+A%3BErbes%2C+Christopher+R%3BPolusny%2C+Melissa+A&rft.aulast=Kehle&rft.aufirst=Shannon&rft.date=2012-03-01&rft.volume=26&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/10.1037%2Fa0024663 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PABEEI N1 - SubjectsTermNotLitGenreText - Soldiers; Posttraumatic stress disorder; Deployment; Symptoms; Freedom; Emotionality DO - http://dx.doi.org/10.1037/a0024663 ER - TY - JOUR T1 - Drinking refusal self-efficacy and tension-reduction alcohol expectancies moderating the relationship between generalized anxiety and drinking behaviors in young adult drinkers. AN - 1449097939; 201323503 AB - Despite the substantial comorbidity between generalized anxiety disorder (GAD) and alcohol use disorders (AUD), little is known about contributing factors to this relationship. This lack of knowledge has limited the development of theoretical models explicating the interesting yet complex relationship between GAD and AUD. The current study examined the roles of generalized anxiety, tension-reduction alcohol expectancies, and drinking refusal self-efficacy in accounting for the variance of alcohol consumption and alcohol-related consequences in a sample of young adult drinkers (N = 474; 18-25 years of age, median age 19, 66% female) from a large, urban Midwestern university. Results showed that generalized anxiety level interacted with both tension-reduction alcohol expectancies and drinking refusal self-efficacy to predict alcohol consumption and alcohol-related consequences. Findings support the assessment of both alcohol-related consequences and alcohol consumption, and highlight the importance of drinking refusal self-efficacy, which is a currently underexamined variable. Study results also enhance the knowledge about the underlining mechanisms of GAD and AUD comorbidity, which facilitates the development of an empirically based theoretical paradigm for their relationship. [Copyright The American Psychological Association.] JF - Psychology of Addictive Behaviors AU - Goldsmith, Abigail A AU - Thompson, Rachel D AU - Black, Jessica J AU - Tran, Giao Q AU - Smith, Joshua P AD - Department of Psychology, University of Cincinnati abigail.goldsmith@va.gov Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 59 EP - 67 PB - American Psychological Association, Washington DC VL - 26 IS - 1 SN - 0893-164X, 0893-164X KW - alcohol expectancies KW - alcohol problems KW - alcohol use KW - drinking refusal self-efficacy KW - generalized anxiety disorder KW - tension reduction KW - young adults KW - Selfefficacy KW - Alcohol consumption KW - Alcohol related expectations KW - Generalized anxiety disorders KW - Alcohol related problems KW - Refusal KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1449097939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Addictive+Behaviors&rft.atitle=Drinking+refusal+self-efficacy+and+tension-reduction+alcohol+expectancies+moderating+the+relationship+between+generalized+anxiety+and+drinking+behaviors+in+young+adult+drinkers.&rft.au=Goldsmith%2C+Abigail+A%3BThompson%2C+Rachel+D%3BBlack%2C+Jessica+J%3BTran%2C+Giao+Q%3BSmith%2C+Joshua+P&rft.aulast=Goldsmith&rft.aufirst=Abigail&rft.date=2012-03-01&rft.volume=26&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/10.1037%2Fa0024766 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PABEEI N1 - SubjectsTermNotLitGenreText - Alcohol consumption; Generalized anxiety disorders; Selfefficacy; Refusal; Alcohol related expectations; Alcohol related problems DO - http://dx.doi.org/10.1037/a0024766 ER - TY - JOUR T1 - Rates and Correlates of Pathological Gambling Among VA Mental Health Service Users AN - 1266173383; 201300163 AB - The rate and correlates of diagnosed pathological gambling (PG) among mental health patients in the Veterans Health Administration, the only national system of mental health care, have not been studied. Using fiscal year 2009 (FY2009) VA administrative data, a case-control study compared those with an ICD code of 312.31 (PG) versus those without. The analytic group was limited to 1,102,846 Veterans Affairs (VA) specialty mental health (MH) services users because 94.5% of all those diagnosed with PG in the U.S. VA health system received such services. Chi-square tests and logistic regression assessed associations between demographic and clinical factors and PG diagnosis. The past-year rate of PG diagnosis among veterans treated in specialty MH program was 0.2%, significantly lower than prevalence rates in other treatment samples and the general U.S population, suggesting under-diagnosis and/or a low-income sample. Being female, ages 40-74, and higher income increased the risk of PG diagnosis, as did past-year homelessness (Odds Ratio (OR) = 2.2), alcohol use disorders (OR = 2.8), bipolar disorder (OR = 2.1) and personality disorders (OR = 2.1). Depression, schizophrenia, and anxiety disorders other than PTSD, were also positively associated with PG diagnosis. Drug use disorder had no significant independent association with PG. PTSD, dementia, and living in isolated rural areas conferred reduced risk. More systematic screening and surveillance of PG among MH service users generally, and veterans with heavy alcohol use, severe mental illness, and homelessness specifically, appears warranted. Adapted from the source document. JF - Journal of Gambling Studies AU - Edens, Ellen L AU - Rosenheck, Robert A AD - VA New England Mental Illness Research, Education, and Clinical Center (MIRECC), West Haven, CT, USA ellen.edens@va.gov Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 1 EP - 11 PB - Springer, New York NY VL - 28 IS - 1 SN - 1050-5350, 1050-5350 KW - Veterans KW - Pathological gambling KW - Mentally ill people KW - Posttraumatic stress disorder KW - Diagnosis KW - Anxiety-Depression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266173383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gambling+Studies&rft.atitle=Rates+and+Correlates+of+Pathological+Gambling+Among+VA+Mental+Health+Service+Users&rft.au=Edens%2C+Ellen+L%3BRosenheck%2C+Robert+A&rft.aulast=Edens&rft.aufirst=Ellen&rft.date=2012-03-01&rft.volume=28&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gambling+Studies&rft.issn=10505350&rft_id=info:doi/10.1007%2Fs10899-011-9239-z LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-01-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JGSTEM N1 - SubjectsTermNotLitGenreText - Diagnosis; Mentally ill people; Veterans; Posttraumatic stress disorder; Anxiety-Depression; Pathological gambling DO - http://dx.doi.org/10.1007/s10899-011-9239-z ER - TY - JOUR T1 - Subchronic Jp-8 Jet Fuel Exposure Enhances Vulnerability To Noise-Induced Hearing Loss In Rats AN - 1257788673; 17487710 AB - Both laboratory and epidemiological studies published over the past two decades have identified the risk of excess hearing loss when specific chemical contaminants are present along with noise. The objective of this study was to evaluate the potency of JP-8 jet fuel to enhance noise-induced hearing loss (NIHL) using inhalation exposure to fuel and simultaneous exposure to either continuous or intermittent noise exposure over a 4-wk exposure period using both male and female Fischer 344 rats. In the initial study, male (n = 5) and female (n = 5) rats received inhalation exposure to JP-8 fuel for 6 h/d, 5 d/wk for 4 wk at concentrations of 200, 750, or 1500 mg/m super(3). Parallel groups of rats also received nondamaging noise (constant octave band noise at 85 dB sub(lin)) in combination with the fuel, noise alone (75, 85, or 95 dB), or no exposure to fuel or noise. Significant concentration-related impairment of auditory function measured by distortion product otoacoustic emissions (DPOAE) and compound action potential (CAP) threshold was seen in rats exposed to combined JP-8 plus noise exposure when JP-8 levels of 1500 mg/m super(3) were presented with trends toward impairment seen with 750 mg/m super(3) JP-8 + noise. JP-8 alone exerted no significant effect on auditory function. In addition, noise was able to disrupt the DPOAE and increase auditory thresholds only when noise exposure was at 95 dB. In a subsequent study, male (n = 5 per group) and female (n = 5 per group) rats received 1000 mg/m super(3) JP-8 for 6 h/d, 5 d/wk for 4 wk with and without exposure to 102 dB octave band noise that was present for 15 min out of each hour (total noise duration 90 min). Comparisons were made to rats receiving only noise, and thosereceiving no experimental treatment. Significant impairment of auditory thresholds especially for high-frequency tones was identified in the male rats receiving combined treatment. This study provides a basis for estimating excessive hearing loss under conditions of subchronic JP-8 jet fuel exposure. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Fechter, L D AU - Fisher, J W AU - Chapman, G D AU - Mokashi, V P AU - Ortiz, P A AU - Reboulet, JE AU - Stubbs, JE AU - Lear, A M AU - McInturf, S M AU - Prues, S L AU - Gearhart, CA AU - Fulton, S AU - Mattie AD - Jerry Pettis Memorial VA Medical Center, Loma Linda, California, USA, larry.fechter@va.gov Y1 - 2012/03/01/ PY - 2012 DA - 2012 Mar 01 SP - 299 EP - 317 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 75 IS - 5 SN - 1528-7394, 1528-7394 KW - Environment Abstracts; Toxicology Abstracts KW - Inhalation KW - otoacoustic emissions KW - Auditory system KW - Fuels KW - Noise levels KW - Hearing loss KW - Rats KW - Action potential KW - Noise KW - Chemical pollution KW - Vulnerability KW - Contaminants KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1257788673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Subchronic+Jp-8+Jet+Fuel+Exposure+Enhances+Vulnerability+To+Noise-Induced+Hearing+Loss+In+Rats&rft.au=Fechter%2C+L+D%3BFisher%2C+J+W%3BChapman%2C+G+D%3BMokashi%2C+V+P%3BOrtiz%2C+P+A%3BReboulet%2C+JE%3BStubbs%2C+JE%3BLear%2C+A+M%3BMcInturf%2C+S+M%3BPrues%2C+S+L%3BGearhart%2C+CA%3BFulton%2C+S%3BMattie&rft.aulast=Fechter&rft.aufirst=L&rft.date=2012-03-01&rft.volume=75&rft.issue=5&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2012.652060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Inhalation; otoacoustic emissions; Action potential; Auditory system; Fuels; Noise; Hearing loss; Contaminants; Rats; Noise levels; Vulnerability; Chemical pollution DO - http://dx.doi.org/10.1080/15287394.2012.652060 ER - TY - JOUR T1 - Post-traumatic stress disorder is associated with poor health behaviors: Findings from the Heart and Soul Study. AN - 1125286024; 201227950 AB - Objective: Posttraumatic stress disorder (PTSD) results in substantial disability, including increased risk of cardiovascular disease (CVD). Poor health behaviors are major risk factors for initial and recurrent CVD events. Therefore, this study investigated whether PTSD is associated with poor health behaviors in patients with CVD. Method: Cross-sectional study of 1,022 men and women with CVD. PTSD was assessed with the Computerized Diagnostic Interview Schedule for DSM-IV. Physical activity, medication adherence and smoking history were determined by self-report questionnaires. Multivariate logistic and linear regression models were used to evaluate the association of PTSD with health behaviors. Results: Of the 1,022 participants, 95 (9%) had PTSD. PTSD was associated with significantly higher rates of physical inactivity in terms of overall exercise (OR 1.6, 95% CI [1.0-2.6]; p = .049), light exercise (OR 1.7, 95% CI [1.0-2.9]; p = .045), and self-rated level of exercise compared to others of their age and sex (OR 1.8, 95% CI [1.0-3.0]; p = .047). Participants with PTSD were more likely to report medication nonadherence, including forgetting medications (OR 1.8, 95% CI [1.0-3.3]; p = .04) or skipping medications (OR 1.7, 95% CI [1.1-2.9]; p = .03). Participants with PTSD also reported a greater smoking history (Beta 6.4 pack years, 95% CI [1.8-10.9]; p = .006), which remained significant after adjustment for depression and income. Conclusions: Among patients with heart disease, those with PTSD were more likely to report physical inactivity, medication nonadherence and smoking. The majority of these associations were explained by adjustment for comorbid depression and lower income. [Copyright The American Psychological Association.] JF - Health Psychology AU - Zen, Angelica L AU - Whooley, Mary A AU - Zhao, Shoujun AU - Cohen, Beth E AD - Department of Veterans Affairs Medical Center, Section of General Internal Medicine, San Francisco, CA, US Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 194 EP - 201 PB - American Psychological Association, Washington DC VL - 31 IS - 2 SN - 0278-6133, 0278-6133 KW - health behaviors KW - medication adherence KW - physical activity KW - posttraumatic stress disorder KW - smoking KW - cardiovascular disease KW - Smoking KW - Posttraumatic stress disorder KW - Physical activity KW - Adherence KW - Exercise KW - Cardiovascular diseases KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125286024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Psychology&rft.atitle=Post-traumatic+stress+disorder+is+associated+with+poor+health+behaviors%3A+Findings+from+the+Heart+and+Soul+Study.&rft.au=Zen%2C+Angelica+L%3BWhooley%2C+Mary+A%3BZhao%2C+Shoujun%3BCohen%2C+Beth+E&rft.aulast=Zen&rft.aufirst=Angelica&rft.date=2012-03-01&rft.volume=31&rft.issue=2&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2Fa0025989 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Cardiovascular diseases; Exercise; Physical activity; Adherence; Smoking DO - http://dx.doi.org/10.1037/a0025989 ER - TY - JOUR T1 - From personal tragedy to personal challenge: responses to stigma among sober living home residents and operators AN - 1038899912; 4331750 AB - Sober living homes for people attempting to maintain abstinence from alcohol and drugs can act as a buffer against the high rates of substance misuse that are endemic to many urban environments. Sober living homes and other group homes for people with disabilities have faced persistent opposition from neighbourhood associations, which raises the question of stigma. This article describes the responses of sober living home residents and operators to the threat of stigma across a diverse set of neighbourhoods. Ten focus groups were conducted with 68 residents and operators of 35 sober living homes in Los Angeles County, California, between January 2009 and March 2010. Results showed that few residents reported experiences of blatant stigmatisation by neighbours; however, they were well aware of the stereotypes that could be ascribed to them. Despite this potential stigma, residents developed valued identities as helpers in their communities, providing advice to neighbours whose family or friends had substance use problems, and organising community service activities to improve the appearance of their neighbourhoods. With their attention to local context, sober living home residents and operators challenge the personal tragedy approach of much traditional advocacy on health-related stigma. Reprinted by permission of Blackwell Publishers JF - Sociology of health and illness AU - Heslin, Kevin C AU - Singzon, Trudy AU - Aimiuwu, Otaren AU - Sheridan, Dave AU - Hamilton, Alison AD - Veterans Health Administration, Sepulveda ; San Francisco Department of Public Health ; Charles Drew University ; Sober Living Network, Los Angeles ; University of California, Los Angeles Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 379 EP - 395 VL - 34 IS - 3 SN - 0141-9889, 0141-9889 KW - Sociology KW - Alcohol KW - Disabled persons KW - Advocacy KW - Associations KW - Neighbourhoods KW - Neighbouring relationships KW - U.S.A. KW - Drugs KW - Stigma KW - Tragedy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038899912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sociology+of+health+and+illness&rft.atitle=From+personal+tragedy+to+personal+challenge%3A+responses+to+stigma+among+sober+living+home+residents+and+operators&rft.au=Heslin%2C+Kevin+C%3BSingzon%2C+Trudy%3BAimiuwu%2C+Otaren%3BSheridan%2C+Dave%3BHamilton%2C+Alison&rft.aulast=Heslin&rft.aufirst=Kevin&rft.date=2012-03-01&rft.volume=34&rft.issue=3&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Sociology+of+health+and+illness&rft.issn=01419889&rft_id=info:doi/10.1111%2Fj.1467-9566.2011.01376.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12892; 12258 11762 11859 11856; 909; 3755; 3590; 8607; 1353 9030; 8609 6093; 611 656; 433 293 14 DO - http://dx.doi.org/10.1111/j.1467-9566.2011.01376.x ER - TY - JOUR T1 - Postscript AN - 1023095168; 201215790 AB - The case presenter provides some follow-up information regarding the case of Ms. T, as well as some final comments and reactions to the commentaries and discussion by the expert reviewers. The article is part of a 'clinical exchange' in the journal issue, in which clinicians share formulations and treatment plans of the same psychotherapy patient and then discuss points of convergence and contention in their recommendations. [Copyright The American Psychological Association.] JF - Journal of Psychotherapy Integration AU - Kores, Robert C AD - Department of Psychiatry, University of Tennessee Health Science Center robert.kores@va.gov Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 47 EP - 61 PB - American Psychological Association, Washington DC VL - 22 IS - 1 SN - 1053-0479, 1053-0479 KW - case formulation KW - psychotherapy KW - psychotherapy integration KW - somatization KW - Psychotherapy KW - Treatment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023095168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychotherapy+Integration&rft.atitle=Postscript&rft.au=Kores%2C+Robert+C&rft.aulast=Kores&rft.aufirst=Robert&rft.date=2012-03-01&rft.volume=22&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychotherapy+Integration&rft.issn=10530479&rft_id=info:doi/10.1037%2Fa0027323 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JPINEH N1 - SubjectsTermNotLitGenreText - Psychotherapy; Treatment DO - http://dx.doi.org/10.1037/a0027323 ER - TY - JOUR T1 - Chronic conversion disorder masking depression and anxiety: The case of Ms. T. AN - 1023095165; 201215789 AB - A case formulation with therapeutic focus and direction, and follow-up information regarding a geriatric patient with somatic concerns is presented. A conversion disorder was diagnosed with underlying depression and anxiety. A lack of secure attachment and a nurturing environment were core issues. Family of origin suppressed feelings and choices, was rigid and hypercritical, and rejecting and abusive. An integrated therapy model addressed these identified issues through relationship development, behavioral activation, affect regulation and efforts to replace maladaptive schemas with more adaptive cognitions and behaviors. The article is part of a 'clinical exchange' in the journal issue, in which clinicians share formulations and treatment plans of the same psychotherapy patient and then discuss points of convergence and contention in their recommendations. [Copyright The American Psychological Association.] JF - Journal of Psychotherapy Integration AU - Kores, Robert C AD - Department of Psychiatry, University of Tennessee Health Science Center robert.kores@va.gov Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 7 EP - 13 PB - American Psychological Association, Washington DC VL - 22 IS - 1 SN - 1053-0479, 1053-0479 KW - case formulation KW - psychotherapy KW - psychotherapy integration KW - somatization KW - chronic conversion disorder KW - depression KW - anxiety KW - geriatric patient KW - Suppressed KW - Maladaptive behaviour KW - Conversion disorder KW - Case formulation KW - Social development KW - Anxiety-Depression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023095165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychotherapy+Integration&rft.atitle=Chronic+conversion+disorder+masking+depression+and+anxiety%3A+The+case+of+Ms.+T.&rft.au=Kores%2C+Robert+C&rft.aulast=Kores&rft.aufirst=Robert&rft.date=2012-03-01&rft.volume=22&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychotherapy+Integration&rft.issn=10530479&rft_id=info:doi/10.1037%2Fa0027318 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JPINEH N1 - SubjectsTermNotLitGenreText - Anxiety-Depression; Conversion disorder; Suppressed; Maladaptive behaviour; Social development; Case formulation DO - http://dx.doi.org/10.1037/a0027318 ER - TY - JOUR T1 - Anger, dissociation, and PTSD among male veterans entering into PTSD treatment AN - 1023091415; 201215863 AB - Prior research suggests that dissociation and anger are risk factors for the development of posttraumatic stress disorder (PTSD). Research found that trauma survivors with higher levels of anger also report more severe PTSD overall. Studies also support a relationship between PTSD severity and dissociation. Only one prior study of sexual assault survivors by Feeny, Zoellner, and Foa (2000) examined the relationships among dissociation, anger, and PTSD. While Veterans have been found to report high levels of anger and dissociation, the relationship between these factors and PTSD has not been examined among Veterans. This paper examines the relationship among anger, dissociation, and PTSD in treatment-seeking Veterans who presented for evaluation at the PTSD Clinic in the VA Ann Arbor Healthcare System during a four year period. Anger and dissociation predicted PTSD, hyperarousal, and avoidance/numbing severity while dissociation predicted intrusive severity. The implications of these results for clinical practice are discussed. [Copyright Elsevier B.V.] JF - Journal of Anxiety Disorders AU - Kulkarni, Madhur AU - Porter, Katherine E AU - Rauch, Sheila A M Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 271 EP - 278 PB - Elsevier Ltd, The Netherlands VL - 26 IS - 2 SN - 0887-6185, 0887-6185 KW - Anger KW - PTSD KW - Dissociation KW - Veterans KW - Severity KW - Posttraumatic stress disorder KW - Survivors KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023091415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Anxiety+Disorders&rft.atitle=Anger%2C+dissociation%2C+and+PTSD+among+male+veterans+entering+into+PTSD+treatment&rft.au=Kulkarni%2C+Madhur%3BPorter%2C+Katherine+E%3BRauch%2C+Sheila+A+M&rft.aulast=Kulkarni&rft.aufirst=Madhur&rft.date=2012-03-01&rft.volume=26&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Journal+of+Anxiety+Disorders&rft.issn=08876185&rft_id=info:doi/10.1016%2Fj.janxdis.2011.12.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Dissociation; Anger; Veterans; Severity; Survivors DO - http://dx.doi.org/10.1016/j.janxdis.2011.12.005 ER - TY - JOUR T1 - Treatment Outcome for Flexible Dosing Buprenorphine Maintenance Treatment AN - 1018354777; 201214376 AB - Background and objectives: Achieving the best treatment outcome with the least cost should be the goal for buprenorphine office-based treatment. Methods: We conducted an observational retrospective chart review to compare the treatment outcome for patients (n = 56) receiving high dose of buprenorphine (above 16 mg daily) and patients (n = 21) receiving moderate doses (8-16 mg daily). Results: The percentages of the first four urine drug screens (UDS) positive for opiates were significantly higher for the high-dose group than for the moderate-dose group (F = 7.93, df = 7, p < .0001). However, the percentages of the most recent four UDS positive for opiates were not statistically significant (F = .62, df = 7, p = .74). The difference in the percentages of the first and last UDS for the high-dose group showed significant reduction from admission to most recently but there was no significant difference for the moderate-dose group (t = 3.1, df = 105, p = .002 for the high-dose group and t = 1.1, df = 40, p = .27 for the moderate-dose group). Conclusions and scientific significance: Using flexible buprenorphine dosing schedule with the option of titrating the dose up to 32 mg daily may offer better treatment outcome for patients who would not respond to the lower dose range. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Fareed, Ayman AU - Vayalapalli, Sreedevi AU - Casarella, Jennifer AU - Drexler, Karen AD - Department of Psychiatry, Emory University School of Medicine/Atlanta VA Medical Center ayman.fareed@va.gov Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 155 EP - 160 PB - Taylor & Francis Inc., Philadelphia, PA VL - 38 IS - 2 SN - 0095-2990, 0095-2990 KW - buprenorphine, flexible, dosing, outcome KW - Treatment Outcomes KW - Opiates KW - Patients KW - Graphs KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018354777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Treatment+Outcome+for+Flexible+Dosing+Buprenorphine+Maintenance+Treatment&rft.au=Fareed%2C+Ayman%3BVayalapalli%2C+Sreedevi%3BCasarella%2C+Jennifer%3BDrexler%2C+Karen&rft.aulast=Fareed&rft.aufirst=Ayman&rft.date=2012-03-01&rft.volume=38&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.3109%2F00952990.2011.643988 LA - English DB - Sociological Abstracts N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Treatment Outcomes; Patients; Opiates; Graphs DO - http://dx.doi.org/10.3109/00952990.2011.643988 ER - TY - JOUR T1 - Ethical Issues: Putting the Meds in the Applesauce AN - 1010709040; 201209192 AB - Is hiding medicine in food ever ethically justified? Adapted from the source document. JF - American Journal of Nursing AU - Olsen, Douglas P AD - National Center for Ethics in Health Care, Veterans Health Administration and Uniformed Services University of the Health Sciences empmat@gmail.com Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 67 EP - 69 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 112 IS - 3 SN - 0002-936X, 0002-936X KW - Ethical dilemmas KW - Food KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010709040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Nursing&rft.atitle=Ethical+Issues%3A+Putting+the+Meds+in+the+Applesauce&rft.au=Olsen%2C+Douglas+P&rft.aulast=Olsen&rft.aufirst=Douglas&rft.date=2012-03-01&rft.volume=112&rft.issue=3&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Nursing&rft.issn=0002936X&rft_id=info:doi/10.1097%2F01.NAJ.0000412642.93516.42 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Food; Ethical dilemmas DO - http://dx.doi.org/10.1097/01.NAJ.0000412642.93516.42 ER - TY - JOUR T1 - The Words-in-Noise Test (WIN), list 3: a practice list. AN - 963837059; pmid-22353677 AB - The Words-in-Noise Test (WIN) was developed as an instrument to quantify the ability of listeners to understand monosyllabic words in background noise using multitalker babble (Wilson, 2003). The 50% point, which is calculated with the Spearman-Kärber equation (Finney, 1952), is used as the evaluative metric with the WIN materials. Initially, the WIN was designed as a 70-word instrument that presented ten unique words at each of seven signal-to-noise ratios from 24 to 0 dB in 4 dB decrements. Subsequently, the 70-word list was parsed into two 35-word lists that achieved equivalent recognition performances (Wilson and Burks, 2005). This report involves the development of a third list (WIN List 3) that was developed to serve as a practice list to familiarize the participant with listening to words presented in background babble.To determine-on young listeners with normal hearing and on older listeners with sensorineural hearing loss-the psychometric properties of the WIN List 3 materials.A quasi-experimental, repeated-measures design was used.Twenty-four young adult listeners (M = 21.6 yr) with normal pure-tone thresholds (≤ 20 dB HL at 250 to 8000 Hz) and 24 older listeners (M = 65.9 yr) with sensorineural hearing loss participated.The level of the babble was fixed at 80 dB SPL with the level of the words varied from 104 to 80 dB SPL in 4 dB decrements.For listeners with normal hearing, the 50% points for Lists 1 and 2 were similar (4.3 and 5.1 dB S/N, respectively), both of which were lower than the 50% point for List 3 (7.4 dB S/N). A similar relation was observed with the listeners with hearing loss, 50% points for Lists 1 and 2 of 12.2 and 12.4 dB S/N, respectively, compared to 15.8 dB S/N for List 3. The differences between Lists 1 and 2 and List 3 were significant. The relations among the psychometric functions and the relations among the individual data both reflected these differences.The significant ∼3 dB difference between performances on WIN Lists 1 and 2 and on WIN List 3 by the listeners with normal hearing and the listeners with hearing loss dictates caution with the use of List 3. The use of WIN List 3 should be reserved for ancillary purposes in which equivalent recognition performances are not required, for example, as a practice list or a stand alone measure.American Academy of Audiology. JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AU - Watts, Kelly L AD - James H. Quillen VA Medical Center, Mountain Home, TN, USA. richard.wilson2@va.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 92 EP - 96 VL - 23 IS - 2 SN - 1050-0545, 1050-0545 KW - National Library of Medicine KW - Adolescent KW - Aged KW - Audiometry, Pure-Tone KW - Auditory Threshold KW - *Hearing Loss, Sensorineural: diagnosis KW - *Hearing Loss, Sensorineural: physiopathology KW - Hearing Loss, Sensorineural: psychology KW - Hearing Tests: methods KW - Humans KW - Middle Aged KW - Noise KW - Protozoan Proteins KW - *Psychoacoustics KW - *Psychometrics KW - *Speech Perception KW - Young Adult UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/963837059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=The+Words-in-Noise+Test+%28WIN%29%2C+list+3%3A+a+practice+list.&rft.au=Wilson%2C+Richard+H%3BWatts%2C+Kelly+L&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2012-02-01&rft.volume=23&rft.issue=2&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2012-04-26 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Personality-based latent classes of posttraumatic psychopathology: Personality disorders and the internalizing/externalizing model AN - 1512191882; 201407659 AB - Prior research using the Brief Form of the Multidimensional Personality Questionnaire (MPQ-BF; Patrick, Curtin, & Tellegen, 2002) has shown evidence of 3 temperament-based subtypes -- termed internalizing, externalizing, and simple PTSD -- among individuals with symptoms of posttraumatic stress disorder (PTSD; Miller, Greif, & Smith, 2003). This study sought to replicate and extend research in this area by conducting a latent profile analysis of higher order temperament scales from the MPQ-BF using a new sample of 208 veterans with symptoms of PTSD. Results suggest that a 3-class solution reflecting internalizing, externalizing, and simple subtypes of posttraumatic psychopathology provided the best fit to the data. The externalizing subtype was characterized by features of antisocial, borderline, histrionic, and narcissistic personality disorders on the International Personality Disorder Examination (Loranger, 1999) as well as low levels of constraint and high levels of negative emotionality on the MPQ-BF. In contrast, individuals in the internalizing class exhibited features of schizoid and avoidant personality disorders, low levels of positive emotionality, and high levels of negative emotionality. The simple subtype was defined by low levels of comorbid personality disorder features and relatively normal personality profiles. Findings support the reliability of this typology and support the relevance of the internalizing and externalizing model to the structure of personality disorders. [Copyright American Psychological Association] JF - Journal of Abnormal Psychology AU - Wolf, Erika J AU - Miller, Mark W AU - Harrington, Kelly M AU - Reardon, Annemarie AD - National Center for PTSD, Boston, MA, USA Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 256 EP - 262 PB - American Psychological Association, Washington DC VL - 121 IS - 1 SN - 0021-843X, 0021-843X KW - PTSD KW - externalizing KW - internalizing KW - latent profile analysis KW - personality disorders KW - posttraumatic stress disorder KW - Posttraumatic stress disorder KW - Subtypes KW - Internalization KW - Externalizing behaviour KW - Emotionality KW - Personality disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1512191882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Psychology&rft.atitle=Personality-based+latent+classes+of+posttraumatic+psychopathology%3A+Personality+disorders+and+the+internalizing%2Fexternalizing+model&rft.au=Wolf%2C+Erika+J%3BMiller%2C+Mark+W%3BHarrington%2C+Kelly+M%3BReardon%2C+Annemarie&rft.aulast=Wolf&rft.aufirst=Erika&rft.date=2012-02-01&rft.volume=121&rft.issue=1&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Psychology&rft.issn=0021843X&rft_id=info:doi/10.1037%2Fa0023237 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JABCAA N1 - SubjectsTermNotLitGenreText - Internalization; Externalizing behaviour; Subtypes; Posttraumatic stress disorder; Personality disorders; Emotionality DO - http://dx.doi.org/10.1037/a0023237 ER - TY - JOUR T1 - Impact of a Multicomponent Support Services Program on Informal Caregivers of Adults Aging With Disabilities AN - 1438554210; 201308164 AB - A multicomponent support services program was implemented for veterans aging with disabilities and their informal caregivers (n = 42 dyads). Caregiver outcomes (satisfaction, physical and mental health status, burden, and benefits) were evaluated before and after program use. Caregivers reported significant improvements in mental health post-program. Caregivers who provided care to individuals with impaired physical health experienced meaningful improvements in burden after the support services were rendered. Supporting caregiver health status through such programs is vital to preserve noninstitutional long-term care for persons aging with disabilities, particularly when care is provided over many years to an individual with physical impairments. Adapted from the source document. JF - Journal of Gerontological Social Work AU - LaVela, Sherri L AU - Johnson, Brenda W AU - Miskevics, Scott AU - Weaver, Frances M AD - Center for Management of Complex Chronic Care, Hines Veterans Affairs Hospital, Hines, Illinois, USA sherri.lavela@va.gov Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 160 EP - 174 PB - Taylor & Francis, Philadelphia PA VL - 55 IS - 2 SN - 0163-4372, 0163-4372 KW - caregiving long-term care chronic illness KW - Veterans KW - Handicapped KW - Caregivers KW - Physically Handicapped KW - Satisfaction KW - Health Problems KW - Aging KW - Mental Health KW - Health Care Services KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438554210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gerontological+Social+Work&rft.atitle=Impact+of+a+Multicomponent+Support+Services+Program+on+Informal+Caregivers+of+Adults+Aging+With+Disabilities&rft.au=LaVela%2C+Sherri+L%3BJohnson%2C+Brenda+W%3BMiskevics%2C+Scott%3BWeaver%2C+Frances+M&rft.aulast=LaVela&rft.aufirst=Sherri&rft.date=2012-02-01&rft.volume=55&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gerontological+Social+Work&rft.issn=01634372&rft_id=info:doi/10.1080%2F01634372.2011.642472 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JGSWDU N1 - SubjectsTermNotLitGenreText - Caregivers; Physically Handicapped; Aging; Mental Health; Satisfaction; Health Care Services; Handicapped; Health Problems; Veterans DO - http://dx.doi.org/10.1080/01634372.2011.642472 ER - TY - JOUR T1 - Use and Quality of Care at a VA Outreach Clinic in Northern Maine AN - 1373490716; 201313534 AB - Objective: To assess use and quality of care at a new 1-day-per-week Veterans Administration Outreach Clinic in remote northern Maine. Methods: Veterans Administration electronic medical records were abstracted to compare outreach clinic patients seen in its first year to patients seen at the nearest outpatient treatment sites, a small-staff, full-time VA clinic 81 miles away and a community-based outpatient clinic 55 miles away. Chart abstractions (N = 1251) yielded counts of visits, patients newly enrolled in VA care, patients transferring to the outreach clinic, and patients who had and maintained a local non-VA primary care physician, as well as multiple quality of care performance measures using standard VA criteria. Results: The outreach clinic enrolled very few patients new to VA; 96% of its patients were transfers from other sites. For transfers, the average one-way driving burden to reach primary care was reduced by 52.9 miles and 58.1 minutes to reach. Compared to community-based outpatient clinic patients, outreach clinic patients were more likely to have three or more provider visits during the year. Some quality of care measures were lower at the outreach clinic: obesity screenings, referrals to smoking cessation services, diabetes management, and hypertension control. At all three sites, most patients had health insurance coverage and kept a local, non-VA doctor throughout the year. Conclusions: A part-time outreach clinic improved the convenience of primary care for rural VA outpatients, though quality of care was reduced for some measures related to equipment and staffing limitations. Most patients at any VA site had a local, non-VA medical doctor with whom they remained in care while using VA services. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Journal of Primary Care & Community Health AU - Lee, Pamela W AU - Markle, Penelope S AU - West, Alan N AU - Lee, Richard E AD - Veterans Rural Health Resource Center-Eastern Region, VA Medical Center (10A5A), White River Junction, VT, USA pamela.lee@va.gov Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 159 EP - 163 PB - Sage Publications, Thousand Oaks CA VL - 3 IS - 3 SN - 2150-1319, 2150-1319 KW - veteran's rural, access, primary care, quality of care KW - Quality of care KW - Doctors KW - Primary health care KW - Community based KW - Outreach clinics KW - Military hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1373490716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Primary+Care+%26+Community+Health&rft.atitle=Use+and+Quality+of+Care+at+a+VA+Outreach+Clinic+in+Northern+Maine&rft.au=Lee%2C+Pamela+W%3BMarkle%2C+Penelope+S%3BWest%2C+Alan+N%3BLee%2C+Richard+E&rft.aulast=Lee&rft.aufirst=Pamela&rft.date=2012-02-01&rft.volume=3&rft.issue=3&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Journal+of+Primary+Care+%26+Community+Health&rft.issn=21501319&rft_id=info:doi/10.1177%2F2150131911427167 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Outreach clinics; Quality of care; Doctors; Primary health care; Military hospitals; Community based DO - http://dx.doi.org/10.1177/2150131911427167 ER - TY - JOUR T1 - Emerging opportunities for psychologists: Joining consumers in the recovery-oriented care movement AN - 1023092432; 201213553 AB - A transformation is occurring in mental health services throughout the country that presents opportunities for both seasoned and aspiring psychologists. This paper draws on the experiences of (a) a VA staff psychologist, (b) a psychology postdoctoral fellow, (c) a director of clinical training (and clinical-community psychologist) at an APA-accredited doctoral training program, and (d) a psychologist who leads the Psychosocial Rehabilitation and Recovery Section of the Department of Veterans Affairs' Office of Mental Health Services. We illustrate: (1) Opportunities for psychologists that exist within recovery-oriented systems; (2) How psychologists' skills and training put them in a unique position to be leaders within mental health recovery-oriented systems of care; and (3) Specific recommendations for psychologists to prepare them for roles in a recovery-oriented system of care. We believe that a new dawn has arrived, and interested psychologists are well-suited to be key agents of change and leaders in emerging best practices in mental health care. [Copyright Elsevier B.V.] JF - Professional Psychology: Research and Practice AU - Cohen, Jay L AU - Abraham, Kristen M AU - Burk, Jeffrey P AU - Stein, Catherine H AD - John D. Dingell Veterans Affairs Medical Center jay.cohen@va.gov Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 24 EP - 31 PB - American Psychological Association, Washington DC VL - 43 IS - 1 SN - 0735-7028, 0735-7028 KW - community psychology KW - professional practice KW - recovery KW - systems transformation KW - veterans KW - veterans affairs KW - Change agents KW - Mental health services KW - Psychologists KW - Leaders KW - Psychosocial rehabilitation KW - Clinical psychologists KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023092432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Psychology%3A+Research+and+Practice&rft.atitle=Emerging+opportunities+for+psychologists%3A+Joining+consumers+in+the+recovery-oriented+care+movement&rft.au=Cohen%2C+Jay+L%3BAbraham%2C+Kristen+M%3BBurk%2C+Jeffrey+P%3BStein%2C+Catherine+H&rft.aulast=Cohen&rft.aufirst=Jay&rft.date=2012-02-01&rft.volume=43&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Professional+Psychology%3A+Research+and+Practice&rft.issn=07357028&rft_id=info:doi/10.1037%2Fa0024394 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Psychologists; Clinical psychologists; Mental health services; Leaders; Psychosocial rehabilitation; Change agents DO - http://dx.doi.org/10.1037/a0024394 ER - TY - JOUR T1 - Multivariate DPOAE metrics for identifying changes in hearing: Perspectives from ototoxicity monitoring AN - 1018376054; 201211064 AB - Distortion-product otoacoustic emissions (DPOAEs) provide a window into real-time cochlear mechanical function. Yet, relationships between the changes in DPOAE metrics and auditory sensitivity are still poorly understood. Explicating these relationships might support the use of DPOAEs in hearing conservation programs (HCPs) for detecting early damage leading to noise-induced hearing loss (NIHL) so that mitigating steps might be taken to limit any lasting damage. This report describes the development of DPOAE-based statistical models to assess the risk of hearing loss from cisplatin treatment among cancer patients. Ototoxicity risk assessment (ORA) models were constructed using a machine learning paradigm in which partial least squares and leave-one-out cross-validation were applied, yielding optimal screening algorithms from a set of known risk factors for ototoxicity and DPOAE changes from pre-exposure baseline measures. Single DPOAE metrics alone were poorer indicators of the risk of ototoxic hearing shifts than the best performing multivariate models. This finding suggests that multivariate approaches applied to the use of DPOAEs in a HCP, will improve the ability of DPOAE measures to identify ears with noise-induced mechanical damage and/or hearing loss at each monitoring interval. This prediction must be empirically assessed in noise-exposed subjects. Adapted from the source document. JF - International Journal of Audiology AU - Konrad-Martin, Dawn AU - Reavis, Kelly M AU - Mcmillan, Garnett P AU - Dille, Marilyn F AD - National Center for Rehabilitative Auditory Research (NCRAR), Portland VA Medical Center dawn.martin@va.gov Y1 - 2012/02// PY - 2012 DA - February 2012 SP - s51 EP - s62 PB - Informa Healthcare, Taylor and Francis, London UK VL - 51 IS - supplement 1 SN - 1499-2027, 1499-2027 KW - Otoacoustic emission, noise-induced hearing loss, ototoxicity monitoring KW - Risk assessment KW - Learning KW - Ears KW - Hearing KW - Hearing impairment KW - Models KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018376054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=Multivariate+DPOAE+metrics+for+identifying+changes+in+hearing%3A+Perspectives+from+ototoxicity+monitoring&rft.au=Konrad-Martin%2C+Dawn%3BReavis%2C+Kelly+M%3BMcmillan%2C+Garnett+P%3BDille%2C+Marilyn+F&rft.aulast=Konrad-Martin&rft.aufirst=Dawn&rft.date=2012-02-01&rft.volume=51&rft.issue=supplement+1&rft.spage=s51&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/10.3109%2F14992027.2011.635713 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hearing; Hearing impairment; Risk assessment; Learning; Models; Ears DO - http://dx.doi.org/10.3109/14992027.2011.635713 ER - TY - JOUR T1 - Optimizing Primary Care Telephone Access and Patient Satisfaction AN - 964268287; 201206927 AB - Telephone medicine is often preferred by patients to meet primary care needs and may be associated with high patient satisfaction. This article presents findings about incoming patient calls to primary care for medically based reasons during office hours and reports factors independently associated with telephone encounter satisfaction, considering patient characteristics, call reasons, and staff responsiveness, for a national cohort of primary care users. Interviews were conducted with patients from 18 nationwide primary care clinics during the fall of 2009. Calling for an urgent medical issue was associated with dissatisfaction. Odds of call satisfaction were greater when patients thought staff was friendly (10x), call answer was timely (5x), and needed medical information was provided (7x). These findings can be used for interventions to optimize telephone access and patient satisfaction which is beneficial because satisfactory telephone encounters reduce primary care use and satisfied patients are more likely to be engaged in their health care. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Evaluation & the Health Professions AU - LaVela, Sherri L AU - Gering, Jeffrey AU - Schectman, Gordon AU - Weaver, Frances M AD - Center for Management of Complex Chronic Care, Department of Veterans Affairs (DVA), Edward Hines Jr. VA Hospital, Hines, IL, USA, Feinberg School of Medicine, Institute for Healthcare Studies, Northwestern University, Chicago, IL, USA sherri.lavela@va.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 77 EP - 86 PB - Sage Publications, Thousand Oaks CA VL - 35 IS - 1 SN - 0163-2787, 0163-2787 KW - access to care patient satisfaction patient-centered care quality improvement telephone medicine KW - Telephones KW - Dissatisfaction KW - Health care KW - Patient satisfaction KW - Primary health care KW - Clinics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964268287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evaluation+%26+the+Health+Professions&rft.atitle=Optimizing+Primary+Care+Telephone+Access+and+Patient+Satisfaction&rft.au=LaVela%2C+Sherri+L%3BGering%2C+Jeffrey%3BSchectman%2C+Gordon%3BWeaver%2C+Frances+M&rft.aulast=LaVela&rft.aufirst=Sherri&rft.date=2012-01-01&rft.volume=35&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Evaluation+%26+the+Health+Professions&rft.issn=01632787&rft_id=info:doi/10.1177%2F0163278711411479 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - EHPRDK N1 - SubjectsTermNotLitGenreText - Primary health care; Telephones; Patient satisfaction; Clinics; Dissatisfaction; Health care DO - http://dx.doi.org/10.1177/0163278711411479 ER - TY - JOUR T1 - Age-related changes in the auditory brainstem response. AN - 963834377; pmid-22284838 AB - This cross-sectional study had two goals: (1) Identify and quantify the effects of aging on the auditory brainstem response (ABR); (2) Describe how click rate and hearing impairment modify effects of aging. RESEARCH DESIGN AND ANALYSIS: ABR measures were obtained from 131 predominately male Veteran participants aged 26 to 71 yr. Metrics analyzed include amplitude and latency for waves I, III, and V, and the I-V interpeak latency interval (IPI) at three repetition rates (11, 51, and 71 clicks/sec) using both polarities. In order to avoid confounding from missing data due to hearing impairment, participants had hearing thresholds <40 dB HL at 2 kHz and 70 dB HL at 4 kHz in at least one ear. Additionally, the median 2, 3, and 4 kHz pure tone threshold average (PTA2,3,4) for the sample, ∼17 dB HL, was used to delineate subgroups of better and worse hearing ears, and only the better hearing sample was modeled statistically. We modeled ABR responses using age, repetition rate, and PTA2,3,4 as covariates. Random effects were used to model correlation between the two ears of a subject and across repetition rates. Inferences regarding effects of aging on ABR measures at each rate were derived from the fitted model. Results were compared to data from subjects with poorer hearing.Aging substantially diminished amplitudes of all of the principal ABR peaks, largely independent of any threshold differences within the group. For waves I and III, age-related amplitude decrements were greatest at a low (11/sec) click rate. At the 11/sec rate, the model-based mean wave III amplitude was significantly smaller in older compared with younger subjects even after adjusting for wave I amplitude. Aging also increased ABR peak latencies, with significant shifts limited to early waves. The I-V IPI did not change with age. For both younger and older subjects, increasing click presentation rate significantly decreased amplitudes of early peaks and prolonged latencies of later peaks, resulting in increased IPIs. Advanced age did not enhance effects of rate. Instead, the rate effect on wave I and III amplitudes was attenuated for the older subjects due to reduced peak amplitudes at lower click rates. Compared with model predictions from the sample of better hearing subjects, mean ABR amplitudes were diminished in the group with poorer hearing, and wave V latencies were prolonged.In a sample of veterans, aging substantially reduced amplitudes of all principal ABR peaks, with significant latency shifts limited to waves I and III. Aging did not influence the I-V IPI even at high click rates, suggesting that the observed absolute latency changes associated with aging can be attributed to changes in auditory nerve input. In contrast, ABR amplitude changes with age are not adequately explained by changes in wave I. Results suggest that aging reduces the numbers and/or synchrony of contributing auditory nerve units. Results also support the concept that aging reduces the numbers, though perhaps not the synchrony, of central ABR generators.American Academy of Audiology. JF - Journal of the American Academy of Audiology AU - Konrad-Martin, Dawn AU - Dille, Marilyn F AU - McMillan, Garnett AU - Griest, Susan AU - McDermott, Daniel AU - Fausti, Stephen A AU - Austin, Donald F AD - VA RR&D National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Portland, OR 97239, USA. dawn.martin@va.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 18 EP - 35; quiz 74-5 VL - 23 IS - 1 SN - 1050-0545, 1050-0545 KW - National Library of Medicine KW - Adult KW - Age Distribution KW - Aged KW - *Aging: physiology KW - Audiometry, Pure-Tone KW - *Auditory Threshold: physiology KW - Cochlear Nerve: physiology KW - Cross-Sectional Studies KW - *Evoked Potentials, Auditory, Brain Stem: physiology KW - Female KW - Hearing Loss: epidemiology KW - *Hearing Loss: physiopathology KW - Humans KW - Male KW - Middle Aged KW - Presbycusis: epidemiology KW - *Presbycusis: physiopathology KW - Reaction Time: physiology KW - Regression Analysis KW - Sex Distribution KW - Veterans: statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/963834377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Age-related+changes+in+the+auditory+brainstem+response.&rft.au=Konrad-Martin%2C+Dawn%3BDille%2C+Marilyn+F%3BMcMillan%2C+Garnett%3BGriest%2C+Susan%3BMcDermott%2C+Daniel%3BFausti%2C+Stephen+A%3BAustin%2C+Donald+F&rft.aulast=Konrad-Martin&rft.aufirst=Dawn&rft.date=2012-01-01&rft.volume=23&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2012-04-05 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Biopsy Follow-Up of Prostate-Specific Antigen Tests AN - 925742253; 201206124 AB - A prostate-specific antigen (PSA) level above 4 ng/mL has historically been recognized as an appropriate threshold to recommend biopsy; however the risk of high-grade disease observed among men with lower PSA levels in the Prostate Cancer Prevention Trial has led to calls to change the criteria for biopsy referral. Purpose: To aid providers when discussing aggressiveness of biopsy by cataloging available community biopsy patterns and determine whether lower PSA thresholds are being used to recommend biopsy. Methods: Laboratory and biopsy records were reviewed among 59,764 men in a large Washington State health plan between 1998 and 2007. Follow-up in the 12-month period after a test was categorized as biopsy, urology visit without biopsy, additional PSA testing with no urology visit, or no PSA-related follow-up. Data analysis occurred between 2010 and 2011. Results: Twenty-eight percent of tests with PSA levels ^.4.0 ng/mL, 2.9% of tests with levels between 2.5 and 4.0 ng/mL, and 0.4% of tests with levels <2.5 ng/mL were followed with a biopsy within 12 months. More than 40% of elevated tests (^.4.0 ng/mL) were followed by a urologist visit without a biopsy, and more than 30% of tests ^.4.0 did not have any PSA-related follow-up within 12 months. PSA velocity, defined as annualized rate of change in PSA level, was strongly associated with biopsy, especially when absolute PSA was <4.0 ng/mL. There appear to be no discernable temporal trends in biopsy thresholds or practice patterns based on PSA lower levels or velocity. Conclusions: Despite recent calls to more aggressively recommend biopsy at lower PSA thresholds, the practice in this large health plan has remained consistent over time. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Zeliadt, Steven B AU - Buist, Diana S.M. AU - Reid, Robert J AU - Grossman, David C AU - Ma, Jian AU - Etzioni, Ruth AD - Health Services Research and Development Service, Department of Veterans Affairs Medical Center, University of Washington, Seattle, Washington steven.zeliadt@va.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 37 EP - 43 PB - Elsevier Science, New York NY VL - 42 IS - 1 SN - 0749-3797, 0749-3797 KW - Urology KW - Men KW - Laboratories KW - Health insurance KW - Biopsy KW - Thresholds KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925742253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Biopsy+Follow-Up+of+Prostate-Specific+Antigen+Tests&rft.au=Zeliadt%2C+Steven+B%3BBuist%2C+Diana+S.M.%3BReid%2C+Robert+J%3BGrossman%2C+David+C%3BMa%2C+Jian%3BEtzioni%2C+Ruth&rft.aulast=Zeliadt&rft.aufirst=Steven&rft.date=2012-01-01&rft.volume=42&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2011.08.024 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Biopsy; Thresholds; Urology; Health insurance; Men; Laboratories DO - http://dx.doi.org/10.1016/j.amepre.2011.08.024 ER - TY - JOUR T1 - Mental health disorders and the risk of AIDS-defining illness and death in HIV-infected veterans AN - 920795114; 16292172 AB - Objective: Mental health comorbidities are common in HIV-infected veterans and can impact clinical outcomes for HIV. We examined the impact of mental health diagnoses on progression to AIDS-defining illness (ADI) and death in a large cohort of HIV-infected veterans who accessed care between 2001 and 2006. Design: Retrospective cohort study using the national Veterans Health Administration (VHA) HIV Clinical Case Registry. Methods: We identified HIV-infected veterans initiating combination antiretroviral therapy (cART) within the VHA between 2000 and 2006. The prevalences of the following mental health diagnoses were examined: schizophrenia, bipolar disorder, depression, anxiety, and substance use disorder. Cox proportional hazards models were constructed to examine the relationship between mental health conditions and two outcomes, all-cause mortality and ADI. Models were computed before and after adjusting for confounding factors including age, race, baseline CD4 cell count, comorbidities and cART adherence. Results: Among 9003 veterans receiving cART, 31% had no mental health diagnosis. Age, race, baseline comorbidity score, CD4, and cART adherence were associated with shorter time to ADI or death. All-cause mortality was more likely among veterans with schizophrenia, bipolar disorder and substance use, and ADI was more likely to occur among veterans with substance use disorder. Conclusions: Our results demonstrate the high prevalence of mental health diagnoses among HIV-infected veterans. In the era of highly active antiretroviral therapy, presence of psychiatric diagnoses impacted survival and development of ADI. More aggressive measures addressing substance abuse and severe mental illness in HIV-infected veterans are necessary. JF - AIDS AU - Nurutdinova, D AU - Chrusciel, T AU - Zeringue, A AU - Scherrer, J F AU - Al-Aly, Z AU - McDonald, J R AU - Overton, E T AD - 915 North Grand Blvd, St. Louis, MO 63130, USA, diana.nurutdinova@va.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 229 EP - 234 VL - 26 IS - 2 SN - 0269-9370, 0269-9370 KW - Health & Safety Science Abstracts; Risk Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Mortality KW - Acquired immune deficiency syndrome KW - Age KW - Depression KW - Anxiety KW - substance use KW - Survival KW - Drug abuse KW - Morbidity KW - substance abuse KW - Schizophrenia KW - Mental disorders KW - CD4 antigen KW - Human immunodeficiency virus KW - Bipolar disorder KW - highly active antiretroviral therapy KW - antiretroviral agents KW - mental disorders KW - Races KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites KW - H 4000:Food and Drugs KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920795114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Mental+health+disorders+and+the+risk+of+AIDS-defining+illness+and+death+in+HIV-infected+veterans&rft.au=Nurutdinova%2C+D%3BChrusciel%2C+T%3BZeringue%2C+A%3BScherrer%2C+J+F%3BAl-Aly%2C+Z%3BMcDonald%2C+J+R%3BOverton%2C+E+T&rft.aulast=Nurutdinova&rft.aufirst=D&rft.date=2012-01-01&rft.volume=26&rft.issue=2&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0b013e32834e1404 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Mortality; Age; CD4 antigen; Mental disorders; Depression; Anxiety; highly active antiretroviral therapy; Bipolar disorder; Survival; Drug abuse; Races; substance abuse; Acquired immune deficiency syndrome; Human immunodeficiency virus; substance use; antiretroviral agents; mental disorders; Morbidity DO - http://dx.doi.org/10.1097/QAD.0b013e32834e1404 ER - TY - JOUR T1 - A procedure that differentiates unintentional from intentional overdose in opioid abusers. AN - 899130379; 21955872 AB - The purpose of this study is to develop a procedure for assessing unintentional overdose (OD) in opiate abusers that differentiates it from intentional OD, and provides reliable information about the incident. A sample of 121 patients in a methadone maintenance program at an urban university hospital completed a baseline assessment. A total of 70 participants completed an identical assessment at least 14 days later. The ability of an OD item to differentiate unintentional OD from intentional OD was tested, as was the test-retest reliability of questions assessing symptoms and treatment of OD. The procedure is reliable and differentiated unintentional OD from intentional OD. Questions assessing symptoms of OD were endorsed in almost every unintentional OD incident, although reliability was affected by loss of consciousness. The reliability of questions assessing emergency treatment and Narcan administration was outstanding. Our procedure for assessing OD differentiates unintentional OD from intentional OD. The use of follow-up questions assessing acute treatment for OD is recommended. Items concerning symptoms of OD are not needed to confirm the presence of an OD, but may be used to clarify whether an event was an OD. Published by Elsevier Ltd. JF - Addictive behaviors AU - Britton, Peter C AU - Bohnert, Amy S B AU - Wines, James D AU - Conner, Kenneth R AD - Center of Excellence, Department of Veteran Affairs Medical Center, Canandaigua, USA. peter.britton@va.gov Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 127 EP - 130 VL - 37 IS - 1 KW - Analgesics, Opioid KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Young Adult KW - Opiate Substitution Treatment KW - Methadone -- therapeutic use KW - Suicide, Attempted KW - Reproducibility of Results KW - Humans KW - Hospitals, University KW - Substance Abuse Treatment Centers KW - Adult KW - Surveys and Questionnaires KW - Follow-Up Studies KW - Middle Aged KW - Urban Population KW - Female KW - Male KW - Drug Overdose -- rehabilitation KW - Opioid-Related Disorders -- psychology KW - Opioid-Related Disorders -- rehabilitation KW - Intention KW - Analgesics, Opioid -- adverse effects KW - Drug Overdose -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899130379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=A+procedure+that+differentiates+unintentional+from+intentional+overdose+in+opioid+abusers.&rft.au=Britton%2C+Peter+C%3BBohnert%2C+Amy+S+B%3BWines%2C+James+D%3BConner%2C+Kenneth+R&rft.aulast=Britton&rft.aufirst=Peter&rft.date=2012-01-01&rft.volume=37&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=1873-6327&rft_id=info:doi/10.1016%2Fj.addbeh.2011.08.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-13 N1 - Date created - 2011-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.addbeh.2011.08.006 ER - TY - JOUR T1 - Ethics and Scientific Integrity in Public Health, Epidemiological and Clinical Research AN - 1611613842; 20673875 AB - The ethics and scientific integrity of biomedical and public health research requires that researchers behave in appropriate ways. However, this requires more than following of published research guidelines that seek to prevent scientific misconduct relating to serious deviations from widely accepted scientific norms for proposing, conducting, and reporting research (e.g., fabrication or falsification of research data or failures to report potential conflicts of interest). In this paper we argue for a broader account of scientific integrity, one consistent with that defended by the United States Institute of Medicine, involving a commitment to intellectual honesty and personal responsibility for one's actions as a researcher and to practices consistent with the responsible conduct of research and protection of the research participants. Maintaining high standards of ethical and scientific integrity helps to maintain public trust in the research enterprise. An increasing number of authors have pointed to the importance of mentoring and education in relation to the responsible conduct of science in preventing transgressions of scientific integrity. Just like in clinical research and biomedicine, epidemiologists and other public health researchers have the responsibility to exhibit and foster the very highest standards of scientific integrity. JF - Public Health Reviews AU - Coughlin, Steven S AU - Barker, Amyre AU - Dawson, Angus AD - Research Service, Veterans Affairs Medical Center, Washington, DC, USA; Food and Drug Administration, Rockville, MD, USA, steven.coughlin@va.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 1 EP - 13 PB - Technosdar Ltd., POB 31684 Tel Aviv 61316 Israel VL - 34 IS - 1 SN - 0301-0422, 0301-0422 KW - Health & Safety Science Abstracts KW - Ethics KW - clinical research KW - epidemiology KW - plagiarism KW - public health KW - scientific integrity KW - scientific misconduct KW - USA KW - Education KW - Responsibility KW - Reviews KW - Guidelines KW - Conflict of interests KW - Clinical trials KW - Public health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1611613842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reviews&rft.atitle=Ethics+and+Scientific+Integrity+in+Public+Health%2C+Epidemiological+and+Clinical+Research&rft.au=Coughlin%2C+Steven+S%3BBarker%2C+Amyre%3BDawson%2C+Angus&rft.aulast=Coughlin&rft.aufirst=Steven&rft.date=2012-01-01&rft.volume=34&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reviews&rft.issn=03010422&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-10-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Education; Responsibility; Reviews; Ethics; Conflict of interests; Guidelines; Clinical trials; Public health; USA ER - TY - JOUR T1 - Veterans Health Administration: A Model for Transforming Nursing Home Care AN - 1567030983; 201433224 AB - The Veterans Health Administration nursing homes, now called Community Living Centers (CLCs), are engaged in systematic transformation of their environments and their care and work practices. A brief history of nursing home care for Veterans illustrates the competing values that influence CLCs. Monitoring data show that CLCs have reduced institutional features, improved the personalization of care, and empowered direct care staff. Although CLCs differ in many respects from community nursing homes, their experiences offer valuable lessons for culture change, underline the complementary importance of top-level commitment and grassroots engagement, and offer untapped opportunities for research in environmental gerontology. Adapted from the source document. JF - Journal of Housing for the Elderly AU - Lemke, Sonne AD - Center for Health Care Evaluation, VA Palo Alto Health Care System, Menlo Park, California, USA Sonne.Lemke@va.gov Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 183 EP - 204 PB - Haworth Press/Taylor & Francis, Philadelphia PA VL - 26 IS - 1-3 SN - 0276-3893, 0276-3893 KW - Veterans KW - Community living KW - Community nursing KW - Health KW - Military hospitals KW - Nursing homes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1567030983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Housing+for+the+Elderly&rft.atitle=Veterans+Health+Administration%3A+A+Model+for+Transforming+Nursing+Home+Care&rft.au=Lemke%2C+Sonne&rft.aulast=Lemke&rft.aufirst=Sonne&rft.date=2012-01-01&rft.volume=26&rft.issue=1-3&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Journal+of+Housing+for+the+Elderly&rft.issn=02763893&rft_id=info:doi/10.1080%2F02763893.2012.658286 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JHELD2 N1 - SubjectsTermNotLitGenreText - Nursing homes; Military hospitals; Health; Community nursing; Community living; Veterans DO - http://dx.doi.org/10.1080/02763893.2012.658286 ER - TY - JOUR T1 - A qualitative study of anticipated barriers and facilitators to the implementation of nurse-delivered alcohol screening, brief intervention, and referral to treatment for hospitalized patients in a Veterans Affairs medical center AN - 1558989056; 201428131 AB - Unhealthy alcohol use includes the spectrum of alcohol consumption from risky drinking to alcohol use disorders. Routine alcohol screening, brief intervention (BI) and referral to treatment (RT) are commonly endorsed for improving the identification and management of unhealthy alcohol use in outpatient settings. However, factors which might impact screening, BI, and RT implementation in inpatient settings, particularly if delivered by nurses, are unknown, and must be identified to effectively plan randomized controlled trials (RCTs) of nurse-delivered BI. The purpose of this study was to identify the potential barriers and facilitators associated with nurse-delivered alcohol screening, BI and RT for hospitalized patients. Suggested facilitators of nurse-delivered screening, BI, and RT focused on provider- and system-level factors related to: (1) improved provider knowledge, skills, communication, and collaboration; (2) expanded processes of care and nursing roles; and (3) enhanced electronic medical record features. Adapted from the source document. JF - NIDA Addiction Science & Clinical Practice AU - Broyles, Lauren Matukaitis AU - Rodriguez, Keri L AU - Kraemer, Kevin L AU - Sevick, Mary Ann AU - Price, Patrice A AU - Gordon, Adam J AD - Center for Health Equity Research and Promotion, Veterans Affairs (VA) Pittsburgh Healthcare System, 7180 Highland Drive, Bldg. 2, Rm. 4020W (151C-H), Pittsburgh, PA 15206, USA; Division of General Internal Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA lauren.broyles@va.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 1 EP - 20 PB - RTI International, Rockville, MD VL - 7 SN - 1940-0632, 1940-0632 KW - Alcohol consumption Alcoholism Inpatients Nursing Nurses Implementation Screening Counseling Qualitative research Focus groups KW - Alcohol consumption KW - Screening KW - Referrals KW - Hospitalized KW - Brief interventions KW - Facilitators KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558989056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+Addiction+Science+%26+Clinical+Practice&rft.atitle=A+qualitative+study+of+anticipated+barriers+and+facilitators+to+the+implementation+of+nurse-delivered+alcohol+screening%2C+brief+intervention%2C+and+referral+to+treatment+for+hospitalized+patients+in+a+Veterans+Affairs+medical+center&rft.au=Broyles%2C+Lauren+Matukaitis%3BRodriguez%2C+Keri+L%3BKraemer%2C+Kevin+L%3BSevick%2C+Mary+Ann%3BPrice%2C+Patrice+A%3BGordon%2C+Adam+J&rft.aulast=Broyles&rft.aufirst=Lauren&rft.date=2012-01-01&rft.volume=7&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NIDA+Addiction+Science+%26+Clinical+Practice&rft.issn=19400632&rft_id=info:doi/10.1186%2F1940-0640-7-7 L2 - http://www.drugabuse.gov/ascp/index.html LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Screening; Alcohol consumption; Facilitators; Hospitalized; Brief interventions; Referrals DO - http://dx.doi.org/10.1186/1940-0640-7-7 ER - TY - JOUR T1 - Risk of future trauma based on alcohol screening scores: A two-year prospective cohort study among US veterans AN - 1558988501; 201429447 AB - Severe alcohol misuse as measured by the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) is associated with increased risk of future fractures and trauma-related hospitalizations. This study examined the association between AUDIT-C scores and two-year risk of any type of trauma among US Veterans Health Administration (VHA) patients and assessed whether risk varied by age or gender. Outpatients (215, 924 male and 9168 female) who returned mailed AUDIT-C questionnaires were followed for 24 months in the medical record for any International Statistical Classification of Diseases and Related Health Problems (ICD-9) code related to trauma. Men with severe alcohol misuse (AUDIT-C 9-12) demonstrate an increased risk of trauma. Men >, or = 65 showed an increased risk for trauma at all levels of alcohol misuse (AUDIT-C 5-8 and 9-12). These findings may be used as part of an evidence-based brief intervention for alcohol use disorders. More research is needed to understand the relationship between AUDIT-C scores and risk of trauma in women. Adapted from the source document. JF - NIDA Addiction Science & Clinical Practice AU - Harris, Alex H S AU - Lembke, Anna AU - Henderson, Patricia AU - Gupta, Shalini AU - Moos, Rudolf AU - Bradley, A AD - Center for Health Care Evaluation, VA Palo Alto Health Care System, 795 Willow Road, Menlo Park, CA 94025, USA Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 1 EP - 9 PB - RTI International, Rockville, MD VL - 7 SN - 1940-0632, 1940-0632 KW - Alcohol Trauma Fracture AUDIT-C Age Gender Screening Women KW - Health problems KW - Men KW - Alcohol abuse KW - Gender KW - Brief interventions KW - Alcohol related disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558988501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+Addiction+Science+%26+Clinical+Practice&rft.atitle=Risk+of+future+trauma+based+on+alcohol+screening+scores%3A+A+two-year+prospective+cohort+study+among+US+veterans&rft.au=Harris%2C+Alex+H+S%3BLembke%2C+Anna%3BHenderson%2C+Patricia%3BGupta%2C+Shalini%3BMoos%2C+Rudolf%3BBradley%2C+A&rft.aulast=Harris&rft.aufirst=Alex+H&rft.date=2012-01-01&rft.volume=7&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NIDA+Addiction+Science+%26+Clinical+Practice&rft.issn=19400632&rft_id=info:doi/10.1186%2F1940-0640-7-6 L2 - http://www.drugabuse.gov/ascp/index.html LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alcohol abuse; Alcohol related disorders; Men; Gender; Health problems; Brief interventions DO - http://dx.doi.org/10.1186/1940-0640-7-6 ER - TY - JOUR T1 - Feedback from recently returned veterans on an anonymous web-based brief alcohol intervention AN - 1558986429; 201430181 AB - Background: Veterans of Operation Enduring Freedom and Operation Iraqi Freedom (OEF/OIF) are at increased risk for alcohol misuse, and innovative methods are needed to improve their access to alcohol screening and brief interventions (SBI). This study adapted an electronic SBI (e-SBI) website shown to be efficacious in college students for OEF/OIF veterans and reported findings from interviews with OEF/OIF veterans about their impressions of the e-SBI. Methods: Outpatient veterans of OEF/OIF who drank > or =3 days in the past week were recruited from a US Department of Veterans Affairs (VA) Deployment Health Clinic waiting room. Veterans privately pretested the anonymous e-SBI then completed individual semistructured audio-recorded interviews. Their responses were analyzed using template analysis to explore domains identified a priori as well as emergent domains. Results: During interviews, all nine OEF/OIF veterans (1 woman and 8 men) indicated they had received feedback for risky alcohol consumption. Participants generally liked the standard-drinks image, alcohol-related caloric and monetary feedback, and the website's brevity and anonymity (a priori domains). They also experienced challenges with portions of the e-SBI assessment and viewed feedback regarding alcohol risk and normative drinking as problematic, but described potential benefits derived from the e-SBI (emergent domains). The most appealing e-SBIs would ensure anonymity and provide personalized transparent feedback about alcohol-related risk, consideration of the context for drinking, strategies to reduce drinking, and additional resources for veterans with more severe alcohol misuse. Conclusions: Results of this qualitative exploratory study suggest e-SBI may be an acceptable strategy for increasing OEF/OIF veteran access to evidenced-based alcohol SBI. Adapted from the source document. JF - NIDA Addiction Science & Clinical Practice AU - Lapham, Gwen T AU - Hawkins, Eric J AU - Chavez, Laura J AU - Achtmeyer, Carol E AU - Williams, Emily C AU - Thomas, Rachel M AU - Ludman, Evette J AU - Kypri, Kypros AU - Hunt, Stephen C AU - Bradley, Katharine A AD - Health Services Research & Development (HSR&D), Northwest Center of Excellence, Veterans Affairs (VA) Puget Sound Health Care System, 1100 Olive Way, Suite 1400, Seattle, WA 98101, USA; Department of Health Services, University of Washington, Box 357660, Seattle, WA 98195, USA gwendolyn.lapham@va.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 1 EP - 12 PB - RTI International, Rockville, MD VL - 7 SN - 1940-0632, 1940-0632 KW - Internet Alcohol Brief intervention Feedback Iraq war Veteran KW - Web sites KW - Alcohol consumption KW - Veterans KW - Freedom KW - Feedback KW - Alcohol related KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558986429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+Addiction+Science+%26+Clinical+Practice&rft.atitle=Feedback+from+recently+returned+veterans+on+an+anonymous+web-based+brief+alcohol+intervention&rft.au=Lapham%2C+Gwen+T%3BHawkins%2C+Eric+J%3BChavez%2C+Laura+J%3BAchtmeyer%2C+Carol+E%3BWilliams%2C+Emily+C%3BThomas%2C+Rachel+M%3BLudman%2C+Evette+J%3BKypri%2C+Kypros%3BHunt%2C+Stephen+C%3BBradley%2C+Katharine+A&rft.aulast=Lapham&rft.aufirst=Gwen&rft.date=2012-01-01&rft.volume=7&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NIDA+Addiction+Science+%26+Clinical+Practice&rft.issn=19400632&rft_id=info:doi/10.1186%2F1940-0640-7-17 L2 - http://www.drugabuse.gov/ascp/index.html LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Veterans; Feedback; Alcohol consumption; Freedom; Web sites; Alcohol related DO - http://dx.doi.org/10.1186/1940-0640-7-17 ER - TY - JOUR T1 - Pretransplant Physical Activity Predicts All-Cause Mortality in Kidney Transplant Recipients AN - 1458527655; 16280689 AB - Background: Low physical activity (PA) has been associated with higher rates of cardiovascular disease (CVD) and mortality in the general population. Despite the benefits of kidney transplantation, kidney transplant recipients (KTRs) remain at elevated risk for CVD and mortality compared to individuals without kidney disease. Methods: A prospective cohort of 507 adult KTRs from three academic centers completed the Physical Activity Scale for the Elderly (PASE) at transplantation. PASE scores were divided into tertiles. Results: PA was lower with older age, history of CVD, smoking, and diabetes. During the median 8-year follow-up period, 128 individuals died, among whom 101 had a functioning allograft. In multivariable Cox regression for all-cause mortality, greater PA was strongly associated with better survival (HR: 0.52 for most active vs. inactive tertiles, 95% CI: 0.31-0.87, p = 0.01). Secondary analyses, in which (1) death with a functioning graft was the primary outcome, and (2) PASE scores were converted to the metabolic equivalent of task, revealed similar results. We did not find an association between change of PA after transplantation and mortality. Conclusions: PA at the time of kidney transplantation is a strong predictor of all-cause mortality and death with graft function. Evaluation of PA level among kidney transplant candidates may be a useful method to risk-stratify patients for survival after kidney transplantation. Kidney transplant candidates and recipients should also be encouraged to be physically active. Copyright [copy 2011 S. Karger AG, Basel JF - American Journal of Nephrology AU - Rosas, Sylvia E AU - Reese, Peter P AU - Huan, Yonghong AU - Doria, Cataldo AU - Cochetti, Philip T AU - Doyle, Alden AD - Philadelphia Veterans Administration Medical Center Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 17 EP - 23 PB - S. Karger AG, P.O. Box Basel CH-4009 Switzerland VL - 35 IS - 1 SN - 0250-8095, 0250-8095 KW - Physical Education Index KW - Evaluation KW - Death KW - Analysis KW - Organ transplants KW - Gerontology KW - Cardiorespiratory KW - Kidneys KW - Exercise KW - Diseases KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1458527655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Nephrology&rft.atitle=Pretransplant+Physical+Activity+Predicts+All-Cause+Mortality+in+Kidney+Transplant+Recipients&rft.au=Rosas%2C+Sylvia+E%3BReese%2C+Peter+P%3BHuan%2C+Yonghong%3BDoria%2C+Cataldo%3BCochetti%2C+Philip+T%3BDoyle%2C+Alden&rft.aulast=Rosas&rft.aufirst=Sylvia&rft.date=2012-01-01&rft.volume=35&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Nephrology&rft.issn=02508095&rft_id=info:doi/10.1159%2F000334732 LA - English DB - Physical Education Index N1 - Date revised - 2013-11-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Evaluation; Death; Analysis; Gerontology; Organ transplants; Cardiorespiratory; Diseases; Exercise; Kidneys DO - http://dx.doi.org/10.1159/000334732 ER - TY - JOUR T1 - Human factors and ergonomics in patient safety curriculum AN - 1434025916; 18537693 AB - The importance of teaching human factors and ergonomics (HFE) and patient safety is registered in two compelling facts: 1) the numbers of physicians who train in VA hospitals and 2) in the need for hospitals to function as highly reliable organizations. In the United States, more than half of the physicians-in-training do at least part of their medical school and residency training at veterans' health care facilities. Health care currently does not measure up to other high-reliability organizations. By providing a HFE-based patient safety curriculum, we hope to improve patient safety at the frontlines. We see the lasting benefit as residency programs that produce physicians who are competent, patient safety problem solvers throughout their careers who will assist health care organizations to become highly reliable. [copy 2011 Wiley Periodicals, Inc. JF - Human Factors and Ergonomics in Manufacturing AU - Williams, Linda AU - Watts, Bradley V AU - McKnight, Scott AU - Bagian, James P AD - VA National Center for Patient Safety, White River Junction, VT., Linda.Williams7@va.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 64 EP - 71 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 22 IS - 1 SN - 1090-8471, 1090-8471 KW - Health & Safety Science Abstracts KW - Careers KW - USA KW - Ergonomics KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1434025916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Factors+and+Ergonomics+in+Manufacturing&rft.atitle=Human+factors+and+ergonomics+in+patient+safety+curriculum&rft.au=Williams%2C+Linda%3BWatts%2C+Bradley+V%3BMcKnight%2C+Scott%3BBagian%2C+James+P&rft.aulast=Williams&rft.aufirst=Linda&rft.date=2012-01-01&rft.volume=22&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Human+Factors+and+Ergonomics+in+Manufacturing&rft.issn=10908471&rft_id=info:doi/10.1002%2Fhfm.20282 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-09-01 N1 - Last updated - 2014-03-10 N1 - SubjectsTermNotLitGenreText - Ergonomics; USA DO - http://dx.doi.org/10.1002/hfm.20282 ER - TY - JOUR T1 - Medication review software to improve the accuracy of outpatient medication histories: protocol for a randomized controlled trial AN - 1434023951; 18537701 AB - Medication-prescribing errors generated at interfaces-in-care are the most common cause of preventable health care errors and contribute substantially to adverse patient outcomes. For this reason, standardized medication reconciliation (MR) processes need to be inserted at these interfaces. However, MR is an inherently complex task, and little data exist to inform system-based operationalization. The Portland Informatics Center addressed this challenge by creating an electronic patient-directed multimedia survey to automate the medication history collection. This article describes a research protocol designed to compare the software's medication discrepancy detection rate with traditional history collection strategies. For this randomized, controlled, single-blind trial, participants are randomly allocated into one of two groups: the control group reviews a paper list printed from the electronic record, whereas the intervention group uses a computer-assisted reconciliation survey that includes display of visual data (i.e., medication pictures). [copy 2011 Wiley Periodicals, Inc. JF - Human Factors and Ergonomics in Manufacturing AU - Lesselroth, Blake J AU - Dorr, David A AU - Adams, Kathleen AU - Church, Victoria AU - Adams, Shawn AU - Mazur, Dennis AU - Russ, Yelizaveta AU - Felder, Robert AU - Douglas, David M AD - Oregon Health and Sciences University, Portland, Oregon., blake.lesselroth@va.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 72 EP - 86 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 22 IS - 1 SN - 1090-8471, 1090-8471 KW - Health & Safety Science Abstracts KW - Historical account KW - Computer programs KW - Health care KW - Informatics KW - Reviews KW - Intervention KW - Standards KW - Human factors KW - Drugs KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1434023951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Factors+and+Ergonomics+in+Manufacturing&rft.atitle=Medication+review+software+to+improve+the+accuracy+of+outpatient+medication+histories%3A+protocol+for+a+randomized+controlled+trial&rft.au=Lesselroth%2C+Blake+J%3BDorr%2C+David+A%3BAdams%2C+Kathleen%3BChurch%2C+Victoria%3BAdams%2C+Shawn%3BMazur%2C+Dennis%3BRuss%2C+Yelizaveta%3BFelder%2C+Robert%3BDouglas%2C+David+M&rft.aulast=Lesselroth&rft.aufirst=Blake&rft.date=2012-01-01&rft.volume=22&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Human+Factors+and+Ergonomics+in+Manufacturing&rft.issn=10908471&rft_id=info:doi/10.1002%2Fhfm.20287 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-09-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Computer programs; Historical account; Health care; Informatics; Reviews; Intervention; Standards; Human factors; Drugs DO - http://dx.doi.org/10.1002/hfm.20287 ER - TY - JOUR T1 - Staff and patient safety: Issues surrounding the use of fall-injury-protection bedside floor mats at a large southeastern VA medical center community living center AN - 1434022951; 18537694 AB - Staff and patient injuries have been realized secondary to the use of fall-injury protection bedside floor mats at certain VA hospitals. The purpose of this investigation was to ascertain whether patient and staff injuries occurred at our Veterans Administration Medical Center community living center (CLC) from these mats. A review of the OSHA 300 log, the administration of a questionnaire to staff, and patient safety, Community Living Center, and occupational health staff interviews regarding patient and staff injuries from mats were used in the investigation. Clinical significance was defined as staff or resident injuries from mats, and statistical significance was defined as statistically significant greater odds (Chi square at alpha of 0.05, and 95% odds ratio CIs) of staff being injured from mats versus other equipment in the workspace. The clinically significant criterion of staff and patient injuries from mats was realized; however, there were no statistically significant greater odds of staff injuries from mats compared with other equipment. The introduction of new technology into the patient and staff workspace, such as bedside floor mats, should take into consideration the possibility of creating new workspace hazards and vulnerabilities. End-user usability testing and feedback should be considered as essential components of an implementation process. Further investigations could focus on underreporting of staff and patient injuries, cost--benefit and risk--benefit analyses with regard to resident injuries and resident injury protection as a function of bedside mats, and investigating other potentially hazardous equipment in the workspace. [copy 2011 Wiley Periodicals, Inc. JF - Human Factors and Ergonomics in Manufacturing AU - Bradley, Melville AD - VA VISN 8 Patient Safety Center of Inquiry, 8900 Grand Oaks Circle (118M), Tampa, Florida 33637-1012; Phone: (813)903-4298., melville.bradley2@va.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 32 EP - 38 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 22 IS - 1 SN - 1090-8471, 1090-8471 KW - Health & Safety Science Abstracts KW - Federal regulations KW - Safety regulations KW - Injuries KW - Reviews KW - Human factors KW - Vulnerability KW - Ergonomics KW - Hospitals KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1434022951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Factors+and+Ergonomics+in+Manufacturing&rft.atitle=Staff+and+patient+safety%3A+Issues+surrounding+the+use+of+fall-injury-protection+bedside+floor+mats+at+a+large+southeastern+VA+medical+center+community+living+center&rft.au=Bradley%2C+Melville&rft.aulast=Bradley&rft.aufirst=Melville&rft.date=2012-01-01&rft.volume=22&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Human+Factors+and+Ergonomics+in+Manufacturing&rft.issn=10908471&rft_id=info:doi/10.1002%2Fhfm.20279 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-09-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Federal regulations; Safety regulations; Injuries; Reviews; Vulnerability; Human factors; Ergonomics; Occupational health; Hospitals DO - http://dx.doi.org/10.1002/hfm.20279 ER - TY - JOUR T1 - Physical Activity, Health Benefits, and Mortality Risk AN - 1372053910; 18106654 AB - A plethora of epidemiologic evidence from large studies supports unequivocally an inverse, independent, and graded association between volume of physical activity, health, and cardiovascular and overall mortality. This association is evident in apparently healthy individuals, patients with hypertension, type 2 diabetes mellitus, and cardiovascular disease, regardless of body weight. Moreover, the degree of risk associated with physical inactivity is similar to, and in some cases even stronger than, the more traditional cardiovascular risk factors. The exercise-induced health benefits are in part related to favorable modulations of cardiovascular risk factors observed by increased physical activity or structured exercise programs. Although the independent contribution of the exercise components, intensity, duration, and frequency to the reduction of mortality risk is not clear, it is well accepted that an exercise volume threshold defined at caloric expenditure of approximately 1,000 Kcal per week appears to be necessary for significant reduction in mortality risk. Further reductions in risk are observed with higher volumes of energy expenditure. Physical exertion is also associated with a relatively low and transient increase in risk for cardiac events. This risk is significantly higher for older and sedentary individuals. Therefore, such individuals should consult their physician prior to engaging in exercise. JF - ISRN Cardiology AU - Kokkinos, Peter AD - Cardiology Department, Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA, peter.kokkinos@va.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2012 KW - Physical Education Index; Health & Safety Science Abstracts; Risk Abstracts KW - Body weight KW - Physical activity KW - Health KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1372053910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ISRN+Cardiology&rft.atitle=Physical+Activity%2C+Health+Benefits%2C+and+Mortality+Risk&rft.au=Kokkinos%2C+Peter&rft.aulast=Kokkinos&rft.aufirst=Peter&rft.date=2012-01-01&rft.volume=2012&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=ISRN+Cardiology&rft.issn=2090-5599&rft_id=info:doi/10.5402%2F2012%2F718789 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2013-06-01 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - Health; Physical activity DO - http://dx.doi.org/10.5402/2012/718789 ER - TY - JOUR T1 - Islamic Ontology Of Death Anxiety In The Work Of Abdel-Khalek AN - 1347816924; 201305599 AB - This is a book review of Abdel-Khalek's (2005) Arabic Handbook on "Death and Dying." This review extrapolates the Islamic ontology presented in 492 pages covering 56 empirical and 304 empirical studies published by a host of Arab, American and European psychologists and psychiatrists. The Handbook presents an Islamic ontology on death anxiety for the first time to English readers. Freud's Judeo-Christian view of death anxiety is already familiar to readers of Omega. But the Islamic ontology of death is relatively unknown even though it is relevant. This reviewer finds the Islamic ontology of death to be similar to the Judeo-Christian one. Islam provides believers with assurance of God's mercy regardless of human vulnerability to evil. Death anxiety can be relieved by exercising moderation in relations with others. Quoting from the Qur'an, Abdel-Khalek (2005) makes the claim that there is a judicious path to follow between daily distress and achieving social goals. The Arabic term to describe this path is Surat-Mustakeem. It comes close to Aristotle's Eudaimona or happiness. Death Anxiety is neither negative nor positive in connotation. It is the ethical pursuit of a dialectic of truth and virtue. Death anxiety research shows a convergence between ontology and empirical research. Adapted from the source document. JF - Omega - Journal of Death and Dying AU - Beshai, James A AD - VAMC, Lebanon, PA., 1700 S. Lincoln Ave., Lebanon, PA 17042 James.Beshai@va.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 89 EP - 96 PB - Baywood Publishing, Amityville NY VL - 66 IS - 1 SN - 0030-2228, 0030-2228 KW - Virtue KW - Death KW - Islam KW - Psychiatrists KW - Death anxiety KW - Manuals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1347816924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Omega+-+Journal+of+Death+and+Dying&rft.atitle=Islamic+Ontology+Of+Death+Anxiety+In+The+Work+Of+Abdel-Khalek&rft.au=Beshai%2C+James+A&rft.aulast=Beshai&rft.aufirst=James&rft.date=2012-01-01&rft.volume=66&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Omega+-+Journal+of+Death+and+Dying&rft.issn=00302228&rft_id=info:doi/10.2190%2FOM.66.1.f LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - OMGABX N1 - SubjectsTermNotLitGenreText - Death anxiety; Islam; Death; Manuals; Virtue; Psychiatrists DO - http://dx.doi.org/10.2190/OM.66.1.f ER - TY - JOUR T1 - Immunoliposome-PCR: a generic ultrasensitive quantitative antigen detection system AN - 1328513230; 17381128 AB - Background: The accurate quantification of antigens at low concentrations over a wide dynamic range is needed for identifying biomarkers associated with disease and detecting protein interactions in high-throughput microarrays used in proteomics. Here we report the development of an ultrasensitive quantitative assay format called immunoliposome polymerase chain reaction (ILPCR) that fulfills these requirements. This method uses a liposome, with reporter DNA encapsulated inside and biotin-labeled polyethylene glycol (PEG) phospholipid conjugates incorporated into the outer surface of the liposome, as a detection reagent. The antigenic target is immobilized in the well of a microplate by a capture antibody and the liposome detection reagent is then coupled to a biotin-labeled second antibody through a NeutrAvidin bridge. The liposome is ruptured to release the reporter DNA, which serves as a surrogate to quantify the protein target using real-time PCR. Results: A liposome detection reagent was prepared, which consisted of a population of liposomes ~120 nm in diameter with each liposome possessing ~800 accessible biotin receptors and ~220 encapsulated reporters. This liposome detection reagent was used in an assay to quantify the concentration of carcinoembryonic antigen (CEA) in human serum. This ILPCR assay exhibited a linear dose-response curve from 10 super(-10) M to 10 super(-16) M CEA. Within this range the assay coefficient of variance was <6 % for repeatability and <2 % for reproducibility. The assay detection limit was 13 fg/mL, which is 1,500-times more sensitive than current clinical assays for CEA. An ILPCR assay to quantify HIV-1 p24 core protein in buffer was also developed. Conclusions: The ILPCR assay has several advantages over other immuno-PCR methods. The reporter DNA and biotin-labeled PEG phospholipids spontaneously incorporate into the liposomes as they form, simplifying preparation of the detection reagent. Encapsulation of the reporter inside the liposomes allows nonspecific DNA in the assay medium to be degraded with DNase I prior to quantification of the encapsulated reporter by PCR, which reduces false-positive results and improves quantitative accuracy. The ability to encapsulate multiple reporters per liposome also helps overcome the effect of polymerase inhibitors present in biological specimens. Finally, the biotin-labeled liposome detection reagent can be coupled through a NeutrAvidin bridge to a multitude of biotin-labeled probes, making ILPCR a highly generic assay system. JF - Journal of Nanobiotechnology AU - He, Junkun AU - Evers, David L AU - O'Leary, Timothy J AU - Mason, Jeffrey T AD - Biomedical Laboratory Research and Development Service, Veterans Health Administration, Washington, DC, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 26 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 10 IS - 1 SN - 1477-3155, 1477-3155 KW - Biotechnology and Bioengineering Abstracts KW - Carcinoembryonic antigen KW - Probes KW - biomarkers KW - Liposomes KW - Encapsulation KW - Antibodies KW - Human immunodeficiency virus 1 KW - Polymerase chain reaction KW - Deoxyribonuclease KW - proteomics KW - Polyethylene glycol KW - Biotin KW - Protein interaction KW - Core protein KW - Phospholipids KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1328513230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nanobiotechnology&rft.atitle=Immunoliposome-PCR%3A+a+generic+ultrasensitive+quantitative+antigen+detection+system&rft.au=He%2C+Junkun%3BEvers%2C+David+L%3BO%27Leary%2C+Timothy+J%3BMason%2C+Jeffrey+T&rft.aulast=He&rft.aufirst=Junkun&rft.date=2012-01-01&rft.volume=10&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nanobiotechnology&rft.issn=14773155&rft_id=info:doi/10.1186%2F1477-3155-10-26 L2 - http://www.jnanobiotechnology.com/content/10/1/26 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-04-01 N1 - Number of references - 82 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Carcinoembryonic antigen; Probes; Liposomes; biomarkers; Encapsulation; Antibodies; Polymerase chain reaction; Deoxyribonuclease; proteomics; Biotin; Polyethylene glycol; Protein interaction; Phospholipids; Core protein; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1186/1477-3155-10-26 ER - TY - JOUR T1 - Advanced earthquake monitoring system for U.S. Department of Veterans Affairs medical buildings; instrumentation AN - 1320154347; 2013-028505 AB - In collaboration with the U.S. Department of Veterans Affairs (VA), the National Strong Motion Project (NSMP; http://nsmp.wr.usgs.gov/, http://nsmp.wr.usgs.gov/) of the U.S. Geological Survey has been installing sophisticated seismic systems that will monitor the structural integrity of 28 VA hospital buildings located in seismically active regions of the conterminous United States, Alaska, and Puerto Rico during earthquake shaking. These advanced monitoring systems, which combine the use of sensitive accelerometers and real-time computer calculations, are designed to determine the structural health of each hospital building rapidly after an event, helping the VA to ensure the safety of patients and staff. This report presents the instrumentation component of this project by providing details of each hospital building, including a summary of its structural, geotechnical, and seismic hazard information, as well as instrumentation objectives and design. The structural-health monitoring component of the project, including data retrieval and processing, damage detection and localization, automated alerting system, and finally data dissemination, will be presented in a separate report. JF - Open-File Report - U. S. Geological Survey AU - Kalkan, Erol AU - Banga, Krishna AU - Ulusoy, Hasan S AU - Fletcher, Jon Peter B AU - Leith, William S AU - Reza, Shahneam AU - Cheng, Timothy Y1 - 2012 PY - 2012 DA - 2012 SP - 143 PB - U. S. Geological Survey, Reston, VA SN - 0196-1497, 0196-1497 KW - United States KW - civil engineering KW - monitoring KW - geologic hazards KW - government agencies KW - seismic response KW - seismicity KW - building codes KW - natural hazards KW - buildings KW - USGS KW - earthquakes KW - instruments KW - 30:Engineering geology KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1320154347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Open-File+Report+-+U.+S.+Geological+Survey&rft.atitle=Advanced+earthquake+monitoring+system+for+U.S.+Department+of+Veterans+Affairs+medical+buildings%3B+instrumentation&rft.au=Kalkan%2C+Erol%3BBanga%2C+Krishna%3BUlusoy%2C+Hasan+S%3BFletcher%2C+Jon+Peter+B%3BLeith%2C+William+S%3BReza%2C+Shahneam%3BCheng%2C+Timothy&rft.aulast=Kalkan&rft.aufirst=Erol&rft.date=2012-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Open-File+Report+-+U.+S.+Geological+Survey&rft.issn=01961497&rft_id=info:doi/ L2 - http://pubs.usgs.gov/of/2012/1241/ https://pubs.er.usgs.gov/browse/usgs-publications/OFR LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2013-01-01 N1 - Number of references - 4 N1 - PubXState - VA N1 - Document feature - illus. incl. 1 table, sketch map N1 - SuppNotes - Accessed on Feb. 12, 2013; includes appendices N1 - Last updated - 2016-10-25 N1 - CODEN - XGROAG N1 - SubjectsTermNotLitGenreText - building codes; buildings; civil engineering; earthquakes; geologic hazards; government agencies; instruments; monitoring; natural hazards; seismic response; seismicity; United States; USGS ER - TY - JOUR T1 - Male-to-Female Transgender Veterans and VA Health Care Utilization AN - 1315875443; 2011-363110 AB - This study examined rates of military veteran status in an American male-to-female transgender community sample (n = 141). Thirty percent were veterans (n = 43), a rate that is triple the proportion of veteran status noted in the general population (10.1%). Among the veteran subsample, we examined health care utilization, including Veterans Health Administration (VA), health, and barriers to care. Use of VA services was higher among transgender veterans (transvets) than published rates of VA use in the general population of veterans (annual 6.2% to 15.8%), with 16.3% of all transvets seeking some VA care in the past 6- months. The most common physical health problems treated at the VA in the past year were high cholesterol, blood pressure, and vision problems. Irrespective of VA use, the majority of transvets reported getting routine health care (88.4%), and their physical health ratings were commensurate with population norms. Mental health services (e.g., depression, posttraumatic stress disorder, and gender identity counseling) were also utilized (9.3% VA, 25.6% non-VA) at levels consistent with the relatively low mental health functioning scores in this sample (SF-12 = 32.6, SD = 8.3). Barriers to care were endorsed more for medical than mental health treatment. In particular, transvets were concerned about medical providers' reactions to their gender identity or sexual orientation. Given elevated rates of transvets in this community sample and reported barriers to care, culturally sensitive treatment is a priority for transvets in both VA and non-VA health care systems. Adapted from the source document. JF - International Journal of Sexual Health AU - Shipherd, Jillian C AU - Mizock, Lauren AU - Maguen, Shira AU - Green, Kelly E AD - Department of Veterans Affairs, VA Boston Healthcare System, Boston, Massachusetts, USA Jillian.shipherd@va.gov Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 78 EP - 87 PB - Taylor & Francis, Philadelphia PA VL - 24 IS - 1 SN - 1931-7611, 1931-7611 KW - Health conditions and policy - Health and health policy KW - Military and defense policy - Military personnel and veterans KW - Health conditions and policy - Medicine and health care KW - Population groups, population policy, and demographics - Demography and census KW - Science and technology policy - Biology and biotechnology KW - Social conditions and policy - Sex KW - Social conditions and policy - Psychology KW - Transgender transsexual gender veteran service utilization barriers to care KW - Veterans KW - Blood KW - Mental health services KW - Mental health KW - Population KW - Sexual orientation KW - Reproductive health KW - Counseling KW - Medical service KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1315875443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Sexual+Health&rft.atitle=Male-to-Female+Transgender+Veterans+and+VA+Health+Care+Utilization&rft.au=Shipherd%2C+Jillian+C%3BMizock%2C+Lauren%3BMaguen%2C+Shira%3BGreen%2C+Kelly+E&rft.aulast=Shipherd&rft.aufirst=Jillian&rft.date=2012-01-01&rft.volume=24&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Sexual+Health&rft.issn=19317611&rft_id=info:doi/10.1080%2F19317611.2011.639440 LA - English DB - PAIS Index N1 - Date revised - 2013-03-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Reproductive health; Veterans; Medical service; Population; Mental health; Blood; Mental health services; Sexual orientation; Counseling DO - http://dx.doi.org/10.1080/19317611.2011.639440 ER - TY - JOUR T1 - Introduction to Special Issue on Veterans' Sexual Health and Functioning AN - 1315875422; 2011-363104 AB - The literature on military veterans' sexual health and functioning is largely limited to medication effects on desire and arousal and to military sexual trauma. This is the first scientific journal issue devoted to the sexual health and functioning of military veterans. Four papers describe the effects of combat experiences on American veterans' sexual functioning, sexual risk behavior, mental health, health status, and relationships. One paper describes the effects of sexual assault on women's sexual health, and one paper describes health care utilization among transgender veterans. Studies outside of the United States are needed to understand cultural and health care system differences. Adapted from the source document. JF - International Journal of Sexual Health AU - Kauth, Michael R AD - South Central Mental Illness Research, Education, and Clinical Center, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA Michael.kauth@va.gov Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 1 EP - 5 PB - Taylor & Francis, Philadelphia PA VL - 24 IS - 1 SN - 1931-7611, 1931-7611 KW - Health conditions and policy - Health and health policy KW - Military and defense policy - Military personnel and veterans KW - Health conditions and policy - Medicine and health care KW - Population groups, population policy, and demographics - Women KW - Administration of justice - Crime and criminals KW - Adult sexuality sexual function sexual health promotion KW - United States KW - Veterans KW - Sex crimes KW - Women KW - Mental health KW - Reproductive health KW - Medical service KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1315875422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Sexual+Health&rft.atitle=Introduction+to+Special+Issue+on+Veterans%27+Sexual+Health+and+Functioning&rft.au=Kauth%2C+Michael+R&rft.aulast=Kauth&rft.aufirst=Michael&rft.date=2012-01-01&rft.volume=24&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Sexual+Health&rft.issn=19317611&rft_id=info:doi/10.1080%2F19317611.2011.645948 LA - English DB - PAIS Index N1 - Date revised - 2013-03-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Reproductive health; Veterans; Medical service; United States; Women; Sex crimes; Mental health DO - http://dx.doi.org/10.1080/19317611.2011.645948 ER - TY - JOUR T1 - Military Sexual Trauma During Deployment to Iraq and Afghanistan: Prevalence, Readjustment, and Gender Differences AN - 1315601966; 201301760 AB - This study examines military sexual trauma (MST) in men and women deployed in the wars in Iraq and Afghanistan. A diverse sample of 470 (408 men and 62 women) completed anonymous self-report questionnaires. Seventy-seven reported MST: 51 (12.5%) men and 26 (42%) women. MST was significantly related to symptoms and readjustment and most strongly with intimacy problems. Of those with MST, 73% also reported exposure to war-related stressors. Gender differences revealed that women reported a higher prevalence of MST, but men were more likely to endorse MST with multiple war-related stressors. However, no gender differences were found on reports of symptoms, posttraumatic stress disorder (PTSD), or readjustment. Implications of these results are discussed. Adapted from the source document. JF - Violence and Victims AU - Katz, Lori S AU - Cojucar, Geta AU - Beheshti, Sayeh AU - Nakamura, Erin AU - Murray, Michelle AD - Women's Mental Health Center, VA Long Beach Healthcare System, 5901 East Seventh Street, 116B, Long Beach, CA 90822 lori.katz@va.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 487 EP - 499 PB - Springer Publishing Co., New York NY VL - 27 IS - 4 SN - 0886-6708, 0886-6708 KW - military sexual trauma, conflicts in Iraq and Afghanistan, OIF/OEF, gender differences KW - War KW - Military Personnel KW - Stress KW - Afghanistan KW - Sexual Abuse KW - Armed Forces KW - Posttraumatic Stress Disorder KW - Iraq KW - Trauma KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1315601966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Violence+and+Victims&rft.atitle=Military+Sexual+Trauma+During+Deployment+to+Iraq+and+Afghanistan%3A+Prevalence%2C+Readjustment%2C+and+Gender+Differences&rft.au=Katz%2C+Lori+S%3BCojucar%2C+Geta%3BBeheshti%2C+Sayeh%3BNakamura%2C+Erin%3BMurray%2C+Michelle&rft.aulast=Katz&rft.aufirst=Lori&rft.date=2012-01-01&rft.volume=27&rft.issue=4&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Violence+and+Victims&rft.issn=08866708&rft_id=info:doi/10.1891%2F0886-6708.27.4.487 LA - English DB - Social Services Abstracts N1 - Date revised - 2014-02-21 N1 - Number of references - 27 N1 - Last updated - 2016-09-28 N1 - CODEN - VIOVEI N1 - SubjectsTermNotLitGenreText - Sexual Abuse; Posttraumatic Stress Disorder; Iraq; Stress; Afghanistan; Trauma; Armed Forces; War; Military Personnel DO - http://dx.doi.org/10.1891/0886-6708.27.4.487 ER - TY - JOUR T1 - Correlates of Sexual Functioning in Women Veterans: Mental Health, Gynecologic Health, Health Status, and Sexual Assault History AN - 1268656721; 17488034 AB - Military women are a unique population with occupational risks that may influence their sexual health, yet relatively little is known about specific correlates associated with servicewomen's sexual functioning. One thousand and four Midwestern U.S. women veterans aged 52 years of age and younger completed a telephone interview assessing sexual assault history, mental health, gynecologic health, and health-related quality of life. Half experienced at least one completed sexual assault during their lifetime. Most (68%) reported sex was important in their lives, and three quarters (74%) indicated that they had engaged in sex with a partner during the past 6 months. Almost one quarter of sexually active participants reported painful sexual intercourse, and approximately one third (35%) acknowledged using lubricants often to make sex comfortable. Mental health disorders (posttraumatic stress disorder, depression, and substance use disorder), gynecologic injuries resulting from completed sexual assault, and poor health-related quality of life were common in this sample and were associated with compromised sexual functioning. Most sexually active women endorsing these correlates were more likely to report not being emotionally satisfied with their main partner. Problems with sexual functioning and pain during intercourse were associated with even a single completed lifetime sexual assault (cLSA). These correlates should alert health care providers to inquire regarding sensitive topics such as LSA exposure and other factors (e.g., painful sex, same-sex partners, and mental health). Sexual health problems are important to address and may also signal other important health concerns. JF - International Journal of Sexual Health AU - Sadler, Anne G AU - Mengeling, Michelle A AU - Fraley, Sarah S AU - Torner, James C AU - Booth, Brenda M AD - Comprehensive Access & Delivery Research and Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, Iowa, USA, anne.sadler@va.gov Y1 - 2012/01/01/ PY - 2012 DA - 2012 Jan 01 SP - 60 EP - 77 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 24 IS - 1 SN - 1931-7611, 1931-7611 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Females KW - Health care KW - Health problems KW - Historical account KW - Mental disorders KW - Military KW - Quality of life KW - Sexual assault KW - Sexual behavior KW - USA KW - H 1000:Occupational Safety and Health KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1268656721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Sexual+Health&rft.atitle=Correlates+of+Sexual+Functioning+in+Women+Veterans%3A+Mental+Health%2C+Gynecologic+Health%2C+Health+Status%2C+and+Sexual+Assault+History&rft.au=Sadler%2C+Anne+G%3BMengeling%2C+Michelle+A%3BFraley%2C+Sarah+S%3BTorner%2C+James+C%3BBooth%2C+Brenda+M&rft.aulast=Sadler&rft.aufirst=Anne&rft.date=2012-01-01&rft.volume=24&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Sexual+Health&rft.issn=19317611&rft_id=info:doi/10.1080%2F19317611.2011.640388 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-01-01 N1 - Last updated - 2013-02-22 N1 - SubjectsTermNotLitGenreText - Historical account; Health problems; Mental disorders; Health care; Sexual assault; Females; Military; Sexual behavior; Quality of life; USA DO - http://dx.doi.org/10.1080/19317611.2011.640388 ER - TY - JOUR T1 - Increasing Marital Satisfaction as a Resilience Factor Among Active Duty Members and Veterans of Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF) AN - 1266148556; 201300421 AB - Supportive relationships are protective against a number of prevalent health risks among military populations, including post-traumatic stress disorder. Increasing marital satisfaction and strengthening that relationship is an important avenue for maintaining health among returning service members and their families. The current study builds upon two earlier studies that were limited to National Guard personnel from one state. An exploratory survey was employed to identify variables that influenced marital satisfaction among Operation Iraqi Freedom and Operation Enduring Freedom veterans. Using regression analysis, the statistically significant predictive model included five variables. In addition to the identification of this predictive model, other variables found to be non-predictive are reported. Adapted from the source document. JF - Journal of Family Social Work AU - Ponder, Warren N AU - Aguirre, Regina T P AU - Smith-Osborne, Alexa AU - Granvold, Donald K AD - Readjustment Counseling Service, United States Department of Veterans Affairs, Fort Worth, Texas Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 3 EP - 18 PB - Haworth Press/Taylor & Francis, Philadelphia PA VL - 15 IS - 1 SN - 1052-2158, 1052-2158 KW - Operation Enduring Freedom marital satisfaction post-traumatic stress disorder Operation Iraqi Freedom KW - Resilience KW - Veterans KW - Prediction KW - Stress KW - Family KW - Freedom KW - Health KW - Marital Satisfaction KW - Health Care Services KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266148556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Social+Work&rft.atitle=Increasing+Marital+Satisfaction+as+a+Resilience+Factor+Among+Active+Duty+Members+and+Veterans+of+Operation+Iraqi+Freedom+%28OIF%29+and+Operation+Enduring+Freedom+%28OEF%29&rft.au=Ponder%2C+Warren+N%3BAguirre%2C+Regina+T+P%3BSmith-Osborne%2C+Alexa%3BGranvold%2C+Donald+K&rft.aulast=Ponder&rft.aufirst=Warren&rft.date=2012-01-01&rft.volume=15&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Social+Work&rft.issn=10522158&rft_id=info:doi/10.1080%2F10522158.2012.640815 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-01-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JFSWEO N1 - SubjectsTermNotLitGenreText - Freedom; Marital Satisfaction; Prediction; Veterans; Health Care Services; Resilience; Family; Stress; Health DO - http://dx.doi.org/10.1080/10522158.2012.640815 ER - TY - JOUR T1 - Validation of the Suicide Resilience Inventory-25 (SRI-25) in Adolescent Psychiatric Inpatient Samples AN - 1221434738; 201228614 AB - Resilience has been associated with a markedly decreased chance for risky behaviors following a trauma or other negative life event. This study examined the factor structure and psychometric properties of a self-report measure of resilience, the Suicide Resilience Inventory-25 (SRI-25; Osman et al., 2004 ), among psychiatric inpatient adolescents. In Study 1, we conducted confirmatory factor analysis to provide additional empirical support for the structure and invariance of the 3-factor model of the SRI-25 in youth samples, ages 14 to 17 years (N = 152 boys, 220 girls). Scale reliability analyses provided good evidence for internal consistency reliability of scores on the SRI-25 total and scales. In Study 2 (N = 30 boys, 40 girls), we presented data in support for the concurrent validity (i.e., known groups) of scores on the SRI-25. Additionally, we identified potential correlates for the SRI-25 total scale scores. Adapted from the source document. JF - Journal of Personality Assessment AU - Gutierrez, Peter M AU - Freedenthal, Stacey AU - Wong, Jane L AU - Osman, Augustine AU - Norizuki, Tamami AD - University of Colorado School of Medicine, Denver VA Medical Center, MIRECC, 1055 Clermont St. Denver, CO 80220 e-mail:peter.gutierrez@va.gov Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 53 EP - 61 PB - Taylor & Francis, Philadelphia PA VL - 94 IS - 1 SN - 0022-3891, 0022-3891 KW - Resilience KW - Psychiatric hospitals KW - Reliability KW - Suicide KW - Selfreport KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221434738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+Assessment&rft.atitle=Validation+of+the+Suicide+Resilience+Inventory-25+%28SRI-25%29+in+Adolescent+Psychiatric+Inpatient+Samples&rft.au=Gutierrez%2C+Peter+M%3BFreedenthal%2C+Stacey%3BWong%2C+Jane+L%3BOsman%2C+Augustine%3BNorizuki%2C+Tamami&rft.aulast=Gutierrez&rft.aufirst=Peter&rft.date=2012-01-01&rft.volume=94&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+Assessment&rft.issn=00223891&rft_id=info:doi/10.1080%2F00223891.2011.608755 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JNPABU N1 - SubjectsTermNotLitGenreText - Resilience; Psychiatric hospitals; Reliability; Suicide; Adolescents; Selfreport DO - http://dx.doi.org/10.1080/00223891.2011.608755 ER - TY - JOUR T1 - Changes in Firm Pension Policy: Trends Away from Traditional Defined Benefit Plans AN - 1151042795; 2011-297973 AB - In light of the recent concerns regarding the solvency of Social Security's Old-Age, Survivors and Disability Insurance (OASDI), private pensions may play an increasingly important role in retirement welfare of US retirees. However, the private pension landscape has evolved in ways that may result in lower private pension wealth for retirees. One recent such phenomenon involves the conversion of traditional defined benefit pension plans to cash balance plans, which results in lower pension benefits for many workers. In this study, I investigated how characteristics of the firm's workforce influenced whether the firm converted their traditional pension plan to a cash balance plan and how these characteristics related to the firm's pension plan policy more generally. Using the Longitudinal Employer-Household Data and pension plan data from the Department of Labor/Internal Revenue Service and the Pension Benefit Guaranty Corporation, I found little evidence of workforce age distribution effects on the likelihood of DB plan conversion to a cash balance plan in the 1990s. More generally, I consistently found positive associations between firms with older and more female workforces and defined contribution plans during the same time. Adapted from the source document. JF - Journal of Labor Research AU - Kapinos, Kandice AD - Center for Chronic Disease Outcomes Research, Department of Veterans Affairs Medical Center Kandice.Kapinos@va.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 91 EP - 103 PB - Springer, New York NY VL - 33 IS - 1 SN - 0195-3613, 0195-3613 KW - Social conditions and policy - Social policy and social development KW - Population groups, population policy, and demographics - Demography and census KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Economic conditions and policy - Property and wealth KW - Banking and public and private finance - Public finance KW - Business and service sector - Insurance KW - Health conditions and policy - Health and health policy KW - Labor conditions and policy - Work and labor KW - Labor conditions and policy - Employment and labor supply KW - Social conditions and policy - Associations and meetings KW - United States KW - Retirement KW - Labor KW - Social insurance KW - Pension benefit guaranty corporation KW - Retirees KW - Labor policy KW - Disability insurance KW - Pensions KW - Associations KW - Defined benefit plans KW - Wealth KW - Revenue KW - Benefits KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1151042795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Labor+Research&rft.atitle=Changes+in+Firm+Pension+Policy%3A+Trends+Away+from+Traditional+Defined+Benefit+Plans&rft.au=Kapinos%2C+Kandice&rft.aulast=Kapinos&rft.aufirst=Kandice&rft.date=2012-01-01&rft.volume=33&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Journal+of+Labor+Research&rft.issn=01953613&rft_id=info:doi/10.1007%2Fs12122-011-9126-5 LA - English DB - PAIS Index N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JLRED6 N1 - SubjectsTermNotLitGenreText - Labor policy; Pensions; Retirees; Benefits; Defined benefit plans; Wealth; Pension benefit guaranty corporation; United States; Revenue; Disability insurance; Labor; Social insurance; Retirement; Associations DO - http://dx.doi.org/10.1007/s12122-011-9126-5 ER - TY - JOUR T1 - How do components of evidence-based psychological treatment cluster in practice? A survey and cluster analysis AN - 1081895502; 201224365 AB - Evidence-based psychological treatments (EBPTs) are clusters of interventions, but it is unclear how providers actually implement these clusters in practice. A disaggregated measure of EBPTs was developed to characterize clinicians' component-level evidence-based practices and to examine relationships among these practices. Survey items captured components of evidence-based treatments based on treatment integrity measures. The Web-based survey was conducted with 75 U.S. Department of Veterans Affairs (VA) substance use disorder (SUD) practitioners and 149 non-VA community-based SUD practitioners. Clinician's self-designated treatment orientations were positively related to their endorsement of those EBPT components; however, clinicians used components from a variety of EBPTs. Hierarchical cluster analysis indicated that clinicians combined and organized interventions from cognitive-behavioral therapy, the community reinforcement approach, motivational interviewing, structured family and couples therapy, 12-step facilitation, and contingency management into clusters including empathy and support, treatment engagement and activation, abstinence initiation, and recovery maintenance. Understanding how clinicians use EBPT components may lead to improved evidence-based practice dissemination and implementation. [Copyright Elsevier Inc.] JF - Journal of Substance Abuse Treatment AU - Gifford, Elizabeth V AU - Tavakoli, Sara AU - Weingardt, Kenneth R AU - Finney, John W AU - Pierson, Heather M AU - Rosen, Craig S AU - Hagedom, Hildi J AU - Cook, Joan M AU - Curran, Geoff M AD - VA Palo Alto Health Care System, Center for Health Care Evaluation, 795 Willow Road, Menlo Park, CA 94025, USA Tel.: +1 530 583 3183, Fax: +1 650 617 2736 elizabeth.gifford@va.gov Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 45 EP - 55 PB - Elsevier, New York NY VL - 42 IS - 1 SN - 0740-5472, 0740-5472 KW - Implementation, Evidence-based practices, Psychotherapy, Substance use disorders KW - Cognitive behaviour therapy KW - Interventions KW - Substance abuse disorders KW - Psychological intervention KW - Twelve step model KW - Dissemination KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081895502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=How+do+components+of+evidence-based+psychological+treatment+cluster+in+practice%3F+A+survey+and+cluster+analysis&rft.au=Gifford%2C+Elizabeth+V%3BTavakoli%2C+Sara%3BWeingardt%2C+Kenneth+R%3BFinney%2C+John+W%3BPierson%2C+Heather+M%3BRosen%2C+Craig+S%3BHagedom%2C+Hildi+J%3BCook%2C+Joan+M%3BCurran%2C+Geoff+M&rft.aulast=Gifford&rft.aufirst=Elizabeth&rft.date=2012-01-01&rft.volume=42&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/10.1016%2Fj.jsat.2011.07.008 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Substance abuse disorders; Psychological intervention; Cognitive behaviour therapy; Dissemination; Twelve step model; Interventions DO - http://dx.doi.org/10.1016/j.jsat.2011.07.008 ER - TY - JOUR T1 - Examining Gender Differences in the Relationship Between Dating Violence Victimization and Anger in College Students AN - 1081862062; 201237575 AB - It has been well established that dating violence victimization is associated with various mental health problems. Relatively, little is known about similarities and differences between mental health correlates of dating violence victimization for males and females. We examined the associations between physical and psychological victimization experiences and measures of anger in a sample of 200 male and female undergraduates. Results suggest that men's victimization was more strongly associated with different forms of anger than women's victimization. Adapted from the source document. JF - Violence and Victims AU - Rutter, Lauren A AU - Weatherill, Robin P AU - Taft, Casey T AU - Orazem, Robert J AD - National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System (116B-4), 150 South Huntington Avenue, Boston, MA 02130-4893 Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 70 EP - 77 PB - Springer Publishing Co., New York NY VL - 27 IS - 1 SN - 0886-6708, 0886-6708 KW - couples, mental health, anger, gender differences, university, dating violence KW - Males KW - Sex Differences KW - Victims KW - College Students KW - Mental Health KW - Females KW - Violence KW - Anger KW - Victimization KW - article KW - 2190: social problems and social welfare; victimology (rape, family violence, & child abuse) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081862062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Violence+and+Victims&rft.atitle=Examining+Gender+Differences+in+the+Relationship+Between+Dating+Violence+Victimization+and+Anger+in+College+Students&rft.au=Rutter%2C+Lauren+A%3BWeatherill%2C+Robin+P%3BTaft%2C+Casey+T%3BOrazem%2C+Robert+J&rft.aulast=Rutter&rft.aufirst=Lauren&rft.date=2012-01-01&rft.volume=27&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Violence+and+Victims&rft.issn=08866708&rft_id=info:doi/10.1891%2F0886-6708.27.1.70 LA - English DB - Sociological Abstracts N1 - Date revised - 2014-02-21 N1 - Number of references - 23 N1 - Last updated - 2016-09-28 N1 - CODEN - VIOVEI N1 - SubjectsTermNotLitGenreText - Victims; Victimization; Sex Differences; Anger; Males; Females; Violence; Mental Health; College Students DO - http://dx.doi.org/10.1891/0886-6708.27.1.70 ER - TY - JOUR T1 - The Role of Bacteria in the Pathogenesis of Ulcerative Colitis AN - 1028027647; 16836354 AB - Factors implicated in the pathophysiology of ulcerative colitis (UC) are an abnormal immune response, defect in intestinal epithelial barrier function, and gut microbiota. Currently, it is unclear whether specific bacterial strains are responsible for the induction of intestinal inflammation, but increased bacterial tissue invasion has been described in affected UC patients. Further, a quantitative and qualitative microbial imbalance in UC, defined as dysbiosis, has been characterized by an increase in Rhodococcus spp. , Shigella spp. , and Escherichia spp. , but a decrease in certain Bacteroides spp. . More specifically, Campylobacter spp. , Enterobacteriae , and enterohepatic Helicobacter were more prevalent in tissue sample from UC patients subjected to molecular detection methods, but not controls. In addition, serologic testing identified Fusobacterim varium as a potential contributor to the intestinal inflammation in UC. Interestingly, in-situ hybridization studies have shown anti-inflammatory Lactobacillus spp. and Pediococcus spp. were absent in samples from subjects affected by UC. Therefore, dysbiosis is a factor in the pathogenesis of UC. JF - Journal of Signal Transduction AU - Sasaki, Maiko AU - Klapproth, Jan-Michael A AD - Division of Digestive Diseases, Atlanta Veterans Administration Medical Center, Emory University, Whitehead Biomedical Research Building, Suite 201, 615 Michael Street, Atlanta, GA 30322, USA, jklappr@emory.edu Y1 - 2012/01// PY - 2012 DA - Jan 2012 PB - Hindawi Publishing Corporation VL - 2012 SN - 2090-1739, 2090-1739 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Digestive tract KW - Immune response KW - Inflammation KW - Intestine KW - Ulcerative colitis KW - Pediococcus KW - Helicobacter KW - Bacteroides KW - Campylobacter KW - Shigella KW - Rhodococcus KW - Lactobacillus KW - Escherichia KW - J 02350:Immunology KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028027647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Signal+Transduction&rft.atitle=The+Role+of+Bacteria+in+the+Pathogenesis+of+Ulcerative+Colitis&rft.au=Sasaki%2C+Maiko%3BKlapproth%2C+Jan-Michael+A&rft.aulast=Sasaki&rft.aufirst=Maiko&rft.date=2012-01-01&rft.volume=2012&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Signal+Transduction&rft.issn=20901739&rft_id=info:doi/10.1155%2F2012%2F704953 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Number of references - 54 N1 - Last updated - 2013-04-19 N1 - SubjectsTermNotLitGenreText - Digestive tract; Ulcerative colitis; Intestine; Immune response; Inflammation; Rhodococcus; Pediococcus; Lactobacillus; Helicobacter; Bacteroides; Campylobacter; Shigella; Escherichia DO - http://dx.doi.org/10.1155/2012/704953 ER - TY - JOUR T1 - Association between Alcohol Screening Results and Hospitalizations for Trauma in Veterans Affairs Outpatients AN - 1018377657; 201212212 AB - Background: Alcohol consumption is a risk factor for traumatic injury, but it is unknown whether responses to alcohol screening questionnaires administered routinely in primary care are associated with subsequent hospitalization for traumatic injury. Objective: We evaluated the association between alcohol screening scores and the risk for subsequent hospitalizations for trauma among Veterans Affairs (VA) general medicine patients. Method: This study included VA outpatients (n = 32,623) at seven sites who returned mailed surveys (1997-1999). Alcohol Use Disorders Identification Test Consumption (AUDIT-C) scores grouped patients into six drinking categories representing nondrinkers, screen-negative drinkers, and drinkers who screened positive for mild, moderate, severe, and very severe alcohol misuse (scores 0, 1-3, 4-5, 6-7, 8-9, 10-12, respectively). VA administrative and Medicare data identified primary discharge diagnoses for trauma. Cox proportional hazard models were used to estimate the risk of trauma-related hospitalization for each drinking group adjusted for demographics, smoking, and comorbidity. Results: Compared with screen-negative drinkers, patients with severe and very severe alcohol misuse (AUDIT-C 8-9 and =10) were at significantly increased risk for trauma-related hospitalization over the follow-up period (adjusted hazard ratios AUDIT-C: 8-9 2.06, 95% confidence interval (CI) 1.31- 3.24 and AUDIT-C=10 2.13, 95% CI 1.32-3.42). Conclusions: Patients with severe and very severe alcohol misuse had a twofold increased risk of hospital admission for trauma compared to drinkers without alcohol misuse. Scientific Significance: Alcohol screening scores could be used to provide feedback to patients regarding risk of trauma-related hospitalization. Findings could be used by providers during brief alcohol-related interventions with patients with alcohol misuse. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Williams, Emily C AU - Bryson, Chris L AU - Sun, Haili AU - Chew, Ryan B AU - Chew, Lisa D AU - Blough, David K AU - Au, David H AU - Bradley, Katherine A AD - Health Services Research & Development (HSR&D) Northwest Center of Excellence, VA Puget Sound Health Care System emily.williams3@va.gov Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 73 EP - 80 PB - Taylor & Francis Inc., Philadelphia, PA VL - 38 IS - 1 SN - 0095-2990, 0095-2990 KW - alcohol screening, trauma, AUDIT-C, brief alcohol counseling intervention KW - Hazards KW - Alcohol consumption KW - Screening KW - Injuries KW - Hospitalization KW - Alcohol abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018377657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Association+between+Alcohol+Screening+Results+and+Hospitalizations+for+Trauma+in+Veterans+Affairs+Outpatients&rft.au=Williams%2C+Emily+C%3BBryson%2C+Chris+L%3BSun%2C+Haili%3BChew%2C+Ryan+B%3BChew%2C+Lisa+D%3BBlough%2C+David+K%3BAu%2C+David+H%3BBradley%2C+Katherine+A&rft.aulast=Williams&rft.aufirst=Emily&rft.date=2012-01-01&rft.volume=38&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.3109%2F00952990.2011.600392 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Hospitalization; Alcohol abuse; Screening; Alcohol consumption; Injuries; Hazards DO - http://dx.doi.org/10.3109/00952990.2011.600392 ER - TY - JOUR T1 - Longer Length of Stay Is Not Associated with Better Outcomes in VHA's Substance Abuse Residential Rehabilitation Treatment Programs AN - 1018376596; 201210796 AB - Are longer stays in Veterans Health Administration (VHA) substance abuse residential rehabilitation treatment programs (SARRTPs) associated with better substance-related outcomes? To investigate, up to 50 new patients were randomly selected from each of 28 randomly selected programs (1,307 patients). The goal was to examine if patient and program average length of stay (ALOS) were associated with improvement on Addiction Severity Index (ASI) Alcohol and Drug composite scores in covariate-adjusted, multi-level regression models. Patients in programs with ALOS greater than 90 days tended to have more mental health treatment prior to the index episode and less severe substance-related symptoms, but more homelessness. At follow-up, programs longer than 90 days had the least improvement in the ASI Alcohol composite and significantly less improvement than programs with ALOSs of 15 to 30 and 31 to 45 days (both p<0.05). Therefore, in VHA SARRTPs, ALOS greater than 90 days cannot be justified by the substance use disorder severity of the patients served or the magnitude of the clinical improvement observed. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Harris, Alex H S AU - Kivlahan, Daniel AU - Barnett, Paul G AU - Finney, John W AD - Center for Health Care Evaluation, VA Palo Alto Health Care System, Stanford University School of Medicine, 795 Willow Road (MC152), Menlo Park, CA, 94025, USA alexander.harris2@va.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 68 EP - 79 PB - Springer, US VL - 39 IS - 1 SN - 1094-3412, 1094-3412 KW - Severity KW - Mental health services KW - Residential care KW - Length of stay KW - Treatment methods KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018376596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Longer+Length+of+Stay+Is+Not+Associated+with+Better+Outcomes+in+VHA%27s+Substance+Abuse+Residential+Rehabilitation+Treatment+Programs&rft.au=Harris%2C+Alex+H+S%3BKivlahan%2C+Daniel%3BBarnett%2C+Paul+G%3BFinney%2C+John+W&rft.aulast=Harris&rft.aufirst=Alex+H&rft.date=2012-01-01&rft.volume=39&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-011-9250-2 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Substance abuse; Treatment methods; Mental health services; Length of stay; Severity; Residential care DO - http://dx.doi.org/10.1007/s11414-011-9250-2 ER - TY - JOUR T1 - Osteoporotic fracture risk associated with cumulative exposure to tenofovir and other antiretroviral agents AN - 1014109316; 16670318 AB - Background: Whereas tenofovir (TDF) exposure has been associated with decreased bone density, it remains unclear whether it is associated with increased risk of osteoporotic fractures. Methods: Patients with any osteoporotic fracture (defined as wrist, vertebral or hip fracture) occurring after HIV diagnosis were identified by International Classification of Diseases - 9th Revision (ICD-9) code in the Veterans Affairs' Clinical Case Registry from 1988 to 2009. Osteoporotic fracture risk associated with cumulative exposure to TDF and other antiretrovirals was examined in univariate analysis and multivariate model 1 (MV1 - controlling for race, age, tobacco use, diabetes, body mass index, and hepatitis C status) and model 2 (MV2 - controlling for MV1 variables + concomitant antiretroviral exposures). Results: Among 56 660 patients evaluated, TDF exposure (total 46 062 person-years) was associated with an osteoporotic fracture hazard ratio of 1.080 [95% confidence interval (Cl) 1.02-1.15, P < 0.001] in univariate analysis, 1.06 (0.99-1.12) in MV1 and 1.06 (0.99-1.14) in MV2. Among patients entering the cohort in the highly active antiretroviral therapy (HAART) era (n = 32 439), TDF exposure was associated with a yearly hazard ratio for osteoporotic fracture of 1.16 (95% CI 1.08-1.24, P < 0.001) in univariate model, 1.13 (1.05-1.21, P = 0.001) in MV1 and 1.12 (1.03-1.21, P = 0.011) in MV2. Boosted protease inhibitor exposure was associated with hazard ratio of 1.11 (1.05-1.18, P = 0.001) in univariate model, 1.08 (1.01-1.15, P = 0.026) in MV1 and 1.05 (0.97-1.13, P= 0.237) in MV2. Among protease inhibitors, lopinavir/ritonavir (LPV/RTV) had an osteoporotic fracture hazard ratio of 1.09 (Cl 1.00-1.20, P = 0.051) in MV2. Conclusion: Cumulative exposure to TDF and, among protease inhibitors, LPV/RTV was independently predictive of increased risk of osteoporotic fracture in the HAART era. JF - AIDS AU - Bedimo, R AU - Maalouf, N M AU - Zhang, S AU - Drechsler, H AU - Tebas, P AD - VA North Texas Healthcare System, 4500 South Lancaster Road, 111-D Dallas, TX, USA, Roger.Bedimo@va.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 825 EP - 831 VL - 26 IS - 7 SN - 0269-9370, 0269-9370 KW - Risk Abstracts; Toxicology Abstracts; Calcium & Calcified Tissue Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Risk assessment KW - Acquired immune deficiency syndrome KW - Age KW - Wrist KW - Bone density KW - tenofovir KW - Vertebrae KW - Models KW - Lopinavir KW - Antiviral agents KW - Classification KW - antiretroviral agents KW - Tobacco KW - Hepatitis C KW - Races KW - proteinase inhibitors KW - Proteinase inhibitors KW - Fractures KW - Osteoporosis KW - Hepatitis KW - Diabetes mellitus KW - hip fracture KW - Human immunodeficiency virus KW - highly active antiretroviral therapy KW - Ritonavir KW - Body mass index KW - Hip KW - V 22360:AIDS and HIV KW - X 24380:Social Poisons & Drug Abuse KW - R2 23060:Medical and environmental health KW - F 06930:Autoimmunity KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1014109316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Osteoporotic+fracture+risk+associated+with+cumulative+exposure+to+tenofovir+and+other+antiretroviral+agents&rft.au=Bedimo%2C+R%3BMaalouf%2C+N+M%3BZhang%2C+S%3BDrechsler%2C+H%3BTebas%2C+P&rft.aulast=Bedimo&rft.aufirst=R&rft.date=2012-01-01&rft.volume=26&rft.issue=7&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0b013e32835192ae LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Risk assessment; Age; Wrist; Proteinase inhibitors; Fractures; Bone density; Osteoporosis; tenofovir; Vertebrae; Models; Diabetes mellitus; Classification; Antiviral agents; Lopinavir; Ritonavir; highly active antiretroviral therapy; antiretroviral agents; Tobacco; Hepatitis C; Body mass index; Races; Hip; Hepatitis; hip fracture; Acquired immune deficiency syndrome; proteinase inhibitors; Human immunodeficiency virus DO - http://dx.doi.org/10.1097/QAD.0b013e32835192ae ER - TY - JOUR T1 - State of the art; microbiology in health and disease. Intestinal bacterial flora in autism AN - 918060938; 16187510 AB - Autism of the regressive variety is selected as an example of the importance of intestinal bacterial microflora in disease other than classical infection. Our studies have indicated that intestinal bacteria play a role in this disease since it responds to oral vancomycin, a drug that is not absorbed from the GI tract. Pyrosequencing studies document an abnormal gut microflora in regressive autism subjects as compared to controls. Finally, we present preliminary evidence suggesting that Desulfovibrio may play a key role in this disease. JF - Anaerobe AU - Finegold, Sydney M AD - Veterans Administration Medical Center Staff Physician, Infectious Diseases Section (111F), Los Angeles, CA 90073, United States, sidfinegol@aol.com Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 367 EP - 368 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 17 IS - 6 SN - 1075-9964, 1075-9964 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Autism KW - Digestive tract KW - Drugs KW - Gastrointestinal tract KW - Infection KW - Intestinal microflora KW - Intestine KW - Microflora KW - Vancomycin KW - Bacteria KW - Desulfovibrio KW - A 01490:Miscellaneous KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918060938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=State+of+the+art%3B+microbiology+in+health+and+disease.+Intestinal+bacterial+flora+in+autism&rft.au=Finegold%2C+Sydney+M&rft.aulast=Finegold&rft.aufirst=Sydney&rft.date=2011-12-01&rft.volume=17&rft.issue=6&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=10759964&rft_id=info:doi/10.1016%2Fj.anaerobe.2011.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Intestinal microflora; Digestive tract; Microflora; Intestine; Vancomycin; Gastrointestinal tract; Infection; Drugs; Autism; Bacteria; Desulfovibrio DO - http://dx.doi.org/10.1016/j.anaerobe.2011.03.007 ER - TY - JOUR T1 - Using statistical text mining to supplement the development of an ontology AN - 918052720; 16144106 AB - Statistical text mining was used to supplement efforts to develop a clinical vocabulary for post-traumatic stress disorder (PTSD) in the VA. A set of outpatient progress notes was collected for a cohort of 405 unique veterans with PTSD and a comparison group of 392 with other psychological conditions at one VA hospital. Two methods were employed: (1) "multi-model term scoring" used stepwise logistic regression to develop 21 separate models by varying three frequency weight and seven term weight options and (2) "iterative term refinement" which used a standard stop list followed by clinical review to eliminate non-clinical terms and terms not related to PTSD. Combined results of the two methods were reviewed by two clinicians resulting in 226 unique PTSD related terms. Results of the statistical text mining methods were compared with ongoing efforts to identify terms based on literature review, focus groups with clinicians treating PTSD and review of an existing vocabulary, lending support to the contributions of the STM analyses. JF - Journal of Biomedical Informatics AU - Luther, Stephen AU - Berndt, Donald AU - Finch, Dezon AU - Richardson, Matthew AU - Hickling, Edward AU - Hickam, David AD - Consortium for Healthcare Informatics Research (CHIR), steve.luther@med.va.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - S86 EP - S93 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 44 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts KW - Text mining KW - Controlled vocabulary KW - Ontology development KW - Post-traumatic stress disorder (PTSD) KW - Statistics KW - Literature reviews KW - Regression analysis KW - Bioinformatics KW - Post-traumatic stress disorder KW - Short term memory KW - Hospitals KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918052720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=Using+statistical+text+mining+to+supplement+the+development+of+an+ontology&rft.au=Luther%2C+Stephen%3BBerndt%2C+Donald%3BFinch%2C+Dezon%3BRichardson%2C+Matthew%3BHickling%2C+Edward%3BHickam%2C+David&rft.aulast=Luther&rft.aufirst=Stephen&rft.date=2011-12-01&rft.volume=44&rft.issue=&rft.spage=S86&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2011.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Statistics; Literature reviews; Regression analysis; Bioinformatics; Short term memory; Post-traumatic stress disorder; Models; Hospitals DO - http://dx.doi.org/10.1016/j.jbi.2011.11.001 ER - TY - JOUR T1 - Exercise Training in Obese Older Adults Prevents Increase in Bone Turnover and Attenuates Decrease in Hip Bone Mineral Density Induced by Weight Loss Despite Decline in Bone-Active Hormones AN - 911163159; 16107174 AB - Weight loss therapy to improve health in obese older adults is controversial because it causes further bone loss. Therefore, it is recommended that weight loss therapy should include an intervention such as exercise training (ET) to minimize bone loss. The purpose of this study was to determine the independent and combined effects of weight loss and ET on bone metabolism in relation to bone mineral density (BMD) in obese older adults. One-hundred-seven older (age > 65 years) obese (body mass index [BMI] greater than or equal to 30 kg/m super(2)) adults were randomly assigned to a control group, diet group, exercise group, and diet-exercise group for 1 year. Body weight decreased in the diet (-9.6%) and diet-exercise (-9.4%) groups, not in the exercise (-1%) and control (-0.2%) groups (between-group p < 0.001). However, despite comparable weight loss, bone loss at the total hip was relatively less in the diet-exercise group (-1.1%) than in the diet group (-2.6%), whereas BMD increased in the exercise group (1.5%) (between-group p < 0.001). Serum C-terminal telopeptide (CTX) and osteocalcin concentrations increased in the diet group (31% and 24%, respectively), whereas they decreased in the exercise group (-13% and -15%, respectively) (between-group p < 0.001). In contrast, similar to the control group, serum CTX and osteocalcin concentrations did not change in the diet-exercise group. Serum procollagen propeptide concentrations decreased in the exercise group (-15%) compared with the diet group (9%) (p = 0.04). Serum leptin and estradiol concentrations decreased in the diet (-25% and -15%, respectively) and diet-exercise (-38% and -13%, respectively) groups, not in the exercise and control groups (between-group p = 0.001). Multivariate analyses revealed that changes in lean body mass ( beta = 0.33), serum osteocalcin ( beta = -0.24), and one-repetition maximum (1-RM) strength ( beta = 0.23) were independent predictors of changes in hip BMD (all p < 0.05). In conclusion, the addition of ET to weight loss therapy among obese older adults prevents weight loss-induced increase in bone turnover and attenuates weight loss-induced reduction in hip BMD despite weight loss-induced decrease in bone-active hormones. JF - Journal of Bone and Mineral Research AU - Shah, K AU - Armamento-Villareal, R AU - Parimi, N AU - Chode, S AU - Sinacore AU - Hilton, T N AU - Napoli, N AU - Qualls, C AU - Villareal, D T AD - New Mexico VA Health Care System, Geriatrics (111K), 1501 San Pedro Drive SE, Albuquerque, NM 87111, USA, dennis.villareal@va.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 2851 EP - 2859 VL - 26 IS - 12 SN - 0884-0431, 0884-0431 KW - Physical Education Index; Calcium & Calcified Tissue Abstracts KW - procollagen KW - Bones KW - Adults KW - Hormones KW - Collagen KW - Bone mineral density KW - Body weight KW - Multivariate analysis KW - Geriatrics KW - Lean body mass KW - Diets KW - Obesity KW - Weight control KW - Osteocalcin KW - Gerontology KW - Exercise KW - Estradiol KW - Physical training KW - Leptin KW - Blood KW - Bone loss KW - Bone turnover KW - Diet KW - Body mass index KW - Hip KW - T 2025:Bone and Bone Diseases KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911163159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bone+and+Mineral+Research&rft.atitle=Exercise+Training+in+Obese+Older+Adults+Prevents+Increase+in+Bone+Turnover+and+Attenuates+Decrease+in+Hip+Bone+Mineral+Density+Induced+by+Weight+Loss+Despite+Decline+in+Bone-Active+Hormones&rft.au=Shah%2C+K%3BArmamento-Villareal%2C+R%3BParimi%2C+N%3BChode%2C+S%3BSinacore%3BHilton%2C+T+N%3BNapoli%2C+N%3BQualls%2C+C%3BVillareal%2C+D+T&rft.aulast=Shah&rft.aufirst=K&rft.date=2011-12-01&rft.volume=26&rft.issue=12&rft.spage=2851&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/10.1002%2Fjbmr.475 LA - English DB - Physical Education Index N1 - Date revised - 2011-12-01 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - Blood; Obesity; Bones; Weight control; Bone mineral density; Gerontology; Adults; Diet; Exercise; Diets; procollagen; Osteocalcin; Hormones; Estradiol; Physical training; Collagen; Leptin; Body weight; Multivariate analysis; Bone loss; Geriatrics; Bone turnover; Body mass index; Lean body mass; Hip DO - http://dx.doi.org/10.1002/jbmr.475 ER - TY - JOUR T1 - PDE3 inhibition in dilated cardiomyopathy. AN - 906560700; 21962613 AB - In dilated cardiomyopathy, a condition characterized by chamber enlargement and reduced myocardial contractility, decreases in β-adrenergic receptor density and increases in Gαi and β-adrenergic receptor kinase activities attenuate the stimulation of adenylyl cyclase in response to catecholamines. PDE3 inhibitors have been used to 'overcome' the reduction in cAMP generation by blocking cAMP hydrolysis. These drugs increase contractility in the short-term, but long-term administration leads to an increase in mortality that correlates with an increase in sudden cardiac death. Whether separate mechanisms account for these beneficial and harmful effects, and, if so, whether PDE3 can be targeted so as to increase contractility without increasing mortality are questions that remain unanswered. Published by Elsevier Ltd. JF - Current opinion in pharmacology AU - Movsesian, Matthew AU - Wever-Pinzon, Omar AU - Vandeput, Fabrice AD - Cardiology Section, VA Salt Lake City Health Care System, and Departments of Internal Medicine (Cardiology) and Pharmacology & Toxicology, University of Utah, Salt Lake City, UT, USA. matthew.movsesian@va.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 707 EP - 713 VL - 11 IS - 6 KW - Phosphodiesterase 3 Inhibitors KW - 0 KW - Cyclic AMP KW - E0399OZS9N KW - Cyclic Nucleotide Phosphodiesterases, Type 3 KW - EC 3.1.4.17 KW - Index Medicus KW - Animals KW - Humans KW - Cyclic Nucleotide Phosphodiesterases, Type 3 -- metabolism KW - Cyclic AMP -- antagonists & inhibitors KW - Second Messenger Systems -- drug effects KW - Myocardium -- enzymology KW - Heart -- drug effects KW - Myocardial Contraction -- drug effects KW - Cyclic AMP -- physiology KW - Myocardium -- metabolism KW - Heart -- physiopathology KW - Cyclic Nucleotide Phosphodiesterases, Type 3 -- chemistry KW - Phosphodiesterase 3 Inhibitors -- adverse effects KW - Cardiomyopathy, Dilated -- drug therapy KW - Phosphodiesterase 3 Inhibitors -- therapeutic use KW - Phosphodiesterase 3 Inhibitors -- pharmacology KW - Cardiomyopathy, Dilated -- physiopathology KW - Molecular Targeted Therapy KW - Cardiomyopathy, Dilated -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/906560700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+pharmacology&rft.atitle=PDE3+inhibition+in+dilated+cardiomyopathy.&rft.au=Movsesian%2C+Matthew%3BWever-Pinzon%2C+Omar%3BVandeput%2C+Fabrice&rft.aulast=Movsesian&rft.aufirst=Matthew&rft.date=2011-12-01&rft.volume=11&rft.issue=6&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+pharmacology&rft.issn=1471-4973&rft_id=info:doi/10.1016%2Fj.coph.2011.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-23 N1 - Date created - 2011-11-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2009 May 1;284(18):12339-48 [19261611] J Pharmacol Exp Ther. 2009 Sep;330(3):884-91 [19546307] N Engl J Med. 2011 Jan 6;364(1):11-21 [21073363] Basic Res Cardiol. 2011 Mar;106(2):249-62 [21161247] J Biol Chem. 2002 Oct 11;277(41):38072-8 [12154085] Lancet. 2003 Jul 5;362(9377):7-13 [12853193] J Clin Invest. 2004 Mar;113(5):727-36 [14991071] Chest. 2004 Apr;125(4):1198-204 [15078725] FASEB J. 2004 Aug;18(11):1312-4 [15180962] J Mol Cell Cardiol. 2004 Sep;37(3):691-8 [15350842] N Engl J Med. 1978 Dec 21;299(25):1373-7 [714115] N Engl J Med. 1982 Jul 22;307(4):205-11 [6283349] Circulation. 1983 May;67(5):1065-70 [6831672] J Am Coll Cardiol. 1983 Aug;2(2):327-31 [6863765] N Engl J Med. 1983 Sep 29;309(13):748-56 [6888453] Circulation. 1984 Dec;70(6):1030-7 [6499142] J Clin Invest. 1985 Feb;75(2):643-9 [3973022] J Am Coll Cardiol. 1986 May;7(5):1107-13 [3958369] Circulation. 1986 Aug;74(2):367-73 [3731427] Circ Res. 1986 Sep;59(3):297-309 [2876788] Circulation. 1987 Feb;75(2):331-9 [2433073] J Clin Invest. 1988 Jul;82(1):189-97 [2839545] Lancet. 1988 Oct 22;2(8617):936-7 [2902384] J Cardiovasc Pharmacol. 1989 Jul;14(1):171-3 [2475709] J Biochem. 1989 Nov;106(5):872-7 [2613695] Am Heart J. 1991 Jun;121(6 Pt 2):1956-64 [2035427] J Clin Invest. 1991 Jul;88(1):15-9 [1647414] N Engl J Med. 1991 Aug 1;325(5):293-302 [2057034] N Engl J Med. 1991 Aug 1;325(5):303-10 [2057035] Circulation. 1992 Mar;85(3):1046-55 [1311223] Circulation. 1993 Feb;87(2):454-63 [8381058] Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10135-9 [7694283] Circ Res. 1994 Feb;74(2):206-13 [8293560] Cardiovasc Res. 1994 Nov;28(11):1713-9 [7842467] Chest. 1995 Dec;108(6):1524-32 [7497755] Am J Med Sci. 1996 Jun;311(6):286-91 [8659556] Am Heart J. 1996 Oct;132(4):805-8 [8831370] Am Heart J. 1998 Jan;135(1):121-9 [9453531] Physiol Rev. 1998 Oct;78(4):921-47 [9790566] Cell. 1999 Oct 29;99(3):313-22 [10555147] Circulation. 2000 May 9;101(18):2193-9 [10801761] J Biol Chem. 2000 Dec 8;275(49):38749-61 [10952971] N Engl J Med. 2001 Dec 6;345(23):1667-75 [11759645] JAMA. 2002 Mar 27;287(12):1541-7 [11911756] Nat Med. 2002 Aug;8(8):864-71 [12134142] J Biol Chem. 2005 Nov 25;280(47):39168-74 [16172121] EMBO J. 2006 Dec 13;25(24):5716-25 [17124499] Circ Res. 2007 Mar 2;100(4):489-501 [17332439] Cell Signal. 2007 Aug;19(8):1765-71 [17482796] J Biol Chem. 2007 Nov 9;282(45):32749-57 [17726023] Circulation. 2008 May 27;117(21):e350-408 [18483207] Cardiovasc Res. 2009 Feb 15;81(3):465-73 [18779231] J Cardiovasc Pharmacol. 2009 Feb;53(2):157-61 [19188832] Circulation. 2009 Mar 10;119(9):1241-52 [19237664] Circulation. 2009 Apr 14;119(14):1977-2016 [19324967] Circulation. 1999 Aug 31;100(9):974-80 [10468529] Cochrane Database Syst Rev. 2005;(1):CD002230 [15674893] Circulation. 2005 May 17;111(19):2469-76 [15867171] Cardiovasc Res. 2005 Sep 1;67(4):678-88 [15927173] Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14771-6 [16186489] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.coph.2011.09.001 ER - TY - JOUR T1 - The psychological impact of deployment on OEF/OIF healthcare providers AN - 1611634738; 20764860 AB - The psychological impact of military experience on healthcare providers has received little attention to date. The 2005 Department of Defense Survey of Health Related Behaviors Among Active Duty Personnel was used as a secondary data source, and deployed healthcare officers and healthcare specialists were identified and compared to deployed non-healthcare officers and enlisted personnel: 6,116 respondents were surveyed. Findings revealed clinically significant psychological distress among deployed military healthcare provider respondents including posttraumatic stress symptoms, depression, anxiety, and adverse psychosocial impact, more prominent in the deployed healthcare specialist group. Based upon findings, possible factors for resilience and increased risk, as well as potential intervention needs in this healthcare provider group of service members are offered. Implications for future prospective studies are suggested. JF - Journal of Traumatic Stress AU - Hickling, Edward J AU - Gibbons, Susanne AU - Barnett, Scott D AU - Watts, Dorraine AD - Uniformed Services University, Graduate School of Nursing., Edward.hickling@va.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 726 EP - 734 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 24 IS - 6 SN - 0894-9867, 0894-9867 KW - Risk Abstracts KW - Depression KW - Health care KW - Psychology KW - Risk factors KW - Stress KW - Intervention KW - Military KW - Medical personnel KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1611634738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Traumatic+Stress&rft.atitle=The+psychological+impact+of+deployment+on+OEF%2FOIF+healthcare+providers&rft.au=Hickling%2C+Edward+J%3BGibbons%2C+Susanne%3BBarnett%2C+Scott+D%3BWatts%2C+Dorraine&rft.aulast=Hickling&rft.aufirst=Edward&rft.date=2011-12-01&rft.volume=24&rft.issue=6&rft.spage=726&rft.isbn=&rft.btitle=&rft.title=Journal+of+Traumatic+Stress&rft.issn=08949867&rft_id=info:doi/10.1002%2Fjts.20703 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-10-01 N1 - Last updated - 2014-10-30 N1 - SubjectsTermNotLitGenreText - Depression; Health care; Psychology; Risk factors; Intervention; Stress; Military; Medical personnel DO - http://dx.doi.org/10.1002/jts.20703 ER - TY - JOUR T1 - Ethanol metabolism activates cell cycle checkpoint kinase, Chk2 AN - 1458533161; 16071223 AB - Chronic ethanol abuse results in hepatocyte injury and impairs hepatocyte replication. We have previously shown that ethanol metabolism results in cell cycle arrest at the G2/M transition, which is partially mediated by inhibitory phosphorylation of the cyclin-dependent kinase, Cdc2. To further delineate the mechanisms by which ethanol metabolism mediates this G2/M arrest, we investigated the involvement of upstream regulators of Cdc2 activity. Cdc2 is activated by the phosphatase Cdc25C. The activity of Cdc25C can, in turn, be regulated by the checkpoint kinase, Chk2, which is regulated by the kinase ataxia telangiectasia mutated (ATM). To investigate the involvement of the regulators of Cdc2 activity, VA-13 cells, which are Hep G2 cells modified to efficiently express alcohol dehydrogenase, were cultured in the presence or absence of 25 mM ethanol. Immunoblots were performed to determine the effects of ethanol metabolism on the activation of Cdc25C, Chk2, and ATM. Ethanol metabolism increased the active forms of ATM and Chk2, as well as the phosphorylated form of Cdc25C. Additionally, inhibition of ATM resulted in approximately 50% of the cells being rescued from the G2/M cell cycle arrest and ameliorated the inhibitory phosphorylation of Cdc2. Our findings demonstrated that ethanol metabolism activates ATM. ATM can activate the checkpoint kinase Chk2, resulting in phosphorylation of Cdc25C and ultimately in the accumulation of inactive Cdc2. This may, in part, explain the ethanol metabolism-mediated impairment in hepatocyte replication, which may be important in the initiation and progression of alcoholic liver injury. JF - Alcohol AU - Clemens, Dahn L AU - Schneider, Katrina JMahan AU - Nuss, Robert F AD - Research Service R151, Veterans Administration Medical Center, Omaha, NE 68105, USA, dclemens@unmc.edu Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 785 EP - 793 PB - Elsevier B.V., Box 882 New York NY 10159 United States VL - 45 IS - 8 SN - 0741-8329, 0741-8329 KW - Toxicology Abstracts KW - CHK2 protein KW - Injuries KW - Replication KW - Hepatocytes KW - Cell cycle KW - Alcohol dehydrogenase KW - Alcoholics KW - Abuse KW - Ataxia telangiectasia mutated protein KW - Replication initiation KW - Phosphorylation KW - Cyclin-dependent kinase KW - Liver KW - Metabolism KW - Cdc2 protein KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1458533161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol&rft.atitle=Ethanol+metabolism+activates+cell+cycle+checkpoint+kinase%2C+Chk2&rft.au=Clemens%2C+Dahn+L%3BSchneider%2C+Katrina+JMahan%3BNuss%2C+Robert+F&rft.aulast=Clemens&rft.aufirst=Dahn&rft.date=2011-12-01&rft.volume=45&rft.issue=8&rft.spage=785&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/10.1016%2Fj.alcohol.2011.07.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-11-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - CHK2 protein; Injuries; Hepatocytes; Replication; Cell cycle; Alcohol dehydrogenase; Abuse; Alcoholics; Ataxia telangiectasia mutated protein; Replication initiation; Cyclin-dependent kinase; Phosphorylation; Liver; Metabolism; Ethanol; Cdc2 protein DO - http://dx.doi.org/10.1016/j.alcohol.2011.07.005 ER - TY - JOUR T1 - Is Measured Hearing Aid Benefit Affected by Seeing Baseline Outcome Questionnaire Responses? AN - 1023037200; 201209481 AB - Purpose: To determine whether hearing aid outcome measured by the Hearing Handicap Inventory (HHI) for the Elderly/Adults (Newman, Weinstein, Jacobson, & Hug, 1990; Ventry & Weinstein, 1982) is differentially affected by informed vs. blind administration of the postfitting questionnaire. Method: Participants completed the HHI at their hearing aid evaluation and again at their hearing aid follow-up visit. At follow-up, half received a clean HHI form (blind administration), whereas the remainder responded on their original form (informed administration) and could thus base their follow-up responses on those they gave at the hearing aid evaluation. Adapted from the source document JF - American Journal of Audiology AU - Silverman, ShienPei AU - Cates, Megan AU - Saunders, Gabrielle AD - National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Portland, OR gabrielle.saunders@va.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 90 EP - 99 VL - 20 IS - 2 SN - 1059-0889, 1059-0889 KW - Hearing Therapy (31580) KW - Hearing Aids (31250) KW - article KW - 6811: special education; hearing therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023037200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Audiology&rft.atitle=Is+Measured+Hearing+Aid+Benefit+Affected+by+Seeing+Baseline+Outcome+Questionnaire+Responses%3F&rft.au=Silverman%2C+ShienPei%3BCates%2C+Megan%3BSaunders%2C+Gabrielle&rft.aulast=Silverman&rft.aufirst=ShienPei&rft.date=2011-12-01&rft.volume=20&rft.issue=2&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Audiology&rft.issn=10590889&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJALFZ N1 - SubjectsTermNotLitGenreText - Hearing Aids (31250); Hearing Therapy (31580) ER - TY - JOUR T1 - Cross-Level Bias and Variations in Care AN - 1034813314; 16080511 JF - JAMA: Journal of the American Medical Association AU - Finney, John W AU - Humphreys, Keith AU - Harris, Alex HS AD - Author Affiliations: Center for Health Care Evaluation, VA Palo Alto Health Care System, Menlo Park, California, john.finney@va.gov Y1 - 2011/11/16/ PY - 2011 DA - 2011 Nov 16 SP - 2096 EP - 2097 PB - American Medical Association, 515 N. State St. Chicago IL 60610 United States VL - 306 IS - 19 SN - 0098-7484, 0098-7484 KW - Physical Education Index KW - AMA KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034813314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Cross-Level+Bias+and+Variations+in+Care&rft.au=Finney%2C+John+W%3BHumphreys%2C+Keith%3BHarris%2C+Alex+HS&rft.aulast=Finney&rft.aufirst=John&rft.date=2011-11-16&rft.volume=306&rft.issue=19&rft.spage=2096&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2012-08-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - AMA ER - TY - JOUR T1 - Targeting Cyclin D1 in Non-small Cell Lung Cancer and Mesothelioma Cells by Antisense Oligonucleotides AN - 918063498; 16110677 AB - Background: Cyclin D1 overexpression exists in multiple types of cancer and is a potential chemopreventive or therapeutic target. Materials and Methods: Non-small cell lung cancer and mesothelioma cells were incubated with antisense oligonucleotides (ASO) to cyclin D1 (CD1) and evaluated for effects on cellular proliferation, apoptosis, expression of cell cycle-specific proteins, and protein phosphorylation states. Results: ASO to CD1 inhibited proliferation of non-small lung cancer cells and mesothelioma cells. ASO induced apoptosis as determined by TUNEL assay. Western blot analysis of cell lysate showed that ASO inhibited the de novo synthesis of CD1, CD3, and CDK2 in multiple cell lines. Immunoprecipitation and immunoblotting with phosphoantibodies demonstrated that CD1, CD3, and CDK2 exist in a phosphorylated state. Conclusion: The work demonstrates that non-small cell lung cancer and mesothelioma cells respond to ASO-mediated cellular growth inhibition. These findings make ASO to CD1 attractive as a potential therapeutic for mesothelioma and non-small cell lung cancer. JF - Anticancer Research AU - Saini, S S AU - Klein, MA AD - VA Medical Center, One Veterans' Dr., 111E, Minneapolis, MN 55417, USA, Mark.Klein2@va.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 3683 EP - 3690 VL - 31 IS - 11 SN - 0250-7005, 0250-7005 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Antisense oligonucleotides KW - mesothelioma KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918063498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+Research&rft.atitle=Targeting+Cyclin+D1+in+Non-small+Cell+Lung+Cancer+and+Mesothelioma+Cells+by+Antisense+Oligonucleotides&rft.au=Saini%2C+S+S%3BKlein%2C+MA&rft.aulast=Saini&rft.aufirst=S&rft.date=2011-11-01&rft.volume=31&rft.issue=11&rft.spage=3683&rft.isbn=&rft.btitle=&rft.title=Anticancer+Research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2014-04-03 N1 - SubjectsTermNotLitGenreText - mesothelioma ER - TY - JOUR T1 - Complementary medicine use is not associated with non-adherence to conventional medication in the elderly: A retrospective study AN - 914790458; 201200150 AB - Lack of adherence to medications is a potential cause of hospitalizations, morbidity, and mortality in the elderly. Medication adherence decreases with polypharmacy. Older persons commonly use complementary medicine, therefore complementary medicine use might pose an increase risk of loss of medication adherence with conventional medications, but this has not been previously investigated. A chart review was conducted of 300 patients at least sixty-five years of age who used at least three medications each who attended a university geriatrics clinic in Florida, USA to obtain information about medication adherence and complementary medicine use. However, no association was found between use of at least one complementary medicine and adherence to conventional medications. [Copyright Elsevier Ltd.] JF - Complementary Therapies in Clinical Practice AU - Cherniack, E Paul AD - The Geriatrics Institute, University of Miami Miller School of Medicine, Division of Geriatrics and Gerontology, Miami, FL, USA evan.cherniack@va.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 206 EP - 208 PB - Elsevier Ltd, The Netherlands VL - 17 IS - 4 SN - 1744-3881, 1744-3881 KW - Complementary medicine Adherence Elderly Medication KW - Prescriptions KW - Elderly people KW - Adherence KW - Geriatric clinics KW - Alternative medicine KW - Morbidity-Mortality KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914790458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Complementary+Therapies+in+Clinical+Practice&rft.atitle=Complementary+medicine+use+is+not+associated+with+non-adherence+to+conventional+medication+in+the+elderly%3A+A+retrospective+study&rft.au=Cherniack%2C+E+Paul&rft.aulast=Cherniack&rft.aufirst=E&rft.date=2011-11-01&rft.volume=17&rft.issue=4&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Complementary+Therapies+in+Clinical+Practice&rft.issn=17443881&rft_id=info:doi/10.1016%2Fj.ctcp.2010.11.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Adherence; Alternative medicine; Elderly people; Morbidity-Mortality; Geriatric clinics; Prescriptions DO - http://dx.doi.org/10.1016/j.ctcp.2010.11.005 ER - TY - JOUR T1 - Test of a Conceptual Model of Partner Aggression Among Women Entering Substance Use Disorder Treatment AN - 912922408; 16125246 AB - Objective: Despite extensive intimate partner violence (IPV) among women in substance use disorder treatment, few studies have investigated IPV risk factors within this population. Conceptual models, which have received support in other populations, propose that antisociality and generalized violence, alcohol and drug use, and relationship adjustment may be interrelated pathways that influence IPV The purpose of this study was to test a conceptual model that integrates these individual and relationship pathways to explain IPV among women entering substance use disorder treatment. Method: Women entering substance use disorder treatment (N = 277) who had a male relationship partner completed measures of the following domains about themselves and their male partners: antisociality/generalized violence, heavy alcohol use, drug use, relationship adjustment, and psychological and physical IPV. Results: Structural equation modeling analyses showed that the antisociality/generalized violence of each partner had direct and indirect effects on IPV Each partner's antisociality/generalized violence was directly related to her or his physical IPV Female antisociality/generalized violence was indirectly related to female physical IPV via female drug use and female psychological IPV Male antisociality/generalized violence was indirectly associated with male physical IPV via male drinking, relationship adjustment, and male psychological IPV A reciprocal relationship was found between partners' psychological IPV but not physical IPV When accounting for other individual and relational IPV predictors, male partners' physical IPV influenced women's physical IPV, but women's physical IPV did not influence their male partner's physical IPV Conclusions: Both partners' antisociality/generalized violence, substance use, and overall relationship adjustment are important in understanding IPV among women entering substance use disorder treatment. JF - Journal of Studies on Alcohol and Drugs AU - Schumm, JA AU - O'Farrell, T J AU - Murphy, C M AU - Murphy, M AU - Muchowski, P AD - Cincinnati VA Medical Center, PTSD and Anxiety Disorders Division, 1000 South Fort Thomas Avenue, Fort Thomas, Kentucky 41075, USA, Jeremiah.Schumm@va.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 933 EP - 942 VL - 72 IS - 6 SN - 1937-1888, 1937-1888 KW - Risk Abstracts KW - Alcohol KW - Drug abuse KW - Females KW - Psychology KW - Risk factors KW - Violence KW - aggressive behavior KW - domestic violence KW - substance use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912922408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Test+of+a+Conceptual+Model+of+Partner+Aggression+Among+Women+Entering+Substance+Use+Disorder+Treatment&rft.au=Schumm%2C+JA%3BO%27Farrell%2C+T+J%3BMurphy%2C+C+M%3BMurphy%2C+M%3BMuchowski%2C+P&rft.aulast=Schumm&rft.aufirst=JA&rft.date=2011-11-01&rft.volume=72&rft.issue=6&rft.spage=933&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Alcohol; Psychology; Risk factors; substance use; domestic violence; Females; aggressive behavior; Drug abuse; Violence ER - TY - JOUR T1 - Radioactive Material Shipping for Academic and Medical Facilities AN - 907194604; 16044282 AB - This paper is intended as an aid for preparing radioactive material shipments in academic and medical facilities. These facilities may only ship radioactive materials infrequently. As such, ensuring compliance with applicable regulations can be very time consuming. Excepted package shipments (including empty packages) and shipments using Type A packages for a select list of isotopes commonly used by academic and medical facilities are covered. Tables and flowcharts are used to direct one through the process of determining if the material to be shipped meets the definition of radioactive material for transportation purposes and if it qualifies for excepted package or Type A package shipment. The reader is then directed to procedures to properly prepare, document, and ship the radioactive material package. JF - Health Physics AU - Vernig, P G AU - Tipping, T N AU - Herrold, J AU - Ward, P AD - VA Eastern Colorado Health Care System, 1055 Clermont Street, Denver, CO 80220, USA, peter.vernig@va.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 154 EP - 159 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 101 IS - 5 SN - 0017-9078, 0017-9078 KW - Pollution Abstracts KW - Ships KW - Isotopes KW - Transportation KW - Radioactive materials KW - Compliance KW - Packaging KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907194604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Radioactive+Material+Shipping+for+Academic+and+Medical+Facilities&rft.au=Vernig%2C+P+G%3BTipping%2C+T+N%3BHerrold%2C+J%3BWard%2C+P&rft.aulast=Vernig&rft.aufirst=P&rft.date=2011-11-01&rft.volume=101&rft.issue=5&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Ships; Isotopes; Transportation; Compliance; Radioactive materials; Packaging ER - TY - JOUR T1 - Novel mineral contrast agent for magnetic resonance studies of bone implants grown on a chick chorioallantoic membrane super(a~) super(a)&am p; #152; a~ AN - 904494277; 15937922 AB - Magnetic resonance imaging (MRI) studies of tissue engineered constructs prior to implantation clearly demonstrate the utility of the MRI technique for studying the bone formation process. To test the utility of our MRI protocols for explant studies, we present a novel test platform in which osteoblast-seeded scaffolds were implanted on the chorioallantoic membrane of a chick embryo. Scaffolds from the following experimental groups were examined by high-resolution MRI: (a) cell-seeded implanted scaffolds (CIM), (b) unseeded implanted scaffolds (UCIM), (c) cell-seeded scaffolds in static culture (CIV) and (d) unseeded scaffolds in static culture (UCIV). The reduction in water proton transverse relaxation times and the concomitant increase in water proton magnetization transfer ratios for CIM and CIV scaffolds, compared to UCIV scaffolds, were consistent with the formation of a bone-like tissue within the polymer scaffold, which was confirmed by immunohistochemistry and fluorescence microscopy. However, the presence of angiogenic vessels and fibrotic adhesions around UCIM scaffolds can confound MRI findings of bone deposition. Consequently, to improve the specificity of the MRI technique for detecting mineralized deposits within explanted tissue engineered bone constructs, we introduce a novel contrast agent that uses alendronate to target a Food and Drug Administration-approved MRI contrast agent (Gd-DOTA) to bone mineral. Our contrast agent termed GdALN was used to uniquely identify mineralized deposits in representative samples from our four experimental groups. After GdALN treatment, both CIM and CIV scaffolds, containing mineralized deposits, showed marked signal enhancement on longitudinal relaxation time-weighted (T1W) images compared to UCIV scaffolds. Relative to UCIV scaffolds, some enhancement was observed in T1W images of GdALN-treated UCIM scaffolds, subjacent to the dark adhesions at the scaffold surface, possibly from dystrophic mineral formed in the fibrotic adhesions. Notably, residual dark areas on T1W images of CIM and UCIM scaffolds were attributable to blood inside infiltrating vessels. In summary, we present the efficacy of GdALN for sensitizing the MRI technique to the deposition of mineralized deposits in explanted polymeric scaffolds. JF - Magnetic Resonance Imaging AU - Chesnick, Ingrid E AU - Fowler, Carol B AU - Mason, Jeffrey T AU - Potter, Kimberlee AD - Department of Biophysics, Armed Forces Institute of Pathology Annex, Rockville, MD 20850, USA, kimberlee.potter@va.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1244 EP - 1254 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 29 IS - 9 SN - 0730-725X, 0730-725X KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Deposits KW - Bisphosphonates KW - Protons KW - Food KW - Magnetic resonance imaging KW - Angiogenesis KW - Cell culture KW - scaffolds KW - Blood KW - Chorioallantoic membrane KW - Contrast media KW - Alendronic acid KW - N.M.R. KW - Bone implants KW - Drugs KW - Minerals KW - Immunohistochemistry KW - Explants KW - Osteogenesis KW - W 30910:Imaging KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904494277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Novel+mineral+contrast+agent+for+magnetic+resonance+studies+of+bone+implants+grown+on+a+chick+chorioallantoic+membrane+super%28a%7E%29+super%28a%29%26amp%3Bam+p%3B+%23152%3B+a%7E&rft.au=Chesnick%2C+Ingrid+E%3BFowler%2C+Carol+B%3BMason%2C+Jeffrey+T%3BPotter%2C+Kimberlee&rft.aulast=Chesnick&rft.aufirst=Ingrid&rft.date=2011-11-01&rft.volume=29&rft.issue=9&rft.spage=1244&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2011.07.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Deposits; Bisphosphonates; Protons; Food; Magnetic resonance imaging; Angiogenesis; Cell culture; scaffolds; Blood; Chorioallantoic membrane; Contrast media; N.M.R.; Alendronic acid; Bone implants; Explants; Immunohistochemistry; Minerals; Drugs; Osteogenesis DO - http://dx.doi.org/10.1016/j.mri.2011.07.022 ER - TY - JOUR T1 - HIV-HBV vaccine escape mutant infection with loss of HBV surface antibody and persistent HBV viremia on tenofovir/emtricitabine without antiviral resistance AN - 902369346; 15892658 AB - We report a case of acute hepatitis B virus genotype A vaccine escape mutant infection with loss of HBV vaccine-induced seropositivity in a HIV-1 infected patient. His HBV is unresponsive to tenofovir/emtricitabine treatment demonstrated by persistent viremia despite lacking known resistance mutations and while having an undetectable HIV-1 viral load. JF - Journal of Clinical Virology AU - Schirmer, P AU - Winters, M AU - Holodniy, M AD - Department of Veterans Affairs, Office of Public Health, Palo Alto, CA, USA, patricia.schirmer@va.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 261 EP - 264 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 52 IS - 3 SN - 1386-6532, 1386-6532 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Hepatitis B virus KW - tenofovir KW - Genotypes KW - Infection KW - Hepatitis KW - Antibodies KW - Emtricitabine KW - Case reports KW - Human immunodeficiency virus 1 KW - Vaccines KW - Viremia KW - Mutation KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902369346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Virology&rft.atitle=HIV-HBV+vaccine+escape+mutant+infection+with+loss+of+HBV+surface+antibody+and+persistent+HBV+viremia+on+tenofovir%2Femtricitabine+without+antiviral+resistance&rft.au=Schirmer%2C+P%3BWinters%2C+M%3BHolodniy%2C+M&rft.aulast=Schirmer&rft.aufirst=P&rft.date=2011-11-01&rft.volume=52&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Virology&rft.issn=13866532&rft_id=info:doi/10.1016%2Fj.jcv.2011.07.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Hepatitis; Antibodies; Case reports; Emtricitabine; tenofovir; Genotypes; Viremia; Vaccines; Infection; Mutation; Hepatitis B virus; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.jcv.2011.07.014 ER - TY - JOUR T1 - Poor response to sertraline in methamphetamine dependence is associated with sustained craving for methamphetamine AN - 1761652793; 201200983 AB - Background: Depression is common among individuals with methamphetamine (MA) use disorders. As agents that enhance serotonergic function are frequently used to treat depression, one might predict that they would be useful medications for MA dependence. However, clinical trials of serotonergic agents for MA addiction have been unsuccessful. Objective: To identify factors that distinguish MA-dependent research participants who increased MA self-administration while receiving treatment with the selective serotonin reuptake inhibitor (SSRI) sertraline from other groups of participants. Method: Using a dataset from a 12-week randomized, placebo-controlled trial of sertraline (100 mg daily) for MA addiction, we identified participants who had completed at least 8 weeks of the trial (n = 61 sertraline, n = 68 placebo). We compared the proportions of MA-positive urine tests for weeks 8-12 of the trial for these subjects to their pre-randomization baseline, and identified those subjects who increased MA use during treatment. Using classification trees, we then assessed all data collected during the study to identify factors associated with increasing MA use during treatment with sertraline, compared to placebo. Results: More subjects in the sertraline condition increased MA use during treatment (n = 13) than in the placebo condition (n = 5; p = 0.03). Classification trees identified multiple factors from both pre-treatment and in-treatment data that were associated with increased MA use during treatment. Only elevated in-treatment craving for MA specifically characterized subjects in the sertraline group who increased their MA use. Conclusions: Some MA-abusing individuals treated with SSRIs have sustained craving with an increased propensity to relapse during treatment despite psychosocial treatment interventions. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Zorick, Todd AU - Sugar, Catherine A AU - Hellemann, Gerhard AU - Shoptaw, Steve AU - London, Edythe D AD - Department of Psychiatry, Greater Los Angeles Veterans Administration Healthcare System, Los Angeles, CA 90073, USA todd.zorick@va.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 500 EP - 503 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 118 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Antidepressants Sertraline Methamphetamine Addiction Craving Classification and regression trees KW - Craving KW - Methamphetamine KW - Classification KW - Sertraline KW - Addiction KW - Serotonin reuptake inhibitors KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761652793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Poor+response+to+sertraline+in+methamphetamine+dependence+is+associated+with+sustained+craving+for+methamphetamine&rft.au=Zorick%2C+Todd%3BSugar%2C+Catherine+A%3BHellemann%2C+Gerhard%3BShoptaw%2C+Steve%3BLondon%2C+Edythe+D&rft.aulast=Zorick&rft.aufirst=Todd&rft.date=2011-11-01&rft.volume=118&rft.issue=2-3&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2011.04.015 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Sertraline; Craving; Methamphetamine; Serotonin reuptake inhibitors; Classification; Addiction DO - http://dx.doi.org/10.1016/j.drugalcdep.2011.04.015 ER - TY - JOUR T1 - Longitudinal Change in Cognitive Function and Medication Adherence in HIV-Infected Adults AN - 1081869504; 201206414 AB - Neuropsychological (NP) dysfunction has been linked to poor medication adherence among HIV-infected adults. However, there is a dearth of research examining longitudinal changes in the relationship between NP status and adherence rates. We hypothesized that declines in NP functioning would be associated with a corresponding decline in medication adherence while stable NP functioning would be associated with stable or improving adherence rates. Participants included 215 HIV-infected adults who underwent cognitive testing at study entry and six months later. Compared to the NP stable group, the NP decline group showed a greater drop in adherence rates. Further analysis revealed that, beyond global NP, learning and memory was significantly associated with changes in adherence rates. These findings further support the link between cognitive functioning and medication adherence and illustrates the importance of documenting changes in cognitive abilities for identifying individuals at risk for poor adherence. Adapted from the source document. JF - AIDS and Behavior AU - Becker, Brian W AU - Thames, April D AU - Woo, Ellen AU - Castellon, Steven A AU - Hinkin, Charles H AD - Neuropsychology Lab (256), VA Greater Los Angeles Health Care System, 11301 Wilshire, Boulevard, Los Angeles, CA, 90073, USA brian.becker@va.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1888 EP - 1894 PB - Springer, Dordrecht, The Netherlands VL - 15 IS - 8 SN - 1090-7165, 1090-7165 KW - Risk KW - Memory KW - Cognitive Functioning KW - Cognition KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081869504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Longitudinal+Change+in+Cognitive+Function+and+Medication+Adherence+in+HIV-Infected+Adults&rft.au=Becker%2C+Brian+W%3BThames%2C+April+D%3BWoo%2C+Ellen%3BCastellon%2C+Steven+A%3BHinkin%2C+Charles+H&rft.aulast=Becker&rft.aufirst=Brian&rft.date=2011-11-01&rft.volume=15&rft.issue=8&rft.spage=1888&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-011-9924-z LA - English DB - Social Services Abstracts N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Cognition; Cognitive Functioning; Risk; Memory DO - http://dx.doi.org/10.1007/s10461-011-9924-z ER - TY - JOUR T1 - Effect of Gravity on Robot-Assisted Motor Training After Chronic Stroke: A Randomized Trial AN - 1034829781; 15957195 AB - Conroy SS, Whitall J, Dipietro L, Jones-Lush LM, Zhan M, Finley MA, Wittenberg GF, Krebs HI, Bever CT. Effect of gravity on robot-assisted motor training after chronic stroke: a randomized trial. Objectives: To determine the efficacy of 2 distinct 6-week robot-assisted reaching programs compared with an intensive conventional arm exercise program (ICAE) for chronic, stroke-related upper-extremity (UE) impairment. To examine whether the addition of robot-assisted training out of the horizontal plane leads to improved outcomes. Design: Randomized controlled trial, single-blinded, with 12-week follow-up. Setting: Research setting in a large medical center. Participants: Adults (N=62) with chronic, stroke-related arm weakness stratified by impairment severity using baseline UE motor assessments. Interventions: Sixty minutes, 3 times a week for 6 weeks of robot-assisted planar reaching (gravity compensated), combined planar with vertical robot-assisted reaching, or intensive conventional arm exercise program. Main Outcome Measure: UE Fugl-Meyer Assessment (FMA) mean change from baseline to final training. Results: All groups showed modest gains in the FMA from baseline to final with no significant between group differences. Most change occurred in the planar robot group (mean change +/- SD, 2.94+/-0.77; 95% confidence interval [CI], 1.40-4.47). Participants with greater motor impairment (n=41) demonstrated a larger difference in response (mean change +/- SD, 2.29+/-0.72; 95% CI, 0.85-3.72) for planar robot-assisted exercise compared with the intensive conventional arm exercise program (mean change +/- SD, 0.43+/-0.72; 95% CI, -1.00 to 1.86). Conclusions: Chronic UE deficits because of stroke are responsive to intensive motor task training. However, training outside the horizontal plane in a gravity present environment using a combination of vertical with planar robots was not superior to training with the planar robot alone. JF - Archives of Physical Medicine and Rehabilitation AU - Conroy, Susan S AU - Whitall, Jill AU - Dipietro, Laura AU - Jones-Lush, Lauren M AU - Zhan, Min AU - Finley, Margaret A AU - Wittenberg, George F AU - Krebs, Hermano I AU - Bever, Christopher T AD - Veterans Affairs Maryland Health Care System, Research Service, University of Maryland School of Medicine, Baltimore, MD, susan.conroy@va.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1754 EP - 1761 PB - Elsevier B.V., The Curtis Center, Independence Square West Philadelphia PA 19106-3399 United States VL - 92 IS - 11 SN - 0003-9993, 0003-9993 KW - Physical Education Index KW - Adults KW - Archives KW - Evaluation KW - Exercise (programs) KW - Gravity KW - Research (statistical design) KW - Self efficacy KW - Stroke KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034829781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Effect+of+Gravity+on+Robot-Assisted+Motor+Training+After+Chronic+Stroke%3A+A+Randomized+Trial&rft.au=Conroy%2C+Susan+S%3BWhitall%2C+Jill%3BDipietro%2C+Laura%3BJones-Lush%2C+Lauren+M%3BZhan%2C+Min%3BFinley%2C+Margaret+A%3BWittenberg%2C+George+F%3BKrebs%2C+Hermano+I%3BBever%2C+Christopher+T&rft.aulast=Conroy&rft.aufirst=Susan&rft.date=2011-11-01&rft.volume=92&rft.issue=11&rft.spage=1754&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/10.1016%2Fj.apmr.2011.06.016 LA - English DB - Physical Education Index N1 - Date revised - 2012-08-01 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Evaluation; Research (statistical design); Gravity; Stroke; Adults; Archives; Exercise (programs); Self efficacy DO - http://dx.doi.org/10.1016/j.apmr.2011.06.016 ER - TY - JOUR T1 - Deployment-related TBI, persistent postconcussive symptoms, PTSD, and depression in OEF/OIF veterans AN - 1023096143; 201216869 AB - Objective: A substantial proportion of the more than 2 million service members who have served in Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) have experienced a traumatic brain injury (TBI). Understanding the long-term impact of TBI is complicated by the nonspecific nature of postconcussive symptoms (PCSs) and the high rates of co-occurrence among TBI, posttraumatic stress disorder (PTSD), and depression. The goal of the present research was to examine the relations among TBI, persistent PCSs, and symptoms of PTSD and depression among returning OEF/OIF veterans. Method: 213 OEF/OIF veterans (87% male) completed a semistructured screening interview assessing deployment-related TBI and current, persistent PCSs. Participants also completed self-report measures of combat exposure and current symptoms of PTSD and depression. Results: Nearly half (46%) of sampled veterans screened positive for TBI, the majority of whom (85%) reported at least one persistent PCS after removing PCSs that overlapped with PTSD and depression. Veterans with deployment-related TBI reported higher levels of combat exposure and symptoms of PTSD and depression. Structural equation modeling was used to assess the fit of 3 models of the relationships among TBI, combat exposure, persistent PCSs, PTSD, and depression. Consistent with hypotheses, the best-fitting model was one in which the effects of TBI on both PTSD and depression were fully mediated by nonoverlapping persistent PCSs. Conclusions: These findings highlight the importance of addressing persistent PCSs in order to facilitate the functional recovery of returning war veterans. [Copyright The American Psychological Association.] JF - Rehabilitation Psychology AU - Morissette, Sandra B AU - Woodward, Matthew AU - Kimbrel, Nathan A AU - Meyer, Eric C AU - Kruse, Marc I AU - Dolan, Sara AU - Gulliver, Suzy Bird Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 340 EP - 350 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 56 IS - 4 SN - 0090-5550, 0090-5550 KW - PTSD KW - TBI KW - postconcussive symptoms KW - veterans KW - Operation Enduring Freedom KW - Operation Iraqi Freedom KW - depression KW - Veterans KW - Symptoms KW - Depression KW - Posttraumatic stress disorder KW - Freedom KW - Selfreport KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023096143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rehabilitation+Psychology&rft.atitle=Deployment-related+TBI%2C+persistent+postconcussive+symptoms%2C+PTSD%2C+and+depression+in+OEF%2FOIF+veterans&rft.au=Morissette%2C+Sandra+B%3BWoodward%2C+Matthew%3BKimbrel%2C+Nathan+A%3BMeyer%2C+Eric+C%3BKruse%2C+Marc+I%3BDolan%2C+Sara%3BGulliver%2C+Suzy+Bird&rft.aulast=Morissette&rft.aufirst=Sandra&rft.date=2011-11-01&rft.volume=56&rft.issue=4&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=Rehabilitation+Psychology&rft.issn=00905550&rft_id=info:doi/10.1037%2Fa0025462 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Depression; Veterans; Symptoms; Freedom; Selfreport DO - http://dx.doi.org/10.1037/a0025462 ER - TY - JOUR T1 - Factor structure of posttraumatic stress disorder symptoms in OEF/OIF veterans presenting to a polytrauma clinic AN - 1023091983; 201216374 AB - Objective: A significant number of Operation Iraqi Freedom/Operation Enduring Freedom (OEF/OIF) veterans are returning from deployment and presenting to Veterans Health Administration (VHA) polytrauma clinics with elevated rates of posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI). Inherent to the accurate assessment and treatment of this diagnostically complex group of veterans is the assumption that the construct of PTSD is the same in this population as in other trauma groups. To our knowledge, no previous study has examined the structure of PTSD in this relevant and fast-growing population of treatment-seeking OEF/OIF veterans. Evidence suggests that the latent structure of PTSD symptoms is best represented by a four-factor model, rather than the three-factor model found in the current DSM-IV-TR. Thus, we examined the three and four-factor models using the PTSD Check List-Civilian (PCL-C) in a sample of treatment-seeking OEF/OIF veterans seen through a VHA polytrauma clinic. Method: A chart review was conducted for OEF/OIF veterans (N = 361) seen through a VHA outpatient polytrauma clinic from September 2007 through August 2008. Participants completed the PCL-C as part of a comprehensive polytrauma evaluation. Results: Confirmatory factor analyses showed that the DSM-IV-TR three-factor model did not fit the data well. A direct comparison showed that the four-factor model provided a superior fit relative to the three-factor model. Conclusion: Results extend the generalizability of the four-factor model to OEF/OIF veterans presenting to Veterans Health Administration (VHA) polytrauma clinics. [Copyright The American Psychological Association.] JF - Rehabilitation Psychology AU - Maestas, Kacey Little AU - Benge, Jared F AU - Pastorek, Nicholas J AU - LeMaire, Ashley AU - Darrow, Rachel Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 366 EP - 373 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 56 IS - 4 SN - 0090-5550, 0090-5550 KW - factor analysis KW - mild traumatic brain injury KW - posttraumatic stress KW - veterans KW - factor structure KW - polytrauma KW - Operation Iraqi Freedom/Operation Enduring Freedom KW - treatment-seeking KW - Veterans KW - Posttraumatic stress disorder KW - Freedom KW - Clinics KW - Military hospitals KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023091983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rehabilitation+Psychology&rft.atitle=Factor+structure+of+posttraumatic+stress+disorder+symptoms+in+OEF%2FOIF+veterans+presenting+to+a+polytrauma+clinic&rft.au=Maestas%2C+Kacey+Little%3BBenge%2C+Jared+F%3BPastorek%2C+Nicholas+J%3BLeMaire%2C+Ashley%3BDarrow%2C+Rachel&rft.aulast=Maestas&rft.aufirst=Kacey&rft.date=2011-11-01&rft.volume=56&rft.issue=4&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=Rehabilitation+Psychology&rft.issn=00905550&rft_id=info:doi/10.1037%2Fa0025447 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Veterans; Posttraumatic stress disorder; Clinics; Helpseeking; Military hospitals; Freedom DO - http://dx.doi.org/10.1037/a0025447 ER - TY - JOUR T1 - Implications of Treatment on Body Image and Quality of Life AN - 1023091454; 201214957 AB - Objectives: To describe the changes in body image secondary to the treatment of prostate cancer, and to provide a review of the literature regarding body image assessment and its relationship to quality of life (QOL) among men with prostate cancer. Data Sources: Review of current and classic literature. Conclusion: There is strong evidence for the existence of a relationship between body image perception and QOL in men with prostate cancer. Implications for Nursing Practice: Understanding the effect of body image changes on QOL will allow us to develop targeted interventions designed to improve the QOL of survivors of prostate cancer. [Copyright Elsevier B.V.] JF - Seminars in Oncology Nursing AU - Harrington, Joanne M Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 290 EP - 299 PB - Elsevier Ltd, The Netherlands VL - 27 IS - 4 SN - 0749-2081, 0749-2081 KW - Prostate cancer KW - body image KW - quality of life KW - Men KW - Nursing KW - Survivors KW - Prostatic cancer KW - Body image KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023091454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Oncology+Nursing&rft.atitle=Implications+of+Treatment+on+Body+Image+and+Quality+of+Life&rft.au=Harrington%2C+Joanne+M&rft.aulast=Harrington&rft.aufirst=Joanne&rft.date=2011-11-01&rft.volume=27&rft.issue=4&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Oncology+Nursing&rft.issn=07492081&rft_id=info:doi/10.1016%2Fj.soncn.2011.07.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Quality of life; Body image; Prostatic cancer; Men; Nursing; Survivors DO - http://dx.doi.org/10.1016/j.soncn.2011.07.007 ER - TY - JOUR T1 - The Department of Veterans Affairs Nursing Academy (VANA): Forging strategic alliances with schools of nursing to address nursing's workforce needs AN - 1023091116; 201213023 AB - In 2007, the Department of Veterans Affairs (VA) established the VA Nursing Academy (VANA), a 5-year, $60-million pilot program funding 15 partnerships between schools of nursing and local VA health care facilities nationwide, to expand nursing faculty, enhance clinical faculty development, increase nursing student enrollment, and promote educational innovations. VA is an ideal setting for educating nursing students owing to a well-educated registered nurse staff, an array of traditional and nontraditional settings, a state-of-the-art computerized electronic health record system, and a unique patient population. Challenges related to the complex nature of VANA partnerships, conceptualized as strategic alliances created between disparate subunits, each embedded in a larger organization, require careful governance to ensure smooth implementation. To ensure the program's aims are met, a 6-year national evaluation has been funded to help identify which strategies best achieve VANA's goals. The speed of economic recovery and the resulting changes in the nursing workforce are important determinants of VANA's future. [Copyright Elsevier B.V.] JF - Nursing Outlook AU - Bowman, Candice C AU - Johnson, Linda AU - Cox, Malcolm AU - Rick, Catherine AU - Dougherty, Mary AU - Alt-White, Anna C AU - Wyte, Tamar AU - Needleman, Jack AU - Dobalian, Aram AD - HSR&D Center for the Study of Healthcare Provider Behavior, VA Greater Los Angeles Healthcare System candice.bowman@va.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 299 EP - 307 PB - Elsevier Ltd, The Netherlands VL - 59 IS - 6 SN - 0029-6554, 0029-6554 KW - Partnerships KW - Clinical instruction KW - Veterans Affairs KW - Veterans KW - Clinical nursing KW - Nursing KW - Labour force KW - Universities KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023091116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Outlook&rft.atitle=The+Department+of+Veterans+Affairs+Nursing+Academy+%28VANA%29%3A+Forging+strategic+alliances+with+schools+of+nursing+to+address+nursing%27s+workforce+needs&rft.au=Bowman%2C+Candice+C%3BJohnson%2C+Linda%3BCox%2C+Malcolm%3BRick%2C+Catherine%3BDougherty%2C+Mary%3BAlt-White%2C+Anna+C%3BWyte%2C+Tamar%3BNeedleman%2C+Jack%3BDobalian%2C+Aram&rft.aulast=Bowman&rft.aufirst=Candice&rft.date=2011-11-01&rft.volume=59&rft.issue=6&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Nursing+Outlook&rft.issn=00296554&rft_id=info:doi/10.1016%2Fj.outlook.2011.04.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nursing; Clinical nursing; Partnerships; Veterans; Universities; Labour force DO - http://dx.doi.org/10.1016/j.outlook.2011.04.006 ER - TY - CPAPER T1 - Staff Well-Being and Retention: Management Perspectives and Blueprints for Change in County Mental Health Systems T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313016948; 6050791 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Magnabosco, Jennifer AU - Southard, Marvin Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - mental disorders KW - Mental disorders KW - Engineering drawings UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313016948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Staff+Well-Being+and+Retention%3A+Management+Perspectives+and+Blueprints+for+Change+in+County+Mental+Health+Systems&rft.au=Magnabosco%2C+Jennifer%3BSouthard%2C+Marvin&rft.aulast=Magnabosco&rft.aufirst=Jennifer&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Implementation of Nurse-Initiated HIV Rapid Testing in VA Substance Use Disorder Clinics T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312995341; 6051766 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Conners, Erin AU - Butler, Jaimi AU - Hagedorn, Hildi AU - Wilson, Patricia AU - Felmet, Kandi AU - Bonanomi, Helen AU - Haas, Gretchen AU - Klima, Gloria AU - Sudzina, Eileen AU - Anaya, Henry Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Human immunodeficiency virus KW - substance use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Implementation+of+Nurse-Initiated+HIV+Rapid+Testing+in+VA+Substance+Use+Disorder+Clinics&rft.au=Conners%2C+Erin%3BButler%2C+Jaimi%3BHagedorn%2C+Hildi%3BWilson%2C+Patricia%3BFelmet%2C+Kandi%3BBonanomi%2C+Helen%3BHaas%2C+Gretchen%3BKlima%2C+Gloria%3BSudzina%2C+Eileen%3BAnaya%2C+Henry&rft.aulast=Conners&rft.aufirst=Erin&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Differences between Veteran suicides with and without psychiatric symptoms T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312984842; 6051579 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Britton, Peter AU - Ilgen, Mark AU - Valenstein, Marcia AU - Knox, Kerry AU - Claassen, Cynthia AU - Conner, Kenneth Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - suicide KW - Suicide KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312984842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Differences+between+Veteran+suicides+with+and+without+psychiatric+symptoms&rft.au=Britton%2C+Peter%3BIlgen%2C+Mark%3BValenstein%2C+Marcia%3BKnox%2C+Kerry%3BClaassen%2C+Cynthia%3BConner%2C+Kenneth&rft.aulast=Britton&rft.aufirst=Peter&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - VA HealthCare: A High-Qualtiy, Cost-Effective, Resource for 21st Century Medical Education for All Part II T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312984236; 6051570 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Kasprzyk, Daniel Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Economics KW - Education KW - Health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312984236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=VA+HealthCare%3A+A+High-Qualtiy%2C+Cost-Effective%2C+Resource+for+21st+Century+Medical+Education+for+All+Part+II&rft.au=Kasprzyk%2C+Daniel&rft.aulast=Kasprzyk&rft.aufirst=Daniel&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - VA Healthcare: A High-Quality, Cost-Effective, Resource for 21st Century Medical Education for All Part I T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312984194; 6051569 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Shocket, Everett Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Economics KW - Education KW - Health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312984194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=VA+Healthcare%3A+A+High-Quality%2C+Cost-Effective%2C+Resource+for+21st+Century+Medical+Education+for+All+Part+I&rft.au=Shocket%2C+Everett&rft.aulast=Shocket&rft.aufirst=Everett&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Veteran Homelessness 2000-2010: Examining a Comprehensive Model of Outcome Predictors T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312983671; 6051310 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Casey, Roger AU - Schinka, John AU - Kasprow, Wes Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Homelessness KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312983671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Veteran+Homelessness+2000-2010%3A+Examining+a+Comprehensive+Model+of+Outcome+Predictors&rft.au=Casey%2C+Roger%3BSchinka%2C+John%3BKasprow%2C+Wes&rft.aulast=Casey&rft.aufirst=Roger&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Benefits of certification in public health for the individual and the profession T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312974562; 6050322 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Luscri, Lorry Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - certification KW - Certification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312974562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Benefits+of+certification+in+public+health+for+the+individual+and+the+profession&rft.au=Luscri%2C+Lorry&rft.aulast=Luscri&rft.aufirst=Lorry&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Association of race, cultural factors, and health related quality of life T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312943292; 6050664 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Myaskovsky, Larissa AU - Burkitt, Kelly AU - Fyffe, Denise AU - Lichy, Alison AU - Ljungberg, Inger AU - Kloke, John AU - Switzer, Galen AU - Fine, Michael AU - Boninger, Michael Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - quality of life KW - culture KW - Races KW - Quality of life KW - Subpopulations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312943292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Association+of+race%2C+cultural+factors%2C+and+health+related+quality+of+life&rft.au=Myaskovsky%2C+Larissa%3BBurkitt%2C+Kelly%3BFyffe%2C+Denise%3BLichy%2C+Alison%3BLjungberg%2C+Inger%3BKloke%2C+John%3BSwitzer%2C+Galen%3BFine%2C+Michael%3BBoninger%2C+Michael&rft.aulast=Myaskovsky&rft.aufirst=Larissa&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Implementing the Patient Center Medical Home in Veterans Health Administration Primary Care T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312926838; 6050493 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Kirsh, Susan AU - Hein, Michael AU - Shear, Joanne AU - Stark, Richard AU - Schectman, Gordon Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312926838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Implementing+the+Patient+Center+Medical+Home+in+Veterans+Health+Administration+Primary+Care&rft.au=Kirsh%2C+Susan%3BHein%2C+Michael%3BShear%2C+Joanne%3BStark%2C+Richard%3BSchectman%2C+Gordon&rft.aulast=Kirsh&rft.aufirst=Susan&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Suicidal Behaviors in Homeless Older Veterans T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312905540; 6051307 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Casey, Roger AU - Schinka, John AU - Bossarte, Robert AU - Kasprow, Wes Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - suicide KW - homelessness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312905540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Suicidal+Behaviors+in+Homeless+Older+Veterans&rft.au=Casey%2C+Roger%3BSchinka%2C+John%3BBossarte%2C+Robert%3BKasprow%2C+Wes&rft.aulast=Casey&rft.aufirst=Roger&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice AN - 902383756; 15763279 AB - Caffeine intake has been associated with a lower incidence of Alzheimer's disease (AD) in humans. In AD mouse models, caffeine significantly decreases senile plaques and amyloid beta (A beta ) levels while also protecting against or reversing cognitive impairment. To understand the mechanism(s) underlying the protective effects of caffeine against AD pathology, we investigated the effects of a two-week treatment with caffeine (3mg/day) in transgenic (APPswe) mice and non-transgenic (NT) mice on signaling factors involved in neuronal plasticity and survival. We evaluated cAMP-dependent protein kinase A (PKA), phospho-cyclic AMP response-element binding protein (phospho-CREB), and the pro-apoptotic protein kinases extracellular signal-regulated kinase 1/2 (phospho-ERK) and phospho-c-Jun N-terminal kinase 1 (phospho-JNK) in the striatum and frontal cortex of caffeine-treated mice. In the striatum, APPswe control mice exhibited a significant decrease in phospho-CREB, as well as significant increases in phospho-JNK and phospho-ERK in comparison to NT mice. Caffeine treatment stimulated PKA activity, increased phospho-CREB levels, and decreased phospho-JNK and phospho-ERK expression in the striatum of APPswe mice, all of which are thought to be beneficial changes for brain function. Even caffeine-treated NT mice exhibited some of these changes in striatum. In the frontal cortex, caffeine did not significantly increase phospho-CREB and PKA activity, but significantly reduced phospho-JNK and phospho-ERK expression in both APPswe and NT mice. These results suggest that caffeine shifts the balance between neurodegeneration and neuronal survival toward the stimulation of pro-survival cascades and inhibition of pro-apoptotic pathways in the striatum and/or cortex, which may contribute to its beneficial effects against AD. JF - Brain Research AU - Zeitlin, Ross AU - Patel, Sagar AU - Burgess, Sarah AU - Arendash, Gary W AU - Echeverria, Valentina Y1 - 2011/10/12/ PY - 2011 DA - 2011 Oct 12 SP - 127 EP - 136 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1417 SN - 0006-8993, 0006-8993 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Cell survival KW - Protein kinase A KW - c-Jun amino-terminal kinase KW - Plasticity (neural) KW - Alzheimer's disease KW - Animal models KW - Brain KW - Cortex (frontal) KW - AMP KW - Transgenic mice KW - Extracellular signal-regulated kinase KW - Neurodegenerative diseases KW - Cognitive ability KW - Neostriatum KW - Caffeine KW - beta -Amyloid KW - Signal transduction KW - Senile plaques KW - W 30925:Genetic Engineering KW - N3 11001:Behavioral and Cognitive Neuroscience KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902383756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Caffeine+induces+beneficial+changes+in+PKA+signaling+and+JNK+and+ERK+activities+in+the+striatum+and+cortex+of+Alzheimer%27s+transgenic+mice&rft.au=Zeitlin%2C+Ross%3BPatel%2C+Sagar%3BBurgess%2C+Sarah%3BArendash%2C+Gary+W%3BEcheverria%2C+Valentina&rft.aulast=Zeitlin&rft.aufirst=Ross&rft.date=2011-10-12&rft.volume=1417&rft.issue=&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/10.1016%2Fj.brainres.2011.08.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Cell survival; Protein kinase A; c-Jun amino-terminal kinase; Alzheimer's disease; Plasticity (neural); Brain; Animal models; Cortex (frontal); AMP; Transgenic mice; Neurodegenerative diseases; Extracellular signal-regulated kinase; Cognitive ability; Neostriatum; Caffeine; beta -Amyloid; Senile plaques; Signal transduction DO - http://dx.doi.org/10.1016/j.brainres.2011.08.036 ER - TY - JOUR T1 - Maladaptive Attributions and Dyadic Behavior are Associated in Engaged Couples AN - 925741081; 201205207 AB - The present study further developed the cognitive-behavioral model of marriage by reviewing the literature on the attribution-behavior association in married samples and testing the association in an engaged sample. Forty-three couples completed measures of maladaptive attributions and participated in two problem-solving conversations that were behaviorally coded. TO the extent that men made maladaptive attributions about hypothetical situations, men and women displayed fewer positive behaviors and more negative behaviors during problem-solving interactions. Women's and men's maladaptive attributions about actual problems in their relationship were associated to their own behavior (fewer positive and more negative behaviors) during the couples' discussions of those problems. These findings were present when controlling for depressive symptoms and maintained when controlling for relationship satisfaction. The implications of these findings for the development and prevention of marital discord are discussed. Adapted from the source document. JF - Journal of Social and Clinical Psychology AU - Osterhout, Rebecca E AU - Frame, Laura E AU - Johnson, Matthew D AD - New Mexico Veterans Affairs Health Care System, Albuquerque, NM rebecca.osterhout@va.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 787 EP - 818 PB - Guilford Press, New York NY VL - 30 IS - 8 SN - 0736-7236, 0736-7236 KW - Cognitive behaviour therapy KW - Engaged couples KW - Attributions KW - Women KW - Marriage KW - Negative behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925741081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+and+Clinical+Psychology&rft.atitle=Maladaptive+Attributions+and+Dyadic+Behavior+are+Associated+in+Engaged+Couples&rft.au=Osterhout%2C+Rebecca+E%3BFrame%2C+Laura+E%3BJohnson%2C+Matthew+D&rft.aulast=Osterhout&rft.aufirst=Rebecca&rft.date=2011-10-01&rft.volume=30&rft.issue=8&rft.spage=787&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+and+Clinical+Psychology&rft.issn=07367236&rft_id=info:doi/10.1521%2Fjscp.2011.30.8.787 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSCPFF N1 - SubjectsTermNotLitGenreText - Attributions; Negative behaviour; Women; Engaged couples; Cognitive behaviour therapy; Marriage DO - http://dx.doi.org/10.1521/jscp.2011.30.8.787 ER - TY - JOUR T1 - Trauma Exposure and PTSD Symptoms among Homeless Mothers: Predicting Coping and Mental Health Outcomes AN - 925740522; 201205558 AB - This longitudinal study investigated associations of posttraumatic stress disorder (PTSD) symptoms from prior trauma with coping with a subsequent stressor and with psychological symptoms. Seventy homeless mothers provided information about previous trauma history and posttraumatic stress symptoms at baseline; coping and psychological symptoms were assessed 15 months later. Results revealed moderately high levels of PTSD in this sample. PTSD symptomatology was related to increased avoidant coping, which mediated the relationship between previous trauma and subsequent psychological symptom severity. implications for future research and interventions to reduce the negative impact of trauma in homeless women are discussed. Adapted from the source document. JF - Journal of Social and Clinical Psychology AU - Schuster, Jennifer AU - Park, Crystal L AU - Frisman, Linda K AD - Women's Health Sciences Division, VA Boston Healthcare System jennifer.schuster@va.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 887 EP - 904 PB - Guilford Press, New York NY VL - 30 IS - 8 SN - 0736-7236, 0736-7236 KW - Psychological trauma KW - Symptoms KW - Posttraumatic stress disorder KW - Psychological problems KW - Coping KW - Homeless mothers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925740522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+and+Clinical+Psychology&rft.atitle=Trauma+Exposure+and+PTSD+Symptoms+among+Homeless+Mothers%3A+Predicting+Coping+and+Mental+Health+Outcomes&rft.au=Schuster%2C+Jennifer%3BPark%2C+Crystal+L%3BFrisman%2C+Linda+K&rft.aulast=Schuster&rft.aufirst=Jennifer&rft.date=2011-10-01&rft.volume=30&rft.issue=8&rft.spage=887&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+and+Clinical+Psychology&rft.issn=07367236&rft_id=info:doi/10.1521%2Fjscp.2011.30.8.887 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSCPFF N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Psychological trauma; Coping; Symptoms; Psychological problems; Homeless mothers DO - http://dx.doi.org/10.1521/jscp.2011.30.8.887 ER - TY - JOUR T1 - Longitudinal Health Study of US 1991 Gulf War Veterans: Changes in Health Status at 10-Year Follow-up AN - 918049845; 16099539 AB - The authors assessed changes in the health status of US 1991 Gulf War-era veterans from a 1995 baseline survey to a 2005 follow-up survey, using repeated measurement data from 5,469 deployed Gulf War veterans and 3,353 nondeployed Gulf War-era veterans who participated in both surveys. Prevalence differences in health status between the 2 surveys were estimated for adverse health indices and chronic diseases for each veteran group. Persistence risk ratios and incidence risk ratios were calculated after adjustment for demographic and military service characteristics through Mantel-Haenszel stratified analysis. At 10-year follow-up, deployed veterans were more likely to report persistent poor health, as measured by the health indices (functional impairment, limitation of activities, repeated clinic visits, recurrent hospitalizations, perception of health as fair or poor, chronic fatigue syndrome-like illness, and posttraumatic stress disorder), than nondeployed veterans. Additionally, deployed veterans were more likely to experience new onset of adverse health (as measured by the indices) and certain chronic diseases than were nondeployed veterans. During the 10-year period from 1995 to 2005, the health of deployed veterans worsened in comparison with nondeployed veterans because of a higher rate of new onset of various health outcomes and greater persistence of previously reported adverse health on the indices. JF - American Journal of Epidemiology AU - Li, Bo AU - Mahan, Clare M AU - Kang, Han K AU - Eisen, Seth A AU - Engel, Charles C Y1 - 2011/10/01/ PY - 2011 DA - 2011 Oct 01 SP - 761 EP - 768 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 174 IS - 7 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Health & Safety Science Abstracts KW - demography KW - USA KW - Psychology KW - Perception KW - Military KW - fatigue KW - Occupational health KW - H 1000:Occupational Safety and Health KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918049845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Longitudinal+Health+Study+of+US+1991+Gulf+War+Veterans%3A+Changes+in+Health+Status+at+10-Year+Follow-up&rft.au=Li%2C+Bo%3BMahan%2C+Clare+M%3BKang%2C+Han+K%3BEisen%2C+Seth+A%3BEngel%2C+Charles+C&rft.aulast=Li&rft.aufirst=Bo&rft.date=2011-10-01&rft.volume=174&rft.issue=7&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwr154 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - demography; Perception; Psychology; Military; fatigue; Occupational health; USA DO - http://dx.doi.org/10.1093/aje/kwr154 ER - TY - JOUR T1 - Post-antifungal effects and time-kill studies of anidulafungin, caspofungin, and micafungin against Candida glabrata and Candida parapsilosis AN - 904495109; 15749721 AB - Candida glabrata (Cgl) and Candida parapsilosis (Cpa) can cause serious infections and can be resistant to some antifungal drugs. In treating infections caused by these organisms, killing rates and post-antifungal effects (PAFE) are important factors in both dose interval choice and outcome. Two strains each of Cgl and Cpa were studied. For PAFE studies, each organism was exposed to micafungin (MCF), anidulafungin (ANF), or caspofungin (CAS) for 1 h at concentrations ranging from 0.25 to 16MIC. Cell suspensions were then washed 3 times and resuspended in fresh broth. Time 0 was immediately after resuspension of the yeast. Time-kill experiments were done using similar drug concentrations. Samples were removed at each time point (0-120 h) and viable counts determined. PAFE of ANF and CAS were generally very long, were markedly longer than those of MCF, and increased with increased drug concentration. For ANF and CAS, PAFE for Cgl were greater than those for Cpa only at 0.5 to 2 MIC. Time-kill experiments showed that ANF, CAS, and MCF were fungicidal at 8 to 16 MIC up to 120 h. CAS had the greatest activity against Cgl, while ANF and MCF were more active than CAS against Cpa. Because of the prolonged PAFE of these echinocandins, especially ANF and CAS, less frequent dosing during therapy of Cpa and Cgl infections could be considered. Further studies are needed to determine the clinical efficacy of longer dosing intervals. JF - Diagnostic Microbiology and Infectious Disease AU - Smith, Raymond P AU - Baltch, Aldona AU - Bopp, Lawrence H AU - Ritz, William J AU - Michelsen, Phyllis P Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 131 EP - 138 PB - Elsevier B.V., Box 882 New York NY 10159 United States VL - 71 IS - 2 SN - 0732-8893, 0732-8893 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - PAFE KW - Echinocandin effects KW - C. glabrata KW - C. parapsilosis KW - Cell suspensions KW - micafungin KW - Candida glabrata KW - Caspofungin KW - Candida parapsilosis KW - Infection KW - echinocandins KW - Drugs KW - Minimum inhibitory concentration KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - K 03400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904495109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+Microbiology+and+Infectious+Disease&rft.atitle=Post-antifungal+effects+and+time-kill+studies+of+anidulafungin%2C+caspofungin%2C+and+micafungin+against+Candida+glabrata+and+Candida+parapsilosis&rft.au=Smith%2C+Raymond+P%3BBaltch%2C+Aldona%3BBopp%2C+Lawrence+H%3BRitz%2C+William+J%3BMichelsen%2C+Phyllis+P&rft.aulast=Smith&rft.aufirst=Raymond&rft.date=2011-10-01&rft.volume=71&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Diagnostic+Microbiology+and+Infectious+Disease&rft.issn=07328893&rft_id=info:doi/10.1016%2Fj.diagmicrobio.2011.06.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Cell suspensions; micafungin; Caspofungin; echinocandins; Infection; Minimum inhibitory concentration; Drugs; Candida glabrata; Candida parapsilosis DO - http://dx.doi.org/10.1016/j.diagmicrobio.2011.06.018 ER - TY - JOUR T1 - The comparative effectiveness of cognitive processing therapy for male veterans treated in a VHA posttraumatic stress disorder residential rehabilitation program. AN - 1023091193; 201212444 AB - Objective: To examine the effectiveness of group cognitive processing therapy (CPT) relative to trauma-focused group treatment as usual (TAU) in the context of a Veterans Health Administration (VHA) posttraumatic stress disorder (PTSD) residential rehabilitation program. Method: Participants were 2 cohorts of male patients in the same program treated with either CPT (n = 104) or TAU (n = 93; prior to the implementation of CPT). Cohorts were compared on changes from pre- to posttreatment using the PTSD Checklist (PCL; Weathers, Litz, Herman, Huska, & Keane, 1993) and other measures of symptoms and functioning. Minorities represented 41% of the sample, and the mean age was 52 years (SD = 9.22). The CPT group was significantly younger and less likely to receive disability benefits for PTSD; however, these variables were not related to outcome. Results: Analyses of covariance controlling for intake symptom levels and cohort differences revealed that CPT participants evidenced more symptom improvement at discharge than TAU participants on the PCL, F(3, 193) = 15.32, p < .001, b = 6.25, 95% CI [3.06, 9.44], and other measures. In addition, significantly more patients treated with CPT were classified as "recovered" or "improved" at discharge, chi2(1, N = 197) = 4.93, p = .032. Conclusions: There is still room for improvement, as substantial numbers of veterans continue to experience significant symptoms even after treatment with CPT in a residential program. However, CPT appears to produce significantly more symptom improvement than treatment conducted before the implementation of CPT. The implementation of this empirically supported treatment in VHA settings is both feasible and sustainable and is likely to improve care for male veterans with military-related PTSD. [Copyright American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Alvarez, Jennifer AU - McLean, Caitlin AU - Harris, Alex H S AU - Rosen, Craig S AU - Ruzek, Josef I AU - Kimerling, Rachel AD - Department of Veterans Affairs Palo Alto Health Care System jennifer.alvarez@va.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 590 EP - 599 PB - American Psychological Association, Washington DC VL - 79 IS - 5 SN - 0022-006X, 0022-006X KW - Group therapy KW - Veterans KW - Symptoms KW - Posttraumatic stress disorder KW - Men KW - Cognitive processing KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023091193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=The+comparative+effectiveness+of+cognitive+processing+therapy+for+male+veterans+treated+in+a+VHA+posttraumatic+stress+disorder+residential+rehabilitation+program.&rft.au=Alvarez%2C+Jennifer%3BMcLean%2C+Caitlin%3BHarris%2C+Alex+H+S%3BRosen%2C+Craig+S%3BRuzek%2C+Josef+I%3BKimerling%2C+Rachel&rft.aulast=Alvarez&rft.aufirst=Jennifer&rft.date=2011-10-01&rft.volume=79&rft.issue=5&rft.spage=590&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2Fa0024466 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Symptoms; Veterans; Men; Group therapy; Cognitive processing DO - http://dx.doi.org/10.1037/a0024466 ER - TY - JOUR T1 - Disparities in Health Behaviors and Chronic Conditions in Health Care Providers in the Veterans Health Administration AN - 1020838278; 16044327 AB - Objective: To determine baseline prevalence of health behaviors and chronic health conditions in Veterans Health Administration (VHA) employees and highlight disparities by occupation group. Methods: There were 29,834 responses to the survey. Age-standardized prevalence estimates for VHA employees were compared to national estimates from BRFSS surveys. The VHA estimates were analyzed for physicians and dentists; physician assistants and nurse practitioners; registered nurses; licensed practical nurses and nursing assistants; other clinical; nonclinical; and wage grade staff. Multilevel regression explored the effect of worksite. Results: The VHA employees have higher rates of unhealthy behaviors and chronic health conditions than US adults, except for smoking. Results illustrated significant disparities between occupation groups by demographics and variability by worksite. Conclusions: Veterans Health Administration's population appears less healthy than the US general population. Disparities between occupation groups support the establishment of targeted health promotion programs, with attention paid to differences in local culture. JF - Journal of Occupational and Environmental Medicine AU - Schult, T M AU - Awosika, E R AU - Hodgson, MJ AU - Dyrenforth, S AD - Veterans Health Administration, One Veterans Dr, Bldg 68 Room 138 (V68) Minneapolis, MN 55417, USA, tamara.schult@va.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1134 EP - 1145 VL - 53 IS - 10 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - demography KW - Local culture KW - Health care KW - dentistry KW - Behavior KW - health promotion KW - nursing KW - Medical personnel KW - Working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020838278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Disparities+in+Health+Behaviors+and+Chronic+Conditions+in+Health+Care+Providers+in+the+Veterans+Health+Administration&rft.au=Schult%2C+T+M%3BAwosika%2C+E+R%3BHodgson%2C+MJ%3BDyrenforth%2C+S&rft.aulast=Schult&rft.aufirst=T&rft.date=2011-10-01&rft.volume=53&rft.issue=10&rft.spage=1134&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31822b8379 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - demography; Local culture; Behavior; dentistry; Health care; health promotion; nursing; Working conditions; Medical personnel DO - http://dx.doi.org/10.1097/JOM.0b013e31822b8379 ER - TY - JOUR T1 - Lentiviral-based BMP4 in vivo gene transfer strategy increases pull-out tensile strength without an improvement in the osteointegration of the tendon graft in a rat model of biceps tenodesis AN - 1017970328; 16707124 AB - Background The present study aimed to develop a rat model of biceps tenodesis and to assess the feasibility of a lentiviral (LV)-based bone morphogenetic protein (BMP) 4 in vivo gene transfer strategy for healing of biceps tenodesis. Methods A rat model of biceps tenodesis was developed with an interference-fit open surgical technique. A LV vector expressing a BMP4 gene or Delta *b-galactosidase ( Delta *b-gal) control gene was applied to the bone tunnel and the tendon graft before its insertion into the bone tunnel. Osteointegration was assessed by histology and pull-out tensile strength was measured by a biomechanical test suitable for small rat biceps tendon grafts. Results Neo-chondrogenesis was seen at the tendon-bone interface of LV-BMP4-treated but not control rats. The LV-BMP4-treated rats showed 32% (p<0.05) more newly-formed trabecular bone at the tendon-bone junction than the LV- Delta *b-gal-treated controls after 3weeks. However, the sites of neo-chondrogenesis and new bone formation in the LV-BMP4-treated tenodesis were highly spotty. Although the LV-BMP4 strategy did not promote bony integration of the tendon graft, it yielded a 29.5?11.8% (p=0.066) increase in improvement the pull-out strength of rat biceps tendons compared to the LV- Delta *b-gal treatment after 5weeks. Conclusions Although the LV-BMP4 in vivo gene transfer strategy did not enhance osteointegration of the tendon graft, it yielded a marked improvement in the return of the pull-out strength of the tendon graft. This presumably was largely a result of the bone formation effect of BMP4 that traps or anchors the tendon graft onto the bony tunnel. Published 2011. This article is a US Government work and is in the public domain in the USA. JF - Journal of Gene Medicine AU - Anon., Anon AD - Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA, USA, william.lau@med.va.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 511 EP - 521 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 13 IS - 10 SN - 1521-2254, 1521-2254 KW - Calcium & Calcified Tissue Abstracts; Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Bone (trabecular) KW - Bone grafts KW - Bone healing KW - Bone morphogenetic protein 4 KW - Bone morphogenetic proteins KW - Gene transfer KW - Integration KW - Osteogenesis KW - Tendons KW - Tensile strength KW - Traps KW - Tunnels KW - osteointegration KW - V 22410:Animal Diseases KW - G 07870:Mammals KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017970328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gene+Medicine&rft.atitle=Lentiviral-based+BMP4+in+vivo+gene+transfer+strategy+increases+pull-out+tensile+strength+without+an+improvement+in+the+osteointegration+of+the+tendon+graft+in+a+rat+model+of+biceps+tenodesis&rft.au=Anon.%2C+Anon&rft.aulast=Anon.&rft.aufirst=Anon&rft.date=2011-10-01&rft.volume=13&rft.issue=10&rft.spage=511&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gene+Medicine&rft.issn=15212254&rft_id=info:doi/10.1002%2Fjgm.1604 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jgm.1604/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-10-08 N1 - SubjectsTermNotLitGenreText - Bone grafts; Tunnels; Bone (trabecular); Bone healing; Integration; Bone morphogenetic proteins; Gene transfer; osteointegration; Traps; Tensile strength; Bone morphogenetic protein 4; Tendons; Osteogenesis DO - http://dx.doi.org/10.1002/jgm.1604 ER - TY - JOUR T1 - Emerging therapies for Clostridium difficile infections AN - 907176153; 15811321 AB - Introduction: Clostridium difficile infection (CDI) is the leading identifiable gastrointestinal disease in healthcare institutions, but the response rates to the two standard therapies for CDI are declining and so innovative therapies are being developed for CDI. The purpose of this paper is to review the data on the efficacy and safety of emerging therapies for CDI and assess their potential for effectiveness based on the clinical phase of development and marketing challenges. Areas covered: Emerging therapies for CDI are reviewed including new antibiotics, peptides, immune regulators, probiotics and toxin binders. PubMed, Medline and Google Scholar and online clinical trial registers are searched from 1976 to 2010 for articles unrestricted by language. Secondary searches by author, manufacturing companies and FDA websites are also performed. Expert opinion: Of the emerging therapies for CDI, several may ultimately reduce the incidence of CDI and the economic burden of this disease on the healthcare system. Several emerging treatments (fidaxomicin, rifaximin and mAbs) show the most promise, although only one is currently being actively developed. Use of other clostridial strains, probiotic strains and immune enhancers have great potential as therapies, but require further development. JF - Expert Opinion on Emerging Drugs AU - McFarland, Lynne V AD - Puget Sound VA HealthCare System, Department of Health Services Research and Development, 1100 Olive Way #1400, S-152, Seattle, WA 98101, USA ++1 206 277 1095; ++1 206 768 5343, lynne.mcfarland@va.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 425 EP - 439 PB - Informa Healthcare VL - 16 IS - 3 SN - 1472-8214, 1472-8214 KW - Microbiology Abstracts B: Bacteriology KW - Data processing KW - Monoclonal antibodies KW - Gastrointestinal tract diseases KW - probiotics KW - Antibiotics KW - Drug development KW - Infection KW - Clinical trials KW - Toxins KW - Reviews KW - Economics KW - Clostridium difficile KW - Language KW - Internet KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907176153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Emerging+Drugs&rft.atitle=Emerging+therapies+for+Clostridium+difficile+infections&rft.au=McFarland%2C+Lynne+V&rft.aulast=McFarland&rft.aufirst=Lynne&rft.date=2011-09-01&rft.volume=16&rft.issue=3&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Expert+Opinion+on+Emerging+Drugs&rft.issn=14728214&rft_id=info:doi/10.1517%2F14728214.2011.571204 L2 - http://www.ingentaconnect.com/content/apl/emd/2011/00000016/00000003/art00003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Data processing; Monoclonal antibodies; Gastrointestinal tract diseases; probiotics; Drug development; Antibiotics; Infection; Clinical trials; Toxins; Reviews; Economics; Language; Internet; Clostridium difficile DO - http://dx.doi.org/10.1517/14728214.2011.571204 ER - TY - JOUR T1 - Sexual Assault and Substance Use in Male Veterans Receiving a Brief Alcohol Intervention AN - 902371719; 15848034 AB - Objective: Many studies have documented the link between substance use and a history of sexual assault in women; however, few studies have examined this relationship in men. The purpose of this study was to explore the rates of sexual assault in a sample of male veterans reporting alcohol misuse and to further explore potential differences in alcohol use patterns and alcohol-related characteristics in those with and without a history of sexual assault. We also explored the types of illicit drugs being used in the past 90 days and whether a clinical sample of male veterans reporting sexual assault are at greater odds of using these substances when compared with their peers with no history of sexual assault. Method: Data were collected on a nationwide sample (N = 880) of male veterans receiving care in Veterans Administration outpatient mental health clinics. Results: We found that 9.5% of our sample reported a history of sexual assault, and those with this history reported increased alcohol consumption, a greater number of alcohol-related consequences, and an increased likelihood of using an illicit substance in the past 90 days. The most commonly used illicit substances were cannabis, cocaine, and opiates. Those with sexual assault histories were also more likely to report risk factors that may exacerbate the negative effects of any level of alcohol consumption. Conclusions: Our findings highlight the burden of alcohol and illicit drug use among male veterans and suggest that substance use disorder treatment settings may be a context in which prevalence of a history of sexual assault is high. Our findings further support prior call for universal screening for sexual assault among this population. JF - Journal of Studies on Alcohol and Drugs AU - Cucciare, MA AU - Ghaus, S AU - Weingardt, K R AU - Frayne, S M AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, Stanford University School of Medicine, 795 Willow Road (152), Menlo Park, California 94025, USA, michael.cucciare@va.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 693 EP - 700 VL - 72 IS - 5 SN - 1937-1888, 1937-1888 KW - Risk Abstracts KW - Alcohol KW - Historical account KW - substance use KW - cocaine KW - males KW - sexual assault KW - Risk factors KW - intervention KW - Cannabis KW - Drugs KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902371719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Sexual+Assault+and+Substance+Use+in+Male+Veterans+Receiving+a+Brief+Alcohol+Intervention&rft.au=Cucciare%2C+MA%3BGhaus%2C+S%3BWeingardt%2C+K+R%3BFrayne%2C+S+M&rft.aulast=Cucciare&rft.aufirst=MA&rft.date=2011-09-01&rft.volume=72&rft.issue=5&rft.spage=693&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Historical account; Alcohol; intervention; Risk factors; cocaine; substance use; males; Drugs; sexual assault; Cannabis ER - TY - JOUR T1 - Potentially Traumatic Events in a Transgender Sample: Frequency and Associated Symptoms AN - 899137363; 15714212 AB - The frequency of potentially traumatic events (PTEs) and associated symptoms were examined in a cross-sectional study of 97 transgender participants who had been classified as male at birth. A total of 98% reported at least one PTE and 91% endorsed multiple events. Of those with PTE exposures, 42% reported that at least one event was transgender bias-related. Among those with PTEs, 17.8% endorsed clinically significant symptoms of PTSD and 64% reported clinically significant depressive symptoms. The percentage of transgender individuals in this sample reporting clinically significant symptoms was higher than in trauma-exposed samples of men in the general population, but roughly similar to rates of female trauma survivors. Amount of time spent dressed consistent with gender identity was associated with increased risk for PTE exposure and was positively associated with mental health symptoms. No differences in symptoms were observed when comparing those with and without transgender bias-related PTEs. Overall, transgender individuals endorsed high prevalence of PTE exposure along with elevated PTSD and depressive symptoms, when compared to other traumatized populations. JF - Traumatology AU - Shipherd, Jillian C AU - Maguen, Shira AU - Skidmore, WChristopher AU - Abramovitz, Sarah M AD - VA Boston Healthcare System, Boston, MA, National Center for PTSD, Women's Health Sciences Division, Boston, MA, Boston University School of Medicine; Boston, MA, Jillian.Shipherd@va.gov Jillian.Shipherd@va.gov Jillian.Shipherd@va.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 56 EP - 67 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 17 IS - 2 SN - 1534-7656, 1534-7656 KW - Genetics Abstracts; Risk Abstracts KW - Birth KW - Depression KW - Gender KW - Mental disorders KW - Post-traumatic stress disorder KW - Trauma KW - bisexuality KW - depression KW - mental disorders KW - posttraumatic stress disorder KW - G 07880:Human Genetics KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899137363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traumatology&rft.atitle=Potentially+Traumatic+Events+in+a+Transgender+Sample%3A+Frequency+and+Associated+Symptoms&rft.au=Shipherd%2C+Jillian+C%3BMaguen%2C+Shira%3BSkidmore%2C+WChristopher%3BAbramovitz%2C+Sarah+M&rft.aulast=Shipherd&rft.aufirst=Jillian&rft.date=2011-09-01&rft.volume=17&rft.issue=2&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F1534765610395614 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Number of references - 73 N1 - Last updated - 2013-04-05 N1 - SubjectsTermNotLitGenreText - Birth; Mental disorders; Depression; Post-traumatic stress disorder; Trauma; posttraumatic stress disorder; Gender; bisexuality; mental disorders; depression DO - http://dx.doi.org/10.1177/1534765610395614 ER - TY - JOUR T1 - Approach to the evaluation of a patient with an increased serum osmolal gap and high-anion-gap metabolic acidosis. AN - 884844985; 21794966 AB - An increase in serum osmolality and serum osmolal gap with or without high-anion-gap metabolic acidosis is an important clue to exposure to one of the toxic alcohols, which include methanol, ethylene glycol, diethylene glycol, propylene glycol, or isopropanol. However, the increase in serum osmolal gap and metabolic acidosis can occur either together or alone depending on several factors, including baseline serum osmolal gap, molecular weight of the alcohol, and stage of metabolism of the alcohol. In addition, other disorders, including diabetic or alcoholic ketoacidosis, acute kidney injury, chronic kidney disease, and lactic acidosis, can cause high-anion-gap metabolic acidosis associated with an increased serum osmolal gap and therefore should be explored in the differential diagnosis. It is essential for clinicians to understand the value and limitations of osmolal gap to assist in reaching the correct diagnosis and initiating appropriate treatment. In this teaching case, we present a systematic approach to diagnosing high serum osmolality and increased serum osmolal gap with or without high-anion-gap metabolic acidosis. Published by Elsevier Inc. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Kraut, Jeffrey A AU - Xing, Shelly Xiaolei AD - Medical and Research Services Veterans Administration Greater Los Angeles (VHAGLA) Healthcare System, Los Angeles, CA 90073, USA. jkraut@ucla.edu Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 480 EP - 484 VL - 58 IS - 3 KW - Propylene Glycol KW - 6DC9Q167V3 KW - Ethylene Glycol KW - FC72KVT52F KW - Index Medicus KW - Osmolar Concentration KW - Acid-Base Equilibrium KW - Drug Interactions KW - Humans KW - Middle Aged KW - Propylene Glycol -- poisoning KW - Male KW - Ethylene Glycol -- poisoning KW - Diabetic Ketoacidosis -- blood KW - Diabetic Ketoacidosis -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/884844985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Approach+to+the+evaluation+of+a+patient+with+an+increased+serum+osmolal+gap+and+high-anion-gap+metabolic+acidosis.&rft.au=Kraut%2C+Jeffrey+A%3BXing%2C+Shelly+Xiaolei&rft.aulast=Kraut&rft.aufirst=Jeffrey&rft.date=2011-09-01&rft.volume=58&rft.issue=3&rft.spage=480&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=1523-6838&rft_id=info:doi/10.1053%2Fj.ajkd.2011.05.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-27 N1 - Date created - 2011-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1053/j.ajkd.2011.05.018 ER - TY - JOUR T1 - BMI trajectory groups in veterans of the Iraq and Afghanistan wars AN - 1761652643; 201209400 AB - Objective: The study sought to determine BMI trajectories in Iraq/Afghanistan veterans over 6 years and to examine sociodemographic factors associated with BMI trajectory membership. Methods: Our study sample included 16,656 veterans post-deployment and entering the Veteran Healthcare Administration (VHA) healthcare system. We used national VHA administrative sociodemographic data, tracked veteran BMI for 6 years, and used trajectory modeling to identify BMI trajectories and sociodemographic characteristics associated with trajectory membership. Results: Five trajectory groups determined in the full sample were primarily differentiated by their post-deployment initial BMI: "healthy" (14.1%), "overweight" (36.3%), "borderline obese" (27.9%), "obese" (15.7%), and "severely obese" (6.0). Being female, younger, and white were associated with lower initial BMI trajectory group membership (p's .05). Greater observed BMI increase was associated with higher initial BMI across groups (0.6, 0.8, 1.5, 1.9, 2.7). Gender specific trajectory models found that male Veterans with higher education and white female Veterans were associated with the lowest initial BMI group (p's .05). Conclusions: Higher post-deployment BMI was associated with greater BMI gain over time for both male and female veterans. Older age is associated with higher BMI regardless of gender. Education level and racial status are differentially related to BMI trajectory by gender. [Copyright Elsevier B.V.] JF - Preventive Medicine AU - Rosenberger, Patricia H AU - Ning, Yuming AU - Brandt, Cynthia AU - Allore, Heather AU - Haskell, Sally AD - VA Connecticut Healthcare System, West Haven, CT, USA patricia.rosenberger@va.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 149 EP - 154 PB - Elsevier Ltd, The Netherlands VL - 53 IS - 3 SN - 0091-7435, 0091-7435 KW - Obesity Overweight OEF/OIF veterans Trajectory modeling KW - Veterans KW - Obesity KW - Membership KW - Gender KW - Body Mass Index KW - Iraq KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761652643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=BMI+trajectory+groups+in+veterans+of+the+Iraq+and+Afghanistan+wars&rft.au=Rosenberger%2C+Patricia+H%3BNing%2C+Yuming%3BBrandt%2C+Cynthia%3BAllore%2C+Heather%3BHaskell%2C+Sally&rft.aulast=Rosenberger&rft.aufirst=Patricia&rft.date=2011-09-01&rft.volume=53&rft.issue=3&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2011.07.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Body Mass Index; Veterans; Obesity; Gender; Iraq; Membership DO - http://dx.doi.org/10.1016/j.ypmed.2011.07.001 ER - TY - JOUR T1 - Partnering With Communities to Address the Mental Health Needs of Rural Veterans AN - 1748687059 AB - Purpose: Many veterans who face mental illness and live in rural areas never obtain the mental health care they need. To address these needs, it is important to reach out to community stakeholders who are likely to have frequent interactions with veterans, particularly those returning from Operations Enduring and Iraqi Freedom (OEF/OIF). Methods: Three community stakeholder groups—clergy, postsecondary educators, and criminal justice personnel—are of particular importance for OEF/OIF veterans living in rural areas and may be more likely to come into contact with rural veterans struggling with mental illness or substance abuse than the formal health care system. This article briefly describes the conceptualization, development, initial implementation, and early evaluation of a Veterans Affairs (VA) medical center-based program designed to improve engagement in, and access to, mental health care for veterans returning to rural areas. Findings: One year since initial funding, 90 stakeholders have attended formal training workshops (criminal justice personnel = 36; educators = 31; clergy = 23). Two training formats (a 2-hour workshop and an intensive 2.5-day workshop) have been developed and provided to clergy in 1 rural county with another county scheduled for training. A veteran outreach initiative, which has received 32 referrals for various student services, has been established on 4 rural college campuses. A Veterans Treatment Court also has been established with 16 referrals for eligibility assessments. Conclusions: While this pilot program is in the early stages of evaluation, its success to date has encouraged program and VA clinical leadership to expand beyond the original sites. JF - The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association AU - Kirchner, JoAnn E AU - Farmer, Mary Sue AU - Shue, Valorie M AU - Blevins, Dean AU - Sullivan, Greer AD - United States Department of Veterans Affairs Mental Health Quality Enhancement Research Initiative, North Little Rock, Arkansas., University of Arkansas for Medical Sciences, Little Rock, Arkansas., United States Department of Veterans Affairs Health Services Research and Development Center for Mental Healthcare and Outcomes Research, North Little Rock, Arkansas. ; United States Department of Veterans Affairs South Central Mental Illness Research Education Clinical Center, North Little Rock, Arkansas. ; University of Arkansas for Medical Sciences, Little Rock, Arkansas. ; United States Department of Veterans Affairs South Central Mental Illness Research Education Clinical Center, North Little Rock, Arkansas., University of Arkansas for Medical Sciences, Little Rock, Arkansas., United States Department of Veterans Affairs Health Services Research and Development Center for Mental Healthcare and Outcomes Research, North Little Rock, Arkansas. ; United States Department of Veterans Affairs Mental Health Quality Enhancement Research Initiative, North Little Rock, Arkansas.; University of Arkansas for Medical Sciences, Little Rock, Arkansas.; United States Department of Veterans Affairs Health Services Research and Development Center for Mental Healthcare and Outcomes Research, North Little Rock, Arkansas. Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 416 EP - 424 CY - Washington PB - Wiley Subscription Services, Inc. VL - 27 IS - 4 SN - 0890-765X KW - Public Health And Safety KW - Campuses KW - Freedom KW - Access KW - Substance Abuse KW - Clergy KW - Teachers KW - Services KW - Concept Formation KW - Criminal Justice KW - Health Care Services Policy KW - Illness KW - Implementation KW - Mental Illness KW - Interest Groups KW - Training KW - Leadership KW - Mental Health Services KW - Treatment Programs KW - Rural Areas KW - Veterans KW - Mental health services KW - Mental illness KW - Outreach programmes KW - Personnel KW - Referrals KW - Rural areas KW - Rural communities KW - Stakeholders KW - Substance abuse KW - Workshops KW - Clinical leadership KW - Colleges KW - Community mental health services KW - Conceptualization KW - Criminal justice KW - Eligibility KW - Financing KW - Health KW - Health care KW - Health needs KW - Mental health care KW - Iraq UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1748687059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.atitle=Partnering+With+Communities+to+Address+the+Mental+Health+Needs+of+Rural+Veterans&rft.au=Kirchner%2C+JoAnn+E%3BFarmer%2C+Mary+Sue%3BShue%2C+Valorie+M%3BBlevins%2C+Dean%3BSullivan%2C+Greer&rft.aulast=Kirchner&rft.aufirst=JoAnn&rft.date=2011-09-01&rft.volume=27&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2011.00362.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); PAIS Index N1 - Copyright - Copyright Wiley Subscription Services, Inc. Sep 2011 N1 - Date revised - 2014-11-10 N1 - Last updated - 2017-01-06 N1 - SubjectsTermNotLitGenreText - Iraq DO - http://dx.doi.org/10.1111/j.1748-0361.2011.00362.x ER - TY - JOUR T1 - Reducing the Burden of Mental Illness in Military Veterans: Commentary on Kazdin and Blase (2011) AN - 1373489741; 201314394 AB - Clinical psychology as a profession owes much to the recognition of the psychosocial needs of servicemen and women returning from World War II and the Korean conflict. The current conflicts in Iraq and Afghanistan represent another opportunity for substantial advancements in assessment and treatment practices. Stimulated by the prescient article by Kazdin and Blase (2011), we briefly describe innovations in evidence-based practices currently being implemented in the Veterans Health Administration to best serve the more than 2 million returning servicemen and women. The largest healthcare system in the nation, the U.S. Department of Veterans Affairs began a wide range of innovations early this century to include dissemination of evidence-based mental health treatments, the use of anonymous Internet-based interventions to reach large numbers of military personnel who may not otherwise present for mental health service, the use of videoconferencing to deliver assessment and treatment to individuals residing in remote locations, and the use of laypersons (e.g., peers) for treatment delivery. In addition to describing the strengths of these efforts to reduce mental health burden, we also discuss persisting barriers and limitations of these innovative efforts within this system of healthcare. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Perspectives on Psychological Science AU - Sloan, Denise M AU - Marx, Brian P AU - Keane, Terence M AD - National Center for PTSD, VA Boston Healthcare System e-mail:denise.sloan@va.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 503 EP - 506 PB - Sage Publications, Thousand Oaks CA VL - 6 IS - 5 SN - 1745-6916, 1745-6916 KW - dissemination, implementation, telehealth KW - Veterans KW - Health care KW - Women KW - Servicemen KW - Mental health KW - Innovations KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1373489741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+on+Psychological+Science&rft.atitle=Reducing+the+Burden+of+Mental+Illness+in+Military+Veterans%3A+Commentary+on+Kazdin+and+Blase+%282011%29&rft.au=Sloan%2C+Denise+M%3BMarx%2C+Brian+P%3BKeane%2C+Terence+M&rft.aulast=Sloan&rft.aufirst=Denise&rft.date=2011-09-01&rft.volume=6&rft.issue=5&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Perspectives+on+Psychological+Science&rft.issn=17456916&rft_id=info:doi/10.1177%2F1745691611416995 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Innovations; Servicemen; Women; Veterans; Mental health; Health care DO - http://dx.doi.org/10.1177/1745691611416995 ER - TY - JOUR T1 - Chronically Homeless Women Report High Rates of Substance Use Problems Equivalent to Chronically Homeless Men AN - 1221434283; 201228425 AB - Introduction: The U.S. federal government recently committed itself to ending chronic homelessness within 5 years. Women constitute one out of four chronically homeless adults and represent a particularly vulnerable group, but have been little studied. To identify potentially unique needs in this group, we report characteristics and 2-year outcomes in a large sample of male and female chronically homeless adults participating in a multisite, supportive housing program. Methods: Men and women participating in the outcome evaluation of the 11-site Collaborative Initiative on Chronic Homelessness (n = 714) supportive housing program and who received at least one follow-up assessment were compared on baseline characteristics and up to 2-year follow-up outcomes. Mixed model multivariate regression adjusted outcome findings for baseline group differences. Results: Few significant baseline differences existed between males and females, with both sexes self-reporting very high rates of lifetime mental health (83% women, 74% men) and substance use (68% women, 73% men) problems. Throughout the 2-year follow-up, both men and women dramatically increased the number of days housed, showed minimal changes in substance use patterns, and had modest improvements in mental health outcomes, without significant differences between genders. Conclusion: Unlike other U.S. populations, chronically homeless adults do not demonstrate substantial gender differences on mental health or addiction problems. Policy and service delivery must address these remarkably high rates of substance use and mental illness. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Edens, Ellen Lockard AU - Mares, Alvin S AU - Rosenheck, Robert A AD - 950 Campbell Ave, West Haven, CT 06516. Phone: 203-932-5711, ext. 4123; Fax: 203.937-3472 ellen.edens@va.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 383 EP - 389 PB - Elsevier Science, New York NY VL - 21 IS - 5 SN - 1049-3867, 1049-3867 KW - Chronically KW - Housing KW - Homeless people KW - Mental health KW - Substance abuse KW - Homelessness KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221434283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Chronically+Homeless+Women+Report+High+Rates+of+Substance+Use+Problems+Equivalent+to+Chronically+Homeless+Men&rft.au=Edens%2C+Ellen+Lockard%3BMares%2C+Alvin+S%3BRosenheck%2C+Robert+A&rft.aulast=Edens&rft.aufirst=Ellen&rft.date=2011-09-01&rft.volume=21&rft.issue=5&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.03.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Chronically; Substance abuse; Homeless people; Mental health; Housing; Homelessness DO - http://dx.doi.org/10.1016/j.whi.2011.03.004 ER - TY - JOUR T1 - A New Multidimensional Model of Successful Aging: Perceptions of Japanese American Older Adults AN - 1125220980; 201207391 AB - This study examined the concept of successful aging using an ethnographic grounded-theory approach. Seventy-seven Japanese American older adults participated in focus groups. Participants perceived successful aging as optimal functioning in the following areas: Physical health, psychological health, cognitive functioning, socialization, spirituality, and financial security. The content of each dimension represents both culture-specific and culturally-universal elements. This new multidimensional model of successful aging was compared to Rowe and Kahn's (The Gerontologist 37:433-440, 1997) and Phelan et al.'s frameworks (Journal of the American Geriatric Society 52:211-216, 2004) of successful aging. The model of successful aging generated from this study appears to be more comprehensive than existing models and incorporates sociocultural experiences. Adapted from the source document. JF - Journal of Cross-Cultural Gerontology AU - Iwamasa, Gayle Y AU - Iwasaki, Michiko AD - Department of Veterans Affairs, Veterans Health Administration, Office of Mental Health Operations, 9152 Kent Avenue, Building 401, Indianapolis, IN, 46216, USA gayle.iwamasa@va.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 261 EP - 278 PB - Springer, Dordrecht The Netherlands VL - 26 IS - 3 SN - 0169-3816, 0169-3816 KW - Sociocultural Factors KW - Religiosity KW - Aging KW - Geriatrics KW - Ethnography KW - Elderly KW - Asian Americans KW - Health KW - Cognitive Functioning KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125220980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cross-Cultural+Gerontology&rft.atitle=A+New+Multidimensional+Model+of+Successful+Aging%3A+Perceptions+of+Japanese+American+Older+Adults&rft.au=Iwamasa%2C+Gayle+Y%3BIwasaki%2C+Michiko&rft.aulast=Iwamasa&rft.aufirst=Gayle&rft.date=2011-09-01&rft.volume=26&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cross-Cultural+Gerontology&rft.issn=01693816&rft_id=info:doi/10.1007%2Fs10823-011-9147-9 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JCCGEB N1 - SubjectsTermNotLitGenreText - Aging; Elderly; Health; Cognitive Functioning; Sociocultural Factors; Ethnography; Asian Americans; Religiosity; Geriatrics DO - http://dx.doi.org/10.1007/s10823-011-9147-9 ER - TY - JOUR T1 - Vowel Identification by Listeners with Hearing Impairment in Response to Variation in Formant Frequencies AN - 925724888; 201202215 AB - Purpose: This study examined the influence of presentation level and mild-to-moderate hearing loss on the identification of a set of vowel tokens systematically varying in the frequency locations of their second and third formants. Method: Five listeners with normal hearing (NH listeners) and five listeners with hearing impairment (HI listeners) identified synthesized vowels that represented both highly identifiable and ambiguous examples of /I/, /(upsilon)/, and /[revopenehook]/. Results: Response patterns of NH listeners showed significant changes, with an increase in presentation level from 75 dB SPL to 95 dB SPL, including increased category overlap. HI listeners, listening only at the higher level, showed greater category overlap than normal and overall identification patterns that differed significantly from those of NH listeners. Excitation patterns based on estimates of auditory filters suggested smoothing of the internal representations, resulting in impaired formant resolution. Conclusions: Both increased presentation level for NH listeners and the presence of hearing loss produced a significant change in vowel identification for this stimulus set. Major differences were observed between NH listeners and HI listeners in vowel category overlap and in the sharpness of boundaries between vowel tokens. It is likely that these findings reflect imprecise internal spectral representations due to reduced frequency selectivity. Adapted from the source document JF - Journal of Speech, Language, and Hearing Research AU - Molis, Michelle R AU - Leek, Marjorie R AD - National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Oregon michelle.molis@va.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 1211 EP - 1223 VL - 54 IS - 4 SN - 1092-4388, 1092-4388 KW - Formants (25300) KW - Speech Perception (82700) KW - Hearing Disorders (31450) KW - Sound Identification (80450) KW - Vowels (95650) KW - Speech Sounds (82890) KW - Sensorineural Hearing Loss (77290) KW - article KW - 6310: hearing-pathological and normal; hearing-pathological and normal KW - 4017: psycholinguistics; psychoacoustics/speech perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925724888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=Vowel+Identification+by+Listeners+with+Hearing+Impairment+in+Response+to+Variation+in+Formant+Frequencies&rft.au=Molis%2C+Michelle+R%3BLeek%2C+Marjorie+R&rft.aulast=Molis&rft.aufirst=Michelle&rft.date=2011-08-01&rft.volume=54&rft.issue=4&rft.spage=1211&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Sensorineural Hearing Loss (77290); Hearing Disorders (31450); Speech Sounds (82890); Vowels (95650); Speech Perception (82700); Formants (25300); Sound Identification (80450) ER - TY - JOUR T1 - Older Men's Explanatory Model for Osteoporosis AN - 919903219; 201203379 AB - Purpose: To explore the nature of men's experiences of osteoporosis by developing an understanding of men's explanatory models. Design and Methods: This descriptive study invited community-residing male osteoporosis patients aged 50+ to participate in interviews about osteoporosis. Participants were recruited from a hospital-affiliated bone clinic. Men completed a questionnaire on demographic, medication, and fracture-related information, and descriptive statistics were calculated using Statistical Package for the Social Sciences. Interviews elicited the 5 domains of men's explanatory model (Kleinman, 1987) and open-ended information regarding men's experiences living with this disorder. Narrative data were analyzed both for content and inductively. Results: Men's narratives demonstrate that an osteoporosis diagnosis is accompanied by negative psychosocial sequelae in this population. Men defined it as a disease of the bone that may increase the likelihood of fracture and that may cause pain. Participants reported that osteoporosis is diagnosed by bone mineral density (BMD) score and that disease progression is measured by a decrease in BMD and an increase in pain or new fractures. Men described a reluctance to take medications, dissatisfaction with side effects, and a perception that osteoporosis treatment in men had little basis in long-term medication efficacy or safety data. They viewed osteoporosis as a degenerative chronic disease with an overall stable course. Implications: Participants' explanatory models for osteoporosis are substantively different than clinical models. These differences provide a foundation for exploring the importance of gender to osteoporosis outcomes, a context for making sense of men's bone health behavior, and a clear case for an increase in advocacy and educational efforts for men who have or are at risk for osteoporosis. Adapted from the source document. JF - The Gerontologist AU - Solimeo, Samantha L AU - Weber, Thomas J AU - Gold, Deborah T AD - Center for Comprehensive Access and Delivery Research and Evaluation (CADRE), Iowa City VA Medical Center (152), 601 Highway 6 West, Iowa City, IA 52246-2208 samantha.solimeo@va.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 530 EP - 539 PB - Gerontological Society of America, Washington DC VL - 51 IS - 4 SN - 0016-9013, 0016-9013 KW - Masculinity, Fracture, Qualitative, Psychosocial, Risk KW - Risk KW - Males KW - Health Behavior KW - Patients KW - Diseases KW - Discontent KW - Sex KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919903219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=Older+Men%27s+Explanatory+Model+for+Osteoporosis&rft.au=Solimeo%2C+Samantha+L%3BWeber%2C+Thomas+J%3BGold%2C+Deborah+T&rft.aulast=Solimeo&rft.aufirst=Samantha&rft.date=2011-08-01&rft.volume=51&rft.issue=4&rft.spage=530&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/10.1093%2Fgeront%2Fgnq123 LA - English DB - Sociological Abstracts N1 - Date revised - 2014-02-21 N1 - Number of references - 33 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Males; Diseases; Patients; Sex; Discontent; Health Behavior; Risk DO - http://dx.doi.org/10.1093/geront/gnq123 ER - TY - JOUR T1 - Susceptibility of hamsters to infection by historic and epidemic BI Clostridium difficile strains during daily administration of three fluoroquinolones AN - 907165950; 15705681 AB - The recent epidemic of Clostridium difficile infection (CDI) has been attributed largely to the REA strain group BI (aka NAP1/027). Current isolates of the BI group differ from historic non-epidemic BI strains in that they have developed resistance to the newer fluoroquinolone (FQ), moxifloxacin. The acquisition of moxifloxacin resistance has been associated with the rise in frequency of CDI caused by these isolates. In order to explore the effect of FQ resistance on CDI we compared colonization and mortality in hamsters challenged with a historic (BI1 - susceptible to moxifloxacin) and a recent epidemic (BI17 - resistant to moxifloxacin) BI strain of CD during continuous administration of 3 different FQs. Methods: Groups of 6 hamsters were treated with a 5 day course of ciprofloxacin, levofloxacin, or moxifloxacin given orally once per day. Each hamster was then challenged with 1 x 10 super(4 CFU of either BI1 or BI17 on day 3 or day 5. Colonization and time to death were recorded. Results: Colonization efficiency (CE) following moxifloxacin (92%) was significantly greater than following levofloxacin (50%, p 0.01) or ciprofloxacin (42%, p 0.01) for both strains combined. The CE of BI17 was higher than BI1 for ciprofloxacin (67% vs 17%, p = 0.04) and levofloxacin (83% vs 17%, p 0.01), but not moxifloxacin (100% and 83%, p = 0.48) administration. BI17 also showed a shorter time from inoculation to death than BI1 following moxifloxacin administration (1.8 days vs 3.9 days, p 0.01). Moxifloxacin shortened the time from inoculation to death compared to ciprofloxacin in hamsters challenged with BI17 (1.8 days vs 4.0 days, p 0.01) but not levofloxacin (1.8 days vs 2.0 days, p = NS). Conclusions: For the epidemic BI17 strain, ciprofloxacin, levofloxacin and moxifloxacin have similar colonization rates, suggesting that the acquisition of high-level FQ resistance increases colonization rates in association with any FQ. Historic strain BI1 which does not carry high-level FQ resistance colonized efficiently only in the presence of moxifloxacin, possibly explaining lower rates of CDI historically prior to the widespread clinical use of moxifloxacin (and gatifloxacin). Current high rates and severity of CDI from 2000 to 2010 may in part be associated with the acquisition of high-level FQ resistance in BI strains and higher patient exposure rates of all FQs, especially moxifloxacin.) JF - Anaerobe AU - Phillips, STyler AU - Nagaro, Kristin AU - Sambol, Susan P AU - Johnson, Stuart AU - Gerding, Dale N Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 166 EP - 169 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 17 IS - 4 SN - 1075-9964, 1075-9964 KW - Microbiology Abstracts B: Bacteriology KW - Mortality KW - Epidemics KW - Fluoroquinolones KW - Levofloxacin KW - Infection KW - Gatifloxacin KW - Colonization KW - Ciprofloxacin KW - Moxifloxacin KW - Colony-forming cells KW - Inoculation KW - Clostridium difficile KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907165950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Susceptibility+of+hamsters+to+infection+by+historic+and+epidemic+BI+Clostridium+difficile+strains+during+daily+administration+of+three+fluoroquinolones&rft.au=Phillips%2C+STyler%3BNagaro%2C+Kristin%3BSambol%2C+Susan+P%3BJohnson%2C+Stuart%3BGerding%2C+Dale+N&rft.aulast=Phillips&rft.aufirst=STyler&rft.date=2011-08-01&rft.volume=17&rft.issue=4&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=10759964&rft_id=info:doi/10.1016%2Fj.anaerobe.2011.03.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; Ciprofloxacin; Colonization; Epidemics; Fluoroquinolones; Moxifloxacin; Colony-forming cells; Levofloxacin; Inoculation; Infection; Gatifloxacin; Clostridium difficile DO - http://dx.doi.org/10.1016/j.anaerobe.2011.03.015 ER - TY - JOUR T1 - A Study of Self-Injurious and Suicidal Behavior in a Veteran Population AN - 902097267; 201119867 AB - This patient safety improvement study was conducted (1) to establish a database of intentional patient self-injuries and suicidal behavior among veterans in a large urban VA health care system, and (2) to investigate whether there were demographic and/or clinical characteristics of veterans who self-injure that might predict seriousness of suicidal intent and aid in future efforts at prevention. A total of 175 clinician-administered, post self-injury interviews were completed between 2006 and 2008 in a VA health care system in the Northeast. Findings suggest that self-injuries with high suicidal intent were characterized by male gender, older age, planning of self-injury, no wish to be saved, and a negative feeling about having survived. Additional results indicated that staff ratings of patient intent to die were significantly lower than patient self-rated intent to die, a finding that gives rise to questions of whether staff may tend to underestimate patient suicidal intent. Also, although more than 80% of the veterans in this sample considered their self-injurious actions impulsive, planning of self-injury was significantly associated with higher intent to die. Veterans who completed suicide during the study time period were significantly more likely than those who had nonfatal self-injuries to have experienced combat. The implications of these findings are discussed, including whether combat exposure may lead to an acquired capacity for lethal behaviors such as suicide (Joiner, 2005). [Copyright Elsevier B.V.] JF - Psychological Services AU - Kleespies, Phillip M AU - AhnAllen, Christopher G AU - Knight, Jeffrey A AU - Presskreischer, Benjamin AU - Barrs, Kathryn L AU - Boyd, Briana L AU - Dennis, John P AD - VA Boston Healthcare System phillip.kleespies@va.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 236 EP - 250 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 8 IS - 3 SN - 1541-1559, 1541-1559 KW - self-injury suicidal behavior suicide veterans and self-injury self-harm KW - Veterans KW - Suicidal behaviour KW - Health care KW - Suicide KW - Patient care KW - Selfinjury KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902097267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=A+Study+of+Self-Injurious+and+Suicidal+Behavior+in+a+Veteran+Population&rft.au=Kleespies%2C+Phillip+M%3BAhnAllen%2C+Christopher+G%3BKnight%2C+Jeffrey+A%3BPresskreischer%2C+Benjamin%3BBarrs%2C+Kathryn+L%3BBoyd%2C+Briana+L%3BDennis%2C+John+P&rft.aulast=Kleespies&rft.aufirst=Phillip&rft.date=2011-08-01&rft.volume=8&rft.issue=3&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0024881 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Selfinjury; Veterans; Suicidal behaviour; Health care; Suicide; Patient care DO - http://dx.doi.org/10.1037/a0024881 ER - TY - JOUR T1 - Damage of GABAergic neurons in the medial septum impairs spatial working memory and extinction of active avoidance: effects on proactive interference. AN - 879105851; 20865731 AB - The medial septum and diagonal band (MSDB) are important in spatial learning and memory. On the basis of the excitotoxic damage of GABAergic MSDB neurons, we have recently suggested a role for these neurons in controlling proactive interference. Our study sought to test this hypothesis in different behavioral procedures using a new GABAergic immunotoxin. GABA-transporter-saporin (GAT1-SAP) was administered into the MSDB of male Sprague-Dawley rats. Following surgery, rats were trained in a reference memory water maze procedure for 5 days, followed by a working memory (delayed match to position) water maze procedure. Other rats were trained in a lever-press avoidance procedure after intraseptal GAT1-SAP or sham surgery. Intraseptal GAT1-SAP extensively damaged GABAergic neurons while sparing most cholinergic MSDB neurons. Rats treated with GAT1-SAP were not impaired in acquiring a spatial reference memory, learning the location of the escape platform as rapidly as sham rats. In contrast, GAT1-SAP rats were slower than sham rats to learn the platform location in a delayed match to position procedure, in which the platform location was changed every day. Moreover, GAT1-SAP rats returned to previous platform locations more often than sham rats. In the active avoidance procedure, intraseptal GAT1-SAP impaired extinction but not acquisition of the avoidance response. Using a different neurotoxin and behavioral procedures than previous studies, the results of this study paint a similar picture that GABAergic MSDB neurons are important for controlling proactive interference. Copyright © 2010 Wiley-Liss, Inc. JF - Hippocampus AU - Pang, Kevin C H AU - Jiao, Xilu AU - Sinha, Swamini AU - Beck, Kevin D AU - Servatius, Richard J AD - NeuroBehavioral Laboratory, Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey 07018, USA. kevin.pang@va.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 835 EP - 846 VL - 21 IS - 8 KW - GABA Plasma Membrane Transport Proteins KW - 0 KW - Immunotoxins KW - Ribosome Inactivating Proteins, Type 1 KW - Slc6a1 protein, rat KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Choline O-Acetyltransferase KW - EC 2.3.1.6 KW - saporin KW - EC 3.2.2.22 KW - Index Medicus KW - Animals KW - Maze Learning -- drug effects KW - Space Perception -- physiology KW - Hippocampus -- physiology KW - Maze Learning -- physiology KW - Hippocampus -- metabolism KW - gamma-Aminobutyric Acid -- physiology KW - Disease Models, Animal KW - Ribosome Inactivating Proteins, Type 1 -- administration & dosage KW - Immunotoxins -- administration & dosage KW - Choline O-Acetyltransferase -- immunology KW - Rats KW - Rats, Sprague-Dawley KW - Memory Disorders -- chemically induced KW - GABA Plasma Membrane Transport Proteins -- administration & dosage KW - Male KW - Proactive Inhibition KW - GABAergic Neurons -- drug effects KW - Septum of Brain -- cytology KW - GABAergic Neurons -- physiology KW - Diagonal Band of Broca -- physiology KW - Diagonal Band of Broca -- cytology KW - Septum of Brain -- physiology KW - Memory, Short-Term -- physiology KW - Memory, Short-Term -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879105851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hippocampus&rft.atitle=Damage+of+GABAergic+neurons+in+the+medial+septum+impairs+spatial+working+memory+and+extinction+of+active+avoidance%3A+effects+on+proactive+interference.&rft.au=Pang%2C+Kevin+C+H%3BJiao%2C+Xilu%3BSinha%2C+Swamini%3BBeck%2C+Kevin+D%3BServatius%2C+Richard+J&rft.aulast=Pang&rft.aufirst=Kevin+C&rft.date=2011-08-01&rft.volume=21&rft.issue=8&rft.spage=835&rft.isbn=&rft.btitle=&rft.title=Hippocampus&rft.issn=1098-1063&rft_id=info:doi/10.1002%2Fhipo.20799 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-16 N1 - Date created - 2011-07-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurosci Lett. 1994 May 23;173(1-2):63-6 [7936425] J Neurosci. 1994 Jul;14(7):4507-19 [8027790] Biol Psychiatry. 1995 Oct 15;38(8):539-46 [8562666] Neurobiol Learn Mem. 1996 Jul;66(1):80-4 [8661253] J Exp Anal Behav. 1961 Oct;4:309-16 [13908105] J Comp Physiol Psychol. 1965 Jun;59:466-8 [14313800] Hippocampus. 2005;15(3):381-92 [15630696] Synapse. 2005 Dec 1;58(3):151-64 [16108008] Hippocampus. 2005;15(7):936-49 [16158423] J Neurosci. 2007 Jan 10;27(2):299-303 [17215389] Learn Mem. 2009 May;16(5):279-88 [19380710] J Neurosci. 2009 Jun 3;29(22):7330-40 [19494154] Brain Res Mol Brain Res. 1995 Oct;33(1):7-21 [8774941] Behav Brain Res. 1996 Dec;82(1):93-101 [9021074] Hippocampus. 1996;6(6):693-708 [9034856] J Physiol. 1997 Apr 15;500 ( Pt 2):463-74 [9147330] Neuropharmacology. 1998 Apr-May;37(4-5):481-7 [9704989] Eur J Neurosci. 2001 Dec;14(11):1856-64 [11860481] Hippocampus. 2001;11(6):814-27 [11811676] Trends Neurosci. 1999 Feb;22(2):51-61 [10092043] J Physiol. 2003 Sep 15;551(Pt 3):927-43 [12865506] J Comp Physiol Psychol. 1969 Mar;67(3):352-7 [5787385] Psychol Bull. 1973 Apr;79(4):243-51 [4633560] Physiol Behav. 1975 Jan;14(1):25-30 [1153532] Science. 1978 Jul 14;201(4351):160-3 [663646] Brain Res. 1980 Jan 27;182(2):461-5 [6244044] Nature. 1982 Jun 24;297(5868):681-3 [7088155] Science. 1982 Jul 30;217(4558):408-14 [7046051] Science. 1983 Mar 11;219(4589):1184-90 [6338589] Q J Exp Psychol B. 1983 May;35 (Pt 2):97-118 [6683421] Jpn J Pharmacol. 1985 Jun;38(2):141-51 [4032855] Brain Res. 1985 Oct 28;346(1):8-14 [4052773] J Comp Neurol. 1985 Oct 1;240(1):37-59 [4056104] Physiol Behav. 1985 Jul;35(1):139-43 [4059394] Pharmacol Biochem Behav. 1986 Jun;24(6):1635-8 [3737632] Neurobiol Aging. 1986 Jul-Aug;7(4):287-95 [3528890] Brain Res. 1989 Jan 30;478(2):375-81 [2924136] Neuroscience. 1989;31(3):551-70 [2687720] Behav Brain Res. 1990 Jan 1;36(1-2):127-46 [2302312] Brain Res. 1990 Sep 24;528(1):12-20 [2245328] Behav Neurosci. 1990 Dec;104(6):849-55 [2178347] Behav Neurosci. 1995 Aug;109(4):714-22 [7576215] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/hipo.20799 ER - TY - JOUR T1 - Postoperative cognitive disorders. AN - 875717855; 21716111 AB - The elderly are the fastest growing segment of the population and undergo 25-30% of all surgical procedures. Postoperative cognitive problems are common in older patients following major surgery. The socioeconomic implications of these cognitive disorders are profound; cognitive decline is associated with a loss of independence, a reduction in the quality of life, and death. This review will focus on the two most common cognitive problems following surgery: postoperative delirium and postoperative cognitive dysfunction (POCD). For years, preoperative geriatric consultation/screening was the only intervention proven to decrease postoperative delirium. There are, however, several recent publications indicating that preoperative and postoperative pharmacological and medical (hydration, oxygenation) management can reduce postoperative delirium. Spinal anesthesia with minimal propofol sedation has been shown to decrease the incidence of postoperative delirium in hip-fracture patients. Likewise, dexmedetomidine sedation in mechanically ventilated patients in the ICU is associated with less postoperative delirium and shorter ventilator times. Preoperative levels of education and brain function (cognitive reserve) may predict patients at risk for postoperative cognitive problems. Reduced white matter integrity is reported to place patients at a higher risk for both postoperative delirium and POCD. The etiology of postoperative cognitive problems is unknown, but there is emerging evidence that decreased preoperative cognitive function contributes to the development of postoperative delirium and POCD. There is growing concern that inhalation anesthetics may be neurotoxic to the aging brain, but there are no human data evaluating this hypothesis to date. Randomized controlled trials evaluating interventions to improve long-term cognitive outcomes in elderly patients are urgently needed. JF - Current opinion in critical care AU - Monk, Terri G AU - Price, Catherine C AD - Department of Anesthesiology, Duke University Medical Center, Durham Veterans Administration Medical Center, Durham, North Carolina, USA. Terri.Monk@duke.edu Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 376 EP - 381 VL - 17 IS - 4 KW - Index Medicus KW - Preoperative Care KW - Anesthesia, Spinal KW - Social Class KW - Risk Factors KW - Humans KW - Psychometrics KW - Cognition KW - Delirium -- etiology KW - Cognition Disorders -- etiology KW - Cognition Disorders -- diagnosis KW - Delirium -- diagnosis KW - Postoperative Complications KW - Intensive Care Units -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875717855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+critical+care&rft.atitle=Postoperative+cognitive+disorders.&rft.au=Monk%2C+Terri+G%3BPrice%2C+Catherine+C&rft.aulast=Monk&rft.aufirst=Terri&rft.date=2011-08-01&rft.volume=17&rft.issue=4&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+critical+care&rft.issn=1531-7072&rft_id=info:doi/10.1097%2FMCC.0b013e328348bece LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-10 N1 - Date created - 2011-07-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Neurol. 2008 Dec;64(6):618-27 [19006075] J Bone Joint Surg Am. 2009 Jan;91(1):29-37 [19122076] JAMA. 2009 Feb 4;301(5):489-99 [19188334] Anesthesiology. 2009 Mar;110(3):548-55 [19225398] Anesthesiology. 2009 Apr;110(4):781-7 [19326492] Anesthesiology. 2009 Apr;110(4):788-95 [19326494] Mayo Clin Proc. 2010 Jan;85(1):18-26 [20042557] J Am Geriatr Soc. 2005 Oct;53(10):1658-66 [16181163] Ann Thorac Surg. 2005 Dec;80(6):2126-31 [16305857] Palliat Med. 2006 Jan;20(1):17-23 [16482754] N Engl J Med. 2006 Mar 16;354(11):1157-65 [16540616] J Am Coll Surg. 2006 Nov;203(5):752-7 [17084339] Cochrane Database Syst Rev. 2007;(2):CD005563 [17443600] Aging Clin Exp Res. 2007 Jun;19(3):178-86 [17607084] Anesthesiology. 2008 Jan;108(1):8-17 [18156877] Anesthesiology. 2008 Jan;108(1):18-30 [18156878] J Am Geriatr Soc. 2009 Nov;57(11):2029-36 [19754498] Semin Cardiothorac Vasc Anesth. 2010 Jun;14(2):119-22 [20478952] Acta Anaesthesiol Scand. 2010 Jul;54(6):678-88 [20236093] Am J Geriatr Psychiatry. 2010 Aug;18(8):743-53 [20220599] Curr Opin Crit Care. 2011 Feb;17(1):43-9 [21169829] Anesth Analg. 2011 May;112(5):1186-93 [21415433] Anesth Analg. 2011 May;112(5):1179-85 [21474666] J Anesth. 2011 Jun;25(3):330-6 [21448769] Acta Anaesthesiol Scand. 2001 Mar;45(3):275-89 [11207462] J Am Geriatr Soc. 2001 May;49(5):516-22 [11380742] J Am Geriatr Soc. 2001 May;49(5):523-32 [11380743] JAMA. 2001 Dec 5;286(21):2703-10 [11730446] Acta Anaesthesiol Scand. 2003 Mar;47(3):260-6 [12648190] Anesthesiology. 2004 Sep;101(3):703-9 [15329595] Cochrane Database Syst Rev. 2004;(4):CD000521 [15494999] Ann Intern Med. 1990 Dec 15;113(12):941-8 [2240918] J Am Geriatr Soc. 1991 Jul;39(7):655-62 [2061530] JAMA. 1995 Jul 5;274(1):44-50 [7791257] Lancet. 1998 Mar 21;351(9106):857-61 [9525362] J Am Geriatr Soc. 2005 Sep;53(9):1476-82 [16137275] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MCC.0b013e328348bece ER - TY - JOUR T1 - Posttraumatic Stress Disorder, Traumatic Brain Injury, and Suicide Attempt History among Veterans Receiving Mental Health Services AN - 1429623270; 201307511 AB - History of posttraumatic stress disorder (PTSD) or traumatic brain injury (TBI) has been found to increase risk of suicidal behavior. The association between suicide attempt history among veterans with PTSD and/or TBI was explored. Cases (N = 81) and 2:1 matched controls (N = 160) were randomly selected from a Veterans Affairs Medical Center clinical database. PTSD history was associated with an increased risk for a suicide attempt (OR = 2.8; 95% CI: 1.5, 5.1). This increased risk was present for those with and without a history of TBI. Results support incorporating PTSD history when assessing suicide risk among veterans with and without TBI. Adapted from the source document. JF - Suicide and Life-Threatening Behavior AU - Brenner, Lisa A AU - Betthauser, Lisa M AU - Homaifar, Beeta Y AU - Villarreal, Edgar AU - Harwood, Jeri E.F. AU - Staves, Pamela J AU - Huggins, Joseph A Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 416 EP - 423 PB - John Wiley & Sons, Inc. VL - 41 IS - 4 SN - 0363-0234, 0363-0234 KW - Veterans KW - Risk KW - Injuries KW - Brain KW - Suicide KW - Medicine KW - Mental Health Services KW - Posttraumatic Stress Disorder KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1429623270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Suicide+and+Life-Threatening+Behavior&rft.atitle=Posttraumatic+Stress+Disorder%2C+Traumatic+Brain+Injury%2C+and+Suicide+Attempt+History+among+Veterans+Receiving+Mental+Health+Services&rft.au=Brenner%2C+Lisa+A%3BBetthauser%2C+Lisa+M%3BHomaifar%2C+Beeta+Y%3BVillarreal%2C+Edgar%3BHarwood%2C+Jeri+E.F.%3BStaves%2C+Pamela+J%3BHuggins%2C+Joseph+A&rft.aulast=Brenner&rft.aufirst=Lisa&rft.date=2011-08-01&rft.volume=41&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Suicide+and+Life-Threatening+Behavior&rft.issn=03630234&rft_id=info:doi/10.1111%2Fj.1943-278X.2011.00041.x LA - English DB - Social Services Abstracts N1 - Date revised - 2013-09-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SLBEDP N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Suicide; Risk; Veterans; Brain; Injuries; Medicine; Mental Health Services DO - http://dx.doi.org/10.1111/j.1943-278X.2011.00041.x ER - TY - JOUR T1 - Associations among experiential avoidance, couple adjustment, and interpersonal aggression in returning Iraqi war veterans and their partners. AN - 1023096348; 201217650 AB - Objective: The purpose of the present study was to examine the role of experiential avoidance (EA) in relationship adjustment, psychological aggression, and physical aggression among military couples. Method: The sample was composed of 49 male soldiers who recently returned from deployment to Iraq and their female partners. As part of a larger study, participants completed self-report measures of emotional avoidance (EA; Acceptance and Action Questionnaire-II), relationship adjustment (Dyadic Adjustment Scale), and conflict (Conflict Tactics Scale-2). Data from men and women were simultaneously modeled with the actor-partner interdependence model. Results: Men's EA was associated with decreases in relationship adjustment and increases in physical aggression perpetration and victimization. For women, relationship adjustment was not associated with EA, but greater EA among women was associated with decreased relationship adjustment for male partners. Associations among EA and psychological aggression were nonsignificant. Conclusions: These data provide evidence that EA may play a critical role in the relationships of couples following deployment and highlight the importance of targeting EA in couple therapy. [Copyright American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Reddy, Madhavi K AU - Meis, Laura A AU - Erbes, Christopher R AU - Polusny, Melissa A AU - Compton, Jill S AD - Minneapolis VA Medical Center Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 515 EP - 520 PB - American Psychological Association, Washington DC VL - 79 IS - 4 SN - 0022-006X, 0022-006X KW - Avoidance KW - Psychic assault KW - Women KW - Aggression KW - Adjustment KW - Deployment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023096348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=Associations+among+experiential+avoidance%2C+couple+adjustment%2C+and+interpersonal+aggression+in+returning+Iraqi+war+veterans+and+their+partners.&rft.au=Reddy%2C+Madhavi+K%3BMeis%2C+Laura+A%3BErbes%2C+Christopher+R%3BPolusny%2C+Melissa+A%3BCompton%2C+Jill+S&rft.aulast=Reddy&rft.aufirst=Madhavi&rft.date=2011-08-01&rft.volume=79&rft.issue=4&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2Fa0023929 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Adjustment; Aggression; Avoidance; Psychic assault; Women; Deployment DO - http://dx.doi.org/10.1037/a0023929 ER - TY - JOUR T1 - Couple adjustment and posttraumatic stress disorder symptoms in National Guard veterans of the Iraq war. AN - 1023026878; 201226029 AB - Relationship adjustment and posttraumatic stress disorder (PTSD) symptoms were assessed across two time points in a sample of 313 married or partnered National Guard soldiers recently returned from combat duty in Iraq. Structural equation modeling using a four-factor model for PTSD found the latent variable dysphoria (reflecting generalized distress including aspects of emotional numbing and arousal) had the strongest independent contribution to predicting relationship adjustment at Time 1 and indirectly predicted poorer relationship adjustment at Time 2. Exploratory analysis of gender differences (n = 33 women; n = 280 men) suggested a different pattern of relations between PTSD factors and relationship adjustment among female soldiers at Time 1, with a trend toward trauma specific avoidance being more highly related to relationship adjustment. Clinical and research implications are discussed. [Copyright The American Psychological Association.] JF - Journal of Family Psychology AU - Erbes, Christopher R AU - Meis, Laura A AU - Polusny, Melissa A AU - Compton, Jill S Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 479 EP - 487 PB - American Psychological Association, Washington DC VL - 25 IS - 4 SN - 0893-3200, 0893-3200 KW - Couples KW - Veterans KW - Symptoms KW - War KW - Military Personnel KW - Sex Differences KW - Posttraumatic Stress Disorder KW - Adjustment KW - Iraq KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023026878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Psychology&rft.atitle=Couple+adjustment+and+posttraumatic+stress+disorder+symptoms+in+National+Guard+veterans+of+the+Iraq+war.&rft.au=Erbes%2C+Christopher+R%3BMeis%2C+Laura+A%3BPolusny%2C+Melissa+A%3BCompton%2C+Jill+S&rft.aulast=Erbes&rft.aufirst=Christopher&rft.date=2011-08-01&rft.volume=25&rft.issue=4&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Psychology&rft.issn=08933200&rft_id=info:doi/10.1037%2Fa0024007 LA - English DB - Sociological Abstracts N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JFPSEV N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Adjustment; Sex Differences; Iraq; Military Personnel; War; Symptoms; Veterans; Couples DO - http://dx.doi.org/10.1037/a0024007 ER - TY - JOUR T1 - Effects of stimulus and recording parameters on the air conduction ocular vestibular evoked myogenic potential. AN - 914298553; pmid-21993052 AB - Vestibular evoked myogenic potentials (VEMPs) have been recorded from the sternocleidomastoid muscle (cervical VEMP or cVEMP) and more recently from the eye muscles (ocular VEMP or oVEMP) in response to air conduction and bone conduction stimuli. Both cVEMPs and oVEMPs are mediated by the otoliths and thereby provide diagnostic information that is complementary to videonystagmography and rotational chair tests. In contrast to the air conduction cVEMP, which originates from the saccule/inferior vestibular nerve, recent evidence suggests the possibility that the air conduction oVEMP may be mediated by the utricle/superior vestibular nerve. The oVEMP, therefore, may provide complementary diagnostic information relative to the cVEMP. There are relatively few studies, however, that have quantified the effects of stimulus and recording parameters on the air conduction oVEMP, and there is a paucity of normative data.To evaluate the effects of several stimulus and recording parameters on the air conduction oVEMP and to establish normative data for clinical use.A prospective repeated measures design was utilized.Forty-seven young adults with no history of neurologic disease, hearing loss, middle ear pathology, open or closed head injury, cervical injury, or audiovestibular disorder participated in the study.The effects of stimulus frequency, stimulus level, gaze elevation, and recording electrode location on the amplitude and latency of the oVEMP for monaural air conduction stimuli were assessed using repeated measures analyses of variance in an initial group of 17 participants. The optimal stimulus and recording parameters obtained in the initial group were used subsequently to obtain oVEMPs from 30 additional participants.The effects of stimulus frequency, stimulus level, gaze elevation, and electrode location on the response prevalence, amplitude, and latency of the oVEMP for monaural air conduction stimuli were significant. The maximum N1-P1 amplitude and response prevalence were obtained for contralateral oVEMPs using a 500 Hz tone burst presented at 125 dB peak SPL during upward gaze at an elevation of 30°.The optimal stimulus and recording parameters quantified in this study were used to establish normative data that may be useful for the clinical application of the air conduction oVEMP.American Academy of Audiology. JF - Journal of the American Academy of Audiology AU - Murnane, Owen D AU - Akin, Faith W AU - Kelly, Kip J AU - Byrd, Stephanie AD - James H. Quillen VA Medical Center, Mountain Home, TN, USA. owen.murnane@va.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 469 EP - 480 VL - 22 IS - 7 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - *Acoustic Stimulation: methods KW - Adolescent KW - Adult KW - *Auditory Perception: physiology KW - Female KW - Fixation, Ocular: physiology KW - Humans KW - Male KW - *Otolithic Membrane: physiology KW - Prospective Studies KW - Reaction Time: physiology KW - Reference Values KW - Saccule and Utricle: physiology KW - Sound Spectrography KW - *Vestibular Evoked Myogenic Potentials: physiology KW - Vestibular Nerve: physiology KW - Young Adult UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914298553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Effects+of+stimulus+and+recording+parameters+on+the+air+conduction+ocular+vestibular+evoked+myogenic+potential.&rft.au=Murnane%2C+Owen+D%3BAkin%2C+Faith+W%3BKelly%2C+Kip+J%3BByrd%2C+Stephanie&rft.aulast=Murnane&rft.aufirst=Owen&rft.date=2011-07-01&rft.volume=22&rft.issue=7&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-30 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - A comparison of gain for adults from generic hearing aid prescriptive methods: impacts on predicted loudness, frequency bandwidth, and speech intelligibility. AN - 914298551; pmid-21993050 AB - Prescriptive methods have been at the core of modern hearing aid fittings for the past several decades. Every decade or so, there have been revisions to existing methods and/or the emergence of new methods that become widely used. In 2001 Byrne et al provided a comparison of insertion gain for generic prescriptive methods available at that time.The purpose of this article was to compare National Acoustic Laboratories-Non-linear 1 (NAL-NL1), National Acoustic Laboratories-Non-linear 2 (NAL-NL2), Desired Sensation Level Multistage Input/Output (DSL m[i/o]), and Cambridge Method for Loudness Equalization 2-High-Frequency (CAMEQ2-HF) prescriptive methods for adults on the amplification characteristics of prescribed insertion gain and compression ratio. Following the differences observed in prescribed insertion gain among the four prescriptive methods, analyses of predicted specific loudness, overall loudness, and bandwidth of cochlear excitation and effective audibility as well as speech intelligibility of the international long-term average speech spectrum (ILTASS) at an average conversational input level were completed. These analyses allow for the discussion of similarities and differences among the present-day prescriptive methods.The impact of insertion gain differences among the methods is examined for seven hypothetical hearing loss configurations using models of loudness perception and speech intelligibility.Hearing loss configurations for adults of various types and degrees were selected, five of which represent sensorineural impairment and were used by Byrne et al; the other two hearing losses provide an example of mixed and conductive impairment.Prescribed insertion gain data were calculated in 1/3-octave frequency bands for each of the seven hearing losses from the software application of each prescriptive method over multiple input levels. The insertion gain data along with a diffuse field-to-eardrum transfer function were used to calculate output levels at the eardrums of the hypothetical listeners. Levels of hearing loss and output were then used in the Moore and Glasberg loudness model and the ANSI S3.5-1997 Speech Intelligibility Index model.NAL-NL2 and DSL m[i/o] provided comparable overall loudness of approximately 8 sones for the five sensorineural hearing losses for a 65 dB SPL ILTASS input. This loudness was notably less than that perceived by a normal-hearing person for the same input signal, 18.6 sones. NAL-NL2 and DSL m[i/o] also provided comparable predicted speech intelligibility in quiet and noise. CAMEQ2-HF provided a greater average loudness, similar to NAL-NL1, with more high-frequency bandwidth but no significant improvement to predicted speech intelligibility.Definite variation in prescribed insertion gain was present among the prescriptive methods. These differences when averaged across the hearing losses were, by and large, negligible with regard to predicted speech intelligibility at normal conversational speech levels. With regard to loudness, DSL m[i/o] and NAL-NL2 provided the least overall loudness, followed by CAMEQ2-HF and NAL-NL1 providing the most loudness. CAMEQ2-HF provided the most audibility at high frequencies; even so, the audibility became less effective for improving speech intelligibility as hearing loss severity increased.American Academy of Audiology. JF - Journal of the American Academy of Audiology AU - Johnson, Earl E AU - Dillon, Harvey AD - James H. Quillen VA Medical Center, Mountain Home, TN, USA. earl.johnson@va.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 441 EP - 459 VL - 22 IS - 7 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Audiometry, Pure-Tone KW - Equipment Design KW - *Hearing Aids KW - *Hearing Loss, Sensorineural: rehabilitation KW - Humans KW - *Loudness Perception KW - Perceptual Masking KW - *Pitch Perception KW - *Prescriptions KW - Software KW - Sound Spectrography KW - Speech Discrimination Tests KW - *Speech Perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914298551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=A+comparison+of+gain+for+adults+from+generic+hearing+aid+prescriptive+methods%3A+impacts+on+predicted+loudness%2C+frequency+bandwidth%2C+and+speech+intelligibility.&rft.au=Johnson%2C+Earl+E%3BDillon%2C+Harvey&rft.aulast=Johnson&rft.aufirst=Earl&rft.date=2011-07-01&rft.volume=22&rft.issue=7&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-30 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Development of the self-efficacy for tinnitus management questionnaire. AN - 914298550; pmid-21993049 AB - Self-efficacy refers to the beliefs (i.e., confidence) individuals have in their capabilities to perform skills needed to accomplish a specific goal or behavior. Research in the treatment of various health conditions such as chronic pain, balance disorders, and diabetes shows that self-efficacy beliefs play an important role in treatment outcomes and management of the condition. This article focuses on the application of self-efficacy to the management of tinnitus. The first step in formally incorporating self-efficacy in existing treatment regimens or developing a self-efficacy approach for tinnitus treatment is to have a valid and reliable measure available to assess the level of tinnitus self-efficacy.The objective of this study was to develop the Self-Efficacy for Tinnitus Management Questionnaire (SETMQ) and to obtain the psychometric properties of the questionnaire in a group of patients with tinnitus.Observational study.A total of 199 patients who were enrolled in the Tinnitus Clinic at the James H. Quillen Veterans Affairs Medical Center participated in the current study.The SETMQ was mailed to patients enrolled in the Tinnitus Clinic. The participants who completed one copy of the SETMQ were mailed a second copy to complete approximately 2 weeks later. An exploratory factor analysis was conducted to identify the most coherent subscale structure of the SETMQ. The internal consistency and test-retest reliability for each of the subscales and the questionnaire as a whole were assessed. The validity of the SETMQ also was evaluated by investigating the relations between the SETMQ and other clinical measures related to tinnitus.Five components emerged from the factor analysis that explained 75.8% of the variance related to the following areas: (1) routine tinnitus management, (2) emotional response to tinnitus, (3) internal thoughts and interaction with others, (4) tinnitus concepts, and (5) use of assistive devices. Four items failed to load on any factor and were discarded, resulting in 40 items on the final SETMQ. The internal consistency reliability of the overall questionnaire and for each subscale was good (Chronbach's α ranged from .74 to .98). Item-total correlations ranged from .47 to .86, indicating that each item on the SETMQ correlated at a moderate or marked level with the SETMQ aggregate score. Intraclass correlation coefficients were computed to determine the test-retest reliability of the SETMQ total scale and separately for each subscale, which were all above .80, indicating good test-retest reliability. Correlations among the SETMQ subscales and various tinnitus-related measures (e.g., Tinnitus Handicap Inventory, tinnitus loudness rating, tinnitus distress rating, etc.) were significant, albeit indicative of fair to good relations overall (range r = -.18 to -.53).The results of the current study suggest that the SETMQ is a valid and reliable measure that may be an insightful instrument for clinicians and investigators who are interested in assessing tinnitus self-efficacy. Incorporating self-efficacy principles into tinnitus management would provide clinicians with another formalized treatment option. A self-efficacy approach to treating tinnitus may result in better outcomes compared with approaches not focusing on self-efficacy principles.American Academy of Audiology. JF - Journal of the American Academy of Audiology AU - Smith, Sherri L AU - Fagelson, Marc AD - Research and Development Service, Department of Veterans Affairs, James H. Quillen Veterans Affairs Medical Center, Mountain Home, TN, USA. sheri.smith@va.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 424 EP - 440 VL - 22 IS - 7 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adaptation, Psychological KW - Adult KW - Aged KW - Aged, 80 and over KW - Audiometry, Pure-Tone: statistics & numerical data KW - Auditory Threshold KW - Awareness KW - Disability Evaluation KW - Female KW - Humans KW - Hyperacusis: diagnosis KW - Hyperacusis: psychology KW - Male KW - Middle Aged KW - Psychometrics: statistics & numerical data KW - *Questionnaires KW - Reproducibility of Results KW - *Self Efficacy KW - *Tinnitus: psychology KW - Tinnitus: therapy KW - *Veterans: psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914298550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Development+of+the+self-efficacy+for+tinnitus+management+questionnaire.&rft.au=Smith%2C+Sherri+L%3BFagelson%2C+Marc&rft.aulast=Smith&rft.aufirst=Sherri&rft.date=2011-07-01&rft.volume=22&rft.issue=7&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-30 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Clinical experience with the words-in-noise test on 3430 veterans: comparisons with pure-tone thresholds and word recognition in quiet. AN - 914298303; pmid-21993048 AB - Since the 1940s, measures of pure-tone sensitivity and speech recognition in quiet have been vital components of the audiologic evaluation. Although early investigators urged that speech recognition in noise also should be a component of the audiologic evaluation, only recently has this suggestion started to become a reality. This report focuses on the Words-in-Noise (WIN) Test, which evaluates word recognition in multitalker babble at seven signal-to-noise ratios and uses the 50% correct point (in dB SNR) calculated with the Spearman-Kärber equation as the primary metric. The WIN was developed and validated in a series of 12 laboratory studies. The current study examined the effectiveness of the WIN materials for measuring the word-recognition performance of patients in a typical clinical setting.To examine the relations among three audiometric measures including pure-tone thresholds, word-recognition performances in quiet, and word-recognition performances in multitalker babble for veterans seeking remediation for their hearing loss.Retrospective, descriptive. Study Sample: The participants were 3430 veterans who for the most part were evaluated consecutively in the Audiology Clinic at the VA Medical Center, Mountain Home, Tennessee. The mean age was 62.3 yr (SD = 12.8 yr).The data were collected in the course of a 60 min routine audiologic evaluation. A history, otoscopy, and aural-acoustic immittance measures also were included in the clinic protocol but were not evaluated in this report.Overall, the 1000-8000 Hz thresholds were significantly lower (better) in the right ear (RE) than in the left ear (LE). There was a direct relation between age and the pure-tone thresholds, with greater change across age in the high frequencies than in the low frequencies. Notched audiograms at 4000 Hz were observed in at least one ear in 41% of the participants with more unilateral than bilateral notches. Normal pure-tone thresholds (≤20 dB HL) were obtained from 6% of the participants. Maximum performance on the Northwestern University Auditory Test No. 6 (NU-6) in quiet was ≥90% correct by 50% of the participants, with an additional 20% performing at ≥80% correct; the RE performed 1-3% better than the LE. Of the 3291 who completed the WIN on both ears, only 7% exhibited normal performance (50% correct point of ≤6 dB SNR). Overall, WIN performance was significantly better in the RE (mean = 13.3 dB SNR) than in the LE (mean = 13.8 dB SNR). Recognition performance on both the NU-6 and the WIN decreased as a function of both pure-tone hearing loss and age. There was a stronger relation between the high-frequency pure-tone average (1000, 2000, and 4000 Hz) and the WIN than between the pure-tone average (500, 1000, and 2000 Hz) and the WIN.The results on the WIN from both the previous laboratory studies and the current clinical study indicate that the WIN is an appropriate clinic instrument to assess word-recognition performance in background noise. Recognition performance on a speech-in-quiet task does not predict performance on a speech-in-noise task, as the two tasks reflect different domains of auditory function. Experience with the WIN indicates that word-in-noise tasks should be considered the "stress test" for auditory function.American Academy of Audiology. JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AD - James H. Quillen VA Medical Center, Mountain Home, TN, USA. richard.wilson2@va.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 405 EP - 423 VL - 22 IS - 7 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - *Audiometry, Pure-Tone: statistics & numerical data KW - *Auditory Threshold KW - Female KW - Hearing Loss, High-Frequency: diagnosis KW - Hearing Loss, Unilateral: diagnosis KW - Hospitals, Veterans KW - Humans KW - Male KW - Middle Aged KW - *Noise KW - *Perceptual Masking KW - Presbycusis: diagnosis KW - Psychometrics KW - Reference Values KW - Retrospective Studies KW - *Speech Discrimination Tests: statistics & numerical data KW - *Speech Reception Threshold Test: statistics & numerical data KW - Statistics as Topic KW - Tennessee KW - *Veterans KW - Young Adult UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914298303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Clinical+experience+with+the+words-in-noise+test+on+3430+veterans%3A+comparisons+with+pure-tone+thresholds+and+word+recognition+in+quiet.&rft.au=Wilson%2C+Richard+H&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2011-07-01&rft.volume=22&rft.issue=7&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-30 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Temporal processing in low-frequency channels: effects of age and hearing loss in middle-aged listeners. AN - 914298302; pmid-21993047 AB - Hearing loss and age interfere with the auditory system's ability to process temporal changes in the acoustic signal. A key unresolved question is whether high-frequency sensorineural hearing loss (HFSNHL) affects temporal processing in the low-frequency region where hearing loss is minimal or nonexistent. A second unresolved question is whether changes in hearing occur in middle-aged subjects in the absence of HFSNHL.The purpose of this study was twofold: (1) to examine the influence of HFSNHL and aging on the auditory temporal processing abilities of low-frequency auditory channels with normal hearing sensitivity and (2) to examine the relations among gap detection measures, self-assessment reports of understanding speech, and functional measures of speech perception in middle-aged individuals with and without HFSNHL.The subject groups were matched for either age (middle age) or pure-tone sensitivity (with or without hearing loss) to study the effects of age and HFSNHL on behavioral and functional measures of temporal processing and word recognition performance. These effects were analyzed by individual repeated-measures analyses of variance. Post hoc analyses were performed for each significant main effect and interaction. The relationships among the measures were analyzed with Pearson correlations.Eleven normal-hearing young adults (YNH), eight normal-hearing middle-aged adults (MANH), and nine middle-aged adults with HFSNHL were recruited for this study. Normal hearing sensitivity was defined as pure-tone thresholds ≤25 dB HL for octave frequencies from 250 to 8000 Hz. HFSNHL was defined as pure-tone thresholds ≤25 dB HL from 250 to 2000 Hz and ≥35 dB HL from 3000 to 8000 Hz.Gap detection thresholds (GDTs) were measured under within-channel and between-channel conditions with the stimulus spectrum limited to regions of normal hearing sensitivity for the HFSNHL group (i.e., <2000 Hz). Self-perceived hearing problems were measured by a questionnaire (Abbreviated Profile of Hearing Aid Benefit), and word recognition performance was assessed under four conditions: quiet and babble, with and without low-pass filtering (cutoff frequency = 2000 Hz).The effects of HFSNHL and age were found for gap detection, self-perceived hearing problems, and word recognition in noise. The presence of HFSNHL significantly increased GDTs for stimuli presented in regions of normal pure-tone sensitivity. In addition, middle-aged subjects with normal hearing sensitivity reported significantly more problems hearing in background noise than the young normal-hearing subjects. Significant relationships between self-report measures of hearing ability in background noise and word recognition in babble were found.The conclusions from the present study are twofold: (1) HFSNHL may have an off-channel impact on auditory temporal processing, and (2) presenescent changes in the auditory system of MANH subjects increased self-perceived problems hearing in background noise and decreased functional performance in background noise compared with YNH subjects.American Academy of Audiology. JF - Journal of the American Academy of Audiology AU - Leigh-Paffenroth, Elizabeth D AU - Elangovan, Saravanan AD - James H. Quillen VA Medical Center, Mountain Home, TN, USA. elizabeth.leigh@med.va.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 393 EP - 404 VL - 22 IS - 7 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Auditory Threshold KW - Female KW - *Hearing Loss, High-Frequency: diagnosis KW - Humans KW - Male KW - Middle Aged KW - Perceptual Masking KW - *Pitch Discrimination KW - *Pitch Perception KW - *Presbycusis: diagnosis KW - Sound Spectrography KW - Speech Perception KW - Speech Reception Threshold Test KW - *Time Perception KW - Young Adult UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914298302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Temporal+processing+in+low-frequency+channels%3A+effects+of+age+and+hearing+loss+in+middle-aged+listeners.&rft.au=Leigh-Paffenroth%2C+Elizabeth+D%3BElangovan%2C+Saravanan&rft.aulast=Leigh-Paffenroth&rft.aufirst=Elizabeth&rft.date=2011-07-01&rft.volume=22&rft.issue=7&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-30 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Sexual Revictimization and Adjustment in College Men AN - 902096588; 201118715 AB - Child sexual abuse (CSA) and adult sexual assault (ASA) occur at alarming rates in the United States and are associated with a number of adult psychological adjustment problems. Moreover, having a history of CSA may increase risk for sexual victimization in adulthood (revictimization). A number of studies explore the issues of CSA, ASA, revictimization, and adjustment in women, but far fewer studies investigate these issues in men. This study explored the phenomenon of sexual revictimization and related adjustment difficulties in 1,002 male college students who completed the Life Experiences Questionnaire, an expanded version of the Sexual Experiences Survey, and the Symptom Checklist-90 -- Revised. Results indicated that male CSA survivors are more likely than nonvictims to experience ASA and that sexual victimization and revictimization are related to increased adult adjustment difficulties in the forms of posttraumatic stress, hostility, depression, and general distress. Research and clinical implications are discussed, such as the need to assess male psychotherapy clients for sexual victimization and revictimization histories and the need for research on the mechanisms resulting in psychological adjustment difficulties in male survivors of sexual victimization and revictimization. [Copyright The American Psychological Association.] JF - Psychology of Men & Masculinity AU - Aosved, Allison C AU - Long, Patricia J AU - Voller, Emily K AD - Department of Veterans Affairs, Pacific Islands Health Care System, Honolulu Allison.aosved2@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 285 EP - 296 PB - American Psychological Association, Washington DC VL - 12 IS - 3 SN - 1524-9220, 1524-9220 KW - men rape sexual abuse revictimization adjustment KW - Men KW - Revictimization KW - Sexual violence KW - Survivors KW - Adjustment KW - Victimization KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902096588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Men+%26+Masculinity&rft.atitle=Sexual+Revictimization+and+Adjustment+in+College+Men&rft.au=Aosved%2C+Allison+C%3BLong%2C+Patricia+J%3BVoller%2C+Emily+K&rft.aulast=Aosved&rft.aufirst=Allison&rft.date=2011-07-01&rft.volume=12&rft.issue=3&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Men+%26+Masculinity&rft.issn=15249220&rft_id=info:doi/10.1037%2Fa0020828 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Revictimization; Adjustment; Men; Sexual violence; Victimization; Survivors DO - http://dx.doi.org/10.1037/a0020828 ER - TY - JOUR T1 - Association of change in depression and anxiety symptoms with functional outcomes in pulmonary rehabilitation patients AN - 896227869; 201117937 AB - Objective Pulmonary rehabilitation (PR) has emerged over the last decade as an essential component of an integrated approach to managing patients with chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD). We sought to examine how depression and anxiety symptom changes relate to disease-specific quality of life outcomes following PR. Methods We performed a cohort study of 81 patients with COPD who completed PR at a Veterans Administration Medical Center. Pulmonary rehabilitation consisted of supervised exercise training and education twice weekly for 8 weeks. Beck Depression and Anxiety Inventories (BDI and BAI) assessed symptom burden at baseline and completion of PR. We measured change in disease-specific quality of life using the dyspnea, mastery, emotion and fatigue domains of the Chronic Respiratory Questionnaire Self-Reported (CRQ-SR) from baseline to completion of PR. Results Participants were 69.8+/-9.1 years old and all male. Forced expiratory volume in 1 s (FEV1) was 1.23+/-0.39 L. The CRQ-SR scores improved significantly: dyspnea (P<.0001), mastery (P=.015) and fatigue (P=.017). The BDI scores improved significantly (13.1+/-10.5 to 10.8+/-9.9, P=.003; BAI: 13.1+/-10.1 to 12.1+/-11.7). Multivariate regression models controlling for age, FEV1, depression treatment and anxiety treatment showed that improvement in depressive symptoms were associated with improvement in fatigue (P=.003), emotion (P=.003) and mastery (P=.01). Anxiety symptom change was not significantly associated with change in disease-specific quality of life domains. Conclusion Addressing anxiety symptoms in PR patients may be indicated because disease-specific quality of life improvement appears to be associated with mood. [Copyright Elsevier Inc.] JF - Journal of Psychosomatic Research AU - Pirraglia, Paul A AU - Casserly, Brian AU - Velasco, Robert AU - Borgia, Matthew L AU - Nici, Linda AD - Primary Care Service and the Systems Outcomes and Quality in Chronic disease and Rehabilitation (SOQCR) Research Enhancement Award Program, Providence Veterans Affairs Medical Center, Providence, RI, USA paul.pirraglia@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 45 EP - 49 PB - Elsevier Science Inc. VL - 71 IS - 1 SN - 0022-3999, 0022-3999 KW - Pulmonary disease Chronic obstructive Rehabilitation Depression Anxiety KW - Symptoms KW - Fatigue KW - Rehabilitation KW - Chronic obstructive pulmonary disease KW - Quality of life KW - Anxiety-Depression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896227869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychosomatic+Research&rft.atitle=Association+of+change+in+depression+and+anxiety+symptoms+with+functional+outcomes+in+pulmonary+rehabilitation+patients&rft.au=Pirraglia%2C+Paul+A%3BCasserly%2C+Brian%3BVelasco%2C+Robert%3BBorgia%2C+Matthew+L%3BNici%2C+Linda&rft.aulast=Pirraglia&rft.aufirst=Paul&rft.date=2011-07-01&rft.volume=71&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychosomatic+Research&rft.issn=00223999&rft_id=info:doi/10.1016%2Fj.jpsychores.2011.01.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - CODEN - JPCRAT N1 - SubjectsTermNotLitGenreText - Anxiety-Depression; Symptoms; Quality of life; Chronic obstructive pulmonary disease; Fatigue; Rehabilitation DO - http://dx.doi.org/10.1016/j.jpsychores.2011.01.002 ER - TY - JOUR T1 - Prevalence, correlates, and symptom profiles of depression among men with a history of military service AN - 883026526; 15165236 AB - Purpose: The purpose of this study was to examine the prevalence, correlates, and symptom profiles of depressive disorders in men with a history of military service. Methods: Data were obtained from the 2006 Behavioral Risk Factor Surveillance System survey. Multivariable logistic regressions were used to identify correlates of lifetime and current depression. Regularly occurring symptom profiles were identified via cluster analysis. Results: Prevalence of lifetime and current depression was similar in men with and without a history of military service. Younger age was positively, and black minority status, being in a relationship and self-reported good health were negatively associated with a lifetime diagnosis of depression. Other minority status (non-Hispanic, non-black) was positively, and older age, some college, being in a relationship, and self-reported good health were negatively associated with current depression. A cluster of younger men who experience significant depressive symptoms but may not report depressed mood or anhedonia was identified. Conclusions: Depression is as prevalent in men with a history of military service as it is in men without a history. Research should focus on subpopulations of men with a history of military service in which depression may be more prevalent or burdensome. Younger men with significant depressive symptoms may be missed by standard depression screens and still be at elevated risk for negative outcomes associated with depression. JF - Social Psychiatry and Psychiatric Epidemiology AU - Britton, Peter C AU - Bossarte, Robert M AU - Lu, Naiji AU - He, Hua AU - Currier, Glenn W AU - Crilly, John AU - Richardson, Tom AU - Tu, Xin AU - Knox, Kerry L AD - Center of Excellence, Department of Veterans Affairs, Canandaigua Medical Center, 400 Fort Hill Avenue, Canandaigua, NY , 14424, USA, peter.britton@va.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 607 EP - 614 PB - Springer Science+Business Media, P.O. Box 2485 Secaucus NJ 07096-2485 United States VL - 46 IS - 7 SN - 0933-7954, 0933-7954 KW - Risk Abstracts KW - Historical account KW - Age KW - males KW - depression KW - subpopulations KW - Risk factors KW - Military KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883026526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Psychiatry+and+Psychiatric+Epidemiology&rft.atitle=Prevalence%2C+correlates%2C+and+symptom+profiles+of+depression+among+men+with+a+history+of+military+service&rft.au=Britton%2C+Peter+C%3BBossarte%2C+Robert+M%3BLu%2C+Naiji%3BHe%2C+Hua%3BCurrier%2C+Glenn+W%3BCrilly%2C+John%3BRichardson%2C+Tom%3BTu%2C+Xin%3BKnox%2C+Kerry+L&rft.aulast=Britton&rft.aufirst=Peter&rft.date=2011-07-01&rft.volume=46&rft.issue=7&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Social+Psychiatry+and+Psychiatric+Epidemiology&rft.issn=09337954&rft_id=info:doi/10.1007%2Fs00127-010-0226-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Historical account; Age; subpopulations; Risk factors; males; Military; depression DO - http://dx.doi.org/10.1007/s00127-010-0226-y ER - TY - JOUR T1 - A Flexible Approach to Studying Post-Transcriptional Gene Regulation in Stably Transfected Mammalian Cells AN - 876249546; 14992524 AB - The study of post-transcriptional regulation is constrained by the technical limitations associated with both transient and stable transfection of chimeric reporter plasmids examining the activity of 3'-UTR cis-acting elements. We report the adaptation of a commercially available system that enables consistent stable integration of chimeric reporter cDNA into a single genomic site in which transcription is induced by tetracycline. Using this system, we demonstrate the tight control afforded by this system and its suitability in mapping the regulatory function of defined cis-acting elements in the human TNF 3'-UTR, as well as the distinct effects of serum starvation on transiently transfected and stably integrated chimeric reporter genes. JF - Molecular Biotechnology AU - Nichols, Ralph C AU - Botson, John AU - Wang, Xiao Wei AU - Hamilton, BJoNell AU - Collins, Jane E AU - Uribe, Victoria AU - Brooks, Seth A AU - Zan, Moe AU - Rigby, William FC AD - Veterans Administration Research Service, Veterans Affairs Medical Center, Mailstop 151, 215 North Main Street, White River Junction, VT, 05009-0001, USA Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 210 EP - 217 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 48 IS - 3 SN - 1073-6085, 1073-6085 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - 3' Untranslated regions KW - W 30905:Medical Applications KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876249546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Biotechnology&rft.atitle=A+Flexible+Approach+to+Studying+Post-Transcriptional+Gene+Regulation+in+Stably+Transfected+Mammalian+Cells&rft.au=Nichols%2C+Ralph+C%3BBotson%2C+John%3BWang%2C+Xiao+Wei%3BHamilton%2C+BJoNell%3BCollins%2C+Jane+E%3BUribe%2C+Victoria%3BBrooks%2C+Seth+A%3BZan%2C+Moe%3BRigby%2C+William+FC&rft.aulast=Nichols&rft.aufirst=Ralph&rft.date=2011-07-01&rft.volume=48&rft.issue=3&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Molecular+Biotechnology&rft.issn=10736085&rft_id=info:doi/10.1007%2Fs12033-010-9360-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-04-03 N1 - SubjectsTermNotLitGenreText - 3' Untranslated regions DO - http://dx.doi.org/10.1007/s12033-010-9360-8 ER - TY - JOUR T1 - Systematic review: the role of bile acids in the pathogenesis of gastro-oesophageal reflux disease and related neoplasia. AN - 872440949; 21615439 AB - Factors other than acid may play a role in gastro-oesophageal reflux disease (GERD) and its complications. To assessed the role of bile acids in the pathogenesis of GERD, Barrett's oesophagus and Barrett's-related neoplasia. We conducted a systematic review of computerised bibliographic databases for original articles involving humans or human oesophageal tissue or cells that assessed exposure to or manipulation of bile acids. Outcomes assessed included GERD symptoms; gross oesophageal injury; Barrett's oesophagus and related neoplasia; and intermediate markers of inflammation, proliferation or neoplasia. Eighty-three original articles were included. In in vivo studies, bile acids concentrations were higher in the oesophageal aspirates of patients with GERD than controls, and bile acids infusions triggered GERD symptoms, especially in high concentrations or in combination with acid. In ex vivo/in vitro studies, bile acids stimulated squamous oesophageal cells and Barrett's epithelial cells to produce inflammatory mediators (e.g., IL-8 and COX-2) and caused oxidative stress, DNA damage and apoptosis. They also induced squamous cells to change their gene expression pattern to resemble intestinal-type cells and caused Barrett's cells to increase expression of intestinal-type genes. In aggregate, these studies suggest that bile acids may contribute to the pathogenesis of symptoms, oesophagitis and Barrett's metaplasia with related carcinogenesis in patients with GERD. However, all study results are not uniform and substantial differences in study parameters may explain at least some of this variation. © 2011 Blackwell Publishing Ltd. JF - Alimentary pharmacology & therapeutics AU - McQuaid, K R AU - Laine, L AU - Fennerty, M B AU - Souza, R AU - Spechler, S J AD - Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, CA 94121, USA. kenneth.mcquaid@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 146 EP - 165 VL - 34 IS - 2 KW - Bile Acids and Salts KW - 0 KW - Index Medicus KW - Hydrogen-Ion Concentration KW - Humans KW - Gastric Emptying -- physiology KW - Gastroesophageal Reflux -- etiology KW - Bile Acids and Salts -- physiology KW - Barrett Esophagus -- etiology KW - Esophageal Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872440949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alimentary+pharmacology+%26+therapeutics&rft.atitle=Systematic+review%3A+the+role+of+bile+acids+in+the+pathogenesis+of+gastro-oesophageal+reflux+disease+and+related+neoplasia.&rft.au=McQuaid%2C+K+R%3BLaine%2C+L%3BFennerty%2C+M+B%3BSouza%2C+R%3BSpechler%2C+S+J&rft.aulast=McQuaid&rft.aufirst=K&rft.date=2011-07-01&rft.volume=34&rft.issue=2&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=Alimentary+pharmacology+%26+therapeutics&rft.issn=1365-2036&rft_id=info:doi/10.1111%2Fj.1365-2036.2011.04709.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-07 N1 - Date created - 2011-06-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Nat Rev Gastroenterol Hepatol. 2011 Aug;8(8):419 [21818141] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2036.2011.04709.x ER - TY - JOUR T1 - Restrictive Emotionality, BIS, BAS, and Psychological Help-Seeking Behavior AN - 1823508435; 201120907 AB - This study examined the relationships among gender role conflict, attitudes toward seeking psychotherapy, and behavioral inhibition system (BIS) and behavioral activation system (BAS) sensitivity. Specifically, the present research tested the hypothesis that BIS sensitivity partially mediates the effects of two aspects of gender role conflict, restrictive emotionality, and restrictive affectionate behavior between men on attitudes toward psychotherapy. To achieve this goal, 285 male college students completed measures of gender role conflict, attitudes toward psychotherapy, and BIS and BAS sensitivity. Structural equation modeling (SEM) was used to test the hypothesized model against several alternative models. Contrary to expectations, no support was found for the hypothesis that BIS partially mediates the effects of restrictive emotionality and restrictive affectionate behavior between men on attitudes toward psychotherapy. However, restrictive emotionality was found to predict both BIS and attitudes toward psychotherapy. Additionally, a dimension of BAS sensitivity, BAS Drive, was also found to uniquely predict attitudes toward psychotherapy. In contrast, neither BIS nor restrictive affectionate behavior between men was significantly associated with attitudes toward psychotherapy in the SEM models. Taken together, these findings suggest that restrictive emotionality and BAS Drive are the dimensions of gender role conflict and motivational disposition most strongly associated with attitudes toward psychotherapy. [Copyright The American Psychological Association.] JF - Psychology of Men & Masculinity AU - Tsan, Jack Y AU - Day, Susan X AU - Schwartz, Jonathan P AU - Kimbrel, Nathan A AD - VISN 17 Center of Excellence for Research on Returning War Veterans, Department of Veterans Affairs in Waco, Texas jack.tsan@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 260 EP - 274 PB - American Psychological Association, Washington DC VL - 12 IS - 3 SN - 1524-9220, 1524-9220 KW - gender role conflict help seeking behavior motivation behavioral inhibition attitudes toward psychotherapy KW - Sensitivity KW - Attitudes KW - Psychotherapy KW - Behavioural approaches KW - Inhibition KW - Emotionality KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1823508435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Men+%26+Masculinity&rft.atitle=Restrictive+Emotionality%2C+BIS%2C+BAS%2C+and+Psychological+Help-Seeking+Behavior&rft.au=Tsan%2C+Jack+Y%3BDay%2C+Susan+X%3BSchwartz%2C+Jonathan+P%3BKimbrel%2C+Nathan+A&rft.aulast=Tsan&rft.aufirst=Jack&rft.date=2011-07-01&rft.volume=12&rft.issue=3&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Men+%26+Masculinity&rft.issn=15249220&rft_id=info:doi/10.1037%2Fa0021636 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Attitudes; Psychotherapy; Behavioural approaches; Inhibition; Emotionality; Sensitivity DO - http://dx.doi.org/10.1037/a0021636 ER - TY - JOUR T1 - Substance use disorders in Iraq and Afghanistan veterans in VA healthcare, 2001-2010: Implications for screening, diagnosis and treatment AN - 1761653841; 201118174 AB - The prevalence and correlates of alcohol use disorder (AUD) and drug use disorder (DUD) diagnoses in Iraq and Afghanistan veterans who are new users of Department of Veterans Affairs (VA) healthcare nationwide has not been evaluated. Methods: VA administrative data were used in retrospective cross-sectional descriptive and multivariable analyses to determine the prevalence and independent correlates of AUD and DUD in 456,502 Iraq and Afghanistan veterans who were first-time users of VA healthcare between October 15, 2001 and September 30, 2009 and followed through January 1, 2010. Results: Over 11% received substance use disorder diagnoses: AUD, DUD or both; 10% received AUD diagnoses, 5% received DUD diagnoses and 3% received both. Male sex, age 25 years, being never married or divorced, and proxies for greater combat exposure were independently associated with AUD and DUD diagnoses. Of those with AUD, DUD or both diagnoses, 55-75% also received PTSD or depression diagnoses. AUD, DUD or both diagnoses were 3-4.5 times more likely in veterans with PTSD and depression (p 0.001). Conclusions: Post-deployment AUD and DUD diagnoses were more prevalent in subgroups of Iraq and Afghanistan veterans and were highly comorbid with PTSD and depression. Stigma and lack of universal screening may have reduced the number of DUD diagnoses reported. There is a need for improved screening and diagnosis of substance use disorders and increased availability of integrated treatments that simultaneously address AUD and DUD in the context of PTSD and other deployment-related mental health disorders. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Seal, Karen H AU - Cohen, Greg AU - Waldrop, Angela AU - Cohen, Beth E AU - Maguen, Shira AU - Ren, Li AD - University of California, San Francisco and San Francisco Veterans Affairs Medical Center, 4150 Clement St., San Francisco, CA 94121, United States Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 93 EP - 101 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 116 IS - 1-3 SN - 0376-8716, 0376-8716 KW - Alcohol use disorders Drug use disorders Posttraumatic stress disorder Comorbidity Veterans KW - Veterans KW - Posttraumatic stress disorder KW - Health care KW - Substance abuse disorders KW - Afghanistan KW - Iraq KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761653841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Substance+use+disorders+in+Iraq+and+Afghanistan+veterans+in+VA+healthcare%2C+2001-2010%3A+Implications+for+screening%2C+diagnosis+and+treatment&rft.au=Seal%2C+Karen+H%3BCohen%2C+Greg%3BWaldrop%2C+Angela%3BCohen%2C+Beth+E%3BMaguen%2C+Shira%3BRen%2C+Li&rft.aulast=Seal&rft.aufirst=Karen&rft.date=2011-07-01&rft.volume=116&rft.issue=1-3&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2010.11.027 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Veterans; Afghanistan; Posttraumatic stress disorder; Iraq; Substance abuse disorders; Health care DO - http://dx.doi.org/10.1016/j.drugalcdep.2010.11.027 ER - TY - JOUR T1 - Mental Illness: Is there an Association With Cancer Screening Among Women Veterans? AN - 1038112771; 201223840 AB - Purpose: Mental illness may be a barrier to achieving timely and appropriate cancer screening. We evaluated the association of mental illness with receipt of and adherence to breast, cervical, and colorectal cancer screening among women Veterans. Methods: The study population included all female Veterans ages 50 to 65 who obtained care at the New Mexico VA Health Care System continuously from fiscal years 2004 to 2006 (n = 606). Measures were odds ratios (OR) for receipt of any cancer screening, and adherence to recommended cancer screening frequency, adjusted for age, insurance, service connection, and primary care and women's clinic visits. Results: Overall, 53% of the women had a mental health diagnosis (MHD). Women with an MHD were less likely to adhere to recommended breast cancer screening than women without MHD: unadjusted OR (95% CI): 0.73 (0.54-0.98; p < .05), adjusted OR (aOR) (95% CI) 0.60 (0.44-0.82; p < .01). Women with an MHD were as likely as women without MHD to receive any breast, cervical, and colon cancer screening: Respective aORs (95% CI): 0.79 (0.50-1.25); 1.71 (0.91-3.21); and 0.85 (0.56-1.28). Conclusion: Women with a mental illness are at risk for not adhering to recommended routine breast cancer screening, and may require more intensive efforts to achieve optimal rates of recommended breast cancer screening. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Yee, Ellen F.T. AU - White, Robert AU - Lee, Sang-Joon AU - Washington, Donna L AU - Yano, Elizabeth M AU - Murata, Glen AU - Handanos, Christine AU - Hoffman, Richard M AD - New Mexico VA Health Care 1501 San Pedro Drive SE (MC 111), Albuquerque, NM 87108 Ellen.yee2@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - S195 EP - S202 PB - Elsevier Science, New York NY VL - 21 IS - supp 4 SN - 1049-3867, 1049-3867 KW - Veterans KW - Screening KW - Mental illness KW - Women KW - Breast cancer KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038112771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Mental+Illness%3A+Is+there+an+Association+With+Cancer+Screening+Among+Women+Veterans%3F&rft.au=Yee%2C+Ellen+F.T.%3BWhite%2C+Robert%3BLee%2C+Sang-Joon%3BWashington%2C+Donna+L%3BYano%2C+Elizabeth+M%3BMurata%2C+Glen%3BHandanos%2C+Christine%3BHoffman%2C+Richard+M&rft.aulast=Yee&rft.aufirst=Ellen&rft.date=2011-07-01&rft.volume=21&rft.issue=supp+4&rft.spage=S195&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.027 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Women; Screening; Cancer; Mental illness; Veterans; Breast cancer DO - http://dx.doi.org/10.1016/j.whi.2011.04.027 ER - TY - JOUR T1 - Health and Health Care of Women Veterans and Women in the Military: Research Informing Evidence-Based Practice and Policy AN - 1038112761; 201223837 AB - Introduces a special journal issue focusing on health services research findings about women veterans and women in the military, framed in the context of informing evidence-based practice and policy. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Yano, Elizabeth M AU - Frayne, Susan M AD - VA Greater Los Angeles HSR&D Center of Excellence, 16111 Plummer Street (Mailcode 152), Sepulveda, CA 91343 Phone: +818-895-9449, Fax: +818-895-5838 elizabeth.yano@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - S64 EP - S66 PB - Elsevier Science, New York NY VL - 21 IS - supp 4 SN - 1049-3867, 1049-3867 KW - Veterans KW - Health care KW - Women KW - Women's issues KW - Health services KW - Evidence based medicine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038112761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Health+and+Health+Care+of+Women+Veterans+and+Women+in+the+Military%3A+Research+Informing+Evidence-Based+Practice+and+Policy&rft.au=Yano%2C+Elizabeth+M%3BFrayne%2C+Susan+M&rft.aulast=Yano&rft.aufirst=Elizabeth&rft.date=2011-07-01&rft.volume=21&rft.issue=supp+4&rft.spage=S64&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.030 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Women; Veterans; Evidence based medicine; Women's issues; Health services; Health care DO - http://dx.doi.org/10.1016/j.whi.2011.04.030 ER - TY - JOUR T1 - Using Research to Transform Care for Women Veterans: Advancing the Research Agenda and Enhancing Research-Clinical Partnerships AN - 1038112759; 201223836 AB - The purpose of this paper is to report on the outcomes of the 2010 VA Women's Health Services Research Conference, which brought together investigators interested in pursuing research on women veterans and women in the military with leaders in women's health care delivery and policy within and outside the VA, to significantly advance the state and future direction of VA women's health research and its potential impacts on practice and policy. Building on priorities assembled in the previous VA research agenda (2004) and the research conducted in the intervening six years, we used an array of approaches to foster research-clinical partnerships that integrated the state-of-the-science with the informational and strategic needs of senior policy and practice leaders. With demonstrated leadership commitment and support, broad field-based participation, strong interagency collaboration and a push to accelerate the move from observational to interventional and implementation research, the Conference provided a vital venue for establishing the foundation for a new research agenda. In this paper, we provide the historical evolution of the emergence of women veterans' health services research and an overview of the research in the intervening years since the first VA women's health research agenda. We then present the resulting VA Women's Health Research Agenda priorities and supporting activities designed to transform care for women veterans in six broad areas of study, including access to care and rural health; primary care and prevention; mental health; post deployment health; complex chronic conditions, aging and long-term care; and reproductive health. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Yano, Elizabeth M AU - Bastain, Lori A AU - Bean-Mayberry, Bevanne AU - Eisen, Seth AU - Frayne, Susan AU - Hayes, Patricia AU - Klap, Ruth AU - Lipson, Linda AU - Mattocks, Kristin AU - McGlynn, Geraldine AU - Sadler, Anne AU - Schnurr, Paula AU - Washington, Donna L AD - MSPH, VA Greater Los Angeles HSR&D Center of Excellence, 16111 Plummer Street (Mailcode 152), Sepulveda, CA 91343 Phone: +818-895-9449, Fax: +818-895-5838 elizabeth.yano@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - S73 EP - S83 PB - Elsevier Science, New York NY VL - 21 IS - supp 4 SN - 1049-3867, 1049-3867 KW - Veterans KW - Medical research KW - Women KW - Women's issues KW - Partnerships KW - Health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038112759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Using+Research+to+Transform+Care+for+Women+Veterans%3A+Advancing+the+Research+Agenda+and+Enhancing+Research-Clinical+Partnerships&rft.au=Yano%2C+Elizabeth+M%3BBastain%2C+Lori+A%3BBean-Mayberry%2C+Bevanne%3BEisen%2C+Seth%3BFrayne%2C+Susan%3BHayes%2C+Patricia%3BKlap%2C+Ruth%3BLipson%2C+Linda%3BMattocks%2C+Kristin%3BMcGlynn%2C+Geraldine%3BSadler%2C+Anne%3BSchnurr%2C+Paula%3BWashington%2C+Donna+L&rft.aulast=Yano&rft.aufirst=Elizabeth&rft.date=2011-07-01&rft.volume=21&rft.issue=supp+4&rft.spage=S73&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Women; Medical research; Women's issues; Health; Veterans; Partnerships DO - http://dx.doi.org/10.1016/j.whi.2011.04.002 ER - TY - JOUR T1 - A Five-Step Guide for Moving from Observational Studies to Interventional Research for Women Veterans AN - 1038112246; 201223396 AB - This paper is designed as a primer to accelerate the development of more intervention studies among women veterans. It advocates a five-step method by which researchers can move from observational findings to developing interventional research. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Rohrer, Lesley D AU - Gierisch, Jennifer M AU - Fish, Laura J AU - Blakeney, Jill K AU - Bastian, Lori A AD - MPH, Durham Veterans Affairs Medical Center, 508 Fulton Street (152), Durham, NC 27705 Phone: +919-286-0411, ext 4063, Fax: +919-416-5836 lesley.rohrer@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - S98 EP - S102 PB - Elsevier Science, New York NY VL - 21 IS - supp 4 SN - 1049-3867, 1049-3867 KW - Observational research KW - Veterans KW - Women KW - Advocacy services KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038112246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=A+Five-Step+Guide+for+Moving+from+Observational+Studies+to+Interventional+Research+for+Women+Veterans&rft.au=Rohrer%2C+Lesley+D%3BGierisch%2C+Jennifer+M%3BFish%2C+Laura+J%3BBlakeney%2C+Jill+K%3BBastian%2C+Lori+A&rft.aulast=Rohrer&rft.aufirst=Lesley&rft.date=2011-07-01&rft.volume=21&rft.issue=supp+4&rft.spage=S98&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.05.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Women; Veterans; Advocacy services; Observational research DO - http://dx.doi.org/10.1016/j.whi.2011.05.004 ER - TY - JOUR T1 - Measurement of Military Combat Exposure Among Women: Analysis and Implications AN - 1038112073; 201223556 AB - Purpose: To examine combat exposure measurement instruments utilized since the Vietnam War, determine how these instruments were developed and psychometrically tested, and if they are appropriate for use with women veterans exposed to combat. Methods: A literature search for articles concerning combat exposure instruments, their development, and their psychometric properties in relation to women was conducted in several electronic databases. Limited MeSH subject headings required keyword searches with terms such as combat stress, war trauma, and deployment stressors. Instruments were selected for analysis based on their inclusion of combat and combat-related traumatic event measures. Results: Eight instruments were retained for critical appraisal. The majority of instruments were developed and validated based on male veterans' combat experiences from the Vietnam War through the Gulf War. Located instruments explained their methodological development and indicated the type of exposure being measured. Reliability measures for the majority were acceptable, and validity was established to varying degrees and with different methods. Limitations of all instruments included retrospective self-reporting, potential recall error, and the inability to validate individual exposure objectively. Conclusion: Women veterans are substantially under-represented in the development and psychometric testing of combat exposure instruments, indicating a male gender bias in most combat measures. Only two instruments utilized women veterans in their validation samples, and six instruments used gender-neutral terminology. Instruments developed and validated with male veterans for specific military conflicts may not reflect the combat experiences of women. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Sternke, Lisa Marie AD - 109 Bee Street, Charleston, SC 29401 Phone: +(843) 367-5472, Fax: +(843) 556-7759 Lisa.Sternke@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - S160 EP - S168 PB - Elsevier Science, New York NY VL - 21 IS - supp 4 SN - 1049-3867, 1049-3867 KW - Veterans KW - Subject headings KW - Measurement KW - Vietnam War KW - Men KW - Women KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038112073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Measurement+of+Military+Combat+Exposure+Among+Women%3A+Analysis+and+Implications&rft.au=Sternke%2C+Lisa+Marie&rft.aulast=Sternke&rft.aufirst=Lisa&rft.date=2011-07-01&rft.volume=21&rft.issue=supp+4&rft.spage=S160&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.020 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Women; Veterans; Men; Vietnam War; Measurement; Subject headings DO - http://dx.doi.org/10.1016/j.whi.2011.04.020 ER - TY - JOUR T1 - Military Sexual Trauma and Patient Perceptions of Veteran Health Administration Health Care Quality AN - 1038111283; 201222832 AB - Background: Although sexual trauma is associated with poorer patient perceptions of health care quality, few studies have investigated this relationship in settings with comprehensive policies surrounding detection and treatment of sexual trauma, such as the Veterans Health Administration (VHA). We examined the association of military sexual trauma (MST) with patient satisfaction with VHA outpatient care among men and women. Methods: This is a cross-sectional study of a national representative sample of 164,632 VHA outpatients (5,758 women and 158,884 men) from fiscal year 2007. Measures included MST status, patients' ratings of overall satisfaction with VHA care in the last 2 months, and nine other dimensions of patient satisfaction. We assessed bivariate and multivariate associations between MST and overall satisfaction and each dimension of patient satisfaction. Multivariate models were adjusted for demographic characteristics, health status, and medical utilization. All analyses were stratified by gender. Findings: The proportion of patients reporting very good or excellent overall satisfaction was 78.5% for men and 72.3% for women. Findings showed that, once confounding was controlled, men and women veterans' MST status was not associated with satisfaction ratings of VHA health care overall. However, women veterans with a history of MST rated the dimensions of overall coordination and education and information less favorably than women veterans without an MST history. Post hoc analysis of individual items in these domains suggested that areas of improvement might include greater attention to provider-patient communication, including communication across multiple providers. There was no association between men's MST status and subdomains of health care satisfaction. Conclusion: Patient ratings of overall satisfaction of VHA care are high. Opportunities exist, however, to educate providers on the special coordination needs of female veterans with histories of MST. These female veterans might benefit from care coordination. When investigating satisfaction in patients with histories of sexual trauma, our findings suggest the importance of adjusting analyses for important patient characteristics. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Kimerling, Rachel AU - Pavao, Joanne AU - Valdez, Courtney AU - Mark, Hanna AU - Hyun, Jenny K AU - Saweikis, Meghan AD - VA Palo Alto Health Care System, National Center for PTSD, 795 Willow Road (334-PTSD), Menlo Park, CA 94025 Phone: +650-493-5000, ext. 23218, Fax: +650-617-2701 rachel.kimerling@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - S145 EP - S151 PB - Elsevier Science, New York NY VL - 21 IS - supp 4 SN - 1049-3867, 1049-3867 KW - Veterans KW - Coordination KW - Health care KW - Patient satisfaction KW - Women KW - Military hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038111283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Military+Sexual+Trauma+and+Patient+Perceptions+of+Veteran+Health+Administration+Health+Care+Quality&rft.au=Kimerling%2C+Rachel%3BPavao%2C+Joanne%3BValdez%2C+Courtney%3BMark%2C+Hanna%3BHyun%2C+Jenny+K%3BSaweikis%2C+Meghan&rft.aulast=Kimerling&rft.aufirst=Rachel&rft.date=2011-07-01&rft.volume=21&rft.issue=supp+4&rft.spage=S145&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Veterans; Patient satisfaction; Coordination; Military hospitals; Women; Health care DO - http://dx.doi.org/10.1016/j.whi.2011.04.007 ER - TY - JOUR T1 - Tailoring VA Primary Care to Women Veterans: Association with Patient-Rated Quality and Satisfaction AN - 1038111266; 201223741 AB - Background: Primary care delivery models tailored to women's needs and preferences are associated with higher quality and satisfaction. Therefore, the U.S. Department of Veterans Affairs (VA) recommends adoption of designated providers for women in primary care clinics or women's health centers as the optimal models for women's primary care. We assessed women veterans' ratings of their VA health care quality, gender-related satisfaction, gender appropriateness, and VA provider skills in treating women, in relation to primary care model at VA sites nationwide. Methods: Health care ratings were obtained from VA users in the 2008-2009 National Survey of Women Veterans. VA administrative data identified the site for each respondent's primary care. Facility data identified the site's primary care model for women. We conducted multilevel modeling to compare health care ratings for sites serving 300 or more women veterans who had adopted VA recommendations for women's primary care models (adopter sites), with non-adopter sites, and with small sites serving fewer women veterans, adjusting for patient characteristics. Results: Adopter sites received higher adjusted ratings of gender-related satisfaction and perceptions of VA provider skills than non-adopter and small sites. Adopter sites also received higher adjusted ratings of gender appropriateness than small sites. Adjusted ratings of quality of care did not differ by type of site. Conclusion: VA sites with primary care models tailored to women were rated higher on most dimensions of care. Facilitating establishment of these optimal care models at other sites is one strategy for improving women veterans' experiences with VA care. Research to identify other features of care associated with quality could inform ongoing VA quality transformation efforts. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Washington, Donna L AU - Bean-Mayberry, Bevanne AU - Mitchell, Michael N AU - Riopelle, Deborah AU - Yano, Elizabeth M AD - VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., 111G, Los Angeles, CA 90073 Phone: +310-478-3711, Fax: +310-268-4933 donna.washington@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - S112 EP - S119 PB - Elsevier Science, New York NY VL - 21 IS - supp 4 SN - 1049-3867, 1049-3867 KW - Veterans KW - Quality of care KW - Health care KW - Gender KW - Women KW - Primary health care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038111266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Tailoring+VA+Primary+Care+to+Women+Veterans%3A+Association+with+Patient-Rated+Quality+and+Satisfaction&rft.au=Washington%2C+Donna+L%3BBean-Mayberry%2C+Bevanne%3BMitchell%2C+Michael+N%3BRiopelle%2C+Deborah%3BYano%2C+Elizabeth+M&rft.aulast=Washington&rft.aufirst=Donna&rft.date=2011-07-01&rft.volume=21&rft.issue=supp+4&rft.spage=S112&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Women; Primary health care; Veterans; Quality of care; Health care; Gender DO - http://dx.doi.org/10.1016/j.whi.2011.04.004 ER - TY - JOUR T1 - Leading the Nation in Women's Health: The Important Role of Research AN - 1038111011; 201222635 AB - Over the past two decades, the Veterans Health Administration has supported numerous initiatives to remedy gaps in the services available to women veterans. As more women are entering and serving in the military, the organization is challenged to understand and treat the effects of military service on women's lives. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Hayes, Patricia M AD - VA Central Office, Women Veterans Health Strategic Health Care Group, 1717 H Street, NW, Washington, DC 20420 Phone: +202-461-1048, Fax: +202-273-9078 Patricia.Hayes@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - S70 EP - S72 PB - Elsevier Science, New York NY VL - 21 IS - supp 4 SN - 1049-3867, 1049-3867 KW - Health initiatives KW - Military service KW - Medical research KW - Women KW - Women's issues KW - Health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038111011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Leading+the+Nation+in+Women%27s+Health%3A+The+Important+Role+of+Research&rft.au=Hayes%2C+Patricia+M&rft.aulast=Hayes&rft.aufirst=Patricia&rft.date=2011-07-01&rft.volume=21&rft.issue=supp+4&rft.spage=S70&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.028 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Women; Health; Medical research; Health initiatives; Military service; Women's issues DO - http://dx.doi.org/10.1016/j.whi.2011.04.028 ER - TY - JOUR T1 - Evolving Comprehensive VA Women's Health Care: Patient Characteristics, Needs, and Preferences AN - 1038110867; 201223068 AB - Background: Assessment of women veterans' health needs and preferences and their care environment have been identified as a priority research need by the national Veterans Affairs (VA) Women's Health research agenda. Our objective was to identify women veterans' health care preferences and perceptions associated with sole or dual VA health care use. Methods: This cross-sectional study of 1,002 VA-enrolled Midwestern veterans was performed by computer-assisted telephone interviews. Results: Sole and dual (both VA and non-VA) users of VA care were more likely to have served in a combat area, have a current diagnosis of posttraumatic stress disorder, and poorer physical health scores than non-VA users. Non-VA users were more likely to be married and have private health insurance. Sole VA users were more likely to want a choice of a male or female health care provider. Both sole and dual VA users believed that the VA provides adequate privacy and safety during outpatient examinations compared with non-users. Urban women veterans were more likely to endorse specific environment of care preferences such as gender-specific waiting areas compared with rural veterans. Conclusion: Care preferences were similar regardless of VA use; however, perceptions of VA care varied. Women using VA care solely had the most positive perceptions of VA care, followed by dual users then non-VA users. Rural women were similar to urban veterans, but were less likely to endorse specific care preferences. Considering these differences with regard to need and access can inform VA policy and initiatives on improving access to and use of VA care among women veterans in urban and rural areas. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Mengeling, Michelle A AU - Sadler, Anne G AU - Torner, James AU - Booth, Brenda M AD - The Center for Comprehensive Access and Delivery Research and Evaluation, Iowa City VA Medical Center, 601 Highway 6 West, Iowa City, IA 52246 Phone: +319 338 0581 x7703, Fax: +319 887 4932 michelle.mengeling@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - S120 EP - S129 PB - Elsevier Science, New York NY VL - 21 IS - supp 4 SN - 1049-3867, 1049-3867 KW - Veterans KW - Perceptions KW - Health care KW - Preferences KW - Women KW - Women's issues KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038110867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Evolving+Comprehensive+VA+Women%27s+Health+Care%3A+Patient+Characteristics%2C+Needs%2C+and+Preferences&rft.au=Mengeling%2C+Michelle+A%3BSadler%2C+Anne+G%3BTorner%2C+James%3BBooth%2C+Brenda+M&rft.aulast=Mengeling&rft.aufirst=Michelle&rft.date=2011-07-01&rft.volume=21&rft.issue=supp+4&rft.spage=S120&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.021 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Veterans; Women; Preferences; Women's issues; Health care; Perceptions DO - http://dx.doi.org/10.1016/j.whi.2011.04.021 ER - TY - JOUR T1 - National Variations in VA Mental Health Care for Women Veterans AN - 1038110741; 201223200 AB - Objectives: Although the Veterans Health Administration (VA) has recently adopted new policies encouraging gender-specific mental health (MH) care delivery to women veterans, little is known about the potential difficulties local facilities may face in achieving compliance. We assessed variations in women's mental health care delivery arrangements in VA facilities nationwide. Methods: We used results from the VA Survey of Women Veterans Health Programs, a key informant survey of senior women's health clinicians representing all VA facilities serving more than 300 women veterans, to assess the array of gender-sensitive mental health care arrangements (response rate, 86%; n = 195). We also examined organizational and area factors related to availability of women's specialty mental health arrangements using multivariable logistic regression. Results: Nationally, over half (53%) of VA facilities had some form of gender-sensitive mental health care arrangements. Overall, 34% of sites reported having designated women's mental health providers in general outpatient mental health clinics (MHCs). Almost half (48%) had therapy groups for women in their MHCs. VAs with women's primary care clinics also delivered mental health services (24%), and 12% of VAs reported having a separate women's MHC, most of which (88%) offered sexual trauma group counseling. Assignment to same-gender mental health providers is not routine. VAs with comprehensive women's primary care clinics were more likely to integrate mental health care for women as well. Conclusion: Local implementation of gender-sensitive mental health care in VA settings is highly variable. Although this variation may reflect diverse local needs and resources, women veterans may also sometimes face challenges in accessing needed services. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Oishi, Sabine M AU - Rose, Danielle E AU - Washington, Donna L AU - MacGregor, Casey AU - Bean-Mayberry, Bevanne AU - Yano, Elizabeth M AD - VA HSR&D Center of Excellence for the Study of Healthcare Provider Behavior, VA Greater Los Angeles Healthcare System, 16111 Plummer St (152) Sepulveda, CA 91343 Phone: +818-891-7711, x5747, Fax: +818-895-5838 sabine.oishi@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - S130 EP - S137 PB - Elsevier Science, New York NY VL - 21 IS - supp 4 SN - 1049-3867, 1049-3867 KW - Veterans KW - Mental health care KW - Women KW - Women's issues KW - Mental health KW - Clinics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038110741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=National+Variations+in+VA+Mental+Health+Care+for+Women+Veterans&rft.au=Oishi%2C+Sabine+M%3BRose%2C+Danielle+E%3BWashington%2C+Donna+L%3BMacGregor%2C+Casey%3BBean-Mayberry%2C+Bevanne%3BYano%2C+Elizabeth+M&rft.aulast=Oishi&rft.aufirst=Sabine&rft.date=2011-07-01&rft.volume=21&rft.issue=supp+4&rft.spage=S130&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.029 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Women; Women's issues; Mental health care; Veterans; Mental health; Clinics DO - http://dx.doi.org/10.1016/j.whi.2011.04.029 ER - TY - JOUR T1 - "Homelessness and Trauma Go Hand-in-Hand": Pathways to Homelessness among Women Veterans AN - 1038110462; 201222608 AB - Background: Veterans comprise a disproportionate fraction of the nation's homeless population, with women veterans up to four times more likely to be homeless than non-veteran women. This paper provides a grounded description of women veterans' pathways into homelessness. Methods: Three focus groups were held in Los Angeles, California, with a total of 29 homeless women veterans. Results: Five predominant "roots" (precipitating experiences) initiated pathways toward homelessness: 1) childhood adversity, 2) trauma and/or substance abuse during military service, 3) post-military abuse, adversity, and/or relationship termination, 4) post-military mental health, substance abuse, and/or medical problems, and 5) unemployment. Contextual factors, which promoted development of homelessness in the setting of primary roots, included women veterans' "survivor instinct," lack of social support and resources, sense of isolation, pronounced sense of independence, and barriers to care. These contextual factors also reinforced persistence of the roots of post-military adversity and mental health and substance abuse problems, serving to maintain cycles of chronic homelessness. Conclusion: Collectively, these multiple, interacting roots and contextual factors form a "web of vulnerability" that is a target for action. Multiple points along the pathways to homelessness represent critical junctures for VA and community-based organizations to engage in prevention or intervention efforts on behalf of women veterans. Considering the multiple, interconnected challenges that these women veterans described, solutions to homelessness should address multiple risk factors, include trauma-informed care that acknowledges women veterans' traumatic experiences, and incorporate holistic responses that can contribute to healing and recovery. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Hamilton, Alison B AU - Poza, Ines AU - Washington, Donna L AD - Research Health Scientist & Investigator, VA HSR&D Center of Excellence for the Study of Healthcare Provider Behavior, 11301 Wilshire Blvd (210A), Los Angeles, CA 90073 Phone: +310-570-7411, Fax: +310-268-4056 Alison_hamilton@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - S203 EP - S209 PB - Elsevier Science, New York NY VL - 21 IS - supp 4 SN - 1049-3867, 1049-3867 KW - Veterans KW - Women KW - Adversity KW - Substance abuse KW - Homeless women KW - Homelessness KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038110462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=%22Homelessness+and+Trauma+Go+Hand-in-Hand%22%3A+Pathways+to+Homelessness+among+Women+Veterans&rft.au=Hamilton%2C+Alison+B%3BPoza%2C+Ines%3BWashington%2C+Donna+L&rft.aulast=Hamilton&rft.aufirst=Alison&rft.date=2011-07-01&rft.volume=21&rft.issue=supp+4&rft.spage=S203&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Veterans; Homelessness; Women; Substance abuse; Homeless women; Adversity DO - http://dx.doi.org/10.1016/j.whi.2011.04.005 ER - TY - JOUR T1 - New Women Veterans in the VHA: A Longitudinal Profile AN - 1038109762; 201222493 AB - Objective: The number of women veterans using Veterans Health Administration (VHA) services has increased rapidly, but the characteristics of women joining VHA are not well understood. We sought to describe sociodemographic characteristics, utilization, and retention of new and returning women VHA patients over a 7-year period. Methods: We identified women veterans who used VHA outpatient services from VHA Enrollment and Utilization files for fiscal years 2003 through 2009. "New" patients in a given year had no outpatient use within the prior 3 years. Patients were "retained" if they continued to use VHA in subsequent years. Main Findings: Of the 287,447 women veteran VHA outpatients in 2009, 40,000 (14%) were new to VHA in that year and over half had joined VHA since 2003. Nearly two thirds of these new patients were younger than 45, and 43% carried a service-connected disability status. Most new patients (88%) received primary care services in 2008, and 40% used mental health services. Repeated use of mental health services (at least three visits per year) nearly doubled among new patients (from 11% in 2003 to 20% in 2008). Among those using VHA primary care in 2006, 68% of new patients versus 91% of returning patients were retained in either of the subsequent 2 years. Conclusion: The influx of new women veterans seeking VHA services in recent years, combined with their high rate of retention within VHA, contribute to the marked increase in numbers of women veterans using VHA. Many require fairly intensive VHA services. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Friedman, Sarah A AU - Phibbs, Ciaran S AU - Schmitt, Susan K AU - Hayes, Patricia M AU - Herrera, Laura AU - Frayne, Susan M AD - Centre for Health Care Evaluation, VA Palo Alto Health Care System, 795 Willow Road (152-MPD), Menlo Park, CA 94025 Phone: +650/493-500 x23369, Fax: +650/617-2690 Y1 - 2011/07// PY - 2011 DA - July 2011 SP - S103 EP - S111 PB - Elsevier Science, New York NY VL - 21 IS - supp 4 SN - 1049-3867, 1049-3867 KW - Veterans KW - Mental health services KW - Women KW - Primary health care KW - Retention KW - Military hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038109762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=New+Women+Veterans+in+the+VHA%3A+A+Longitudinal+Profile&rft.au=Friedman%2C+Sarah+A%3BPhibbs%2C+Ciaran+S%3BSchmitt%2C+Susan+K%3BHayes%2C+Patricia+M%3BHerrera%2C+Laura%3BFrayne%2C+Susan+M&rft.aulast=Friedman&rft.aufirst=Sarah&rft.date=2011-07-01&rft.volume=21&rft.issue=supp+4&rft.spage=S103&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.025 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Women; Veterans; Mental health services; Primary health care; Retention; Military hospitals DO - http://dx.doi.org/10.1016/j.whi.2011.04.025 ER - TY - JOUR T1 - Systematic Review of Women Veterans' Health: Update on Successes and Gaps AN - 1038109604; 201222035 AB - Objective: We assessed the state of women veterans' health research by conducting a systematic review of scientific literature published from 2004 to 2008, updating a prior review spanning the history of this literature to 2004. Methods: We identified articles by searching scientific databases and contacting experts. Relevant articles were independently evaluated by two physician reviewers. We categorized 195 articles by study design, funding source, period of military service, research topic, and health condition. Results: More research was published during this 5-year review (n = 195) than in the 25 years beforehand (n = 182). The 195 studies included five trials, but only one randomized trial, a study that examined treatment outcomes for women with posttraumatic stress disorder (PTSD). The large number of articles focused on Operation Enduring Freedom and Operation Iraqi Freedom (OEF/OIF) soldiers' health issues (n = 23) reflects the growing participation of women in these conflicts. High rates of positive PTSD symptoms (range, 10%-19%) and other mental health disorders were found among OEF/OIF returning military women. The recent post-deployment literature underscores the need for repeated PTSD/mental health screening in returning veterans, and points to continuity of care needs for psychiatric and gynecological problems which occur in the field. The psychiatric and access/utilization literature confirmed the positive relationship between military sexual trauma and PTSD and the associated negative health effects. Conclusion: Although most VA women's health research remains observational, methods are evolving toward an analytical focus. Even though successes are evident in the breadth and depth of publications, remaining gaps in the literature include post-deployment readjustment for veterans/families, and quality-of-care interventions/outcomes for physical and mental conditions. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Bean-Mayberry, Bevanne AU - Yano, Elizabeth M AU - Washington, Donna L AU - Goldzweig, Caroline AU - Batuman, Fatma AU - Huang, Christine AU - Miake-Lye, Isomi AU - Shekelle, Paul G AD - VA GLA HSR&D Center for Study of Healthcare Provider Behavior, VA Sepulveda, 16111 Plummer St (152), Sepulveda, CA 91343 Phone: +818-895-9449, Fax: +818-895-5838 bevanne.bean-mayberry@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - S84 EP - S97 PB - Elsevier Science, New York NY VL - 21 IS - supp 4 SN - 1049-3867, 1049-3867 KW - Veterans KW - Posttraumatic stress disorder KW - Medical research KW - Women KW - Women's issues KW - Health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038109604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Systematic+Review+of+Women+Veterans%27+Health%3A+Update+on+Successes+and+Gaps&rft.au=Bean-Mayberry%2C+Bevanne%3BYano%2C+Elizabeth+M%3BWashington%2C+Donna+L%3BGoldzweig%2C+Caroline%3BBatuman%2C+Fatma%3BHuang%2C+Christine%3BMiake-Lye%2C+Isomi%3BShekelle%2C+Paul+G&rft.aulast=Bean-Mayberry&rft.aufirst=Bevanne&rft.date=2011-07-01&rft.volume=21&rft.issue=supp+4&rft.spage=S84&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.022 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Health; Women; Posttraumatic stress disorder; Veterans; Women's issues; Medical research DO - http://dx.doi.org/10.1016/j.whi.2011.04.022 ER - TY - JOUR T1 - Aided cortical auditory evoked potentials in response to changes in hearing aid gain AN - 1023090968; 201212872 AB - Objective: There is interest in using cortical auditory evoked potentials (CAEPs) to evaluate hearing aid fittings and experience-related plasticity associated with amplification; however, little is known about hearing aid signal processing effects on these responses. The purpose of this study was to determine the effect of clinically relevant hearing aid gain settings, and the resulting in-the-canal signal-to-noise ratios (SNRs), on the latency and amplitude of P1, N1, and P2 waves. Design & Sample: Evoked potentials and in-the-canal acoustic measures were recorded in nine normal-hearing adults in unaided and aided conditions. In the aided condition, a 40-dB signal was delivered to a hearing aid programmed to provide four levels of gain (0, 10, 20, and 30 dB). As a control, unaided stimulus levels were matched to aided condition outputs (i.e. 40, 50, 60, and 70 dB) for comparison purposes. Results: When signal levels are defined in terms of output level, aided CAEPs were surprisingly smaller and delayed relative to unaided CAEPs, probably resulting from increases to noise levels caused by the hearing aid. Discussion: These results reinforce the notion that hearing aids modify stimulus characteristics such as SNR, which in turn affects the CAEP in a way that does not reliably reflect hearing aid gain. Adapted from the source document. JF - International Journal of Audiology AU - Billings, Curtis J AU - Tremblay, Kelly L AU - Miller, Christi W AD - National Center for Rehabilitative Auditory Research, Portland VA Medical Center curtis.billings2@va.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 459 EP - 467 PB - Informa Healthcare, Taylor and Francis, London UK VL - 50 IS - 7 SN - 1499-2027, 1499-2027 KW - Cortical auditory evoked potentials (CAEPs), Event-related potentials (ERPs), Signals in noise, Signal-to-noise ratio (SNR), N1, Auditory cortex, Hearing aids, Amplification KW - Stimulus KW - Noise KW - Signals KW - Plasticity KW - Hearing KW - Auditory evoked brain potential KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023090968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=Aided+cortical+auditory+evoked+potentials+in+response+to+changes+in+hearing+aid+gain&rft.au=Billings%2C+Curtis+J%3BTremblay%2C+Kelly+L%3BMiller%2C+Christi+W&rft.aulast=Billings&rft.aufirst=Curtis&rft.date=2011-07-01&rft.volume=50&rft.issue=7&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/10.3109%2F14992027.2011.568011 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hearing; Signals; Auditory evoked brain potential; Stimulus; Plasticity; Noise DO - http://dx.doi.org/10.3109/14992027.2011.568011 ER - TY - JOUR T1 - Characteristics and VA Health Care Utilization of U.S. Veterans Who Completed Suicide in Oregon Between 2000 and 2005 AN - 925714095; 201201125 AB - Oregon Violent Death Reporting System data were linked with Veterans Affairs (VA) administrative data to identify and describe veterans who completed suicide in Oregon from 2000 to 2005 (n = 968), and to describe their VA health care utilization in the year prior to death. Twenty-two percent had received health care in the VA system. Of these, 57% did not have mental health diagnoses and 58% had not seen mental health professionals. A larger proportion of those who accessed care were VA-enrolled and received service-connected disability benefits. Fifty-five veterans were hospitalized during the year prior to death. Of these, 33% completed suicide within 30 days of a hospitalization. Further development of suicide prevention strategies for veterans in the community, including general medical treatment settings, is indicated. Adapted from the source document. JF - Suicide and Life-Threatening Behavior AU - Basham, Chandra AU - Denneson, Lauren M AU - Millet, Lisa AU - Shen, Xun AU - Duckart, Jonathan AU - Dobscha, Steven K AD - Portland VA Medical Center, P.O. Box 1034 (P3DEP_PC), Portland, OR 97207 Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 287 EP - 296 PB - Guilford Publications, New York NY VL - 41 IS - 3 SN - 0363-0234, 0363-0234 KW - Veterans KW - Oregon KW - Prevention KW - Methodology (Data Collection) KW - Death KW - Suicide KW - Mental Health KW - Health Care Utilization KW - Health Care Services KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925714095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Suicide+and+Life-Threatening+Behavior&rft.atitle=Characteristics+and+VA+Health+Care+Utilization+of+U.S.+Veterans+Who+Completed+Suicide+in+Oregon+Between+2000+and+2005&rft.au=Basham%2C+Chandra%3BDenneson%2C+Lauren+M%3BMillet%2C+Lisa%3BShen%2C+Xun%3BDuckart%2C+Jonathan%3BDobscha%2C+Steven+K&rft.aulast=Basham&rft.aufirst=Chandra&rft.date=2011-06-01&rft.volume=41&rft.issue=3&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Suicide+and+Life-Threatening+Behavior&rft.issn=03630234&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SLBEDP N1 - SubjectsTermNotLitGenreText - Veterans; Suicide; Oregon; Death; Mental Health; Health Care Utilization; Methodology (Data Collection); Health Care Services; Prevention ER - TY - JOUR T1 - Exposure Therapy for PTSD Delivered to Veterans via Telehealth: Predictors of Treatment Completion and Outcome and Comparison to Treatment Delivered in Person AN - 908020811; 201121647 AB - Recent research has focused on the effectiveness of evidence-based psychotherapy delivered via telehealth services. Unfortunately to date, the majority of studies employ very small samples and limited predictor and moderator variables. To address these concerns and further replicate and extend the literature on telehealth, the present study investigated the effectiveness of 12-session exposure therapy delivered either via telehealth (n = 62) or in person (n = 27) in veterans with posttraumatic stress disorder (PTSD). Findings demonstrated that although older veterans and Vietnam veterans were more likely to complete the telehealth treatment, telehealth findings were not influenced by patient age, sex, race, combat theater, or disability status. Exposure therapy delivered via telehealth was effective in reducing the symptoms of PTSD, anxiety, depression, stress, and general impairment with large effect sizes. Interestingly, exposure therapy via telehealth was less effective than exposure therapy delivered in person; however, lack of random assignment to condition limits conclusions of differential effectiveness. Overall, these findings support the utility of telehealth services to provide effective, evidence-based psychotherapies. [Copyright Association for Behavioral and Cognitive Therapies. Published by Elsevier Ltd.] JF - Behavior Therapy AU - Gros, Daniel F AU - Yoder, Matthew AU - Tuerk, Peter W AU - Lozano, Brian E AU - Acierno, Ron AD - Ralph H. Johnson Veterans Administration Medical Center and Medical University of South Carolina grosd@musc.edu Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 276 EP - 283 PB - Elsevier Ltd, The Netherlands VL - 42 IS - 2 SN - 0005-7894, 0005-7894 KW - Veterans KW - Posttraumatic stress disorder KW - Exposure therapy KW - Psychotherapy KW - Telemedicine KW - Anxiety-Depression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/908020811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Therapy&rft.atitle=Exposure+Therapy+for+PTSD+Delivered+to+Veterans+via+Telehealth%3A+Predictors+of+Treatment+Completion+and+Outcome+and+Comparison+to+Treatment+Delivered+in+Person&rft.au=Gros%2C+Daniel+F%3BYoder%2C+Matthew%3BTuerk%2C+Peter+W%3BLozano%2C+Brian+E%3BAcierno%2C+Ron&rft.aulast=Gros&rft.aufirst=Daniel&rft.date=2011-06-01&rft.volume=42&rft.issue=2&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Behavior+Therapy&rft.issn=00057894&rft_id=info:doi/10.1016%2Fj.beth.2010.07.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Telemedicine; Exposure therapy; Veterans; Posttraumatic stress disorder; Psychotherapy; Anxiety-Depression DO - http://dx.doi.org/10.1016/j.beth.2010.07.005 ER - TY - JOUR T1 - Facilitators and Barriers in Implementing Buprenorphine in the Veterans Health Administration AN - 902097222; 201119511 AB - Opioid dependence is a chronic, relapsing disorder that deleteriously influences the health of those afflicted. Sublingual buprenorphine opioid agonist treatment (OAT) has been shown to be safe, effective, and cost-effective for the treatment of opioid dependence in nonspecialized, office-based settings, including the Veterans Health Administration (VHA). We sought to examine and describe provider-, facility-, and system-level barriers and facilitators to implementing buprenorphine therapy within the VHA. From June 2006 to October 2007, we conducted semistructured telephone interviews of key personnel at a national sample of VHA facilities with high prevalence of opioid dependence and without methadone OAT programs. Sites were categorized based on the number of veterans receiving buprenorphine prescriptions: More Buprenorphine (MB, 40 prescriptions, 5 sites), Some Buprenorphine (SB, 5-40 prescriptions, 3 sites), and No Buprenorphine (NB, 0-5 prescriptions, 9 sites). Interviews were taped, transcribed, and coded; consensus of coding themes was reached; and data were evaluated using grounded theory. Sixty-two staff members were interviewed. For NB sites, perceived patient barriers included lack of need and attitudes/stigma associated with opioid dependence. Provider barriers included lack of interest, stigma toward the population, and lack of education about buprenorphine-OAT. Prominent facilitators at MB sites included having established need, provider interest, and resources/time available for buprenorphine-OAT. The presence of a champion/role-model for buprenorphine care greatly facilitated its implementation. We conclude that factors that enable or impede buprenorphine-OAT vary by facility. Strategies and policies to encourage implementation of buprenorphine should be adaptable and target needs of each facility. [Copyright The American Psychological Association.] JF - Psychology of Addictive Behaviors AU - Gordon, Adam J AU - Kavanagh, Greg AU - Krumm, Margaret AU - Ramgopal, Rajeev AU - Paidisetty, Sanjay AU - Aghevli, Minu AU - Goodman, Francine AU - Trafton, Jodie AU - Liberto, Joseph AD - Mental Illness Research, Education, and Clinical Center and Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania adam.gordon@va.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 215 EP - 224 PB - American Psychological Association, Washington DC VL - 25 IS - 2 SN - 0893-164X, 0893-164X KW - opioid-related disorders buprenorphine United States Department of Veterans Affairs KW - Prescriptions KW - Buprenorphine KW - Health KW - Facilitators KW - Drug dependency KW - Military hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902097222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Addictive+Behaviors&rft.atitle=Facilitators+and+Barriers+in+Implementing+Buprenorphine+in+the+Veterans+Health+Administration&rft.au=Gordon%2C+Adam+J%3BKavanagh%2C+Greg%3BKrumm%2C+Margaret%3BRamgopal%2C+Rajeev%3BPaidisetty%2C+Sanjay%3BAghevli%2C+Minu%3BGoodman%2C+Francine%3BTrafton%2C+Jodie%3BLiberto%2C+Joseph&rft.aulast=Gordon&rft.aufirst=Adam&rft.date=2011-06-01&rft.volume=25&rft.issue=2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/10.1037%2Fa0022776 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - CODEN - PABEEI N1 - SubjectsTermNotLitGenreText - Buprenorphine; Prescriptions; Drug dependency; Health; Facilitators; Military hospitals DO - http://dx.doi.org/10.1037/a0022776 ER - TY - JOUR T1 - Quantifying the reduction in non-medical costs after the introduction of a rural county hospital in Ecuador AN - 901182719; 4244589 AB - ABSTRACT IN ENGLISH: Objective: This study attempts to quantify the impact of the introduction of local second-level health service on non-medical costs (NMCs) for residents of the rural Ecuadorian county of La Maná. Methods: NMCs for patients accessing second-level health care were assessed by using a quasi-experimental pre- and post-intervention study design. In 2007, before local second-level health care services existed, and then in 2008, after the introduction of second-level health care services in the form of a county hospital, 508 patients from the county who sought second-level health care were interviewed. Results: Mean NMCs per patient per illness episode were US$ 93.58 before the county hospital opened and US$ 12.62 after it opened. This difference was largely due to reductions in transport costs (US$ 50.01 vs. US$ 4.28) and food costs (US$ 25.38 vs. US$ 7.28) (P < 0.001 for each category). Conclusions: NMCs can be decreased sevenfold with the introduction of a county hospital in a rural province previously lacking second-level health care. Introduction of rural second-level health care reduces financial barriers and thus may increase access to these health services for poorer patients in rural communities. // ABSTRACT IN SPANISH: Objetivo: Este estudio tiene por objeto cuantificar la repercusión de la introducción de servicios de salud locales de segundo nivel sobre los costos no médicos para los residentes del cantón rural ecuatoriano de La Maná. Métodos: Se evaluaron los costos no médicos de los pacientes que tuvieron acceso a atención médica de segundo nivel mediante un estudio cuasiexperimental de análisis previo y posterior a la intervención. En el 2007 (antes de que existieran servicios locales de este tipo) y en el 2008 (después de la introducción de atención médica de segundo nivel representada por el hospital del cantón) se entrevistaron a 508 pacientes del cantón que requirieron atención médica de segundo nivel. Resultados: Los costos no médicos medios por paciente y por episodio de enfermedad fueron de US$ 93,58 antes de la apertura del hospital local y de US$ 12,62 después de la inauguración del establecimiento. Esta diferencia se debió en gran parte a la reducción de los costes de transporte (US$ 50,01 frente a US$ 4,28) y los costes de alimentación (US$ 25,38 frente a US$ 7,28) (P < 0,001 para cada categoria). Conclusiones: Es posible reducir los costos no médicos a una séptima parte mediante la apertura de un hospital local en una zona rural que anteriormente carecía de atención médica de segundo nivel. La introducción de atención médica de segundo nivel en una zona rural reduce los obstáculos financieros y, por lo tanto, podría aumentar el acceso a estos servicios de salud para los pacientes más pobres en las comunidades rurales. JF - Pan American journal of public health AU - Gaus, David P AU - Herrera, Diego F AU - Mantyh, William G AU - Girdhari, Rajesh P AU - Kuskowski, Michael A AD - Andean Health and Development ; University of Minnesota ; University of Toronto ; Veterans Administration Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 423 EP - 427 VL - 29 IS - 6 SN - 1020-4989, 1020-4989 KW - Sociology KW - La Maná KW - Comparative analysis KW - Measurement KW - Ecuador KW - Diachronic analysis KW - Experimental methods KW - Counties KW - Patients KW - Economic impact analysis KW - Rural communities KW - Access to health care KW - Food expenditure KW - Transport costs KW - Cost analysis KW - Interviews KW - Poor KW - Hospitals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901182719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pan+American+journal+of+public+health&rft.atitle=Quantifying+the+reduction+in+non-medical+costs+after+the+introduction+of+a+rural+county+hospital+in+Ecuador&rft.au=Gaus%2C+David+P%3BHerrera%2C+Diego+F%3BMantyh%2C+William+G%3BGirdhari%2C+Rajesh+P%3BKuskowski%2C+Michael+A&rft.aulast=Gaus&rft.aufirst=David&rft.date=2011-06-01&rft.volume=29&rft.issue=6&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Pan+American+journal+of+public+health&rft.issn=10204989&rft_id=info:doi/10.1590%2FS1020-49892011000600007 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2920 971 2934 3883; 7854; 11157 2603; 6013 6590; 2957 10738 12092; 3942 3883 971; 9271 7890 5792 10484; 4631; 6832 10919; 3525 2258 12756 5873 971; 2630 971; 12939 2934; 5122 4618; 516 5775 13521; 9833; 120 386 14 DO - http://dx.doi.org/10.1590/S1020-49892011000600007 ER - TY - JOUR T1 - Vibrio furnissii: an Unusual Cause of Bacteremia and Skin Lesions after Ingestion of Seafood AN - 899145954; 15404137 AB - Vibrio furnissii in the blood is rarely reported, which may explain why clinical features of bloodstream infections with this organism have not been described. We describe a patient who developed skin lesions and V. furnissii bacteremia and was successfully treated with fluoroquinolones. V. furnissii may be a serious pathogen in patients with underlying comorbidities who are exposed to seafood. JF - Journal of Clinical Microbiology AU - Derber, Catherine AU - Coudron, Philip AU - Tarr, Cheryl AU - Gladney, Lori AU - Turnsek, Maryann AU - Shankaran, Shivanjali AU - Wong, Edward AD - Department of Medicine, Division of Infectious Diseases, Virginia Commonwealth University, Richmond, Virginia, Edward.wong@va.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 2348 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 49 IS - 6 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Blood KW - Skin diseases KW - Fluoroquinolones KW - Vibrio furnissii KW - Bacteremia KW - Seafood KW - Pathogens KW - Infection KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899145954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Vibrio+furnissii%3A+an+Unusual+Cause+of+Bacteremia+and+Skin+Lesions+after+Ingestion+of+Seafood&rft.au=Derber%2C+Catherine%3BCoudron%2C+Philip%3BTarr%2C+Cheryl%3BGladney%2C+Lori%3BTurnsek%2C+Maryann%3BShankaran%2C+Shivanjali%3BWong%2C+Edward&rft.aulast=Derber&rft.aufirst=Catherine&rft.date=2011-06-01&rft.volume=49&rft.issue=6&rft.spage=2348&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00092-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Number of references - 10 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Blood; Fluoroquinolones; Skin diseases; Bacteremia; Pathogens; Seafood; Infection; Vibrio furnissii DO - http://dx.doi.org/10.1128/JCM.00092-11 ER - TY - JOUR T1 - Effect of visual perspective on memory and interpretation in dysphoria AN - 896167662; 201118573 AB - When engaging in self-reflection, the visual perspective one adopts has important effects on emotional reactivity. Specifically, adopting a distanced stance, or viewing oneself from a third-person perspective, has been found to reduce emotional reactivity to negative autobiographical memories. The effect of adopting this perspective is moderated by depression such that reactivity is not reduced for individuals with particularly low levels of depressive symptoms. In the current study, we examine the effects of visual perspective on two forms of mental imagery in dysphoric and nondysphoric individuals. We attempt to replicate previous findings for recall of sad autobiographical memories and extend this research to interpretation of ambiguous situations. The results suggest that the effects of adopting a distanced stance are not moderated by depressive symptoms and do not extend from memories to interpretations of ambiguous situations. Visual perspective is associated with emotional reactivity to memories. We extend visual perspective research to interpretation imagery. Distanced perspective leads to reduced reactivity to memories, not interpretations. Similar effects found for dysphoric and nondysphoric individuals. [Copyright Elsevier Ltd.] JF - Behaviour Research and Therapy AU - Wisco, Blair E AU - Nolen-Hoeksema, Susan AD - Yale University, Psychology Department, 2 Hillhouse Ave., New Haven, CT 06511, USA blair.wisco@va.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 406 EP - 412 PB - Elsevier, Amsterdam The Netherlands VL - 49 IS - 6-7 SN - 0005-7967, 0005-7967 KW - Depression Interpretation Memory Observer perspective Distanced analysis KW - Memory KW - Depression KW - Moderated KW - Mental imagery KW - Reactivity KW - Autobiographical memory KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896167662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behaviour+Research+and+Therapy&rft.atitle=Effect+of+visual+perspective+on+memory+and+interpretation+in+dysphoria&rft.au=Wisco%2C+Blair+E%3BNolen-Hoeksema%2C+Susan&rft.aulast=Wisco&rft.aufirst=Blair&rft.date=2011-06-01&rft.volume=49&rft.issue=6-7&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Behaviour+Research+and+Therapy&rft.issn=00057967&rft_id=info:doi/10.1016%2Fj.brat.2011.03.012 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - CODEN - BRTHAA N1 - SubjectsTermNotLitGenreText - Reactivity; Depression; Memory; Autobiographical memory; Moderated; Mental imagery DO - http://dx.doi.org/10.1016/j.brat.2011.03.012 ER - TY - JOUR T1 - Phenotypic and Genotypic Screening and Clonal Analysis of Carbapenem-Resistant Klebsiella pneumoniae at a Single Hospital AN - 874197680; 15020508 AB - Detection of bla sub(KPC)-harbormg Klebsiella pneumoniae (KP) in the clinical laboratory remains a difficult task. Decreased ertapenem (ERT) susceptibility has been considered one of the most sensitive phenotypic indicators of K. pneumoniae carbapenemase (KPC) production, but has been found to be nonspecific. Susceptibility testing using imipenem or meropenem lacks the sensitivity for detection of KPCs, and there is limited experience using dor-ipenem (DOR). Fifty-five individual ERT-nonsusceptible KP isolates and 19 isolates that were ERT-susceptible, extended spectrum beta -lactamase-positive KP were collected from the clinical laboratory and tested for DOR susceptibility by Etest methodology. PCR screening for bla sub(KPC) was performed on all specimens. All but three isolates with ERT resistance were KPC positive by PCR. Compared to PCR, ERT detection of KPC had a sensitivity of 98% and a false-positive rate of 6%. Overall, there was a 97% agreement between ERT and DOR susceptibility results. However, there was one KPC-positive isolate that was discrepant (ERT susceptible, DOR nonsusceptible by Etest). Selected isolates of KP from both groups underwent pulsed-field gel electrophoresis analysis to determine the degree of genetic relatedness of KPC-positive and KPC-negative isolates. Pulsed-field gel electrophoresis of selected KPC-positive and KPC-negative KP identified a common pattern between both groups. The resistance to DOR and/or ERT is sensitive and a specific indicator for detection of bla sub(KPC) in KP. JF - Microbial Drug Resistance AU - Gomez, E AU - Urban, C AU - Mariano, N AU - Colon-Urban, R AU - Eng, RHK AU - Huang, D B AU - Chiang, T AD - VA NJHCS, 385 Tremont Ave., 111-1D, East Orange, NJ 07018, USA, Tom.Chiang@va.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 251 EP - 257 VL - 17 IS - 2 SN - 1076-6294, 1076-6294 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Meropenem KW - Drug resistance KW - ertapenem KW - Pulsed-field gel electrophoresis KW - Polymerase chain reaction KW - carbapenemase KW - Klebsiella pneumoniae KW - Imipenem KW - Hospitals KW - A 01350:Microbial Resistance KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874197680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Drug+Resistance&rft.atitle=Phenotypic+and+Genotypic+Screening+and+Clonal+Analysis+of+Carbapenem-Resistant+Klebsiella+pneumoniae+at+a+Single+Hospital&rft.au=Gomez%2C+E%3BUrban%2C+C%3BMariano%2C+N%3BColon-Urban%2C+R%3BEng%2C+RHK%3BHuang%2C+D+B%3BChiang%2C+T&rft.aulast=Gomez&rft.aufirst=E&rft.date=2011-06-01&rft.volume=17&rft.issue=2&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Microbial+Drug+Resistance&rft.issn=10766294&rft_id=info:doi/10.1089%2Fmdr.2010.0116 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Drug resistance; Meropenem; ertapenem; Pulsed-field gel electrophoresis; Polymerase chain reaction; carbapenemase; Hospitals; Imipenem; Klebsiella pneumoniae DO - http://dx.doi.org/10.1089/mdr.2010.0116 ER - TY - JOUR T1 - Do cardiomyocytes mount an immune response to Group A Streptococcus? AN - 867740676; 14783869 AB - Some patients with Group A Streptococcal toxic shock syndrome (StrepTSS) develop a unique form of cardiomyopathy characterized by global hypokinesia and reduced cardiac index. Here we investigated the immune responses of cardiomyocytes to Group A Streptococcus both in vivo and in vitro. Our data demonstrate that cardiomyocyte-derived cytokines are produced following both direct GAS stimulation and after exposure to GAS-activated inflammatory cells. These locally produced, cardiomyocyte-derived cytokines may mediate cardiac contractile dysfunction observed in patients with StrepTSS-associated cardiomyopathy and may hold the key to our ability to attenuate this severe complication. JF - Cytokine AU - Li, Zhi AU - Bryant, Amy E AU - Hamilton, Stephanie M AU - Bayer, Clifford R AU - Ma, Yongsheng AU - Stevens, Dennis L AD - Veterans Affairs Medical Center, Boise, ID, USA, Zhi.Li@va.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 258 EP - 265 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 54 IS - 3 SN - 1043-4666, 1043-4666 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Streptococcus KW - Heart KW - Cardiomyopathy KW - Muscle contraction KW - Data processing KW - Cytokines KW - streptococcal toxic shock syndrome KW - cardiomyocytes KW - Immune response KW - Heart diseases KW - Inflammation KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867740676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=Do+cardiomyocytes+mount+an+immune+response+to+Group+A+Streptococcus%3F&rft.au=Li%2C+Zhi%3BBryant%2C+Amy+E%3BHamilton%2C+Stephanie+M%3BBayer%2C+Clifford+R%3BMa%2C+Yongsheng%3BStevens%2C+Dennis+L&rft.aulast=Li&rft.aufirst=Zhi&rft.date=2011-06-01&rft.volume=54&rft.issue=3&rft.spage=258&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=10434666&rft_id=info:doi/10.1016%2Fj.cyto.2011.02.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Heart; Muscle contraction; Cardiomyopathy; Data processing; Cytokines; streptococcal toxic shock syndrome; Immune response; cardiomyocytes; Inflammation; Heart diseases; Streptococcus DO - http://dx.doi.org/10.1016/j.cyto.2011.02.009 ER - TY - JOUR T1 - Strategies to Implement Alcohol Screening and Brief Intervention in Primary Care Settings: A Structured Literature Review AN - 1823506471; 201121085 AB - Although alcohol screening and brief intervention (SBI) reduces drinking in primary care patients with unhealthy alcohol use, incorporating SBI into clinical settings has been challenging. We systematically reviewed the literature on implementation studies of alcohol SBI using a broad conceptual model of implementation, the Consolidated Framework for Implementation Research (CFIR), to identify domains addressed by programs that achieved high rates of screening and/or brief intervention (BI). Seventeen articles from 8 implementation programs were included; studies were conducted in 9 countries and represented 533,903 patients (127,304 patients screened), 2,001 providers, and 1,805 clinics. Rates of SBI varied across articles (2-93% for screening and 0.9-73.1% for BI). Implementation programs described use of 7-25 of the 39 CFIR elements. Most programs used strategies that spanned all 5 domains of the CFIR with varying emphases on particular domains and sub-domains. Comparison of SBI rates was limited by most studies' being conducted by 2 implementation programs and by different outcome measures, scopes, and durations. However, one implementation program reported a high rate of screening relative to other programs (93%) and could be distinguished by its use of strategies that related to the Inner Setting, Outer Setting, and Process of Implementation domains of the CFIR. Future studies could assess whether focusing on Inner Setting, Outer Setting, and Process of Implementation elements of the CFIR during implementation is associated with successful implementation of alcohol screening, as well as which elements may be associated with successful, sustained implementation of BI. [Copyright The American Psychological Association.] JF - Psychology of Addictive Behaviors AU - Williams, Emily C AU - Johnson, M Laura AU - Lapham, Gwen T AU - Caldeiro, Ryan M AU - Chew, Lisa AU - Fletcher, Grant S AU - McCormick, Kinsey A AU - Weppner, William G AU - Bradley, Katharine A AD - Health Services Research and Development, Department of Veterans Affairs, VA Puget Sound Health Care System, Seattle, Washington emily.williams3@va.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 206 EP - 214 PB - American Psychological Association, Washington DC VL - 25 IS - 2 SN - 0893-164X, 0893-164X KW - alcohol screening brief intervention systematic review implementation unhealthy alcohol use KW - Alcohol consumption KW - Screening KW - Brief interventions KW - Primary health care KW - Clinics KW - Conceptual models KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1823506471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Addictive+Behaviors&rft.atitle=Strategies+to+Implement+Alcohol+Screening+and+Brief+Intervention+in+Primary+Care+Settings%3A+A+Structured+Literature+Review&rft.au=Williams%2C+Emily+C%3BJohnson%2C+M+Laura%3BLapham%2C+Gwen+T%3BCaldeiro%2C+Ryan+M%3BChew%2C+Lisa%3BFletcher%2C+Grant+S%3BMcCormick%2C+Kinsey+A%3BWeppner%2C+William+G%3BBradley%2C+Katharine+A&rft.aulast=Williams&rft.aufirst=Emily&rft.date=2011-06-01&rft.volume=25&rft.issue=2&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/10.1037%2Fa0022102 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - CODEN - PABEEI N1 - SubjectsTermNotLitGenreText - Screening; Brief interventions; Primary health care; Alcohol consumption; Clinics; Conceptual models DO - http://dx.doi.org/10.1037/a0022102 ER - TY - JOUR T1 - Physiological Responses to Body Weight-Supported Treadmill Exercise in Healthy Adults AN - 1496888694; 14965357 AB - Hoffman, Donaghe HE. Physiological responses to body weight-supported treadmill exercise in healthy adults. Objective: To determine whether the relationships of heart rate, rating of perceived exertion (RPE), and ground reaction forces (GRFs) with oxygen consumption rate (o sub(2) during treadmill exercise are altered by partial body weight support (BWS) via lower-body positive pressure. Design: Repeated-measures design. Setting: Exercise physiology laboratory. Participants: Healthy, active adults (N=12); mean age +/- SD, 45.1+/-12.6 years. Interventions: Not applicable. Main Outcome Measures: o) sub(2), heart rate, RPE, and GRFs were measured during walking and running at 3 levels (0%, 25%, 50%) of BWS. Before exercise, standing heart rate and blood pressure were measured under each BWS condition. Results: Standing heart rates were 7 beats/min lower (P.05) and systolic blood pressures were 10mmHg higher (P.001) at 50% BWS compared with 0% BWS, but mean blood pressure while standing and the relationship of heart rate with o sub(2 during walking and running were not altered by BWS. While walking, the RPE at a o) sub(2) of 10 mL super(. kg[super]-1 ) super(.) min[super]-1 was statistically lower (P.05) at 0% BWS compared with 25% and 50% BWS (mean values, 7 vs 8 points), but RPE was not different among conditions while running at a o sub(2 of 25 mL ) super(.) kg[super]-1 super(. min[super]-1. Peak normal GRFs at specified o) sub(2) levels and RPE values were reduced (P.05) with increasing BWS for walking and running. Conclusions: Because partial BWS does not alter the relationship of heart rate with o sub(2 during exercise and has minimal effect on the relationship of RPE with o) sub(2), training heart rate and RPE values do not appear to require adjustment with partial BWS. Reduced GRFs at specified o sub(2 levels from partial BWS suggest that there are important clinical applications of this technology.) JF - Archives of Physical Medicine and Rehabilitation AU - Hoffman, Martin D AU - Donaghe, Haylee E AD - Department of Physical Medicine and Rehabilitation, Department of Veterans Affairs, Northern California Health Care System, and University of California Davis Medical Center, Sacramento, CA, martin.hoffman@va.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 960 EP - 966 PB - Elsevier BV, The Curtis Center, Independence Square West Philadelphia PA 19106-3399 USA VL - 92 IS - 6 SN - 0003-9993, 0003-9993 KW - Physical Education Index KW - Adults KW - Heart rate KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1496888694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Physiological+Responses+to+Body+Weight-Supported+Treadmill+Exercise+in+Healthy+Adults&rft.au=Hoffman%2C+Martin+D%3BDonaghe%2C+Haylee+E&rft.aulast=Hoffman&rft.aufirst=Martin&rft.date=2011-06-01&rft.volume=92&rft.issue=6&rft.spage=960&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/10.1016%2Fj.apmr.2010.12.035 LA - English DB - Physical Education Index N1 - Date revised - 2014-02-01 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - Heart rate DO - http://dx.doi.org/10.1016/j.apmr.2010.12.035 ER - TY - JOUR T1 - "I Have to Keep Going": Why Some Older Adults Are Using the Internet for Health Information AN - 1429624588; 201307343 AB - This study used an ethnographic approach to understand why older adults in the United States are using the Internet for health information and how this activity may or may not relate to their ideas about aging. Eight (N=8) older adults were visited in their homes during 4 months. Semi-structured interviewing, informal conversations, and observation techniques were used. Data were thematically coded and analyzed. Findings suggest that older adults' ideas about aging influenced their definitions of health, health information seeking, and what they considered to be health information. They were using the Internet to demonstrate their independence and remain active. "Health" information went beyond the health/disease/illness constructs and incorporated their ideas of aging and how they were using the Internet for information that they hoped would help them maintain their independence. Insight into why older adults are engaging in this electronic form of health information seeking provides an opportunity to understand how effective this form of health communication is currently, and how it can be optimized to design technologically based health information/programs that are applicable and relevant to older adults' lifestyles. This study was limited by the small number of individuals that participated, which limits its generalizability. However, it does demonstrate that broader definitions of health, ones which incorporate notions of aging, may help us better understand the types of information older adults consider to be health information- and how these definitions could potentially influence health information seeking via the Internet. Adapted from the source document. JF - Ageing International AU - Harrod, Molly AD - VA Health Services Research & Development Center of Excellence (152), VA Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI, USA molly.harrod@va.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 283 EP - 294 PB - Springer, New York NY VL - 36 IS - 2 SN - 0163-5158, 0163-5158 KW - Health Problems KW - Aging KW - Ethnography KW - Elderly KW - Health KW - Interviews KW - Telecommunications KW - Internet KW - Lifestyle KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1429624588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ageing+International&rft.atitle=%22I+Have+to+Keep+Going%22%3A+Why+Some+Older+Adults+Are+Using+the+Internet+for+Health+Information&rft.au=Harrod%2C+Molly&rft.aulast=Harrod&rft.aufirst=Molly&rft.date=2011-06-01&rft.volume=36&rft.issue=2&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Ageing+International&rft.issn=01635158&rft_id=info:doi/10.1007%2Fs12126-010-9090-z LA - English DB - Social Services Abstracts N1 - Date revised - 2013-09-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AGINFQ N1 - SubjectsTermNotLitGenreText - Elderly; Health; Internet; Aging; Health Problems; Ethnography; Lifestyle; Interviews; Telecommunications DO - http://dx.doi.org/10.1007/s12126-010-9090-z ER - TY - JOUR T1 - Development of the Listening Self-Efficacy Questionnaire (LSEQ) AN - 1023096877; 201218392 AB - Objective: Listening self-efficacy refers to the beliefs, or confidence, that listeners have in their capability to successfully listen in specific situations, which may influence audiologic rehabilitation outcomes. The objective of this study was to develop and validate the Listening Self-Efficacy Questionnaire (LSEQ), which quantifies listening self-efficacy in a variety of situations where the goal of the listener is to understand speech. Study Sample: Older listeners with hearing loss (N = 169) participated in the study. Design: A factor analysis showed that the LSEQ has three subscales, with beliefs about listening capabilities relating to the following situations: (1) dialogue in quiet, (2) focusing attention on a single source, and (3) complex auditory scenes. Internal consistency reliability was excellent (Chronbach's a > .80). Results: The validity of the LSEQ was demonstrated by comparing the LSEQ scores to audiologic measures, responses on questionnaires, and to the scores for reference groups of younger and older listeners with normal hearing. Conclusion: The findings indicate that the LSEQ is a valid and reliable measure of listening self-efficacy with good potential for use in clinical and research settings. Adapted from the source document. JF - International Journal of Audiology AU - Smith, Sherri L AU - Pichora-Fuller, M Kathleen AU - Watts, Kelly L AU - La More, Carissa Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 417 EP - 425 PB - Informa Healthcare, Taylor and Francis, London UK VL - 50 IS - 6 SN - 1499-2027, 1499-2027 KW - Self-efficacy, Confidence, Age, Speech perception, Hearing loss, Listening in noise, Audiologic rehabilitation, Questionnaire, Self-report KW - Selfefficacy KW - Listening KW - Rehabilitation KW - Listeners KW - Capabilities KW - Hearing KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023096877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=Development+of+the+Listening+Self-Efficacy+Questionnaire+%28LSEQ%29&rft.au=Smith%2C+Sherri+L%3BPichora-Fuller%2C+M+Kathleen%3BWatts%2C+Kelly+L%3BLa+More%2C+Carissa&rft.aulast=Smith&rft.aufirst=Sherri&rft.date=2011-06-01&rft.volume=50&rft.issue=6&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/10.3109%2F14992027.2011.553205 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Listening; Selfefficacy; Listeners; Capabilities; Hearing; Rehabilitation DO - http://dx.doi.org/10.3109/14992027.2011.553205 ER - TY - JOUR T1 - Psychologist suicide: Incidence, impact, and suggestions for prevention, intervention, and postvention AN - 1023094775; 201215726 AB - Psychologist practitioners are not immune to certain mental health problems, including suicidality, for which they provide services. In the aftermath of two recent psychologist suicides, the American Psychological Association's Advisory Committee on Colleague Assistance (ACCA) initiated the formation of a conjoint ad hoc committee consisting of members from ACCA, the American Psychological Association (APA) Practice Directorate, and the Section on Clinical Emergencies and Crises (Section VII of APA's Division 12) to investigate the incidence of psychologist suicide and its impact on colleagues, students or interns, patients or clients, and the profession. The committee reviewed the extant empirical literature on suicide rates for psychologists, evaluated unpublished data on psychologist suicide provided by the National Institute of Occupational Safety and Health (NIOSH), interviewed colleague survivors, reviewed published case reports of the impact of therapist suicides, and linked their findings to the literature on professional distress, impairment, and self-care. The committee concluded that there is evidence suggestive of an elevated risk of suicide for psychologists in past decades. It further concluded that there is a need for further research to confirm if there is a heightened risk of suicide for psychologists in the present day and to determine factors that might contribute to such risk. Accounts from colleague-survivors suggest that the impact of a psychologist's suicide can affect many people including family, colleagues, students, and patients or clients. This article offers suggestions for possible preventive approaches, for intervention with potentially at-risk colleagues, and for postvention efforts in the wake of a colleague suicide. [Copyright Elsevier B.V.] JF - Professional Psychology: Research and Practice AU - Kleespies, Phillip M AU - Van Orden, Kimberly A AU - Bongar, Bruce AU - Bridgeman, Diane AU - Bufka, Lynn F AU - Galper, Daniel I AU - Hillbrand, Marc AU - Yufit, Robert I AD - VA Boston Healthcare System, Psychology Service (116 B phillip.kleespies@va.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 244 EP - 251 PB - American Psychological Association, Washington DC VL - 42 IS - 3 SN - 0735-7028, 0735-7028 KW - colleague assistance KW - colleague suicide KW - impact of psychologist suicide KW - psychologist suicide KW - self-care KW - intervention KW - postvention KW - prevention KW - American Psychological Association KW - Colleagues KW - Psychologists KW - Suicide KW - Advisory committees KW - Clinical psychologists KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023094775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Psychology%3A+Research+and+Practice&rft.atitle=Psychologist+suicide%3A+Incidence%2C+impact%2C+and+suggestions+for+prevention%2C+intervention%2C+and+postvention&rft.au=Kleespies%2C+Phillip+M%3BVan+Orden%2C+Kimberly+A%3BBongar%2C+Bruce%3BBridgeman%2C+Diane%3BBufka%2C+Lynn+F%3BGalper%2C+Daniel+I%3BHillbrand%2C+Marc%3BYufit%2C+Robert+I&rft.aulast=Kleespies&rft.aufirst=Phillip&rft.date=2011-06-01&rft.volume=42&rft.issue=3&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Professional+Psychology%3A+Research+and+Practice&rft.issn=07357028&rft_id=info:doi/10.1037%2Fa0022805 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Suicide; Psychologists; Colleagues; Clinical psychologists; American Psychological Association; Advisory committees DO - http://dx.doi.org/10.1037/a0022805 ER - TY - JOUR T1 - The Nurse Leader as Change Agent and Role Model: Thoughts of a New Nurse Manager AN - 1023092664; 201216446 AB - The concept of leadership is elusive. Is it a behavior, a combination of actions, personal characteristics, tangible and measurable, assumed? Are leaders born? Are leaders made? Can positive change really be made? What drives the thinking behind leadership behavior? Does a more seasoned nurse have more leadership potential or characteristics than a younger, enthusiastic, energetic nurse? With whom do organizational leaders take a chance? Do mentoring and coaching come into play? Are female leaders viewed as less competent than male? All these and many more questions are quite interesting to ponder. [Copyright Elsevier B.V.] JF - Nurse Leader AU - Maragh, Kathy A Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 39 EP - 42 PB - Elsevier Ltd, The Netherlands VL - 9 IS - 3 SN - 1541-4612, 1541-4612 KW - Change agents KW - Coaching KW - Nurse managers KW - Mentoring KW - Leaders KW - Leadership KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023092664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nurse+Leader&rft.atitle=The+Nurse+Leader+as+Change+Agent+and+Role+Model%3A+Thoughts+of+a+New+Nurse+Manager&rft.au=Maragh%2C+Kathy+A&rft.aulast=Maragh&rft.aufirst=Kathy&rft.date=2011-06-01&rft.volume=9&rft.issue=3&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Nurse+Leader&rft.issn=15414612&rft_id=info:doi/10.1016%2Fj.mnl.2010.09.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Leaders; Leadership; Nurse managers; Mentoring; Coaching; Change agents DO - http://dx.doi.org/10.1016/j.mnl.2010.09.007 ER - TY - JOUR T1 - Anterior cingulate volume reduction in adolescents with borderline personality disorder and co-morbid major depression AN - 1010708708; 201208395 AB - Borderline Personality Disorder (BPD) is a serious illness characterized by emotional dysregulation, impulsivity, and impaired interpersonal relationships. Prior work shows the anterior cingulate gyrus (ACG) -- a region primarily involved in assessing the salience of emotional information and regulating emotional responses--is smaller in adults with BPD. We tested the hypothesis that, similar to adults, adolescents with BPD would have reduced Brodmann area (BA)-24 volume. Thirteen adolescent inpatients with co-morbid BPD and Major Depressive Disorder (MDD) and 13 matched healthy controls received 3T-MRI scans. Using a cytoarchitecturally-derived approach measuring gray and white matter volume, we observed a Group x Cingulate BA (25,24,31,23,29) x Matter (gray, white) type interaction indicating the BPD/MDD adolescents had smaller BA24 volume in gray but not white matter. Greater number of suicide attempts and BPD symptom severity measured by the Diagnostic Interview for BPD-revised (DIB-R) total score but not depressive symptoms measured by the Beck Depression Inventory (BDI) was associated with smaller BA24 volume. Our preliminary findings suggest that BPD-related abnormalities in BA24 volume may occur early in the developmental course of BPD with MDD. Future studies examining samples of MDD patients with and without BPD co-morbidity will be needed to clarify whether BA24 volume reductions are specific to BPD. [Copyright Elsevier Ltd.] JF - Journal of Psychiatric Research AU - Goodman, Marianne AU - Hazlett, Erin A AU - Avedon, Jennifer B AU - Siever, Daniel R AU - Chu, King-Wai AU - New, Antonia S AD - Department of Psychiatry, Mount Sinai School of Medicine, New York, USA Marianne.goodman@va.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 803 EP - 807 PB - Elsevier Ltd, Oxford UK VL - 45 IS - 6 SN - 0022-3956, 0022-3956 KW - Borderline personality disorder KW - Adolescent KW - Structural neuroimaging KW - MRI, anterior cingulate KW - Major depression KW - Depressive personality disorders KW - Depression KW - Impulsivity KW - Comorbidity KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010708708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychiatric+Research&rft.atitle=Anterior+cingulate+volume+reduction+in+adolescents+with+borderline+personality+disorder+and+co-morbid+major+depression&rft.au=Goodman%2C+Marianne%3BHazlett%2C+Erin+A%3BAvedon%2C+Jennifer+B%3BSiever%2C+Daniel+R%3BChu%2C+King-Wai%3BNew%2C+Antonia+S&rft.aulast=Goodman&rft.aufirst=Marianne&rft.date=2011-06-01&rft.volume=45&rft.issue=6&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychiatric+Research&rft.issn=00223956&rft_id=info:doi/10.1016%2Fj.jpsychires.2010.11.011 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JPYRA3 N1 - SubjectsTermNotLitGenreText - Borderline personality disorder; Depressive personality disorders; Adolescents; Comorbidity; Depression; Impulsivity DO - http://dx.doi.org/10.1016/j.jpsychires.2010.11.011 ER - TY - JOUR T1 - A statistical model of horizontal auditory localization performance data AN - 1010702902; 201204027 AB - Horizontal localization experiments are used to evaluate the listener's ability to locate the position of a sound source, and determine how signal characteristics affect this ability. These experiments generate circular, bimodal, and repeated data that are challenging to statistically analyze. A two-part mixture of wrapped Cauchys is proposed for these data, with the effects of signal type and position on localization bias, precision, and front-back confusion modeled using regression. The model is illustrated using mid- (1.0-2.0 kHz) and high- (3.0-6.0 kHz) frequency narrow band noises localization collected among ten normal hearing listeners. [Copyright Acoustical Society of America.] JF - The Journal of the Acoustical Society of America AU - McMillan, Garnett P AU - Saunders, Gabrielle AU - Hanson, Timothy E AD - National Center for Rehabilitative Auditory Research, Veterans Affairs Medical Center garnett.mcmillan@va.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - EL229 EP - EL235 VL - 129 IS - 6 SN - 0001-4966, 0001-4966 KW - Speech Perception (82700) KW - Auditory Localization (05700) KW - article KW - 4017: psycholinguistics; psychoacoustics/speech perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010702902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=A+statistical+model+of+horizontal+auditory+localization+performance+data&rft.au=McMillan%2C+Garnett+P%3BSaunders%2C+Gabrielle%3BHanson%2C+Timothy+E&rft.aulast=McMillan&rft.aufirst=Garnett&rft.date=2011-06-01&rft.volume=129&rft.issue=6&rft.spage=EL229&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JASMAN N1 - SubjectsTermNotLitGenreText - Auditory Localization (05700); Speech Perception (82700) ER - TY - JOUR T1 - Treatment of Department of Veterans Affairs Primary Care Patients With Posttraumatic Stress Disorder AN - 881450593; 201114880 AB - Posttraumatic stress disorder (PTSD) is common among Veterans Affairs (VA) primary care patients and may be managed via multiple treatment pathways. Using the Behavioral Model of Health Service Use (Anderson, 1995), this retrospective study based on medical chart review examined factors associated with three types of mental health treatment: intervention by a 1) primary care provider (PCP), 2) primary care-mental health integration (PC-MHI) provider, and 3) specialty mental health (SMH) provider. A second goal was to describe PTSD treatment services for patients not receiving SMH by detailing the content of mental health treatment provided by PCPs and PC-MHI providers. Electronic medical record data for a five year time period for 133 Veterans were randomly selected for review from a population 6,637 primary care patients with PTSD. Results indicated that the evaluated needs of participants (i.e., number of unique medical and psychiatric disorders) were associated with Veterans receiving more intensive services (i.e., SMH). PCPs commonly addressed patients' mental health concerns, but patients often declined referrals for mental health treatment. PC-MHI consultations most often focused on medication management and supportive psychotherapy. [Copyright Elsevier B.V.] JF - Psychological Services AU - Possemato, Kyle AU - Ouimette, Paige AU - Lantinga, Larry J AU - Wade, Michael AU - Coolhart, Deb AU - Schohn, Mary AU - Labbe, Allison AU - Strutynski, Kate AD - Center for Integrated Healthcare, VA Healthcare Network Upstate New York kyle.possemato@va.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 82 EP - 93 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 8 IS - 2 SN - 1541-1559, 1541-1559 KW - posttraumatic stress disorder primary care health care utilization primary care-mental health integration KW - Supportive psychotherapy KW - Veterans KW - Posttraumatic stress disorder KW - Mental health services KW - Integrated services KW - Primary health care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881450593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Treatment+of+Department+of+Veterans+Affairs+Primary+Care+Patients+With+Posttraumatic+Stress+Disorder&rft.au=Possemato%2C+Kyle%3BOuimette%2C+Paige%3BLantinga%2C+Larry+J%3BWade%2C+Michael%3BCoolhart%2C+Deb%3BSchohn%2C+Mary%3BLabbe%2C+Allison%3BStrutynski%2C+Kate&rft.aulast=Possemato&rft.aufirst=Kyle&rft.date=2011-05-01&rft.volume=8&rft.issue=2&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0022704 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Mental health services; Posttraumatic stress disorder; Veterans; Primary health care; Integrated services; Supportive psychotherapy DO - http://dx.doi.org/10.1037/a0022704 ER - TY - JOUR T1 - Tuberculosis at the human-animal interface: An emerging disease of elephants AN - 874185127; 14977271 AB - Over the past 15 years, cases of infection with organisms of the Mycobacterium tuberculosis complex have been diagnosed among captive elephants in the United States and worldwide. Outbreak investigations have documented that among staff employed at facilities housing infected animals, skin test conversion to purified protein derivative have been documented. Clonal spread among animals in close contact and even inter-species spread between elephant and human has been documented. Detection of actively infected animals relies on samples obtained by trunk wash. Diagnosis has been augmented by the development of a multi-antigen serologic assay with excellent specificity and sensitivity. Treatment regimens are still in development with efficacy largely unknown due to a paucity of both premortem follow-up and necropsy data of treated animals. The epidemiology, diagnosis and treatment of tuberculosis in elephants require additional careful study of clinical data. JF - Tuberculosis AU - Mikota, Susan K AU - Maslow, Joel N AD - Elephant Care International, Hohenwald, TN, United States, joel.maslow@va.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 208 EP - 211 PB - Harcourt Publishers Ltd., Robert Stevenson House Edinburgh EH1 3AF UK VL - 91 IS - 3 SN - 1472-9792, 1472-9792 KW - Microbiology Abstracts B: Bacteriology KW - Autopsy KW - Data processing KW - Housing KW - Epidemiology KW - Elephantidae KW - Tuberculosis KW - Tuberculin KW - Infection KW - Mycobacterium tuberculosis KW - Skin tests KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874185127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tuberculosis&rft.atitle=Tuberculosis+at+the+human-animal+interface%3A+An+emerging+disease+of+elephants&rft.au=Mikota%2C+Susan+K%3BMaslow%2C+Joel+N&rft.aulast=Mikota&rft.aufirst=Susan&rft.date=2011-05-01&rft.volume=91&rft.issue=3&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Tuberculosis&rft.issn=14729792&rft_id=info:doi/10.1016%2Fj.tube.2011.02.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Autopsy; Data processing; Epidemiology; Housing; Tuberculin; Tuberculosis; Infection; Skin tests; Elephantidae; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1016/j.tube.2011.02.007 ER - TY - JOUR T1 - Aging disaster: mortality, vulnerability, and long-term recovery among Katrina survivors AN - 870435876; 4201756 AB - Data from this multiyear qualitative study of the effects of Hurricane Katrina and flooding in New Orleans suggest differences in how the elderly cope with disaster. At the time of the disaster, the elderly of New Orleans were at greater risk than other groups, and more elderly died than any other group during the storm and in the first year after. Those who did survive beyond the first year report coping with the long-term disaster aftermath better than the generation below them, experiencing heightened stresses, and feeling as if they are aging faster than they should. We offer insight on how we might define and characterize disasters, and illustrate that long-term catastrophes age in specific ways. Reprinted by permission of Harwood Academic Publishers, Taylor and Francis Ltd JF - Medical anthropology AU - Adams, Vincanne AU - Kaufman, Sharon AU - Hattum, Taslim van AU - Moody, Sandra AD - University of California, San Francisco ; San Francisco Veterans Administration Medical Center Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 247 EP - 270 VL - 30 IS - 3 SN - 0145-9740, 0145-9740 KW - Anthropology KW - Vulnerability KW - Qualitative analysis KW - Ageing KW - Mortality KW - Floods KW - Survival strategy KW - Disasters KW - Old age KW - Louisiana UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870435876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+anthropology&rft.atitle=Aging+disaster%3A+mortality%2C+vulnerability%2C+and+long-term+recovery+among+Katrina+survivors&rft.au=Adams%2C+Vincanne%3BKaufman%2C+Sharon%3BHattum%2C+Taslim+van%3BMoody%2C+Sandra&rft.aulast=Adams&rft.aufirst=Vincanne&rft.date=2011-05-01&rft.volume=30&rft.issue=3&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Medical+anthropology&rft.issn=01459740&rft_id=info:doi/10.1080%2F01459740.2011.560777 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 655; 3601; 8291 3409 6306; 12432; 10519 3279 971 3286; 5068 8559 3601; 8911 602 652 5676 646 6091; 220 433 293 14 DO - http://dx.doi.org/10.1080/01459740.2011.560777 ER - TY - JOUR T1 - Outpatient Management of the Elderly Patient Following Fragility Hip Fracture AN - 869581410; 14819598 AB - Hip fractures associated with underlying osteoporosis result in significant morbidity and mortality in elderly patients and increase the risk for future fractures. Several underlying modifiable contributors may be identified, while osteoporosis itself is amenable to a number of effective treatments. Other interventions can further reduce the risk of falls and second fractures. This paper reviews evaluation and management options after fragility (low trauma) hip fractures in the geriatric population. JF - American Journal of Medicine AU - Sanders, Suzanne AU - Geraci, Stephen A AD - Division of Rheumatology, Department of Medicine, University of Mississippi School of Medicine, Jackson, Miss, Suzanne.Sanders@va.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 408 EP - 410 PB - Elsevier BV, PO Box 10670 Riverton, NJ 08076 USA VL - 124 IS - 5 SN - 0002-9343, 0002-9343 KW - Risk Abstracts KW - Mortality KW - Morbidity KW - risk reduction KW - hip fracture KW - osteoporosis KW - Reviews KW - intervention KW - elderly KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869581410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Medicine&rft.atitle=Outpatient+Management+of+the+Elderly+Patient+Following+Fragility+Hip+Fracture&rft.au=Sanders%2C+Suzanne%3BGeraci%2C+Stephen+A&rft.aulast=Sanders&rft.aufirst=Suzanne&rft.date=2011-05-01&rft.volume=124&rft.issue=5&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Medicine&rft.issn=00029343&rft_id=info:doi/10.1016%2Fj.amjmed.2010.06.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; risk reduction; hip fracture; osteoporosis; intervention; Reviews; elderly; Morbidity DO - http://dx.doi.org/10.1016/j.amjmed.2010.06.028 ER - TY - JOUR T1 - Assessment of Measures for Abdominal Adiposity in Persons with Spinal Cord Injury AN - 867741556; 14768292 AB - Ultrasound may be a useful tool to assess abdominal adiposity, but it has not been validated in the spinal cord injury (SCI) population. This study evaluated associations between abdominal ultrasound and other methods to assess adiposity in 24 men with SCI and 20 able-bodied (AB) men. Waist (WC) and hip circumference (HC) and waist-to-hip ratio (WHR) were measured. Trunk (TRK%), android (A%) and waist fat (W%) were determined by dual energy x-ray absorptiometry (DXA); ultrasonography determined abdominal subcutaneous (SF) and visceral fat (VF). The SCI group had greater TRK% (40.0 +/- 9.6 vs. 32.0 +/- 10.3), W% (47.0 +/- 9.7 vs. 40.6 +/- 9.4), A% (43.0 +/- 9.8 vs. 35.8 +/- 10.6) and WHR (0.99 +/- 0.1 vs. 0.92 +/- 0.06) than the AB group. WC and WHR correlated with VF in the SCI group. These associations suggest that ultrasound may be a useful tool in clinical practice for the measurement of VF in weight loss programs and for the assessment of cardiometabolic disorders. (E-mail: racine.emmonsa.gov) JF - Ultrasound in Medicine & Biology AU - Emmons, Racine R AU - Garber, Carol Ewing AU - Cirnigliaro, Christopher M AU - Kirshblum, Steven C AU - Spungen, Ann M AU - Bauman, William A Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 734 EP - 741 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 37 IS - 5 SN - 0301-5629, 0301-5629 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Adipose tissue KW - Antibodies KW - Dual energy X-ray absorptiometry KW - Hip KW - Methyltestosterone KW - Spinal cord injury KW - Ultrasonography KW - Ultrasound KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867741556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Medicine+%26+Biology&rft.atitle=Assessment+of+Measures+for+Abdominal+Adiposity+in+Persons+with+Spinal+Cord+Injury&rft.au=Emmons%2C+Racine+R%3BGarber%2C+Carol+Ewing%3BCirnigliaro%2C+Christopher+M%3BKirshblum%2C+Steven+C%3BSpungen%2C+Ann+M%3BBauman%2C+William+A&rft.aulast=Emmons&rft.aufirst=Racine&rft.date=2011-05-01&rft.volume=37&rft.issue=5&rft.spage=734&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Medicine+%26+Biology&rft.issn=03015629&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2011.02.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-06-29 N1 - SubjectsTermNotLitGenreText - Antibodies; Dual energy X-ray absorptiometry; Adipose tissue; Methyltestosterone; Spinal cord injury; Ultrasonography; Ultrasound; Hip DO - http://dx.doi.org/10.1016/j.ultrasmedbio.2011.02.002 ER - TY - JOUR T1 - Assault Rates and Implementation of a Workplace Violence Prevention Program in the Veterans Health Care Administration AN - 1020837193; 14930896 AB - Objective: This study examined the relationship between changes in assault rates over time and the implementation of a workplace violence prevention (WVP) program in 138 Department of Veterans Affairs health care facilities. Methods: Data on WVP implementation were assessed for each facility by a three-person team. We computed three WVP dimension scores: training, workplace practices, and environmental control and security. We obtained 6 years of assault rate data from the national injury system. Using a linear mixed model, we analyzed whether the WVP implementation was associated with lower assault rates controlling for time and organizational characteristics. Results: Training implementation was negatively associated with assault rates. Facilities with smaller bed sizes and without academic affiliates had lower assault rates. Conclusions: Particular attention should be given to these dimensions because they may be associated with lower facility-level assault rates. JF - Journal of Occupational and Environmental Medicine AU - Mohr, D C AU - Warren, N AU - Hodgson, MJ AU - Drummond, D J AD - VA Boston Healthcare System (152M), 150 South Huntington Ave, Boston, MA 02130, USA, david.mohr2@va.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 511 EP - 516 VL - 53 IS - 5 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Health care KW - Injuries KW - Prevention KW - Security KW - Training KW - Violence KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020837193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Assault+Rates+and+Implementation+of+a+Workplace+Violence+Prevention+Program+in+the+Veterans+Health+Care+Administration&rft.au=Mohr%2C+D+C%3BWarren%2C+N%3BHodgson%2C+MJ%3BDrummond%2C+D+J&rft.aulast=Mohr&rft.aufirst=D&rft.date=2011-05-01&rft.volume=53&rft.issue=5&rft.spage=511&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31820d101e LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Security; Prevention; Injuries; Health care; Training; Violence DO - http://dx.doi.org/10.1097/JOM.0b013e31820d101e ER - TY - JOUR T1 - Combination treatment to CONQUER obesity? AN - 867739353; 14770925 JF - Lancet AU - Shah, Krupa AU - Villareal, Dennis T AD - Division of Geriatrics and Aging, University of Rochester School of Medicine and Dentistry, Highland Hospital, Rochester, NY, USA, dennis.villareal@va.gov Y1 - 2011/04/22/ PY - 2011 DA - 2011 Apr 22 SP - 1295 EP - 1297 PB - The Lancet Ltd., 655 Ave. of the Americas New York NY 10011 USA VL - 377 IS - 9774 SN - 0140-6736, 0140-6736 KW - Health & Safety Science Abstracts KW - obesity KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867739353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Combination+treatment+to+CONQUER+obesity%3F&rft.au=Shah%2C+Krupa%3BVillareal%2C+Dennis+T&rft.aulast=Shah&rft.aufirst=Krupa&rft.date=2011-04-22&rft.volume=377&rft.issue=9774&rft.spage=1295&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2811%2960518-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2013-02-08 N1 - SubjectsTermNotLitGenreText - obesity DO - http://dx.doi.org/10.1016/S0140-6736(11)60518-7 ER - TY - JOUR T1 - Emergence of Linezolid-Resistant Staphylococcus aureus after Prolonged Treatment of Cystic Fibrosis Patients in Cleveland, Ohio AN - 911167597; 16062504 AB - Linezolid (LZD)-resistant Staphylococcus aureus (LRSA) isolates were monitored from 2000 to 2009 in Cleveland, OH. LRSA first emerged in 2004 only in cystic fibrosis (CF) patients, with 11 LRSA-infected CF patients being identified by 2009. LRSA was isolated from 8 of 77 CF patients with S. aureus respiratory tract infection treated with LZD from 2000 to 2006. Analysis of clinical data showed that the 8 CF patients with LRSA received more LZD courses (18.8 versus 5.9; P = 0.001) for a longer duration (546.5 versus 211.9 days; P < 0.001) and had extended periods of exposure to LZD (83.1 versus 30.1 days/year; P < 0.001) than the 69 with LZD-susceptible isolates. Five LRSA isolates included in the clinical analysis (2000 to 2006) and three collected in 2009 were available for molecular studies. Genotyping by repetitive extrapalindromic PCR and pulsed-field gel electrophoresis revealed that seven of these eight LRSA strains from unique patients were genetically similar. By multilocus sequence typing, all LRSA isolates were included in clonal complex 5 (seven of sequence type 5 [ST5] and one of ST1788, a new single-locus variant of ST5). However, seven different variants were identified by spa typing. According to the Escherichia coli numbering system, seven LRSA isolates contained a G2576T mutation (G2603T, S. aureus numbering) in one to four of the five copies of domain V of the 23S rRNA genes. One strain also contained a mutation (C2461T, E. coli numbering) not previously reported. Two strains, including one without domain V mutations, possessed single amino acid substitutions (Gly152Asp or Gly139Arg) in the ribosomal protein L3 of the peptidyltransferase center, substitutions not previously reported in clinical isolates. Emergence of LRSA is a serious concern for CF patients who undergo prolonged courses of LZD therapy. JF - Antimicrobial Agents & Chemotherapy AU - Endimiani, Andrea AU - Blackford, Martha AU - Dasenbrook, Elliot C AU - Reed, Michael D AU - Bajaksouszian, Saralee AU - Hujer, Andrea M AU - Rudin, Susan D AU - Hujer, Kristine M AU - Perreten, Vincent AU - Rice, Louis B AD - Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, robert.bonomo@va.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 1684 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 55 IS - 4 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clinical isolates KW - Data processing KW - Amino acid substitution KW - rRNA 23S KW - Genotyping KW - Infection KW - multilocus sequence typing KW - Respiratory tract diseases KW - rRNA KW - Escherichia coli KW - Pulsed-field gel electrophoresis KW - Peptidyltransferase KW - ribosomal protein L3 KW - Polymerase chain reaction KW - Staphylococcus aureus KW - Cystic fibrosis KW - Mutation KW - Linezolid KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911167597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Emergence+of+Linezolid-Resistant+Staphylococcus+aureus+after+Prolonged+Treatment+of+Cystic+Fibrosis+Patients+in+Cleveland%2C+Ohio&rft.au=Endimiani%2C+Andrea%3BBlackford%2C+Martha%3BDasenbrook%2C+Elliot+C%3BReed%2C+Michael+D%3BBajaksouszian%2C+Saralee%3BHujer%2C+Andrea+M%3BRudin%2C+Susan+D%3BHujer%2C+Kristine+M%3BPerreten%2C+Vincent%3BRice%2C+Louis+B&rft.aulast=Endimiani&rft.aufirst=Andrea&rft.date=2011-04-01&rft.volume=55&rft.issue=4&rft.spage=1684&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01308-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Amino acid substitution; Data processing; rRNA 23S; Genotyping; Infection; multilocus sequence typing; rRNA; Respiratory tract diseases; ribosomal protein L3; Peptidyltransferase; Pulsed-field gel electrophoresis; Polymerase chain reaction; Linezolid; Mutation; Cystic fibrosis; Escherichia coli; Staphylococcus aureus DO - http://dx.doi.org/10.1128/AAC.01308-10 ER - TY - JOUR T1 - Clostridium difficile enteritis: A review and pooled analysis of the cases AN - 907159003; 14961980 AB - Clostridium difficile is the most common cause of healthcare-associated infection diarrhea and usually restricted to infection of the colon. However, small bowel involvement of C. difficile infection has been reported. We performed a literature review and pooled analysis of the reported cases of C. difficile enteritis Method: A Pubmed literature database search and pooled analysis of the reported cases of C. difficile enteritis. Results: 56 cases of C. difficile enteritis have been reported from 1980 to 2010; 48 cases were published since 2001. Median age was 55 years. 27 patients (48.2%) were female. 29 patients (51.8%) had inflammatory bowel disease (IBD) - Crohn's disease or ulcerative colitis and 20 patients (35.7%) had predisposing medical condition(s) that might lead to an immunoincompetent state. 33 patients (58.9%) had colectomy with ileostomy and 13 patients (23.2%) had other small and/or large bowel surgery. Thirty four patients (60.7%) received ICU management and 18 patients (32.1%) died. We categorized the patients into two groups, 38 survivors (67.9%) 18 non-survivors (32.1%). Significantly older age was noted in non-survivors. Median age was 48 years and 66 years, respectively for survivors and non-survivors, P 0.001. There were more patients with predisposing medical condition(s) among non-survivors, (13/18, 72.2%) than among survivors (7/38, 18.4%), P 0.001. Conclusions: C. difficile enteritis is still rare, however it seems to be increasingly reported in recent years. Surgically altered intestinal anatomies, advanced age, predisposing medical condition(s) that might lead to immunoincompetence appear to be at risk for developing C. difficile enteritis. Recognition of C. difficile infection not only in the colon but also in the small bowel may lead to improved outcomes. JF - Anaerobe AU - Kim, J H AU - Muder, R R AD - Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA, robert.muder@va.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 52 EP - 55 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 17 IS - 2 SN - 1075-9964, 1075-9964 KW - Microbiology Abstracts B: Bacteriology KW - Crohn's disease KW - Age KW - Diarrhea KW - Ulcerative colitis KW - Enteritis KW - Infection KW - Databases KW - Inflammatory bowel diseases KW - Colon KW - Surgery KW - Geriatrics KW - Intestine KW - Ileostomy KW - Clostridium difficile KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907159003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Clostridium+difficile+enteritis%3A+A+review+and+pooled+analysis+of+the+cases&rft.au=Kim%2C+J+H%3BMuder%2C+R+R&rft.aulast=Kim&rft.aufirst=J&rft.date=2011-04-01&rft.volume=17&rft.issue=2&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=10759964&rft_id=info:doi/10.1016%2Fj.anaerobe.2011.02.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Crohn's disease; Age; Diarrhea; Enteritis; Ulcerative colitis; Infection; Databases; Colon; Inflammatory bowel diseases; Surgery; Intestine; Geriatrics; Ileostomy; Clostridium difficile DO - http://dx.doi.org/10.1016/j.anaerobe.2011.02.002 ER - TY - JOUR T1 - Improving the Long-Term Care Referral Process: Insights From Patients and Caregivers AN - 902081321; 201104624 AB - Large increases in the need for long-term care (LTC) services are expected as baby boomers age. Little has been published about patient and caregiver preferences for information about LTC. However, our qualitative research findings suggest that potential consumers may find it difficult to obtain accurate and timely information about LTC programs and services. In-person, semistructured interviews were conducted with 47subjects, including patients (n = 25) within 90 days of their referral to a LTC placement (including NH, assisted living, home care, and community) and their caregivers (n = 22). Interview questions addressed the events that seemed to trigger their need for a LTC referral, the resources they used to become more informed about LTC options and the issues they confronted with the LTC referral process. Qualitative analyses identified a number of patient and informal caregiver-reported barriers to making decisions about LTC services, including insufficient information about LTC programs and community resources, unclear funding requirements and inadequate funding, and difficulty knowing how to plan for LTC or make LTC decisions. A potential solution may be an online LTC Guide designed to provide accurate information about the range of LTC services, with an emphasis on home and community-based services. This Guide was developed to address the gap in comprehensive LTC information ident/1ed in the findings of this study. Adapted from the source document. JF - Gerontology & Geriatrics Education AU - Guihan, Marylou AU - Hedrick, Susan AU - Miller, Sara AU - Reder, Sheri AD - Center for Management of Complex Chronic Care (CMC3), Edward Hines, Jr. VA Hospital (151-H), 5000 S. 5th Avenue, Hines, IL 60141-3030, USA marylou.guihan@va.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 135 EP - 151 PB - Taylor & Francis, Philadelphia PA VL - 32 IS - 2 SN - 0270-1960, 0270-1960 KW - long-term care, referrals, decision regarding placement KW - Caregivers KW - Constraints KW - Home Health Care KW - Long Term Care KW - Consumers KW - Patients KW - Decision Making KW - Placement KW - Internet KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902081321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gerontology+%26+Geriatrics+Education&rft.atitle=Improving+the+Long-Term+Care+Referral+Process%3A+Insights+From+Patients+and+Caregivers&rft.au=Guihan%2C+Marylou%3BHedrick%2C+Susan%3BMiller%2C+Sara%3BReder%2C+Sheri&rft.aulast=Guihan&rft.aufirst=Marylou&rft.date=2011-04-01&rft.volume=32&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Gerontology+%26+Geriatrics+Education&rft.issn=02701960&rft_id=info:doi/10.1080%2F02701960.2011.572041 LA - English DB - Social Services Abstracts N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-28 N1 - CODEN - GGEDD6 N1 - SubjectsTermNotLitGenreText - Caregivers; Patients; Long Term Care; Decision Making; Home Health Care; Internet; Placement; Consumers; Constraints DO - http://dx.doi.org/10.1080/02701960.2011.572041 ER - TY - JOUR T1 - Daily activities and sleep quality in young adults. AN - 900616114; pmid-21667753 AB - Daily activity levels were investigated as related to sleep quality in young adult college students aged 18 to 30 years. 85 participants (20 men, 65 women) completed the Young Adult Daily Activity Scale (YADAS). This 37-item checklist has 34 items based on focus group discussion points of college students' typical daily activities and three blank items for students to include their daily activities if not in the listing. The tabulation of type and amount of waking daily activities represents a unique measurement of factors that may affect sleep quality. The participants also rated their typical sleep quality using a standard 5-point scale (low indicating poor sleep). Correlations of sleep ratings and activities were not significant. JF - Perceptual and motor skills AU - Sexton-Radek, Kathy AU - Pichler-Mowry, Rene AD - Elmhurst College/Suburban Pulmonary & Sleep Associates Hines Veterans Administration, IL 60126, USA. kathysr@elmhurst.edu Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 426 EP - 428 VL - 112 IS - 2 SN - 0031-5125, 0031-5125 KW - Index Medicus KW - National Library of Medicine KW - *Activities of Daily Living: psychology KW - Adolescent KW - Adult KW - Arousal KW - *Attitude to Health KW - *Circadian Rhythm KW - Female KW - Humans KW - Leisure Activities KW - Male KW - *Sleep KW - Sleep Deprivation KW - Young Adult UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900616114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+motor+skills&rft.atitle=Daily+activities+and+sleep+quality+in+young+adults.&rft.au=Sexton-Radek%2C+Kathy%3BPichler-Mowry%2C+Rene&rft.aulast=Sexton-Radek&rft.aufirst=Kathy&rft.date=2011-04-01&rft.volume=112&rft.issue=2&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+motor+skills&rft.issn=00315125&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Challenges in the design and conduct of controlled clinical effectiveness trials in schizophrenia AN - 883017890; 15274225 AB - Background The introduction of antipsychotic medication has been a major advance in the treatment of schizophrenia and allows millions of people to live outside of institutions. It is generally believed that long-acting intramuscular antipsychotic medication is the most effective approach to increasing medication adherence and thereby reduce relapse in high-risk patients with schizophrenia, but the data are scant.Purpose To report the design of a study to assess the effect of long-acting injectable risperidone in unstable patients and under more realistic conditions than previously studied and to evaluate the effect of this medication on psychiatric inpatient hospitalization, schizophrenia symptoms, quality of life, medication adherence, side effects, and health care costs.Methods The trial was an open randomized clinical comparative effectiveness trial in patients with schizophrenia or schizo-affective disorders in which parenteral risperidone was compared to an oral antipsychotic regimen selected by each control patient's psychiatrist. Participants had unstable psychiatric disease defined by recent hospitalization or exhibition of unusual need for psychiatric services. The primary endpoint was hospitalization for psychiatric indications; the secondary endpoint was psychiatric symptoms.Results Overall, 382 patients were randomized. Determination of a persons' competency to understand the elements of informed consent was addressed. The use of a closed-circuit TV interview for psychosocial measures provided an economical, high quality, reliable means of collecting data. A unique method for insuring that usual care was optimal was incorporated in the follow-up of all subjects.Limitations Patients with schizophrenia or schizo-affective disorders and with the common co-morbid illnesses seen in the VA are a challenging group of subjects to study in long-term trials. Some techniques unique in the VA and found useful may not be generalizable or applicable in other research or treatment settings.Conclusions The trial tested a new antipsychotic medication early in its adoption in the Veterans Health Administration. The VA has a unique electronic medical record and database which can be used to identify the endpoint, that is, first hospitalization due to a psychiatric problem, with complete ascertainment. Several methodologic solutions addressed competency to understand elements of consent, the costs and reliability of collecting interview data gathering, and insuring usual care. JF - Clinical Trials AU - Rosenheck, Robert A AU - Krystal, John H AU - Lew, Robert AU - Barnett, Paul G AU - Thwin, Soe Soe AU - Fiore, Louis AU - Valley, Danielle AU - Huang, Grant D AU - Neal, Carla AU - Vertrees, Julia E AU - Liang, Matthew H AD - Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) Cooperative Studies Program Coordinating Center (CSPCC), Boston, MA, USA, Robert.Rosenheck@va.gov Robert.Rosenheck@va.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 196 EP - 204 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 8 IS - 2 SN - 1740-7745, 1740-7745 KW - CSA Neurosciences Abstracts; Risk Abstracts KW - Data processing KW - Risperidone KW - Adoption KW - clinical trials KW - Clinical trials KW - Design KW - Schizophrenia KW - Databases KW - Mental disorders KW - Health care KW - Neuroleptics KW - Economics KW - Risk groups KW - quality of life KW - Drugs KW - mental disorders KW - Side effects KW - electronic medical records KW - Quality of life KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883017890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Challenges+in+the+design+and+conduct+of+controlled+clinical+effectiveness+trials+in+schizophrenia&rft.au=Rosenheck%2C+Robert+A%3BKrystal%2C+John+H%3BLew%2C+Robert%3BBarnett%2C+Paul+G%3BThwin%2C+Soe+Soe%3BFiore%2C+Louis%3BValley%2C+Danielle%3BHuang%2C+Grant+D%3BNeal%2C+Carla%3BVertrees%2C+Julia+E%3BLiang%2C+Matthew+H&rft.aulast=Rosenheck&rft.aufirst=Robert&rft.date=2011-04-01&rft.volume=8&rft.issue=2&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/10.1177%2F1740774510392931 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Number of references - 45 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Databases; Mental disorders; Data processing; Neuroleptics; Risperidone; Risk groups; Adoption; Clinical trials; electronic medical records; Side effects; Quality of life; Health care; Economics; quality of life; clinical trials; mental disorders; Drugs; Design DO - http://dx.doi.org/10.1177/1740774510392931 ER - TY - JOUR T1 - Patient resistance as agency in treatment decisions AN - 876226367; 14880501 AB - Medication is critical to the management of medical problems, however relatively little attention has been paid to the treatment recommendation process where a new medication is first prescribed. This article argues that how and when a patient agrees to a physicianas treatment demonstrates a patientas active involvement in decisions about treatment. Using 100 video recorded primary care visits across 10 internal medicine clinics in the Western United States, this paper uses conversation analysis to document the delivery and reception of treatment recommendations in acute medical visits with adult patients. Specifically, this article analyzes patients demonstrating active participation regarding treatment decisions as a limited form of agency. Starting from the premise that participants orient to physiciansa treatment recommendations as normatively requiring patient acceptance before moving to a next activity, this article argues that when patients resist a recommendation, they actively participate in how the treatment recommendation emerges as acceptable. This article argues that through resistance to a treatment recommendation, patients work to negotiate and collaboratively co-construct what counts as an acceptable recommendation. Overall, this article argues that patient resistance is an interactional resource for patients to assert their agency by ensuring the ensuing recommendation is acceptable and in accord with their treatment preferences and concerns. JF - Social Science and Medicine AU - Koenig, Christopher J AD - San Francisco Veterans Administration and University of California, San Francisco, 4150 Clement Street, 116P, San Francisco, CA 94121, United States, Christopher.Koenig@ucsf.edu Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 1105 EP - 1114 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 72 IS - 7 SN - 0277-9536, 0277-9536 KW - Sustainability Science Abstracts KW - USA KW - Drugs KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876226367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+and+Medicine&rft.atitle=Patient+resistance+as+agency+in+treatment+decisions&rft.au=Koenig%2C+Christopher+J&rft.aulast=Koenig&rft.aufirst=Christopher&rft.date=2011-04-01&rft.volume=72&rft.issue=7&rft.spage=1105&rft.isbn=&rft.btitle=&rft.title=Social+Science+and+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2011.02.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Drugs; USA DO - http://dx.doi.org/10.1016/j.socscimed.2011.02.010 ER - TY - JOUR T1 - Predicting In-Home Respite Utilization by Family Caregivers of Older Adults: Results of a Community Study AN - 875713337; 201113265 AB - This longitudinal study applies the behavioral model of health services use (Andersen, 1995) to the prediction of in-home respite utilization within the naturalistic context of ongoing respite services. Participants (N = 74) were family caregivers who provided informal care for a physically and/or cognitively impaired older adult All participants resided in the Midwest and received in-home respite services managed by an Area Agency on Aging and funded through the National Family Caregiver Support Program. The primary significant predictor of 3-month in-home respite utilization was the caregiving dyad's past in-home respite usage. Contrary to prior research, demographic predisposing variables (relationship type, household income) and objective need variables (behavioral dysfunction, functional impairment) were not associated with hours of respite use over 3 months, nor was level of caregiver depressive symptoms. Implications of these data for case management, the provision of in-home respite services, and future research are discussed. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Home Health Care Management & Practice AU - Mensie, Lauren C AU - Steffen, Ann M AD - St. Louis VA Medical Center, I Jefferson Barracks Drive (116B/JB), St Louis, Missouri, MO 63125 E-mail: Lauren.Mensie2@va.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 109 EP - 117 PB - Sage Publications, Thousand Oaks CA VL - 23 IS - 2 SN - 1084-8223, 1084-8223 KW - respite, service utilization, family caregivers KW - Case management KW - Elderly people KW - Functional impairment KW - Dysfunction KW - Helpseeking KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875713337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Home+Health+Care+Management+%26+Practice&rft.atitle=Predicting+In-Home+Respite+Utilization+by+Family+Caregivers+of+Older+Adults%3A+Results+of+a+Community+Study&rft.au=Mensie%2C+Lauren+C%3BSteffen%2C+Ann+M&rft.aulast=Mensie&rft.aufirst=Lauren&rft.date=2011-04-01&rft.volume=23&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Home+Health+Care+Management+%26+Practice&rft.issn=10848223&rft_id=info:doi/10.1177%2F1084822310384694 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-07-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Carers; Elderly people; Dysfunction; Helpseeking; Case management; Functional impairment DO - http://dx.doi.org/10.1177/1084822310384694 ER - TY - JOUR T1 - Combination of family history of suicidal behavior and childhood trauma may represent correlate of increased suicide risk AN - 875712312; 201113414 AB - There is a need to try to identify patients at highest risk for suicidal behavior. A family history of suicidal behavior (FHS) and childhood trauma are two important risk factors for suicidal behavior. It was therefore decided to combine them and examine if the combination would identify patients at even increased risk for suicidal behavior. Methods: Two hundred and eighty one substance dependent patients with a FHS completed the Childhood Trauma Questionnaire (CTQ) and were interviewed about their lifetime history of suicidal behavior. Patients with the combination of a FHS and CTQ score above the mean were examined and compared with FHS patients with a CTQ score below the mean. Results: One hundred and two of the 129 (79.1%) FHS patients with a CTQ score above the mean had attempted suicide. Thirty five of the 40 female (87.5%) FHS patients with a CTQ score above the mean had attempted suicide .Patients with a CTQ score above the mean were found significantly more among FHS patients who had attempted suicide than among FHS patients who had never attempted. FHS attempters with a CTQ score above the mean had a significantly earlier age of first attempting and had made more attempts than FHS attempters with a CTQ score below the mean. Limitations: Childhood trauma data derived from self-report questionnaire. No consistent collateral information about FHS. Conclusion: The combination of a FHS and childhood trauma may represent a correlate of increased risk of attempting suicide, attempting earlier, and making more attempts. [Copyright Elsevier B.V.] JF - Journal of Affective Disorders AU - Roy, Alec AD - Psychiatry Service 116A, Department of Veterans Affairs, New Jersey Healthcare System, 385 Tremont Avenue, East Orange, NJ, 070818, USA Alec.Roy@va.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 205 EP - 208 PB - Elsevier Ltd, The Netherlands VL - 130 IS - 1-2 SN - 0165-0327, 0165-0327 KW - Family History Suicide Childhood Trauma Attempted suicide KW - Suicidal behaviour KW - Childhood abuse KW - Parasuicide KW - Family histories KW - Suicide KW - Selfreport KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875712312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Affective+Disorders&rft.atitle=Combination+of+family+history+of+suicidal+behavior+and+childhood+trauma+may+represent+correlate+of+increased+suicide+risk&rft.au=Roy%2C+Alec&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2011-04-01&rft.volume=130&rft.issue=1-2&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Journal+of+Affective+Disorders&rft.issn=01650327&rft_id=info:doi/10.1016%2Fj.jad.2010.09.022 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-07-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Suicidal behaviour; Childhood abuse; Parasuicide; Family histories; Suicide; Selfreport DO - http://dx.doi.org/10.1016/j.jad.2010.09.022 ER - TY - JOUR T1 - Factors associated with suicidal ideation in OEF/OIF veterans AN - 875712155; 201113193 AB - The purpose of this project was to examine factors associated with suicidal ideation in returning Iraq and Afghanistan war veterans. Methods: A cross-sectional review of 1740 veterans' initial mental health screening evaluations. One-hundred and thirteen (6.5%) OEF/OIF veterans reported active suicidal ideation at the time of the interview. Results: Prior exposures of physical or sexual abuse and having a history of a prior suicide attempt(s) were associated with the presence of current suicidal ideation, as were having a diagnosis of a psychotic disorder, a depressive disorder, or posttraumatic stress disorder (PTSD). Deployment concerns related to training (protective), the deployment environment, family concerns, deployment concerns, post-deployment support (protective), and post-deployment stressors were also associated with current suicidal ideation. Logistic regression analysis revealed the major risk factors were having a prior suicide attempt, female gender, and a depressive disorder diagnosis; while more perceived current social support was a protective factor. Logistic regression analysis also revealed having comorbid PTSD and depression carried a higher odds ratio for risk than did having either PTSD or depression alone; and that the PTSD avoidance symptom-cluster was associated with more risk than either the re-experiencing or hyper-arousal symptom clusters for current suicidal ideation. Limitations: As a cross-sectional retrospective medical chart review, limitations include limited generalizability and causal relationships cannot be evaluated. Conclusions: Further investigation of these risk factors is warranted to aid in suicide risk assessment and in the development of targeted interventions to mitigate the identified risk factors and bolster the identified protective factor. [Copyright Elsevier B.V.] JF - Journal of Affective Disorders AU - Lemaire, Chad M AU - Graham, David P AD - The Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 231 EP - 238 PB - Elsevier Ltd, The Netherlands VL - 130 IS - 1-2 SN - 0165-0327, 0165-0327 KW - Veterans Suicide Posttraumatic Stress Disorder Depression KW - Veterans KW - Protective factors KW - Posttraumatic stress disorder KW - Risk factors KW - Suicidal ideation KW - Deployment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875712155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Affective+Disorders&rft.atitle=Factors+associated+with+suicidal+ideation+in+OEF%2FOIF+veterans&rft.au=Lemaire%2C+Chad+M%3BGraham%2C+David+P&rft.aulast=Lemaire&rft.aufirst=Chad&rft.date=2011-04-01&rft.volume=130&rft.issue=1-2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Journal+of+Affective+Disorders&rft.issn=01650327&rft_id=info:doi/10.1016%2Fj.jad.2010.10.021 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-07-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Suicidal ideation; Posttraumatic stress disorder; Veterans; Deployment; Risk factors; Protective factors DO - http://dx.doi.org/10.1016/j.jad.2010.10.021 ER - TY - JOUR T1 - A test of written emotional disclosure as an intervention for posttraumatic stress disorder AN - 870995814; 201112603 AB - This study examined the efficacy of the written emotional disclosure (WED) procedure with a sample of young adults who met diagnostic criteria for posttraumatic stress disorder (PTSD). Participants were randomly assigned to either WED or a control writing condition and were assessed at baseline and one month following the writing sessions. During each writing session, participants' heart rate was recorded; participants also provided self-report ratings of emotional responding. Findings indicated no significant group differences for PTSD and depression symptom severity at follow-up assessment. Relative to control participants, WED participants displayed significantly greater heart rate activity and reported greater emotional responding during the first writing session; however, no reduction in emotional responding occurred for either condition from the first to the last writing session. Taken together, these findings indicate that WED may not be an efficacious intervention for PTSD. Suggestions are made for future work in this area. [Copyright Elsevier Ltd.] JF - Behaviour Research and Therapy AU - Sloan, Denise M AU - Marx, Brian P AU - Greenberg, Eva M AD - National Center for PTSD (116B-2), VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA 02130, USA denise.sloan@va.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 299 EP - 304 PB - Elsevier, Amsterdam The Netherlands VL - 49 IS - 4 SN - 0005-7967, 0005-7967 KW - PTSD Trauma Depression Written disclosure Exposure therapy KW - Symptoms KW - Posttraumatic stress disorder KW - Efficacy KW - Heart rate KW - Selfreport KW - Disclosure KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870995814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behaviour+Research+and+Therapy&rft.atitle=A+test+of+written+emotional+disclosure+as+an+intervention+for+posttraumatic+stress+disorder&rft.au=Sloan%2C+Denise+M%3BMarx%2C+Brian+P%3BGreenberg%2C+Eva+M&rft.aulast=Sloan&rft.aufirst=Denise&rft.date=2011-04-01&rft.volume=49&rft.issue=4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Behaviour+Research+and+Therapy&rft.issn=00057967&rft_id=info:doi/10.1016%2Fj.brat.2011.02.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-06-07 N1 - Last updated - 2016-09-27 N1 - CODEN - BRTHAA N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Heart rate; Disclosure; Selfreport; Symptoms; Efficacy DO - http://dx.doi.org/10.1016/j.brat.2011.02.001 ER - TY - JOUR T1 - Prospective risk factors for new-onset post-traumatic stress disorder in National Guard soldiers deployed to Iraq AN - 868221269; 201111941 AB - Background. National Guard troops are at increased risk for post-traumatic stress disorder (PTSD); however, little is known about risk and resilience in this population. Method. The Readiness and Resilience in National Guard Soldiers Study is a prospective, longitudinal investigation of 522 Army National Guard troops deployed to Iraq from March 2006 to July 2007. Participants completed measures of PTSD symptoms and potential risk/protective factors 1 month before deployment. Of these, 81% (n=424) completed measures of PTSD, deployment stressor exposure and post-deployment outcomes 2-3 months after returning from Iraq. New onset of probable PTSD 'diagnosis' was measured by the PTSD Checklist -- Military (PCL-M). Independent predictors of new-onset probable PTSD were identified using hierarchical logistic regression analyses. Results. At baseline prior to deployment, 3.7% had probable PTSD. Among soldiers without PTSD symptoms at baseline, 13.8% reported post-deployment new-onset probable PTSD. Hierarchical logistic regression adjusted for gender, age, race/ethnicity and military rank showed that reporting more stressors prior to deployment predicted new-onset probable PTSD [odds ratio (OR) 2.20] as did feeling less prepared for deployment (OR 0.58). After accounting for pre-deployment factors, new-onset probable PTSD was predicted by exposure to combat (OR 2.19) and to combat's aftermath (OR 1.62). Reporting more stressful life events after deployment (OR 1.96) was associated with increased odds of new-onset probable PTSD, while post-deployment social support (OR 0.31) was a significant protective factor in the etiology of PTSD. Conclusions. Combat exposure may be unavoidable in military service members, but other vulnerability and protective factors also predict PTSD and could be targets for prevention strategies. Adapted from the source document. JF - Psychological Medicine AU - Polusny, M A AU - Erbes, C R AU - Murdoch, M AU - Arbisi, P A AU - Thuras, P AU - Rath, M B AD - Minneapolis VA Health Care System (116A9), One Veterans Drive, Minneapolis, MN 55417, USA E-mail: melissa.polusny@va.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 687 EP - 698 PB - Cambridge University Press, UK VL - 41 IS - 4 SN - 0033-2917, 0033-2917 KW - Combat, military personnel, prospective studies, PTSD, risk factors KW - Resilience KW - Protective factors KW - Posttraumatic stress disorder KW - Soldiers KW - Iraq KW - Deployment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868221269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Prospective+risk+factors+for+new-onset+post-traumatic+stress+disorder+in+National+Guard+soldiers+deployed+to+Iraq&rft.au=Polusny%2C+M+A%3BErbes%2C+C+R%3BMurdoch%2C+M%3BArbisi%2C+P+A%3BThuras%2C+P%3BRath%2C+M+B&rft.aulast=Polusny&rft.aufirst=M&rft.date=2011-04-01&rft.volume=41&rft.issue=4&rft.spage=687&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291710002047 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-05-18 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Deployment; Soldiers; Protective factors; Iraq; Resilience DO - http://dx.doi.org/10.1017/S0033291710002047 ER - TY - JOUR T1 - Treatment of Community-Acquired Pneumonia in an Ambulatory Setting AN - 862784567; 14618901 AB - Community-acquired pneumonia continues to be a significant cause of morbidity and mortality despite broad-spectrum antibiotics and advances in critical care. Frequently, the diagnosis is confounded by coexisting cardiac or pulmonary conditions. Recognition of patients at risk for complications from pneumonia is critical when making the decision of how and where to treat. This review summarizes the diagnosis and treatment of community-acquired pneumonia with oral antibiotics in an outpatient setting. Specific pathogens and clinical presentations in certain at-risk populations are highlighted. Also presented are validated algorithms for evaluating and identifying patients who may be at risk for serious complications of pneumonia and require treatment in an inpatient setting. JF - American Journal of Medicine AU - Butt, Saira AU - Swiatlo, Edwin AD - Department of Medicine, Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, Miss, Edwin.swiatlo@va.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 297 EP - 300 PB - Elsevier BV, PO Box 10670 Riverton, NJ 08076 USA VL - 124 IS - 4 SN - 0002-9343, 0002-9343 KW - Risk Abstracts KW - Mortality KW - Antibiotics KW - Pathogens KW - Morbidity KW - complications KW - Reviews KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862784567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Medicine&rft.atitle=Treatment+of+Community-Acquired+Pneumonia+in+an+Ambulatory+Setting&rft.au=Butt%2C+Saira%3BSwiatlo%2C+Edwin&rft.aulast=Butt&rft.aufirst=Saira&rft.date=2011-04-01&rft.volume=124&rft.issue=4&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Medicine&rft.issn=00029343&rft_id=info:doi/10.1016%2Fj.amjmed.2010.06.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; complications; Reviews; Antibiotics; Pathogens; Morbidity DO - http://dx.doi.org/10.1016/j.amjmed.2010.06.027 ER - TY - JOUR T1 - Changing paradigms in the treatment of malignant pheochromocytoma. AN - 859742583; 21451453 AB - Pheochromocytomas and paragangliomas are intra- and extra-adrenal neoplasms that are rarely malignant. The treatment of those that are malignant has remained a challenge because little was known about the molecular pathways involved in its malignant transformation. Recently, however, the genetic and molecular changes involved in malignant pheochromocytoma have come to be understood. The authors review the recent literature about the changing treatment options for malignant pheochromocytomas and paragangliomas. Traditional treatments for malignant pheochromocytoma remain unsuccessful. With the advances made in genomics and proteomics, novel pathways in pheochromocytoma carcinogenesis are becoming the targets of new treatment strategies and show promising results. Although several studies and clinical trials show great promise for improving the treatment of pheochromocytomas and paragangliomas, the hope is that future collaborative efforts will allow for prospective clinical trials using an evidenced-based approach. JF - Cancer control : journal of the Moffitt Cancer Center AU - Grogan, Raymon H AU - Mitmaker, Elliot J AU - Duh, Quan-Yang AD - Department of Endocrine Surgery, University of California, San Francisco, CA 94143, USA. quan-yang.duh@med.va.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 104 EP - 112 VL - 18 IS - 2 KW - 3-Iodobenzylguanidine KW - 35MRW7B4AD KW - Index Medicus KW - Humans KW - Molecular Targeted Therapy KW - 3-Iodobenzylguanidine -- therapeutic use KW - Catheter Ablation KW - Adrenal Gland Neoplasms -- genetics KW - Pheochromocytoma -- genetics KW - Pheochromocytoma -- therapy KW - Adrenal Gland Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/859742583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+control+%3A+journal+of+the+Moffitt+Cancer+Center&rft.atitle=Changing+paradigms+in+the+treatment+of+malignant+pheochromocytoma.&rft.au=Grogan%2C+Raymon+H%3BMitmaker%2C+Elliot+J%3BDuh%2C+Quan-Yang&rft.aulast=Grogan&rft.aufirst=Raymon&rft.date=2011-04-01&rft.volume=18&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Cancer+control+%3A+journal+of+the+Moffitt+Cancer+Center&rft.issn=1526-2359&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-13 N1 - Date created - 2011-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland. AN - 858778508; 21435446 AB - Calcineurin is an important signal transduction mediator in T cells, neurons, the heart, and kidneys. Recent evidence points to unique actions of the two main isoforms of the catalytic subunit. Although the β isoform is required for T-cell development, α is important in the brain and kidney. In addition, mice lacking α but not β suffer from failure to thrive and early mortality. The purpose of this study was to identify the cause of postnatal death of calcineurin α null (CnAα(-/-)) mice and to determine the mechanism of α activity that contributes to the phenotype. CnAα(-/-) mice and wild-type littermate controls were fed a modified diet and then salivary gland function and histology were examined. In vitro studies were performed to identify the mechanism of α action. Data show that calcineurin is required for normal submandibular gland function and secretion of digestive enzymes. Loss of α does not impair nuclear factor of activated T-cell activity or expression but results in impaired protein trafficking downstream of the inositol trisphosphate receptor. These findings show a novel function of calcineurin in digestion and protein trafficking. Significantly, these data also provide a mechanism to rescue to adulthood a valuable animal model of calcineurin inhibitor-mediated neuronal and renal toxicities. Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved. JF - The American journal of pathology AU - Reddy, Ramesh N AU - Pena, Juan A AU - Roberts, Brian R AU - Williams, Stephen R AU - Price, S Russ AU - Gooch, Jennifer L AD - Atlanta Veterans Administration Medical Center, Decatur, GA 30322-0001, USA. Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 1605 EP - 1613 VL - 178 IS - 4 KW - Protein Isoforms KW - 0 KW - Luciferases KW - EC 1.13.12.- KW - Calcineurin KW - EC 3.1.3.16 KW - PPP3CA protein, human KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Kidney -- metabolism KW - Neurons -- metabolism KW - Luciferases -- metabolism KW - Brain -- metabolism KW - Immunohistochemistry -- methods KW - Mice KW - Mice, Transgenic KW - Subcellular Fractions -- metabolism KW - Signal Transduction KW - Female KW - Male KW - Protein Transport KW - Calcineurin -- physiology KW - Calcineurin -- metabolism KW - Calcineurin -- genetics KW - Salivary Glands -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/858778508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=Rescue+of+calcineurin+A%CE%B1%28-%2F-%29+mice+reveals+a+novel+role+for+the+%CE%B1+isoform+in+the+salivary+gland.&rft.au=Reddy%2C+Ramesh+N%3BPena%2C+Juan+A%3BRoberts%2C+Brian+R%3BWilliams%2C+Stephen+R%3BPrice%2C+S+Russ%3BGooch%2C+Jennifer+L&rft.aulast=Reddy&rft.aufirst=Ramesh&rft.date=2011-04-01&rft.volume=178&rft.issue=4&rft.spage=1605&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=1525-2191&rft_id=info:doi/10.1016%2Fj.ajpath.2010.12.054 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-15 N1 - Date created - 2011-03-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2001 Oct 19;276(42):38787-94 [11483593] Annu Rev Immunol. 1997;15:707-47 [9143705] In Vitro Cell Dev Biol Anim. 1998 Jan;34(1):58-67 [9542637] Cell Signal. 1998 Oct;10(9):599-611 [9794241] Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4650-5 [10200317] Science. 2005 Sep 30;309(5744):2232-4 [16195467] Int J Paediatr Dent. 2005 Nov;15(6):403-11 [16238650] Cell Mol Life Sci. 2005 Nov;62(21):2477-86 [16231093] J Cell Sci. 2006 Jun 15;119(Pt 12):2468-76 [16735444] Transplantation. 2007 Feb 27;83(4):439-47 [17318077] Biochem Biophys Res Commun. 2007 Oct 19;362(2):288-94 [17719012] Cell Calcium. 2008 May;43(5):515-9 [17904633] Biochemistry. 2009 Mar 10;48(9):1900-10 [19154138] J Cell Mol Med. 2011 Feb;15(2):414-22 [19778355] Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4586-91 [11904392] Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9398-403 [12091710] J Biol Chem. 2002 Dec 27;277(52):50776-9 [12377773] Mol Cell Biol. 2003 Jun;23(12):4331-43 [12773574] Circ Res. 2004 Jan 9;94(1):110-8 [14656927] J Biol Chem. 2004 Jun 18;279(25):26192-200 [15082723] Am J Pathol. 2004 Nov;165(5):1755-65 [15509543] Drugs. 1993 Jun;45(6):953-1040 [7691501] Cell. 1995 Nov 3;83(3):463-72 [8521476] J Exp Med. 1996 Feb 1;183(2):413-20 [8627154] J Neuropathol Exp Neurol. 1996 Aug;55(8):924-31 [8759782] J Neurochem. 1997 Apr;68(4):1668-78 [9084440] Prog Transplant. 2001 Dec;11(4):271-82; quiz 283-4 [11871276] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ajpath.2010.12.054 ER - TY - JOUR T1 - Calcium oxalate monohydrate crystals: a clue to ethylene glycol poisoning. AN - 858776270; 20571351 JF - The American journal of the medical sciences AU - Luqman, Ashar AU - Stanifer, John AU - Asif Siddiqui, Omer M AU - Naseer, Adnan AU - Wall, Barry M AD - Nephrology Section, VA Medical Center, Memphis, Tennessee, USA. Barry.Wall@va.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 338 VL - 341 IS - 4 KW - Antidotes KW - 0 KW - Pyrazoles KW - Calcium Oxalate KW - 2612HC57YE KW - fomepizole KW - 83LCM6L2BY KW - Ethylene Glycol KW - FC72KVT52F KW - Abridged Index Medicus KW - Index Medicus KW - Crystallization KW - Humans KW - Treatment Outcome KW - Antidotes -- therapeutic use KW - Pyrazoles -- therapeutic use KW - Middle Aged KW - Renal Dialysis KW - Male KW - Poisoning -- urine KW - Calcium Oxalate -- urine KW - Poisoning -- therapy KW - Poisoning -- diagnosis KW - Ethylene Glycol -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/858776270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Calcium+oxalate+monohydrate+crystals%3A+a+clue+to+ethylene+glycol+poisoning.&rft.au=Luqman%2C+Ashar%3BStanifer%2C+John%3BAsif+Siddiqui%2C+Omer+M%3BNaseer%2C+Adnan%3BWall%2C+Barry+M&rft.aulast=Luqman&rft.aufirst=Ashar&rft.date=2011-04-01&rft.volume=341&rft.issue=4&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=1538-2990&rft_id=info:doi/10.1097%2FMAJ.0b013e3181e15dbd LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-19 N1 - Date created - 2011-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MAJ.0b013e3181e15dbd ER - TY - JOUR T1 - Variations In Efficiency And The Relationship To Quality Of Care In The Veterans Health System AN - 1030867280; 201205321 AB - There is widespread belief that the US health care system could realize significant improvements in efficiency, savings, and patient outcomes if care were provided in a more integrated and accountable way. We examined efficiency and its relationship to quality of care for medical centers run by the Veterans Health Administration of the Department of Veterans Affairs (VA), a national, vertically integrated health care system that is accountable for a large patient population. After devising a statistical model to indicate efficiency we found that VA medical centers were highly efficient. We also found only modest variation in the level of efficiency and cost across VA medical centers, and a positive correlation overall between greater efficiency and higher inpatient quality These findings for VA medical centers suggest that efforts to drive integration and accountability in other parts of the US health care system might have important payoffs in reducing variations in cost without sacrificing quality Policy makers should focus on what aspects of certain VA medical centers allow them to provide better care at lower costs and consider policies that incentivize other providers, both within and outside the VA, to adopt these practices. Adapted from the source document. JF - Health Affairs AU - Gao, Jian AU - Moran, Eileen AU - Almenoff, Peter L AU - Render, Marta L AU - Campbell, James AU - Jha, Ashish K AD - Productivity, Efficiency, and Staffing Department of Veterans Affairs, in Albany, New York jian.gao@va.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 655 EP - 663 PB - Project HOPE, Bethesda MD VL - 30 IS - 4 SN - 0278-2715, 0278-2715 KW - Veterans KW - Policy Making KW - Quality of Health Care KW - United States of America KW - Patients KW - Medicine KW - Social Integration KW - Health Care Costs KW - Health Care Services KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030867280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Variations+In+Efficiency+And+The+Relationship+To+Quality+Of+Care+In+The+Veterans+Health+System&rft.au=Gao%2C+Jian%3BMoran%2C+Eileen%3BAlmenoff%2C+Peter+L%3BRender%2C+Marta+L%3BCampbell%2C+James%3BJha%2C+Ashish+K&rft.aulast=Gao&rft.aufirst=Jian&rft.date=2011-04-01&rft.volume=30&rft.issue=4&rft.spage=655&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2010.0435 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Quality of Health Care; Health Care Services; Medicine; Veterans; Health Care Costs; United States of America; Patients; Policy Making; Social Integration DO - http://dx.doi.org/10.1377/hlthaff.2010.0435 ER - TY - JOUR T1 - Effects of parents' experiential avoidance and PTSD on adolescent disaster-related posttraumatic stress symptomatology. AN - 1023096189; 201217499 AB - Despite the importance of family context to adolescents' reactions following disaster, little research has examined the role of parents' functioning on adolescents' disaster-related posttraumatic stress disorder (PTSD) symptoms. Using data from 288 adolescents (ages 12 to 19 years) and 288 parents exposed to a series of severe tornadoes in a rural Midwestern community, this study tested a conceptual model of the interrelationships between individual and parental risk factors on adolescents' disaster-related PTSD symptoms using structural equation modeling. Results showed that the psychological process of experiential avoidance mediated the relationship between family disaster exposure and PTSD for both adolescents and their parents. Parents' PTSD symptoms independently predicted adolescents' PTSD symptoms. Further, parents' postdisaster functioning amplified the effects of adolescent experiential avoidance on adolescents' disaster-related PTSD symptoms. Findings highlight the importance of family context in understanding adolescents' postdisaster reactions. Clinical implications are discussed. [Copyright The American Psychological Association.] JF - Journal of Family Psychology AU - Polusny, Melissa A AU - Ries, Barry J AU - Meis, Laura A AU - DeGarmo, David AU - McCormick-Deaton, Catherine M AU - Thuras, Paul AU - Erbes, Christopher R AD - Minneapolis VA Medical Center melissa.polusny@va.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 220 EP - 229 PB - American Psychological Association, Washington DC VL - 25 IS - 2 SN - 0893-3200, 0893-3200 KW - Symptoms KW - Posttraumatic stress disorder KW - Avoidance KW - Disasters KW - Parents KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023096189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Psychology&rft.atitle=Effects+of+parents%27+experiential+avoidance+and+PTSD+on+adolescent+disaster-related+posttraumatic+stress+symptomatology.&rft.au=Polusny%2C+Melissa+A%3BRies%2C+Barry+J%3BMeis%2C+Laura+A%3BDeGarmo%2C+David%3BMcCormick-Deaton%2C+Catherine+M%3BThuras%2C+Paul%3BErbes%2C+Christopher+R&rft.aulast=Polusny&rft.aufirst=Melissa&rft.date=2011-04-01&rft.volume=25&rft.issue=2&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Psychology&rft.issn=08933200&rft_id=info:doi/10.1037%2Fa0022945 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JFPSEV N1 - SubjectsTermNotLitGenreText - Adolescents; Posttraumatic stress disorder; Parents; Symptoms; Avoidance; Disasters DO - http://dx.doi.org/10.1037/a0022945 ER - TY - JOUR T1 - Developing Frontline Staff in Performance Improvement: Part 1: Tools for Success AN - 1023095373; 201216724 AB - At the urging of consumers and third party payers, many organizational report cards are now available at the click of a button. These reports can aid consumers in deciding where to receive healthcare services. Third party payers also use patient outcome data when determining which facilities to include in their networks. These reports are by no means completely reliable, but measures have been taken to ensure risk-adjusted data are provided. [1], [2] and [3]. [Copyright Elsevier B.V.] JF - Nurse Leader AU - Meredith, Erin K Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 50 EP - 53 PB - Elsevier Ltd, The Netherlands VL - 9 IS - 2 SN - 1541-4612, 1541-4612 KW - Clinical outcomes KW - Third parties KW - Health care KW - Risk adjustment KW - Consumers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023095373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nurse+Leader&rft.atitle=Developing+Frontline+Staff+in+Performance+Improvement%3A+Part+1%3A+Tools+for+Success&rft.au=Meredith%2C+Erin+K&rft.aulast=Meredith&rft.aufirst=Erin&rft.date=2011-04-01&rft.volume=9&rft.issue=2&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Nurse+Leader&rft.issn=15414612&rft_id=info:doi/10.1016%2Fj.mnl.2011.01.015 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Third parties; Consumers; Risk adjustment; Clinical outcomes; Health care DO - http://dx.doi.org/10.1016/j.mnl.2011.01.015 ER - TY - JOUR T1 - Posttraumatic stress and marijuana use coping motives: The mediating role of distress tolerance AN - 1023093264; 201217522 AB - The present investigation examined the explanatory (i.e,. mediating) role of distress tolerance (DT) in the relation between posttraumatic stress (PTS) symptom severity and marijuana use coping motives. The sample consisted of 142 adults (46.5% women; Mage = 22.18, SD = 7.22, range = 18-55), who endorsed exposure to at least one Criterion A traumatic life event (DSM-IV-TR, 2000) and reported marijuana use within the past 30 days. As predicted, results demonstrated that DT partially mediated the relation between PTS symptom severity and coping-oriented marijuana use. These preliminary results suggest that DT may be an important cognitive-affective mechanism underlying the PTS-marijuana use coping motives association. Theoretically, trauma-exposed marijuana users with greater PTS symptom severity may use marijuana to cope with negative mood states, at least partially because of a lower perceived capacity to withstand emotional distress. [Copyright Elsevier B.V.] JF - Journal of Anxiety Disorders AU - Potter, Carrie M AU - Vujanovic, Anka A AU - Marshall-Berenz, Erin C AU - Bernstein, Amit AU - Bonn-Miller, Marcel O Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 437 EP - 443 PB - Elsevier Ltd, The Netherlands VL - 25 IS - 3 SN - 0887-6185, 0887-6185 KW - Trauma KW - Posttraumatic stress KW - Distress tolerance KW - Marijuana KW - Coping KW - Symptoms KW - Traumatic life events KW - Posttraumatic stress disorder KW - Severity KW - Cannabis KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023093264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Anxiety+Disorders&rft.atitle=Posttraumatic+stress+and+marijuana+use+coping+motives%3A+The+mediating+role+of+distress+tolerance&rft.au=Potter%2C+Carrie+M%3BVujanovic%2C+Anka+A%3BMarshall-Berenz%2C+Erin+C%3BBernstein%2C+Amit%3BBonn-Miller%2C+Marcel+O&rft.aulast=Potter&rft.aufirst=Carrie&rft.date=2011-04-01&rft.volume=25&rft.issue=3&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Journal+of+Anxiety+Disorders&rft.issn=08876185&rft_id=info:doi/10.1016%2Fj.janxdis.2010.11.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cannabis; Symptoms; Coping; Severity; Posttraumatic stress disorder; Traumatic life events DO - http://dx.doi.org/10.1016/j.janxdis.2010.11.007 ER - TY - JOUR T1 - Acceptability of dementia screening in primary care patients AN - 1017968991; 16699067 AB - Objectives To determine the acceptability of dementia screening in two populations of older adults in different primary care settings. Methods Cross-sectional study of consecutive patients presenting for primary care appointments in the Duke University Health System (n=152) or Durham VA Medical Center (n=193) were evaluated face to face using the Dementia Screening and Perceived Harms (SAPH) questionnaire. Results Overall, 81% of primary care patients indicated that they would want to be screened to determine if they are developing dementia. After exposure to possible risks and benefits of screening, 86% of patients indicated they would like to be screened. The SAPH was easy to use and contained five relevant and cohesive domains. The items most associated with a desire for dementia screening were male gender, acceptance of other types of screening, and a belief that a treatment for dementia exists. Conclusions Primary care patients in two different health care systems indicated they would like to be screened for dementia. The SAPH was easy to use and contains cohesive domains. JF - International Journal of Geriatric Psychiatry AU - Holsinger, Tracey AU - Boustani, Malaz AU - Abbot, David AU - Williams, John W Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 373 EP - 379 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 26 IS - 4 SN - 1099-1166, 1099-1166 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Acceptability KW - Cost-benefit analysis KW - Dementia disorders KW - Gender KW - Geriatrics KW - Health care KW - Inventories KW - Perception KW - dementia disorders KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017968991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Geriatric+Psychiatry&rft.atitle=Acceptability+of+dementia+screening+in+primary+care+patients&rft.au=Holsinger%2C+Tracey%3BBoustani%2C+Malaz%3BAbbot%2C+David%3BWilliams%2C+John+W&rft.aulast=Holsinger&rft.aufirst=Tracey&rft.date=2011-04-01&rft.volume=26&rft.issue=4&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Geriatric+Psychiatry&rft.issn=10991166&rft_id=info:doi/10.1002%2Fgps.2536 L2 - http://onlinelibrary.wiley.com/doi/10.1002/gps.2536/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Cost-benefit analysis; Inventories; Dementia disorders; Geriatrics; Health care; Perception; Gender; Acceptability; dementia disorders DO - http://dx.doi.org/10.1002/gps.2536 ER - TY - JOUR T1 - Regression-Based Estimates of Observed Functional Status in Centenarians AN - 1010633568; 201202012 AB - Purpose of the Study: There is lack of consensus on the best method of functional assessment, and there is a paucity of studies on daily functioning in centenarians. We sought to compare associations between performance-based, self-report, and proxy report of functional status in centenarians. We expected the strongest relationships between proxy reports and observed performance of basic activities of daily living (BADLs) and instrumental activities of daily living (IADLs). We hypothesized that the discrepancy between self-report and observed daily functioning would be modified by cognitive status. We additionally sought to provide clinicians with estimates of centenarians' observed daily functioning based on their mental status in combination with subjective measures of activities of daily living (ADLs). Design and Methods: Two hundred and forty-four centenarians from the Georgia Centenarian Study were included in this cross-sectional population-based study. Measures included the Direct Assessment of Functional Status, self-report and proxy report of functional status, and the Mini-Mental State Examination (MMSE). Results: Associations between observed and proxy reports were stronger than between observed and self-report across BADL and IADL measures. A significant MMSE by type of report interaction was found, indicating that lower MMSE performance is associated with a greater discrepancy between subjective and objective ADL measures. Implications: Results demonstrate associations between 3 methods of assessing functional status and suggest proxy reports are generally more accurate than self-report measures. Cognitive status accounted for some of the discrepancy between observed and self-reports, and we provide clinicians with tables to estimate centenarians' performance on observed functional measures based on MMSE and subjective report of functional status. Adapted from the source document. JF - The Gerontologist AU - Mitchell, Meghan B AU - Miller, L Stephen AU - Woodard, John L AU - Davey, Adam AU - Martin, Peter AU - Burgess, Molly AU - Poon, Leonard W AD - Department of Psychology & Institute of Gerontology, University of Georgia, Athens meghan.mitchell2@va.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 179 EP - 189 PB - Gerontological Society of America, Washington DC VL - 51 IS - 2 SN - 0016-9013, 0016-9013 KW - Daily functioning, Direct Assessment of Functional Status, Self-report, Proxy-report, MMSE KW - Activities of Daily Living KW - Cognition KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010633568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=Regression-Based+Estimates+of+Observed+Functional+Status+in+Centenarians&rft.au=Mitchell%2C+Meghan+B%3BMiller%2C+L+Stephen%3BWoodard%2C+John+L%3BDavey%2C+Adam%3BMartin%2C+Peter%3BBurgess%2C+Molly%3BPoon%2C+Leonard+W&rft.aulast=Mitchell&rft.aufirst=Meghan&rft.date=2011-04-01&rft.volume=51&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/10.1093%2Fgeront%2Fgnq087 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Activities of Daily Living; Cognition DO - http://dx.doi.org/10.1093/geront/gnq087 ER - TY - CPAPER T1 - Polychlorinated Biphenyl 153 Worsens Dietinduced Obesity and Non-Alcoholic Fatty Liver Disease in C57/BL6 Mice T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313009938; 6047681 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Cave, M AU - McClain, C AU - Gregory, B AU - McCAllister, R AU - Falkner, K AU - Conklin, D AU - Young, D AU - Bhatnagar, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - obesity KW - Mice KW - PCB KW - Liver KW - Obesity KW - polychlorinated biphenyls KW - Fatty liver UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313009938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Polychlorinated+Biphenyl+153+Worsens+Dietinduced+Obesity+and+Non-Alcoholic+Fatty+Liver+Disease+in+C57%2FBL6+Mice&rft.au=Cave%2C+M%3BMcClain%2C+C%3BGregory%2C+B%3BMcCAllister%2C+R%3BFalkner%2C+K%3BConklin%2C+D%3BYoung%2C+D%3BBhatnagar%2C+A&rft.aulast=Cave&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Serum Cytokeratin 18 and Cytokine Elevations Suggest a High Prevelence of Occupational Liver Disease in Elastomer/Polymer Workers Highly-Exposed to Acrylonitrile, Butadiene, and Styrene T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312998452; 6046548 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Cave, M AU - Falkner, K AU - Costello, B AU - Gregory, B AU - Henry, L AU - McClain, C Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - acrylonitrile KW - Styrene KW - Liver diseases KW - Polymers KW - Acrylonitrile KW - Cytokines KW - Cytokeratin KW - Elastomers KW - Serum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312998452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Serum+Cytokeratin+18+and+Cytokine+Elevations+Suggest+a+High+Prevelence+of+Occupational+Liver+Disease+in+Elastomer%2FPolymer+Workers+Highly-Exposed+to+Acrylonitrile%2C+Butadiene%2C+and+Styrene&rft.au=Cave%2C+M%3BFalkner%2C+K%3BCostello%2C+B%3BGregory%2C+B%3BHenry%2C+L%3BMcClain%2C+C&rft.aulast=Cave&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Fear of Falling Among People Who Have Sustained a Stroke: A 6-Month Longitudinal Pilot Study AN - 925741955; 201205545 AB - OBJECTIVE. Fear of falling (FoF) after stroke is not well understood. We assessed change in FoF over the first 6 mo after a stroke and compared 6-mo anxiety, depression, balance, and quality of life (QoL) scores between people with and without baseline FoF (at the time of hospital discharge). METHOD. Data for this longitudinal study were collected at baseline and 6 mo. Of the 28 people included at baseline, 18 remained in the study 6 mo later. RESULTS. FoF significantly decreased over time (p = .015). Participants with baseline FoF had higher 6-mo anxiety and depression scores (s = .002 and .005, respectively) and lower QoL scores (p < .001) than did those without baseline FoF. CONCLUSION. The results are suggestive of the need for occupational therapists and their colleagues to consider anxiety and depression variables in managing the needs of poststroke participants experiencing FoF. Adapted from the source document. JF - The American Journal of Occupational Therapy AU - Schmid, Arlene A AU - Puymbroeck, Marieke Van AU - Knies, Kasie AU - Spangler-Morris, Carrie AU - Watts, Kathryn AU - Damush, Teresa AU - Williams, Linda S AD - Roudebush Veterans Affairs (VA) Medical Center, Health Services Research and Development (HSR&D) Center on Implementing Evidence-Based Practice, Indiana, USA arlene.schmid@va.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 125 EP - 132 PB - American Occupational Therapy Association, Bethesda MD VL - 65 IS - 2 SN - 0272-9490, 0272-9490 KW - accidental falls, anxiety, depression, fear, quality of life, stroke KW - Discharge KW - Falls KW - Strokes KW - Hospitals KW - Quality of life KW - Anxiety-Depression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925741955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Occupational+Therapy&rft.atitle=Fear+of+Falling+Among+People+Who+Have+Sustained+a+Stroke%3A+A+6-Month+Longitudinal+Pilot+Study&rft.au=Schmid%2C+Arlene+A%3BPuymbroeck%2C+Marieke+Van%3BKnies%2C+Kasie%3BSpangler-Morris%2C+Carrie%3BWatts%2C+Kathryn%3BDamush%2C+Teresa%3BWilliams%2C+Linda+S&rft.aulast=Schmid&rft.aufirst=Arlene&rft.date=2011-03-01&rft.volume=65&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Occupational+Therapy&rft.issn=02729490&rft_id=info:doi/10.5014%2Fajot.2011.000737 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Anxiety-Depression; Quality of life; Strokes; Falls; Hospitals; Discharge DO - http://dx.doi.org/10.5014/ajot.2011.000737 ER - TY - JOUR T1 - Demand Characteristics and Quality Improvement: Who is Fooling Whom AN - 896215852; 201117491 AB - Since some of the data used for quality assurance purposes (i.e. rating scales) requires the active participation of clinicians, administrators use various mandates or incentives to insure its collection. However, although improving clinician compliance these measures may bias clinician responses. It is suggested that the concept of 'demand characteristics' originally developed by Orne to describe how non-specific aspects of the experimental setting shape what the human subject does may be applicable. For example a measure that might increase clinician compliance with completing GAF ratings on an inpatient unit might also influence the scores to make them coincide with the expectation that all patients are very ill when admitted and improved when discharged. Why such a phenomenon would be difficult to detect and what it might say about the relationship between managers and those they manage is also explored. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - Luchins, Daniel J AD - Jesse Brown VAMC, 820 South Damen Ave. 116A, Chicago, IL, 60612, USA daniel.luchins@va.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 117 EP - 119 PB - Springer, Dordrecht The Netherlands VL - 38 IS - 2 SN - 0894-587X, 0894-587X KW - Inpatient treatment units KW - Quality assurance KW - Discharged KW - Compliance KW - Bias KW - Quality management KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896215852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Demand+Characteristics+and+Quality+Improvement%3A+Who+is+Fooling+Whom&rft.au=Luchins%2C+Daniel+J&rft.aulast=Luchins&rft.aufirst=Daniel&rft.date=2011-03-01&rft.volume=38&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-010-0301-4 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Compliance; Discharged; Quality assurance; Quality management; Inpatient treatment units; Bias DO - http://dx.doi.org/10.1007/s10488-010-0301-4 ER - TY - JOUR T1 - Training Experiences as Mediators of the Association Between Gender-Role Egalitarianism and Women's Adjustment to Marine Recruit Training AN - 896196851; 201121988 AB - Women may face particular challenges adjusting to the military environment, in part due to their numerical minority status in a traditionally male culture. In addition, women are more likely than men to experience the added stressor of sexual harassment. We examined several potential mediators of the relationship between gender-role egalitarianism and adjustment to boot camp training in a sample of 658 female U.S. Marine recruits. Results indicated that sexual harassment, performance stress, and unit cohesion mediated the relationship between egalitarianism and mental health symptomatology. These findings suggest that beliefs about gender roles are important to consider in efforts to improve women's adjustment in the military. Adapted from the source document. JF - Sex Roles: A Journal of Research AU - Weatherill, Robin P AU - Vogt, Dawne S AU - Taft, Casey T AU - King, Lynda A AU - King, Daniel W AU - Shipherd, Jillian C AD - National Center for PTSD, VA Boston Healthcare System, 150 South Huntington Avenue (116B-4), Boston, MA, 02130, USA robin.weatherill@va.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 348 EP - 359 PB - Springer Science+Business Media, Inc., New York NY VL - 64 IS - 5-6 SN - 0360-0025, 0360-0025 KW - Training KW - Males KW - Sexual Harassment KW - Stress KW - Females KW - Armed Forces KW - Egalitarianism KW - Adjustment KW - Sex Roles KW - article KW - 2983: feminist/gender studies; sociology of gender & gender relations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896196851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sex+Roles%3A+A+Journal+of+Research&rft.atitle=Training+Experiences+as+Mediators+of+the+Association+Between+Gender-Role+Egalitarianism+and+Women%27s+Adjustment+to+Marine+Recruit+Training&rft.au=Weatherill%2C+Robin+P%3BVogt%2C+Dawne+S%3BTaft%2C+Casey+T%3BKing%2C+Lynda+A%3BKing%2C+Daniel+W%3BShipherd%2C+Jillian+C&rft.aulast=Weatherill&rft.aufirst=Robin&rft.date=2011-03-01&rft.volume=64&rft.issue=5-6&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Sex+Roles%3A+A+Journal+of+Research&rft.issn=03600025&rft_id=info:doi/10.1007%2Fs11199-010-9921-0 LA - English DB - Sociological Abstracts N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-28 N1 - CODEN - SROLDH N1 - SubjectsTermNotLitGenreText - Females; Adjustment; Training; Egalitarianism; Sexual Harassment; Stress; Armed Forces; Males; Sex Roles DO - http://dx.doi.org/10.1007/s11199-010-9921-0 ER - TY - JOUR T1 - An Exploration of the Viability and Usefulness of the Construct of Moral Injury in War Veterans AN - 876246417; 14910519 AB - It is widely recognized that, along with physical and psychological injuries, war profoundly affects veterans spiritually and morally. However, research about the link between combat and changes in morality and spirituality is lacking. Moral injury is a construct that we have proposed to describe disruption in an individual's sense of personal morality and capacity to behave in a just manner. As a first step in construct validation, we asked a diverse group of health and religious professionals with many years of service to active duty warriors and veterans to provide commentary about moral injury. Respondents were given a semistructured interview and their responses were sorted. The transcripts were used to clarify the range of potentially and morally injurious experiences in war and the lasting sequelae of these experiences. There was strong support for the usefulness of the moral injury concept; however, respondents chiefly found our working definition to be inadequate. JF - Traumatology AU - Drescher, Kent D AU - Foy, David W AU - Kelly, Caroline AU - Leshner, Anna AU - Schutz, Kerrie AU - Litz, Brett AD - VA Palo Alto Health Care System, Menlo Park, CA, The Pathway Home: California Transition Center for Care of Combat Veterans, Yountville, CA, kent.drescher@va.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 8 EP - 13 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 17 IS - 1 SN - 1534-7656, 1534-7656 KW - Health & Safety Science Abstracts KW - Injuries KW - Psychology KW - war KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876246417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traumatology&rft.atitle=An+Exploration+of+the+Viability+and+Usefulness+of+the+Construct+of+Moral+Injury+in+War+Veterans&rft.au=Drescher%2C+Kent+D%3BFoy%2C+David+W%3BKelly%2C+Caroline%3BLeshner%2C+Anna%3BSchutz%2C+Kerrie%3BLitz%2C+Brett&rft.aulast=Drescher&rft.aufirst=Kent&rft.date=2011-03-01&rft.volume=17&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F1534765610395615 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Injuries; Psychology; war DO - http://dx.doi.org/10.1177/1534765610395615 ER - TY - JOUR T1 - Women Veterans' Reproductive Health Preferences and Experiences: A Focus Group Analysis AN - 875713175; 201113238 AB - Objective: Although women veterans are seeking care at the Veterans Administration (VA) in record numbers, there is little information regarding women veterans' experiences and preferences for reproductive health care services. We sought to characterize women veterans' experiences with, and preferences for, reproductive health services in the VA. Methods: We conducted five focus groups with a total of 25 participants using a semistructured interview guide to elicit women veterans' experiences and preferences with reproductive health care. Women veterans' utilizing VA health care at two VA facilities who responded to advertisements were selected on a first-come basis to participate in the study. We analyzed transcripts of these audiorecorded sessions using the constant comparative method of grounded theory. Results: Five main themes emerged from the focus group discussions: 1) Women veterans prefer VA women's clinics for comprehensive medical care; 2) Women veterans have had both positive and negative reproductive health experiences in the VA; 3) Women veterans experience knowledge gaps regarding VA coverage for reproductive health services; 4) Women veterans believe the VA should provide additional coverage for advanced infertility care and for newborns; and 5) Perceived gender discrimination shapes how women veterans view the VA. Conclusion: As the VA continues to tailor its services to women veterans, attention should be given to women's reproductive health care needs. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Mattocks, Kristin M AU - Nikolajski, Cara AU - Haskell, Sally AU - Brandt, Cynthia AU - McCall-Hosenfeld, Jennifer AU - Yano, Elizabeth AU - Pham, Tan AU - Borrero, Sonya AD - Yale University School of Medicine, Department of Internal Medicine, New Haven, VA Connecticut Healthcare System, 950 Campbell Avenue, 11-ACSLG. West Haven. cr 06516. Connecticut Tel: 413-548-6777, Fax: 203-937-4926 E-mail: Kristin.mattocks@va.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 124 EP - 129 PB - Elsevier Science, New York NY VL - 21 IS - 2 SN - 1049-3867, 1049-3867 KW - Veterans KW - Health care KW - Preferences KW - Women KW - Women's issues KW - Reproductive health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875713175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Women+Veterans%27+Reproductive+Health+Preferences+and+Experiences%3A+A+Focus+Group+Analysis&rft.au=Mattocks%2C+Kristin+M%3BNikolajski%2C+Cara%3BHaskell%2C+Sally%3BBrandt%2C+Cynthia%3BMcCall-Hosenfeld%2C+Jennifer%3BYano%2C+Elizabeth%3BPham%2C+Tan%3BBorrero%2C+Sonya&rft.aulast=Mattocks&rft.aufirst=Kristin&rft.date=2011-03-01&rft.volume=21&rft.issue=2&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2010.11.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-07-07 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Women; Veterans; Reproductive health; Health care; Preferences; Women's issues DO - http://dx.doi.org/10.1016/j.whi.2010.11.002 ER - TY - JOUR T1 - Twenty-Year Alcohol-Consumption and Drinking-Problem Trajectories of Older Men and Women AN - 875712086; 201112830 AB - Objective: The aim of this study was to describe older adults' 20-year alcohol-consumption and drinking-problem trajectories, identify baseline predictors of them, and determine whether older men and women differ on late-life drinking trajectory characteristics and predictors. Method: Two-group simultaneous latent growth modeling was used to describe the characteristics and baseline predictors of older community-residing men's (n =399) and women's (n = 320) 20-year drinking trajectories. Chi-square difference tests of increment in fit of latent growth models with and without gender invariance constraints were used to determine gender differences in drinking trajectory characteristics and predictors. Results: Unconditional quadratic growth models best described older individuals' within-individual, 20-year drinking trajectories, with alcohol consumption following an average pattern of delayed decline, and drinking problems an average pattern of decline followed by leveling off. On average, older men declined in alcohol consumption somewhat later than did older women. The best baseline predictors of more rapid decline in alcohol consumption and drinking problems were drinking variables indicative of heavier, more problematic alcohol use at late middle age. Conclusions: The course of alcohol consumption and drinking problems from late middle age onward is one of net decline, but this decline is neither swift nor invariable. Gender differences in the timing of decline in drinking suggest that ongoing monitoring of alcohol consumption may be especially important for older men. Further research is needed to identify factors known at late middle age that prospectively explain long-term change in late-life use of alcohol. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Brennan, Penny L AU - Schutte, Kathleen K AU - Moos, Bernice S AU - Moos, Rudolf H AD - Center for Health Care Evaluation (152-MPD), VA Palo Alto Health Care System, Menlo Park Division, 795 Willow Road, Menlo Park, CA 94025 E-mail: penny.brennan@va.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 308 EP - 321 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 72 IS - 2 SN - 1937-1888, 1937-1888 KW - Older men KW - Alcohol consumption KW - Alcohol related problems KW - Older women KW - Gender differences KW - Middle aged people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875712086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Twenty-Year+Alcohol-Consumption+and+Drinking-Problem+Trajectories+of+Older+Men+and+Women&rft.au=Brennan%2C+Penny+L%3BSchutte%2C+Kathleen+K%3BMoos%2C+Bernice+S%3BMoos%2C+Rudolf+H&rft.aulast=Brennan&rft.aufirst=Penny&rft.date=2011-03-01&rft.volume=72&rft.issue=2&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-07-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alcohol consumption; Older men; Middle aged people; Gender differences; Alcohol related problems; Older women ER - TY - JOUR T1 - VH3 Antibody Response to Immunization with Pneumococcal Polysaccharide Vaccine in Middle-Aged and Elderly Persons AN - 869573270; 14517948 AB - Pneumococcal disease continues to cause substantial morbidity and mortality among the elderly. Older adults may have high levels of anticapsular antibody after vaccination, but their antibodies show decreased functional activity. In addition, the protective effect of the pneumococcal polysaccharide vaccine (PPV) seems to cease as early as 3 to 5 years postvaccination. Recently, it was suggested that PPV elicits human antibodies that use predominantly VH3 gene segments and induce a repertoire shift with increased VH3 expression in peripheral B cells. Here we compared VH3-idiotypic antibody responses in middle-aged and elderly subjects receiving PPV as initial immunization or revaccination. We studied pre- and postvaccination sera from 36 (18 vaccine-naieve and 18 previously immunized subjects) middle-aged and 40 (22 vaccine-naieve and 18 previously immunized subjects) elderly adults who received 23-valent PPV. Concentrations of IgGs to four individual serotypes (6B, 14, 19F, and 23F) and of VH3-idiotypic antibodies (detected by the monoclonal antibody D12) to the whole pneumococcal vaccine were determined by enzyme-linked immunosorbent assay (ELISA). PPV elicited significant IgG and VH3-idiotypic antibody responses in middle-aged and elderly subjects, regardless of whether they were vaccine naieve or undergoing revaccination. Age did not influence the magnitude of the antibody responses, as evidenced by similar postvaccination IgG and VH3 antibody levels in both groups, even after stratifying by prior vaccine status. Furthermore, we found similar proportions (around 50%) of elderly and middle-aged subjects experiencing 2-fold increases in VH3 antibody titers after vaccination. Age or repeated immunization does not appear to affect the VH3-idiotypic immunogenicity of PPV among middle-aged and elderly adults. JF - Clinical and Vaccine Immunology AU - Serpa, Jose A AU - Valayam, Josemon AU - Musher, Daniel M AU - Rossen, Roger D AU - Pirofski, Liise-anne AU - Rodriguez-Barradas, Maria C AD - Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, maria.rodriguez-barradas2@va.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 362 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 18 IS - 3 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mortality KW - Age KW - Enzyme-linked immunosorbent assay KW - Serotypes KW - Lymphocytes B KW - Monoclonal antibodies KW - Antibody response KW - Polysaccharides KW - Vaccination KW - Morbidity KW - Streptococcus pneumoniae KW - Immunogenicity KW - Immunoglobulin G KW - Geriatrics KW - Vaccines KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869573270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=VH3+Antibody+Response+to+Immunization+with+Pneumococcal+Polysaccharide+Vaccine+in+Middle-Aged+and+Elderly+Persons&rft.au=Serpa%2C+Jose+A%3BValayam%2C+Josemon%3BMusher%2C+Daniel+M%3BRossen%2C+Roger+D%3BPirofski%2C+Liise-anne%3BRodriguez-Barradas%2C+Maria+C&rft.aulast=Serpa&rft.aufirst=Jose&rft.date=2011-03-01&rft.volume=18&rft.issue=3&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00408-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; Enzyme-linked immunosorbent assay; Age; Serotypes; Monoclonal antibodies; Lymphocytes B; Antibody response; Polysaccharides; Vaccination; Morbidity; Immunogenicity; Geriatrics; Immunoglobulin G; Vaccines; Streptococcus pneumoniae DO - http://dx.doi.org/10.1128/CVI.00408-10 ER - TY - JOUR T1 - Activity Preferences and Satisfaction Among Older Adults in a Veterans Administration Long-Term Care Facility AN - 868221251; 201111829 AB - Activities can be a nonpharmacological intervention for depression in long-term care. To address the activity needs of men, 183 residents of a VA long-term care facility were surveyed about activity interests, past and present, and activity satisfaction. With a 30% return rate, residents reported 85% overall satisfaction with activities and identified television as the most preferred activity, past and present. Bingo, movies, and listening to music ranked high for current activities. Prayer, reading, and pets increased in popularity. Current satisfaction with flea markets, pool, and gardening decreased from prior levels of satisfaction. Model making and arts and crafts activities were rated poorly. Long-term care facilities may want to expand television-based activities for older men in ways that promote increased socialization and mental activity. Adapted from the source document. JF - Clinical Gerontologist AU - Kracker, Jacqueline AU - Kearns, Kelly AU - Kier, Frederick J AU - Christensen, Kimberly A AD - James H. Quillen VAMC, P.O. Box 4000 (116B2), Mountain Home, TN 37684, USA E-mail: Jacqueline.Kracker@va.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 103 EP - 116 PB - Haworth Press/Taylor & Francis, Philadelphia PA VL - 34 IS - 2 SN - 0731-7115, 0731-7115 KW - activity preferences, long-term care, men, television KW - Long term care KW - Popularity KW - Music KW - Long term hospitals KW - Markets KW - Films KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868221251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Gerontologist&rft.atitle=Activity+Preferences+and+Satisfaction+Among+Older+Adults+in+a+Veterans+Administration+Long-Term+Care+Facility&rft.au=Kracker%2C+Jacqueline%3BKearns%2C+Kelly%3BKier%2C+Frederick+J%3BChristensen%2C+Kimberly+A&rft.aulast=Kracker&rft.aufirst=Jacqueline&rft.date=2011-03-01&rft.volume=34&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Clinical+Gerontologist&rft.issn=07317115&rft_id=info:doi/10.1080%2F07317115.2011.539522 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-05-18 N1 - Last updated - 2016-09-27 N1 - CODEN - CLGEDA N1 - SubjectsTermNotLitGenreText - Long term hospitals; Markets; Popularity; Long term care; Music; Films DO - http://dx.doi.org/10.1080/07317115.2011.539522 ER - TY - JOUR T1 - 2,4,6-Trinitrotoluene (TNT) air concentrations, hemoglobin changes, and anemia cases in respirator protected TNT munitions demilitarization workers AN - 860383540; 14368073 AB - Purpose: 2,4,6-Trinitrotoluene (TNT) is an explosive used in munitions production that is known to cause both aplastic and hemolytic anemia in exposed workers. Anemia in a TNT worker is considered a sentinel health event (occupational) (SHE(O)) in the United States (US). Deaths have been reported secondary to aplastic anemia. Studies have shown that TNT systemic absorption is significant by both the respiratory and dermal routes. No studies encountered looked at hemoglobin change or anemia cases in respiratory protected workers. It is hypothesized that respiratory protection is insufficient to protect TNT workers from the risk of anemia development and hemoglobin concentration drop. Methods: A records review of eight groups of respiratory protected TNT workers' pre-exposure hemoglobin levels were compared with their during-exposure hemoglobin levels for statistically significant (alpha level 0.05) hemoglobin level changes, and anemia cases were recorded. A curve estimation analysis was performed between mean TNT air concentrations and mean hemoglobin change values. Results: Statistically significant hemoglobin level drops and anemia cases were apparent at TNT air concentrations about the REL and PEL in respiratory protected workers. There were no anemia cases or statistically significant hemoglobin level drops at concentrations about the TLV, however. A statistically significant inverse non-linear regression model was found to be the best fit for regressing hemoglobin change on TNT air concentration. Conclusions: Respiratory protection may be inadequate to prevent workers who are at risk for TNT skin absorption from developing anemia. This study contributes evidence that the TLV should be considered for adoption as the new PEL. JF - International Archives of Occupational and Environmental Health AU - Bradley, Melville D AD - Patient Safety Fellow, Veterans Administration VISN 8 Patient Safety Center of Inquiry, James A. Haley Veterans Administration Medical Center, Tampa, FL, USA, Melville.bradley2@va.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 239 EP - 250 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 84 IS - 3 SN - 0340-0131, 0340-0131 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Mortality KW - anemia KW - Skin KW - Hemolytic anemia KW - Statistical analysis KW - Anemia KW - Adoption KW - 2,4,6-trinitrotoluene KW - Protective equipment KW - Models KW - Hemoglobin KW - Workers KW - USA KW - 2,4,6-Trinitrotoluene KW - Reviews KW - Absorption KW - Regression analysis KW - Explosives KW - Respirators KW - Aplastic anemia KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860383540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Archives+of+Occupational+and+Environmental+Health&rft.atitle=2%2C4%2C6-Trinitrotoluene+%28TNT%29+air+concentrations%2C+hemoglobin+changes%2C+and+anemia+cases+in+respirator+protected+TNT+munitions+demilitarization+workers&rft.au=Bradley%2C+Melville+D&rft.aulast=Bradley&rft.aufirst=Melville&rft.date=2011-03-01&rft.volume=84&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=International+Archives+of+Occupational+and+Environmental+Health&rft.issn=03400131&rft_id=info:doi/10.1007%2Fs00420-010-0559-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Skin; Hemolytic anemia; Anemia; Statistical analysis; Adoption; Models; Hemoglobin; Workers; 2,4,6-Trinitrotoluene; Regression analysis; Explosives; Aplastic anemia; Respirators; Mortality; anemia; Reviews; Absorption; 2,4,6-trinitrotoluene; Protective equipment; Occupational exposure; USA DO - http://dx.doi.org/10.1007/s00420-010-0559-6 ER - TY - JOUR T1 - Antenatal depression: a rationale for studying exercise AN - 1272690826; 15047417 AB - Background: Major depressive disorder (MDD) in pregnancy or antenatal depression poses unique treatment challenges and has serious consequences for mothers, unborn babies, and families when untreated. This review presents current knowledge on exercise during pregnancy, antidepressant effects of exercise, and the rationale for the specific study of exercise for antenatal depression. Method: A systematic literature review was performed using English language articles published in Medline, PsycINFO, CINAHL, and the Cochrane Library from 1985 to January 2010. Results: There is a broad literature supporting the antidepressant effects of exercise, but a paucity of studies specifically for antenatal depression. A small number of observational studies have reported that regular physical activities improve self-esteem and reduce symptoms of anxiety and depression during pregnancy. To date, there have not been randomized controlled studies of exercise for the treatment of MDD in pregnant women. Conclusions: Systematic studies are needed to assess exercise as a treatment alternative for MDD during pregnancy. In consideration of the benefits of exercise for the mother and baby, and the burden of depression, studies are needed to determine the role of exercise for pregnant women with depression. Depression and Anxiety 28:234-242,2011. [copy 2010 Wiley-Liss, Inc. JF - Depression and Anxiety AU - Shivakumarm S, Geetha AU - Brandonm S, Anna R AU - Snell, Peter G AU - Santiago-Munoz, Patricia AU - Johnson, Neysa L AU - Trivedi, Madhukar H AU - Freeman, Marlene P AD - Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, Geetha.Shivakumar@va.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 234 EP - 242 VL - 28 IS - 3 SN - 1091-4269, 1091-4269 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Depression KW - Anxiety KW - Physical activity KW - Women KW - Preschool children KW - Exercise KW - Knowledge KW - Physical training KW - Pregnancy KW - Antidepressants KW - Literature reviews KW - Family KW - Language KW - N3 11001:Behavioral and Cognitive Neuroscience KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1272690826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+Anxiety&rft.atitle=Antenatal+depression%3A+a+rationale+for+studying+exercise&rft.au=Shivakumarm+S%2C+Geetha%3BBrandonm+S%2C+Anna+R%3BSnell%2C+Peter+G%3BSantiago-Munoz%2C+Patricia%3BJohnson%2C+Neysa+L%3BTrivedi%2C+Madhukar+H%3BFreeman%2C+Marlene+P&rft.aulast=Shivakumarm+S&rft.aufirst=Geetha&rft.date=2011-03-01&rft.volume=28&rft.issue=3&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Depression+and+Anxiety&rft.issn=10914269&rft_id=info:doi/10.1002%2Fda.20777 L2 - http://onlinelibrary.wiley.com/doi/10.1002/da.20777/abstract LA - English DB - Physical Education Index N1 - Date revised - 2013-01-01 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Depression; Literature reviews; Anxiety; Women; Family; Preschool children; Exercise; Knowledge; Pregnancy; Antidepressants; Physical activity; Language; Physical training DO - http://dx.doi.org/10.1002/da.20777 ER - TY - JOUR T1 - An Evaluation of the Relation Between Distress Tolerance and Posttraumatic Stress within a Trauma-Exposed Sample AN - 1030905374; 201221756 AB - The present investigation examined the incremental associations between distress tolerance, or the perceived capacity to tolerate emotional distress, and global posttraumatic stress symptom severity as well as symptom cluster severity, beyond the variance accounted for by number of trauma exposure types and negative affectivity. The sample consisted of 140 adults (72 women; M age=25.9, SD=11.1) who endorsed exposure to traumatic life events, as defined by posttraumatic stress disorder diagnostic criterion A (American Psychiatric Association 2000). Participants did not meet diagnostic criteria for current axis I psychopathology. Distress tolerance demonstrated significant incremental associations with global posttraumatic stress symptom severity (p<.01) as well as re-experiencing (p<.05), avoidance (p=.05), and hyperarousal (p<.001) symptom cluster severity. Given the cross-sectional study design, causation cannot be inferred. Theoretical implications and future directions for better understanding associations between distress tolerance and posttraumatic stress are discussed. Adapted from the source document. JF - Journal of Psychopathology and Behavioral Assessment AU - Vujanovic, Anka A AU - Bonn-Miller, Marcel O AU - Potter, Carrie M AU - Marshall, Erin C AU - Zvolensky, Michael J AD - National Center for PTSD-Behavioral Science Division, VA Boston Healthcare System, 150 South Huntington Avenue (116B-2), Boston, MA, 02130, USA anka.vujanovic@va.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 129 EP - 135 PB - Springer, Dordrecht, The Netherlands VL - 33 IS - 1 SN - 0882-2689, 0882-2689 KW - Symptoms KW - Tolerance KW - Traumatic life events KW - Severity KW - Posttraumatic stress disorder KW - Psychological distress KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030905374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychopathology+and+Behavioral+Assessment&rft.atitle=An+Evaluation+of+the+Relation+Between+Distress+Tolerance+and+Posttraumatic+Stress+within+a+Trauma-Exposed+Sample&rft.au=Vujanovic%2C+Anka+A%3BBonn-Miller%2C+Marcel+O%3BPotter%2C+Carrie+M%3BMarshall%2C+Erin+C%3BZvolensky%2C+Michael+J&rft.aulast=Vujanovic&rft.aufirst=Anka&rft.date=2011-03-01&rft.volume=33&rft.issue=1&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychopathology+and+Behavioral+Assessment&rft.issn=08822689&rft_id=info:doi/10.1007%2Fs10862-010-9209-2 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JPBAEB N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Symptoms; Severity; Psychological distress; Tolerance; Traumatic life events DO - http://dx.doi.org/10.1007/s10862-010-9209-2 ER - TY - JOUR T1 - Research Integrity in Communication Sciences and Disorders: Preface AN - 993925976; 201203798 AB - Purpose: A joint program on Research on Research Integrity sponsored by the National Institute of Neurological Disorders and Stroke and the Office of Research Integrity encouraged the examination of practices and policies promoting the responsible conduct of research (RCR). The authors' grant -- Research Integrity in ASHA: Education and Publication -- enabled American Speech-Language-Hearing Association's (ASHA) Research Integrity Grant Group to (a) identify patterns of teaching and learning in Communication Sciences and Disorders graduate programs about specific topics of research integrity on the conduct of science, (b) examine perceptions about concepts of research integrity as they apply to scientific journals within the discipline, and (c) evaluate policies and practices established by ASHA to protect the integrity of published scientific work. Method: The authors reviewed historical and contemporary literature, conducted surveys, and analyzed ASHA policies. Conclusion: This supplement of the Journal of Speech, Language, and Hearing Research has been written with the aim of informing and inspiring scientists, students, research institutions, and professional societies to practice responsible research in the 21st century and beyond. Adapted from the source document JF - Journal of Speech, Language, and Hearing Research AU - Moss, Sharon E AD - American Speech-Language-Hearing Association, Rockville, MD sharon.moss2@va.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - S300 EP - 302S VL - 54 IS - 1 SN - 1092-4388, 1092-4388 KW - Ethics (22820) KW - Communication Disorders (13625) KW - Language Pathology (43250) KW - Hearing Disorders (31450) KW - Research Design (72950) KW - article KW - 4712: theory of linguistics; research design, methodology, and tools KW - 6410: language-pathological and normal; language and speech pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/993925976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=Research+Integrity+in+Communication+Sciences+and+Disorders%3A+Preface&rft.au=Moss%2C+Sharon+E&rft.aulast=Moss&rft.aufirst=Sharon&rft.date=2011-02-01&rft.volume=54&rft.issue=1&rft.spage=S300&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Communication Disorders (13625); Hearing Disorders (31450); Language Pathology (43250); Research Design (72950); Ethics (22820) ER - TY - JOUR T1 - Exogenous procalcitonin evokes a pro-inflammatory cytokine response AN - 907151040; 14263988 AB - Objective and design: Procalcitonin (ProCT) is increased in serum of septic patients and those with systemic inflammation. Endogenous levels of ProCT might influence the response of polymorphonuclear leukocytes (PMNs), independently of endotoxin, in clinical disease. Subjects: Healthy human volunteers. Treatment: Recombinant human ProCT (rhProCT). Methods: Whole blood and PMNs were exposed invitro to exogenous rhProCT. Interleukin (IL)-6, IL-8, IL-10, IL-13, tumor necrosis factor-alpha (TNF alpha ), IL-1 beta , and macrophage inflammatory protein (MIP)-1 beta (pg/ml) were measured by multiplex suspension bead-array immunoassay, and migration and phagocytosis were measured in PMNs. Results: In a whole-blood model, a dose-dependent increase in IL-6, TNF alpha , and IL-1 beta of the cell-free supernatant was noted. Pre-incubation with ProCT, at doses consistent with clinical sepsis, resulted in a decrease in PMN migration without alteration in phagocytosis of Staphylococcus aureus or indirect measurements of bacterial killing. Conclusion: Clinically relevant levels of ProCT influence immunologic responses that may contribute to systemic inflammatory response and septic shock. JF - Inflammation Research AU - Liappis, Angelike P AU - Gibbs, Kevin W AU - Nylen, Eric S AU - Yoon, Bona AU - Snider, Richard H AU - Gao, Baochong AU - Becker, Kenneth L AD - Medical Service and Section of Infectious Diseases, Veterans Affairs Medical Center, 50 Irving Street, NW 4A155, Washington, DC, USA, angelike.liappis@va.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 203 EP - 207 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 60 IS - 2 SN - 1023-3830, 1023-3830 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Endotoxins KW - Interleukin 6 KW - Leukocytes (polymorphonuclear) KW - Interleukin 1 KW - Septic shock KW - Interleukin 10 KW - Interleukin 8 KW - Inflammation KW - Leukocyte migration KW - Blood KW - Interleukin 13 KW - Sepsis KW - Cytokines KW - procalcitonin KW - Tumor necrosis factor- alpha KW - Staphylococcus aureus KW - Macrophage inflammatory protein KW - Phagocytosis KW - Immunoassays KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907151040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inflammation+Research&rft.atitle=Exogenous+procalcitonin+evokes+a+pro-inflammatory+cytokine+response&rft.au=Liappis%2C+Angelike+P%3BGibbs%2C+Kevin+W%3BNylen%2C+Eric+S%3BYoon%2C+Bona%3BSnider%2C+Richard+H%3BGao%2C+Baochong%3BBecker%2C+Kenneth+L&rft.aulast=Liappis&rft.aufirst=Angelike&rft.date=2011-02-01&rft.volume=60&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Inflammation+Research&rft.issn=10233830&rft_id=info:doi/10.1007%2Fs00011-010-0255-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Endotoxins; Leukocytes (polymorphonuclear); Interleukin 1; Septic shock; Interleukin 8; Interleukin 10; Inflammation; Leukocyte migration; Blood; Sepsis; Interleukin 13; Cytokines; Tumor necrosis factor- alpha; procalcitonin; Phagocytosis; Macrophage inflammatory protein; Immunoassays; Staphylococcus aureus DO - http://dx.doi.org/10.1007/s00011-010-0255-8 ER - TY - JOUR T1 - Attention to Hierarchical Level Influences Attentional Selection of Spatial Scale AN - 896228050; 201116746 AB - Ample evidence suggests that global perception may involve low spatial frequency (LSF) processing and that local perception may involve high spatial frequency (HSF) processing (Shulman, Sullivan, Gish, & Sakoda, 1986; Shulman & Wilson, 1987; Robertson, 1996). It is debated whether SF selection is a low-level mechanism associating global and local information with absolute LSF and HSF content, or whether it is a higher level mechanism involving a selective process that defines the SF range in which global and local can then be relatively defined. The present study provides support for the latter claim by demonstrating that allocating attention to global or local levels of hierarchical displays biased selection of LSFs or HSFs, respectively, in subsequently presented compound gratings. This bias occurred despite a change in the response dimension (from letter identification in the hierarchical stimulus to orientation discrimination in the grating) and despite a difference in retinal location of the hierarchical stimuli and the grating stimulus. Moreover, the bias was determined by the relationship between the 2 SFs in the compound grating (i.e., their relative frequency) rather than the absolute SF values. [Copyright American Psychological Association] JF - Journal of Experimental Psychology: Human Perception and Performance AU - Flevaris, Anastasia V AU - Bentin, Shlomo AU - Robertson, Lynn C AD - Department of Psychology, University of California at Berkeley, and Veterans Administration Center, Martinez, CA Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 12 EP - 22 PB - American Psychological Association, Washington DC VL - 37 IS - 1 SN - 0096-1523, 0096-1523 KW - hierarchical perception selective attention spatial frequency KW - Displays KW - Stimulus KW - Discrimination KW - Identification KW - Bias KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896228050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Psychology%3A+Human+Perception+and+Performance&rft.atitle=Attention+to+Hierarchical+Level+Influences+Attentional+Selection+of+Spatial+Scale&rft.au=Flevaris%2C+Anastasia+V%3BBentin%2C+Shlomo%3BRobertson%2C+Lynn+C&rft.aulast=Flevaris&rft.aufirst=Anastasia&rft.date=2011-02-01&rft.volume=37&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Psychology%3A+Human+Perception+and+Performance&rft.issn=00961523&rft_id=info:doi/10.1037%2Fa0019251 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - CODEN - JPHPDH N1 - SubjectsTermNotLitGenreText - Stimulus; Bias; Identification; Displays; Discrimination DO - http://dx.doi.org/10.1037/a0019251 ER - TY - JOUR T1 - Stem cell antigen-1 positive cell-based systemic human growth hormone gene transfer strategy increases endosteal bone resorption and bone loss in mice AN - 883034615; 15246672 AB - Background The present study assesses the effect of the stem cell antigen-1 positive (Sca-1+) cell-based human growth hormone (hGH) ex vivo gene transfer strategy on endosteal bone mass in the mouse. Methods Sublethally irradiated recipient mice were transplanted with Sca-1+ cells transduced with lentiviral vectors expressing hGH or beta -galactosidase control genes. Bone parameters were assessed by micro-computed tomography and histomorphometry. Results This hGH strategy drastically increased hGH mRNA levels in bone marrow cells and serum insulin-like growth factor-I (IGF-I) (by nearly 50%, p < 0.002) in hGH recipient mice. Femoral trabecular bone volume of the hGH mice was significantly reduced by 35% (p < 0.002). The hGH mice also had decreased trabecular number (by 26%; p < 0.0001), increased trabecular separation (by 38%; p < 0.0002) and reduced trabecular connectivity density (by 64%; p < 0.001), as well as significantly more osteoclasts (2.5-fold; p < 0.05) and greater osteoclastic surface per bone surface (2.6-fold; p < 0.01). Conclusions Targeted expression of hGH in cells of marrow cavity through the Sca-1+ cell-based gene transfer strategy increased circulating IGF-I and decreased endosteal bone mass through an increase in resorption in recipient mice. These results indicate that high local levels of hGH or IGF-I in the bone marrow microenvironment enhanced resorption, which is consistent with previous findings in transgenic mice with targeted bone IGF-I expression showing that high local IGF-I expression increased bone remodeling, favoring a net bone loss. Thus, GH and/or IGF-I would not be an appropriate transgene for use in this Sca-1+ cell-based gene transfer strategy to promote endosteal bone formation. Published 2011 John Wiley & Sons, Ltd. JF - Journal of Gene Medicine AU - Hall, Susan L AU - Chen, Shin-Tai AU - Wergedal, Jon E AU - Gridley, Daila S AU - Mohan, Subburaman AU - Lau, K-H William AD - Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA, USA, susan.hall1@va.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 77 EP - 88 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 13 IS - 2 SN - 1521-2254, 1521-2254 KW - Calcium & Calcified Tissue Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Bone (trabecular) KW - Bone histomorphometry KW - Bone loss KW - Bone marrow KW - Bone mass KW - Bone remodelling KW - Bone resorption KW - Computed tomography KW - Femur KW - Gene transfer KW - Growth hormone KW - Insulin-like growth factor I KW - Microenvironments KW - Osteoclasts KW - Osteogenesis KW - Stem cells KW - Transgenes KW - Transgenic mice KW - beta -Galactosidase KW - mRNA KW - T 2050:Genetics KW - G 07730:Development & Cell Cycle KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883034615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gene+Medicine&rft.atitle=Stem+cell+antigen-1+positive+cell-based+systemic+human+growth+hormone+gene+transfer+strategy+increases+endosteal+bone+resorption+and+bone+loss+in+mice&rft.au=Hall%2C+Susan+L%3BChen%2C+Shin-Tai%3BWergedal%2C+Jon+E%3BGridley%2C+Daila+S%3BMohan%2C+Subburaman%3BLau%2C+K-H+William&rft.aulast=Hall&rft.aufirst=Susan&rft.date=2011-02-01&rft.volume=13&rft.issue=2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gene+Medicine&rft.issn=15212254&rft_id=info:doi/10.1002%2Fjgm.1542 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jgm.1542/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Insulin-like growth factor I; Growth hormone; beta -Galactosidase; Osteoclasts; Transgenes; Bone marrow; Bone histomorphometry; Transgenic mice; Femur; mRNA; Bone (trabecular); Stem cells; Gene transfer; Computed tomography; Bone loss; Microenvironments; Bone resorption; Bone mass; Bone remodelling; Osteogenesis DO - http://dx.doi.org/10.1002/jgm.1542 ER - TY - JOUR T1 - Facilitating Practice Changes in Mental Health Clinics: A Guide for Implementation Development in Health Care Systems AN - 875712669; 201113129 AB - For more than a decade, health care systems have attempted to implement evidence-based practices and guidelines. These efforts have demonstrated the difficulty in making practice changes in complex systems of care. Many health care systems, including the Department of Veterans Affairs (VA) and state community mental health systems, have made adoption of evidence-based treatments, especially psychotherapies, a priority. Psychologists, as behavioral change experts and clinical leaders, are positioned to aid local implementation efforts but may have limited knowledge of the "implementation science" literature. This article provides a brief introduction to the implementation literature and offers a guide for developing an implementation plan to adopt evidence-based psychotherapies in local health care settings illustrated by a hypothetical example. Challenges to implementation are discussed. [Copyright Elsevier B.V.] JF - Psychological Services AU - Kauth, Michael R AU - Sullivan, Greer AU - Cully, Jeffrey AU - Blevins, Dean AD - South Central Mental Illness Research, Education, and Clinical Center (SC-MIRECC), Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas michael.kauth@va.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 36 EP - 47 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 8 IS - 1 SN - 1541-1559, 1541-1559 KW - implementation dissemination evidence-based practices facilitation change KW - Mental health services KW - Health care KW - Psychotherapy KW - Clinics KW - Clinical psychologists KW - Evidence based medicine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875712669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Facilitating+Practice+Changes+in+Mental+Health+Clinics%3A+A+Guide+for+Implementation+Development+in+Health+Care+Systems&rft.au=Kauth%2C+Michael+R%3BSullivan%2C+Greer%3BCully%2C+Jeffrey%3BBlevins%2C+Dean&rft.aulast=Kauth&rft.aufirst=Michael&rft.date=2011-02-01&rft.volume=8&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0022250 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-07-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Health care; Psychotherapy; Evidence based medicine; Clinics; Clinical psychologists; Mental health services DO - http://dx.doi.org/10.1037/a0022250 ER - TY - JOUR T1 - Pretreatment Predictors of Dropout From Cognitive Behavioral Therapy for PTSD in Iraq and Afghanistan War Veterans AN - 875712335; 201113010 AB - Cognitive-behavioral therapies (CBTs) can be effective treatments for posttraumatic stress disorder (PTSD) but their effectiveness is limited by high rates of premature dropout. Few studies have compared pretreatment characteristics of treatment completers and dropouts, and only one has examined these factors in Operations Iraqi Freedom and Enduring Freedom (OIF/OEF) Veterans. This study analyzed archival clinical data from 117 OEF/OIF Veterans evaluated and treated through a Veterans Affairs PTSD clinic. High numbers dropped out of treatment (68%). Treatment dropouts (n = 79) and completers (n = 38) differed significantly on Minnesota Multiphasic Personality Inventory-2 (MMPI-2) scales, PTSD symptom severity, and age. Regression analyses identified one MMPI-2 scale, TRT (negative treatment indicators), and age as unique but modest predictors of dropout. [Copyright Elsevier B.V.] JF - Psychological Services AU - Garcia, Hector A AU - Kelley, Lance P AU - Rentz, Timothy O AU - Lee, Shuko AD - Veterans Administration Medical Center, San Antonio, TX Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 1 EP - 11 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 8 IS - 1 SN - 1541-1559, 1541-1559 KW - posttraumatic stress disorder (PTSD) Operation Enduring Freedom (OEF)/Operation Iraqi Freedom (OIF) dropout MMPI-2 predictors KW - Veterans KW - Cognitive behaviour therapy KW - Minnesota Multiphasic Personality Inventory-2 KW - Posttraumatic stress disorder KW - Dropping out KW - Freedom KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875712335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Pretreatment+Predictors+of+Dropout+From+Cognitive+Behavioral+Therapy+for+PTSD+in+Iraq+and+Afghanistan+War+Veterans&rft.au=Garcia%2C+Hector+A%3BKelley%2C+Lance+P%3BRentz%2C+Timothy+O%3BLee%2C+Shuko&rft.aulast=Garcia&rft.aufirst=Hector&rft.date=2011-02-01&rft.volume=8&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0022705 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-07-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Dropping out; Posttraumatic stress disorder; Veterans; Cognitive behaviour therapy; Minnesota Multiphasic Personality Inventory-2; Freedom DO - http://dx.doi.org/10.1037/a0022705 ER - TY - JOUR T1 - Prevalence and Natural History of Neuropsychiatric Syndromes in Veteran Hospice Patients AN - 870995747; 201112258 AB - Context Prospective studies are needed to adequately describe the overall impact of neuropsychiatric syndromes on the course of hospice enrollment in outpatient settings. Objectives. To determine the prevalence and natural history of delirium, cognitive impairment, alcohol abuse, anxiety, depression, and suicidal ideation (SI) in community-dwelling veteran hospice patients. Methods. Home hospice patients were visited regularly from enrollment until their deaths, study withdrawal, or discharge from hospice. Family caregivers gave consent for those with Mini-Mental State Examination (MMSE) scores less than or equal to 23. Measures included the Structured Clinical Interview for DSM-IV for depression (past and current) and alcohol abuse; the Hospital Anxiety and Depression Scale; MMSE; and Confusion Assessment Method (CAM). A clinician-rated CAM item documented sleep disturbance, and participants were asked about SI at each visit. Results. The median length of hospice enrollment was 81 days. Of 88 participants, 77 (88%) experienced at least one neuropsychiatric syndrome. Cognitive impairment was prevalent, with 60 (68%) registering MMSE less than or equal to 23 at least once. More than half of the participants developed delirium; the proportion with delirium, any cognitive impairment, sleep disturbance, or any neuropsychiatric syndrome increased significantly from first to last study visit. Twelve (14%) participants had SI during the study, and 30 (34%) participants were affected by depression overall. Sixteen patients who were not depressed on admission subsequently developed depression. Anxiety was present in 14 (16%) on at least one study visit. Active alcohol abuse remained relatively stable (8%) across visits. Conclusions. Psychiatric syndromes are highly prevalent in hospice patients. Systematic case finding of psychiatric disorders may be necessary to improve quality of life in the last months of life. [Copyright U.S. Cancer Pain Relief Committee. Published by Elsevier Inc.] JF - Journal of Pain and Symptom Management AU - Goy, Elizabeth R AU - Ganzini, Linda AD - Mental Health Division and Health Services Research and Development Program, R&D 66, Portland Veterans Affairs Medical Center, P.O. Box 1034, Portland, OR 97207, USA E-mail: linda.ganzini@va.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 394 EP - 401 PB - Elsevier, New York NY VL - 41 IS - 2 SN - 0885-3924, 0885-3924 KW - Hospice, veterans, mental disorders, anxiety, depression, suicide, delirium, alcohol abuse, insomnia KW - Hospices KW - Minimental State Examination KW - Enrollment KW - Cognitive impairment KW - Delirium KW - Anxiety-Depression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870995747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pain+and+Symptom+Management&rft.atitle=Prevalence+and+Natural+History+of+Neuropsychiatric+Syndromes+in+Veteran+Hospice+Patients&rft.au=Goy%2C+Elizabeth+R%3BGanzini%2C+Linda&rft.aulast=Goy&rft.aufirst=Elizabeth&rft.date=2011-02-01&rft.volume=41&rft.issue=2&rft.spage=394&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pain+and+Symptom+Management&rft.issn=08853924&rft_id=info:doi/10.1016%2Fj.jpainsymman.2010.04.015 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-06-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JSPME2 N1 - SubjectsTermNotLitGenreText - Anxiety-Depression; Hospices; Minimental State Examination; Cognitive impairment; Enrollment; Delirium DO - http://dx.doi.org/10.1016/j.jpainsymman.2010.04.015 ER - TY - JOUR T1 - Posttraumatic Stress Disorder and Intimate Relationship Problems: A Meta-Analysis AN - 855901029; 201108347 AB - Objective: The authors conducted a meta-analysis of empirical studies investigating associations between indices of posttraumatic stress disorder (PTSD) and intimate relationship problems to empirically synthesize this literature. Method: A literature search using PsycINFO, Medline, Published International Literature on Traumatic Stress (PILOTS), and Dissertation Abstracts was performed. The authors identified 31 studies meeting inclusion criteria. Results: True score correlations (rho) revealed medium-sized associations between PTSD and intimate relationship discord (rho = .38, N = 7,973, K = 21), intimate relationship physical aggression perpetration (rho = .42, N = 4,630, K = 19), and intimate relationship psychological aggression perpetration (rho = .36, N = 1,501, K = 10). The strength of the association between PTSD and relationship discord was higher in military (vs. civilian) samples, and when the study was conducted in the United States (vs. other country), and the study represented a doctoral dissertation (vs. published article). The strength of the association between PTSD and physical aggression was higher in military (vs. civilian) samples, males (vs. females), community (vs. clinical) samples, studies examining PTSD symptom severity (vs. diagnosis), when the physical aggression measure focused exclusively on severe violence (vs. a more inclusive measure), and the study was published (vs. dissertation). For the PTSD-psychological aggression association, 98% of the variance was accounted for by methodological artifacts such as sampling and measurement error; consequently, no moderators were examined in this relationship. Conclusions: Findings highlight a need for the examination of models explaining the relationship difficulties associated with PTSD symptomatology and interventions designed to treat problems in both areas. [Copyright American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Taft, Casey T AU - Watkins, Laura E AU - Street, Amy E AU - Monson, Candice M Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 22 EP - 33 PB - American Psychological Association, Washington DC VL - 79 IS - 1 SN - 0022-006X, 0022-006X KW - PTSD intimate relationships couples trauma KW - Posttraumatic stress disorder KW - Dissertations KW - Sampling KW - Aggression KW - Intimate relationships KW - Moderators KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855901029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=Posttraumatic+Stress+Disorder+and+Intimate+Relationship+Problems%3A+A+Meta-Analysis&rft.au=Taft%2C+Casey+T%3BWatkins%2C+Laura+E%3BStreet%2C+Amy+E%3BMonson%2C+Candice+M&rft.aulast=Taft&rft.aufirst=Casey&rft.date=2011-02-01&rft.volume=79&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2Fa0022196 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-03-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Intimate relationships; Aggression; Dissertations; Moderators; Sampling DO - http://dx.doi.org/10.1037/a0022196 ER - TY - JOUR T1 - Movement disorders induced by antipsychotic drugs: implications of the CATIE schizophrenia trial. AN - 820793001; 21172575 AB - Drug-induced movement disorders have dramatically declined with the widespread use of second-generation antipsychotics, but remain important in clinical practice and for understanding antipsychotic pharmacology. The diagnosis and management of dystonia, parkinsonism, akathisia, catatonia, neuroleptic malignant syndrome, and tardive dyskinesia are reviewed in relation to the decreased liability of the second-generation antipsychotics contrasted with evidence from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Schizophrenia Trial. Data from the CATIE trial imply that advantages of second-generation antipsychotics in significantly reducing extrapyramidal side effects compared with haloperidol may be diminished when compared with modest doses of lower-potency first-generation drugs. Published by Elsevier Inc. JF - Neurologic clinics AU - Caroff, Stanley N AU - Hurford, Irene AU - Lybrand, Janice AU - Campbell, E Cabrina AD - Department of Psychiatry, Veterans Affairs Medical Center-116A, University & Woodland Avenues, Philadelphia, PA 19104, USA. stanley.caroff@va.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 127 EP - 48, viii VL - 29 IS - 1 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Humans KW - Movement Disorders -- classification KW - Movement Disorders -- etiology KW - Clinical Trials as Topic KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/820793001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurologic+clinics&rft.atitle=Movement+disorders+induced+by+antipsychotic+drugs%3A+implications+of+the+CATIE+schizophrenia+trial.&rft.au=Caroff%2C+Stanley+N%3BHurford%2C+Irene%3BLybrand%2C+Janice%3BCampbell%2C+E+Cabrina&rft.aulast=Caroff&rft.aufirst=Stanley&rft.date=2011-02-01&rft.volume=29&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Neurologic+clinics&rft.issn=1557-9875&rft_id=info:doi/10.1016%2Fj.ncl.2010.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-14 N1 - Date created - 2010-12-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Psychiatry. 2004 Mar;161(3):414-25 [14992963] Pharmacopsychiatry. 2004 Mar;37 Suppl 1:S54-64 [15052515] Acta Psychiatr Scand Suppl. 1970;212:11-9 [4917967] Neuropsychopharmacology. 1999 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Psychiatry. 2000;61 Suppl 4:27-32 [10739328] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ncl.2010.10.002 ER - TY - JOUR T1 - Systemic Vulnerabilities to Suicide among Veterans from the Iraq and Afghanistan Conflicts: Review of Case Reports from a National Veterans Affairs Database AN - 1429625636; 201336363 AB - While suicide among recently returned veterans is of great concern, it is a relatively rare occurrence within individual hospitals and clinics. Root cause analysis (RCA) generates a detailed case report that can be used to identify system-based vulnerabilities following an adverse event. Review of a national database of RCA reports may identify common vulnerabilities and assist in the development of more robust prevention strategies. Our objective was to identify and compare common themes among reports of suicide among veterans of Operations Iraqi Freedom and Enduring Freedom (OIF/OEF) in the Veterans Affairs system. Common themes among root causes of suicide as identified in RCA reports were collected and compared as the primary outcome -- systematic vulnerabilities. Actions recommended within the reports were coded as the secondary outcome -- prevention strategies. Fifty-one RCA reports of OIF/OEF suicides were identified by our search. Coding generated 16 common categories among 132 root causes, and 13 categories among 108 recommended actions. Assessment of suicidal risk, coordination of care, timely access to care, and communication among providers were the most common root causes. Actions identified by RCA teams to reduce suicide included improving referral processes, staff education in suicide assessment, and follow-up with suicidal veterans. Review of multiple RCA reports can identify organizational vulnerabilities detected at the local level that may be applicable system wide. Attention to improving suicide assessment, coordination of care, and timely access may have the largest impact on reducing suicide among OIF/OEF veterans. Adapted from the source document. JF - Suicide and Life-Threatening Behavior AU - Mills, Peter D AU - Huber, Samuel J AU - Watts, Bradley Vince AU - Bagian, James P Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 21 EP - 32 PB - John Wiley & Sons, Inc. VL - 41 IS - 1 SN - 0363-0234, 0363-0234 KW - Veterans KW - Prevention KW - Freedom KW - Suicide KW - Access KW - Vulnerability KW - Conflict KW - Iraq KW - Hospitals KW - article KW - 0623: complex organization; military sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1429625636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Suicide+and+Life-Threatening+Behavior&rft.atitle=Systemic+Vulnerabilities+to+Suicide+among+Veterans+from+the+Iraq+and+Afghanistan+Conflicts%3A+Review+of+Case+Reports+from+a+National+Veterans+Affairs+Database&rft.au=Mills%2C+Peter+D%3BHuber%2C+Samuel+J%3BWatts%2C+Bradley+Vince%3BBagian%2C+James+P&rft.aulast=Mills&rft.aufirst=Peter&rft.date=2011-02-01&rft.volume=41&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Suicide+and+Life-Threatening+Behavior&rft.issn=03630234&rft_id=info:doi/10.1111%2Fj.1943-278X.2010.00012.x LA - English DB - Sociological Abstracts N1 - Date revised - 2013-09-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SLBEDP N1 - SubjectsTermNotLitGenreText - Suicide; Veterans; Vulnerability; Freedom; Access; Prevention; Iraq; Hospitals; Conflict DO - http://dx.doi.org/10.1111/j.1943-278X.2010.00012.x ER - TY - JOUR T1 - Mindfulness in the treatment of posttraumatic stress disorder among military veterans. AN - 1023097680; 201219166 AB - How might a practice that has its roots in contemplative traditions, seeking heightened awareness through meditation, apply to trauma-related mental health struggles among military veterans? In recent years, clinicians and researchers have observed the increasing presence of mindfulness in Western mental health treatment programs. Mindfulness is about bringing an attitude of curiosity and compassion to present experience. This review addresses the above question in a detailed manner with an emphasis on the treatment of military veterans suffering from posttraumatic stress disorder (PTSD) and related psychopathology. In addition, the integration of mindfulness with current empirically supported treatments for PTSD is discussed with specific attention to directions for future research in this area. [Copyright Elsevier B.V.] JF - Professional Psychology: Research and Practice AU - Vujanovic, Anka A AU - Niles, Barbara AU - Pietrefesa, Ashley AU - Schmertz, Stefan K AU - Potter, Carrie M AD - National Center for PTSD-Behavioral Science Division, VA Boston Healthcare System anka.vujanovic@va.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 24 EP - 31 PB - American Psychological Association, Washington DC VL - 42 IS - 1 SN - 0735-7028, 0735-7028 KW - military veterans KW - mindfulness KW - posttraumatic stress disorder KW - treatment KW - Suffering KW - Veterans KW - Posttraumatic stress disorder KW - Awareness KW - Treatment methods KW - Traditions KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023097680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Psychology%3A+Research+and+Practice&rft.atitle=Mindfulness+in+the+treatment+of+posttraumatic+stress+disorder+among+military+veterans.&rft.au=Vujanovic%2C+Anka+A%3BNiles%2C+Barbara%3BPietrefesa%2C+Ashley%3BSchmertz%2C+Stefan+K%3BPotter%2C+Carrie+M&rft.aulast=Vujanovic&rft.aufirst=Anka&rft.date=2011-02-01&rft.volume=42&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Professional+Psychology%3A+Research+and+Practice&rft.issn=07357028&rft_id=info:doi/10.1037%2Fa0022272 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Awareness; Veterans; Suffering; Traditions; Treatment methods DO - http://dx.doi.org/10.1037/a0022272 ER - TY - JOUR T1 - Multifamily group treatment for veterans with traumatic brain injury AN - 1023096044; 201217398 AB - A common clinical problem encountered by clinicians treating veterans who incurred traumatic brain injury (TBI) while serving in Afghanistan in support of Operation Enduring Freedom (OEF) or in Iraq in support of Operation Iraqi Freedom (OIF) is lack of knowledge about TBI on the part of the veterans' family members. Insufficient information can exacerbate marital or family conflict and lead to psychological distress and social isolation for the veteran and family, and suboptimal illness management for the veteran. To address this problem, we adapted Multifamily Group Treatment (MFGT), an evidence-based practice for treatment of serious mental illness (SMI), for treatment of OEF/OIF veterans with TBI and their families. We have implemented the adapted treatment (MFG-TBI) in four groups of veterans and families (N = 20 veterans and 20 family members) across two sites: the Durham VA Medical Center (VAMC) in North Carolina and the JJ Peters VAMC in the Bronx, New York. Adaptations focused on contents and format of the educational components, specification of a protocol for conjugal couples, and the addition of an ecomap to identify support systems during the joining (i.e. assessment) phase, a shorter (9 months) intervention duration, and a more active clinician role including use of motivational enhancement, intersession support, and coordination with other service providers. Biweekly group sessions were supervised and rated for adherence. We illustrate how MFG-TBI both educates and builds problem-solving skills with clinical examples. Suggestions for effective use of problem-solving skills with this population are offered. [Copyright Elsevier B.V.] JF - Professional Psychology: Research and Practice AU - Perlick, Deborah A AU - Straits-Troster, Kristy AU - Dyck, Dennis G AU - Norell, Diane M AU - Strauss, Jennifer L AU - Henderson, Claire AU - Close, Joy AU - Berger, Noelle AU - Bonuck, Elizabeth R AU - Taber, Katherine H AU - Kalvin, Carla AU - Dolber, Trygve AU - Cristian, Adrian AD - JJ Peters Department of Veterans Affairs Medical Center deborah.perlick@va.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 70 EP - 78 PB - American Psychological Association, Washington DC VL - 42 IS - 1 SN - 0735-7028, 0735-7028 KW - combat veterans KW - multifamily group KW - traumatic brain injury KW - evidence-based practice KW - psychoeducation KW - problem solving KW - couples KW - Group therapy KW - Veterans KW - Problem solving KW - Freedom KW - Relatives KW - Traumatic brain injury KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023096044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Psychology%3A+Research+and+Practice&rft.atitle=Multifamily+group+treatment+for+veterans+with+traumatic+brain+injury&rft.au=Perlick%2C+Deborah+A%3BStraits-Troster%2C+Kristy%3BDyck%2C+Dennis+G%3BNorell%2C+Diane+M%3BStrauss%2C+Jennifer+L%3BHenderson%2C+Claire%3BClose%2C+Joy%3BBerger%2C+Noelle%3BBonuck%2C+Elizabeth+R%3BTaber%2C+Katherine+H%3BKalvin%2C+Carla%3BDolber%2C+Trygve%3BCristian%2C+Adrian&rft.aulast=Perlick&rft.aufirst=Deborah&rft.date=2011-02-01&rft.volume=42&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Professional+Psychology%3A+Research+and+Practice&rft.issn=07357028&rft_id=info:doi/10.1037%2Fa0022319 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Veterans; Freedom; Relatives; Group therapy; Traumatic brain injury; Problem solving DO - http://dx.doi.org/10.1037/a0022319 ER - TY - JOUR T1 - Partnering With Communities to Address the Mental Health Needs of Rural Veterans AN - 964245139; 2011-191150 AB - Purpose: Many veterans who face mental illness and live in rural areas never obtain the mental health care they need. To address these needs, it is important to reach out to community stakeholders who are likely to have frequent interactions with veterans, particularly those returning from Operations Enduring and Iraqi Freedom (OEF/OIF). Methods: Three community stakeholder groups-clergy, postsecondary educators, and criminal justice personnel-are of particular importance for OEF/OIF veterans living in rural areas and may be more likely to come into contact with rural veterans struggling with mental illness or substance abuse than the formal health care system. This article briefly describes the conceptualization, development, initial implementation, and early evaluation of a Veterans Affairs (VA) medical center-based program designed to improve engagement in, and access to, mental health care for veterans returning to rural areas. Findings: One year since initial funding, 90 stakeholders have attended formal training workshops (criminal justice personnel = 36; educators = 31; clergy = 23). Two training formats (a 2-hour workshop and an intensive 2.5-day workshop) have been developed and provided to clergy in 1 rural county with another county scheduled for training. A veteran outreach initiative, which has received 32 referrals for various student services, has been established on 4 rural college campuses. A Veterans Treatment Court also has been established with 16 referrals for eligibility assessments. Conclusions: While this pilot program is in the early stages of evaluation, its success to date has encouraged program and VA clinical leadership to expand beyond the original sites. Adapted from the source document. JF - The Journal of Rural Health AU - Kirchner, JoAnn E AU - Farmer, Mary Sue AU - Shue, Valorie M AU - Blevins, Dean AU - Sullivan, Greer AD - United States Department of Veterans Affairs Mental Health Quality Enhancement Research Initiative, North Little Rock, Arkansas Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 416 EP - 424 PB - National Rural Health Association, Kansas City MO VL - 27 IS - 4 SN - 0890-765X, 0890-765X KW - Health conditions and policy - Health and health policy KW - Social conditions and policy - Rural conditions KW - Military and defense policy - Military personnel and veterans KW - Health conditions and policy - Diseases and disorders KW - Social conditions and policy - Drinking, smoking, and drug addiction KW - United States KW - Veterans KW - Mental illness KW - Rural conditions KW - Mental health KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964245139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health&rft.atitle=Partnering+With+Communities+to+Address+the+Mental+Health+Needs+of+Rural+Veterans&rft.au=Kirchner%2C+JoAnn+E%3BFarmer%2C+Mary+Sue%3BShue%2C+Valorie+M%3BBlevins%2C+Dean%3BSullivan%2C+Greer&rft.aulast=Kirchner&rft.aufirst=JoAnn&rft.date=2011-01-01&rft.volume=27&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2011.00362.x LA - English DB - PAIS Index N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JRHEEX N1 - SubjectsTermNotLitGenreText - Mental health; Rural conditions; Veterans; Mental illness; Substance abuse; United States DO - http://dx.doi.org/10.1111/j.1748-0361.2011.00362.x ER - TY - JOUR T1 - Variables associated with odds of finishing and finish time in a 161-km ultramarathon AN - 954616797; 14167699 AB - We sought to determine the degree to which age, sex, calendar year, previous event experience and ambient race day temperature were associated with finishing a 100-mile (161-km) trail running race and with finish time in that race. We computed separate generalized linear mixed-effects regression models for (1) odds of finishing and (2) finish times of finishers. Every starter from 1986 to 2007 was used in computing the models for odds of finishing (8,282 starts by 3,956 individuals) and every finisher in the same period was included in the models for finish time (5,276 finishes). Factors associated with improved odds of finishing included being a first-time starter and advancing calendar year. Factors associated with reduced odds of finishing included advancing age above 38years and warmer weather. Beyond 38years of age, women had worse odds of finishing than men. Warmer weather had a similar effect on finish rates for men and women. Finish times were slower with advancing age, slower for women than men, and less affected by warm weather for women than for men. Calendar year was not associated with finish time after adjustment for other variables. JF - European Journal of Applied Physiology AU - Wegelin, Jacob A AU - Hoffman, Martin D AD - Department of Physical Medicine and Rehabilitation, Department of Veterans Affairs, Northern California Health Care System, and University of California Davis Medical Center, 10535 Hospital Way (117), Sacramento, CA, 95655-1200, USA, martin.hoffman@va.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 145 EP - 153 PB - Springer-Verlag, P.O. Box 2485 Secaucus NJ 07096-2485 USA VL - 111 IS - 1 SN - 1439-6319, 1439-6319 KW - Physical Education Index KW - Weather KW - Experience KW - Ultramarathon KW - Starts KW - Men KW - Women KW - Running (racing) KW - Sex determination KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954616797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Applied+Physiology&rft.atitle=Variables+associated+with+odds+of+finishing+and+finish+time+in+a+161-km+ultramarathon&rft.au=Wegelin%2C+Jacob+A%3BHoffman%2C+Martin+D&rft.aulast=Wegelin&rft.aufirst=Jacob&rft.date=2011-01-01&rft.volume=111&rft.issue=1&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Applied+Physiology&rft.issn=14396319&rft_id=info:doi/10.1007%2Fs00421-010-1633-1 LA - English DB - Physical Education Index N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Experience; Weather; Ultramarathon; Starts; Men; Women; Running (racing); Sex determination DO - http://dx.doi.org/10.1007/s00421-010-1633-1 ER - TY - JOUR T1 - Speed- and cane-related alterations in gait parameters in individuals with multiple sclerosis AN - 954610246; 14183886 AB - Previous literature reporting gait parameters in the MS population has largely focused on preferred walking speed without the use of an assistive device. However, these data may not fully represent daily activity, as individuals with MS vary their speed or use a cane when walking. In this exploratory study, 11 MS participants and 13 controls walked at both maximal and preferred speed for a distance of 25-feet. Participants with MS that used a cane daily (n = 6) were asked to complete additional trials with their cane. When walking unassisted at both speeds, MS participants displayed significantly reduced velocity, cadence, stride length, step length ratio, single support and swing time, as well as increased double support and stance time compared to controls. Cane use resulted in significantly higher velocities when walking at maximal speeds, and showed significantly improved variability, gait asymmetry, and bilateral coordination at preferred walking speed. In conclusion, the use of a cane may significantly improve gait for individuals with MS. Furthermore, gait parameters should be measured at both maximal and preferred speeds, with and without a cane, as its use may mask underlying gait impairment. JF - Gait & Posture AU - Gianfrancesco, Milena A AU - Triche, Elizabeth W AU - Fawcett, Jennifer A AU - Labas, Michele P AU - Patterson, Tara S AU - Lo, Albert C AD - Providence VA Medical Center, VA RR&D Center for Restorative and Regenerative Medicine, Providence, RI, United States, Albert.Lo@va.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 140 EP - 142 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 33 IS - 1 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Measurement KW - Speed KW - Pace KW - Coordination KW - Multiple sclerosis KW - Walking KW - Velocity KW - Gait KW - Laterality KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954610246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=Speed-+and+cane-related+alterations+in+gait+parameters+in+individuals+with+multiple+sclerosis&rft.au=Gianfrancesco%2C+Milena+A%3BTriche%2C+Elizabeth+W%3BFawcett%2C+Jennifer+A%3BLabas%2C+Michele+P%3BPatterson%2C+Tara+S%3BLo%2C+Albert+C&rft.aulast=Gianfrancesco&rft.aufirst=Milena&rft.date=2011-01-01&rft.volume=33&rft.issue=1&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2010.09.016 LA - English DB - Physical Education Index N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Measurement; Coordination; Pace; Speed; Multiple sclerosis; Velocity; Walking; Laterality; Gait DO - http://dx.doi.org/10.1016/j.gaitpost.2010.09.016 ER - TY - JOUR T1 - Managing Chronic Heart Failure Patient in Chronic Kidney Disease AN - 954600847; 14253650 AB - Management of systolic heart failure can be particularly challenging in patients with chronic kidney disease, especially those who are not yet receiving dialysis. Few clinical trials have been performed in this particular population, so management is directed by evidence from studies of patients with limited or no renal impairment. Their heightened risk for many treatment complications mandates additional considerations regarding drug selection, dosing, and monitoring. Subspecialty consultation is driven by patient instability or disease progression, intolerance of standard treatment, or need for device placement. JF - American Journal of Medicine AU - Abdo, Ashraf S AU - Basu, Anita AU - Geraci, Stephen A AD - Medical Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Ashraf.Abdo@va.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 26 EP - 28 PB - Elsevier BV, PO Box 10670 Riverton, NJ 08076 USA VL - 124 IS - 1 SN - 0002-9343, 0002-9343 KW - Risk Abstracts KW - Dialysis KW - renal function KW - clinical trials KW - complications KW - Kidney KW - Drugs KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954600847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Medicine&rft.atitle=Managing+Chronic+Heart+Failure+Patient+in+Chronic+Kidney+Disease&rft.au=Abdo%2C+Ashraf+S%3BBasu%2C+Anita%3BGeraci%2C+Stephen+A&rft.aulast=Abdo&rft.aufirst=Ashraf&rft.date=2011-01-01&rft.volume=124&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Medicine&rft.issn=00029343&rft_id=info:doi/10.1016%2Fj.amjmed.2010.05.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Dialysis; complications; renal function; Kidney; clinical trials; Drugs DO - http://dx.doi.org/10.1016/j.amjmed.2010.05.030 ER - TY - JOUR T1 - Not just fun and games: applications of virtual reality in the identification and rehabilitation of cognitive disorders of the elderly AN - 925740805; 201203854 AB - Purpose. To outline the evidence in the published medical literature suggesting the potential applications of virtual reality (VR) for the identification and rehabilitation of cognitive disorders of the elderly. Method. Non-systematic literature review. Results. VR, despite its more common usage by younger persons, is a potentially promising source of techniques useful in the identification and rehabilitation of cognitive disorders of the elderly. Systems employing VR can include desktop and head-mounted visual displays among other devices. Thus far, published studies have described VR-based applications in the identification and treatment of deficits in navigational skills in ambulation and driving. In addition, VR has been utilised to enhance the ability to perform activities of daily living in patients with dementia, stroke, and Parkinson's Disease. Such investigations have thus far been small, and unblinded. Conclusions. VR-based applications can potentially offer more versatile, comprehensive, and safer assessments of function. However, they also might be more expensive, complex and more difficult to use by elderly patients. Side effects of head-mounted visual displays include nausea and disorientation, but, have not been reported specifically in older subjects. Adapted from the source document. JF - Disability and Rehabilitation: Assistive Technology AU - Cherniack, E Paul AD - Geriatrics Institute, Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Miami Miller School of Medicine, FL, USA and Geriatrics and Extended Care Service and Geriatric Research, Education, and Clinical Center, Bruce W. Carter Veterans Affairs Medical Center, Miami, FL, USA evan.cherniack@va.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 283 EP - 289 PB - Taylor & Francis, Abingdon UK VL - 6 IS - 4 SN - 1748-3107, 1748-3107 KW - Virtual, reality KW - Elderly people KW - Virtual reality KW - Rehabilitation KW - Cognitive disorders KW - Visual displays KW - Identification KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925740805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Disability+and+Rehabilitation%3A+Assistive+Technology&rft.atitle=Not+just+fun+and+games%3A+applications+of+virtual+reality+in+the+identification+and+rehabilitation+of+cognitive+disorders+of+the+elderly&rft.au=Cherniack%2C+E+Paul&rft.aulast=Cherniack&rft.aufirst=E&rft.date=2011-01-01&rft.volume=6&rft.issue=4&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Disability+and+Rehabilitation%3A+Assistive+Technology&rft.issn=17483107&rft_id=info:doi/10.3109%2F17483107.2010.542570 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Identification; Elderly people; Rehabilitation; Cognitive disorders; Virtual reality; Visual displays DO - http://dx.doi.org/10.3109/17483107.2010.542570 ER - TY - JOUR T1 - Traumatic Brain Injury AN - 919971793; 201203233 AB - Nurse practitioners have a major role to play in the detection and diagnosis of traumatic brain injury (TBI), which can be challenging if symptoms appear after the injury but go unrecognized. TBI should be considered when the patient reports a possible brain injury or experiences driving, sports, assault, falls, injuries, and combat. Recognizing the broad spectrum of symptoms will help NPs remain alert to the possibility of a TBI. Because symptoms are diverse and patients may not realize that the brain was injured, clinicians need a high index of suspicion. Early identification can improve treatment effectiveness, rehabilitation, and prognosis. [Copyright Elsevier B.V.] JF - The Journal for Nurse Practitioners AU - Valente, Sharon M AU - Fisher, Diane Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 863 EP - 870 PB - Elsevier Ltd, The Netherlands VL - 7 IS - 10 SN - 1555-4155, 1555-4155 KW - brain injury neurological KW - Symptoms KW - Rehabilitation KW - Injuries KW - Brain injuries KW - Assault KW - Traumatic brain injury KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919971793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+for+Nurse+Practitioners&rft.atitle=Traumatic+Brain+Injury&rft.au=Valente%2C+Sharon+M%3BFisher%2C+Diane&rft.aulast=Valente&rft.aufirst=Sharon&rft.date=2011-01-01&rft.volume=7&rft.issue=10&rft.spage=863&rft.isbn=&rft.btitle=&rft.title=The+Journal+for+Nurse+Practitioners&rft.issn=15554155&rft_id=info:doi/10.1016%2Fj.nurpra.2011.09.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Symptoms; Traumatic brain injury; Brain injuries; Injuries; Assault; Rehabilitation DO - http://dx.doi.org/10.1016/j.nurpra.2011.09.016 ER - TY - JOUR T1 - The Structure of PTSD Among Two Cohorts of Returning Soldiers: Before, During, and Following Deployment to Iraq AN - 919970604; 201202496 AB - Evidence suggests either a four-factor emotional numbing or dysphoria model likely reflects the underlying structure of posttraumatic stress disorder (PTSD). Questions remain as to which of these structures best represents PTSD, how the structure changes with time, the applicability of models to returning veterans, and the validity of the symptom clusters. The present study addresses these questions among two longitudinal samples of National Guard soldiers assessed prior to, during, and following a combat deployment to Iraq. Findings support a four-factor intercorrelated dysphoria model of PTSD that remains stable across samples and time points. Differential associations were observed among PTSD symptom clusters over time and between symptom clusters and both depression and combat exposure, supporting important distinctions between symptom clusters. [Copyright American Psychological Association] JF - Journal of Abnormal Psychology AU - Meis, Laura A AU - Erbes, Christopher R AU - Kaler, Matthew E AU - Arbisi, Paul A AU - Polusny, Melissa A AD - Center for Chronic Disease Outcomes Research, Minneapolis, Minnesota Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 807 EP - 818 PB - American Psychological Association, Washington DC VL - 120 IS - 4 SN - 0021-843X, 0021-843X KW - posttraumatic stress disorder latent factor structure longitudinal returning veterans KW - Symptoms KW - Depression KW - Posttraumatic stress disorder KW - Soldiers KW - Iraq KW - Deployment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919970604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Psychology&rft.atitle=The+Structure+of+PTSD+Among+Two+Cohorts+of+Returning+Soldiers%3A+Before%2C+During%2C+and+Following+Deployment+to+Iraq&rft.au=Meis%2C+Laura+A%3BErbes%2C+Christopher+R%3BKaler%2C+Matthew+E%3BArbisi%2C+Paul+A%3BPolusny%2C+Melissa+A&rft.aulast=Meis&rft.aufirst=Laura&rft.date=2011-01-01&rft.volume=120&rft.issue=4&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Psychology&rft.issn=0021843X&rft_id=info:doi/10.1037%2Fa0023976 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JABCAA N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Symptoms; Depression; Soldiers; Deployment; Iraq DO - http://dx.doi.org/10.1037/a0023976 ER - TY - JOUR T1 - Best Practices in the Veterans Health Administration's MOVE! Weight Management Program AN - 919969936; 201202118 AB - Obesity is a substantial problem in the Veterans Health Administration (VHA). VHA developed and disseminated the MOVE! Weight Management Program for Veterans to its medical facilities but implementation of the program has been variable. Purpose: The objective was to explore variation in MOVE! program implementation to identify facility structure, policies, and processes associated with larger patient weight-loss outcomes. Methods: Qualitative comparative analysis (QCA) was used to identify facility conditions or combinations of conditions associated with larger 6-month patient weight-loss outcomes. QCA is a method that allows for systematic cross-case comparison to better understand causal complexity. Eleven sites with larger outcomes and 11 sites with smaller outcomes were identified and data were collected with site interviews, facility-completed program summary forms, and medical record abstraction in 2009 and 2010. Conditions were selected based on theory and experience implementing MOVE! and were calibrated using QCA methods. Configuration patterns were examined to identify necessary conditions (i.e., always present when outcome present, but alone do not guarantee outcome) and sufficient conditions (i.e., presence guarantees outcome) at sites with larger and smaller outcomes. A thematic analysis of site interview data supplemented QCA findings. Results: No two sites shared the same condition pattern. Necessary conditions included the use of a standard curriculum and group care-delivery format, and they were present at all sites with larger outcomes but at only six sites with smaller outcomes. At the 17 sites with both necessary conditions, four combinations of conditions were identified that accounted for all sites with larger outcomes. These included high program complexity combined with high staff involvement; group care-delivery format combined with low accountability to facility leadership; an active physician champion combined with low accountability to facility leadership; and the use of quality-improvement strategies combined with not using a waiting list. Conclusions: The use of a standard curriculum delivered with a group care-delivery format is an essential feature of successful VHA facility MOVE! Weight Management Programs, but alone does not guarantee success. Program development and policy will be used to ensure dissemination of the best practices identified in this evaluation. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Kahwati, Leila C AU - Lewis, Megan A AU - Kane, Heather AU - Williams, Pamela A AU - Nerz, Patrick AU - Jones, Kenneth R AU - Lance, Trang X AU - Vaisey, Stephen AU - Kinsinger, Linda S AD - National Center for Health Promotion and Disease Prevention, Veterans Health Administration, Durham, North Carolina Leila.kahwati@va.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 457 EP - 464 PB - Elsevier Science, New York NY VL - 41 IS - 5 SN - 0749-3797, 0749-3797 KW - Veterans KW - Best practice KW - Curriculum KW - Weight loss KW - Accountability KW - Leadership KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919969936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Best+Practices+in+the+Veterans+Health+Administration%27s+MOVE%21+Weight+Management+Program&rft.au=Kahwati%2C+Leila+C%3BLewis%2C+Megan+A%3BKane%2C+Heather%3BWilliams%2C+Pamela+A%3BNerz%2C+Patrick%3BJones%2C+Kenneth+R%3BLance%2C+Trang+X%3BVaisey%2C+Stephen%3BKinsinger%2C+Linda+S&rft.aulast=Kahwati&rft.aufirst=Leila&rft.date=2011-01-01&rft.volume=41&rft.issue=5&rft.spage=457&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2011.06.047 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Weight loss; Leadership; Veterans; Best practice; Curriculum; Accountability DO - http://dx.doi.org/10.1016/j.amepre.2011.06.047 ER - TY - JOUR T1 - A Revised Measure of Occupational Stress for Firefighters: Psychometric Properties and Relationship to Posttraumatic Stress Disorder, Depression, and Substance Abuse AN - 919969752; 201202173 AB - The Sources of Occupational Stress scale (SOOS; Beaton & Murphy, 1993) is a 57-item self-report measure designed to assess the different sources of occupational stress faced by firefighters. The objective of the present research was to develop and evaluate an abbreviated version of the SOOS in order to reduce respondent burden. The revised 14-item version of the SOOS was evaluated in 2 independent samples of firefighters (N = 408) along with measures of job outcomes, posttraumatic stress disorder, depression, and substance abuse. The SOOS-14 exhibited good internal consistency, good factor structure, and good validity coefficients across samples. Although additional studies are needed to replicate and expand on these results, the findings from the present research indicate that the SOOS-14 is a practical, reliable, and valid measure of occupational stress for firefighters. [Copyright Elsevier B.V.] JF - Psychological Services AU - Kimbrel, Nathan A AU - Steffen, Laurie E AU - Meyer, Eric C AU - Kruse, Marc I AU - Knight, Jeffrey A AU - Zimering, Rose T AU - Gulliver, Suzy B AD - Department of Psychiatry and Behavioral Science, Texas A&M Health Science Center nathan.kimbrel@va.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 294 EP - 306 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 8 IS - 4 SN - 1541-1559, 1541-1559 KW - Depression KW - Posttraumatic stress disorder KW - Firefighters KW - Occupational stress KW - Selfreport KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919969752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=A+Revised+Measure+of+Occupational+Stress+for+Firefighters%3A+Psychometric+Properties+and+Relationship+to+Posttraumatic+Stress+Disorder%2C+Depression%2C+and+Substance+Abuse&rft.au=Kimbrel%2C+Nathan+A%3BSteffen%2C+Laurie+E%3BMeyer%2C+Eric+C%3BKruse%2C+Marc+I%3BKnight%2C+Jeffrey+A%3BZimering%2C+Rose+T%3BGulliver%2C+Suzy+B&rft.aulast=Kimbrel&rft.aufirst=Nathan&rft.date=2011-01-01&rft.volume=8&rft.issue=4&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0025845 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Firefighters; Occupational stress; Substance abuse; Posttraumatic stress disorder; Depression; Selfreport DO - http://dx.doi.org/10.1037/a0025845 ER - TY - JOUR T1 - Implementation and Evaluation of an Integrated Care Program in a VA Medical Center AN - 919969017; 201201127 AB - The integration of mental health services within primary care settings has received major attention recently. This project describes the development and implementation of an integration program at a Veterans Affairs medical center. An additional goal was to conduct a practical program evaluation demonstrating the ability of the program to be implemented within an already existing primary care clinic while still meeting important goals of integration. Despite challenges, the present project demonstrates that this is a feasible goal. [Copyright Elsevier B.V.] JF - Psychological Services AU - Barber, Jessica A AU - Franstve, Lisa M AU - Capelli, Sandra AU - Sanders, Kathryn A AD - VA Connecticut Health Care System jessica.barber@va.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 282 EP - 293 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 8 IS - 4 SN - 1541-1559, 1541-1559 KW - Veterans KW - Goals KW - Mental health services KW - Integrated services KW - Primary health care KW - Clinics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919969017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Implementation+and+Evaluation+of+an+Integrated+Care+Program+in+a+VA+Medical+Center&rft.au=Barber%2C+Jessica+A%3BFranstve%2C+Lisa+M%3BCapelli%2C+Sandra%3BSanders%2C+Kathryn+A&rft.aulast=Barber&rft.aufirst=Jessica&rft.date=2011-01-01&rft.volume=8&rft.issue=4&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0026158 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Goals; Integrated services; Primary health care; Mental health services; Clinics; Veterans DO - http://dx.doi.org/10.1037/a0026158 ER - TY - JOUR T1 - Dog walking: Its association with physical activity guideline adherence and its correlates AN - 911148554; 14258709 AB - Objective: We examined the prevalence and correlates of dog walking among dog owners, and whether dog walking is associated with meeting the American College of Sports Medicine/American Heart Association physical activity guidelines. Methods: In March 2008, we mailed a survey to dog-owning clients from two San Diego County veterinary clinics. Useable data were obtained from 984 respondents, and 75 of these completed retest surveys. We assessed associations between potential correlates and dog walking (i.e., yes/no dog walking for at least 10 min in past week). Results: Test-retest reliability of measures was generally high. Approximately one-third of the sample (31.5%) were not dog walkers. Proportions of dog walkers versus non-dog walkers meeting United States guidelines were 64.3% and 55.0%, respectively. Dog walking was independently associated with meeting guidelines in a multivariate model (odds ratio = 1.59, p = 0.004). Three variables were independently associated with dog walking in a multivariate model: dog encouragement of dog walking, dog-walking obligation, and dog-walking self-efficacy. Conclusion: Dog walking was associated with meeting physical activity guidelines, making it a viable method for promoting physical activity. Dog-walking obligation and self-efficacy may be important mediators of dog walking and may need to be targeted if interventions are to be successful. JF - Preventive Medicine AU - Hoerster, Katherine D AU - Mayer, Joni A AU - Sallis, James F AU - Pizzi, Nicole AU - Talley, Sandra AU - Pichon, Latrice C AU - Butler, Dalila A AD - San Diego State University Graduate School of Public Health, 9245 Sky Park Court, Suite 220, San Diego, CA 92123, USA, Katherine.Hoerster@va.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 33 EP - 38 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 52 IS - 1 SN - 0091-7435, 0091-7435 KW - Physical Education Index KW - ACSM KW - American Heart Association KW - Reliability KW - Objectives KW - Compliance KW - Walking KW - Surveys KW - Exercise KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911148554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=Dog+walking%3A+Its+association+with+physical+activity+guideline+adherence+and+its+correlates&rft.au=Hoerster%2C+Katherine+D%3BMayer%2C+Joni+A%3BSallis%2C+James+F%3BPizzi%2C+Nicole%3BTalley%2C+Sandra%3BPichon%2C+Latrice+C%3BButler%2C+Dalila+A&rft.aulast=Hoerster&rft.aufirst=Katherine&rft.date=2011-01-01&rft.volume=52&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2010.10.011 LA - English DB - Physical Education Index N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - ACSM; Objectives; Reliability; American Heart Association; Compliance; Surveys; Walking; Exercise DO - http://dx.doi.org/10.1016/j.ypmed.2010.10.011 ER - TY - JOUR T1 - Alcoholism and identity: How an alternative framing of identity can facilitate Alcoholics Anonymous research AN - 908021663; 201122632 AB - Motivational interviewing (MI), cognitive-behavioral therapy (CBT), and Alcoholics Anonymous (AA) are the most common therapeutic approaches for alcoholism recovery. Whereas the former two are clinical treatments grounded in scientific theory, AA emerged as a peer-led program grounded in an array of scientific, social, and spiritual concepts. Researchers have failed to comprehensively identify AA's therapeutic mechanisms or to definitively link them to recovery outcomes. This failure may result from the false assumption that AA frames identity in the same way evidence-based psychological treatments do. This article explores the significance of identity to recovery from alcoholism. MI presumes a personal identity and CBT presumes a social identity. Measures of personal and social attributes are appropriate to these interventions. AA, however, promotes a relational identity which cannot be fully captured using measures of individual attributes. The implications for this shortcoming are presented, along with several suggestions to enhance future research. Adapted from the source document. JF - Addiction Research & Theory AU - Young, Lance Brendan Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 213 EP - 223 PB - Routledge/Taylor & Francis, Abingdon UK VL - 19 IS - 2 SN - 1606-6359, 1606-6359 KW - Alcoholism, addiction, self-help, recovery, identity, alcoholics anonymous KW - Evidence based KW - Cognitive behaviour therapy KW - Recovery KW - Identity KW - Alcoholism KW - Alcoholics Anonymous KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/908021663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+Research+%26+Theory&rft.atitle=Alcoholism+and+identity%3A+How+an+alternative+framing+of+identity+can+facilitate+Alcoholics+Anonymous+research&rft.au=Young%2C+Lance+Brendan&rft.aulast=Young&rft.aufirst=Lance&rft.date=2011-01-01&rft.volume=19&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Addiction+Research+%26+Theory&rft.issn=16066359&rft_id=info:doi/10.3109%2F16066359.2010.530712 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AREREQ N1 - SubjectsTermNotLitGenreText - Identity; Cognitive behaviour therapy; Alcoholism; Recovery; Alcoholics Anonymous; Evidence based DO - http://dx.doi.org/10.3109/16066359.2010.530712 ER - TY - JOUR T1 - An Evolving Integrative Treatment Program for Military Sexual Trauma (MST) and One Veteran's Experience AN - 902097433; 201119366 AB - Military sexual trauma (MST) increases the risk for Posttraumatic Stress Disorder (PTSD) and multiple other comorbidities, presenting substantial challenges for nurses and psychiatric and medical clinicians. A specialized VA Medical Center outpatient program is patterned after Herman's three-phased, empirically-supported, recovery treatments. We use a case example of a female veteran MST survivor to illustrate our treatment model. She presented to our program meeting diagnostic criteria for PTSD, Major Depressive Disorder, and a history of substance abuse. Post-treatment she demonstrated improved scores on measures of PTSD, quality of life, and socialization. This model shows promise for treatment of MST survivors with PTSD. Adapted from the source document. JF - Issues in Mental Health Nursing AU - Ferdinand, Lisa G AU - Kelly, Ursula A AU - Skelton, Kelly AU - Stephens, Kisha J AU - Bradley, Bekh AD - Atlanta VA Medical Center, Trauma Recovery Program, Decatur, Georgia, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 552 EP - 559 PB - Informa Healthcare, Taylor & Francis, New York NY VL - 32 IS - 9 SN - 0161-2840, 0161-2840 KW - Posttraumatic stress disorder KW - Treatment methods KW - Survivors KW - Comorbidity KW - Substance abuse KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902097433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Issues+in+Mental+Health+Nursing&rft.atitle=An+Evolving+Integrative+Treatment+Program+for+Military+Sexual+Trauma+%28MST%29+and+One+Veteran%27s+Experience&rft.au=Ferdinand%2C+Lisa+G%3BKelly%2C+Ursula+A%3BSkelton%2C+Kelly%3BStephens%2C+Kisha+J%3BBradley%2C+Bekh&rft.aulast=Ferdinand&rft.aufirst=Lisa&rft.date=2011-01-01&rft.volume=32&rft.issue=9&rft.spage=552&rft.isbn=&rft.btitle=&rft.title=Issues+in+Mental+Health+Nursing&rft.issn=01612840&rft_id=info:doi/10.3109%2F01612840.2011.582228 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - CODEN - IHNUDT N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Survivors; Quality of life; Substance abuse; Treatment methods; Comorbidity DO - http://dx.doi.org/10.3109/01612840.2011.582228 ER - TY - JOUR T1 - Doctoral Persistence and Doctoral Program Completion Among Nurses AN - 896166210; 201116483 AB - PROBLEM. The United States is experiencing a critical shortage of registered nurses, which is due to multiple factors, including a deficit of full-time doctorally prepared nursing faculty. METHODS AND FINDINGS. This review of the literature addresses doctoral persistence and the challenges faced by doctoral nursing students. Themes found in this review included periods of transition, parenthood and outside demands, delays and "marinating" in the data, and positive aspects. These issues need to be addressed in order to increase doctoral student retention and reverse the nursing shortage. Adapted from the source document. JF - Nursing Forum AU - Cohen, Shannon Munro AD - Health Promotion Disease Prevention Program Director, Veterans Administration, Salem, VA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 64 EP - 70 PB - Wiley-Blackwell, UK VL - 46 IS - 2 SN - 0029-6473, 0029-6473 KW - Shortages KW - Nursing KW - Nurses KW - Professors KW - Retention KW - Doctoral postgraduate education KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896166210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Forum&rft.atitle=Doctoral+Persistence+and+Doctoral+Program+Completion+Among+Nurses&rft.au=Cohen%2C+Shannon+Munro&rft.aulast=Cohen&rft.aufirst=Shannon&rft.date=2011-01-01&rft.volume=46&rft.issue=2&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Nursing+Forum&rft.issn=00296473&rft_id=info:doi/10.1111%2Fj.1744-6198.2011.00212.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Doctoral postgraduate education; Nursing; Shortages; Nurses; Professors; Retention DO - http://dx.doi.org/10.1111/j.1744-6198.2011.00212.x ER - TY - JOUR T1 - Activities of tigecycline and comparators against Legionella pneumophila and Legionella micdadei extracellularly and in human monocyte-derived macrophages AN - 888092812; 14199489 AB - The activity of tigecycline against Legionellae, which are intracellular pathogens, was evaluated intracellularly in human phagocytes and extracellularly, and compared to the activities of erythromycin and levofloxacin. Clinical isolates of L. pneumophila serogroups 1, 5, and 6 and L. micdadei were tested in time-kill experiments. Extracellular experiments were done using buffered yeast extract broth. For intracellular assays, monolayers of human monocyte-derived macrophages (MDM) were infected with L. pneumophila or L. micdadei. Antibiotics (0.05-2.5 A- MIC) were then added. MDM were lysed at 0, 24, 48, and 72 h and viable bacteria in the lysates were enumerated. Based on multiples of the MICs, tigecycline was less active extracellularly than levofloxacin or erythromycin. However, intracellular killing of both L. pneumophila and L. micdadei by tigecycline at 72 h was greater than for erythromycin or levofloxacin. Currently, evidence does not support the use of tigecycline as a first-line drug for treatment of Legionella infections. However, since Legionellae are intracellular pathogens, these results suggest that tigecycline should be effective for treatment of infections caused by these bacteria. JF - Diagnostic Microbiology and Infectious Disease AU - Bopp, Lawrence H AU - Baltch, Aldona L AU - Ritz, William J AU - Michelsen, Phyllis B AU - Smith, Raymond P AD - Stratton VA Medical Center, Albany, NY, USA, aldona.baltch@med.va.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 86 EP - 93 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 69 IS - 1 SN - 0732-8893, 0732-8893 KW - Microbiology Abstracts B: Bacteriology KW - Legionella KW - Tigecycline KW - Human monocytes KW - Clinical isolates KW - Macrophages KW - Legionella pneumophila KW - tigecycline KW - Levofloxacin KW - Antibiotics KW - Pathogens KW - Infection KW - Erythromycin KW - Intracellular killing KW - Minimum inhibitory concentration KW - Legionella micdadei KW - Phagocytes KW - Monocytes KW - Drugs KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888092812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+Microbiology+and+Infectious+Disease&rft.atitle=Activities+of+tigecycline+and+comparators+against+Legionella+pneumophila+and+Legionella+micdadei+extracellularly+and+in+human+monocyte-derived+macrophages&rft.au=Bopp%2C+Lawrence+H%3BBaltch%2C+Aldona+L%3BRitz%2C+William+J%3BMichelsen%2C+Phyllis+B%3BSmith%2C+Raymond+P&rft.aulast=Bopp&rft.aufirst=Lawrence&rft.date=2011-01-01&rft.volume=69&rft.issue=1&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Diagnostic+Microbiology+and+Infectious+Disease&rft.issn=07328893&rft_id=info:doi/10.1016%2Fj.diagmicrobio.2010.08.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Macrophages; Clinical isolates; tigecycline; Levofloxacin; Antibiotics; Pathogens; Erythromycin; Infection; Minimum inhibitory concentration; Intracellular killing; Phagocytes; Monocytes; Drugs; Legionella pneumophila; Legionella micdadei DO - http://dx.doi.org/10.1016/j.diagmicrobio.2010.08.023 ER - TY - JOUR T1 - Typical And Atypical Dementia Family Caregivers: Systematic And Objective Comparisons AN - 871000287; 201102678 AB - This systematic, objective comparison of typical (spouse, children) and atypical (in-law, sibling, nephew/niece, grandchild) dementia family caregivers examined demographic, caregiving and clinical variables. Analysis was of 1,476 caregivers, of whom 125 were atypical, from the Resources for Enhancing Alzheimer's Caregivers Health (REACH I and II) studies. Based on statistical and clinical significance, there were large effects for demographics but no large effects among caregivers or care recipients on clinical and caregiving variables. Non-spouse family members were more likely to be caring for women and unmarried individuals. Grandchildren and nieces/nephews provided care for older care recipients. For care recipients who are unmarried, older, or women, fewer care possibilities may be available; consequently family members other than spouse or children may become their caregivers. Once an individual becomes a caregiver, the clinical experience of dementia caregiving is similar across caregiver types. These findings have implications for clinical care and public policy. Adapted from the source document. JF - International Journal of Aging and Human Development AU - Nichols, Linda O AU - Martindale-Adams, Jennifer AU - Burns, Robert AU - Graney, Marshall J AU - Zuber, Jeffrey AD - VA Medical Center at Memphis (11H), 1030 Jefferson Avenue, Memphis, TN 38104 E-mail: linda.nichols@va.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 27 EP - 43 PB - Baywood Publishing, Amityville NY VL - 72 IS - 1 SN - 0091-4150, 0091-4150 KW - Caregivers KW - Family Relations KW - Senility KW - Elderly KW - Family KW - Siblings KW - Females KW - Children KW - Sociodemographic Factors KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/871000287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Aging+and+Human+Development&rft.atitle=Typical+And+Atypical+Dementia+Family+Caregivers%3A+Systematic+And+Objective+Comparisons&rft.au=Nichols%2C+Linda+O%3BMartindale-Adams%2C+Jennifer%3BBurns%2C+Robert%3BGraney%2C+Marshall+J%3BZuber%2C+Jeffrey&rft.aulast=Nichols&rft.aufirst=Linda&rft.date=2011-01-01&rft.volume=72&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Aging+and+Human+Development&rft.issn=00914150&rft_id=info:doi/10.2190%2FAG.72.1.D LA - English DB - Social Services Abstracts N1 - Date revised - 2011-06-07 N1 - Last updated - 2016-09-28 N1 - CODEN - IJADDT N1 - SubjectsTermNotLitGenreText - Caregivers; Family; Senility; Sociodemographic Factors; Females; Children; Siblings; Elderly; Family Relations DO - http://dx.doi.org/10.2190/AG.72.1.D ER - TY - JOUR T1 - Some observations on the nature of the audiometric 4000 hz notch: data from 3430 veterans. AN - 863416673; pmid-21419067 AB - Pure-tone, air-conduction audiograms notched at 4000 Hz have long been considered the signature configuration for noise-induced hearing loss even though there is an extensive literature that does not mesh with this simple explanation. There are many reports of notched audiograms from individuals with no history of noise exposure and, conversely, reports of audiograms with no notches from individuals with a history of noise exposure. Recent reports increasingly suggest that unilateral 4000 Hz notches are common. The prevalence of notched audiograms at 4000 Hz is dependent on the definition of the notch and the population under study.To examine the prevalence and characteristics of audiograms that are notched at 4000 Hz.Retrospective, descriptive.The participants were 3430 veterans evaluated in the Audiology Clinic at the VA Medical Center, Mountain Home, Tennessee. The mean age was 62.3 yr. Data Collection and Analyses: The data were collected in the course of a 60 min, routine audiological evaluation. In addition to pure-tone audiometry, a history, otoscopy, speech audiometry in quiet and in noise, and aural-acoustic immittance measures were included in the clinic protocol but were not evaluated in this report. A notch was defined when the 4000 Hz threshold minus the 2000 Hz threshold and the 4000 Hz threshold minus the 8000 Hz threshold both were ≥10 dB.Overall the mean LE (left ear) thresholds at 2000, 3000, and 4000 Hz were at hearing levels 2-3 dB higher than the hearing levels for the corresponding mean RE (right ear) thresholds; the differences were significant. A notched audiogram was observed in 40.6% of the participants in at least one ear with 15.4% having bilateral notches, 28.8% LE notches, and 27.1% RE notches. Unilateral 4000 Hz notches were almost twice as prevalent as bilateral 4000 Hz notches. Viewed as a function of age, notched audiograms were most common (∼35% of the participants) in the 40 and 50 yr groups with a diminishing prevalence in the 60-80 yr groups. The mean notch depth at 4000 Hz was consistently 20-26 dB across the seven age groups. In comparison to the thresholds of the audiograms that were not notched, the thresholds of the audiograms with 4000 Hz notches (1) at 250-2000 Hz were at hearing levels 2-3 dB lower, (2) at 3000 and 4000 Hz were at hearing levels 8-17 dB higher, and (3) at 8000 Hz were at hearing levels 3-4 dB lower; the threshold differences were significant at all frequencies for both ears.The data suggest that unilateral, 4000 Hz notched audiograms are as common or more common than bilateral notched audiograms and that unilateral notched audiograms are equally common for the LE and RE. The prevalence and characteristics of 4000 Hz notched audiograms in this veteran sample are similar to those observed in the population as a whole.American Academy of Audiology. JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AD - James H. Quillen VA Medical Center, Mountain Home, TN 37684, USA. richard.wilson2@va.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 23 EP - 33 VL - 22 IS - 1 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - *Audiometry, Pure-Tone KW - Auditory Threshold KW - *Hearing Loss, Noise-Induced: diagnosis KW - Humans KW - Male KW - Middle Aged KW - Young Adult UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863416673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Some+observations+on+the+nature+of+the+audiometric+4000%C2%A0hz+notch%3A+data+from+3430+veterans.&rft.au=Wilson%2C+Richard+H&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2011-01-01&rft.volume=22&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: J Am Acad Audiol. 2011 Jan;22(1):4[21419064] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Psychiatric diagnoses, comorbidity, and functioning in National Guard troops deployed to Iraq AN - 862591155; 201109922 AB - Objective Over 1.8 million troops have been deployed to Iraq (OIF) and Afghanistan. Estimates of mental health problems postdeployment have been based on screening instruments; no studies have examined the postdeployment mental health of troops returning from OIF using structured diagnostic interviews. The goal of the current study is to (a) report on rates of mental health diagnoses and comorbidity in soldiers after deployment to OIF using clinical interviews, and (b) examine the relationship between mental health diagnoses and overall functioning and quality of life. Method Participants were 348 National Guard soldiers drawn from the Readiness and Resilience in National Guard Soldiers (RINGS) study, a longitudinal study of mental health after deployment to OIF from March 2006 to July 2007. Participants completed clinical interviews, including the Clinician Administered PTSD Scale and the Structured Clinical Interview for the DSM-IV, and self-report measures of social adjustment and quality of life 6-12 months following deployment. Results Most participants did not meet criteria for a mental health diagnosis. Non-PTSD anxiety disorders and depressive disorders were the most common. Mental health diagnoses were associated with poorer functioning and quality of life. PTSD had the strongest relationship with social functioning and quality of life. For those with PTSD, comorbid diagnoses were not associated with an incremental decrease in functioning or quality of life. Conclusions The findings highlight the significant rate and burden of mental health disorders among this population and suggest that while PTSD is relatively uncommon, it is a particularly deleterious disorder. [Copyright Elsevier Ltd.] JF - Journal of Psychiatric Research AU - Kehle, Shannon M AU - Reddy, Madhavi K AU - Ferrier-Auerbach, Amanda G AU - Erbes, Christopher R AU - Arbisi, Paul A AU - Polusny, Melissa A AD - Center for Chronic Disease Outcomes Research, Minneapolis, MN, USA Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 126 EP - 132 PB - Elsevier Ltd, Oxford UK VL - 45 IS - 1 SN - 0022-3956, 0022-3956 KW - Posttraumatic stress disorder (PTSD) Trauma Military Psychiatric diagnosis Quality of life KW - Posttraumatic stress disorder KW - Soldiers KW - Mental health KW - Comorbidity KW - Deployment KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862591155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychiatric+Research&rft.atitle=Psychiatric+diagnoses%2C+comorbidity%2C+and+functioning+in+National+Guard+troops+deployed+to+Iraq&rft.au=Kehle%2C+Shannon+M%3BReddy%2C+Madhavi+K%3BFerrier-Auerbach%2C+Amanda+G%3BErbes%2C+Christopher+R%3BArbisi%2C+Paul+A%3BPolusny%2C+Melissa+A&rft.aulast=Kehle&rft.aufirst=Shannon&rft.date=2011-01-01&rft.volume=45&rft.issue=1&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychiatric+Research&rft.issn=00223956&rft_id=info:doi/10.1016%2Fj.jpsychires.2010.05.013 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - CODEN - JPYRA3 N1 - SubjectsTermNotLitGenreText - Mental health; Quality of life; Posttraumatic stress disorder; Soldiers; Deployment; Comorbidity DO - http://dx.doi.org/10.1016/j.jpsychires.2010.05.013 ER - TY - JOUR T1 - Incremental Cost-Effectiveness of Various Monthly Doses of Vardenafil AN - 862591135; 201108711 AB - Objective: To compare the cost-effectiveness of four, six, & eight doses per month of vardenafil in the context of pharmacy benefit decision making. Methods: A Markov model was used to estimate the incremental cost-effectiveness of zero, four, six, or eight doses of vardenafil per month in hypothetical cohorts of 60-year-old male veterans with erectile dysfunction. Efficacy values for vardenafil were obtained from the literature, & vardenafil costs were obtained from Veterans Affairs pharmacy data. The analysis was conducted from a third-party payer perspective with a lifetime horizon, & the effect of parameter uncertainty was explored in one-way & probabilistic sensitivity analyses. Results: In the base case analysis, the cost per quality-adjusted life-year gained for four doses of vardenafil per month compared with no therapy was $576. Six doses per month compared with four cost $2585/quality-adjusted life-year gained, & eight doses per month compared with six cost $5169/quality-adjusted life-year gained. In one-way sensitivity analyses of six doses per month compared with four, variation of two parameters caused the incremental cost-effectiveness ratio to cross a willingness-to-pay threshold of $20,000: when the increased utility associated with giving two additional doses/month was less than 0.001 (baseline 0.01) & when the cost per dose increased to $15.00 (baseline $1.69). Conclusion: Although four doses per month of vardenafil was the most cost-effective strategy, the use of six or eight doses per month also compares favorably with other accepted medical treatments. The results were stable across a range of inputs & help to support the current Veterans Affairs policy on the number of vardenafil doses provided per month for erectile dysfunction. Adapted from the source document. JF - Value in Health AU - Aspinall, Sherrie L AU - Smith, Kenneth J AU - Cunningham, Francesca E AU - Good, Chester B AD - VA Center for Health Equity Research & Promotion, VA Pittsburgh Healthcare System, PA sherrie.aspinall@va.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 97 EP - 101 PB - Wiley Publishing, Malden, MA 02148 VL - 14 IS - 1 SN - 1098-3015, 1098-3015 KW - Cost-effectiveness KW - Cost-utility KW - Vardenafil KW - Erectile dysfunction KW - Veterans KW - Parameters KW - Sensitivity analysis KW - Dosage KW - Cost effectiveness KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862591135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Value+in+Health&rft.atitle=Incremental+Cost-Effectiveness+of+Various+Monthly+Doses+of+Vardenafil&rft.au=Aspinall%2C+Sherrie+L%3BSmith%2C+Kenneth+J%3BCunningham%2C+Francesca+E%3BGood%2C+Chester+B&rft.aulast=Aspinall&rft.aufirst=Sherrie&rft.date=2011-01-01&rft.volume=14&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Value+in+Health&rft.issn=10983015&rft_id=info:doi/10.1016%2Fj.jval.2010.10.021 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Dosage; Cost effectiveness; Veterans; Sensitivity analysis; Erectile dysfunction; Parameters DO - http://dx.doi.org/10.1016/j.jval.2010.10.021 ER - TY - JOUR T1 - Validity of PTSD diagnoses in VA administrative data: Comparison of VA administrative PTSD diagnoses to self-reported PTSD Checklist scores AN - 856784017; 14392011 AB - Little research has been done on the validity of post-traumatic stress disorder (PTSD) diagnoses that are found in Department of Veterans Affairs (VA) administrative data, even though they are often used in VA research. We compared PTSD diagnoses found in VA administrative data with PTSD Checklist (PCL) scores self-reported by 4,777 newly diagnosed participants in a national postal survey study. Using PCL scores of at least 50 as the gold standard, we compared positive predictive values (PPVs) for at least one versus at least two PTSD diagnoses (found within 4 months of the first) in VA administrative data overall and by subgroups of interest: age, sex, and clinic where first diagnosed. The overall PPV was 75% for at least one PTSD diagnosis and 82% for at least two PTSD diagnoses. Similarly, the PPV significantly increased for all subgroup analyses when at least two PTSD diagnoses were used. The increase in PPV was greatest for those first diagnosed in primary care and for those older than 65. To select a sample of veterans with more definitive PTSD from administrative data, researchers should select those veterans with at least two PTSD diagnoses as opposed to at least one. JF - Journal of Rehabilitation Research and Development AU - Gravely, A A AU - Cutting, A AU - Nugent, S AU - Grill, J AU - Carlson, K AU - Spoont, M AD - Minneapolis VAMC, Center for Chronic Disease Outcomes Research, 1 Veterans Drive, Minneapolis, MN 55417, USA, amy.gravely@va.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 21 EP - 30 VL - 48 IS - 1 SN - 0748-7711, 0748-7711 KW - Health & Safety Science Abstracts KW - Age KW - posttraumatic stress disorder KW - Research programs KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856784017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Validity+of+PTSD+diagnoses+in+VA+administrative+data%3A+Comparison+of+VA+administrative+PTSD+diagnoses+to+self-reported+PTSD+Checklist+scores&rft.au=Gravely%2C+A+A%3BCutting%2C+A%3BNugent%2C+S%3BGrill%2C+J%3BCarlson%2C+K%3BSpoont%2C+M&rft.aulast=Gravely&rft.aufirst=A&rft.date=2011-01-01&rft.volume=48&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2009.08.0116 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Age; posttraumatic stress disorder; Research programs DO - http://dx.doi.org/10.1682/JRRD.2009.08.0116 ER - TY - JOUR T1 - Battered Women's Perceptions of Civil and Criminal Court Helpfulness: The Role of Court Outcome and Process AN - 856405761; 201101688 AB - Although most battered women seeking formal help have some contact with court, limited research exists on what they find helpful and harmful about these experiences. Using qualitative data from low-income, largely Black battered women, this study finds that issues related to court outcomes, such as case disposition and enforcement, are important to evaluations of helpfulness. More frequently mentioned, however, are court processes, including treatment by staff, process length, and public disclosure. Results highlight the importance of research and practice attending to issues beyond court outcomes, as well as the potential impact supportive treatment at court may have for victims' recovery. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Violence Against Women AU - Bell, Margret E AU - Perez, Sara AU - Goodman, Lisa A AU - Dutton, Mary Ann AD - Department of Veterans Affairs Office of Mental Health Services, National Center for PTSD Margaret.bell@va.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 71 EP - 88 PB - Sage Publications, Thousand Oaks CA VL - 17 IS - 1 SN - 1077-8012, 1077-8012 KW - court intimate partner violence legal processes KW - Low Income Groups KW - Self Disclosure KW - Courts KW - Victims KW - Disposition KW - Battered Women KW - article KW - 6146: crime & corrections UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856405761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Violence+Against+Women&rft.atitle=Battered+Women%27s+Perceptions+of+Civil+and+Criminal+Court+Helpfulness%3A+The+Role+of+Court+Outcome+and+Process&rft.au=Bell%2C+Margret+E%3BPerez%2C+Sara%3BGoodman%2C+Lisa+A%3BDutton%2C+Mary+Ann&rft.aulast=Bell&rft.aufirst=Margret&rft.date=2011-01-01&rft.volume=17&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Violence+Against+Women&rft.issn=10778012&rft_id=info:doi/10.1177%2F1077801210393924 LA - English DB - Social Services Abstracts N1 - Date revised - 2011-03-07 N1 - Number of references - 57 N1 - Last updated - 2016-09-28 N1 - CODEN - VAWOFG N1 - SubjectsTermNotLitGenreText - Courts; Battered Women; Self Disclosure; Victims; Disposition; Low Income Groups DO - http://dx.doi.org/10.1177/1077801210393924 ER - TY - JOUR T1 - The Kovacs Guide to Electronic Library Collection Development: Essential Core Subject Collections, Selection Criteria, and Guidelines. 2nd ed AN - 855901116; 201101626 AB - Book review abstract. The Kovacs Guide to Electronic Library Collection Development: Essential Core Subject Collections, Selection Criteria, and Guidelines. 2nd ed by Diane K Kovacs. New York, NY: Neal-Schuman Publishers. 2009. 300 p. $150.00 ISBN: 978-1-55570-664-7. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Burns, Elizabeth C AU - Burns, Elizabeth C AD - Email: liz.burns@va.gov Medical Library, VA Medical Center, Kansas City, MO Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 102 PB - Medical Library Association, Chicago, IL VL - 99 IS - 1 SN - 1536-5050, 1536-5050 KW - Collection development KW - Electronic media KW - article KW - 1.11: BOOK REVIEWS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855901116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=The+Kovacs+Guide+to+Electronic+Library+Collection+Development%3A+Essential+Core+Subject+Collections%2C+Selection+Criteria%2C+and+Guidelines.+2nd+ed&rft.au=Burns%2C+Elizabeth+C&rft.aulast=Burns&rft.aufirst=Elizabeth&rft.date=2011-01-01&rft.volume=99&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/ L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Collection development; Electronic media ER - TY - JOUR T1 - Using game format to teach psychopharmacology to medical students AN - 855899919; 201108239 AB - Background: Most psychiatric programs provide lectures on basic principles of psychopharmacology. Yet, this traditional approach has been criticized due to excessive information and passive transfer of expert knowledge. An alternative teaching method is the use of "academic games." Aims: To investigate medical students' acquisition of knowledge on psychopharmacology, and their perception of a game playing approach compared to traditional lectures. Methods: Two senior residents designed, implemented, and executed a randomized pretest-posttest study to teach psychopharmacology, using an academic game and a lecture format, to third-year medical students during a 6-week Psychiatry clerkship. Both didactic interventions were delivered concurrently for five consecutive weeks covering five psychopharmacology modules: antidepressants I (selective serotonin reuptake inhibitors and atypical antidepressants), antidepressants II (monoamine oxidase inhibitors and tricyclic antidepressants), mood stabilizers, antipsychotics, and anti-anxiety agents/sedatives/hypnotics. The game follows similar rules of the famous TV show, "Jeopardy" using a power point grid and a multiple choice question format. Results: Forty-three medical students participated (29 assigned to the game approach, 14 to the traditional lecture approach). None of the demographic variables (age, gender, years after graduation, Graduate Point Averages, and United States Medical Licensing Examination 1) were significantly associated with the pre/posttest score difference between groups. Both groups improved their knowledge on psychotropic drugs [(game group t = 10.86, p < 0.001); control t = 4.82, p < 0.001)] throughout the 6-week Psychiatry rotation. Students in the game group had a better perception of this educational method as measured by perceived enjoyment, increased knowledge of psychopharmacology, and stimulating interest in the subject compared to those in the lecture group (p < 0.05). Conclusions: Teaching psychopharmacology in medical students by using academic games can make the learning experience more enjoyable and motivating; however, future studies with higher quality methodology and design are needed to determine the role of educational games in acquiring new psychopharmacological knowledge. Adapted from the source document. JF - Medical Teacher AU - Shiroma, Paulo R AU - Massa, Alfredo A AU - Alarcon, Renato D AD - Geriatric Psychiatry Clinic, Mental Health Service Line, Minneapolis VA Medical Center, University of Minnesota Medical School, One Veterans Drive, Minneapolis, MN 55417, USA paulo.shiroma@va.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 156 EP - 160 PB - Taylor & Francis, UK VL - 33 IS - 2 SN - 0142-159X, 0142-159X KW - Lectures KW - Psychopharmacology KW - Medical students KW - Antidepressant drugs KW - Games KW - Psychiatry KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855899919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Teacher&rft.atitle=Using+game+format+to+teach+psychopharmacology+to+medical+students&rft.au=Shiroma%2C+Paulo+R%3BMassa%2C+Alfredo+A%3BAlarcon%2C+Renato+D&rft.aulast=Shiroma&rft.aufirst=Paulo&rft.date=2011-01-01&rft.volume=33&rft.issue=2&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Medical+Teacher&rft.issn=0142159X&rft_id=info:doi/10.3109%2F0142159X.2010.509414 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-03-07 N1 - Last updated - 2016-09-27 N1 - CODEN - MEDTDX N1 - SubjectsTermNotLitGenreText - Games; Psychopharmacology; Lectures; Medical students; Antidepressant drugs; Psychiatry DO - http://dx.doi.org/10.3109/0142159X.2010.509414 ER - TY - JOUR T1 - Does Family History of Alcoholism Moderate Naltrexone's Effects on Alcohol Use? AN - 855899677; 201106876 AB - Objective: Primary outcomes from the COMBINE Study indicated support for naltrexone (Revia) on measures of abstinence and time to heavy drinking; however, effect sizes were modest The delineation of individual difference variables that qualify these results could aid efforts to target treatment approaches appropriately. Laboratory and clinical studies have found greater effectiveness of naltrexone among men and those with familial alcoholism. The present study used multilevel modeling to investigate family history of alcoholism (FHA) based on first-degree relatives and gender as moderators of naltrexone's effects on three drinking outcomes: percentage of days abstinent, drinks per drinking day, and percentage of heavy drinking days. Method: Data were drawn from the COMBINE public data set and included the subsample of participants (n = 603) randomized to receive active medication or placebo plus medical management. Results: We observed a main effect of FHA on drinks per drinking day (B = 2.01, SE = .91, p = .03) such that greater FHA was associated with greater alcohol use per drinking occasion. No other main effects of FHA were observed on drinking outcomes. A significant Naltrexone x Time interaction was observed for percentage of heavy drinking days (B = -1.61, SE = .69, p = .02), consistent with the previously published COMBINE results. No significant Naltrexone x FHA interactions were observed for any of the three outcomes. Gender did not modify these results. Conclusions: Taken together, these results indicate an effect of FHA on drinking behavior but do not support FHA among first-degree relatives as a moderator of naltrexone's efficacy in this sample. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Capone, Christy AU - Kahler, Christopher W AU - Swift, Robert M AU - O'Malley, Stephanie S AD - Mental Health and Behavioral Sciences Service (116B), Department of Veterans Affairs Medical Center, 830 Chalkstone Avenue, Providence, RI02908 christy.capone@va.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 135 EP - 140 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 72 IS - 1 SN - 1937-1888, 1937-1888 KW - Alcohol consumption KW - Alcoholism KW - Gender KW - Family histories KW - Naltrexone KW - Heavy drinking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855899677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Does+Family+History+of+Alcoholism+Moderate+Naltrexone%27s+Effects+on+Alcohol+Use%3F&rft.au=Capone%2C+Christy%3BKahler%2C+Christopher+W%3BSwift%2C+Robert+M%3BO%27Malley%2C+Stephanie+S&rft.aulast=Capone&rft.aufirst=Christy&rft.date=2011-01-01&rft.volume=72&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-03-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alcohol consumption; Naltrexone; Heavy drinking; Family histories; Gender; Alcoholism ER - TY - JOUR T1 - The Nurse Manager Forum in a Magnet^DTM Organization AN - 855899192; 201107230 AB - Nurse managers (NM) play an increasingly prominent role in achieving the goals of healthcare organizations and optimizing the patient and family experience of care. Robbins and Davidhizar1 note, 'The nurse manager must be a transformational leader capable of influencing staff to align with the organization's goals.' Concurrent with the NM role is an area of need identified by Zori and Morrison,2 who observe, 'Many nurse managers assume their position based on expertise in a clinical role with little expertise in managerial leadership skills.'. [Copyright Elsevier B.V.] JF - Nurse Leader AU - Gibson, Wanda H AU - Brown, Catherine M AU - Goucher, Ellen B Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 45 EP - 48 PB - Elsevier Ltd, The Netherlands VL - 9 IS - 1 SN - 1541-4612, 1541-4612 KW - Goals KW - Health care industry KW - Expertise KW - Nurse managers KW - Leadership KW - Work roles KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855899192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nurse+Leader&rft.atitle=The+Nurse+Manager+Forum+in+a+Magnet%5EDTM+Organization&rft.au=Gibson%2C+Wanda+H%3BBrown%2C+Catherine+M%3BGoucher%2C+Ellen+B&rft.aulast=Gibson&rft.aufirst=Wanda&rft.date=2011-01-01&rft.volume=9&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Nurse+Leader&rft.issn=15414612&rft_id=info:doi/10.1016%2Fj.mnl.2010.12.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-03-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nurse managers; Work roles; Expertise; Goals; Health care industry; Leadership DO - http://dx.doi.org/10.1016/j.mnl.2010.12.005 ER - TY - JOUR T1 - The Importance of the Peritraumatic Experience in Defining Traumatic Stress AN - 853207699; 201104980 AB - In the Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev., DSM-IV-TR; American Psychiatric Association, 2000), posttraumatic stress disorder (PTSD) Criterion A2 stipulates that an individual must experience intense fear, helplessness, or horror during an event that threatened the life or physical integrity of oneself or others to be eligible for the PTSD diagnosis. In considering this criterion, we describe its origins, review studies that have examined its predictive validity, and reflect on the intended purpose of the criterion and how it complements the mission of the DSM. We then assert that the predictive validity of Criterion A2 may not be an appropriate metric for evaluating its worth. We also note that the current Criterion A2 may not fully capture all the salient aspects of the traumatic stress response. To support this claim, we review empirical research showing that individuals adapt to extreme environmental events by responding in a complex and coordinated manner. This complex response set involves an individual's appraisal regarding the degree to which the event taxes his or her resources, as well as a range of other cognitions (e.g., dissociation), felt emotions (e.g., fear), physiological reactions (e.g., heart rate increase), and behaviors (e.g., tonic immobility). We provide evidence that these response components may be associated with the subsequent development of PTSD. We then describe the challenges associated with accurately assessing an individual's traumatic stress response. We conclude with a discussion of the need to consider the individual's immediate response when defining a traumatic stressor. [Copyright American Psychological Association] JF - Psychological Bulletin AU - Bovin, Michelle J AU - Marx, Brian P Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 47 EP - 67 PB - American Psychological Association, Washington DC VL - 137 IS - 1 SN - 0033-2909, 0033-2909 KW - PTSD trauma peritraumatic emotions appraisals peritraumatic behaviors KW - Posttraumatic stress disorder KW - Fear KW - Heart rate KW - Predictive validity KW - Traumatic stress KW - Helplessness KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853207699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Bulletin&rft.atitle=The+Importance+of+the+Peritraumatic+Experience+in+Defining+Traumatic+Stress&rft.au=Bovin%2C+Michelle+J%3BMarx%2C+Brian+P&rft.aulast=Bovin&rft.aufirst=Michelle&rft.date=2011-01-01&rft.volume=137&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Psychological+Bulletin&rft.issn=00332909&rft_id=info:doi/10.1037%2Fa0021353 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - CODEN - PSBUAI N1 - SubjectsTermNotLitGenreText - Traumatic stress; Posttraumatic stress disorder; Predictive validity; Fear; Heart rate; Helplessness DO - http://dx.doi.org/10.1037/a0021353 ER - TY - JOUR T1 - Stem cells in cardiac repair. AN - 820957820; 21174514 AB - Myocardial infarction is the leading cause of death among people in industrialized nations. Although the heart has some ability to regenerate after infarction, myocardial restoration is inadequate. Consequently, investigators are currently exploring the use of human embryonic stem cells (hESCs), skeletal myoblasts and adult bone marrow stem cells to limit infarct size. hESCs are pluripotent cells that can regenerate myocardium in infarcted hearts, attenuate heart remodeling and contribute to left ventricle (LV) systolic force development. Since hESCs can form heart teratomas, investigators are differentiating hESCs toward cardiac progenitor cells prior to transplantation into hearts. Large quantities of hESCs cardiac progenitor cells, however, must be generated, immune rejection must be prevented and grafts must survive over the long term to significantly improve myocardial performance. Transplanted autologous skeletal myoblasts can survive in infarcted myocardium in small numbers, proliferate, differentiate into skeletal myofibers and increase the LV ejection fraction. These cells, however, do not form electromechanical connections with host cardiomyocytes. Consequently, electrical re-entry can occur and cause cardiac arrhythmias. Autologous bone marrow mononuclear cells contain hematopoietic and mesenchymal stem cells. In several meta-analyses, patients with coronary disease who received autologous bone marrow cells by intracoronary injection show significant 3.7% (range: 1.9-5.4%) increases in LV ejection fraction, decreases in LV end-systolic volume of -4.8 ml (range: -1.4 to -8.2 ml) and reductions in infarct size of 5.5% (-1.9 to -9.1%), without experiencing arrhythmias. Bone marrow cells appear to release biologically active factors that limit myocardial damage. Unfortunately, bone marrow cells from patients with chronic diseases propagate poorly and can die prematurely. Substantial challenges must be addressed and resolved to advance the use of stem cells in cardiac repair including identifying the optimal stem cell(s) that permit transplantation without requirements for host immune suppression; timing of stem cell transplantation that maximizes chemoattraction of stem cells to infarcts; and determining the optimal technique for injecting stem cells for cardiac repair. Techniques must be developed to enhance survival and propagation of stem cells in the myocardium. These studies will require close cooperation and interaction of scientists and clinicians. Cell-based cardiac repair in the 21st century will offer new hope for millions of patients worldwide with myocardial infarctions who, otherwise, would suffer from the relentless progression of heart disease to heart failure and death. JF - Future cardiology AU - Henning, Robert J AD - James A. Haley VA Hospital/University of South Florida College of Medicine, Tampa, FL 33612, USA. robert.henning@va.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 99 EP - 117 VL - 7 IS - 1 KW - Index Medicus KW - Bone Marrow Cells KW - Ventricular Function, Left KW - Cord Blood Stem Cell Transplantation KW - Myoblasts, Skeletal -- transplantation KW - Humans KW - Myocardial Ischemia -- therapy KW - Pluripotent Stem Cells -- transplantation KW - Myocytes, Cardiac KW - Bone Marrow Transplantation KW - Stroke Volume KW - Myocardium -- cytology KW - Embryonic Stem Cells -- transplantation KW - Myocardium -- pathology KW - Myocardial Infarction -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/820957820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Future+cardiology&rft.atitle=Stem+cells+in+cardiac+repair.&rft.au=Henning%2C+Robert+J&rft.aulast=Henning&rft.aufirst=Robert&rft.date=2011-01-01&rft.volume=7&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Future+cardiology&rft.issn=1744-8298&rft_id=info:doi/10.2217%2Ffca.10.109 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-26 N1 - Date created - 2010-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2217/fca.10.109 ER - TY - JOUR T1 - Use of analogs of peptide hormones conjugated to cytotoxic radicals for chemotherapy targeted to receptors on tumors. AN - 816793954; 21034424 AB - Specific receptors for luteinizing hormone-releasing hormone (LH-RH), somatostatin, bombesin, and other peptides are found on various cancers. We review the development of cytotoxic analogs of LH-RH, somatostatin, and bombesin/gastrin releasing peptide (GRP) designed for targeting chemotherapy to peptide receptors on various cancers. Cytotoxic analogs of LH-RH, AN-152 and AN-207, containing doxorubicin (DOX) or 2-pyrrolino-DOX (AN-201), respectively, target LH-RH receptors and may be used for the treatment of prostatic and urinary bladder (urothelial), breast, ovarian and endometrial cancers, non-Hodgkin's lymphomas, melanomas, and renal cell carcinomas. DOX and AN-201 have also been incorporated into the cytotoxic analogs of somatostatin, AN-162 and AN-238, respectively, which are targeted to receptors for somatostatin in prostatic, mammary, ovarian, gastric, renal, colorectal and pancreatic cancers, non-Hodgkin's lymphomas, as well as glioblastomas and lung cancers. They are found to suppress the growth of these tumors and their metastases. A cytotoxic analog of bombesin/GRP, AN-215, containing 2-pyrrolino-Dox, has also been synthesized and shown to inhibit growth of various human cancer lines expressing receptors for bombesin/GRP. The toxicity, pharmacokinetics and maximum tolerated doses of AN-152 were assessed in a phase I clinical trial in women with ovarian or endometrial cancer. Disease stabilization and objective responses were found. Analog AN-152 is now in phase II clinical trials. Phase I/II studies with AN-152 in men with hormone-independent relapsed prostate cancer and patients with pancreatic and bladder cancers are pending. Targeted cytotoxic peptide analogs could provide a more efficacious and less toxic therapy for various cancers. JF - Current drug delivery AU - Schally, Andrew V AU - Engel, Jorg B AU - Emons, Gunter AU - Block, Norman L AU - Pinski, Jacek AD - Veterans Affairs Medical Center, 1201 NW 16th St, Miami, FL 33125, USA. Andrew.Schally@va.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 11 EP - 25 VL - 8 IS - 1 KW - Antineoplastic Agents KW - 0 KW - Peptide Hormones KW - Receptors, Peptide KW - Index Medicus KW - Animals KW - Humans KW - Clinical Trials as Topic KW - Neoplasms -- drug therapy KW - Peptide Hormones -- pharmacology KW - Receptors, Peptide -- metabolism KW - Peptide Hormones -- therapeutic use KW - Peptide Hormones -- chemistry KW - Molecular Targeted Therapy -- methods KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/816793954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+delivery&rft.atitle=Use+of+analogs+of+peptide+hormones+conjugated+to+cytotoxic+radicals+for+chemotherapy+targeted+to+receptors+on+tumors.&rft.au=Schally%2C+Andrew+V%3BEngel%2C+Jorg+B%3BEmons%2C+Gunter%3BBlock%2C+Norman+L%3BPinski%2C+Jacek&rft.aulast=Schally&rft.aufirst=Andrew&rft.date=2011-01-01&rft.volume=8&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Current+drug+delivery&rft.issn=1875-5704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-24 N1 - Date created - 2010-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Time Trends in Expenditures for Rural Veterans' Healthcare AN - 1081866802; 201237376 AB - We studied rural-urban differences in medical spending trends over eleven years for VA as well as non-VA care received by male veterans who used any VA services, and compared those trends to trends for other healthcare-using men. Using inflation-adjusted annual medical expenditures for non-veterans, VA users, and other veterans who participated in Medical Expenditure Panel Surveys from 1996 through 2006, we examined trends in spending on inpatient, hospital-based outpatient, office-based, pharmacy, and other care, by major payers (self/family, private insurance, Medicare, other sources, and VA), to assess changes in expenditures for the care of rural veterans, younger or older than 65 years, compared with other healthcare users. For all groups, spending for pharmacy and office-based care increased faster than inflation, while other care categories did not change consistently. VA spending also increased for these but not other services, and it grew sharply for working-age rural veterans, possibly reflecting improved access through community-based care. Adapted from the source document. JF - Journal of Rural Social Sciences AU - West, Alan N AU - Mackenzie, Todd A AD - VA Medical Center, White River Junction, VT alan.west@va.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 181 EP - 200 PB - Sam Houston State University, Dept of Sociology, Huntsville, TX VL - 26 IS - 3 SN - 2151-4178, 2151-4178 KW - Expenditures KW - Veterans KW - Males KW - Inflation KW - Access KW - Medicine KW - Pharmacy KW - Rural Areas KW - Health Care Services KW - article KW - 0623: complex organization; military sociology KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081866802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rural+Social+Sciences&rft.atitle=Time+Trends+in+Expenditures+for+Rural+Veterans%27+Healthcare&rft.au=West%2C+Alan+N%3BMackenzie%2C+Todd+A&rft.aulast=West&rft.aufirst=Alan&rft.date=2011-01-01&rft.volume=26&rft.issue=3&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rural+Social+Sciences&rft.issn=21514178&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Veterans; Expenditures; Rural Areas; Medicine; Health Care Services; Males; Pharmacy; Inflation; Access ER - TY - JOUR T1 - Interarytenoid Muscle Botox Iwjection for Treatment of Adductor Spasmodic Dysphonia With Vocal Tremor AN - 1030895142; 201210670 AB - Objectives/Hypothesis: Up to one-third of patients presenting with adductor spasmodic dysphonia will have an associated vocal tremor. These patients may not respond fully to treatment using thyroarytenoid (TA) muscle botulinum toxin (Botox) injection. Treatment failures are attributed to the involvement of multiple muscle groups in the tremor. This study evaluates the results of combined interarytenoid (IA) and TA muscle Botox injection in a group of 27 patients with adductor spasmodic dysphonia and vocal tremor and in four patients with severe vocal tremor alone. Study Design: Patient-satisfaction data were reviewed retrospectively. Pre- and postinjection acoustic data were collected prospectively. Methods: Acoustic measures of fundamental frequency and cycle-by-cycle variability in frequency (jitter) and intensity (shimmer) were obtained from 15 patients' sustained vowel productions. Measures were collected after TA muscle injection, alone, and after combined TA and IA (TA + IA) muscle injections. In addition, two experienced voice clinicians blindly assessed tremor severity from recordings made for each patient in the two conditions. Patients were also queried regarding their satisfaction with the results of the injections and whether they desired to continue receiving TA + IA treatment. Results: Significant improvement in all acoustic measures except for % jitter was observed after the TA + IA muscle injections. Listeners identified voice samples after TA + IA muscle injections as demonstrating less tremor in 73% of the paired comparisons. Sixty-seven percent of the patients with spasmodic dysphonia and vocal tremor wished to continue to receive IA muscle injections. Only one patient with severe vocal tremor wished to continue with injections. Conclusions: The addition of an IA muscle Botox injection to the treatment of patients with a combination adductor spasmodic dysphonia and vocal tremor may improve voice outcomes. Adapted from the source document JF - Journal of Voice AU - Kendall, Katherine A AU - Leonard, Rebecca J AD - Department of Otolaryngology, University of Minnesota, Minnesota katherine.kendall@va.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 114 EP - 119 VL - 25 IS - 1 SN - 0892-1997, 0892-1997 KW - Patients (62950) KW - Speech Pathology (82650) KW - Dysphonia (20270) KW - Voice Disorders (95150) KW - article KW - 6410: language-pathological and normal; language and speech pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030895142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Voice&rft.atitle=Interarytenoid+Muscle+Botox+Iwjection+for+Treatment+of+Adductor+Spasmodic+Dysphonia+With+Vocal+Tremor&rft.au=Kendall%2C+Katherine+A%3BLeonard%2C+Rebecca+J&rft.aulast=Kendall&rft.aufirst=Katherine&rft.date=2011-01-01&rft.volume=25&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Journal+of+Voice&rft.issn=08921997&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JOVOEA N1 - SubjectsTermNotLitGenreText - Patients (62950); Dysphonia (20270); Voice Disorders (95150); Speech Pathology (82650) ER - TY - JOUR T1 - Evaluation of an automated safety surveillance system using risk adjusted sequential probability ratio testing AN - 1024668490; 16863496 AB - Background: Automated adverse outcome surveillance tools and methods have potential utility in quality improvement and medical product surveillance activities. Their use for assessing hospital performance on the basis of patient outcomes has received little attention. We compared risk-adjusted sequential probability ratio testing (RA-SPRT) implemented in an automated tool to Massachusetts public reports of 30-day mortality after isolated coronary artery bypass graft surgery. Methods: A total of 23,020 isolated adult coronary artery bypass surgery admissions performed in Massachusetts hospitals between January 1, 2002 and September 30, 2007 were retrospectively re-evaluated. The RA-SPRT method was implemented within an automated surveillance tool to identify hospital outliers in yearly increments. We used an overall type I error rate of 0.05, an overall type II error rate of 0.10, and a threshold that signaled if the odds of dying 30-days after surgery was at least twice than expected. Annual hospital outlier status, based on the state-reported classification, was considered the gold standard. An event was defined as at least one occurrence of a higher-than-expected hospital mortality rate during a given year. Results: We examined a total of 83 hospital-year observations. The RA-SPRT method alerted 6 events among three hospitals for 30-day mortality compared with 5 events among two hospitals using the state public reports, yielding a sensitivity of 100% (5/5) and specificity of 98.8% (79/80). Conclusions: The automated RA-SPRT method performed well, detecting all of the true institutional outliers with a small false positive alerting rate. Such a system could provide confidential automated notification to local institutions in advance of public reporting providing opportunities for earlier quality improvement interventions. JF - BMC Medical Informatics and Decision Making AU - Matheny, Michael E AU - Normand, Sharon-Lise T AU - Gross, Thomas P AU - Marinac-Dabic, Danica AU - Loyo-Berrios, Nilsa AU - Vidi, Venkatesan D AU - Donnelly, Sharon AU - Resnic, Frederic S AD - GRECC and Center for Health Services Research, Tennessee Valley Healthcare System, Veterans Administration, Nashville, TN, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 75 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 11 IS - 1 SN - 1472-6947, 1472-6947 KW - Biotechnology and Bioengineering Abstracts KW - Classification KW - Decision making KW - Hospitals KW - Informatics KW - Medical equipment KW - Mortality KW - Quality control KW - Surgery KW - coronary artery KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1024668490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Medical+Informatics+and+Decision+Making&rft.atitle=Evaluation+of+an+automated+safety+surveillance+system+using+risk+adjusted+sequential+probability+ratio+testing&rft.au=Matheny%2C+Michael+E%3BNormand%2C+Sharon-Lise+T%3BGross%2C+Thomas+P%3BMarinac-Dabic%2C+Danica%3BLoyo-Berrios%2C+Nilsa%3BVidi%2C+Venkatesan+D%3BDonnelly%2C+Sharon%3BResnic%2C+Frederic+S&rft.aulast=Matheny&rft.aufirst=Michael&rft.date=2011-01-01&rft.volume=11&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=BMC+Medical+Informatics+and+Decision+Making&rft.issn=14726947&rft_id=info:doi/10.1186%2F1472-6947-11-75 L2 - http://www.biomedcentral.com/1472-6947/11/75 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Number of references - 15 N1 - Last updated - 2012-07-27 N1 - SubjectsTermNotLitGenreText - Decision making; Mortality; Classification; Medical equipment; Informatics; Quality control; Surgery; coronary artery; Hospitals DO - http://dx.doi.org/10.1186/1472-6947-11-75 ER - TY - JOUR T1 - Accelerated Weight Loss and Incident Dementia in an Elderly African-American Cohort AN - 1011205734; 14224760 AB - OBJECTIVES: To examine the association between changes in body mass index (BMI), dementia, and mild cognitive impairment (MCI). DESIGN: Prospective observational study. SETTING: Urban community in Indianapolis, Indiana. PARTICIPANTS: Participants were African Americans aged 65 and older enrolled in the Indianapolis Dementia Project and followed through 2007. This analysis included 1,331 participants who did not have dementia at their first BMI measurement. MEASUREMENTS: Cognitive assessment and clinical evaluations were conducted every other year to identify participants with dementia or MCI during 12 years of follow-up (mean follow-up 6.4 years). BMI measures; alcohol and smoking history; and medical conditions including history of cancer, hypertension, diabetes mellitus, heart attack, stroke; and depression were collected at each follow-up evaluation. Mixed-effect models were used to examine the differences in BMI between participants who developed dementia or MCI and those who did not, adjusting for covariates. RESULTS: Mean BMI at baseline was 29.8 +/- 5.7 for women and 28.3 +/- 4.8 for men. Participants with incident dementia or MCI had greater decline in BMI than those without (P=.02 for dementia, P=.04 for MCI). BMI in participants with incident dementia, MCI, and normal cognition did not differ 12 or 9 years before diagnosis, but 6 years before diagnosis, participants with incident dementia had significantly lower BMI than participants with normal cognition (P=.03), as did participants with MCI (P=.006). CONCLUSION: Decline in BMI appears to be an early marker for dementia. There is a need for the close monitoring of weight loss in older adults. JF - Journal of the American Geriatrics Society AU - Gao, Sujuan AU - Nguyen, James T AU - Hendrie, Hugh C AU - Unverzagt, Frederick W AU - Hake, Ann AU - Smith-Gamble, Valerie AU - Hall, Kathleen AD - From the Departments of*Medicine, Psychiatry, and [par]Neurology, School of Medicine, Indiana University, Indianapolis, Indiana; Indiana University Center for Aging Research, Indianapolis, Indiana; Regenstrief Institute, Inc., Indianapolis, Indiana; and #Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, Indiana. Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 18 EP - 25 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 59 IS - 1 SN - 0002-8614, 0002-8614 KW - Physical Education Index KW - Alzheimer's disease KW - Body mass KW - Cognition KW - Evaluation KW - Geriatrics KW - Gerontology KW - Health (history) KW - Measurement KW - Weight control KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011205734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Accelerated+Weight+Loss+and+Incident+Dementia+in+an+Elderly+African-American+Cohort&rft.au=Gao%2C+Sujuan%3BNguyen%2C+James+T%3BHendrie%2C+Hugh+C%3BUnverzagt%2C+Frederick+W%3BHake%2C+Ann%3BSmith-Gamble%2C+Valerie%3BHall%2C+Kathleen&rft.aulast=Gao&rft.aufirst=Sujuan&rft.date=2011-01-01&rft.volume=59&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2010.03169.x LA - English DB - Physical Education Index N1 - Date revised - 2012-05-01 N1 - Document feature - figure 1 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Evaluation; Measurement; Weight control; Body mass; Alzheimer's disease; Geriatrics; Gerontology; Health (history); Cognition DO - http://dx.doi.org/10.1111/j.1532-5415.2010.03169.x ER - TY - JOUR T1 - Teaching strategies used by internal medicine residents on the wards AN - 1010709471; 201209540 AB - Background: Residents serve as teachers to interns and students in most internal medicine residency programs. Aim: The purpose of our study is to explore what internal medicine residents perceive as effective teaching strategies in the inpatient setting and to formulate a guideline for preparing residents to lead their ward teams. Methods: Housestaff identified as excellent teaching residents were recruited from a large internal medicine residency program. Focus groups were formed and interviews were conducted using open-ended questions. Transcripts of the interviews were reviewed, analyzed, and compared for accuracy by two investigators. The transcripts were then coded to categorize data into similar subjects from which recurrent themes in resident teaching were identified. Results: Twenty-two residents participated in four focus group interviews held in 2008. We identified five principal themes for effective teaching by residents: (T)aking advantage of teaching opportunities, (E)mpowering learners, (A)ssuming the role of leader, (C)reating a learning environment, and (H)abituating the practice of teaching. Adapted from the source document. JF - Medical Teacher AU - Smith, Dustin T AU - Kohlwes, R Jeffrey AD - Emory University School of Medicine and Morehouse School of Medicine, USA dustin.smith2@va.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - e697 EP - e703 PB - Informa Healthcare VL - 33 IS - 12 SN - 0142-159X, 0142-159X KW - Teams KW - Teaching KW - House officers KW - Teaching methods KW - Teachers KW - Medical education KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010709471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Teacher&rft.atitle=Teaching+strategies+used+by+internal+medicine+residents+on+the+wards&rft.au=Smith%2C+Dustin+T%3BKohlwes%2C+R+Jeffrey&rft.aulast=Smith&rft.aufirst=Dustin&rft.date=2011-01-01&rft.volume=33&rft.issue=12&rft.spage=e697&rft.isbn=&rft.btitle=&rft.title=Medical+Teacher&rft.issn=0142159X&rft_id=info:doi/10.3109%2F0142159X.2011.611838 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - MEDTDX N1 - SubjectsTermNotLitGenreText - Teaching; Teaching methods; House officers; Medical education; Teachers; Teams DO - http://dx.doi.org/10.3109/0142159X.2011.611838 ER - TY - JOUR T1 - Reduction in Physician Reimbursement and Use of Hormone Therapy in Prostate Cancer AN - 954613866; 14087377 AB - Background Use of androgen suppression therapy (AST) in prostate cancer increased more than threefold from 1991 to 1999. The 2003 Medicare Modernization Act reduced reimbursements for AST by 64% between 2004 and 2005, but the effect of this large reduction on use of AST is unknown. Methods A cohort of 72818 men diagnosed with prostate cancer in 1992-2005 was identified from the Surveillance, Epidemiology, and End Results database. From Medicare claims data, indicated AST was defined as 3 months or more of AST in the first year in men with metastatic disease (n = 8030). Non-indicated AST was defined as AST given without other therapies such as radical prostatectomy or radiation in men with low-risk disease (n = 64788). The unadjusted annual proportion of men receiving AST was plotted against the median Medicare AST reimbursement. A multivariable model was used to estimate the odds of AST use in men with low-risk and metastatic disease, with the predictor of interest being the calendar year of the payment change. Covariates in the model included age in 5-year categories, clinical tumor stage (T1-T4), World Health Organization grade (1-3, unknown), Charlson comorbidity (0, 1, 2, greater than or equal to 3), race, education, income, and tumor registry site, all as categorical variables. The models included variations in the definition of AST use ( greater than or equal to 1, greater than or equal to 3, and greater than or equal to 6 months of AST). All statistical tests were two-sided. Results AST use in the low-risk group peaked at 10.2% in 2003, then declined to 7.1% in 2004 and 6.1% in 2005. After adjusting for tumor and demographic covariates, the odds of receiving non-indicated primary AST decreased statistically significantly in 2004 (odds ratio [OR] = 0.70, 95% confidence interval = 0.61 to 0.80) and 2005 (OR = 0.61, 95% confidence interval = 0.53 to 0.71) compared with 2003. AST use in the metastatic disease group was stable at 60% during the payment change, and the adjusted odds ratio of receiving AST in this group was unchanged in 2004-2005. Conclusions In this example of hormone therapy for prostate cancer, decreased physician reimbursement was associated with a reduction in overtreatment without a reduction in needed services. JF - Journal of the National Cancer Institute AU - Elliott, Sean P AU - Jarosek, Stephanie L AU - Wilt, Timothy J AU - Virnig, Beth A AD - Affiliations of authors: Department of Urologic Surgery, School of Medicine (SPE) and Division of Health Policy and Management, School of Public Health (SPE, SLJ, BAV) and Masonic Cancer Center (SPE, BAV) and Department of Medicine, School of Medicine (TJW), University of Minnesota, Minneapolis, MN; The Center for Chronic Disease Outcomes Research, Veterans Administration Medical Center, Minneapolis, MN (TJW), selliott@umn.edu Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 1826 EP - 1834 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 24 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - demography KW - Age KW - tumors KW - Hormones KW - Cancer KW - Morbidity KW - Education KW - income KW - prostate cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954613866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Reduction+in+Physician+Reimbursement+and+Use+of+Hormone+Therapy+in+Prostate+Cancer&rft.au=Elliott%2C+Sean+P%3BJarosek%2C+Stephanie+L%3BWilt%2C+Timothy+J%3BVirnig%2C+Beth+A&rft.aulast=Elliott&rft.aufirst=Sean&rft.date=2010-12-15&rft.volume=102&rft.issue=24&rft.spage=1826&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq417 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - demography; Age; Education; income; tumors; prostate cancer; Hormones; Morbidity; Cancer DO - http://dx.doi.org/10.1093/jnci/djq417 ER - TY - JOUR T1 - Therapy Response Evaluation with Positron Emission Tomography-Computed Tomography AN - 954630036; 14255852 AB - Positron emission tomography-computed tomography with F-18-fluorodeoxyglucose is widely used for evaluation of therapy response in patients with solid tumors but has not been as readily adopted in clinical trials because of the variability of acquisition and processing protocols and the absence of universal response criteria. Criteria proposed for clinical trials are difficult to apply in clinical practice, and gestalt impression is probably accurate in individual patients, especially with respect to the presence of progressive disease and complete response. Semiquantitative methods of determining tissue glucose metabolism, such as standard uptake value, can be a useful descriptor for levels of tissue glucose metabolism and changes in response to therapy if technical quality control measures are carefully maintained. The terms partial response, complete response, and progressive disease are best used in clinical trials in which the terms have specific meanings and precise definitions. In clinical practice, it may be better to use descriptive terminology agreed upon by imaging physicians and clinicians in their own practice. JF - Seminars in Ultrasound, CT & MRI AU - Segall, George M Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 490 EP - 495 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 31 IS - 6 SN - 0887-2171, 0887-2171 KW - Biotechnology and Bioengineering Abstracts KW - Solid tumors KW - Quality control KW - Magnetic resonance imaging KW - Computed tomography KW - Tomography KW - Glucose metabolism KW - Clinical trials KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954630036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Ultrasound%2C+CT+%26+MRI&rft.atitle=Therapy+Response+Evaluation+with+Positron+Emission+Tomography-Computed+Tomography&rft.au=Segall%2C+George+M&rft.aulast=Segall&rft.aufirst=George&rft.date=2010-12-01&rft.volume=31&rft.issue=6&rft.spage=490&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Ultrasound%2C+CT+%26+MRI&rft.issn=08872171&rft_id=info:doi/10.1053%2Fj.sult.2010.10.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Solid tumors; Quality control; Computed tomography; Magnetic resonance imaging; Tomography; Glucose metabolism; Ultrasound; Clinical trials DO - http://dx.doi.org/10.1053/j.sult.2010.10.007 ER - TY - JOUR T1 - Body Mass Index Is Associated With Brain Metabolite Levels in Alcohol Dependence-A Multimodal Magnetic Resonance Study AN - 954591352; 14098271 AB - Background: Recent studies demonstrated that alcohol dependence and excessive alcohol consumption are associated with increased rates of obesity. In healthy light-drinkers, we and others have observed associations between elevated body mass index (BMI) and reductions in brain volumes, lower concentrations of N-acetyl-aspartate (NAA, marker of neuronal viability) and choline-containing compounds (Cho, involved in membrane turnover), and lower glucose utilization, particularly in frontal lobe-a brain region that is particularly vulnerable to the effects of alcohol dependence. Here, we evaluated whether BMI in alcohol-dependent individuals was independently associated with regional measures of brain structure, metabolite concentrations, and neocortical blood flow.Methods: As part of a study on the effects of alcohol dependence on neurobiology, we analyzed retrospectively data from 54 alcohol-dependent males, abstinent from alcohol for about 1 month and with BMI between 20 and 37 kg-m2 by structural MRI, perfusion MRI (blood flow), and proton magnetic resonance spectroscopic imaging.Results: After correction for age, smoking status, and various measures of alcohol consumption, higher BMI was associated with lower concentrations of NAA, Cho, creatine and phosphocreatine (Cr, involved in high energy metabolism), and myo-inositol (m-Ino, a putative marker of astrocytes) primarily in the frontal lobe, in subcortical nuclei, and cerebellar vermis (p < 0.004). Regional brain volumes and perfusion were not significantly related to BMI. Furthermore, comorbid conditions, clinical laboratory measures, and nutritional assessments were not significant predictors of these MR-based measures.Conclusions: The results suggest that BMI, independent of age, alcohol consumption, and common comorbidities, is related to regional NAA, Cho, Cr, and m-Ino concentrations in this cohort of alcohol-dependent individuals. Additionally, as some common comorbid conditions in alcohol dependence such as cigarette smoking are associated with BMI, their associations with regional brain metabolite levels in alcohol-dependent individuals may also be influenced by BMI. JF - Alcoholism: Clinical and Experimental Research AU - Gazdzinski, Stefan AU - Durazzo, Timothy C AU - Mon, Anderson AU - Meyerhoff, Dieter J AD - From the Center for Imaging of Neurodegenerative Diseases (SG), San Francisco Veterans Administration Medical Center, San Francisco, California; Marian Smoluchowski Institute of Physics (SG), Jagiellonian University, Krakow, Poland; Department of Radiology and Biomedical Imaging (TCD, AM, DJM), University of California San Francisco; and Center for Imaging of Neurodegenerative Diseases (TCD, AM, DJM), San Francisco Veterans Administration Medical Center, San Francisco, California. Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 2089 EP - 2096 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 34 IS - 12 SN - 0145-6008, 0145-6008 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Age KW - Alcoholics KW - Alcoholism KW - Astrocytes KW - Body mass index KW - Brain KW - Cerebellum KW - Cigarette smoking KW - Cortex KW - Creatine KW - Data processing KW - Drug abuse KW - Drug dependence KW - Energy metabolism KW - Ethanol KW - Frontal lobe KW - Glucose metabolism KW - Magnetic resonance imaging KW - Magnetic resonance spectroscopy KW - Membrane turnover KW - Metabolites KW - N.M.R. KW - Nervous system KW - Obesity KW - Perfusion KW - Phosphocreatine KW - X 24380:Social Poisons & Drug Abuse KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954591352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%3A+Clinical+and+Experimental+Research&rft.atitle=Body+Mass+Index+Is+Associated+With+Brain+Metabolite+Levels+in+Alcohol+Dependence-A+Multimodal+Magnetic+Resonance+Study&rft.au=Gazdzinski%2C+Stefan%3BDurazzo%2C+Timothy+C%3BMon%2C+Anderson%3BMeyerhoff%2C+Dieter+J&rft.aulast=Gazdzinski&rft.aufirst=Stefan&rft.date=2010-12-01&rft.volume=34&rft.issue=12&rft.spage=2089&rft.isbn=&rft.btitle=&rft.title=Alcoholism%3A+Clinical+and+Experimental+Research&rft.issn=01456008&rft_id=info:doi/10.1111%2Fj.1530-0277.2010.01305.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Number of references - 67 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Age; Membrane turnover; Astrocytes; Magnetic resonance imaging; Cerebellum; Creatine; Metabolites; Glucose metabolism; Drug abuse; Nervous system; Cortex; Magnetic resonance spectroscopy; Cigarette smoking; N.M.R.; Ethanol; Obesity; Perfusion; Data processing; Energy metabolism; Brain; Alcoholics; Drug dependence; Phosphocreatine; Frontal lobe; Alcoholism; Body mass index DO - http://dx.doi.org/10.1111/j.1530-0277.2010.01305.x ER - TY - JOUR T1 - Sexual Self-Schemas of Female Child Sexual Abuse Survivors: Relationships with Risky Sexual Behavior and Sexual Assault in Adolescence AN - 904466224; 14238196 AB - Childhood sexual trauma has been demonstrated to increase survivors' risk for engaging in unrestricted sexual behaviors and experiencing adolescent sexual assault. The current study used the sexual self-schema construct to examine cognitive representations of sexuality that might drive these behavioral patterns. In Study 1 (N=774), we attempted to improve the content validity of the Sexual Self Schema Scale for child sexual abuse (CSA) survivors, introducing a fourth sexual self-schema factor titled the "immoral/irresponsible" factor. In Study 2 (N=1150), the potential differences in sexual self-views, as assessed by the four sexual self-schema factors, between CSA survivors and non-victims were explored. In addition, Study 2 evaluated how these sexual self-schema differences may contribute to participation in unrestricted sexual behaviors and risk for sexual assault in adolescence. Results indicated that a history of CSA impacted the way women viewed themselves as a sexual person on each of the four factors. CSA survivors were found to view themselves as more open and possessing more immoral/irresponsible cognitions about sexuality as compared to women who did not have a CSA history. In addition, the CSA survivors endorsed less embarrassment and passionate/romantic views of their sexual selves. The interaction of CSA severity and the sexual self-schemas explained variance in adolescent sexual assault experiences above and beyond the severity of CSA history and participation in risky sexual behaviors. The findings suggest that sexual self-views may serve to moderate the relationship between CSA and adolescent sexual assault. Implications of these findings and directions for future research are discussed. JF - Archives of Sexual Behavior AU - Niehaus, Ashley F AU - Jackson, Joan AU - Davies, Stephanie AD - Psychology Service (116B), Boston VA Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA, ashley.niehaus@va.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1359 EP - 1374 PB - Springer New York, LLC, 233 Spring St New York NY 10013-1578 USA VL - 39 IS - 6 SN - 0004-0002, 0004-0002 KW - Risk Abstracts KW - sexual behavior KW - Historical account KW - child abuse KW - Children KW - sexual assault KW - cognitive ability KW - Females KW - Adolescents KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904466224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Sexual+Behavior&rft.atitle=Sexual+Self-Schemas+of+Female+Child+Sexual+Abuse+Survivors%3A+Relationships+with+Risky+Sexual+Behavior+and+Sexual+Assault+in+Adolescence&rft.au=Niehaus%2C+Ashley+F%3BJackson%2C+Joan%3BDavies%2C+Stephanie&rft.aulast=Niehaus&rft.aufirst=Ashley&rft.date=2010-12-01&rft.volume=39&rft.issue=6&rft.spage=1359&rft.isbn=&rft.btitle=&rft.title=Archives+of+Sexual+Behavior&rft.issn=00040002&rft_id=info:doi/10.1007%2Fs10508-010-9600-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Historical account; sexual behavior; cognitive ability; child abuse; Females; Children; sexual assault; Adolescents DO - http://dx.doi.org/10.1007/s10508-010-9600-9 ER - TY - JOUR T1 - Acute stress reaction and completed suicide AN - 872125568; 14086932 AB - Background Acute stress reaction is a diagnosis given immediately following the experience of an exceptional mental or physical stressor. To the best of our knowledge, no study has examined the association between acute stress reaction diagnosis and suicide. The current study examined this association in a population-based sample. In addition, we examined comorbid psychiatric diagnoses as modifiers of this association.Methods Data for the current study were obtained from the nationwide Danish health and administrative registries, which include data for all 5.4 million residents of Denmark. All suicides between 1 January 1994 and 31 December 2006 were included and controls were selected from a sample of all Danish residents. Using this nested case-control design, we examined 9612 suicide cases and 199 306 controls matched to cases with respect to gender, date of birth and time.Results In total, 95 cases (0.99%) and 165 controls (0.08%) had a diagnosis of acute stress reaction. Those diagnosed with acute stress reaction had 10 times the rate of completed suicide compared with those without this diagnosis, adjusting for the control to case matching, depression and marital status (95% confidence interval 7.7-14). Additionally, persons with acute stress reaction and depression, or acute stress reaction and substance abuse, had a greater rate of suicide than expected based on their independent effects.Conclusions Acute stress reaction is a risk factor for completed suicide. JF - International Journal of Epidemiology AU - Gradus, Jaimie L AU - Qin, Ping AU - Lincoln, Alisa K AU - Miller, Matthew AU - Lawler, Elizabeth AU - Soerensen, Henrik Toft AU - Lash, Timothy L AD - super(1)National Center for PTSD, VA Boston Healthcare System and Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA, super(2)Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA, super(3)National Centre for Register-based Research, Aarhus University, Aarhus, Denmark, super(4)Health Sciences and Sociology Departments, Northeastern University, Boston, MA, USA, super(5)Department of Health Policy and Management, Harvard University School of Public Health, Boston, MA, USA, super(6)Department of Medicine, Harvard University, Boston, MA, USA and super(7)Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark, jaimie.gradus@va.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1478 EP - 1484 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 39 IS - 6 SN - 0300-5771, 0300-5771 KW - Risk Abstracts KW - Gender KW - Stress KW - depression KW - marriage KW - substance abuse KW - suicide KW - Denmark KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872125568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Epidemiology&rft.atitle=Acute+stress+reaction+and+completed+suicide&rft.au=Gradus%2C+Jaimie+L%3BQin%2C+Ping%3BLincoln%2C+Alisa+K%3BMiller%2C+Matthew%3BLawler%2C+Elizabeth%3BSoerensen%2C+Henrik+Toft%3BLash%2C+Timothy+L&rft.aulast=Gradus&rft.aufirst=Jaimie&rft.date=2010-12-01&rft.volume=39&rft.issue=6&rft.spage=1478&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Epidemiology&rft.issn=03005771&rft_id=info:doi/10.1093%2Fije%2Fdyq112 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2013-02-22 N1 - SubjectsTermNotLitGenreText - substance abuse; Gender; Stress; marriage; depression; suicide; Denmark DO - http://dx.doi.org/10.1093/ije/dyq112 ER - TY - JOUR T1 - Electronic Health Information in Use: Characteristics That Support Employee Workflow and Patient Care AN - 862594288; 201103428 AB - The aim of this investigation was to assess helpful and challenging aspects of electronic health information with respect to clinical workflow and identify a set of characteristics that support patient care processes. We conducted 20 semi-structured interviews at a Veterans Affairs Medical Center, with a fully implemented electronic health record (EHR), and elicited positive and negative examples of how information technology (IT) affects the work of healthcare employees. Responses naturally shed light on information characteristics that aid work processes. We performed a secondary analysis on interview data and inductively identified characteristics of electronic information that support healthcare workflow. Participants provided 199 examples of how electronic information affects workflow. Seventeen characteristics emerged along with four primary domains: trustworthy and reliable; ubiquitous; effectively displayed; and adaptable to work demands. Each characteristic may be used to help evaluate health information technology pre- and post-implementation. Results provide several strategies to improve EHR design and implementation to better support healthcare workflow. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Health Informatics Journal AU - Russ, Alissa L AU - Saleem, Jason J AU - Justice, Connie F AU - Woodward-Hagg, Heather AU - Woodbridge, Peter A AU - Doebbeling, Bradley N AD - VA HSR&D Center of Excellence on Implementing Evidenced-eased Practice (CIEBP), Richard L Roudebush VA Medical Center, 1481 West 10th Street (II-H), Indianapolis, IN 46202, USA alissa.russ@va.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 287 EP - 305 PB - Sage Publications, Thousand Oaks CA VL - 16 IS - 4 SN - 1460-4582, 1460-4582 KW - Data display, electronic health record, human factors, medical informatics applications KW - Human aspects KW - Computerized records management KW - Medical informatics KW - article KW - 18.0: RECORDS MANAGEMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862594288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Informatics+Journal&rft.atitle=Electronic+Health+Information+in+Use%3A+Characteristics+That+Support+Employee+Workflow+and+Patient+Care&rft.au=Russ%2C+Alissa+L%3BSaleem%2C+Jason+J%3BJustice%2C+Connie+F%3BWoodward-Hagg%2C+Heather%3BWoodbridge%2C+Peter+A%3BDoebbeling%2C+Bradley+N&rft.aulast=Russ&rft.aufirst=Alissa&rft.date=2010-12-01&rft.volume=16&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Health+Informatics+Journal&rft.issn=14604582&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Computerized records management; Medical informatics; Human aspects ER - TY - JOUR T1 - Management of Insomnia in the Geriatric Patient AN - 853487661; 14255906 AB - Insomnia in older individuals is common and often undiagnosed, and can lead to significant patient morbidity. A stepwise, thorough history and physical examination, including interviews with the bed partner and use of a sleep diary, are valuable diagnostic adjuncts. Polysomnography should be reserved for patients whose history suggests specific sleep-related breathing or movement disorders of breathing. Contributing physical or psychiatric conditions require treatment as in other geriatric patients. Improved sleep hygiene will often provide symptom relief in mild to moderate insomnia, whereas a number of non-drug treatments can be tried for more refractory cases. Most prescription and over-the-counter medications carry significant risk of adverse events and drug interactions; others demonstrate an acceptable risk to benefit profile and are preferred in older patients. JF - American Journal of Medicine AU - Roszkowska, Jolanta AU - Geraci, Stephen A AD - Division of Geriatric Medicine, Department of Internal Medicine, University of Mississippi School of Medicine, Jackson, Miss, Jolanta.Roszkowska@va.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1087 EP - 1090 PB - Elsevier BV, PO Box 10670 Riverton, NJ 08076 USA VL - 123 IS - 12 SN - 0002-9343, 0002-9343 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Elderly KW - Morbidity KW - Sleep KW - Hygiene KW - Drugs KW - drug interaction KW - Side effects KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853487661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Medicine&rft.atitle=Management+of+Insomnia+in+the+Geriatric+Patient&rft.au=Roszkowska%2C+Jolanta%3BGeraci%2C+Stephen+A&rft.aulast=Roszkowska&rft.aufirst=Jolanta&rft.date=2010-12-01&rft.volume=123&rft.issue=12&rft.spage=1087&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Medicine&rft.issn=00029343&rft_id=info:doi/10.1016%2Fj.amjmed.2010.04.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Historical account; Sleep; Elderly; Hygiene; Drugs; Morbidity; Side effects; drug interaction DO - http://dx.doi.org/10.1016/j.amjmed.2010.04.006 ER - TY - JOUR T1 - Deep brain stimulation of the amygdala alleviates post-traumatic stress disorder symptoms in a rat model AN - 853208336; 201105698 AB - Post-traumatic stress disorder (PTSD) is an anxiety disorder triggered by a life-threatening event causing intense fear. Recently, functional neuroimaging studies have suggested that amygdala hyperactivity is responsible for the symptoms of PTSD. Deep brain stimulation (DBS) can functionally reduce the activity of a cerebral target by delivering an electrical signal through an electrode. We tested whether DBS of the amygdala could be used to treat PTSD symptoms. Rats traumatized by inescapable shocks, in the presence of an unfamiliar object, develop the tendency to bury the object when re-exposed to it several days later. This behavior mimics the symptoms of PTSD. 10 Sprague-Dawley rats underwent the placement of an electrode in the right basolateral nucleus of the amygdala (BLn). The rats were then subjected to a session of inescapable shocks while being exposed to a conspicuous object (a ball). Five rats received DBS treatment while the other 5 rats did not. After 7 days of treatment, the rats were re-exposed to the ball and the time spent burying it under the bedding was recorded. Rats treated with BLn DBS spent on average 13 times less time burying the ball than the sham control rats. The treated rats also spent 18 times more time exploring the ball than the sham control rats. In conclusion, the behavior of treated rats in this PTSD model was nearly normalized. We argue that these results have direct implications for patients suffering from treatment-resistant PTSD by offering a new therapeutic strategy. [Copyright Elsevier Ltd.] JF - Journal of Psychiatric Research AU - Langevin, Jean-Philippe AU - De Salles, Antonio A F AU - Kosoyan, Hovsep P AU - Krahl, Scott E AD - Division of Neurosurgery, University of Arizona, PO Box 245070, 1501 N Campbell Avenue, Room 4310, Tucson, AZ 85724-5070, USA jean-philippe.langevin@va.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 1241 EP - 1245 PB - Elsevier Ltd, Oxford UK VL - 44 IS - 16 SN - 0022-3956, 0022-3956 KW - Deep brain stimulation Amygdala Post-traumatic stress disorder Basolateral nucleus Fear Functional imaging KW - Rats KW - Symptoms KW - Posttraumatic stress disorder KW - Stimulation KW - Balls KW - Brain KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853208336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychiatric+Research&rft.atitle=Deep+brain+stimulation+of+the+amygdala+alleviates+post-traumatic+stress+disorder+symptoms+in+a+rat+model&rft.au=Langevin%2C+Jean-Philippe%3BDe+Salles%2C+Antonio+A+F%3BKosoyan%2C+Hovsep+P%3BKrahl%2C+Scott+E&rft.aulast=Langevin&rft.aufirst=Jean-Philippe&rft.date=2010-12-01&rft.volume=44&rft.issue=16&rft.spage=1241&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychiatric+Research&rft.issn=00223956&rft_id=info:doi/10.1016%2Fj.jpsychires.2010.04.022 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - CODEN - JPYRA3 N1 - SubjectsTermNotLitGenreText - Rats; Posttraumatic stress disorder; Symptoms; Balls; Stimulation; Brain DO - http://dx.doi.org/10.1016/j.jpsychires.2010.04.022 ER - TY - JOUR T1 - Longitudinal Risk Factors for Intimate Partner Violence Among Men in Treatment for Alcohol Use Disorders AN - 839576574; 201104133 AB - Objective: This study examined static and time-varying risk factors for perpetration of intimate partner violence (IPV) among men in treatment for alcohol use disorders. Method: Participants were 178 men diagnosed with alcohol abuse or dependence and their partners. Most (85%) of the men were European American; their average age was 41.0 years. Participants completed measures assessing initial alcohol problem severity, baseline beliefs related to alcohol use, antisocial personality characteristics, alcohol and drug use, relationship adjustment, and IPV. Results: According to couples' reconciled reports, 42% of participants perpetrated IPV at baseline. Among this group, the IPV recurrence rate was 43% at 6-month follow-up and 36% at 12-month follow-up. For participants without IPV perpetration at baseline, new incidence of IPV was 15% and 7% at the 6-month and 12-month follow-up points, respectively. Fixed marker predictors of IPV rates included baseline alcohol problem severity variables, baseline beliefs related to alcohol use, and antisocial personality characteristics. Variable risk factor predictors included alcohol and drug use variables, relationship adjustment factors, and anger. Alcohol use variables and anger were associated with new incidents of IPV among those without reported IPV at baseline only. Conclusions: Findings suggest that assessing and monitoring IPV occurrence by both partners is important for men in treatment for alcohol use disorders. Results indicate vulnerability factors that may identify individuals at risk for IPV and provide targets for IPV prevention among those with alcohol use disorders. These findings can aid in the development of more comprehensive models that more precisely predict IPV. [Copyright American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Taft, Casey T AU - O'Farrell, Timothy J AU - Doron-Lamarca, Susan AU - Panuzio, Jillian AU - Suvak, Michael K AU - Gagnon, David R AU - Murphy, Christopher M Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 924 EP - 935 PB - American Psychological Association, Washington DC VL - 78 IS - 6 SN - 0022-006X, 0022-006X KW - partner violence alcohol and drug use antisocial personality relationship adjustment anger KW - Alcohol consumption KW - Men KW - Abusive relationships KW - Risk factors KW - Alcohol related disorders KW - Alcoholics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839576574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=Longitudinal+Risk+Factors+for+Intimate+Partner+Violence+Among+Men+in+Treatment+for+Alcohol+Use+Disorders&rft.au=Taft%2C+Casey+T%3BO%27Farrell%2C+Timothy+J%3BDoron-Lamarca%2C+Susan%3BPanuzio%2C+Jillian%3BSuvak%2C+Michael+K%3BGagnon%2C+David+R%3BMurphy%2C+Christopher+M&rft.aulast=Taft&rft.aufirst=Casey&rft.date=2010-12-01&rft.volume=78&rft.issue=6&rft.spage=924&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2Fa0021093 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Abusive relationships; Men; Alcohol consumption; Alcohol related disorders; Risk factors; Alcoholics DO - http://dx.doi.org/10.1037/a0021093 ER - TY - JOUR T1 - Smoking-Cessation Strategies for American Indians: Should Smoking-Cessation Treatment Include a Prescription for a Complete Home Smoking Ban? AN - 839570807; 201101362 AB - Background: The prevalence of cigarette smoking is particularly high among American Indian communities in the Upper Midwest. Purpose: To evaluate the predictors of smoking cessation among a population-based sample of American Indians in the Upper Midwest during a quit attempt aided with nicotine replacement therapy (NRT). Methods: This study used the subsample of American Indian adults (n=291, response rate=55.4%) from a cohort study of smokers engaging in an aided NRT quit attempt. Eligible participants filled an NRT prescription between July 2005 and September 2006 through the Minnesota Health Care Programs (e.g., Medicaid). Administrative records and follow-up survey data were used to assess outcomes approximately 8 months after the NRT fill date. This analysis was conducted in 2009-2010. Results: Approximately 33% of American Indian respondents trying to quit smoking reported complete home smoking bans. Adoption of a complete home smoking ban and greater perceived advantages of NRT were cross-sectionally associated with 7-day smoking abstinence in univariate and multivariate analyses. Consistent with previous research, older age was a significant predictor of 7-day abstinence. Having a history of clinician-diagnosed anxiety in the past year was associated with decreased likelihood of 7-day abstinence in the unadjusted analysis, but not significant in multivariate analyses. Conclusions: Results of this study suggest potential modifiable targets of interventions for future research to help American Indians quit smoking: (1) improved delivery of behavioral interventions to increase the intensity of smoking cessation treatment; (2) promotion and adoption of complete home smoking bans; and (3) education to increase awareness of the benefits of NRT. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Fu, Steven S AU - Burgess, Diana J AU - van Ryn, Michele AU - Rhodes, Kris AU - Widome, Rachel AU - Ricards, Jennifer J AU - Noorbaloochi, Siamak AU - Clothier, Barbara AU - Su, Jennifer AU - Joseph, Anne M AD - VA Health Services Research & Development Service Center Chronic Disease Outcomes Research, Dept Veterans Affairs Medical Center, Minneapolis, MN steven.fu@va.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - S56 EP - S65 PB - Elsevier Science, New York NY VL - 39 SN - 0749-3797, 0749-3797 KW - Prescriptions KW - Abstinence KW - American Indian people KW - Smoking KW - Cessation KW - Nicotine replacement therapy KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839570807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Smoking-Cessation+Strategies+for+American+Indians%3A+Should+Smoking-Cessation+Treatment+Include+a+Prescription+for+a+Complete+Home+Smoking+Ban%3F&rft.au=Fu%2C+Steven+S%3BBurgess%2C+Diana+J%3Bvan+Ryn%2C+Michele%3BRhodes%2C+Kris%3BWidome%2C+Rachel%3BRicards%2C+Jennifer+J%3BNoorbaloochi%2C+Siamak%3BClothier%2C+Barbara%3BSu%2C+Jennifer%3BJoseph%2C+Anne+M&rft.aulast=Fu&rft.aufirst=Steven&rft.date=2010-12-01&rft.volume=39&rft.issue=&rft.spage=S56&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.08.012 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Smoking; Nicotine replacement therapy; Cessation; American Indian people; Abstinence; Prescriptions DO - http://dx.doi.org/10.1016/j.amepre.2010.08.012 ER - TY - JOUR T1 - Augmenting maintenance of sinus rhythm in the control of atrial fibrillation by antiarrhythmic drug combinations. AN - 815549942; 21098417 AB - In recent years, a major development in the treatment of atrial fibrillation (AF) is the use of catheter ablation, and a significant number of patients may benefit from this mode of therapy. On a global scale, it may not be feasible to deal with most patients solely on the basis of ablation. Therefore, it is likely that much of the therapy for AF will continue to rely on antiarrhythmic agents for maintaining sinus rhythm. For many years, amiodarone and sotalol have been the dominant antiarrhythmic agents, with amiodarone being the most effective antiarrhythmic in suppressing AF; however, amiodarone use is limited due to concerns of end-organ toxicity. Upstream therapies, such as statins, fish oil, angiotensin converting enzyme (ACE) inhibitors, and angiotensin receptor blockers may also provide additive efficacy to these and other membrane-active antiarrhythmics. In recent years, a number of new agents are being developed and the first successful congener of amiodarone, dronedarone, has been shown to be effective in controlling AF and reducing cardiovascular hospitalization. This paper explores the possibility of augmenting the extent of controlling AF by combining multiple potent antiarrhythmic agents old and new. JF - Journal of cardiovascular pharmacology and therapeutics AU - Singh, Bramah N AD - Division of Cardiology, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA, USA. bsingh@ucla.edu Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 31S EP - 5S VL - 15 IS - 4 Suppl KW - Anti-Arrhythmia Agents KW - 0 KW - Sotalol KW - A6D97U294I KW - dronedarone KW - JQZ1L091Y2 KW - Amiodarone KW - N3RQ532IUT KW - Index Medicus KW - Drug Therapy, Combination KW - Sotalol -- therapeutic use KW - Humans KW - Catheter Ablation -- methods KW - Amiodarone -- analogs & derivatives KW - Atrial Fibrillation -- drug therapy KW - Amiodarone -- therapeutic use KW - Amiodarone -- adverse effects KW - Atrial Fibrillation -- physiopathology KW - Atrial Fibrillation -- surgery KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- therapeutic use KW - Anti-Arrhythmia Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815549942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.atitle=Augmenting+maintenance+of+sinus+rhythm+in+the+control+of+atrial+fibrillation+by+antiarrhythmic+drug+combinations.&rft.au=Singh%2C+Bramah+N&rft.aulast=Singh&rft.aufirst=Bramah&rft.date=2010-12-01&rft.volume=15&rft.issue=4+Suppl&rft.spage=31S&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.issn=1940-4034&rft_id=info:doi/10.1177%2F1074248410377617 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-28 N1 - Date created - 2010-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/1074248410377617 ER - TY - JOUR T1 - A new agent for atrial fibrillation: electrophysiological properties of dronedarone. AN - 815549875; 21098415 AB - Although originally synthesized as an antianginal compound, amiodarone has emerged as an effective antiarrhythmic for both supraventricular and ventricular arrhythmias. Over the decades, the properties, the effectiveness, the merits as well as the shortcomings of the compound have been well established. The major limitations of this agent are mainly due to the systemic side effects seen with prolonged therapy. Many of the toxic effects observed are primarily caused by the high iodine content present in the amiodarone molecule. Dronedarone, the first noniodinated amiodarone congener, has been developed largely to obtain the antiarrhythmic efficacy in the control of atrial fibrillation without the known adverse side effects of dronedarone. In this part of the supplement, the focus is the electrophysiological effects of dronedarone with the characterization in normal cardiac cells, in animal models of disease, as well as in human studies. JF - Journal of cardiovascular pharmacology and therapeutics AU - Singh, Bramah N AU - Cingolani, Eugenio AD - Division of Cardiology, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA, USA. bsingh@ucla.edu Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 6S EP - 14S VL - 15 IS - 4 Suppl KW - Anti-Arrhythmia Agents KW - 0 KW - dronedarone KW - JQZ1L091Y2 KW - Amiodarone KW - N3RQ532IUT KW - Index Medicus KW - Animals KW - Humans KW - Electrophysiologic Techniques, Cardiac -- methods KW - Disease Models, Animal KW - Amiodarone -- pharmacology KW - Amiodarone -- analogs & derivatives KW - Atrial Fibrillation -- drug therapy KW - Amiodarone -- therapeutic use KW - Amiodarone -- adverse effects KW - Atrial Fibrillation -- physiopathology KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- therapeutic use KW - Anti-Arrhythmia Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815549875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.atitle=A+new+agent+for+atrial+fibrillation%3A+electrophysiological+properties+of+dronedarone.&rft.au=Singh%2C+Bramah+N%3BCingolani%2C+Eugenio&rft.aulast=Singh&rft.aufirst=Bramah&rft.date=2010-12-01&rft.volume=15&rft.issue=4+Suppl&rft.spage=6S&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.issn=1940-4034&rft_id=info:doi/10.1177%2F1074248410377618 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-28 N1 - Date created - 2010-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/1074248410377618 ER - TY - JOUR T1 - A longitudinal investigation of the impact of life stress on HIV treatment adherence. AN - 762274635; 20577794 AB - Suboptimal antiretroviral adherence is associated with poorer HIV outcomes. Psychosocial factors, including life stress, depression and coping, may influence adherence behavior. This prospective investigation sought to examine the impact of life stress (acute life events, chronic stress, and perceived stress), depression, and coping style on adherence to HIV treatment regimes over time. Participants were 87 treatment-seeking HIV-infected individuals recruited from an urban HIV clinic. They completed clinician-administered interviews and self-report questionnaires at baseline and 3-month follow-up. Acute life events and chronic stress prospectively predicted decreases in treatment adherence more strongly among individuals in a major depressive episode (n = 21) compared to non-depressed individuals (n = 66). Coping style did not appear to be the mechanism by which life stress influenced adherence among depressed HIV-infected individuals. These findings demonstrate that life stress has toxic effects for depressed individuals and suggest that treatment adherence interventions with depressed individuals could be enhanced via development of stress management skills. JF - Journal of behavioral medicine AU - Bottonari, Kathryn A AU - Safren, Steven A AU - McQuaid, John R AU - Hsiao, Chiu-Bin AU - Roberts, John E AD - University at Buffalo: State University of New York, Buffalo, NY, USA. Kathryn.Bottonari@va.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 486 EP - 495 VL - 33 IS - 6 KW - Index Medicus KW - Humans KW - Depression -- psychology KW - Adult KW - Surveys and Questionnaires KW - Longitudinal Studies KW - Depression -- virology KW - Male KW - Female KW - Stress, Psychological -- virology KW - HIV Seropositivity -- psychology KW - HIV Infections -- virology KW - Adaptation, Psychological KW - HIV Infections -- drug therapy KW - HIV Infections -- psychology KW - Medication Adherence -- psychology KW - HIV Seropositivity -- virology KW - HIV Seropositivity -- drug therapy KW - Stress, Psychological -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762274635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+behavioral+medicine&rft.atitle=A+longitudinal+investigation+of+the+impact+of+life+stress+on+HIV+treatment+adherence.&rft.au=Bottonari%2C+Kathryn+A%3BSafren%2C+Steven+A%3BMcQuaid%2C+John+R%3BHsiao%2C+Chiu-Bin%3BRoberts%2C+John+E&rft.aulast=Bottonari&rft.aufirst=Kathryn&rft.date=2010-12-01&rft.volume=33&rft.issue=6&rft.spage=486&rft.isbn=&rft.btitle=&rft.title=Journal+of+behavioral+medicine&rft.issn=1573-3521&rft_id=info:doi/10.1007%2Fs10865-010-9273-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-11 N1 - Date created - 2010-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Health Psychol. 2000 Mar;19(2):124-33 [10762096] Behav Res Ther. 2007 Jan;45(1):179-88 [16488389] J Abnorm Psychol. 2000 Nov;109(4):787-91 [11196005] AIDS Care. 2000 Oct;12(5):663-72 [11218551] Am J Psychiatry. 2001 May;158(5):725-30 [11329393] Behav Res Ther. 2001 Oct;39(10):1151-62 [11579986] Women Health. 2002;36(1):97-111 [12215006] Psychosomatics. 2002 Nov-Dec;43(6):478-85 [12444231] Aust N Z J Psychiatry. 2003 Feb;37(1):70-7 [12534660] J Acquir Immune Defic Syndr. 2002 Dec 15;31 Suppl 3:S163-6 [12562043] AIDS Patient Care STDS. 2003 Aug;17(8):407-16 [13678542] Annu Rev Psychol. 2004;55:745-74 [14744233] J Acquir Immune Defic Syndr. 2006 Dec 1;43 Suppl 1:S23-35 [17133201] J Nerv Ment Dis. 2007 Jan;195(1):10-9 [17220734] AIDS. 2007 May 31;21(9):1175-83 [17502728] AIDS Behav. 2008 Jan;12(1):86-94 [17577653] Health Psychol. 2008 Jan;27(1):4-14 [18230008] AIDS Patient Care STDS. 2008 May;22(5):403-11 [18373416] Curr HIV/AIDS Rep. 2008 Nov;5(4):163-71 [18838056] Health Psychol. 2009 Jan;28(1):1-10 [19210012] Assessment. 2009 Jun;16(2):127-44 [19234296] Health Psychol. 2004 Jul;23(4):413-8 [15264978] Psychosomatics. 2004 Sep-Oct;45(5):394-402 [15345784] Br J Psychiatry. 1979 Apr;134:382-9 [444788] J Health Soc Behav. 1983 Dec;24(4):385-96 [6668417] J Pers Soc Psychol. 1986 Dec;51(6):1173-82 [3806354] J Abnorm Psychol. 1987 Aug;96(3):190-8 [3680756] Fam Med. 1993 Jun;25(6):391-5 [8349060] J Consult Clin Psychol. 1994 Jun;62(3):550-9 [8063981] Psychol Bull. 1994 Jul;116(1):29-45 [8078972] J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57 [9881538] AIDS Patient Care STDS. 2004 Oct;18(10):594-603 [15630787] AIDS Patient Care STDS. 2004 Nov;18(11):644-57 [15633262] J Antimicrob Chemother. 2005 Apr;55(4):413-6 [15722389] J Acquir Immune Defic Syndr. 2005 Apr 15;38(5):590-7 [15793371] Health Psychol. 2005 Jul;24(4):385-92 [16045374] AIDS Patient Care STDS. 2005 Nov;19(11):719-27 [16283832] AIDS Behav. 2006 May;10(3):227-45 [16783535] AIDS Care. 2000 Jun;12(3):255-66 [10928201] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10865-010-9273-9 ER - TY - JOUR T1 - Destiny Is Now AN - 860388341; 14539864 AB - Dr Guccione has served as Senior Vice President, Division of Practice and Research, for the American Physical Therapy Association. He was Director of Physical Therapy Services for Massachusetts General Hospital and spent 11 years with the Boston University Multipurpose Arthritis Center as part of the Health Services Research Unit. His research interests are in geriatrics, health status measurement, and functional outcomes after rehabilitation. In addition to authoring or co-authoring more than 20 articles in peer-reviewed journals, he has received grant funding from the Arthritis Foundation and was the recipient of a Special Emphasis Research Career Award from the National Institute on Aging. His clinical practice has centered mainly on geriatrics and musculoskeletal impairment in older adults. He is the editor of a textbook on geriatric physical therapy, now preparing its third edition. JF - Physical Therapy AU - Guccione, A A Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1678 EP - 1690 VL - 90 IS - 11 SN - 0031-9023, 0031-9023 KW - Physical Education Index KW - Measurement KW - Honors KW - Rehabilitation KW - APTA KW - Physical therapy KW - Health (services) KW - Arthritis KW - Geriatrics KW - Hospitals KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860388341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+Therapy&rft.atitle=Destiny+Is+Now&rft.au=Guccione%2C+A+A&rft.aulast=Guccione&rft.aufirst=A&rft.date=2010-11-01&rft.volume=90&rft.issue=11&rft.spage=1678&rft.isbn=&rft.btitle=&rft.title=Physical+Therapy&rft.issn=00319023&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2011-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Measurement; Honors; APTA; Rehabilitation; Health (services); Physical therapy; Arthritis; Geriatrics; Hospitals ER - TY - JOUR T1 - Incarceration as a Risk Factor for Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Co-infection in Mississippi AN - 839585229; 201100533 AB - Background. Injection drug use (IDU) is the most commonly recognized risk factor for co-infection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). We examined risks for HIV/HCV co-infection in a population with a low rate of IDU. Methods. A sample of 32 HIV/HCV co-infected patients and 79 HIV-infected patients were enrolled from two clinics in Mississippi. Patients completed an audio computer-assisted self-interview (ACASI) assessing risks for infection with both viruses. Results. In a multivariable logistic regression model, greater age (p=.01), alcohol use (p=.02), history of incarceration (p=.04), and blood transfusion prior to 1992 (p=.03) were independently associated with HIV/HCV co-infection. Conclusions. Incarceration was significantly associated with HIV-HCV co-infection in our sample. Further examination is warranted to develop policies for HCV prevention and treatment within the prison system. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Burton, Mary Jane AU - Reilly, Kathleen H AU - Penman, Alan AD - Medical Service (111), 1500 E. Woodrow Wilson Avenue, Jackson, MS 39216; (601) 364-1251 mary.burton2@va.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 1194 EP - 1202 PB - John Hopkins University Press, Baltimore MD VL - 21 IS - 4 SN - 1049-2089, 1049-2089 KW - Human immunodeficiency virus infection, hepatitis C virus infection, injection drug use, incarceration KW - Imprisonment KW - Prisons KW - Risk factors KW - Hepatitis C KW - HIV KW - Intravenous drug addicts KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839585229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Incarceration+as+a+Risk+Factor+for+Hepatitis+C+Virus+%28HCV%29+and+Human+Immunodeficiency+Virus+%28HIV%29+Co-infection+in+Mississippi&rft.au=Burton%2C+Mary+Jane%3BReilly%2C+Kathleen+H%3BPenman%2C+Alan&rft.aulast=Burton&rft.aufirst=Mary&rft.date=2010-11-01&rft.volume=21&rft.issue=4&rft.spage=1194&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Hepatitis C; HIV; Imprisonment; Risk factors; Intravenous drug addicts; Prisons ER - TY - JOUR T1 - Let's Get Certified: An Innovative National Campaign AN - 839579867; 201103788 AB - During Nurses Week 2008, the Department of Veterans Affairs (VA) Office of Nursing Services (ONS) launched an innovative campaign to increase specialty certification for its nursing workforce that resulted in a one-of-a-kind national initiative. The initiative 'Let's Get Certified,' currently in its third year of implementation with Phase III of the campaign, has raised the awareness of the benefits of specialty certification among the VA nursing staff. This movement has yielded a more highly educated and competent workforce, improved nurse satisfaction, and promoted quality healthcare to veterans. In early 2008 the idea for the campaign was presented to the ONS Director of Workforce Development and resulted in a nursing work group representing the 45,000 VA nurses throughout the country who provided valuable input into the development of the initial campaign. [Copyright Elsevier B.V.] JF - Nurse Leader AU - Seaman, Mary AU - Bernstein, Alan Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 31 EP - 36 PB - Elsevier Ltd, The Netherlands VL - 8 IS - 6 SN - 1541-4612, 1541-4612 KW - Veterans KW - Campaigns KW - Nursing KW - Labour force KW - Certification KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839579867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nurse+Leader&rft.atitle=Let%27s+Get+Certified%3A+An+Innovative+National+Campaign&rft.au=Seaman%2C+Mary%3BBernstein%2C+Alan&rft.aulast=Seaman&rft.aufirst=Mary&rft.date=2010-11-01&rft.volume=8&rft.issue=6&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Nurse+Leader&rft.issn=15414612&rft_id=info:doi/10.1016%2Fj.mnl.2010.09.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Campaigns; Nursing; Veterans; Certification; Labour force DO - http://dx.doi.org/10.1016/j.mnl.2010.09.001 ER - TY - JOUR T1 - Nursing Staff, Patient, and Environmental Factors Associated with Accurate Pain Assessment AN - 839578819; 201103869 AB - Context. Although pain ranks highly among reasons for seeking care, routine pain assessment is often inaccurate. Objectives: This study evaluated factors associated with nurses (e.g., registered) and other nursing support staff (e.g., licensed vocational nurses and health technicians) discordance with patients in estimates of pain in a health system where routine pain screening using a 0-10 numeric rating scale (NRS) is mandated. Methods. This was a cross-sectional, visit-based, cohort study that included surveys of clinic outpatients (n=465) and nursing staff (n=94) who screened for pain as part of routine vital sign measurement during intake. These data were supplemented by chart review. We compared patient pain levels documented by the nursing staff (N-NRS) with those reported by the patient during the study survey (S-NRS). Results: Pain underestimation (N-NRSS-NRS) in 7% of the cases. Nursing staff used informal pain-screening techniques that did not follow established NRS protocols in half of the encounters. Pain underestimation was positively associated with more years of nursing staff work experience and patient anxiety or post-traumatic stress disorder and negatively associated with better patient-reported health status. Pain overestimation was positively associated with nursing staff's use of the full NRS protocol and with a distracting environment in which patient vitals were taken. Conclusion. Despite a long-standing mandate, pain-screening implementation falls short, and informal screening is common. [Copyright U.S. Cancer Pain Relief Committee. Published by Elsevier Inc.] JF - Journal of Pain and Symptom Management AU - Shugarman, Lisa R AU - Goebel, Joy R AU - Lanto, Andy AU - Asch, Steven M AU - Sherbourne, Cathy D AU - Lee, Martin L AU - Rubenstein, Lisa V AU - Wen, Li AU - Meredith, Lisa AU - Lorenz, Karl A AD - c/o Lorenz -- Veterans Administration Greater Los Angeles Healthcare System, CA Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 723 EP - 733 PB - Elsevier, New York NY VL - 40 IS - 5 SN - 0885-3924, 0885-3924 KW - Words: Pain measurement, veterans, outpatients KW - Assessment KW - Screening KW - Nursing KW - Nurses KW - Cohort analysis KW - Pain KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839578819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pain+and+Symptom+Management&rft.atitle=Nursing+Staff%2C+Patient%2C+and+Environmental+Factors+Associated+with+Accurate+Pain+Assessment&rft.au=Shugarman%2C+Lisa+R%3BGoebel%2C+Joy+R%3BLanto%2C+Andy%3BAsch%2C+Steven+M%3BSherbourne%2C+Cathy+D%3BLee%2C+Martin+L%3BRubenstein%2C+Lisa+V%3BWen%2C+Li%3BMeredith%2C+Lisa%3BLorenz%2C+Karl+A&rft.aulast=Shugarman&rft.aufirst=Lisa&rft.date=2010-11-01&rft.volume=40&rft.issue=5&rft.spage=723&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pain+and+Symptom+Management&rft.issn=08853924&rft_id=info:doi/10.1016%2Fj.jpainsymman.2010.02.024 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JSPME2 N1 - SubjectsTermNotLitGenreText - Pain; Nursing; Nurses; Screening; Assessment; Cohort analysis DO - http://dx.doi.org/10.1016/j.jpainsymman.2010.02.024 ER - TY - JOUR T1 - Improving Patient Outcomes by Developing Nurse Champions AN - 839577078; 201103304 AB - To adequately describe the role of a nurse leader in developing staff and the unique Tampa VA Polytrauma Transitional Rehabilitation Program, a description of the Polytrauma System of Care (PSC) is warranted. This description will subsequently support the development of the unique and distinct role of the transitional nurse champion. The intimate level of involvement of a nurse leader from the inception of this program and an understanding of the exclusive needs of this patient population were imperative to program development and success. The following is a brief description of this process. [Copyright Elsevier B.V.] JF - Nurse Leader AU - Perla, Lisa Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 26 EP - 28, 54 PB - Elsevier Ltd, The Netherlands VL - 8 IS - 6 SN - 1541-4612, 1541-4612 KW - Clinical outcomes KW - Rehabilitation KW - Leaders KW - Work roles KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839577078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nurse+Leader&rft.atitle=Improving+Patient+Outcomes+by+Developing+Nurse+Champions&rft.au=Perla%2C+Lisa&rft.aulast=Perla&rft.aufirst=Lisa&rft.date=2010-11-01&rft.volume=8&rft.issue=6&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Nurse+Leader&rft.issn=15414612&rft_id=info:doi/10.1016%2Fj.mnl.2010.09.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Leaders; Work roles; Rehabilitation; Clinical outcomes DO - http://dx.doi.org/10.1016/j.mnl.2010.09.002 ER - TY - JOUR T1 - Heroin anticraving medications: A systematic review AN - 835114112; 201100249 AB - Background: Heroin craving is a trigger for relapse and dropping out of treatment. Methadone has been the standard medication for the management of heroin craving. Objectives: We explored the medication options other than methadone which may have heroin anticraving properties. Methods: To be selected for the review, articles had to include outcome measures of the effect of the studied medication on subjective and/or objective opiate craving and be of the following two types: (1) randomized, controlled, and/or double-blind clinical trials (RCTs) examining the relationship between the studied medication and heroin craving; (2) nonrandomized and observational studies (NRSs) examining the relationship between the studied medication and heroin craving. Thirty-three articles were initially included in the review. Twenty-one were excluded because they did not meet the inclusion criteria. We present the results of 12 articles that met all the inclusion criteria. Results: Some new medications have been under investigation and seem promising for the treatment of opiate craving. Buprenorphine is the second most studied medication after methadone for its effect on opiate craving. At doses above 8 mg daily, it seems very promising and practical for managing opiate craving in patients receiving long-term opioid maintenance treatment. Conclusions and Scientific Significance: In doses higher than 8 mg daily, buprenorphine is an appropriate treatment for opiate craving. More research with rigorous methodology is needed to study the effect of buprenorphine on heroin craving. Also more studies are needed to directly compare buprenorphine and methadone with regard to their effects on heroin craving. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Fareed, Ayman AU - Vayalapalli, Sreedevi AU - Casarella, Jennifer AU - Amar, Richard AU - Drexler, Karen AD - Department of Psychiatry, Emory University, School of Medicine/Atlanta VA Medical center, Atlanta VA Medical Center 116A, 1670 Clairmont Rd., Decatur, GA 30033, USA ayman.fareed@va.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 332 EP - 341 PB - Taylor & Francis Inc., Philadelphia, PA VL - 36 IS - 6 SN - 0095-2990, 0095-2990 KW - heroin anticraving medications KW - Heroin KW - Alternative Approaches KW - Methadone Maintenance KW - Drug Abuse KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/835114112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Heroin+anticraving+medications%3A+A+systematic+review&rft.au=Fareed%2C+Ayman%3BVayalapalli%2C+Sreedevi%3BCasarella%2C+Jennifer%3BAmar%2C+Richard%3BDrexler%2C+Karen&rft.aulast=Fareed&rft.aufirst=Ayman&rft.date=2010-11-01&rft.volume=36&rft.issue=6&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.3109%2F00952990.2010.505991 LA - English DB - Social Services Abstracts N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-28 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Heroin; Drug Abuse; Alternative Approaches; Methadone Maintenance DO - http://dx.doi.org/10.3109/00952990.2010.505991 ER - TY - JOUR T1 - Assessing methicillin-resistant Staphylococcus aureus knowledge among nursing students AN - 822497467; 201031907 AB - MRSA is becoming more prevalent in healthcare settings and community settings. The purpose of the study is to assess MRSA knowledge among nursing students. A MRSA Survey was administered to nursing students to gauge their general knowledge about MRSA. The scores from the MRSA Survey indicated that nursing students had a knowledge deficit regarding MRSA. Nursing student's need specific MRSA content in the nursing curriculum and need role models in healthcare settings who are following infection control guidelines. A variety of teaching strategies may be used to effectively teach this topic to nursing students. The goal of this education is to prevent the spread of MRSA organisms and decrease the related costs of treating MRSA infections. [Copyright Elsevier Ltd.] JF - Nurse Education Today AU - Jennings-Sanders, Andrea AU - Jury, Lucy AD - Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA andrea.jennings-sanders@va.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 789 EP - 793 PB - Elsevier Ltd, Amsterdam The Netherlands VL - 30 IS - 8 SN - 0260-6917, 0260-6917 KW - MRSA Infection control Nursing curriculum KW - Professional knowledge KW - Health care KW - MRSA KW - Disease management KW - Nursing KW - Staphylococcus aureus KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822497467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nurse+Education+Today&rft.atitle=Assessing+methicillin-resistant+Staphylococcus+aureus+knowledge+among+nursing+students&rft.au=Jennings-Sanders%2C+Andrea%3BJury%2C+Lucy&rft.aulast=Jennings-Sanders&rft.aufirst=Andrea&rft.date=2010-11-01&rft.volume=30&rft.issue=8&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Nurse+Education+Today&rft.issn=02606917&rft_id=info:doi/10.1016%2Fj.nedt.2010.02.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - MRSA; Nursing; Professional knowledge; Health care; Staphylococcus aureus; Disease management DO - http://dx.doi.org/10.1016/j.nedt.2010.02.001 ER - TY - JOUR T1 - The influence of organizational context on quality improvement and patient safety efforts in infection prevention: a multi-center qualitative study AN - 816378451; 4136951 AB - Patient safety is a healthcare priority worldwide, with most hospitals engaging in activities to improve care quality, safety and outcomes. Despite these efforts, we have limited understanding of why quality improvement efforts are successful in some hospitals and not others. Using data collected as part of a multi-center study, we closely examined quality improvement efforts and the implementation of recommended practices to prevent central line-associated bloodstream infections (CLABSI) in US hospitals. We compare and contrast the experiences among hospitals to better understand 'how' and 'why' certain hospitals were more successful with practice implementation when taking into consideration specific aspects of the organizational context. This study reveals that among a number of hospitals that focused on implementing practices to prevent CLABSI, the experience and outcomes varied considerably despite using similar implementation strategies. Moreover, our findings provide important insights about how and why different quality improvement strategies might perform across organizations with differing contextual characteristics. All rights reserved, Elsevier JF - Social science and medicine AU - Krein, Sarah L AU - Damschroder, L J AU - Kowalski, C P AU - Forman, J AU - Hofer, T P AU - Saint, S AD - Veterans' Administration Ann Arbor Healthcare System Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1692 EP - 1701 VL - 71 IS - 9 SN - 0277-9536, 0277-9536 KW - Sociology KW - Qualitative analysis KW - Quality of service KW - Safety KW - Patients KW - Diseases KW - U.S.A. KW - Hospitals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/816378451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+science+and+medicine&rft.atitle=The+influence+of+organizational+context+on+quality+improvement+and+patient+safety+efforts+in+infection+prevention%3A+a+multi-center+qualitative+study&rft.au=Krein%2C+Sarah+L%3BDamschroder%2C+L+J%3BKowalski%2C+C+P%3BForman%2C+J%3BHofer%2C+T+P%3BSaint%2C+S&rft.aulast=Krein&rft.aufirst=Sarah&rft.date=2010-11-01&rft.volume=71&rft.issue=9&rft.spage=1692&rft.isbn=&rft.btitle=&rft.title=Social+science+and+medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2010.07.041 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6013 6590; 10519 3279 971 3286; 10526; 9271 7890 5792 10484; 11229; 3617 6220; 433 293 14 DO - http://dx.doi.org/10.1016/j.socscimed.2010.07.041 ER - TY - JOUR T1 - Does PTSD moderate the relationship between social support and suicide risk in Iraq and Afghanistan War Veterans seeking mental health treatment? AN - 1017970010; 16706521 AB - Objective: This study examined posttraumatic stress disorder (PTSD) as a potential moderating variable in the relationship between social support and elevated suicide risk in a sample of treatment-seeking Iraq and Afghanistan War Veterans. Method: As part of routine care, self-reported marital status, satisfaction with social networks, PTSD, and recent suicidality were assessed in Veterans (N=431) referred for mental health services at a large Veteran Affairs Medical Center. Logistic regression analyses were conducted using this cross-sectional data sample to test predictions of diminished influence of social support on suicide risk in Veterans reporting PTSD. Results: Thirteen percent of Veterans were classified as being at elevated risk for suicide. Married Veterans were less likely to be at elevated suicide risk relative to unmarried Veterans and Veterans reporting greater satisfaction with their social networks were less likely to be at elevated risk relative to Veterans reporting lower satisfaction. Satisfaction with social networks was protective for suicide risk in PTSD and non-PTSD cases, but was significantly less protective for veterans reporting PTSD. Conclusions: Veterans who are married and Veterans who report greater satisfaction with social networks are less likely to endorse suicidal thoughts or behaviors suggestive of elevated suicide risk. However, the presence of PTSD may diminish the protective influence of social networks among treatment-seeking Veterans. Depression and Anxiety, 2010. Published 2010 Wiley-Liss, Inc. JF - Depression and Anxiety (Hoboken) AU - Jakupcak, Matthew AU - Vannoy, Steven AU - Imel, Zac AU - Cook, Jessica W AU - Fontana, Alan AU - Rosenheck, Robert AU - McFall, Miles AD - VISN 20 Northwest Mental Illness Research, Education, and Clinical Center, Seattle, Washington, matthew.jakupcak@va.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1001 EP - 1005 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 27 IS - 11 SN - 1520-6394, 1520-6394 KW - Health & Safety Science Abstracts; Risk Abstracts; CSA Neurosciences Abstracts KW - Anxiety KW - Depression KW - Marriage KW - Mental disorders KW - Military personnel KW - Post-traumatic stress disorder KW - Posttraumatic stress disorder KW - Prediction KW - Psychology KW - Regression analysis KW - Risk assessment KW - Social interactions KW - Suicide KW - War KW - depression KW - marriage KW - mental disorders KW - posttraumatic stress disorder KW - suicide KW - war KW - Afghanistan KW - Iraq KW - N3 11001:Behavioral and Cognitive Neuroscience KW - H 0500:General KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017970010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+Anxiety+%28Hoboken%29&rft.atitle=Does+PTSD+moderate+the+relationship+between+social+support+and+suicide+risk+in+Iraq+and+Afghanistan+War+Veterans+seeking+mental+health+treatment%3F&rft.au=Jakupcak%2C+Matthew%3BVannoy%2C+Steven%3BImel%2C+Zac%3BCook%2C+Jessica+W%3BFontana%2C+Alan%3BRosenheck%2C+Robert%3BMcFall%2C+Miles&rft.aulast=Jakupcak&rft.aufirst=Matthew&rft.date=2010-11-01&rft.volume=27&rft.issue=11&rft.spage=1001&rft.isbn=&rft.btitle=&rft.title=Depression+and+Anxiety+%28Hoboken%29&rft.issn=15206394&rft_id=info:doi/10.1002%2Fda.20722 L2 - http://onlinelibrary.wiley.com/doi/10.1002/da.20722/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mental disorders; Depression; Anxiety; Regression analysis; Suicide; Post-traumatic stress disorder; Military personnel; Social interactions; Prediction; posttraumatic stress disorder; Psychology; Marriage; marriage; depression; war; Posttraumatic stress disorder; War; mental disorders; suicide; Afghanistan; Iraq DO - http://dx.doi.org/10.1002/da.20722 ER - TY - JOUR T1 - Tricyclic Antidepressants and Headaches: Systematic Review and Meta-Analysis AN - 822497600; 201031890 AB - STUDY QUESTION: Compared with selective serotonin reuptake inhibitors, how effective are tricyclic antidepressants in treating migraine, tension-type, and mixed headaches and what are the adverse effects? SUMMARY ANSWER: Tricyclics are effective in preventing migraine and tension-type headaches and are more effective than selective serotonin reuptake inhibitors, although with more adverse effects. The effectiveness of tricyctics seems to increase over time. WHAT IS KNOWN AND WHAT THIS PAPER ADDS: Tricyclics are effective in treating tension-type and migraine headaches. This study showed that tricyclics are more effective than selective serotonin reuptake inhibitors for both tension-type and migraine headaches and are more effective overtime. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Jackson, Jeffrey L AU - Shimeall, William AU - Sessums, Laura AU - DeZee, Kent J AU - Becher, Dorothy AU - Diemer, Margretta AU - Berbano, Elizabeth AU - O'Malley, Patrick G AD - General Medicine Division, Walter Reed Army Medical Center, Washington, DC Jeffrey.jackson6@va.gov Y1 - 2010/10/23/ PY - 2010 DA - 2010 Oct 23 SP - 869 PB - British Medical Association, BMJ Publishing Group, London UK VL - 341 IS - 7778 SN - 0959-535X, 0959-535X KW - Attention deficit disorder KW - Migraine KW - Headaches KW - Antidepressant drugs KW - Serotonin reuptake inhibitors KW - Side effects KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822497600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Tricyclic+Antidepressants+and+Headaches%3A+Systematic+Review+and+Meta-Analysis&rft.au=Jackson%2C+Jeffrey+L%3BShimeall%2C+William%3BSessums%2C+Laura%3BDeZee%2C+Kent+J%3BBecher%2C+Dorothy%3BDiemer%2C+Margretta%3BBerbano%2C+Elizabeth%3BO%27Malley%2C+Patrick+G&rft.aulast=Jackson&rft.aufirst=Jeffrey&rft.date=2010-10-23&rft.volume=341&rft.issue=7778&rft.spage=869&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.c5222 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Migraine; Serotonin reuptake inhibitors; Side effects; Antidepressant drugs; Headaches; Attention deficit disorder DO - http://dx.doi.org/10.1136/bmj.c5222 ER - TY - JOUR T1 - Debate: CON Position. People with Chronic Kidney Disease Should Have a Blood Pressure Lower than 130/80 mm Hg AN - 867744448; 13877417 AB - No abstract available Copyright [copy 2010 S. Karger AG, Basel JF - American Journal of Nephrology AU - Agarwal, Rajiv AD - Indiana University School of Medicine and Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, Ind., USA Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 374 EP - 376 PB - S. Karger AG, P.O. Box Basel CH-4009 Switzerland VL - 32 IS - 4 SN - 0250-8095, 0250-8095 KW - Toxicology Abstracts KW - Kidney diseases KW - Blood pressure KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867744448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Nephrology&rft.atitle=Debate%3A+CON+Position.+People+with+Chronic+Kidney+Disease+Should+Have+a+Blood+Pressure+Lower+than+130%2F80+mm+Hg&rft.au=Agarwal%2C+Rajiv&rft.aulast=Agarwal&rft.aufirst=Rajiv&rft.date=2010-10-01&rft.volume=32&rft.issue=4&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Nephrology&rft.issn=02508095&rft_id=info:doi/10.1159%2F000319637 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Kidney diseases; Blood pressure DO - http://dx.doi.org/10.1159/000319637 ER - TY - JOUR T1 - Role of the family in suicide prevention: An attachment and family systems perspective AN - 855899965; 201108049 AB - Suicide can be an act of despair, anger, or escape from intolerable pain associated with prior bonding disturbances within the family system, interpersonal loss, and current perceived lack of social support. Using a variety of online databases, the authors examined the research on the family's role in preventing suicide from an attachment and family systems perspective. They found relevant articles describing how to make use of family support in suicide prevention. From a study of the literature, the authors outline three new family concepts in suicide prevention: family cohesion, family adhesion, and formation of a new family. Therapists should use every familial resource to avoid premature closure and to expand perception of support options. The authors suggest specific practice recommendations to successfully involve families in suicide prevention based on the outlined family conceptual framework, and they recommend research investigation to determine empirical validation of these tentative formulations. Adapted from the source document. JF - Bulletin of the Menninger Clinic AU - Prabhu, Sheila Lobo AU - Molinari, Victor AU - Bowers, Theron AU - Lomax, James AD - Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine, 6655 Travis, Houston, Texas 77030 SheilaM.Loboprabhu@med.va.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 301 EP - 327 PB - Guilford Publications, New York NY VL - 74 IS - 4 SN - 0025-9284, 0025-9284 KW - Family support KW - Attachment KW - Online databases KW - Suicide KW - Family system perspective KW - Preventive programmes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855899965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+the+Menninger+Clinic&rft.atitle=Role+of+the+family+in+suicide+prevention%3A+An+attachment+and+family+systems+perspective&rft.au=Prabhu%2C+Sheila+Lobo%3BMolinari%2C+Victor%3BBowers%2C+Theron%3BLomax%2C+James&rft.aulast=Prabhu&rft.aufirst=Sheila&rft.date=2010-10-01&rft.volume=74&rft.issue=4&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+the+Menninger+Clinic&rft.issn=00259284&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-03-07 N1 - Last updated - 2016-09-27 N1 - CODEN - BMCLA4 N1 - SubjectsTermNotLitGenreText - Preventive programmes; Family system perspective; Suicide; Attachment; Online databases; Family support ER - TY - JOUR T1 - Viable Fibroblast Matrix Patch Induces Angiogenesis and Increases Myocardial Blood Flow in Heart Failure After Myocardial Infarction AN - 839699227; 14092018 AB - Background: This study examines a viable biodegradable three-dimensional fibroblast construct (3DFC) in a model of chronic heart failure. The viable fibroblasts, cultured on a vicryl mesh, secrete growth factors that stimulate angiogenesis. Methods: We ligated the left coronary artery of male Sprague-Dawley rats, implanted the 3DFC 3 weeks after myocardial infarction and obtained end point data 3 weeks later, that is, 6 weeks after myocardial infarction. Results: Implanting the 3DFC increases (p<0.05) myocardial blood flow twofold, microvessel formation (0.02 plus or minus 0.01 vs. 0.07 plus or minus 0.03 vessels/ mu m super(2)), and ventricular wall thickness (0.53 plus or minus 0.02 to 1.02 plus or minus 0.17 mm). The 3DFC shifts the passive pressure volume loop toward the pressure axis but does not alter left ventricular (LV) ejection fraction, systolic displacement, LV end-diastolic pressure/dimension, or LV cavity area. The 3DFC stimulates selected cytokine activation with a decrease in the proinflammatory cascade and increased total protein content stimulated by strained 3DFC in vitro. Conclusion: The 3DFC functions as a cell delivery device providing matrix support for resident cell survival and integration into the heart. The imbedded fibroblasts of the 3DFC release a complex blend of cardioactive cytokines promoting increases in microvessel density and anterior wall blood flow but does not improve ejection fraction or alter LV remodeling. JF - Tissue Engineering, Part A: Tissue Engineering AU - Lancaster, J AU - Juneman, E AU - Hagerty, T AU - Do, R AU - Hicks, M AU - Meltzer, K AU - Standley, P AU - Gaballa, M AU - Kellar, R AU - Goldman, S AU - Thai, H AD - 3601 S. 6th Ave, Southern Arizona VA Health Care System, Cardiology 1-111C, Tucson, AZ 85723, USA, Jordan.Lancaster@VA.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 3065 EP - 3073 VL - 16 IS - 10 SN - 1937-3341, 1937-3341 KW - Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Heart KW - Cavities KW - Data processing KW - Angiogenesis KW - Tissue engineering KW - Biodegradability KW - Myocardial infarction KW - Inflammation KW - Fibroblasts KW - coronary artery KW - Integration KW - Ventricle KW - Cytokines KW - Growth factors KW - Pressure KW - Heart diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839699227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.atitle=Viable+Fibroblast+Matrix+Patch+Induces+Angiogenesis+and+Increases+Myocardial+Blood+Flow+in+Heart+Failure+After+Myocardial+Infarction&rft.au=Lancaster%2C+J%3BJuneman%2C+E%3BHagerty%2C+T%3BDo%2C+R%3BHicks%2C+M%3BMeltzer%2C+K%3BStandley%2C+P%3BGaballa%2C+M%3BKellar%2C+R%3BGoldman%2C+S%3BThai%2C+H&rft.aulast=Lancaster&rft.aufirst=J&rft.date=2010-10-01&rft.volume=16&rft.issue=10&rft.spage=3065&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ften.tea.2009.0589 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Heart; Cell survival; Cavities; Data processing; Angiogenesis; Tissue engineering; Biodegradability; Myocardial infarction; coronary artery; Fibroblasts; Inflammation; Integration; Ventricle; Cytokines; Growth factors; Pressure; Heart diseases DO - http://dx.doi.org/10.1089/ten.tea.2009.0589 ER - TY - JOUR T1 - Normative Data for the Words-in-Noise Test for 6- to 12-Year-Old Children AN - 822513015; 201022614 AB - Purpose: To establish normative data for children on the Words-in-Noise Test (WIN; R. H. Wilson, 2003; R. H. Wilson & R. McArdle, 2007). Method: Forty-two children in each of 7 age groups, ranging in age from 6 to 12 years (n = 294), and 24 young adults (age range: 18-27 years) with normal hearing for pure tones participated. All listeners were screened at 15 dB HL (American National Standards Institute, 2004) with the octave interval between 500 and 4000 Hz. Randomizations of WIN Lists 1, 2, and 1 or WIN Lists 2, 1, and 2 were presented with the noise fixed at 70 dB SPL, followed by presentation at 90 dB SPL of the 70 Northwestern University Auditory Test No. 6 (T. W. Tillman & R. Carhart, 1966) words used in the WIN. Finally, the Peabody Picture Vocabulary Test-Revised (L. M. Dunn & L. M. Dunn, 1981) was administered. Testing was conducted in a quiet room. Results: There were 3 main findings: (a) The biggest change in recognition performance occurred between the ages of 6 and 7 years; (b) from 9 to 12 years, recognition performance was stable; and (c) performance by young adults (18-27 years) was slightly better (1-2 dB) than performance by the older children. Conclusion: The WIN can be used with children as young as 6 years of age; however, age-specific ranges of normal recognition performance must be used. Adapted from the source document JF - Journal of Speech, Language, and Hearing Research AU - Wilson, Richard H AU - Farmer, Nicole M AU - Gandhi, Avni AU - Shelburne, Emily AU - Weaver, Jamie AD - Audiology (126/151), VA Medical Center, Mountain Home, TN 37684 richard.wilson2@va.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 1111 EP - 1121 VL - 53 IS - 5 SN - 1092-4388, 1092-4388 KW - Vocabulary (94830) KW - Speech Perception (82700) KW - Recognition (71850) KW - Signal to Noise Ratio (78580) KW - Tone (90300) KW - Auditory Processing (05920) KW - Words (98400) KW - Children (11850) KW - article KW - 4017: psycholinguistics; psychoacoustics/speech perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822513015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=Normative+Data+for+the+Words-in-Noise+Test+for+6-+to+12-Year-Old+Children&rft.au=Wilson%2C+Richard+H%3BFarmer%2C+Nicole+M%3BGandhi%2C+Avni%3BShelburne%2C+Emily%3BWeaver%2C+Jamie&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2010-10-01&rft.volume=53&rft.issue=5&rft.spage=1111&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2010-12-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Signal to Noise Ratio (78580); Children (11850); Words (98400); Tone (90300); Auditory Processing (05920); Recognition (71850); Speech Perception (82700); Vocabulary (94830) ER - TY - JOUR T1 - How Does Tele-Mental Health Affect Group Therapy Process? Secondary Analysis of a Noninferiority Trial AN - 772252356; 201030060 AB - Objective: Video teleconferencing (VTC) is used for mental health treatment delivery to geographically remote, underserved populations. However, few studies have examined how VTC affects individual or group psychotherapy processes. This study compares process variables such as therapeutic alliance and attrition among participants receiving anger management group therapy either through traditional face-to-face delivery or by VTC. Method: The current study represents secondary analyses of a randomized noninferiority trial (Morland et al., in press) in which clinical effectiveness of VTC delivery proved noninferior to in-person delivery. Participants were male veterans (N = 112) with posttraumatic stress disorder (PTSD) and moderate to severe anger problems. The present study examined potential differences in process variables, including therapeutic alliance, satisfaction, treatment credibility, attendance, homework completion, and attrition. Results: No significant differences were found between the two modalities on most process variables. However, individuals in the VTC condition exhibited lower alliance with the group leader than those in the in-person condition. Mean self-leader alliance scores were 4.2 (SD = 0.8) and 4.5 (SD = 0.4), respectively, where 5 represents strongly agree and 4 represents agree with positive statements about the relationship, suggesting that participants in both conditions felt reasonably strong alliance in absolute terms. Individuals who had stronger alliance tended to have better anger outcomes, yet the effect was not strong enough to result in the VTC condition producing inferior aggregate outcomes. Conclusion: Our findings suggest that even if group psychotherapy via VTC differs in subtle ways from in-person delivery, VTC is a viable and effective means of delivering psychotherapy. [Copyright American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Greene, Carolyn J AU - Morland, Leslie A AU - MacDonald, Alexandra AU - Frueh, B Christopher AU - Grubbs, Kathleen M AU - Rosen, Craig S Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 746 EP - 750 PB - American Psychological Association, Washington DC VL - 78 IS - 5 SN - 0022-006X, 0022-006X KW - tele-mental health group psychotherapy posttraumatic stress disorder veterans video teleconferencing KW - Group therapy KW - Posttraumatic stress disorder KW - Attrition KW - Therapeutic alliances KW - Group psychotherapy KW - Anger KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/772252356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=How+Does+Tele-Mental+Health+Affect+Group+Therapy+Process%3F+Secondary+Analysis+of+a+Noninferiority+Trial&rft.au=Greene%2C+Carolyn+J%3BMorland%2C+Leslie+A%3BMacDonald%2C+Alexandra%3BFrueh%2C+B+Christopher%3BGrubbs%2C+Kathleen+M%3BRosen%2C+Craig+S&rft.aulast=Greene&rft.aufirst=Carolyn&rft.date=2010-10-01&rft.volume=78&rft.issue=5&rft.spage=746&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2Fa0020158 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-11-11 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Group psychotherapy; Attrition; Therapeutic alliances; Posttraumatic stress disorder; Group therapy; Anger DO - http://dx.doi.org/10.1037/a0020158 ER - TY - JOUR T1 - Effects of Midodrine Hydrochloride on Blood Pressure and Cerebral Blood Flow During Orthostasis in Persons With Chronic Tetraplegia AN - 954577681; 13870240 AB - Wecht JM, Rosado-Rivera D, Handrakis JP, Radulovic M, Bauman WA. Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia. Objective: To determine the mean arterial pressure (MAP) and middle cerebral artery mean blood flow velocity (MFV) responses to 5 and 10mg midodrine during head-up tilt (HUT) in persons with tetraplegia. Design: Prospective dose-response trial. Setting: James J. Peters Veterans Administration Medical Center. Participants: Persons (N=10) with chronic tetraplegia (duration of injury=23+/-11y). Intervention: A dose titration study was performed over 3 testing days: control (no drug), 5mg midodrine (5mg), or 10mg midodrine (10mg) during 30 minutes of baseline (predrug/no drug), 30 minutes of supine rest postdrug/no drug, 15 minutes of progressive HUT (5 minutes at 15, 25, 35), and 45 minutes of 45 HUT. Main Outcome Measures: MAP and MFV response to midodrine supine and during HUT. Results: Ten milligrams of midodrine significantly increased MAP while supine and during the HUT maneuver. Of note, the mean increase in MAP during HUT with 10mg was a result of a robust effect in 2 persons, with minimal change in the remaining 8 study subjects. The reduction in cerebral MFV during HUT was attenuated with 10mg. Conclusions: These findings suggest that midodrine 10mg may be efficacious for treatment of hypotension and orthostatic hypotension in select persons with tetraplegia. Although midodrine is routinely prescribed to treat orthostatic hypotension, the results of our work suggests limited efficacy of this agent, but additional studies in a larger sample of subjects with spinal cord injury should be performed. JF - Archives of Physical Medicine and Rehabilitation AU - Wecht, Jill M AU - Rosado-Rivera, Dwindally AU - Handrakis, John P AU - Radulovic, Miroslav AU - Bauman, William A AD - James J. Peters Veterans Administration Medical Center, Bronx, NY, Center of Excellence, JM.WECHT@VA.GOV Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1429 EP - 1435 PB - Elsevier BV, The Curtis Center, Independence Square West Philadelphia PA 19106-3399 USA VL - 91 IS - 9 SN - 0003-9993, 0003-9993 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Blood pressure KW - Hypotension KW - N3:11027 KW - X:24310 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954577681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Effects+of+Midodrine+Hydrochloride+on+Blood+Pressure+and+Cerebral+Blood+Flow+During+Orthostasis+in+Persons+With+Chronic+Tetraplegia&rft.au=Wecht%2C+Jill+M%3BRosado-Rivera%2C+Dwindally%3BHandrakis%2C+John+P%3BRadulovic%2C+Miroslav%3BBauman%2C+William+A&rft.aulast=Wecht&rft.aufirst=Jill&rft.date=2010-09-01&rft.volume=91&rft.issue=9&rft.spage=1429&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/10.1016%2Fj.apmr.2010.06.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Hypotension DO - http://dx.doi.org/10.1016/j.apmr.2010.06.017 ER - TY - JOUR T1 - The interrelationships between and contributions of background, cognitive, and environmental factors to colorectal cancer screening adherence AN - 899135397; 13751801 AB - Objectives: We examined the interrelationships between and contributions of background, cognitive, and environmental factors to colorectal cancer (CRC) screening adherence. Methods: In this study, 2,416 average risk patients aged 50-75 from 24 Veterans Affairs medical facilities responded to a mailed survey with phone follow-up (response rate 81%). Survey data (attitudes, behaviors, demographics) were linked to facility (organizational complexity) and medical records data (diagnoses, screening history). Patients with a fecal occult blood test within 15months, sigmoidoscopy or barium enema within 5.5years, or colonoscopy within 11years of the survey were considered adherent. Logistic regressions estimated the association between adherence and background, cognitive, and environmental factors. Deviance ratios examined interrelationships between factors. Population attributable risks (PAR) were used to identify intervention targets. Results: The association of background factors with adherence was partially explained by cognitive and environmental factors. The association of environmental factors with adherence was partially explained by cognitive factors. Cognitive and environmental factors contributed equally to adherence. Factors with the highest PARs for non-adherence were age 50-64, less than two comorbidities, and lack of physician recommendation. Conclusions: Efforts to increase physician screening recommendations for younger, healthy patients at facilities with the lowest screening rates may improve CRC adherence in this setting. JF - Cancer Causes & Control AU - Partin, Melissa R AU - Noorbaloochi, Siamak AU - Grill, Joseph AU - Burgess, Diana J AU - Ryn, Michelle AU - Fisher, Deborah A AU - Griffin, Joan M AU - Powell, Adam A AU - Halek, Krysten AU - Bangerter, Ann AU - Vernon, Sally W AD - Division of Health Promotion and Behavioral Sciences, University of Texas-Houston School of Public Health, 7000 Fannin Street, Suite 2560, Houston, TX, 77030, USA, melissa.partin@va.gov melissa.partin@va.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1357 EP - 1368 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 21 IS - 9 SN - 0957-5243, 0957-5243 KW - CSA Neurosciences Abstracts; Risk Abstracts KW - demography KW - Age KW - Colorectal cancer KW - Environmental factors KW - attitudes KW - Morbidity KW - Demography KW - Sigmoidoscopy KW - intervention KW - environmental factors KW - Fecal coliforms KW - Data processing KW - medical records KW - Cancer KW - Blood KW - colorectal carcinoma KW - Cognitive ability KW - Barium KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899135397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=The+interrelationships+between+and+contributions+of+background%2C+cognitive%2C+and+environmental+factors+to+colorectal+cancer+screening+adherence&rft.au=Partin%2C+Melissa+R%3BNoorbaloochi%2C+Siamak%3BGrill%2C+Joseph%3BBurgess%2C+Diana+J%3BRyn%2C+Michelle%3BFisher%2C+Deborah+A%3BGriffin%2C+Joan+M%3BPowell%2C+Adam+A%3BHalek%2C+Krysten%3BBangerter%2C+Ann%3BVernon%2C+Sally+W&rft.aulast=Partin&rft.aufirst=Melissa&rft.date=2010-09-01&rft.volume=21&rft.issue=9&rft.spage=1357&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-010-9563-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Demography; Blood; Sigmoidoscopy; Age; Data processing; medical records; Cognitive ability; Barium; Colorectal cancer; Environmental factors; demography; environmental factors; Fecal coliforms; colorectal carcinoma; intervention; Morbidity; attitudes; Cancer DO - http://dx.doi.org/10.1007/s10552-010-9563-0 ER - TY - JOUR T1 - Ototoxicity risk assessment combining distortion product otoacoustic emissions with a cisplatin dose model AN - 839682908; 14084020 AB - An objective method for identifying ototoxic hearing loss among patients receiving cisplatin is necessary since the ability of patients to take a behavioral test may change over the course of treatment. Data from 56 monitoring visits by 19 Veterans taking cisplatin were used to identify combinations of distortion-product otoacoustic emission (DPOAE) metrics and ototoxicity risk factors that best identified ototoxic hearing loss. Models were tested that incorporated DPOAE metrics generated statistically using partial least-squares analysis. Models were also tested that incorporated a priori DPOAE change criteria, such as a minimum DPOAE level shift of 6 dB. Receiver Operating Characteristic analysis was used to compare the accuracy of these models. The best performing model incorporated weighted combinations of pre-treatment hearing, cumulative cisplatin dose and DPOAE metrics that were determined using partial least-squares and evaluated over a quarter octave range near each subjects' high frequency DPOAE limit. Using this model and the DPOAE recording methods described herein, the chance of ototoxic hearing change can be determined at any given observed change in DPOAE level. This approach appears to provide an accurate and rapid ototoxicity risk assessment (ORA) that once validated can be used clinically. JF - Journal of the Acoustical Society of America AU - Dille, M F AU - McMillan, G P AU - Reavis, K M AU - Jacobs, P AU - Fausti, SA AU - Konrad-Martin, D AD - National Center for Rehabilitative Auditory Research, VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, USA, marilyn.dille@va.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1163 EP - 1174 PB - Acoustical Society of America, Suite 1NO1 2 Huntington Quadrangle Melville NY 11747-4502 USA VL - 128 IS - 3 SN - 0001-4966, 0001-4966 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Risk assessment KW - otoacoustic emissions KW - Data processing KW - Cisplatin KW - Auditory system KW - Ototoxicity KW - Risk factors KW - Statistical analysis KW - Hearing loss KW - Models KW - N3 11001:Behavioral and Cognitive Neuroscience KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839682908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Acoustical+Society+of+America&rft.atitle=Ototoxicity+risk+assessment+combining+distortion+product+otoacoustic+emissions+with+a+cisplatin+dose+model&rft.au=Dille%2C+M+F%3BMcMillan%2C+G+P%3BReavis%2C+K+M%3BJacobs%2C+P%3BFausti%2C+SA%3BKonrad-Martin%2C+D&rft.aulast=Dille&rft.aufirst=M&rft.date=2010-09-01&rft.volume=128&rft.issue=3&rft.spage=1163&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/10.1121%2F1.3473693 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Risk assessment; otoacoustic emissions; Data processing; Cisplatin; Auditory system; Risk factors; Ototoxicity; Statistical analysis; Hearing loss; Models DO - http://dx.doi.org/10.1121/1.3473693 ER - TY - JOUR T1 - Healthcare costs of Staphylococcus aureus and Clostridium difficile infections in Veterans: role of vitamin D deficiency AN - 815540556; 13937305 AB - Clostridium difficile and staphylococcal infections are associated with increased morbidity, mortality and healthcare costs. Vitamin D deficiency may also contribute to increased healthcare costs. There is increasing evidence that vitamin D may have an antimicrobial role. We examined the relationship of serum 25(OH)D levels to staphylococcal and C. difficile infections to determine if vitamin D deficiency was associated with adverse outcomes. In the outpatient setting, vitamin D deficiency in patients with C. difficile and staphylococcal infections were associated with significantly increased total outpatients costs and fee-based consultation. Laboratory expenses had a trend towards higher costs in the vitamin D-deficient group but did not reach statistical significance. The differences were most clearly seen in the in-patient group with enhanced laboratory, pharmacy and radiology costs. These differences resulted in vitamin D-deficient patients with C. difficile or staphylococcal infections having costs more than five times higher than the non-deficient patients. The total length of hospital stay was four times greater in the vitamin D-deficient group. In addition, the total number of hospitalizations was also significantly greater in the vitamin D-deficient group. Surgery costs demonstrated a tendency to be higher in the vitamin D-deficient group but failed to reach statistical significance. Vitamin D deficiency is intimately linked to adverse health outcomes and costs in Veterans with staphylococcal and C. difficile infections in North East Tennessee. We recommend that vitamin D status be checked in patients with these infections and appropriate therapy be instituted to restore vitamin D level to normal in an expeditious manner. JF - Epidemiology and Infection AU - Youssef, D AU - Bailey, B AU - El Abbassi, A AU - Copeland, R AU - Adebonojo, L AU - Manning, T AU - Peiris, An Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1322 EP - 1327 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU UK VL - 138 IS - 9 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts B: Bacteriology; Water Resources Abstracts; Aqualine Abstracts KW - Antimicrobial agents KW - USA, Tennessee KW - Vitamin D KW - Vitamins KW - Clostridium difficile KW - AQ 00001:Water Resources and Supplies KW - J:02400 KW - SW 7060:Research facilities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815540556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Healthcare+costs+of+Staphylococcus+aureus+and+Clostridium+difficile+infections+in+Veterans%3A+role+of+vitamin+D+deficiency&rft.au=Youssef%2C+D%3BBailey%2C+B%3BEl+Abbassi%2C+A%3BCopeland%2C+R%3BAdebonojo%2C+L%3BManning%2C+T%3BPeiris%2C+An&rft.aulast=Youssef&rft.aufirst=D&rft.date=2010-09-01&rft.volume=138&rft.issue=9&rft.spage=1322&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268809991543 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Vitamin D; Vitamins; Clostridium difficile; USA, Tennessee DO - http://dx.doi.org/10.1017/S0950268809991543 ER - TY - JOUR T1 - NOT SUPPOSED TO FEEL THIS: TRADITIONAL MASCULINITY IN PSYCHOTHERAPY WITH MALE VETERANS RETURNING FROM AFGHANISTAN AND IRAQ AN - 772262422; 201030366 AB - Traditional masculine socialization presents challenges in psychotherapy, for example, by decreasing the likelihood of help-seeking and by making emotion-laden content more difficult to address. While this has been established in civilian populations, more intense forms of masculine socialization found in military settings may amplify such issues in male veteran populations. Male veterans returning from and Afghanistan (OEF) and Iraq (OIF) exhibit strong traditional masculine socialization and generally present in a unique manner. It is posited that OEF/OIF male veterans' unique presentation is in large part because of an interaction between high degrees of endorsement of traditional masculine gender role norms, relative youth, recency of distressing events, and recent experience in the social context of the military where traditional masculinity is reinforced. The impact of these variables on the psychotherapeutic process for male OEF/OIF veterans is significant and likely adds to ambivalence about change and increases dropout from psychotherapy. Modifications of traditional psychotherapeutic approaches designed to address traditional masculine gender role norms and their many interactions with other variables are discussed. [Copyright Educational Publishing Foundation.] JF - Psychotherapy: Theory/Research/Practice/Training AU - Lorber, William AU - Garcia, Hector A Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 296 EP - 305 PB - American Psychological Association, Washington DC VL - 47 IS - 3 SN - 0033-3204, 0033-3204 KW - military veterans masculinity emotion posttraumatic stress disorder prolonged exposure KW - Veterans KW - Masculinity KW - Men KW - Psychotherapy KW - Socialization KW - Iraq KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/772262422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychotherapy%3A+Theory%2FResearch%2FPractice%2FTraining&rft.atitle=NOT+SUPPOSED+TO+FEEL+THIS%3A+TRADITIONAL+MASCULINITY+IN+PSYCHOTHERAPY+WITH+MALE+VETERANS+RETURNING+FROM+AFGHANISTAN+AND+IRAQ&rft.au=Lorber%2C+William%3BGarcia%2C+Hector+A&rft.aulast=Lorber&rft.aufirst=William&rft.date=2010-09-01&rft.volume=47&rft.issue=3&rft.spage=296&rft.isbn=&rft.btitle=&rft.title=Psychotherapy%3A+Theory%2FResearch%2FPractice%2FTraining&rft.issn=00333204&rft_id=info:doi/10.1037%2Fa0021161 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-11-11 N1 - Last updated - 2016-09-27 N1 - CODEN - PYSOAD N1 - SubjectsTermNotLitGenreText - Masculinity; Veterans; Psychotherapy; Men; Socialization; Iraq DO - http://dx.doi.org/10.1037/a0021161 ER - TY - JOUR T1 - Measuring PTSD Course Among Substance Use Disorder Patients: A Pilot Study of the Interrater Reliability and Validity of the Longitudinal Interval Follow-Up Evaluation (LIFE) AN - 759317707; 13669648 AB - Posttraumatic stress disorder (PTSD) and substance use disorders (SUDs) often co-occur. Methods that can map symptom occurrences over time may shed light on the potential etiological and maintaining factors of such complex symptom presentations. The Longitudinal Follow-Up Evaluation (LIFE) is an assessment method that has been used to characterize the weekly course of psychiatric disorder. This pilot study examined the interrater reliability and concurrent validity of LIFE to assess PTSD and substance dependence symptom course over a period of 26 weeks among SUD outpatients (N = 35). Participants with trauma histories completed interviews, including the LIFE for the prior 6 months, and questionnaires. All interviews were scored by a second rater. Results indicated good interrater reliability for the weekly psychiatric status ratings (PSRs). Associations between PTSD and SUD PSRs with alternative measures of PTSD, substance use and abuse, and functional status supported the validity of the PSRs. These data suggest that the LIFE is a reliable and valid method to measure weekly symptoms of PTSD. This method may prove helpful in mapping the course of PTSD--SUD and, as such, allowing more rigorous tests of process-related models of PTSD and SUD such as self-medication. JF - Traumatology AU - Ouimette, Paige AU - Wade, Michael AU - Coolhart, Deborah AU - Tirone, Vanessa AU - Goodwin, Elizabeth AU - Semenec, Silvie AD - Center for Integrated Healthcare, Syracuse VA Medical Center, Syracuse, NY, USA, Syracuse University, Syracuse, NY, USA, SUNY Upstate Medical University, Syracuse, NY, USA, paigec.ouimette@va.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 19 EP - 26 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 16 IS - 3 SN - 1534-7656, 1534-7656 KW - Health & Safety Science Abstracts KW - Historical account KW - posttraumatic stress disorder KW - Psychology KW - substance use KW - Mapping KW - mental disorders KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759317707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traumatology&rft.atitle=Measuring+PTSD+Course+Among+Substance+Use+Disorder+Patients%3A+A+Pilot+Study+of+the+Interrater+Reliability+and+Validity+of+the+Longitudinal+Interval+Follow-Up+Evaluation+%28LIFE%29&rft.au=Ouimette%2C+Paige%3BWade%2C+Michael%3BCoolhart%2C+Deborah%3BTirone%2C+Vanessa%3BGoodwin%2C+Elizabeth%3BSemenec%2C+Silvie&rft.aulast=Ouimette&rft.aufirst=Paige&rft.date=2010-09-01&rft.volume=16&rft.issue=3&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F1534765610368570 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Historical account; posttraumatic stress disorder; Psychology; substance use; Mapping; mental disorders DO - http://dx.doi.org/10.1177/1534765610368570 ER - TY - JOUR T1 - Evaluation of an Electronic Clinical Reminder to Facilitate Brief Alcohol-Counseling Interventions in Primary Care AN - 758115266; 201029432 AB - Objective: Brief intervention for patients with unhealthy alcohol use is a prevention priority in the United States, but most eligible patients do not receive it. This study evaluated an electronic alcohol-counseling clinical reminder at a single Veterans Affairs general medicine clinic. Method: The systems-level intervention evaluated in this study consisted of making the clinical reminder, which facilitated medical record documentation of brief intervention among patients who screened positive for unhealthy alcohol use, available to providers on one (of two) randomly selected hallways. Secondary electronic data were extracted for all patients who visited the clinic (October 1, 2002, to September 30, 2005). The proportion of patients with clinical-reminder use was evaluated among patients who screened positive for unhealthy drinking and were assigned to intervention hallway providers ("descriptive cohort"). Adjusted logistic regression evaluated the association between the intervention and resolution of unhealthy drinking at follow-up among all screen-positive patients who completed a second Alcohol Use Disorders Identification Test Consumption questionnaire 18 months or longer after the first ("outcomes cohort"). Results: Eligible patients (N= 22,863) included 10,392 controls and 12,471 in the intervention group. Fifteen percent (398 of 2,640) of descriptive cohort patients with unhealthy drinking had clinical-reminder use, which varied by severity (14% [n = 302 of 2,165] with mild/moderate and 20% [n = 96 of 475] with severe unhealthy drinking, p = .001). Only 39% (156 of 398) of patients with clinical-reminder use had documented brief intervention; advice to abstain was most common. Access to the clinical reminder was not significantly associated with resolution of unhealthy drinking in 1,358 patients in the outcomes cohort. Conclusions: Availability of a clinical reminder to facilitate brief intervention did not, alone, result in substantial use of the clinical reminder. More active implementation efforts may be needed to get brief interventions onto the agenda of busy primary care providers. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Williams, Emily C AU - Achtmeyer, Carol E AU - Kivlahan, Daniel R AU - Greenberg, Diane AU - Merrill, Joseph O AU - Wickizer, Thomas M AU - Koepsell, Thomas D AU - Heagerty, Patrick J AU - Bradley, Katharine A AD - Health Services Research and Development and Center of Excellence in Substance Abuse Treatment and Education, Veterans Affairs Puget Sound Health Care System, 1100 Olive Way, Suite 1400, Seattle, Washington 98101 emily.williams3@va.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 720 EP - 725 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 71 IS - 5 SN - 1937-1888, 1937-1888 KW - Alcohol consumption KW - Reminders KW - Interventions KW - Brief interventions KW - Primary health care KW - Clinics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758115266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Evaluation+of+an+Electronic+Clinical+Reminder+to+Facilitate+Brief+Alcohol-Counseling+Interventions+in+Primary+Care&rft.au=Williams%2C+Emily+C%3BAchtmeyer%2C+Carol+E%3BKivlahan%2C+Daniel+R%3BGreenberg%2C+Diane%3BMerrill%2C+Joseph+O%3BWickizer%2C+Thomas+M%3BKoepsell%2C+Thomas+D%3BHeagerty%2C+Patrick+J%3BBradley%2C+Katharine+A&rft.aulast=Williams&rft.aufirst=Emily&rft.date=2010-09-01&rft.volume=71&rft.issue=5&rft.spage=720&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alcohol consumption; Reminders; Brief interventions; Interventions; Clinics; Primary health care ER - TY - JOUR T1 - The K1 Capsular Polysaccharide of Acinetobacter baumannii Strain 307-0294 Is a Major Virulence Factor AN - 754896177; 13527177 AB - Acinetobacter baumannii is a pathogen of increasing medical importance with a propensity to be multidrug resistant, thereby making treatment challenging. Little is known of virulence traits in A. baumannii. To identify virulence factors and potential drug targets, random transposon (Tn) mutants derived from the A. baumannii strain AB307-0294 were screened to identify genes essential for growth in human ascites fluid in vitro, an inflammatory exudative fluid. These studies led to the identification of two genes that were predicted to be required for capsule polymerization and assembly. The first, ptk, encodes a putative protein tyrosine kinase (PTK), and the second, epsA, encodes a putative polysaccharide export outer membrane protein (EpsA). Monoclonal antibodies used in flow cytometric and Western analyses confirmed that these genes are required for a capsule-positive phenotype. A capsule-positive phenotype significantly optimized growth in human ascites fluid, survival in human serum, and survival in a rat soft tissue infection model. Importantly, the clearance of the capsule-minus mutants AB307.30 (ptk mutant, capsule minus) and AB307.45 (epsA mutant, capsule minus) was complete and durable. These data demonstrated that the K1 capsule from AB307-0294 was an important protectin. Further, these data suggested that conserved proteins, which contribute to the capsule-positive phenotype, are potential antivirulence drug targets. Therefore, the results from this study have important biologic and translational implications and, to the best of our knowledge, are the first to address the role of capsule in the pathogenesis of A. baumannii infection. JF - Infection and Immunity AU - Russo, Thomas A AU - Luke, Nicole R AU - Beanan, Janet M AU - Olson, Ruth AU - Sauberan, Shauna L AU - MacDonald, Ulrike AU - Schultz, LWayne AU - Umland, Timothy C AU - Campagnari, Anthony A AD - Veterans Administration Western New York Healthcare System, Buffalo, New York, trusso@acsu.buffalo.edu Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 3993 EP - 4000 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 9 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Translation KW - Polymerization KW - Data processing KW - outer membrane proteins KW - virulence factors KW - Monoclonal antibodies KW - Animal models KW - Medical importance KW - Survival KW - Pathogens KW - Infection KW - Inflammation KW - Transposons KW - Flow cytometry KW - Acinetobacter baumannii KW - Ascites KW - Protein-tyrosine kinase KW - Multidrug resistance KW - Drugs KW - Capsular polysaccharides KW - Soft tissues KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754896177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=The+K1+Capsular+Polysaccharide+of+Acinetobacter+baumannii+Strain+307-0294+Is+a+Major+Virulence+Factor&rft.au=Russo%2C+Thomas+A%3BLuke%2C+Nicole+R%3BBeanan%2C+Janet+M%3BOlson%2C+Ruth%3BSauberan%2C+Shauna+L%3BMacDonald%2C+Ulrike%3BSchultz%2C+LWayne%3BUmland%2C+Timothy+C%3BCampagnari%2C+Anthony+A&rft.aulast=Russo&rft.aufirst=Thomas&rft.date=2010-09-01&rft.volume=78&rft.issue=9&rft.spage=3993&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00366-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Translation; outer membrane proteins; Data processing; Polymerization; virulence factors; Monoclonal antibodies; Animal models; Survival; Medical importance; Pathogens; Infection; Inflammation; Flow cytometry; Transposons; Ascites; Protein-tyrosine kinase; Multidrug resistance; Soft tissues; Capsular polysaccharides; Drugs; Acinetobacter baumannii DO - http://dx.doi.org/10.1128/IAI.00366-10 ER - TY - JOUR T1 - Teaching residents to communicate: The use of a telephone triage system in an academic ambulatory clinic AN - 754141213; 201024679 AB - Objective This study evaluated the use of a telephone triage system in an academic primary care clinic and its impact on communication, patient management and satisfaction. Methods A 'telephone clinic' was created using a triage nurse to answer patients' calls to an academic primary care clinic, staffed by house staff physicians. Chart reviews were conducted of all medical records of patients who called and were referred to the telephone clinic during a six month period. A total of 1135 patient calls were monitored. Using a random selection process, 366 patient calls were studied and 42% of these patients were called back two weeks after the initial call and were interviewed. Results Of the 336 calls, 68% of the calls were serious enough to be referred to a house staff physician. Symptom complaints accounted for 64% of the telephone calls; 4% of patients were sent to the emergency room or admitted to the hospital directly based on the information from the call. Telephone calls enhanced patients' access to specialty care consultative services and 14% of patients who called received a new medication prescription. Patients' satisfaction with the communication and the overall care provided by the 'telephone clinic' was highly rated. Conclusion The telephone contact initiated by the patients resulted in expedited access for patients whose symptoms were serious enough to require immediate referral to the emergency room or direct hospital admission. Practice implications In a primary care practice, the telephone can be a major source of communication for practitioners, office staff and patients. The creation of a 'telephone clinic' which utilizes nurses and house staff physicians trained and dedicated to telephone communication directly with patients resulted in more efficient management and greater satisfaction for patients. [Copyright Elsevier B.V.] JF - Patient Education and Counseling AU - Caralis, Panagiota AD - Department of Medicine, University of Miami Miller school of Medicine, Veterans Affairs Medical Center, 1201 NW 16 Street, Miami, FL 33125, USA Panagiota.Caralis@va.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 351 EP - 353 PB - Elsevier Ltd, The Netherlands VL - 80 IS - 3 SN - 0738-3991, 0738-3991 KW - Residents Telephone triage satisfaction Primary care clinic KW - Telephones KW - Houses KW - Doctors KW - Patient satisfaction KW - Triage KW - Clinics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754141213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Patient+Education+and+Counseling&rft.atitle=Teaching+residents+to+communicate%3A+The+use+of+a+telephone+triage+system+in+an+academic+ambulatory+clinic&rft.au=Caralis%2C+Panagiota&rft.aulast=Caralis&rft.aufirst=Panagiota&rft.date=2010-09-01&rft.volume=80&rft.issue=3&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Patient+Education+and+Counseling&rft.issn=07383991&rft_id=info:doi/10.1016%2Fj.pec.2010.07.028 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-09-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Telephones; Clinics; Houses; Patient satisfaction; Doctors; Triage DO - http://dx.doi.org/10.1016/j.pec.2010.07.028 ER - TY - JOUR T1 - The cost of concordance with opiate substitution treatment guidelines AN - 754141160; 201024410 AB - The Multisite Opiate Substitution Treatment study compared four opioid substitution programs that were highly concordant with clinical practice guidelines to four programs that were less concordant. Program staff were surveyed, and consenting new patients from highly concordant (n = 164) and less-concordant programs (n = 91) were assessed. After 12 months, treatment of new clients of highly staffed, guideline concordant sites cost $10,252, which is significantly more than the $6,476 cost at less-concordant programs (p < .01). Clients at highly concordant sites received significantly more group visits (M = 37.0 vs. 13.1, p < .01) but fewer dosing visits. There were no significant differences in medical care costs. Opioid substitution therapy was effective at reducing heroin use, especially at sites that were highly concordant with treatment guidelines. Annual mortality was 3.0% and did not differ by type of care. Preference-based quality of life significantly improved only at highly concordant sites. [Copyright Elsevier Inc.] JF - Journal of Substance Abuse Treatment AU - Barnett, Paul G AU - Trafton, Jodie A AU - Humphreys, Keith AD - VA Health Economics Resource Center (HERC), VA Palo Alto Health Care System, CA 94025, USA paul.barnett@va.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 141 EP - 149 PB - Elsevier, New York NY VL - 39 IS - 2 SN - 0740-5472, 0740-5472 KW - MOST study Opioid substitution program Concordance Cost KW - Mortality KW - Opiates KW - Health care KW - Concordance KW - Opioids KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754141160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=The+cost+of+concordance+with+opiate+substitution+treatment+guidelines&rft.au=Barnett%2C+Paul+G%3BTrafton%2C+Jodie+A%3BHumphreys%2C+Keith&rft.aulast=Barnett&rft.aufirst=Paul&rft.date=2010-09-01&rft.volume=39&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/10.1016%2Fj.jsat.2010.05.012 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Opioids; Opiates; Concordance; Quality of life; Mortality; Health care DO - http://dx.doi.org/10.1016/j.jsat.2010.05.012 ER - TY - JOUR T1 - Psychometric Properties of the State-Trait Inventory for Cognitive and Somatic Anxiety (STICSA) in Friendship Dyads AN - 754136356; 201021231 AB - Recently, Gros, Antony, Simms, and McCabe (2007) demonstrated support for the psychometric properties of a new measure of state and trait anxiety, the State-Trait Inventory for Cognitive and Somatic Anxiety (STICSA). In the present study, we further investigated the STICSA-Trait Version in 127 friendship dyads with a self-report from one participant (target) and an other-report of the target from a friend (informant). Consistent with previous research, confirmatory factor analyses supported the 2-factor structure of the STICSA-Trait in the target and informant reports. Moreover, the STICSA-Trait Cognitive and Somatic Anxiety subscales showed acceptable convergent and discriminant validity with related measures of anxiety. In addition, the STICSA-Trait subscales demonstrated adequate internal consistency and self-other agreement across the target and informant reports. Together, these findings provide additional support for the STICSA-Trait subscales as reliable and valid measures of cognitive and somatic anxiety. [Copyright Association for Behavioral and Cognitive Therapies. Published by Elsevier Ltd.] JF - Behavior Therapy AU - Gros, Daniel F AU - Simms, Leonard J AU - Antony, Martin M AD - Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC, Medical University of South Carolina, Charleston grosd@musc.edu Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 277 EP - 284 PB - Elsevier Ltd, The Netherlands VL - 41 IS - 3 SN - 0005-7894, 0005-7894 KW - Trait anxiety KW - Anxiety KW - Psychometric properties KW - Selfreport KW - Friendships KW - Informants KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754136356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Therapy&rft.atitle=Psychometric+Properties+of+the+State-Trait+Inventory+for+Cognitive+and+Somatic+Anxiety+%28STICSA%29+in+Friendship+Dyads&rft.au=Gros%2C+Daniel+F%3BSimms%2C+Leonard+J%3BAntony%2C+Martin+M&rft.aulast=Gros&rft.aufirst=Daniel&rft.date=2010-09-01&rft.volume=41&rft.issue=3&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Behavior+Therapy&rft.issn=00057894&rft_id=info:doi/10.1016%2Fj.beth.2009.07.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Anxiety; Informants; Psychometric properties; Friendships; Selfreport; Trait anxiety DO - http://dx.doi.org/10.1016/j.beth.2009.07.001 ER - TY - JOUR T1 - INa and IKir are reduced in Type 1 hypokalemic and thyrotoxic periodic paralysis. AN - 749026429; 20589886 AB - We evaluated voltage-gated Na(+) (I(Na)) and inward rectifier K(+) (I(Kir)) currents and Na(+) conductance (G(Na)) in patients with Type 1 hypokalemic (HOPP) and thyrotoxic periodic paralysis (TPP). We studied intercostal muscle fibers from five subjects with HOPP and one with TPP. TPP was studied when the patient was thyrotoxic (T-toxic) and euthyroid. We measured: (1) I(Kir), (2) action potential thresholds, (3) I(Na), (4) G(Na), (5) intracellular [Ca(2+)], and (6) histochemical fiber type. HOPP fibers had lower I(Na), G(Na), and I(Kir) and increased action potential thresholds. Paralytic attack frequency correlated with the action potential threshold, G(Na) and I(Na), but not with I(Kir). G(Na), I(Na), and [Ca(2+)] varied with fiber type. HOPP fibers had increased [Ca(2+)]. The subject with TPP had values for G(Na), I(Na), action potential threshold, I(Kir), and [Ca(2+)] that were similar to HOPP when T-toxic and to controls when euthyroid. HOPP T-toxic TPP fibers had altered G(Na), I(Na), and I(Kir) associated with elevation in [Ca(2+)]. JF - Muscle & nerve AU - Puwanant, Araya AU - Ruff, Robert L AD - Louis Stokes Cleveland Veterans Administration Medical Center, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA. Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 315 EP - 327 VL - 42 IS - 3 KW - Insulin KW - 0 KW - Potassium Channels, Inwardly Rectifying KW - Sodium Channels KW - DNA KW - 9007-49-2 KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Muscle Weakness -- etiology KW - Muscle, Skeletal -- pathology KW - Action Potentials -- physiology KW - Muscle Fibers, Skeletal -- physiology KW - Humans KW - Insulin -- pharmacology KW - Electrophysiology KW - Histocytochemistry KW - DNA -- genetics KW - Potassium -- pharmacology KW - Family KW - Membrane Potentials -- drug effects KW - Cell Membrane -- metabolism KW - Muscle, Skeletal -- metabolism KW - Male KW - Microelectrodes KW - Thyrotoxicosis -- metabolism KW - Hypokalemic Periodic Paralysis -- metabolism KW - Thyrotoxicosis -- genetics KW - Hypokalemic Periodic Paralysis -- pathology KW - Sodium Channels -- physiology KW - Hypokalemic Periodic Paralysis -- genetics KW - Potassium Channels, Inwardly Rectifying -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749026429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Muscle+%26+nerve&rft.atitle=INa+and+IKir+are+reduced+in+Type+1+hypokalemic+and+thyrotoxic+periodic+paralysis.&rft.au=Puwanant%2C+Araya%3BRuff%2C+Robert+L&rft.aulast=Puwanant&rft.aufirst=Araya&rft.date=2010-09-01&rft.volume=42&rft.issue=3&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Muscle+%26+nerve&rft.issn=1097-4598&rft_id=info:doi/10.1002%2Fmus.21693 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-16 N1 - Date created - 2010-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mus.21693 ER - TY - JOUR T1 - Insulin Glargine and Cancer Risk: An Opinion Statement of the Endocrine and Metabolism Practice and Research Network of the American College of Clinical Pharmacy AN - 1837298467; 20885909 AB - Diabetes mellitus has reached epidemic proportions worldwide, eliciting extensive research on both the disease process and its treatment. Regardless of diabetes type, the progressive nature of the disease makes insulin the long-term mainstay of diabetes management. Recently, the insulin analog glargine was reported in several epidemiologic studies to be associated with an increased risk of cancer. Inconsistent study results and media attention have caused much angst and concern to health care professionals and the general population. A clear understanding of the current evidence is needed to adequately develop a patient-oriented risk:benefit assessment. Members of the Endocrine and Metabolism Practice and Research Network of the American College of Clinical Pharmacy evaluated available evidence to provide guidance and discussion on the risk of cancer with insulin glargine use. We believe the current link between insulin glargine and cancer is tenuous but merits further evaluation. An independent analysis of all available glargine clinical trial data should be performed, and a vigorous postmarketing safety study of glargine should be conducted. Until more substantial data are available, however, neither the choice of initial insulin therapy nor insulin maintenance regimens should be influenced by the current information linking insulin glargine to cancer. JF - Pharmacotherapy AU - Edwards, Krystal L AU - Riche, Daniel M AU - Stroup, Jeffrey S AU - Goldman-Levine, Jennifer D AU - Padiyara, Rosalyn S AU - Cross, LBrian AU - Kane, Michael P AD - Department of Pharmacy Practice, School of Pharmacy, Texas Tech University Health Sciences Center, and the Veterans Administration North Texas Health Care System, Dallas, Texas. Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 955 EP - 965 PB - Wiley-Blackwell, Commerce Pl, 350 Main St Maiden MA 02148 United States VL - 30 IS - 9 SN - 0277-0008, 0277-0008 KW - Toxicology Abstracts KW - Diabetes mellitus KW - Data processing KW - Epidemics KW - Clinical trials KW - Insulin KW - Cancer KW - Metabolism KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837298467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Insulin+Glargine+and+Cancer+Risk%3A+An+Opinion+Statement+of+the+Endocrine+and+Metabolism+Practice+and+Research+Network+of+the+American+College+of+Clinical+Pharmacy&rft.au=Edwards%2C+Krystal+L%3BRiche%2C+Daniel+M%3BStroup%2C+Jeffrey+S%3BGoldman-Levine%2C+Jennifer+D%3BPadiyara%2C+Rosalyn+S%3BCross%2C+LBrian%3BKane%2C+Michael+P&rft.aulast=Edwards&rft.aufirst=Krystal&rft.date=2010-09-01&rft.volume=30&rft.issue=9&rft.spage=955&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/10.1592%2Fphco.30.9.955 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Epidemics; Data processing; Clinical trials; Metabolism; Cancer; Insulin DO - http://dx.doi.org/10.1592/phco.30.9.955 ER - TY - JOUR T1 - Comparison of once-daily versus twice-daily dosing of valsartan in patients with chronic stable heart failure AN - 877581422; 13710929 AB - The safety of once-daily (qd) dosing of valsartan in heart failure (HF) patients is not known. This 10-week, double-blind trial examined the relative safety and efficacy of valsartan administered qd versus twice-daily (bid). HF patients (NYHA class II-III) receiving diuretics (87%), angiotensin-converting enzyme inhibitors (98%), beta-blockers (92%), aldosterone antagonists (25%), or digoxin (32%) were randomized to valsartan 40 mg bid (n = 60) or 80 mg qd (n = 55) and titrated to a maximum dose of 320 mg/day; doubling the dose every 2 weeks. Clinical and biochemical parameters were measured at Weeks 2, 4, 6, and 10. The average dose of valsartan at the end of study was 245 mg in the bid group vs 256 mg in the qd group (P = NS). Similar proportions of patients tolerated qd vs bid dosing (bid 67% vs qd 68%). Outcome measures including reduction in blood pressure, incidence of hypotension, renal impairment, orthostatic dizziness or fatigue, changes in serum K+, creatinine, cystatin-C, and estimated glomerular filtration rate were similar between the 2 groups at all time-points. Brain natriuretic peptide levels decreased and plasma renin activity increased from baseline by the same amount in both groups at all time-points. Valsartan administered qd has a similar safety and tolerability profile with comparable 24-hour RAAS blockade, as assessed by increases in PRA, as bid dosing in patients with moderate to severe (NYHA class II-III) heart failure. JF - Vascular Health and Risk Management AU - Anand, Inder S AU - Deswal, Anita AU - Kereiakes, Dean J AU - Purkayastha, Das AU - Zappe, Dion H AD - Veterans Administration Medical Center, Minneapolis, MN, USA Y1 - 2010/08/09/ PY - 2010 DA - 2010 Aug 09 SP - 449 EP - 455 PB - Dove Medical Press Ltd, Beechfield House Macclesfield SK11 0JL UK VL - 6 SN - 1176-6344, 1176-6344 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877581422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vascular+Health+and+Risk+Management&rft.atitle=Comparison+of+once-daily+versus+twice-daily+dosing+of+valsartan+in+patients+with+chronic+stable+heart+failure&rft.au=Anand%2C+Inder+S%3BDeswal%2C+Anita%3BKereiakes%2C+Dean+J%3BPurkayastha%2C+Das%3BZappe%2C+Dion+H&rft.aulast=Anand&rft.aufirst=Inder&rft.date=2010-08-09&rft.volume=6&rft.issue=&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Vascular+Health+and+Risk+Management&rft.issn=11766344&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Incorporating Complementary and Alternative Medicine (CAM) Therapies to Expand Psychological Services to Veterans Suffering From Chronic Pain AN - 822498032; 201032654 AB - This article describes how psychological services for Veterans being seen in an interdisciplinary pain management program were expanded to include Complementary and Alternative Medicine (CAM) approaches. The benefits observed following the introduction of CAM therapies included: improved attendance and Veterans' involvement in group-based therapies, reductions in self-reported pain and anxiety, improved sleep, and an increased sense of emotional well being in the participants. The data also show that CAM therapies, when offered as a treatment option in the format of a drop-in group clinic, were associated with a modest but significant average pain reduction of 1.02 units on a 0-10 Numerical Rating scale. The CAM therapies described in this program are relatively inexpensive and portable, and can appear to the patient as conventional Western or 'real' medical treatment (and perhaps, therefore, have less stigma than psychotherapy) for pain and associated distress. They also require minimal training to use and, therefore, can be used as a self-treatment at home. If proven to be effective in future controlled trials, their use could improve access to effective pain care, particularly for Veterans residing in the rural settings. [Copyright Elsevier B.V.] JF - Psychological Services AU - Tan, Gabriel AU - Dao, Tam K AU - Smith, Donna L AU - Robinson, Andrew AU - Jensen, Mark P AD - Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX tan.gabriel@va.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 148 EP - 161 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 7 IS - 3 SN - 1541-1559, 1541-1559 KW - expanding psychological services to veterans Complementary Alternative Medicine (CAM) chronic pain management cranial electrotherapy stimulation (CES) stress erasers KW - Suffering KW - Veterans KW - Psychological services KW - Chronic pain KW - Psychotherapy KW - Alternative medicine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822498032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Incorporating+Complementary+and+Alternative+Medicine+%28CAM%29+Therapies+to+Expand+Psychological+Services+to+Veterans+Suffering+From+Chronic+Pain&rft.au=Tan%2C+Gabriel%3BDao%2C+Tam+K%3BSmith%2C+Donna+L%3BRobinson%2C+Andrew%3BJensen%2C+Mark+P&rft.aulast=Tan&rft.aufirst=Gabriel&rft.date=2010-08-01&rft.volume=7&rft.issue=3&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0020304 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alternative medicine; Chronic pain; Veterans; Psychological services; Psychotherapy; Suffering DO - http://dx.doi.org/10.1037/a0020304 ER - TY - JOUR T1 - An Examination of the Co-Morbidity Between Chronic Pain and Posttraumatic Stress Disorder on U.S. Veterans AN - 822497870; 201032316 AB - The purpose of this study was to assess the comorbidity between chronic pain and posttraumatic stress disorder (PTSD) and examine the extent to which PTSD is associated with changes in the multidimensional experience of pain in a sample of Veterans with chronic pain. It was hypothesized that Veterans with comorbid chronic pain and PTSD would report significantly higher scores on measures of pain intensity, pain behaviors, pain-related disability, and affective distress than Veterans with pain alone. Data were obtained from 149 Veterans who completed self-report questionnaires as part of their participation in a Psychology Pain Management program at a northeastern Department of Veterans Affairs health care facility. Analyses indicated that 49% of the sample met criteria for PTSD. A multivariate analysis of covariance was conducted with age, sex, pain duration, and depressive symptom severity as covariates. In partial support of our hypothesis, the presence of PTSD was found to contribute significantly to measures of affective distress, even after controlling for the effects of depressive symptom severity. The implications of these data are discussed. [Copyright Elsevier B.V.] JF - Psychological Services AU - Otis, John D AU - Gregor, Kristin AU - Hardway, Christina AU - Morrison, Jay AU - Scioli, Erica AU - Sanderson, Kristen AD - VA Boston Healthcare System, Boston, MA john.otis@va.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 126 EP - 135 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 7 IS - 3 SN - 1541-1559, 1541-1559 KW - pain Veterans military personnel posttraumatic stress disorder wounds and injuries KW - Veterans KW - Severity KW - Posttraumatic stress disorder KW - Chronic pain KW - Psychological distress KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822497870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=An+Examination+of+the+Co-Morbidity+Between+Chronic+Pain+and+Posttraumatic+Stress+Disorder+on+U.S.+Veterans&rft.au=Otis%2C+John+D%3BGregor%2C+Kristin%3BHardway%2C+Christina%3BMorrison%2C+Jay%3BScioli%2C+Erica%3BSanderson%2C+Kristen&rft.aulast=Otis&rft.aufirst=John&rft.date=2010-08-01&rft.volume=7&rft.issue=3&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0020512 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Chronic pain; Posttraumatic stress disorder; Veterans; Comorbidity; Severity; Psychological distress DO - http://dx.doi.org/10.1037/a0020512 ER - TY - JOUR T1 - Psychologists as Change Agents in Chronic Pain Management Practice: Cultural Competence in the Health Care System AN - 822497348; 201031660 AB - Psychologists bring great value to health care systems, but our ethnocentrism regarding the medical community often limits our effectiveness as agents of change. Based on experience in developing pain management services within the Department of Veterans Affairs health care system, we discuss cultural issues as central to effective systems change and provide specific recommendations for psychologists aspiring to change organized health care systems, such as the Department of Veterans Affairs. Consideration is given to the misfit of the biomedical model to chronic pain, 'physics envy' affecting the authority accorded psychology, and societal stigmatization of psychopathology. A process-based definition of cultural competence is recommended as improving on psychology's intrinsic group-based notion of culture in engaging the medical community. The systems thinking literature is sampled in summarizing practical recommendations that include identifying features of local medical culture and power dynamics between psychology and medicine that can be modified by engaging stakeholders in an interpersonally effective manner. [Copyright Elsevier B.V.] JF - Psychological Services AU - Frohm, Karl D AU - Beehler, Gregory P AD - VA Western New York Healthcare System, Buffalo, NY karl.frohm@va.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 115 EP - 125 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 7 IS - 3 SN - 1541-1559, 1541-1559 KW - pain psychologists organizational culture cultural competence KW - Veterans KW - Change agents KW - Chronic pain KW - Health care KW - Psychology KW - Psychologists KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822497348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Psychologists+as+Change+Agents+in+Chronic+Pain+Management+Practice%3A+Cultural+Competence+in+the+Health+Care+System&rft.au=Frohm%2C+Karl+D%3BBeehler%2C+Gregory+P&rft.aulast=Frohm&rft.aufirst=Karl&rft.date=2010-08-01&rft.volume=7&rft.issue=3&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0019642 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Health care; Psychologists; Chronic pain; Psychology; Change agents; Veterans DO - http://dx.doi.org/10.1037/a0019642 ER - TY - JOUR T1 - Impact of Race on Early Treatment Termination and Outcomes in Posttraumatic Stress Disorder Treatment AN - 772262893; 201030339 AB - Objective:The present study investigated the influence of race on posttraumatic stress disorder (PTSD) treatment among 94 African American and 214 Caucasian female victims of interpersonal violence participating in 2 studies of cognitive-behavioral treatment for PTSD that were conducted sequentially and continuously. Method:In each study, participants were randomized into 1of 3 conditions. The first study compared cognitive processing therapy with prolonged exposure and a delayed treatment condition. In the second study, cognitive processing therapy was compared with its constituent components: cognitive therapy only and written accounts. Participants were assessed with the Clinician Administered PTSD Scale and the Structured Clinical Interview for DSM-IV, as well as through self-report measures of PTSD. Results:Analyses revealed that African Americans were significantly less likely to complete treatment compared with Caucasians (45% vs. 73%, respectively, p < .001) and that the differences held even after controlling for education and income. Despite racial differences in treatment completion status, analyses with the intent-to-treat sample indicated no racial differences in outcomes on PTSD measures. Conclusions:The lack of difference in treatment outcomes despite racial differences in dropout may be explained by greater symptom improvement of African Americans who dropped out compared with Caucasians who dropped out. Implications of these findings and practical approaches to addressing sociocultural barriers to care are explored. [Copyright American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Lester, Kristin AU - Resick, Patricia A AU - Young-Xu, Yinong AU - Artz, Caroline AD - Women's Health Sciences Division, National Center for PTSD, Veterans Affairs Boston Healthcare System kristin.lester@va.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 480 EP - 489 PB - American Psychological Association, Washington DC VL - 78 IS - 4 SN - 0022-006X, 0022-006X KW - African Americans posttraumatic stress disorder cognitive processing therapy prolonged exposure dropout KW - Clinical outcomes KW - Racial differences KW - Black American people KW - Posttraumatic stress disorder KW - Race KW - Cognitive processing KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/772262893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=Impact+of+Race+on+Early+Treatment+Termination+and+Outcomes+in+Posttraumatic+Stress+Disorder+Treatment&rft.au=Lester%2C+Kristin%3BResick%2C+Patricia+A%3BYoung-Xu%2C+Yinong%3BArtz%2C+Caroline&rft.aulast=Lester&rft.aufirst=Kristin&rft.date=2010-08-01&rft.volume=78&rft.issue=4&rft.spage=480&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2Fa0019551 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-11-11 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Black American people; Racial differences; Clinical outcomes; Cognitive processing; Race DO - http://dx.doi.org/10.1037/a0019551 ER - TY - JOUR T1 - Risk Factors for Attempting Suicide in Heroin Addicts AN - 758130227; 201059292 AB - In order to examine risk factors for attempting suicide in heroin dependent patients, a group of 527 abstinent opiate dependent patients had a psychiatric interview & completed the Childhood Trauma Questionnaire. Patients who had or had never attempted suicide were compared on putative suicide risk factors. It was found that 207 of the 527 heroin abusers (39.3%) had attempted suicide. Attempters were younger; more were female, reported childhood trauma, a family history of suicidal behavior, a history of aggression, treatment with antidepressant medication, & alcohol & cocaine dependence. Logistic regression revealed that a family history of suicidal behavior, alcohol dependence, cocaine dependence, & treatment with antidepressant medication were significant predictors of attempting suicide. These results suggest that attempting suicide is common among opiate dependent patients & that both distal & proximal risk factors may play a role. Adapted from the source document. JF - Suicide and Life-Threatening Behavior AU - Roy, Alec AD - Psychiatry Service, Dept Veterans Affairs, East Orange, NJ Alec.Roy@va.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 416 EP - 420 PB - Guilford Publications, New York NY VL - 40 IS - 4 SN - 0363-0234, 0363-0234 KW - Mental Patients KW - Heroin KW - Medications KW - Suicide KW - Patients KW - Mental Health Services KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758130227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Suicide+and+Life-Threatening+Behavior&rft.atitle=Risk+Factors+for+Attempting+Suicide+in+Heroin+Addicts&rft.au=Roy%2C+Alec&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2010-08-01&rft.volume=40&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Suicide+and+Life-Threatening+Behavior&rft.issn=03630234&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-12 N1 - Number of references - 16 N1 - Last updated - 2016-09-28 N1 - CODEN - SLBEDP N1 - SubjectsTermNotLitGenreText - Suicide; Patients; Heroin; Mental Patients; Mental Health Services; Medications ER - TY - JOUR T1 - A Model for Home-Based Psychology From the Veterans Health Administration AN - 758109611; 201028179 AB - The changing healthcare environment is creating opportunities for psychologists to practice in non-traditional settings. This paper describes a Veterans Health Administration (VA) initiative to integrate psychologists into its Home Based Primary Care (HBPC) program. As psychologists new to HBPC are learning, the home offers opportunities and challenges not routinely encountered in the traditional office setting. Home-based psychology offers improved access to mental health services, more effective treatment planning, and more accurate assessments in an underserved patient population. Psychologists practicing in this setting also encounter challenges in dealing with patient confidentiality, distractions, role confusion and boundaries, time management, safety, and professional competency. The VA experience is an instructive case example for psychologists considering this growing field of practice. This paper offers lessons learned from this VA initiative and discusses strategies for dealing with potential challenges. [Copyright Elsevier B.V.] JF - Professional Psychology: Research and Practice AU - Hicken, Bret L AU - Plowhead, Angela AD - George E. Wahlen VA Medical Center, Salt Lake City, UT bret.hicken@va.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 340 EP - 346 PB - American Psychological Association, Washington DC VL - 41 IS - 4 SN - 0735-7028, 0735-7028 KW - home care psychology and home based primary care therapy assessment homebound KW - Mental health services KW - Home based KW - Psychology KW - Underserved people KW - Confidentiality KW - Psychologists KW - Confusion KW - Health KW - Military hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758109611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Psychology%3A+Research+and+Practice&rft.atitle=A+Model+for+Home-Based+Psychology+From+the+Veterans+Health+Administration&rft.au=Hicken%2C+Bret+L%3BPlowhead%2C+Angela&rft.aulast=Hicken&rft.aufirst=Bret&rft.date=2010-08-01&rft.volume=41&rft.issue=4&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=Professional+Psychology%3A+Research+and+Practice&rft.issn=07357028&rft_id=info:doi/10.1037%2Fa0020431 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Psychologists; Home based; Military hospitals; Health; Psychology; Underserved people; Confidentiality; Confusion; Mental health services DO - http://dx.doi.org/10.1037/a0020431 ER - TY - JOUR T1 - Rapid identification of bla sub(KPC)-possessing Enterobacteriaceae by PCR/electrospray ionization-mass spectrometry AN - 754884526; 13440149 JF - Journal of Antimicrobial Chemotherapy AU - Endimiani, Andrea AU - Hujer, Kristine M AU - Hujer, Andrea M AU - Sampath, Rangarajan AU - Ecker, David J AU - Bonomo, Robert A Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1833 EP - 1834 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 65 IS - 8 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - KPC KW - carbapenemases KW - T5000 KW - PCR/ESI-MS KW - K. pneumoniae KW - Polymerase chain reaction KW - Enterobacteriaceae KW - Spectrometry KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754884526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Rapid+identification+of+bla+sub%28KPC%29-possessing+Enterobacteriaceae+by+PCR%2Felectrospray+ionization-mass+spectrometry&rft.au=Endimiani%2C+Andrea%3BHujer%2C+Kristine+M%3BHujer%2C+Andrea+M%3BSampath%2C+Rangarajan%3BEcker%2C+David+J%3BBonomo%2C+Robert+A&rft.aulast=Endimiani&rft.aufirst=Andrea&rft.date=2010-08-01&rft.volume=65&rft.issue=8&rft.spage=1833&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkq207 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Polymerase chain reaction; Spectrometry; Enterobacteriaceae DO - http://dx.doi.org/10.1093/jac/dkq207 ER - TY - JOUR T1 - Carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae across a hospital system: impact of post-acute care facilities on dissemination AN - 754883040; 13440148 AB - Background Resistance to carbapenems among Acinetobacter baumannii and Klebsiella pneumoniae presents a serious therapeutic and infection control challenge. We describe the epidemiology and genetic basis of carbapenem resistance in A. baumannii and K. pneumoniae in a six-hospital healthcare system in Northeast Ohio. Methods Clinical isolates of A. baumannii and K. pneumoniae distributed across the healthcare system were collected from April 2007 to April 2008. Antimicrobial susceptibility testing was performed followed by molecular analysis of carbapenemase genes. Genetic relatedness of isolates was established with repetitive sequence-based PCR (rep-PCR), multilocus PCR followed by electrospray ionization mass spectrometry (PCR/ESI-MS) and PFGE. Clinical characteristics and outcomes of patients were reviewed. Results Among 39 isolates of A. baumannii, two predominant genotypes related to European clone II were found. Eighteen isolates contained bla sub(OXA-23), and four isolates possessed bla sub(OXA-24/40). Among 29 K. pneumoniae isolates with decreased susceptibility to carbapenems, two distinct genotypes containing bla sub(KPC-2) or bla sub(KPC-3) were found. Patients with carbapenem-resistant A. baumannii and K. pneumoniae were elderly, possessed multiple co-morbidities, were frequently admitted from and discharged to post-acute care facilities, and experienced prolonged hospital stays (up to 25 days) with a high mortality rate (up to 35%). Conclusion In this outbreak of carbapenem-resistant A. baumannii and K. pneumoniae across a healthcare system, we illustrate the important role post-acute care facilities play in the dissemination of multidrug-resistant phenotypes. JF - Journal of Antimicrobial Chemotherapy AU - Perez, Federico AU - Endimiani, Andrea AU - Ray, Amy J AU - Decker, Brooke K AU - Wallace, Christopher J AU - Hujer, Kristine M AU - Ecker, David J AU - Adams, Mark D AU - Toltzis, Philip AU - Dul, Michael J AU - Windau, Anne AU - Bajaksouzian, Saralee AU - Jacobs, Michael R AU - Salata, Robert A AU - Bonomo, Robert A Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1807 EP - 1818 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 65 IS - 8 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clinical isolates KW - Mortality KW - Drug resistance KW - Carbapenems KW - carbapenemase KW - Genotypes KW - Infection KW - Mass spectroscopy KW - Antimicrobial agents KW - Acinetobacter baumannii KW - Epidemiology KW - Geriatrics KW - Polymerase chain reaction KW - Klebsiella pneumoniae KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754883040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Carbapenem-resistant+Acinetobacter+baumannii+and+Klebsiella+pneumoniae+across+a+hospital+system%3A+impact+of+post-acute+care+facilities+on+dissemination&rft.au=Perez%2C+Federico%3BEndimiani%2C+Andrea%3BRay%2C+Amy+J%3BDecker%2C+Brooke+K%3BWallace%2C+Christopher+J%3BHujer%2C+Kristine+M%3BEcker%2C+David+J%3BAdams%2C+Mark+D%3BToltzis%2C+Philip%3BDul%2C+Michael+J%3BWindau%2C+Anne%3BBajaksouzian%2C+Saralee%3BJacobs%2C+Michael+R%3BSalata%2C+Robert+A%3BBonomo%2C+Robert+A&rft.aulast=Perez&rft.aufirst=Federico&rft.date=2010-08-01&rft.volume=65&rft.issue=8&rft.spage=1807&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkq191 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Mortality; Drug resistance; Carbapenems; carbapenemase; Genotypes; Infection; Mass spectroscopy; Antimicrobial agents; Epidemiology; Geriatrics; Polymerase chain reaction; Hospitals; Acinetobacter baumannii; Klebsiella pneumoniae DO - http://dx.doi.org/10.1093/jac/dkq191 ER - TY - JOUR T1 - Prevalence and Characteristics of Tinnitus among US Adults AN - 754564784; 13405577 AB - Tinnitus is common; however, few risk factors for tinnitus are known. Methods - We examined cross-sectional relations between several potential risk factors and self-reported tinnitus in 14,178 participants in the 1999-2004 National Health and Nutrition Examination Surveys, a nationally representative database. We calculated the prevalence of any and frequent (at least daily) tinnitus in the overall US population and among subgroups. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) after adjusting for multiple potential confounders. Results - Approximately 50 million US adults reported having any tinnitus, and 16 million US adults reported having frequent tinnitus in the past year. The prevalence of frequent tinnitus increased with increasing age, peaking at 14.3% between 60 and 69 years of age. Non-Hispanic whites had higher odds of frequent tinnitus compared with other racial/ethnic groups. Hypertension and former smoking were associated with an increase in odds of frequent tinnitus. Loud leisure-time, firearm, and occupational noise exposure also were associated with increased odds of frequent tinnitus. Among participants who had an audiogram, frequent tinnitus was associated with low-mid frequency (OR 2.37; 95% CI, 1.76-3.21) and high frequency (OR 3.00; 95% CI, 1.78-5.04) hearing impairment. Among participants who were tested for mental health conditions, frequent tinnitus was associated with generalized anxiety disorder (OR 6.07; 95% CI, 2.33-15.78) but not major depressive disorder (OR 1.58; 95% CI, 0.54-4.62). Conclusions - The prevalence of frequent tinnitus is highest among older adults, non-Hispanic whites, former smokers, and adults with hypertension, hearing impairment, loud noise exposure, or generalized anxiety disorder. Prospective studies of risk factors for tinnitus are needed. JF - American Journal of Medicine AU - Shargorodsky, Josef AU - Curhan, Gary C AU - Farwell, Wildon R AD - Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, wildon.farwell@va.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 711 EP - 718 PB - Elsevier BV, PO Box 10670 Riverton, NJ 08076 USA VL - 123 IS - 8 SN - 0002-9343, 0002-9343 KW - Risk Abstracts KW - Age KW - USA KW - Noise levels KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754564784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Medicine&rft.atitle=Prevalence+and+Characteristics+of+Tinnitus+among+US+Adults&rft.au=Shargorodsky%2C+Josef%3BCurhan%2C+Gary+C%3BFarwell%2C+Wildon+R&rft.aulast=Shargorodsky&rft.aufirst=Josef&rft.date=2010-08-01&rft.volume=123&rft.issue=8&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Medicine&rft.issn=00029343&rft_id=info:doi/10.1016%2Fj.amjmed.2010.02.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Noise levels; USA DO - http://dx.doi.org/10.1016/j.amjmed.2010.02.015 ER - TY - JOUR T1 - Mindfulness and acceptance are associated with exercise maintenance in YMCA exercisers AN - 754144125; 201027033 AB - Although most U.S. adults have initiated an exercise program at some time, only a fraction are able to maintain consistent exercise. Instead, research suggests that intermittent exercise is commonplace among U.S. adults, underscoring the importance of identifying factors associated with consistent exercise at a level that promotes health and long-term maintenance of this activity. We proposed a theoretical model in which mindfulness and acceptance may promote exercise initiation and maintenance. Mindfulness, acceptance, and suppression were examined as a function of exercise status in 266 YMCA exercisers. Those who were successful at maintaining exercise tended to score higher on measures of mindfulness and acceptance, and lower on measures of suppression. Findings are discussed in light of our proposed theoretical model in which exercisers having greater mindfulness and acceptance are less reactive; responding with more balanced appraisals to threats to their exercise regimen which in turn promotes increased exercise maintenance. Future studies should utilize longitudinal design to examine causal relationships between variables. [Copyright Elsevier Ltd.] JF - Behaviour Research and Therapy AU - Ulmer, Christi S AU - Stetson, Barbara A AU - Salmon, Paul G AD - Department of Psychological and Brain Science, 317 Life Sciences Building, University of Louisville, Louisville, KY 40292, USA christi.ulmer@va.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 805 EP - 809 PB - Elsevier, Amsterdam The Netherlands VL - 48 IS - 8 SN - 0005-7967, 0005-7967 KW - Exercise Adherence Mindfulness Acceptance Suppression Physical activity KW - Acceptance KW - Medical research KW - Awareness KW - Exercise KW - Suppression KW - Health promotion KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754144125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behaviour+Research+and+Therapy&rft.atitle=Mindfulness+and+acceptance+are+associated+with+exercise+maintenance+in+YMCA+exercisers&rft.au=Ulmer%2C+Christi+S%3BStetson%2C+Barbara+A%3BSalmon%2C+Paul+G&rft.aulast=Ulmer&rft.aufirst=Christi&rft.date=2010-08-01&rft.volume=48&rft.issue=8&rft.spage=805&rft.isbn=&rft.btitle=&rft.title=Behaviour+Research+and+Therapy&rft.issn=00057967&rft_id=info:doi/10.1016%2Fj.brat.2010.04.009 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-09-10 N1 - Last updated - 2016-09-27 N1 - CODEN - BRTHAA N1 - SubjectsTermNotLitGenreText - Exercise; Awareness; Acceptance; Suppression; Health promotion; Medical research DO - http://dx.doi.org/10.1016/j.brat.2010.04.009 ER - TY - JOUR T1 - Responding to Symptoms of Alzheimer's Disease: Husbands, Wives, and the Gendered Dynamics of Recognition and Disclosure AN - 754136496; 201021397 AB - In this article, we analyze the process of redefining marital relations within the context of couples dealing with Alzheimer's disease and related disorders (ADRDs), drawing on intensive interviews with 13 caregiver husbands and 15 caregiver wives. Men were slower to recognize the symptoms of ADRDs, with social others usually bringing the problems to their attention. They often attributed symptoms to a less-problematic cause and engaged in extended normalization of their wife's condition. Women were quicker to recognize symptoms and often noticed subtle changes in their husbands but failed to take action quickly. They were reluctant to disclose their concerns to their impaired husbands, which might have protected the husband's masculine identity and served to maintain the wife's own sense of self in relation to him. We suggest that husbands were able to normalize because the wife's symptoms did not change marital authority dynamics, but authority relations were reversed by the illness for caregiver wives. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Qualitative Health Research AU - Hayes, Jeanne AU - Zimmerman, Mary K AU - Boylstein, Craig AD - Kansas City VA Medical Center, Kansas City, Missouri, USA jeanne.hayes@va.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 1101 EP - 1115 PB - Sage Publications, Thousand Oaks CA VL - 20 IS - 8 SN - 1049-7323, 1049-7323 KW - Alzheimer's disease gender health behavior illness and disease information threatening interpretive methods interviews unstructured relationships primary partner KW - Symptoms KW - Authority KW - Alzheimer's disease KW - Married couples KW - Sense of self KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754136496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Qualitative+Health+Research&rft.atitle=Responding+to+Symptoms+of+Alzheimer%27s+Disease%3A+Husbands%2C+Wives%2C+and+the+Gendered+Dynamics+of+Recognition+and+Disclosure&rft.au=Hayes%2C+Jeanne%3BZimmerman%2C+Mary+K%3BBoylstein%2C+Craig&rft.aulast=Hayes&rft.aufirst=Jeanne&rft.date=2010-08-01&rft.volume=20&rft.issue=8&rft.spage=1101&rft.isbn=&rft.btitle=&rft.title=Qualitative+Health+Research&rft.issn=10497323&rft_id=info:doi/10.1177%2F1049732310369559 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - QHREEM N1 - SubjectsTermNotLitGenreText - Married couples; Symptoms; Carers; Alzheimer's disease; Authority; Sense of self DO - http://dx.doi.org/10.1177/1049732310369559 ER - TY - JOUR T1 - Care Management's Challenges and Opportunities to Reduce the Rapid Rehospitalization of Frail Community-Dwelling Older Adults AN - 754040996; 201052090 AB - Community-based frail older adults, burdened with complex medical and social needs, are at great risk for preventable rapid rehospitalizations. Although federal and state regulations are in place to address the care transitions between the hospital and nursing home, no such guidelines exist for the much larger population of community-dwelling frail older adults. Few studies have looked at interventions to prevent rehospitalizations in this large segment of the older adult population. Similarly, standardized disease management approaches that lower hospitalization rates in an independent adult population may not suffice for guiding the care of frail persons. Care management interventions currently face unique challenges in their attempt to improve the transitional care of community-dwelling older adults. However, impending national imperatives aimed at reducing potentially avoidable hospitalizations will soon demand and reward care management strategies that identify frail persons early in the discharge process and promote the sharing of critical information among patients, caregivers, and health care professionals. Opportunities to improve the quality and efficiency of care-related communications must focus on the effective blending of training and technology for improving communications vital to successful care transitions. Adapted from the source document. JF - The Gerontologist AU - Golden, Adam G AU - Tewary, Sweta AU - Dang, Stuti AU - Roos, Bernard A AD - Geriatric Research, Education, and Clinical Center (11GRC), 1201 NW 16 Street, Miami, FL 33125 adam.golden@va.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 451 EP - 458 PB - Gerontological Society of America, Washington DC VL - 50 IS - 4 SN - 0016-9013, 0016-9013 KW - Care coordination, Medicaid waiver, Homebound, Medicaid, Rehospitalization KW - Handicapped KW - Management KW - Quality of Health Care KW - Information Dissemination KW - Communication KW - Elderly KW - Intervention KW - Diseases KW - Technology KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754040996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=Care+Management%27s+Challenges+and+Opportunities+to+Reduce+the+Rapid+Rehospitalization+of+Frail+Community-Dwelling+Older+Adults&rft.au=Golden%2C+Adam+G%3BTewary%2C+Sweta%3BDang%2C+Stuti%3BRoos%2C+Bernard+A&rft.aulast=Golden&rft.aufirst=Adam&rft.date=2010-08-01&rft.volume=50&rft.issue=4&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/10.1093%2Fgeront%2Fgnq015 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-08-09 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Elderly; Handicapped; Management; Intervention; Information Dissemination; Quality of Health Care; Technology; Diseases; Communication DO - http://dx.doi.org/10.1093/geront/gnq015 ER - TY - JOUR T1 - Antiretroviral therapy and management of HIV infection AN - 754567035; 13406650 AB - Antiretroviral therapy of HIV infection has changed a uniformly fatal into a potentially chronic disease. There are now 17 drugs in common use for HIV treatment. Patients who can access and adhere to combination therapy should be able to achieve durable, potentially lifelong suppression of HIV replication. Despite the unquestioned success of antiretroviral therapy, limitations persist. Treatment success needs strict lifelong drug adherence. Although the widely used drugs are generally well tolerated, most have some short-term toxic effects and all have the potential for both known and unknown long-term toxic effects. Drug and administration costs limit treatment in resource-poor regions, and are a growing concern even in resource rich settings. Finally, complete or near complete control of viral replication does not fully restore health. Long-term treated patients who are on an otherwise effective regimen often show persistent immune dysfunction and have higher than expected risk for various non-AIDS-related complications, including heart, bone, liver, kidney, and neurocognitive diseases. JF - Lancet AU - Volberding, Paul A AU - Deeks, Steven G AD - Department of Medicine, University of California San Francisco, San Francisco, CA, USA, paul.volberding@va.gov Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 SP - 49 EP - 62 PB - The Lancet Ltd., 655 Ave. of the Americas New York NY 10011 USA VL - 376 IS - 9734 SN - 0140-6736, 0140-6736 KW - Risk Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Bone KW - Human immunodeficiency virus KW - antiretroviral therapy KW - V 22360:AIDS and HIV KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754567035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Antiretroviral+therapy+and+management+of+HIV+infection&rft.au=Volberding%2C+Paul+A%3BDeeks%2C+Steven+G&rft.aulast=Volberding&rft.aufirst=Paul&rft.date=2010-07-03&rft.volume=376&rft.issue=9734&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2810%2960676-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - antiretroviral therapy; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/S0140-6736(10)60676-9 ER - TY - JOUR T1 - A Novel Use for Real Time Locating Systems: Discrete Event Simulation Validation in Medical Systems AN - 875712638; 201112920 AB - In 2009, the St. Louis Veterans Affairs Medical Center (VAMC) installed a Real Time Locating system (RTLS) in their eye clinic. The system tracks staff and patient movement through a combination of radio-frequency identification and infra-red technology. This system, in addition to its primary purpose as a throughput monitoring system, was used to gather data for the validation of a Discrete Event Simulation (DES) of the eye clinic. Use of the RTLS gathered data greatly diminished the time required to validate the simulation, as well as the cost of labor needed to observe and record the data points necessary. RTLS systems may be employed by operations researchers and systems engineers to assist in patient flow analysis in capacities beyond the 'Real Time' aspects of the locating system. Adapted from the source document. JF - International Journal of Healthcare Delivery Reform Initiatives AU - Day, T Eugene AU - Mehrotra, Anchit AU - Ravi, Nathan AD - St. Louis Veterans Administration Medical Center, USA Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 11 EP - 19 PB - IGI Global, Hershey, PA VL - 2 IS - 3 SN - 1938-0216, 1938-0216 KW - Discrete Event Simulation, Healthcare Delivery, Radio-Frequency Identification, Real Time Locating Systems, Technology Integration KW - Engineers KW - Simulation KW - St Louis KW - Clinics KW - Identification KW - Validation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875712638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Healthcare+Delivery+Reform+Initiatives&rft.atitle=A+Novel+Use+for+Real+Time+Locating+Systems%3A+Discrete+Event+Simulation+Validation+in+Medical+Systems&rft.au=Day%2C+T+Eugene%3BMehrotra%2C+Anchit%3BRavi%2C+Nathan&rft.aulast=Day&rft.aufirst=T&rft.date=2010-07-01&rft.volume=2&rft.issue=3&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Healthcare+Delivery+Reform+Initiatives&rft.issn=19380216&rft_id=info:doi/10.4018%2Fjhdri.2010070102 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-07-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Simulation; Clinics; Validation; Engineers; Identification; St Louis DO - http://dx.doi.org/10.4018/jhdri.2010070102 ER - TY - JOUR T1 - Future Directions in Surface Electromyography AN - 862593944; 201108697 AB - The use of surface electromyography (SEMG) has increased exponentially in the past four decades. SEMG is one of the most widespread measures employed today in psychophysiological assessment and one of three primary biofeedback modalities. This article briefly outlines three areas that the author believes are important for SEMG to address if it is to continue to flourish in the future: applications in telehealth, the use of telemetry and ambulatory monitoring, and studies on the stability or reliability of surface electromyography. Adapted from the source document. JF - Biofeedback AU - Arena, John G AD - Mental Health and Behavioral Sciences Service Line (269A), Department of Veterans Affairs Medical Center, Augusta, GA 30904-6284 john.arena@va.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 78 EP - 82 PB - Allen Press, Lawrence KS VL - 38 IS - 2 SN - 1081-5937, 1081-5937 KW - surface electromyography, psychophysiological assessment, telehealth, ambulatory monitoring, reliability of surface EMG KW - Assessment KW - Biofeedback KW - Reliability KW - Psychophysiological aspects KW - Electromyography KW - Monitoring KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862593944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biofeedback&rft.atitle=Future+Directions+in+Surface+Electromyography&rft.au=Arena%2C+John+G&rft.aulast=Arena&rft.aufirst=John&rft.date=2010-07-01&rft.volume=38&rft.issue=2&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Biofeedback&rft.issn=10815937&rft_id=info:doi/10.5298%2F1081-5937-38.2.78 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Electromyography; Biofeedback; Assessment; Psychophysiological aspects; Monitoring; Reliability DO - http://dx.doi.org/10.5298/1081-5937-38.2.78 ER - TY - JOUR T1 - Physical Health and Depression: A Dyadic Study of Chronic Health Conditions and Depressive Symptomatology in Older Adult Couples AN - 839576909; 201100168 AB - This study examined the associations among chronic health conditions, sociodemographic factors, and depressive symptomatology in older married couples. Data from the 2004 wave of the Health and Retirement Study (n = 2,184 couples) were analyzed. Results indicated a reciprocal relationship in depressive symptoms between spouses. Additionally, post hoc analyses indicated that husbands' stroke and high blood pressure were related to increased depressive symptomatology among wives. Beyond the reciprocal relationship, husbands were unaffected by wives' health. These results suggest sex differences underlying psychological distress in the context of physical health among older adults and that older women with husbands who have high levels of depressive symptomatology, high blood pressure, or a history of stroke may be at particular risk of experiencing depressive symptoms. Adapted from the source document. JF - Journals of Gerontology Series B: Psychological Sciences and Social Sciences AU - Ayotte, Brian J AU - Yang, Frances M AU - Jones, Richard N AD - Dept Psychology, U Massachusetts Dartmouth brian.ayotte@va.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 438 EP - 448 PB - Gerontological Society of America, Washington DC VL - 65B IS - 4 SN - 1079-5014, 1079-5014 KW - Depression KW - Married couples KW - Strokes KW - Health status KW - Health KW - Hypertension KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839576909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journals+of+Gerontology+Series+B%3A+Psychological+Sciences+and+Social+Sciences&rft.atitle=Physical+Health+and+Depression%3A+A+Dyadic+Study+of+Chronic+Health+Conditions+and+Depressive+Symptomatology+in+Older+Adult+Couples&rft.au=Ayotte%2C+Brian+J%3BYang%2C+Frances+M%3BJones%2C+Richard+N&rft.aulast=Ayotte&rft.aufirst=Brian&rft.date=2010-07-01&rft.volume=65B&rft.issue=4&rft.spage=438&rft.isbn=&rft.btitle=&rft.title=Journals+of+Gerontology+Series+B%3A+Psychological+Sciences+and+Social+Sciences&rft.issn=10795014&rft_id=info:doi/10.1093%2Fgeronb%2Fgbq033 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JGBSF3 N1 - SubjectsTermNotLitGenreText - Depression; Married couples; Hypertension; Health status; Health; Strokes DO - http://dx.doi.org/10.1093/geronb/gbq033 ER - TY - JOUR T1 - The Relation Between Social Identity Integration and Psychological Adjustment: A Focus on Mainstream and Marginalized Cultural Identities AN - 758125061; 201057262 AB - The authors examined the association between social identity integration and psychological adjustment in a mainstream sample of Latter-Day Saints (Study 1) and a marginalized sample of gay men (Study 2). Results across both samples indicated that psychological adjustment was significantly and positively associated with social identity integration. Exploratory analyses revealed that for the Study 1 sample, the relation between integration and adjustment was largely explained by individuals' feelings of authenticity. Results for the gay male sample showed the relation between integration and adjustment was explained less by authenticity; instead, perceptions of social identity negativity appeared to play a mediating role. The authors discuss the implications for research on identity development and dealing with devalued group memberships. Adapted from the source document. JF - Identity: An International Journal of Theory and Research AU - Tragakis, Michael W AU - Smith, Jessi L AD - Veterans Administration Salt Lake City Health Care System Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 201 EP - 221 PB - Taylor & Francis, Philadelphia PA VL - 10 IS - 3 SN - 1528-3488, 1528-3488 KW - Social Identity KW - Males KW - Membership KW - Research and Development KW - Homosexuality KW - Social Integration KW - Marginality KW - Cultural Identity KW - Adjustment KW - article KW - 0513: culture and social structure; culture (kinship, forms of social organization, social cohesion & integration, & social representations) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758125061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Identity%3A+An+International+Journal+of+Theory+and+Research&rft.atitle=The+Relation+Between+Social+Identity+Integration+and+Psychological+Adjustment%3A+A+Focus+on+Mainstream+and+Marginalized+Cultural+Identities&rft.au=Tragakis%2C+Michael+W%3BSmith%2C+Jessi+L&rft.aulast=Tragakis&rft.aufirst=Michael&rft.date=2010-07-01&rft.volume=10&rft.issue=3&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Identity%3A+An+International+Journal+of+Theory+and+Research&rft.issn=15283488&rft_id=info:doi/10.1080%2F15283488.2010.495909 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-12 N1 - Number of references - 59 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social Integration; Adjustment; Social Identity; Homosexuality; Marginality; Research and Development; Membership; Cultural Identity; Males DO - http://dx.doi.org/10.1080/15283488.2010.495909 ER - TY - JOUR T1 - Privatizing Defense Support Operations: The Need to Improve DoD's Oversight and Management AN - 758118709; 2010-596486 AB - The Department of Defense (DoD) has contracted defense support operations to private U.S. and foreign firms in an ever-increasing manner in both Iraq and Afghanistan. Significant factors that have contributed to this outsourcing include the proliferation of military operations, the increased sophistication of U.S. weapons systems used in these operations, and a reduction in the size of the U.S. military after the breakup of the former Soviet Union. The concerns raised with this process have centered on contract management and oversight. Despite the fact that DoD has continually updated its written guidance to defense officials charged with oversight of contractor performance, DoD has faced continuing problems related to a lack of visibility over the totality of contractor support at deployed locations, a lack of adequate contract oversight personnel, and the failure to collect and share institutional knowledge on the use of certain contractors. [Reprinted by permission; copyright Inter-University Seminar on Armed Forces and Society/Sage Publications Inc.] JF - Armed Forces & Society AU - Terry, James P AD - Department of Veterans Affairs, Washington, DC james.terry2@va.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 660 EP - 670 PB - Sage Publications, Thousand Oaks CA VL - 36 IS - 4 SN - 0095-327X, 0095-327X KW - Business and service sector - Business organization and administration KW - Manufacturing and heavy industry - Industrial management, production, and productivity KW - Economic conditions and policy - Economic policy, planning, and development KW - Military and defense policy - Military policy KW - Law and ethics - Criminal law KW - Government - Internal security KW - Manufacturing and heavy industry - Building and construction KW - Military and defense policy - Military planning, strategy, and operations KW - outsourcing privatization defense contracting contract oversight KW - Defense contracts KW - Outsourcing KW - Military operations KW - Privatization KW - Contractors KW - Afghanistan KW - Iraq KW - United States Defense department KW - Surveillance KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758118709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Armed+Forces+%26+Society&rft.atitle=Privatizing+Defense+Support+Operations%3A+The+Need+to+Improve+DoD%27s+Oversight+and+Management&rft.au=Terry%2C+James+P&rft.aulast=Terry&rft.aufirst=James&rft.date=2010-07-01&rft.volume=36&rft.issue=4&rft.spage=660&rft.isbn=&rft.btitle=&rft.title=Armed+Forces+%26+Society&rft.issn=0095327X&rft_id=info:doi/10.1177%2F0095327X10361669 LA - English DB - PAIS Index N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - CODEN - AFSOD2 N1 - SubjectsTermNotLitGenreText - Outsourcing; Privatization; Defense contracts; Surveillance; United States Defense department; Contractors; Iraq; Afghanistan; Military operations DO - http://dx.doi.org/10.1177/0095327X10361669 ER - TY - JOUR T1 - Use of Psychotherapy by Rural and Urban Veterans AN - 754878649; 13377516 AB - Purpose: To examine whether differences exist between rural and urban veterans in terms of initiation of psychotherapy, delay in time from diagnosis to treatment, and dose of psychotherapy sessions. Methods: Using a longitudinal cohort of veterans obtained from national Veterans Affairs databases (October 2003 through September 2004), we extracted veterans with a new diagnosis of depression, anxiety, or posttraumatic stress disorder (PTSD) (n = 410,923). Veterans were classified as rural (categories 6-9; n = 65,044) or urban (category 1; n = 149,747), using the US Department of Agriculture Rural-Urban Continuum Codes. Psychotherapy encounters were identified using Current Procedural Terminology codes for the 12 months following patients' initial diagnosis. Findings: Newly diagnosed rural veterans were significantly less likely (P < .0001) to receive psychotherapy (both individual and group). Urban veterans were roughly twice as likely as rural veterans to receive 4 or more (9.46% vs 5.08%) and 8 or more (5.59% vs 2.35%) psychotherapy sessions (P < .001). Conclusions: Rural veterans are significantly less likely to receive psychotherapy services, and the dose of the psychotherapy services provided for rural veterans is limited relative to their urban counterparts. Focused efforts are needed to increase access to psychotherapy services provided to rural veterans with depression, anxiety, and PTSD. JF - Journal of Rural Health AU - Cully, Jeffrey A AU - Jameson, John P AU - Phillips, Laura L AU - Kunik, Mark E AU - Fortney, John C AD - Houston Center for Quality of Care & Utilization Studies, Veterans Affairs Health Services Research and Development Center (HSR&D) of Excellence, Houston, Texas., Jeffrey.Cully@va.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 225 EP - 233 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 26 IS - 3 SN - 0890-765X, 0890-765X KW - Health & Safety Science Abstracts KW - posttraumatic stress disorder KW - Psychology KW - agriculture KW - depression KW - Rural areas KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754878649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rural+Health&rft.atitle=Use+of+Psychotherapy+by+Rural+and+Urban+Veterans&rft.au=Cully%2C+Jeffrey+A%3BJameson%2C+John+P%3BPhillips%2C+Laura+L%3BKunik%2C+Mark+E%3BFortney%2C+John+C&rft.aulast=Cully&rft.aufirst=Jeffrey&rft.date=2010-07-01&rft.volume=26&rft.issue=3&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2010.00294.x L2 - http://www3.interscience.wiley.com/journal/123432135/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - posttraumatic stress disorder; Psychology; agriculture; depression; Rural areas DO - http://dx.doi.org/10.1111/j.1748-0361.2010.00294.x ER - TY - JOUR T1 - Evaluation of a Commercial Microarray System for Detection of SHV-, TEM-, CTX-M-, and KPC-Type b-Lactamase Genes in Gram-Negative Isolates AN - 754868596; 13209882 AB - We evaluated the ability of a commercial microarray system (Check KPC/ESBL; Check-Points Health BV) to detect clinically important class A ?-lactamase genes. A total of 106 Gram-negative strains were tested. The following sensitivity and specificity results were recorded, respectively: for blaSHV, 98.8% and 100%; for blaTEM, 100% and 96.4%; and for blaCTX-M and blaKPC, 100% and 100%. JF - Journal of Clinical Microbiology AU - Endimiani, Andrea AU - Hujer, Andrea M AU - Hujer, Kristine M AU - Gatta, Julian A AU - Schriver, Andrew C AU - Jacobs, Michael R AU - Rice, Louis B AU - Bonomo, Robert A AD - Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, robert.bonomo@va.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 2618 EP - 2622 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 48 IS - 7 SN - 0095-1137, 0095-1137 KW - Bacteria KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - Assays KW - b-Lactamase KW - J 02310:Genetics & Taxonomy KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754868596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Evaluation+of+a+Commercial+Microarray+System+for+Detection+of+SHV-%2C+TEM-%2C+CTX-M-%2C+and+KPC-Type+b-Lactamase+Genes+in+Gram-Negative+Isolates&rft.au=Endimiani%2C+Andrea%3BHujer%2C+Andrea+M%3BHujer%2C+Kristine+M%3BGatta%2C+Julian+A%3BSchriver%2C+Andrew+C%3BJacobs%2C+Michael+R%3BRice%2C+Louis+B%3BBonomo%2C+Robert+A&rft.aulast=Endimiani&rft.aufirst=Andrea&rft.date=2010-07-01&rft.volume=48&rft.issue=7&rft.spage=2618&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00568-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Assays; b-Lactamase; Bacteria DO - http://dx.doi.org/10.1128/JCM.00568-10 ER - TY - JOUR T1 - RAGE and Abeta immunoglobulins: relation to Alzheimer's disease-related cognitive function. AN - 754147690; pmid-20441687 AB - The immunoglobulins (IgGs) for beta amyloid (Abeta) and receptors for the advanced glycation end products (RAGE) have previously been shown to be related to memory and language measures in a mixed neurological sample of older adults. In this study, we examined group differences in Abeta and RAGE IgGs, as well as the relationship between both IgGs and cognitive performance in nondiabetic older adults with normal cognition, mild cognitive impairment (MCI), and probable Alzheimer's disease (AD). We found RAGE and Abeta levels to be elevated in some AD participants, leading to significant AD-control group differences. While there was an overall correlation between both IgG levels and global cognition across all three groups, this relationship was largely attributable to group differences in cognition, highlighted by considerable variability within groups in the relationship between IgG levels and cognition. While findings do not support a consistent relationship between cognition and either IgG, further research with larger samples is needed to better characterize cognitive differences between AD participants with high versus low Abeta and RAGE titers. JF - Journal of the International Neuropsychological Society : JINS AU - Mitchell, Meghan B AU - Buccafusco, Jerry J AU - Schade, Rosann F AU - Webster, Scott J AU - Mruthinti, Shyamala AU - Harrell, Dean U AU - Gulati, Nidhi K AU - Miller, L Stephen AD - Department of Psychology, University of Georgia, Athens, Georgia, USA. Meghan.Mitchell2@va.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 672 EP - 678 VL - 16 IS - 4 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754147690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=RAGE+and+Abeta+immunoglobulins%3A+relation+to+Alzheimer%27s+disease-related+cognitive+function.&rft.au=Mitchell%2C+Meghan+B%3BBuccafusco%2C+Jerry+J%3BSchade%2C+Rosann+F%3BWebster%2C+Scott+J%3BMruthinti%2C+Shyamala%3BHarrell%2C+Dean+U%3BGulati%2C+Nidhi+K%3BMiller%2C+L+Stephen&rft.aulast=Mitchell&rft.aufirst=Meghan&rft.date=2010-07-01&rft.volume=16&rft.issue=4&rft.spage=672&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-06-28 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Recognizing and Managing Pyschogenic Polydipsia in Mental Health AN - 754140187; 201023803 AB - Psychogenic polydipsia (PPD) or water intoxication with polyuria and polydipsia is common among patients with psychiatric disorders. Although the underlying pathology is unclear, PPD or drinking more than 3 liters of fluid daily can be a highly disabling and life-threatening condition. In half of the cases, it can lead to mortality because of cerebral edema and central nervous system dysfunction with delirium, seizures, coma, and death. Excessive drinking can accompany other repetitive behaviors in schizophrenic, bipolar, or psychotic patients. A screening program can detect cases early to minimize morbidity and mortality. This article describes the evidence-based screening, evaluation, and management of water intoxication or polydipsia and includes a case study to illustrate evaluation and management. [Copyright Elsevier B.V.] JF - The Journal for Nurse Practitioners AU - Valente, Sharon AU - Fisher, Diane Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 546 EP - 550 PB - Elsevier Ltd, The Netherlands VL - 6 IS - 7 SN - 1555-4155, 1555-4155 KW - polydipsia psychogenic water intoxication KW - Screening KW - Central nervous system KW - Polydipsia KW - Psychoses KW - Water intoxication KW - Morbidity-Mortality KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754140187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+for+Nurse+Practitioners&rft.atitle=Recognizing+and+Managing+Pyschogenic+Polydipsia+in+Mental+Health&rft.au=Valente%2C+Sharon%3BFisher%2C+Diane&rft.aulast=Valente&rft.aufirst=Sharon&rft.date=2010-07-01&rft.volume=6&rft.issue=7&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=The+Journal+for+Nurse+Practitioners&rft.issn=15554155&rft_id=info:doi/10.1016%2Fj.nurpra.2010.03.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-08-09 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Polydipsia; Morbidity-Mortality; Water intoxication; Screening; Psychoses; Central nervous system DO - http://dx.doi.org/10.1016/j.nurpra.2010.03.004 ER - TY - JOUR T1 - The Electronic Medical Record: Optimizing Human not Computer Capabilities AN - 754138984; 201022219 AB - The widespread adoption of computerized medical records provides medical administrators and payers the means to promote more standardized and thorough medical records by insuring clinicians complete mandatory screens, history and physical templates, and formatted treatment plans. But there is a dearth of evidence that such measures, whether computerized or not, improve clinical outcomes and reason to suspect that they may impede care. While these measures maximize the computer's capabilities they are insensitive to human capabilities. A series of 'check-offs', 'fill-ins' and 'drop-downs' might facilitate quality assurance activities, but such standardized measures can interfere with the clinicians' processing of information into narrative structures that are necessary for memory and decision making. Computerization does not necessitate this standardization. The adoption of an electronic medical record could provide the opportunity to move beyond standardized measures that were developed to oversee written records and instead harness the computers' capabilities to promote the unique, specific, and narrative quality of the clinical encounter. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - Luchins, Daniel AD - Chief Mental Health Research, Jesse Brown VAMC, 820 S. Damen Ave. 116A, Chicago, IL, 60612, USA Daniel.luchins@va.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 375 EP - 378 PB - Springer, Dordrecht The Netherlands VL - 37 IS - 4 SN - 0894-587X, 0894-587X KW - Clinical outcomes KW - Computerized medical records KW - Quality assurance KW - Computers KW - Narratives KW - Capabilities KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754138984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=The+Electronic+Medical+Record%3A+Optimizing+Human+not+Computer+Capabilities&rft.au=Luchins%2C+Daniel&rft.aulast=Luchins&rft.aufirst=Daniel&rft.date=2010-07-01&rft.volume=37&rft.issue=4&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-009-0234-y LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Capabilities; Computerized medical records; Computers; Narratives; Clinical outcomes; Quality assurance DO - http://dx.doi.org/10.1007/s10488-009-0234-y ER - TY - JOUR T1 - Substrate Selectivity and a Novel Role in Inhibitor Discrimination by Residue 237 in the KPC-2 ?-Lactamase AN - 746011770; 13137242 AB - ?-Lactamase-mediated antibiotic resistance continues to challenge the contemporary treatment of serious bacterial infections. The KPC-2 ?-lactamase, a rapidly emerging Gram-negative resistance determinant, hydrolyzes all commercially available ?-lactams, including carbapenems and ?-lactamase inhibitors; the amino acid sequence requirements responsible for this versatility are not yet known. To explore the bases of ?-lactamase activity, we conducted site saturation mutagenesis at Ambler position 237. Only the T237S variant of the KPC-2 ?-lactamase expressed in Escherichia coli DH10B maintained MICs equivalent to those of the wild type (WT) against all of the ?-lactams tested, including carbapenems. In contrast, the T237A variant produced in E. coli DH10B exhibited elevated MICs for only ampicillin, piperacillin, and the ?-lactam-?-lactamase inhibitor combinations. Residue 237 also plays a novel role in inhibitor discrimination, as 11 of 19 variants exhibit a clavulanate-resistant, sulfone-susceptible phenotype. We further showed that the T237S variant displayed substrate kinetics similar to those of the WT KPC-2 enzyme. Consistent with susceptibility testing, the T237A variant demonstrated a lower kcat/Km for imipenem, cephalothin, and cefotaxime; interestingly, the most dramatic reduction was with cefotaxime. The decreases in catalytic efficiency were driven by both elevated Km values and decreased kcat values compared to those of the WT enzyme. Moreover, the T237A variant manifested increased Kis for clavulanic acid, sulbactam, and tazobactam, while the T237S variant displayed Kis similar to those of the WT. To explain these findings, a molecular model of T237A was constructed and this model suggested that (i) the hydroxyl side chain of T237 plays an important role in defining the substrate profile of the KPC-2 ?-lactamase and (ii) hydrogen bonding between the hydroxyl side chain of T237 and the sp2-hybridized carboxylate of imipenem may not readily occur in the T237A variant. This stringent requirement for selected cephalosporinase and carbapenemase activity and the important role of T237 in inhibitor discrimination in KPC-2 are central considerations in the future design of ?-lactam antibiotics and inhibitors. JF - Antimicrobial Agents & Chemotherapy AU - Papp-Wallace, Krisztina M AU - Taracila, Magdalena AU - Hornick, John M AU - Hujer, Andrea M AU - Hujer, Kristine M AU - Distler, Anne M AU - Endimiani, Andrea AU - Bonomo, Robert A AD - Departments of Medicine, robert.bonomo@med.va.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 2867 EP - 2877 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 7 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Molecular modelling KW - Cefotaxime KW - Carbapenems KW - Enzymes KW - Ampicillin KW - carbapenemase KW - Tazobactam KW - Antibiotics KW - Infection KW - Minimum inhibitory concentration KW - Imipenem KW - Sulbactam KW - saturation mutagenesis KW - Cephalosporinase KW - Cephalothin KW - Hydrogen bonding KW - Clavulanic acid KW - Kinetics KW - Escherichia coli KW - Piperacillin KW - Antibiotic resistance KW - Amino acid sequence KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746011770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Substrate+Selectivity+and+a+Novel+Role+in+Inhibitor+Discrimination+by+Residue+237+in+the+KPC-2+%3F-Lactamase&rft.au=Papp-Wallace%2C+Krisztina+M%3BTaracila%2C+Magdalena%3BHornick%2C+John+M%3BHujer%2C+Andrea+M%3BHujer%2C+Kristine+M%3BDistler%2C+Anne+M%3BEndimiani%2C+Andrea%3BBonomo%2C+Robert+A&rft.aulast=Papp-Wallace&rft.aufirst=Krisztina&rft.date=2010-07-01&rft.volume=54&rft.issue=7&rft.spage=2867&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00197-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Number of references - 59 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Cefotaxime; Ampicillin; Enzymes; Carbapenems; Antibiotics; Tazobactam; carbapenemase; Infection; Minimum inhibitory concentration; Sulbactam; Imipenem; saturation mutagenesis; Cephalosporinase; Cephalothin; Hydrogen bonding; Kinetics; Clavulanic acid; Piperacillin; Antibiotic resistance; Amino acid sequence; Escherichia coli DO - http://dx.doi.org/10.1128/AAC.00197-10 ER - TY - JOUR T1 - The Potential of Human Allogeneic Juvenile Chondrocytes for Restoration of Articular Cartilage AN - 744700535; 13188692 AB - Background: Donor-site morbidity, limited numbers of cells, loss of phenotype during ex vivo expansion, and age-related decline in chondrogenic activity present critical obstacles to the use of autologous chondrocyte implantation for cartilage repair. Chondrocytes from juvenile cadaveric donors may represent an alternative to autologous cells.Hypothesis/Purpose: The authors hypothesized that juvenile chondrocyte would show stronger and more stable chondrogenic activity than adult cells in vitro and that juvenile cells pose little risk of immunologic incompatibility in adult hosts.Study Design: Controlled laboratory study.Methods: Cartilage samples were from juvenile (13 years old) donors. The chondrogenic activity of freshly isolated human articular chondrocytes and of expanded cells after monolayer culture was measured by proteoglycan assay, gene expression analysis, and histology. Lymphocyte proliferation assays were used to assess immunogenic activity.Results: Proteoglycan content in neocartilage produced by juvenile chondrocytes was 100-fold higher than in neocartilage produced by adult cells. Collagen type II and type IX mRNA in fresh juvenile chondrocytes were 100- and 700-fold higher, respectively, than in adult chondrocytes. The distributions of collagens II and IX were similar in native juvenile cartilage and in neocartilage made by juvenile cells. Juvenile cells grew significantly faster in monolayer cultures than adult cells (P = .002) and proteoglycan levels produced in agarose culture was significantly higher in juvenile cells than in adult cells after multiple passages (P < .001). Juvenile chondrocytes did not stimulate lymphocyte proliferation.Conclusion: These results document a dramatic age-related decline in human chondrocyte chondrogenic potential and show that allogeneic juvenile chondrocytes do not stimulate an immunologic response in vivo.Clinical Relevance: Juvenile human chondrocytes have greater potential to restore articular cartilage than adult cells, and may be transplanted without the fear of rejection, suggesting a new allogeneic approach to restoring articular cartilage in older individuals. JF - American Journal of Sports Medicine AU - Adkisson, HDavis AU - Martin, James A AU - Amendola, Richard L AU - Milliman, Curt AU - Mauch, Kelsey A AU - Katwal, Arbindra B AU - Seyedin, Mitchell AU - Amendola, Annuziato AU - Streeter, Philip R AU - Buckwalter, Joseph A AD - University of Iowa Orthopaedics and Rehabilitation, Iowa City, Iowa, Iowa City Veterans Administration Medical Center, Iowa City, Iowa, Oregon Stem Cell Center, Center for Hematologic Malignancies, OHSU Knight Cancer Institute, Portland, Oregon, hadkisson@istotech.com Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1324 EP - 1333 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 7 SN - 0363-5465, 0363-5465 KW - Physical Education Index; Calcium & Calcified Tissue Abstracts KW - Measurement KW - Age KW - Donors KW - Culture KW - Fear KW - Cartilage KW - Chondrocytes KW - Cell culture KW - Lymphocytes KW - Adults KW - Morbidity KW - Gene expression KW - Cadavers KW - Organ transplants KW - Connective tissue KW - Cartilage (articular) KW - Youth KW - Autografts KW - Gerontology KW - Proteoglycans KW - Immunogenicity KW - Analysis KW - Collagen (type II) KW - Cell proliferation KW - Sports medicine KW - T 2030:Cartilage and Cartilage Diseases KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744700535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=The+Potential+of+Human+Allogeneic+Juvenile+Chondrocytes+for+Restoration+of+Articular+Cartilage&rft.au=Adkisson%2C+HDavis%3BMartin%2C+James+A%3BAmendola%2C+Richard+L%3BMilliman%2C+Curt%3BMauch%2C+Kelsey+A%3BKatwal%2C+Arbindra+B%3BSeyedin%2C+Mitchell%3BAmendola%2C+Annuziato%3BStreeter%2C+Philip+R%3BBuckwalter%2C+Joseph+A&rft.aulast=Adkisson&rft.aufirst=HDavis&rft.date=2010-07-01&rft.volume=38&rft.issue=7&rft.spage=1324&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F0363546510361950 LA - English DB - Physical Education Index N1 - Date revised - 2010-07-01 N1 - Number of references - 43 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Measurement; Culture; Fear; Analysis; Cartilage; Gerontology; Organ transplants; Connective tissue; Adults; Sports medicine; Youth; Autografts; Donors; Age; Chondrocytes; Cell culture; Lymphocytes; Morbidity; Proteoglycans; Gene expression; Immunogenicity; Cadavers; Collagen (type II); Cell proliferation; Cartilage (articular) DO - http://dx.doi.org/10.1177/0363546510361950 ER - TY - JOUR T1 - Students' functioning while studying abroad: The impact of psychological distress and loneliness AN - 743045329; 201043484 AB - Previous research has indicated that experiencing stress while traveling abroad is a rather common occurrence. Students studying abroad at Loyola University's Rome Center during the 2004 fall semester and the 2007 spring semester completed surveys, which examined aspects of psychological distress, loneliness, and functioning while abroad. These studies found that students experiencing more psychological distress and more loneliness demonstrated lower levels of functioning while studying abroad and this relationship was found at different time points in the semester. The results of this study should be reviewed by study abroad programs and used to enhance students' experiences while abroad by providing intercultural training and offering mental health resources for students abroad. [Copyright Elsevier Ltd.] JF - International Journal of Intercultural Relations AU - Hunley, Holly A AD - Loyola University Chicago, 1032 W. Sheridan Road, Chicago, IL 60660, USA Holly.Hunley@va.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 386 EP - 392 PB - Elsevier Science, Amsterdam The Netherlands VL - 34 IS - 4 SN - 0147-1767, 0147-1767 KW - Study abroad Psychological distress Loneliness Functioning KW - Foreign Students KW - Loneliness KW - Training KW - College Students KW - Stress KW - Psychological Distress KW - Mental Health KW - Students KW - article KW - 0513: culture and social structure; culture (kinship, forms of social organization, social cohesion & integration, & social representations) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743045329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Intercultural+Relations&rft.atitle=Students%27+functioning+while+studying+abroad%3A+The+impact+of+psychological+distress+and+loneliness&rft.au=Hunley%2C+Holly+A&rft.aulast=Hunley&rft.aufirst=Holly&rft.date=2010-07-01&rft.volume=34&rft.issue=4&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Intercultural+Relations&rft.issn=01471767&rft_id=info:doi/10.1016%2Fj.ijintrel.2009.08.005 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - CODEN - IRELDR N1 - SubjectsTermNotLitGenreText - Students; Loneliness; Psychological Distress; Training; Stress; College Students; Mental Health; Foreign Students DO - http://dx.doi.org/10.1016/j.ijintrel.2009.08.005 ER - TY - CPAPER T1 - Employee Gender, Generation, and Experience: Relationship to Workplace Climate Perceptions T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839634489; 5888906 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Osatuke, Katerine Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Sex KW - Perception KW - Climate KW - Personnel KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839634489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Employee+Gender%2C+Generation%2C+and+Experience%3A+Relationship+to+Workplace+Climate+Perceptions&rft.au=Osatuke%2C+Katerine&rft.aulast=Osatuke&rft.aufirst=Katerine&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=857&navItem LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - JOUR T1 - MURAMIC ACID, ENDOTOXIN, 3-HYDROXY FATTY ACIDS, AND ERGOSTEROL CONTENT EXPLAIN MONOCYTE AND EPITHELIAL CELL INFLAMMATORY RESPONSES TO AGRICULTURAL DUSTS AN - 746079368; 12920209 AB - In agricultural and other environments, inhalation of airborne microorganisms is linked to respiratory disease development Bacterial endotoxins, peptidoglycans, and fungi are potential causative agents, but relative microbial characterization and inflammatory comparisons amongst agricultural dusts are not well described. The aim of this study was to determine the distribution of microbial endotoxin, 3-hydroxy fatty acids (3-OHFA), muramic acid, and ergosterol and evaluate inflammatory responses in human monocytes and bronchial epithelial cells with various dust samples. Settled surface dust was obtained from five environments: swine facility, dairy barn, grain elevator, domestic home (no pets), and domestic home with dog. Endotoxin concentration was determined by recombinant factor C (rFC). 3-OHFA, muramic acid, and ergosterol were measured using gas chromatography-mass spectrometry. Dust-induced inflammatory cytokine secretion in human monocytes and bronchial epithelial cells was evaluated. Endotoxin-independent dust-induced inflammatory responses were evaluated. Endotoxin and 3-OHFA levels were highest in agricultural dusts. Muramic acid, endotoxin, 3-OHFA, and ergosterol were detected in dusts samples. Muramic acid was highest in animal farming dusts. Ergosterol was most significant in grain elevator dust. Agricultural dusts induced monocyte tumor necrosis factor (TNF) a, interleukin (IL)-6, IL-8, and epithelial cell IL-6 and IL-8 secretion. Monocyte and epithelial IL-6 and IL-8 secretion was not dependent on endotoxin. House dust(s) induced monocyte TNFa, IL-6, and IL-8 secretion. Swine facility dust generally produced elevated responses compared to other dusts. Agricultural dusts are complex with significant microbial component contribution. Large animal farming dust(s)-induced inflammation is not entirely dependent on endotoxin. Addition of muramic acid to endotoxin in large animal farming environment monitoring is warranted. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Poole, Jill A AU - Dooley, Gregory P AU - Saito, Rena AU - Burrell, Angela M AU - Bailey, Kristina L AU - Romberger, Debra J AU - Mehaffy, John AU - Reynolds, Stephen J AD - Omaha Veterans Administration Medical Center, Omaha, Nebraska Y1 - 2010/06/15/ PY - 2010 DA - 2010 Jun 15 SP - 684 EP - 700 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 73 IS - 7-12 SN - 1528-7394, 1528-7394 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Environment Abstracts; Toxicology Abstracts KW - Interleukin 6 KW - Endotoxins KW - Inhalation KW - Epithelial cells KW - Housing KW - Tumor necrosis factor KW - Airborne microorganisms KW - peptidoglycans KW - Respiratory diseases KW - Interleukin 8 KW - Dust KW - Mass spectroscopy KW - Pets KW - Gas chromatography KW - pets KW - Cytokines KW - Monocytes KW - Houses KW - Fungi KW - recombinant factor C KW - Tumor necrosis factor-a KW - Spectrometry KW - Inflammation KW - Dairies KW - Residential areas KW - Grain KW - Fatty acids KW - Ergosterol KW - K 03410:Animal Diseases KW - X 24370:Natural Toxins KW - F 06955:Immunomodulation & Immunopharmacology KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746079368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=MURAMIC+ACID%2C+ENDOTOXIN%2C+3-HYDROXY+FATTY+ACIDS%2C+AND+ERGOSTEROL+CONTENT+EXPLAIN+MONOCYTE+AND+EPITHELIAL+CELL+INFLAMMATORY+RESPONSES+TO+AGRICULTURAL+DUSTS&rft.au=Poole%2C+Jill+A%3BDooley%2C+Gregory+P%3BSaito%2C+Rena%3BBurrell%2C+Angela+M%3BBailey%2C+Kristina+L%3BRomberger%2C+Debra+J%3BMehaffy%2C+John%3BReynolds%2C+Stephen+J&rft.aulast=Poole&rft.aufirst=Jill&rft.date=2010-06-15&rft.volume=73&rft.issue=7-12&rft.spage=684&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390903578539 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Inhalation; Endotoxins; Interleukin 6; Epithelial cells; Houses; Fungi; Tumor necrosis factor; recombinant factor C; Airborne microorganisms; peptidoglycans; Tumor necrosis factor-a; Mass spectroscopy; Dust; Interleukin 8; Inflammation; Pets; Dairies; Gas chromatography; Fatty acids; Grain; Cytokines; Monocytes; Ergosterol; Housing; pets; Residential areas; Respiratory diseases; Spectrometry DO - http://dx.doi.org/10.1080/15287390903578539 ER - TY - JOUR T1 - Tinnitus onset rates from chemotherapeutic agents and ototoxic antibiotics: results of a large prospective study. AN - 853227490; pmid-20701838 AB - To report on the incidence and relative risk of tinnitus onset from a variety of drug therapies known to be ototoxic. Two main questions were asked: (1) What is the prevalence and incidence of tinnitus among patients treated with cisplatin, carboplatin, or ototoxic antibiotic therapies? (2) Do commonly reported treatment or subject factors confound or modify the incidence of tinnitus onset?A prospective observational study design was used to evaluate occurrence of significant otologic changes in 488 veterans (962 ears) receiving chemotherapeutic agents (cisplatin, carboplatin), ototoxic antibiotics (primarily aminoglycoside), or nonototoxic drugs (control medications). A subset of 260 veterans lacking tinnitus prior to drug exposure was used to compare rates of tinnitus onset. Subjects were tested prior to, during, and following their treatment. Planned comparisons using logistic regression, analysis of variance (ANOVA), and chi(2) statistics were made among groups by the type of medication taken, age, presence of preexisting hearing loss, days on drug, and cumulative dose of drug.Baseline tinnitus rates were high (nearly 47%) relative to the general population of a similar age. Subjects with exposure to ototoxic medications had significantly increased risk for developing tinnitus. Those on chemotherapeutic agents were found to have the greatest risk. Cisplatin elevated the risk by 5.53 times while carboplatin increased the risk by 3.75 over nonototoxic control medications. Ototoxic antibiotics resulted in borderline risk (2.81) for new tinnitus. Contrary to other reports, we did not find that subject factors (increased age or pre-existing hearing loss) or treatment factors (days on drug or cumulative dose) contributed to rates of tinnitus onset during treatment.This large prospective study confirms that new tinnitus during treatment is associated with chemotherapy and with certain ototoxic antibiotic treatment. Cisplatin and carboplatin were found to be the most potent ototoxic agents causing tinnitus at much greater numbers than the other drugs studied. Implications for counseling and audiological resource allocation are discussed.American Academy of Audiology. JF - Journal of the American Academy of Audiology AU - Dille, Marilyn F AU - Konrad-Martin, Dawn AU - Gallun, Frederick AU - Helt, Wendy J AU - Gordon, Jane S AU - Reavis, Kelly M AU - Bratt, Gene W AU - Fausti, Stephen A AD - VA RR & D National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Portland, OR 97239, USA. marilyn.dille@va.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 409 EP - 417 VL - 21 IS - 6 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Amikacin: toxicity KW - *Aminoglycosides: toxicity KW - *Anti-Bacterial Agents: toxicity KW - *Antineoplastic Agents: toxicity KW - Bacterial Infections: drug therapy KW - *Carboplatin: toxicity KW - *Cisplatin: toxicity KW - Cross-Sectional Studies KW - Female KW - Gentamicins: toxicity KW - Hearing Tests KW - Humans KW - Incidence KW - Male KW - Middle Aged KW - Neoplasms: drug therapy KW - Prospective Studies KW - Risk KW - Time Factors KW - *Tinnitus: chemically induced KW - Tinnitus: epidemiology KW - Tobramycin: toxicity KW - Vancomycin: toxicity KW - *Veterans: statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853227490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Tinnitus+onset+rates+from+chemotherapeutic+agents+and+ototoxic+antibiotics%3A+results+of+a+large+prospective+study.&rft.au=Dille%2C+Marilyn+F%3BKonrad-Martin%2C+Dawn%3BGallun%2C+Frederick%3BHelt%2C+Wendy+J%3BGordon%2C+Jane+S%3BReavis%2C+Kelly+M%3BBratt%2C+Gene+W%3BFausti%2C+Stephen+A&rft.aulast=Dille&rft.aufirst=Marilyn&rft.date=2010-06-01&rft.volume=21&rft.issue=6&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Effective rocker shapes used by able-bodied persons for walking and fore-aft swaying: Implications for design of ankle-foot prostheses AN - 754563092; 13399859 AB - The use of rocker models to understand functional tasks of the human lower limb is attractive because of their simplicity. Recent studies have determined a consistent feature of able-bodied walking termed the roll-over shape (ROS), which is the effective rocker shape that the lower limb system conforms to between initial contact and contralateral initial contact during walking. However, it is unclear what effective rocker shapes are used for fore-aft swaying. A better understanding of these shapes could be used to develop improved prostheses for this task, perhaps improving balance and balance confidence, and reducing the occurrence of falling in lower limb prosthesis users. We measured effective rocker shapes used by 11 able-bodied persons during walking and fore-aft swaying. We hypothesized that the curvature of the swaying shapes would be smaller (radius larger) than that of the walking shapes, providing a more stable interface with the ground during swaying. The radius (measured as the inverse of the curvature of the shape) was found to be about 1/3 of the leg length for walking, but over two times the leg length for swaying. A model examining the effective ankle stiffness necessary to achieve these curvatures suggests that the stiffness of a biomimetic prosthetic ankle would need to be over three times higher for fore-aft swaying than for walking. These results suggest that two separate modes would be needed in an ankle-foot prosthesis to mimic the physiologic system for walking and swaying. JF - Gait & Posture AU - Hansen, Andrew H AU - Wang, Charles C AD - Minneapolis VA Medical Center, Minneapolis, MN, USA, Andrew.Hansen2@va.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 181 EP - 184 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 32 IS - 2 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Ankles KW - Walking KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754563092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=Effective+rocker+shapes+used+by+able-bodied+persons+for+walking+and+fore-aft+swaying%3A+Implications+for+design+of+ankle-foot+prostheses&rft.au=Hansen%2C+Andrew+H%3BWang%2C+Charles+C&rft.aulast=Hansen&rft.aufirst=Andrew&rft.date=2010-06-01&rft.volume=32&rft.issue=2&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2010.04.014 LA - English DB - Physical Education Index N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Walking DO - http://dx.doi.org/10.1016/j.gaitpost.2010.04.014 ER - TY - JOUR T1 - Association Between Posttraumatic Stress Disorder and Primary Care Provider-Diagnosed Disease Among Iraq and Afghanistan Veterans AN - 754140998; 201024323 AB - Objective: To determine if a diagnosis of posttraumatic stress disorder (PTSD) was associated with primary care provider-diagnosed physical disease in the first 5 years post deployment. Methods: An examination of medical records of 4416 veterans of Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) was conducted. Participants were veterans who served between September 11,2001 and December 31,2007, without prior combat exposure, and who utilteed primary care services within the VA Healthcare Network of Upstate New York. Primary care provider-diagnosed International Statistical Classification of Diseases and Related Health Problems, Revision 9 (ICD-9) physical diseases were examined. Results: Adjusting for demographic characteristics and clinical factors (e.g., age, gender, depression, and substance use), PTSD was significantly associated with an almost two-fold increase of developing nervous system (odds ratio [OR], 1.98), musculoskeletal disease (OR, 1.84), and signs and ill-defined conditions of disease (OR, 1.78). A diagnosis of PTSD was significantly associated with increased odds of developing circulatory (OR, 1.29), hypertensive (OR, 1.38), and digestive system disease (OR, 1.34). Survival analyses showed that veterans with PTSD experienced early onset disease compared with veterans without PTSD; hypertensive (hazard ratio [HR], 1.56; 95% confidence interval [CI], 1.19-2.04), circulatory, (HR, 1.36; 95% CI, 1.11-1.67), digestive (HR, 1.24; 95% CI, 1.08-1.43), nervous (HR, 1.81; 95% CI, 1.59-2.06), musculoskeletal disease (HR, 1.49; 95% CI, 1.32-1.67), and signs and ill-defined disease (HR, 1.70; 95% CI, 1.51-1.92). Conclusions: PTSD is associated with increased prevalence and onset of physical disease among OEF/OIF veterans within the early years post military service. Rising rates of PTSD may foreshadow an increase in lifespan morbidity and healthcare utilization in the coming years among OEF/OIF veterans. Adapted from the source document. JF - Psychosomatic Medicine AU - Andersen, Judith AU - Wade, Michael AU - Possemato, Kyle AU - Ouimette, Paige AD - Center for Integrated Healthcare, Department of Veterans Affairs Medical Center, Syracuse, NY 13210 Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 498 EP - 504 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 72 IS - 5 SN - 0033-3174, 0033-3174 KW - posttraumatic stress disorder, veterans, disease, cardiovascular, Iraq and Afghanistan War KW - Veterans KW - Diagnosis KW - Posttraumatic stress disorder KW - Musculoskeletal diseases KW - Freedom KW - Primary health care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754140998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+Medicine&rft.atitle=Association+Between+Posttraumatic+Stress+Disorder+and+Primary+Care+Provider-Diagnosed+Disease+Among+Iraq+and+Afghanistan+Veterans&rft.au=Andersen%2C+Judith%3BWade%2C+Michael%3BPossemato%2C+Kyle%3BOuimette%2C+Paige&rft.aulast=Andersen&rft.aufirst=Judith&rft.date=2010-06-01&rft.volume=72&rft.issue=5&rft.spage=498&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+Medicine&rft.issn=00333174&rft_id=info:doi/10.1097%2FPSY.0b013e3181d969a1 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-09-10 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMEAP N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Veterans; Primary health care; Freedom; Diagnosis; Musculoskeletal diseases DO - http://dx.doi.org/10.1097/PSY.0b013e3181d969a1 ER - TY - JOUR T1 - Introducing spirituality, religion and culture curricula in the psychiatry residency programme AN - 754136988; 201021912 AB - A growing body of research suggests that religion and spirituality may have a positive effect on mental and physical health. Medical schools have been increasingly offering courses in spirituality and health, particularly about the multi-cultural dimensions of religion and spirituality. There is a trend towards integrating the teaching of cross-cultural issues related to spirituality and religion into medical education. This trend is particularly evident in the field of psychiatry, where an increasing number of residency programmes are developing curriculum in this area. This article describes a specific curriculum in spirituality, religion and culture that was introduced in 2003 at the University of Washington Psychiatry Residency Program in Seattle, Washington. Reflections about the present and future of subject areas such as spirituality and religion in medical education and psychiatry residency are discussed. Adapted from the source document. JF - Medical Humanities AU - Kozak, Leila AU - Boynton, Lorin AU - Bentley, Jacob AU - Bezy, Emma AD - Health Services R&D Service, Department of Veteran Affairs, VA Puget Sound Health Care System, Department Of Veterans Affairs Medical Center, 1100 Olive Way, Suite 1400, Seattle, WA 98101, USA leila.kozak@va.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 48 EP - 51 PB - BMJ Publishing Group, London UK VL - 36 IS - 1 SN - 1468-215X, 1468-215X KW - Curriculum KW - Spirituality KW - Health status KW - Reflection KW - Medical education KW - Psychiatry KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754136988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Humanities&rft.atitle=Introducing+spirituality%2C+religion+and+culture+curricula+in+the+psychiatry+residency+programme&rft.au=Kozak%2C+Leila%3BBoynton%2C+Lorin%3BBentley%2C+Jacob%3BBezy%2C+Emma&rft.aulast=Kozak&rft.aufirst=Leila&rft.date=2010-06-01&rft.volume=36&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Medical+Humanities&rft.issn=1468215X&rft_id=info:doi/10.1136%2Fjmh.2010.004267 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-08-09 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Spirituality; Psychiatry; Curriculum; Medical education; Reflection; Health status DO - http://dx.doi.org/10.1136/jmh.2010.004267 ER - TY - JOUR T1 - Patterns and Predictors of Late-Life Drinking Trajectories: A 10-Year Longitudinal Study AN - 754135267; 201020073 AB - This study examines the extent of group-level and intra-individual decline in alcohol consumption among adults as they traverse a 10-year interval spanning late-middle to early-old age. Further, it identifies key baseline predictors of these adults' 10-year drinking trajectories. Community residents (n = 1,291; age 55 to 65 years at baseline) were assessed at 4 points over a 10-year interval on demographic and health characteristics, coping responses, social context, and alcohol consumption. Descriptive cross-wave statistics, and multilevel regression analyses, indicated that in the sample overall, participants' 10-year patterns of alcohol consumption were relatively stable. However, men's patterns, and those of individuals drinking beyond recommended alcohol consumption guidelines at baseline, were more variable and showed steeper rates of decline, than did those of women and individuals drinking within recommended levels. Contrary to expectation baseline use of substances to reduce tension and heavier reliance on avoidance coping predicted faster rate of decline in alcohol consumption. Post hoc prospective mediation analyses suggested that this may have occurred because these and other baseline predictors heighten risk of developing new health problems which, in turn, motivate reduced alcohol consumption. [Copyright The American Psychological Association.] JF - Psychology of Addictive Behaviors AU - Brennan, Penny L AU - Schutte, Kathleen K AU - Moos, Rudolf H AD - Center for Health Care Evaluation, VA Palo Alto Health Care System and Stanford University Medical Center penny.brennan@va.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 254 EP - 264 PB - American Psychological Association, Washington DC VL - 24 IS - 2 SN - 0893-164X, 0893-164X KW - older adults alcohol drinking trajectories KW - Alcohol consumption KW - Social context KW - Women KW - Coping KW - Demographic aspects KW - Mediation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754135267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Roanoke+Times&rft.atitle=FEED+MILL+RECYCLES+BETTER%2C+SMARTER%3A+%5BMETRO+EDITION%5D&rft.au=Lois+Caliri+lois.caliri%40roanoke.com+981-3117&rft.aulast=Lois+Caliri+lois.caliri%40roanoke.com+981-3117&rft.aufirst=&rft.date=2004-10-29&rft.volume=&rft.issue=&rft.spage=C.9&rft.isbn=&rft.btitle=&rft.title=The+Roanoke+Times&rft.issn=&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-08-09 N1 - Last updated - 2016-09-27 N1 - CODEN - PABEEI N1 - SubjectsTermNotLitGenreText - Alcohol consumption; Coping; Demographic aspects; Social context; Mediation; Women DO - http://dx.doi.org/10.1037/a0018592 ER - TY - JOUR T1 - A Systematic Review of Suicide Prevention Programs for Military or Veterans AN - 754046672; 201053915 AB - Military personnel and veterans have important suicide risk factors. After a systematic review of the literature on suicide prevention, seven (five in the U.S.) studies of military personnel were identified containing interventions that may reduce the risk of suicide. The effectiveness of the individual components was not assessed, and problems in methodology or reporting of data were common. Overall, multifaceted interventions for active duty military personnel are supported by consistent evidence, although of very mixed quality, and in some cases during intervals of declines in suicide rates in the general population. There were insufficient studies of U.S. Veterans to reach conclusions. Adapted from the source document. JF - Suicide and Life-Threatening Behavior AU - Bagley, Steven C AU - Munjas, Brett AU - Shekelle, Paul AD - Department of Veteran Affairs, Psychiatry, 3801 Miranda Ave, Palo Alto, CA 94304 steven.bagley2@va.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 257 EP - 265 PB - Guilford Publications, New York NY VL - 40 IS - 3 SN - 0363-0234, 0363-0234 KW - Veterans KW - Methodology (Data Collection) KW - Prevention KW - Military Personnel KW - Intervention KW - Suicide KW - article KW - 0623: complex organization; military sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754046672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Suicide+and+Life-Threatening+Behavior&rft.atitle=A+Systematic+Review+of+Suicide+Prevention+Programs+for+Military+or+Veterans&rft.au=Bagley%2C+Steven+C%3BMunjas%2C+Brett%3BShekelle%2C+Paul&rft.aulast=Bagley&rft.aufirst=Steven&rft.date=2010-06-01&rft.volume=40&rft.issue=3&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Suicide+and+Life-Threatening+Behavior&rft.issn=03630234&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2010-09-10 N1 - Number of references - 27 N1 - Last updated - 2016-09-28 N1 - CODEN - SLBEDP N1 - SubjectsTermNotLitGenreText - Suicide; Military Personnel; Veterans; Intervention; Prevention; Methodology (Data Collection) ER - TY - JOUR T1 - Perception of Wet Vocal Quality in Identifying Penetration/Aspiration During Swallowing AN - 753821560; 201018293 AB - Purpose: In the present study, the authors investigated the association between wet vocal quality (WVQ) and prandial material in the larynx during phonation. The presence of such material is indicative of oropharyngeal dysphagia and results from entry of material into the laryngeal vestibule during swallowing. The primary aim of the study was to determine whether clinicians reliably perceive WVQ during phonation when prandial material is in the larynx. Method: Seventy-eight subjects underwent videofluoroscopic swallow study, and simultaneous recording of time-linked videofluoroscopic and acoustic data was conducted during postswallow phonation. Experienced dysphagia clinicians then rated randomized audio samples for presence or absence of WVQ. Results: WVQ is not reliably perceived by clinicians when material is present in the larynx in the region of the glottis during phonation, and there is a high degree of interrater variability for perceptual judgments of wetness. Conclusions: Material in the larynx during phonation may result in multiple voice quality percepts, and even experienced clinicians may not be adept at identifying the perceptual consequences of this. Observation of laryngeal physiology during voicing when material is in the larynx using vocal tract imaging can improve reliability in the identification of wet vocal quality. Adapted from the source document JF - Journal of Speech, Language, and Hearing Research AU - Groves-Wright, Kathy Jean AU - Boyce, Suzanne AU - Kelchner, Lisa AD - Audiology and Speech Pathology Section (126), Cincinnati Veterans Affairs Medical Center, 3200 Vine Street, Cincinnati, OH 45220 kathy.groves@va.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 620 EP - 632 VL - 53 IS - 3 SN - 1092-4388, 1092-4388 KW - Swallowing (86170) KW - Videofluoroscopy (93985) KW - Voice Quality (95200) KW - Phonation (64400) KW - Phonation Structures (64550) KW - Dysphagia (20260) KW - article KW - 6210: hearing and speech physiology; hearing and speech physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753821560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=Perception+of+Wet+Vocal+Quality+in+Identifying+Penetration%2FAspiration+During+Swallowing&rft.au=Groves-Wright%2C+Kathy+Jean%3BBoyce%2C+Suzanne%3BKelchner%2C+Lisa&rft.aulast=Groves-Wright&rft.aufirst=Kathy&rft.date=2010-06-01&rft.volume=53&rft.issue=3&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2010-09-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Phonation Structures (64550); Phonation (64400); Dysphagia (20260); Videofluoroscopy (93985); Swallowing (86170); Voice Quality (95200) ER - TY - JOUR T1 - Gender, depression and physical impairment: an epidemiologic perspective from Aleppo, Syria AN - 746223991; 12942722 AB - Objective: Examine the association of physical impairment with gender, depression, and socio-demographics in the community in Aleppo, Syria. Method: We conducted a cross-sectional, population-based study in Aleppo on adults aged 18-65 (N=2,038). We used a computerized interviewer-administered structured questionnaire. Physical impairment was measured via an adapted 12-item World Health Organization, Health State Description Individual Questionnaire which includes both physical and emotional items. We used physical impairment items score to classify individuals into low, middle, and high physical impairment category. Self-report of physician-diagnosed depression and chronic diseases active in the past year and their current treatment status were obtained. Results: Sample mean age (SD) was 35.3 (12.1) years, 55% were female, and 4.5% had depression. Female gender, low socioeconomic status (SES), and depression were associated with high physical impairment. Women had more impairment (OR=3.35, 95% CI: 2.15-5.21) with little change after controlling for depression and chronic diseases, but significantly decreased after controlling for socio-demographics (OR=1.51, 95% CI: 0.84-2.73). The association with low (vs. high) SES was prominent (OR=2.48, 95% CI: 1.32-4.67) after controlling for all variables. Depression's association (OR=4.85, 95% CI: 1.93-12.15) lost significance after controlling for chronic diseases (OR=2.81, 95% CI: 0.96-8.25), but further adjustment for socio-demographics had little effect. Conclusion: Women and individuals of low SES appear more vulnerable to physical impairment in the community in Aleppo. Depression's association with physical impairment may be mediated through co-existing chronic diseases. Public health planning regarding physical impairment in Syria should encompass these as putative risk factors. JF - Social Psychiatry and Psychiatric Epidemiology AU - Kilzieh, Nael AU - Rastam, Samer AU - Ward, Kenneth D AU - Maziak, Wasim AD - American Lake Division, VA Puget Sound Health Care System, 9600 Veterans Drive, A-116, Tacoma, WA, 98493, USA, nael.kilzieh@va.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 595 EP - 602 PB - Springer-Verlag (New York), P.O. Box 2485 Secaucus NJ 07096-2485 USA VL - 45 IS - 6 SN - 0933-7954, 0933-7954 KW - Risk Abstracts KW - Age KW - Syria KW - Socioeconomics KW - depression KW - Public health KW - Gender KW - vulnerability KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746223991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Psychiatry+and+Psychiatric+Epidemiology&rft.atitle=Gender%2C+depression+and+physical+impairment%3A+an+epidemiologic+perspective+from+Aleppo%2C+Syria&rft.au=Kilzieh%2C+Nael%3BRastam%2C+Samer%3BWard%2C+Kenneth+D%3BMaziak%2C+Wasim&rft.aulast=Kilzieh&rft.aufirst=Nael&rft.date=2010-06-01&rft.volume=45&rft.issue=6&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Social+Psychiatry+and+Psychiatric+Epidemiology&rft.issn=09337954&rft_id=info:doi/10.1007%2Fs00127-009-0076-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Age; Gender; Socioeconomics; vulnerability; depression; Public health; Syria DO - http://dx.doi.org/10.1007/s00127-009-0076-7 ER - TY - JOUR T1 - Predictors of Resilience Among Inner City Youths AN - 746223607; 12850569 AB - Prior studies have suggested that living in high-risk neighborhoods is associated with youths' maladjustment. Youths who maintained favorable outcomes, despite being exposed to such neighborhood risks, were considered resilient. Using structural equation modeling techniques, longitudinal data of 877 youths from the Denver Youth Survey were examined to identify predictors of resilience, longitudinal interrelations among predictors, and bi-directional relationships between resilience and life context factors. Resilience was longitudinally predicted by bonding to family and teachers, involvement in extracurricular activities, lower levels of parental discord, fewer adverse life events, and being less involved with delinquent peers. A positive feedback loop was found, in which resilience predicted further resilience. Early intervention to strengthen traditional bonding, decrease involvement with delinquent peers, and reduce the effects of adverse life events and parental discord may be essential in enhancing functioning of high-risk youths. JF - Journal of Child and Family Studies AU - Tiet, Quyen Q AU - Huizinga, David AU - Byrnes, Hilary F AD - Clinical Psychology PhD Program, California School of Professional Psychology at the Alliant International University, San Francisco, CA, 94133, USA, Quyen.Tiet@va.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 360 EP - 378 PB - Springer New York, LLC, 233 Spring St New York NY 10013-1578 USA VL - 19 IS - 3 SN - 1062-1024, 1062-1024 KW - Risk Abstracts KW - inner cities KW - Family studies KW - USA, Colorado, Denver KW - Behavior KW - intervention KW - Ethnic groups KW - Urban areas KW - Quality of life KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746223607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+and+Family+Studies&rft.atitle=Predictors+of+Resilience+Among+Inner+City+Youths&rft.au=Tiet%2C+Quyen+Q%3BHuizinga%2C+David%3BByrnes%2C+Hilary+F&rft.aulast=Tiet&rft.aufirst=Quyen&rft.date=2010-06-01&rft.volume=19&rft.issue=3&rft.spage=360&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+and+Family+Studies&rft.issn=10621024&rft_id=info:doi/10.1007%2Fs10826-009-9307-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - inner cities; Behavior; intervention; Ethnic groups; Family studies; Quality of life; Urban areas; USA, Colorado, Denver DO - http://dx.doi.org/10.1007/s10826-009-9307-5 ER - TY - JOUR T1 - Randomized trial showed that an " embedded" survey strategy optimized authorization rates compared with two " after survey" strategies in veterans with PTSD AN - 746078127; 13038779 AB - Objectives - To test methods to optimize mail survey response and authorization rates (i.e., allowing one's survey to be linked to medical records) when the survey is sensitive and the targeted population has a mental disorder. Study Design and Setting - Randomized controlled trial of 1,099 veterans treated for posttraumatic stress disorder (PTSD) at a Midwestern Veteran Affairs Medical Center. Subjects were randomized to one of three groups: (1) Health Insurance Portability and Accountability Act (HIPAA) authorization form embedded in the survey (checking "yes" for consent); (2) HIPAA form requiring signature for consent sent after the survey; or (3) HIPAA form requiring a signature and social security number (SSN) for consent sent after the survey. Results - The "embedded" strategy yielded the lowest survey response rate (67.5%) but highest authorization rate (59.1%). Requiring respondents' signatures and SSNs after the survey was returned generated the highest survey response rate (74.2%) but lowest authorization rate (48.7%). However, the response rate difference was not statistically significant. Reported emotional upset was low (1.5%) and primarily directed to the survey, not the HIPAA form. Older age and greater trustfulness were associated with higher authorization rates. Conclusion - Even with our most optimized strategy, authorization rates were disappointingly low. JF - Journal of Clinical Epidemiology AU - Murdoch, Maureen AU - Pietila, Diane M AU - Partin, Melissa R AD - Center for Chronic Disease Outcomes Research, Minneapolis VA Medical Center, Minneapolis, MN, USA, Maureen.Murdoch@va.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 665 EP - 671 PB - Elsevier Science, Box 882 New York NY 10159 United States of America VL - 63 IS - 6 SN - 0895-4356, 0895-4356 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746078127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Epidemiology&rft.atitle=Randomized+trial+showed+that+an+%22+embedded%22+survey+strategy+optimized+authorization+rates+compared+with+two+%22+after+survey%22+strategies+in+veterans+with+PTSD&rft.au=Murdoch%2C+Maureen%3BPietila%2C+Diane+M%3BPartin%2C+Melissa+R&rft.aulast=Murdoch&rft.aufirst=Maureen&rft.date=2010-06-01&rft.volume=63&rft.issue=6&rft.spage=665&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Epidemiology&rft.issn=08954356&rft_id=info:doi/10.1016%2Fj.jclinepi.2009.12.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1016/j.jclinepi.2009.12.006 ER - TY - JOUR T1 - Subjective anxiety and behavioral avoidance: Gender, gender role, and perceived confirmability of self-report AN - 742722033; 201013897 AB - Commonly reported gender effects for differential vulnerability for anxiety may relate to gender socialization processes. The present study examined the relationship between gender role and fear under experimental conditions designed to elicit accurate fear reporting. Undergraduate students (N = 119) completed several self-report measures and a behavioral avoidance task (BAT) with a tarantula while wearing a heart rate monitor. Gender roles were operationalized as instrumentality and expressiveness, as measured by the Personal Attributes Questionnaire (Spence, Helmreich, & Stapp, 1975). As expected, women reported greater subjective anxiety and were more avoidant of the tarantula than men. Regardless of gender, low levels of instrumentality were associated with greater avoidance of the tarantula. The hypothesis that men underreport fear compared to women and that gender role differences underlie this reporting bias was not supported. In spite of a ceiling effect on the BAT, results of this study confirm the relevance of gender role in understanding gender effects in fear and anxiety. [Copyright Elsevier B.V.] JF - Journal of Anxiety Disorders AU - McLean, Carmen P AU - Hope, Debra A AD - Department of Psychology, University of Nebraska - Lincoln, Lincoln, USA carmen.mclean@va.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 494 EP - 502 PB - Elsevier Ltd, The Netherlands VL - 24 IS - 5 SN - 0887-6185, 0887-6185 KW - Gender role Anxiety Gender differences Behavioral avoidance KW - Anxiety KW - Avoidance KW - Fear KW - Gender differences KW - Gender roles KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742722033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Anxiety+Disorders&rft.atitle=Subjective+anxiety+and+behavioral+avoidance%3A+Gender%2C+gender+role%2C+and+perceived+confirmability+of+self-report&rft.au=McLean%2C+Carmen+P%3BHope%2C+Debra+A&rft.aulast=McLean&rft.aufirst=Carmen&rft.date=2010-06-01&rft.volume=24&rft.issue=5&rft.spage=494&rft.isbn=&rft.btitle=&rft.title=Journal+of+Anxiety+Disorders&rft.issn=08876185&rft_id=info:doi/10.1016%2Fj.janxdis.2010.03.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-06-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Gender differences; Anxiety; Fear; Avoidance; Gender roles DO - http://dx.doi.org/10.1016/j.janxdis.2010.03.006 ER - TY - JOUR T1 - Individual, social environmental and physical environmental barriers to achieving 10,000 steps per day among older women AN - 742713166; 201016315 AB - This study examined the determinants of attaining/not attaining 10000 steps per day among older women. Methods: Daily step counts over 7 days were measured using accelerometry. Self-reported environmental characteristics, self-efficacy, social support and functional limitations were assessed in 128 older women. The presence of areas for activity within 1 km of each participant's residence was assessed using Geographic Information Systems. Multivariate analysis of variances were used to examine the degree to which these groups differed on measured constructs, and discriminant analysis was used to determine the profiles that discriminate among those who did not attain 10000 steps per day and those who did. Results: Participants who did not attain 10000 steps per day reported lower self-efficacy (P < 0.05), greater functional limitations (P < 0.05), had significantly fewer walking paths (P < 0.05) within 1 km of their home and reported significantly less street connectivity (P < 0.05) and safety from traffic (P < 0.05) than those who achieved 10000 steps per day. Conclusion: Lack of perceived and actual environmental supports for walking, more functional limitations and lower self-efficacy are barriers to achieving 10000 steps per day. The absence of these individual and environmental characteristics inhibits walking behavior in older women and should be considered in campaigns to promote a physically active lifestyle. Adapted from the source document. JF - Health Education Research AU - Hall, Katherine S AU - McAuley, Edward AD - Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, 508 Fulton Street, GRECC 182, Durham, NC 27705, USA Katherine.hall3@va.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 478 EP - 488 PB - Oxford University Press, UK VL - 25 IS - 3 SN - 0268-1153, 0268-1153 KW - Selfefficacy KW - Discriminant analysis KW - Environmental aspects KW - Walking KW - Functional impairment KW - Older women KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742713166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+Research&rft.atitle=Individual%2C+social+environmental+and+physical+environmental+barriers+to+achieving+10%2C000+steps+per+day+among+older+women&rft.au=Hall%2C+Katherine+S%3BMcAuley%2C+Edward&rft.aulast=Hall&rft.aufirst=Katherine&rft.date=2010-06-01&rft.volume=25&rft.issue=3&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=Health+Education+Research&rft.issn=02681153&rft_id=info:doi/10.1093%2Fher%2Fcyq019 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - HRTPE2 N1 - SubjectsTermNotLitGenreText - Older women; Selfefficacy; Functional impairment; Walking; Environmental aspects; Discriminant analysis DO - http://dx.doi.org/10.1093/her/cyq019 ER - TY - JOUR T1 - Written Emotional Expression During Recovery From Cocaine Dependence: Group and Individual Differences in Craving Intensity AN - 741611579; 201007503 AB - We conducted a prospective, single-blind, parallel group, controlled trial to evaluate effects of written emotional expression in patients receiving intensive treatment for cocaine dependence in a residential-unit setting. Randomization to the emotional expression treatment produced changes in blood pressure and mood during writing sessions, possibly because of its ability to stimulate active coping behavior. At an initial follow-up visit, patients that had received written emotional expression reported lower values for craving intensity and were less likely to self-report use of cocaine. These results may indicate a therapeutic effect of written emotional expression during recovery from cocaine dependence. Adapted from the source document. JF - Substance Use & Misuse AU - Grasing, Kenneth AU - Mathur, Deepan AU - Desouza, Cherilyn AD - Department of Veterans Affairs Medical Center, Research Service 151, Kansas City, Missouri, USA kenneth.grasing@med.va.gov. Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 1201 EP - 1215 PB - Taylor & Francis, Philadelphia PA VL - 45 IS - 7-8 SN - 1082-6084, 1082-6084 KW - Values KW - Individual Differences KW - Patients KW - Self Expression KW - Coping KW - Cocaine KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/741611579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=Written+Emotional+Expression+During+Recovery+From+Cocaine+Dependence%3A+Group+and+Individual+Differences+in+Craving+Intensity&rft.au=Grasing%2C+Kenneth%3BMathur%2C+Deepan%3BDesouza%2C+Cherilyn&rft.aulast=Grasing&rft.aufirst=Kenneth&rft.date=2010-06-01&rft.volume=45&rft.issue=7-8&rft.spage=1201&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.3109%2F10826080903474003 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-06-07 N1 - Last updated - 2016-09-28 N1 - CODEN - SUMIFL N1 - SubjectsTermNotLitGenreText - Self Expression; Cocaine; Patients; Values; Individual Differences; Coping DO - http://dx.doi.org/10.3109/10826080903474003 ER - TY - JOUR T1 - Change in Goal Ratings as a Mediating Variable Between Self-efficacy and Physical Activity in Older Men AN - 1458527167; 16467208 AB - Background: Few studies have examined the associations between exercise self-efficacy, goals, and physical activity over time. Purpose: This study examines whether self-selected goals mediate the changes in exercise self-efficacy on physical activity over 12 months. Methods: Data are derived from 313 older men participating in the Veterans LIFE Study. Results: Changes in exercise self-efficacy were significantly associated with changes in physical activity both directly ( beta s=0.25 and 0.24, p<0.05) and indirectly ( beta s=0.24 and 0.30, p<0.05) through changes in health-related and walking goal ratings ( beta s=0.19 and 0.20, p<0.05). Both types of goal setting continued to partially mediate the relationship between exercise self-efficacy and physical activity when covariates were added to the models. Conclusion: This study extends the application of social cognitive and goal-setting theories to physical activity by showing that goals partially mediate the relationship between exercise self-efficacy and physical activity over time. JF - Annals of Behavioral Medicine AU - Hall, Katherine S AU - Crowley, Gail M AU - McConnell, Eleanor S AU - Bosworth, Hayden B AU - Sloane, Richard AU - Ekelund, Carola C AU - Morey, Miriam C AD - Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, GRECC 182, 508 Fulton St., Durham, NC, 27705, USA, katherine.hall3@va.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 267 EP - 273 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 39 IS - 3 SN - 0883-6612, 0883-6612 KW - Physical Education Index KW - Men KW - Exercise (goals) KW - Gerontology KW - Walking KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1458527167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Behavioral+Medicine&rft.atitle=Change+in+Goal+Ratings+as+a+Mediating+Variable+Between+Self-efficacy+and+Physical+Activity+in+Older+Men&rft.au=Hall%2C+Katherine+S%3BCrowley%2C+Gail+M%3BMcConnell%2C+Eleanor+S%3BBosworth%2C+Hayden+B%3BSloane%2C+Richard%3BEkelund%2C+Carola+C%3BMorey%2C+Miriam+C&rft.aulast=Hall&rft.aufirst=Katherine&rft.date=2010-06-01&rft.volume=39&rft.issue=3&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Annals+of+Behavioral+Medicine&rft.issn=08836612&rft_id=info:doi/10.1007%2Fs12160-010-9177-5 LA - English DB - Physical Education Index N1 - Date revised - 2013-11-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Men; Exercise (goals); Gerontology; Walking DO - http://dx.doi.org/10.1007/s12160-010-9177-5 ER - TY - CPAPER T1 - Demographic and Occupational Characteristics Predict Differences in Workplace Civility Perceptions T2 - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AN - 754290610; 5851977 JF - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AU - Osatuke, Katerine AU - Moore, Scott AU - Dyrenforth, Sue Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - Perception KW - Demography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754290610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.atitle=Demographic+and+Occupational+Characteristics+Predict+Differences+in+Workplace+Civility+Perceptions&rft.au=Osatuke%2C+Katerine%3BMoore%2C+Scott%3BDyrenforth%2C+Sue&rft.aulast=Osatuke&rft.aufirst=Katerine&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.psychologicalscience.org/convention/program_2010/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Respiratory Protection Clinical Experience in the VA System T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754241568; 5779744 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Eagan, A Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Respiratory system KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754241568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Respiratory+Protection+Clinical+Experience+in+the+VA+System&rft.au=Eagan%2C+A&rft.aulast=Eagan&rft.aufirst=A&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Comparative Effectiveness Research: Present Status T2 - Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke 2010 Scientific Sessions AN - 754218653; 5795409 JF - Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke 2010 Scientific Sessions AU - Kupersmith, Joel Y1 - 2010/05/19/ PY - 2010 DA - 2010 May 19 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754218653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Quality+of+Care+and+Outcomes+Research+in+Cardiovascular+Disease+and+Stroke+2010+Scientific+Sessions&rft.atitle=Comparative+Effectiveness+Research%3A+Present+Status&rft.au=Kupersmith%2C+Joel&rft.aulast=Kupersmith&rft.aufirst=Joel&rft.date=2010-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Quality+of+Care+and+Outcomes+Research+in+Cardiovascular+Disease+and+Stroke+2010+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/downloadable/heart/1272405119904KB-0003%2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A National Comparison of Psychotherapy Utilization by Rural and Urban Veterans T2 - 33rd Annual Conference of the National Rural Health Association AN - 754246854; 5804149 JF - 33rd Annual Conference of the National Rural Health Association AU - Jameson, John Y1 - 2010/05/18/ PY - 2010 DA - 2010 May 18 KW - Rural areas KW - Psychotherapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754246854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=33rd+Annual+Conference+of+the+National+Rural+Health+Association&rft.atitle=A+National+Comparison+of+Psychotherapy+Utilization+by+Rural+and+Urban+Veterans&rft.au=Jameson%2C+John&rft.aulast=Jameson&rft.aufirst=John&rft.date=2010-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=33rd+Annual+Conference+of+the+National+Rural+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.ruralhealthweb.org/index.cfm?objectid=8DF46ECD-3048-651A-FE LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Va Technology Assessment Advisory Group: Informing Evidence-Based Policy Recommendations for Robotic Prostatectomy T2 - 15th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR 2010) AN - 754223396; 5791818 JF - 15th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR 2010) AU - Adams, E Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 KW - Technology assessment KW - Robotics KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754223396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+International+Meeting+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research+%28ISPOR+2010%29&rft.atitle=The+Va+Technology+Assessment+Advisory+Group%3A+Informing+Evidence-Based+Policy+Recommendations+for+Robotic+Prostatectomy&rft.au=Adams%2C+E&rft.aulast=Adams&rft.aufirst=E&rft.date=2010-05-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+International+Meeting+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research+%28ISPOR+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ispor.org/meetings/atlanta0510/documents/mini-prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Incidence of Atrial Arrhythmias in Pacemaker Patients with and without Sick Sinus Syndrome T2 - 31st Annual Scientific Sessions of the Heart Rhythm Society (Heart Rhythm 2010) AN - 839712916; 5937243 JF - 31st Annual Scientific Sessions of the Heart Rhythm Society (Heart Rhythm 2010) AU - Bersohn, Malcolm Y1 - 2010/05/12/ PY - 2010 DA - 2010 May 12 KW - {Q1} KW - Arrhythmia KW - Sinus KW - Pacemakers KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839712916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=31st+Annual+Scientific+Sessions+of+the+Heart+Rhythm+Society+%28Heart+Rhythm+2010%29&rft.atitle=Incidence+of+Atrial+Arrhythmias+in+Pacemaker+Patients+with+and+without+Sick+Sinus+Syndrome&rft.au=Bersohn%2C+Malcolm&rft.aulast=Bersohn&rft.aufirst=Malcolm&rft.date=2010-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=31st+Annual+Scientific+Sessions+of+the+Heart+Rhythm+Society+%28Heart+Rhythm+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={11A396D9-0C49-480 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - JOUR T1 - The effects of everyday concurrent tasks on overground minimum toe clearance and gait parameters AN - 754870396; 13214759 AB - Deaths and injuries resulting from falls are a significant problem for older adults. Over half of falls during walking result from a trip, and these are likely to begin when the foot contacts the ground at the point of minimum toe clearance (MTC) during the swing phase where the foot most closely approaches the ground. MTC is commonly investigated using a limited number of points and on a treadmill, which cannot account for flooring irregularities, speed changes, and direction changes of overground gait. This paper presents a new method of calculating 3D overground MTC that accounts for flooring variations and utilizes hundreds of points on each shoe. These methods are applied to 10 unimpaired adults during habitual gait: (1) without a concurrent task, (2) while carrying a 9-kg laundry basket, (3) while carrying a tray with a full glass of water on it, and (4) while answering standardized conversational questions. Results indicated that steps were slower and shorter during concurrent tasks while MTC changes were dependent on task type (higher for basket, lower for questions, and unchanged for water). Task-related MTC changes were independent of spatiotemporal gait changes. Thus, MTC during overground gait, particularly while concurrent tasks are being performed, may be an independent fall risk factor that merits further investigation in subjects at-risk of falls. The relationships between MTC, gait parameters, and older age or fall risk should be explored further in at-risk subjects and circumstances to elucidate potential tripping mechanisms. JF - Gait & Posture AU - Schulz, Brian W AU - Lloyd, John D AD - HSR&D/RR&D Center of Excellence-Maximizing Rehabilitation Outcomes, James A. Haley VA Hospital, 8900 Grand Oak Circle, Tampa, FL 33637-1022, USA, Brian.Schulz@va.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 18 EP - 22 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 32 IS - 1 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Adults KW - Gait KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754870396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=The+effects+of+everyday+concurrent+tasks+on+overground+minimum+toe+clearance+and+gait+parameters&rft.au=Schulz%2C+Brian+W%3BLloyd%2C+John+D&rft.aulast=Schulz&rft.aufirst=Brian&rft.date=2010-05-01&rft.volume=32&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2010.02.013 LA - English DB - Physical Education Index N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Gait DO - http://dx.doi.org/10.1016/j.gaitpost.2010.02.013 ER - TY - JOUR T1 - Use of Partial Body-Weight Support for Aggressive Return to Running After Lumbar Disk Herniation: A Case Report AN - 754869344; 13210436 AB - Moore MN, Vandenakker-Albanese C, Hoffman> Use of partial body-weight support for aggressive return to running after lumbar disk herniation: a case report. This case report demonstrates the application of partial body-weight supported treadmill running in an aggressive rehabilitation program of an ultramarathon runner who had sustained a lumbar disk herniation. Body-weight supported exercise has recognized value during rehabilitation of lower-extremity injuries. In this case we found that the reductions in vertical loading forces achieved through partial body-weight support can also be valuable in the rehabilitation of an injury above the level of support. This motivated runner successfully used weight-supported treadmill training within 1 week of an acute lumbar disk herniation when he was experiencing considerable pain with unsupported walking and lower-extremity weakness. He continued its use until he adequately improved to allow return to his regular overground running program. This case demonstrates how partial body-weight support can allow aggressive running training early after a lumbar disk injury when normal impact forces cannot be tolerated and when leg weakness is a limitation. JF - Archives of Physical Medicine and Rehabilitation AU - Moore, Melita N AU - Vandenakker-Albanese, Carol AU - Hoffman, Martin D AD - Department of Physical Medicine and Rehabilitation, University of California-Davis Health Care System, Sacramento, CA, martin.hoffman@va.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 803 EP - 805 PB - Elsevier BV, The Curtis Center, Independence Square West Philadelphia PA 19106-3399 USA VL - 91 IS - 5 SN - 0003-9993, 0003-9993 KW - Physical Education Index KW - Archives KW - Running KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754869344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Use+of+Partial+Body-Weight+Support+for+Aggressive+Return+to+Running+After+Lumbar+Disk+Herniation%3A+A+Case+Report&rft.au=Moore%2C+Melita+N%3BVandenakker-Albanese%2C+Carol%3BHoffman%2C+Martin+D&rft.aulast=Moore&rft.aufirst=Melita&rft.date=2010-05-01&rft.volume=91&rft.issue=5&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/10.1016%2Fj.apmr.2010.01.014 LA - English DB - Physical Education Index N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Running DO - http://dx.doi.org/10.1016/j.apmr.2010.01.014 ER - TY - JOUR T1 - Evaluation of audiometric threshold shift criteria for ototoxicity monitoring. AN - 754147814; pmid-20569665 AB - There is disagreement about ototoxicity monitoring methods. Controversy exists about what audiometric threshold shift criteria should be used, which frequencies should be tested, and with what step size. An evaluation of the test performance achieved using various criteria and methods for ototoxicity monitoring may help resolve these issues.(1) Evaluate test performance achieved using various significant threshold shift (STS) definitions for ototoxicity monitoring in a predominately veteran population; and (2) determine whether testing in (1/6)- or (1/3)-octave steps improves test performance compared to (1/2)-octave steps.A prospective, observational study design was used in which STSs were evaluated at frequencies within an octave of each subject's high-frequency hearing limit at two time points, an early monitoring test and the final monitoring test.Data were analyzed from 78 ears of 41 patients receiving cisplatin and from 53 ears of 28 hospitalized patients receiving nonototoxic antibiotics. Cisplatin-treated subjects received a cumulative dosage > or =350 mg by the final monitoring test. Testing schedule, age, and pre-exposure hearing characteristics were similar between the subject groups.Threshold shifts relative to baseline were examined to determine whether they met criteria based on magnitudes of positive STS (shifts of > or =5, 10, 15, or 20 dB) and numbers of frequencies affected (shifts at > or =1, 2, or 3 adjacent frequencies) for data collected using approximately (1/6)-, (1/3)-, or (1/2)-octave steps. Thresholds were confirmed during monitoring sessions in which shifts were identified. Test performance was evaluated with receiver operating characteristic (ROC) curves developed using a surrogate "gold standard"; true positive (TP) rates were derived from the cisplatin-exposed group and false positive (FP) rates from the nonexposed, control group. Best STS definitions were identified that achieved the greatest areas under ROC curves or resulted in the highest TP rates for a fixed FP rate near 5%, chosen to minimize the number of patients incorrectly diagnosed with ototoxic hearing loss.At the early monitoring test, average threshold shifts differed only slightly across groups. Test-frequency step size did not affect performance, and changes at one or more frequencies yielded the best test performance. At the final monitoring test, average threshold shifts were +10.5 dB for the cisplatin group, compared with -0.2 dB for the control group. Compared with the (1/2)-octave step size used clinically, use of smaller frequency steps improved test performance for threshold shifts at > or =2 or > or =3 adjacent frequencies. Best overall test performance was achieved using a criterion cutoff of > or =10 dB threshold shift at > or =2 adjacent frequencies tested in (1/6)-octave steps. Best test performance for the (1/2)-octave step size was achieved for shifts > or =15 dB at one or more frequencies.An ototoxicity monitoring protocol that uses an individualized, one-octave range of frequencies tested in (1/6)-octave steps is quick to administer and has an acceptable FP rate. Similar test performance can be achieved using (1/3)-octave test frequencies, which further reduces monitoring test time.American Academy of Audiology. JF - Journal of the American Academy of Audiology AU - Konrad-Martin, Dawn AU - James, Kenneth E AU - Gordon, Jane S AU - Reavis, Kelly M AU - Phillips, David S AU - Bratt, Gene W AU - Fausti, Stephen A AD - VA RR&D National Center for Rehabilitative Auditory Research, Portland VA Medical Center, OR, USA. dawn.martin@va.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 301 EP - 14; quiz 357 VL - 21 IS - 5 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Antineoplastic Agents: adverse effects KW - Auditory Threshold: drug effects KW - *Cisplatin: adverse effects KW - *Drug Monitoring: methods KW - *Hearing Loss: chemically induced KW - Hearing Loss: diagnosis KW - Humans KW - Male KW - Middle Aged KW - Neoplasms: drug therapy KW - *Otoacoustic Emissions, Spontaneous: drug effects KW - Prognosis KW - Prospective Studies KW - ROC Curve UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754147814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Evaluation+of+audiometric+threshold+shift+criteria+for+ototoxicity+monitoring.&rft.au=Konrad-Martin%2C+Dawn%3BJames%2C+Kenneth+E%3BGordon%2C+Jane+S%3BReavis%2C+Kelly+M%3BPhillips%2C+David+S%3BBratt%2C+Gene+W%3BFausti%2C+Stephen+A&rft.aulast=Konrad-Martin&rft.aufirst=Dawn&rft.date=2010-05-01&rft.volume=21&rft.issue=5&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Leptin deficiency-induced obesity exacerbates ultraviolet B radiation-induced cyclooxygenase-2 expression and cell survival signals in ultraviolet B-irradiated mouse skin AN - 746003768; 13029659 AB - Obesity has been implicated in several inflammatory diseases and in different types of cancer. Chronic inflammation induced by exposure to ultraviolet (UV) radiation has been implicated in various skin diseases, including melanoma and nonmelanoma skin cancers. As the relationship between obesity and susceptibility to UV radiation-caused inflammation is not clearly understood, we assessed the role of obesity on UVB-induced inflammation, and mediators of this inflammatory response, using the genetically obese (leptin-deficient) mouse model. Leptin-deficient obese (ob/ob) mice and wild-type counterparts (C57/BL6 mice) were exposed to UVB radiation (120 mJ/cm2) on alternate days for 1 month. The mice were then euthanized and skin samples collected for analysis of biomarkers of inflammatory responses using immunohistochemistry, western blotting, ELISA and real-time PCR. Here, we report that the levels of inflammatory responses were higher in the UVB-exposed skin of the ob/ob obese mice than those in the UVB-exposed skin of the wild-type non-obese mice. The levels of UVB-induced cyclooxygenase-2 expression, prostaglandin-E2 production, proinflammatory cytokines (i.e., tumor necrosis factor-a, interleukin-1b, interleukin-6), and proliferating cell nuclear antigen and cell survival signals (phosphatidylinositol-3-kinase and p-Akt-Ser473) were higher in the skin of the ob/ob obese mice than the those in skin of their wild-type non-obese counterparts. Compared with the wild-type non-obese mice, the leptin-deficient obese mice also exhibited greater activation of NF-I[ordmB/p65 and fewer apoptotic cells in the UVB-irradiated skin. Our study suggests for the first time that obesity in mice is associated with greater susceptibility to UVB-induced inflammatory responses and, therefore, obesity may increase susceptibility to UVB-induced inflammation-associated skin diseases, including the risk of skin cancer. JF - Toxicology and Applied Pharmacology AU - Sharma, Som D AU - Katiyar, Santosh K AD - Birmingham Veterans Administration Medical Center, Birmingham, AL 35294, USA Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 SP - 328 EP - 335 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 244 IS - 3 SN - 0041-008X, 0041-008X KW - Environment Abstracts; Toxicology Abstracts KW - 1-Phosphatidylinositol 3-kinase KW - Obesity KW - Skin KW - X 24390:Radioactive Materials KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746003768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Leptin+deficiency-induced+obesity+exacerbates+ultraviolet+B+radiation-induced+cyclooxygenase-2+expression+and+cell+survival+signals+in+ultraviolet+B-irradiated+mouse+skin&rft.au=Sharma%2C+Som+D%3BKatiyar%2C+Santosh+K&rft.aulast=Sharma&rft.aufirst=Som&rft.date=2010-05-01&rft.volume=244&rft.issue=3&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2010.01.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Obesity; Skin DO - http://dx.doi.org/10.1016/j.taap.2010.01.010 ER - TY - JOUR T1 - Cognitive-affective characteristics of smokers with and without posttraumatic stress disorder and panic psychopathology AN - 745706340; 12966874 AB - The present study evaluated differences among daily smokers with posttraumatic stress disorder (PTSD), panic disorder (PD), panic attacks (PA), and no axis I psychopathology (past 6 months) in terms of several cognitive-affective variables implicated in both the onset and maintenance of anxiety psychopathology and cigarette smoking. The sample consisted of 123 daily smokers (62% women: M sub(age) = 29.7, SD = 11.9). Compared to the PA and no psychopathology groups, the PTSD group reported significantly higher levels of anxiety sensitivity, discomfort intolerance, negative affectivity, anxious arousal, and anhedonic depression; and, the PTSD group reported significantly lower levels of perceived control over anxiety-related events than the PA group. The PD group, compared to those in the PA and no psychopathology groups, reported significantly higher levels of anxiety sensitivity, negative affectivity, and anxious arousal; and significantly lower levels of perceived control over anxiety-related events. No significant differences were evident between the PTSD and PD groups. Theoretical and clinical implications of the present findings are discussed in terms of smoking and emotional vulnerability. JF - Addictive Behaviors AU - Vujanovic, Anka A AU - Marshall, Erin C AU - Gibson, Laura E AU - Zvolensky, Michael J AD - National Center for PTSD - Behavioral Science Division, VA Boston Healthcare System, United States, anka.vujanovic@va.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 419 EP - 425 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 35 IS - 5 SN - 0306-4603, 0306-4603 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Anxiety KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745706340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+Behaviors&rft.atitle=Cognitive-affective+characteristics+of+smokers+with+and+without+posttraumatic+stress+disorder+and+panic+psychopathology&rft.au=Vujanovic%2C+Anka+A%3BMarshall%2C+Erin+C%3BGibson%2C+Laura+E%3BZvolensky%2C+Michael+J&rft.aulast=Vujanovic&rft.aufirst=Anka&rft.date=2010-05-01&rft.volume=35&rft.issue=5&rft.spage=419&rft.isbn=&rft.btitle=&rft.title=Addictive+Behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2009.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Anxiety DO - http://dx.doi.org/10.1016/j.addbeh.2009.12.005 ER - TY - JOUR T1 - Mortality Patterns of Army Chemical Corps Veterans Who were Occupationally Exposed to Herbicides in Vietnam AN - 744624338; 13043307 AB - Purpose - This research examined the risk of disease-related mortality of the Army Chemical Corps (ACC) veterans who handled/sprayed herbicides in Vietnam in comparison with their non-Vietnam veteran peers or U.S. men. Methods - Vital status was determined through December 31, 2005. All-cause mortality and cause-specific mortality were compared for individuals who served in Vietnam (n = 2872) versus those who did not (n = 2737). Similar analyses were completed on a subset of the original Vietnam cohort that consisted of individuals who either reported spraying herbicide (n = 662) or not (n = 811). The observed deaths for each of the two base cohorts were also compared with expected deaths for U.S. men. Results - Statistically significant excess mortality was found for ACC Vietnam veterans for chronic obstructive pulmonary disease (adjusted relative risk [ARR], 4.82; 95% confidence interval [95% CI], 1.10-21.18). When examining patterns for veterans in the Vietnam veteran subset, we found nonsignificant elevated ARRs among herbicide sprayers for all-cause, respiratory system disease, and respiratory system cancer mortality. Compared with U.S. men, the Vietnam veteran cohort had significant excess mortality for all-causes (standardized mortality ratio [SMR], 1.13; 95% CI, 1.04-1.23), respiratory system cancer (SMR, 1.35; 95% CI, 1.03-1.73), nonmalignant respiratory system disease (SMR, 1.58; 95% CI, 1.08-2.23), and miscellaneous malignant cancers (SMR, 1.77; 95% CI, 1.03-2.84). Conclusions - The risk of mortality from respiratory disease (malignant or nonmalignant) was significantly greater for ACC Vietnam veterans in comparison with their non-Vietnam veteran peers and U.S. men. Herbicide exposure could be contributing to the patterns observed. Because of the unique nature of their military duties and study limitations, findings may not be generalizeable to Vietnam veterans as a whole. JF - Annals of Epidemiology AU - Cypel, Yasmin AU - Kang, Han AD - Environmental Epidemiology Service (135), Department of Veterans Affairs, Washington,, yasmin.cypel@va.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 339 EP - 346 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 20 IS - 5 SN - 1047-2797, 1047-2797 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Army Chemical Corps KW - Herbicides KW - Mortality KW - Veterans KW - Vietnam War KW - Sprays KW - Respiratory diseases KW - Mortality patterns KW - Cancer KW - Vietnam KW - USA KW - Standards KW - Military KW - Occupational exposure KW - Respiratory system KW - chronic obstructive pulmonary disease KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744624338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Mortality+Patterns+of+Army+Chemical+Corps+Veterans+Who+were+Occupationally+Exposed+to+Herbicides+in+Vietnam&rft.au=Cypel%2C+Yasmin%3BKang%2C+Han&rft.aulast=Cypel&rft.aufirst=Yasmin&rft.date=2010-05-01&rft.volume=20&rft.issue=5&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2010.02.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Mortality; Sprays; Standards; Herbicides; Respiratory diseases; Military; Mortality patterns; Occupational exposure; Cancer; chronic obstructive pulmonary disease; Respiratory system; USA; Vietnam DO - http://dx.doi.org/10.1016/j.annepidem.2010.02.003 ER - TY - JOUR T1 - The war memorial as healing environment: the psychological effect of the Vietnam veterans memorial on Vietnam War combat veterans' posttraumatic stress disorder symptoms AN - 743798914; 3970192 AB - It has been hypothesized that experiences with memorials might reduce trauma-related symptoms. Magazines and scholarly work suggest that the Vietnam Veterans Memorial in Washington, DC, helps Vietnam War veterans overcome combat-related losses. This study tested the memorial's effect on veterans' trauma-related symptoms and identified features of the memorial that impacted symptoms. The longitudinal, quasi-experiment was conducted using standardized measures of posttraumatic stress disorder (PTSD) symptom severity. The study included 62 male Vietnam War combat veterans diagnosed with PTSD. The measures were administered before and after the trip to the memorial. The results showed that the severity of a veteran's symptoms varied by how many times he had visited the memorial before the study. There were distinct links between the memorial's design features and a veteran's experiences of the memorial. The study's results indicated that architects can create effective memorial designs by understanding how memorials facilitate the mourning processes. Reprinted by permission of Sage Publications, Inc. JF - Environment and behavior AU - Watkins, Nicholas AU - Cole, Frances AU - Weidemann, Sue AD - HOK ; United States Department of Veterans Affairs ; Workplace Analysis Consulting, Buffalo Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 351 EP - 375 VL - 42 IS - 3 SN - 0013-9165, 0013-9165 KW - Sociology KW - Veterans KW - Mental illness KW - Vietnam War KW - Mental stress KW - Mourning KW - Mental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743798914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+and+behavior&rft.atitle=The+war+memorial+as+healing+environment%3A+the+psychological+effect+of+the+Vietnam+veterans+memorial+on+Vietnam+War+combat+veterans%27+posttraumatic+stress+disorder+symptoms&rft.au=Watkins%2C+Nicholas%3BCole%2C+Frances%3BWeidemann%2C+Sue&rft.aulast=Watkins&rft.aufirst=Nicholas&rft.date=2010-05-01&rft.volume=42&rft.issue=3&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Environment+and+behavior&rft.issn=00139165&rft_id=info:doi/10.1177%2F0013916510361873 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 8337; 7947 5772 7954; 7951 6220 7954; 7953 7954; 13316 13443 2698; 13291 8072 6099 DO - http://dx.doi.org/10.1177/0013916510361873 ER - TY - JOUR T1 - Portosystemic encephalopathy due to mesoiliac shunt in a patient without cirrhosis. AN - 742787269; pmid-19636259 AB - Hepatic encephalopathy most commonly occurs in patients with cirrhosis and end-stage liver disease, however, the disorder can also occur in the presence of intrahepatic or extrahepatic shunts when the intrahepatic circulation is effectively bypassed. The majority of extrahepatic shunts described to date develop between a mesenteric vein and inferior vena cava. Herein we report a novel case of a superior mesenteric vein to left internal iliac vein shunt that led to hepatic encephalopathy in a 57-year-old woman with no apparent underlying liver disorder. The patient presented with confusion, disorientation, and hyperammonemia. Workup for parenchymal liver disease was negative and liver biopsy findings did not show significant liver disease. Magnetic resonance imaging revealed a serpiginous 1-cm-wide shunt that diverted superior mesenteric vein blood from the portal confluence to the left internal iliac vein. Surgical closure of the shunt led to marked improvement of the patient with the resolution of hepatic encephalopathy. This report is the first description of a portosystemic shunt, likely congenital, linking these 2 vessels resulting in clinically significant hepatic encephalopathy. The findings emphasize that abdominal and pelvic imaging should be considered in patients with signs of hepatic encephalopathy that have none to minimal hepatic disease. JF - Journal of clinical gastroenterology AU - Ali, Sobia AU - Stolpen, Alan H AU - Schmidt, Warren N AD - Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa and Veterans Administration Medical Center, Iowa City, IA 52242, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 381 EP - 383 VL - 44 IS - 5 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Magnetic Resonance Imaging KW - Humans KW - Middle Aged KW - Female KW - Mesenteric Veins -- abnormalities KW - Hepatic Encephalopathy -- surgery KW - Hepatic Encephalopathy -- etiology KW - Hepatic Encephalopathy -- physiopathology KW - Mesenteric Veins -- surgery KW - Iliac Vein -- abnormalities KW - Iliac Vein -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742787269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Portosystemic+encephalopathy+due+to+mesoiliac+shunt+in+a+patient+without+cirrhosis.&rft.au=Ali%2C+Sobia%3BStolpen%2C+Alan+H%3BSchmidt%2C+Warren+N&rft.aulast=Ali&rft.aufirst=Sobia&rft.date=2010-05-01&rft.volume=44&rft.issue=5&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-08-05 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Lessons from HIV therapy applied to viral hepatitis therapy: summary of a workshop. AN - 742782414; pmid-20087331 AB - Therapies for hepatitis B virus (HBV) have continued to evolve, and new therapies for hepatitis C virus (HCV) will soon be available in clinical practice. These medications for hepatitis C will mark the first time that direct antivirals that target HCV functions have been used. When such drugs are used as single agents, previously existing mutants with reduced susceptibility to them are rapidly selected. The relationship between these drug-resistant mutants and "wild-type" virus is unclear, but resistant strains likely have the potential to maintain the progression of liver disease despite successful treatment of "wild-type" virus. Resistant HBV and now HCV are already a clinical problem. The same issue was recognized very early in the development of therapy against HIV, with azidothymidine-resistant mutants detected within the first weeks of therapy. Clinical investigation and a progressive understanding of the pathogenesis of the disease overcame this challenge and led to the substantial and durable benefits of antiretroviral therapy that are evident today. To bring experts from the fields of HIV and viral hepatitis virology and therapy together for interactive discussions about how to apply the lessons from HIV to the further development of viral hepatitis therapy, the American Association for the Study of Liver Diseases held a single-topic conference entitled "Viral Hepatitis Therapy: Lessons to be Learned From HIV" on 24-26 July 2008. This article summarizes that conference. JF - The American journal of gastroenterology AU - Monto, Alexander AU - Schooley, Robert T AU - Lai, Jennifer C AU - Sulkowski, Mark S AU - Chung, Raymond T AU - Pawlotsky, Jean-Michel AU - McHutchison, John G AU - Jacobson, Ira M AD - Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA. alexander.monto@va.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 989 EP - 1004; quiz 988, 1005 VL - 105 IS - 5 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Severity of Illness Index KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Hepatitis C, Chronic -- drug therapy KW - Humans KW - Hepatitis B, Chronic -- diagnosis KW - HIV Infections -- diagnosis KW - Risk Assessment KW - Drug Therapy, Combination KW - Hepatitis C, Chronic -- diagnosis KW - Education KW - Anti-HIV Agents -- therapeutic use KW - Drug Resistance, Viral KW - HIV Infections -- drug therapy KW - Treatment Outcome KW - Follow-Up Studies KW - Female KW - Education, Medical, Continuing KW - Male KW - Hepatitis B, Chronic -- drug therapy KW - Antiviral Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742782414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Lessons+from+HIV+therapy+applied+to+viral+hepatitis+therapy%3A+summary+of+a+workshop.&rft.au=Monto%2C+Alexander%3BSchooley%2C+Robert+T%3BLai%2C+Jennifer+C%3BSulkowski%2C+Mark+S%3BChung%2C+Raymond+T%3BPawlotsky%2C+Jean-Michel%3BMcHutchison%2C+John+G%3BJacobson%2C+Ira+M&rft.aulast=Monto&rft.aufirst=Alexander&rft.date=2010-05-01&rft.volume=105&rft.issue=5&rft.spage=989&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-06-07 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Posttraumatic Stress Disorder and the Genetic Structure of Comorbidity AN - 742728491; 201019203 AB - This study used structural equation modeling to examine the genetic and environmental architecture of latent dimensions of internalizing and externalizing psychiatric comorbidity and explored structural associations between posttraumatic stress disorder (PTSD) and these dimensions. Data were drawn from the Vietnam Era Twin Registry and included lifetime diagnoses for PTSD and a range of other psychiatric disorders for 3,372 male-male twin pairs. Examination of the phenotypic structure of these disorders revealed that PTSD cross-loaded on both Internalizing and Externalizing common factors. Biometric analyses suggested largely distinct genetic risk factors for the latent internalizing and externalizing comorbidity dimensions, with the total heritability of the Externalizing factor (69%) estimated to be significantly stronger than that for Internalizing (41%). Nonshared environment explained the majority of the remaining variance in the Internalizing (58%) and Externalizing (20%) factors. Shared genetic variance across the 2 dimensions explained 67% of their phenotypic correlation (r = .52). These findings have implications for conceptualizations of the etiology of PTSD and its location in an empirically based nosology. [Copyright American Psychological Association] JF - Journal of Abnormal Psychology AU - Wolf, Erika J AU - Miller, Mark W AU - Krueger, Robert F AU - Lyons, Michael J AU - Tsuang, Ming T AU - Koenen, Karestan C AD - National Center for PTSD, VA Boston Healthcare System and Department of Psychology, Boston University Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 320 EP - 330 PB - American Psychological Association, Washington DC VL - 119 IS - 2 SN - 0021-843X, 0021-843X KW - posttraumatic stress disorder structure of comorbidity behavioral genetics structural equation modeling KW - Twins KW - Posttraumatic stress disorder KW - Internalization KW - Externalizing behaviour KW - Comorbidity KW - Vietnam KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742728491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Psychology&rft.atitle=Posttraumatic+Stress+Disorder+and+the+Genetic+Structure+of+Comorbidity&rft.au=Wolf%2C+Erika+J%3BMiller%2C+Mark+W%3BKrueger%2C+Robert+F%3BLyons%2C+Michael+J%3BTsuang%2C+Ming+T%3BKoenen%2C+Karestan+C&rft.aulast=Wolf&rft.aufirst=Erika&rft.date=2010-05-01&rft.volume=119&rft.issue=2&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Psychology&rft.issn=0021843X&rft_id=info:doi/10.1037%2Fa0019035 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JABCAA N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Internalization; Externalizing behaviour; Comorbidity; Twins; Vietnam DO - http://dx.doi.org/10.1037/a0019035 ER - TY - JOUR T1 - How oncologists and their patients with advanced cancer communicate about health-related quality of life AN - 742725835; 201018224 AB - Objective: To describe the content and frequency of communication about health-related quality of life (HRQOL) during outpatient encounters between oncologists and their patients with advanced cancer. Methods: We coded for HRQOL talk in a subset of audio-recorded conversations (each previously found to contain prognostic talk by the oncologist) from the Study of Communication in Oncologist-Patient Encounters Trial, a randomized controlled trial conducted from 2003 to 2008 in two large US academic medical centers and one Veterans Affairs Medical Center. Results: Seventy-three encounters involved 70 patients and 37 oncologists. Patients were more likely to be female (53%), White (86%), married (78%), and possessing some college education (62%). Most oncologists were male (78%) and White (78%). Mean ages were 59 years for patients and 44 years for oncologists. Every encounter included some talk about HRQOL and HRQOL discussions made up, on average, 25% of the visit time. HRQOL segments described symptoms (50%), general HRQOL (27%), and the following concerns: physical (27%), functional (22%), psychological (9%), social (7%), spiritual (1%), and other (28%). Topics included treatment (56%), disease (14%), and testing (3%), and conversations focused on past (44%), present (68%), and future HRQOL (59%). Conclusions: HRQOL discussions between oncologists and patients are common, but the emphasis is often on treatment (e.g. side effects) and symptoms (e.g. pain) even in patients with advanced disease. Given the often intense emotional experience of patients with advanced cancer, oncologists may need to pay more attention to psychological, social, and spiritual HRQOL concerns. [Copyright John Wiley and Sons, Ltd.] JF - Psycho-Oncology AU - Rodriguez, Keri L AU - Bayliss, Nichole AU - Alexander, Stewart C AU - Jeffreys, Amy S AU - Olsen, Maren K AU - Pollak, Kathryn I AU - Kennifer, Sarah L AU - Tulsky, James A AU - Arnold, Robert M AD - Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA Keri.rodriguez@va.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 490 EP - 499 PB - John Wiley, Chichester UK VL - 19 IS - 5 SN - 1057-9249, 1057-9249 KW - Symptoms KW - Health status KW - Side effects KW - Terminally ill people KW - Oncologists KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742725835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=How+oncologists+and+their+patients+with+advanced+cancer+communicate+about+health-related+quality+of+life&rft.au=Rodriguez%2C+Keri+L%3BBayliss%2C+Nichole%3BAlexander%2C+Stewart+C%3BJeffreys%2C+Amy+S%3BOlsen%2C+Maren+K%3BPollak%2C+Kathryn+I%3BKennifer%2C+Sarah+L%3BTulsky%2C+James+A%3BArnold%2C+Robert+M&rft.aulast=Rodriguez&rft.aufirst=Keri&rft.date=2010-05-01&rft.volume=19&rft.issue=5&rft.spage=490&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/10.1002%2Fpon.1579 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - CODEN - POJCEE N1 - SubjectsTermNotLitGenreText - Quality of life; Health status; Oncologists; Terminally ill people; Symptoms; Side effects DO - http://dx.doi.org/10.1002/pon.1579 ER - TY - JOUR T1 - Patient exit interviews for assessing fidelity to the VA VISN 2 Integrated Primary Care Model: Results from a pilot feasibility study AN - 742725584; 201015062 AB - Abstract not available. JF - Journal of Interprofessional Care AU - Beehler, Gregory P AU - Finnell, Deborah S AU - Foltz, Kelly AU - Edwards, Dawn AD - VA VISN 2 Center for Integrated Healthcare gregory.beehler@va.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 323 EP - 326 PB - Taylor & Francis, Abingdon UK VL - 24 IS - 3 SN - 1356-1820, 1356-1820 KW - Feasibility KW - Fidelity KW - Primary health care KW - Exit interviews KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742725584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interprofessional+Care&rft.atitle=Patient+exit+interviews+for+assessing+fidelity+to+the+VA+VISN+2+Integrated+Primary+Care+Model%3A+Results+from+a+pilot+feasibility+study&rft.au=Beehler%2C+Gregory+P%3BFinnell%2C+Deborah+S%3BFoltz%2C+Kelly%3BEdwards%2C+Dawn&rft.aulast=Beehler&rft.aufirst=Gregory&rft.date=2010-05-01&rft.volume=24&rft.issue=3&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interprofessional+Care&rft.issn=13561820&rft_id=info:doi/10.3109%2F13561820902921894 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - CODEN - JINCFT N1 - SubjectsTermNotLitGenreText - Fidelity; Primary health care; Feasibility; Exit interviews DO - http://dx.doi.org/10.3109/13561820902921894 ER - TY - JOUR T1 - Personal, Medical, and Healthcare Utilization Among Homeless Veterans Served by Metropolitan and Nonmetropolitan Veteran Facilities AN - 742713130; 201016191 AB - This study assessed differences in personal, medical, and health care utilization characteristics of homeless veterans living in metropolitan versus nonmetropolitan environments. Data were obtained from a Veterans Health Administration (VHA) network sample of homeless veterans. Chi-square tests were used to assess differences in demographics, military history, living situation, medical history, employment status, and health care utilization. Moderator analyses determined whether predictors of health care utilization varied by metropolitan status. Of 3,595 respondents, 60% were residing in metropolitan areas. Age, sex, and marital status were similar between metropolitan and nonmetropolitan homeless. Metropolitan homeless were less likely to receive public financial support or to be employed, to have at least one medical problem, one psychiatric problem, or current alcohol dependency, but more likely to be homeless longer. Of the 52% of the sample who used VHA care in the last 6 months, 53% were metropolitan versus 49% nonmetropolitan (p = .01). Metropolitan status predicted at least one VHA visit within the prior 6 months (OR:1.3, CI:1.1, 1.6). Significant differences occur in the personal, medical, and health care utilization characteristics of homeless veterans in metropolitan versus nonmetropolitan areas. [Copyright Elsevier B.V.] JF - Psychological Services AU - Gordon, Adam J AU - Haas, Gretchen L AU - Luther, James F AU - Hilton, Michael T AU - Goldstein, Gerald AD - Mental Illness Research, Education, and Clinical Center and Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, and University of Pittsburgh School of Medicine adam.gordon@va.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 65 EP - 74 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 7 IS - 2 SN - 1541-1559, 1541-1559 KW - homelessness rural health veterans health services research KW - Veterans KW - Homeless people KW - Moderators KW - Chi-Square Test KW - Dependency KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742713130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Personal%2C+Medical%2C+and+Healthcare+Utilization+Among+Homeless+Veterans+Served+by+Metropolitan+and+Nonmetropolitan+Veteran+Facilities&rft.au=Gordon%2C+Adam+J%3BHaas%2C+Gretchen+L%3BLuther%2C+James+F%3BHilton%2C+Michael+T%3BGoldstein%2C+Gerald&rft.aulast=Gordon&rft.aufirst=Adam&rft.date=2010-05-01&rft.volume=7&rft.issue=2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0018479 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Homeless people; Helpseeking; Veterans; Chi-Square Test; Dependency; Moderators DO - http://dx.doi.org/10.1037/a0018479 ER - TY - CPAPER T1 - Improved Survival of Hepatocellular Carcinoma (Hcc) in Hiv-Infected Patients with Undetectable Hiv Rna T2 - 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) AN - 754271854; 5830669 JF - 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) AU - Brau, N AU - Kikuchi, L AU - Nunez, M AU - Barreiro, P AU - Nelson, M AU - Bini, E AU - Kristen, M AU - Fox, R AU - Sherman, M AU - Puoti, M Y1 - 2010/04/14/ PY - 2010 DA - 2010 Apr 14 KW - Human immunodeficiency virus KW - Survival KW - RNA KW - Hepatocellular carcinoma KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754271854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver+%28EASL+2010%29&rft.atitle=Improved+Survival+of+Hepatocellular+Carcinoma+%28Hcc%29+in+Hiv-Infected+Patients+with+Undetectable+Hiv+Rna&rft.au=Brau%2C+N%3BKikuchi%2C+L%3BNunez%2C+M%3BBarreiro%2C+P%3BNelson%2C+M%3BBini%2C+E%3BKristen%2C+M%3BFox%2C+R%3BSherman%2C+M%3BPuoti%2C+M&rft.aulast=Brau&rft.aufirst=N&rft.date=2010-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver+%28EASL+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/easl2010/orals/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Depression Symptoms and Treatment Among HIV Infected and Uninfected Veterans AN - 758126667; 201010657 AB - Depression is one of the most common comorbid conditions affecting persons with HIV. We compared depressive symptoms and depression treatment using data from the Veterans Aging Cohort Study (VACS), a prospective cohort of HIV-infected and uninfected subjects. We identified subjects with a Patient Health Questionnaire score of 10 or greater. Treatment was defined as prescription of a selective serotonin reuptake inhibitor (SSRI) or mental health counseling. Overall, 16% of 4,480 subjects had depressive symptoms, and HIV-infected patients were more likely to have had depressive symptoms (OR=1.38, 95% CI=1.18, 1.62). Geographic site of care and having a mental health provider at the clinic was associated with treatment. In multivariable models restricted to 732 patients with depressive symptoms, receipt of depression treatment did not differ by HIV status (Adjusted OR=1.11, 95% CI=0.80, 1.54). Non-Hispanic whites were more likely to receive treatment (Adjusted OR=2.09, 95% CI 1.04, 4.24). Primary care and HIV providers were equally unlikely to treat active depressive symptoms. Treatment variation by race, site, and availability of a mental health provider, suggests targets for intervention. Adapted from the source document. JF - AIDS and Behavior AU - Sueoka, Kristen AU - Goulet, Joseph L AU - Fiellin, David A AU - Rimland, David AU - Butt, Adeel A AU - Gibert, Cynthia AU - Rodriguez-Barradas, Maria C AU - Bryant, Kendall AU - Crystal, Stephen AU - Justice, Amy C AD - Yale University School of Medicine, New Haven, CT, USA Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 272 EP - 279 PB - Springer, Dordrecht, The Netherlands VL - 14 IS - 2 SN - 1090-7165, 1090-7165 KW - Whites KW - Veterans KW - Depression (Psychology) KW - Acquired Immune Deficiency Syndrome KW - Aging KW - Intervention KW - Primary Health Care KW - Patients KW - Mental Health Services KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758126667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Depression+Symptoms+and+Treatment+Among+HIV+Infected+and+Uninfected+Veterans&rft.au=Sueoka%2C+Kristen%3BGoulet%2C+Joseph+L%3BFiellin%2C+David+A%3BRimland%2C+David%3BButt%2C+Adeel+A%3BGibert%2C+Cynthia%3BRodriguez-Barradas%2C+Maria+C%3BBryant%2C+Kendall%3BCrystal%2C+Stephen%3BJustice%2C+Amy+C&rft.aulast=Sueoka&rft.aufirst=Kristen&rft.date=2010-04-01&rft.volume=14&rft.issue=2&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-008-9428-7 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Depression (Psychology); Acquired Immune Deficiency Syndrome; Patients; Veterans; Mental Health Services; Primary Health Care; Intervention; Whites; Aging DO - http://dx.doi.org/10.1007/s10461-008-9428-7 ER - TY - JOUR T1 - A Random Effects Multinomial Logit Analysis of Using Medicare and VA Healthcare Among Veterans With Dementia AN - 758125894; 201010985 AB - This study aimed to examine longitudinal patterns of VA-only use, dual VA and Medicare use, or Medicare-only use among veterans with dementia. Data on VA and Medicare use (1998-2001) were obtained from VA administrative datasets and Medicare claims for 2,137 male veterans with a formal diagnosis of Alzheimer's disease or vascular dementia enrolled in the National Longitudinal Caregiver Study. A random effects multinomial logit model accounting for unobserved individual heterogeneity was used to estimate the effects of patient and caregiver characteristics on use group over time. Compared to VA-only use, dual VA and Medicare use was associated with being white, married, higher education, having private insurance, Medicaid, low VA priority level, more functional limitations, and having lived in a nursing home or died in that year. Medicare-only use was associated with older age, being married, higher education, having private insurance, low VA priority level, living further from a VA Medical Center, having more comorbidities, functional limitations, and having lived in a nursing home or died. Veterans whose caregivers reported better health were more likely to be dual users, but those whose caregivers reported more comorbidities were more likely to use Medicare only. Different aspects of veterans' needs and caregiver characteristics have differential effect on where veterans seek care. Efforts to coordinate care between VA and Medicare providers are necessary to ensure patients receive high quality care. Adapted from the source document. JF - Home Health Care Services Quarterly AU - Zhu, Carolyn W AU - Livote, Elayne E AU - Ross, Joseph S AU - Penrod, Joan D AD - James J. Peters Veterans Administration Medical Center, Bronx, and Mount Sinai School of Medicine, New York, New York, USA Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 91 EP - 104 PB - Taylor & Francis, Philadelphia PA VL - 29 IS - 2 SN - 0162-1424, 0162-1424 KW - Whites KW - Veterans KW - Males KW - Senility KW - Patients KW - Higher Education KW - Nursing Homes KW - Comorbidity KW - Health Care Services KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758125894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Home+Health+Care+Services+Quarterly&rft.atitle=A+Random+Effects+Multinomial+Logit+Analysis+of+Using+Medicare+and+VA+Healthcare+Among+Veterans+With+Dementia&rft.au=Zhu%2C+Carolyn+W%3BLivote%2C+Elayne+E%3BRoss%2C+Joseph+S%3BPenrod%2C+Joan+D&rft.aulast=Zhu&rft.aufirst=Carolyn&rft.date=2010-04-01&rft.volume=29&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Home+Health+Care+Services+Quarterly&rft.issn=01621424&rft_id=info:doi/10.1080%2F01621424.2010.493771 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 37 N1 - Last updated - 2016-09-28 N1 - CODEN - HHCQDJ N1 - SubjectsTermNotLitGenreText - Veterans; Senility; Comorbidity; Nursing Homes; Higher Education; Patients; Health Care Services; Males; Whites DO - http://dx.doi.org/10.1080/01621424.2010.493771 ER - TY - JOUR T1 - Innate immune recognition of, and response to, Clostridium sordellii AN - 746009270; 13004885 AB - Clostridium sordellii, an anaerobic pathogen, has recently been associated with rapidly fatal infections following medically induced abortions and injecting drug use. Patients with C. sordellii infection display few signs of inflammation such as fever, or redness and pain at the site of infection. We hypothesized that this could be due to reduced recognition of the organism by Toll-like receptors (TLRs) of the innate immune system. An ELAM-NF- Kappa B luciferase reporter system in TLR-transfected HEK cells was used to measure TLR-dependent recognition of washed, heat-killed C. sordellii and other pathogenic clostridial species. Results demonstrated that all clostridia were well recognized by TLR2 alone and that responses were greatest when TLR2 was co-expressed with TLR6. Further, isolated human monocytes produced the pro-inflammatory cytokine TNFa and the immunoregulator IL-10 in response to C. sordellii. In addition, C. sordellii-stimulated monocytes produced 30% less TNFa following treatment with an anti-TLR2 blocking antibody. These data demonstrate that innate immune recognition of, and response to, cell-associated components of C. sordellii and other clostridial pathogens are mediated by TLR2 in combination with TLR6. We conclude that the characteristic absence of inflammatory signs and symptoms in C. sordellii infection is not related to inadequate immune detection of the organism, but rather is attributable to a species-specific immune system dysfunction that remains to be elucidated. JF - Anaerobe AU - Aldape, MJ AU - Bryant, A E AU - Katahira, E J AU - Hajjar, A M AU - Finegold, S M AU - Ma, Y AU - Stevens, D L AD - Veterans Affairs Medical Center, Infectious Diseases Section, 500 West Fort St. (Bldg 45), Boise, ID 83702, USA, mike.aldape@va.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 125 EP - 130 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 16 IS - 2 SN - 1075-9964, 1075-9964 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Abortion KW - Clostridium sordellii KW - Toll-like receptors KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746009270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Innate+immune+recognition+of%2C+and+response+to%2C+Clostridium+sordellii&rft.au=Aldape%2C+MJ%3BBryant%2C+A+E%3BKatahira%2C+E+J%3BHajjar%2C+A+M%3BFinegold%2C+S+M%3BMa%2C+Y%3BStevens%2C+D+L&rft.aulast=Aldape&rft.aufirst=MJ&rft.date=2010-04-01&rft.volume=16&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=10759964&rft_id=info:doi/10.1016%2Fj.anaerobe.2009.06.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Toll-like receptors; Clostridium sordellii DO - http://dx.doi.org/10.1016/j.anaerobe.2009.06.004 ER - TY - JOUR T1 - Significantly Larger Numbers of Methicillin-Resistant Staphylococcus aureus Bacteria Are Recovered from Polymicrobial Respiratory and Wound Sites by Use of Chromogenic Primary Media than by Use of Conventional Culture AN - 746004418; 12581160 AB - Previous studies have validated the properties and documented the utility of chromogenic agar for surveillance of methicillin-resistant Staphylococcus aureus (MRSA). In this study, we used one of the chromagars, MRSASelect (Bio-Rad), as one of the primary isolation media for selected wound and respiratory clinical specimens which, in our institution, were typically polymicrobial. We examined a total of 638 specimens; 142 (22%) MRSA isolates were recovered. Twenty-six of these isolates were recovered only on the MRSASelect plate, representing a 28% (15/54) increase for endotracheal aspirates/sputa and a 15% increase for superficial wounds/ulcers (11/73) compared to the results with conventional culture. One isolate (1 CFU) was recovered by conventional medium alone. MRSASelect has generally been used for surveillance cultures; however, we document that an additional 21% of MRSA isolates would have gone unreported in these selected clinical specimens using only standard culture media. For 40% (6/15) of inpatients, MRSA isolated from the MRSASelect plate was the sole indicator of MRSA. Although these isolates can represent either colonization or infection, they are a potential reservoir of infection and nosocomial transmission. Our data support the focused use of chromogenic selective media for the increased detection of MRSA in polymicrobial wound and respiratory specimens, which could have an impact on both clinical treatment and infection control. JF - Journal of Clinical Microbiology AU - Harrington, Amanda T AU - Mahlen, Steven D AU - Clarridge III, Jill E AD - Puget Sound Health Care System, Seattle, Washington, jill.clarridge@va.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 1350 EP - 1353 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 48 IS - 4 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Agar KW - Data processing KW - Drug resistance KW - Infection KW - Media (selective) KW - Wounds KW - Colonization KW - Ulcers KW - Colony-forming cells KW - Staphylococcus aureus KW - Media (culture) KW - Media (isolation) KW - Hospitals KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746004418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Significantly+Larger+Numbers+of+Methicillin-Resistant+Staphylococcus+aureus+Bacteria+Are+Recovered+from+Polymicrobial+Respiratory+and+Wound+Sites+by+Use+of+Chromogenic+Primary+Media+than+by+Use+of+Conventional+Culture&rft.au=Harrington%2C+Amanda+T%3BMahlen%2C+Steven+D%3BClarridge+III%2C+Jill+E&rft.aulast=Harrington&rft.aufirst=Amanda&rft.date=2010-04-01&rft.volume=48&rft.issue=4&rft.spage=1350&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.01770-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 15 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Agar; Colonization; Data processing; Ulcers; Colony-forming cells; Drug resistance; Infection; Media (selective); Media (isolation); Media (culture); Hospitals; Wounds; Staphylococcus aureus DO - http://dx.doi.org/10.1128/JCM.01770-09 ER - TY - JOUR T1 - Phase 1/2 study of preoperative docetaxel and mitoxantrone for high-risk prostate cancer AN - 746001247; 12746405 AB - BACKGROUND: A study was conducted to determine the 5-year recurrence-free survival in patients with high-risk prostate cancer after neoadjuvant combination chemotherapy followed by surgery. Secondary endpoints included safety, pathologic effects of chemotherapy, and predictors of disease recurrence. METHODS: Fifty-seven patients were enrolled in a phase 1/2 study of weekly docetaxel 35 mg/m2 and escalating mitoxantrone to 4 mg/m2 before prostatectomy. Patients were treated with 16 weeks of chemotherapy administered weekly on a 3 of every 4 week schedule. A tissue microarray, constructed from the prostatectomy specimens, served to facilitate the exploratory evaluation of biomarkers. The primary endpoint was recurrence-free survival. Disease recurrence was defined as a confirmed serum prostate-specific antigen (PSA) >0.4 ng/mL. RESULTS: Of the 57 patients, 54 received 4 cycles of docetaxel and mitoxantrone before radical prostatectomy. Grade 4 toxicities were limited to leukopenia, neutropenia, and hyperglycemia. Serum testosterone levels remained stable after chemotherapy. Negative surgical margins were attained in 67% of cases. Lymph node involvement was detected in 18.5% of cases. With a median follow-up of 63 months, 27 of 57 (47.4%) patients recurred. The Kaplan-Meier recurrence-free survival at 2 years was 65.5% (95% confidence interval [CI], 53.0%-78.0%) and was 49.8% at 5 years (95% CI, 35.5%-64.1%). Pretreatment serum PSA, lymph node involvement, and postchemotherapy tissue vascular endothelial growth factor expression were independent predictors of early recurrence. CONCLUSIONS: Preoperative chemotherapy with docetaxel and mitoxantrone is feasible. Approximately half of the high-risk patients remain free of disease recurrence at 5 years, and clinical and molecular predictors of early recurrence were identified. Cancer 2010. JF - Cancer AU - Garzotto, Mark AU - Higano, Celestia S AU - O'Brien, Catherine AU - Rademacher, Brooks L S AU - Janeba, Nicole AU - Fazli, Ladan AU - Lange, Paul H AU - Lieberman, Stephen AU - Beer, Tomasz M AD - Division of Urology, Oregon Health and Science University, Portland Veterans Administration Medical Center, Portland, Oregon, beert@ohsu.edu Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 1699 EP - 1708 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 116 IS - 7 SN - 0008-543X, 0008-543X KW - Risk Abstracts KW - Bioindicators KW - lymph nodes KW - Toxicity KW - survival KW - prostate cancer KW - growth factors KW - chemotherapy KW - Cancer KW - surgery KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746001247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Phase+1%2F2+study+of+preoperative+docetaxel+and+mitoxantrone+for+high-risk+prostate+cancer&rft.au=Garzotto%2C+Mark%3BHigano%2C+Celestia+S%3BO%27Brien%2C+Catherine%3BRademacher%2C+Brooks+L+S%3BJaneba%2C+Nicole%3BFazli%2C+Ladan%3BLange%2C+Paul+H%3BLieberman%2C+Stephen%3BBeer%2C+Tomasz+M&rft.aulast=Garzotto&rft.aufirst=Mark&rft.date=2010-04-01&rft.volume=116&rft.issue=7&rft.spage=1699&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24960 L2 - http://www3.interscience.wiley.com/journal/123276778/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Bioindicators; lymph nodes; Toxicity; prostate cancer; survival; growth factors; surgery; Cancer; chemotherapy DO - http://dx.doi.org/10.1002/cncr.24960 ER - TY - JOUR T1 - A Pilot Study Investigating the Effects of Trauma, Experiential Avoidance, and Disease Management in HIV-Positive MSM Using Methamphetamine AN - 745635024; 12953750 AB - With high rates of trauma among HIV-positive men who have sex with men (MSM) who use methamphetamine, this preliminary pilot study examined the associations between experiential avoidance, trauma symptoms, and management of a chronic illness. Among a small sample of HIV-positive, methamphetamine-using MSM in a California Bay Area County, greater reported experiential avoidance was significantly related to greater reported trauma and symptoms of traumatic stress. Furthermore, greater reported experiential avoidance was significantly related to reduced self-efficacy of illness management and more frequent methamphetamine use. Although further research is needed, these data suggest that addressing issues of experiential avoidance and trauma could affect behavioral choices and treatment outcomes in this high-risk population. JF - Journal of the International Association of Physicians in AIDS Care (JIAPAC) AU - Chartier, Maggie AU - Vinatieri, Trisha AU - DeLonga, Kathryn AU - McGlynn, Lawrence M AU - Gore-Felton, Cheryl AU - Koopman, Cheryl AD - Pacific Graduate School of Psychology-Stanford Psy.D. Consortium, CA, USA, maggie.chartier@va.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 78 EP - 81 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 9 IS - 2 SN - 1545-1097, 1545-1097 KW - Virology & AIDS Abstracts; Risk Abstracts KW - HIV/AIDS KW - MSM KW - methamphetamine KW - trauma KW - experiential avoidance KW - Acquired immune deficiency syndrome KW - Data processing KW - homosexuality KW - Stress KW - Trauma KW - Methamphetamine KW - Human immunodeficiency virus KW - INE, USA, California KW - Risk groups KW - Sex KW - V 22360:AIDS and HIV KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745635024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Association+of+Physicians+in+AIDS+Care+%28JIAPAC%29&rft.atitle=A+Pilot+Study+Investigating+the+Effects+of+Trauma%2C+Experiential+Avoidance%2C+and+Disease+Management+in+HIV-Positive+MSM+Using+Methamphetamine&rft.au=Chartier%2C+Maggie%3BVinatieri%2C+Trisha%3BDeLonga%2C+Kathryn%3BMcGlynn%2C+Lawrence+M%3BGore-Felton%2C+Cheryl%3BKoopman%2C+Cheryl&rft.aulast=Chartier&rft.aufirst=Maggie&rft.date=2010-04-01&rft.volume=9&rft.issue=2&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Association+of+Physicians+in+AIDS+Care+%28JIAPAC%29&rft.issn=15451097&rft_id=info:doi/10.1177%2F1545109709360065 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 28 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Methamphetamine; Data processing; Stress; Risk groups; Sex; Trauma; Acquired immune deficiency syndrome; homosexuality; methamphetamine; Human immunodeficiency virus; INE, USA, California DO - http://dx.doi.org/10.1177/1545109709360065 ER - TY - JOUR T1 - Doing Hegemony: Military, Men, and Constructing A Hegemonic Masculinity AN - 743061624; 201046020 AB - Hegemonic masculinities are at the top of the gender hierarchy and exist in relation to subordinated gender constructs. Traditional constructions of hegemonic masculinities include risk-taking, self-discipline, physical toughness and/or muscular development, aggression, violence, emotional control, and overt heterosexual desire. Using a grounded theory approach, 43 men were interviewed focusing on the process of hegemonic masculinities construction (n = 25 pre-active duty Reserve Officer Training Corps members and n = 18 Delayed Entry Program men). By casting non-military personal (i.e., civilians) and service members of different branches (i.e., Army, Navy, Marines, Air Force), different occupational specialties (i.e., infantry, artillery, supply, etc.), and different rank (officer versus enlisted) as less physically able, self-disciplined, willing to take risks, emotionally controlled, and/or intelligent, pre-active duty servicemen discursively dominate others. The end result is that men create hierarchies that subordinate others while simultaneously placing their own perceived characteristics in positions of symbolic dominance. Adapted from the source document. JF - The Journal of Men's Studies AU - Hinojosa, Ramon AD - Rehabilitation Outcomes Research Center, North Florida/South Georgia Veterans Health System, 1601 SW Archer Road (151B), Gainesville, FL 32608 Ramon.Hinojosa@va.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 179 EP - 194 PB - Men's Studies Press, Harriman, TN VL - 18 IS - 2 SN - 1060-8265, 1060-8265 KW - masculinities, gender, identity, discourse, military KW - Masculinity KW - Hegemony KW - Males KW - Heterosexuality KW - Aggression KW - Sex KW - article KW - 2983: feminist/gender studies; sociology of gender & gender relations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743061624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Men%27s+Studies&rft.atitle=Doing+Hegemony%3A+Military%2C+Men%2C+and+Constructing+A+Hegemonic+Masculinity&rft.au=Hinojosa%2C+Ramon&rft.aulast=Hinojosa&rft.aufirst=Ramon&rft.date=2010-04-01&rft.volume=18&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Men%27s+Studies&rft.issn=10608265&rft_id=info:doi/10.3149%2Fjms.1802.179 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-07-12 N1 - Number of references - 48 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Hegemony; Males; Masculinity; Sex; Aggression; Heterosexuality DO - http://dx.doi.org/10.3149/jms.1802.179 ER - TY - JOUR T1 - Judgments of intensity for brief sequences. AN - 742784192; pmid-20369985 AB - The ability to make intensity judgments for sequential stimuli was examined with an intensity-discrimination task involving three 50-ms noise bursts with non-overlapping frequency ranges. Targets (single bursts) presented in three-burst sequences were required to be as much as 5 dB more intense than targets presented as single bursts in isolation, especially for the later targets. Randomizing target position in the sequence did not reliably reduce performance, nor were thresholds for younger and older listeners reliably different. These increases in increment detection threshold are indications of a specific intensity-processing deficit for stimuli occurring later in a sequence. JF - The Journal of the Acoustical Society of America AU - Gallun, Frederick J AD - VA RR&D National Center for Rehabilitative Auditory Research, Portland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, USA. frederick.gallun@va.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - EL166 EP - EL171 VL - 127 IS - 4 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Age Factors KW - Auditory Threshold KW - Audiometry, Pure-Tone KW - Humans KW - Adult KW - Middle Aged KW - Acoustic Stimulation KW - Time Factors KW - Male KW - Judgment KW - Signal Detection, Psychological KW - Speech Intelligibility KW - Pitch Discrimination KW - Perceptual Masking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742784192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Judgments+of+intensity+for+brief+sequences.&rft.au=Gallun%2C+Frederick+J&rft.aulast=Gallun&rft.aufirst=Frederick&rft.date=2010-04-01&rft.volume=127&rft.issue=4&rft.spage=EL166&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-07-08 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - When Horror and Loss Intersect: Traumatic Experiences and Traumatic Bereavement AN - 742729110; 201015761 AB - Members of the clergy serve on the front lines as caregivers for individuals whose lives have been forever changed by life-threatening traumatic events, and by the sudden traumatic deaths of loved ones. This article is intended to provide useful information to clergy about the nature of traumatic experiences, predictable human reactions to them, and ways that clergy can be helpful in restoring psychological and spiritual equilibrium among their service recipients when bad things happen to good people. We first review several types of traumatic events, making a distinction between natural disasters and those that involve human perpetration. Next, two common pathologic reactions, PTSD and complicated or prolonged grief, are described. Current theoretical models for the disorders are discussed, along with description of the intersection of the two disorders. We then present aspects of spirituality as key resources in recovery from traumatic exposure and loss, emphasizing their role in making meaning of tragic experiences. Finally, key principles for clergy to follow in providing psychological first aid to those in crisis after a traumatic experience are discussed. Adapted from the source document. JF - Pastoral Psychology AU - Drescher, Kent AU - Foy, David W AD - National Center for PTSD, VA Palo Alto Health Care System, 795 Willow Rd., Menlo Park, CA 94025, USA kent.drescher@va.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 147 EP - 158 PB - Springer Science+Business Media, Inc, New York, NY VL - 59 IS - 2 SN - 0031-2789, 0031-2789 KW - Posttraumatic stress disorder KW - Traumatic life events KW - Spirituality KW - Clergy KW - Grief KW - First aid KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742729110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pastoral+Psychology&rft.atitle=When+Horror+and+Loss+Intersect%3A+Traumatic+Experiences+and+Traumatic+Bereavement&rft.au=Drescher%2C+Kent%3BFoy%2C+David+W&rft.aulast=Drescher&rft.aufirst=Kent&rft.date=2010-04-01&rft.volume=59&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Pastoral+Psychology&rft.issn=00312789&rft_id=info:doi/10.1007%2Fs11089-009-0262-2 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Traumatic life events; Clergy; First aid; Spirituality; Grief; Posttraumatic stress disorder DO - http://dx.doi.org/10.1007/s11089-009-0262-2 ER - TY - JOUR T1 - A Longitudinal Analysis of Rural and Urban Veterans' Health-Related Quality of Life AN - 742725782; 201014634 AB - Context: Cross-sectional studies have identified rural-urban disparities in veterans' health-related quality-of-life (HRQOL) scores. Purpose: To determine whether longitudinal analyses confirmed that these disparities in veterans' HRQOL scores persisted. Methods: We obtained data from the SF-12 portion of the veterans health administration's (VA's) Survey of Healthcare Experiences of Patients (SHEP) collected between 2002 and 2006. During that time, the SHEP was randomly administered to approximately 250,000 veterans annually who had used VA outpatient services. We evaluated 163,709 responses from veterans who had completed 2 or more surveys during the years studied. Respondents were classified into rural-urban groups using ZIP Code-based rural-urban commuting area designations. We estimated linear regression models using generalized estimating equations to determine whether rural and urban veterans' HRQOL scores were changing at different rates over the time period examined. Findings: After adjustment for sociodemographic differences, we found that urban veterans had substantially better physical HRQOL scores than their rural counterparts and that these differences persisted over the study period. While urban veterans had worse mental HRQOL scores than rural veterans, those differences diminished over the time period studied. Conclusions: Rural-urban disparities in HRQOL scores persist when tracking veterans longitudinally. Reduced access among rural veterans to care may contribute to these disparities. Because rural soldiers are overrepresented in current conflicts, the VA should consider new models of care delivery to improve access to care for rural veterans. Adapted from the source document. JF - The Journal of Rural Health AU - Wallace, Amy E AU - Lee, Richard AU - MacKenzie, Todd A AU - West, Alan N AU - Wright, Steven AU - Booth, Brenda M AU - Hawthorne, Kara AU - Weeks, William B AD - Veterans Administration Medical Center, White River Junction, Vermont Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 156 EP - 163 PB - National Rural Health Association, Kansas City MO VL - 26 IS - 2 SN - 0890-765X, 0890-765X KW - Rural-Urban differences KW - Veterans KW - Health inequalities KW - Health status KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742725782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health&rft.atitle=A+Longitudinal+Analysis+of+Rural+and+Urban+Veterans%27+Health-Related+Quality+of+Life&rft.au=Wallace%2C+Amy+E%3BLee%2C+Richard%3BMacKenzie%2C+Todd+A%3BWest%2C+Alan+N%3BWright%2C+Steven%3BBooth%2C+Brenda+M%3BHawthorne%2C+Kara%3BWeeks%2C+William+B&rft.aulast=Wallace&rft.aufirst=Amy&rft.date=2010-04-01&rft.volume=26&rft.issue=2&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2010.00277.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JRHEEX N1 - SubjectsTermNotLitGenreText - Veterans; Quality of life; Rural-Urban differences; Health status; Health inequalities DO - http://dx.doi.org/10.1111/j.1748-0361.2010.00277.x ER - TY - JOUR T1 - The Role of Psychologists in the Care of Iraq and Afghanistan Veterans in Primary Care Settings AN - 742724267; 201013820 AB - Although military personnel serving in Iraq and Afghanistan are at high risk of developing mental health problems, many report significant barriers to care and few seek help. Integrated primary care is a comprehensive model of health care that aims to improve access to care and provides a framework to assess and meet the complex psychiatric needs of newly returning veterans by embedding mental health specialists within primary care. We describe the role of psychologists in a Department of Veterans Affairs (VA) integrated primary care clinic that serves veterans of Iraq and Afghanistan. Psychologists based in primary care can assist veterans with reintegration to civilian life by providing rapid mental health assessment, normalizing re-adjustment concerns, planning for veterans' safety, implementing brief interventions within primary care, facilitating transition to additional mental health care, and informing veterans of other available psychosocial services. A case example demonstrating the psychologist's role highlights the benefits of an integrated care model. Implications of employing this model include reduction of symptoms and impairment by reducing stigma and barriers to seeking mental health care, increased motivation to engage in treatment, and implementation of early interventions. This model may also be beneficial in the civilian health care sector with groups that are at high risk for mental health problems, yet experience barriers to care, particularly stigma. [Copyright Elsevier B.V.] JF - Professional Psychology: Research and Practice AU - Maguen, Shira AU - Cohen, Greg AU - Cohen, Beth E AU - Lawhon, G Dawn AU - Marmar, Charles R AU - Seal, Karen H AD - San Francisco VA Medical Center shira.maguen@va.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 135 EP - 142 PB - American Psychological Association, Washington DC VL - 41 IS - 2 SN - 0735-7028, 0735-7028 KW - integrated care veterans mental health post-traumatic stress disorder health care KW - Veterans KW - Stigmatization KW - Mental health care KW - Posttraumatic stress disorder KW - Primary health care KW - Afghanistan KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742724267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Psychology%3A+Research+and+Practice&rft.atitle=The+Role+of+Psychologists+in+the+Care+of+Iraq+and+Afghanistan+Veterans+in+Primary+Care+Settings&rft.au=Maguen%2C+Shira%3BCohen%2C+Greg%3BCohen%2C+Beth+E%3BLawhon%2C+G+Dawn%3BMarmar%2C+Charles+R%3BSeal%2C+Karen+H&rft.aulast=Maguen&rft.aufirst=Shira&rft.date=2010-04-01&rft.volume=41&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Professional+Psychology%3A+Research+and+Practice&rft.issn=07357028&rft_id=info:doi/10.1037%2Fa0018835 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-06-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Veterans; Primary health care; Afghanistan; Posttraumatic stress disorder; Mental health care; Stigmatization DO - http://dx.doi.org/10.1037/a0018835 ER - TY - JOUR T1 - Feasibility of Discussing End-of-Life Care Goals with Inpatients Using a Structured, Conversational Approach: The Go Wish Card Game AN - 742720594; 201013695 AB - Establishing goals of care is important in advance care planning. However, such discussions require a significant time investment on the part of trained personnel and may be overwhelming for the patient. The Go Wish card game was designed to allow patients to consider the importance of common issues at the end of life in a nonconfrontational setting. By sorting through their values in private, patients may present to their provider ready to have a focused conversation about end-of-life care. We evaluated the feasibility of using the Go Wish card game with seriously ill patients in the hospital. Of 133 inpatients approached, 33 (25%) were able to complete the game. The 'top 10' values were scored based on frequency and adjusted for rank. The value selected of highest importance by the most subjects was 'to be free from pain.' Other highly ranked values concerned spirituality, maintaining a sense of self, symptom management, and establishing a strong relationship with health care professionals. Average time to review the patient's rank list after the patient sorted their values in private was 21.8 minutes (range: 6-45 minutes). The rankings from the Go Wish game are similar to those from other surveys of seriously ill patients. Our results suggest that it is feasible to use the Go Wish card game even in the chaotic inpatient setting to obtain an accurate portrayal of the patient's goals of care in a time-efficient manner. [Copyright U.S. Cancer Pain Relief Committee. Published by Elsevier Inc.] JF - Journal of Pain and Symptom Management AU - Lankarani-Fard, Azadeh AU - Knapp, Herschel AU - Lorenz, Karl A AU - Golden, Joya F AU - Taylor, Anne AU - Feld, Jamie E AU - Shugarman, Lisa R AU - Malloy, Demetria AU - Menkin, Elizabeth S AU - Asch, Steven M AD - VA Greater Los Angeles Healthcare System, Los Angeles, California, USA azadeh.lankarani-fard@med.va.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 637 EP - 643 PB - Elsevier, New York NY VL - 39 IS - 4 SN - 0885-3924, 0885-3924 KW - Feasibility KW - Hospitalization KW - Card games KW - End of life decisions KW - Spirituality KW - Palliative care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742720594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pain+and+Symptom+Management&rft.atitle=Feasibility+of+Discussing+End-of-Life+Care+Goals+with+Inpatients+Using+a+Structured%2C+Conversational+Approach%3A+The+Go+Wish+Card+Game&rft.au=Lankarani-Fard%2C+Azadeh%3BKnapp%2C+Herschel%3BLorenz%2C+Karl+A%3BGolden%2C+Joya+F%3BTaylor%2C+Anne%3BFeld%2C+Jamie+E%3BShugarman%2C+Lisa+R%3BMalloy%2C+Demetria%3BMenkin%2C+Elizabeth+S%3BAsch%2C+Steven+M&rft.aulast=Lankarani-Fard&rft.aufirst=Azadeh&rft.date=2010-04-01&rft.volume=39&rft.issue=4&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pain+and+Symptom+Management&rft.issn=08853924&rft_id=info:doi/10.1016%2Fj.jpainsymman.2009.08.011 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-06-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JSPME2 N1 - SubjectsTermNotLitGenreText - Card games; Hospitalization; Palliative care; Feasibility; End of life decisions; Spirituality DO - http://dx.doi.org/10.1016/j.jpainsymman.2009.08.011 ER - TY - JOUR T1 - Macrophage migration inhibitory factor anti-thrombin III complexes are decreased in bladder cancer patient serum: Complex formation as a mechanism of inactivation. AN - 733679106; 19762145 AB - Mounting evidence suggests that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) may serve as an important link between chronic inflammation and carcinogenesis as evidenced by the increase in serum MIF found in patients with various cancers. The present study identifies anti-thrombin III (ATIII) as an endogenous MIF binding protein, which reduces MIF biological activity. Serum MIF in bladder cancer patients (TCC stage II, n=50) was increased when compared to normal patients (n=50), while ATIII-MIF complexes were decreased in bladder cancer patient serum. These data suggest that increased circulating levels of bioactive MIF are present in bladder cancer patient serum. Published by Elsevier Ireland Ltd. JF - Cancer letters AU - Meyer-Siegler, Katherine L AU - Cox, Jacob AU - Leng, Lin AU - Bucala, Richard AU - Vera, Pedro L AD - Bay Pines VA Healthcare System, Research and Development, Bay Pines, FL 33744, USA. Katherine.Siegler@va.gov Y1 - 2010/04/01/ PY - 2010 DA - 2010 Apr 01 SP - 49 EP - 57 VL - 290 IS - 1 KW - Biomarkers, Tumor KW - 0 KW - Macrophage Migration-Inhibitory Factors KW - Multiprotein Complexes KW - Antithrombin III KW - 9000-94-6 KW - Index Medicus KW - Mass Spectrometry KW - Blotting, Western KW - Neoplasm Staging KW - Humans KW - Chromatography, Liquid KW - Enzyme-Linked Immunosorbent Assay KW - Carcinoma, Transitional Cell -- pathology KW - Urinary Bladder Neoplasms -- pathology KW - Carcinoma, Transitional Cell -- blood KW - Urinary Bladder Neoplasms -- blood KW - Biomarkers, Tumor -- blood KW - Macrophage Migration-Inhibitory Factors -- blood KW - Antithrombin III -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733679106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Macrophage+migration+inhibitory+factor+anti-thrombin+III+complexes+are+decreased+in+bladder+cancer+patient+serum%3A+Complex+formation+as+a+mechanism+of+inactivation.&rft.au=Meyer-Siegler%2C+Katherine+L%3BCox%2C+Jacob%3BLeng%2C+Lin%3BBucala%2C+Richard%3BVera%2C+Pedro+L&rft.aulast=Meyer-Siegler&rft.aufirst=Katherine&rft.date=2010-04-01&rft.volume=290&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=1872-7980&rft_id=info:doi/10.1016%2Fj.canlet.2009.08.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-07 N1 - Date created - 2010-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Med. 2000 Feb;6(2):164-70 [10655104] Mediators Inflamm. 2009;2009:535348 [19325914] Transplantation. 2001 Jun 27;71(12):1777-83 [11455258] Cancer. 2002 Mar 1;94(5):1449-56 [11920501] Blood. 2002 Jun 1;99(11):4015-20 [12010802] Anal Chem. 2002 Oct 15;74(20):5383-92 [12403597] Am J Pathol. 2002 Dec;161(6):2053-63 [12466122] Trends Cardiovasc Med. 2002 Nov;12(8):331-8 [12536119] Immunol Cell Biol. 2003 Apr;81(2):137-43 [12631237] Expert Opin Ther Targets. 2003 Apr;7(2):153-64 [12667094] J Endotoxin Res. 2003;9(2):119-23 [12803886] Anal Chem. 2003 Sep 1;75(17):4646-58 [14632076] J Biol Chem. 2004 Apr 2;279(14):13729-37 [14736878] BMC Cancer. 2004 Jul 12;4:34 [15248897] J Urol. 2004 Oct;172(4 Pt 1):1504-9 [15371880] Am J Clin Pathol. 1978 Feb;69(2):194-5 [629228] J Clin Pathol. 1979 Jan;32(1):21-5 [429575] Thromb Haemost. 1981 Aug 28;46(2):500-3 [7302888] J Urol. 1982 Jul;128(1):72-4 [7109075] Am J Med. 1989 Sep 11;87(3B):10S-14S [2552799] Thromb Haemost. 1996 Dec;76(6):897-901 [8972008] J Biol Chem. 1997 Aug 1;272(31):19393-400 [9235938] Int J Hematol. 1998 Jul;68(1):67-78 [9713170] BMC Cancer. 2005;5:73 [16000172] J Biol Chem. 2005 Nov 4;280(44):36541-4 [16115897] Eur J Immunol. 2005 Dec;35(12):3405-13 [16224818] World J Gastroenterol. 2006 Jan 7;12(1):60-5 [16440418] J Urol. 2006 Apr;175(4):1523-8 [16516040] J Immunol. 2006 Dec 15;177(12):8730-9 [17142775] Oncogene. 2007 May 14;26(22):3100-12 [17496909] Mol Endocrinol. 2007 Jun;21(6):1267-80 [17389748] Autoimmun Rev. 2007 Nov;7(1):8-11 [17967718] Electrophoresis. 2007 Dec;28(23):4302-10 [18041032] Intensive Care Med. 2008 Feb;34(2):361-7 [17940748] Inflamm Res. 2008 Feb;57(2):45-50 [18288453] J Cell Physiol. 2008 Jun;215(3):665-75 [18064633] Oncology. 2008;75(3-4):127-33 [18791328] J Clin Invest. 2008 Nov;118(11):3533-6 [18982159] J Cell Biochem. 2008 Dec 1;105(5):1279-88 [18821572] Mol Cell Biol. 2009 Apr;29(7):1922-32 [19188446] Blood. 2000 Feb 15;95(4):1117-23 [10666179] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.canlet.2009.08.025 ER - TY - CPAPER T1 - We Have the Scientific Evidence and Analytics. Now What? T2 - 2010 Evidence Based Medicine & Health Technology Assessment: Moving From Separate Appraisals to Synergistic Communications AN - 754225255; 5791874 JF - 2010 Evidence Based Medicine & Health Technology Assessment: Moving From Separate Appraisals to Synergistic Communications AU - Cary, Margaret Y1 - 2010/03/23/ PY - 2010 DA - 2010 Mar 23 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754225255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Evidence+Based+Medicine+%26+Health+Technology+Assessment%3A+Moving+From+Separate+Appraisals+to+Synergistic+Communications&rft.atitle=We+Have+the+Scientific+Evidence+and+Analytics.+Now+What%3F&rft.au=Cary%2C+Margaret&rft.aulast=Cary&rft.aufirst=Margaret&rft.date=2010-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Evidence+Based+Medicine+%26+Health+Technology+Assessment%3A+Moving+From+Separate+Appraisals+to+Synergistic+Communications&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHOME/Education/FindEducationalOffering.aspx? LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Posttraumatic Stress Disorder and Completed Suicide AN - 745643610; 13150789 AB - Most research regarding posttraumatic stress disorder (PTSD) and suicide has focused on suicidal ideation or attempts; no known study of the association between PTSD and completed suicide in a population-based sample has been reported. This study examined the association between PTSD and completed suicide in a population-based sample. Data were obtained from the nationwide Danish health and administrative registries, which include data on all 5.4 million residents of Denmark. All suicides between January 1, 1994, and December 31, 2006, were included, and controls were selected from a sample of all Danish residents. Using this nested case-control design, the authors examined 9,612 suicide cases and 199,306 controls matched to cases on gender, date of birth, and time. Thirty-eight suicide cases (0.40%) and 95 controls (0.05%) were diagnosed with PTSD. The odds ratio associating PTSD with suicide was 9.8 (95% confidence interval: 6.7, 15). The association between PTSD and completed suicide remained after controlling for psychiatric and demographic confounders (odds ratio = 5.3, 95% confidence interval: 3.4, 8.1). Additionally, persons with PTSD and depression had a greater rate of suicide than expected based on their independent effects. In conclusion, a registry-based diagnosis of PTSD based on International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, is a risk factor for completed suicide. JF - American Journal of Epidemiology AU - Gradus, Jaimie L AU - Qin, Ping AU - Lincoln, Alisa K AU - Miller, Matthew AU - Lawler, Elizabeth AU - Soerensen, Henrik Toft AU - Lash, Timothy L Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 721 EP - 727 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 171 IS - 6 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - case-control studies KW - stress disorders, post-traumatic KW - suicide KW - health problems KW - demography KW - posttraumatic stress disorder KW - Psychology KW - Gender KW - classification KW - Denmark KW - depression KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745643610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Posttraumatic+Stress+Disorder+and+Completed+Suicide&rft.au=Gradus%2C+Jaimie+L%3BQin%2C+Ping%3BLincoln%2C+Alisa+K%3BMiller%2C+Matthew%3BLawler%2C+Elizabeth%3BSoerensen%2C+Henrik+Toft%3BLash%2C+Timothy+L&rft.aulast=Gradus&rft.aufirst=Jaimie&rft.date=2010-03-15&rft.volume=171&rft.issue=6&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwp456 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - demography; health problems; posttraumatic stress disorder; Psychology; classification; Gender; depression; suicide; Denmark DO - http://dx.doi.org/10.1093/aje/kwp456 ER - TY - CPAPER T1 - Left Ventricular Mass Index Predicts Renal Outcomes in High Vascular Risk men: a 3-year Follow-up Study T2 - 59th Annual Scientific Session of the American College of Cardiology (ACC 2010) AN - 754191907; 5740758 JF - 59th Annual Scientific Session of the American College of Cardiology (ACC 2010) AU - Tsioufis, Konstantinos AU - Thomopoulos, C AU - Kokkinos, P AU - Faselis, C AU - Doumas, M AU - Papadopoulos, D AU - Kukar, N AU - Amdur, R AU - Papademetriou, V Y1 - 2010/03/14/ PY - 2010 DA - 2010 Mar 14 KW - Ventricle KW - Heart KW - Kidneys KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754191907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Scientific+Session+of+the+American+College+of+Cardiology+%28ACC+2010%29&rft.atitle=Left+Ventricular+Mass+Index+Predicts+Renal+Outcomes+in+High+Vascular+Risk+men%3A+a+3-year+Follow-up+Study&rft.au=Tsioufis%2C+Konstantinos%3BThomopoulos%2C+C%3BKokkinos%2C+P%3BFaselis%2C+C%3BDoumas%2C+M%3BPapadopoulos%2C+D%3BKukar%2C+N%3BAmdur%2C+R%3BPapademetriou%2C+V&rft.aulast=Tsioufis&rft.aufirst=Konstantinos&rft.date=2010-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Scientific+Session+of+the+American+College+of+Cardiology+%28ACC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={7A9907EF-0B49-442 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Visual Sequelae of Traumatic Brain Injury: A Systematic Review of the Literature T2 - Eighth World Congress on Brain Injury AN - 742825910; 5700063 JF - Eighth World Congress on Brain Injury AU - Adams, Elizabeth Y1 - 2010/03/10/ PY - 2010 DA - 2010 Mar 10 KW - Reviews KW - Brain KW - Traumatic brain injury KW - Complications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742825910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Eighth+World+Congress+on+Brain+Injury&rft.atitle=Visual+Sequelae+of+Traumatic+Brain+Injury%3A+A+Systematic+Review+of+the+Literature&rft.au=Adams%2C+Elizabeth&rft.aulast=Adams&rft.aufirst=Elizabeth&rft.date=2010-03-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eighth+World+Congress+on+Brain+Injury&rft.issn=&rft_id=info:doi/ L2 - https://ibia.conference-services.net/programme.asp?conferenceID=1677&l LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Aspiration Pneumonia Associated with the Use of Dantrolene Sodium in Low Level Responsive Patients with Traumatic Brain Injury T2 - Eighth World Congress on Brain Injury AN - 742814857; 5699975 JF - Eighth World Congress on Brain Injury AU - Corcoran, Michael AU - Makley, Michael Y1 - 2010/03/10/ PY - 2010 DA - 2010 Mar 10 KW - Sodium KW - Brain KW - Traumatic brain injury KW - Pneumonia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742814857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Eighth+World+Congress+on+Brain+Injury&rft.atitle=Aspiration+Pneumonia+Associated+with+the+Use+of+Dantrolene+Sodium+in+Low+Level+Responsive+Patients+with+Traumatic+Brain+Injury&rft.au=Corcoran%2C+Michael%3BMakley%2C+Michael&rft.aulast=Corcoran&rft.aufirst=Michael&rft.date=2010-03-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eighth+World+Congress+on+Brain+Injury&rft.issn=&rft_id=info:doi/ L2 - https://ibia.conference-services.net/programme.asp?conferenceID=1677&l LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Food, Diet and Brain Healthy Eating T2 - 25th International Conference of Alzheimer's Disease International AN - 742792579; 5681295 JF - 25th International Conference of Alzheimer's Disease International AU - Emerson Lombardo, N Y1 - 2010/03/10/ PY - 2010 DA - 2010 Mar 10 KW - Diets KW - Brain KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742792579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+International+Conference+of+Alzheimer%27s+Disease+International&rft.atitle=Food%2C+Diet+and+Brain+Healthy+Eating&rft.au=Emerson+Lombardo%2C+N&rft.aulast=Emerson+Lombardo&rft.aufirst=N&rft.date=2010-03-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+International+Conference+of+Alzheimer%27s+Disease+International&rft.issn=&rft_id=info:doi/ L2 - http://www.adi2010.org/Docs/Uploaded/ADI_Programme.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - A comprehensive analysis of the effect of DSP4 on the locus coeruleus noradrenergic system in the rat. AN - 733941527; 20045445 AB - Degeneration of the noradrenergic neurons in the locus coeruleus (LC) is a major component of Alzheimer's (AD) and Parkinson's disease (PD), but the consequence of noradrenergic neuronal loss has different effects on the surviving neurons in the two disorders. Therefore, understanding the consequence of noradrenergic neuronal loss is important in determining the role of this neurotransmitter in these neurodegenerative disorders. The goal of the study was to determine if the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) could be used as a model for either (or both) AD or PD. Rats were administered DSP4 and sacrificed 3 days 2 weeks and 3 months later. DSP4-treatment resulted in a rapid, though transient reduction in norepinephrine (NE) and NE transporter (NET) in many brain regions receiving variable innervation from the LC. Alpha(1)-adrenoreceptors binding site concentrations were unchanged in all brain regions at all three time points. However, an increase in alpha(2)-AR was observed in many different brain regions 2 weeks and 3 months after DSP4. These changes observed in forebrain regions occurred without a loss in LC noradrenergic neurons. Expression of synthesizing enzymes or NET did not change in amount of expression/neuron despite the reduction in NE tissue content and NET binding site concentrations at early time points, suggesting no compensatory response. In addition, DSP4 did not affect basal activity of LC at any time point in anesthetized animals, but 2 weeks after DSP4 there is a significant increase in irregular firing of noradrenergic neurons. These data indicate that DSP4 is not a selective LC noradrenergic neurotoxin, but does affect noradrenergic neuron terminals locally, as evident by the changes in transmitter and markers at terminal regions. However, since DSP4 did not result in a loss of noradrenergic neurons, it is not considered an adequate model for noradrenergic neuronal loss observed in AD and PD. Published by Elsevier Ltd. JF - Neuroscience AU - Szot, P AU - Miguelez, C AU - White, S S AU - Franklin, A AU - Sikkema, C AU - Wilkinson, C W AU - Ugedo, L AU - Raskind, M A AD - Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA. szot@u.washington.edu Y1 - 2010/03/10/ PY - 2010 DA - 2010 Mar 10 SP - 279 EP - 291 VL - 166 IS - 1 KW - Benzylamines KW - 0 KW - Neurotoxins KW - Norepinephrine Plasma Membrane Transport Proteins KW - Receptors, Adrenergic, alpha-1 KW - DSP 4 KW - PQ1P7JP5C1 KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Receptors, Adrenergic, alpha-1 -- metabolism KW - Action Potentials -- physiology KW - Animals KW - Norepinephrine Plasma Membrane Transport Proteins -- drug effects KW - Receptors, Adrenergic, alpha-1 -- drug effects KW - Norepinephrine Plasma Membrane Transport Proteins -- metabolism KW - Disease Models, Animal KW - Action Potentials -- drug effects KW - Neurotoxins -- toxicity KW - Binding Sites -- physiology KW - Rats KW - Rats, Sprague-Dawley KW - Time KW - Down-Regulation -- physiology KW - Binding Sites -- drug effects KW - Down-Regulation -- drug effects KW - Time Factors KW - Male KW - Locus Coeruleus -- pathology KW - Locus Coeruleus -- drug effects KW - Benzylamines -- toxicity KW - Nerve Degeneration -- metabolism KW - Norepinephrine -- metabolism KW - Nerve Degeneration -- pathology KW - Nerve Degeneration -- chemically induced KW - Locus Coeruleus -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733941527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=A+comprehensive+analysis+of+the+effect+of+DSP4+on+the+locus+coeruleus+noradrenergic+system+in+the+rat.&rft.au=Szot%2C+P%3BMiguelez%2C+C%3BWhite%2C+S+S%3BFranklin%2C+A%3BSikkema%2C+C%3BWilkinson%2C+C+W%3BUgedo%2C+L%3BRaskind%2C+M+A&rft.aulast=Szot&rft.aufirst=P&rft.date=2010-03-10&rft.volume=166&rft.issue=1&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=1873-7544&rft_id=info:doi/10.1016%2Fj.neuroscience.2009.12.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-04 N1 - Date created - 2010-02-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):135-40 [11113540] Behav Genet. 2000 May;30(3):171-82 [11105391] Brain Res. 2002 Aug 16;946(2):239-46 [12137927] Neuroscience. 2003;122(3):627-35 [14622906] Brain Res Brain Res Rev. 2004 Apr;45(1):38-78 [15063099] Brain Res. 1971 Apr 16;28(1):165-71 [4104275] Acta Physiol Scand Suppl. 1971;367:1-48 [4109331] Brain Res. 1974 Dec 27;82(2):263-8 [4140749] Brain Res. 1976 Aug 13;112(2):413-9 [8191] Annu Rev Neurosci. 1979;2:113-68 [231924] Br J Psychiatry. 1980 Jun;136:533-41 [6155966] Lancet. 1981 Apr 4;1(8223):783-4 [6110985] J Neurol Sci. 1981 Mar;49(3):419-28 [7217992] J Comp Neurol. 1983 Jul 10;217(4):418-31 [6886061] Proc Natl Acad Sci U S A. 1985 Jan;82(2):617-21 [2857492] Neurosci Lett. 1986 Mar 14;64(3):247-52 [3960404] Neuroscience. 1986 Jun;18(2):291-306 [3736860] Neuroscience. 1986 Jun;18(2):307-19 [3736861] Clin Chem. 1986 Nov;32(11):2030-3 [3096593] Neurology. 1987 Jan;37(1):42-6 [3796837] Adv Neurol. 1987;45:19-34 [2881444] Exp Neurol. 1988 Jul;101(1):75-86 [2899031] J Neurosci. 1989 May;9(5):1481-9 [2542474] J Histochem Cytochem. 1989 Sep;37(9):1435-42 [2768812] J Comp Neurol. 1989 Sep 15;287(3):373-92 [2570794] J Neurosci Res. 1990 Mar;25(3):395-404 [2325165] Prog Brain Res. 1991;88:257-68 [1726027] Prog Brain Res. 1991;88:625-30 [1726030] J Comp Neurol. 1992 Jul 15;321(3):421-41 [1506478] Ann Neurol. 1992 Nov;32(5):667-76 [1449247] Brain Res. 1993 Jun 18;614(1-2):21-8 [7688646] Neurochem Res. 1993 Dec;18(12):1321-7 [7505893] Eur J Pharmacol. 1993 Nov 2;249(1):37-41 [7506666] Neuropathol Appl Neurobiol. 1993 Dec;19(6):519-23 [8121544] Neurochem Int. 1994 Oct;25(4):395-400 [7820072] Neurosci Lett. 1995 Feb 15;186(1):45-8 [7540268] Neuropharmacology. 1996 Jan;35(1):63-70 [8684598] Neurodegeneration. 1996 Sep;5(3):241-9 [8910902] Eur J Pharmacol. 1996 Dec 12;317(1):83-90 [8982723] Brain Res Mol Brain Res. 1997 Feb;44(1):46-54 [9030697] Naunyn Schmiedebergs Arch Pharmacol. 1997 Feb;355(2):267-72 [9050022] Folia Neuropathol. 1997;35(2):80-6 [9377080] Psychopharmacology (Berl). 1998 Apr;136(3):299-303 [9566816] J Comp Neurol. 1979 Oct 15;187(4):703-24 [90684] J Neurosci Methods. 2006 Jan 15;150(1):111-5 [16098600] J Neurosci. 2006 Jan 11;26(2):467-78 [16407544] J Neurosci. 2006 Feb 1;26(5):1343-54 [16452658] J Neural Transm (Vienna). 2006 Sep;113(9):1119-29 [16362627] Brain Res. 2006 Sep 13;1109(1):45-53 [16854392] Eur J Neurosci. 2006 Nov;24(9):2622-30 [17100850] Neurobiol Dis. 2007 May;26(2):312-22 [17336077] Neuroscience. 2007 Apr 25;146(1):471-80 [17324522] J Chem Neuroanat. 2007 Nov;34(3-4):102-7 [17658239] Int J Neuropsychopharmacol. 2008 Aug;11(5):625-39 [18205979] J Neurosci. 2008 Dec 17;28(51):13805-14 [19091971] Neuropsychopharmacology. 2009 May;34(6):1467-81 [18923402] Neuropharmacology. 2009 May-Jun;56(6-7):1068-73 [19298831] Neurosci Lett. 2009 Sep 29;463(1):93-7 [19631722] Brain Res. 1977 May 20;127(1):25-53 [301051] Eur Neuropsychopharmacol. 1999 Dec;10(1):5-16 [10647090] J Neural Transm (Vienna). 1999;106(7-8):619-29 [10907722] J Neural Transm (Vienna). 2001;108(11):1239-47 [11768624] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuroscience.2009.12.027 ER - TY - JOUR T1 - Informal and formal care infrastructure and perceived need for caregiver training for frail US veterans referred to home and community-based services AN - 919971164; 201203244 AB - Objectives: To describe the informal care network of US veterans referred to home and community-based services (Homemaker Home Health services, H/HHA, or Home-Based Primary Care, HBPC) at the Durham Veterans Affairs Medical Center (VAMC), including: quantity and types of tasks provided and desired content for caregiver training programs. Methods: All primary care patients referred to H/HHA or HBPC during the preceding 3 months were sent questionnaires in May 2007. Additionally, caregivers were sent questionnaires if a patient gave permission. Descriptive statistics and chi-squared tests were performed. Results: On average, patients received 5.6 hours of VA care and 47 hours of informal care per week. 26% of patients (38% of patients with caregiver proxy respondents) and 59% of caregivers indicated the caregiver would be interested in participating in a training program by phone or on-site. Significant barriers to participation existed. The most common barriers were: transportation; no time due to caregiving or work demands; caregiver's own health limitations; and no need. Conclusions: Caregiver training needs to be tailored to overcome barriers to participate. Overcoming these barriers may be possible through in-home phone or internet training outside traditional business hours, and by tailoring training to accommodate limiting health problems among caregivers. [Reprinted by permission of Sage Publications, Ltd., copyright holder.] JF - Chronic Illness AU - Van Houtven, Courtney Harold AU - Oddone, Eugene Z AU - Weinberger, Morris AD - Center of Excellence in Health Services Research and Development in Primary Care, Veterans Administration, Durham VAMC, Durham, NC 27705, USA, Division of General Internal Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 57 EP - 66 PB - Sage Publications, London UK VL - 6 IS - 1 SN - 1742-3953, 1742-3953 KW - Caregiver training programs Frail elderly Informal care VA patients KW - Veterans KW - Health problems KW - Community based programmes KW - Informal care KW - Primary health care KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919971164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chronic+Illness&rft.atitle=Informal+and+formal+care+infrastructure+and+perceived+need+for+caregiver+training+for+frail+US+veterans+referred+to+home+and+community-based+services&rft.au=Van+Houtven%2C+Courtney+Harold%3BOddone%2C+Eugene+Z%3BWeinberger%2C+Morris&rft.aulast=Van+Houtven&rft.aufirst=Courtney&rft.date=2010-03-01&rft.volume=6&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Chronic+Illness&rft.issn=17423953&rft_id=info:doi/10.1177%2F1742395309352694 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Carers; Veterans; Informal care; Community based programmes; Primary health care; Health problems DO - http://dx.doi.org/10.1177/1742395309352694 ER - TY - JOUR T1 - Psychological health in older adult spousal caregivers of older adults AN - 919970652; 201202268 AB - Objectives: The need for informal caregiving has been rapidly increasing across several countries. Spouses comprise a sizeable segment of informal caregivers and typically represent an older cohort with special health concerns. The objective of this review was to examine psychological health outcomes in older adult spouses caring for older adults. Methods: Literature review/synthesis (1999--2009). Results: Compared to demographically matched married non-caregiving controls, older adult spousal caregivers experienced more cognitive functioning difficulties, strain, distress, stress, loneliness, depression, anxiety and poorer mental health. Caregivers of spouses with cognitive impairments, quite often wives, were especially affected by poor psychological health, as were caregivers who were new to the caregiving role and those who rated caregiving as stressful. Psychological health improved when the caregiving role ceased. Discussion: Several poor psychological outcomes were found in older adults caring for their spouses; the magnitude of which varied and were more pronounced under certain circumstances. To preserve caregiver health, maintain recipient health and care quality and avoid exceeding system of care capacity, efforts are needed to provide support to older adult spousal caregivers and recipients. Couples may need to be assessed as a unit, taking gender and cultural considerations into account, and additional resources may be required. [Reprinted by permission of Sage Publications, Ltd., copyright holder.] JF - Chronic Illness AU - Lavela, Sherri L AU - Ather, Nazneen AD - Center for Management of Complex Chronic Care, Department of Veterans Affairs, Edward Hines, Jr. VA Hospital, Hines, IL, USA sherri.lavela@va.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 67 EP - 80 PB - Sage Publications, London UK VL - 6 IS - 1 SN - 1742-3953, 1742-3953 KW - Ageing Caregiver Morbidity Psychological health Spouses KW - Psychological wellbeing KW - Elderly people KW - Health KW - Anxiety-Depression KW - Spouses KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919970652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chronic+Illness&rft.atitle=Psychological+health+in+older+adult+spousal+caregivers+of+older+adults&rft.au=Lavela%2C+Sherri+L%3BAther%2C+Nazneen&rft.aulast=Lavela&rft.aufirst=Sherri&rft.date=2010-03-01&rft.volume=6&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Chronic+Illness&rft.issn=17423953&rft_id=info:doi/10.1177%2F1742395309356943 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Carers; Elderly people; Psychological wellbeing; Spouses; Anxiety-Depression; Health DO - http://dx.doi.org/10.1177/1742395309356943 ER - TY - JOUR T1 - Racial and ethnic disparities in post-stroke depression detection AN - 754552469; 13310465 AB - Objectives Post-stroke depression (PSD) is common among stroke survivors and is associated with increased morbidity and mortality. Little is understood about racial/ethnic differences in PSD detection. This study assessed the racial/ethnic disparities in PSD detection in a national cohort of Department of Veterans Affairs (VA) acute stroke patients. Methods The study included VA patients who: received inpatient care for acute stroke within 2001; survived >60 days post-index hospitalization; had an index stay <365 days; and were confirmed VA healthcare enrollees. PSD was established if a patient had a depression diagnosis in VA or Medicare inpatient or outpatient files, or was dispensed an antidepressant with guideline recommended minimum daily dosage during the 12 months post stroke. A multivariate logistic regression model was fitted to estimate the effects of race/ethnicity on PSD detection, adjusting for sociodemographic and clinical factors. Results The study cohort (N = 5825) was comprised of 66% white, 22% black, 7% Hispanic, and 6% for all other racial/ethnic categories. Among these stroke patients, 39% had PSD. Black and all other racial/ethnic categories were significantly less likely to be diagnosed with PSD than non-Hispanic whites, even adjusting for potential risk factors. Conclusion White, non-Hispanic VA acute stroke patients were more likely to be diagnosed with PSD, even controlling for sociodemographic and clinical characteristics. Whether these findings suggest racial/ethnic differences in symptom endorsement by patients or in symptom recognition by providers is not clear. JF - International Journal of Geriatric Psychiatry AU - Jia, Huanguang AU - Chumbler, Neale R AU - Wang, Xinping AU - Chuang, Ho-Chih AU - Damush, Teresa M AU - Cameon, Randi AU - Williams, Linda S AD - Department of Veterans Affairs (VA) Rehabilitation Outcomes Research Center, North Florida/South Georgia Veterans Health System, Gainesville, FL, USA, Huanguang.Jia@va.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 298 EP - 304 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 25 IS - 3 SN - 0885-6230, 0885-6230 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Mortality KW - Antidepressants KW - Depression KW - Risk factors KW - Stroke KW - Geriatrics KW - Regression analysis KW - Morbidity KW - Ethnic groups KW - Races KW - Models KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754552469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Geriatric+Psychiatry&rft.atitle=Racial+and+ethnic+disparities+in+post-stroke+depression+detection&rft.au=Jia%2C+Huanguang%3BChumbler%2C+Neale+R%3BWang%2C+Xinping%3BChuang%2C+Ho-Chih%3BDamush%2C+Teresa+M%3BCameon%2C+Randi%3BWilliams%2C+Linda+S&rft.aulast=Jia&rft.aufirst=Huanguang&rft.date=2010-03-01&rft.volume=25&rft.issue=3&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Geriatric+Psychiatry&rft.issn=08856230&rft_id=info:doi/10.1002%2Fgps.2339 L2 - http://www3.interscience.wiley.com/journal/122523555/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Antidepressants; Mortality; Depression; Risk factors; Stroke; Regression analysis; Geriatrics; Races; Ethnic groups; Morbidity; Models DO - http://dx.doi.org/10.1002/gps.2339 ER - TY - JOUR T1 - Combat-related guilt mediates the relations between exposure to combat-related abusive violence and psychiatric diagnoses AN - 754550996; 13310888 AB - Background: This study examined the degree to which combat-related guilt mediated the relations between exposure to combat-related abusive violence and both Posttraumatic Stress Disorder (PTSD) and Major Depressive Disorder (MDD) in Vietnam Veterans. Methods: Secondary analyses were conducted on data collected from 1,323 male Vietnam Veterans as part of a larger, multisite study. Results: Results revealed that combat-related guilt partially mediated the association between exposure to combat-related abusive violence and PTSD, but completely mediated the association with MDD, with overall combat exposure held constant in the model. Follow-up analyses showed that, when comparing those participants who actually participated in combat-related abusive violence with those who only observed it, combat-related guilt completely mediated the association between participation in abusive violence and both PTSD and MDD. Moreover, when comparing those participants who observed combat-related abusive violence with those who had no exposure at all to it, combat-related guilt completely mediated the association between observation of combat-related abusive violence and MDD, but only partially mediated the association with PTSD. Conclusions: These findings suggest that guilt may be a mechanism through which abusive violence is related to PTSD and MDD among combat-deployed Veterans. These findings also suggest the importance of assessing abusive-violence related guilt among combat-deployed Veterans and implementing relevant interventions for such guilt whenever indicated. Depression and Anxiety, 2010. JF - Depression and Anxiety (Hoboken) AU - Marx, Brian P AU - Foley, Kristen M AU - Feinstein, Brian A AU - Wolf, Erika J AU - Kaloupek, Danny G AU - Keane, Terence M AD - Behavioral Sciences Division of the VA National Center for PTSD, Boston, Massachusetts, brian.marx@va.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 287 EP - 293 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 27 IS - 3 SN - 1091-4269, 1091-4269 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Depression KW - Data processing KW - posttraumatic stress disorder KW - Anxiety KW - Psychology KW - Violence KW - depression KW - Post-traumatic stress disorder KW - Vietnam KW - Models KW - secondary analysis KW - intervention KW - Aggression KW - Military personnel KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754550996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+Anxiety+%28Hoboken%29&rft.atitle=Combat-related+guilt+mediates+the+relations+between+exposure+to+combat-related+abusive+violence+and+psychiatric+diagnoses&rft.au=Marx%2C+Brian+P%3BFoley%2C+Kristen+M%3BFeinstein%2C+Brian+A%3BWolf%2C+Erika+J%3BKaloupek%2C+Danny+G%3BKeane%2C+Terence+M&rft.aulast=Marx&rft.aufirst=Brian&rft.date=2010-03-01&rft.volume=27&rft.issue=3&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Depression+and+Anxiety+%28Hoboken%29&rft.issn=10914269&rft_id=info:doi/10.1002%2Fda.20659 L2 - http://www3.interscience.wiley.com/journal/123249828/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Data processing; Depression; Anxiety; Aggression; Post-traumatic stress disorder; Military personnel; Models; posttraumatic stress disorder; secondary analysis; Psychology; intervention; depression; Violence; Vietnam DO - http://dx.doi.org/10.1002/da.20659 ER - TY - JOUR T1 - Relationship Between Alcohol Drinking and Aspartate Aminotransferase:Alanine Aminotransferase (AST:ALT) Ratio, Mean Corpuscular Volume (MCV), Gamma-Glutamyl Transpeptidase (GGT), and Apolipoprotein A1 and B in the U.S. Population AN - 745902188; 12580712 AB - Objective: The misuse of alcohol, even at levels just above two drinks per day, is a public health problem, but identifying patients with mis potentially unhealthy drinking is hindered by the lack of tests. Several blood tests, such as those testing for gamma-glutamyl transpeptidase (GGT) or mean corpuscular volume (MCV), are among the commonly used markers to identify very heavy drinking, but combinations of these markers have rarely been tested in lighter drinkers. We examined the relationship between alcohol drinking and the levels of these markers in a national population-based study composed primarily of lighter drinkers. Method: Data were analyzed from 8,708 adult participants in the third U.S. National Health and Nutrition Examination Survey after excluding subjects with iron overload; with hepatitis B and C; who were pregnant; and who were taking prescription drugs such as phenytoin (Dilantin), barbiturates, and hydroxyurea (Droxia and Hydrea). The relationship between the amount of alcohol drinking and GGT, aspartate aminotransferase:alanine aminotransferase ratio, MCV of erythrocytes, and apolipoprotein A1 and B were analyzed and adjusted for potential liver injury risk factors. Results: The prevalence of unhealthy alcohol drinking (defined as consumption of more than two standard drinks per day) was 6.7%. Heavier drinkers tended to be younger and reported an average of 4.2 drinks per day. When tested alone or in combination, the sensitivity and positive predictive values for these blood tests were too low to be clinically useful in identifying the subjects in the heavier drinking category. Conclusions: In this large, national, population-based study, the markers of heavy drinking studied here, either alone or in combination, did not appear to be useful in identifying unhealthy drinking. More work is needed to find the novel marker(s) associated with risky alcohol drinking. JF - Journal of Studies on Alcohol and Drugs AU - Liangpunsakul, S AU - Qi, R AU - Crabb, D W AU - Witzmann, F AD - Division of Gastroenterology and Hepatology, Department of Medicine, and Clarian Digestive Disease Center, Indiana University School of Medicine, and Roudebush Veterans Administration Medical Center, 550 North University Boulevard, UH 4100, Indianapolis, Indiana 46202-5124, USA, sliangpu@iupui.edu Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 249 EP - 252 VL - 71 IS - 2 SN - 1937-1888, 1937-1888 KW - Risk Abstracts KW - Alcohol KW - Sensitivity KW - Injuries KW - Erythrocytes KW - hepatitis B KW - Nutrition KW - Public health KW - Pregnancy KW - USA KW - Liver KW - Drugs KW - Iron KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745902188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Relationship+Between+Alcohol+Drinking+and+Aspartate+Aminotransferase%3AAlanine+Aminotransferase+%28AST%3AALT%29+Ratio%2C+Mean+Corpuscular+Volume+%28MCV%29%2C+Gamma-Glutamyl+Transpeptidase+%28GGT%29%2C+and+Apolipoprotein+A1+and+B+in+the+U.S.+Population&rft.au=Liangpunsakul%2C+S%3BQi%2C+R%3BCrabb%2C+D+W%3BWitzmann%2C+F&rft.aulast=Liangpunsakul&rft.aufirst=S&rft.date=2010-03-01&rft.volume=71&rft.issue=2&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Sensitivity; Alcohol; Injuries; Erythrocytes; Liver; hepatitis B; Nutrition; Iron; Drugs; Pregnancy; Public health; USA ER - TY - JOUR T1 - Inhaled albuterol/salbutamol and ipratropium bromide and their combination in the treatment of chronic obstructive pulmonary disease AN - 745609154; 12689861 AB - Importance of the field: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality throughout the world. Combination therapy with albuterol and ipratropium bromide was approved >15 years ago for the treatment of COPD. We review the mechanism of action, clinical efficacy, and safety of albuterol, ipratropium and combined albuterol-ipratropium therapy. Areas covered in this review: We conducted a PubMed literature search using the keywords COPD, albuterol, ipratropium bromide and Combivent(r) (Boehringer Ingelheim Corp., Ridgefield, CT, USA); pertinent references within the identified citations are included in the review. Data from the manufacturers are also evaluated. What the reader will gain: At the time of its approval, albuterol/ipratropium bromide was an innovative combination of existing medications for the treatment of COPD. The combined formulation provides better improvement in airflow than either component alone and, by reducing the number of separate inhalers, simplifies therapy and improves compliance compared with the individual components. Take home message: The recent development and approval of longer acting and more potent b agonists, anticholinergics and newer combination treatments have surpassed many of the advantages of combined albuterol-ipratropium for the treatment of patients with stable COPD. JF - Expert Opinion on Drug Metabolism and Toxicology AU - Gordon, Joshiah AU - Panos, Ralph J AD - 1Cincinnati Veterans Affairs Medical Center, Pulmonary, Critical Care, and Sleep Division, Cincinnati, OH 45220, USA +1 513 861 3100 ext. 4500; +1 513 487 6670, ralph.panos@va.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 381 EP - 392 PB - Informa Healthcare VL - 6 IS - 3 SN - 1742-5255, 1742-5255 KW - Toxicology Abstracts KW - Mortality KW - Data processing KW - Reviews KW - bromides KW - Acetylcholine receptors KW - Morbidity KW - Chronic obstructive pulmonary disease KW - salbutamol KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745609154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.atitle=Inhaled+albuterol%2Fsalbutamol+and+ipratropium+bromide+and+their+combination+in+the+treatment+of+chronic+obstructive+pulmonary+disease&rft.au=Gordon%2C+Joshiah%3BPanos%2C+Ralph+J&rft.aulast=Gordon&rft.aufirst=Joshiah&rft.date=2010-03-01&rft.volume=6&rft.issue=3&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.issn=17425255&rft_id=info:doi/10.1517%2F17425251003649549 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Reviews; Acetylcholine receptors; bromides; Morbidity; salbutamol; Chronic obstructive pulmonary disease DO - http://dx.doi.org/10.1517/17425251003649549 ER - TY - JOUR T1 - Neuropsychological performance following a history of multiple self-reported concussions: a meta-analysis. AN - 742787170; pmid-20003581 AB - Debate continues about the long-term neuropsychological impact of multiple mild traumatic brain injuries (MTBI). A meta-analysis of the relevant literature was conducted to determine the impact of having a history of more than one self-reported MTBI (versus just one MTBI) across seven cognitive domains, as well as symptom complaints. The analysis was based on 8 studies, all conducted with athletes, involving 614 cases of multiple MTBI and 926 control cases of a single MTBI. The overall effect of multiple MTBI on neuropsychological functioning was minimal and not significant (d = 0.06). However, follow-up analyses revealed that multiple self-reported MTBI was associated with poorer performance on measures of delayed memory and executive functioning. The implications and limitations of these findings are discussed. JF - Journal of the International Neuropsychological Society : JINS AU - Belanger, Heather G AU - Spiegel, Eric AU - Vanderploeg, Rodney D AD - Department of Mental Health and Behavioral Sciences, James A. Haley VA, Tampa, Florida 33612, USA. heather.belanger@va.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 262 EP - 267 VL - 16 IS - 2 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Severity of Illness Index KW - Humans KW - Recurrence KW - Cognition Disorders -- diagnosis KW - Brain Injuries -- physiopathology KW - Brain Concussion -- physiopathology KW - Cognition Disorders -- epidemiology KW - Brain Concussion -- epidemiology KW - Brain Injuries -- epidemiology KW - Truth Disclosure KW - Neuropsychological Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742787170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Neuropsychological+performance+following+a+history+of+multiple+self-reported+concussions%3A+a+meta-analysis.&rft.au=Belanger%2C+Heather+G%3BSpiegel%2C+Eric%3BVanderploeg%2C+Rodney+D&rft.aulast=Belanger&rft.aufirst=Heather&rft.date=2010-03-01&rft.volume=16&rft.issue=2&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-05-24 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Informed consent practices of Chinese nurse researchers AN - 742726590; 201011290 AB - Nursing research in China is at an early stage of development and little is known about the practices of Chinese nurse researchers. This interview study carried out at a university in central China explores the informed consent practices of Chinese nurse researchers and the cultural considerations of using a western technique. Nine semistructured interviews were conducted in English with assistance and simultaneous translation from a Chinese nurse with research experience. The interviews were analyzed by one western and two Chinese researchers and major themes were identified. All participants endorsed informed consent as ethically required. Differences were noted between some of the informed consent practices typically recommended in the USA and those identified in this study, such as: recruitment using local and government officials, recruiting directly from medical records without special permission, family consultation in consent and consent control, and not revealing randomization to intervention groups receiving different treatments. Adapted from the source document. JF - Nursing Ethics AU - Olsen, Douglas P AU - Wang, Honghong AU - Pang, Samantha AD - Veterans Health Administration, Washington, USA douglas.olsen@va.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 179 EP - 187 PB - Sage Publications, London UK VL - 17 IS - 2 SN - 0969-7330, 0969-7330 KW - China informed consent interview methodology research ethics KW - Informed consent KW - Consultation KW - Recruitment KW - Randomization KW - China KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742726590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Ethics&rft.atitle=Informed+consent+practices+of+Chinese+nurse+researchers&rft.au=Olsen%2C+Douglas+P%3BWang%2C+Honghong%3BPang%2C+Samantha&rft.aulast=Olsen&rft.aufirst=Douglas&rft.date=2010-03-01&rft.volume=17&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Nursing+Ethics&rft.issn=09697330&rft_id=info:doi/10.1177%2F0969733009355545 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Informed consent; Recruitment; China; Randomization; Consultation DO - http://dx.doi.org/10.1177/0969733009355545 ER - TY - JOUR T1 - Retired Status and Older Adults' 10-Year Drinking Trajectories AN - 742721092; 201012826 AB - Objective: Little research has examined the role of retirement in shaping late-life drinking careers, and it has generally been limited to cross-sectional designs or short-term follow-ups that emphasize group-level comparisons of retirees and nonretirees. The purpose of this study was to determine the following: (a) the effect of retired status on older adults' 10-year within-person drinking trajectories and (b) whether age, gender, income, health, and problem-drinker status account for or moderate this effect. Method: We first estimated older adults' (baseline M-62 years; n = 595) 10-year within-person drinking trajectories using three successively predictive multilevel regression models: unconditional growth, retired status alone, and retired status controlling for covariates. Next, we determined whether inclusion of Retired Status x Covariate interactions would improve prediction of the trajectories. Results: Participants' drinking frequency declined moderately over the 10-year interval, and retired status hastened the decline. However, this effect disappeared once covariates were added to the model: Baseline poorer health, lower income, and current problem-drinker status predicted steeper decline in drinking frequency, whereas former problem-drinker status predicted slower decline. Lower income and current drinking problems also predicted steeper declines in amount of alcohol consumed. There were no statistically significant or uniquely contributive interactions between retired status and age, gender, health, income, or drinking problems for predicting late-life drinking trajectories. Conclusions: Baseline health, income, and problem-drinking history are more important than retired status for predicting older adults' long-term within-person drinking trajectories. These factors-and recentcy of drinking problems-should be considered in future studies of retirement and late-life drinking patterns. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Brennan, Penny L AU - Schutte, Kathleen K AU - Moos, Rudolf H AD - Center for Health Care Evaluation (152-MPD), VA Palo Alto Health Care System, Menlo Park Division, 795 Willow Road, Menlo Park, CA 94025 penny.brennan@va.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 165 EP - 168 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 71 IS - 2 SN - 1937-1888, 1937-1888 KW - Alcohol consumption KW - Elderly people KW - Alcohol related problems KW - Gender KW - Health KW - Low income people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742721092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Retired+Status+and+Older+Adults%27+10-Year+Drinking+Trajectories&rft.au=Brennan%2C+Penny+L%3BSchutte%2C+Kathleen+K%3BMoos%2C+Rudolf+H&rft.aulast=Brennan&rft.aufirst=Penny&rft.date=2010-03-01&rft.volume=71&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-06-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alcohol consumption; Elderly people; Low income people; Health; Alcohol related problems; Gender ER - TY - JOUR T1 - Physical Activity in Middle-aged and Young-old Adults: The Roles of Self-efficacy, Barriers, Outcome Expectancies, Self-regulatory Behaviors and Social Support AN - 742719094; 201008935 AB - This study tests the associations of self-efficacy, outcome expectancies, perceived barriers, self-regulatory behaviors and social support with physical activity. Data from 116 married community-dwelling middle-aged and young-old couples (M = 58.86 years, SD = 7.16, range = 50 to 75) were collected via mail-in survey. The model indicated that self-efficacy was directly and indirectly related to physical activity through outcome expectancies, perceived barriers and self-regulatory behaviors. The results clarify the associations among the social cognitive constructs and physical activity, and suggest that interventions targeting multiple social cognitive constructs could increase the activity levels of middle-aged and young-old adults. [Copyright Sage Publications Ltd.] JF - Journal of Health Psychology AU - Ayotte, Brian J AU - Margrett, Jennifer A AU - Hicks-Patrick, Julie AD - VA Boston Healthcare System, USA brian.ayotte@va.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 173 EP - 185 PB - Sage Publications, London UK VL - 15 IS - 2 SN - 1359-1053, 1359-1053 KW - middle age physical activity social cognitive theory young-old adults KW - Selfefficacy KW - Elderly people KW - Social support KW - Physical activity KW - Selfregulation KW - Middle aged people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742719094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Psychology&rft.atitle=Physical+Activity+in+Middle-aged+and+Young-old+Adults%3A+The+Roles+of+Self-efficacy%2C+Barriers%2C+Outcome+Expectancies%2C+Self-regulatory+Behaviors+and+Social+Support&rft.au=Ayotte%2C+Brian+J%3BMargrett%2C+Jennifer+A%3BHicks-Patrick%2C+Julie&rft.aulast=Ayotte&rft.aufirst=Brian&rft.date=2010-03-01&rft.volume=15&rft.issue=2&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Psychology&rft.issn=13591053&rft_id=info:doi/10.1177%2F1359105309342283 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JHPSFC N1 - SubjectsTermNotLitGenreText - Physical activity; Selfregulation; Middle aged people; Selfefficacy; Social support; Elderly people DO - http://dx.doi.org/10.1177/1359105309342283 ER - TY - JOUR T1 - Coronary Heart Disease From a Life-Course Approach: Findings From the Health and Retirement Study, 1998-2004 AN - 741610285; 201006579 AB - Objective: Guided by a life-course approach to chronic disease, this study examined the ways in which childhood deprivation (low parental education and father's manual occupation) may be associated with coronary heart disease (CHD). Method: Multilevel modeling techniques and a nationally representative sample of Americans above age 50 from the Health and Retirement Study (HRS; N = 18,465) were used to examine childhood and CHD relationships over the course of 6 years (1998-2004). Results: Having a father with less than or equal to 8 years of education was associated with 11% higher odds of CHD, accounting for demographic characteristics, adult socioeconomic status (SES; education, income, and wealth), CHD risks (diabetes, hypertension, cigarette smoking, and obesity), and other factors (childhood health, exercise, stroke, and marital status). Discussion: Policies and programs aimed at improving the conditions of poor children and their families may effectively reduce the prevalence of CHD in later life. [Reprinted by permission of Sage Publications Ltd., copyright holder.] JF - Journal of Aging and Health AU - Bowen, Mary Elizabeth AD - James A. Haley Veterans Hospital, Tampa, FL Mary.Bowen3@va.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 219 EP - 241 PB - Sage Publications, Thousand Oaks CA VL - 22 IS - 2 SN - 0898-2643, 0898-2643 KW - life-course approach childhood deprivation social mobility healthy behaviors heart disease KW - Heart Diseases KW - Childhood KW - Socioeconomic Status KW - Health Problems KW - Retirement KW - Sociodemographic Factors KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/741610285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aging+and+Health&rft.atitle=Coronary+Heart+Disease+From+a+Life-Course+Approach%3A+Findings+From+the+Health+and+Retirement+Study%2C+1998-2004&rft.au=Bowen%2C+Mary+Elizabeth&rft.aulast=Bowen&rft.aufirst=Mary&rft.date=2010-03-01&rft.volume=22&rft.issue=2&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aging+and+Health&rft.issn=08982643&rft_id=info:doi/10.1177%2F0898264309355981 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-05-10 N1 - Number of references - 75 N1 - Last updated - 2016-09-28 N1 - CODEN - JAHEEG N1 - SubjectsTermNotLitGenreText - Sociodemographic Factors; Childhood; Health Problems; Heart Diseases; Socioeconomic Status; Retirement DO - http://dx.doi.org/10.1177/0898264309355981 ER - TY - JOUR T1 - Does comorbid substance use disorder impair recovery from major depression with SSRI treatment? An analysis of the STAR*D level one treatment outcomes AN - 57345389; 201006495 AB - Many patients with major depressive disorder (MDD) present with concurrent substance use disorders (SUDs), which has been thought to impair their response to antidepressants. Clinicians often delay antidepressant treatment until sustained sobriety has been established. Unfortunately, these comorbid subjects are typically excluded from depression treatment trials, leaving a gap in understanding the treatment outcomes. In the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, 2876 adult outpatients diagnosed with nonpsychotic MDD were prospectively treated with the selective serotonin-reuptake inhibitor (SSRI), citalopram, and returned for at least one post-baseline visit. Participants with SUD (29%) and without SUD (71%) were compared in regard to baseline clinical and sociodemographic features and treatment response. The group with MDD and SUD was further subdivided into those with alcohol only, drug only, and both alcohol and drug use. Despite clear sociodemographic and clinical differences, there were no significant differences between groups in the time to achieve response or rates of response to citalopram; however, those who endorsed both alcohol and drug use had significantly reduced rates of remission and significantly increased times to reach remission compared to the MDD group without SUD. In addition, subjects with MDD and SUD had higher risk of psychiatric serious adverse events (3.3% vs. 1.5%) and hospitalization (2.8% vs. 1.2%). The results indicate that first-line treatment with citalopram in depressed patients with alcohol or drug use respond as well as those without SUD. More intensive treatment is most likely needed for MDD patients with both drug and alcohol use disorders. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Davis, Lori L AU - Wisniewski, Stephen R AU - Howland, Robert H AU - Trivedi, Madhukar H AU - Husain, Mustafa M AU - Fava, Maurizio AU - McGrath, Patrick J AU - Balasubramani, G K AU - Warden, Diane AU - Rush, A John AD - VA Medical Center, 3701 Loop Road E., Tuscaloosa, AL 35404, United States lori.davis@va.gov Y1 - 2010/03/01/ PY - 2010 DA - 2010 Mar 01 SP - 161 EP - 170 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 107 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Major depression Substance use disorders Citalopram Alcohol use disorders Dual diagnosis Comorbidity KW - Alcohol consumption KW - Depressive personality disorders KW - Depression KW - Substance abuse disorders KW - Drug abuse KW - Citalopram KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57345389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Does+comorbid+substance+use+disorder+impair+recovery+from+major+depression+with+SSRI+treatment%3F+An+analysis+of+the+STAR*D+level+one+treatment+outcomes&rft.au=Davis%2C+Lori+L%3BWisniewski%2C+Stephen+R%3BHowland%2C+Robert+H%3BTrivedi%2C+Madhukar+H%3BHusain%2C+Mustafa+M%3BFava%2C+Maurizio%3BMcGrath%2C+Patrick+J%3BBalasubramani%2C+G+K%3BWarden%2C+Diane%3BRush%2C+A+John&rft.aulast=Davis&rft.aufirst=Lori&rft.date=2010-03-01&rft.volume=107&rft.issue=2-3&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2009.10.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Substance abuse disorders; Depressive personality disorders; Depression; Citalopram; Drug abuse; Alcohol consumption DO - http://dx.doi.org/10.1016/j.drugalcdep.2009.10.003 ER - TY - JOUR T1 - Transformational Leadership: Application of Magnet's New Empiric Outcomes AN - 57330700; 201007658 AB - The many benefits to hospitals throughout the world that achieved Magnet designation is well documented. This status of recognition demands the support of leadership during the Magnet journey. In 2008, the American Nurses Credentialing Center (ANCC) announced a new model for the Magnet Recognition Program that translates the original 14 Forces of Magnetism into Five Model Components. Specifically, this new model includes sources of evidence and empiric outcomes that by definition accentuates transformational nursing leadership. The day-to-day impact of this change places an even greater emphasis on demonstrated outcomes and innovation that may potentially transform nursing practice, quality and safety of care, and the population served. This article provides tangible examples and outcomes for reaching nursing excellence through leadership support and engagement. Keywords: Magnet; Transformation leadership; Empiric outcomes. [Copyright Elsevier B.V.] JF - Nursing Clinics of North America AU - Meredith, Erin K AU - Cohen, Elaine AU - Raia, Lucille V AD - James A. Haley Veterans' Hospital, 13000 Bruce B. Downs Boulevard, Tampa, FL 33612, USA erin.meredith@va.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 49 EP - 64 PB - Elsevier Ltd, The Netherlands VL - 45 IS - 1 SN - 0029-6465, 0029-6465 KW - Magnet Transformation leadership Empiric outcomes KW - Transformational leadership KW - Nursing KW - Professional practices KW - Leadership KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57330700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Clinics+of+North+America&rft.atitle=Transformational+Leadership%3A+Application+of+Magnet%27s+New+Empiric+Outcomes&rft.au=Meredith%2C+Erin+K%3BCohen%2C+Elaine%3BRaia%2C+Lucille+V&rft.aulast=Meredith&rft.aufirst=Erin&rft.date=2010-03-01&rft.volume=45&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Nursing+Clinics+of+North+America&rft.issn=00296465&rft_id=info:doi/10.1016%2Fj.cnur.2009.10.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Leadership; Nursing; Transformational leadership; Hospitals; Professional practices DO - http://dx.doi.org/10.1016/j.cnur.2009.10.007 ER - TY - JOUR T1 - Development of paratransgenic Artemia as a platform for control of infectious diseases in shrimp mariculture AN - 21284268; 12513975 AB - AbstractAim: To study the accumulation and retention of recombinant proteins in Artemia gut for optimizing paratransgenic disease control in shrimp aquaculture.Methods and Results: Transgenic Escherichia coli expressing fluorescent marker proteins and the transgenic cyanobacterium Synechococcus bacillarus expressing a functional murine single chain antibody, DB3, were fed to Artemia franciscana. Stable expression and retention of several marker molecules (e.g. GFP, DS Red and DB3) up to 10 h after of feeding with E. coli were evident within the gut of Artemia. Engineered strains of S. bacillarus expressing DB3 accumulated within the gut of Artemia with detectable antibody activity for 8-10 h of feeding via ELISA, coincident with the time period of the highest density of transgenic S. bacillarus in the Artemia gut.Conclusions: Artemia fed transgenic bacteria or algae accumulated recombinant proteins for up to 10 h that retained biological activity. Co-delivery of multiple recombinant proteins simultaneously in the gut of Artemia was also demonstrated.Significance and Impact of the Study: Expression of molecules that target infectious agents of mariculture in shrimp via commonly deployed feed organisms such as Artemia could potentially offer powerful new tools in the ongoing global effort to increase food supply. JF - Journal of Applied Microbiology AU - Subhadra, B AU - Hurwitz, I AU - Fieck, A AU - Rao, DVS AU - Subba Rao, G AU - Durvasula, R AD - 1 Department of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, USA 1, Ravi.Durvasula@med.va.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 831 EP - 840 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 108 IS - 3 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA Aquaculture Abstracts; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Artemia KW - disease control KW - paratransgenesis KW - shrimp culture KW - shrimp pathogens KW - Synechococcus bacillarus KW - Artemia franciscana KW - Food KW - Disease control KW - Infectious diseases KW - Escherichia coli KW - Fluorescent indicators KW - ELISA KW - Algae KW - Marine KW - Feeding KW - Enzyme-linked immunosorbent assay KW - Shrimp culture KW - Shellfish culture KW - Bacterial diseases KW - Husbandry diseases KW - Synechococcus KW - Antibodies KW - Cyanobacteria KW - Digestive tract KW - Fish diseases KW - Aquaculture development KW - Marine aquaculture KW - J 02410:Animal Diseases KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - K 03330:Biochemistry KW - Q1 08587:Diseases of Cultured Organisms KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21284268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Development+of+paratransgenic+Artemia+as+a+platform+for+control+of+infectious+diseases+in+shrimp+mariculture&rft.au=Subhadra%2C+B%3BHurwitz%2C+I%3BFieck%2C+A%3BRao%2C+DVS%3BSubba+Rao%2C+G%3BDurvasula%2C+R&rft.aulast=Subhadra&rft.aufirst=B&rft.date=2010-03-01&rft.volume=108&rft.issue=3&rft.spage=831&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fj.1365-2672.2009.04479.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Aquaculture development; Infectious diseases; Shellfish culture; Fish diseases; Shrimp culture; Husbandry diseases; Bacterial diseases; Disease control; ELISA; Marine aquaculture; Feeding; Enzyme-linked immunosorbent assay; Antibodies; Digestive tract; Food; Fluorescent indicators; Algae; Artemia franciscana; Cyanobacteria; Artemia; Escherichia coli; Synechococcus; Marine DO - http://dx.doi.org/10.1111/j.1365-2672.2009.04479.x ER - TY - JOUR T1 - Word-recognition performance in interrupted noise by young listeners with normal hearing and older listeners with hearing loss. AN - 85349973; pmid-20166311 AB - The most common complaint of adults with hearing loss is understanding speech in noise. One class of masker that may be particularly useful in the assessment of speech-in-noise abilities is interrupted noise. Interrupted noise usually is a continuous noise that has been multiplied by a square wave that produces alternating intervals of noise and silence. Wilson and Carhart found that spondaic word thresholds for listeners with normal hearing were 28 dB lower in an interrupted noise than in a continuous noise, whereas listeners with hearing loss experienced only an 11 dB difference.The purpose of this series of experiments was to determine if a speech-in-interrupted-noise paradigm differentiates better (1) between listeners with normal hearing and listeners with hearing loss and (2) among listeners with hearing loss than do traditional speech-in-continuous-noise tasks.Four descriptive/quasi-experimental studies were conducted.Sixty young adults with normal hearing and 144 older adults with pure-tone hearing losses participated.A 4.3 sec sample of speech-spectrum noise was constructed digitally to form the 0 interruptions per second (ips; continuous) noise and the 5, 10, and 20 ips noises with 50% duty cycles. The noise samples were mixed digitally with the Northwestern University Auditory Test No. 6 words at selected signal-to-noise ratios and recorded on CD. The materials were presented through an earphone, and the responses were recorded and analyzed at the word level. Similar techniques were used for the stimuli in the remaining experiments.In Experiment 1, using 0 ips as the reference condition, the listeners with normal hearing achieved 34.0, 30.2, and 28.4 dB escape from masking for 5, 10, and 20 ips, respectively. In contrast, the listeners with hearing loss only achieved 2.1 to 2.4 dB escape from masking. Experiment 2 studied the 0 and 5 ips conditions on 72 older listeners with hearing loss, who were on average 13 yr younger and more varied in their hearing loss than the listeners in Experiment 1. The mean escape from masking in Experiment 2 was 7dB, which is 20-25 dB less than the escape achieved by listeners with normal hearing. Experiment 3 examined the effects that duty cycle (0-100% in 10% steps) had on recognition performance in the 5 and 10 ips conditions. On the 12 young listeners with normal hearing, (1) the 50% correct point increased almost linearly between the 0 and 60% duty cycles (slope = 4.2 dB per 10% increase in duty cycle), (2) the slope of the function was steeper between 60 and 80% duty cycles, and (3) about the same masking was achieved for the 80-100% duty cycles. The data from the listeners with hearing loss were inconclusive. Experiment 4 varied the interburst ratios (0, -6, -12, -24, -48, and -infinity dB) of 5 ips noise and evaluated recognition performance by 24 young adults. The 50% points were described by a linear regression (R2 = 0.98) with a slope of 0.55 dB/dB.The current data indicate that interrupted noise does provide a better differentiation both between listeners with normal hearing and listeners with hearing loss and among listeners with hearing loss than is provided by continuous noise. JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AU - McArdle, Rachel AU - Betancourt, Mavie B AU - Herring, Kaileen AU - Lipton, Teresa AU - Chisolm, Theresa H AD - VA Medical Center, Mountain Home, TN 37684, USA. richard.wilson2@va.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 90 EP - 109 VL - 21 IS - 2 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation KW - Adult KW - Age Factors KW - Aged KW - Aged, 80 and over KW - Audiometry, Pure-Tone KW - Auditory Threshold KW - Female KW - Humans KW - Male KW - Middle Aged KW - *Noise KW - *Perceptual Masking KW - *Presbycusis: diagnosis KW - Reference Values KW - Sound Spectrography KW - *Speech Reception Threshold Test KW - Young Adult UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85349973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Word-recognition+performance+in+interrupted+noise+by+young+listeners+with+normal+hearing+and+older+listeners+with+hearing+loss.&rft.au=Wilson%2C+Richard+H%3BMcArdle%2C+Rachel%3BBetancourt%2C+Mavie+B%3BHerring%2C+Kaileen%3BLipton%2C+Teresa%3BChisolm%2C+Theresa+H&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2010-02-01&rft.volume=21&rft.issue=2&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Streptococcus anginosus (Streptococcus milleri Group) Pyomyositis in a 50-Year-Old Man with Acquired Immunodeficiency Syndrome: Case Report and Review of Literature AN - 746201133; 12592213 AB - We describe the first reported case of bacterial pyomyositisof the right thigh caused by Streptococcus anginosus(S. milleri group) in an HIV-infected patient. The clinicalpresentation was complicated by multiple ring-enhancinglesions detected on magnetic resonance imaging of thebrain. Evaluation for central nervous system toxoplasmosis,syphilis, and cryptococcal infection was negative. Aggressiveantibiotic therapy directed against S. anginosus and surgicaldebridement were limb salvaging. Clinicians should considerS. anginosus as a causative pathogen in HIV-associatedpyomyositis, particularly in complex presentations. Promptsurgical drainage may minimize complications due to S.anginosus, a pathogen associated with significant sequelaedue to its invasive nature. JF - Infection AU - Yassin, M AU - Yadavalli, G K AU - Alvarado, N AU - Bonomo, R A AD - Section of Infectious Diseases, Louis Stokes Cleveland Department ofVeterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH, 44106, USA, robert.bonomo@med.va.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 65 EP - 68 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 38 IS - 1 SN - 0300-8126, 0300-8126 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Case reports KW - Central nervous system KW - Drainage KW - Immunodeficiency KW - Infection KW - Limbs KW - Magnetic resonance imaging KW - Pathogens KW - Pyomyositis KW - Reviews KW - Streptococcus KW - Cryptococcus KW - Streptococcus anginosus KW - Human immunodeficiency virus KW - Streptococcus milleri KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746201133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection&rft.atitle=Streptococcus+anginosus+%28Streptococcus+milleri+Group%29+Pyomyositis+in+a+50-Year-Old+Man+with+Acquired+Immunodeficiency+Syndrome%3A+Case+Report+and+Review+of+Literature&rft.au=Yassin%2C+M%3BYadavalli%2C+G+K%3BAlvarado%2C+N%3BBonomo%2C+R+A&rft.aulast=Yassin&rft.aufirst=M&rft.date=2010-02-01&rft.volume=38&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Infection&rft.issn=03008126&rft_id=info:doi/10.1007%2Fs15010-009-6002-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Central nervous system; Limbs; Pyomyositis; Case reports; Reviews; Drainage; Magnetic resonance imaging; Immunodeficiency; Pathogens; Infection; Streptococcus; Human immunodeficiency virus; Streptococcus milleri; Cryptococcus; Streptococcus anginosus DO - http://dx.doi.org/10.1007/s15010-009-6002-9 ER - TY - JOUR T1 - Community-acquired pneumonia in the elderly AN - 746079407; 13042899 AB - Background: Community-acquired pneumonia (CAP) is a frequent cause of hospitalization and death among the elderly. Objective: This article reviews information on CAP among the elderly, including age-related changes, predisposing risk factors, causes, treatment strategies, and prevention. Methods: Searches of MEDLINE (January 1990-November 2009), International Pharmaceutical Abstracts (January 1990-November 2009), and Google Scholar were conducted using the terms community-acquired pneumonia, pneumonia, treatment guidelines, and elderly. Additional publications were found by searching the reference lists of the identified articles. Studies that reported diagnostic criteria as well as the treatment outcomes achieved in adult patients with CAP were selected for this review. Results: Three practice guidelines, 5 reviews, and 43 studies on CAP in the elderly were identified in the literature search. Based on those publications, risk factors that predispose the elderly to pneumonia include comorbid conditions, poor functional and nutritional status, consumption of alcohol, and smoking. The clinical presentation of pneumonia in the elderly (>=65 years of age) may be subtle, lacking the typical acute symptoms (fever, cough, dyspnea, and purulent sputum) observed in younger adults. Pneumonia should be suspected in all elderly patients who have fever, altered mental status, or a sudden decline in functional status, with or without lower respiratory tract symptoms such as cough, purulent sputum, and dyspnea. Treatment of CAP in the elderly should be guided by the latest recommendations of the Infectious Diseases Society of America and the American Thoracic Society (IDSA/ATS), along with consideration of local rates and patterns of antimicrobial resistance, as well as individual patient risk factors for acquiring less common or more resistant pathogens. Recommended empiric antimicrobial regimens generally consist of either a b-lactam plus a macrolide or a respiratory fluoroquinolone alone. Adherence to the IDSA/ATS guidelines has been found to improve in-hospital mortality (adherence vs nonadherence, 8%; 95% CI, 7%-10% vs 17%; 95% CI, 14%-20%; P< 0.01), length of hospital stay (8 days; interquartile range [IQR], 5-15 vs 10 days; IQR, 6-24 days, respectively; P < 0.01), and time to clinical stability in elderly patients with CAP (percentage of stable patients by day 7, 71%; 95% CI, 68%-74% vs 57%; 95% CI, 53%-61%, respectively; P < 0.01). All elderly patients should be vaccinated against pneumococcal disease and influenza based on recommendations from the Centers for Disease Control and Prevention. Lifestyle modifications and nutritional support are also important elements in the prevention of pneumonia in the elderly. Conclusion: Adherence to established guidelines, along with customization of antimicrobial therapy based on local rates and patterns of resistance and patient-specific risk factors, likely will improve the treatment outcome of elderly patients with CAP. JF - American Journal of Geriatric Pharmacotherapy AU - Fung, Horatio B AU - Monteagudo-Chu, Maricelle O AD - Pharmacy Service, James J. Peters Veterans Affairs Medical Center, Bronx, New York, horatio.fung@va.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 47 EP - 6247-62 PB - Excerpta Medica, Inc., PO Box 10670 Riverton, NJ 08076 USA VL - 8 IS - 1 SN - 1543-5946, 1543-5946 KW - Microbiology Abstracts B: Bacteriology KW - Age KW - Streptococcus pneumoniae KW - Geriatrics KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746079407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Geriatric+Pharmacotherapy&rft.atitle=Community-acquired+pneumonia+in+the+elderly&rft.au=Fung%2C+Horatio+B%3BMonteagudo-Chu%2C+Maricelle+O&rft.aulast=Fung&rft.aufirst=Horatio&rft.date=2010-02-01&rft.volume=8&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Geriatric+Pharmacotherapy&rft.issn=15435946&rft_id=info:doi/10.1016%2Fj.amjopharm.2010.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Geriatrics; Streptococcus pneumoniae DO - http://dx.doi.org/10.1016/j.amjopharm.2010.01.003 ER - TY - JOUR T1 - Computers in the treatment of chronic aphasia. AN - 742780643; pmid-20221953 AB - Computers and related technology can increase the amount of treatment received by adults with chronic aphasia. Computers used in treatment, however, are only valuable to the patient if the intervention is efficacious. Real and potential applications of computer technology are discussed in the context of three roles of computerized aphasia treatment for adults with chronic aphasia. Pertinent studies regarding Phases 1 and 2 are briefly described. The only Phase 3 study of efficacy of computerized aphasia treatment is more fully described and its implications discussed. JF - Seminars in speech and language AU - Katz, Richard C AD - Phoenix VA Health Care System, Phoenix, Arizona 85012-1839, USA. richard.katz@va.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 34 EP - 41 VL - 31 IS - 1 SN - 0734-0478, 0734-0478 KW - Index Medicus KW - National Library of Medicine KW - Language Tests KW - Software KW - Reading KW - Clinical Trials, Phase II as Topic KW - Clinical Trials, Phase I as Topic KW - Humans KW - Chronic Disease KW - Longitudinal Studies KW - Computers KW - Therapy, Computer-Assisted KW - Aphasia -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742780643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+speech+and+language&rft.atitle=Computers+in+the+treatment+of+chronic+aphasia.&rft.au=Katz%2C+Richard+C&rft.aulast=Katz&rft.aufirst=Richard&rft.date=2010-02-01&rft.volume=31&rft.issue=1&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Seminars+in+speech+and+language&rft.issn=07340478&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-06-07 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Risk Factors for Homelessness among Women Veterans AN - 742723308; 201014646 AB - Background. Women veterans are three to four times more likely than non-veteran women to become homeless. However, their risk factors for homelessness have not been defined. Methods. Case-control study of non-institutionalized homeless women veterans (n = 33) and age-matched housed women veterans (n = 165). Health, health care, and factors associated with homelessness were assessed using multiple logistic regression with a Monte Carlo algorithm to estimate exact standard errors of the model coefficients and p-values. Results. Characteristics associated with homelessness were sexual assault during military service, being unemployed, being disabled, having worse overall health, and screening positive for an anxiety disorder or post-traumatic stress disorder. Protective factors were being a college graduate or married. Conclusions. Efforts to assess housed women veterans' risk factors for homelessness should be integrated into clinical care programs within and outside the Veterans Administration. Programs that work to ameliorate risk factors may prevent these women's living situations from deteriorating over time. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Washington, Donna L AU - Yano, Elizabeth M AU - McGuire, James AU - Hines, Vivian AU - Lee, Martin AU - Gelberg, Lillian AD - VA Greater Los Angeles Health Care System, 11301 Wilshire Blvd., 111G, Los Angeles, CA 90073; (310) 478-3711 donna.washington@va.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 81 EP - 91 PB - John Hopkins University Press, Baltimore MD VL - 21 IS - 1 SN - 1049-2089, 1049-2089 KW - Homeless people, women, hospitals, veterans/utilization, ambulatory care/utilization, health services accessibility, health services needs and demands KW - Veterans KW - Risk factors KW - Women KW - Homelessness KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742723308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Risk+Factors+for+Homelessness+among+Women+Veterans&rft.au=Washington%2C+Donna+L%3BYano%2C+Elizabeth+M%3BMcGuire%2C+James%3BHines%2C+Vivian%3BLee%2C+Martin%3BGelberg%2C+Lillian&rft.aulast=Washington&rft.aufirst=Donna&rft.date=2010-02-01&rft.volume=21&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-06-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Veterans; Homelessness; Risk factors; Women ER - TY - JOUR T1 - Psychosocial Predictors of Employment Status Among Men Living With Spinal Cord Injury AN - 57357944; 201006253 AB - Objective: To explore the relationship between employment status and community access, perceived community discrimination, social support from significant others, depressive symptoms, and gender-related variables for 83 men living with spinal cord injury. Study Design: Correlational research. Setting: Internet-based investigation employing spinal cord injury listservs. Main Outcome Measure: Participant employment status. Results: A forced-entry hierarchical logistic regression indicated that means of injury, community access and perceived community discrimination, social support from significant others, depressive symptoms, and men's adherence to masculine norms for primacy of work, self-reliance, and emotional control significantly predicted employment status. Conclusions: Psychosocial variables such as community access, perceived discrimination, social support from significant others, depressive symptoms, and gender identity represent important and understudied predictors of employment status among men living with spinal cord injury. [Copyright The American Psychological Association.] JF - Rehabilitation Psychology AU - Burns, Shaun Michael AU - Boyd, Briana L AU - Hill, Justin AU - Hough, Sigmund AD - VA Boston Healthcare System, Harvard University Medical School shaun.burns@va.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 81 EP - 90 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 55 IS - 1 SN - 0090-5550, 0090-5550 KW - employment gender masculinity spinal cord injury Web-based research KW - Depression KW - Men KW - Spinal cord injuries KW - Discrimination KW - Psychosocial factors KW - Employment status KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57357944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rehabilitation+Psychology&rft.atitle=Psychosocial+Predictors+of+Employment+Status+Among+Men+Living+With+Spinal+Cord+Injury&rft.au=Burns%2C+Shaun+Michael%3BBoyd%2C+Briana+L%3BHill%2C+Justin%3BHough%2C+Sigmund&rft.aulast=Burns&rft.aufirst=Shaun&rft.date=2010-02-01&rft.volume=55&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Rehabilitation+Psychology&rft.issn=00905550&rft_id=info:doi/10.1037%2Fa0018583 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Psychosocial factors; Employment status; Spinal cord injuries; Men; Discrimination; Depression DO - http://dx.doi.org/10.1037/a0018583 ER - TY - JOUR T1 - Donepezil treatment and the subjective effects of intravenous cocaine in dependent individuals AN - 57345340; 201006871 AB - Acetylcholinesterase (AChE) inhibitors increase synaptic levels of acetylcholine (ACh) by inhibiting its breakdown. Donepezil is a reversible AChE inhibitor that is clinically available and relatively selective for inhibiting AChE but not other cholinesterases. Because AChE inhibitors have been shown to decrease the reinforcing effects of cocaine in animals, our hypothesis was that pretreatment with donepezil would attenuate the perceived value and other positive subjective effects of cocaine. We conducted a within-subject, double-blind, placebo-controlled, laboratory-based evaluation of the subjective effects produced by intravenous cocaine in human subjects receiving oral donepezil. Following three days of daily treatment with 5 mg of donepezil or oral placebo, participants received intravenous placebo or cocaine (0.18 and 0.36 mg/kg). After a three-day washout period, participants were crossed over to the opposite oral treatment, which was followed by identical intravenous infusions. Donepezil was well-tolerated with only two drug-related adverse events reported that were mild and self-limiting. Treatment with donepezil increased ratings of 'any' and 'good' drug effect produced by low-dose cocaine, without modifying the response to high-dose cocaine. When collapsed across intravenous dose, treatment with donepezil decreased dysphoric effects and somatic symptoms, but did not modify the value of cocaine injections as determined by the Multiple Choice Questionnaire (MCQ). In summary, pretreatment with donepezil potentiated some measures for nonspecific and positive effects of low-dose cocaine. Across all intravenous treatments, participants receiving donepezil reported fewer somatic-dysphoric effects. Neither of these actions support the value of donepezil as a treatment for cocaine dependence. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Grasing, Kenneth AU - Mathur, Deepan AU - Newton, Thomas F AU - Desouza, Cherilyn AD - Substance Abuse Research Laboratory, Kansas City Veterans Affairs Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA kenneth.grasing@med.va.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 69 EP - 75 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 107 IS - 1 SN - 0376-8716, 0376-8716 KW - Acetylcholine Cholinesterase inhibitors Cocaine Cocaine-related disorders Donepezil KW - Donepezil KW - Somatic symptoms KW - Multiple choice questionnaires KW - Breakdown KW - Cocaine KW - Drug dependency KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57345340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Donepezil+treatment+and+the+subjective+effects+of+intravenous+cocaine+in+dependent+individuals&rft.au=Grasing%2C+Kenneth%3BMathur%2C+Deepan%3BNewton%2C+Thomas+F%3BDesouza%2C+Cherilyn&rft.aulast=Grasing&rft.aufirst=Kenneth&rft.date=2010-02-01&rft.volume=107&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2009.09.010 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Donepezil; Cocaine; Breakdown; Somatic symptoms; Drug dependency; Multiple choice questionnaires DO - http://dx.doi.org/10.1016/j.drugalcdep.2009.09.010 ER - TY - JOUR T1 - Antibody response to hepatitis B vaccine in substance use disorder patients AN - 57344565; 201006924 AB - The objectives of this study were to assess the prevalence of prognostic factors previously known to be associated with poor antibody response to hepatitis B vaccination in a sample of veterans presenting for substance use disorders treatment at a Veterans Health Administration (VA) Medical Center, assess vaccination response, and identify markers for poor response in this population. Results indicated that most participants had multiple prognostic factors previously known to be associated with poor antibody response including male gender, age over 40, smoking, and obesity. The rate of seroconversion in this sample was 51.9%. This is substantially lower than seen in healthy adults. Alcohol dependence was the only significant independent negative predictor of seroconversion in this sample. Substance use disorders treatment providers who are considering adding hepatitis B vaccination services to their clinics should be aware that the antibody response to the hepatitis B vaccination is inconsistent and that patients with particular demographic characteristics may be at heightened risk of poor antibody response. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Hagedorn, Hildi J AU - Rettmann, Nancy A AU - Dieperink, Eric W AU - Durfee, Janet AU - Aqel, Bashar AD - Veterans Health Administration's Substance Use Disorders Quality Enhancement Research Initiative, Minneapolis VA Medical Center, Minneapolis, MN 55417, USA hildi.hagedorn@va.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 39 EP - 43 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 107 IS - 1 SN - 0376-8716, 0376-8716 KW - Hepatitis B vaccine Substance use disorders Substance abuse treatment programs Hepatitis services Veterans KW - Antibodies KW - Substance abuse disorders KW - Prognosis KW - Hepatitis B KW - Substance abuse KW - Immunization KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57344565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Antibody+response+to+hepatitis+B+vaccine+in+substance+use+disorder+patients&rft.au=Hagedorn%2C+Hildi+J%3BRettmann%2C+Nancy+A%3BDieperink%2C+Eric+W%3BDurfee%2C+Janet%3BAqel%2C+Bashar&rft.aulast=Hagedorn&rft.aufirst=Hildi&rft.date=2010-02-01&rft.volume=107&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2009.09.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Antibodies; Hepatitis B; Immunization; Substance abuse disorders; Substance abuse; Prognosis DO - http://dx.doi.org/10.1016/j.drugalcdep.2009.09.004 ER - TY - JOUR T1 - Actigraphic assessment of daily sleep-activity pattern abnormalities reflects self-assessed depression and anxiety in outpatients with advanced non-small cell lung cancer AN - 57341657; 201006581 AB - Objectives: We measured subjectively evaluated depression and anxiety, and objectively measured daily sleep-activity patterns in inpatients and outpatients with advanced non-small cell lung cancer (NSCLC) and determined whether cancer-associated depression and anxiety are accompanied by characteristic circadian rhythm abnormalities. Methods: Equal numbers of inpatients (n=42) and outpatients (n=42) with advanced NSCLC were studied. Baseline depression and anxiety, assessed by the Hospital Anxiety and Depression Scale (HADS), and actigraphy were recorded before chemotherapy initiation. The effects of the presence and severity of chronic obstructive pulmonary disease (COPD) on depression, anxiety, and actigraphy were assessed only among the 42 outpatients. Results: Anxiety occurred in 40% and depression in 25% of these lung cancer patients, equally among inpatients and outpatients. All patients suffer extremely disturbed daily sleep-activity cycles but each patient also maintains some degree of circadian organization. Outpatients maintain more robust daily activity patterns and longer, more consolidated nighttime sleep compared with inpatients. The more disrupted the daily sleep-activity rhythm, the worse the depression and/or anxiety scores for outpatients. These relationships are obscured among inpatients. COPD has no independent measurable effects on the daily organization of sleep-activity, depression, or anxiety. Conclusions: Lung cancer patients whose diurnal activity is disturbed by prolonged and frequent sedentary episodes and whose sleep is disturbed by frequent and prolonged waking are most anxious and depressed. These findings and relationships are masked by hospitalization. Since diurnal exercise improves both sleep and mood, it is reasonable to test whether enhancing daytime activity and nighttime sleep can diminish cancer-associated depression. [Copyright John Wiley and Sons, Ltd.] JF - Psycho-Oncology AU - Du-Quiton, Jovelyn AU - Wood, Patricia A AU - Burch, James B AU - Grutsch, James F AU - Gupta, Digant AU - Tyer, Kevin AU - Lis, Christopher G AU - Levin, Robert D AU - Quiton, Dinah Faith T AU - Reynolds, Justin L AU - Hrushesky, William J M AD - Medical Chronobiological Laboratory, WJB Dorn Veterans Affairs Medical Center, Columbia, SC, USA Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 180 EP - 189 PB - John Wiley, Chichester UK VL - 19 IS - 2 SN - 1057-9249, 1057-9249 KW - Outpatients KW - Hospitalization KW - Sleep KW - Chronic obstructive pulmonary disease KW - Lung cancer KW - Anxiety-Depression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57341657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=Actigraphic+assessment+of+daily+sleep-activity+pattern+abnormalities+reflects+self-assessed+depression+and+anxiety+in+outpatients+with+advanced+non-small+cell+lung+cancer&rft.au=Du-Quiton%2C+Jovelyn%3BWood%2C+Patricia+A%3BBurch%2C+James+B%3BGrutsch%2C+James+F%3BGupta%2C+Digant%3BTyer%2C+Kevin%3BLis%2C+Christopher+G%3BLevin%2C+Robert+D%3BQuiton%2C+Dinah+Faith+T%3BReynolds%2C+Justin+L%3BHrushesky%2C+William+J+M&rft.aulast=Du-Quiton&rft.aufirst=Jovelyn&rft.date=2010-02-01&rft.volume=19&rft.issue=2&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/10.1002%2Fpon.1539 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - POJCEE N1 - SubjectsTermNotLitGenreText - Anxiety-Depression; Outpatients; Hospitalization; Lung cancer; Chronic obstructive pulmonary disease; Sleep DO - http://dx.doi.org/10.1002/pon.1539 ER - TY - JOUR T1 - Non-fatal overdose in the 12 months following treatment for substance use disorders AN - 57341058; 201006213 AB - Background Overdose (OD) is a leading cause of mortality and morbidity for individuals with substance use disorders (SUDs), and there are limited prospective data on OD during the months following treatment for SUDs. Methods Variables associated with an OD in the 12 months after leaving an initial treatment episode were examined in an analysis of the Drug Abuse Treatment Outcomes Study (DATOS), a longitudinal naturalistic multisite study. Participants included 2966 patients with one or more SUDs. Non-fatal OD was ascertained by a positive response to 'In the past 12 months, have you overdosed on drugs?' Multivariate logistic regression analyses were used to identify variables associated with OD. Results By 12 months, 93 (3.1%) participants reported one or more ODs. Variables associated with OD were lifetime history of OD, injection drug use (IDU), male sex, greater pain, and history of sexual abuse. Conclusions OD-risk appears to be increased by IDU, lifetime OD, sexual abuse history, and pain. The latter finding is novel for a prospective report and requires further study. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Britton, Peter C AU - Wines, James D, Jr AU - Conner, Kenneth R AD - Center of Excellence, Department of Veteran Affairs Medical Center, 400 Fort Hill Avenue, Canandaigua, NY 14424, USA peter.britton@va.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 51 EP - 55 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 107 IS - 1 SN - 0376-8716, 0376-8716 KW - Epidemiology Overdose Treatment Risk factors Sexual abuse Intravenous drug abuse KW - Sexual abuse KW - Substance abuse disorders KW - Treatment KW - Substance abuse KW - Intravenous drug addicts KW - Morbidity-Mortality KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57341058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Non-fatal+overdose+in+the+12+months+following+treatment+for+substance+use+disorders&rft.au=Britton%2C+Peter+C%3BWines%2C+James+D%2C+Jr%3BConner%2C+Kenneth+R&rft.aulast=Britton&rft.aufirst=Peter&rft.date=2010-02-01&rft.volume=107&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2009.09.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Substance abuse; Morbidity-Mortality; Treatment; Substance abuse disorders; Intravenous drug addicts; Sexual abuse DO - http://dx.doi.org/10.1016/j.drugalcdep.2009.09.005 ER - TY - JOUR T1 - Assess Your Patient Safety Readiness AN - 21501868; 12492982 AB - What comes first, the chicken or the egg? biomedical/clinical engineering (BME/CE) departments and professionals that are interested in becoming more involved in patient safety initiatives may find this self-assessment tool to be a good reference to use to assess and enhance their programs. The tool is meant to give the reader a road map to ensure that he or she has all the necessary resources, policies, procedures, and training (e.g. in conducting medical device investigations, Failure Mode and Effect Analysis (FMEA) and Root Cause Analysis) before they offer to become more involved in the patient-safety movement at their facilities. JF - Biomedical Instrumentation & Technology AU - Patail, B AD - Ann Arbor, MI, USA, bryanne.patail@va.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 63 EP - 65 VL - 44 IS - 1 SN - 0899-8205, 0899-8205 KW - Biotechnology and Bioengineering Abstracts KW - Self-assessment KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21501868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+Instrumentation+%26+Technology&rft.atitle=Assess+Your+Patient+Safety+Readiness&rft.au=Patail%2C+B&rft.aulast=Patail&rft.aufirst=B&rft.date=2010-02-01&rft.volume=44&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Biomedical+Instrumentation+%26+Technology&rft.issn=08998205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Self-assessment ER - TY - JOUR T1 - K2 Serotype Klebsiella pneumoniae Causing a Liver Abscess Associated with Infective Endocarditis AN - 21480004; 12493574 AB - Klebsiella pneumoniae primary liver abscess (KPLA) is an emerging disease that is associated with distant septic complications. We report the first case of KPLA associated with infective endocarditis. The K. pneumoniae strain was a hypermucoid K2 serotype carrying the rmpA virulence-associated gene. JF - Journal of Clinical Microbiology AU - Rivero, Andres AU - Gomez, Eric AU - Alland, David AU - Huang, David B AU - Chiang, Tom AD - East Orange Veterans Affairs Medical Center, East Orange, New Jersey, Tom.Chiang@va.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 639 EP - 641 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 48 IS - 2 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Serotypes KW - Liver KW - Abscesses KW - Klebsiella pneumoniae KW - Endocarditis KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21480004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=K2+Serotype+Klebsiella+pneumoniae+Causing+a+Liver+Abscess+Associated+with+Infective+Endocarditis&rft.au=Rivero%2C+Andres%3BGomez%2C+Eric%3BAlland%2C+David%3BHuang%2C+David+B%3BChiang%2C+Tom&rft.aulast=Rivero&rft.aufirst=Andres&rft.date=2010-02-01&rft.volume=48&rft.issue=2&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.01779-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Serotypes; Liver; Abscesses; Endocarditis; Klebsiella pneumoniae DO - http://dx.doi.org/10.1128/JCM.01779-09 ER - TY - JOUR T1 - Inhibitor Resistance in the KPC-2 ?-Lactamase, a Preeminent Property of This Class A ?-Lactamase AN - 21304307; 11917294 AB - As resistance determinants, KPC ?-lactamases demonstrate a wide substrate spectrum that includes carbapenems, oxyimino-cephalosporins, and cephamycins. In addition, clinical strains harboring KPC-type ?-lactamases are often identified as resistant to standard ?-lactam-?-lactamase inhibitor combinations in susceptibility testing. The KPC-2 carbapenemase presents a significant clinical challenge, as the mechanistic bases for KPC-2-associated phenotypes remain elusive. Here, we demonstrate resistance by KPC-2 to ?-lactamase inhibitors by determining that clavulanic acid, sulbactam, and tazobactam are hydrolyzed by KPC-2 with partition ratios (kcat/kinact ratios, where kinact is the rate constant of enzyme inactivation) of 2,500, 1,000, and 500, respectively. Methylidene penems that contain an sp2-hybridized C3 carboxylate and a bicyclic R1 side chain (dihydropyrazolo[1,5-c][1,3]thiazole [penem 1] and dihydropyrazolo[5,1-c][1,4]thiazine [penem 2]) are potent inhibitors: Km of penem 1, 0.06 c 0.01 kM, and Km of penem 2, 0.006 c 0.001 kM. We also demonstrate that penems 1 and 2 are mechanism-based inactivators, having partition ratios (kcat/kinact ratios) of 250 and 50, respectively. To understand the mechanism of inhibition by these penems, we generated molecular representations of both inhibitors in the active site of KPC-2. These models (i) suggest that penem 1 and penem 2 interact differently with active site residues, with the carbonyl of penem 2 being positioned outside the oxyanion hole and in a less favorable position for hydrolysis than that of penem 1, and (ii) support the kinetic observations that penem 2 is the better inhibitor (kinact/Km = 6.5 c 0.6 kM-1 s-1). We conclude that KPC-2 is unique among class A ?-lactamases in being able to readily hydrolyze clavulanic acid, sulbactam, and tazobactam. In contrast, penem-type ?-lactamase inhibitors, by exhibiting unique active site chemistry, may serve as an important scaffold for future development and offer an attractive alternative to our current ?-lactamase inhibitors. JF - Antimicrobial Agents & Chemotherapy AU - Papp-Wallace, Krisztina M AU - Bethel, Christopher R AU - Distler, Anne M AU - Kasuboski, Courtney AU - Taracila, Magdalena AU - Bonomo, Robert A Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 890 EP - 897 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Enzymes KW - Carbapenems KW - carbapenemase KW - Tazobactam KW - Hydrolysis KW - scaffolds KW - Models KW - Sulbactam KW - Cephamycins KW - Kinetics KW - Clavulanic acid KW - Inactivators KW - carbonyls KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21304307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Inhibitor+Resistance+in+the+KPC-2+%3F-Lactamase%2C+a+Preeminent+Property+of+This+Class+A+%3F-Lactamase&rft.au=Papp-Wallace%2C+Krisztina+M%3BBethel%2C+Christopher+R%3BDistler%2C+Anne+M%3BKasuboski%2C+Courtney%3BTaracila%2C+Magdalena%3BBonomo%2C+Robert+A&rft.aulast=Papp-Wallace&rft.aufirst=Krisztina&rft.date=2010-02-01&rft.volume=54&rft.issue=2&rft.spage=890&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00693-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 59 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Carbapenems; Enzymes; Tazobactam; carbapenemase; Hydrolysis; scaffolds; Sulbactam; Models; Cephamycins; Clavulanic acid; Kinetics; Inactivators; carbonyls DO - http://dx.doi.org/10.1128/AAC.00693-09 ER - TY - JOUR T1 - Novel systems biology insights using antifibrotic approaches for diabetic kidney disease AN - 954600781; 14043657 AB - Although several interventions slow the progression of diabetic nephropathy, current therapies do not halt progression completely. Recent preclinical studies suggested that pirfenidone (PFD) prevents fibrosis in various diseases, but the mechanisms underlying its antifibrotic action are incompletely understood. To explore the therapeutic potential of PFD, we studied the PFD-treated db/db diabetic mouse kidney by liquid chromatography-tandem mass spectrometry proteomics. A total of 21 proteins unique to PFD-treated diabetic kidneys were identified. Analysis of gene ontology and protein-protein interactions of these proteins suggested that PFD may regulate RNA translation. Two key proteins involved in mRNA translation initiation and elongation were further evaluated and found to be regulated by PFD at the level of phosphorylation. In conclusion, insights from combining proteomics and bioinformatics improve the likelihood of rapid advancement of novel clinical therapies focused on reducing inflammation and fibrosis for diabetic complications. JF - Expert Review of Endocrinology & Metabolism AU - RamachandraRao, Satish P AU - Talwar, Priti AU - Ravasi, Timothy AU - Sharma, Kumar AD - Veterans Administration San Diego Healthcare System, La Jolla, CA, USA and Center for Renal Translational Medicine, Division of Nephrology and Hypertension, Department of Medicine, 407 Stein Clinical Research Building, Mail Box #0711, University of California, San Diego, La Jolla, CA 92093, USA. Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 127 EP - 135 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB UK VL - 5 IS - 1 SN - 1744-6651, 1744-6651 KW - Biotechnology and Bioengineering Abstracts KW - Translation initiation KW - Fibrosis KW - Kidney diseases KW - Mass spectroscopy KW - Inflammation KW - Diabetes mellitus KW - Elongation KW - Phosphorylation KW - Reviews KW - Nephropathy KW - Bioinformatics KW - proteomics KW - Protein interaction KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954600781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Review+of+Endocrinology+%26+Metabolism&rft.atitle=Novel+systems+biology+insights+using+antifibrotic+approaches+for+diabetic+kidney+disease&rft.au=RamachandraRao%2C+Satish+P%3BTalwar%2C+Priti%3BRavasi%2C+Timothy%3BSharma%2C+Kumar&rft.aulast=RamachandraRao&rft.aufirst=Satish&rft.date=2010-01-01&rft.volume=5&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Expert+Review+of+Endocrinology+%26+Metabolism&rft.issn=17446651&rft_id=info:doi/10.1586%2Feem.09.72 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Fibrosis; Translation initiation; Kidney diseases; Mass spectroscopy; Inflammation; Diabetes mellitus; Elongation; Phosphorylation; Reviews; Nephropathy; proteomics; Bioinformatics; Protein interaction DO - http://dx.doi.org/10.1586/eem.09.72 ER - TY - JOUR T1 - Applied Psychophysiology and Cognitive and Behavioral Therapy in the Treatment of Sex Offenders AN - 925740863; 201203928 AB - This article presents an application of applied psychophysiological and cognitive and behavioral strategies to the treatment of sex offenders. The participants were 21 sex offenders treated as outpatients at the Veterans Administration Medical Center in White River Junction, Vermont. A repeated-case-study format was used. Because hyperventilation destabilizes the autonomic nervous system (disrupting and/or preventing erection and other aspects of male sexual arousal) and dramatically changes brain function (degrading train of thought and shifting neuroendocrine function), clients were taught to hyperventilate in response to thoughts and images of the targets of their illegal behavior. Psychophysiological indices included skin conductance and penile plethysmograph. Participants were treated in six individual sessions, and most have been followed up for more than 2 years. Results show that with motivated clients, this procedure produces convincing, positive results. Adapted from the source document. JF - Biofeedback AU - Corson, John A AD - Dartmouth College and Dartmouth Medical School, Hanover, NH, and Veterans Administration Medical Center, White River Junction, VT John.A.Corson@Dartmouth.edu Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 148 EP - 154 PB - Allen Press, Lawrence KS VL - 38 IS - 4 SN - 1081-5937, 1081-5937 KW - applied psychophysiology, biofeedback, cognitive and behavioral therapy, sex offenders KW - Rivers KW - Sex offenders KW - Psychophysiological aspects KW - Hyperventilation KW - Brain KW - Military hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925740863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biofeedback&rft.atitle=Applied+Psychophysiology+and+Cognitive+and+Behavioral+Therapy+in+the+Treatment+of+Sex+Offenders&rft.au=Corson%2C+John+A&rft.aulast=Corson&rft.aufirst=John&rft.date=2010-01-01&rft.volume=38&rft.issue=4&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Biofeedback&rft.issn=10815937&rft_id=info:doi/10.5298%2F1081-5937-38.2.04 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Sex offenders; Psychophysiological aspects; Military hospitals; Brain; Hyperventilation; Rivers DO - http://dx.doi.org/10.5298/1081-5937-38.2.04 ER - TY - JOUR T1 - Real-Time Locating Systems (RTLS) to improve fall detection AN - 862594226; 201109328 AB - Objective To determine whether a Real Time Locating System (RTLS) can be used to accurately detect a fall and discuss the application of RTLS as a fall detection system in the home and health care environments. Methods Phase I used a mannequin to determine the feasibility of RTLS to detect a fall from three positional conditions of: standing, seated in a wheelchair, and laying on a bed. Phase II used a human subject to be an ecologically valid simulation of a fall from these conditions. Ten trials of each of these three conditions were conducted across subjects. The observed time of the fall (the 'gold standard') was compared with the RTLS tag position. A Receiver Operating Characteristic (ROC) curve was used to report the Area Under the Curve (AUC) with 95% confidence intervals (CI) and Cohen's kappa (x) was used to examine inter-rater reliability between the observed fall and the fall detected by the RTLS. Results RTLS accurately identified 89% (p [less than or equal to]0.001) of the mannequin falls and 80% (p [less than or equal to] 0.001) of the human falls. Across subjects there were low false positive rates (specificity); 17% for the mannequin and 16% for the human. Interrater reliability was very good (x=0.82; CI: 0.80-0.84) for mannequin falls and good (x =0.72; CI: 0.69-0.74) for human falls. Implications RTLS technology may be used to improve caregiver and staff response times, patient-care, and reduce health care costs associated with falls in later life. Adapted from the source document. JF - Gerontechnology AU - Elizabeth Bowen, Mary AU - Craighead, Jeffrey AU - Wingrave, Chadwick A AU - Kearns, William D AD - Veterans Hospital, HSR&D/RR&D Center of Excellence 8900 Grand Oak Circle, Tampa, FL 33637, USA mary.bowen3@va.gov Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 464 EP - 471 PB - International Society for Gerontechnology, Helsinki, Finland VL - 9 IS - 4 SN - 1569-1101, 1569-1101 KW - health care, elderly, radio-frequency identification devices (RFID) KW - Health costs KW - Interrater reliability KW - Falls KW - Detection KW - Confidence intervals KW - Wheelchairs KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862594226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gerontechnology&rft.atitle=Real-Time+Locating+Systems+%28RTLS%29+to+improve+fall+detection&rft.au=Elizabeth+Bowen%2C+Mary%3BCraighead%2C+Jeffrey%3BWingrave%2C+Chadwick+A%3BKearns%2C+William+D&rft.aulast=Elizabeth+Bowen&rft.aufirst=Mary&rft.date=2010-01-01&rft.volume=9&rft.issue=4&rft.spage=464&rft.isbn=&rft.btitle=&rft.title=Gerontechnology&rft.issn=15691101&rft_id=info:doi/10.4017%2Fgt.2010.09.04.005.00 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Falls; Health costs; Detection; Interrater reliability; Confidence intervals; Wheelchairs DO - http://dx.doi.org/10.4017/gt.2010.09.04.005.00 ER - TY - JOUR T1 - Gender Differences in Mental Health Diagnoses Among Iraq and Afghanistan Veterans Enrolled in Veterans Affairs Health Care AN - 856774995; 14103481 AB - OBJECTIVES: We examined gender differences in sociodemographic, military service, and mental health characteristics among Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) veterans. We evaluated associations between these sociodemographic and service characteristics and depression and posttraumatic stress disorder (PTSD) diagnoses. METHODS: In a retrospective, cross-sectional study, we used univariate descriptive statistics and log binominal regression analyses of Department of Veterans Affairs (VA) administrative data on 329 049 OEF and OIF veterans seeking VA health care from April 1, 2002, through March 31, 2008. RESULTS: Female veterans were younger and more likely to be Black and to receive depression diagnoses than were male veterans, who were more frequently diagnosed with PTSD and alcohol use disorders. Older age was associated with a higher prevalence of PTSD and depression diagnoses among women but not among men. CONCLUSIONS: Consideration of gender differences among OEF and OIF veterans seeking health care at the VA will facilitate more targeted prevention and treatment services for these newly returning veterans. JF - American Journal of Public Health AU - Maguen, Shira AU - Ren, Li AU - Bosch, Jeane O AU - Marmar, Charles R AU - Seal, Karen H AD - At the time of the study, the authors were with the San Francisco Veterans Administration (VA) Medical Center, California Y1 - 2010 PY - 2010 DA - 2010 SP - 2450 EP - 2456 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 100 IS - 12 SN - 0090-0036, 0090-0036 KW - Health & Safety Science Abstracts KW - Alcohol KW - posttraumatic stress disorder KW - Psychology KW - Afghanistan KW - depression KW - Iraq KW - Health care KW - Gender KW - prevention KW - Military KW - mental disorders KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856774995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Gender+Differences+in+Mental+Health+Diagnoses+Among+Iraq+and+Afghanistan+Veterans+Enrolled+in+Veterans+Affairs+Health+Care&rft.au=Maguen%2C+Shira%3BRen%2C+Li%3BBosch%2C+Jeane+O%3BMarmar%2C+Charles+R%3BSeal%2C+Karen+H&rft.aulast=Maguen&rft.aufirst=Shira&rft.date=2010-01-01&rft.volume=100&rft.issue=12&rft.spage=2450&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Alcohol; posttraumatic stress disorder; Health care; Psychology; Gender; prevention; Military; mental disorders; depression; Afghanistan; Iraq ER - TY - JOUR T1 - Investigations of roll-over shape: implications for design, alignment, and evaluation of ankle-foot prostheses and orthoses AN - 853207877; 201105458 AB - Purpose. The purpose of this article is to provide an overview of our previous work on roll-over shapes, which are the effective rocker shapes that the lower limb systems conform to during walking. Method. This article is a summary of several recently published articles from the Northwestern University Prosthetics Research Laboratory and Rehabilitation Engineering Research Program on the topic of roll-over shapes. The roll-over shape is a measurement of centre of pressure of the ground reaction force in body-based coordinates. This measurement is interpreted as the effective rocker shape created by lower limb systems during walking. Results. Our studies have shown that roll-over shapes in able-bodied subjects do not change appreciably for conditions of level ground walking, including walking at different speeds, while carrying different amounts of weight, while wearing shoes of different heel heights, or when wearing shoes with different rocker radii. In fact, results suggest that able-bodied humans will actively change their ankle movements to maintain the same roll-over shapes. Conclusions. The consistency of the roll-over shapes to level surface walking conditions has provided insight for design, alignment and evaluation of lower limb prostheses and orthoses. Changes to ankle-foot and knee-ankle-foot roll-over shapes for ramp walking conditions have suggested biomimetic (i.e. mimicking biology) strategies for adaptable ankle-foot prostheses and orthoses. Adapted from the source document. JF - Disability and Rehabilitation AU - Hansen, Andrew H AU - Childress, Dudley S AD - Minneapolis VA Medical Center, One Veterans Drive (151), Minneapolis, MN 55417, USA andrew.hansen2@va.gov Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 2201 EP - 2209 PB - Informa Healthcare, New York NY VL - 32 IS - 26 SN - 0963-8288, 0963-8288 KW - Artificial limbs prostheses orthoses gait KW - Measurement KW - Engineering KW - Rehabilitation KW - Lower limbs KW - Walking KW - Biology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853207877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Disability+and+Rehabilitation&rft.atitle=Investigations+of+roll-over+shape%3A+implications+for+design%2C+alignment%2C+and+evaluation+of+ankle-foot+prostheses+and+orthoses&rft.au=Hansen%2C+Andrew+H%3BChildress%2C+Dudley+S&rft.aulast=Hansen&rft.aufirst=Andrew&rft.date=2010-01-01&rft.volume=32&rft.issue=26&rft.spage=2201&rft.isbn=&rft.btitle=&rft.title=Disability+and+Rehabilitation&rft.issn=09638288&rft_id=info:doi/10.3109%2F09638288.2010.502586 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - CODEN - DREHET N1 - SubjectsTermNotLitGenreText - Walking; Lower limbs; Measurement; Engineering; Biology; Rehabilitation DO - http://dx.doi.org/10.3109/09638288.2010.502586 ER - TY - JOUR T1 - Prevalence and degree of hearing loss among males in Beaver Dam cohort: Comparison of veterans and nonveterans AN - 807287738; 13867263 AB - The Epidemiology of Hearing Loss Study (EHLS) conducted in Beaver Dam, Wisconsin, was a population-based study that focused on the prevalence of hearing loss among 3,753 participants between 1993 and 1995. This article reports the results of several auditory measures from 999 veteran and 590 nonveteran males 48 to 92 years of age included in the EHLS. The auditory measures included pure tone thresholds, tympanometry and acoustic reflexes, word recognition in quiet and in competing message, and the Hearing Handicap Inventory for the Elderly-Screening (HHIE-S) version. Hearing loss in the auditory domains of pure tone thresholds, word recognition in quiet, and word recognition in competing message increased with age but were not significantly different for the veterans and nonveterans. No significant differences were found between participant groups on the HHIE-S; however, regarding hearing aid usage, mixed differences were found. JF - Journal of Rehabilitation Research and Development AU - Wilson, R H AU - Noe, C M AU - Cruickshanks, K J AU - Wiley, T L AU - Nondahl, D M AD - VA Medical Center, Audiology/Research Audiology (126), Mountain Home, TN 37684-4000, USA, richard.wilson2@va.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 505 EP - 520 VL - 47 IS - 6 SN - 0748-7711, 0748-7711 KW - Health & Safety Science Abstracts KW - Age KW - Acoustics KW - males KW - Hearing loss KW - USA, Wisconsin KW - Research programs KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807287738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Prevalence+and+degree+of+hearing+loss+among+males+in+Beaver+Dam+cohort%3A+Comparison+of+veterans+and+nonveterans&rft.au=Wilson%2C+R+H%3BNoe%2C+C+M%3BCruickshanks%2C+K+J%3BWiley%2C+T+L%3BNondahl%2C+D+M&rft.aulast=Wilson&rft.aufirst=R&rft.date=2010-01-01&rft.volume=47&rft.issue=6&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2009.10.0169 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Age; Acoustics; males; Hearing loss; Research programs; USA, Wisconsin DO - http://dx.doi.org/10.1682/JRRD.2009.10.0169 ER - TY - JOUR T1 - Servicemembers and veterans with major traumatic limb loss from Vietnam war and OIF/OEF conflicts: Survey methods, participants, and summary findings AN - 754535689; 13243079 AB - Care of veterans and servicemembers with major traumatic limb loss from combat theaters is one of the highest priorities of the Department of Veteran Affairs. We achieved a 62% response rate in our Survey for Prosthetic Use from 298 Vietnam war veterans and 283 servicemembers/veterans from Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) who sustained major traumatic limb loss. Participants reported their combat injuries; health status; quality of life; and prosthetic device use, function, rejection, and satisfaction. Despite the serious injuries experienced, health status was rated excellent, very good, or good by 70.7% of Vietnam war and 85.5% of OIF/OEF survey participants. However, many health issues persist for Vietnam war and OIF/OEF survey participants (respectively): phantom limb pain (72.2%/76.0%), chronic back pain (36.2%/42.1%), residual-limb pain (48.3%/62.9%), prosthesis-related skin problems (51.0%/58.0%), hearing loss (47.0%/47.0%), traumatic brain injury (3.4%/33.9%), depression (24.5%/24.0%), and posttraumatic stress disorder (37.6%/58.7%). Prosthetic devices are currently used by 78.2% of Vietnam war and 90.5% of OIF/OEF survey participants to improve function and mobility. On average, the annual rate for prosthetic device receipt is 10.7-fold higher for OIF/OEF than for Vietnam war survey participants. Findings from this cross-conflict survey identify many strengths in prosthetic rehabilitation for those with limb loss and several areas for future attention. JF - Journal of Rehabilitation Research and Development AU - Reiber, GE AU - McFarland, LV AU - Hubbard, S AU - Maynard, C AU - Blough, D K AU - Gambel, J M AU - Smith, D G AD - VA Puget Sound Health Care System, Health Services Research and Development, 1100 Olive Way, Suite 1400, Seattle, WA 98101, USA, Gayle.Reiber@va.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 275 EP - 298 VL - 47 IS - 4 SN - 0748-7711, 0748-7711 KW - Health & Safety Science Abstracts KW - conflicts KW - Skin KW - Mobility KW - Injuries KW - Psychology KW - Brain KW - pain KW - Hearing loss KW - depression KW - back pain KW - war KW - Vietnam KW - quality of life KW - Research programs KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754535689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Servicemembers+and+veterans+with+major+traumatic+limb+loss+from+Vietnam+war+and+OIF%2FOEF+conflicts%3A+Survey+methods%2C+participants%2C+and+summary+findings&rft.au=Reiber%2C+GE%3BMcFarland%2C+LV%3BHubbard%2C+S%3BMaynard%2C+C%3BBlough%2C+D+K%3BGambel%2C+J+M%3BSmith%2C+D+G&rft.aulast=Reiber&rft.aufirst=GE&rft.date=2010-01-01&rft.volume=47&rft.issue=4&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2010.01.0009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - conflicts; Skin; Injuries; Mobility; Psychology; Brain; pain; Hearing loss; back pain; depression; war; quality of life; Research programs; Vietnam DO - http://dx.doi.org/10.1682/JRRD.2010.01.0009 ER - TY - JOUR T1 - The influence of antiviral therapy on psychiatric symptoms among patients with hepatitis C and schizophrenia AN - 754534071; 13230577 AB - Background: Antiviral therapy for chronic infection with HCV is associated with significant neuropsychiatric side effects. Research indicates that patients with mental illness are less likely to receive antiviral therapy, despite limited data regarding the influence of antiviral therapy on psychiatric symptoms in patients with specific psychiatric disorders. The aim of this study was to determine whether antiviral therapy is associated with higher rates of psychiatric symptoms in patients with schizophrenia (SCHZ). Methods: A regional Veterans Healthcare Administration database was used to identify veterans meeting criteria for this retrospective chart review. Patients confirmed to have SCHZ and to have received antiviral therapy for HCV between 1998 and 2006 (n=30) were compared with a control group of demographically matched (age, race and gender) patients with SCHZ who did not receive antiviral therapy (n=30). Clinicians blinded to antiviral therapy status used chart notes to evaluate whether patients exhibited prominent symptoms of SCHZ, depression or mania during a 6 month pre-treatment period, the treatment period and a 6 month post-treatment period (or during equivalent periods for the control group). Results: Groups did not significantly differ in rates of symptoms of SCHZ, depression or mania during any study period. During the treatment period, groups did not significantly differ in rates of emergency room visits or inpatient hospitalizations. Conclusions: Our retrospective chart review suggests that patients with SCHZ experience similar rates of psychiatric symptoms on and off antiviral therapy. Despite limitations and constraints of the methods, our data suggest that SCHZ is not a contraindication to antiviral therapy for HCV. JF - Antiviral Therapy AU - Huckans, M AU - Mitchell, A AU - Pavawalla, S AU - Morasco, B J AU - Ruimy, S AU - Loftis, J M AU - Rifai, MA AU - Hauser, P Y1 - 2010 PY - 2010 DA - 2010 SP - 111 EP - 119 VL - 15 IS - 1 SN - 1359-6535, 1359-6535 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; CSA Neurosciences Abstracts KW - Schizophrenia KW - Databases KW - Mental disorders KW - Data processing KW - Depression KW - Hepatitis C virus KW - Affective disorders KW - Chronic infection KW - Hepatitis C KW - Side effects KW - Races KW - A 01340:Antibiotics & Antimicrobials KW - V 22410:Animal Diseases KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754534071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Therapy&rft.atitle=The+influence+of+antiviral+therapy+on+psychiatric+symptoms+among+patients+with+hepatitis+C+and+schizophrenia&rft.au=Huckans%2C+M%3BMitchell%2C+A%3BPavawalla%2C+S%3BMorasco%2C+B+J%3BRuimy%2C+S%3BLoftis%2C+J+M%3BRifai%2C+MA%3BHauser%2C+P&rft.aulast=Huckans&rft.aufirst=M&rft.date=2010-01-01&rft.volume=15&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Antiviral+Therapy&rft.issn=13596535&rft_id=info:doi/10.3851%2FIMP1493 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Databases; Mental disorders; Depression; Data processing; Affective disorders; Chronic infection; Hepatitis C; Races; Side effects; Hepatitis C virus DO - http://dx.doi.org/10.3851/IMP1493 ER - TY - JOUR T1 - Effectiveness of Alcohol-Based Hand Rubs for Removal of Clostridium difficile Spores from Hands AN - 746155486; 12845286 AB - Background. Alcohol-based hand rubs (ABHRs) are an effective means of decreasing the transmission of bacterial pathogens. Alcohol is not effective against Clostridium difficile spores. We examined the retention of C. difficile spores on the hands of volunteers after ABHR use and the subsequent transfer of these spores through physical contact. Methods. Nontoxigenic C. difficile spores were spread on the bare palms of 10 volunteers. Use of 3 ABHRs and chlorhexidine soap-and-water washing were compared with plain water rubbing alone for removal of C. difficile spores. Palmar cultures were performed before and after hand decontamination by means of a plate stamping method. Transferability of C. difficile after application of ABHR was tested by having each volunteer shake hands with an uninoculated volunteer. Results. Plain water rubbing reduced palmar culture counts by a mean (c standard deviation [SD]) of 1.57 c 0.11 log sub(10) colony-forming units (CFU) per cm super(2), and this value was set as the zero point for the other products. Compared with water washing, chlorhexidine soap washing reduced spore counts by a mean (cSD) of 0.89 c 0.34 log sub(10) CFU per cm super(2); among the ABHRs, Isagel accounted for a reduction of 0.11 c 0.20 log sub(10) CFU per cm super(2), Endure for a reduction of 0.37 c 0.42 log sub(10) CFU per cm super(2), and Purell for a reduction of 0.14 c 0.33 log sub(10) CFU per cm super(2). There were no statistically significant differences between the reductions achieved by the ABHRs; only Endure had a reduction statistically different from that for water control rubbing. After ABHR use, handshaking transferred a mean of 30% of the residual C. difficile spores to the hands of recipients. Conclusions. Hand washing with soap and water is significantly more effective at removing C. difficile spores from the hands of volunteers than are ABHRs. Residual spores are readily transferred by a handshake after use of ABHR. JF - Infection Control and Hospital Epidemiology AU - Jabbar, Umair AU - Leischner, Julie AU - Kasper, Douglas AU - Gerber, Robert AU - Sambol, Susan P AU - Parada, Jorge P AU - Johnson, Stuart AU - Gerding, Dale N AD - From Loyola University Chicago, Stritch School of Medicine, Maywood, and Edward Hines Jr Veterans Affairs Hospital, Hines, Illinois., dale.gerding2@va.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 565 EP - 570 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 31 IS - 6 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - Alcohol KW - Chlorhexidine KW - Statistical analysis KW - Hand KW - Decontamination KW - Pathogens KW - Standard deviation KW - Colony-forming cells KW - alcohols KW - Clostridium difficile KW - plains KW - Soaps KW - Spores KW - Hospitals KW - H 12000:Epidemiology and Public Health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746155486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Effectiveness+of+Alcohol-Based+Hand+Rubs+for+Removal+of+Clostridium+difficile+Spores+from+Hands&rft.au=Jabbar%2C+Umair%3BLeischner%2C+Julie%3BKasper%2C+Douglas%3BGerber%2C+Robert%3BSambol%2C+Susan+P%3BParada%2C+Jorge+P%3BJohnson%2C+Stuart%3BGerding%2C+Dale+N&rft.aulast=Jabbar&rft.aufirst=Umair&rft.date=2010-01-01&rft.volume=31&rft.issue=6&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F652772 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Standard deviation; Chlorhexidine; Colony-forming cells; Statistical analysis; alcohols; Decontamination; Hand; Pathogens; Soaps; Spores; Hospitals; Alcohol; plains; Clostridium difficile DO - http://dx.doi.org/10.1086/652772 ER - TY - JOUR T1 - Management of Operation Iraqi Freedom and Operation Enduring Freedom veterans in a Veterans Health Administration chiropractic clinic: A case series AN - 744670711; 12589779 AB - Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) veterans commonly seek care for musculoskeletal complaints in Veterans Health Administration (VHA) facilities. Chiropractic services for musculoskeletal conditions have recently been introduced to VHA. No reports have been published on chiropractic care for OIF/OEF veterans. This study was designed to describe elements of the processes and outcomes of care for OIF/OEF veterans in a VHA chiropractic clinic. A retrospective review of consecutive cases consulted to one VHA chiropractic clinic was conducted. Thirty-one cases were identified. Consultations originated in primary care and specialty clinics that commonly manage musculoskeletal conditions. Military traumatic injury and posttraumatic stress disorder were common. Adverse effects of treatment were mild and transitory. In 19 cases (61%), a pain decrease above the threshold for minimally important change was reported. This article is the first description of health services delivered to OIF/OEF veterans in a VHA chiropractic clinic. Chiropractic management was safe in these cases, and results support the hypothesis that such management may be effective in certain OIF/OIF veterans. A better understanding of the characteristics of these particular patients and the processes of care received in VHA chiropractic clinics is needed to improve the clinical care of these veterans. JF - Journal of Rehabilitation Research and Development AU - Lisi, A J AD - Chiropractic Service, VA Connecticut Healthcare System, 950 Campbell Avenue, Building 2, 4th Floor East, West Haven, CT 06516, USA, Anthony.lisi@va.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 1 EP - 6 VL - 47 IS - 1 SN - 0748-7711, 0748-7711 KW - Health & Safety Science Abstracts KW - Injuries KW - Psychology KW - Reviews KW - pain KW - Military KW - musculoskeletal system KW - Side effects KW - Research programs KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744670711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Management+of+Operation+Iraqi+Freedom+and+Operation+Enduring+Freedom+veterans+in+a+Veterans+Health+Administration+chiropractic+clinic%3A+A+case+series&rft.au=Lisi%2C+A+J&rft.aulast=Lisi&rft.aufirst=A&rft.date=2010-01-01&rft.volume=47&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2009.07.0095 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Injuries; Psychology; Reviews; pain; Military; Research programs; Side effects; musculoskeletal system DO - http://dx.doi.org/10.1682/JRRD.2009.07.0095 ER - TY - JOUR T1 - Virginia (Ginny) DuPont, 19482009 AN - 742902617; 201004728 AB - An obituary for Virginia L. (Ginny) DuPont, a leader in the federal and medical library communities. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Clark, Nancy AU - Carter, Wendy N AD - Library Network Office, Department of Veterans Affairs, 4500 South Lancaster Road, Dallas, TX 75216; Email: nancy.clark@va.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 8 PB - Medical Library Association, Chicago, IL VL - 98 IS - 1 SN - 1536-5050, 1536-5050 KW - DuPont, Virginia L. KW - Librarians KW - Obituaries KW - article KW - 2.11: LIS - BIOGRAPHIES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742902617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Virginia+%28Ginny%29+DuPont%2C+19482009&rft.au=Clark%2C+Nancy%3BCarter%2C+Wendy+N&rft.aulast=Clark&rft.aufirst=Nancy&rft.date=2010-01-01&rft.volume=98&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/ L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2010-06-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Obituaries; Librarians ER - TY - JOUR T1 - Electronic and Personal Health Records: VA's Key to Patient Safety AN - 742894959; 201004580 AB - The move to electronic and personal health records (PHRs) is being spurred by new incentives offered by President Obama's administration. While the benefits to patients and health care organizations are great, implementation also presents many challenges and pitfalls. This article outlines the types of electronic health records and their uses, barriers to implementation, and issues patients should be aware of when contemplating compiling their own PHRs. A case report of the Veterans Healthcare Administration explains how it is moving toward an integrated health record that enhances patient safety and informed health care options. Adapted from the source document. JF - Journal of Consumer Health on the Internet AU - Schneider, Janet M AD - James A. Haley Veterans' Hospital, 13000 Bruce B. Downs Boulevard, Tampa, FL 33612 janet.schneider@va.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 12 EP - 22 PB - Taylor & Francis, Philadelphia PA VL - 14 IS - 1 SN - 1539-8285, 1539-8285 KW - Electronic health record, My HealtheVet, personal health record, Veterans Healthcare Administration KW - Health care KW - Medical records KW - Computerized records management KW - Military forces KW - article KW - 18.0: RECORDS MANAGEMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742894959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consumer+Health+on+the+Internet&rft.atitle=Electronic+and+Personal+Health+Records%3A+VA%27s+Key+to+Patient+Safety&rft.au=Schneider%2C+Janet+M&rft.aulast=Schneider&rft.aufirst=Janet&rft.date=2010-01-01&rft.volume=14&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consumer+Health+on+the+Internet&rft.issn=15398285&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Computerized records management; Medical records; Health care; Military forces ER - TY - JOUR T1 - Symptom complaints following combat-related traumatic brain injury: relationship to traumatic brain injury severity and posttraumatic stress disorder. AN - 742783717; pmid-19758488 AB - Patients with a history of mild (n = 134) or moderate-to-severe (n = 91) TBI were asked to complete the Neurobehavioral Symptom Inventory (NSI) and the Posttraumatic Stress Disorder Checklist. Consistent with prior research, significantly more postconcussion symptoms were endorsed by the mild group. After controlling for age, time since injury, and mechanism of injury, TBI severity continued to be significantly related to postconcussion complaints on the NSI. However, after controlling for these same variables, along with posttraumatic stress disorder symptom severity, there no longer were differences between the TBI severity groups. That is, patients with mild TBI did not endorse significantly more complaints (adjusted mean = 22.4) than the moderate-to-severe group (adjusted mean = 21.8). These findings suggest that much of the symptom complaints in mildly injured patients may be due to emotional distress. JF - Journal of the International Neuropsychological Society : JINS AU - Belanger, Heather G AU - Kretzmer, Tracy AU - Vanderploeg, Rodney D AU - French, Louis M AD - Department of Mental Health and Behavioral Sciences, James A. Haley VA, Tampa, FL 33612, USA. heather.belanger@va.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 194 EP - 199 VL - 16 IS - 1 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Severity of Illness Index KW - Young Adult KW - Analysis of Variance KW - Questionnaires KW - Military Personnel KW - Syndrome KW - Humans KW - Hospitals, Military KW - Checklist KW - Adult KW - Neuropsychological Tests KW - Male KW - Stress Disorders, Post-Traumatic -- etiology KW - Stress Disorders, Post-Traumatic -- psychology KW - Brain Injuries -- psychology KW - Combat Disorders -- complications KW - Brain Injuries -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742783717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Symptom+complaints+following+combat-related+traumatic+brain+injury%3A+relationship+to+traumatic+brain+injury+severity+and+posttraumatic+stress+disorder.&rft.au=Belanger%2C+Heather+G%3BKretzmer%2C+Tracy%3BVanderploeg%2C+Rodney+D%3BFrench%2C+Louis+M&rft.aulast=Belanger&rft.aufirst=Heather&rft.date=2010-01-01&rft.volume=16&rft.issue=1&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Diabetes-related changes in auditory brainstem responses. AN - 742782734; pmid-19904812 AB - OBJECTIVES/HYPOTHESIS: Determine effects on auditory brainstem response (ABR) of diabetes mellitus (DM) severity. STUDY DESIGN: A cross-sectional study investigating DM severity and ABR in military Veteran subjects with (166) and without (138) DM and with no more than moderate hearing loss. METHODS: Subjects were classified by three age tertiles (<50, 50-56, and 57+). DM severity was classified as insulin-dependent (IDDM), non-insulin-dependent (NIDDM), or no DM. Other DM measures included serum glucose, HbA1c, and several DM-related complications. ABR measures included wave I, III, and V latencies; I-III, III-V, and I-V latency intervals; and wave V amplitude; for each ear at three repetition rates (11, 51, and 71 clicks/second), and both polarities. Outcomes were stratified by age tertile and adjusted for pure tone threshold at 3 kHz. Repeated measures multivariate analysis of covariance modeled the ABR response at each repetition rate for DM severity (main effect) and hearing at 3 kHz (covariate). Modeled contrasts between ABR variables in subjects with and without DM were examined. RESULTS: Significant differences existed between no DM and IDDM groups in the younger tertile only. Adjusting for threshold at 3 kHz had minimal effect. Self-reported noise exposure was not related to ABR differences, but HbA1c and poor circulation were. CONCLUSIONS: IDDM is associated with an increased wave V latency, wave I-V interval, and reduced wave V amplitude among Veterans under 50 years. Results were related to several DM complications. JF - The Laryngoscope AU - Konrad-Martin, Dawn AU - Austin, Donald F AU - Griest, Susan AU - McMillan, Garnett P AU - McDermott, Daniel AU - Fausti, Stephen AD - Veterans Affairs Rehabilitation Research and Development Service, National Center for Rehabilitative Auditory Research, Portland Veterans Affairs Medical Center, Portland, Oregon 97239, USA. dawn.martin@va.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 150 EP - 158 VL - 120 IS - 1 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Diabetes Mellitus, Type 1 -- physiopathology KW - Cross-Sectional Studies KW - Humans KW - Diabetes Complications -- physiopathology KW - Hearing Loss -- complications KW - Adult KW - Aged KW - Middle Aged KW - Diabetes Mellitus, Type 2 -- physiopathology KW - Evoked Potentials, Auditory, Brain Stem KW - Diabetes Mellitus -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742782734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Diabetes-related+changes+in+auditory+brainstem+responses.&rft.au=Konrad-Martin%2C+Dawn%3BAustin%2C+Donald+F%3BGriest%2C+Susan%3BMcMillan%2C+Garnett+P%3BMcDermott%2C+Daniel%3BFausti%2C+Stephen&rft.aulast=Konrad-Martin&rft.aufirst=Dawn&rft.date=2010-01-01&rft.volume=120&rft.issue=1&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Clostridium difficile is associated with poor outcomes in patients with cirrhosis: A national and tertiary center perspective. AN - 742782152; pmid-19844204 AB - OBJECTIVES: Clostridium difficile-associated disease (CDAD) is associated with antibiotic use, acid suppression, and hospitalization, all of which occur frequently in cirrhosis. The aim was to define the effect of CDAD on outcomes and identify risk factors for its development in cirrhosis. METHODS: Case-control studies using the de-identified national (Nationwide Inpatient Sample, NIS) and an identified liver transplant center database of hospitalized cirrhotics with and without CDAD were performed. The NIS 2005 was queried for mortality, charges, and length of stay (LOS) in cirrhotics with/without CDAD. Outcomes of cirrhosis and infections were also analyzed. In the transplant center database, risk factors for CDAD were defined in hospitalized cirrhotics with/without CDAD who were age matched in a 1:2 ratio. RESULTS: The NIS 2005 included 1,165 cirrhotics with and 82,065 without CDAD. Cirrhotics with CDAD had a significantly higher mortality (13.8% vs. 8.2%, P<0.001), LOS (14.4 days vs. 6.7 days, P<0.001), and charges ($79,351 vs. $35,686, P<0.001) compared with those without CDAD. On multivariate analysis, CDAD was associated with higher mortality (odds ratio (OR) 1.55, 95% confidence interval (CI) 1.29-1.85), charges, and LOS despite controlling for cirrhosis complications and infections. In the transplant center database, 54 cirrhotics with and 108 cirrhotics without CDAD were included. Outpatient spontaneous bacterial peritonitis prophylaxis (35% vs. 13%, P=0.01), inpatient antibiotic (63% vs. 35%, P=0.0001), and proton pump inhibitor (PPI) use (74% vs. 31%, P=0.0001) were significantly higher in those with CDAD. CONCLUSIONS: Cirrhotics with CDAD have a higher mortality, LOS, and charges on the NIS 2005 compared with those without CDAD. Antibiotic and PPI use are risk factors for CDAD development in hospitalized cirrhotics. JF - The American journal of gastroenterology AU - Bajaj, Jasmohan S AU - Ananthakrishnan, Ashwin N AU - Hafeezullah, Muhammad AU - Zadvornova, Yelena AU - Dye, Alexis AU - McGinley, Emily L AU - Saeian, Kia AU - Heuman, Douglas AU - Sanyal, Arun J AU - Hoffmann, Raymond G AD - Department of Medicine, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, 23249, USA. jasmohan.bajaj@va.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 106 EP - 113 VL - 105 IS - 1 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Regression Analysis KW - Humans KW - Anti-Bacterial Agents -- adverse effects KW - Aged KW - Comorbidity KW - Length of Stay -- statistics & numerical data KW - Proton Pump Inhibitors -- adverse effects KW - Hospital Charges KW - Risk Factors KW - Hospital Mortality KW - Wisconsin -- epidemiology KW - Case-Control Studies KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Clostridium difficile KW - Liver Cirrhosis -- therapy KW - Outcome Assessment (Health Care) KW - Liver Cirrhosis -- complications KW - Enterocolitis, Pseudomembranous -- therapy KW - Liver Cirrhosis -- mortality KW - Enterocolitis, Pseudomembranous -- microbiology KW - Enterocolitis, Pseudomembranous -- mortality KW - Enterocolitis, Pseudomembranous -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742782152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Clostridium+difficile+is+associated+with+poor+outcomes+in+patients+with+cirrhosis%3A+A+national+and+tertiary+center+perspective.&rft.au=Bajaj%2C+Jasmohan+S%3BAnanthakrishnan%2C+Ashwin+N%3BHafeezullah%2C+Muhammad%3BZadvornova%2C+Yelena%3BDye%2C+Alexis%3BMcGinley%2C+Emily+L%3BSaeian%2C+Kia%3BHeuman%2C+Douglas%3BSanyal%2C+Arun+J%3BHoffmann%2C+Raymond+G&rft.aulast=Bajaj&rft.aufirst=Jasmohan&rft.date=2010-01-01&rft.volume=105&rft.issue=1&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - SuppNotes - Comment In: Am J Gastroenterol. 2010 Jan;105(1):114-6[20054307] N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Assessment of a Hepatitis Educational Group for Veterans with Substance Use Disorders AN - 742723075; 201010092 AB - Background: In 2005 the substance use disorders (SUD) clinic at the Minneapolis Veterans Affairs Medical Center launched the Liver Health Initiative in an effort to improve hepatitis education, screening, prevention, and treatment referral services for veterans receiving SUD services. One component of the Liver Health Initiative is an hour-long educational group; the Healthy Liver Group. Objectives: After the Healthy Liver Group was firmly established, an evaluation took place in order to measure: 1) change in patient knowledge, 2) participant satisfaction, and 3) attitudes toward hepatitis A and B vaccinations. Methods: From August 2007 to May 2008, 102 veterans filled out a paper survey before and after their experience in the Healthy Liver Group. Significance and Conclusions: The results of this survey show an increase in basic knowledge of hepatitis, high levels of patient satisfaction, and strong acceptance of vaccinations for hepatitis A and B. Overall, the survey indicates that the Healthy Liver Group is providing an important service and is generally well accepted by patients. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Hagedorn, Hildi AU - Leighton, Tabitha AU - Heim, Leeann AD - Substance Use Disorders Quality Enhancement Research Initiative, Minneapolis Veteran Affairs Medical Center, Minneapolis, Minnesota, USA hildi.hagedorn@va.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 57 EP - 60 PB - Taylor & Francis Inc., Philadelphia, PA VL - 36 IS - 1 SN - 0095-2990, 0095-2990 KW - Hepatitis KW - Veterans KW - Health initiatives KW - Substance abuse disorders KW - Liver KW - Hepatitis A KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742723075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Assessment+of+a+Hepatitis+Educational+Group+for+Veterans+with+Substance+Use+Disorders&rft.au=Hagedorn%2C+Hildi%3BLeighton%2C+Tabitha%3BHeim%2C+Leeann&rft.aulast=Hagedorn&rft.aufirst=Hildi&rft.date=2010-01-01&rft.volume=36&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.3109%2F00952990903572233 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-27 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Liver; Veterans; Substance abuse disorders; Hepatitis; Health initiatives; Hepatitis A DO - http://dx.doi.org/10.3109/00952990903572233 ER - TY - JOUR T1 - A Formative Evaluation of Organizational Readiness to Implement Nurse-Initiated HIV Rapid Testing in Two Veterans Health Administration Substance Use Disorder Clinics AN - 741612671; 201007401 AB - Within the Veterans Health Administration, substance use disorder clinics can be important locations for identifying HIV-infected patients. In this formative evaluation we assessed organizational readiness to implement a nurse-initiated HIV rapid test strategy in two Veterans Health Administration substance use disorder clinics. We conducted 34 quantitative surveys and 21 key informant interviews with front-line staff and management to assess attitudes regarding HIV testing in general and nurse-initiated HIV rapid testing specifically. We also assessed potential organizational impediments and facilitators to the implementation of nurse-initiated HIV rapid testing. Staff agreed that nurse-initiated HIV rapid testing is supported by research evidence, clinical experience, and patient need. Staff differed on the degree to which nurse-initiated HIV rapid test strategy fit within the substance use disorder clinic mission. We identified barriers to the implementation of nurse-initiated HIV rapid testing, including resource limitations, concerns of organizational readiness and patient acceptance of the nurse-initiated HIV rapid testing strategy. Despite these hurdles, the clinics are willing to adopt nurse-initiated HIV rapid testing if supported by appropriate modifications in organizational structure, HIV ordering policies, and specific changes in clinical practices. Adapted from the source document. JF - Journal of HIV/AIDS & Social Services AU - Henry, S Randal AU - Hagedorn, Hildi J AU - Feld, Jamie E AU - Golden, Joya F AU - Horns, Hana AU - Knapp, Herschel E AU - Anaya, Henry D AD - HIV/Hepatitis C QUERI, Center for the Study of Healthcare Provider Behavior, U.S. Department of Veterans Affairs Greater Los Angeles Health Services Research and Development (HSR&D) Center of Excellence, Veterans Health Administration Greater Los Angeles Healthcare System, Los Angeles, California, USA Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 7 EP - 26 PB - Haworth/Taylor & Francis Group, Philadelphia. PA VL - 9 IS - 1 SN - 1538-1501, 1538-1501 KW - Veterans KW - Substance Abuse KW - Acquired Immune Deficiency Syndrome KW - Organizational Structure KW - Patients KW - Health KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/741612671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+HIV%2FAIDS+%26+Social+Services&rft.atitle=A+Formative+Evaluation+of+Organizational+Readiness+to+Implement+Nurse-Initiated+HIV+Rapid+Testing+in+Two+Veterans+Health+Administration+Substance+Use+Disorder+Clinics&rft.au=Henry%2C+S+Randal%3BHagedorn%2C+Hildi+J%3BFeld%2C+Jamie+E%3BGolden%2C+Joya+F%3BHorns%2C+Hana%3BKnapp%2C+Herschel+E%3BAnaya%2C+Henry+D&rft.aulast=Henry&rft.aufirst=S&rft.date=2010-01-01&rft.volume=9&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Journal+of+HIV%2FAIDS+%26+Social+Services&rft.issn=15381501&rft_id=info:doi/10.1080%2F15381501003661513 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-06-07 N1 - Number of references - 21 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Substance Abuse; Veterans; Health; Patients; Organizational Structure DO - http://dx.doi.org/10.1080/15381501003661513 ER - TY - JOUR T1 - Chapter 30: historical aspects of the major neurological vitamin deficiency disorders: the water-soluble B vitamins. AN - 734127431; 19892133 AB - This historical review addresses major neurological disorders associated with deficiencies of water-soluble B vitamins: beriberi, Wernicke-Korsakoff syndrome, pellagra, neural tube defects, and subacute combined degeneration of the spinal cord. Beriberi: Beriberi was known for millennia in Asia, but was not described by a European until the 17th century when Brontius in the Dutch East Indies reported the progressive sensorimotor polyneuropathy. The prevalence of beriberi increased greatly in Asia with a change in the milling process for rice in the late 19th century. In the 1880s, Takaki demonstrated the benefits of dietary modification in sailors, and later instituted dietary reforms in the Japanese Navy, which largely eradicated beriberi from the Japanese Navy by 1887. In 1889 Eijkman in Java serendipitously identified dietary factors as a major contributor to "chicken polyneuritis," which he took to be an animal model for beriberi; the polyneuritis could be cured or prevented by feeding the chickens either unpolished rice or rice polishings. By 1901, Grijns, while continuing studies of beriberi in Java, suggested a dietary deficiency explanation for beriberi after systematically eliminating deficiencies of known dietary components and excluding a toxic effect. Wernicke-Korsakoff syndrome: In the late 1870s, Wernicke identified a clinicopathological condition with ophthalmoparesis, nystagmus, ataxia, and encephalopathy, associated with punctate hemorrhages symmetrically arranged in the grey matter around the third and fourth ventricles and the aqueduct of Sylvius. In the late 1880s, Korsakoff described a spectrum of cognitive disorders, including a confabulatory amnestic state following an agitated delirium, occurring in conjunction with peripheral polyneuropathy. Beginning around 1900, investigators recognized the close relationship between Korsakoff's psychosis, delirium tremens, and Wernicke's encephalopathy, but not until several decades later were Wernicke's encephalopathy, Korsakoff's psychosis, and beriberi all linked to the deficiency of a specific dietary factor, i.e. thiamin. Thiamin: Thiamin was crystallized from rice polishings by Jansen and Donath in 1926, and synthesized by Williams and Cline in 1936. In the late 1930s and early 1940s, characteristic pathological changes of Wernicke-Korsakoff syndrome were produced in animal models, the biochemical roles of thiamin in intermediary carbohydrate metabolism were elaborated by Peters and others, and the therapeutic benefits of thiamin for Wernicke-Korsakoff syndrome and beriberi were demonstrated. By the 1950s synthetic forms of the vitamin were produced cheaply, allowing both therapeutic administration and prevention with food enrichment. Pellagra and niacin: Pellagra was unknown prior to the introduction of maize into Europe from the New World. In the 18th century, Casàl and Frapolli described the clinical features of pellagra in Europe, and linked it with poverty and subsistence on nutritionally marginal corn-based diets. In the United States, pellagra became epidemic among poor Southerners in the early 20th century, in part because of economically-driven reliance on monotonous, nutritionally inadequate diets, combined with new manufacturing methods that removed vitamins from processed grain. From 1914-1929, Goldberger completed well-designed epidemiologic investigations, tested theories with human experiments, and utilized an animal model ("black tongue" in dogs) - all strongly supporting a dietary deficiency explanation for pellagra over prevailing toxic and infectious theories. Initial prevention and treatment approaches proved inadequate because of complex social issues linked to poverty, even after Goldberger and colleagues established that dried brewer's yeast could cure or prevent pellagra less expensively than dietary modification. During the depression, the collapse of cotton as an economically viable crop facilitated crop diversification, which contributed to an abrupt decline in pellagra mortality in the early 1930s. In 1937 Elvehjem isolated the P-P (pellagra preventive) factor, identified it as nicotinic acid (niacin), and demonstrated that nicotinic acid and nicotinic acid amide cure black tongue in dogs. Although clinical trials soon confirmed dramatic therapeutic effects in individual people, therapeutic administration of niacin had relatively little impact on population-level morbidity and mortality. Vitamin fortification of foodstuffs during World War II ultimately eradicated endemic pellagra in the United States. In the 1940s and 1950s, with expanded biochemical knowledge, pellagra was reformulated as a deficiency disease due to inadequate niacin and its amino acid precursor tryptophan. Neural tube defects and folate: Folate deficiency was initially recognized clinically as a macrocytic anemia in the 1920s, and only clearly separated from pernicious anemia by the mid-20th century. When folic acid was isolated and synthesized in the 1940s, it was shown to correct the macrocytic anemia associated with pernicious anemia, while the neurological manifestations progressed. In the 1950s and 1960s, the biochemical role of folates in transferring single carbon units was elucidated. Beginning in the 1960s, folate deficiency was increasingly recognized as the major cause of preventable neural tube defects. In the early 1990s well-designed randomized trials established that folate supplementation could prevent neural tube defects. Trial data, collectively indicating that periconceptual folate administration reduces both the occurrence and recurrence risks of neural tube defects by at least 70%, helped establish governmental recommendations concerning folic acid intake and health policy concerning vitamin fortification of foodstuffs. When dietary modification and supplementation strategies proved inadequate, folic acid food fortification was legally mandated in the US in the late 1990s, which significantly improved population folate status and produced an abrupt decline (20%-27%) in the prevalence of neural tube defects at birth. Recent studies have established genetic predispositions for neural tube defects, including both infant and maternal gene polymorphisms for enzymes involved in folate-dependent homocysteine metabolism, which help explain how the genotype of the mother, the genotype of the unborn child, and environmental factors (e.g. folate intake) can all impact on the risk of neural tube defects. Subacute combined degeneration and B(12) deficiency: Pernicious anemia was recognized clinically in the mid-19th century by Addison, but the most important neurological manifestation - subacute combined degeneration of the spinal cord - was not recognized clinically and linked with pernicious anemia until the end of the 19th century, particularly by Lichtheim, Putnam, and Dana. At the beginning of the 20th century, pernicious anemia and the associated subacute combined degeneration of the spinal cord were considered, by many investigators, to result from infectious or toxic causes. During the first quarter of the 20th century, various therapies were employed, but, with the possible exception of transfusion, were largely ineffective. In the 1920s, Minot and Murphy showed that large quantities of ingested liver could be used to effectively treat pernicious anemia, and specifically could improve or prevent progression of neurological manifestations, and could extend life expectancy beyond 2 years. Beginning in the late 1920s, Castle demonstrated that a substance elaborated by the gastric mucosa ("intrinsic factor") was essential for the absorption of a dietary factor ("extrinsic factor," later shown to be vitamin B(12)) needed to prevent pernicious anemia. Over two decades, from the late 1920s until the late 1940s, increasingly potent liver extracts were manufactured that could be given either intramuscularly or intravenously. In 1947, vitamin B(12) was isolated by Folkers and colleagues, and nearly simultaneously by Smith. Shortly thereafter the therapeutic efficacy of vitamin B(12) on subacute combined degeneration was demonstrated by West and Reisner and others. By 1955, Hodgkin determined the molecular structure of cyanocobalamin using computer-assisted x-ray crystallography, allowing complete chemical synthesis of vitamin B(12) in 1960 by an international consortium. Beginning in the late 1950s, the absorption and biochemistry of vitamin B(12) were elaborated, and several lines of evidence converged to support an autoimmune basis for pernicious anemia. JF - Handbook of clinical neurology AU - Lanska, Douglas J AD - Department of Neurology, Veterans Affairs Medical Center, Tomah, WI 54660, USA. douglas.lanska@med.va.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 445 EP - 476 VL - 95 SN - 0072-9752, 0072-9752 KW - Vitamin B Complex KW - 12001-76-2 KW - Index Medicus KW - Animals KW - History, 20th Century KW - Humans KW - History, 18th Century KW - History, 19th Century KW - History, 17th Century KW - History, 16th Century KW - Vitamin B Complex -- therapeutic use KW - Avitaminosis -- complications KW - Nervous System Diseases -- etiology KW - Avitaminosis -- history KW - Vitamin B Complex -- metabolism KW - Nervous System Diseases -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734127431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Handbook+of+clinical+neurology&rft.atitle=Chapter+30%3A+historical+aspects+of+the+major+neurological+vitamin+deficiency+disorders%3A+the+water-soluble+B+vitamins.&rft.au=Lanska%2C+Douglas+J&rft.aulast=Lanska&rft.aufirst=Douglas&rft.date=2010-01-01&rft.volume=95&rft.issue=&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Handbook+of+clinical+neurology&rft.issn=00729752&rft_id=info:doi/10.1016%2FS0072-9752%2808%2902130-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-16 N1 - Date created - 2009-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S0072-9752(08)02130-1 ER - TY - JOUR T1 - Chapter 29: historical aspects of the major neurological vitamin deficiency disorders: overview and fat-soluble vitamin A. AN - 734127418; 19892132 AB - The vitamine doctrine: Although diseases resulting from vitamin deficiencies have been known for millennia, such disorders were generally attributed to toxic or infectious causes until the "vitamin doctrine" was developed in the early 20th century. In the late-19th century, a physiologically complete diet was believed to require only sufficient proteins, carbohydrates, fats, inorganic salts, and water. From 1880-1912, Lunin, Pekelharing, and Hopkins found that animals fed purified mixtures of known food components failed to grow or even lost weight and died, unless the diet was supplemented with small amounts of milk, suggesting that "accessory food factors" are required in trace amounts for normal growth. By this time, Funk suggested that deficiencies of trace dietary factors, which he labeled "vitamines" on the mistaken notion that they were "vital amines," were responsible for such diseases as beriberi, scurvy, rickets, and pellagra. Vitamin A deficiency eye disease: Night blindness was recognized by the ancient Egyptians and Greeks, and many authorities from Galen onward advocated liver as a curative. Outbreaks of night blindness were linked to nutritional causes in the 18th and 19th centuries by von Bergen, Schwarz, and others. Corneal ulceration was reported in 1817 by Magendie among vitamin A-deficient dogs fed for several weeks on a diet limited to sugar and water, although he erroneously attributed this to a deficiency of dietary nitrogen (i.e. protein). Subsequently, corneal epithelial defects, often in association with night blindness, were recognized in malnourished individuals subsisting on diets now recognizable as deficient in vitamin A by Budd, Livingstone, von Hubbenet, Bitot, Mori, Ishihari, and others. During World War I, Bloch conducted a controlled clinical trial of different diets among malnourished Danish children with night blindness and keratomalacia and concluded that whole milk, butter, and cod-liver oil contain a fat-soluble substance that protects against xerophthalmia. Early retinal photochemistry: In the 1870s, Boll found that light causes bleaching of the retinal pigment, and suggested that the outer segments of the rods contain a substance that conveys an impression of light to the brain by a photochemical process. Shortly thereafter, Kühne demonstrated that the bleaching process depends upon light, and was reversible if the retinal pigment epithelium was intact. Kühne proposed an "optochemical hypothesis," a prescient concept of photochemical transduction, attributing vision to a photochemical change in visual purple (rhodopsin) with resulting chemical products stimulating the visual cells and thereby conveying a visual image. Vitamin A: In 1913, Ishihara proposed that a "fatty substance" in blood is necessary for synthesis of both rhodopsin and the surface layer of the cornea, and that night blindness and keratomalacia develop when this substance is deficient. That year McCollum and Davis (and almost simultaneously Mendel and Osborne) discovered a fat-soluble accessory food factor (later called "fat-soluble A") distinct from the water-soluble anti-beriberi factor (later called "fat-soluble B"). By 1922 McCollum and colleagues distinguished two vitamins within the fat-soluble fraction, later named vitamins A and D. In 1925 Fridericia and Holm directly linked vitamin A to night blindness in animal experiments using rats, and in 1929 Holm demonstrated the presence of vitamin A in retinal tissue. In the 1930s, Moore, Karrer, Wald, and others established the provitamin role of beta-carotene. Karrer and colleagues isolated beta-carotene (the main dietary precursor of vitamin A) and retinol (vitamin A), and determined their chemical structures. In 1947, Isler and colleagues completed the full chemical synthesis of vitamin A. Modern retinal photochemistry: Beginning in the 1930s, Wald and colleagues greatly elaborated the photochemistry of vision, with the discovery of the visual cycle of vitamin A, demonstration that rhodopsin is decomposed by light into retinal (the aldehyde form of vitamin A) and a protein (opsin), elaboration of the enzymatic conversions of various elements in the rhodopsin system, and discovery that the rhodopsin system is dependent on a photoisomerization of retinal. In 1942, Hecht and colleagues demonstrated that a single photon could trigger excitation in a rod. In 1965, Wald suggested that a large chemical amplification was necessary for this degree of light sensitivity, likely by a cascade of enzymatic reactions. Later studies elaborated this cascade and found that an intermediary in the photoisomerization of retinal interacts with transducin, a G-protein, to activate phosphodiesterases that control cyclic GMP levels, which in turn modulate the release of neurotransmitter from the rod cell. Public health: Although the availability of vitamin A through food fortification and medicinal supplements virtually eliminated ocular vitamin A deficiency from developed countries by the second half of the 20th century, vitamin A deficiency remains a serious problem in developing countries as indicated by global surveys beginning in the 1960s. Millions of children were shown to be vitamin A deficient, with resultant blindness, increased susceptibility to infection, and increased childhood mortality. Beginning in the 1960s, intervention trials showed that vitamin A deficiency disorders could be prevented in developing countries with periodic vitamin A dosing, and in the 1980s and 1990s, large randomized, double-blind, placebo-controlled clinical trials demonstrated the marked efficacy of vitamin A supplementation in reducing childhood mortality. JF - Handbook of clinical neurology AU - Lanska, Douglas J AD - Department of Neurology, Veterans Affairs Medical Center, Tomah, WI 54660, USA. douglas.lanska@med.va.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 435 EP - 444 VL - 95 SN - 0072-9752, 0072-9752 KW - Vitamin A KW - 11103-57-4 KW - Index Medicus KW - Malnutrition -- etiology KW - Vitamin A Deficiency -- etiology KW - Night Blindness -- etiology KW - Animals KW - Malnutrition -- complications KW - Night Blindness -- complications KW - History, 20th Century KW - Humans KW - History, 19th Century KW - Vitamin A Deficiency -- history KW - Night Blindness -- history KW - Vitamin A Deficiency -- complications KW - Vitamin A -- therapeutic use KW - Avitaminosis -- complications KW - Avitaminosis -- history KW - Vitamin A -- metabolism KW - Nervous System Diseases -- history KW - Vitamin A -- history KW - Nervous System Diseases -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734127418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Handbook+of+clinical+neurology&rft.atitle=Chapter+29%3A+historical+aspects+of+the+major+neurological+vitamin+deficiency+disorders%3A+overview+and+fat-soluble+vitamin+A.&rft.au=Lanska%2C+Douglas+J&rft.aulast=Lanska&rft.aufirst=Douglas&rft.date=2010-01-01&rft.volume=95&rft.issue=&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Handbook+of+clinical+neurology&rft.issn=00729752&rft_id=info:doi/10.1016%2FS0072-9752%2808%2902129-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-16 N1 - Date created - 2009-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S0072-9752(08)02129-5 ER - TY - JOUR T1 - Pain, Coping and Health Care Utilization in Younger and Older Adults with Sickle Cell Disease AN - 57349163; 201008156 AB - Sickle cell disease is characterized by acute pain crises. Pain, chronic medical problems, utilization and coping were compared in younger vs older patients using questionnaires and medical record review. Groups reported similar pain intensity and medical conditions. The pattern of utilization differed such that older patients attended outpatient clinic, and younger patients went to the Emergency Department. Younger patients were more likely to cope by ignoring pain, or by using heat, cold or massage. Older patients were more likely to pray and hope. We conclude that age plays an important role in the utilization and coping of sickle cell patients. [Copyright Sage Publications Ltd.] JF - Journal of Health Psychology AU - Sanders, Kathryn A AU - Labott, Susan M AU - Molokie, Robert AU - Shelby, Sarah R AU - Desimone, Joseph AD - VA Connecticut Healthcare System & Yale University School of Medicine, USA kathryn.sanders@va.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 131 EP - 137 PB - Sage Publications, London UK VL - 15 IS - 1 SN - 1359-1053, 1359-1053 KW - coping health care utilization pain sickle cell disease KW - Chronic pain KW - Sickle cell anaemia KW - Massage KW - Coping KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57349163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Psychology&rft.atitle=Pain%2C+Coping+and+Health+Care+Utilization+in+Younger+and+Older+Adults+with+Sickle+Cell+Disease&rft.au=Sanders%2C+Kathryn+A%3BLabott%2C+Susan+M%3BMolokie%2C+Robert%3BShelby%2C+Sarah+R%3BDesimone%2C+Joseph&rft.aulast=Sanders&rft.aufirst=Kathryn&rft.date=2010-01-01&rft.volume=15&rft.issue=1&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Psychology&rft.issn=13591053&rft_id=info:doi/10.1177%2F1359105309345554 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JHPSFC N1 - SubjectsTermNotLitGenreText - Chronic pain; Coping; Sickle cell anaemia; Helpseeking; Massage DO - http://dx.doi.org/10.1177/1359105309345554 ER - TY - JOUR T1 - Depression and Geographic Status as Predictors for Coronary Artery Bypass Surgery Outcomes AN - 57342108; 201006483 AB - Purpose: To examine the relationships between depression, geographic status, and clinical outcomes following a coronary artery bypass grafting (CABG) surgery. Methods: Using the 2004 Nationwide Inpatient Sample database, we identified 63,061 discharge records of patients who underwent a primary CABG surgery (urban 57,247 and rural 5,814). We analyzed 7 demographic variables, 19 preoperative medical and psychiatric variables, and 2 outcome variables (ie, in-hospital mortality and length of stay). Logistic regression and multivariable regression analyses were used to assess urban-rural status and depression as independent predictors of in-hospital mortality and length of stay. Findings: Rural patients were more likely to have a comorbid depression diagnosis compared to urban patients (urban = 19.4%, rural = 21.4%, P < .001). After adjusting for confounding factors, having a comorbid depression diagnosis (B= 1.10, P < .001) and residing in a rural area (B= .986, P < .05) were associated with an increased length of in-hospital stay following CABG surgery. Furthermore, having a depression diagnosis (OR = 1.63, 95% CI = 1.45-2.21) and residing in a rural area (OR = 1.43, 95% CI = .896-1.45) were associated with an increased likelihood of in-hospital mortality. Conclusions: Rural patients were more likely than urban ones to have a depression diagnosis. Depression was a significant independent predictor of both in-hospital mortality and length of stay for patients receiving CABG surgery. Also, rural patients had increased lengths of in-hospital stay as well as in-hospital mortality rates compared to those who resided in urban areas. Adapted from the source document. JF - The Journal of Rural Health AU - Dao, Tam K AU - Chu, Danny AU - Springer, Justin AU - Hiatt, Emily AU - Nguyen, Quang AD - Department of Educational Psychology, University of Houston, Houston, Texas tam.dao@va.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 36 EP - 43 PB - National Rural Health Association, Kansas City MO VL - 26 IS - 1 SN - 0890-765X, 0890-765X KW - Mortality KW - Diagnosis KW - Depression KW - Surgery KW - Length of stay KW - Rural communities KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57342108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health&rft.atitle=Depression+and+Geographic+Status+as+Predictors+for+Coronary+Artery+Bypass+Surgery+Outcomes&rft.au=Dao%2C+Tam+K%3BChu%2C+Danny%3BSpringer%2C+Justin%3BHiatt%2C+Emily%3BNguyen%2C+Quang&rft.aulast=Dao&rft.aufirst=Tam&rft.date=2010-01-01&rft.volume=26&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2009.00263.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JRHEEX N1 - SubjectsTermNotLitGenreText - Depression; Rural communities; Surgery; Mortality; Diagnosis; Length of stay DO - http://dx.doi.org/10.1111/j.1748-0361.2009.00263.x ER - TY - JOUR T1 - Extranasal Methicillin-Resistant Staphylococcus aureus Colonization at Admission to an Acute Care Veterans Affairs Hospital AN - 21502267; 12491740 AB - Objective. To evaluate the prevalence of and risk factors for extranasal methicillin-resistant Staphylococcus aureus (MRSA) colonization and its relationship to nasal colonization among veterans hospitalized for acute care. Design. Prospective observational study. Setting. Veterans Affairs (VA) acute care hospital in Boston, Massachusetts. Patients. Convenience sample of 150 patients hospitalized within the previous 36 hours and screened for nasal MRSA who were not known to have an active MRSA infection or MRSA isolates recovered from a wound during the past 12 months. Methods. Potential risk factors for MRSA colonization were assessed, and oropharynx, axilla, hand, perirectal, wound, and catheter insertion site samples were obtained for culture. MRSA was identified in chromogenic agar and confirmed by use of routine culture techniques. Nasal MRSA colonization was detected by means of polymerase chain reaction (PCR). Results. Nasal swab samples analyzed by use of PCR yielded results positive for MRSA in 16 (11%) of 150 patients. Extranasal cultures yielded positive results for 3 (2%) of 134 patients who tested negative for nasal MRSA colonization and for 9 (56%) of 16 patients who tested positive for nasal MRSA colonization (odds ratio [OR], 56.1 [95% confidence interval {CI}, 12.4-254.6]; [image]). The oropharynx was the most commonly colonized extranasal site (10 patients [7%]). Independent risk factors for extranasal MRSA colonization included nasal MRSA colonization (OR, 66.9 [95% CI, 11.8-379.7]; [image]) and end-stage hepatic disease (OR, 98.5 [95% CI, 3.1-3,112.4]; [image]). Conclusions. Extranasal MRSA colonization is infrequent among veterans admitted for acute care to VA Boston Healthcare System. Extranasal MRSA colonization was strongly associated with nasal MRSA colonization, which suggests that the VA MRSA Prevention Initiative is not missing a large number of MRSA-colonized patients by focusing on nasal-only screening. JF - Infection Control and Hospital Epidemiology AU - Baker, Stacey E AU - Brecher, Stephen M AU - Robillard, Ernest AU - Strymish, Judith AU - Lawler, Elizabeth AU - Gupta, Kalpana AD - Veterans Affairs Boston Health Care System, Boston University School of Medicine, Harvard Medical School, and the Massachusetts Veterans Epidemiology and Research Center, Boston, Massachusetts., kalpana.gupta@va.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 42 EP - 46 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 31 IS - 1 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - Agar KW - Oropharynx KW - antibiotic resistance KW - Drug resistance KW - Infection KW - USA, Massachusetts, Boston KW - Colonization KW - Risk factors KW - infection KW - prevention KW - Polymerase chain reaction KW - medical instruments KW - Staphylococcus aureus KW - Liver diseases KW - Hand KW - colonization KW - Wounds KW - Health care KW - Catheters KW - Hospitals KW - R2 23060:Medical and environmental health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21502267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Extranasal+Methicillin-Resistant+Staphylococcus+aureus+Colonization+at+Admission+to+an+Acute+Care+Veterans+Affairs+Hospital&rft.au=Baker%2C+Stacey+E%3BBrecher%2C+Stephen+M%3BRobillard%2C+Ernest%3BStrymish%2C+Judith%3BLawler%2C+Elizabeth%3BGupta%2C+Kalpana&rft.aulast=Baker&rft.aufirst=Stacey&rft.date=2010-01-01&rft.volume=31&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F649222 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Agar; Colonization; Liver diseases; Oropharynx; Risk factors; Drug resistance; Catheters; Hand; Polymerase chain reaction; Infection; Wounds; Hospitals; Health care; antibiotic resistance; prevention; infection; medical instruments; colonization; Staphylococcus aureus; USA, Massachusetts, Boston DO - http://dx.doi.org/10.1086/649222 ER - TY - JOUR T1 - Risk Factors Associated with Methicillin Resistance among Staphylococcus aureus Infections in Veterans AN - 21502242; 12491739 AB - Background. Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging concern in infectious disease practice. Although MRSA infections occur in a wide variety of anatomic sites, the majority of studies considering the risk factors for methicillin resistance among S. aureus infections have focused on MRSA bacteremia. Objective. To describe risk factors associated with methicillin resistance among S. aureus infections at different anatomic sites. Methods. We collected information on the demographic and clinical characteristics of patients examined at the Atlanta Veterans Affairs Medical Center with S. aureus infections during the period from June 2007 through May 2008. We used multivariate logistic regression to describe factors significantly associated with methicillin resistance. Results. There were 568 cases of S. aureus infection among 528 patients. We identified 352 cases (62%) of MRSA infection and 216 cases (38%) of methicillin-sensitive S. aureus infection. The adjusted odds of methicillin resistance were higher among infections that occurred among patients who had a prior history of MRSA infection (odds ratio [OR], 3.9 [95% confidence interval {CI}, 2.3-6.4]) or resided in a long-term care facility during the past 12 months (OR, 2.0 [95% CI, 1.0-4.0]) but were lower for infections that occurred among patients who had undergone a biopsy procedure during the past 12 months (OR, 0.7 [95% CI, 0.6-0.9]). Most cases of infection were community-onset infections (523 [92%] of 568 cases), and about one-half (278 [49%]) were not healthcare associated. Conclusions. Compared with previous studies of methicillin resistance among patients with S. aureus bacteremia, we found similar factors to be associated with methicillin resistance among S. aureus isolates recovered from more diverse anatomic sites of infection. Of note, nearly one-half of our cases of MRSA infection were not healthcare associated. JF - Infection Control and Hospital Epidemiology AU - McCarthy, Natalie L AU - Sullivan, Patrick S AU - Gaynes, Robert AU - Rimland, David AD - Rollins School of Public Health and the School of Medicine, Emory University, and the Veterans Affairs Medical Center, Atlanta, Georgia., david.rimland@va.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 36 EP - 41 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 31 IS - 1 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - demography KW - Historical account KW - antibiotic resistance KW - Drug resistance KW - Biopsy KW - Infection KW - Demography KW - Methicillin KW - Infectious diseases KW - Risk factors KW - infection KW - Staphylococcus aureus KW - long-term care KW - Bacteremia KW - Health care KW - USA, Georgia, Atlanta KW - Hospitals KW - R2 23060:Medical and environmental health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21502242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Risk+Factors+Associated+with+Methicillin+Resistance+among+Staphylococcus+aureus+Infections+in+Veterans&rft.au=McCarthy%2C+Natalie+L%3BSullivan%2C+Patrick+S%3BGaynes%2C+Robert%3BRimland%2C+David&rft.aulast=McCarthy&rft.aufirst=Natalie&rft.date=2010-01-01&rft.volume=31&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F649017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Demography; Methicillin; Infectious diseases; Risk factors; Drug resistance; Bacteremia; Biopsy; Infection; Hospitals; demography; Historical account; long-term care; Health care; antibiotic resistance; infection; Staphylococcus aureus; USA, Georgia, Atlanta DO - http://dx.doi.org/10.1086/649017 ER - TY - JOUR T1 - Safety and Antibody Response, Including Antibody Persistence for 5 Years, after Primary Vaccination or Revaccination with Pneumococcal Polysaccharide Vaccine in Middle-Aged and Older Adults AN - 21479823; 12491900 AB - Background. This study assessed antibody levels for 5 years after primary vaccination or revaccination with 23-valent pneumococcal polysaccharide vaccine (PN23). Methods. Subjects were enrolled into 4 study groups by age (50-64 or [image]65 years) and prior vaccination status (no prior vaccination or 1 vaccination 3-5 years previously). Blood was obtained on day 0 (before primary vaccination or revaccination), day 30, day 60, and annually during years 2-5. Levels of immunoglobulin G (IgG) to 8 vaccine serotypes were measured by enzyme-linked immunosorbent assay. Results. Of 1008 enrolled subjects, 551 completed year 5. For each serotype and age group, baseline geometric mean concentrations (GMCs) of IgG were higher in revaccination than primary vaccination subjects. Primary vaccination or revaccination with PN23 induced significant increases in levels of antibody to all serotypes tested. Although day 30 and 60 antibody levels tended to be modestly lower after revaccination, study groups had similar GMCs at later time points. For serotypes 4, 6B, 8, 9V, 12F, 14, and 23F, GMCs during years 2-5 after primary vaccination or revaccination remained higher than in vaccine-naive persons. Levels of antibody to serotype 3 returned to baseline by year 2. Conclusions. Both primary vaccination and revaccination with PN23 induce antibody responses that persist during 5 years of observation. JF - Journal of Infectious Diseases AU - Musher, Daniel M AU - Manoff, Susan B AU - Liss, Charlie AU - McFetridge, Richard D AU - Marchese, Rocio D AU - Bushnell, Bonnie AU - Alvarez, Frances AU - Painter, Carla AU - Blum, Michael D AU - Silber, Jeffrey L AD - Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, Texas, Daniel.Musher@va.gov Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 516 EP - 524 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 201 IS - 4 SN - 0022-1899, 0022-1899 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Blood KW - Streptococcus pneumoniae KW - Age KW - Enzyme-linked immunosorbent assay KW - Serotypes KW - Immunoglobulin G KW - Vaccines KW - Antibody response KW - Polysaccharides KW - Vaccination KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21479823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Safety+and+Antibody+Response%2C+Including+Antibody+Persistence+for+5+Years%2C+after+Primary+Vaccination+or+Revaccination+with+Pneumococcal+Polysaccharide+Vaccine+in+Middle-Aged+and+Older+Adults&rft.au=Musher%2C+Daniel+M%3BManoff%2C+Susan+B%3BLiss%2C+Charlie%3BMcFetridge%2C+Richard+D%3BMarchese%2C+Rocio+D%3BBushnell%2C+Bonnie%3BAlvarez%2C+Frances%3BPainter%2C+Carla%3BBlum%2C+Michael+D%3BSilber%2C+Jeffrey+L&rft.aulast=Musher&rft.aufirst=Daniel&rft.date=2010-01-01&rft.volume=201&rft.issue=4&rft.spage=516&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F649839 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Blood; Enzyme-linked immunosorbent assay; Age; Serotypes; Immunoglobulin G; Antibody response; Vaccines; Polysaccharides; Vaccination; Streptococcus pneumoniae DO - http://dx.doi.org/10.1086/649839 ER - TY - JOUR T1 - Use of Antithrombotic Agents Among U.S. Stroke Survivors, 2000-2006 AN - 21339035; 11789050 AB - Background - Secondary stroke prevention guidelines recommend antithrombotic agents such as over-the-counter aspirin, prescription antiplatelet agents, or anticoagulant agents. Purpose - The study was designed to measure whether use of outpatient antithrombotic agents is increasing among stroke survivors. Methods - The sample consisted of 4168 people who self-reported cerebrovascular disease and who participated in the Medical Expenditure Panel Survey, an annual representative sample of the U.S., during the years 2000-2006. Use of antithrombotic agents was calculated from face-to-face interviews about the use of aspirin and from pharmacies about the use of prescription medications. Cochran-Armitage tests were used to detect temporal trends and multivariate models to identify predictors of use of antithrombotic agents. Results - Pooling results across the 7 years, it was found that 57% were taking aspirin, 66% were using any antiplatelet agent, and 75% were using any antithrombotic agent. After excluding people who said aspirin was unsafe, 81% were using any antithrombotic agent. During the study period, use of prescription antiplatelet agents increased (p65 years, male gender, non-Hispanic ethnicity, having a usual source of care, and poor or fair health status were associated with use of an antithrombotic agent (p<0.05). Conclusions - Although a high percentage of stroke survivors appear to use an antithrombotic agent, further research should investigate whether and how to improve care among the remaining 20% of stroke survivors, particularly among younger, female, and Hispanic patients. JF - American Journal of Preventive Medicine AU - Cheng, Eric M AU - Cohen, Stanley N AU - Lee, Martin L AU - Vassar, Stefanie D AU - Chen, Alex Y AD - Department of Neurology, Health Services Research Program, David Geffen School of Medicine, University of California, Los Angeles, California, eric.cheng@va.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 47 EP - 53 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 38 IS - 1 SN - 0749-3797, 0749-3797 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Anticoagulants KW - Aspirin KW - Cerebrovascular diseases KW - Stroke KW - Ethnic groups KW - Models KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21339035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Use+of+Antithrombotic+Agents+Among+U.S.+Stroke+Survivors%2C+2000-2006&rft.au=Cheng%2C+Eric+M%3BCohen%2C+Stanley+N%3BLee%2C+Martin+L%3BVassar%2C+Stefanie+D%3BChen%2C+Alex+Y&rft.aulast=Cheng&rft.aufirst=Eric&rft.date=2010-01-01&rft.volume=38&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2009.08.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Anticoagulants; Aspirin; Cerebrovascular diseases; Stroke; Ethnic groups; Models DO - http://dx.doi.org/10.1016/j.amepre.2009.08.029 ER - TY - JOUR T1 - Three Decades of ?-Lactamase Inhibitors AN - 21333675; 11915213 AB - Summary: Since the introduction of penicillin, ?-lactam antibiotics have been the antimicrobial agents of choice. Unfortunately, the efficacy of these life-saving antibiotics is significantly threatened by bacterial ?-lactamases. ?-Lactamases are now responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems. In order to overcome ?-lactamase-mediated resistance, ?-lactamase inhibitors (clavulanate, sulbactam, and tazobactam) were introduced into clinical practice. These inhibitors greatly enhance the efficacy of their partner ?-lactams (amoxicillin, ampicillin, piperacillin, and ticarcillin) in the treatment of serious Enterobacteriaceae and penicillin-resistant staphylococcal infections. However, selective pressure from excess antibiotic use accelerated the emergence of resistance to ?-lactam-?-lactamase inhibitor combinations. Furthermore, the prevalence of clinically relevant ?-lactamases from other classes that are resistant to inhibition is rapidly increasing. There is an urgent need for effective inhibitors that can restore the activity of ?-lactams. Here, we review the catalytic mechanisms of each ?-lactamase class. We then discuss approaches for circumventing ?-lactamase-mediated resistance, including properties and characteristics of mechanism-based inactivators. We next highlight the mechanisms of action and salient clinical and microbiological features of ?-lactamase inhibitors. We also emphasize their therapeutic applications. We close by focusing on novel compounds and the chemical features of these agents that may contribute to a QUOTATION_MARKsecond generationQUOTATION_MARK of inhibitors. The goal for the next 3 decades will be to design inhibitors that will be effective for more than a single class of ?-lactamases. JF - Clinical Microbiology Reviews AU - Drawz, Sarah M AU - Bonomo, Robert A Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 160 EP - 201 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 23 IS - 1 SN - 0893-8512, 0893-8512 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Cephalosporins KW - Amoxicillin KW - Ampicillin KW - Carbapenems KW - Therapeutic applications KW - Tazobactam KW - Antibiotics KW - Infection KW - Penicillin KW - Antimicrobial agents KW - Sulbactam KW - ticarcillin KW - Inactivators KW - Piperacillin KW - Enterobacteriaceae KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21333675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Reviews&rft.atitle=Three+Decades+of+%3F-Lactamase+Inhibitors&rft.au=Drawz%2C+Sarah+M%3BBonomo%2C+Robert+A&rft.aulast=Drawz&rft.aufirst=Sarah&rft.date=2010-01-01&rft.volume=23&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Reviews&rft.issn=08938512&rft_id=info:doi/10.1128%2FCMR.00037-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cephalosporins; Amoxicillin; Therapeutic applications; Carbapenems; Ampicillin; Antibiotics; Tazobactam; Infection; Penicillin; Sulbactam; Antimicrobial agents; ticarcillin; Inactivators; Piperacillin; Enterobacteriaceae DO - http://dx.doi.org/10.1128/CMR.00037-09 ER - TY - JOUR T1 - Invited Commentary: Genetic Variants and Individual- and Societal-Level Risk Factors AN - 21276675; 11832204 AB - Over the past decade, leading epidemiologists have noted the importance of social factors in studying and understanding the distribution and determinants of disease in human populations; but to what extent are epidemiologic studies integrating genetic information and other biologic variables with information about individual-level risk factors and group-level or societal factors related to the broader residential, behavioral, or cultural context? There remains a need to consider ways to integrate genetic information with social and contextual information in epidemiologic studies, partly to combat the overemphasis on the importance of genetic factors as determinants of disease in human populations. Even in genome-wide association studies of coronary heart disease and other common complex diseases, only a small proportion of heritability is explained by the genetic variants identified to date. It is possible that familial clustering due to genetic factors has been overestimated and that important environmental or social influences (acting alone or in combination with genetic variants) have been overlooked. The accompanying article by Bressler et al. (Am J Epidemiol. 2010; 171(1):14-23) highlights some of these important issues. JF - American Journal of Epidemiology AU - Coughlin, Steven S Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 24 EP - 26 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 171 IS - 1 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - coronary disease KW - genetic variation KW - genetics KW - genomics KW - heart diseases KW - myocardial infarction KW - polymorphism, single nucleotide KW - human populations KW - Cardiovascular diseases KW - culture KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21276675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Invited+Commentary%3A+Genetic+Variants+and+Individual-+and+Societal-Level+Risk+Factors&rft.au=Coughlin%2C+Steven+S&rft.aulast=Coughlin&rft.aufirst=Steven&rft.date=2010-01-01&rft.volume=171&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwp379 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Cardiovascular diseases; human populations; culture DO - http://dx.doi.org/10.1093/aje/kwp379 ER - TY - JOUR T1 - Antiviral Therapy Completion and Response Rates Among Hepatitis C Patients With and Without Schizophrenia AN - 1038601046; 17107018 AB - Background: Despite disproportionately high rates of hepatitis C (HCV) among patients with severe mental illness, to date, there is scant empirical data available regarding antiviral therapy outcomes within this population. Objective: To compare antiviral therapy completion and response rates between HCV patients with vs those without schizophrenia (SCHZ). Methods: A regional Veterans Healthcare Administration database was used to identify veterans meeting criteria for this retrospective chart review. All patients confirmed to have SCHZ and to have received antiviral therapy between 1998 and 2006 (n = 30) were compared with a control group of demographically matched (HCV genotype, age, race, gender) patients with no history of SCHZ (n = 30). Results: For HCV patients with genotype 1, antiviral completion, end of treatment response (ETR), and sustained viral response (SVR) rates did not significantly differ between groups. For those with genotypes 2 and 3 combined, antiviral therapy completion rates did not significantly differ between groups; however, the SCHZ group was significantly (P < 0.050) more likely to achieve an ETR and an SVR. For all genotypes combined, the SCHZ patients were no more likely than controls to discontinue therapy early for psychiatric symptoms, medical complications, or other adverse events, and groups did not significantly differ in terms of hospitalization rates during antiviral therapy. Conclusion: Our retrospective chart review suggests that patients with SCHZ complete and respond to antiviral therapy for HCV at rates comparable with those without SCHZ. Based on these data, SCHZ should not be considered a contraindication to antiviral therapy for HCV. JF - Schizophrenia Bulletin AU - Huckans, Marilyn AU - Mitchell, Alex AU - Ruimy, Samantha AU - Loftis, Jennifer AU - Hauser, Peter AD - 2 Northwest Hepatitis C Resource Center, marilyn.huckans@va.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 165 EP - 172 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 36 IS - 1 SN - 0586-7614, 0586-7614 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts; Virology & AIDS Abstracts KW - Schizophrenia KW - Databases KW - Mental disorders KW - Data processing KW - Hepatitis C virus KW - Genotypes KW - Hepatitis C KW - Races KW - A 01340:Antibiotics & Antimicrobials KW - N3 11001:Behavioral and Cognitive Neuroscience KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038601046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+Bulletin&rft.atitle=Antiviral+Therapy+Completion+and+Response+Rates+Among+Hepatitis+C+Patients+With+and+Without+Schizophrenia&rft.au=Huckans%2C+Marilyn%3BMitchell%2C+Alex%3BRuimy%2C+Samantha%3BLoftis%2C+Jennifer%3BHauser%2C+Peter&rft.aulast=Huckans&rft.aufirst=Marilyn&rft.date=2010-01-01&rft.volume=36&rft.issue=1&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+Bulletin&rft.issn=05867614&rft_id=info:doi/10.1093%2Fschbul%2Fsbn065 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2013-08-23 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Databases; Mental disorders; Data processing; Hepatitis C; Genotypes; Races; Hepatitis C virus DO - http://dx.doi.org/10.1093/schbul/sbn065 ER - TY - JOUR T1 - Lipopolysaccharide binding protein inhibitory peptide protects against acetaminophen-induced hepatotoxicity AN - 1038592088; 14044434 AB - Acetaminophen (APAP)-induced liver injury remains the main cause of acute liver failure in the United States. Our previous work demonstrated that LPS binding protein (LBP) knockout mice are protected from APAP-induced hepatotoxicity. LBP is known to bind avidly to LPS, facilitating cellular activation. In this study, we sought to specifically inhibit the interaction between LBP and LPS to define the role of this interaction in APAP-induced liver injury. The peptide LBPK95A was able to inhibit LBP-mediated LPS activation of RAW 267.4 cells in a dose-dependent manner in vitro. In vivo, C57Bl/6 mice were treated with either LBPK95A or vehicle control concurrently with the administration of APAP (350 mg/kg). Mice treated with LBPK95A had significantly lower serum aspartate aminotransferase and alanine aminotransferase levels. Morphometric analysis of the liver tissue showed significantly less liver injury in mice treated with LBPK95A. To assess whether the LBPK95A altered glutathione depletion and APAP metabolism, we measured total glutathione levels in the liver after APAP. We found no difference in the glutathione levels and APAP-adduct formation between LBPK95A vs. vehicle control both at baseline and after APAP. In conclusion, our results support the hypothesis that LBP-induced liver injury after APAP is due to its ability to mediate activation by endogenous LPS. Our results suggest that blocking LBP-LPS interactions is a potential therapeutic avenue for the treatment of APAP-induced liver injury. JF - American Journal of Physiology - Gastrointestinal and Liver Physiology AU - Su, G L AU - Hoesel, L M AU - Bayliss, J AU - Hemmila, M R AU - Wang, S C AD - Veterans Administration Ann Arbor Healthcare Systems Y1 - 2010 PY - 2010 DA - 2010 SP - G1319 EP - G1325 PB - The American Physiological Society VL - 299 IS - 6 SN - 1522-1547, 1522-1547 KW - Toxicology Abstracts KW - Acetaminophen KW - Alanine transaminase KW - Aspartate aminotransferase KW - Glutathione KW - Injuries KW - Lipopolysaccharides KW - Liver KW - Liver diseases KW - Metabolism KW - hepatotoxicity KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038592088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology+-+Gastrointestinal+and+Liver+Physiology&rft.atitle=Lipopolysaccharide+binding+protein+inhibitory+peptide+protects+against+acetaminophen-induced+hepatotoxicity&rft.au=Su%2C+G+L%3BHoesel%2C+L+M%3BBayliss%2C+J%3BHemmila%2C+M+R%3BWang%2C+S+C&rft.aulast=Su&rft.aufirst=G&rft.date=2010-01-01&rft.volume=299&rft.issue=6&rft.spage=G1319&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology+-+Gastrointestinal+and+Liver+Physiology&rft.issn=15221547&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Liver diseases; Injuries; Aspartate aminotransferase; Glutathione; Liver; Lipopolysaccharides; Alanine transaminase; Acetaminophen; Metabolism; hepatotoxicity ER - TY - JOUR T1 - Myocardial Stunning Following Combined Modality Combretastatin-Based Chemotherapy: Two Case Reports and Review of the Literature AN - 746296248; 12887803 AB - Myocardial stunning, known as stress cardiomyopathy, broken-heart syndrome, transient left ventricular apical ballooning, and Takotsubo cardiomyopathy, has been reported after many extracardiac stressors, but not following chemotherapy. We report 2 cases with characteristic electrocardiographic and echocardiographic features following combined modality therapy with combretastatin, a vascular-disrupting agent being studied for treatment of anaplastic thyroid cancer. In 1 patient, an ECG performed per protocol 18 hours after drug initiation showed deep, symmetric T-wave inversions in limb leads I and aVL and precordial leads V2 through V6. Echocardiography showed mildly reduced overall left ventricular systolic function with akinesis of the entire apex. The patient had mild elevations of troponin I. Coronary angiography revealed no epicardial coronary artery disease. The electrocardiographic and echocardiographic abnormalities resolved after several weeks. The patient remains stable from a cardiovascular standpoint and has not had a recurrence during follow-up. An electrocardiogram performed per protocol in a second patient showed deep, symmetric T-wave inversions throughout the precordial leads and a prolonged QT interval. Echocardiography showed mildly reduced left ventricular function with hypokinesis of the apical-septal wall. Acute coronary syndrome was ruled out, and both the electrocardiographic and echocardiographic changes resolved at follow-up. Although the patient remained pain-free without recurrence of anginal symptoms during long-term follow-up, the patient developed progressive malignancy and died. JF - Clinical Cardiology (Hoboken) AU - Bhakta, Shyam AU - Flick, Susan M AU - Cooney, Matthey M AU - Greskovich, John F AU - Gilkeson, Robert C AU - Remick, Scot C AU - Ortiz, Jose AD - Harrington-McLaughlin Heart and Vascular Institute, Ireland Cancer Center, and Department of Radiology, University Hospitals-Case Medical Center, Cleveland, Ohio, jose.ortiz@med.va.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - E80 EP - E84 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 32 IS - 12 SN - 0160-9289, 0160-9289 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Heart KW - Chemotherapy KW - Echocardiography KW - Stress KW - EKG KW - Cardiomyopathy KW - Angiography KW - Malignancy KW - Ventricle KW - Limbs KW - Case reports KW - Inversion KW - thyroid cancer KW - Troponin I KW - Heart diseases KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746296248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cardiology+%28Hoboken%29&rft.atitle=Myocardial+Stunning+Following+Combined+Modality+Combretastatin-Based+Chemotherapy%3A+Two+Case+Reports+and+Review+of+the+Literature&rft.au=Bhakta%2C+Shyam%3BFlick%2C+Susan+M%3BCooney%2C+Matthey+M%3BGreskovich%2C+John+F%3BGilkeson%2C+Robert+C%3BRemick%2C+Scot+C%3BOrtiz%2C+Jose&rft.aulast=Bhakta&rft.aufirst=Shyam&rft.date=2009-12-01&rft.volume=32&rft.issue=12&rft.spage=E80&rft.isbn=&rft.btitle=&rft.title=Clinical+Cardiology+%28Hoboken%29&rft.issn=01609289&rft_id=info:doi/10.1002%2Fclc.20685 L2 - http://www3.interscience.wiley.com/journal/123196788/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Heart; Chemotherapy; Echocardiography; Stress; EKG; Cardiomyopathy; Ventricle; Malignancy; Angiography; Limbs; Case reports; Inversion; thyroid cancer; Troponin I; Heart diseases DO - http://dx.doi.org/10.1002/clc.20685 ER - TY - JOUR T1 - Comorbid Depression and Anxiety Symptoms as Predictors of Cardiovascular Events: Results From the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study AN - 746236657; 13225800 AB - Objective: To study the independent and interactive effects of depression and anxiety symptoms as predictors of cardiovascular disease (CVD) events in a sample of women with suspected myocardial ischemia. Symptoms of depression and anxiety overlap strongly and are independent predictors of CVD events. Although these symptoms commonly co-occur in medical patients, little is known about combined effects of depression and anxiety on CVD risk. Method: A total of 489 women completed a baseline protocol including coronary angiogram, CVD risk factor assessment, and questionnaire-based measures of depression and anxiety symptoms, using the Beck Depression Inventory (BDI) and State Trait Anxiety Inventory (STAI), respectively. Participants were followed for a median 5.9 years to track the prevalence of CVD events (stroke, myocardial infarction, heart failure, and CVD-related mortality). We tested the BDI X STAI interaction effect in addition to the BDI and STAI main effects. Results: Seventy-five women (15.3% of sample) experienced a CVD event, of which 18 were deaths attributed to cardiovascular causes. Results using Cox regression indicated a significant BDI x STAI interaction effect in the prediction of CVD events (p = .02) after covariate adjustment. Simple effect analyses indicated that depression scores were significant predictors of CVD events among women with low anxiety scores (hazard ratio [HR] = 2.3 [in standard deviation units]; 95% Confidence Interval [CI] = 1.3-3.9; p = .005) but not among women with higher levels of anxiety (HR = 0.99; 95% CI = 0.70-1.4; p = .95). Conclusion: Among women with suspected myocardial ischemia, the value of depression symptoms for predicting CVD events varied by the severity of comorbid anxiety. These results suggest that the clinical utility of depression measures may be improved by using them in combination with measures of anxiety. JF - Psychosomatic Medicine AU - Rutledge, T AU - Linke, SE AU - Krantz, D S AU - Johnson, B D AU - Bittner, V AU - Eastwood, J-A AU - Eteiba, W AU - Pepine, C J AU - Vaccarino, V AU - Francis, J AU - Vido, DA AU - Merz, CNB AD - Psychology Service 116B, VA San Diego Healthcare System, Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161, USA, Thomas.Rutledge@va.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 958 EP - 964 VL - 71 IS - 9 SN - 0033-3174, 0033-3174 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Inventories KW - Mortality KW - Myocardial ischemia KW - Depression KW - Anxiety KW - Stroke KW - Ischemia KW - Myocardial infarction KW - Standard deviation KW - Risk factors KW - Cardiovascular diseases KW - Heart diseases KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746236657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+Medicine&rft.atitle=Comorbid+Depression+and+Anxiety+Symptoms+as+Predictors+of+Cardiovascular+Events%3A+Results+From+the+NHLBI-Sponsored+Women%27s+Ischemia+Syndrome+Evaluation+%28WISE%29+Study&rft.au=Rutledge%2C+T%3BLinke%2C+SE%3BKrantz%2C+D+S%3BJohnson%2C+B+D%3BBittner%2C+V%3BEastwood%2C+J-A%3BEteiba%2C+W%3BPepine%2C+C+J%3BVaccarino%2C+V%3BFrancis%2C+J%3BVido%2C+DA%3BMerz%2C+CNB&rft.aulast=Rutledge&rft.aufirst=T&rft.date=2009-12-01&rft.volume=71&rft.issue=9&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+Medicine&rft.issn=00333174&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Mortality; Inventories; Myocardial ischemia; Standard deviation; Depression; Anxiety; Risk factors; Stroke; Cardiovascular diseases; Ischemia; Myocardial infarction; Heart diseases ER - TY - JOUR T1 - Reduction of amiodarone pulmonary toxicity in patients treated with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers AN - 746076292; 12507873 AB - Background: Amiodarone (AM) is a widely used anti-arrhythmic medication. Its utility is, however, limited by adverse side effects. The mechanism of amiodarone-induced toxicity (APT) in the lungs is attributed primarily to stimulation of the angiotensin enzyme system leading to lung cell apoptosis and cell death. This mechanism has been demonstrated by in vitro and in vivo experimental animal studies. To date, however, no in vivo human studies have confirmed this mechanism for APT.Purpose: This study was undertaken to determine whether angiotensin converting enzyme inhibitors (ACE-I) or angiotensin receptor blockers (ARB) offer a protective effect against APT in humans. Demonstration of a protective effect of an ACE-I or ARB would suggest that stimulation of the angiotensin enzyme system may be a key process in APT.Design: An 8-year retrospective analysis of all patients on AM therapy at the James H. Quillen Veterans Affairs Medical Center was undertaken.Results: A total of 1000 patients on AM were identified. One-hundred-and-seventeen were excluded from the study. Five-hundred-and-twenty-four patients were simultaneously on an ACE-I or ARB. The remaining 359 patients were not. Pulmonary toxicity attributed to AM was identified in five and 14 patients with and without concomitant ACE-I or ARB therapy, respectively. The APT rate for the entire patient sample was 2.2%. APT occurred in 1% of patients on an ACE-I or ARB and in 3.9% of patients not taking an ACE-I or ARB. This observed difference in percentage of APT was statistically significant.Conclusion: The concomitant use of ACE-I or ARB in patients taking AM appears to offer a protective effect against APT. This observation suggests that the stimulation of the angiotensin enzyme system may play an important role in APT in humans. JF - Therapeutic Advances in Respiratory Disease AU - Kosseifi, Semaan G AU - Halawa, Ahmed AU - Bailey, Beth AU - Micklewright, Melinda AU - Roy, Thomas M AU - Byrd, Ryland P AD - Division of Pulmonary Diseases and Critical Care Medicine, East Tennessee, State University, Johnson City, TN, USA, Ryland.Byrd@med.va.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 289 EP - 294 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 3 IS - 6 SN - 1753-4658, 1753-4658 KW - Toxicology Abstracts KW - amiodarone KW - angiotensin-converting enzyme inhibitors KW - angiotensin receptor blockers KW - pulmonary toxicity KW - Peptidyl-dipeptidase A KW - Apoptosis KW - Angiotensin-converting enzyme inhibitors KW - Lung KW - Angiotensin receptors KW - Enzymes KW - Toxicity KW - Angiotensin KW - Amiodarone KW - Side effects KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746076292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+Advances+in+Respiratory+Disease&rft.atitle=Reduction+of+amiodarone+pulmonary+toxicity+in+patients+treated+with+angiotensin-converting+enzyme+inhibitors+and+angiotensin+receptor+blockers&rft.au=Kosseifi%2C+Semaan+G%3BHalawa%2C+Ahmed%3BBailey%2C+Beth%3BMicklewright%2C+Melinda%3BRoy%2C+Thomas+M%3BByrd%2C+Ryland+P&rft.aulast=Kosseifi&rft.aufirst=Semaan&rft.date=2009-12-01&rft.volume=3&rft.issue=6&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Therapeutic+Advances+in+Respiratory+Disease&rft.issn=17534658&rft_id=info:doi/10.1177%2F1753465809348015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Peptidyl-dipeptidase A; Apoptosis; Angiotensin-converting enzyme inhibitors; Angiotensin receptors; Lung; Enzymes; Toxicity; Angiotensin; Side effects; Amiodarone DO - http://dx.doi.org/10.1177/1753465809348015 ER - TY - JOUR T1 - Reducing Violence Against Nurses: The Violence Prevention Community Meeting AN - 742722769; 201017049 AB - Research was undertaken to validate the efficacy of a new, nurse-led treatment, the Violence Prevention Community Meeting (VPCM), for reducing patient violence on an acute-care inpatient psychiatry unit. Nursing staff members carried event counters and recorded verbal and physical violence as it occurred over the 20-week study. Significant decreases in patient violence were found across day, evening, and night shifts for pre-treatment vs. treatment and pre-treatment vs. post-treatment comparisons. For the day shift, when twice-weekly VPCM treatment took place, violent incidents decreased 89% from pre-treatment to treatment and 57% from pre-treatment to post-treatment. Adapted from the source document. JF - Issues in Mental Health Nursing AU - Lanza, Marilyn L AU - Rierdan, Jill AU - Forester, Linda AU - Zeiss, Robert A AD - Edith Nourse Rogers Memorial Veterans Hospital, Bedford, Massachusetts, USA marilyn.lanza@va.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 745 EP - 750 PB - Informa Healthcare, Taylor & Francis, New York NY VL - 30 IS - 12 SN - 0161-2840, 0161-2840 KW - Prevention KW - Nursing KW - Acute services KW - Community meetings KW - Violence KW - Nurse led services KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742722769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Issues+in+Mental+Health+Nursing&rft.atitle=Reducing+Violence+Against+Nurses%3A+The+Violence+Prevention+Community+Meeting&rft.au=Lanza%2C+Marilyn+L%3BRierdan%2C+Jill%3BForester%2C+Linda%3BZeiss%2C+Robert+A&rft.aulast=Lanza&rft.aufirst=Marilyn&rft.date=2009-12-01&rft.volume=30&rft.issue=12&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Issues+in+Mental+Health+Nursing&rft.issn=01612840&rft_id=info:doi/10.3109%2F01612840903177472 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - CODEN - IHNUDT N1 - SubjectsTermNotLitGenreText - Violence; Prevention; Community meetings; Acute services; Nursing; Nurse led services DO - http://dx.doi.org/10.3109/01612840903177472 ER - TY - JOUR T1 - Rationale and design of the dal-OUTCOMES trial: efficacy and safety of dalcetrapib in patients with recent acute coronary syndrome. AN - 734169915; 19958854 AB - Despite contemporary therapies for acute coronary syndrome (ACS), morbidity and mortality remain high. Low levels of high-density lipoprotein (HDL) cholesterol are common among patients with ACS and may contribute to ongoing risk. Strategies that raise levels of HDL cholesterol, such as inhibition of cholesterol ester transfer protein (CETP), might reduce risk after ACS. Dal-OUTCOMES is a multicenter, randomized, double-blind, placebo-controlled trial designed to test the hypothesis that CETP inhibition with dalcetrapib reduces cardiovascular morbidity and mortality in patients with recent ACS. The study will randomize approximately 15,600 patients to receive daily doses of dalcetrapib 600 mg or matching placebo, beginning 4 to 12 weeks after an index ACS event. There are no prespecified boundaries for HDL cholesterol levels at entry. Other elements of care, including management of low-density lipoprotein cholesterol, are to follow best evidence-based practice. The primary efficacy measure is time to first occurrence of coronary heart disease death, nonfatal acute myocardial infarction, unstable angina requiring hospital admission, resuscitated cardiac arrest, or atherothrombotic stroke. The trial will continue until 1,600 primary end point events have occurred, all evaluable subjects have been followed for at least 2 years, and 80% of evaluable subjects have been followed for at least 2.5 years. Dal-OUTCOMES will determine whether CETP inhibition with dalcetrapib, added to current evidence-based care, reduces cardiovascular morbidity and mortality after ACS. JF - American heart journal AU - Schwartz, Gregory G AU - Olsson, Anders G AU - Ballantyne, Christie M AU - Barter, Phillip J AU - Holme, Ingar M AU - Kallend, David AU - Leiter, Lawrence A AU - Leitersdorf, Eran AU - McMurray, John J V AU - Shah, Prediman K AU - Tardif, Jean-Claude AU - Chaitman, Bernard R AU - Duttlinger-Maddux, Regina AU - Mathieson, John AU - dal-OUTCOMES Committees and Investigators AD - VA Medical Center and University of Colorado, Denver, CO 80220, USA. gregory.schwartz@va.gov ; dal-OUTCOMES Committees and Investigators Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 896 EP - 901.e3 VL - 158 IS - 6 KW - Anticholesteremic Agents KW - 0 KW - Sulfhydryl Compounds KW - dalcetrapib KW - 3D050LIQ3H KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Sulfhydryl Compounds -- adverse effects KW - Anticholesteremic Agents -- therapeutic use KW - Anticholesteremic Agents -- adverse effects KW - Acute Coronary Syndrome -- drug therapy KW - Research Design KW - Sulfhydryl Compounds -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734169915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Rationale+and+design+of+the+dal-OUTCOMES+trial%3A+efficacy+and+safety+of+dalcetrapib+in+patients+with+recent+acute+coronary+syndrome.&rft.au=Schwartz%2C+Gregory+G%3BOlsson%2C+Anders+G%3BBallantyne%2C+Christie+M%3BBarter%2C+Phillip+J%3BHolme%2C+Ingar+M%3BKallend%2C+David%3BLeiter%2C+Lawrence+A%3BLeitersdorf%2C+Eran%3BMcMurray%2C+John+J+V%3BShah%2C+Prediman+K%3BTardif%2C+Jean-Claude%3BChaitman%2C+Bernard+R%3BDuttlinger-Maddux%2C+Regina%3BMathieson%2C+John%3Bdal-OUTCOMES+Committees+and+Investigators&rft.aulast=Schwartz&rft.aufirst=Gregory&rft.date=2009-12-01&rft.volume=158&rft.issue=6&rft.spage=896&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=1097-6744&rft_id=info:doi/10.1016%2Fj.ahj.2009.09.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-06 N1 - Date created - 2009-12-04 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00658515; ClinicalTrials.gov N1 - SuppNotes - Comment In: Curr Diab Rep. 2011 Feb;11(1):4-6 [21069482] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ahj.2009.09.017 ER - TY - JOUR T1 - Developing and validating process measures of health care quality: an application to alcohol use disorder treatment. AN - 733590930; 19786908 AB - Health care process quality measures usually are designed by expert panels attempting to synthesize nuanced clinical evidence and subsequently operationalized using administrative data. Many quality measures are then adopted without directly validating their presumed links with outcomes. Later efforts to validate process measures often yield negative results, leaving policy makers without a defensible means of measuring quality. This article presents an alternative strategy for developing and validating process quality measures. The development of an alcohol use disorder (AUD) treatment quality measure is used as an example. An expert panel generated a range of candidate process quality measures of AUD treatment derivable from administrative data that were then tested to determine which had the strongest associations with facility- and patient-level outcomes. Outcome and process data were from 2701 US Veterans Health Administration patients starting a new episode of care at 54 VA facilities. Several of the candidate process-of-care quality measures predicted facility- and patient-level outcomes. Having at least 3 visits during the first month of specialty AUD treatment was correlated with improvement on the Addiction Severity Index Alcohol composite at the facility level, r = 0.41 (95% Confidence Interval 0.16-0.61), and at the patient level, r = 0.07 (CI: 0.03-0.11). These "prevalidated" quality measures can now be judged for the extent they map onto the extant clinical literature and other design requirements. The development and validation strategy we describe should aid in efficiently producing quality measures in other areas of health care. JF - Medical care AU - Harris, Alex H S AU - Kivlahan, Daniel R AU - Bowe, Thomas AU - Finney, John W AU - Humphreys, Keith AD - Center for Health Care Evaluation, VA Palo Alto Health Care System, Stanford University School of Medicine, Menlo Park, CA 94025, USA. alexander.harris2@va.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1244 EP - 1250 VL - 47 IS - 12 KW - Index Medicus KW - United States KW - Reproducibility of Results KW - Humans KW - Quality of Health Care -- organization & administration KW - United States Department of Veterans Affairs -- organization & administration KW - Process Assessment (Health Care) -- organization & administration KW - Quality Indicators, Health Care KW - Alcoholism -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733590930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Developing+and+validating+process+measures+of+health+care+quality%3A+an+application+to+alcohol+use+disorder+treatment.&rft.au=Harris%2C+Alex+H+S%3BKivlahan%2C+Daniel+R%3BBowe%2C+Thomas%3BFinney%2C+John+W%3BHumphreys%2C+Keith&rft.aulast=Harris&rft.aufirst=Alex+H&rft.date=2009-12-01&rft.volume=47&rft.issue=12&rft.spage=1244&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=1537-1948&rft_id=info:doi/10.1097%2FMLR.0b013e3181b58882 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-14 N1 - Date created - 2009-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MLR.0b013e3181b58882 ER - TY - JOUR T1 - Braking the Bandwagon: Scrutinizing the Science and Politics of Empirically Supported Therapies AN - 57341577; 201002840 AB - Proponents of empirically supported therapies (ESTs) argue that because manualized ESTs have demonstrated efficacy in treating a range of psychological disorders, they should be the treatments of choice. In this article, the author uses a hypothetical treatment for obesity to highlight numerous flaws in EST logic and argues for common factors as a more clinically relevant but empirically challenging approach. The author then explores how political variables may be contributing to the expansion of EST and the resulting restriction of practitioner autonomy. Last, the author argues that EST is best viewed as 1 component of a more comprehensive evidence-based practice framework. The author concludes with some cautionary statements about the perils of equating the EST paradigm with the scientist-practitioner ideal. Adapted from the source document. JF - The Journal of Psychology AU - Hagemoser, Steven D AD - VA Central Iowa Health Care System, 3600 30th Street, Building 6M, Room 138, Des Moines, IA 50310, USA E-mail: steven.hagemoser2@va.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 601 EP - 614 PB - Heldref Publications, Washington DC VL - 143 IS - 6 SN - 0022-3980, 0022-3980 KW - common factors, empirically supported therapies, evidence-based practice, politics KW - Obesity KW - Efficacy KW - Politics KW - Psychological disorders KW - Autonomy KW - Models KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57341577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Psychology&rft.atitle=Braking+the+Bandwagon%3A+Scrutinizing+the+Science+and+Politics+of+Empirically+Supported+Therapies&rft.au=Hagemoser%2C+Steven+D&rft.aulast=Hagemoser&rft.aufirst=Steven&rft.date=2009-12-01&rft.volume=143&rft.issue=6&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Psychology&rft.issn=00223980&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-02-03 N1 - Last updated - 2016-09-27 N1 - CODEN - JOPSAM N1 - SubjectsTermNotLitGenreText - Politics; Obesity; Autonomy; Psychological disorders; Efficacy; Models ER - TY - JOUR T1 - Consultation as a Means of Veteran Suicide Prevention AN - 57339246; 201002834 AB - The development and implementation of a suicide consultation service being run by an interdisciplinary team in a metropolitan Veteran's Administration (VA) medical center is described. This service is grounded in a collaborative theoretical framework. An overview of the consultation process and theoretical and empirical literature to support the framework used by the service are provided. Some of the interventions commonly recommended to referring clinicians to reduce client suicide risk are reviewed. Although there are many challenges to running a service such as this, the authors conclude that the model presented is flexible enough to be applied in a variety of settings. [Copyright Elsevier B.V.] JF - Professional Psychology: Research and Practice AU - Gutierrez, Peter M AU - Brenner, Lisa A AU - Olson-Madden, Jennifer H AU - Breshears, Ryan E AU - Homaifar, Beeta Y AU - Betthauser, Lisa M AU - Staves, Pamela AU - Adler, Lawrence E AD - Denver VA Medical Center e-mail:peter.gutierrez@va.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 586 EP - 592 PB - American Psychological Association, Washington DC VL - 40 IS - 6 SN - 0735-7028, 0735-7028 KW - suicide veterans consultation assessment collaboration KW - Interdisciplinary team work KW - Interventions KW - Consultation KW - Suicide KW - Risk reduction KW - Preventive programmes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57339246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Psychology%3A+Research+and+Practice&rft.atitle=Consultation+as+a+Means+of+Veteran+Suicide+Prevention&rft.au=Gutierrez%2C+Peter+M%3BBrenner%2C+Lisa+A%3BOlson-Madden%2C+Jennifer+H%3BBreshears%2C+Ryan+E%3BHomaifar%2C+Beeta+Y%3BBetthauser%2C+Lisa+M%3BStaves%2C+Pamela%3BAdler%2C+Lawrence+E&rft.aulast=Gutierrez&rft.aufirst=Peter&rft.date=2009-12-01&rft.volume=40&rft.issue=6&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=Professional+Psychology%3A+Research+and+Practice&rft.issn=07357028&rft_id=info:doi/10.1037%2Fa0016497 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Consultation; Suicide; Preventive programmes; Interventions; Interdisciplinary team work; Risk reduction DO - http://dx.doi.org/10.1037/a0016497 ER - TY - JOUR T1 - Adapting the Multifamily Group Model to the Veterans Affairs System: The REACH Program AN - 57313944; 201003423 AB - The Oklahoma City Veterans Affairs (VA) Medical Center modified an evidence-based model of family psychoeducation (the multifamily group model; McFarlane, 2002) and implemented it for the first time in a VA setting and with veterans living with posttraumatic stress disorder (PTSD). Named the REACH Program (Reaching out to Educate and Assist Caring, Healthy Families), the 3-phase program begins with 4 weekly 'joining sessions' with the individual veteran and his/her family focused on rapport building, assessment, and goal setting. Phase II consists of 6 weekly diagnosis-specific educational/support sessions for cohorts of 4 to 6 veterans and their families. In Phase III, veterans/families attend 6 monthly multifamily groups to support the maintenance of gains. This article describes the rationale for modifying the original Multifamily Group Program (MFG) for a unique setting (the VA) and the needs of families of veterans in a new diagnostic group (PTSD). The changes to the MFG curriculum are specifically described, and details of the new REACH intervention are explained. Attendance, retention, and satisfaction data for 2 diagnostic cohorts, PTSD and affective disorders, are also presented. [Copyright Elsevier B.V.] JF - Professional Psychology: Research and Practice AU - Sherman, Michelle D AU - Fischer, Ellen P AU - Sorocco, Kristen AU - McFarlane, William R AD - Oklahoma City Veterans Affairs Medical Center e-mail:michelle.sherman@va.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 593 EP - 600 PB - American Psychological Association, Washington DC VL - 40 IS - 6 SN - 0735-7028, 0735-7028 KW - family psychoeducation PTSD affective disorders family therapy multifamily group KW - Evidence based KW - Veterans KW - Posttraumatic stress disorder KW - Caring KW - Psychoeducational treatment KW - First time KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57313944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Psychology%3A+Research+and+Practice&rft.atitle=Adapting+the+Multifamily+Group+Model+to+the+Veterans+Affairs+System%3A+The+REACH+Program&rft.au=Sherman%2C+Michelle+D%3BFischer%2C+Ellen+P%3BSorocco%2C+Kristen%3BMcFarlane%2C+William+R&rft.aulast=Sherman&rft.aufirst=Michelle&rft.date=2009-12-01&rft.volume=40&rft.issue=6&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Professional+Psychology%3A+Research+and+Practice&rft.issn=07357028&rft_id=info:doi/10.1037%2Fa0016333 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Veterans; Posttraumatic stress disorder; First time; Psychoeducational treatment; Evidence based; Caring DO - http://dx.doi.org/10.1037/a0016333 ER - TY - JOUR T1 - Self-reported screening of nephrologists for chronic kidney disease: a nationwide survey AN - 21311254; 11907205 AB - Background: The incidence of chronic kidney disease (CKD) is increasing, with major health and economic implications. World Kidney Day was established to increase the general public's awareness of CKD. The purpose of this report was to document the self-awareness of CKD by nephrologists practicing in one country, Nigeria. Methods: Self-administered questionnaires addressing self-awareness about CKD were distributed to nephrologists attending a meeting of the Nigerian Association of Nephrology. Results: Twenty-eight (35.4%) of the respondents admitted to being at risk for CKD; 93.7% reported having urinalysis done in the past, but only 50.6% had done it within the last 12months. Similarly, 74.7% had at least had a serum creatinine measurement. Only 12.7% had ever had their glomerular filtration rate (GFR) estimated. Conclusion: Self-screening for CKD among Nigerian nephrologists is suboptimal. This self-neglect may translate into poor CKD screening practices for their patients. JF - International Urology and Nephrology AU - Agaba, Emmanuel I AU - Mamven, Manmak H AU - Agaba, Patricia A AU - Tzamaloukas, Antonios Helias AD - Renal Section (111C), Department of Medicine, Raymond G. Murphy Veterans Affairs Health Care System, Robert G. Murphy VA Medical Center, University of New Mexico School of Medicine, 1501 San Pedro, SE, Albuquerque, NM, 87108, USA, antonios.tzamaloukas@med.va.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 973 EP - 976 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 41 IS - 4 SN - 0301-1623, 0301-1623 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Inventories KW - Creatinine KW - Economics KW - Kidney diseases KW - Glomerular filtration rate KW - Urinalysis KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21311254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Urology+and+Nephrology&rft.atitle=Self-reported+screening+of+nephrologists+for+chronic+kidney+disease%3A+a+nationwide+survey&rft.au=Agaba%2C+Emmanuel+I%3BMamven%2C+Manmak+H%3BAgaba%2C+Patricia+A%3BTzamaloukas%2C+Antonios+Helias&rft.aulast=Agaba&rft.aufirst=Emmanuel&rft.date=2009-12-01&rft.volume=41&rft.issue=4&rft.spage=973&rft.isbn=&rft.btitle=&rft.title=International+Urology+and+Nephrology&rft.issn=03011623&rft_id=info:doi/10.1007%2Fs11255-009-9538-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Inventories; Creatinine; Economics; Kidney diseases; Urinalysis; Glomerular filtration rate DO - http://dx.doi.org/10.1007/s11255-009-9538-9 ER - TY - JOUR T1 - Evidence-based review of probiotics for antibiotic-associated diarrhea and Clostridium difficile infections AN - 21253033; 11789191 AB - Probiotics are living microbes taken to confer a health benefit on the host. Although probiotics have a long history of use in Europe and Asia and have been on the U.S. market for over 14 years, there is still confusion about how to effectively use them. The use of probiotics for the prevention of antibiotic-associated diarrhea (AAD) and the treatment of Clostridium difficile infections (CDI) has been tested in randomized controlled clinical trials. This paper will review the evidence supporting probiotic therapy for these two diseases and also review the advantages and disadvantages of probiotics. The advantages of probiotic therapy include multiple mechanisms of action against pathogens, the ability to interact with the host's natural defense systems, survival to the target organ and a good risk to benefit ratio. Disadvantages of probiotics include lack of standardization for clinical trial designs, variations in regulatory standards, poor quality control for some products and infrequent serious adverse reactions. Overall, probiotics offer a promising strategy for the prevention and treatment for AAD and CDI JF - Anaerobe AU - McFarland, Lynne V Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 274 EP - 280 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 15 IS - 6 SN - 1075-9964, 1075-9964 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Standardization KW - Diarrhea KW - Reviews KW - Quality control KW - probiotics KW - Survival KW - Clostridium difficile KW - Pathogens KW - Infection KW - Clinical trials KW - Side effects KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21253033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Evidence-based+review+of+probiotics+for+antibiotic-associated+diarrhea+and+Clostridium+difficile+infections&rft.au=McFarland%2C+Lynne+V&rft.aulast=McFarland&rft.aufirst=Lynne&rft.date=2009-12-01&rft.volume=15&rft.issue=6&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=10759964&rft_id=info:doi/10.1016%2Fj.anaerobe.2009.09.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Standardization; Diarrhea; Quality control; Reviews; probiotics; Survival; Pathogens; Infection; Clinical trials; Side effects; Clostridium difficile DO - http://dx.doi.org/10.1016/j.anaerobe.2009.09.002 ER - TY - JOUR T1 - Distribution of Clostridium difficile strains from a North American, European and Australian trial of treatment for C. difficile infections: 2005-2007 AN - 21234975; 11789180 AB - Clostridium difficile is a widely distributed pathogen with multiple strain types as determined by restriction endonuclease analysis (REA) and by PCR ribotyping, two well-characterized typing systems. In this study, REA typing was performed on 894 C. difficile isolates from patients enrolled from 16 countries on three continents in two large, recently conducted clinical treatment trials of C. difficile infection. REA group BI (Ribotype 027) isolates were the most common strains identified and were widely distributed throughout North America, but restricted to three of thirteen countries in Europe. REA group J (Ribotype 001) isolates were the most common strains identified in Europe and non-specific REA groups (historically less frequent) were the most common strains identified in Australia. REA groups BI, J, G and CF correlated with specific PCR ribotypes whereas more than one ribotype was found within REA groups Y, BK, and K. International surveillance of C. difficile strains is important to document the changing epidemiology of this enteric pathogen that continues to cause healthcare facility outbreaks and sporadic infections in other settings. JF - Anaerobe AU - Cheknis, Adam K AU - Sambol, Susan P AU - Davidson, David M AU - Nagaro, Kristin J AU - Mancini, Maria C AU - Hidalgo-Arroyo, GAida AU - Brazier, Jon S AU - Johnson, Stuart AU - Gerding, Dale N AD - Research Service, Hines VA Hospital, Hines, IL 60141-3030, USA, dale.gerding2@va.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 230 EP - 233 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 15 IS - 6 SN - 1075-9964, 1075-9964 KW - Microbiology Abstracts B: Bacteriology KW - Ribotyping KW - Typing KW - Epidemiology KW - Polymerase chain reaction KW - Clostridium difficile KW - Pathogens KW - Infection KW - Endonuclease KW - Clinical trials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21234975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Distribution+of+Clostridium+difficile+strains+from+a+North+American%2C+European+and+Australian+trial+of+treatment+for+C.+difficile+infections%3A+2005-2007&rft.au=Cheknis%2C+Adam+K%3BSambol%2C+Susan+P%3BDavidson%2C+David+M%3BNagaro%2C+Kristin+J%3BMancini%2C+Maria+C%3BHidalgo-Arroyo%2C+GAida%3BBrazier%2C+Jon+S%3BJohnson%2C+Stuart%3BGerding%2C+Dale+N&rft.aulast=Cheknis&rft.aufirst=Adam&rft.date=2009-12-01&rft.volume=15&rft.issue=6&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=10759964&rft_id=info:doi/10.1016%2Fj.anaerobe.2009.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Ribotyping; Typing; Epidemiology; Polymerase chain reaction; Pathogens; Endonuclease; Infection; Clinical trials; Clostridium difficile DO - http://dx.doi.org/10.1016/j.anaerobe.2009.09.001 ER - TY - JOUR T1 - Clinical Case Registries: Simultaneous Local and National Disease Registries for Population Quality Management AN - 21184484; 11268881 AB - The Department of Veterans Affairs (VA) has a system-wide, patient-centric electronic medical record system (EMR) within which the authors developed the Clinical Case Registries (CCR) to support population-centric delivery and evaluation of VA medical care. To date, the authors have applied the CCR to populations with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Local components use diagnosis codes and laboratory test results to identify patients who may have HIV or HCV and support queries on local care delivery with customizable reports. For each patient in a local registry, key EMR data are transferred via HL7 messaging to a single national registry. From 128 local registry systems, over 60,000 and 320,000 veterans in VA care have been identified as having HIV and HCV, respectively, and entered in the national database. Local and national reports covering demographics, resource usage, quality of care metrics and medication safety issues have been generated. JF - Journal of the American Medical Informatics Association AU - Backus, Lisa I AU - Gavrilov, Sergey AU - Loomis, Timothy P AU - Halloran, James P AU - Phillips, Barbara R AU - Belperio, Pamela S AU - Mole, Larry A AD - Center for Quality Management in Public Health, Palo Alto HCS, Palo Alto, CA, lisa.backus@va.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 775 EP - 783 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Bethesda MD 20814 USA VL - 16 IS - 6 SN - 1067-5027, 1067-5027 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Demography KW - Databases KW - Data processing KW - Hepatitis C virus KW - Human immunodeficiency virus KW - Informatics KW - electronic medical records KW - V 22360:AIDS and HIV KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21184484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Clinical+Case+Registries%3A+Simultaneous+Local+and+National+Disease+Registries+for+Population+Quality+Management&rft.au=Backus%2C+Lisa+I%3BGavrilov%2C+Sergey%3BLoomis%2C+Timothy+P%3BHalloran%2C+James+P%3BPhillips%2C+Barbara+R%3BBelperio%2C+Pamela+S%3BMole%2C+Larry+A&rft.aulast=Backus&rft.aufirst=Lisa&rft.date=2009-12-01&rft.volume=16&rft.issue=6&rft.spage=775&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/10.1197%2Fjamia.M3203 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Demography; Databases; Data processing; Informatics; electronic medical records; Hepatitis C virus; Human immunodeficiency virus DO - http://dx.doi.org/10.1197/jamia.M3203 ER - TY - JOUR T1 - Multiple Perspectives on Assault: The 360-Degree Interview AN - 20663139; 9419930 AB - Workplace violence is common in health care settings. The authors review various models of this violence that have developed over time. From a linear model, understanding progressed to an interactional and then to a contextual model of assault that examines interactions of the aggressor, victim, and the environment. To date, there has not been a satisfactory research methodology to explore the complexities of the contextual model. This article proposes the 360-degree evaluation as an appropriate methodology for examination of multiple perspectives on assault. The 360-degree model allows comparison of perspectives of the assailant, victim, victim's peers, and victim's supervisor. J Am Psychiatr Nurses Assoc, 2009; 14(6), 413-420. JF - Journal of the American Psychiatric Nurses Association AU - Lanza, Marilyn Lewis AU - Zeiss, Robert A AU - Rierdan, Jill AD - Nurse Researcher, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, Robert.Zeiss@va.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 413 EP - 420 PB - Sage Publications Ltd., 6 Bonhill St. VL - 14 IS - 6 SN - 1078-3903, 1078-3903 KW - Health & Safety Science Abstracts KW - workplace violence KW - assault KW - health care violence KW - 360-degree evaluation KW - Health care KW - Reviews KW - Occupational safety KW - nursing KW - Violence KW - Working conditions KW - Medical personnel KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20663139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Psychiatric+Nurses+Association&rft.atitle=Multiple+Perspectives+on+Assault%3A+The+360-Degree+Interview&rft.au=Lanza%2C+Marilyn+Lewis%3BZeiss%2C+Robert+A%3BRierdan%2C+Jill&rft.aulast=Lanza&rft.aufirst=Marilyn&rft.date=2009-12-01&rft.volume=14&rft.issue=6&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Psychiatric+Nurses+Association&rft.issn=10783903&rft_id=info:doi/10.1177%2F1078390308327039 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Health care; Reviews; Occupational safety; Violence; nursing; Medical personnel; Working conditions DO - http://dx.doi.org/10.1177/1078390308327039 ER - TY - CPAPER T1 - The role of albumin in CD14-independent activation of MD-2/TLR4 by endotoxin T2 - 38th Autumn Immunology Conference (AIC 2009) AN - 42219304; 5593785 JF - 38th Autumn Immunology Conference (AIC 2009) AU - Esparza, Greg AU - Weiss, Jerrold AU - Zhang, De-Sheng AU - Teghanemt, Athmane AU - Gioannini, Theresa Y1 - 2009/11/20/ PY - 2009 DA - 2009 Nov 20 KW - Endotoxins KW - Albumin KW - TLR4 protein KW - Toll-like receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42219304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=38th+Autumn+Immunology+Conference+%28AIC+2009%29&rft.atitle=The+role+of+albumin+in+CD14-independent+activation+of+MD-2%2FTLR4+by+endotoxin&rft.au=Esparza%2C+Greg%3BWeiss%2C+Jerrold%3BZhang%2C+De-Sheng%3BTeghanemt%2C+Athmane%3BGioannini%2C+Theresa&rft.aulast=Esparza&rft.aufirst=Greg&rft.date=2009-11-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=38th+Autumn+Immunology+Conference+%28AIC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.flip-programs.com/AIC/2009_Program/files/aic2009booklet.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Emergence of bla sub(KPC)-containing Klebsiella pneumoniae in a long-term acute care hospital: a new challenge to our healthcare system AN - 807269142; 13761768 AB - Objectives To characterize isolates of Klebsiella pneumoniae producing KPC carbapenemase (KPC-Kp) associated with an outbreak in a long-term acute care hospital (LTACH) in South Florida. Methods During 21 March to 20 April 2008, 241 K. pneumoniae isolates detected at Integrated Regional Laboratories (Ft. Lauderdale, FL) for which the ertapenem MICs were .4 mg/L were studied. PCR, cloning and sequence analysis were used to detect bla sub(KPC) and to characterize the b-lactamase and outer membrane proteins (Omps). The expression level of KPC enzymes was studied by immunoblotting. Genetic relatedness of isolates was investigated with rep-PCR and PFGE. Clinical records of patients were investigated. Results Seven KPC-Kp strains were isolated from different patients located at a single LTACH, with a further three isolates being recovered from patients at different hospitals. All KPC-Kp isolates in patients from the LTACH and from one hospital patient were genetically related and shared PFGE patterns that clustered with known sequence type (ST) 258 strains. These strains were highly resistant to carbapenems (MICs.32 mg/L) due to an increased level of KPC expression and loss of Omps. Rectal colonization was documented in all LTACH patients with KPC-Kp isolates. Treatment failures were common (crude mortality rate of 69%). Active surveillance and enhanced infection control practices terminated the KPC-Kp outbreak. Conclusions The detection of KPC-Kp in an LTACH represents a serious infection control and therapeutic challenge in a new clinical setting. The speed at which the epidemic of KPC-Kp is spreading in our healthcare system mandates urgent action. JF - Journal of Antimicrobial Chemotherapy AU - Endimiani, Andrea AU - DePasquale, John M AU - Forero, Sandra AU - Perez, Federico AU - Hujer, Andrea M AU - Roberts-Pollack, Daneshia AU - Fiorella, Paul D AU - Pickens, Nancy AU - Kitchel, Brandon AU - Casiano-Colon, Aida E AU - Tenover, Fred C AU - Bonomo, Robert A AD - 5 Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30333, USA, robert.bonomo@med.va.gov robert.bonomo@med.va.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 1102 EP - 1110 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 64 IS - 5 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Immunoblotting KW - Mortality KW - Epidemics KW - Rectum KW - Spreading KW - outer membrane proteins KW - beta -Lactamase KW - ertapenem KW - Enzymes KW - Carbapenems KW - carbapenemase KW - Infection KW - Minimum inhibitory concentration KW - Colonization KW - Polymerase chain reaction KW - b-Lactamase KW - Klebsiella pneumoniae KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807269142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Emergence+of+bla+sub%28KPC%29-containing+Klebsiella+pneumoniae+in+a+long-term+acute+care+hospital%3A+a+new+challenge+to+our+healthcare+system&rft.au=Endimiani%2C+Andrea%3BDePasquale%2C+John+M%3BForero%2C+Sandra%3BPerez%2C+Federico%3BHujer%2C+Andrea+M%3BRoberts-Pollack%2C+Daneshia%3BFiorella%2C+Paul+D%3BPickens%2C+Nancy%3BKitchel%2C+Brandon%3BCasiano-Colon%2C+Aida+E%3BTenover%2C+Fred+C%3BBonomo%2C+Robert+A&rft.aulast=Endimiani&rft.aufirst=Andrea&rft.date=2009-11-01&rft.volume=64&rft.issue=5&rft.spage=1102&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkp327 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; Immunoblotting; beta -Lactamase; outer membrane proteins; Spreading; Rectum; Epidemics; ertapenem; Carbapenems; Enzymes; carbapenemase; Infection; Minimum inhibitory concentration; Colonization; Polymerase chain reaction; b-Lactamase; Hospitals; Klebsiella pneumoniae DO - http://dx.doi.org/10.1093/jac/dkp327 ER - TY - JOUR T1 - Effect of Rotator Cuff Muscle Imbalance on Forceful Internal Impingement and Peel-Back of the Superior Labrum. A Cadaveric Study AN - 746273151; 12609134 AB - Background: Throwing athletes with shoulder pain have been shown to have decreased rotator cuff muscle strength. Shoulder internal impingement and labral peel-back mechanism, as may occur during the late cocking phase of throwing motion, are thought to cause rotator cuff injury and type II superior labrum anterior and posterior lesions. Therefore, the objective of this study was to assess the effect of rotator cuff muscle force on internal impingement and the peel-back of the superior labrum by quantifying maximum external rotation, glenohumeral contact pressure, and position of the cuff insertion relative to the glenoid.Hypothesis: A change in rotator cuff muscle force will lead to increased external rotation, glenohumeral contact pressure, and overlap of the cuff insertion relative to the glenoid.Study Design: Controlled laboratory study.Methods: Eight fresh-frozen cadaveric shoulders were tested at the simulated late cocking position. Glenohumeral contact pressure, location of the cuff insertion relative to the glenoid, and maximum humeral external rotation angle were measured. The forces of the supraspinatus, subscapularis, and infraspinatus muscles were determined based on published clinical electromyographic data. To assess the effect of cuff muscle imbalance, each muscle force was varied. Horizontal abduction positions of 20, 30, and 40 with respect to the scapular plane were tested.Results: Decreased subscapularis strength resulted in a significant increase in maximum external rotation (P < .001) and increased glenohumeral contact pressure (P < .01). The cuff insertion overlapped the edge of the glenoid at 30 and 40 of horizontal abduction for all muscle loading conditions.Conclusion: Decreased subscapularis muscle strength in the position simulating the late cocking phase of throwing motion results in increased maximum external rotation and also increased glenohumeral contact pressure.Clinical Relevance: Athletes with decreased subscapularis muscle strength, such as fatigue with repetitive throwing, may be more susceptible to rotator cuff tears and type II superior labrum anterior and posterior lesions. Subscapularis muscle strengthening exercises may be beneficial for preventing these injuries. JF - American Journal of Sports Medicine AU - Mihata, Teruhisa AU - Gates, Jeffrey AU - McGarry, Michelle H AU - Lee, Jason AU - Kinoshita, Mitsuo AU - Lee, Thay Q AD - Orthopaedic Biomechanics Laboratory, Long Beach VA Healthcare System and University of California, Irvine, California, Department of Orthopedic Surgery, Shoulder & Elbow Biomechanics Laboratory, Osaka Medical College, Japan, tqlee@med.va.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 2222 EP - 2227 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 37 IS - 11 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Throwing KW - Strength KW - Muscles KW - Rotator cuff KW - Stress KW - Shoulders KW - Muscles (fatigue) KW - Movement KW - Athletes KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746273151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Effect+of+Rotator+Cuff+Muscle+Imbalance+on+Forceful+Internal+Impingement+and+Peel-Back+of+the+Superior+Labrum.+A+Cadaveric+Study&rft.au=Mihata%2C+Teruhisa%3BGates%2C+Jeffrey%3BMcGarry%2C+Michelle+H%3BLee%2C+Jason%3BKinoshita%2C+Mitsuo%3BLee%2C+Thay+Q&rft.aulast=Mihata&rft.aufirst=Teruhisa&rft.date=2009-11-01&rft.volume=37&rft.issue=11&rft.spage=2222&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F0363546509337450 LA - English DB - Physical Education Index N1 - Date revised - 2010-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Throwing; Strength; Muscles; Stress; Rotator cuff; Shoulders; Muscles (fatigue); Movement; Athletes DO - http://dx.doi.org/10.1177/0363546509337450 ER - TY - JOUR T1 - The influence of pre-deployment neurocognitive functioning on post-deployment PTSD symptom outcomes among Iraq-deployed Army soldiers. AN - 742782321; pmid-19891817 AB - This study evaluated associations between pre-deployment neurocognitive performance and post-deployment posttraumatic stress disorder (PTSD) symptoms in a sample of deployed active duty Army soldiers. As part of a larger longitudinal study, each participant completed baseline measures of memory, executive attention, and response inhibition, and baseline and post-deployment self-report measures of PTSD symptom severity. Data were subjected to multiple regression analyses that examined associations between baseline neurocognitive performances and longitudinal PTSD symptom outcome. Results revealed that pre-trauma immediate recall of visual information was associated with post-deployment PTSD symptom severity, even after controlling for pre-deployment PTSD symptom levels, combat intensity, age, gender, and test-retest interval. There was also an interaction between pre-deployment PTSD symptom severity and pre-deployment immediate visual recall and verbal learning, indicating that neurocognitive performances were more strongly (and negatively) associated with residualized post-deployment PTSD symptoms at higher levels of pre-deployment PTSD symptoms. These findings highlight the potential role of pre-trauma neurocognitive functioning in moderating the effects of trauma exposure on PTSD symptoms JF - Journal of the International Neuropsychological Society : JINS AU - Marx, Brian P AU - Doron-Lamarca, Susan AU - Proctor, Susan P AU - Vasterling, Jennifer J AD - VA Boston Healthcare System, Behavioral Science Division, National Center for PTSD, Boston, MA 02130, USA. brian.marx@va.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 840 EP - 852 VL - 15 IS - 6 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - United States KW - Severity of Illness Index KW - Young Adult KW - Databases, Factual -- statistics & numerical data KW - Questionnaires KW - Reproducibility of Results KW - Humans KW - Learning -- physiology KW - Retrospective Studies KW - Iraq KW - Cross-Sectional Studies KW - Psychiatric Status Rating Scales KW - Risk Factors KW - Health Surveys KW - Adult KW - Military Personnel -- psychology KW - Attention -- physiology KW - Neuropsychological Tests KW - Male KW - Female KW - Cognition Disorders -- etiology KW - Stress Disorders, Post-Traumatic -- psychology KW - Stress Disorders, Post-Traumatic -- complications KW - Cognition Disorders -- psychology KW - Military Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742782321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=The+influence+of+pre-deployment+neurocognitive+functioning+on+post-deployment+PTSD+symptom+outcomes+among+Iraq-deployed+Army+soldiers.&rft.au=Marx%2C+Brian+P%3BDoron-Lamarca%2C+Susan%3BProctor%2C+Susan+P%3BVasterling%2C+Jennifer+J&rft.aulast=Marx&rft.aufirst=Brian&rft.date=2009-11-01&rft.volume=15&rft.issue=6&rft.spage=840&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Hippocampal volume and declarative memory function in combat-related PTSD. AN - 742781940; pmid-19703322 AB - The proposition that declarative memory deficits are systematically related to smaller hippocampal volume was tested in a relatively large sample (n = 95) of U.S. military veterans with and without combat-related posttraumatic stress disorder. This correlative analysis was extended by including multiple measures of verbal and visual declarative memory and multiple memory-relevant regional brain volumes that had been shown to exhibit main effects of PTSD in prior work. Small-to-moderate effects were observed on verbal declarative memory in line with a recent meta-analysis; nevertheless, little or no evidence of systematic linear covariation between memory measures and brain volumes was observed. JF - Journal of the International Neuropsychological Society : JINS AU - Woodward, Steven H AU - Kaloupek, Danny G AU - Grande, Laura J AU - Stegman, Wendy K AU - Kutter, Catherine J AU - Leskin, Loraine AU - Prestel, Rebecca AU - Schaer, Marie AU - Reiss, Allan L AU - Eliez, Stephan AD - Dissemination and Training Division, National Center for PTSD, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA. steve.woodward@va.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 830 EP - 839 VL - 15 IS - 6 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Veterans KW - Brain Mapping KW - Analysis of Variance KW - Psychiatric Status Rating Scales KW - Alcoholism -- pathology KW - Magnetic Resonance Imaging -- methods KW - Humans KW - Adult KW - Learning -- physiology KW - Middle Aged KW - Statistics as Topic KW - Neuropsychological Tests KW - Alcoholism -- complications KW - Psychometrics KW - Male KW - Stress Disorders, Post-Traumatic -- complications KW - Combat Disorders -- complications KW - Memory Disorders -- etiology KW - Hippocampus -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742781940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Hippocampal+volume+and+declarative+memory+function+in+combat-related+PTSD.&rft.au=Woodward%2C+Steven+H%3BKaloupek%2C+Danny+G%3BGrande%2C+Laura+J%3BStegman%2C+Wendy+K%3BKutter%2C+Catherine+J%3BLeskin%2C+Loraine%3BPrestel%2C+Rebecca%3BSchaer%2C+Marie%3BReiss%2C+Allan+L%3BEliez%2C+Stephan&rft.aulast=Woodward&rft.aufirst=Steven&rft.date=2009-11-01&rft.volume=15&rft.issue=6&rft.spage=830&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Desmoplasia of pancreatic ductal adenocarcinoma. AN - 734128164; 19896098 AB - Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and is characterized by remarkable desmoplasia. The desmoplasia is composed of extracellular matrix (ECM) proteins, myofibroblastic pancreatic stellate cells, and immune cells associated with a multitude of cytokines, growth factors, and ECM metabolizing enzymes. The mechanisms of participation of this complex matrix process in carcinogenesis are only starting to be appreciated. Recent studies showed key roles for stellate cells in the production of ECM proteins as well as cytokines and growth factors that promote the growth of the cancer cells all present in the desmoplastic parts of PDAC. In addition, interactions of ECM proteins and desmoplastic secreted growth factors with the cancer cells of PDAC activate intracellular signals including reactive oxygen species that act to make the cancer cells resistant to dying. These findings suggest that the desmoplasia of PDAC is a key factor in regulating carcinogenesis of PDAC as well as responses to therapies. A better understanding of the biology of desmoplasia in the mechanism of PDAC will likely provide significant opportunities for better treatments for this devastating cancer. JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association AU - Pandol, Stephen AU - Edderkaoui, Mouad AU - Gukovsky, Ilya AU - Lugea, Aurelia AU - Gukovskaya, Anna AD - Pancreatic Research Group, Department of Medicine, VA Greater Los Angeles Health Care System and University of California, Los Angeles, California, USA. stephen.pandol@va.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - S44 EP - S47 VL - 7 IS - 11 Suppl KW - Inflammation Mediators KW - 0 KW - Index Medicus KW - Inflammation Mediators -- analysis KW - Humans KW - Models, Biological KW - Signal Transduction KW - Adenocarcinoma -- complications KW - Fibroma, Desmoplastic -- pathology KW - Carcinoma, Pancreatic Ductal -- pathology KW - Carcinoma, Pancreatic Ductal -- complications KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734128164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+gastroenterology+and+hepatology+%3A+the+official+clinical+practice+journal+of+the+American+Gastroenterological+Association&rft.atitle=Desmoplasia+of+pancreatic+ductal+adenocarcinoma.&rft.au=Pandol%2C+Stephen%3BEdderkaoui%2C+Mouad%3BGukovsky%2C+Ilya%3BLugea%2C+Aurelia%3BGukovskaya%2C+Anna&rft.aulast=Pandol&rft.aufirst=Stephen&rft.date=2009-11-01&rft.volume=7&rft.issue=11+Suppl&rft.spage=S44&rft.isbn=&rft.btitle=&rft.title=Clinical+gastroenterology+and+hepatology+%3A+the+official+clinical+practice+journal+of+the+American+Gastroenterological+Association&rft.issn=1542-7714&rft_id=info:doi/10.1016%2Fj.cgh.2009.07.039 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-12 N1 - Date created - 2009-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cgh.2009.07.039 ER - TY - JOUR T1 - Mental illness and substance use disorders among women veterans with diabetes. AN - 734120795; 19879456 AB - We sought to estimate the prevalence of mental illness (MI) and substance use disorders (SUD) and determine the predictors of MI/SUD categories among veteran women with diabetes. We evaluated a cross-sectional analysis of 16,368 women veterans with diabetes in fiscal 1999 and 2000. SUD, MI, and diabetes were identified using validated algorithms based on diagnosis codes. Chi-square and multinomial logistic regressions were used to examine associations between SUD, MI, demographic, socioeconomic, and health status variables. Overall, 45% of women had a MI, SUD, or both. SUD rates were high among those with serious MI. The associations between MI/SUD and independent variables were not uniformly significant, except for macrovascular conditions; women veterans were more likely to have combinations of MI/SUD. A high rate of MI/SUD suggests that care for mental and physical illness needs to be integrated into health care planning and delivery of services to veteran women with diabetes. JF - Women's health issues : official publication of the Jacobs Institute of Women's Health AU - Banerjea, Ranjana AU - Pogach, Leonard M AU - Smelson, David AU - Sambamoorthi, Usha AD - Department of Veterans Affairs New Jersey Healthcare System, Center for Health Care Knowledge Management, East Orange, New Jersey, USA. Ranjana.Banerjea@va.gov PY - 2009 SP - 446 EP - 456 VL - 19 IS - 6 KW - Index Medicus KW - Socioeconomic Factors KW - Cross-Sectional Studies KW - Medicare -- statistics & numerical data KW - United States Department of Veterans Affairs KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Prevalence KW - Veterans -- statistics & numerical data KW - Mental Disorders -- epidemiology KW - Veterans -- psychology KW - Diabetes Mellitus -- epidemiology KW - Substance-Related Disorders -- complications KW - Mental Disorders -- complications KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734120795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+health+issues+%3A+official+publication+of+the+Jacobs+Institute+of+Women%27s+Health&rft.atitle=Mental+illness+and+substance+use+disorders+among+women+veterans+with+diabetes.&rft.au=Banerjea%2C+Ranjana%3BPogach%2C+Leonard+M%3BSmelson%2C+David%3BSambamoorthi%2C+Usha&rft.aulast=Banerjea&rft.aufirst=Ranjana&rft.date=2009-11-01&rft.volume=19&rft.issue=6&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Women%27s+health+issues+%3A+official+publication+of+the+Jacobs+Institute+of+Women%27s+Health&rft.issn=1878-4321&rft_id=info:doi/10.1016%2Fj.whi.2009.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-07 N1 - Date created - 2009-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.whi.2009.07.007 ER - TY - JOUR T1 - Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway. AN - 67692748; 19770404 AB - Locally produced dopamine in the renal proximal tubule inhibits salt and fluid reabsorption, and a dysfunctional intrarenal dopaminergic system has been reported in essential hypertension and experimental hypertension models. Using catechol-O-methyl-transferase knockout (COMT(-/-)) mice, which have increased renal dopamine because of deletion of the major renal dopamine-metabolizing enzyme, we investigated the effect of intrarenal dopamine on the development of hypertension in the deoxycorticosterone acetate/high-salt (DOCA/HS) model. DOCA/HS led to significant increases in systolic blood pressure in wild-type mice (from 115+/-2 to 153+/-4 mm Hg), which was significantly attenuated in COMT(-/-) mice (from 114+/-2 to 135+/-3 mm Hg). In DOCA/HS COMT(-/-) mice, the D1-like receptor antagonist SCH-23390 increased systolic blood pressure (156+/-2 mm Hg). DOCA/HS COMT(-/-) mice also exhibited more urinary sodium excretion (COMT(-/-) versus wild-type: 3038+/-430 versus 659+/-102 micromol/L per 24 hours; P<0.01). Furthermore, DOCA/HS-induced renal oxidative stress was significantly attenuated in COMT(-/-) mice. COX-2-derived prostaglandins in the renal medulla promote sodium excretion, and dopamine stimulates medullary prostaglandin production. Renal medullary COX-2 expression and urinary prostaglandin E2 excretion were significantly higher in COMT(-/-) than in wild-type mice after DOCA/HS treatment. In DOCA/HS-treated COMT(-/-) mice, the COX-2 inhibitor SC-58236 reduced urinary sodium and prostaglandin E(2) excretion and increased systolic blood pressure (153+/-2 mm Hg). These studies indicate that an activated renal dopaminergic system attenuates the development of hypertension, at least in large part through activating medullary COX-2 expression/activity, and also decreases oxidative stress resulting from DOCA/HS. JF - Hypertension (Dallas, Tex. : 1979) AU - Yao, Bing AU - Harris, Raymond C AU - Zhang, Ming-Zhi AD - Nashville Veterans' Administration Hospital and Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1077 EP - 1083 VL - 54 IS - 5 KW - Benzazepines KW - 0 KW - SCH 23390 KW - Sodium Chloride, Dietary KW - Desoxycorticosterone KW - 40GP35YQ49 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Dinoprostone KW - K7Q1JQR04M KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Probability KW - Animals KW - Analysis of Variance KW - Benzazepines -- pharmacology KW - Random Allocation KW - Blood Pressure Determination KW - Disease Models, Animal KW - Mice KW - Mice, Knockout KW - Blotting, Western KW - Sodium Chloride, Dietary -- adverse effects KW - Desoxycorticosterone -- adverse effects KW - Sodium Chloride, Dietary -- pharmacology KW - Dinoprostone -- metabolism KW - Desoxycorticosterone -- pharmacology KW - Immunohistochemistry KW - Hypertension -- physiopathology KW - Kidney Medulla -- metabolism KW - Kidney Medulla -- drug effects KW - Dopamine -- metabolism KW - Cyclooxygenase 2 -- metabolism KW - Kidney Medulla -- pathology KW - Hypertension -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67692748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Intrarenal+dopamine+attenuates+deoxycorticosterone+acetate%2Fhigh+salt-induced+blood+pressure+elevation+in+part+through+activation+of+a+medullary+cyclooxygenase+2+pathway.&rft.au=Yao%2C+Bing%3BHarris%2C+Raymond+C%3BZhang%2C+Ming-Zhi&rft.aulast=Yao&rft.aufirst=Bing&rft.date=2009-11-01&rft.volume=54&rft.issue=5&rft.spage=1077&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=1524-4563&rft_id=info:doi/10.1161%2FHYPERTENSIONAHA.109.137174 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-12 N1 - Date created - 2009-10-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Physiol Renal Physiol. 2005 Apr;288(4):F840-5 [15613619] J Clin Invest. 1999 Apr;103(7):953-61 [10194467] Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R96-R104 [16352863] J Cardiovasc Pharmacol. 2006;47 Suppl 1:S37-42 [16785827] Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):16045-50 [17043228] Nat Clin Pract Nephrol. 2006 Nov;2(11):637-50 [17066056] Eur J Pharmacol. 2006 Dec 15;552(1-3):131-4 [17064681] Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17985-90 [17090678] Hypertension. 2007 Mar;49(3):672-8 [17190875] Am J Physiol Renal Physiol. 2007 Sep;293(3):F723-31 [17596522] Hypertension. 2008 Feb;51(2):367-75 [18158345] Hypertension. 2008 May;51(5):1358-65 [18391098] Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H281-8 [18487445] Pediatr Nephrol. 2008 Dec;23(12):2131-46 [18615257] Am J Physiol Cell Physiol. 2008 Nov;295(5):C1326-31 [18799649] Hypertension. 2009 Mar;53(3):564-70 [19139376] Clin Exp Hypertens. 2009 Apr;31(2):156-78 [19330604] Circulation. 2000 May 16;101(19):2302-8 [10811599] Annu Rev Physiol. 2000;62:621-47 [10845105] Hypertension. 2000 Aug;36(2):276-81 [10948090] J Hypertens. 2001 Apr;19(4):741-8 [11330877] Circ Res. 2001 May 11;88(9):947-53 [11349005] Hypertension. 2001 Sep;38(3):297-302 [11566894] Am J Physiol Renal Physiol. 2002 Aug;283(2):F309-18 [12110515] Am J Physiol Renal Physiol. 2002 Sep;283(3):F509-16 [12167602] J Hypertens. 2003 Jan;21(1):199-207 [12544452] Curr Opin Nephrol Hypertens. 2003 Mar;12(2):189-94 [12589180] J Hypertens. 2003 Dec;21(12):2365-74 [14654758] Physiol Genomics. 2004 Nov 17;19(3):233-46 [15548830] Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H55-61 [15598876] Free Radic Biol Med. 2004 May 15;36(10):1233-40 [15110388] Am J Physiol Renal Physiol. 2004 Jun;286(6):F1120-6 [14970001] J Pharmacol Exp Ther. 1974 Feb;188(2):453-60 [4359555] Biochem J. 1976 Feb 15;154(2):257-64 [7235] Am J Physiol. 1981 Jun;240(6):F471-80 [7018256] Am J Hypertens. 1990 Jun;3(6 Pt 2):108S-111S [1974438] Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3170-4 [2014237] Science. 1991 Jun 28;252(5014):1813-6 [2063193] J Clin Invest. 1994 Dec;94(6):2504-10 [7989609] J Clin Invest. 1996 Apr 15;97(8):1916-23 [8621776] J Clin Invest. 1996 Jun 15;97(12):2745-52 [8675685] Prog Lipid Res. 1997 Mar;36(1):1-21 [9373618] Am J Physiol. 1997 Dec;273(6 Pt 2):F994-1002 [9435689] J Hypertens. 1998 May;16(5):601-8 [9797171] Am J Physiol Regul Integr Comp Physiol. 2005 Jun;288(6):R1767-73 [15718388] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.137174 ER - TY - JOUR T1 - Intravenous zoledronic acid to prevent osteoporosis in a veteran population with multiple risk factors for bone loss on androgen deprivation therapy. AN - 67685808; 19758618 AB - Androgen deprivation therapy for prostate cancer is associated with osteoporosis and increased fracture risk. Previous studies of zoledronic acid demonstrated bone loss prevention in patients initiating androgen deprivation therapy. There are limited data on patients on prolonged androgen deprivation therapy or in Veterans Affairs patients with multiple risk factors for osteoporosis. We randomized 93 patients with M0 prostate cancer in this placebo controlled trial in the Veterans Affairs health care system. Preplanned strata included 50 patients on androgen deprivation therapy for less than 1 year (stratum 1) and 43 on androgen deprivation therapy for greater than 1 year (stratum 2). In each stratum patients were randomized to 4 mg zoledronic acid intravenously every 3 months for 4 treatments or intravenous placebo. The primary end point was the percent change in bone mineral density at the lumbar spine at 12 months. Age, race, body mass index and osteoporosis risk factors were similar for the 2 treatments. Most patients were former smokers, had moderate alcohol intake, were not on calcium/vitamin D supplements and were relatively sedentary at baseline. In stratum 1 spine bone mineral density increased 5.95% in the zoledronic acid arm and decreased 3.23% in the placebo arm (p = 0.0044). In stratum 2 spine bone mineral density increased 6.08% in the zoledronic acid arm and only increased 1.57% in the placebo arm (p = 0.0005). Treatment was well tolerated with minimal impact on renal function. Zoledronic acid improved bone mineral density in patients with M0 prostate cancer on androgen deprivation therapy for 1 year or less, or greater than 1 year. This finding indicates that bisphosphonate therapy remains effective when initiated later in the course of androgen deprivation therapy and is efficacious in Veterans Affairs patients with multiple risk factors for osteoporosis. JF - The Journal of urology AU - Bhoopalam, Nirmala AU - Campbell, Steven C AU - Moritz, Thomas AU - Broderick, William R AU - Iyer, Padmini AU - Arcenas, Anthony G AU - Van Veldhuizen, Peter J AU - Friedman, Nicholas AU - Reda, Domenic AU - Warren, Stuart AU - Garewal, Harinder AD - Edward Hines, Jr Veterans Affairs Hospital, Hines, Illinois 60141, USA. nirmala.bhoopalam@va.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 2257 EP - 2264 VL - 182 IS - 5 KW - Androgen Antagonists KW - 0 KW - Bone Density Conservation Agents KW - Diphosphonates KW - Imidazoles KW - zoledronic acid KW - 6XC1PAD3KF KW - Abridged Index Medicus KW - Index Medicus KW - Veterans KW - Infusions, Intravenous KW - Risk Factors KW - Humans KW - Aged KW - Prostatic Neoplasms -- drug therapy KW - Male KW - Osteoporosis -- prevention & control KW - Androgen Antagonists -- adverse effects KW - Androgen Antagonists -- therapeutic use KW - Imidazoles -- administration & dosage KW - Diphosphonates -- administration & dosage KW - Osteoporosis -- chemically induced KW - Bone Density Conservation Agents -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67685808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Intravenous+zoledronic+acid+to+prevent+osteoporosis+in+a+veteran+population+with+multiple+risk+factors+for+bone+loss+on+androgen+deprivation+therapy.&rft.au=Bhoopalam%2C+Nirmala%3BCampbell%2C+Steven+C%3BMoritz%2C+Thomas%3BBroderick%2C+William+R%3BIyer%2C+Padmini%3BArcenas%2C+Anthony+G%3BVan+Veldhuizen%2C+Peter+J%3BFriedman%2C+Nicholas%3BReda%2C+Domenic%3BWarren%2C+Stuart%3BGarewal%2C+Harinder&rft.aulast=Bhoopalam&rft.aufirst=Nirmala&rft.date=2009-11-01&rft.volume=182&rft.issue=5&rft.spage=2257&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=1527-3792&rft_id=info:doi/10.1016%2Fj.juro.2009.07.046 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-30 N1 - Date created - 2009-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.juro.2009.07.046 ER - TY - JOUR T1 - Darfur Refugees in Cairo: Mental Health and Interpersonal Conflict in the Aftermath of Genocide AN - 60336058; 201008966 AB - Hundreds of thousands of Darfur people affected by the Sudanese genocide have fled to Cairo, Egypt, in search of assistance. Collaborating with Africa and Middle East Refugee Assistance (AMERA), the authors conducted a mental health care needs assessment among Darfur refugees in Cairo. Information was collected using individual and focus group interviews to identify gaps in mental health care and develop understandings of emotional and relationship problems. The refugee mental health care system has a piecemeal structure with gaps in outpatient services. There is moderate to severe emotional distress among many Darfur refugees, including symptoms of depression and trauma, and interpersonal conflict, both domestic violence and broader community conflict, elevated relative to pregenocide levels. Given the established relationships between symptoms of depression/traumatic stress and interpersonal violence, improving mental health is important for both preventing mental health decompensation and stemming future cycles of intra- and intergroup conflict. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Journal of Interpersonal Violence AU - Meffert, Susan M AU - Marmar, Charles R AD - University of California, San Francisco and San Francisco Veterans Administration Medical Center smeffert@lppi.ucsf.edu Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1835 EP - 1848 PB - Sage Publications, Thousand Oaks CA VL - 24 IS - 11 SN - 0886-2605, 0886-2605 KW - refugee trauma violence Sudan Darfur KW - Cairo, Egypt KW - Depression (Psychology) KW - Interpersonal Conflict KW - Family Violence KW - Mental Health KW - Genocide KW - Mental Health Services KW - Refugees KW - Trauma KW - article KW - 2858: studies in violence; studies in violence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60336058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interpersonal+Violence&rft.atitle=Darfur+Refugees+in+Cairo%3A+Mental+Health+and+Interpersonal+Conflict+in+the+Aftermath+of+Genocide&rft.au=Meffert%2C+Susan+M%3BMarmar%2C+Charles+R&rft.aulast=Meffert&rft.aufirst=Susan&rft.date=2009-11-01&rft.volume=24&rft.issue=11&rft.spage=1835&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interpersonal+Violence&rft.issn=08862605&rft_id=info:doi/10.1177%2F0886260508325491 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 26 N1 - Last updated - 2016-09-28 N1 - CODEN - JIVIEI N1 - SubjectsTermNotLitGenreText - Refugees; Depression (Psychology); Mental Health; Mental Health Services; Cairo, Egypt; Interpersonal Conflict; Family Violence; Genocide; Trauma DO - http://dx.doi.org/10.1177/0886260508325491 ER - TY - JOUR T1 - Suicidality and Veterans With a History of Traumatic Brain Injury: Precipitating Events, Protective Factors, and Prevention Strategies AN - 57354808; 201006205 AB - Objectives: To increase understanding regarding precipitating and preventative factors of suicidal behavior and to highlight past experiences and recommendations regarding services aimed at suicide prevention among Veterans with a history of traumatic brain injury (TBI). Study Design: Qualitative. Participants: Sample of 13 Veterans with a history of TBI, and a history of clinically significant suicidal ideation or behavior. Method: In-person interviews were conducted and data were analyzed using a hermeneutic approach. Results: Shared precipitants noted included loss-of-self post-TBI, cognitive sequelae, and psychiatric and emotional disturbances. Common protective factors noted included social supports, a sense of purpose regarding the future, religion and spirituality, and mental health care. Means of improving care were also identified (e.g., increasing the availability of services and mental health professionals' knowledge regarding TBI, providing more structured treatment). Conclusions: Findings highlight potential areas of importance in the assessment and treatment of suicidal Veterans with a history of TBI. Recommendations regarding means of improving care are also presented. [Copyright The American Psychological Association.] JF - Rehabilitation Psychology AU - Brenner, Lisa A AU - Homaifar, Beeta Y AU - Adler, Lawrence E AU - Wolfman, Jessica H AU - Kemp, Jan AD - VISN 19 Mental Illness Research, Education, and Clinical Center (MIRECC lisa.brenner@va.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 390 EP - 397 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 54 IS - 4 SN - 0090-5550, 0090-5550 KW - suicide traumatic brain injury Veterans qualitative KW - Veterans KW - Suicidal behaviour KW - Protective factors KW - Quality of care KW - Spirituality KW - Traumatic brain injury KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57354808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rehabilitation+Psychology&rft.atitle=Suicidality+and+Veterans+With+a+History+of+Traumatic+Brain+Injury%3A+Precipitating+Events%2C+Protective+Factors%2C+and+Prevention+Strategies&rft.au=Brenner%2C+Lisa+A%3BHomaifar%2C+Beeta+Y%3BAdler%2C+Lawrence+E%3BWolfman%2C+Jessica+H%3BKemp%2C+Jan&rft.aulast=Brenner&rft.aufirst=Lisa&rft.date=2009-11-01&rft.volume=54&rft.issue=4&rft.spage=390&rft.isbn=&rft.btitle=&rft.title=Rehabilitation+Psychology&rft.issn=00905550&rft_id=info:doi/10.1037%2Fa0017802 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Veterans; Suicidal behaviour; Traumatic brain injury; Quality of care; Protective factors; Spirituality DO - http://dx.doi.org/10.1037/a0017802 ER - TY - JOUR T1 - Cardiac Stress Testing in Women AN - 57346227; 201007598 AB - More women die every year from cardiovascular disease (CVD) than from any other cause. Non-invasive cardiac stress testing is key to timely diagnosis and treatment of CVD. However, providers need to be aware of how testing accuracy differs between men and women. This article reviews the standard non-invasive tests available, the sensitivity and specificity of each test, and how to choose the most appropriate test for female patients. It also discusses several new testing modes on the horizon. [Copyright Elsevier B.V.] JF - The Journal for Nurse Practitioners AU - McCaffery, Jennifer T AU - Geraci, Stephen A Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 760 EP - 766 PB - Elsevier Ltd, The Netherlands VL - 5 IS - 10 SN - 1555-4155, 1555-4155 KW - coronary artery disease diagnosis electrocardiography exercise test nuclear women KW - Sensitivity KW - Diagnostic testing KW - Women KW - Non-invasive KW - Stress KW - Cardiovascular diseases KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57346227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+for+Nurse+Practitioners&rft.atitle=Cardiac+Stress+Testing+in+Women&rft.au=McCaffery%2C+Jennifer+T%3BGeraci%2C+Stephen+A&rft.aulast=McCaffery&rft.aufirst=Jennifer&rft.date=2009-11-01&rft.volume=5&rft.issue=10&rft.spage=760&rft.isbn=&rft.btitle=&rft.title=The+Journal+for+Nurse+Practitioners&rft.issn=15554155&rft_id=info:doi/10.1016%2Fj.nurpra.2008.10.017 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cardiovascular diseases; Stress; Women; Non-invasive; Sensitivity; Diagnostic testing DO - http://dx.doi.org/10.1016/j.nurpra.2008.10.017 ER - TY - JOUR T1 - Are gender differences in colorectal cancer screening rates due to differences in self-reporting? AN - 57343824; 201006884 AB - Objective Studies have found that women are less likely than men to undergo colorectal cancer (CRC) screening. While one source of these disparities may be gender differences in barriers and facilitators to screening, another may be differences in reporting bias. Method In this study of 345 male and female veterans, conducted in 2006 in Minneapolis, MN, we examined CRC screening adherence rates by gender using medical records and self-report and assessed whether any differences were due to reporting bias. Results We found a significantly higher rate of colonoscopy use among men when using self-report data, but no significant differences in either overall or test-specific screening adherence when using medical record data. Analyses examining the prevalence and determinants of concordance between self-report and medical records screening revealed that compared to women, men were less accurate in reporting sigmoidoscopy and colonoscopy and over-reported screening by colonoscopy. Men were also more likely to have missing self-report data and how missing data were handled affected differences in screening behavior. Accuracy in screening behavior was not explained by demographic variables, good physical or mental health, or physician recommendation for screening. Conclusions Reported gender disparities in CRC screening adherence may be a result of reporting bias. [Copyright Elsevier B.V.] JF - Preventive Medicine AU - Griffin, Joan M AU - Burgess, Diana AU - Vernon, Sally W AU - Friedemann-Sanchez, Greta AU - Powell, Adam AU - van Ryn, Michelle AU - Halek, Krysten AU - Noorbaloochi, Siamak AU - Grill, Joe AU - Bloomfield, Hanna AU - Partin, Melissa AD - Center for Chronic Disease Outcomes Research (CCDOR), Minneapolis VA Medical Center, Minneapolis, MN, USA joan.griffin2@va.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 436 EP - 441 PB - Elsevier Ltd, The Netherlands VL - 49 IS - 5 SN - 0091-7435, 0091-7435 KW - Gender Colorectal cancer Screening Adherence Bias Self-report Medical record KW - Screening KW - Colonoscopy KW - Colorectal cancer KW - Selfreport KW - Gender differences KW - Bias KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57343824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=Are+gender+differences+in+colorectal+cancer+screening+rates+due+to+differences+in+self-reporting%3F&rft.au=Griffin%2C+Joan+M%3BBurgess%2C+Diana%3BVernon%2C+Sally+W%3BFriedemann-Sanchez%2C+Greta%3BPowell%2C+Adam%3Bvan+Ryn%2C+Michelle%3BHalek%2C+Krysten%3BNoorbaloochi%2C+Siamak%3BGrill%2C+Joe%3BBloomfield%2C+Hanna%3BPartin%2C+Melissa&rft.aulast=Griffin&rft.aufirst=Joan&rft.date=2009-11-01&rft.volume=49&rft.issue=5&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2009.09.013 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Screening; Gender differences; Colorectal cancer; Selfreport; Colonoscopy; Bias DO - http://dx.doi.org/10.1016/j.ypmed.2009.09.013 ER - TY - JOUR T1 - Depressive Symptoms And Affective Reactivity To Maternal Praise And Criticism AN - 57342566; 201002603 AB - Despite decades of research documenting evidence that Expressed Emotion (EE) leads to relapse, little research has been performed to show whether depression is related to affective reactivity to criticism. This study examined how depression relates to affect after an analog of EE. Participants' mothers were asked to write praising, critical, and neutral letters about the participants, who later read these letters and completed affect measures. Current diagnosis of depression predicted more negative affect after critical letters, even after controlling neutral letter affect and judges' ratings of the letter. After controlling for neutral letter affect and judges' ratings of the praise letter, current depression did not predict less positive affect after praise letters. Lifetime depression did not predict affect. Adapted from the source document. JF - Journal of Social and Clinical Psychology AU - Cuellar, Amy K AU - Johnson, Sheri L AD - Michael E. DeBakey VA Medical Center, U6MHCL-CIP, 2002 Holcombe Blvd., Houston, TX 77030 E-mail: AmyK.Cuellar@va.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1173 EP - 1194 PB - Guilford Press, New York NY VL - 28 IS - 9 SN - 0736-7236, 0736-7236 KW - Praise KW - Depression KW - Expressed emotions KW - Reactivity KW - Positive affect KW - Judges KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57342566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+and+Clinical+Psychology&rft.atitle=Depressive+Symptoms+And+Affective+Reactivity+To+Maternal+Praise+And+Criticism&rft.au=Cuellar%2C+Amy+K%3BJohnson%2C+Sheri+L&rft.aulast=Cuellar&rft.aufirst=Amy&rft.date=2009-11-01&rft.volume=28&rft.issue=9&rft.spage=1173&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+and+Clinical+Psychology&rft.issn=07367236&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-02-03 N1 - Last updated - 2016-09-27 N1 - CODEN - JSCPFF N1 - SubjectsTermNotLitGenreText - Depression; Expressed emotions; Praise; Reactivity; Judges; Positive affect ER - TY - JOUR T1 - Disseminating Evidence-Based Treatments for PTSD in Organizational Settings: A High Priority Focus Area AN - 57337456; 201005440 AB - Dissemination of evidence-based treatments for PTSD has become an important focus of activity in the aftermath of recent terrorist attacks (e.g., London underground and U.S. 9/11 attacks), natural disasters (e.g., Indian Ocean tsunami and Hurricane Katrina), and wars (e.g., in Iraq and Afghanistan). This has become a high priority need for all mental health training and service delivery organizations. Researchers and educators have begun to examine clinician and client perceptions and preferences regarding PTSD treatment processes, and health care systems are organizing more comprehensive efforts at training and system change. As this evolution of services moves forward, effective dissemination should be a major focus of health policy research for the next decade or more. Adapted from source document. JF - Behaviour Research and Therapy AU - Ruzek, Josef I AU - Rosen, Raymond C AD - National Center PTSD, VA Palo Alto Health Care System, Menlo Park, CA josef.ruzek@va.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 980 EP - 989 PB - Elsevier, Amsterdam The Netherlands VL - 47 IS - 11 SN - 0005-7967, 0005-7967 KW - Dissemination KW - PTSD KW - Evidence-based KW - Aftermath KW - Posttraumatic stress disorder KW - Priorities KW - Afghanistan KW - Natural disasters KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57337456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behaviour+Research+and+Therapy&rft.atitle=Disseminating+Evidence-Based+Treatments+for+PTSD+in+Organizational+Settings%3A+A+High+Priority+Focus+Area&rft.au=Ruzek%2C+Josef+I%3BRosen%2C+Raymond+C&rft.aulast=Ruzek&rft.aufirst=Josef&rft.date=2009-11-01&rft.volume=47&rft.issue=11&rft.spage=980&rft.isbn=&rft.btitle=&rft.title=Behaviour+Research+and+Therapy&rft.issn=00057967&rft_id=info:doi/10.10.10%2Fj.brat.2009.07.008 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-03-05 N1 - Last updated - 2016-09-27 N1 - CODEN - BRTHAA N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Dissemination; Priorities; Aftermath; Afghanistan; Natural disasters DO - http://dx.doi.org/10.10.10/j.brat.2009.07.008 ER - TY - JOUR T1 - Hepatitis C in an Urban Cohort: Who's Not Being Treated? AN - 57330961; 201003708 AB - Hepatitis C virus (HCV) remains widely prevalent in the U.S. Treatment has improved, but rates of treatment initiation remain low. We sought to identify clinical and sociodemographic characteristics of patients that are associated with failure to initiate treatment of HCV infection. We conducted a retrospective cohort study in our primary care hepatitis C treatment clinic, affiliated with an urban academic hospital. Our population was multi-ethnic, HIV -, HCV+, treatment naive patients. We measured rates of HCV treatment initiation and sociodemographic, viral, and patient-related variables associated with non-initiation of treatment. The total number of treatment-eligible patients was 168, of whom 41 began treatment and 127 did not. In multivariate analysis, individuals with HCV genotypes 1 and 4 were less likely than others to initiate treatment, as were patients with more medical comorbidities. Further research is needed to understand how factors around initiation interact and how interventions can overcome them. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Alfandre, David AU - Gardenier, Donald AU - Federman, Alex AU - McGinn, Thomas AD - National Center for Ethics in Health Care, 423 East 23rd St. (JOE), New York, NY 10010; (212) 951-3306 david.alfandre@va.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1068 EP - 1078 PB - John Hopkins University Press, Baltimore MD VL - 20 IS - 4 SN - 1049-2089, 1049-2089 KW - Hepatitis C, treatment, underserved KW - Initiation KW - Sociodemographic aspects KW - Clinics KW - Hepatitis C KW - Comorbidity KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57330961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Hepatitis+C+in+an+Urban+Cohort%3A+Who%27s+Not+Being+Treated%3F&rft.au=Alfandre%2C+David%3BGardenier%2C+Donald%3BFederman%2C+Alex%3BMcGinn%2C+Thomas&rft.aulast=Alfandre&rft.aufirst=David&rft.date=2009-11-01&rft.volume=20&rft.issue=4&rft.spage=1068&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-03-05 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Hepatitis C; Initiation; Sociodemographic aspects; Hospitals; Clinics; Comorbidity ER - TY - CPAPER T1 - Odds ratios of externalizing and internalizing disorders: An approach to service design within and across cultures T2 - 2009 Conference on Australasian Professional Society on Alcohol and other Drugs (APSAD 2009) AN - 42077147; 5521254 JF - 2009 Conference on Australasian Professional Society on Alcohol and other Drugs (APSAD 2009) AU - Westermeyer, Joe Y1 - 2009/11/01/ PY - 2009 DA - 2009 Nov 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42077147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Australasian+Professional+Society+on+Alcohol+and+other+Drugs+%28APSAD+2009%29&rft.atitle=Odds+ratios+of+externalizing+and+internalizing+disorders%3A+An+approach+to+service+design+within+and+across+cultures&rft.au=Westermeyer%2C+Joe&rft.aulast=Westermeyer&rft.aufirst=Joe&rft.date=2009-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Australasian+Professional+Society+on+Alcohol+and+other+Drugs+%28APSAD+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.apsadconference.com.au/wp-content/uploads/20091014-program- handbook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Antibodies to DNA: infection or genetics? AN - 21488537; 12506617 AB - Antibodies to DNA (anti-DNA) are the serological hallmark of systemic lupus erythematosus (SLE) and unique markers of the immunological disturbances critical to disease pathogenesis. In the form of immune complexes, anti-DNA autoantibodies can deposit in the tissue to incite inflammation and damage; in addition, these complexes can induce cytokine production, most prominently, type 1 interferon. Studies in both patients and animal models have implicated genetic as well as environmental factors in the aetiology of the anti-DNA response. Because bacterial DNA is a potent stimulant of innate immunity by both toll-like receptor (TLR) and non-TLR signalling pathways, foreign DNA introduced during the course of bacterial or viral infection could have a dual role in antibody induction. This DNA could serve as an adjuvant to activate innate immunity as well as an immunogen to drive an antigen-specific antibody response. In this scenario, the generation of cross-reactive autoantibodies, in contrast to highly specific antibodies to bacterial DNA, most likely depends on genetically determined abnormalities in the B-cell repertoire in patients with SLE. Given the universal expression of DNA, this model suggests that many different kinds of infections could trigger pathogenic autoantibody responses in SLE, as well as induce flare. JF - Lupus AU - Pisetsky, D S AU - Vrabie, IA AD - Division of Rheumatology and Immunology, Duke University Medical Center, Durham, North Carolina, USA,, Medical Research Service, Durham Veterans Administration Medical Center, Durham, North Carolina, USA, piset001@mc.duke.edu Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 1176 EP - 1180 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 18 IS - 13 SN - 0961-2033, 0961-2033 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - anti-DNA KW - immune complexes KW - toll-like receptors KW - bacterial DNA KW - infection KW - genetics KW - Lymphocytes B KW - Antigen-antibody complexes KW - Animal models KW - Stimulants KW - Adjuvants KW - Immunity KW - Antibody response KW - Infection KW - Environmental factors KW - Inflammation KW - Interferon KW - Autoantibodies KW - Anti-DNA antibodies KW - DNA KW - Systemic lupus erythematosus KW - Toll-like receptors KW - Signal transduction KW - V 22350:Immunology KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02350:Immunology KW - N 14845:Miscellaneous KW - F 06930:Autoimmunity KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21488537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lupus&rft.atitle=Antibodies+to+DNA%3A+infection+or+genetics%3F&rft.au=Pisetsky%2C+D+S%3BVrabie%2C+IA&rft.aulast=Pisetsky&rft.aufirst=D&rft.date=2009-11-01&rft.volume=18&rft.issue=13&rft.spage=1176&rft.isbn=&rft.btitle=&rft.title=Lupus&rft.issn=09612033&rft_id=info:doi/10.1177%2F0961203309106492 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Lymphocytes B; Antigen-antibody complexes; Animal models; Stimulants; Antibody response; Immunity; Adjuvants; Infection; Environmental factors; Inflammation; Interferon; Autoantibodies; Anti-DNA antibodies; DNA; Systemic lupus erythematosus; Toll-like receptors; Signal transduction DO - http://dx.doi.org/10.1177/0961203309106492 ER - TY - JOUR T1 - Increased Low Density Lipoprotein and Increased Likelihood of Positive Prostate Biopsy in Black Americans AN - 21279875; 11179915 AB - Purpose - Differences in prostate cancer incidence, grade and stage at diagnosis, and survival in black vs nonblack men are well documented. Recent studies indicate that lipids may have a role in oncogenesis, including that of prostate cancer. We investigated the relationship between circulating lipids in black and nonblack patients, and newly diagnosed prostate cancer. Materials and Methods - The study population included consecutive patients who underwent prostate biopsy for increased prostate specific antigen and/or abnormal digital rectal examination at Atlanta Veterans Affairs Medical Center. Age, race, prostate specific antigen, prostate volume, body mass index, family history, high and low density lipoprotein, triglyceride and cholesterol lowering medications were included in data analysis. Results - A total of 1,775 men with complete information were included in data analysis. A total of 521 black and 451 white men had positive biopsies. Using 100 mg/dl or less as the referent the adjusted OR reflecting the association of low density lipoprotein and prostate cancer diagnosis in black men was 1.49 (95% CI 1.04-2.13, p = 0.031), 1.51 (95% CI 0.96-2.39, p = 0.076) and 3.24 (95% CI 1.59-6.92, p = 0.002) for low density lipoprotein greater than 100 to 130, greater than 130 to 160 and greater than 160 mg/dl, respectively. Corresponding results in nonblack men showed no significant association. Conclusions - Increased serum low density lipoprotein is associated with an increased likelihood of prostate cancer diagnosis in black men but not in nonblack men. This association is strongest in the highest low density lipoprotein risk category. The reasons for the racial differences are unknown but may include genetic, dietary or other environmental factors. JF - Journal of Urology AU - Moses, Kelvin A AU - Abd, Thura T AU - Goodman, Michael AU - Hsiao, Wayland AU - Hall, John A AU - Marshall, Fray F AU - Petros, John A AU - Issa, Muta M AD - Department of Urology, Atlanta Veterans Affairs Medical Center, Emory University School of Medicine, Emory University, Atlanta, Georgia, issa@med.va.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 2219 EP - 2225 PB - Elsevier Inc. VL - 182 IS - 5 SN - 0022-5347, 0022-5347 KW - Biotechnology and Bioengineering Abstracts KW - prostate KW - prostatic neoplasms KW - African Americans KW - cholesterol KW - LDL KW - risk KW - Age KW - Rectum KW - Data processing KW - Lipids KW - Tumorigenesis KW - Population studies KW - Survival KW - Biopsy KW - Cholesterol KW - Environmental factors KW - Prostate cancer KW - Risk factors KW - Triglycerides KW - Lipoproteins KW - Body mass index KW - Races KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21279875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Urology&rft.atitle=Increased+Low+Density+Lipoprotein+and+Increased+Likelihood+of+Positive+Prostate+Biopsy+in+Black+Americans&rft.au=Moses%2C+Kelvin+A%3BAbd%2C+Thura+T%3BGoodman%2C+Michael%3BHsiao%2C+Wayland%3BHall%2C+John+A%3BMarshall%2C+Fray+F%3BPetros%2C+John+A%3BIssa%2C+Muta+M&rft.aulast=Moses&rft.aufirst=Kelvin&rft.date=2009-11-01&rft.volume=182&rft.issue=5&rft.spage=2219&rft.isbn=&rft.btitle=&rft.title=Journal+of+Urology&rft.issn=00225347&rft_id=info:doi/10.1016%2Fj.juro.2009.07.039 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Rectum; Lipids; Tumorigenesis; Survival; Population studies; Biopsy; Cholesterol; Environmental factors; Prostate cancer; Triglycerides; Risk factors; Lipoproteins; Body mass index; Races DO - http://dx.doi.org/10.1016/j.juro.2009.07.039 ER - TY - JOUR T1 - Colorectal cancer screening mode preferences among US veterans AN - 21110832; 11267556 AB - Objective - To assess colorectal cancer (CRC) screening mode preferences and correlates of these preferences among US veterans at average risk for CRC. Method - A cross-sectional survey of a nationally representative sample of VA patients was conducted between January 2005 and December 2006. We report preference distributions for screening modes among 2068 average-risk veterans and across patient subgroups based on personal, behavioral, and environmental factors. Independent predictors of preferences are identified through hierarchical logistic regression models. Results - Colonoscopy (37%) was the most preferred mode followed by fecal occult blood test (FOBT) (29%). The strongest predictors of preferences were previous screening experience, provider recommendation, and use of non-VA healthcare services. Participants in higher socioeconomic groups were more likely to choose colonoscopy and less likely to indicate no preference. Conclusion - Screening programs that offer only one mode fail to accommodate the preferences of a substantial proportion of patients. Within the VA, adding screening colonoscopy to programs currently offering only FOBT is likely to increase preferences for colonoscopy, as patients incorporate provider recommendations for and personal experience with colonoscopy into their preferences. This is likely to disproportionately benefit lower socioeconomic groups who do not currently have access to non-VA colonoscopy services. JF - Preventive Medicine AU - Powell, Adam A AU - Burgess, Diana J AU - Vernon, Sally W AU - Griffin, Joan M AU - Grill, Joseph P AU - Noorbaloochi, Siamak AU - Partin, Melissa R AD - Center for Chronic Disease Outcomes Research (CCDOR), Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USA, Adam.Powell@va.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 442 EP - 448 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 49 IS - 5 SN - 0091-7435, 0091-7435 KW - Risk Abstracts KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21110832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=Colorectal+cancer+screening+mode+preferences+among+US+veterans&rft.au=Powell%2C+Adam+A%3BBurgess%2C+Diana+J%3BVernon%2C+Sally+W%3BGriffin%2C+Joan+M%3BGrill%2C+Joseph+P%3BNoorbaloochi%2C+Siamak%3BPartin%2C+Melissa+R&rft.aulast=Powell&rft.aufirst=Adam&rft.date=2009-11-01&rft.volume=49&rft.issue=5&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2009.09.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1016/j.ypmed.2009.09.002 ER - TY - JOUR T1 - Utilization of excimer laser debulking for critical lesions unsuitable for standard renal angioplasty AN - 1017964644; 16686276 AB - Background The energy emitted by ultraviolet laser is avidly absorbed in atherosclerotic plaques. Conceptually, it could be applied for debulking of selected atherosclerotic renal artery stenoses. We describe early experience with revascularization of critical renal artery lesions deemed unsuitable for standard renal angioplasty. Institutional Review Board permission to conduct the data analysis was obtained. Methods Among 130 percutaneous renal artery interventions with balloon angioplasty and adjunct stenting, there were 12 (9%) patients who underwent laser debulking prior to stenting. These patients presented with critical (95?3.5% stenoses) lesions (11 de novo, 1 stent restenosis) deemed unsuitable for standard renal angioplasty because of marked eccentricity and presence of thrombus. Indications for intervention included preservation of kidney function, treatment of uncontrolled hypertension, management of congestive heart failure, and treatment of unstable angina. Blood pressure and estimated glomerular filtration rate (eGFR) were measured pre- and 3 weeks post-intervention. Results A baseline angiographic stenosis of 95?3.5% was reduced to 50?13% with laser debulking. There were no laser-induced complications. Post-stenting the angiographic residual stenosis was 0%. The mean gradient across the lesions was reduced from baseline 85?40 to 0mmHg. A normal post-intervention antegrade renal flow was observed in all patients. Baseline mean systolic BP of 178?20mmHg decreased to 132?12mmHg (P<0.0001) and mean diastolic pressure of 85?16mmHg reduced to 71?9mmHg (P=0.01). A pre-intervention mean eGFR of 47.7?19ml/min/1.73m2 increased to 56?20.4ml/min/1.73m2 (P=0.05) post-procedure. The interventions were not associated with major renal or cardiac adverse events. During follow-up one patient developed transient contrast-induced nephropathy. Conclusions Debulking of select renal artery stenoses with laser angioplasty followed by adjunct stenting is feasible. Further prospective, randomized studies will be required to explore the role of debulking and laser angioplasty in renal artery revascularization. Lasers Surg. Med. 41:622-627, 2009. ? 2009 Wiley-Liss, Inc. JF - Lasers in Surgery and Medicine AU - Topaz, On AU - Polkampally, Pritam R AU - Topaz, Allyne AU - Polkampally, Chudamani R AU - Jara, Jessica AU - Rizk, Majid AU - McDowell, Kara AU - Feldman, George Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 622 EP - 627 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 41 IS - 9 SN - 1096-9101, 1096-9101 KW - Biotechnology and Bioengineering Abstracts KW - Arteriosclerosis KW - Blood pressure KW - Data processing KW - Early experience KW - Energy KW - Epidermal growth factor receptors KW - Glomerular filtration rate KW - Hypertension KW - Implants KW - Lasers KW - Nephropathy KW - Preservation KW - Renal artery KW - Renal function KW - Stenosis KW - Thrombosis KW - U.V. radiation KW - congestive heart failure KW - restenosis KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017964644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lasers+in+Surgery+and+Medicine&rft.atitle=Utilization+of+excimer+laser+debulking+for+critical+lesions+unsuitable+for+standard+renal+angioplasty&rft.au=Topaz%2C+On%3BPolkampally%2C+Pritam+R%3BTopaz%2C+Allyne%3BPolkampally%2C+Chudamani+R%3BJara%2C+Jessica%3BRizk%2C+Majid%3BMcDowell%2C+Kara%3BFeldman%2C+George&rft.aulast=Topaz&rft.aufirst=On&rft.date=2009-11-01&rft.volume=41&rft.issue=9&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Lasers+in+Surgery+and+Medicine&rft.issn=10969101&rft_id=info:doi/10.1002%2Flsm.20854 L2 - http://onlinelibrary.wiley.com/doi/10.1002/lsm.20854/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Data processing; Renal artery; restenosis; Epidermal growth factor receptors; Arteriosclerosis; Glomerular filtration rate; congestive heart failure; Thrombosis; Blood pressure; Early experience; U.V. radiation; Renal function; Energy; Implants; Nephropathy; Stenosis; Lasers; Preservation; Hypertension DO - http://dx.doi.org/10.1002/lsm.20854 ER - TY - CPAPER T1 - The Evidence-Based Practice Toolkit: Dissemination to VA Nurses Nation-Wide T2 - 40th Biennial Convention of the Honor Society of Nursing AN - 42575201; 5483782 JF - 40th Biennial Convention of the Honor Society of Nursing AU - Gerlock, April AU - Alt-White, Anna Y1 - 2009/10/31/ PY - 2009 DA - 2009 Oct 31 KW - Nursing KW - Medical personnel KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42575201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+Biennial+Convention+of+the+Honor+Society+of+Nursing&rft.atitle=The+Evidence-Based+Practice+Toolkit%3A+Dissemination+to+VA+Nurses+Nation-Wide&rft.au=Gerlock%2C+April%3BAlt-White%2C+Anna&rft.aulast=Gerlock&rft.aufirst=April&rft.date=2009-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+Biennial+Convention+of+the+Honor+Society+of+Nursing&rft.issn=&rft_id=info:doi/ L2 - http://stti.confex.com/stti/bc40/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cerebellar Purkinje cells incorporate immunoglobulins and immunotoxins in vitro: implications for human neurological disease and immunotherapeutics. AN - 734134879; 19874605 AB - Immunoglobulin G (IgG) antibodies reactive with intracellular neuronal proteins have been described in paraneoplastic and other autoimmune disorders. Because neurons have been thought impermeable to immunoglobulins, however, such antibodies have been considered unable to enter neurons and bind to their specific antigens during life. Cerebellar Purkinje cells - an important target in paraneoplastic and other autoimmune diseases - have been shown in experimental animals to incorporate a number of molecules from cerebrospinal fluid. IgG has also been detected in Purkinje cells studied post mortem. Despite the possible significance of these findings for human disease, immunoglobulin uptake by Purkinje cells has not been demonstrated in living tissue or studied systematically. To assess Purkinje cell uptake of immunoglobulins, organotypic cultures of rat cerebellum incubated with rat IgGs, human IgG, fluorescein-conjugated IgG, and rat IgM were studied by confocal microscopy in real time and following fixation. An IgG-daunorubicin immunotoxin was used to determine whether conjugation of pharmacological agents to IgG could be used to achieve Purkinje cell-specific drug delivery. IgG uptake was detected in Purkinje cell processes after 4 hours of incubation and in Purkinje cell cytoplasm and nuclei by 24-48 hours. Uptake could be followed in real time using IgG-fluorochrome conjugates. Purkinje cells also incorporated IgM. Intracellular immunoglobulin did not affect Purkinje cell viability, and Purkinje cells cleared intracellular IgG or IgM within 24-48 hours after transfer to media lacking immunoglobulins. The IgG-daunomycin immunotoxin was also rapidly incorporated into Purkinje cells and caused extensive, cell-specific death within 8 hours. Purkinje cell death was not produced by unconjugated daunorubicin or control IgG. Purkinje cells in rat organotypic cultures incorporate and clear host (rat) and non-host (human or donkey) IgG or IgM, independent of the immunoglobulin's reactivity with Purkinje cell antigens. This property permits real-time study of immunoglobulin-Purkinje cell interaction using fluorochrome IgG conjugates, and can allow Purkinje cell-specific delivery of IgG-conjugated pharmacological agents. Antibodies to intracellular Purkinje cell proteins could potentially be incorporated intracellularly to produce cell injury. Antibodies used therapeutically, including immunotoxins, may also be taken up and cause Purkinje cell injury, even if they do not recognize Purkinje cell antigens. JF - Journal of neuroinflammation AU - Hill, Kenneth E AU - Clawson, Susan A AU - Rose, John W AU - Carlson, Noel G AU - Greenlee, John E AD - Department of Neurology, University of Utah School of Medicine, 50 North Medical Drive Salt Lake City, UT 84132, USA. kenneth.hill2@va.gov Y1 - 2009/10/29/ PY - 2009 DA - 2009 Oct 29 SP - 31 VL - 6 KW - Antibiotics, Antineoplastic KW - 0 KW - Immunoglobulin G KW - Immunoglobulin M KW - Immunotoxins KW - Daunorubicin KW - ZS7284E0ZP KW - Index Medicus KW - Rats KW - Antibiotics, Antineoplastic -- metabolism KW - Animals KW - Rats, Sprague-Dawley KW - Cells, Cultured KW - Humans KW - Daunorubicin -- metabolism KW - Cerebellum -- cytology KW - Immunoglobulin M -- metabolism KW - Nervous System Diseases -- immunology KW - Immunotoxins -- metabolism KW - Immunoglobulin G -- metabolism KW - Purkinje Cells -- immunology KW - Purkinje Cells -- cytology KW - Immunotherapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734134879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroinflammation&rft.atitle=Cerebellar+Purkinje+cells+incorporate+immunoglobulins+and+immunotoxins+in+vitro%3A+implications+for+human+neurological+disease+and+immunotherapeutics.&rft.au=Hill%2C+Kenneth+E%3BClawson%2C+Susan+A%3BRose%2C+John+W%3BCarlson%2C+Noel+G%3BGreenlee%2C+John+E&rft.aulast=Hill&rft.aufirst=Kenneth&rft.date=2009-10-29&rft.volume=6&rft.issue=&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroinflammation&rft.issn=1742-2094&rft_id=info:doi/10.1186%2F1742-2094-6-31 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-04 N1 - Date created - 2009-11-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Chem Neuroanat. 1999 Sep;17(1):1-12 [10569235] Cytometry A. 2008 Dec;73A(12):1128-40 [18773464] J Neurol Sci. 2001 Mar 1;184(2):131-7 [11239946] J Neurol Sci. 2002 May 15;197(1-2):79-84 [11997071] Brain. 2003 Jun;126(Pt 6):1409-18 [12764061] Exp Cell Res. 1972 Sep;74(1):81-98 [4342186] Clin Exp Immunol. 1980 Jul;41(1):73-80 [7002392] Biochem Biophys Res Commun. 1981 Oct 15;102(3):1048-54 [7306187] Brain Res. 1981 Dec 28;230(1-2):307-16 [6119137] Ann Neurol. 1983 Dec;14(6):609-13 [6360029] Acta Histochem. 1984;74(1):11-9 [6428128] Science. 1985 Apr 19;228(4697):346-8 [2580350] Arch Neurol. 1985 Jul;42(7):690-4 [3925934] Dev Neurosci. 1985;7(3):133-60 [2866949] Science. 1986 Jan 10;231(4734):148-50 [3484557] J Neurol Sci. 1986 May;73(3):257-67 [3522806] J Cell Biol. 1986 Dec;103(6 Pt 1):2083-9 [3782292] Proc Natl Acad Sci U S A. 1987 Apr;84(8):2474-8 [3104916] Exp Neurol. 1987 Nov;98(2):453-7 [3666088] Parasitol Res. 1988;74(3):271-6 [3129718] J Neuropathol Exp Neurol. 1988 Sep;47(5):561-71 [3049946] Brain Res. 1989 Apr 3;483(2):379-83 [2706528] Brain Res. 1989 Dec 18;504(2):216-22 [2574621] Proc Natl Acad Sci U S A. 1990 Jul;87(13):5051-5 [2367523] J Neurol Sci. 1990 Aug;98(1):81-90 [2230832] Arch Ital Biol. 1990 Jul;128(2-4):127-49 [2268180] Bioconjug Chem. 1990 Jul-Aug;1(4):264-8 [2096919] J Clin Oncol. 1991 Dec;9(12):2095-103 [1960550] J Neurol Sci. 1991 Nov;106(1):82-7 [1779243] Cancer Res. 1992 Jun 1;52(11):3189-93 [1591729] Neurology. 1992 Oct;42(10):1931-7 [1407575] Lancet. 1993 Aug 7;342(8867):375-6 [8101621] Cancer Res. 1993 Aug 15;53(16):3752-7 [8339287] Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6591-5 [8393571] Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1128-32 [8302842] South Med J. 1994 Feb;87(2):263-4 [8115896] Acta Neuropathol. 1995;89(4):341-5 [7610765] Neuropathol Appl Neurobiol. 1996 Aug;22(4):361-9 [8875471] Eur J Neurosci. 1999 Jun;11(6):1927-36 [10336661] Methods Enzymol. 2005;393:418-35 [15817303] Brain Res Mol Brain Res. 2005 May 20;136(1-2):158-63 [15893600] Lancet Neurol. 2008 Apr;7(4):327-40 [18339348] Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8772-7 [18550843] Neuroscience. 2008 Jul 31;155(1):308-16 [18583062] J Immunol Methods. 2000 Sep 21;243(1-2):155-66 [10986413] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1742-2094-6-31 ER - TY - CPAPER T1 - Evaluation of the therapeutic use and monitoring of outpatient amiodarone therapy in a Veterans Administration population T2 - 2009 Annual Meeting of the American College of Clinical Pharmacy AN - 42102907; 5530201 JF - 2009 Annual Meeting of the American College of Clinical Pharmacy AU - Briegel, Erika AU - Allen, Arthur AU - Mambourg, Scott AU - Graettinger, William Y1 - 2009/10/18/ PY - 2009 DA - 2009 Oct 18 KW - Amiodarone KW - Environmental monitoring KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42102907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+American+College+of+Clinical+Pharmacy&rft.atitle=Evaluation+of+the+therapeutic+use+and+monitoring+of+outpatient+amiodarone+therapy+in+a+Veterans+Administration+population&rft.au=Briegel%2C+Erika%3BAllen%2C+Arthur%3BMambourg%2C+Scott%3BGraettinger%2C+William&rft.aulast=Briegel&rft.aufirst=Erika&rft.date=2009-10-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+American+College+of+Clinical+Pharmacy&rft.issn=&rft_id=info:doi/ L2 - http://www.accp.com/docs/meetings/am09/WednesdayPosters.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Patient and organizational factors related to education and support use by Veterans with Parkinson's disease. AN - 742784454; pmid-19606487 AB - Patient education and support services are recognized in the Department of Veterans Affairs (VA) as important to the patient-centered treatment of Parkinson's disease. Indeed, educating patients is one of the missions of the VA's six specialty Parkinson's Disease Research, Education and Clinical Centers (PADRECCs). We compared VA education/support services utilization by whether or not a patient's VA Medical Center (VAMC) contained a PADRECC. Our sample included Parkinson's disease patients from VAMCs with (n = 882) and without (n = 1,448) PADRECCs. Patients completed surveys that asked about demographic/individual characteristics, health status/function, and education/support utilization. Results showed that 15.8% (n = 354) of all patients utilized education/support services. Patients at PADRECC VAMCs were generally healthier and more educated than other VAMC patients. After statistically controlling for these differences, however, being a patient at a PADRECC VAMC site and using only VA providers (as compared to a combination of VA and non-VA providers) were significant predictors of education/support utilization. Further, proportionally more PADRECC VAMC site patients reported higher satisfaction and receiving a broad range of information from different modalities as compared to other VAMC patients. These findings suggest that PADRECC VAMCs are providing educational/support activities consistent with these specialty centers' goals. JF - Movement disorders : official journal of the Movement Disorder Society AU - Pogoda, Terri K AU - Cramer, Irene E AU - Meterko, Mark AU - Lin, Hai AU - Hendricks, Ann AU - Holloway, Robert G AU - Charns, Martin P AD - Center for Organization, Leadership and Management Research, Department of Veterans Affairs, 150 South Huntington Avenue (152M), Boston, MA 02130, USA. terri.pogoda@va.gov Y1 - 2009/10/15/ PY - 2009 DA - 2009 Oct 15 SP - 1916 EP - 1924 VL - 24 IS - 13 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Patient Education as Topic -- statistics & numerical data KW - United States KW - Young Adult KW - Patient Education as Topic -- methods KW - Chi-Square Distribution KW - Humans KW - Health Facilities -- utilization KW - Health Status KW - Retrospective Studies KW - Parkinson Disease -- complications KW - Aged KW - Hospitals, Veterans -- utilization KW - Hospitals, Veterans -- statistics & numerical data KW - Veterans KW - Patient Education as Topic -- organization & administration KW - Aged, 80 and over KW - Adult KW - Health Facilities -- organization & administration KW - Hospitals, Veterans -- organization & administration KW - Middle Aged KW - Parkinson Disease -- psychology KW - United States Department of Veterans Affairs -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742784454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Patient+and+organizational+factors+related+to+education+and+support+use+by+Veterans+with+Parkinson%27s+disease.&rft.au=Pogoda%2C+Terri+K%3BCramer%2C+Irene+E%3BMeterko%2C+Mark%3BLin%2C+Hai%3BHendricks%2C+Ann%3BHolloway%2C+Robert+G%3BCharns%2C+Martin+P&rft.aulast=Pogoda&rft.aufirst=Terri&rft.date=2009-10-15&rft.volume=24&rft.issue=13&rft.spage=1916&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Stem cell antigen-1+ cell-based bone morphogenetic protein-4 gene transfer strategy in mice failed to promote endosteal bone formation AN - 883029179; 15246498 AB - Background This study assessed whether a Sca-1+ cell-based ex vivo gene transfer strategy, which has been shown to promote robust endosteal bone formation with a modified fibroblast growth factor-2 (FGF2) gene, can be extended to use with bone morphogenetic protein (BMP)2/4 hybrid gene. Methods Sublethally irradiated recipient mice were transplanted with lentiviral (LV)-BMP2/4-transduced Sca-1+ cells. Bone parameters were monitored by pQCT and mu CT. Gene expression was assessed by the real-time reverse transcriptase-polymerase chain reaction. Results Recipient mice of LV-BMP2/4-transduced Sca-1+ cells yielded high engraftment and increased BMP4 mRNA levels in marrow cells; but exhibited only insignificant increases in serum and bone alkaline phosphatase activity compared to control mice. pQCT and mu CT analyses of femurs showed that, with the exception of small changes in trabecular bone mineral density and cortical bone mineral content in LV-BMP2/4 mice, there were no differences in measured bone parameters between mice of the LV-BMP2/4 group and controls. The lack of large endosteal bone formation effects with the BMP4 strategy could not be attributed to ineffective engraftment or expansion of BMP4-expressing Sca-1+ cells, an inability of the transduced cells to secrete active BMP4 proteins, or to use of the LV-based vector. Conclusions Sca-1+ cell-based BMP4 ex vivo strategy did not promote robust endosteal bone formation, raising the possibility of intrinsic differences between FGF2- and BMP4-based strategies in their ability to promote endosteal bone formation. It emphasizes the importance of choosing an appropriate bone growth factor gene for delivery by this Sca-1+ cell-based ex vivo systemic gene transfer strategy to promote bone formation. JF - Journal of Gene Medicine AU - Hall, Susan L AU - Chen, Shin-Tai AU - Gysin, Reinhard AU - Gridley, Daila S AU - Mohan, Subburaman AU - Lau, K-H William AD - Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA, USA, susan.hall1@va.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 877 EP - 888 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 11 IS - 10 SN - 1521-2254, 1521-2254 KW - Calcium & Calcified Tissue Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Alkaline phosphatase KW - Bone growth KW - Bone marrow KW - Bone mineral content KW - Bone mineral density KW - Bone morphogenetic protein 4 KW - Bone morphogenetic proteins KW - Computed tomography KW - Femur KW - Fibroblast growth factor 2 KW - Gene transfer KW - Hybrids KW - Osteogenesis KW - Polymerase chain reaction KW - Stem cells KW - T 2050:Genetics KW - G 07730:Development & Cell Cycle KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883029179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gene+Medicine&rft.atitle=Stem+cell+antigen-1%2B+cell-based+bone+morphogenetic+protein-4+gene+transfer+strategy+in+mice+failed+to+promote+endosteal+bone+formation&rft.au=Hall%2C+Susan+L%3BChen%2C+Shin-Tai%3BGysin%2C+Reinhard%3BGridley%2C+Daila+S%3BMohan%2C+Subburaman%3BLau%2C+K-H+William&rft.aulast=Hall&rft.aufirst=Susan&rft.date=2009-10-01&rft.volume=11&rft.issue=10&rft.spage=877&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gene+Medicine&rft.issn=15212254&rft_id=info:doi/10.1002%2Fjgm.1369 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jgm.1369/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Bone marrow; Bone growth; Femur; Stem cells; Bone morphogenetic proteins; Bone mineral density; Alkaline phosphatase; Gene transfer; Hybrids; Computed tomography; Bone mineral content; Polymerase chain reaction; Fibroblast growth factor 2; Bone morphogenetic protein 4; Osteogenesis DO - http://dx.doi.org/10.1002/jgm.1369 ER - TY - JOUR T1 - Historical perspective: Neurological advances from studies of war injuries and illnesses AN - 745926317; 12741522 AB - Early in the 20th century during the Russo-Japanese War and World War I (WWI), some of the most important, lasting contributions to clinical neurology were descriptive clinical studies, especially those concerning war-related peripheral nerve disorders (eg, Hoffmann-Tinel sign, Guillain-Barre-Strohl syndrome [GBS]) and occipital bullet wounds (eg, the retinal projection on the cortex by Inouye and later by Holmes and Lister, and the functional partitioning of visual processes in the occipital cortex by Riddoch), but there were also other important descriptive studies concerning war-related aphasia, cerebellar injuries, and spinal cord injuries (eg, cerebellar injuries by Holmes, and autonomic dysreflexia by Head and Riddoch). Later progress, during and shortly after World War II (WWII), included major progress in understanding the pathophysiology of traumatic brain injuries by Denny-Brown, Russell, and Holbourn, pioneering accident injury studies by Cairns and Holbourn, promulgation of helmets to prevent motorcycle injuries by Cairns, development of comprehensive multidisciplinary neurorehabilitation by Rusk, and development of spinal cord injury care by Munro, Guttman, and Bors. These studies and developments were possible only because of the large number of cases that allowed individual physicians the opportunity to collect, collate, and synthesize observations of numerous cases in a short span of time. Such studies also required dedicated, disciplined, and knowledgeable investigators who made the most out of their opportunities to systematically assess large numbers of seriously ill and injured soldiers under stressful and often overtly dangerous situations. Ann Neurol 2009; 66:444-459. JF - Annals of Neurology AU - Lanskaph, Douglas J AD - From the Department of Neurology, Veterans Affairs Medical Center, Tomah, WI, Douglas.Lanska@med.va.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 444 EP - 459 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 66 IS - 4 SN - 0364-5134, 0364-5134 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Autonomic nervous system KW - Retina KW - Rehabilitation KW - Head KW - Cortex (occipital) KW - Cerebellum KW - Spinal cord injury KW - Wounds KW - Accidents KW - Guillain-Barre syndrome KW - Cortex (visual) KW - War KW - Soldiers KW - Traumatic brain injury KW - aphasia KW - Peripheral nerves KW - Neurology KW - J 02310:Genetics & Taxonomy KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745926317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Neurology&rft.atitle=Historical+perspective%3A+Neurological+advances+from+studies+of+war+injuries+and+illnesses&rft.au=Lanskaph%2C+Douglas+J&rft.aulast=Lanskaph&rft.aufirst=Douglas&rft.date=2009-10-01&rft.volume=66&rft.issue=4&rft.spage=444&rft.isbn=&rft.btitle=&rft.title=Annals+of+Neurology&rft.issn=03645134&rft_id=info:doi/10.1002%2Fana.21822 L2 - http://www3.interscience.wiley.com/journal/122542892/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Autonomic nervous system; Head; Rehabilitation; Retina; Cortex (occipital); Cerebellum; Spinal cord injury; Wounds; Accidents; Guillain-Barre syndrome; War; Cortex (visual); Soldiers; aphasia; Traumatic brain injury; Peripheral nerves; Neurology DO - http://dx.doi.org/10.1002/ana.21822 ER - TY - JOUR T1 - Neuroprotective effect of testosterone treatment on motoneuron recruitment following the death of nearby motoneurons AN - 745728905; 13158108 AB - Motoneuron loss is a significant medical problem, capable of causing severe movement disorders or even death. We have previously shown that motoneuron death induces marked dendritic atrophy in surviving nearby motoneurons. Additionally, in quadriceps motoneurons, this atrophy is accompanied by decreases in motor nerve activity. However, treatment with testosterone partially attenuates changes in both the morphology and activation of quadriceps motoneurons. Testosterone has an even larger neuroprotective effect on the morphology of motoneurons of the spinal nucleus of the bulbocavernosus (SNB), in which testosterone treatment can completely prevent dendritic atrophy. The present experiment was performed to determine whether the greater neuroprotective effect of testosterone on SNB motoneuron morphology was accompanied by a greater neuroprotective effect on motor activation. Right side SNB motoneurons were killed by intramuscular injection of cholera toxin-conjugated saporin in adult male Sprague-Dawley rats. Animals were either given Silastic testosterone implants or left untreated. Four weeks later, left side SNB motor activation was assessed with peripheral nerve recording. The death of right side SNB motoneurons resulted in several changes in the electrophysiological response properties of surviving left side SNB motoneurons, including decreased background activity, increased response latency, increased activity duration, and decreased motoneuron recruitment. Treatment with exogenous testosterone attenuated the increase in activity duration and completely prevented the decrease in motoneuron recruitment. These data provide a functional correlate to the known protective effects of testosterone treatment on the morphology of these motoneurons, and further support a role for testosterone as a therapeutic agent in the injured nervous system. JF - Developmental Neurobiology AU - Fargo, Keith N AU - Foster, Allison M AU - Sengelaub, Dale R AD - Research and Development Service, Edward Hines, Jr. VA Hospital, Hines, Illinois 60141, keith.fargo@va.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 825 EP - 835 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 69 IS - 12 SN - 1932-8451, 1932-8451 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Data processing KW - Recruitment KW - Neuroprotection KW - spinal nucleus of the bulbocavernosus KW - Motor neurons KW - Nervous system KW - Testosterone KW - Movement disorders KW - saporin KW - Cholera KW - Atrophy KW - quadriceps muscle KW - Peripheral nerves KW - N3 11003:Developmental neuroscience KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745728905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Neurobiology&rft.atitle=Neuroprotective+effect+of+testosterone+treatment+on+motoneuron+recruitment+following+the+death+of+nearby+motoneurons&rft.au=Fargo%2C+Keith+N%3BFoster%2C+Allison+M%3BSengelaub%2C+Dale+R&rft.aulast=Fargo&rft.aufirst=Keith&rft.date=2009-10-01&rft.volume=69&rft.issue=12&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=Developmental+Neurobiology&rft.issn=19328451&rft_id=info:doi/10.1002%2Fdneu.20743 L2 - http://www3.interscience.wiley.com/journal/122538757/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Data processing; Recruitment; Neuroprotection; spinal nucleus of the bulbocavernosus; Motor neurons; Testosterone; Nervous system; Movement disorders; saporin; Atrophy; Cholera; quadriceps muscle; Peripheral nerves DO - http://dx.doi.org/10.1002/dneu.20743 ER - TY - JOUR T1 - Clinical foundation for efficient treatment of obstructive sleep apnea. AN - 742775733; pmid-19761911 AB - Only a few decades ago, the entity known as obstructive sleep apnea (OSA) was unknown and untreated. Now, there is a rush to put literally millions of Americans on continuous positive airway pressure devices. Community practice standards are changing yearly under pressure from strong forces based on economic incentives for industry, government, and physicians, independent of the actual medical evidence supporting treatment and efficacy. Medicare has lowered the diagnostic threshold for diagnosis and reimbursement; the International Classification of Sleep Disorders, Revision 2 (2005) has allowed OSA to be diagnosed exclusively by a laboratory test without the patient having clinical symptoms of excessive daytime sleepiness; and industry is poised to have the public buy computer-assisted continuous positive airway pressure machines without need of a physician prescription. Because of this paradigm shift away from physician-directed diagnosis and treatment, this article will critically evaluate the present state of medical evidence regarding the clinical foundation for treatment of OSA. JF - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons AU - Dasheiff, Richard M AU - Finn, Richard AD - Neurology and Sleep Medicine, Medical Service, Veterans Administration North Texas Health Care System, The University of Texas Southwestern Medical Center, Dallas, TX 75216, USA. Richard.Dasheiff@va.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 2171 EP - 2182 VL - 67 IS - 10 SN - 0278-2391, 0278-2391 KW - National Library of Medicine KW - Cardiovascular Diseases -- complications KW - Prescriptions KW - Health Services Needs and Demand KW - Evidence-Based Medicine KW - Humans KW - Snoring -- diagnosis KW - Quality of Life KW - Cause of Death KW - Risk Assessment KW - Hypertension -- complications KW - Polysomnography KW - Sleep Apnea, Obstructive -- therapy KW - Treatment Outcome KW - Snoring -- therapy KW - Disorders of Excessive Somnolence -- diagnosis KW - Sleep Apnea, Obstructive -- diagnosis KW - Clinical Protocols KW - Disorders of Excessive Somnolence -- therapy KW - Continuous Positive Airway Pressure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742775733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.atitle=Clinical+foundation+for+efficient+treatment+of+obstructive+sleep+apnea.&rft.au=Dasheiff%2C+Richard+M%3BFinn%2C+Richard&rft.aulast=Dasheiff&rft.aufirst=Richard&rft.date=2009-10-01&rft.volume=67&rft.issue=10&rft.spage=2171&rft.isbn=&rft.btitle=&rft.title=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.issn=02782391&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Chronic widespread pain, mental health, and physical role function in OEF/OIF veterans. AN - 734081658; 19818029 AB - Describe the associations among pain, mental health concerns, and function in veterans of Operation Enduring Freedom and Operation Iraqi Freedom (OEF/OIF). Retrospective review of self-reported, standardized clinical intake surveys. A multidisciplinary deployment health clinic at a Veterans Affairs (VA) medical center. The first 429 veterans of OEF/OIF presenting for clinical evaluation at a deployment health clinic. Function, measured with the Role Physical (RP) scale of the Veterans RAND (VR)-36 survey, was compared for veterans with and without chronic widespread pain (CWP). After controlling for age, sex, and positive screens for depression and post-traumatic stress disorder (PTSD), the presence of CWP had a significant, clinically relevant, and independent effect on VR-36 RP (-6.2 points, DeltaR(2) = 0.052, P < 0.001). Mean VR-36 RP normed score was 43.3 (standard deviation 11.9). CWP was common (29%), as were positive mental health screens (PTSD 53%, depression 60%, alcohol misuse 63%). In this sample of OEF/OIF veterans, the majority of whom reported good or better general health, CWP was common and related to poorer physical role function, independent of comorbid mental health concerns. JF - Pain medicine (Malden, Mass.) AU - Helmer, Drew A AU - Chandler, Helena K AU - Quigley, Karen S AU - Blatt, Melissa AU - Teichman, Ronald AU - Lange, Gudrun AD - Michael E DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX 77030, USA. drew.helmer@va.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1174 EP - 1182 VL - 10 IS - 7 KW - Index Medicus KW - Alcoholism -- epidemiology KW - Risk Factors KW - Humans KW - Adult KW - Incidence KW - Chronic Disease KW - Risk Assessment -- methods KW - United States -- epidemiology KW - Male KW - Female KW - Comorbidity KW - Veterans -- statistics & numerical data KW - Gulf War KW - Iraq War, 2003-2011 KW - Depression -- epidemiology KW - Mental Health -- statistics & numerical data KW - Pain -- epidemiology KW - Combat Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734081658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain+medicine+%28Malden%2C+Mass.%29&rft.atitle=Chronic+widespread+pain%2C+mental+health%2C+and+physical+role+function+in+OEF%2FOIF+veterans.&rft.au=Helmer%2C+Drew+A%3BChandler%2C+Helena+K%3BQuigley%2C+Karen+S%3BBlatt%2C+Melissa%3BTeichman%2C+Ronald%3BLange%2C+Gudrun&rft.aulast=Helmer&rft.aufirst=Drew&rft.date=2009-10-01&rft.volume=10&rft.issue=7&rft.spage=1174&rft.isbn=&rft.btitle=&rft.title=Pain+medicine+%28Malden%2C+Mass.%29&rft.issn=1526-4637&rft_id=info:doi/10.1111%2Fj.1526-4637.2009.00723.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-06 N1 - Date created - 2009-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1526-4637.2009.00723.x ER - TY - JOUR T1 - Following BMD in patients on bisphosphonates: another perspective. AN - 734048550; 19702482 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research AU - Adler, Robert A AU - Favus, Murray J AD - Endocrinology and Metabolism (111P), McGuire Veterans Affairs Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA. Robert.adler@va.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1647 EP - 1648 VL - 24 IS - 10 KW - Diphosphonates KW - 0 KW - Index Medicus KW - Medication Adherence KW - Humans KW - Clinical Trials as Topic KW - Absorptiometry, Photon KW - Male KW - Female KW - Diphosphonates -- therapeutic use KW - Diphosphonates -- adverse effects KW - Bone Density -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734048550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.atitle=Following+BMD+in+patients+on+bisphosphonates%3A+another+perspective.&rft.au=Adler%2C+Robert+A%3BFavus%2C+Murray+J&rft.aulast=Adler&rft.aufirst=Robert&rft.date=2009-10-01&rft.volume=24&rft.issue=10&rft.spage=1647&rft.isbn=&rft.btitle=&rft.title=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.issn=1523-4681&rft_id=info:doi/10.1359%2Fjbmr.090816 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-23 N1 - Date created - 2009-09-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: J Bone Miner Res. 2009 Oct;24(10):1643-6 [19712042] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1359/jbmr.090816 ER - TY - JOUR T1 - Military chemical warfare agent human subjects testing: part 1--history of six-decades of military experiments with chemical warfare agents. AN - 733598749; 19891215 AB - Military chemical warfare agent testing from World War I to 1975 produced thousands of veterans with concerns of possible long-term health consequences. Clinical and research evaluation of potential long-term health effects has been difficult because the exposures occurred decades ago, the identity of troops exposed and exposure magnitudes are uncertain, and acute effects during experiments poorly documented. In contrast, a companion article describes the large amount of information available about the specific agents tested and their long-term health effects. This short history describes U.S. military chemical-agent experiments with human subjects and identifies tested agents. Finally, the demonstrated need to anticipate future health concerns from military personnel involved in such military testing suggests current and future military researchers should be required, by law and regulation, to fully record the identity of those exposed, relevant exposure magnitude, and complete medical information for all subjects. New study protocols and institutional review board approvals for research involving military personnel should reflect this need. JF - Military medicine AU - Brown, Mark AD - Environmental Agents Service, U.S. Department of Veterans Affairs, 810 Vermont Avenue NW, Washington, DC 20420, USA. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1041 EP - 1048 VL - 174 IS - 10 SN - 0026-4075, 0026-4075 KW - Chemical Warfare Agents KW - 0 KW - Index Medicus KW - United States KW - History, 20th Century KW - Humans KW - Chemical Warfare Agents -- history KW - Human Experimentation -- history KW - Military Personnel -- history KW - Chemical Warfare -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733598749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=Military+chemical+warfare+agent+human+subjects+testing%3A+part+1--history+of+six-decades+of+military+experiments+with+chemical+warfare+agents.&rft.au=Brown%2C+Mark&rft.aulast=Brown&rft.aufirst=Mark&rft.date=2009-10-01&rft.volume=174&rft.issue=10&rft.spage=1041&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-23 N1 - Date created - 2009-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Military chemical warfare agent human subjects testing: part 2--long-term health effects among participants of U.S. military chemical warfare agent testing. AN - 733598341; 19891216 AB - Military chemical warfare agent testing from World War I to 1975 produced thousands of veterans with concerns about how their participation affected their health. A companion article describes the history of these experiments, and how the lack of clinical data hampers evaluation of long-term health consequences. Conversely, much information is available about specific agents tested and their long-term health effects in other populations, which may be invaluable for helping clinicians respond effectively to the health care and other needs of affected veterans. The following review describes tested agents and their known long-term health consequences. Although hundreds of chemicals were tested, they fall into only about a half-dozen pharmaceutical classes, including common pharmaceuticals; anticholinesterase agents including military nerve agents and pesticides; anticholinergic glycolic acid esters such as atropine; acetylcholine reactivators such as 2-PAM; psychoactive compounds including cannabinoids, phencyclidine, and LSD; and irritants including tear gas and riot control agents. JF - Military medicine AU - Brown, Mark AD - Environmental Agents Service, U.S. Department of Veterans Affairs, 810 Vermont Avenue NW, Washington, DC 20420, USA. Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1049 EP - 1054 VL - 174 IS - 10 SN - 0026-4075, 0026-4075 KW - Chemical Warfare Agents KW - 0 KW - Index Medicus KW - United States KW - History, 20th Century KW - Humans KW - Chemical Warfare Agents -- history KW - Military Personnel -- history KW - Chemical Warfare -- history KW - Chemical Warfare Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733598341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=Military+chemical+warfare+agent+human+subjects+testing%3A+part+2--long-term+health+effects+among+participants+of+U.S.+military+chemical+warfare+agent+testing.&rft.au=Brown%2C+Mark&rft.aulast=Brown&rft.aufirst=Mark&rft.date=2009-10-01&rft.volume=174&rft.issue=10&rft.spage=1049&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-23 N1 - Date created - 2009-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Routine work environment stress and PTSD symptoms in police officers. AN - 67690064; 19829204 AB - This study examined the relationship between routine work environment stress and posttraumatic stress disorder (PTSD) symptoms in a sample of police officers (N = 180) who were first assessed during academy training and reassessed 1-year later. In a model that included gender, ethnicity, traumatic exposure prior to entering the academy, current negative life events, and critical incident exposure over the last year, routine work environment stress was most strongly associated with PTSD symptoms. We also found that routine work environment stress mediated the relationship between critical incident exposure and PTSD symptoms and between current negative life events and PTSD symptoms. Ensuring that the work environment is functioning optimally protects against the effects of duty-related critical incidents and negative life events outside police service. JF - The Journal of nervous and mental disease AU - Maguen, Shira AU - Metzler, Thomas J AU - McCaslin, Shannon E AU - Inslicht, Sabra S AU - Henn-Haase, Clare AU - Neylan, Thomas C AU - Marmar, Charles R AD - San Francisco VA Medical Center, San Francisco, CA, USA. Shira.Maguen@va.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 754 EP - 760 VL - 197 IS - 10 KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Humans KW - Personality Inventory KW - Longitudinal Studies KW - Psychometrics KW - Mental Disorders -- diagnosis KW - Prospective Studies KW - Psychiatric Status Rating Scales KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - History, Ancient KW - Urban Population KW - Female KW - Male KW - Workplace -- psychology KW - Occupational Diseases -- diagnosis KW - Police -- statistics & numerical data KW - Stress Disorders, Post-Traumatic -- psychology KW - Life Change Events KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Stress, Psychological -- diagnosis KW - Occupational Diseases -- psychology KW - Stress, Psychological -- epidemiology KW - Workplace -- statistics & numerical data KW - Stress, Psychological -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67690064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=Routine+work+environment+stress+and+PTSD+symptoms+in+police+officers.&rft.au=Maguen%2C+Shira%3BMetzler%2C+Thomas+J%3BMcCaslin%2C+Shannon+E%3BInslicht%2C+Sabra+S%3BHenn-Haase%2C+Clare%3BNeylan%2C+Thomas+C%3BMarmar%2C+Charles+R&rft.aulast=Maguen&rft.aufirst=Shira&rft.date=2009-10-01&rft.volume=197&rft.issue=10&rft.spage=754&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=1539-736X&rft_id=info:doi/10.1097%2FNMD.0b013e3181b975f8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-29 N1 - Date created - 2009-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Consult Clin Psychol. 2000 Apr;68(2):290-5 [10780129] Mil Med. 2008 Jan;173(1):1-9 [18251325] Mil Med. 2004 Mar;169(3):198-206 [15080239] Mil Med. 2004 Jul;169(7):541-5 [15291187] J Consult Clin Psychol. 1978 Oct;46(5):932-46 [701572] J Consult Clin Psychol. 1988 Feb;56(1):85-90 [3346454] J Abnorm Psychol. 1995 Feb;104(1):184-95 [7897042] J Consult Clin Psychol. 1995 Jun;63(3):361-8 [7608348] J Trauma Stress. 1996 Jan;9(1):63-85 [8750452] J Nerv Ment Dis. 1997 Aug;185(8):498-506 [9284863] Psychol Rep. 1997 Dec;81(3 Pt 1):835-45 [9400075] J Pers Soc Psychol. 1998 Feb;74(2):420-34 [9491585] J Occup Health Psychol. 1996 Apr;1(2):224-35 [9547048] Mil Med. 1998 Jul;163(7):466-70 [9695612] Mil Med. 1998 Sep;163(9):587-93 [9753982] J Occup Health Psychol. 1998 Oct;3(4):368-89 [9805282] J Abnorm Psychol. 1999 Feb;108(1):164-70 [10067002] Biol Psychiatry. 2005 Jan 1;57(1):27-32 [15607297] Emerg Med J. 2006 Mar;23(3):226-31 [16498167] J Nerv Ment Dis. 2006 Aug;194(8):591-7 [16909067] J Affect Disord. 2007 Jan;97(1-3):241-5 [16859752] J Abnorm Psychol. 2007 May;116(2):352-61 [17516767] Occup Med (Lond). 2003 Jun;53(4):256-64 [12815123] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/NMD.0b013e3181b975f8 ER - TY - JOUR T1 - Commentary: Physician Retirement and Physician Shortages AN - 58829681; 2008-409630 AB - Considerable recent discussion has taken place regarding the predicted future shortage of physicians, especially in primary care. Much of the attention has focused on the difficulty of recruiting new physicians into primary care practice. It is suggested that part of the solution may be increased efforts to recruit and retain older physicians into primary care practice rather than retirement. Adapted from the source document. JF - Journal of Community Health AU - Nusbaum, Neil J AD - VA North Texas Health Care System, Dallas, TX 75216, USA NeilJ.Nusbaum@va.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 353 EP - 356 PB - Springer, New York NY VL - 34 IS - 5 SN - 0094-5145, 0094-5145 KW - Health conditions and policy - Physicians, nurses, and other health personnel KW - Labor conditions and policy - Employment and labor supply KW - Economic conditions and policy - Economic theory KW - Human capital KW - Physicians KW - Retirement KW - Supply and demand KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58829681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Commentary%3A+Physician+Retirement+and+Physician+Shortages&rft.au=Nusbaum%2C+Neil+J&rft.aulast=Nusbaum&rft.aufirst=Neil&rft.date=2009-10-01&rft.volume=34&rft.issue=5&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-009-9165-5 LA - English DB - PAIS Index N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - CODEN - JCMHBR N1 - SubjectsTermNotLitGenreText - Physicians; Supply and demand; Human capital; Retirement DO - http://dx.doi.org/10.1007/s10900-009-9165-5 ER - TY - JOUR T1 - Measuring Return on Investment in VA Libraries AN - 57702223; 201001340 AB - After evaluating available library-targeted return on investment (ROI) tools, VA Library Network Librarians created a workgroup to formulate a tool geared specifically to the Department of Veterans Affairs (VA) hospital libraries. The workgroup devised an approach with three separate components: a Return on Investment Analysistool that each library could employ a Library Scorecard that provided local and national examples of typical benefits, for libraries that could not devote time to using the ROI instrument and a Management Support Report for libraries that wanted a mission-based document to use with their local management. The tools were essentially complete in 18 months, after numerous drafts. Adapted from the source document. JF - Journal of Hospital Librarianship AU - Jemison, Karen AU - Poletti, Ed AU - Schneider, Janet AU - Clark, Nancy AU - Stone, Ron Drew AD - VA Palo Alto Health Care System, Library (142D), 3801 Miranda Ave., Palo Alto, CA 94304, USA karen.jemison@va.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 379 EP - 390 PB - Taylor & Francis, Philadelphia PA VL - 9 IS - 4 SN - 1532-3269, 1532-3269 KW - Measurement tools, return on investment, ROI, scorecard KW - Valuation KW - Hospital libraries KW - Investment KW - article KW - 6.12: FINANCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57702223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hospital+Librarianship&rft.atitle=Measuring+Return+on+Investment+in+VA+Libraries&rft.au=Jemison%2C+Karen%3BPoletti%2C+Ed%3BSchneider%2C+Janet%3BClark%2C+Nancy%3BStone%2C+Ron+Drew&rft.aulast=Jemison&rft.aufirst=Karen&rft.date=2009-10-01&rft.volume=9&rft.issue=4&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hospital+Librarianship&rft.issn=15323269&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2010-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Valuation; Investment; Hospital libraries ER - TY - JOUR T1 - Influenza A (H1N1) Virus (Swine Influenza): A Webliography AN - 57700279; 201002536 AB - In March and April 2009, a new strain of the virus that causes influenza in swine was identified in Mexico and the United States. This variant, known as influenza A (H1N1), was found to be transmitted from swine to humans and was called "swine flu" by the general public. Within days, the World Health Organization determined that the outbreak was spreading to many other countries and could become a pandemic. The differences between the response to this threat and those of the pandemics in 1918, 1957, and 1968 are impressive. Governments and organizations are better prepared to meet the challenges presented by the present swine influenza pandemic, putting into place measures developed in response to earlier pandemics. The virus itself causes symptoms similar to those of seasonal influenza, and the treatment is comparable. As of August 2009, a vaccine for H1N1 Influenza is still in development, with government and pharmaceutical manufacturers promising delivery in the fall of 2009. Two of the four anti-viral drugs currently in use in the United States for treatment of influenza are effective when used as a prophylactic and can reduce the severity of the flu symptoms if taken within 24 hours after symptoms appear. One of the striking developments of this health crisis has been the use of the Internet and various social media tools to provide information on swine flu. Scientists, government organizations, and public health agencies have all utilized new social media resources to keep professional colleagues, government and other agencies, and the general public informed. Information on the Internet allows consumers and their health providers to be well informed about current progress in preventing the spread of swine flu. Adapted from the source document. JF - Journal of Consumer Health on the Internet AU - Taylor, Mary Virginia AU - Stephenson, Priscilla L AD - VA Medical Center at Memphis, 1030 Jefferson Avenue, Memphis, TN 38104 maryvirginia.taylor@va.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 374 EP - 385 PB - Taylor & Francis, Philadelphia PA VL - 13 IS - 4 SN - 1539-8285, 1539-8285 KW - H1N1 subtype, influenza, influenza A virus, pandemic, swine flu, swine influenza KW - Web sites KW - Diseases KW - Consumer health information KW - article KW - 10.14: INFORMATION SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57700279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consumer+Health+on+the+Internet&rft.atitle=Influenza+A+%28H1N1%29+Virus+%28Swine+Influenza%29%3A+A+Webliography&rft.au=Taylor%2C+Mary+Virginia%3BStephenson%2C+Priscilla+L&rft.aulast=Taylor&rft.aufirst=Mary&rft.date=2009-10-01&rft.volume=13&rft.issue=4&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consumer+Health+on+the+Internet&rft.issn=15398285&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2010-03-05 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Consumer health information; Diseases; Web sites ER - TY - JOUR T1 - From Trauma to PTSD: Beliefs About Sensations, Symptoms, and Mental Illness AN - 57327454; 201001147 AB - Despite the ongoing debate about its legitimacy as a diagnostic entity, posttraumatic stress disorder (PTSD) continues to be the prevailing model for posttrauma suffering in Western societies. In this article, we examine how U.S. veterans came to conceptualize their posttrauma suffering as reflecting the mental disorder of PTSD. We describe the criteria veterans used to evaluate the potential clinical importance of their posttrauma reactions, and the process by which they came to label these reactions as PTSD. Difficulties that veterans experienced in evaluating their posttrauma reactions and in labeling them as PTSD mirror issues that have been raised about the diagnosis of PTSD in the professional literature. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Qualitative Health Research AU - Spoont, Michele R AU - Sayer, Nina AU - Friedemann-Sanchez, Greta AU - Parker, Louise E AU - Murdoch, Maureen AU - Chiros, Christine AD - Veterans Affairs Medical Center, Minneapolis, Minnesota, USA michele.spoont@med.va.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1456 EP - 1465 PB - Sage Publications, Thousand Oaks CA VL - 19 IS - 10 SN - 1049-7323, 1049-7323 KW - illness and disease experiences mental health and illness posttraumatic stress disorder (PTSD) trauma KW - Suffering KW - Veterans KW - Mental illness KW - Diagnosis KW - Posttraumatic stress disorder KW - Legitimacy KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57327454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Qualitative+Health+Research&rft.atitle=From+Trauma+to+PTSD%3A+Beliefs+About+Sensations%2C+Symptoms%2C+and+Mental+Illness&rft.au=Spoont%2C+Michele+R%3BSayer%2C+Nina%3BFriedemann-Sanchez%2C+Greta%3BParker%2C+Louise+E%3BMurdoch%2C+Maureen%3BChiros%2C+Christine&rft.aulast=Spoont&rft.aufirst=Michele&rft.date=2009-10-01&rft.volume=19&rft.issue=10&rft.spage=1456&rft.isbn=&rft.btitle=&rft.title=Qualitative+Health+Research&rft.issn=10497323&rft_id=info:doi/10.1177%2F1049732309348370 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - QHREEM N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Veterans; Suffering; Mental illness; Diagnosis; Legitimacy DO - http://dx.doi.org/10.1177/1049732309348370 ER - TY - JOUR T1 - Equivalence of two healthcare costing methods: bottom-up and top-down AN - 57309976; 200928232 AB - This paper compares two quite different approaches to estimating costs: a bottom-up approach, represented by the US Department of Veterans Affairs' (VA) Decision Support System that uses local costs of specific inputs; and a top-down approach, represented by the costing system created by the VA Health Economics Resource Center, which assigns the VA national healthcare budget to specific products using various weighting systems. Total annual costs per patient plus the cost for specific services (e.g. clinic visit, radiograph, laboratory, inpatient admission) were compared using scatterplots, correlations, mean difference, and standard deviation of individual differences. Analysis are based upon 2001 costs for 14 915 patients at 72 facilities. Correlations ranged from 0.24 for the cost of outpatient encounters to 0.77 for the cost of inpatient admissions, and 0.85 for total annual cost. The mean difference between costing methods was $707 ($4168 versus $3461) for total annual cost. The standard deviation of the individual differences was $5934. Overall, the agreement between the two costing systems varied by the specific cost being measured and increased with aggregation. Administrators and researchers conducting cost analyses need to carefully consider the purpose, methods, characteristics, strengths, and weaknesses when selecting a method for assessing cost. [Copyright John Wiley and Sons, Ltd.] JF - Health Economics AU - Chapko, Michael K AU - Liu, Chuan-Fen AU - Perkins, Mark AU - Li, Yu-Fang AU - Fortney, John C AU - Maciejewski, Matthew L AD - Health Services Research and Development, VA Puget Sound Health Care System, Seattle, WA, USA michael.chapko@va.gov Y1 - 2009/10// PY - 2009 DA - October 2009 SP - 1188 EP - 1201 PB - John Wiley, Chichester UK VL - 18 IS - 10 SN - 1057-9230, 1057-9230 KW - Health costs KW - Individual differences KW - Health care KW - Hospitalization KW - Costing systems KW - Deviation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57309976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=Equivalence+of+two+healthcare+costing+methods%3A+bottom-up+and+top-down&rft.au=Chapko%2C+Michael+K%3BLiu%2C+Chuan-Fen%3BPerkins%2C+Mark%3BLi%2C+Yu-Fang%3BFortney%2C+John+C%3BMaciejewski%2C+Matthew+L&rft.aulast=Chapko&rft.aufirst=Michael&rft.date=2009-10-01&rft.volume=18&rft.issue=10&rft.spage=1188&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.1422 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - HEECEZ N1 - SubjectsTermNotLitGenreText - Health costs; Deviation; Costing systems; Hospitalization; Health care; Individual differences DO - http://dx.doi.org/10.1002/hec.1422 ER - TY - JOUR T1 - ACHN-490, a Neoglycoside with Potent In Vitro Activity against Multidrug-Resistant Klebsiella pneumoniae Isolates AN - 21480431; 12492353 AB - The in vitro activity of ACHN-490, a novel aminoglycoside (QUOTATION_MARKneoglycosideQUOTATION_MARK), was evaluated against 102 multidrug-resistant (MDR) Klebsiella pneumoniae strains, including a subset of 25 strains producing the KPC carbapenemase. MIC50 values for gentamicin, tobramycin, and amikacin were 8 kg/ml, 32 kg/ml, and 2 kg/ml, respectively; MIC90 values for the same antimicrobials were 64 kg/ml, 64 kg/ml, and 32 kg/ml, respectively. ACHN-490 showed an MIC50 of 0.5 kg/ml and an MIC90 of 1 kg/ml, which are significantly lower than those of comparator aminoglycosides. ACHN-490 represents a promising aminoglycoside for the treatment of MDR K. pneumoniae isolates, including those producing KPC ?-lactamase. JF - Antimicrobial Agents & Chemotherapy AU - Endimiani, Andrea AU - Hujer, Kristine M AU - Hujer, Andrea M AU - Armstrong, Eliana S AU - Choudhary, Yuvraj AU - Aggen, James B AU - Bonomo, Robert A AD - Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, robert.bonomo@va.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 4504 EP - 4507 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 53 IS - 10 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Gentamicin KW - Tobramycin KW - Amikacin KW - Drug resistance KW - carbapenemase KW - Aminoglycoside antibiotics KW - Klebsiella pneumoniae KW - Antimicrobial agents KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21480431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=ACHN-490%2C+a+Neoglycoside+with+Potent+In+Vitro+Activity+against+Multidrug-Resistant+Klebsiella+pneumoniae+Isolates&rft.au=Endimiani%2C+Andrea%3BHujer%2C+Kristine+M%3BHujer%2C+Andrea+M%3BArmstrong%2C+Eliana+S%3BChoudhary%2C+Yuvraj%3BAggen%2C+James+B%3BBonomo%2C+Robert+A&rft.aulast=Endimiani&rft.aufirst=Andrea&rft.date=2009-10-01&rft.volume=53&rft.issue=10&rft.spage=4504&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00556-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Gentamicin; Amikacin; Tobramycin; Drug resistance; carbapenemase; Aminoglycoside antibiotics; Antimicrobial agents; Klebsiella pneumoniae DO - http://dx.doi.org/10.1128/AAC.00556-09 ER - TY - JOUR T1 - Site and Clinical Significance of Alloscardovia omnicolens and Bifidobacterium Species Isolated in the Clinical Laboratory AN - 21281028; 12511505 AB - Most of the members of the genus Bifidobacterium, including the related organism Alloscardovia omnicolens, are inhabitants of the gastrointestinal tract and oral cavity of humans and animals and have been considered nonpathogenic for humans. However, the actual site of isolation and the clinical significance of A. omnicolens and of Bifidobacterium species are unclear. This may be due in part to the difficulties in distinguishing these organisms from other genera such as Actinomyces. To determine the potential disease-causing role of these organisms, we analyzed the clinical significance of 15 A. omnicolens and Bifidobacterium isolates identified by 16S rRNA gene sequencing from a clinical laboratory. All of the organisms in this study were isolated from sterile sites or in significant numbers by standard clinical microbiological culture methods. Our 15 clinical strains fit into only four species: A. omnicolens (five isolates), Bifidobacterium scardovii (four isolates), B. longum (two isolates), and B. breve (four isolates). All five A. omnicolens isolates, one of the B. breve isolates, and three of the four B. scardovii isolates were cultured from urine at 105 CFU/ml. One B. scardovii isolate was from a patient with a genitourinary tract wound infection, two B. longum isolates were from abdominal wounds, and three B. breve isolates were from blood cultures. This study enlarges the spectrum of diseases and clinical sources associated with A. omnicolens and Bifidobacterium species and addresses identification problems. JF - Journal of Clinical Microbiology AU - Mahlen, Steven D AU - Clarridge III, Jill E AD - U.S. Army Medical Corps with duty at the Department of Laboratory Medicine, University of Washington, Seattle, Washington, jill.clarridge@va.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 3289 EP - 3293 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 47 IS - 10 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Blood culture KW - Urine KW - Wound infection KW - Colony-forming cells KW - Genitourinary tract KW - Gastrointestinal tract KW - rRNA 16S KW - Actinomyces KW - Oral cavity KW - Bifidobacterium KW - Wounds KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21281028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Site+and+Clinical+Significance+of+Alloscardovia+omnicolens+and+Bifidobacterium+Species+Isolated+in+the+Clinical+Laboratory&rft.au=Mahlen%2C+Steven+D%3BClarridge+III%2C+Jill+E&rft.aulast=Mahlen&rft.aufirst=Steven&rft.date=2009-10-01&rft.volume=47&rft.issue=10&rft.spage=3289&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00555-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Blood culture; Wound infection; Urine; Colony-forming cells; Genitourinary tract; Gastrointestinal tract; rRNA 16S; Oral cavity; Wounds; Actinomyces; Bifidobacterium DO - http://dx.doi.org/10.1128/JCM.00555-09 ER - TY - JOUR T1 - The Carpometacarpal Stress View Radiograph in the Evaluation of Trapeziometacarpal Joint Laxity AN - 21243414; 11268145 AB - Purpose - Hypermobility at the thumb carpometacarpal (CMC) joint has been proposed as an explanation for abnormal loading and subsequent development of osteoarthritis. Radiographic evaluation of this joint is difficult owing to the obliquity of the articulation. We modified a previously described technique to obtain a bilateral stress radiograph of the thumbs to measure CMC joint laxity. The purpose of this study was to present the details of this modified technique and evaluate its reproducibility in a group of volunteer subjects. We hypothesized that this technique would be reliable and reproducible. Methods - A posteroanterior radiograph was obtained after asking volunteer subjects to press their thumbs together using a foam hand support. Three measurements were performed: radial subluxation of the first metacarpal base, first metacarpal articular width, and the distance between the ulnar articular facet of the trapezium and the ulnar metacarpal edge (uncovered edge). Using digital calibration on a picture archiving and communication system radiology server, a radiologist, radiology resident, orthopedic surgeon, and orthopedic resident performed measurements at 2 time points. To evaluate consistency among the raters, intraclass correlation coefficients were calculated. Test-retest bivariate analyses were performed to assess intra- rater reliability. Results - A total of 69 volunteers (39 women and 30 men) were imaged. Women showed significantly greater radial subluxation compared to men (p < .01). Inter-rater reliability coefficients for radial subluxation and articular width initially and at 2 weeks showed high agreement, as did test-retest reliability coefficients. For the uncovered edge measurement, inter-rater reliability coefficients were low, with wide variation in reliability. Conclusions - The modified thumb CMC stress view radiograph evaluates laxity and joint abnormalities of the trapeziometacarpal articulation. The details of the radiographic technique are straightforward, and the inter- and intra-observer reliability of radial subluxation and first metacarpal width are high. The ratio of the 2 measurements provides an accurate measure of the radiographic subluxation of the first metacarpal from the trapezium. This measurement is most specific to radial subluxation under simulated active loading, in the plane of the hand. The medial uncovered edge of trapezium measurement does not have high inter-observer reliability and varies widely, and it should not be included in laxity measurements. JF - Journal of Hand Surgery (American Volume) AU - Wolf, Jennifer Moriatis AU - Oren, Trevor W AU - Ferguson, Bradley AU - Williams, Allison AU - Petersen, Brian AD - Department of Orthopaedic Surgery, University of Colorado - Denver, Aurora, CO; Department of Radiology, University of Colorado-Denver, Aurora, CO; Department of Nursing Service/Research, Denver Veterans Administration Medical Center, Denver, CO, Jennifer.Wolf@ucdenver.edu Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 1402 EP - 1406 PB - Churchill Livingstone, Robert Stevenson House Edinburgh EH1 3AF UK VL - 34 IS - 8 SN - 0363-5023, 0363-5023 KW - Health & Safety Science Abstracts KW - Communications KW - Trapezium KW - Stress KW - Radiology KW - surgery KW - Medical personnel KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21243414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hand+Surgery+%28American+Volume%29&rft.atitle=The+Carpometacarpal+Stress+View+Radiograph+in+the+Evaluation+of+Trapeziometacarpal+Joint+Laxity&rft.au=Wolf%2C+Jennifer+Moriatis%3BOren%2C+Trevor+W%3BFerguson%2C+Bradley%3BWilliams%2C+Allison%3BPetersen%2C+Brian&rft.aulast=Wolf&rft.aufirst=Jennifer&rft.date=2009-10-01&rft.volume=34&rft.issue=8&rft.spage=1402&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hand+Surgery+%28American+Volume%29&rft.issn=03635023&rft_id=info:doi/10.1016%2Fj.jhsa.2009.06.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Communications; Stress; Radiology; Medical personnel; surgery; Trapezium DO - http://dx.doi.org/10.1016/j.jhsa.2009.06.030 ER - TY - JOUR T1 - Is the Use of Low-Pressure Pulsatile Lavage for Pressure Ulcer Management Associated With Environmental Contamination With Acinetobacter baumannii? AN - 21184653; 11268545 AB - Ho CH, Johnson T, Miklacic J, Donskey CJ. Is the use of low-pressure pulsatile lavage for pressure ulcer management associated with environmental contamination with Acinetobacter baumannii? Objective - To determine the extent of environmental contamination associated with low-pressure pulsatile lavage of stage III or IV pressure ulcers in patients with spinal cord injury (SCI) when routine infection control precautions are used for wounds colonized or infected with Acinetobacter baumannii. Design - Prospective investigation in which pressure ulcer cultures and environmental cultures were obtained before and after low-pressure pulsatile lavage treatment, and before and after regular dressing changes. Environmental cultures included the patient's bedrail and settle plates placed 0.6, 1.5, and 2.4m from the wound to assess airborne spread of A. baumannii. Setting - SCI inpatient unit in a Department of Veterans Affairs Medical Center. Participants - Inpatients (N=15) with SCI receiving daily low-pressure pulsatile lavage treatment for stage III or IV pressure ulcers with standard dressing change, as well as regular dressing changes without low-pressure pulsatile lavage at other times of the day. Interventions - Standard, regular dressing changes and dressing changes with low-pressure pulsatile lavage. Main Outcome Measures - Comparison of frequency of environmental contamination with A. baumannii associated with low-pressure pulsatile lavage versus regular dressing changes. Results - Of the 15 SCI inpatients meeting inclusion criteria, 9 (60%) grew A. baumannii from their wounds. Of the 9 patients with wound cultures positive for A. baumannii, only 1 (11%) had environmental contamination with this organism after performance of low-pressure pulsatile lavage, and the same patient had environmental contamination after a standard dressing change. The antibiotic susceptibility patterns of the wound and environmental A. baumannii isolates were identical. Conclusions - Low-pressure pulsatile lavage using the infection control methods described is not associated with an increased rate of environmental contamination of A. baumannii in comparison with standard dressing changes. JF - Archives of Physical Medicine and Rehabilitation AU - Ho, Chester H AU - Johnson, Tova AU - Miklacic, Joan AU - Donskey, Curtis J AD - Spinal Cord Injury/Disorders Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, chester.ho@va.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 1723 EP - 1726 PB - Elsevier BV, The Curtis Center, Independence Square West Philadelphia PA 19106-3399 USA VL - 90 IS - 10 SN - 0003-9993, 0003-9993 KW - Microbiology Abstracts B: Bacteriology KW - Acinetobacter baumannii KW - Dressings KW - Contamination KW - Rehabilitation KW - Ulcers KW - Antibiotics KW - Spinal cord injury KW - Pressure KW - Infection KW - Wounds KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21184653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Is+the+Use+of+Low-Pressure+Pulsatile+Lavage+for+Pressure+Ulcer+Management+Associated+With+Environmental+Contamination+With+Acinetobacter+baumannii%3F&rft.au=Ho%2C+Chester+H%3BJohnson%2C+Tova%3BMiklacic%2C+Joan%3BDonskey%2C+Curtis+J&rft.aulast=Ho&rft.aufirst=Chester&rft.date=2009-10-01&rft.volume=90&rft.issue=10&rft.spage=1723&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/10.1016%2Fj.apmr.2009.04.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Dressings; Rehabilitation; Contamination; Ulcers; Antibiotics; Spinal cord injury; Infection; Pressure; Wounds; Acinetobacter baumannii DO - http://dx.doi.org/10.1016/j.apmr.2009.04.009 ER - TY - JOUR T1 - The clinical consequences of antimicrobial resistance AN - 21153598; 11183907 AB - The continued evolution of antimicrobial resistance in the hospital and more recently in the community threatens to seriously compromise our ability to treat serious infections. The major success of the seven- valent Streptococcus pneumoniae vaccine at reducing both infection and resistance has been followed by the emergence of previously minor serotypes that express multiresistance. The almost universal activity of cephalosporins and fluoroquinolones against community Escherichia coli strains has been compromised by the spread of CTX-M beta -lactamase-producing, fluoroquinolone-resistant strains, and the emergence of community-onset methicillin-resistant Staphylococcus aureus, particularly in the United States, has forced us to re-think our empirical treatment guidelines for skin and soft-tissue infections. Finally, our most potent and reliable class of antibiotics, the carbapenems, is compromised by the growth, primarily in intensive care units, of multiresistant Klebsiella pneumoniae, Acinetobacter baumanni, and Pseudomonas aeruginosa. The lack of a robust pipeline of new agents, particularly against resistant Gram-negative bacteria, emphasizes the importance of optimizing our use of current antimicrobials and promoting strict adherence to established infection control practices. JF - Current Opinion in Microbiology AU - Rice, Louis B AD - Medical Service 111(W), Louis Stokes Cleveland VA Medical Center, 10701 East Blvd., Cleveland, OH 44106, United States, louis.rice@va.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 476 EP - 481 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 12 IS - 5 SN - 1369-5274, 1369-5274 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Cephalosporins KW - Skin KW - Serotypes KW - Fluoroquinolones KW - Drug resistance KW - Carbapenems KW - Antibiotics KW - Infection KW - Antimicrobial agents KW - Streptococcus pneumoniae KW - Acinetobacter KW - Intensive care units KW - Reviews KW - Gram-negative bacteria KW - Escherichia coli KW - Vaccines KW - Pseudomonas aeruginosa KW - Staphylococcus aureus KW - Evolution KW - Klebsiella pneumoniae KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21153598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Microbiology&rft.atitle=The+clinical+consequences+of+antimicrobial+resistance&rft.au=Rice%2C+Louis+B&rft.aulast=Rice&rft.aufirst=Louis&rft.date=2009-10-01&rft.volume=12&rft.issue=5&rft.spage=476&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Microbiology&rft.issn=13695274&rft_id=info:doi/10.1016%2Fj.mib.2009.08.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cephalosporins; Serotypes; Skin; Fluoroquinolones; Drug resistance; Carbapenems; Antibiotics; Infection; Antimicrobial agents; Intensive care units; Gram-negative bacteria; Reviews; Vaccines; Evolution; Hospitals; Streptococcus pneumoniae; Acinetobacter; Escherichia coli; Staphylococcus aureus; Pseudomonas aeruginosa; Klebsiella pneumoniae DO - http://dx.doi.org/10.1016/j.mib.2009.08.001 ER - TY - JOUR T1 - Gene Expression Patterns Associated with Posttraumatic Stress Disorder Following Exposure to the World Trade Center Attacks AN - 21080119; 11071898 AB - Although genetic risk factors for posttraumatic stress disorder (PTSD) in similarly traumatized cohorts can be confounded with risk for type of exposure, the primary risk for exposure to the 9/11 attack on New York City was proximity, allowing study of PTSD risk in a sample that is not confounded by exposure-related risk. Methods - Thirty-five Caucasians (15 with PTSD, stratified for exposure, age, and gender) were selected from a population-representative sample of persons exposed to the attack from which longitudinal data had been collected in four previous waves. Whole blood gene expression and cortisol levels were obtained. Results - Seventeen probe sets were differentially expressed in PTSD. Identified genes were generally involved in hypothalamic-pituitary-adrenal (HPA) axis, signal transduction, or brain and immune cell function. FKBP5, a modulator of glucocorticoid receptor (GR) sensitivity, showed reduced expression in PTSD, consistent with enhanced GR responsiveness. FKBP5 expression was predicted by cortisol when entered with PTSD severity in regression analysis. Quantitative polymerase chain reaction confirmed significant reductions in FKBP5. Also less expressed in PTSD were STAT5B, a direct inhibitor of GR, and major histocompatibility complex (MHC) Class II. Conclusions - Consistent with observations of HPA axis dysfunction in PTSD, several genes involved in glucocorticoid signaling are differentially expressed among those with current PTSD. JF - Biological Psychiatry AU - Yehuda, Rachel AU - Cai, Guiqing AU - Golier, Julia A AU - Sarapas, Casey AU - Galea, Sandro AU - Ising, Marcus AU - Rein, Theo AU - Schmeidler, James AU - Mueller-Myhsok, Bertram AU - Holsboer, Florian AU - Buxbaum, Joseph D AD - Mount Sinai School of Medicine and James J. Peters Veterans Affairs Medical Center, Bronx, New York, rachel.yehuda@va.gov Y1 - 2009/10/01/ PY - 2009 DA - 2009 Oct 01 SP - 708 EP - 711 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 66 IS - 7 SN - 0006-3223, 0006-3223 KW - Toxicology Abstracts; Genetics Abstracts; CSA Neurosciences Abstracts KW - Age KW - Data processing KW - Hydrocortisone KW - Brain KW - Probes KW - Major histocompatibility complex KW - Hypothalamic-pituitary-adrenal axis KW - Glucocorticoids KW - Post-traumatic stress disorder KW - Gene expression KW - Blood KW - Glucocorticoid receptors KW - Risk factors KW - Regression analysis KW - Polymerase chain reaction KW - Signal transduction KW - X 24310:Pharmaceuticals KW - N3 11001:Behavioral and Cognitive Neuroscience KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21080119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Psychiatry&rft.atitle=Gene+Expression+Patterns+Associated+with+Posttraumatic+Stress+Disorder+Following+Exposure+to+the+World+Trade+Center+Attacks&rft.au=Yehuda%2C+Rachel%3BCai%2C+Guiqing%3BGolier%2C+Julia+A%3BSarapas%2C+Casey%3BGalea%2C+Sandro%3BIsing%2C+Marcus%3BRein%2C+Theo%3BSchmeidler%2C+James%3BMueller-Myhsok%2C+Bertram%3BHolsboer%2C+Florian%3BBuxbaum%2C+Joseph+D&rft.aulast=Yehuda&rft.aufirst=Rachel&rft.date=2009-10-01&rft.volume=66&rft.issue=7&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=Biological+Psychiatry&rft.issn=00063223&rft_id=info:doi/10.1016%2Fj.biopsych.2009.02.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Age; Hydrocortisone; Data processing; Probes; Brain; Major histocompatibility complex; Hypothalamic-pituitary-adrenal axis; Post-traumatic stress disorder; Glucocorticoids; Gene expression; Blood; Glucocorticoid receptors; Risk factors; Regression analysis; Polymerase chain reaction; Signal transduction DO - http://dx.doi.org/10.1016/j.biopsych.2009.02.034 ER - TY - JOUR T1 - A randomized trial comparing two models of web-based training in cognitive-behavioral therapy for substance abuse counselors AN - 21073961; 11085083 AB - This study compared training outcomes obtained by 147 substance abuse counselors who completed eight self-paced online modules on cognitive-behavioral therapy (CBT) and attended a series of four weekly group supervision sessions using Web conferencing software. Participants were randomly assigned to two conditions that systematically varied the degree to which they explicitly promoted adherence to the CBT protocol and the degree of control that they afforded participants over the sequence and relative emphasis of the training curriculum. Outcomes were assessed at baseline and immediately following training. Counselors in both conditions demonstrated similar improvements in CBT knowledge and self-efficacy. Counselors in the low- fidelity condition demonstrated greater improvement on one of three measures of job-related burnout when compared to the high-fidelity condition. The study concludes that it is feasible to implement a technology- based training intervention with a geographically diverse sample of practitioners, that two training conditions applied to these samples of real-world counselors do not produce statistically or clinically significant differences in knowledge or self-efficacy, and that further research is needed to evaluate how a flexible training model may influence clinician behavior and patient outcomes. JF - Journal of Substance Abuse Treatment AU - Weingardt, Kenneth R AU - Cucciare, Michael A AU - Bellotti, Christine AU - Lai, Wen Pin AD - Center for Health Care Evaluation, VA Palo Alto Health Care System and, Stanford University School of Medicine, Palo Alto, CA, USA, ken.weingardt@va.gov Y1 - 2009/10// PY - 2009 DA - Oct 2009 SP - 219 EP - 227 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 37 IS - 3 SN - 0740-5472, 0740-5472 KW - Health & Safety Science Abstracts KW - Web-based training KW - Cognitive-Behavioral therapy KW - Substance use disorder counselors KW - Blended learning KW - substance abuse KW - Computer programs KW - Training KW - intervention KW - burnout KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21073961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=A+randomized+trial+comparing+two+models+of+web-based+training+in+cognitive-behavioral+therapy+for+substance+abuse+counselors&rft.au=Weingardt%2C+Kenneth+R%3BCucciare%2C+Michael+A%3BBellotti%2C+Christine%3BLai%2C+Wen+Pin&rft.aulast=Weingardt&rft.aufirst=Kenneth&rft.date=2009-10-01&rft.volume=37&rft.issue=3&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/10.1016%2Fj.jsat.2009.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - substance abuse; Computer programs; Training; intervention; burnout; Occupational health DO - http://dx.doi.org/10.1016/j.jsat.2009.01.002 ER - TY - JOUR T1 - Online posting of unprofessional content by medical students. AN - 67669682; 19773566 AB - Web 2.0 applications, such as social networking sites, are creating new challenges for medical professionalism. The scope of this problem in undergraduate medical education is not well-defined. To assess the experience of US medical schools with online posting of unprofessional content by students and existing medical school policies to address online posting. An anonymous electronic survey was sent to deans of student affairs, their representatives, or counterparts from each institution in the Association of American Medical Colleges. Data were collected in March and April 2009. Percentage of schools reporting incidents of students posting unprofessional content online, type of professionalism infraction, disciplinary actions taken, existence of institution policies, and plans for policy development. Sixty percent of US medical schools responded (78/130). Of these schools, 60% (47/78) reported incidents of students posting unprofessional online content. Violations of patient confidentiality were reported by 13% (6/46). Student use of profanity (52%; 22/42), frankly discriminatory language (48%; 19/40), depiction of intoxication (39%; 17/44), and sexually suggestive material (38%; 16/42) were commonly reported. Of 45 schools that reported an incident and responded to the question about disciplinary actions, 30 gave informal warning (67%) and 3 reported student dismissal (7%). Policies that cover student-posted online content were reported by 38% (28/73) of deans. Of schools without such policies, 11% (5/46) were actively developing new policies to cover online content. Deans reporting incidents were significantly more likely to report having such a policy (51% vs 18%; P = .006), believing these issues could be effectively addressed (91% vs 63%; P = .003), and having higher levels of concern (P = .02). Many responding schools had incidents of unprofessional student online postings, but they may not have adequate policy in place. JF - JAMA AU - Chretien, Katherine C AU - Greysen, S Ryan AU - Chretien, Jean-Paul AU - Kind, Terry AD - Medical Service, Washington DC VA Medical Center and Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20422, USA. katherine.chretien@va.gov Y1 - 2009/09/23/ PY - 2009 DA - 2009 Sep 23 SP - 1309 EP - 1315 VL - 302 IS - 12 KW - Abridged Index Medicus KW - Index Medicus KW - Policy Making KW - Sex Offenses -- statistics & numerical data KW - Alcoholic Intoxication -- epidemiology KW - Humans KW - Confidentiality KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Substance-Related Disorders -- epidemiology KW - Students, Medical -- statistics & numerical data KW - Schools, Medical -- statistics & numerical data KW - Public Policy KW - Internet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67669682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Online+posting+of+unprofessional+content+by+medical+students.&rft.au=Chretien%2C+Katherine+C%3BGreysen%2C+S+Ryan%3BChretien%2C+Jean-Paul%3BKind%2C+Terry&rft.aulast=Chretien&rft.aufirst=Katherine&rft.date=2009-09-23&rft.volume=302&rft.issue=12&rft.spage=1309&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=1538-3598&rft_id=info:doi/10.1001%2Fjama.2009.1387 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-28 N1 - Date created - 2009-09-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 2010 Jan 27;303(4):328; author reply 329 [20103752] JAMA. 2010 Jan 27;303(4):328-9; author reply 329 [20103751] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/jama.2009.1387 ER - TY - JOUR T1 - Premature discharge from methadone treatment: patient perspectives. AN - 734190823; 19999682 AB - Longer retention in drug abuse treatment is associated with better patient outcomes, and research indicates the first 12 months of methadone treatment are critical to patient success. Nevertheless, large-scale multisite longitudinal studies over the past three decades indicate that the majority of patients drop out during the first year of methadone treatment. Through an examination of 42 qualitative interviews with patients prematurely discharged from six methadone treatment programs in Baltimore, this study highlights factors patients describe as contributing to their reasons for being discharged within the first 12 months of the treatment. The two most consistent themes are program-related factors and incarceration. The former factors are richly described through patients' words and underscore the ways in which patients' perceptions of control exerted by the program and by the medication and misunderstandings of program structure can lead to premature discharge. Patients' reasons for discharge were compared to counselors' reasons as indicated in discharge summary forms. An analysis of the patterns of agreement and disagreement are presented. Patient-centered program and policy implications are discussed. JF - Journal of psychoactive drugs AU - Reisinger, Heather Schacht AU - Schwartz, Robert P AU - Mitchell, Shannon Gwin AU - Peterson, James A AU - Kelly, Sharon M AU - O'Grady, Kevin E AU - Marrari, Erica A AU - Brown, Barry S AU - Agar, Michael H AD - Iowa City VA Medical Center, 601 Hwy 6 West, Iowa City, IA 52246, USA. heather.reisinger@va.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 285 EP - 296 VL - 41 IS - 3 SN - 0279-1072, 0279-1072 KW - Narcotics KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Discharge KW - Methadone treatment KW - Ethnography KW - Patient Satisfaction KW - Humans KW - Counseling KW - Longitudinal Studies KW - Appointments and Schedules KW - Recurrence KW - Socioeconomic Factors KW - Prescription Fees KW - Ethnic Groups KW - Life Change Events KW - Adult KW - Crime -- statistics & numerical data KW - Heroin Dependence -- rehabilitation KW - Maryland -- epidemiology KW - Female KW - Male KW - Substance Abuse Treatment Centers -- statistics & numerical data KW - Patient Discharge -- statistics & numerical data KW - Methadone -- therapeutic use KW - Patient Discharge -- economics KW - Narcotics -- economics KW - Methadone -- economics KW - Narcotics -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation KW - Opioid-Related Disorders -- economics KW - Substance Abuse Treatment Centers -- manpower KW - Substance Abuse Treatment Centers -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734190823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=Premature+discharge+from+methadone+treatment%3A+patient+perspectives.&rft.au=Reisinger%2C+Heather+Schacht%3BSchwartz%2C+Robert+P%3BMitchell%2C+Shannon+Gwin%3BPeterson%2C+James+A%3BKelly%2C+Sharon+M%3BO%27Grady%2C+Kevin+E%3BMarrari%2C+Erica+A%3BBrown%2C+Barry+S%3BAgar%2C+Michael+H&rft.aulast=Reisinger&rft.aufirst=Heather&rft.date=2009-09-01&rft.volume=41&rft.issue=3&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-19 N1 - Date created - 2009-12-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Subst Use Misuse. 1999 Dec;34(14):2135-53 [10573308] J Psychoactive Drugs. 2009 Jun;41(2):145-52 [19705676] Mt Sinai J Med. 2001 Jan;68(1):21-7 [11135502] Cochrane Database Syst Rev. 2003;(2):CD002209 [12804430] Drug Alcohol Depend. 2004 May 10;74(2):177-85 [15099661] J Urban Health. 2004 Dec;81(4):645-54 [15466845] Med J Aust. 1991 Feb 4;154(3):195-9 [1988793] J Acquir Immune Defic Syndr. 1993 Sep;6(9):1049-56 [8340896] J Subst Abuse Treat. 1995 Jan-Feb;12(1):19-27 [7752293] J Subst Abuse. 1995;7(1):9-26 [7655314] J Subst Abuse Treat. 1996 Jan-Feb;13(1):79-83 [8699547] Am J Public Health. 1998 Jan;88(1):34-9 [9584030] Addiction. 1998 Jan;93(1):51-60 [9624711] Public Health Rep. 1998 Jun;113 Suppl 1:107-15 [9722816] Addiction. 1998 Aug;93(8):1177-90 [9813899] Drug Alcohol Depend. 1998 Nov 1;52(3):257-60 [9839152] JAMA. 1999 Mar 17;281(11):1000-5 [10086434] Arch Gen Psychiatry. 1999 Jun;56(6):507-14 [10359464] Subst Use Misuse. 1999 Jul;34(9):1299-324 [10419225] JAMA. 1965 Aug 23;193:646-50 [14321530] J Behav Health Serv Res. 2005 Jan-Mar;32(1):43-60 [15632797] Addiction. 2005 Aug;100(8):1035 [16042623] J Urban Health. 2005 Sep;82(3):411-9 [15917502] Arch Gen Psychiatry. 2006 Jan;63(1):102-9 [16389204] Med Health R I. 2007 May;90(5):157-8 [17557660] Am J Drug Alcohol Abuse. 2008;34(1):17-28 [18161640] Addiction. 2008 Feb;103(2):251-5 [18199304] Drug Alcohol Depend. 2008 Apr 1;94(1-3):151-7 [18155364] Sci Pract Perspect. 2002 Jul;1(1):22-8 [18567961] Addiction. 2000 May;95(5):697-704 [10885044] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mortality risk in patients receiving drug regimens with theophylline for chronic obstructive pulmonary disease. AN - 734016220; 19698009 AB - To evaluate outcomes associated with six treatment regimens with theophylline versus each regimen without theophylline in patients with chronic obstructive pulmonary disease (COPD). Retrospective cohort study. Veterans Affairs health care system. A total of 183,573 patients aged 45 years or older who had a diagnosis of COPD and were receiving respiratory drug therapy. Patients' treatment regimens were identified by using data from October 1, 2002-March 31, 2003, and patients were followed for events by using data from April 1, 2003-September 30, 2005. Data from October 1, 2001-September 30, 2002, were used to define the patients' baseline characteristics. Primary outcome measures were all-cause mortality, COPD exacerbations, and COPD-related hospitalizations. Two approaches were used: first, treatment assignment was based on drug therapy at baseline, and second, exposure was measured as a time-varying covariate. Treatment groups were stratified based on propensity to receive theophylline. Mortality was compared by using Cox proportional hazards models, and other outcomes were compared with use of negative binomial models. Comparisons were conducted within individual treatment regimens that were the same with the exception of theophylline. Patients treated with ipratropium plus theophylline (largest group) compared with those treated with ipratropium alone had a 1.11-fold increase in the risk of death (95% confidence interval [CI] 1.04-1.18). For each of the other regimens, the risk of mortality associated with theophylline was greater than that in the regimens without theophylline (hazard ratios [HRs] 1.17-1.31). In the time-varying exposure analysis, theophylline (HR 1.23, 95% CI 1.09-1.39) was associated with an increased mortality risk. Patients receiving regimens that included theophylline had slightly increased risks of mortality, COPD exacerbations, and COPD hospitalizations compared with patients receiving the same regimens without theophylline. However, the benefits of theophylline on other factors, including symptoms, quality of life, and activities of daily living, were not measured. Clinicians should consider all of the potential benefits and harms associated with theophylline when making treatment recommendations. JF - Pharmacotherapy AU - Lee, Todd A AU - Schumock, Glen T AU - Bartle, Brian AU - Pickard, A Simon AD - Center for Management of Complex Chronic Care, Hines Veterans Affairs Hospital, Hines, Illinois 60141, USA. todd.lee@va.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1039 EP - 1053 VL - 29 IS - 9 KW - Adrenergic beta-Antagonists KW - 0 KW - Bronchodilator Agents KW - Cholinergic Antagonists KW - Theophylline KW - C137DTR5RG KW - Ipratropium KW - GR88G0I6UL KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Retrospective Studies KW - Adrenergic beta-Antagonists -- adverse effects KW - Aged KW - Cause of Death KW - Drug Therapy, Combination KW - Hospitalization KW - Risk Factors KW - Cohort Studies KW - Administration, Inhalation KW - Adrenergic beta-Antagonists -- therapeutic use KW - Female KW - Male KW - Survival Analysis KW - Proportional Hazards Models KW - Veterans KW - Ipratropium -- adverse effects KW - Theophylline -- adverse effects KW - Bronchodilator Agents -- therapeutic use KW - Cholinergic Antagonists -- therapeutic use KW - Pulmonary Disease, Chronic Obstructive -- drug therapy KW - Ipratropium -- therapeutic use KW - Cholinergic Antagonists -- adverse effects KW - Bronchodilator Agents -- adverse effects KW - Theophylline -- therapeutic use KW - Pulmonary Disease, Chronic Obstructive -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734016220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Mortality+risk+in+patients+receiving+drug+regimens+with+theophylline+for+chronic+obstructive+pulmonary+disease.&rft.au=Lee%2C+Todd+A%3BSchumock%2C+Glen+T%3BBartle%2C+Brian%3BPickard%2C+A+Simon&rft.aulast=Lee&rft.aufirst=Todd&rft.date=2009-09-01&rft.volume=29&rft.issue=9&rft.spage=1039&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=1875-9114&rft_id=info:doi/10.1592%2Fphco.29.9.1039 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-11 N1 - Date created - 2009-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1592/phco.29.9.1039 ER - TY - JOUR T1 - Women, alcohol, and the military: cultural changes and reductions in later alcohol problems among female veterans. AN - 67646433; 19702478 AB - Women working in traditionally male-dominated environments are at higher risk for alcohol use disorders (AUDs). The male-dominated U.S. military has additional risk factors associated with problem drinking, including isolation from family and exposure to life-threatening stressors. In the 1980s, the military conformed to all U.S. states' 21-year minimum legal drinking age (MLDA), and established prevention and intervention policies for abusive drinking. Using a serial cross-sectional design, we explored trends in annual alcohol treatment rates among female veterans versus civilians. From the Department of Health's Treatment Episode Data Set, we extracted AUD admissions from years 1992-2003 for female veterans and civilians in four age categories. Using age-specific population figures, we calculated annual AUD treatment rates and odds ratios for female veterans versus civilians. We used time-series analyses to examine trends in annual AUD treatment for female veterans and civilians across the years examined. In 1992, odds ratios of alcohol treatment episodes for female veterans compared to civilians ranged from 1.9 for 25-29-year-olds to 4.2 for 40-44-year-olds (all p < 0.01). Female veterans' annual alcohol treatment rates dropped substantially from 1992 to 2003, while rates for female civilians ages 25-34 dropped marginally and those for civilians ages 35-44 increased. Time-series analysis showed a statistically significant drop in rates for veterans from 1992 to 2003 and a significant difference between veterans' and civilians' rates, but demonstrated that female civilian annual treatment rates remained static from 1992 to 2003. Prior to the military's efforts to reduce underage and problem drinking, female veterans' alcohol treatment rates exceeded those of same-age civilians. However, with increasing exposure to an environment that discourages abusive drinking, female veterans' annual rates of alcohol treatment fell to below those for same-age civilians. JF - Journal of women's health (2002) AU - Wallace, Amy E AU - Sheehan, Edward P AU - Young-Xu, Yinong AD - Veterans Administration Medical Center, White River Junction, Vermont 05009, USA. aew@dartmouth.edu Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1347 EP - 1353 VL - 18 IS - 9 KW - Index Medicus KW - Cross-Sectional Studies KW - Odds Ratio KW - Risk-Taking KW - Humans KW - Adult KW - Health Behavior KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Prevalence KW - Age Distribution KW - Veterans -- statistics & numerical data KW - Women's Health KW - Military Personnel -- psychology KW - Veterans -- psychology KW - Military Personnel -- statistics & numerical data KW - Alcohol Drinking -- prevention & control KW - Alcohol Drinking -- epidemiology KW - Alcohol-Related Disorders -- psychology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67646433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+women%27s+health+%282002%29&rft.atitle=Women%2C+alcohol%2C+and+the+military%3A+cultural+changes+and+reductions+in+later+alcohol+problems+among+female+veterans.&rft.au=Wallace%2C+Amy+E%3BSheehan%2C+Edward+P%3BYoung-Xu%2C+Yinong&rft.aulast=Wallace&rft.aufirst=Amy&rft.date=2009-09-01&rft.volume=18&rft.issue=9&rft.spage=1347&rft.isbn=&rft.btitle=&rft.title=Journal+of+women%27s+health+%282002%29&rft.issn=1931-843X&rft_id=info:doi/10.1089%2Fjwh.2008.0861 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-10 N1 - Date created - 2009-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/jwh.2008.0861 ER - TY - JOUR T1 - Neuropsychologic assessment of a population-based sample of Gulf War veterans. AN - 67640267; 19741325 AB - The objective of this project was to compare neuropsychologic performance and quality of life in a population-based sample of deployed Gulf War (GW) veterans with and without multisymptom complaints. The study participants were obtained from the 30,000 member population-based National Health Survey of GW-era veterans conducted in 1995. Cases (N=25) were deployed to the year 1990 and 1991 GW and met Center for Disease Control and Prevention criteria for multisymptom GW illness (GWI). Controls (N=16) were deployed to the 1990 and 1991 GW but did not meet Center for Disease Control and Prevention criteria for GWI. There were no significant differences in composite scores on the traditional and computerized neuropsychologic battery (automated neuropsychologic assessment metrics) between GW cases and controls using bivariate techniques. Multiple linear regression analyses controlling for demographic and clinical variables revealed composite automated neuropsychologic assessment metrics scores were associated with age (b=-7.8; P=0.084), and education (b=22.9; P=0.0012), but not GW case or control status (b=-63.9; P=0.22). Compared with controls, GW cases had significantly more impairment on the Personality Assessment Inventory and the short form-36. Compared with GW controls, GW cases meeting criteria for GWI had preserved cognition function but had significant psychiatric symptoms and lower quality of life. JF - Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology AU - Wallin, Mitchell T AU - Wilken, Jeffrey AU - Alfaro, Mercedes H AU - Rogers, Catherine AU - Mahan, Clare AU - Chapman, Julie C AU - Fratto, Timothy AU - Sullivan, Cynthia AU - Kang, Han AU - Kane, Robert AD - War Related Illness and Injury Study Center, Veterans Affairs Health Administration, Georgetown University School of Medicine, Washington, DC 20422, USA. mitchell.wallin@va.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 155 EP - 166 VL - 22 IS - 3 KW - Index Medicus KW - Regression Analysis KW - Educational Status KW - Age Factors KW - Humans KW - Health Surveys KW - Adult KW - Quality of Life KW - Middle Aged KW - Personality Assessment KW - Patient Selection KW - Neuropsychological Tests KW - Male KW - Female KW - Cognition KW - Gulf War KW - Veterans -- psychology KW - Persian Gulf Syndrome -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67640267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cognitive+and+behavioral+neurology+%3A+official+journal+of+the+Society+for+Behavioral+and+Cognitive+Neurology&rft.atitle=Neuropsychologic+assessment+of+a+population-based+sample+of+Gulf+War+veterans.&rft.au=Wallin%2C+Mitchell+T%3BWilken%2C+Jeffrey%3BAlfaro%2C+Mercedes+H%3BRogers%2C+Catherine%3BMahan%2C+Clare%3BChapman%2C+Julie+C%3BFratto%2C+Timothy%3BSullivan%2C+Cynthia%3BKang%2C+Han%3BKane%2C+Robert&rft.aulast=Wallin&rft.aufirst=Mitchell&rft.date=2009-09-01&rft.volume=22&rft.issue=3&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Cognitive+and+behavioral+neurology+%3A+official+journal+of+the+Society+for+Behavioral+and+Cognitive+Neurology&rft.issn=1543-3641&rft_id=info:doi/10.1097%2FWNN.0b013e3181b278e8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-05 N1 - Date created - 2009-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/WNN.0b013e3181b278e8 ER - TY - JOUR T1 - Hematology: Azacitidine improves survival in myelodysplastic syndromes. AN - 67607270; 19707240 JF - Nature reviews. Clinical oncology AU - Rose, Michal G AD - Comprehensive Cancer Center, Veterans Administration Connecticut Healthcare System, CT 06516, USA. michal.rose@va.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 502 EP - 503 VL - 6 IS - 9 KW - Antimetabolites, Antineoplastic KW - 0 KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Multicenter Studies as Topic KW - Clinical Trials, Phase III as Topic KW - Humans KW - Practice Guidelines as Topic KW - Quality of Life KW - Time Factors KW - Survival Analysis KW - Azacitidine -- therapeutic use KW - Azacitidine -- adverse effects KW - Myelodysplastic Syndromes -- drug therapy KW - Myelodysplastic Syndromes -- mortality KW - Hematology KW - Antimetabolites, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67607270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Clinical+oncology&rft.atitle=Hematology%3A+Azacitidine+improves+survival+in+myelodysplastic+syndromes.&rft.au=Rose%2C+Michal+G&rft.aulast=Rose&rft.aufirst=Michal&rft.date=2009-09-01&rft.volume=6&rft.issue=9&rft.spage=502&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Clinical+oncology&rft.issn=1759-4782&rft_id=info:doi/10.1038%2Fnrclinonc.2009.125 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-04 N1 - Date created - 2009-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/nrclinonc.2009.125 ER - TY - JOUR T1 - Acute hepatic injury associated with varenicline in a patient with underlying liver disease. AN - 67606098; 19638471 AB - To report a case of acute hepatic injury associated with varenicline. A 53-year-old white male with underlying alcoholic liver disease and history of hepatitis C virus infection experienced elevated aminotransferase and alkaline phosphatase levels consistent with acute hepatic injury after initiation of varenicline for smoking cessation. The hepatic injury manifested 4 weeks after initiation of varenicline therapy at 0.5 mg once daily for 3 days, 0.5 mg twice daily for 4 days, and then 1 mg twice daily. Following discontinuation of varenicline, the patient's aminotransferase levels continued to rise for 2 days before steadily decreasing and returning to baseline levels in approximately 4 months. Alkaline phosphatase continued to rise for 8 days after discontinuation of varenicline before returning to baseline within 1 month. Rechallenge was not attempted. Varenicline is a novel, first-line agent for smoking cessation. The presentation of this patient is most consistent with an acute hepatic injury related to drug toxicity. The pattern of the patient's elevated hepatic enzyme levels is not consistent with his underlying alcoholic liver disease or hepatitis C. Using the Naranjo probability scale, as well as the Counsel for International Organizations of Medical Science/Roussel Uclaf Causality Assessment Method algorithm for drug-induced liver toxicity, we determined that varenicline was the probable cause of the acute hepatic injury. Varenicline was a possible cause of the acute hepatic injury using the algorithm for drug-induced liver toxicity developed by Maria and Victorino. To our knowledge, this is the first report of acute hepatic injury associated with varenicline. While the benefits of smoking cessation are likely greater than the risk of hepatic injury, clinicians should be cognizant of this reaction associated with varenicline. JF - The Annals of pharmacotherapy AU - Franck, Andrew J AU - Sliter, Lisa R AD - Department of Pharmacy, North Florida/South Georgia Veterans Health System, Gainesville, FL 32608, USA. Andrew.Franck@va.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1539 EP - 1543 VL - 43 IS - 9 KW - Benzazepines KW - 0 KW - Nicotinic Agonists KW - Quinoxalines KW - Varenicline KW - W6HS99O8ZO KW - Index Medicus KW - Acute Disease KW - Hepatitis C -- complications KW - Humans KW - Smoking Cessation -- methods KW - Middle Aged KW - Liver Function Tests KW - Liver Diseases, Alcoholic -- complications KW - Male KW - Liver Diseases -- physiopathology KW - Quinoxalines -- therapeutic use KW - Quinoxalines -- adverse effects KW - Nicotinic Agonists -- therapeutic use KW - Liver Diseases -- etiology KW - Benzazepines -- adverse effects KW - Nicotinic Agonists -- adverse effects KW - Benzazepines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67606098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Acute+hepatic+injury+associated+with+varenicline+in+a+patient+with+underlying+liver+disease.&rft.au=Franck%2C+Andrew+J%3BSliter%2C+Lisa+R&rft.aulast=Franck&rft.aufirst=Andrew&rft.date=2009-09-01&rft.volume=43&rft.issue=9&rft.spage=1539&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=1542-6270&rft_id=info:doi/10.1345%2Faph.1M131 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-02 N1 - Date created - 2009-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1345/aph.1M131 ER - TY - JOUR T1 - Neurological mortality among U.S. veterans of the Persian Gulf War: 13-year follow-up. AN - 67593008; 19585544 AB - This study focuses on long-term mortality, specifically brain cancer, amyotrophic lateral sclerosis (ALS), Parkinson's disease, and multiple sclerosis (MS) of 621,902 veterans who served in the 1990-1991 Persian Gulf War (GW), and 746,248 non-GW veterans. Follow-up began with the date the veteran left the GW theater or May 1, 1991 and ended with the date of death or December 31, 2004. Cox proportional hazard models were used for analyses. Adjusted mortality rate ratios (aRR) of GW veterans compared to non-GW veterans were not statistically significant for brain cancer (aRR = 0.90, 95% confidence interval (CI): 0.73, 1.11), MS (aRR = 0.61, 95% CI: 0.23, 1.63), Parkinson's disease (aRR = 0.71, 95% CI: 0.17, 2.99), or ALS (aRR = 0.96, 95% CI: 0.56, 1.62). GW veterans potentially exposed to nerve agents for 2 or more days and GW veterans exposed to oil well fire smoke were at increased risk for brain cancer mortality (aRR = 2.71, 95% CI: 1.25, 5.87; aRR = 1.81, 95% CI: 1.00, 3.27; respectively). The risk of death due to ALS, MS, Parkinson's disease, and brain cancer was not associated with 1991 GW service in general. However, GW veterans potentially exposed to nerve agents at Khamisiyah, Iraq, and to oil well fire smoke had an increased risk of mortality due to brain cancer. (c) 2009 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Barth, Shannon K AU - Kang, Han K AU - Bullman, Tim A AU - Wallin, Mitchell T AD - Department of Veterans Affairs, Environmental Epidemiology Service, Washington, District of Columbia 20420, USA. shannon.barth@va.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 663 EP - 670 VL - 52 IS - 9 KW - Chemical Warfare Agents KW - 0 KW - Smoke KW - Index Medicus KW - Smoke -- adverse effects KW - Parkinson Disease -- mortality KW - Occupational Exposure -- statistics & numerical data KW - Brain Neoplasms -- mortality KW - Humans KW - Chemical Warfare Agents -- adverse effects KW - Multiple Sclerosis -- mortality KW - Age Distribution KW - Adult KW - Amyotrophic Lateral Sclerosis -- mortality KW - Occupational Exposure -- adverse effects KW - Middle Aged KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Male KW - Veterans KW - Gulf War KW - Nervous System Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67593008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Neurological+mortality+among+U.S.+veterans+of+the+Persian+Gulf+War%3A+13-year+follow-up.&rft.au=Barth%2C+Shannon+K%3BKang%2C+Han+K%3BBullman%2C+Tim+A%3BWallin%2C+Mitchell+T&rft.aulast=Barth&rft.aufirst=Shannon&rft.date=2009-09-01&rft.volume=52&rft.issue=9&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=1097-0274&rft_id=info:doi/10.1002%2Fajim.20718 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-03 N1 - Date created - 2009-08-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Ind Med. 2010 May;53(5):548-9 [20191602] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajim.20718 ER - TY - JOUR T1 - Civility, Respect, Engagement in the Workforce (CREW) AN - 57290140; 200927650 AB - This article presents a description and preliminary evaluation of a nationwide initiative by the Veterans Health Administration (VHA) called Civility, Respect, and Engagement in the Workforce (CREW). The goal of CREW is to increase workplace civility as assessed by employee ratings of interpersonal climate in workgroups. Once endorsed by the VHA leadership and adopted by the leaders of particular VHA hospitals, CREW was conducted by local facility coordinators who were trained and supported by the VHA National Center for Organization Development. This article explains the conceptual and operational background of CREW and the approach used to implement the initiative, presents results from two CREW administrations with a total of 23 sites, and reports significant preintervention to postintervention changes in civility at intervention sites as compared to no significant changes at comparison sites within each administration. It discusses these findings in the conceptual (theoretical) and operational (intervention evaluation) context of interventions targeting civility. [Reprinted by permission of Sage Publications, Inc., copyright NTL Institute.] JF - The Journal of Applied Behavioral Science AU - Osatuke, Katerine AU - Moore, Scott C AU - Ward, Christopher AU - Dyrenforth, Sue R AU - Belton, Linda AD - Veterans Health Administration National Center Organization Development Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 384 EP - 410 PB - Sage Publications, Thousand Oaks CA VL - 45 IS - 3 SN - 0021-8863, 0021-8863 KW - civility organization development intervention evaluation survey feedback KW - Occupational health and safety KW - Crews KW - Labour force KW - Civility KW - Leadership KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57290140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Applied+Behavioral+Science&rft.atitle=Civility%2C+Respect%2C+Engagement+in+the+Workforce+%28CREW%29&rft.au=Osatuke%2C+Katerine%3BMoore%2C+Scott+C%3BWard%2C+Christopher%3BDyrenforth%2C+Sue+R%3BBelton%2C+Linda&rft.aulast=Osatuke&rft.aufirst=Katerine&rft.date=2009-09-01&rft.volume=45&rft.issue=3&rft.spage=384&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Applied+Behavioral+Science&rft.issn=00218863&rft_id=info:doi/10.1177%2F0021886309335067 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JABHAP N1 - SubjectsTermNotLitGenreText - Crews; Civility; Labour force; Leadership; Hospitals; Occupational health and safety DO - http://dx.doi.org/10.1177/0021886309335067 ER - TY - JOUR T1 - Thumb Infection Caused by Streptococcus pseudoporcinus AN - 21494589; 12512020 AB - Streptococcus pseudoporcinus, a recently described organism found in the genitourinary tract of women, was isolated from a thumb wound in a male patient subsequent to trauma. This case describes a rarely reported non-genitourinary tract clinical isolate of S. pseudoporcinus. JF - Journal of Clinical Microbiology AU - Mahlen, Steven D AU - Clarridge III, Jill E AD - U.S. Army with duty at the Department of Laboratory Medicine, University of Washington, Jill.clarridge@va.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 3041 EP - 3042 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 47 IS - 9 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Clinical isolates KW - Genitourinary tract KW - Infection KW - Wounds KW - Trauma KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21494589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Thumb+Infection+Caused+by+Streptococcus+pseudoporcinus&rft.au=Mahlen%2C+Steven+D%3BClarridge+III%2C+Jill+E&rft.aulast=Mahlen&rft.aufirst=Steven&rft.date=2009-09-01&rft.volume=47&rft.issue=9&rft.spage=3041&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00802-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Genitourinary tract; Infection; Trauma; Wounds; Streptococcus DO - http://dx.doi.org/10.1128/JCM.00802-09 ER - TY - JOUR T1 - Physical activity and subclinical MRI cerebral infarcts: The ARIC Study AN - 20706564; 10870313 AB - We hypothesized that physical activity (PA), which is often associated with reduced risk of ischemic stroke, may also be associated with reduced risk of subclinical cerebral infarcts. Objectives - We studied the cross-sectional association between PA and subclinical cerebral infarcts among African-Americans in the Atherosclerosis Risk in Communities (ARIC) Study. Methods - PA self-reported at baseline and images from cerebral MRI examination obtained 6 years later were evaluated for presence and location of subclinical infarcts >= 3 mm in size. After exclusions, 944 participants were eligible for study. Results - The results suggested an inverse relationship between odds of having a subclinical cerebral infarct and level of PA on several measures, although the multivariable adjusted odds ratios (OR) were statistically significant only for the sport score. A 1-unit increase in the sport score, indicating more leisure PA, was associated with an adjusted OR for having a subclinical cerebral infarct of 0.62 (0.44-0.87), with a statistically significant monotonic trend across quartiles of the score (P = 0.01). There was no association of work scores with subclinical infarcts. Conclusions - In African-Americans, sport PA was inversely related to subclinical MRI-detected cerebral infarcts assessed six years later. JF - Journal of the Neurological Sciences AU - Dubbert, Patricia M AU - Penman, Alan D AU - Evenson, Kelly R AU - Reeves, Roy R AU - Mosley, Thomas H AD - G.V. Sonny Montgomery Veterans Affairs Medical Center (11M), 1500 E. Woodrow Wilson, Jackson, MS 39216, United States, Patricia.Dubbert@va.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 135 EP - 139 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 284 IS - 1-2 SN - 0022-510X, 0022-510X KW - CSA Neurosciences Abstracts; Physical Education Index KW - Statistics KW - Physical activity KW - Magnetic resonance imaging KW - Stroke KW - Statistical analysis KW - Work KW - Blood diseases KW - Arteriosclerosis KW - Ischemia KW - Exercise KW - Sports KW - scoring KW - Evaluation KW - Leisure KW - Cerebral infarction KW - PE 040:Sports & Athletics KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20706564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Neurological+Sciences&rft.atitle=Physical+activity+and+subclinical+MRI+cerebral+infarcts%3A+The+ARIC+Study&rft.au=Dubbert%2C+Patricia+M%3BPenman%2C+Alan+D%3BEvenson%2C+Kelly+R%3BReeves%2C+Roy+R%3BMosley%2C+Thomas+H&rft.aulast=Dubbert&rft.aufirst=Patricia&rft.date=2009-09-01&rft.volume=284&rft.issue=1-2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Neurological+Sciences&rft.issn=0022510X&rft_id=info:doi/10.1016%2Fj.jns.2009.04.011 LA - English DB - Physical Education Index N1 - Date revised - 2009-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - scoring; Sports; Statistics; Exercise; Work; Stroke; Evaluation; Leisure; Blood diseases; Cerebral infarction; Magnetic resonance imaging; Statistical analysis; Physical activity; Ischemia; Arteriosclerosis DO - http://dx.doi.org/10.1016/j.jns.2009.04.011 ER - TY - JOUR T1 - Neutrophil bleaching of GFP-expressing staphylococci: probing the intraphagosomal fate of individual bacteria. AN - 67561124; 19620311 AB - Successful host defense against bacteria such as Staphylococcus aureus (SA) depends on a prompt response by circulating polymorphonuclear leukocytes (PMN). Stimulated PMN create in their phagosomes an environment inhospitable to most ingested bacteria. Granules that fuse with the phagosome deliver an array of catalytic and noncatalytic antimicrobial peptides, while activation of the NADPH oxidase at the phagosomal membrane generates reactive oxygen species within the phagosome, including hypochlorous acid (HOCl), formed by the oxidation of chloride by the granule protein myeloperoxidase in the presence of H(2)O(2). In this study, we used SA-expressing cytosolic GFP to provide a novel probe of the fate of SA in human PMN. PMN bleaching of GFP in SA required phagocytosis, active myeloperoxidase, H(2)O(2) from the NADPH oxidase, and chloride. Not all ingested SA were bleached, and the number of cocci within PMN-retaining fluorescent GFP closely correlated with the number of viable bacteria remaining intracellularly. The percent of intracellular fluorescent and viable SA increased at higher multiplicity of infection and when SA presented to PMN had been harvested from the stationary phase of growth. These studies demonstrate that the loss of GFP fluorescence in ingested SA provides a sensitive experimental probe for monitoring biochemical events within individual phagosomes and for identifying subpopulations of SA that resist intracellular PMN cytotoxicity. Defining the molecular basis of SA survival within PMN should provide important insights into bacterial and host properties that limit PMN antistaphylococcal action and thus contribute to the pathogenesis of staphylococcal infection. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Schwartz, Jamie AU - Leidal, Kevin G AU - Femling, Jon K AU - Weiss, Jerrold P AU - Nauseef, William M AD - Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, and Veterans Administration Medical Center, Iowa City, IA 52240, USA. Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 2632 EP - 2641 VL - 183 IS - 4 KW - Chlorides KW - 0 KW - Cytotoxins KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Hypochlorous Acid KW - 712K4CDC10 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Peroxidase KW - EC 1.11.1.7 KW - Abridged Index Medicus KW - Index Medicus KW - Peroxidase -- pharmacology KW - Peroxidase -- genetics KW - Humans KW - Cytotoxins -- physiology KW - Hypochlorous Acid -- pharmacology KW - Hydrogen Peroxide -- pharmacology KW - Peroxidase -- deficiency KW - Chlorides -- pharmacology KW - Phagosomes -- drug effects KW - Neutrophils -- drug effects KW - Phagosomes -- immunology KW - Green Fluorescent Proteins -- physiology KW - Staphylococcus aureus -- immunology KW - Green Fluorescent Proteins -- biosynthesis KW - Neutrophils -- immunology KW - Staphylococcus aureus -- growth & development KW - Green Fluorescent Proteins -- antagonists & inhibitors KW - Phagocytosis -- drug effects KW - Staphylococcus aureus -- drug effects KW - Phagocytosis -- immunology KW - Neutrophils -- microbiology KW - Phagosomes -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67561124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Neutrophil+bleaching+of+GFP-expressing+staphylococci%3A+probing+the+intraphagosomal+fate+of+individual+bacteria.&rft.au=Schwartz%2C+Jamie%3BLeidal%2C+Kevin+G%3BFemling%2C+Jon+K%3BWeiss%2C+Jerrold+P%3BNauseef%2C+William+M&rft.aulast=Schwartz&rft.aufirst=Jamie&rft.date=2009-08-15&rft.volume=183&rft.issue=4&rft.spage=2632&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.0804110 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-09 N1 - Date created - 2009-08-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Pharmacol. 2000 Aug 4;401(2):115-20 [10924915] J Infect Dis. 2008 Oct 15;198(8):1166-70 [18729780] J Biol Chem. 2002 Mar 22;277(12):9757-62 [11733505] Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3481-6 [11904413] J Immunol. 2003 Nov 15;171(10):5389-95 [14607942] Nature. 1969 Jul 5;223(5201):78-9 [4978299] J Reticuloendothel Soc. 1972 Aug;12(2):170-96 [5075520] J Clin Invest. 1975 May;55(5):945-55 [1123431] Scand J Haematol. 1976 Feb;16(2):144-53 [176720] J Clin Invest. 1976 Jul;58(1):50-60 [180060] J Biol Chem. 1977 Feb 10;252(3):1102-6 [320200] J Lab Clin Med. 1977 Mar;89(3):675-86 [839126] J Clin Invest. 1977 Dec;60(6):1266-79 [199619] J Clin Invest. 1978 May;61(5):1176-85 [207730] Blood. 1979 Mar;53(3):403-11 [216438] Infect Immun. 1979 Feb;23(2):522-31 [217834] Infect Immun. 1979 Jul;25(1):110-6 [39030] Infect Immun. 1981 Jan;31(1):11-6 [6260658] Proc Natl Acad Sci U S A. 1981 Jan;78(1):210-4 [6264434] Blood. 1983 Mar;61(3):483-92 [6297637] J Cell Biol. 1983 Jul;97(1):52-61 [6408102] J Clin Invest. 1986 Jul;78(1):177-84 [3013936] Infect Immun. 1987 Oct;55(10):2518-25 [2820883] J Biol Chem. 1987 Nov 5;262(31):15004-10 [2822709] Biochem J. 1988 May 1;251(3):887-91 [2843166] J Biol Chem. 1994 Jan 14;269(2):1212-6 [7904599] Biochem Biophys Res Commun. 1995 Jul 26;212(3):868-74 [7626123] J Biol Chem. 1997 Dec 26;272(52):32767-72 [9407050] Blood. 1998 Nov 1;92(9):3007-17 [9787133] Infect Immun. 1998 Dec;66(12):5988-93 [9826382] J Exp Med. 1952 Feb;95(2):209-30 [14907971] J Exp Med. 1960 Dec 1;112:1121-30 [13769271] Bacteriol Rev. 1960 Mar;24(1):50-66 [14438353] J Leukoc Biol. 2005 May;77(5):598-625 [15689384] Biochemistry. 2005 May 10;44(18):6910-9 [15865436] J Immunol. 2005 Sep 15;175(6):3907-19 [16148137] J Immunol. 2005 Oct 1;175(7):4653-61 [16177112] Free Radic Biol Med. 2005 Dec 1;39(11):1468-77 [16274882] Nat Rev Microbiol. 2005 Dec;3(12):948-58 [16322743] J Infect Dis. 2006 Dec 15;194(12):1761-70 [17109350] Curr Med Chem. 2006;13(27):3271-90 [17168851] Cell Microbiol. 2007 May;9(5):1172-90 [17217429] J Allergy Clin Immunol. 2007 Jul;120(1):13-22 [17606031] Immunol Rev. 2007 Oct;219:88-102 [17850484] Nat Med. 2007 Dec;13(12):1510-4 [17994102] Nat Med. 2007 Dec;13(12):1418-20 [18064034] J Immunol. 2008 Jan 1;180(1):500-9 [18097052] Methods Mol Biol. 2008;431:109-22 [18287751] Science. 2008 May 2;320(5876):674-7 [18403674] Methods Mol Biol. 2007;412:15-20 [18453102] PLoS One. 2008;3(9):e3198 [18787708] Chem Res Toxicol. 2001 Oct;14(10):1453-64 [11599938] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4049/jimmunol.0804110 ER - TY - JOUR T1 - Severe Dysglycemia with the Fluoroquinolones: A Class Effect? AN - 746157214; 13054226 AB - Background. Although gatifloxacin is no longer available, other fluoroquinolones may significantly interfere with glucose homeostasls. The objective of the present study was to compare the risk of severe hypo- and hyperglycemia in a cohort of patients treated with gatifloxacin, levofloxacin, ciprofloxacin, or azithromycin. Methods. This was a retrospective inception cohort study of outpatients with a new prescription for gatifloxacin, levofloxacin, ciprofloxacin, or azithromycin from 1 October 2000 through 30 September 2005 in the Veterans Affalrs health care system. For patients who received one of these antibiotics, we identified outcomes of hospitalization with a primary diagnosis of hypo- or hyperglycemia. Multivariable logistic regression was used to determine the odds of hypo- and hyperglycemia with the individual fluoroquinolones versus azithromycin. Results. The crude incidence rates for severe hypo- and hyperglycemia among those who received gatifloxacin, levofloxacln, ciprofloxacin, and azithromycin were 0.35 and 0.45, 0.19 and 0.18, 0.10 and 0.12, and 0.07 and 0.10 cases per 1000 patients, respectively. Among patients with diabetes, the odds ratios for hypoglycemla compared with azithromycin were 4.3 (95% confidence interval [CI], 2.7-6.6) for gatifloxacin, 2.1 (95% CI, 1.4-3.3) for levofloxacin, and 1.1 (95% CI, 0.6-2.0) for ciprofloxacin. The odds ratios for hyperglycemia were 4.5 (95% CI, 3.0-6.9) for gatifloxacin, 1.8 (95% CI, 1.2-2.7) for levofloxacin, and 1.0 (95% CI, 0.6-1.8) for ciprofloxacin. Conclusions. The odds of severe hypo- and hyperglycemia were significantly greater with gatifloxacin and levofloxacin, but not ciprofloxacin, than with azithromycin. Thus, the risk of a clinically relevant dysglycemic event appears to vary among the fluoroquinolones. JF - Clinical Infectious Diseases AU - Aspinall, S L AU - Good, C B AU - Jiang, R AU - McCarren, M AU - Dong, D AU - Cunningham, F E AD - Veterans Health Administration, Pharmacy Benefits Management Services (119D), Hines, IL 60141, USA, fran.cunningham@va.gov Y1 - 2009/08/01/ PY - 2009 DA - 2009 Aug 01 SP - 402 EP - 408 VL - 49 IS - 3 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - Diabetes mellitus KW - Ciprofloxacin KW - Hyperglycemia KW - Fluoroquinolones KW - Azithromycin KW - Levofloxacin KW - Glucose KW - Antibiotics KW - Gatifloxacin KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746157214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Severe+Dysglycemia+with+the+Fluoroquinolones%3A+A+Class+Effect%3F&rft.au=Aspinall%2C+S+L%3BGood%2C+C+B%3BJiang%2C+R%3BMcCarren%2C+M%3BDong%2C+D%3BCunningham%2C+F+E&rft.aulast=Aspinall&rft.aufirst=S&rft.date=2009-08-01&rft.volume=49&rft.issue=3&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F600294 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Ciprofloxacin; Hyperglycemia; Fluoroquinolones; Levofloxacin; Azithromycin; Glucose; Antibiotics; Gatifloxacin DO - http://dx.doi.org/10.1086/600294 ER - TY - JOUR T1 - Human evoked cortical activity to signal-to-noise ratio and absolute signal level. AN - 742778486; pmid-19364526 AB - The purpose of this study was to determine the effect of signal level and signal-to-noise ratio (SNR) on the latency and amplitude of evoked cortical activity to further our understanding of how the human central auditory system encodes signals in noise. Cortical auditory evoked potentials (CAEPs) were recorded from 15 young normal-hearing adults in response to a 1000 Hz tone presented at two tone levels in quiet and while continuous background noise levels were varied in five equivalent SNR steps. These 12 conditions were used to determine the effects of signal level and SNR level on CAEP components P1, N1, P2, and N2. Based on prior signal-in-noise experiments conducted in animals, we hypothesized that SNR, would be a key contributor to human CAEP characteristics. As hypothesized, amplitude increased and latency decreased with increasing SNR; in addition, there was no main effect of tone level across the two signal levels tested (60 and 75 dB SPL). Morphology of the P1-N1-P2 complex was driven primarily by SNR, highlighting the importance of noise when recording CAEPs. Results are discussed in terms of the current interest in recording CAEPs in hearing aid users. JF - Hearing research AU - Billings, Curtis J AU - Tremblay, Kelly L AU - Stecker, G Christopher AU - Tolin, Wendy M AD - Department of Speech and Hearing Sciences, University of Washington, 1417 NE 42[nd] Street, Seattle, WA 98105, USA. curtis.billings2@va.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 15 EP - 24 VL - 254 IS - 1-2 SN - 0378-5955, 0378-5955 KW - Index Medicus KW - National Library of Medicine KW - Acoustics KW - Auditory Threshold KW - Humans KW - Evoked Potentials -- physiology KW - Hearing Aids KW - Acoustic Stimulation -- methods KW - Auditory Perception KW - Speech Perception -- physiology KW - Electrophysiology -- methods KW - Adult KW - Electrodes KW - Female KW - Male KW - Auditory Cortex -- metabolism KW - Evoked Potentials, Auditory -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742778486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+research&rft.atitle=Human+evoked+cortical+activity+to+signal-to-noise+ratio+and+absolute+signal+level.&rft.au=Billings%2C+Curtis+J%3BTremblay%2C+Kelly+L%3BStecker%2C+G+Christopher%3BTolin%2C+Wendy+M&rft.aulast=Billings&rft.aufirst=Curtis&rft.date=2009-08-01&rft.volume=254&rft.issue=1-2&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Hearing+research&rft.issn=03785955&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - Distribution and manifestations of inflammatory bowel disease in Asians, Hispanics, and African Americans: a systematic review. AN - 742776169; pmid-19471256 AB - OBJECTIVES: Although inflammatory bowel disease (IBD) has been reported worldwide, most studies have focused on Caucasian populations. Our aim was to summarize the existing epidemiological literature, identify temporal trends, and highlight areas for future research. METHODS: We carried out a systematic review following standard guidelines to evaluate the incidence, prevalence, temporal trends, disease characteristics, and extra-intestinal manifestations (EIMs) of IBD in African American, Hispanic, and Asian adult patients. Two investigators independently identified eligible studies through 2008 using structured keyword searches in PubMed, applied several inclusion and exclusion criteria, and abstracted the data. RESULTS: Twenty-eight publications were included, encompassing 1,272 Hispanic, 547 African American, and 35,844 Asian patients with IBD. Greater proportions of Hispanic (36.7-84.3%) and Asian (30.6-74.7%) patients were diagnosed with ulcerative colitis (UC) than with Crohn's disease (CD) compared with African Americans (27.6-40.6%). The prevalence rates of IBD in Hispanics in Puerto Rico varied between 5 (rural) and 62 (urban) per 100,000. Crude prevalence rates in Asia varied between 6 (Singapore) and 136 (South Asians in UK) per 100,000 for UC, and between 3 (Singapore) and 33 (South Asians in UK) per 100,000 for CD. Three studies reported a rising annual incidence rate among Hispanics (from 2.6 to 7.5 per 100,000) and Asians (from 0.22 to 3.62 per 100,000). Fistulizing CD was reported in nearly one-third of Hispanic patients, up to one-quarter of African-American patients, and up to one-half of Asian patients. Ileocolonic disease was the most common site of CD among the three racial/ethnic groups, with skin and joint manifestations noted as the most common EIMs. CONCLUSIONS: Prevalence and incidence rates in Hispanics and Asians have recently increased. There are many similarities and differences in disease location and behavior among racial/ethnic groups. There is a paucity of literature on all aspects of the disease in Hispanics, in the incidence and prevalence of IBD in African Americans, and in Asians with IBD outside Asia. JF - The American journal of gastroenterology AU - Hou, Jason K AU - El-Serag, Hashem AU - Thirumurthi, Selvi AD - Sections of Gastroenterology and Health Services Research, Michael E. DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA. Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 2100 EP - 2109 VL - 104 IS - 8 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Hispanic Americans KW - Inflammatory Bowel Diseases -- diagnosis KW - African Americans KW - Asian Americans KW - Inflammatory Bowel Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742776169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Distribution+and+manifestations+of+inflammatory+bowel+disease+in+Asians%2C+Hispanics%2C+and+African+Americans%3A+a+systematic+review.&rft.au=Hou%2C+Jason+K%3BEl-Serag%2C+Hashem%3BThirumurthi%2C+Selvi&rft.aulast=Hou&rft.aufirst=Jason&rft.date=2009-08-01&rft.volume=104&rft.issue=8&rft.spage=2100&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - HEDIS initiation and engagement quality measures of substance use disorder care: impact of setting and health care specialty. AN - 733965214; 19663621 AB - Many health care systems track the HEDIS measures of initiation and engagement in substance use disorder (SUD) care. However, the impact of setting of care (inpatient vs. outpatient) and health care specialty (SUD, psychiatric, other) on the likelihood of patients meeting the initiation and engagement criteria are unknown. If the vast majority of initiation and engagement occurs within SUD specialty clinics, then these quality measures could be used to discriminate among and incentivize SUD clinic managers. However, if these criteria are satisfied in different settings and specialties, then they should be considered characteristics of the entire facility, rather than just specialty SUD units. Using a Markov model, the probabilities of advancing to treatment initiation and engagement given initial setting and specialty of care were estimated for 320,238 SUD-diagnosed Veterans Health Affairs (VA) patients. Patients in SUD specialty units progressed more often (diagnosis to initiation, initiation to engagement) than patients in other specialties. Progression through the criteria differed for inpatients vs. outpatients. Approximately 25% of initiation and over 40% of engagement occurred outside of SUD specialty care. VA patients who have contact with SUD specialty treatment have higher rates of advancing to initiation, and from initiation to engagement, compared to SUD-diagnosed patients in psychiatric or other medical locations. Even so, a substantial portion of initiation and engagement occurs outside of SUD specialty units. Therefore, these quality measures should be considered measures of facility performance rather than measures of the quality of SUD specialty care. The usual combining of inpatient and outpatient performance on these measures into overall facility scores clouds measurement and interpretation. JF - Population health management AU - Harris, Alex H S AU - Bowe, Thomas AU - Finney, John W AU - Humphreys, Keith AD - VA Center for Health Care Evaluation, 795 Willow Road, Menlo Park, CA 94025, USA. Alexander.Harris2@va.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 191 EP - 196 VL - 12 IS - 4 KW - Index Medicus KW - Quality Indicators, Health Care KW - United States Department of Veterans Affairs KW - Humans KW - Markov Chains KW - Ambulatory Care Facilities KW - United States -- epidemiology KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- epidemiology KW - Quality Assurance, Health Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733965214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Population+health+management&rft.atitle=HEDIS+initiation+and+engagement+quality+measures+of+substance+use+disorder+care%3A+impact+of+setting+and+health+care+specialty.&rft.au=Harris%2C+Alex+H+S%3BBowe%2C+Thomas%3BFinney%2C+John+W%3BHumphreys%2C+Keith&rft.aulast=Harris&rft.aufirst=Alex+H&rft.date=2009-08-01&rft.volume=12&rft.issue=4&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Population+health+management&rft.issn=1942-7905&rft_id=info:doi/10.1089%2Fpop.2008.0028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-23 N1 - Date created - 2009-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/pop.2008.0028 ER - TY - JOUR T1 - Isoproterenol-induced myocardial injury and diastolic dysfunction in mice: structural and functional correlates. AN - 67620905; 19712573 AB - The objective of this study was to determine whether a simple, noninvasive method involving administration of isoproterenol could be used to produce myocardial injury and cardiac dysfunction in the mouse heart with a low incidence of mortality. Adult Swiss-Webster mice were injected with isoproterenol (100 mg/kg SC) once daily for 5 d. Myocardial histology and left ventricular (LV) function were assessed 10 to 14 d after the last isoproterenol injection in 14 surviving isoproterenol-treated mice and 15 saline-treated control mice. Left ventricular systolic and diastolic pressures were evaluated in vitro by means of isovolumically contracting, perfused Langendorff preparations. Isoproterenol induced marked endocardial injury, associated with hypertrophy of surviving myocytes, and an increase in myocardial fibrosis (collagen types I and III according to picrosirius red microscopy). The hearts from isoproterenol-treated mice demonstrated decreased LV compliance, as evidenced by an upward shift in the diastolic pressure-volume relationship, with normal LV systolic function. Isoproterenol administration provides a simple, noninvasive means to induce endocardial injury and diastolic dysfunction without significant impairment of systolic function. This model has a low incidence of mortality and may be useful to assess the effects of gene or stem cell therapy on cardiac dysfunction without the potential confounding effects of invasive procedures. JF - Comparative medicine AU - Brooks, Wesley W AU - Conrad, Chester H AD - VA Boston Healthcare System and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA. wesley.brooks@va.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 339 EP - 343 VL - 59 IS - 4 SN - 1532-0820, 1532-0820 KW - Adrenergic beta-Agonists KW - 0 KW - Isoproterenol KW - L628TT009W KW - Index Medicus KW - Animals KW - Mice KW - Male KW - Adrenergic beta-Agonists -- toxicity KW - Heart Injuries -- chemically induced KW - Isoproterenol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67620905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comparative+medicine&rft.atitle=Isoproterenol-induced+myocardial+injury+and+diastolic+dysfunction+in+mice%3A+structural+and+functional+correlates.&rft.au=Brooks%2C+Wesley+W%3BConrad%2C+Chester+H&rft.aulast=Brooks&rft.aufirst=Wesley&rft.date=2009-08-01&rft.volume=59&rft.issue=4&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Comparative+medicine&rft.issn=15320820&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-09 N1 - Date created - 2009-08-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Cell Cardiol. 2000 Feb;32(2):187-95 [10722796] Clin Exp Pharmacol Physiol. 2008 May;35(5-6):679-86 [18387083] Recent Adv Stud Cardiac Struct Metab. 1973;3:507-25 [4806665] Recent Adv Stud Cardiac Struct Metab. 1972;1:770-8 [4681502] J Mol Cell Cardiol. 1985 Apr;17(4):291-306 [3894676] Circ Res. 1989 Sep;65(3):657-70 [2527639] Circ Res. 1993 Dec;73(6):1202-7 [8222091] Circ Res. 1994 Jul;75(1):105-13 [8013068] Am J Physiol. 1994 Jun;266(6 Pt 2):H2468-75 [8024008] Circulation. 1995 Jan 1;91(1):161-70 [7805198] Hypertension. 1995 Jul;26(1):101-11 [7607712] Am J Physiol. 1995 Aug;269(2 Pt 2):H638-47 [7653628] J Mol Cell Cardiol. 1995 Nov;27(11):2483-94 [8596199] Circ Res. 1996 Apr;78(4):517-24 [8635208] J Mol Cell Cardiol. 1996 Aug;28(8):1817-22 [8877791] J Mol Cell Cardiol. 1997 Oct;29(10):2735-46 [9344768] Circulation. 1997 Dec 2;96(11):4002-10 [9403625] Am J Physiol. 1998 Mar;274(3 Pt 2):H868-73 [9530198] Am J Physiol. 1998 May;274(5 Pt 2):H1812-20 [9612394] J Mol Cell Cardiol. 1998 Jul;30(7):1443-7 [9710811] J Mol Cell Cardiol. 1998 Aug;30(8):1505-14 [9737937] Lab Anim Sci. 1998 Aug;48(4):374-8 [10090046] Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H30-6 [15749746] Hypertension. 2007 Apr;49(4):865-72 [17283249] J Mol Cell Cardiol. 2007 Apr;42(4):804-11 [17350036] Circ Res. 1973 Aug;33(2):233-43 [4269516] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. AN - 67591613; 19646280 AB - The selective MAO-B inhibitor selegiline has been evaluated in clinical trials as a potential medication for the treatment of cocaine dependence. This study evaluated the safety of and pharmacologic interactions between 7 days of transdermal selegiline dosed with patches (Selegiline Transdermal System, STS) that deliver 6 mg/24 hours and 2.5 mg/kg of cocaine administered over 4 hours. Twelve nondependent cocaine-experienced subjects received deuterium-labeled cocaine-d5 intravenously (IV) 0.5 mg/kg over 10 minutes followed by 2 mg/kg over 4 hours before and after one week of transdermal selegiline 6 mg/24 hours. Plasma and urine were collected for analysis of selegiline, cocaine, catecholamine and metabolite concentrations. Pharmacodynamic measures were obtained. Selegiline did not change cocaine pharmacokinetic parameters. Selegiline administration increased phenylethylamine (PEA) urinary excretion and decreased urinary MHPG-sulfate concentration after cocaine when compared to cocaine alone. No serious adverse effects occurred with the combination of selegiline and cocaine, and cocaine-induced physiological effects were unchanged after selegiline. Only 1 peak subjective cocaine effects rating changed, and only a few subjective ratings decreased across time after selegiline. No pharmacological interaction occurred between selegiline and a substantial dose of intravenous cocaine, suggesting the combination will be safe in pharmacotherapy trials. Selegiline produced few changes in subjective response to the cocaine challenge perhaps because of some psychoactive neurotransmitters changing in opposite directions. JF - BMC clinical pharmacology AU - Harris, Debra S AU - Everhart, Thomas AU - Jacob, Peyton AU - Lin, Emil AU - Mendelson, John E AU - Jones, Reese T AD - Department of Psychiatry, University of Cincinnati, OH, USA. debra.harris4@va.gov Y1 - 2009/08/01/ PY - 2009 DA - 2009 Aug 01 SP - 13 VL - 9 KW - Amphetamines KW - 0 KW - Dopamine Uptake Inhibitors KW - Monoamine Oxidase Inhibitors KW - Phenethylamines KW - 3-methoxy-4-hydroxyphenylglycol sulfate KW - 28700-49-4 KW - Selegiline KW - 2K1V7GP655 KW - phenethylamine KW - 327C7L2BXQ KW - Methamphetamine KW - 44RAL3456C KW - Methoxyhydroxyphenylglycol KW - 534-82-7 KW - benzoylecgonine KW - 5353I8I6YS KW - desmethylselegiline KW - 5F44WR1I53 KW - Prolactin KW - 9002-62-4 KW - Amphetamine KW - CK833KGX7E KW - Monoamine Oxidase KW - EC 1.4.3.4 KW - Cocaine KW - I5Y540LHVR KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Young Adult KW - Methoxyhydroxyphenylglycol -- urine KW - Analysis of Variance KW - Affect -- drug effects KW - Humans KW - Methoxyhydroxyphenylglycol -- analogs & derivatives KW - Monitoring, Physiologic KW - Homovanillic Acid -- blood KW - Phenethylamines -- urine KW - Adult KW - Amphetamines -- metabolism KW - Male KW - Amphetamine -- metabolism KW - Methoxyhydroxyphenylglycol -- metabolism KW - Administration, Cutaneous KW - Prolactin -- blood KW - Infusions, Intravenous KW - Homovanillic Acid -- metabolism KW - Drug Interactions -- physiology KW - Phenethylamines -- metabolism KW - Methamphetamine -- metabolism KW - Substance Withdrawal Syndrome -- psychology KW - Monoamine Oxidase -- metabolism KW - Female KW - Statistics, Nonparametric KW - Prolactin -- metabolism KW - Selegiline -- pharmacokinetics KW - Dopamine Uptake Inhibitors -- toxicity KW - Selegiline -- administration & dosage KW - Cocaine -- toxicity KW - Monoamine Oxidase Inhibitors -- administration & dosage KW - Cocaine -- administration & dosage KW - Monoamine Oxidase Inhibitors -- pharmacokinetics KW - Monoamine Oxidase Inhibitors -- pharmacology KW - Selegiline -- pharmacology KW - Cocaine -- analogs & derivatives KW - Cocaine -- pharmacokinetics KW - Dopamine Uptake Inhibitors -- pharmacokinetics KW - Cocaine -- metabolism KW - Cocaine -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67591613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+clinical+pharmacology&rft.atitle=A+phase+1+trial+of+pharmacologic+interactions+between+transdermal+selegiline+and+a+4-hour+cocaine+infusion.&rft.au=Harris%2C+Debra+S%3BEverhart%2C+Thomas%3BJacob%2C+Peyton%3BLin%2C+Emil%3BMendelson%2C+John+E%3BJones%2C+Reese+T&rft.aulast=Harris&rft.aufirst=Debra&rft.date=2009-08-01&rft.volume=9&rft.issue=&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=BMC+clinical+pharmacology&rft.issn=1472-6904&rft_id=info:doi/10.1186%2F1472-6904-9-13 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-16 N1 - Date created - 2009-08-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuropsychopharmacology. 2000 Oct;23(4):388-95 [10989265] Drug Alcohol Depend. 2001 Nov 1;64(3):271-83 [11672942] Psychopharmacology (Berl). 2001 Dec;159(1):21-30 [11797065] J Addict Dis. 2002;21(1):35-44 [11831498] Curr Med Chem. 2002 Jan;9(1):47-51 [11860347] Anal Chem. 2002 Oct 15;74(20):5290-6 [12403583] Synapse. 2003 Apr;48(1):35-8 [12557270] Biol Psychiatry. 2003 Nov 15;54(10):1099-104 [14625153] Drug Alcohol Depend. 2003 Nov 24;72(2):169-82 [14636972] Psychopharmacology (Berl). 2004 Feb;172(1):31-40 [14605792] Biochem Pharmacol. 1968 Jul;17(7):1285-97 [5659776] Pharmacol Biochem Behav. 1980 Oct;13(4):513-7 [6107935] Ann Emerg Med. 1982 Sep;11(9):482-4U [7114595] J Chromatogr. 1984 Jun 8;308:55-63 [6205011] Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(4-6):615-20 [6442439] Neurosci Biobehav Rev. 1985 Fall;9(3):469-77 [2999657] J Neurochem. 1987 Aug;49(2):522-7 [3110375] J Chromatogr. 1987 Jul 3;417(2):277-86 [3654881] J Neural Transm Gen Sect. 1990;80(1):51-65 [2407268] J Neural Transm Suppl. 1990;29:119-29 [2193105] J Neurochem. 1990 Dec;55(6):1827-37 [2172461] Life Sci. 1991;49(1):75-84 [1646924] Schizophr Bull. 1992;18(1):123-48 [1553492] Neurochem Res. 1993 Sep;18(9):1015-22 [7901780] Br J Psychiatry. 1993 Dec;163:815-6 [8306127] Drug Alcohol Depend. 1995 Jul;39(1):55-62 [7587975] Life Sci. 1996;59(14):1109-19 [8831798] J Pharmacol Exp Ther. 1996 Nov;279(2):524-38 [8930154] Neurology. 1996 Dec;47(6 Suppl 3):S137-45 [8959982] Biopharm Drug Dispos. 1997 Mar;18(2):165-84 [9099452] Science. 1997 Oct 3;278(5335):52-8 [9311926] Neuropsychopharmacology. 1999 Jun;20(6):582-90 [10327427] Drug Alcohol Depend. 2006 Dec 1;85(3):191-7 [16730924] Am J Ther. 1997 Sep-Oct;4(9-10):333-42 [10423628] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1472-6904-9-13 ER - TY - JOUR T1 - Neurocognitive characteristics of individuals with schizophrenia and cocaine dependence: comparison of currently dependent and remitted groups. AN - 67589349; 19684503 AB - Several investigations of cognitive functioning in individuals with schizophrenia and co-occurring cocaine use have yielded mixed results when compared with samples with schizophrenia only. However, no studies have specifically compared remitted and current cocaine dependence in schizophrenia. Such an analysis could help clarify the degree and type of cognitive impairment associated with cocaine dependence in schizophrenia. Two samples of individuals with schizophrenia - those with current cocaine dependence (n = 72) and those with cocaine dependence in remission (n = 48) were compared on a brief neuropsychological test battery. Parallel current dependent and remitted samples with affective disorder (n = 65 and n = 55) were also included in the analyses. Results yielded few neuropsychological differences between remitted and current dependent states across the SZ and AD groups. These findings suggest that cognitive impairment may be relatively static in these populations. JF - The Journal of nervous and mental disease AU - Peer, Jason AU - Bennett, Melanie E AU - Bellack, Alan S AD - Veterans Affairs Capitol Health Care Network Mental Illness, Research, Education, and Clinical Center, Baltimore, MD, USA. jason.peer@va.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 631 EP - 634 VL - 197 IS - 8 KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Psychiatric Status Rating Scales KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Schizophrenic Psychology KW - Longitudinal Studies KW - Psychometrics KW - Male KW - Female KW - Diagnostic and Statistical Manual of Mental Disorders KW - Comorbidity KW - Neuropsychological Tests -- statistics & numerical data KW - Cocaine-Related Disorders -- diagnosis KW - Cognition Disorders -- diagnosis KW - Cognition Disorders -- epidemiology KW - Cocaine-Related Disorders -- psychology KW - Schizophrenia -- diagnosis KW - Cocaine-Related Disorders -- epidemiology KW - Schizophrenia -- epidemiology KW - Cognition Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67589349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=Neurocognitive+characteristics+of+individuals+with+schizophrenia+and+cocaine+dependence%3A+comparison+of+currently+dependent+and+remitted+groups.&rft.au=Peer%2C+Jason%3BBennett%2C+Melanie+E%3BBellack%2C+Alan+S&rft.aulast=Peer&rft.aufirst=Jason&rft.date=2009-08-01&rft.volume=197&rft.issue=8&rft.spage=631&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=1539-736X&rft_id=info:doi/10.1097%2FNMD.0b013e3181b08bf4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-20 N1 - Date created - 2009-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychiatry Res. 2000 Feb 14;93(1):21-32 [10699225] Addict Behav. 2008 Aug;33(8):1021-30 [18485611] Curr Opin Neurobiol. 2001 Apr;11(2):250-7 [11301247] Drug Alcohol Depend. 2002 Apr 1;66(2):161-71 [11906803] J Nerv Ment Dis. 2002 Mar;190(3):200-2 [11923656] J Subst Abuse Treat. 2003 Jan;24(1):75-9 [12646333] J Nerv Ment Dis. 2003 May;191(5):300-8 [12819549] Schizophr Bull. 1990;16(1):31-56 [2333480] J Nerv Ment Dis. 1990 Oct;178(10):642-8 [2230749] JAMA. 1990 Nov 21;264(19):2511-8 [2232018] J Subst Abuse Treat. 1992;9(3):199-213 [1334156] Am J Psychiatry. 1993 May;150(5):758-62 [8480822] Am J Psychiatry. 1993 Sep;150(9):1355-62 [8352346] Arch Gen Psychiatry. 1997 Feb;54(2):159-65 [9040284] Addiction. 1997 Jun;92(6):747-59 [9246802] Drug Alcohol Depend. 1999 Mar 1;54(1):19-33 [10101614] Schizophr Res. 1999 Mar 1;35 Suppl:S93-100 [10190230] Psychiatry Res. 2004 Oct 30;128(3):209-18 [15541777] Psychiatr Serv. 2006 Aug;57(8):1110-6 [16870961] Biol Psychiatry. 2007 Jul 15;62(2):179-86 [17161829] Schizophr Res. 2008 Mar;100(1-3):242-51 [17614260] J Subst Abuse. 2000;11(2):205-13 [10989779] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/NMD.0b013e3181b08bf4 ER - TY - JOUR T1 - Characteristics of Bacteroides fragilis lacking the major outer membrane protein, OmpA. AN - 67538652; 19497947 AB - OmpA1 is the major outer membrane protein of the Gram-negative anaerobic pathogen Bacteroides fragilis. We identified three additional conserved ompA homologues (ompA2-ompA4) and three less homologous ompA-like genes (ompAs 5, 6 and 7) in B. fragilis. We constructed an ompA1 disruption mutant in B. fragilis 638R (WAL6 OmegaompA1) using insertion-mediated mutagenesis. WAL6 OmegaompA1 formed much smaller colonies and had smaller, rounder forms on Gram stain analysis than the parental strain or other unrelated disruption mutants. SDS-PAGE and Western blot analysis (with anti-OmpA1 IgY) of the OMP patterns of WAL6 OmegaompA1 grown in both high- and low-salt media did not reveal any other OmpA proteins even under osmotic stress. An ompA1 deletant (WAL186DeltaompA1) was constructed using a two-step double-crossover technique, and an ompA 'reinsertant', WAL360+ompA1, was constructed by reinserting the ompA gene into WAL186DeltaompA1. WAL186DeltaompA1 was significantly more sensitive to exposure to SDS, high salt and oxygen than the parental (WAL108) or reinsertant (WAL360+ompA1) strain. No significant change was seen in MICs of a variety of antimicrobials for either WAL6 OmegaompA1 or WAL186DeltaompA1 compared to WAL108. RT-PCR revealed that all of the ompA genes are transcribed in the parental strain and in the disruption mutant, but, as expected, ompA1 is not transcribed in WAL186DeltaompA1. Unexpectedly, ompA4 is also not transcribed in WAL186DeltaompA1. A predicted structure indicated that among the four OmpA homologues, the barrel portion is more conserved than the loops, except for specific conserved patches on loop 1 and loop 3. The presence of multiple copies of such similar genes in one organism would suggest a critical role for this protein in B. fragilis. JF - Microbiology (Reading, England) AU - Wexler, Hannah M AU - Tenorio, Elizabeth AU - Pumbwe, Lilian AD - Greater Los Angeles Veterans Administration Healthcare System, University of California, Los Angeles, CA 90073, USA. hwexler@ucla.edu Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 2694 EP - 2706 VL - 155 SN - 1350-0872, 1350-0872 KW - Anti-Infective Agents KW - 0 KW - Bacterial Outer Membrane Proteins KW - DNA, Bacterial KW - Protein Sorting Signals KW - OMPA outer membrane proteins KW - 149024-69-1 KW - Index Medicus KW - Phylogeny KW - Protein Structure, Secondary KW - Genome, Bacterial KW - Conserved Sequence KW - Anti-Infective Agents -- pharmacokinetics KW - Sequence Homology, Nucleic Acid KW - Molecular Sequence Data KW - Transcription, Genetic KW - Amino Acid Sequence KW - Stress, Physiological KW - Bacteroides fragilis -- physiology KW - Bacteroides fragilis -- drug effects KW - Bacterial Outer Membrane Proteins -- genetics KW - Bacterial Outer Membrane Proteins -- metabolism KW - Bacterial Outer Membrane Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67538652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology+%28Reading%2C+England%29&rft.atitle=Characteristics+of+Bacteroides+fragilis+lacking+the+major+outer+membrane+protein%2C+OmpA.&rft.au=Wexler%2C+Hannah+M%3BTenorio%2C+Elizabeth%3BPumbwe%2C+Lilian&rft.aulast=Wexler&rft.aufirst=Hannah&rft.date=2009-08-01&rft.volume=155&rft.issue=&rft.spage=2694&rft.isbn=&rft.btitle=&rft.title=Microbiology+%28Reading%2C+England%29&rft.issn=13500872&rft_id=info:doi/10.1099%2Fmic.0.025858-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-08 N1 - Date created - 2009-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1099/mic.0.025858-0 ER - TY - JOUR T1 - Evaluation of combination long-acting beta-2 agonists and inhaled glucocorticosteroids for treatment of asthma. AN - 67508335; 19619072 AB - Treating asthma with a combination of inhaled corticosteroid and a long-acting beta-2-agonist is often preferred when asthma is not controlled when using a low-medium dose of an inhaled corticosteroid. To review the pharmacology, efficacy and safety of inhalers containing combinations of long-acting bronchodilators and inhaled corticosteroids to treat moderate-to-severe, persistent asthma. Using a list of keywords, we conducted a PubMed search of the literature. Data provided by the manufacturer were also reviewed. Fluticasone propionate with salmeterol and budesonide with formoterol are both well tolerated, have equal clinical efficacy and have recent data affirming their safe use in diverse patient populations. Combination inhalers improve asthma control in patients previously uncontrolled on inhaled corticosteroids. JF - Expert opinion on drug metabolism & toxicology AU - Kim, Dennis AU - Glaum, Mark AU - Lockey, Richard AD - University of South Florida, James A Haley Veterans' Administration Hospital, College of Medicine, Division of Allergy and Clinical Immunology, Department of Internal Medicine, Tampa, Florida 33612, USA. dkim2@health.usf.edu Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 933 EP - 940 VL - 5 IS - 8 KW - Adrenergic beta-2 Receptor Agonists KW - 0 KW - Adrenergic beta-Agonists KW - Anti-Asthmatic Agents KW - Bronchodilator Agents KW - Drug Combinations KW - Glucocorticoids KW - Index Medicus KW - Animals KW - Bronchodilator Agents -- pharmacology KW - Humans KW - Bronchodilator Agents -- therapeutic use KW - Bronchodilator Agents -- pharmacokinetics KW - Bronchodilator Agents -- adverse effects KW - Administration, Inhalation KW - Glucocorticoids -- pharmacokinetics KW - Adrenergic beta-Agonists -- pharmacology KW - Asthma -- drug therapy KW - Adrenergic beta-Agonists -- adverse effects KW - Adrenergic beta-Agonists -- pharmacokinetics KW - Anti-Asthmatic Agents -- pharmacology KW - Anti-Asthmatic Agents -- therapeutic use KW - Glucocorticoids -- adverse effects KW - Glucocorticoids -- therapeutic use KW - Adrenergic beta-Agonists -- therapeutic use KW - Anti-Asthmatic Agents -- adverse effects KW - Glucocorticoids -- pharmacology KW - Anti-Asthmatic Agents -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67508335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Evaluation+of+combination+long-acting+beta-2+agonists+and+inhaled+glucocorticosteroids+for+treatment+of+asthma.&rft.au=Kim%2C+Dennis%3BGlaum%2C+Mark%3BLockey%2C+Richard&rft.aulast=Kim&rft.aufirst=Dennis&rft.date=2009-08-01&rft.volume=5&rft.issue=8&rft.spage=933&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=1744-7607&rft_id=info:doi/10.1517%2F17425250903127226 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-28 N1 - Date created - 2009-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/17425250903127226 ER - TY - JOUR T1 - Behavioral treatment of substance abuse in schizophrenia. AN - 67502205; 19551711 AB - Co-occurring substance use disorders are highly prevalent among individuals with schizophrenia and other serious and persistent mental illnesses (SPMI) and are associated with clinically significant consequences. A multifaceted behavioral treatment called Behavioral Treatment for Substance Abuse in Serious and Persistent Mental Illness (BTSAS) can reduce substance abuse in persons with SPMI. The key treatment strategies in BTSAS include a urinalysis contingency, short-term goal setting, training in drug refusal skills, psychoeducation about the impact of drug use, and relapse prevention training. A case example illustrating the application of BTSAS is presented and relevant clinical issues are discussed. JF - Journal of clinical psychology AU - Tenhula, Wendy N AU - Bennett, Melanie E AU - Strong Kinnaman, Joanna E AD - VA Capital Health Care Network Mental Illness Research, Education and Clinical Center, Baltimore, MD 21201, USA. wendy.tenhula@va.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 831 EP - 841 VL - 65 IS - 8 KW - Index Medicus KW - Humans KW - Middle Aged KW - Anecdotes as Topic KW - Male KW - Comorbidity KW - Schizophrenia KW - Cognitive Therapy -- methods KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67502205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Behavioral+treatment+of+substance+abuse+in+schizophrenia.&rft.au=Tenhula%2C+Wendy+N%3BBennett%2C+Melanie+E%3BStrong+Kinnaman%2C+Joanna+E&rft.aulast=Tenhula&rft.aufirst=Wendy&rft.date=2009-08-01&rft.volume=65&rft.issue=8&rft.spage=831&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=1097-4679&rft_id=info:doi/10.1002%2Fjclp.20613 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-04 N1 - Date created - 2009-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jclp.20613 ER - TY - JOUR T1 - Disposal of a 60Co self-shielded irradiator through the Department of Energy's Off-Site Source Recovery Project. AN - 67474722; 19590268 AB - An Atomic Energy of Canada Limited Gamma Cell 220 self-shielded irradiator acquired in 1974 by the VA Eastern Colorado Health Care System was disposed of through the Department of Energy's Off-Site Source Recovery Project in 2006. JF - Health physics AU - Vernig, Peter Graham AD - VA Eastern Colorado Health Care System, USA. peter.vernig@va.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - S145 EP - S150 VL - 97 IS - 2 Suppl KW - Cobalt Radioisotopes KW - 0 KW - Index Medicus KW - United States KW - Contract Services KW - United States Government Agencies KW - Radiation Protection KW - Radiation Equipment and Supplies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67474722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Disposal+of+a+60Co+self-shielded+irradiator+through+the+Department+of+Energy%27s+Off-Site+Source+Recovery+Project.&rft.au=Vernig%2C+Peter+Graham&rft.aulast=Vernig&rft.aufirst=Peter&rft.date=2009-08-01&rft.volume=97&rft.issue=2+Suppl&rft.spage=S145&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=1538-5159&rft_id=info:doi/10.1097%2FHP.0b013e3181a9441e LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-12 N1 - Date created - 2009-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/HP.0b013e3181a9441e ER - TY - JOUR T1 - Introduction to a Special Edition: Attachment Theory and its Application to Practice AN - 61389842; 200908361 AB - Although the form, scope, & function of the basic family unit have changed dramatically during the past one hundred years, the important role of the family unit as the foundation for personality development among its members still predominates. Attachment theory has evolved into a leading developmental & social personality model that stresses the importance of the primary caregiver-child relationship within family units. Bowlby (1984) proposed that infant attachment relationships provide the context in which working models of self & other are formed & that these working models play a key role in affect regulation & personality development. Ainsworth et al. (1978) developed a procedure, based on Bowlby's (1969/1982) model of attachment, called the "Strange Situation", to measure the quality of a child's attachment relationship with his or her parents (or primary caregivers). According to attachment theory, a felt sense of security in the attachment relationship offers the infants a "secure base" from which to explore the environment & a safe haven in times of uncertainty. Adapted from the source document. JF - Child and Adolescent Social Work Journal AU - Fairchild, Sherry R AD - Psychosocial Psychiatric Rehabilitation, Central Texas Veteran's Affairs Health Care System, Waco-VA Medical Center, BD 7, 1B-104, Waco, TX, USA Sherry.Fairchild@va.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 287 EP - 289 PB - Springer, Dordrecht, The Netherlands VL - 26 IS - 4 SN - 0738-0151, 0738-0151 KW - Attachment KW - Clinical Social Work KW - Child Development KW - Psychological Theories KW - Parent Child Relations KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61389842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+and+Adolescent+Social+Work+Journal&rft.atitle=Introduction+to+a+Special+Edition%3A+Attachment+Theory+and+its+Application+to+Practice&rft.au=Fairchild%2C+Sherry+R&rft.aulast=Fairchild&rft.aufirst=Sherry&rft.date=2009-08-01&rft.volume=26&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Child+and+Adolescent+Social+Work+Journal&rft.issn=07380151&rft_id=info:doi/10.1007%2Fs10560-009-0178-9 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 18 N1 - Last updated - 2016-09-28 N1 - CODEN - CASWDD N1 - SubjectsTermNotLitGenreText - Attachment; Parent Child Relations; Child Development; Psychological Theories; Clinical Social Work DO - http://dx.doi.org/10.1007/s10560-009-0178-9 ER - TY - JOUR T1 - Attachment Representations and Parental Memories of Incarcerated Fathers AN - 61369311; 200908360 AB - This article presents the findings of a study designed to apply attachment theory concepts to a group of incarcerated fathers in a minimum-security facility. Participants in this convenience sample were either immediate graduates of a 13-week parenting skills program or currently involved in the parenting skills program. This exploratory study sought to examine first, whether the Adult Attachment Interview (AAI) could effectively determine current mental representations of attachment relationships with a group of incarcerated fathers. Secondly, to gain further knowledge of this population regarding the impact of familial aspects by use of a survey measure, along with two other standardized measures were implemented. Thirty-eight voluntary subjects participated in the intensive AAI in scheduled individual sessions, completing child abuse additional measures. Differences among a three-category adult attachment classifications and five-category attachment classifications were identified. Both qualitative and quantitative results are discussed. Adapted from the source document. JF - Child and Adolescent Social Work Journal AU - Fairchild, Sherry R AD - Psychosocial Psychiatric Rehabilitation at Department of Veterans Affairs, Central Texas VA Healthcare System, 4800 Memorial Drive, Waco, TX, 76711, USA Sherry.Fairchild@va.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 361 EP - 377 PB - Springer, Dordrecht, The Netherlands VL - 26 IS - 4 SN - 0738-0151, 0738-0151 KW - Parent Training KW - Imprisonment KW - Attachment KW - Father Absence KW - Parent Child Relations KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61369311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+and+Adolescent+Social+Work+Journal&rft.atitle=Attachment+Representations+and+Parental+Memories+of+Incarcerated+Fathers&rft.au=Fairchild%2C+Sherry+R&rft.aulast=Fairchild&rft.aufirst=Sherry&rft.date=2009-08-01&rft.volume=26&rft.issue=4&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Child+and+Adolescent+Social+Work+Journal&rft.issn=07380151&rft_id=info:doi/10.1007%2Fs10560-009-0180-2 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 31 N1 - Last updated - 2016-09-28 N1 - CODEN - CASWDD N1 - SubjectsTermNotLitGenreText - Father Absence; Parent Child Relations; Attachment; Imprisonment; Parent Training DO - http://dx.doi.org/10.1007/s10560-009-0180-2 ER - TY - JOUR T1 - An Investigation of Posttraumatic Stress Disorder and Depressive Symptomatology among Female Victims of Interpersonal Trauma AN - 61361932; 200908120 AB - This study examined factors associated with PTSD-depression comorbidity among a sample of 162 adult female rape or assault victims with PTSD, as well as potential differential predictors of PTSD and depression severity. PTSD-only participants reported higher levels of childhood sexual abuse than those with comorbid PTSD and depression, and the PTSD/MDD group reported relatively more distorted trauma-related beliefs, dissociation, PTSD severity, and depression severity. Distorted trauma-related beliefs and dissociation were the strongest unique predictors of higher PTSD and depressive symptoms. Rates of PTSD and depression comorbidity did not appear to be a function of symptom overlap. Study findings suggest possible explanations for the high PTSD and depression comorbidity rates commonly found among victims of interpersonal violence. Adapted from the source document. JF - Journal of Family Violence AU - Taft, Casey T AU - Resick, Patricia A AU - Watkins, Laura E AU - Panuzio, Jillian AD - National Center for PTSD, VA Boston Healthcare System (116B-2), 150 South Huntington Avenue, Boston, MA, 02130, USA casey.taft@med.va.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 407 EP - 415 PB - Springer Science+Business Media, Inc, New York, NY VL - 24 IS - 6 SN - 0885-7482, 0885-7482 KW - Rape KW - Partner Abuse KW - Depression (Psychology) KW - Victims KW - Assault KW - Females KW - Posttraumatic Stress Disorder KW - Trauma KW - Child Sexual Abuse KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61361932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Violence&rft.atitle=An+Investigation+of+Posttraumatic+Stress+Disorder+and+Depressive+Symptomatology+among+Female+Victims+of+Interpersonal+Trauma&rft.au=Taft%2C+Casey+T%3BResick%2C+Patricia+A%3BWatkins%2C+Laura+E%3BPanuzio%2C+Jillian&rft.aulast=Taft&rft.aufirst=Casey&rft.date=2009-08-01&rft.volume=24&rft.issue=6&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Violence&rft.issn=08857482&rft_id=info:doi/10.1007%2Fs10896-009-9243-6 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 52 N1 - Last updated - 2016-09-28 N1 - CODEN - JFVIEV N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Depression (Psychology); Child Sexual Abuse; Victims; Females; Assault; Rape; Partner Abuse; Trauma DO - http://dx.doi.org/10.1007/s10896-009-9243-6 ER - TY - JOUR T1 - Posttraumatic Stress Disorder Symptoms, Relationship Adjustment, and Relationship Aggression in a Sample of Female Flood Victims AN - 59975546; 200946810 AB - This study tested a model examining the interrelationships among posttraumatic stress disorder (PTSD) symptoms, intimate relationship adjustment, and intimate relationship aggression in a sample of 205 adult female flood victims. At the bivariate level, higher PTSD symptoms were associated with higher physical and psychological aggression victimization, poorer relationship adjustment, and higher physical and psychological aggression perpetration. Results from structural equation modeling (SEM) analyses indicated that relationship aggression victimization influenced aggression perpetration directly, and in the case of physical aggression, indirectly through its relationship with PTSD symptoms and relationship adjustment. The influence of PTSD symptoms on physical aggression perpetration was fully explained by poorer relationship adjustment. These findings extend prior work from other traumatized populations documenting associations between variables reflecting PTSD symptomatology and indices of relationship functioning, and indicate a need for further investigation in this area of inquiry. Adapted from the source document. JF - Journal of Family Violence AU - Taft, Casey T AU - Monson, Candice M AU - Schumm, Jeremiah A AU - Watkins, Laura E AU - Panuzio, Jillian AU - Resick, Patricia A AD - National Center for PTSD, VA Boston Healthcare System (116B-2), 150 South Huntington Avenue, Boston, MA, 02130, USA casey.taft@med.va.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 389 EP - 396 PB - Springer Science+Business Media, Inc, New York, NY VL - 24 IS - 6 SN - 0885-7482, 0885-7482 KW - Symptoms KW - Victims KW - Females KW - Aggression KW - Posttraumatic Stress Disorder KW - Adjustment KW - Victimization KW - article KW - 2190: social problems and social welfare; victimology (rape, family violence, & child abuse) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59975546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Violence&rft.atitle=Posttraumatic+Stress+Disorder+Symptoms%2C+Relationship+Adjustment%2C+and+Relationship+Aggression+in+a+Sample+of+Female+Flood+Victims&rft.au=Taft%2C+Casey+T%3BMonson%2C+Candice+M%3BSchumm%2C+Jeremiah+A%3BWatkins%2C+Laura+E%3BPanuzio%2C+Jillian%3BResick%2C+Patricia+A&rft.aulast=Taft&rft.aufirst=Casey&rft.date=2009-08-01&rft.volume=24&rft.issue=6&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Violence&rft.issn=08857482&rft_id=info:doi/10.1007%2Fs10896-009-9241-8 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 36 N1 - Last updated - 2016-09-28 N1 - CODEN - JFVIEV N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Aggression; Adjustment; Victims; Victimization; Females; Symptoms DO - http://dx.doi.org/10.1007/s10896-009-9241-8 ER - TY - JOUR T1 - Treatment Presentation and Adherence of Iraq/Afghanistan Era Veterans in Outpatient Care for Posttraumatic Stress Disorder AN - 57311774; 200924971 AB - The ongoing wars in Afghanistan (Operation Enduring Freedom or OEF) and Iraq (Operation Iraqi Freedom or OIF) make the development and application of effective postdeployment mental health treatment programs a high priority. There has been some concern that existing treatment programs for combat-related posttraumatic stress disorder (PTSD) may not fit well with OEF/OIF veterans confronted with acute mental health difficulties while reestablishing community, familial, and occupational connections after their deployment. This study utilized data gathered from a large outpatient Veterans Affairs Medical Center PTSD treatment clinic to examine differences in initial treatment presentation and treatment adherence (attendance and dropout) between a group of Vietnam era veterans (n = 54) and a group of OEF/OIF veterans (n = 106). OEF/OIF veterans reported lower levels of symptom distress on questionnaires assessing posttraumatic reexperiencing, avoidance, dissociation, and arousal symptoms but similar levels of anger and acting out behaviors and higher levels of alcohol problems. OEF/OIF veterans had significantly lower rates of session attendance and higher rates of treatment dropout than Vietnam veterans, and this difference was not accounted for by differences in treatment presentation. [Copyright Elsevier B.V.] JF - Psychological Services AU - Erbes, Christopher R AU - Curry, Kyle T AU - Leskela, Jennie AD - Minneapolis VA Medical Center christopher.erbes@va.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 175 EP - 183 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 6 IS - 3 SN - 1541-1559, 1541-1559 KW - posttraumatic stress disorder treatment adherence Vietnam combat veterans Iraq/Afghanistan combat veterans KW - Veterans KW - Symptoms KW - Posttraumatic stress disorder KW - Freedom KW - Afghanistan KW - Treatment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57311774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Treatment+Presentation+and+Adherence+of+Iraq%2FAfghanistan+Era+Veterans+in+Outpatient+Care+for+Posttraumatic+Stress+Disorder&rft.au=Erbes%2C+Christopher+R%3BCurry%2C+Kyle+T%3BLeskela%2C+Jennie&rft.aulast=Erbes&rft.aufirst=Christopher&rft.date=2009-08-01&rft.volume=6&rft.issue=3&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0016662 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-10-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Veterans; Posttraumatic stress disorder; Afghanistan; Freedom; Symptoms; Treatment DO - http://dx.doi.org/10.1037/a0016662 ER - TY - JOUR T1 - Potential Unintended Consequences of Tobacco-Control Policies on Mothers Who Smoke: A Review of the Literature AN - 57304904; 200921518 AB - Secondhand smoke poses risks to children, particularly those from low socioeconomic backgrounds. Recently, there has been an increase in tobacco-control policies designed to reduce children's exposure to secondhand smoke, including interventions to change parental smoking behaviors. However, little attention has been paid to understanding potential unintended consequences of such initiatives on mothers who smoke. As such, the objectives of this paper are to explore the potential consequences of tobacco-control policies designed to reduce children's exposure to secondhand smoke on socially disadvantaged mothers who smoke and to provide recommendations for research, policy, and practice. Evidence acquisition A theory-guided, qualitative narrative review of the perceived discrimination, stigma, and stress and coping literature was conducted. MEDLINE and PsycINFO were searched to identify relevant articles from 1980 to October 2008 for review. Evidence synthesis There is evidence that strategies designed to reduce secondhand smoke have contributed to smoking stigmatization. However, there is little research on the consequences of these initiatives or how they affect low-income mothers who smoke. Stigmatization research suggests that such policies may have unanticipated outcomes for socially disadvantaged mothers who smoke, such as decreased mental health; increased use of cigarettes or alcohol; avoidance or delay in seeking medical care; and poorer treatment by healthcare professionals. Recommendations for researchers, practitioners, and policymakers are presented. Conclusions Further research is needed to understand how initiatives to reduce children's exposure to secondhand smoke, as well as broader tobacco-control initiatives, can be designed to minimize potential harm to mothers who smoke. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Burgess, Diana J AU - Fu, Steven S AU - van Ryn, Michelle AD - Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota diana.burgess@va.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - S151 EP - S158 PB - Elsevier Science, New York NY VL - 37 IS - 2S1 SN - 0749-3797, 0749-3797 KW - Smoking KW - Stigmatization KW - Passive smoking KW - Mothers KW - Children KW - Disadvantaged mothers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57304904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Potential+Unintended+Consequences+of+Tobacco-Control+Policies+on+Mothers+Who+Smoke%3A+A+Review+of+the+Literature&rft.au=Burgess%2C+Diana+J%3BFu%2C+Steven+S%3Bvan+Ryn%2C+Michelle&rft.aulast=Burgess&rft.aufirst=Diana&rft.date=2009-08-01&rft.volume=37&rft.issue=2S1&rft.spage=S151&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2009.05.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Passive smoking; Children; Mothers; Stigmatization; Smoking; Disadvantaged mothers DO - http://dx.doi.org/10.1016/j.amepre.2009.05.006 ER - TY - JOUR T1 - Context and renewal of conditioned fear: An experimental evaluation using 20% carbon dioxide-enriched air as an unconditioned stimulus AN - 57285377; 200914635 AB - This analogue experiment used fear conditioning and extinction procedures to establish and reduce fearful responding and then test for fear renewal following a context change. Healthy undergraduates (N = 61) underwent a differential fear conditioning procedure using geometric shapes as conditioned stimuli (CS) and inhalations of 20% CO2-enriched air as an aversive unconditioned stimulus (US). Across phases (i.e., habituation, acquisition, extinction, and test), red and green ambient lighting served as contextual stimuli, and electrodermal and evaluative ratings were assessed as indices of conditioned fear. The control group underwent extinction and test phases under identical conditions (i.e., no context changes). The experimental groups either underwent acquisition and test phases in one context and the intervening extinction phase in a different context (A-B-A), or underwent acquisition and extinction phases in one context and the test phase in a novel context (A-A-B). Consistent with expectation, fear renewal was observed when the test context matched the acquisition context. This effect was modest for electrodermal responses, but reasonably robust for evaluative responses. The role of context in the subsequent renewal of fear following exposure-based treatment is discussed. [Copyright Elsevier B.V.] JF - Journal of Anxiety Disorders AU - Finlay, Carlos G AU - Forsyth, John P AD - University at Albany, State University of New York, United States carlos.finlay@va.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 737 EP - 745 PB - Elsevier Ltd, The Netherlands VL - 23 IS - 6 SN - 0887-6185, 0887-6185 KW - Anxiety Fear renewal Context Fear conditioning Exposure therapy KW - Conditioning KW - Extinction KW - Fear KW - Stimulus KW - Psychological extinction KW - Renewal KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57285377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Anxiety+Disorders&rft.atitle=Context+and+renewal+of+conditioned+fear%3A+An+experimental+evaluation+using+20%25+carbon+dioxide-enriched+air+as+an+unconditioned+stimulus&rft.au=Finlay%2C+Carlos+G%3BForsyth%2C+John+P&rft.aulast=Finlay&rft.aufirst=Carlos&rft.date=2009-08-01&rft.volume=23&rft.issue=6&rft.spage=737&rft.isbn=&rft.btitle=&rft.title=Journal+of+Anxiety+Disorders&rft.issn=08876185&rft_id=info:doi/10.1016%2Fj.janxdis.2009.02.014 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Fear; Renewal; Extinction; Psychological extinction; Conditioning; Stimulus DO - http://dx.doi.org/10.1016/j.janxdis.2009.02.014 ER - TY - JOUR T1 - Changes in reported physical health symptoms and social function with prolonged exposure therapy for chronic posttraumatic stress disorder AN - 21114361; 11312076 AB - Background: Postraumatic stress disorder (PTSD) is associated with significant health risk, illness, and functional impairment, e.g., Green and Kimerling [2004: Physical Health Consequences of Exposure to Extreme Stress. Washington, DC: American Phychological Association] Kimerling et al. [2000: Trauma and Health: J Trauma Stress 13:115-128]. Methods: These analyses examined whether negative health perceptions and general social functioning change with treatment of chronic PTSD among women from a randomized controlled study comparing prolonged exposure (PE; n=48) or PE combined with cognitive restructuring (PE/CR; n=40) to waitlist (n=19; Foa et al., 2005: J Consult Clin Psychol 73:953-964]. Results: Self- reported physical health difficulties were significantly reduced in the PE and PE/CR conditions compared to the waitlist condition. These reductions did not demonstrate significant change during the 12 month follow-up period. Self-reported discomfort associated with physical health difficulties did not demonstrate significant change over treatment. No difference was detected between the active treatment and waitlist conditions. Both the PE and PE/CR groups reported improved social functioning at post treatment compared to the waitlist. Additional improvement in general social functioning was found between 3 and 12 month follow-up assessments. Changes in PTSD and depressive symptoms over treatment accounted for 29% of the variance in reduction of reported health problems and 30% of the variance in improvement of general social functioning. Importantly, only changes in PTSD symptoms significantly contribute to the model predicting change in physical health problems with depression associated only at a trend level. However, collinearity between PTSD and depression makes interpretation difficult. Conclusions: Negative health perceptions and general social function improve with PE. Changes in depression and PTSD with treatment are related to these changes. Depression and Anxiety, 2009. JF - Depression and Anxiety (Hoboken) AU - Rauch, Sheila A M AU - Grunfeld, Tania E E AU - Grad Dip Ed Psych AU - Yadin, Elna AU - Cahill, Shawn P AU - Hembree, Elizabeth AU - Foa, Edna B AD - Veterans Administration Ann Arbor Healthcare System, Ann Arbor, Michigan, sherauch@med.umich.edu Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 732 EP - 738 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 26 IS - 8 SN - 1091-4269, 1091-4269 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Risk assessment KW - Depression KW - posttraumatic stress disorder KW - Anxiety KW - Psychology KW - Stress KW - depression KW - Post-traumatic stress disorder KW - Trauma KW - Social interactions KW - Models KW - health problems KW - Perception KW - Cognitive ability KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21114361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+Anxiety+%28Hoboken%29&rft.atitle=Changes+in+reported+physical+health+symptoms+and+social+function+with+prolonged+exposure+therapy+for+chronic+posttraumatic+stress+disorder&rft.au=Rauch%2C+Sheila+A+M%3BGrunfeld%2C+Tania+E+E%3BGrad+Dip+Ed+Psych%3BYadin%2C+Elna%3BCahill%2C+Shawn+P%3BHembree%2C+Elizabeth%3BFoa%2C+Edna+B&rft.aulast=Rauch&rft.aufirst=Sheila+A&rft.date=2009-08-01&rft.volume=26&rft.issue=8&rft.spage=732&rft.isbn=&rft.btitle=&rft.title=Depression+and+Anxiety+%28Hoboken%29&rft.issn=10914269&rft_id=info:doi/10.1002%2Fda.20518 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Depression; Anxiety; Cognitive ability; Perception; Stress; Post-traumatic stress disorder; Models; Social interactions; Trauma; Risk assessment; health problems; posttraumatic stress disorder; Psychology; depression DO - http://dx.doi.org/10.1002/da.20518 ER - TY - JOUR T1 - Predictors and Outcomes of Antibiotic Adequacy for Bloodstream Infections in Veterans With Spinal Cord Injury AN - 20799644; 10897126 AB - Evans CT, Burns SP, Chin A, Weaver FM, Hershow RC. Predictors and outcomes of antibiotic adequacy for bloodstream infections in veterans with spinal cord injury. Objective - To identify predictors and outcomes associated with receiving inadequate empirical antimicrobial treatment for bloodstream infections (BSIs) in persons with spinal cord injury (SCI). Design - Retrospective cohort study from October 1, 1997, through September 30, 2004. Setting - A Department of Veterans Affairs SCI center that serves approximately 700 patients a year. Participants - Hospitalized patients with SCI (N=123) who had 1 or more,Is during the study period. Interventions - Not applicable. Main Outcome Measures - Adequacy of antimicrobial treatment (inadequate treatment was defined as the absence of antimicrobial agents for a particular organism within 2 days after the collection of blood cultures and/or the microorganism's resistance to the antimicrobial administered), hospital length of stay (LOS) post-BSI infection, and in-hospital and 30-day mortality. Cluster-adjusted multivariable models were assessed. Results - Over one third (88; 37.4%) of the 235 episodes of,I identified received inadequate empirical antibiotic treatment. Having a polymicrobial,I was associated with inadequate treatment (odds ratio [OR]=3.28; 95% confidence interval [CI]=1.62-6.65; P=.001). Factors protective against inadequate therapy included having a comorbid pressure ulcer (OR=0.37; 95% CI=0.21-0.68; P=.001) or a,I that was not primary (OR=0.30; 95% CI=0.15-0.58; P<.0001). Mortality did not differ between the inadequate and adequate treatment groups (11.4% vs 10.9%; P=.92). Similarly LOS postinfection was not affected by treatment status (inadequate treatment median=22d vs adequate treatment median=27d; P=.98). Conclusions - Over one third of patients received inadequate empirical treatment, which was associated with having a polymicrobial,I. However, inadequate treatment was not associated with increased mortality or LOS postinfection. JF - Archives of Physical Medicine and Rehabilitation AU - Evans, Charlesnika T AU - Burns, Stephen P AU - Chin, Amy AU - Weaver, Frances M AU - Hershow, Ronald C AD - Department of Veterans Affairs, Spinal Cord Injury Quality Enhancement Research Initiative, Center for Management of Complex Chronic Care, Edward Hines Jr Veterans Affairs Hospital, Hines, IL, Charlesnika.Evans@va.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1364 EP - 1370 PB - Elsevier BV, The Curtis Center, Independence Square West Philadelphia PA 19106-3399 USA VL - 90 IS - 8 SN - 0003-9993, 0003-9993 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bacteremia KW - Drug resistance KW - Drug therapy KW - Rehabilitation KW - Spinal cord injuries KW - Burns KW - Blood culture KW - Mortality KW - Antibiotics KW - Spinal cord injury KW - Infection KW - Substance P KW - Models KW - Antimicrobial agents KW - Ulcers KW - Jaw KW - Pressure KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20799644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Predictors+and+Outcomes+of+Antibiotic+Adequacy+for+Bloodstream+Infections+in+Veterans+With+Spinal+Cord+Injury&rft.au=Evans%2C+Charlesnika+T%3BBurns%2C+Stephen+P%3BChin%2C+Amy%3BWeaver%2C+Frances+M%3BHershow%2C+Ronald+C&rft.aulast=Evans&rft.aufirst=Charlesnika&rft.date=2009-08-01&rft.volume=90&rft.issue=8&rft.spage=1364&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/10.1016%2Fj.apmr.2009.02.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Blood culture; Burns; Mortality; Rehabilitation; Antibiotics; Spinal cord injury; Infection; Substance P; Antimicrobial agents; Models; Ulcers; Jaw; Pressure; Hospitals DO - http://dx.doi.org/10.1016/j.apmr.2009.02.012 ER - TY - JOUR T1 - Differential gene expression in Streptococcus pneumoniae in response to various iron sources AN - 20169170; 10135589 AB - Iron is a critical co-factor for several enzymes and is known to regulate gene expression in many pathogens. Streptococcus pneumoniae (pneumococcus) normally colonizes the upper respiratory mucosa, which is an iron-restricted environment. In contrast, during bacteremia available iron from heme and non-heme proteins potentially increases. In iron-depleted medium pneumococcal strain TIGR4 showed reduced growth, however, addition of several physiological iron sources restored growth. Gene expression of selected known and putative pneumococcal virulence factors was analyzed by quantitative RT-PCR in response to iron sources in vitro and during colonization, pneumonia, and bacteremia in a mouse model. Change in mRNA levels relative to transcription in iron-depleted medium was reported. In presence of iron sources, transcription of cps4A, zmpA, pavA, hemolysin and a putative exfoliative toxin was significantly increased, but nanB was suppressed. Hemoglobin at physiological concentration repressed ply and pspA expression. Ferritin, an acute phase protein, increased expression of an iron ABC transporter and repressed expression of a bacterial non-heme iron-containing ferritin. Transcription of cps4A, nanB, hemolysin, and a putative exfoliative toxin were significantly up-regulated during pneumonia and bacteremia, while mRNA of pavA and non-heme ferritin were expressed at higher levels during pneumonia and carriage. An iron ABC transporter was most up-regulated during bacteremia, while pspA and ply were expressed only in pneumonia. Transcription of zmpA was elevated during both pneumonia and bacteremia. These findings suggest that a subset of virulence genes in pneumococci is differentially regulated in response to the quantity and form of iron sources available in a host. JF - Microbial Pathogenesis AU - Gupta, R AU - Shah, P AU - Swiatlo, E AD - University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA, edwin.swiatlo@va.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 101 EP - 109 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 47 IS - 2 SN - 0882-4010, 0882-4010 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - ABC transporter KW - Acute phase substances KW - Animal models KW - Bacteremia KW - Colonization KW - Enzymes KW - Ferritin KW - Gene expression KW - Heme KW - Hemoglobin KW - Hemolysins KW - Iron KW - Mucosa KW - Pathogens KW - Pneumonia KW - Polymerase chain reaction KW - PspA protein KW - Toxins KW - Transcription KW - virulence factors KW - Streptococcus pneumoniae KW - J 02410:Animal Diseases KW - A 01450:Environmental Pollution & Waste Treatment KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20169170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Differential+gene+expression+in+Streptococcus+pneumoniae+in+response+to+various+iron+sources&rft.au=Gupta%2C+R%3BShah%2C+P%3BSwiatlo%2C+E&rft.aulast=Gupta&rft.aufirst=R&rft.date=2009-08-01&rft.volume=47&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1016%2Fj.micpath.2009.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2012-12-14 N1 - SubjectsTermNotLitGenreText - PspA protein; Heme; virulence factors; ABC transporter; Mucosa; Animal models; Bacteremia; Transcription; Enzymes; Pathogens; Toxins; Gene expression; Hemoglobin; Acute phase substances; Colonization; Polymerase chain reaction; Ferritin; Iron; Hemolysins; Pneumonia; Streptococcus pneumoniae DO - http://dx.doi.org/10.1016/j.micpath.2009.05.003 ER - TY - JOUR T1 - Tract-Based Spatial Statistics (TBSS) of diffusion tensor imaging data in alcohol dependence: abnormalities of the motivational neurocircuitry. AN - 67317947; 19442492 AB - Previous diffusion tensor imaging (DTI) studies indicated microstructural disruption of white matter in alcohol dependence. To investigate the microstructure of primary neurocircuitry involved in alcohol use disorders, the present study used Tract-Based Spatial Statistics (TBSS) of DTI measures as well as probabilistic tractography. Eleven recovering alcoholics in their first week of abstinence from alcohol were compared with 10 light-drinking controls; diffusion measures were correlated with measures of neurocognition and drinking severity. Regions characterized by low fractional anisotropy and high mean diffusivity included cortico-striatal fibers and those in frontal white matter and limbic pathways. Greater diffusion abnormalities in sections of commissural fibers (inter-hemispheric connections) were associated with greater drinking severity, and lower fractional anisotropy measures in frontal and limbic fiber tracts correlated with lower visuospatial memory performance. These study findings provide direct evidence of compromised integrity of the motivational brain circuitry in alcohol use disorders. These abnormalities in fiber connections could be partially responsible for deficiencies in executive functions, behavioral regulation, and impulse control commonly described in alcohol dependence. JF - Psychiatry research AU - Yeh, Ping-Hong AU - Simpson, Ken AU - Durazzo, Timothy C AU - Gazdzinski, Stefan AU - Meyerhoff, Dieter J AD - Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, San Francisco, CA 94121, USA. ping-hong_yeh@med.unc.edu Y1 - 2009/07/15/ PY - 2009 DA - 2009 Jul 15 SP - 22 EP - 30 VL - 173 IS - 1 SN - 0165-1781, 0165-1781 KW - Index Medicus KW - Severity of Illness Index KW - Alcohol Drinking -- pathology KW - Anisotropy KW - Humans KW - Neural Pathways -- pathology KW - Memory KW - Frontal Lobe -- pathology KW - Cerebral Cortex -- pathology KW - Adult KW - Alcohol Drinking -- psychology KW - Space Perception KW - Middle Aged KW - Corpus Striatum -- pathology KW - Neuropsychological Tests KW - Image Processing, Computer-Assisted KW - Visual Perception KW - Male KW - Diffusion Magnetic Resonance Imaging KW - Motivation KW - Brain -- pathology KW - Cognition KW - Alcohol-Related Disorders -- psychology KW - Alcohol-Related Disorders -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67317947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Tract-Based+Spatial+Statistics+%28TBSS%29+of+diffusion+tensor+imaging+data+in+alcohol+dependence%3A+abnormalities+of+the+motivational+neurocircuitry.&rft.au=Yeh%2C+Ping-Hong%3BSimpson%2C+Ken%3BDurazzo%2C+Timothy+C%3BGazdzinski%2C+Stefan%3BMeyerhoff%2C+Dieter+J&rft.aulast=Yeh&rft.aufirst=Ping-Hong&rft.date=2009-07-15&rft.volume=173&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/10.1016%2Fj.pscychresns.2008.07.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-19 N1 - Date created - 2009-06-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Magn Reson Med. 2003 Nov;50(5):1077-88 [14587019] Neuroimage. 2003 Nov;20(3):1714-22 [14642481] Magn Reson Med. 2004 Apr;51(4):807-15 [15065255] Neurochem Int. 2004 Sep;45(4):569-82 [15186924] Neuroimage. 2004;23 Suppl 1:S208-19 [15501092] IEEE Trans Med Imaging. 1999 Aug;18(8):712-21 [10534053] Psychopharmacology (Berl). 1999 Oct;146(4):373-90 [10550488] J Neurol Neurosurg Psychiatry. 2000 Aug;69(2):269-72 [10896709] Alcohol Clin Exp Res. 2000 Aug;24(8):1214-21 [10968660] Magn Reson Med. 2001 Feb;45(2):191-5 [11180424] J Neurol Sci. 2001 May 1;186 Suppl 1:S15-23 [11334986] Neuroimage. 2001 Jun;13(6 Pt 1):1174-85 [11352623] Hum Brain Mapp. 2002 Jan;15(1):1-25 [11747097] Neuroimage. 2002 Mar;15(3):708-18 [11848714] Brain. 2006 Mar;129(Pt 3):564-83 [16399806] Biol Psychiatry. 2006 Feb 15;59(4):364-72 [16125148] Neurobiol Aging. 2006 Jul;27(7):994-1009 [15964101] Neuroimage. 2006 Jul 15;31(4):1487-505 [16624579] Brain. 2006 Jul;129(Pt 7):1859-71 [16672290] Trends Mol Med. 2006 Dec;12(12):559-66 [17070107] Brain. 2007 Jan;130(Pt 1):48-64 [16959813] Drug Alcohol Rev. 2007 Jan;26(1):33-9 [17364834] Neuroimage. 2007 May 15;36(1):19-27 [17398118] Front Biosci. 2007;12:4079-100 [17485360] Arch Gen Psychiatry. 2007 Jul;64(7):830-42 [17606817] Neuroimage. 2007 Jul 15;36(4):1123-38 [17532649] Drug Alcohol Depend. 2007 Dec 1;91(2-3):195-204 [17644276] Neuroimaging Clin N Am. 2002 Feb;12(1):1-19 [11998247] Neuroimage. 2002 Oct;17(2):825-41 [12377157] Neuroimage. 2002 Nov;17(3):1429-36 [12414282] Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16192-6 [12451179] NMR Biomed. 2002 Nov-Dec;15(7-8):435-55 [12489094] Magn Reson Med. 2003 Jan;49(1):177-82 [12509835] Neurobiol Learn Mem. 2002 Nov;78(3):610-24 [12559839] Eur J Radiol. 2003 Mar;45(3):244-55 [12595109] Alcohol Clin Exp Res. 2003 Feb;27(2):301-9 [12605080] Hum Brain Mapp. 2003 Apr;18(4):306-21 [12632468] Am J Psychiatry. 2003 Jun;160(6):1041-52 [12777258] Nat Neurosci. 2003 Jul;6(7):750-7 [12808459] Alcohol Clin Exp Res. 2003 Sep;27(9):1409-19 [14506401] J Stud Alcohol. 1982 Nov;43(11):1157-70 [7182675] Can J Neurol Sci. 1984 Nov;11(4):441-6 [6518426] Psychol Bull. 1989 Jul;106(1):128-47 [2667007] Br J Addict. 1991 May;86(5):543-7 [1859916] Alcohol Clin Exp Res. 1992 Feb;16(1):30-7 [1373046] Acta Neuropathol. 1993;85(2):117-21 [8442403] Brain Res Brain Res Rev. 1993 Sep-Dec;18(3):247-91 [8401595] J Neuropsychiatry Clin Neurosci. 1994 Fall;6(4):358-70 [7841807] Alcohol Clin Exp Res. 1995 Oct;19(5):1177-91 [8561288] Magn Reson Med. 1996 Dec;36(6):893-906 [8946355] Neuroscience. 1997 Aug;79(4):983-98 [9219961] Am J Addict. 1998 Summer;7(3):221-30 [9702290] Radiology. 1998 Oct;209(1):57-66 [9769812] Brain Res Mol Brain Res. 1998 Nov 20;62(2):196-205 [9813323] Mol Cell Neurosci. 1998 Nov;12(4-5):220-7 [9828087] Magn Reson Med. 1999 Sep;42(3):515-25 [10467296] Neuroreport. 1999 Sep 9;10(13):2817-21 [10511446] Addiction. 2004 Dec;99(12):1491-502 [15585037] Alcohol Clin Exp Res. 2004 Dec;28(12):1849-60 [15608601] Neuropsychopharmacology. 2005 Feb;30(2):423-32 [15562292] Am J Med Genet B Neuropsychiatr Genet. 2005 Jan 5;132B(1):29-37 [15457501] Behav Cogn Neurosci Rev. 2005 Mar;4(1):3-20 [15886400] Am J Psychiatry. 2005 Aug;162(8):1403-13 [16055761] Alcohol Clin Exp Res. 2005 Aug;29(8):1484-95 [16131857] Drug Alcohol Depend. 2005 Oct 1;80(1):105-16 [16157233] Psychopharmacology (Berl). 2005 Aug;180(4):583-94 [15834536] J Int Neuropsychol Soc. 2005 Oct;11(6):727-36 [16248908] J Neurosci Res. 2006 Feb 15;83(3):392-402 [16397901] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.pscychresns.2008.07.012 ER - TY - JOUR T1 - Treatment of a patient with traumatic brain injury-related severe self-injurious behavior. AN - 742781497; pmid-19625868 AB - OBJECTIVE: Report a case of severe self-injurious behavior (SIB), paying special attention to treatment. DESIGN: Case report. PARTICIPANT: A 26-year-old woman (H.S.) 8 years post-traumatic brain injury with a history of severe SIB. METHODS: H.S. was treated over a 22-week period with combined behavioral and psychopharmacological interventions. RESULTS: Marked reduction in SIB was noted after the interventions were initiated. CONCLUSION: Behavioral treatment and medications may be useful tools in the treatment of SIB after traumatic brain injury. JF - The Journal of head trauma rehabilitation AU - Freeman, Thomas AU - High, Walter M AD - Mental Health Service, Central Arkansas Veterans Healthcare System, Little Rock, USA. THOMAS.FREEMAN@MED.VA.GOV Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 292 EP - 296 VL - 24 IS - 4 SN - 0885-9701, 0885-9701 KW - Index Medicus KW - National Library of Medicine KW - Self-Injurious Behavior -- psychology KW - Depression -- therapy KW - Ammonia KW - Humans KW - Depression -- psychology KW - Adult KW - Self-Injurious Behavior -- therapy KW - Female KW - Behavior Therapy KW - Antipsychotic Agents -- therapeutic use KW - Brain Injuries -- psychology KW - Fluphenazine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742781497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+head+trauma+rehabilitation&rft.atitle=Treatment+of+a+patient+with+traumatic+brain+injury-related+severe+self-injurious+behavior.&rft.au=Freeman%2C+Thomas%3BHigh%2C+Walter+M&rft.aulast=Freeman&rft.aufirst=Thomas&rft.date=2009-07-01&rft.volume=24&rft.issue=4&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+head+trauma+rehabilitation&rft.issn=08859701&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Medial or medio-lateral graft tympanoplasty for repair of tympanic membrane perforation. AN - 742781262; pmid-19403180 AB - OBJECTIVE: To describe and evaluate the medio-lateral graft tympanoplasty(1) for the reconstruction of anterior or subtotal tympanic membrane (TM) perforation and medial graft tympanoplasty for posterior TM perforation. METHODS: Retrospective study of 200 patients who underwent medio-lateral graft tympanoplasty (100 cases) and medial graft tympanoplasty (100 cases) at community and tertiary care medical centers from 1995 to 2006. All patients underwent preoperative and postoperative audiograms. In the medial graft tympanoplasty, the graft is placed entirely medial to the remaining TM and malleus. First, margin of TM perforation is denuded removing ring of squamous tissue. Tympanomeatal flap is elevated. Temporalis fascia is harvested, semidried, and grafted medial to the TM perforation and malleus with Gelfoam packing supporting the graft. In the medio-lateral graft technique, posterior tympanomeatal flap is elevated same as in the medial graft tympanoplasty first. Anterior-medial canal skin is elevated down to the annulus. At the annulus only squamous epithelial layer of TM is elevated up to anterior half of the TM perforation. Temporalis fascia is grafted medial to posterior half of the perforation and lateral to anterior half of the de-epithelialized TM perforation up to the annulus. Anterior canal skin is rotated to cover the fascia graft and TM perforation as a second layer closure. Patients were followed for at least six months. Outcome was considered successful if TM is healed and intact. RESULTS: There were four failures (96% success rate) in medial graft method for posterior TM perforation due to infection and re-perforation. In the medio-lateral graft tympanoplasty, there were three failures (97% success rate) due to a postoperative infection, anterior blunting and recurrent cholesteatoma. CONCLUSION: The medial graft tympanoplasty works well for posterior TM perforation. The medio-lateral graft method is an excellent method for the reconstruction of large anterior or subtotal TM perforation. This new method should help otologic surgeons to improve outcome of tympanoplasty for anterior or subtotal TM perforation. JF - International journal of pediatric otorhinolaryngology AU - Jung, Timothy AU - Kim, You Hyun AU - Kim, Yoon Hwan AU - Park, Seong Kook AU - Martin, Dusan AD - Division of Otolaryngology-Head and Neck Surgery, Loma Linda University, Loma Linda, CA, USA. timothy.jung@va.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 941 EP - 943 VL - 73 IS - 7 SN - 0165-5876, 0165-5876 KW - Index Medicus KW - National Library of Medicine KW - Young Adult KW - Tympanic Membrane Perforation -- pathology KW - Tympanoplasty -- adverse effects KW - Humans KW - Retrospective Studies KW - Aged KW - Child KW - Tympanic Membrane Perforation -- surgery KW - Child, Preschool KW - Hearing Loss -- diagnosis KW - Tympanoplasty -- methods KW - Tympanic Membrane -- pathology KW - Aged, 80 and over KW - Adult KW - Treatment Outcome KW - Tympanic Membrane Perforation -- complications KW - Middle Aged KW - Adolescent KW - Hearing Loss -- etiology KW - Tympanic Membrane -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742781262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+pediatric+otorhinolaryngology&rft.atitle=Medial+or+medio-lateral+graft+tympanoplasty+for+repair+of+tympanic+membrane+perforation.&rft.au=Jung%2C+Timothy%3BKim%2C+You+Hyun%3BKim%2C+Yoon+Hwan%3BPark%2C+Seong+Kook%3BMartin%2C+Dusan&rft.aulast=Jung&rft.aufirst=Timothy&rft.date=2009-07-01&rft.volume=73&rft.issue=7&rft.spage=941&rft.isbn=&rft.btitle=&rft.title=International+journal+of+pediatric+otorhinolaryngology&rft.issn=01655876&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Percutaneous coronary intervention complications and guide catheter size: bigger is not better. AN - 67522390; 19628187 AB - We evaluated the association between guiding catheter size and complications of percutaneous coronary intervention (PCI). The association between guiding catheter size and complications of PCI in contemporary practice remains controversial. Procedure and outcome variables from 103,070 consecutive patients that underwent PCI with 6-F (n = 64,335), 7-F (n = 32,676), and 8-F (n = 6,059) guide catheters were compared. Compared with 6-F guides, PCIs performed with 7- and 8-F guides were associated with incrementally more contrast agent use, and more post-PCI complications including contrast-induced nephropathy, vascular access site complications, bleeding, transfusion, major adverse cardiac event, and death. After multivariate analysis, the use of larger guides were associated with a higher risk of contrast-induced nephropathy (7-F odds ratio [OR]: 1.18, p = 0.0004; 8-F OR: 1.44, p 3 g/dl (7-F OR: 1.12, p < 0.0001, 8-F OR: 1.72, p < 0.0001), and post-procedure blood transfusion (7-F OR: 1.08, p = 0.03; 8-F OR: 1.80, p < 0.0001), whereas major adverse cardiac events (7-F OR: 1.06, p = 0.13; 8-F OR: 1.37, p < 0.0001) and in-hospital mortality (7-F OR: 1.11, p = 0.13; 8-F OR: 1.34, p = 0.03) were increased with 8-F but not 7-F guides. Compared with 6-F guides, PCIs performed with 7- and 8-F guides were associated with more contrast medium use, renal complications, bleeding, vascular access site complications, greater need for post-procedure transfusion, and 8-F guides with increased nephropathy requiring dialysis, in-hospital major adverse cardiac events, and mortality. These data suggest that selection of smaller guide catheters may result in improved clinical outcome in patients undergoing contemporary PCI. JF - JACC. Cardiovascular interventions AU - Grossman, P Michael AU - Gurm, Hitinder S AU - McNamara, Richard AU - Lalonde, Thomas AU - Changezi, Hameem AU - Share, David AU - Smith, Dean E AU - Chetcuti, Stanley J AU - Moscucci, Mauro AU - Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2) AD - Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Hospitals and Health System and Veterans Administration Ann Arbor Health System, Ann Arbor, MI 48109-5869, USA. pagross@umich.edu ; Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2) Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 636 EP - 644 VL - 2 IS - 7 KW - Contrast Media KW - 0 KW - Index Medicus KW - United States KW - Odds Ratio KW - Humans KW - Aged KW - Kidney Diseases -- therapy KW - Hemorrhage -- therapy KW - Renal Dialysis KW - Risk Assessment KW - Hemorrhage -- etiology KW - Registries KW - Contrast Media -- adverse effects KW - Equipment Design KW - Risk Factors KW - Hospital Mortality KW - Treatment Outcome KW - Blood Transfusion KW - Middle Aged KW - Heart Diseases -- etiology KW - Male KW - Female KW - Kidney Diseases -- chemically induced KW - Angioplasty, Balloon, Coronary -- mortality KW - Angioplasty, Balloon, Coronary -- adverse effects KW - Angioplasty, Balloon, Coronary -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67522390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JACC.+Cardiovascular+interventions&rft.atitle=Percutaneous+coronary+intervention+complications+and+guide+catheter+size%3A+bigger+is+not+better.&rft.au=Grossman%2C+P+Michael%3BGurm%2C+Hitinder+S%3BMcNamara%2C+Richard%3BLalonde%2C+Thomas%3BChangezi%2C+Hameem%3BShare%2C+David%3BSmith%2C+Dean+E%3BChetcuti%2C+Stanley+J%3BMoscucci%2C+Mauro%3BBlue+Cross+Blue+Shield+of+Michigan+Cardiovascular+Consortium+%28BMC2%29&rft.aulast=Grossman&rft.aufirst=P&rft.date=2009-07-01&rft.volume=2&rft.issue=7&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=JACC.+Cardiovascular+interventions&rft.issn=1876-7605&rft_id=info:doi/10.1016%2Fj.jcin.2009.05.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-02 N1 - Date created - 2009-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jcin.2009.05.012 ER - TY - JOUR T1 - Longitudinal analysis of abstinence-specific social support and smoking cessation. AN - 67484833; 19594271 AB - (1) To replicate previous research finding that abstinence-specific social support during the active phase of quitting predicts short- and long-term smoking cessation treatment outcome. (2) To describe time-related changes in abstinence-specific support, including how support provided during middle and later phases of the quitting process is associated with treatment outcome. Combined data from three randomized clinical trials of smoking cessation treatment (N = 739) were analyzed using logistic regression and analysis of variance. Measures included the Partner Interaction Questionnaire (PIQ; Cohen & Lichtenstein, 1990), a measure of smoking-related social support, and smoking status according to 7-day point-prevalence abstinence. Longitudinal analyses found that positive support peaked at week 12, decreasing thereafter. Positive support provided after week 12 did not differentiate between those who never quit smoking, those who quit and relapsed, and those who maintained abstinence. In contrast, negative support was monotonic and was useful at follow-up points for distinguishing between outcome groups. These results suggest that positive and negative support are both important factors in the early phase of quitting, but it is the continued minimization of negative support that best predicts maintenance of nonsmoking. JF - Health psychology : official journal of the Division of Health Psychology, American Psychological Association AU - Lawhon, Dawn AU - Humfleet, Gary L AU - Hall, Sharon M AU - Muñoz, Ricardo F AU - Reus, Victor I AD - Department of Psychiatry, University of California, San Francisco, CA, USA. dawn.lawhon@va.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 465 EP - 472 VL - 28 IS - 4 SN - 0278-6133, 0278-6133 KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Motivation KW - Tobacco Use Disorder -- rehabilitation KW - Humans KW - Reinforcement (Psychology) KW - Adult KW - Treatment Outcome KW - Tobacco Use Disorder -- psychology KW - Middle Aged KW - Longitudinal Studies KW - Secondary Prevention KW - Male KW - Female KW - Smoking Cessation -- psychology KW - Social Support UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67484833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+psychology+%3A+official+journal+of+the+Division+of+Health+Psychology%2C+American+Psychological+Association&rft.atitle=Longitudinal+analysis+of+abstinence-specific+social+support+and+smoking+cessation.&rft.au=Lawhon%2C+Dawn%3BHumfleet%2C+Gary+L%3BHall%2C+Sharon+M%3BMu%C3%B1oz%2C+Ricardo+F%3BReus%2C+Victor+I&rft.aulast=Lawhon&rft.aufirst=Dawn&rft.date=2009-07-01&rft.volume=28&rft.issue=4&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Health+psychology+%3A+official+journal+of+the+Division+of+Health+Psychology%2C+American+Psychological+Association&rft.issn=02786133&rft_id=info:doi/10.1037%2Fa0015206 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-25 N1 - Date created - 2009-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1037/a0015206 ER - TY - JOUR T1 - Characteristics of hepatitis C virus coinfection in a human immunodeficiency virus-infected population with lower reported rates of injection drug use. AN - 67470442; 19474656 AB - Injection drug use (IDU) is considered the major risk factor for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection. We examined risk factors for HIV/HCV coinfection in a region with a low reported rate of IDU. We identified 146 HIV/HCV coinfected patients in Jackson, Mississippi. Medical records were reviewed for demographics, social history, and risk factors for HIV and HCV acquisition. A randomly selected group of HIV-monoinfected patients from the same clinic served as a control group. History of IDU (P < 0.0001), crack cocaine use (P < 0.0001), incarceration (P < 0.0001), and syphilis (P < 0.0001) were significantly associated with HCV infection in this cohort of HIV patients. However, the reported rate of IDU (32.5%) is lower than other published HIV/HCV-infected cohorts. HIV/HCV patients in Mississippi are less likely to report a history of IDU than other coinfected populations, suggesting an alternative means of HCV transmission. Further studies are needed to examine the role of syphilis, crack cocaine use, and incarceration as risk factors for HCV infection in this population of HIV patients. JF - The American journal of the medical sciences AU - Burton, Mary Jane AU - Olivier, Jake AU - Mena, Leandro AD - Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, Mississippi, USA. mary.burton2@va.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 54 EP - 56 VL - 338 IS - 1 SN - 0002-9629, 0002-9629 KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Mississippi -- epidemiology KW - Comorbidity KW - HIV Infections -- physiopathology KW - Hepatitis C -- etiology KW - HIV Infections -- etiology KW - Hepatitis C -- epidemiology KW - Substance Abuse, Intravenous -- complications KW - HIV Infections -- epidemiology KW - Hepatitis C -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67470442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Characteristics+of+hepatitis+C+virus+coinfection+in+a+human+immunodeficiency+virus-infected+population+with+lower+reported+rates+of+injection+drug+use.&rft.au=Burton%2C+Mary+Jane%3BOlivier%2C+Jake%3BMena%2C+Leandro&rft.aulast=Burton&rft.aufirst=Mary&rft.date=2009-07-01&rft.volume=338&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/10.1097%2FMAJ.0b013e31819e2ad8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-17 N1 - Date created - 2009-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MAJ.0b013e31819e2ad8 ER - TY - JOUR T1 - VA intensive mental health case management in urban and rural areas: veteran characteristics and service delivery. AN - 67439272; 19564221 AB - The availability of mental health services in rural areas--particularly intensive services such as assertive community treatment (ACT)--has been of increasing concern and was the focus of this study. In recent decades the U.S. Department of Veterans Affairs (VA) has developed a national network of ACT-like programs called mental health intensive case management (MHICM), which have served veterans from diverse locations across the country, including urban and rural areas. This study used rural-urban commuting area codes and national VA administrative data to compare characteristics of veterans and patterns of MHICM service delivery among veterans with mental illness living in large urban, large rural, small rural, and isolated rural communities. Among veterans enrolled in MHICM from FY 2000 to FY 2005 (N=5,221), 84% (N=4,373) resided in urban areas, 8% (N=421) in large cities, 6% (N=291) in small rural towns, and 3% (N=136) in isolated rural areas. MHICM participants who lived in rural areas had clinical problems broadly similar to those in urban areas, although more rural veterans were unemployed, disabled, received VA disability compensation, and had a payee or fiduciary. MHICM clients in smaller or isolated rural areas received slightly less frequent and less intensive contacts and less recovery-oriented services than those in large urban locations. These data highlight the need for intensive case management services in rural areas and note some challenges in providing them at the intensity and frequency observed in urban areas where travel distances and times are shorter. JF - Psychiatric services (Washington, D.C.) AU - Mohamed, Somaia AU - Neale, Michael AU - Rosenheck, Robert A AD - Veterans Integrated Services Network 1, Mental Illness Research, Education and Clinical Center, U.S. Department of Veterans Affairs, 950 Campbell Ave., West Haven, CT 06516, USA. somaia.mohamed@yale.edu Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 914 EP - 921 VL - 60 IS - 7 KW - Index Medicus KW - United States KW - Healthcare Disparities -- statistics & numerical data KW - Humans KW - Activities of Daily Living -- psychology KW - Comorbidity KW - Health Services Accessibility -- statistics & numerical data KW - Socioeconomic Factors KW - Cross-Sectional Studies KW - Adult KW - Disability Evaluation KW - Middle Aged KW - Female KW - Male KW - Alcoholism -- rehabilitation KW - Mental Disorders -- rehabilitation KW - Community Mental Health Services -- supply & distribution KW - Rural Population KW - Mental Disorders -- epidemiology KW - Veterans -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Veterans -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Delivery of Health Care KW - Case Management KW - Urban Population KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67439272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=VA+intensive+mental+health+case+management+in+urban+and+rural+areas%3A+veteran+characteristics+and+service+delivery.&rft.au=Mohamed%2C+Somaia%3BNeale%2C+Michael%3BRosenheck%2C+Robert+A&rft.aulast=Mohamed&rft.aufirst=Somaia&rft.date=2009-07-01&rft.volume=60&rft.issue=7&rft.spage=914&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=1557-9700&rft_id=info:doi/10.1176%2Fappi.ps.60.7.914 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-23 N1 - Date created - 2009-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1176/appi.ps.60.7.914 ER - TY - JOUR T1 - Antidepressant-induced suicidality: implications for clinical practice. AN - 67435471; 19488000 AB - The risk of suicidal behavior associated with antidepressant treatment is an issue of debate and concern. The US FDA has required that antidepressants carry a black box warning that there may be a risk of suicidal ideations in depressed pediatric patients treated with these medications, and recently extended the warning to include individuals up age 24. However studies of antidepressant-induced suicidality in adults have yielded contradictory findings and conclusions. This article discusses investigations of this poorly understood phenomenon and the clinical implications of research findings and FDA warnings for clinicians treating adults with depression. Although antidepressant-induced suicidality apparently occurs only rarely, close monitoring and follow up care after the initiation of a new antidepressant is indicated. JF - Southern medical journal AU - Reeves, Roy R AU - Ladner, Mark E AD - Departments of Psychiatry and Neurology, Mental Health Service, GV (Sonny) Montgomery VA Medical Center, University of Mississippi School of Medicine, Jackson, MS 39216, USA. roy.reeves@va.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 713 EP - 718 VL - 102 IS - 7 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Serotonin Uptake Inhibitors KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Evidence-Based Medicine KW - Adverse Drug Reaction Reporting Systems KW - Risk Factors KW - Humans KW - Drug Approval KW - Adult KW - Child KW - Adolescent KW - Meta-Analysis as Topic KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Suicide -- psychology KW - Serotonin Uptake Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67435471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Antidepressant-induced+suicidality%3A+implications+for+clinical+practice.&rft.au=Reeves%2C+Roy+R%3BLadner%2C+Mark+E&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2009-07-01&rft.volume=102&rft.issue=7&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=1541-8243&rft_id=info:doi/10.1097%2FSMJ.0b013e3181a918bd LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/SMJ.0b013e3181a918bd ER - TY - JOUR T1 - Cholecystokinin excites interneurons in rat basolateral amygdala. AN - 67433398; 19386755 AB - The amygdala formation is implicated in generation of emotional states such as anxiety and fear. Many substances that modulate neuronal activity in the amygdala alter anxiety. Cholecystokinin (CCK) is an endogenous neuropeptide that induces anxiety states in behavioral studies in both animals and humans. Using a brain slice preparation, we found that application of CCK increases inhibitory synaptic transmission measured in projection neurons of the basolateral amygdala. To determine the source of the increased inhibition we examined the direct effect of CCK on local interneurons in this region. CCK most strongly depolarized fast-spiking interneurons. Burst-firing and regular-firing interneurons were also depolarized, although to a lesser degree. However, another distinct group of interneurons was unaffected by CCK. These effects were mediated by the CCKB receptor subtype. The excitatory effect of CCK appeared to be mediated by both a nonselective cation and a K+ current. JF - Journal of neurophysiology AU - Chung, Leeyup AU - Moore, Scott D AD - Department of Psychiatry, Duke University Medical Center, Research Service, Veterans Administration Medical Center, 508 Fulton Street, Neurology Research Building 16, Room 25, Durham, NC 27705, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 272 EP - 284 VL - 102 IS - 1 SN - 0022-3077, 0022-3077 KW - Boron Compounds KW - 0 KW - CR 2945 KW - Calcium Channel Blockers KW - Cholagogues and Choleretics KW - Imidazoles KW - Potassium Channel Blockers KW - Receptor, Cholecystokinin B KW - Sodium Channel Blockers KW - Cadmium KW - 00BH33GNGH KW - Benzodiazepines KW - 12794-10-4 KW - Tetrodotoxin KW - 4368-28-9 KW - Tetraethylammonium KW - 66-40-0 KW - Cholecystokinin KW - 9011-97-6 KW - 2-aminoethoxydiphenyl borate KW - E4ES684O93 KW - 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole KW - I61V87164A KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Receptor, Cholecystokinin B -- antagonists & inhibitors KW - Analysis of Variance KW - Electric Stimulation -- methods KW - Imidazoles -- pharmacology KW - Tetraethylammonium -- pharmacology KW - Biophysics KW - Rats KW - Calcium -- metabolism KW - Animals, Newborn KW - Cadmium -- pharmacology KW - Rats, Sprague-Dawley KW - Boron Compounds -- pharmacology KW - Patch-Clamp Techniques KW - Calcium Channel Blockers -- pharmacology KW - Sodium Channel Blockers -- pharmacology KW - Potassium Channel Blockers -- pharmacology KW - In Vitro Techniques KW - Tetrodotoxin -- pharmacology KW - Benzodiazepines -- pharmacology KW - Male KW - Cholagogues and Choleretics -- pharmacology KW - Amygdala -- cytology KW - Interneurons -- drug effects KW - Interneurons -- physiology KW - Cholecystokinin -- pharmacology KW - Interneurons -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67433398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurophysiology&rft.atitle=Cholecystokinin+excites+interneurons+in+rat+basolateral+amygdala.&rft.au=Chung%2C+Leeyup%3BMoore%2C+Scott+D&rft.aulast=Chung&rft.aufirst=Leeyup&rft.date=2009-07-01&rft.volume=102&rft.issue=1&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurophysiology&rft.issn=00223077&rft_id=info:doi/10.1152%2Fjn.90769.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-10 N1 - Date created - 2009-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1152/jn.90769.2008 ER - TY - JOUR T1 - Bite-related and septic syndromes caused by cats and dogs. AN - 67420104; 19555903 AB - Bite infections can contain a mix of anaerobes and aerobes from the patient's skin and the animal's oral cavity, including species of Pasteurella, Streptococcus, Fusobacterium, and Capnocytophaga. Domestic cat and dog bite wounds can produce substantial morbidity and often require specialised care techniques and specific antibiotic therapy. Bite wounds can be complicated by sepsis. Disseminated infections, particularly those caused by Capnocytophaga canimorsus and Pasteurella multocida, can lead to septic shock, meningitis, endocarditis, and other severe sequelae. An emerging syndrome in veterinary and human medicine is meticillin-resistant Staphylococcus aureus (MRSA) infections shared between pets and human handlers, particularly community-acquired MRSA disease involving the USA300 clone. Skin, soft-tissue, and surgical infections are the most common. MRSA-associated infections in pets are typically acquired from their owners and can potentially cycle between pets and their human acquaintances. JF - The Lancet. Infectious diseases AU - Oehler, Richard L AU - Velez, Ana P AU - Mizrachi, Michelle AU - Lamarche, Jorge AU - Gompf, Sandra AD - Division of Infectious Disease and International Medicine, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL 33611, USA. richard.oehler@va.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 439 EP - 447 VL - 9 IS - 7 KW - Index Medicus KW - Animals KW - Sepsis -- etiology KW - Humans KW - Bacterial Infections -- microbiology KW - Bacterial Infections -- epidemiology KW - Cats KW - Dogs KW - Bites and Stings -- complications KW - Bacteria -- isolation & purification KW - Bacteria -- classification KW - Bacterial Infections -- complications KW - Bacterial Infections -- drug therapy KW - Bites and Stings -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67420104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Lancet.+Infectious+diseases&rft.atitle=Bite-related+and+septic+syndromes+caused+by+cats+and+dogs.&rft.au=Oehler%2C+Richard+L%3BVelez%2C+Ana+P%3BMizrachi%2C+Michelle%3BLamarche%2C+Jorge%3BGompf%2C+Sandra&rft.aulast=Oehler&rft.aufirst=Richard&rft.date=2009-07-01&rft.volume=9&rft.issue=7&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=The+Lancet.+Infectious+diseases&rft.issn=1474-4457&rft_id=info:doi/10.1016%2FS1473-3099%2809%2970110-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-06-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Lancet Infect Dis. 2009 Sep;9(9):536 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S1473-3099(09)70110-0 ER - TY - JOUR T1 - Changes in vitamin E prescribing for Alzheimer patients. AN - 67408890; 19546657 AB - At the end of 2006, a survey was sent to members of the American Association of Geriatric Psychiatry (AAGP) to assess possible changes in prescribing Vitamin E to patients with Alzheimer disease that followed two published reports in early 2005 suggesting increased mortality and an increased incidence of heart failure with Vitamin E supplements. A three-item questionnaire was mailed to all AAGP members who had prescription privileges to assess changes in prescribing Vitamin E after January, 2005. A total of 572 completed surveys were returned for a response rate of 35%. Nearly 60% of respondents reported a change over the 2 years that followed the 2005 reports. The greatest change was in the group not prescribing Vitamin E, which increased from 6.6% before 2005 to 60.6% afterward. AAGP members significantly reduced prescribing Vitamin E to patients with Alzheimer disease after 2005. The two reports are discussed with an emphasis on their methodological limitations and the potential for additional information on Vitamin E side effects from ongoing research. JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry AU - Dysken, Maurice W AU - Kirk, Laura Nelson AU - Kuskowski, Michael AD - Geriatric Research, Education, and Clinical Center Program, Minneapolis VA Medical Center, Minneapolis, MN 55417, USA. maurice.dysken@med.va.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 621 EP - 624 VL - 17 IS - 7 KW - Vitamin E KW - 1406-18-4 KW - Index Medicus KW - United States KW - Heart Failure -- mortality KW - Survival Rate KW - Humans KW - Cognition Disorders -- drug therapy KW - Heart Failure -- chemically induced KW - Incidence KW - Aged KW - Data Collection KW - Cognition Disorders -- mortality KW - Hospitalization -- trends KW - Alzheimer Disease -- mortality KW - Alzheimer Disease -- drug therapy KW - Vitamin E -- therapeutic use KW - Vitamin E -- adverse effects KW - Guideline Adherence -- trends KW - Geriatric Psychiatry -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67408890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+geriatric+psychiatry+%3A+official+journal+of+the+American+Association+for+Geriatric+Psychiatry&rft.atitle=Changes+in+vitamin+E+prescribing+for+Alzheimer+patients.&rft.au=Dysken%2C+Maurice+W%3BKirk%2C+Laura+Nelson%3BKuskowski%2C+Michael&rft.aulast=Dysken&rft.aufirst=Maurice&rft.date=2009-07-01&rft.volume=17&rft.issue=7&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+geriatric+psychiatry+%3A+official+journal+of+the+American+Association+for+Geriatric+Psychiatry&rft.issn=1545-7214&rft_id=info:doi/10.1097%2FJGP.0b013e3181a31fcf LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-23 N1 - Date created - 2009-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/JGP.0b013e3181a31fcf ER - TY - JOUR T1 - Risk of lipid abnormality with haloperidol, olanzapine, quetiapine, and risperidone in a Veterans Affairs population. AN - 67400671; 19494785 AB - Second-generation antipsychotics can cause lipid elevations at a greater rate than older typical antipsychotics. This risk may not be equivalent amongst the second-generation antipsychotics. We conducted a computerized, retrospective, nonrandomized, case-control analysis of 6331 patients receiving antipsychotics. For each patient, the first prescription for at least 60 continuous days for four antipsychotics [haloperidol (HALD), olanzapine (OLANZ), quetiapine (QUET), or risperidone (RISP)] was analyzed for total cholesterol, low-density lipoprotein, high-density lipoprotein (HDL), and triglycerides (TGL). Mean HDL was lower during OLANZ treatment than with RISP (P = 0.03) or QUET (P = 0.001). TGL were higher during OLANZ (P = 0.0007) or QUET treatment (P = 0.006) than RISP. In dichotomous analyses, odds ratios on the percentage of participants having abnormal cholesterol (P = 0.0003), low-density lipoprotein (P = 0.001), or TGL (P = 0.0001) during medication were in the order: OLANZ > QUET > RISP > HALD. For HDL, the results were less robust but the percentage of participants were in the order: OLANZ>RISP = HALD = QUET. In treatment-emergent analyses of patients without lipid abnormalities during an unmedicated baseline period, there was a greater risk of developing new HDL abnormality with OLANZ than RISP (P<0.05). In conclusion, treatment with RISP or HALD was associated with a more favorable lipid profile than with OLANZ or QUET. JF - International clinical psychopharmacology AU - Duncan, Erica J AU - Woolson, Sandra L AU - Hamer, Robert M AU - Dunlop, Boadie W AD - Mental Health Service, Atlanta VA Medical Center, GA 30033, USA. erica.duncan@va.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 204 EP - 213 VL - 24 IS - 4 KW - Antipsychotic Agents KW - 0 KW - Dibenzothiazepines KW - Benzodiazepines KW - 12794-10-4 KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Haloperidol KW - J6292F8L3D KW - Risperidone KW - L6UH7ZF8HC KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - United States KW - United States Department of Veterans Affairs KW - Humans KW - Retrospective Studies KW - Case-Control Studies KW - Risk Assessment -- statistics & numerical data KW - Time Factors KW - Male KW - Female KW - Haloperidol -- adverse effects KW - Antipsychotic Agents -- administration & dosage KW - Dibenzothiazepines -- adverse effects KW - Benzodiazepines -- adverse effects KW - Hypertriglyceridemia -- chemically induced KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Dyslipidemias -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67400671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+clinical+psychopharmacology&rft.atitle=Risk+of+lipid+abnormality+with+haloperidol%2C+olanzapine%2C+quetiapine%2C+and+risperidone+in+a+Veterans+Affairs+population.&rft.au=Duncan%2C+Erica+J%3BWoolson%2C+Sandra+L%3BHamer%2C+Robert+M%3BDunlop%2C+Boadie+W&rft.aulast=Duncan&rft.aufirst=Erica&rft.date=2009-07-01&rft.volume=24&rft.issue=4&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=International+clinical+psychopharmacology&rft.issn=1473-5857&rft_id=info:doi/10.1097%2FYIC.0b013e32832d6c18 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-15 N1 - Date created - 2009-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/YIC.0b013e32832d6c18 ER - TY - JOUR T1 - Access to primary care for homeless veterans with serious mental illness or substance abuse: a follow-up evaluation of co-located primary care and homeless social services. AN - 67352795; 19280333 AB - To examine the hypothesis that a demonstration clinic integrating homeless, primary care, and mental health services for homeless veterans with serious mental illness or substance abuse would improve medical health care access and physical health status. A quasi-experimental design comparing a 'usual VA care' group before the demonstration clinic opened (N = 130) and the 'integrated care' group (N = 130). Regression models indicated that the integrated care group was more rapidly enrolled in primary care, received more prevention services and primary care visits, and fewer emergency department visits, and was not different in inpatient utilization or in physical health status over 18 months. The demonstration clinic improved access to primary care services and reduced emergency services but did not improve perceived physical health status over 18 months. Further research is needed to determine generalizability and longer term effects. JF - Administration and policy in mental health AU - McGuire, James AU - Gelberg, Lillian AU - Blue-Howells, Jessica AU - Rosenheck, Robert A AD - Department of Veterans Affairs Northeast Program Evaluation Center (NEPEC), Los Angeles, CA, USA. James.McGuire@va.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 255 EP - 264 VL - 36 IS - 4 KW - Index Medicus KW - Humans KW - Adult KW - Interviews as Topic KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Severity of Illness Index KW - Social Work, Psychiatric KW - Mental Disorders KW - Veterans -- psychology KW - Substance-Related Disorders KW - Primary Health Care KW - Homeless Persons KW - Health Services Accessibility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67352795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+policy+in+mental+health&rft.atitle=Access+to+primary+care+for+homeless+veterans+with+serious+mental+illness+or+substance+abuse%3A+a+follow-up+evaluation+of+co-located+primary+care+and+homeless+social+services.&rft.au=McGuire%2C+James%3BGelberg%2C+Lillian%3BBlue-Howells%2C+Jessica%3BRosenheck%2C+Robert+A&rft.aulast=McGuire&rft.aufirst=James&rft.date=2009-07-01&rft.volume=36&rft.issue=4&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Administration+and+policy+in+mental+health&rft.issn=1573-3289&rft_id=info:doi/10.1007%2Fs10488-009-0210-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-08 N1 - Date created - 2009-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10488-009-0210-6 ER - TY - JOUR T1 - Psychiatric and substance use disorders comorbidities in veterans with hepatitis C virus and HIV coinfection. AN - 67315979; 19436202 AB - A growing number of veterans in the Veterans Health Administration are coinfected with HIV and hepatitis C virus. This review covers timely research relative to comorbid conditions that are common in this population including psychiatric diagnoses, substance use disorders and neurocognitive problems. Current literature on the psychiatric, substance use disorders and cognitive problems of the coinfected population show that not only are rates of morbidity higher in the coinfected population but that this affects antiviral treatments as well. There is new evidence that brain injuries and infiltration of the virus into the central nervous system may be responsible for cognitive dysfunction. Cotesting, particularly in hepatitis C infected individuals, is not done routinely despite shared risk factors. With this understanding of the comorbidities of the coinfected population, integrated healthcare models involving mental health, internal medicine, substance abuse treatment and internal medicine are crucial to work with these medically and psychologically complex patients. JF - Current opinion in psychiatry AU - Fuller, Bret E AU - Loftis, Jennifer M AU - Rodriguez, Veronica L AU - McQuesten, Matthew J AU - Hauser, Peter AD - Mental Health Division, Portland Veterans Affairs Medical Center, Portland, Oregon 97210, USA. bret.fuller@va.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 401 EP - 408 VL - 22 IS - 4 KW - Antiviral Agents KW - 0 KW - Index Medicus KW - Cross-Sectional Studies KW - Antiviral Agents -- administration & dosage KW - Patient Care Team KW - Cognition Disorders -- epidemiology KW - Humans KW - Cognition Disorders -- rehabilitation KW - Interdisciplinary Communication KW - Neuropsychological Tests KW - Medication Adherence -- psychology KW - Comorbidity KW - Cognition Disorders -- psychology KW - HIV Seropositivity -- rehabilitation KW - HIV Seropositivity -- psychology KW - Veterans -- statistics & numerical data KW - Hepatitis C, Chronic -- rehabilitation KW - Hepatitis C, Chronic -- psychology KW - Hepatitis C, Chronic -- epidemiology KW - Veterans -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - HIV Seropositivity -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67315979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+psychiatry&rft.atitle=Psychiatric+and+substance+use+disorders+comorbidities+in+veterans+with+hepatitis+C+virus+and+HIV+coinfection.&rft.au=Fuller%2C+Bret+E%3BLoftis%2C+Jennifer+M%3BRodriguez%2C+Veronica+L%3BMcQuesten%2C+Matthew+J%3BHauser%2C+Peter&rft.aulast=Fuller&rft.aufirst=Bret&rft.date=2009-07-01&rft.volume=22&rft.issue=4&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+psychiatry&rft.issn=1473-6578&rft_id=info:doi/10.1097%2FYCO.0b013e32832cadb9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-28 N1 - Date created - 2009-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/YCO.0b013e32832cadb9 ER - TY - JOUR T1 - Sexual Desire and Depression Following Spinal Cord Injury: Masculine Sexual Prowess as a Moderator AN - 61784831; 200940681 AB - Men's adherence to masculine norms stressing sexual prowess may contribute to their adjustment to changes in sexual functioning following spinal cord injury. The authors test this hypothesis by examining the moderating role of men's conformity to gender norms for sexual prowess on the relationship between sexual desire and depression. One hundred and sixteen male citizens of the United States with spinal cord injuries were recruited for participation in the internet-based survey. Results indicated that participants with strong sexual desire evinced higher rates of depression when they conformed to masculine norms emphasizing sexual prowess. Men with little reported sexual desire, by contrast, demonstrated lower rates of depression when they endorsed norms for prowess. Directions for future research and treatment interventions are offered. Adapted from the source document. JF - Sex Roles: A Journal of Research AU - Burns, Shaun Michael AU - Hough, Sigmund AU - Boyd, Briana L AU - Hill, Justin AD - VA Boston Healthcare System, Harvard University Medical School, Boston University School of Medicine, Boston, MA, USA shaun.burns@va.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 120 EP - 129 PB - Springer Science+Business Media, Inc., New York NY VL - 61 IS - 1-2 SN - 0360-0025, 0360-0025 KW - Masculinity KW - Desire KW - Depression (Psychology) KW - Sex Role Identity KW - Males KW - Conformity KW - article KW - 1940: the family and socialization; sociology of sexual behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61784831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sex+Roles%3A+A+Journal+of+Research&rft.atitle=Sexual+Desire+and+Depression+Following+Spinal+Cord+Injury%3A+Masculine+Sexual+Prowess+as+a+Moderator&rft.au=Burns%2C+Shaun+Michael%3BHough%2C+Sigmund%3BBoyd%2C+Briana+L%3BHill%2C+Justin&rft.aulast=Burns&rft.aufirst=Shaun&rft.date=2009-07-01&rft.volume=61&rft.issue=1-2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Sex+Roles%3A+A+Journal+of+Research&rft.issn=03600025&rft_id=info:doi/10.1007%2Fs11199-009-9615-7 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 55 N1 - Last updated - 2016-09-28 N1 - CODEN - SROLDH N1 - SubjectsTermNotLitGenreText - Males; Depression (Psychology); Sex Role Identity; Masculinity; Conformity; Desire DO - http://dx.doi.org/10.1007/s11199-009-9615-7 ER - TY - JOUR T1 - Eldercare in a Filipino Community: Older Women's Attitudes toward Caregiving and Service Use AN - 61749990; 200941285 AB - Focus group research on elderly Filipino women living in the United States yields preliminary findings regarding their attitudes toward caregiving and formal service use. Filipino cultural values and the economic challenges attributed to their immigration status were perceived to be the greatest strengths and challenges in caring for the aged. Results identify generally positive attitudes toward formal service use and governmental assistance. Together, these findings shed light on Filipinos' acceptance and use of formal services. Further research to confirm and explore these findings can guide the design of the nation's practice and policy interventions for an increasingly ethnic and cultural diverse older population. Adapted from the source document. JF - Journal of Women & Aging AU - Kimura, Jennifer AU - Browne, Colette V AD - Spark Matsunaga Outpatient Clinic, Veterans Administration, Honolulu, HI Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 229 EP - 243 PB - Taylor & Francis, Philadelphia PA VL - 21 IS - 3 SN - 0895-2841, 0895-2841 KW - Caregivers KW - Attitudes KW - Communities KW - Services KW - Elderly KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61749990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Women+%26+Aging&rft.atitle=Eldercare+in+a+Filipino+Community%3A+Older+Women%27s+Attitudes+toward+Caregiving+and+Service+Use&rft.au=Kimura%2C+Jennifer%3BBrowne%2C+Colette+V&rft.aulast=Kimura&rft.aufirst=Jennifer&rft.date=2009-07-01&rft.volume=21&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Journal+of+Women+%26+Aging&rft.issn=08952841&rft_id=info:doi/10.1080%2F08952840903054815 LA - English DB - Sociological Abstracts N1 - Date revised - 2009-10-02 N1 - Number of references - 33 N1 - Last updated - 2016-09-28 N1 - CODEN - JWAGE5 N1 - SubjectsTermNotLitGenreText - Elderly; Communities; Attitudes; Caregivers; Services DO - http://dx.doi.org/10.1080/08952840903054815 ER - TY - JOUR T1 - Concerns about Aspects of Harm Reduction and the Overselling of Evidence-Based Practices in the Treatment of Alcohol/Other Drug Problems AN - 61423134; 200907434 AB - This opinion piece addresses concerns about the negative impressions offered by some harm reduction advocates about historical alcohol and other drug (AOD) treatment and abstinence-based programs, as well as advocates who would insist that only evidence-based practices be used in AOD treatment. Adapted from the source document. JF - Alcoholism Treatment Quarterly AU - Carroll, Jerome F X AD - NYHHCS Brooklyn VA Hospital, Psychology Dept., 800 Poly Place, Brooklyn, NY 11209 jerome.carroll@med.va.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 329 EP - 337 PB - Haworth/Taylor & Francis Group, Philadephia, PA VL - 27 IS - 3 SN - 0734-7324, 0734-7324 KW - Harm reduction, evidence-based practice, AOD treatment, professional concerns KW - Harm Reduction KW - Alcohol Abuse KW - Treatment Programs KW - Evidence Based Practice KW - Drug Abuse KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61423134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism+Treatment+Quarterly&rft.atitle=Concerns+about+Aspects+of+Harm+Reduction+and+the+Overselling+of+Evidence-Based+Practices+in+the+Treatment+of+Alcohol%2FOther+Drug+Problems&rft.au=Carroll%2C+Jerome+F+X&rft.aulast=Carroll&rft.aufirst=Jerome+F&rft.date=2009-07-01&rft.volume=27&rft.issue=3&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Alcoholism+Treatment+Quarterly&rft.issn=07347324&rft_id=info:doi/10.1080%2F07347320903014271 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 13 N1 - Last updated - 2016-09-28 N1 - CODEN - ATQUE7 N1 - SubjectsTermNotLitGenreText - Drug Abuse; Harm Reduction; Evidence Based Practice; Treatment Programs; Alcohol Abuse DO - http://dx.doi.org/10.1080/07347320903014271 ER - TY - JOUR T1 - Psychotherapies for Trauma and Substance Abuse in Women: Review and Policy Implications AN - 61391179; 200906197 AB - Women are subject to high rates of interpersonal violence. One frequent co-occurring issue is substance abuse, which may arise posttrauma as a way to cope. In this article, psychosocial therapies for co-occurring trauma and substance abuse are reviewed. Description of empirically studied models is provided, as well as results of the empirical studies. Overall, this area of work suggests positive growth in the availability of new models but very limited empirical work thus far for all but one model. Directions for the future include the need for greater study of treatments in this area, as well as the need to address issues beyond specific models (e.g., workforce issues, access to care, and changing the culture of treatment systems). Policy implications are also offered. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Trauma, Violence, & Abuse: A Review Journal AU - Najavits, Lisa M AD - VA Boston; 150 South Huntington Avenue (116B-3); Boston, MA 02130 lisa.najavits@va.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 290 EP - 298 PB - Sage Publications, Thousand Oaks CA VL - 10 IS - 3 SN - 1524-8380, 1524-8380 KW - trauma, substance abuse, co-occurring disorders, treatment, psychotherapy, posttraumatic stress disorder, substance use disorder, chemical dependency, alcoholism KW - Substance Abuse KW - Females KW - Violence KW - Treatment KW - Trauma KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61391179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trauma%2C+Violence%2C+%26+Abuse%3A+A+Review+Journal&rft.atitle=Psychotherapies+for+Trauma+and+Substance+Abuse+in+Women%3A+Review+and+Policy+Implications&rft.au=Najavits%2C+Lisa+M&rft.aulast=Najavits&rft.aufirst=Lisa&rft.date=2009-07-01&rft.volume=10&rft.issue=3&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Trauma%2C+Violence%2C+%26+Abuse%3A+A+Review+Journal&rft.issn=15248380&rft_id=info:doi/10.1177%2F1524838009334455 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 47 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Treatment; Substance Abuse; Females; Trauma; Violence DO - http://dx.doi.org/10.1177/1524838009334455 ER - TY - JOUR T1 - Preliminary communication: An fMRI motor activation paradigm demonstrates abnormalities of putamen activation in females with panic disorder AN - 57302546; 200915873 AB - Background The neurobiology of panic disorder is incompletely understood. The aim of this study was to determine if functional abnormalities of the putamen occur in panic disorder. Methods Activation patterns of 12 female subjects with panic disorder were compared to 18 female healthy controls using functional MRI at 3 T. A motor activation paradigm was used to probe putamen function. Results A complex motor activation paradigm for the non-dominant hand revealed decreased activation of the bilateral putamen among subjects with panic disorder. Limitations The sample size was a relatively small cohort of non-depressed females. Further, some panic disorder subjects were taking medications and/or had comorbid conditions. However, second-level regression analyses did not reveal any correlations between medication use or comorbidity and activation patterns demonstrated by the non-dominant hand complex task. Finally, we used a post-hoc approach to determine the magnitude of global fMRI signal as a surrogate index of the global cerebral blood flow as a means of controlling for possible confounds from reduction of BOLD signal secondary to cerebral vasoconstriction resulting from possible hyperventilation among panic subjects. A more compelling approach would have been to record the respiratory data from subjects during scanning. Conclusions Our findings suggest that putamen dysfunction occurs in at least some cases of panic disorder. We also provide preliminary evidence that a complex motor task for the non-dominant hand is a useful probe of putamen function in this disorder. [Copyright Elsevier B.V.] JF - Journal of Affective Disorders AU - Marchand, William R AU - Lee, James N AU - Healy, Lindsey AU - Thatcher, John W AU - Rashkin, Esther AU - Starr, Jennifer AU - Hsu, Ed AD - Department of Veterans Affairs VISN 19 MIRECC, Salt Lake City, Utah, USA william.marchand@va.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 121 EP - 125 PB - Elsevier Ltd, The Netherlands VL - 116 IS - 1-2 SN - 0165-0327, 0165-0327 KW - Panic disorder Functional MRI Basal ganglia KW - Panic disorders KW - Signals KW - Surrogates KW - Dysfunction KW - Comorbidity KW - Models KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57302546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Affective+Disorders&rft.atitle=Preliminary+communication%3A+An+fMRI+motor+activation+paradigm+demonstrates+abnormalities+of+putamen+activation+in+females+with+panic+disorder&rft.au=Marchand%2C+William+R%3BLee%2C+James+N%3BHealy%2C+Lindsey%3BThatcher%2C+John+W%3BRashkin%2C+Esther%3BStarr%2C+Jennifer%3BHsu%2C+Ed&rft.aulast=Marchand&rft.aufirst=William&rft.date=2009-07-01&rft.volume=116&rft.issue=1-2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Journal+of+Affective+Disorders&rft.issn=01650327&rft_id=info:doi/10.1016%2Fj.jad.2008.10.026 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Panic disorders; Models; Signals; Comorbidity; Dysfunction; Surrogates DO - http://dx.doi.org/10.1016/j.jad.2008.10.026 ER - TY - JOUR T1 - Effects of Social Support and Conflict on Parenting Among Homeless Mothers AN - 21239314; 11268916 AB - Research has shown that having a supportive social network is generally beneficial for individuals, particularly those who are homeless or at risk of homelessness. However, conflict within these networks may diminish the positive effects of social support on well-being, and these effects may be felt acutely within a vulnerable population with multiple needs. This study examined the impact of conflict and social support on parenting behaviors in a sample of mothers who are homeless and were involved in a study of case management interventions of varying intensity. We found that women who reported high emotional and instrumental social support self-reported greater improvements in parenting consistency over time than those who reported lower levels of support. However, three-way interactions showed that conflict in support networks was a risk factor for harsh parenting practices among participants who reported lower levels of instrumental social support. Results suggest that social support may enhance homeless mothers' ability to provide consistent parenting, but that these benefits may be undermined if conflict occurs in combination with limited levels of instrumental social support. JF - American Journal of Orthopsychiatry AU - Marra, Jaime V AU - McCarthy, Elissa AU - Lin, Hsiu-Ju AU - Ford, Julian AU - Rodis, Eleni AU - Frisman, Linda K AD - James A. Haley Tampa Veterans Administration Medical Center, Tampa, FL, jaime.marra@gmail.com Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 348 EP - 356 PB - American Psychological Association, 750 First St., N.E. Washington DC 20002-4242 USA VL - 79 IS - 3 SN - 0002-9432, 0002-9432 KW - parenting KW - Risk Abstracts KW - conflicts KW - intervention KW - vulnerability KW - Homelessness KW - Family studies KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21239314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Orthopsychiatry&rft.atitle=Effects+of+Social+Support+and+Conflict+on+Parenting+Among+Homeless+Mothers&rft.au=Marra%2C+Jaime+V%3BMcCarthy%2C+Elissa%3BLin%2C+Hsiu-Ju%3BFord%2C+Julian%3BRodis%2C+Eleni%3BFrisman%2C+Linda+K&rft.aulast=Marra&rft.aufirst=Jaime&rft.date=2009-07-01&rft.volume=79&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Orthopsychiatry&rft.issn=00029432&rft_id=info:doi/10.1037%2Fa0017241 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - conflicts; vulnerability; intervention; Family studies; Homelessness DO - http://dx.doi.org/10.1037/a0017241 ER - TY - JOUR T1 - The link between obesity and albuminuria: adiponectin and podocyte dysfunction AN - 20927380; 10986338 AB - With the recent rise in the prevalence of obesity worldwide, obesity-related albuminuria is now being recognized as a critical risk factor for cardiovascular disease. However, there is an urgent need for a better understanding of this association. Recent clinical studies suggest that the adipocyte hormone adiponectin may play a key role in the development of obesity-related albuminuria. Moreover, studies with the adiponectin knockout mouse indicate that adiponectin can regulate podocyte function and thus contribute to the initial development of albuminuria. Future studies examining renal adipocyte cell biology are needed to develop preventive and therapeutic strategies for combatting the complications of obesity.Kidney International (2009) 76, 145-148; doi:10.1038/ki.2009.137; published online 29 April 2009 JF - Kidney International AU - Sharma, Kumar AD - Center for Renal Translational Medicine, University of California, San Diego, La Jolla, CA/Veterans Administration San Diego Health Care System, La Jolla, California, USA Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 145 EP - 148 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 76 IS - 2 SN - 0085-2538, 0085-2538 KW - Physical Education Index KW - Obesity KW - Risk factors KW - Strategy KW - Cardiorespiratory KW - Diseases KW - Kidneys KW - Hormones KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20927380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+International&rft.atitle=The+link+between+obesity+and+albuminuria%3A+adiponectin+and+podocyte+dysfunction&rft.au=Sharma%2C+Kumar&rft.aulast=Sharma&rft.aufirst=Kumar&rft.date=2009-07-01&rft.volume=76&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Kidney+International&rft.issn=00852538&rft_id=info:doi/10.1038%2Fki.2009.137 LA - English DB - Physical Education Index N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Kidneys; Obesity; Cardiorespiratory; Diseases; Hormones; Strategy; Risk factors DO - http://dx.doi.org/10.1038/ki.2009.137 ER - TY - JOUR T1 - DITPA (3,5-Diiodothyropropionic Acid), a thyroid hormone analog to treat heart failure: phase II trial veterans affairs cooperative study. AN - 67410283; 19506112 AB - In animal studies and a pilot trial in patients with congestive heart failure, the thyroid hormone analog 3,5 diiodothyropropionic acid (DITPA) had beneficial hemodynamic effects. This was a phase II multicenter, randomized, placebo-controlled, double-blind trial of New York Heart Association class II to IV congestive heart failure patients randomized (2:1) to DITPA or placebo and treated for 6 months. The study enrolled 86 patients (n=57 to DITPA, n=29 to placebo). The primary objective was to assess the effect of DITPA on a composite congestive heart failure end point that classifies patients as improved, worsened, or unchanged based on symptom changes and morbidity/mortality. DITPA was poorly tolerated, which obscured the interpretation of congestive heart failure-specific effects. Fatigue and gastrointestinal complaints, in particular, were more frequent in the DITPA group. DITPA increased cardiac index (by 18%) and decreased systemic vascular resistance (by 11%), serum cholesterol (-20%), low-density lipoprotein cholesterol (-30%), and body weight (-11 lb). Thyroid-stimulating hormone was suppressed in patients given DITPA, which reflects its thyromimetic effect; however, no symptoms or signs of potential hypothyroidism or thyrotoxicosis were seen. DITPA improved some hemodynamic and metabolic parameters, but there was no evidence for symptomatic benefit in congestive heart failure. JF - Circulation AU - Goldman, Steven AU - McCarren, Madeline AU - Morkin, Eugene AU - Ladenson, Paul W AU - Edson, Robert AU - Warren, Stuart AU - Ohm, Janet AU - Thai, Hoang AU - Churby, Lori AU - Barnhill, Jamie AU - O'Brien, Terrence AU - Anand, Inder AU - Warner, Alberta AU - Hattler, Brack AU - Dunlap, Mark AU - Erikson, John AU - Shih, Mei-Chiung AU - Lavori, Phil AD - Cardiology Section (1-111C), Southern Arizona VA Health Care System, 3601 S 6th Ave, Tucson, AZ 85723, USA. steven.goldman@va.gov Y1 - 2009/06/23/ PY - 2009 DA - 2009 Jun 23 SP - 3093 EP - 3100 VL - 119 IS - 24 KW - Diiodothyronines KW - 0 KW - Lipoproteins, LDL KW - Propionates KW - Thyroid Hormones KW - 3,5-diiodothyropropionic acid KW - 1158-10-7 KW - Cholesterol KW - 97C5T2UQ7J KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Fatigue -- blood KW - Double-Blind Method KW - Humans KW - Fatigue -- chemically induced KW - Aged KW - Gastrointestinal Diseases -- chemically induced KW - Vascular Resistance -- drug effects KW - Lipoproteins, LDL -- blood KW - Body Weight KW - Cholesterol -- blood KW - Gastrointestinal Diseases -- blood KW - United States Department of Veterans Affairs KW - Adult KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Heart Failure -- drug therapy KW - Diiodothyronines -- adverse effects KW - Diiodothyronines -- administration & dosage KW - Propionates -- adverse effects KW - Propionates -- administration & dosage KW - Heart Failure -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67410283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=DITPA+%283%2C5-Diiodothyropropionic+Acid%29%2C+a+thyroid+hormone+analog+to+treat+heart+failure%3A+phase+II+trial+veterans+affairs+cooperative+study.&rft.au=Goldman%2C+Steven%3BMcCarren%2C+Madeline%3BMorkin%2C+Eugene%3BLadenson%2C+Paul+W%3BEdson%2C+Robert%3BWarren%2C+Stuart%3BOhm%2C+Janet%3BThai%2C+Hoang%3BChurby%2C+Lori%3BBarnhill%2C+Jamie%3BO%27Brien%2C+Terrence%3BAnand%2C+Inder%3BWarner%2C+Alberta%3BHattler%2C+Brack%3BDunlap%2C+Mark%3BErikson%2C+John%3BShih%2C+Mei-Chiung%3BLavori%2C+Phil&rft.aulast=Goldman&rft.aufirst=Steven&rft.date=2009-06-23&rft.volume=119&rft.issue=24&rft.spage=3093&rft.isbn=&rft.btitle=&rft.title=Circulation&rft.issn=1524-4539&rft_id=info:doi/10.1161%2FCIRCULATIONAHA.108.834424 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-14 N1 - Date created - 2009-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Circulation. 2010 Mar 16;121(10):e240; author reply e241 [20231540] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1161/CIRCULATIONAHA.108.834424 ER - TY - CPAPER T1 - Immersive Panoramic Video Display Compared to Flat Screen Display: Psychological and Physiological Reactions to Anger Stimuli T2 - 14th Annual International CyberTherapy and CyberPsychology Conference (CT14) AN - 40231385; 5204222 JF - 14th Annual International CyberTherapy and CyberPsychology Conference (CT14) AU - Folen, Raymond AU - Miyahira, S AU - Stetz, M Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 KW - Psychology KW - Video display terminals KW - Physiology KW - Emotions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40231385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+International+CyberTherapy+and+CyberPsychology+Conference+%28CT14%29&rft.atitle=Immersive+Panoramic+Video+Display+Compared+to+Flat+Screen+Display%3A+Psychological+and+Physiological+Reactions+to+Anger+Stimuli&rft.au=Folen%2C+Raymond%3BMiyahira%2C+S%3BStetz%2C+M&rft.aulast=Folen&rft.aufirst=Raymond&rft.date=2009-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+International+CyberTherapy+and+CyberPsychology+Conference+%28CT14%29&rft.issn=&rft_id=info:doi/ L2 - http://frontiersin.org/conferences/individual_conference_listing.php?c onfid=257&ind=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Evaluation of the International Outcome Inventory for Hearing Aids in a veteran sample. AN - 85383536; pmid-19594085 AB - The International Outcome Inventory for Hearing Aids (IOI-HA) was developed as a global hearing aid outcome measure targeting seven outcome domains. The published norms were based on a private-pay sample who were fitted with analog hearing aids.The purpose of this study was to evaluate the psychometric properties of the IOI-HA and to establish normative data in a veteran sample.Survey.The participants were 131 male veterans (mean age of 74.3 years, SD = 7.4) who were issued hearing aids with digital signal processing (DSP).Hearing aids with DSP that were fitted bilaterally between 2005 and 2007.Veterans were mailed two copies of the IOI-HA. The participants were instructed to complete the first copy of the questionnaire immediately and the second copy in two weeks. The completed questionnaires were mailed to the laboratory. The psychometric properties of the questionnaire were evaluated. As suggested by Cox and colleagues, the participants were divided into two categories based on their unaided subjective hearing difficulty. The two categories were (1) those with less hearing difficulty (none-to-moderate category) and (2) those who report more hearing difficulty (moderately severe+ category). The norms from the current veteran sample then were compared to the original, published sample. For each hearing difficulty category, the critical difference values were calculated for each item and for the total score.A factor analysis showed that the IOI-HA in the veteran sample had the identical subscale structure as reported in the original sample. For the total scale, the internal consistency was good (Chronbach's alpha = 0.83), and the test-retest reliability was high (lambda = 0.94). Group and individual norms were developed for both hearing difficulty categories in the veteran sample. For each IOI-HA item, the critical difference scores were < 1.0. This finding suggests that for any item on the IOI-HA, there is a 95 percent chance that an observed change of one response unit between two test sessions reflects a true change in outcome for a given domain.The results of this study confirmed that the psychometric properties of the IOI-HA questionnaire are strong and are essentially the same for the veteran sample and the original private-pay sample. The veteran norms, however, produced higher outcomes than those established originally, possibly because of differences in the population samples and/or hearing aid technology. Clinical and research applications of the current findings are presented. Based on the results from the current study, the norms established here should replace the original norms for use in veterans with current hearing aid technology. JF - Journal of the American Academy of Audiology AU - Smith, Sherri L AU - Noe, Colleen M AU - Alexander, Genevieve C AD - James H. Quillen VA Medical Center, Audiology 126, Mountain Home, TN 37684, USA. sherri.smith@va.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 374 EP - 380 VL - 20 IS - 6 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - Data Collection KW - *Hearing Aids KW - *Hearing Loss: therapy KW - Humans KW - Male KW - Middle Aged KW - *Patient Satisfaction KW - Psychometrics: methods KW - Psychometrics: standards KW - Questionnaires: standards KW - Reproducibility of Results KW - Treatment Outcome KW - *Veterans: psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85383536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Evaluation+of+the+International+Outcome+Inventory+for+Hearing+Aids+in+a+veteran+sample.&rft.au=Smith%2C+Sherri+L%3BNoe%2C+Colleen+M%3BAlexander%2C+Genevieve+C&rft.aulast=Smith&rft.aufirst=Sherri&rft.date=2009-06-01&rft.volume=20&rft.issue=6&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Parkinson disease: systemic and orofacial manifestations, medical and dental management. AN - 67317063; 19491161 AB - More than 1.5 million Americans have Parkinson disease (PD), and this figure is expected to rise as the population ages. However, the dental literature offers little information about the illness. The authors conducted a MEDLINE search using the key terms "Parkinson's disease," "medical management" and "dentistry." They selected contemporaneous articles published in peer-reviewed journals and gave preference to articles reporting randomized controlled trials. PD is a progressive neurodegenerative disorder caused by loss of dopaminergic and nondopaminergic neurons in the brain. These deficits result in tremor, slowness of movement, rigidity, postural instability and autonomic and behavioral dysfunction. Treatment consists of administering medications that replace dopamine, stimulate dopamine receptors and modulate other neurotransmitter systems. Oral health may decline because of tremors, muscle rigidity and cognitive deficits. The dentist should consult with the patient's physician to establish the patient's competence to provide informed consent and to determine the presence of comorbid illnesses. Scheduling short morning appointments that begin 90 minutes after administration of PD medication enhances the patient's ability to cooperate with care. Inclination of the dental chair at 45 degrees, placement of a bite prop, use of a rubber dam and high-volume oral evacuation enhance airway protection. To avoid adverse drug interactions with levodopa and entacapone, the dentist should limit administration of local anesthetic agents to three cartridges of 2 percent lidocaine with 1:100,000 epinephrine per half hour, and patients receiving selegiline should not be given agents containing epinephrine or levonordefrin. The dentist should instruct the patient and the caregiver in good oral hygiene techniques. JF - Journal of the American Dental Association (1939) AU - Friedlander, Arthur H AU - Mahler, Michael AU - Norman, Keith M AU - Ettinger, Ronald L AD - VA (Department of Veterans Affairs) Greater Los Angeles Healthcare System, Los Angeles, Calif. 90073, USA. arthur.friedlander@med.va.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 658 EP - 669 VL - 140 IS - 6 KW - Anesthetics, Local KW - 0 KW - Antiparkinson Agents KW - Dentistry KW - Index Medicus KW - Dentist-Patient Relations KW - Drug Interactions KW - Cooperative Behavior KW - Anesthetics, Local -- administration & dosage KW - Oral Health KW - Oral Hygiene KW - Humans KW - Antiparkinson Agents -- therapeutic use KW - Parkinson Disease -- physiopathology KW - Parkinson Disease -- drug therapy KW - Dental Care for Chronically Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67317063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Parkinson+disease%3A+systemic+and+orofacial+manifestations%2C+medical+and+dental+management.&rft.au=Friedlander%2C+Arthur+H%3BMahler%2C+Michael%3BNorman%2C+Keith+M%3BEttinger%2C+Ronald+L&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2009-06-01&rft.volume=140&rft.issue=6&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=1943-4723&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-08 N1 - Date created - 2009-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Single Specialty Hospitals and Nurse Staffing Patterns AN - 57303568; 200918123 AB - Advocates of physician-owned single specialty hospitals (SSHs) maintain that, through healthy competition, SSHs pressure competitor hospitals in local markets to improve performance. This paper investigates data trends on the effects of SSH entry on a potential indicator of quality of care in general hospital competitors: nurse staffing levels. We examined registered nurse (RN) staffing from 1997 to 2004 in ten states in which there was considerable SSH entry during this period. Regression estimates used longitudinal panel data models with hospital fixed effects to compare changes in numbers of RNs in general hospitals located in markets with SSHs with general hospitals located in markets where there were no SSHs. Results indicate that hospitals located in markets with orthopedic/surgical SSH presence raised their RN nurse staffing levels. Whether or not these changes are associated with improved patient outcomes is unknown. [Copyright Sage Publications, Inc.] JF - Medical Care Research and Review AU - Carey, Kathleen AU - Burgess, James F AU - Young, Gary J AD - U.S. Department of Veterans Affairs and Boston University School of Public Health Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 307 EP - 319 PB - Sage Publications, Thousand Oaks CA VL - 66 IS - 3 SN - 1077-5587, 1077-5587 KW - hospitals specialty nurse staffing KW - Clinical outcomes KW - Competitors KW - Staffing KW - Staffing levels KW - Markets KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57303568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review&rft.atitle=Single+Specialty+Hospitals+and+Nurse+Staffing+Patterns&rft.au=Carey%2C+Kathleen%3BBurgess%2C+James+F%3BYoung%2C+Gary+J&rft.aulast=Carey&rft.aufirst=Kathleen&rft.date=2009-06-01&rft.volume=66&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558708330427 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - MCRRFH N1 - SubjectsTermNotLitGenreText - Hospitals; Markets; Staffing levels; Staffing; Competitors; Clinical outcomes DO - http://dx.doi.org/10.1177/1077558708330427 ER - TY - JOUR T1 - Relationship of Hospital Organizational Culture to Patient Safety Climate in the Veterans Health Administration AN - 57301740; 200918937 AB - Improving safety climate could enhance patient safety, yet little evidence exists regarding the relationship between hospital characteristics and safety climate. This study assessed the relationship between hospitals' organizational culture and safety climate in Veterans Health Administration (VA) hospitals nationally. Data were collected from a sample of employees in a stratified random sample of 30 VA hospitals over a 6-month period (response rate = 50%; n = 4,625). The Patient Safety Climate in Healthcare Organizations (PSCHO) and the Zammuto and Krakower surveys were used to measure safety climate and organizational culture, respectively. Higher levels of safety climate were significantly associated with higher levels of group and entrepreneurial cultures, while lower levels of safety climate were associated with higher levels of hierarchical culture. Hospitals could use these results to design specific interventions aimed at improving safety climate. [Copyright Sage Publications, Inc.] JF - Medical Care Research and Review AU - Hartmann, Christine W AU - Meterko, Mark AU - Rosen, Amy K AU - Zhao, Shibei AU - Shokeen, Priti AU - Singer, Sara AU - Gaba, David M AD - Center for Health Quality, Outcomes, and Economic Research, Bedford, MA and Boston University christine.hartmann@va.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 320 EP - 338 PB - Sage Publications, Thousand Oaks CA VL - 66 IS - 3 SN - 1077-5587, 1077-5587 KW - patient safety safety culture safety climate organizational culture survey research KW - Organizational climate KW - Safety measures KW - Patient care KW - Military hospitals KW - Organizational culture KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57301740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review&rft.atitle=Relationship+of+Hospital+Organizational+Culture+to+Patient+Safety+Climate+in+the+Veterans+Health+Administration&rft.au=Hartmann%2C+Christine+W%3BMeterko%2C+Mark%3BRosen%2C+Amy+K%3BZhao%2C+Shibei%3BShokeen%2C+Priti%3BSinger%2C+Sara%3BGaba%2C+David+M&rft.aulast=Hartmann&rft.aufirst=Christine&rft.date=2009-06-01&rft.volume=66&rft.issue=3&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558709331812 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - MCRRFH N1 - SubjectsTermNotLitGenreText - Organizational climate; Hospitals; Patient care; Organizational culture; Safety measures; Military hospitals DO - http://dx.doi.org/10.1177/1077558709331812 ER - TY - JOUR T1 - Relationship between hot flashes and distress in men receiving androgen deprivation therapy for prostate cancer AN - 57301023; 200920839 AB - Objective: Side effects of cancer treatment have been found to have a significant impact on patients' psychological well-being. Each of the primary treatment options for prostate cancer is associated with significant side effects that can have a dramatic impact on quality of life. Hot flashes are a notable side effect of androgen deprivation therapy (ADT) and a potential source of distress due to their episodic nature and low frequency in a normal aging male population. The current study sought to examine the relationship between hot flashes and cancer-related distress during the first three months of ADT. Methods: Participants were 68 men with various stages of prostate cancer scheduled to begin ADT for the first time. Study measures were completed at the beginning of treatment and 3 months later. Results: Repeated measures ANOVA indicated that men who did not experience hot flashes had a significant decrease in total cancer-related distress and avoidance over the 3-month period, while men with hot flashes exhibited no change in distress. Among men with hot flashes, results of hierarchical regression analyses indicated that a worse experience with hot flashes was a significant predictor of greater increases in intrusion and total cancer-related distress over the 3-month period. Conclusions: These results suggest that hot flashes serve to maintain levels of distress during the treatment period. Further research should extend these findings by lengthening the follow-up period and using ecological momentary assessment to refine measurement of these constructs and provide evidence for the direction of causality between hot flashes and distress. [Copyright John Wiley and Sons, Ltd.] JF - Psycho-Oncology AU - Ulloa, Erin Winters AU - Salup, Raoul AU - Patterson, Stephen G AU - Jacobsen, Paul B AD - University of South Florida, Tampa, FL, USA erin.ulloa2@va.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 598 EP - 605 PB - John Wiley, Chichester UK VL - 18 IS - 6 SN - 1057-9249, 1057-9249 KW - Body temperature KW - Men KW - Deprivation KW - Psychological distress KW - Prostatic cancer KW - Side effects KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57301023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=Relationship+between+hot+flashes+and+distress+in+men+receiving+androgen+deprivation+therapy+for+prostate+cancer&rft.au=Ulloa%2C+Erin+Winters%3BSalup%2C+Raoul%3BPatterson%2C+Stephen+G%3BJacobsen%2C+Paul+B&rft.aulast=Ulloa&rft.aufirst=Erin&rft.date=2009-06-01&rft.volume=18&rft.issue=6&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/10.1002%2Fpon.1427 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - POJCEE N1 - SubjectsTermNotLitGenreText - Body temperature; Psychological distress; Men; Side effects; Prostatic cancer; Deprivation DO - http://dx.doi.org/10.1002/pon.1427 ER - TY - JOUR T1 - Marked Increase in Biofilm-Derived Rough Pneumococcal Variants and Rifampin-Resistant Strains Not Due to hex Gene Mutations AN - 20690172; 10228981 AB - Otitis, pneumonia, and meningitis are tissue-based pneumococcal infections that can be associated with biofilms. The emergence of phenotypic rough variants, also known as acapsular small-colony variants, is essential for pneumococcal biofilm formation. These rough variants can increase nearly 100-fold in biofilms over time and can arise through single nucleotide polymorphisms (SNPs), deletions, or tandem duplications in the first gene of the capsular operon, cps3D. We detected a 100-fold increase in rifampin-resistant (Rif super(r)) mutants in biofilms compared to planktonic cultures using a nonvaccine serotype 3 strain, which is causing an increasing number of cases of otitis in the 7-valent pneumococcal conjugate vaccine era. Since both rough variants and Rif strains can arise through SNPs, they could emerge due to alteration of the mismatch repair (MMR) system. The Hex system, a pneumococcal MMR system, repairs mismatches during replication and transformation. In this study, no mutations were detected in the hexAB gene sequences among several rough variants with unique mutations in the cps3D gene. Within a hexA null mutant grown in broth, we detected only a 17.5-fold increase in rough variants compared to the wild-type parental strain. Taken together, these data suggest that mutations in the hex genes and modulation of hexA activity are unlikely to account for the generation of biofilm-derived rough variants. JF - Microbial Drug Resistance AU - McEllistrem, M C AU - Scott, J R AU - Zuniga-Castillo, J AU - Khan, SA AD - Veterans Affairs Pittsburgh Healthcare System, University Drive C, Mailstop 130-u, Pittsburgh, PA 15240, USA, mary.mcellistrem@va.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 85 EP - 90 VL - 15 IS - 2 SN - 1076-6294, 1076-6294 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA Aquaculture Abstracts; ASFA 1: Biological Sciences & Living Resources; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Transformation KW - Serotypes KW - Hex gene KW - Drug resistance KW - Disease control KW - Infection KW - Phenotypes KW - Meningitis KW - Gene deletion KW - Genes KW - Biofilms KW - mismatch repair KW - Data processing KW - Mutations KW - Replication KW - Strains KW - Nucleotides KW - Streptococcus pneumoniae KW - Single-nucleotide polymorphism KW - Otitis KW - Vaccines KW - Operons KW - Pneumonia KW - G 07880:Human Genetics KW - Q1 08587:Diseases of Cultured Organisms KW - A 01350:Microbial Resistance KW - Q3 08587:Diseases of Cultured Organisms KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20690172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Drug+Resistance&rft.atitle=Marked+Increase+in+Biofilm-Derived+Rough+Pneumococcal+Variants+and+Rifampin-Resistant+Strains+Not+Due+to+hex+Gene+Mutations&rft.au=McEllistrem%2C+M+C%3BScott%2C+J+R%3BZuniga-Castillo%2C+J%3BKhan%2C+SA&rft.aulast=McEllistrem&rft.aufirst=M&rft.date=2009-06-01&rft.volume=15&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Microbial+Drug+Resistance&rft.issn=10766294&rft_id=info:doi/10.1089%2Fmdr.2009.0866 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2014-05-05 N1 - SubjectsTermNotLitGenreText - Genes; Replication; Mutations; Disease control; Vaccines; Biofilms; Strains; Phenotypes; Nucleotides; Transformation; Serotypes; Data processing; mismatch repair; Hex gene; Drug resistance; Infection; Meningitis; Gene deletion; Single-nucleotide polymorphism; Otitis; Operons; Pneumonia; Streptococcus pneumoniae DO - http://dx.doi.org/10.1089/mdr.2009.0866 ER - TY - JOUR T1 - Endothelial cell inhibitory autoantibodies are associated with laser photocoagulation in adults from the Veterans Affairs Diabetes Trial AN - 20137303; 10254891 AB - Basic fibroblast growth factor (bFGF) is a potent endothelial cell mitogen that does not normally circulate, but increases in microalbuminuric adult type 2 diabetes mellitus. Earlier work indicated an unexpected association between low levels of plasma bFGF immunoreactivity and the subsequent 4-year need for laser treatment in 172 patients from the Veterans Affairs Diabetes Trial (mean: age, 59 years; diabetes duration, 11 years; baseline hemoglobin A sub(1c), 9.5%). In the present study, we tested for an association between endothelial cell inhibitory autoantibodies in plasma and the need for laser treatment. Inhibitory activity in endothelial cells from the immunoglobulin G fractions of plasma was significantly associated (P = .002) with low plasma bFGF immunoreactivity. There was a significant association (P = .003) between endothelial cell inhibitory autoantibodies in baseline plasma and the time to occurrence of first laser treatment after 4 years of study treatment. After adjusting for other risk factors, endothelial cell inhibitory activity greater than 90% vs less than or equal to 90% (hazard ratio, 0.2; P = .003) and low- density lipoprotein cholesterol concentration (hazard ratio, 0.98; P = .02) were each significant predictors of the time to first postrandomization laser occurrence. These results suggest that circulating autoantibodies inhibitory in endothelial cells may contribute to the need for laser treatment in adult men with advanced type 2 diabetes mellitus. Among the possible risk factors evaluated, baseline insulin use was the only variable significantly inversely (P = .02) associated with the baseline occurrence of inhibitory endothelial cell autoantibodies. It could not be determined whether insulin use may decrease the occurrence of endothelial cell inhibitory autoantibodies in advancing adult type 2 diabetes mellitus. JF - Metabolism AU - Zimering, Mark B AU - Anderson, Robert J AU - Moritz, Thomas E AU - Ge, Ling AD - Medical Service, Department of Veterans Affairs New Jersey Health Care System, Lyons, NJ 07939, USA, mark.zimering@med.va.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 882 EP - 887 PB - W.B. Saunders Company, Periodicals Order Fulfillment Dept. 6277 Sea Harbor Drive Orlando, FL 32887-4800 USA, [mailto:hhspcs@harcourt.com], [URL:http://www.wbsaunders.com] VL - 58 IS - 6 SN - 0026-0495, 0026-0495 KW - Toxicology Abstracts; Immunology Abstracts KW - Age KW - Endothelial cells KW - X 24390:Radioactive Materials KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20137303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolism&rft.atitle=Endothelial+cell+inhibitory+autoantibodies+are+associated+with+laser+photocoagulation+in+adults+from+the+Veterans+Affairs+Diabetes+Trial&rft.au=Zimering%2C+Mark+B%3BAnderson%2C+Robert+J%3BMoritz%2C+Thomas+E%3BGe%2C+Ling&rft.aulast=Zimering&rft.aufirst=Mark&rft.date=2009-06-01&rft.volume=58&rft.issue=6&rft.spage=882&rft.isbn=&rft.btitle=&rft.title=Metabolism&rft.issn=00260495&rft_id=info:doi/10.1016%2Fj.metabol.2009.02.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Endothelial cells DO - http://dx.doi.org/10.1016/j.metabol.2009.02.023 ER -