TY - JOUR T1 - Carcinogenesis by nitrosohydroxyethylurea and nitrosomethoxyethylurea in F344 rats. AN - 78207217; 3130352 AB - Nitroso-2-hydroxyethylurea and its methyl ether, nitroso-2-methoxyethylurea, were administered to male and female rats by gavage, each at two dose rates. The highest dose rate of nitrosohydroxyethylurea was 14 mg twice a week for 18 weeks, which led to death of all animals by week 34 with a variety of neoplasms, which have been observed in earlier experiments at lower doses, and included those in lung, colon, thyroid, forestomach, tongue, duodenum, jejunum, Zymbal's gland, thymus and mammary gland adenocarcinomas. At a dose 10 times smaller, the animals survived much longer, but the distribution of tumors was similar, except that there were few of the duodenum and jejunum. At an equimolar dose of nitrosomethoxyethylurea (1.6 mg, twice a week), the pattern of tumors was similar to that seen with nitrosohydroxyethylurea, including the absence of tumors in the duodenum and jejunum, although there were tumors of the colon. The rats treated with the methyl ether died earlier than those given nitrosohydroxyethylurea, indicating a greater potency of the former. At a dose of 3.2 mg twice a week, nitrosomethoxyethylurea produced the same pattern of tumors as the lower dose, but the animals died earlier. In all groups, there were more lung tumors in males than in females, and this was true to a lesser extent of the colon. The main effect of methylation of the hydroxyl group in nitrosohydroxyethylurea was to increase the potency of the carcinogen, but there was no effect on the target organ specificity of the nitrosourea. JF - Japanese journal of cancer research : Gann AU - Lijinsky, W AU - Kovatch, R M AD - Laboratory of Chemical and Physical Carcinogenesis, NCI-Frederick Cancer Research Facility, MD 21701. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 181 EP - 186 VL - 79 IS - 2 SN - 0910-5050, 0910-5050 KW - Carcinogens KW - 0 KW - 1-(2-methyoxyethyl)-1-nitrosourea KW - 108278-70-2 KW - 1-(2-hydroxyethyl)-1-nitrosourea KW - 13743-07-2 KW - DNA KW - 9007-49-2 KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Stomach Neoplasms -- chemically induced KW - Sex Factors KW - DNA -- metabolism KW - Male KW - Female KW - Structure-Activity Relationship KW - Ethylnitrosourea -- toxicity KW - Ethylnitrosourea -- metabolism KW - Neoplasms, Experimental -- chemically induced KW - Ethylnitrosourea -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78207217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Japanese+journal+of+cancer+research+%3A+Gann&rft.atitle=Carcinogenesis+by+nitrosohydroxyethylurea+and+nitrosomethoxyethylurea+in+F344+rats.&rft.au=Lijinsky%2C+W%3BKovatch%2C+R+M&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1988-02-01&rft.volume=79&rft.issue=2&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Japanese+journal+of+cancer+research+%3A+Gann&rft.issn=09105050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-14 N1 - Date created - 1988-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - H-ras p21 and peanut lectin immunoreactivity of hyperplastic, preneoplastic and neoplastic urinary bladder lesions in rats. AN - 78203548; 3130347 AB - Hyperplastic, preneoplastic and neoplastic urinary bladder lesions induced by bladder carcinogens and toxins in the rat were evaluated for immunoreactivity with polyclonal or monoclonal antibodies to H-ras p21 or binding to peanut lectin with avidin-biotin immunocytochemistry. A low proportion (less than 20%) of hyperplastic and neoplastic bladder lesions induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine and fixed in Bouin's fixative only were immunoreactive on the cell membrane with the antibodies to H-ras p21. Lectin binding was found for these lesions, as well, even in formalin-fixed tissue and for lesions induced by other carcinogens, but not in regenerative bladder hyperplasias after cyclophosphamide exposure or in bladder exposed to bladder tumor promoters. The latter lesions were also not immunoreactive with antibodies to p21. Our results suggest that this relatively simple technique might be used for identification and screening of tumors for involvement of ras oncogenes and carcinogen initiation. JF - Japanese journal of cancer research : Gann AU - Ward, J M AU - Hagiwara, A AU - Tsuda, H AU - Tatematsu, M AU - Ito, N AD - Tumor Pathology and Pathogenesis Section, National Cancer Institute, Frederick, Maryland 21701-1013. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 152 EP - 155 VL - 79 IS - 2 SN - 0910-5050, 0910-5050 KW - Lectins KW - 0 KW - Peanut Agglutinin KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Hyperplasia KW - Immunohistochemistry KW - Urinary Bladder -- pathology KW - Proto-Oncogene Proteins -- analysis KW - Urinary Bladder Neoplasms -- analysis KW - Proto-Oncogene Proteins -- immunology KW - Urinary Bladder -- analysis KW - Precancerous Conditions -- enzymology KW - Lectins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78203548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Japanese+journal+of+cancer+research+%3A+Gann&rft.atitle=H-ras+p21+and+peanut+lectin+immunoreactivity+of+hyperplastic%2C+preneoplastic+and+neoplastic+urinary+bladder+lesions+in+rats.&rft.au=Ward%2C+J+M%3BHagiwara%2C+A%3BTsuda%2C+H%3BTatematsu%2C+M%3BIto%2C+N&rft.aulast=Ward&rft.aufirst=J&rft.date=1988-02-01&rft.volume=79&rft.issue=2&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Japanese+journal+of+cancer+research+%3A+Gann&rft.issn=09105050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-14 N1 - Date created - 1988-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Voltage-activated sodium conductances in cultured normal and trisomy 16 dorsal root ganglion neurons from the fetal mouse. AN - 78176969; 2452000 AB - Current and voltage clamp recordings were made with a patch-clamp technique from large, light, dorsal root ganglia (DRG) neurons in tissue culture, derived from trisomy 16 and normal fetal mice. In a Na gradient of [52 mM]o/[28 mM]i, the action potential was accelerated, depolarization and repolarization were faster and the total Na conductance was higher in trisomic neurons. A tetrodotoxin (TTX)-sensitive, fast Na current was demonstrated, about 0.9 nA in trisomic and 0.3 nA in control neurons. The calculated mean specific membrane conductances were 0.74 mS/cm2 and 0.28 mS/cm2, respectively. A TTX-insensitive, slow Na conductance, 3-4 times the fast Na conductance and sensitive to Cd, also was demonstrated, with a 2-fold greater current density and conductance in trisomic as compared with control neurons, of 2.22 +/- 0.54 mS/cm2 and 1.26 +/- 0.09 mS/cm2, respectively. The voltage-dependence and kinetics of the TTX-insensitive, slow, Na current were similar in the two neuronal groups. The results indicate that depolarization during the action potential, in fetal mouse DRG neurons in culture, is mediated by this slow TTX-insensitive Na current. Further, acceleration of depolarization in trisomy 16 neurons is caused by a 2-fold increase in the density of the slow Na current. JF - Brain research AU - Orozco, C B AU - Epstein, C J AU - Rapoport, S I AD - National Institute on Aging, NIH, Bethesda, MD 20892. Y1 - 1988/02/01/ PY - 1988 DA - 1988 Feb 01 SP - 265 EP - 274 VL - 466 IS - 2 SN - 0006-8993, 0006-8993 KW - Ion Channels KW - 0 KW - Cobalt KW - 3G0H8C9362 KW - Tetrodotoxin KW - 4368-28-9 KW - Sodium KW - 9NEZ333N27 KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Humans KW - Mice KW - Action Potentials -- drug effects KW - Cobalt -- pharmacology KW - Tetrodotoxin -- pharmacology KW - Chromosomes, Human, Pair 16 KW - Sodium -- physiology KW - Ganglia, Spinal -- physiology KW - Ion Channels -- drug effects KW - Trisomy KW - Ganglia, Spinal -- drug effects KW - Ion Channels -- physiology KW - Sodium -- metabolism KW - Ion Channels -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78176969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Voltage-activated+sodium+conductances+in+cultured+normal+and+trisomy+16+dorsal+root+ganglion+neurons+from+the+fetal+mouse.&rft.au=Orozco%2C+C+B%3BEpstein%2C+C+J%3BRapoport%2C+S+I&rft.aulast=Orozco&rft.aufirst=C&rft.date=1988-02-01&rft.volume=466&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-27 N1 - Date created - 1988-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tranylcypromine compared with L-deprenyl in Alzheimer's disease. AN - 78149680; 3127432 AB - The authors have previously reported mild improvement of behavior and cognition in a group of 17 nondepressed patients with dementia of the Alzheimer type (DAT) treated with two doses of L-deprenyl (10 and 40 mg/day). Seven of these patients subsequently received double-blind, placebo-controlled treatment with tranylcypromine. The patients experienced significant side effects, particularly orthostatic hypotension without compensatory pulse increase, during tranylcypromine treatment. These effects were more severe than those occurring during L-deprenyl treatment, and they occurred at substantially lower doses (mean dose, 16 mg/day). These data support the role of the inhibition of monoamine oxidase type A in the development of orthostatic hypotension in patients treated with monoamine oxidase inhibitors. They also raise the question of whether the observed sensitivity to monoamine oxidase inhibition is a function of age or disease. In either case, the greater toxicity of tranylcypromine makes inferences difficult regarding the relative efficacies of these drugs in treating patients with dementia of the Alzheimer type and may limit the potential usefulness of tranylcypromine in ameliorating some symptoms of this disease. JF - Journal of clinical psychopharmacology AU - Tariot, P N AU - Sunderland, T AU - Cohen, R M AU - Newhouse, P A AU - Mueller, E A AU - Murphy, D L AD - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 23 EP - 27 VL - 8 IS - 1 SN - 0271-0749, 0271-0749 KW - Phenethylamines KW - 0 KW - Selegiline KW - 2K1V7GP655 KW - Tranylcypromine KW - 3E3V44J4Z9 KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Female KW - Selegiline -- adverse effects KW - Selegiline -- therapeutic use KW - Alzheimer Disease -- drug therapy KW - Tranylcypromine -- therapeutic use KW - Alzheimer Disease -- psychology KW - Tranylcypromine -- adverse effects KW - Phenethylamines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78149680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Factitious+hypoglycemia+due+to+surreptitious+administration+of+insulin.+Diagnosis%2C+treatment%2C+and+long-term+follow-up.&rft.au=Grunberger%2C+G%3BWeiner%2C+J+L%3BSilverman%2C+R%3BTaylor%2C+S%3BGorden%2C+P&rft.aulast=Grunberger&rft.aufirst=G&rft.date=1988-02-01&rft.volume=108&rft.issue=2&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-03 N1 - Date created - 1988-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - CR1-receptor recycling in phorbol ester-activated polymorphonuclear leucocytes. AN - 78146829; 3162434 AB - Complement-receptor type 1, CR1, which recognizes the C3b cleavage fragment of C3, is present on the membranes of human phagocytic cells, but does not mediate phagocytosis or undergo internalization unless activated by one of a variety of stimuli. Among these stimuli low doses of phorbol esters have been shown to induce a consistently increased expression of CR1, despite apparently continuous receptor internalization. We have studied the fate of internalized receptor-ligand complexes in neutrophils activated with low concentrations of phorbol dibutyrate. In our studies, we followed CR1 with either 125I-C3b, the physiologic ligand, or with 125I-Fab fragments of a monoclonal anti-CR1 antibody. We observed rapid internalization of CR1-C3b complexes by PMN treated with 10 ng/ml (1.98 x 10(-8)M) PDBu, consistent in rate and extent with previously reported results using monoclonal antibodies. The fate of the internalized ligand was studied after elution of cell-surface C3b at 0 degrees. Intracellular ligand was externalized in a time- and temperature-dependent fashion, reaching a plateau at 10-15 min. Released C3b was totally TCA precipitable and structurally unaltered, as determined by SDS-PAGE, suggesting that recycling occurs via a prelysosomal predegradative compartment. Loading the cells with chloroquine did not affect this process. A monoclonal anti-CR1 Fab probe behaved in exactly the same manner, suggesting that the recycling of intact ligand-receptor complexes takes place. The possible physiological consequences of this finding are discussed. JF - Immunology AU - Malbran, A AU - Siwik, S AU - Frank, M M AU - Fries, L F AD - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 325 EP - 330 VL - 63 IS - 2 SN - 0019-2805, 0019-2805 KW - Complement C1 KW - 0 KW - Phorbol Esters KW - Receptors, Complement KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Complement C3b KW - 80295-43-8 KW - Chloroquine KW - 886U3H6UFF KW - Index Medicus KW - Phorbol Esters -- pharmacology KW - Hot Temperature KW - Complement C3b -- immunology KW - Chloroquine -- pharmacology KW - Electrophoresis, Polyacrylamide Gel KW - Humans KW - In Vitro Techniques KW - Complement Activation -- drug effects KW - Phagocytosis KW - Time Factors KW - Neutrophils -- immunology KW - Receptors, Complement -- drug effects KW - Complement C1 -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78146829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=CR1-receptor+recycling+in+phorbol+ester-activated+polymorphonuclear+leucocytes.&rft.au=Malbran%2C+A%3BSiwik%2C+S%3BFrank%2C+M+M%3BFries%2C+L+F&rft.aulast=Malbran&rft.aufirst=A&rft.date=1988-02-01&rft.volume=63&rft.issue=2&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=00192805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-29 N1 - Date created - 1988-04-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Biochem Biophys. 1969 Nov;134(2):279-84 [4982185] J Immunol. 1985 Nov;135(5):3381-7 [2931483] J Immunol. 1979 Oct;123(4):1839-46 [573303] Biochem Biophys Res Commun. 1980 Mar 13;93(1):1-8 [7378072] J Immunol. 1980 Aug;125(2):844-9 [7391581] Methods Enzymol. 1980;70(A):142-50 [6775174] J Biol Chem. 1981 Apr 25;256(8):3995-4006 [6783652] J Exp Med. 1981 Jun 1;153(6):1615-28 [7252422] J Cell Biol. 1982 Feb;92(2):417-24 [6277962] J Immunol. 1983 Jan;130(1):370-5 [6847888] J Exp Med. 1982 Oct 1;156(4):1149-64 [7153708] J Exp Med. 1983 Jun 1;157(6):1844-54 [6854210] J Exp Med. 1983 Oct 1;158(4):1338-43 [6225825] J Clin Invest. 1983 Nov;72(5):1793-800 [6415117] J Biol Chem. 1984 Feb 10;259(3):1703-13 [6693431] J Exp Med. 1984 Jan 1;159(1):137-51 [6319529] J Cell Biol. 1984 Apr;98(4):1163-9 [6715403] Biochim Biophys Acta. 1984 Nov 13;805(3):268-76 [6148970] J Clin Invest. 1984 Nov;74(5):1566-71 [6209300] J Immunol. 1985 Mar;134(3):1851-8 [3155775] J Exp Med. 1985 May 1;161(5):912-23 [3157764] J Immunol. 1985 Aug;135(2):1325-30 [3159791] J Immunol. 1985 Oct;135(4):2673-9 [3161945] Proc Natl Acad Sci U S A. 1970 Jul;66(3):651-6 [4913206] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neuropsychological performance and treatment outcome in male alcoholics. AN - 78139855; 3279865 AB - Commonly used neuropsychological tests were administered to 91 detoxified alcoholics at the beginning of treatment. Statistically significant relationships were observed between test scores and post-treatment consumption determined 8 months after completing treatment for 72 patients. The results varied depending upon the particular measure of posttreatment consumption evaluated and the type of statistical analysis used. The most consistent relationships were often counter to the notion that increased neuropsychological performance is correlated with a more favorable treatment outcome. Neuropsychological evaluation is of limited clinical utility in predicting posttreatment alcohol consumption. JF - Alcoholism, clinical and experimental research AU - Eckardt, M J AU - Rawlings, R R AU - Graubard, B I AU - Faden, V AU - Martin, P R AU - Gottschalk, L A AD - Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 88 EP - 93 VL - 12 IS - 1 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Psychometrics KW - Male KW - Alcoholism -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Neuropsychological Tests KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78139855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Neuropsychological+performance+and+treatment+outcome+in+male+alcoholics.&rft.au=Eckardt%2C+M+J%3BRawlings%2C+R+R%3BGraubard%2C+B+I%3BFaden%2C+V%3BMartin%2C+P+R%3BGottschalk%2C+L+A&rft.aulast=Eckardt&rft.aufirst=M&rft.date=1988-02-01&rft.volume=12&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-08 N1 - Date created - 1988-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tolerance and the etiology of alcoholism: hypothesis and mechanism. AN - 78128533; 2964796 JF - Alcoholism, clinical and experimental research AU - Tabakoff, B AU - Hoffman, P L AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 184 EP - 186 VL - 12 IS - 1 SN - 0145-6008, 0145-6008 KW - Neuropeptides KW - 0 KW - Receptors, Angiotensin KW - Receptors, Vasopressin KW - Arginine Vasopressin KW - 113-79-1 KW - Index Medicus KW - Neuropeptides -- physiology KW - Drug Tolerance KW - Animals KW - Receptors, Angiotensin -- physiology KW - Humans KW - Arginine Vasopressin -- physiology KW - Brain -- physiopathology KW - Alcoholism -- physiopathology KW - Alcohol Drinking -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78128533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Tolerance+and+the+etiology+of+alcoholism%3A+hypothesis+and+mechanism.&rft.au=Tabakoff%2C+B%3BHoffman%2C+P+L&rft.aulast=Tabakoff&rft.aufirst=B&rft.date=1988-02-01&rft.volume=12&rft.issue=1&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-08 N1 - Date created - 1988-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Histopathological effects of intraoperative radiotherapy on pancreas and adjacent tissues: a postmortem analysis. AN - 78127838; 3343837 AB - Intraoperative radiotherapy (IORT) has been utilized in the treatment of resectable and unresectable pancreatic carcinoma at the National Cancer Institute. Detailed autopsy analyses of the radiation effects on the pancreas and adjacent tissues were performed on 13 patients dying at various times following therapy. IORT can induce a progressive retroperitoneal fibrosis and fibrosis of the porta hepatis in patients with resectable pancreatic carcinoma. In unresectable pancreatic carcinoma, the major expression of intraoperative irradiation with external beam irradiation is a progressive fibrosis of the pancreas with vascular sclerosis, nerve degeneration, atrophy of acinar cells, and atypical changes in the ducts of the pancreas, as well as degenerative changes of the pancreatic tumor. JF - Journal of surgical oncology AU - Hoekstra, H J AU - Restrepo, C AU - Kinsella, T J AU - Sindelar, W F AD - Surgery Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 104 EP - 108 VL - 37 IS - 2 SN - 0022-4790, 0022-4790 KW - Index Medicus KW - Adrenal Glands -- radiation effects KW - Liver -- pathology KW - Humans KW - Bile Ducts -- radiation effects KW - Aged KW - Blood Vessels -- pathology KW - Adrenal Glands -- pathology KW - Spinal Cord -- radiation effects KW - Retroperitoneal Space -- radiation effects KW - Radiotherapy Dosage KW - Intraoperative Care KW - Adult KW - Bile Ducts -- pathology KW - Blood Vessels -- radiation effects KW - Spinal Cord -- pathology KW - Retroperitoneal Space -- pathology KW - Middle Aged KW - Male KW - Liver -- radiation effects KW - Female KW - Pancreas -- pathology KW - Pancreatic Neoplasms -- radiotherapy KW - Pancreatic Neoplasms -- pathology KW - Pancreas -- radiation effects KW - Radiotherapy -- adverse effects KW - Pancreatic Neoplasms -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78127838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+surgical+oncology&rft.atitle=Histopathological+effects+of+intraoperative+radiotherapy+on+pancreas+and+adjacent+tissues%3A+a+postmortem+analysis.&rft.au=Hoekstra%2C+H+J%3BRestrepo%2C+C%3BKinsella%2C+T+J%3BSindelar%2C+W+F&rft.aulast=Hoekstra&rft.aufirst=H&rft.date=1988-02-01&rft.volume=37&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Journal+of+surgical+oncology&rft.issn=00224790&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-04 N1 - Date created - 1988-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Drug purpura due to surreptitious quinidine intake. AN - 78119299; 3341652 AB - Three patients had recurrent episodes of thrombocytopenia that resembled drug purpura, but the drug history in each case did not support the diagnosis. Although the patients specifically denied taking quinidine, serologic testing with this drug was done because the patients had access to it, and it is the commonest cause of drug purpura. Highly specific quinidine-dependent antiplatelet antibodies were found in the sera of all three patients. After being informed of the laboratory findings, the patients have had no recurrences of purpura. Serologic tests for quinidine- or quinine-dependent antibodies can help elucidate some obscure cases of purpura that may be self-induced. JF - Annals of internal medicine AU - Reid, D M AU - Shulman, N R AD - National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 206 EP - 208 VL - 108 IS - 2 SN - 0003-4819, 0003-4819 KW - Antibodies KW - 0 KW - Quinidine KW - ITX08688JL KW - Abridged Index Medicus KW - Index Medicus KW - Antibody Specificity KW - Complement Fixation Tests KW - Blood Platelets -- immunology KW - Humans KW - Aged KW - Middle Aged KW - Antibodies -- analysis KW - Male KW - Female KW - Quinidine -- immunology KW - Purpura, Thrombocytopenic -- chemically induced KW - Quinidine -- poisoning KW - Factitious Disorders -- diagnosis KW - Quinidine -- blood KW - Purpura, Thrombocytopenic -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78119299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Drug+purpura+due+to+surreptitious+quinidine+intake.&rft.au=Reid%2C+D+M%3BShulman%2C+N+R&rft.aulast=Reid&rft.aufirst=D&rft.date=1988-02-01&rft.volume=108&rft.issue=2&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-11 N1 - Date created - 1988-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Factitious hypoglycemia due to surreptitious administration of insulin. Diagnosis, treatment, and long-term follow-up. AN - 78109607; 3277509 AB - Ten patients had factitious hypoglycemia due to surreptitious insulin injections diagnosed and were followed for up to 15 years (median, 5 years; range, 2 months to 15 years). When available, demonstration of anti-insulin antibodies was the most helpful diagnostic test. Decreased plasma C-peptide levels corroborated the diagnosis. Young women (nine of ten) with knowledge of the medical profession or relatives with diabetes mellitus predominated in the sample. Five of the patients had a history of insulin-requiring diabetes mellitus. Two patients eventually committed suicide despite the best efforts at therapy. Only three of ten patients made a successful transition into productive life after the diagnosis of factitious hypoglycemia was established. Factitious hypoglycemia remains a difficult diagnosis to make, and the long-term outcome after the diagnosis is established is unpredictable. All efforts have to be made to confirm the diagnosis before the patients are approached. The confrontation is to be made by an experienced team of health care professionals who have gained the patient's confidence through an understanding but firm manner. Long-term therapy must be planned and initiated before the patient's discharge. JF - Annals of internal medicine AU - Grunberger, G AU - Weiner, J L AU - Silverman, R AU - Taylor, S AU - Gorden, P AD - Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 252 EP - 257 VL - 108 IS - 2 SN - 0003-4819, 0003-4819 KW - C-Peptide KW - 0 KW - Insulin KW - Insulin Antibodies KW - Abridged Index Medicus KW - Index Medicus KW - Insulin Antibodies -- analysis KW - C-Peptide -- blood KW - Humans KW - Adult KW - Follow-Up Studies KW - Male KW - Female KW - Factitious Disorders -- therapy KW - Insulin -- blood KW - Factitious Disorders -- diagnosis KW - Insulin -- administration & dosage KW - Hypoglycemia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78109607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Factitious+hypoglycemia+due+to+surreptitious+administration+of+insulin.+Diagnosis%2C+treatment%2C+and+long-term+follow-up.&rft.au=Grunberger%2C+G%3BWeiner%2C+J+L%3BSilverman%2C+R%3BTaylor%2C+S%3BGorden%2C+P&rft.aulast=Grunberger&rft.aufirst=G&rft.date=1988-02-01&rft.volume=108&rft.issue=2&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-11 N1 - Date created - 1988-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - IgE immunotoxins. Effect of an IgE-ricin A chain conjugate on rat skin histamine content. AN - 78096391; 2448377 AB - Immunotoxins--toxins covalently conjugated to specific antibodies--have been studied as possible agents in the treatment of cancer. The avid binding of IgE antibodies to FcR on mast cells and basophils suggested the possible use of an IgE-immunotoxin in the treatment of malignant mastocytosis or as a method to generate mast cell-depleted animals for study. To this end, the effect of a covalent conjugate of rat myeloma IgE and ricin A chain on rat cutaneous mast cells was examined in vivo. IgE-ricin A chain was capable of binding to and sensitizing cutaneous mast cells in vivo as indicated by a bluing response to intracutaneous anti-ricin A chain. IgE-ricin A chain, given either as a single dose or, even more effectively, as two split doses, significantly reduced cutaneous histamine content for 6 to 8 days. Neither a mixture of IgE and ricin A chain that were not conjugated nor the induction of cutaneous mast cell degranulation with anti-IgE affected cutaneous histamine levels. Therefore, IgE-ricin A chain produces a prolonged depletion of cutaneous histamine levels. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Slater, J E AU - Boltansky, H AU - Kaliner, M AD - Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. Y1 - 1988/02/01/ PY - 1988 DA - 1988 Feb 01 SP - 807 EP - 811 VL - 140 IS - 3 SN - 0022-1767, 0022-1767 KW - Immunotoxins KW - 0 KW - Immunoglobulin E KW - 37341-29-0 KW - Ricin KW - 9009-86-3 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Protein Biosynthesis KW - Animals KW - Mast Cells -- immunology KW - Leukemia, Experimental -- immunology KW - Electrophoresis, Polyacrylamide Gel KW - Dose-Response Relationship, Immunologic KW - Basophils -- immunology KW - Immunoglobulin E -- physiology KW - Skin -- immunology KW - Immunotoxins -- chemical synthesis KW - Immunotoxins -- isolation & purification KW - Immunotoxins -- pharmacology KW - Ricin -- pharmacology KW - Histamine Release -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78096391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=IgE+immunotoxins.+Effect+of+an+IgE-ricin+A+chain+conjugate+on+rat+skin+histamine+content.&rft.au=Slater%2C+J+E%3BBoltansky%2C+H%3BKaliner%2C+M&rft.aulast=Slater&rft.aufirst=J&rft.date=1988-02-01&rft.volume=140&rft.issue=3&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-15 N1 - Date created - 1988-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cytogenetic studies in patients with secondary leukemia/dysmyelopoietic syndrome after different treatment modalities. AN - 78096347; 3337904 AB - Cytogenetic studies of 68 patients who developed secondary leukemia (SL)/dysmyelopoietic syndrome (DMS) after extensive chemotherapy and/or radiation therapy as well as patients who developed SL/DMS without such treatment showed that those patients who received radiation alone or with chemotherapy had more extensive numerical and structural abnormalities than those who received only chemotherapy. In terms of the specific chromosomal abnormalities, there are no differences between the various treatment groups. Hypodiploidy is the most common form of aneuploidy in these patients, with the most common numerical abnormality being the loss of chromosome 7. The most common structural abnormalities involved chromosomes 3 and 5. When compared with patients with de novo leukemia and DMS, the chromosomal abnormalities in these patients are more complex and extensive. Serial studies revealed that cytogenetic abnormalities do not precede the development of hematologic changes by significant time periods. JF - Blood AU - Whang-Peng, J AU - Young, R C AU - Lee, E C AU - Longo, D L AU - Schechter, G P AU - DeVita, V T AD - Medicine Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 403 EP - 414 VL - 71 IS - 2 SN - 0006-4971, 0006-4971 KW - Antineoplastic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Lymphoma, Non-Hodgkin -- therapy KW - Chromosome Banding KW - Humans KW - Chromosome Disorders KW - Time Factors KW - Hodgkin Disease -- therapy KW - Chromosomes, Human, Pair 7 KW - Leukemia -- chemically induced KW - Chromosome Aberrations -- etiology KW - Myeloproliferative Disorders -- genetics KW - Leukemia, Radiation-Induced -- genetics KW - Myeloproliferative Disorders -- chemically induced KW - Leukemia -- genetics KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78096347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Cytogenetic+studies+in+patients+with+secondary+leukemia%2Fdysmyelopoietic+syndrome+after+different+treatment+modalities.&rft.au=Whang-Peng%2C+J%3BYoung%2C+R+C%3BLee%2C+E+C%3BLongo%2C+D+L%3BSchechter%2C+G+P%3BDeVita%2C+V+T&rft.aulast=Whang-Peng&rft.aufirst=J&rft.date=1988-02-01&rft.volume=71&rft.issue=2&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-04 N1 - Date created - 1988-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Combination chemotherapy with mastectomy or radiotherapy for stage III breast carcinoma: a Cancer and Leukemia Group B study. AN - 78095693; 3276824 AB - One hundred thirteen evaluable patients with previously untreated stage III breast carcinoma were treated with three monthly cycles of cyclophosphamide (CYC), doxorubicin (DOX), 5-fluorouracil (5-FU), vincristine (VCR), and prednisone (PRED) (CAFVP). Subsequently, 91 (81%) were deemed operable. Patients were then randomized to receive surgery or radiotherapy (RT) to determine which of these modalities afforded better local tumor control. All patients also received 2 additional years of CAFVP in a further attempt to eradicate local disease and systemic micrometastases. Forty-one of the randomized patients have relapsed. Approximately half of the initial relapses in each arm were local. The overall duration of disease control was similar following either modality, with a median of 29.2 months for surgery patients and 24.4 months for RT patients. Similarly, there was no major difference in survival related to randomized treatment with an overall median of 39 months (median follow-up 37 months). Pre- or perimenopausal status and inflammatory disease were associated with shorter disease control and survival. Treatment was generally well tolerated and toxicity was acceptable. This study demonstrates that prolonged control of stage III breast carcinoma can be achieved with combined modality therapy in which cytotoxic chemotherapy precedes and follows treatment directly primarily at the breast tumor, using either surgery or RT. Nevertheless, new regimens must be designed if significant advances that may lead to the cure of this disease are to be achieved. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Perloff, M AU - Lesnick, G J AU - Korzun, A AU - Chu, F AU - Holland, J F AU - Thirlwell, M P AU - Ellison, R R AU - Carey, R W AU - Leone, L AU - Weinberg, V AD - Cancer and Leukemia Group B, National Institutes of Health, Bethesda, MD 20892-4200. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 261 EP - 269 VL - 6 IS - 2 SN - 0732-183X, 0732-183X KW - Index Medicus KW - Neoplasm Staging KW - Random Allocation KW - Combined Modality Therapy KW - Humans KW - Adult KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Neoplasm Recurrence, Local KW - Female KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Mastectomy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Breast Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78095693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Combination+chemotherapy+with+mastectomy+or+radiotherapy+for+stage+III+breast+carcinoma%3A+a+Cancer+and+Leukemia+Group+B+study.&rft.au=Perloff%2C+M%3BLesnick%2C+G+J%3BKorzun%2C+A%3BChu%2C+F%3BHolland%2C+J+F%3BThirlwell%2C+M+P%3BEllison%2C+R+R%3BCarey%2C+R+W%3BLeone%2C+L%3BWeinberg%2C+V&rft.aulast=Perloff&rft.aufirst=M&rft.date=1988-02-01&rft.volume=6&rft.issue=2&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-24 N1 - Date created - 1988-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Molecular complexes of thyroid hormone tyrosyl rings with aromatic donors. Possible relationship to receptor protein interactions. AN - 78095109; 2828621 AB - Several lines of evidence have indicated that thyroid hormones share common molecular properties (accessible planar face and lateral halogenation) with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds of environmental importance and can modulate their toxicity. Binding of dioxin to a soluble intracellular protein (dioxin or Ah receptor) appears to be the initial step in their mechanism of toxicity and a stacking interaction model has been proposed at the molecular level. It has also been recognized that the Ah receptor and the triiodothyronine nuclear receptor share certain physical and chemical properties important in their binding interactions. In this work, we examined the possibility that thyroid hormones might also be able to bind by a stacking complexation mechanism. By use of methods based on nuclear magnetic resonance spectroscopy, selected, structurally distinct thyroid hormone analogues with widely different hormonal activities were shown to function as electron acceptors in molecular complexes with aromatic donors involving the nonphenolic or tyrosyl ring. Binding free energies for these complexes correlated well with those previously reported for the triiodothyronine (L-T3) nuclear receptor binding interaction with the same compounds. This included preference for L-T3 over thyroxine (L-T4), very favorable binding of 3,5,3'-triiodothyroacetic acid (Triac), and marked preference for L-T3 over D-T3. These results suggest that a considerable part of the structural specificity in thyroid hormone action may be mediated by the tyrosyl ring interaction. Binding ligands for the triiodothyronine nuclear receptor and the Ah receptor may share common molecular parameters in the expression of their binding activities. JF - Journal of medicinal chemistry AU - Chae, K AU - McKinney, J D AD - Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 357 EP - 362 VL - 31 IS - 2 SN - 0022-2623, 0022-2623 KW - Receptors, Aryl Hydrocarbon KW - 0 KW - Receptors, Drug KW - Receptors, Thyroid Hormone KW - Thyroid Hormones KW - Tyrosine KW - 42HK56048U KW - Index Medicus KW - Receptors, Drug -- metabolism KW - Molecular Conformation KW - Structure-Activity Relationship KW - Magnetic Resonance Spectroscopy KW - Thyroid Hormones -- pharmacology KW - Receptors, Thyroid Hormone -- metabolism KW - Tyrosine -- metabolism KW - Thyroid Hormones -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78095109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Molecular+complexes+of+thyroid+hormone+tyrosyl+rings+with+aromatic+donors.+Possible+relationship+to+receptor+protein+interactions.&rft.au=Chae%2C+K%3BMcKinney%2C+J+D&rft.aulast=Chae&rft.aufirst=K&rft.date=1988-02-01&rft.volume=31&rft.issue=2&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-16 N1 - Date created - 1988-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alpha 1-adrenergic potentiation of vasoactive intestinal peptide stimulation of rat pinealocyte adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate: evidence for a role of calcium and protein kinase-C. AN - 78094835; 2892667 AB - alpha 1-Adrenergic agonists have recently been found to potentiate vasoactive intestinal peptide (VIP) stimulation of rat pinealocyte cAMP and cGMP. alpha 1-Adrenergic agonists also elevate pineal intracellular Ca2+ [( Ca2+]i) and activate protein kinase-C. In the present study, the possible involvement of Ca2+ and protein kinase-C in the alpha 1-adrenergic potentiation of VIP-stimulated cAMP and cGMP accumulation was examined with agents that alter [Ca2+]i or activate protein kinase-C. It was found that treatment with a Ca2+ chelator or with inorganic Ca2+ channel blockers inhibited alpha 1-adrenergic potentiation of VIP-stimulated cAMP and cGMP responses. Increasing [Ca2+]i by treatment with A23187, ouabain, or K+ potentiated VIP stimulation of cAMP and cGMP response. These observations indicate that Ca2+ mediates the alpha 1-adrenergic potentiation of VIP-stimulated cAMP and cGMP accumulation, as is true for the alpha 1-adrenergic potentiation of beta-adrenergic stimulated cAMP and cGMP accumulation. Activators of protein kinase-C mimicked the large effect alpha 1-adrenergic agonists have on cAMP accumulation in VIP-treated pinealocytes and had a small effect on cGMP accumulation in VIP-treated cells. These effects were not blocked by the Ca2+ chelator EGTA. However, the effects of a protein kinase-C activator on the cGMP response in VIP-stimulated cells were amplified by K+ (15 mM) or ouabain (1 microM), presumably through an action causing an increase in [Ca2+]i. These results suggest protein kinase-C is involved in the alpha 1-adrenergic potentiation of VIP-stimulated cAMP accumulation, as is the case for the alpha 1-adrenergic potentiation of beta-adrenergic stimulated cAMP. Protein kinase-C is also involved in cGMP accumulation, provided that there is a modest increase in [Ca2+]i. JF - Endocrinology AU - Chik, C L AU - Ho, A K AU - Klein, D C AD - Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 702 EP - 708 VL - 122 IS - 2 SN - 0013-7227, 0013-7227 KW - Adrenergic alpha-Agonists KW - 0 KW - Vasoactive Intestinal Peptide KW - 37221-79-7 KW - Calcimycin KW - 37H9VM9WZL KW - Ouabain KW - 5ACL011P69 KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinase C KW - EC 2.7.11.13 KW - Cyclic GMP KW - H2D2X058MU KW - Nifedipine KW - I9ZF7L6G2L KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Potassium KW - RWP5GA015D KW - Calcium KW - SY7Q814VUP KW - Norepinephrine KW - X4W3ENH1CV KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Nifedipine -- pharmacology KW - Animals KW - Norepinephrine -- pharmacology KW - Dose-Response Relationship, Drug KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Potassium -- pharmacology KW - Calcimycin -- pharmacology KW - Drug Synergism KW - Ouabain -- pharmacology KW - Female KW - Vasoactive Intestinal Peptide -- pharmacology KW - Protein Kinase C -- metabolism KW - Calcium -- metabolism KW - Pineal Gland -- metabolism KW - Cyclic GMP -- metabolism KW - Adrenergic alpha-Agonists -- pharmacology KW - Cyclic AMP -- metabolism KW - Pineal Gland -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78094835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Detection+of+activated+proto-oncogenes+in+N-nitrosodiethylamine-induced+liver+tumors%3A+a+comparison+between+B6C3F1+mice+and+Fischer+344+rats.&rft.au=Stowers%2C+S+J%3BWiseman%2C+R+W%3BWard%2C+J+M%3BMiller%2C+E+C%3BMiller%2C+J+A%3BAnderson%2C+M+W%3BEva%2C+A&rft.aulast=Stowers&rft.aufirst=S&rft.date=1988-02-01&rft.volume=9&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-03 N1 - Date created - 1988-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Selective effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and corticosteroid on in vitro lymphocyte maturation. AN - 78092617; 3257509 AB - The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the corticosteroid dexamethasone have potent effects on lymphocyte function, although the effects of the former have not been well characterized. In the present studies murine B cell maturation was used as a model system to examine and compare the effects of TCDD and dexamethasone on cell function. Immunosuppression by TCDD and dexamethasone is mediated by binding to specific intracellular R referred to as the Ah and glucocorticoid R, respectively. Although both compounds were comparable in their ability to inhibit antibody responses to the T-independent antigen TNP-LPS, the events responsible for suppression were found to be distinct. Dexamethasone, although affecting multiple stages of B cell maturation, had its primary effect very early, manifested by inhibition of the phosphoinositide signal transduction pathway. This was evidenced by a decrease in accumulation of inositol phosphate and surface Ia antigen expression as well as an inability to enter the cell cycle after stimulation with anti-Ig. In contrast, neither early signaling events nor proliferation were affected in B cells treated with TCDD. However, TCDD inhibited Ig secretion after stimulation of B cells with T cell-replacing factor, suggesting that TCDD modulates the differentiation of B cells into plasma cells. These differential results were confirmed by monitoring the expression of surface antigens that occur on B cells, including Ia, 7D4, and PC.2, during this maturational process. Whereas dexamethasone inhibited the expression of surface antigens that occur early in maturation (Ia and 7D4), TCDD blocked only the expression of the plasma cell marker PC.2. Although TCDD altered later stages of the B cell cycle, the presence of TCDD was required at the time of initial activation to be effective, suggesting that TCDD may interfere with early cell programming. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Luster, M I AU - Germolec, D R AU - Clark, G AU - Wiegand, G AU - Rosenthal, G J AD - Immunotoxicology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1988/02/01/ PY - 1988 DA - 1988 Feb 01 SP - 928 EP - 935 VL - 140 IS - 3 SN - 0022-1767, 0022-1767 KW - Antigens, Differentiation, B-Lymphocyte KW - 0 KW - Antigens, T-Independent KW - Dioxins KW - Immunoglobulin M KW - Immunosuppressive Agents KW - Lipopolysaccharides KW - Phospholipids KW - Polychlorinated Dibenzodioxins KW - trinitrophenyl-lipopolysaccharide KW - Dexamethasone KW - 7S5I7G3JQL KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Phospholipids -- metabolism KW - Mice KW - Antigens, Differentiation, B-Lymphocyte -- analysis KW - Mice, Inbred DBA KW - Immunosuppressive Agents -- pharmacology KW - Cell Survival -- drug effects KW - Lipopolysaccharides -- immunology KW - Mice, Inbred C57BL KW - Immunoglobulin M -- biosynthesis KW - Antigens, T-Independent -- immunology KW - Antibody Formation -- drug effects KW - Cell Cycle -- drug effects KW - Female KW - Lymphocyte Activation -- drug effects KW - B-Lymphocytes -- drug effects KW - Dexamethasone -- pharmacology KW - Polychlorinated Dibenzodioxins -- pharmacology KW - B-Lymphocytes -- immunology KW - B-Lymphocytes -- metabolism KW - Dioxins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78092617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Selective+effects+of+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin+and+corticosteroid+on+in+vitro+lymphocyte+maturation.&rft.au=Luster%2C+M+I%3BGermolec%2C+D+R%3BClark%2C+G%3BWiegand%2C+G%3BRosenthal%2C+G+J&rft.aulast=Luster&rft.aufirst=M&rft.date=1988-02-01&rft.volume=140&rft.issue=3&rft.spage=928&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-15 N1 - Date created - 1988-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bupropion in depression. II. The role of metabolites in clinical outcome. AN - 78089362; 3122699 AB - We studied the steady-state pharmacokinetics of bupropion hydrochloride, a unicyclic aminoketone antidepressant, in depressed patients. The metabolites hydroxybupropion (HB), threohydrobupropion, and erythrohydrobupropion predominated over the parent compound in plasma and cerebrospinal fluid at steady state. Plasma concentrations of each metabolite correlated with cerebrospinal fluid concentrations. Higher plasma metabolite concentrations were associated with poor clinical outcome. This relationship was most striking with HB; plasma HB levels were greater than 1250 ng/mL in all five nonresponders and less than 1200 ng/mL in all seven responders. Plasma HB levels correlated with postreatment plasma homovanillic acid levels. High levels of bupropion metabolites may be associated with poor clinical outcome due to toxic effects involving dopaminergic systems. Alternatively, a curvilinear dose-response relationship may exist for bupropion metabolites. Future studies should explore the clinical utility of plasma metabolite measurements in enhancing the efficacy of treatment with bupropion. JF - Archives of general psychiatry AU - Golden, R N AU - De Vane, C L AU - Laizure, S C AU - Rudorfer, M V AU - Sherer, M A AU - Potter, W Z AD - Section on Clinical Pharmacology, National Institute of Mental Health, Bethesda, MD. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 145 EP - 149 VL - 45 IS - 2 SN - 0003-990X, 0003-990X KW - Propiophenones KW - 0 KW - hydroxybupropion KW - Bupropion KW - 01ZG3TPX31 KW - Abridged Index Medicus KW - Index Medicus KW - Half-Life KW - Double-Blind Method KW - Humans KW - Adult KW - Outcome and Process Assessment (Health Care) KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Male KW - Female KW - Propiophenones -- metabolism KW - Bupropion -- therapeutic use KW - Propiophenones -- therapeutic use KW - Propiophenones -- pharmacokinetics KW - Depressive Disorder -- drug therapy KW - Bupropion -- metabolism KW - Bupropion -- analogs & derivatives KW - Depressive Disorder -- metabolism KW - Bupropion -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78089362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Bupropion+in+depression.+II.+The+role+of+metabolites+in+clinical+outcome.&rft.au=Golden%2C+R+N%3BDe+Vane%2C+C+L%3BLaizure%2C+S+C%3BRudorfer%2C+M+V%3BSherer%2C+M+A%3BPotter%2C+W+Z&rft.aulast=Malbran&rft.aufirst=A&rft.date=1988-02-01&rft.volume=63&rft.issue=2&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=00192805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-24 N1 - Date created - 1988-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Early superoxide dismutase-sensitive event promotes neoplastic transformation in mouse epidermal JB6 cells. AN - 78086600; 2827903 AB - Evidence has been obtained that implicates the generation of reactive oxygen species as an early and critical event in the promotion of neoplastic transformation in mouse JB6 cells. The time courses for specific inhibition by CuZn-superoxide dismutase (CuZn-SOD) of the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of neoplastic transformation in JB6 cells and for changes in antioxidant enzyme activities associated with TPA-exposure were examined. The antipromoting effect of CuZn-SOD was found to be critically dependent on the time of addition of CuZn-SOD relative to the start of a 14-day exposure of cells to TPA. Treatment of JB6 P+ Clone 22 and Clone 41 cells with CuZn-SOD for 18 h before, simultaneously with or up to 1 h after exposure to TPA, all inhibited promotion of transformation maximally. Delay of addition of CuZn-SOD by 2 h or more after the start of TPA treatment resulted in a marked decrease in the promotion inhibitory effect. CuZn-SOD added 24 or 48 h after TPA had no effect on promotion of transformation. Exposure of JB6 cells to 0.2- (superoxide anion radical) generated exogenously by the aerobic xanthine oxidase reaction resulted in promotion of neoplastic transformation that was prevented by concurrent addition of CuZn-SOD. Taken together these studies provide evidence that increased superoxide anion generation within the first 2 h following TPA exposure is an essential event in promotion of transformation in JB6 cells. Upon TPA exposure, JB6 Clone 41 cells exhibited time-specific activity changes in the cellular SOD, glutathione peroxidase (GSH-Px), and catalase. SOD and GSH-Px activities were reduced to 54% and 26% respectively of basal levels within 2 h of TPA treatment. GSH-Px activity recovered to basal levels within 4 h and CuZn-SOD within 48 h. Catalase activity was maximally reduced to 50% of basal within 1 h after TPA treatment and rebounded to greater than basal levels within 4 h. It is postulated that a c-kinase-dependent event induces rapid elevation of superoxide anion following TPA exposure and that this leads to reduced activity of antioxidant enzymes. Since antipromotion by exogenous CuZn-SOD is effective only during the first 2 h following TPA exposure, this suggests that the promotion-relevant 0.2- elevation is transient. JF - Carcinogenesis AU - Nakamura, Y AU - Gindhart, T D AU - Winterstein, D AU - Tomita, I AU - Seed, J L AU - Colburn, N H AD - Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research Facility, MD 21701-1013. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 203 EP - 207 VL - 9 IS - 2 SN - 0143-3334, 0143-3334 KW - Carcinogens KW - 0 KW - Superoxides KW - 11062-77-4 KW - Glutathione Peroxidase KW - EC 1.11.1.9 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Mice KW - Glutathione Peroxidase -- antagonists & inhibitors KW - Cell Line KW - Superoxide Dismutase -- antagonists & inhibitors KW - Cell Transformation, Neoplastic -- drug effects KW - Cell Transformation, Neoplastic -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78086600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Japanese+journal+of+cancer+research+%3A+Gann&rft.atitle=H-ras+p21+and+peanut+lectin+immunoreactivity+of+hyperplastic%2C+preneoplastic+and+neoplastic+urinary+bladder+lesions+in+rats.&rft.au=Ward%2C+J+M%3BHagiwara%2C+A%3BTsuda%2C+H%3BTatematsu%2C+M%3BIto%2C+N&rft.aulast=Ward&rft.aufirst=J&rft.date=1988-02-01&rft.volume=79&rft.issue=2&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Japanese+journal+of+cancer+research+%3A+Gann&rft.issn=09105050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-02 N1 - Date created - 1988-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Detection of activated proto-oncogenes in N-nitrosodiethylamine-induced liver tumors: a comparison between B6C3F1 mice and Fischer 344 rats. AN - 78081994; 2827904 AB - DNA from B6C3F1 mouse and Fischer 344 rat liver tumors induced by N-nitrosodiethylamine (DEN) were examined for the ability to induce morphological transformation of NIH3T3 cells. DNAs from 14 of 33 of the mouse liver tumors induced by a single injection of DEN at 12 or 15 days of age were positive in this assay while DNA from only one of 28 DEN-induced rat liver tumors was active. Southern blot analysis of the NIH3T3 transformants derived from the mouse liver tumors revealed amplified and/or rearranged restriction fragments homologous to the H-ras proto-oncogene. DNA from two independent foci induced by the rat tumor DNA did not hybridize to probes for members of the ras gene family or c-raf. Activating mutations in the H-ras genes from the DEN-induced mouse liver tumors were characterized by selective oligonucleotide hybridization and the detection of a new XbaI restriction site by Southern blot analysis. In activated H-ras genes from the DEN-induced mouse liver tumor DNA, seven of 14 had a CG----AT transversion at the first base of the 61st codon, three of 14 had an AT----GC transition and four of 14 had the AT----TA transversion at the second base of codon 61. This spectrum of mutations is very similar to that recently observed in activated H-ras genes found in spontaneously occurring B6C3F1 mouse liver tumors. Taken together, the data suggest that the DEN-induced rat and mouse liver carcinogenesis may involve genetic targets other than or in addition to the H-ras gene. JF - Carcinogenesis AU - Stowers, S J AU - Wiseman, R W AU - Ward, J M AU - Miller, E C AU - Miller, J A AU - Anderson, M W AU - Eva, A AD - National Institute of Environmental Health Sciences, Laboratory of Biochemical Risk Analysis, Research Triangle Park, NC 27709. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 271 EP - 276 VL - 9 IS - 2 SN - 0143-3334, 0143-3334 KW - Codon KW - 0 KW - DNA, Neoplasm KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - DNA Restriction Enzymes KW - EC 3.1.21.- KW - Index Medicus KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Mice KW - Nucleic Acid Hybridization KW - Mutation KW - Male KW - Cell Transformation, Neoplastic KW - Liver Neoplasms, Experimental -- genetics KW - Transfection KW - Liver Neoplasms, Experimental -- chemically induced KW - DNA, Neoplasm -- genetics KW - Proto-Oncogenes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78081994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Detection+of+activated+proto-oncogenes+in+N-nitrosodiethylamine-induced+liver+tumors%3A+a+comparison+between+B6C3F1+mice+and+Fischer+344+rats.&rft.au=Stowers%2C+S+J%3BWiseman%2C+R+W%3BWard%2C+J+M%3BMiller%2C+E+C%3BMiller%2C+J+A%3BAnderson%2C+M+W%3BEva%2C+A&rft.aulast=Stowers&rft.aufirst=S&rft.date=1988-02-01&rft.volume=9&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-02 N1 - Date created - 1988-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Circulating glycosaminoglycan anticoagulants associated with suramin treatment. AN - 78080404; 3337895 AB - A complex coagulopathy appeared in three women receiving suramin as treatment for metastatic adrenocortical carcinoma. Although hepatocellular dysfunction accounted for some of the abnormality, a unique feature of the coagulopathy was the presence of an inhibitor of the thrombin clotting time. The potency of this circulating anticoagulant increased markedly during exacerbations of hepatic injury. The anticoagulant was removed from plasma samples from two of the patients by passage over a column of diethylaminoethyl (DEAE)-Sephacel. It eluted from the DEAE at salt concentrations that removed "high-charge" glycosaminoglycans. Elimination of the purified anticoagulant activity in vitro required a combination of heparitinase and chondroitinase ABC, suggesting that the activity was mediated by both heparan sulfate and dermatan sulfate. Suramin is hypothesized to inhibit enzymes that normally degrade glycosaminoglycans, resulting in accumulation of these substances, which are released from the liver into the circulation during periods of hepatic injury. JF - Blood AU - Horne, M K AU - Stein, C A AU - LaRocca, R V AU - Myers, C E AD - Clinical Pathology Department, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 273 EP - 279 VL - 71 IS - 2 SN - 0006-4971, 0006-4971 KW - Anticoagulants KW - 0 KW - Glycosaminoglycans KW - Suramin KW - 6032D45BEM KW - Abridged Index Medicus KW - Index Medicus KW - Liver Diseases -- blood KW - Electrophoresis KW - Chromatography, DEAE-Cellulose KW - Humans KW - Blood Coagulation -- drug effects KW - In Vitro Techniques KW - Adult KW - Female KW - Glycosaminoglycans -- pharmacology KW - Blood Coagulation Disorders -- chemically induced KW - Suramin -- adverse effects KW - Anticoagulants -- blood KW - Glycosaminoglycans -- blood KW - Suramin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78080404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Circulating+glycosaminoglycan+anticoagulants+associated+with+suramin+treatment.&rft.au=Horne%2C+M+K%3BStein%2C+C+A%3BLaRocca%2C+R+V%3BMyers%2C+C+E&rft.aulast=Horne&rft.aufirst=M&rft.date=1988-02-01&rft.volume=71&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-04 N1 - Date created - 1988-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reduction of doxorubicin cytotoxicity by ouabain: correlation with topoisomerase-induced DNA strand breakage in human and hamster cells. AN - 78034422; 2825982 AB - The cardiac glycoside ouabain, which is a specific inhibitor of the Na+,K+-pump, confers dramatic protection from the cytotoxic effects of doxorubicin (Adriamycin). This effect was documented in cultured A549 cells (human lung adenocarcinoma). CCL210 cells (human fibroblasts), and V79 cells (hamster fibroblasts). Maximum protection from doxorubicin cytotoxicity was achieved using 1 microM ouabain for A549 and CCL210 cells and 300 microM ouabain for V79 cells. These concentrations correlated well with the concentrations of ouabain required to induce Na+,K+-pump blockade, which was assessed using the K+ analogue 86Rb+. This suggests that protection is mediated by pump blockade. Addition of ouabain at the same time as doxorubicin was just as protective as preincubation with ouabain for an hour, demonstrating that the ouabain acts rapidly. Ouabain treatment affected neither influx nor efflux of doxorubicin. Ouabain also had no effect on verapamil-induced inhibition of doxorubicin efflux. However, ouabain partially blocked the verapamil-induced potentiation of the cytotoxic effects of doxorubicin. Therefore, ouabain does not protect by affecting intracellular doxorubicin levels. Fluorescence microscopy showed that the ability of doxorubicin to reach the nucleus was not influenced by ouabain. Alkaline elution studies demonstrated that ouabain greatly decreased doxorubicin-induced DNA strand breakage. Protection from cytotoxicity correlated closely with this decrease in strand breakage. These studies suggest that the stabilization of DNA-topoisomerase II complexes is closely linked to the mechanism of doxorubicin cytotoxicity and that this stabilization is influenced by the intracellular ionic milieu. JF - Cancer research AU - Lawrence, T S AD - Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988/02/01/ PY - 1988 DA - 1988 Feb 01 SP - 725 EP - 730 VL - 48 IS - 3 SN - 0008-5472, 0008-5472 KW - Ouabain KW - 5ACL011P69 KW - Doxorubicin KW - 80168379AG KW - DNA KW - 9007-49-2 KW - DNA Topoisomerases, Type II KW - EC 5.99.1.3 KW - Index Medicus KW - Animals KW - Tumor Cells, Cultured KW - Cell Survival -- drug effects KW - Humans KW - DNA -- metabolism KW - Cell Line KW - Cricetinae KW - Biological Transport -- drug effects KW - DNA Damage KW - Doxorubicin -- antagonists & inhibitors KW - DNA Topoisomerases, Type II -- metabolism KW - Doxorubicin -- toxicity KW - Ouabain -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78034422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Reduction+of+doxorubicin+cytotoxicity+by+ouabain%3A+correlation+with+topoisomerase-induced+DNA+strand+breakage+in+human+and+hamster+cells.&rft.au=Lawrence%2C+T+S&rft.aulast=Lawrence&rft.aufirst=T&rft.date=1988-02-01&rft.volume=48&rft.issue=3&rft.spage=725&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cytogenetic changes in rat tracheal epithelial cells during early stages of carcinogen-induced neoplastic progression. AN - 78033358; 3335032 AB - The cytogenetic changes in enhanced growth (EG) variants of rat tracheal epithelial cells in culture were examined. These variants which are detectable at 35 days after carcinogen exposure are the first phenotypic alteration in the multistep neoplastic process studied in this model system. Karyotypic analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced EG variants at Day 35 was made possible by the development of an in situ method of cytogenetic analysis on intact colonies containing too few cells for conventional chromosome preparation methods. Of the transformed EG variant colonies in both control and N-methyl-N'-nitro-N-nitrosoguanidine-treated groups, 62-78% had abnormal karyotypes which included numerical and structural changes. There were no specific chromosome changes, although aberrations of chromosomes 3 and 4 were recurrently observed. However, some colonies of even the most morphologically transformed EG variants were composed of only diploid cells. To confirm this finding 10 EG variant colonies were bisected and half of the clone was prepared for chromosome analysis and the other half was subcultured to measure the clonogenicity and karyotypes of the cells. Cells from 3 colonies plated very poorly on 3T3 feeders and therefore no karyotypic analysis of the colony-forming cells was possible; the cells of the 3 parental colonies were diploid. Three other parental colonies were predominantly diploid (80-90%) but upon replating the resultant daughter colonies had progressively smaller fractions of diploid cells indicating a selection for cells with abnormal karyotypes. When more selective conditions were used (i.e., growth after removal of the feeder cells), the percentage of abnormal cells increased even further. In one case the parental cells had a karyotypic alteration in the long arm of chromosome 4 and this karyotypic alteration was accentuated in the daughter colonies. Thus, selection of cells with increased growth ability upon subculturing or growth in the absence of feeder cells (properties associated with the acquisition of immortality) resulted in concomitant selection for cells with abnormal karyotypes. Since some of the carcinogen-induced rat tracheal epithelial cells expressing the EG variant phenotype were diploid, it is possible that the first step in this transformation process is an epigenetic change. However, most of the diploid cells became terminal. The aneuploid subpopulations present in these colonies have a selective growth advantage and comprise the cell compartment that expresses continued growth, immortality, and ultimately tumorigenicity. JF - Cancer research AU - Oshimura, M AU - Fitzgerald, D J AU - Kitamura, H AU - Nettesheim, P AU - Barrett, J C AD - Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988/02/01/ PY - 1988 DA - 1988 Feb 01 SP - 702 EP - 708 VL - 48 IS - 3 SN - 0008-5472, 0008-5472 KW - Methylnitronitrosoguanidine KW - 12H3O2UGSF KW - Index Medicus KW - Rats KW - Karyotyping KW - Animals KW - Aneuploidy KW - Chromosome Banding KW - Neoplastic Stem Cells -- pathology KW - In Vitro Techniques KW - Cell Transformation, Neoplastic -- drug effects KW - Epithelium -- pathology KW - Time Factors KW - Trachea -- pathology KW - Chromosome Aberrations KW - Tumor Cells, Cultured -- pathology KW - Precancerous Conditions -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78033358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Cytogenetic+changes+in+rat+tracheal+epithelial+cells+during+early+stages+of+carcinogen-induced+neoplastic+progression.&rft.au=Oshimura%2C+M%3BFitzgerald%2C+D+J%3BKitamura%2C+H%3BNettesheim%2C+P%3BBarrett%2C+J+C&rft.aulast=Oshimura&rft.aufirst=M&rft.date=1988-02-01&rft.volume=48&rft.issue=3&rft.spage=702&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Decontamination and disposal of nitrosoureas and related N-nitroso compounds. AN - 78021504; 3335019 AB - An improved procedure for chemically decontaminating residues of nitrosoureas and related N-nitroso compounds ("nitrosamides") commonly used in the cancer research laboratory is proposed. Treatment of accumulated wastes with aluminum:nickel alloy powder while progressively increasing the basicity of the medium consistently led to at least 99.98% destruction of each nitrosamide tested. Hazardous diazoalkanes were never detected in yields of greater than 0.1%. The mutagenicity of the completed reaction mixtures was never more than 3 times background except when the N-nitroso compound contained a 2-chloroethyl group. In most cases, the completeness of reaction could be determined chromatographically, not only to demonstrate the disappearance of the starting N-nitroso compound, but also to follow production of identifiable products in sufficient abundance to account for the starting material destroyed; none of the organic products observed was mutagenic in any of the four tester strains used. The procedure described herein proved reliable in two checker laboratories besides our own when applied to mixtures of seven N-nitroso compounds: N-methyl-N-nitroso-p-toluene-sulfonamide; N-methyl-N-nitrosourethane; N-methyl-N-nitrosourea; N-methyl-N'-nitro-N-nitrosoguanidine; N-ethyl-N-nitrosourea; N-ethyl-N'-nitro-N-nitrosoguanidine; and N-ethyl-N-nitrosourethane. All of the other procedures investigated for destruction of nitrosamides, including the widely used approach of dissolving the nitrosamides in alkali, were associated with important disadvantages. JF - Cancer research AU - Lunn, G AU - Sansone, E B AU - Andrews, A W AU - Keefer, L K AD - Environmental Control and Research Program, National Cancer Institute, Frederick Cancer Research Facility, Maryland 21701. Y1 - 1988/02/01/ PY - 1988 DA - 1988 Feb 01 SP - 522 EP - 526 VL - 48 IS - 3 SN - 0008-5472, 0008-5472 KW - Hazardous Waste KW - 0 KW - Nitroso Compounds KW - Nitrosourea Compounds KW - Index Medicus KW - Environmental Pollution -- prevention & control KW - Chemistry KW - Chemical Phenomena UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78021504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Decontamination+and+disposal+of+nitrosoureas+and+related+N-nitroso+compounds.&rft.au=Lunn%2C+G%3BSansone%2C+E+B%3BAndrews%2C+A+W%3BKeefer%2C+L+K&rft.aulast=Lunn&rft.aufirst=G&rft.date=1988-02-01&rft.volume=48&rft.issue=3&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human immunodeficiency virus infection among patients attending clinics for sexually transmitted diseases. AN - 78076266; 3336411 AB - To assess the prevalence and associated risk factors for human immunodeficiency virus (HIV) infection in patients attending inner-city clinics for sexually transmitted diseases in Baltimore, we screened 4028 patients anonymously, of whom 209 (5.2 percent) were seropositive for HIV. HIV-seropositivity rates were higher among men (6.3 percent) than women (3.0 percent) (P less than 0.001) and among blacks (5.0 percent) than whites (1.2 percent) (P less than 0.02). Among men, but not women, HIV seroprevalence increased markedly and steadily up to the age of 40. In men, HIV seropositivity was independently associated with increased age, black race, a history of homosexual contact, and the use of parenteral drugs. In women, a history of parenteral drug use or of being a sexual partner of a bisexual man or parenteral drug user were independently predictive of HIV seropositivity. In men, HIV seropositivity was also associated with a history of syphilis or a reactive serologic test for syphilis, and in women, with a history of genital warts. Since these associations were independent of the type and number of reported sexual partners, they raise the possibility that sexually transmitted diseases that disrupt epithelial surfaces may be important in the transmissibility of HIV. In addition, on a self-administered questionnaire, one third of HIV-infected men and one half of infected women did not acknowledge previous high-risk behavior for HIV exposure. These data suggest that patients at clinics for sexually transmitted diseases represent a group at high risk for HIV infection, and that screening, counseling, and intensive education should be offered to all patients attending such clinics. JF - The New England journal of medicine AU - Quinn, T C AU - Glasser, D AU - Cannon, R O AU - Matuszak, D L AU - Dunning, R W AU - Kline, R L AU - Campbell, C H AU - Israel, E AU - Fauci, A S AU - Hook, E W AD - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Md. Y1 - 1988/01/28/ PY - 1988 DA - 1988 Jan 28 SP - 197 EP - 203 VL - 318 IS - 4 SN - 0028-4793, 0028-4793 KW - Abridged Index Medicus KW - Index Medicus KW - Population KW - AIDS/HIV KW - United States KW - Measurement KW - Laboratory Examinations And Diagnoses KW - Programs KW - Research Methodology KW - Sex Behavior KW - Organization And Administration KW - Health KW - Delivery Of Health Care KW - Correlation Studies KW - Developed Countries KW - Population At Risk KW - Hiv Infections KW - Population Characteristics KW - Acquired Immunodeficiency Syndrome--prevention and control KW - Demographic Factors KW - Maryland KW - Diseases KW - Data Analysis KW - Infections KW - Health Facilities KW - Reproductive Tract Infections KW - North America KW - Americas KW - Statistical Studies KW - Research Report KW - Studies KW - Program Activities KW - Outpatient Clinic KW - Physical Examinations And Diagnoses KW - Northern America KW - Behavior KW - Bacterial And Fungal Diseases KW - Viral Diseases KW - Risk Factors KW - Sexually Transmitted Diseases KW - Incidence KW - Examinations And Diagnoses KW - Developing Countries KW - Clinic Activities KW - Prevalence KW - Biology KW - Sex Factors KW - Humans KW - African Americans KW - Aged KW - Child KW - Homosexuality KW - Sexual Behavior KW - Acquired Immunodeficiency Syndrome -- transmission KW - Adult KW - Substance-Related Disorders KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Sexually Transmitted Diseases -- complications KW - HIV Seropositivity -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78076266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Human+immunodeficiency+virus+infection+among+patients+attending+clinics+for+sexually+transmitted+diseases.&rft.au=Quinn%2C+T+C%3BGlasser%2C+D%3BCannon%2C+R+O%3BMatuszak%2C+D+L%3BDunning%2C+R+W%3BKline%2C+R+L%3BCampbell%2C+C+H%3BIsrael%2C+E%3BFauci%2C+A+S%3BHook%2C+E+W&rft.aulast=Quinn&rft.aufirst=T&rft.date=1988-01-28&rft.volume=318&rft.issue=4&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The MAK11 protein is essential for cell growth and replication of M double-stranded RNA and is apparently a membrane-associated protein. AN - 78048179; 2826479 AB - MAK11 is a gene necessary for the maintenance of killer M1 double-stranded RNA, but not for other cellular double-stranded RNAs (L-A, L-BC, T, W). The DNA sequence of this gene revealed a 1407-base pair open reading frame, which corresponds to a 54-kDa protein. The C-terminal region is lysine-rich and is necessary for mak11-complementing activity. The N-terminal 24 amino acids of the open reading frame include 16 hydrophobic amino acids, 4 basic residues, and 4 neutral amino acids; this sequence could span a membrane. We constructed a MAK11-lacZ fusion that includes the entire MAK11 protein and complements the mak11-1 mutation. The fusion protein was localized in a membrane fraction as shown by centrifugation in Percoll gradients. The fusion protein could be released from the membrane fraction by salt washing. Western blotting of protein, isolated from the membrane fraction and purified by p-aminophenyl-beta-D-thiogalactoside-agarose column chromatography, revealed a fusion protein monomer of 170 kDa which agrees with the predicted molecular weight. While the mak11-1 mutation results in specific loss of M1 double-stranded RNA without any apparent growth defect, replacing a 792-base pair internal EcoRV fragment of MAK11 with the URA3 gene (gene disruption) resulted in a lethal mutation. JF - The Journal of biological chemistry AU - Icho, T AU - Wickner, R B AD - Section on Genetics of Simple Eukaryotes, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892. Y1 - 1988/01/25/ PY - 1988 DA - 1988 Jan 25 SP - 1467 EP - 1475 VL - 263 IS - 3 SN - 0021-9258, 0021-9258 KW - Fungal Proteins KW - 0 KW - KHR1 protein, S cerevisiae KW - Killer Factors, Yeast KW - Membrane Glycoproteins KW - Mycotoxins KW - RNA, Double-Stranded KW - RNA, Fungal KW - Recombinant Fusion Proteins KW - Saccharomyces cerevisiae Proteins KW - DNA Restriction Enzymes KW - EC 3.1.21.- KW - Index Medicus KW - Saccharomyces cerevisiae -- genetics KW - Recombinant Fusion Proteins -- analysis KW - Base Sequence KW - DNA Restriction Enzymes -- metabolism KW - RNA, Fungal -- biosynthesis KW - Recombinant Fusion Proteins -- isolation & purification KW - RNA, Double-Stranded -- biosynthesis KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Cloning, Molecular KW - Mycotoxins -- genetics KW - Membrane Glycoproteins -- analysis KW - Fungal Proteins -- genetics KW - Fungal Proteins -- analysis KW - Mycotoxins -- analysis KW - Membrane Glycoproteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78048179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=The+MAK11+protein+is+essential+for+cell+growth+and+replication+of+M+double-stranded+RNA+and+is+apparently+a+membrane-associated+protein.&rft.au=Icho%2C+T%3BWickner%2C+R+B&rft.aulast=Icho&rft.aufirst=T&rft.date=1988-01-25&rft.volume=263&rft.issue=3&rft.spage=1467&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-25 N1 - Date created - 1988-02-25 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - J03506; GENBANK N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Deletional analysis of the promoter region of the human transferrin receptor gene. AN - 19626128; 8740168 AB - Fragments of human genomic DNA corresponding to the promoter region of the gene for the transferrin receptor have been cloned upstream of the bacterial gene for chloramphenicol acetyltransferase and these constructs used to assess promoter activity following transfection into a human rhabdomyosarcoma cell line. Progressive 5' deletions as well as internal linker-substitution constructs support a critical role in gene expression of a sequence element approximately 70 bp upstream of the mRNA start site. In this region, the receptor gene was found to contain 11bp that are identical to a segment of the enhancers of polyoma virus and adenovirus. A fragment encompassing this element was shown to increase gene expression when the fragment was placed in either orientation upstream of the remainder of the transferrin receptor promoter but the same fragment did not activate an enhancer-less SV40 promoter. Removal from within the receptor promoter of three potential binding sites for the transcription factor Sp1 did not decrease the promoter's activity. Images JF - Nucleic Acids Research AU - Casey, J L AU - Di Jeso, B AU - Rao, K K AU - Rouault, T A AU - Klausner, R D AU - Harford, J B AD - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892. Y1 - 1988/01/25/ PY - 1988 DA - 1988 Jan 25 SP - 629 EP - 646 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 16 IS - 2 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Adenovirus KW - Polyomavirus KW - Gene expression KW - Promoters KW - Sp1 protein KW - Enhancers KW - Chloramphenicol O-acetyltransferase KW - Gene deletion KW - Transferrin receptors KW - Transfection KW - Transcription factors KW - Simian virus 40 KW - DNA KW - genomics KW - Rhabdomyosarcoma KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA KW - V 22310:Genetics, Taxonomy & Structure KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19626128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Deletional+analysis+of+the+promoter+region+of+the+human+transferrin+receptor+gene.&rft.au=Casey%2C+J+L%3BDi+Jeso%2C+B%3BRao%2C+K+K%3BRouault%2C+T+A%3BKlausner%2C+R+D%3BHarford%2C+J+B&rft.aulast=Casey&rft.aufirst=J&rft.date=1988-01-25&rft.volume=16&rft.issue=2&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Enhancers; Sp1 protein; Promoters; Gene deletion; Chloramphenicol O-acetyltransferase; Transferrin receptors; Transfection; Transcription factors; DNA; genomics; Rhabdomyosarcoma; Simian virus 40; Adenovirus; Polyomavirus ER - TY - JOUR T1 - Differences in platelet enzyme activity between alcoholics and nonalcoholics. AN - 78085462; 3336400 AB - Blood platelets are an accessible tissue that reflects the activity of many enzymes found in the brain. To investigate the possible effect on such enzymes of long-term consumption of large quantities of ethanol, we assayed the activities of two enzymes, monoamine oxidase and adenylate cyclase, in platelet membranes of men with alcoholism and controls matched for sex and age. We also compared these two groups in terms of the inhibition of platelet monoamine oxidase activity by ethanol in vitro (400 mM), and in terms of the stimulation of adenylate cyclase activity by various agents. There was no significant difference in monoamine oxidase activity between the alcoholics and the controls. However, the inhibition of monoamine oxidase by ethanol was significantly higher in the platelets of alcoholics. The basal activity of adenylate cyclase was the same in platelets from the alcoholics and the controls, but the platelet adenylate cyclase activity after stimulation with guanine nucleotide, cesium fluoride, or prostaglandin E1 was significantly lower in alcoholics. These differences were not associated with age, race, smoking, or illicit drug use, and there was no significant correlation with the duration of problems with alcohol. The changes were long-lasting; cesium fluoride-stimulated adenylate cyclase activity was lower in alcoholic subjects who had abstained from alcohol for one to four years. Discriminant analysis showed that the use of values for the inhibition of monoamine oxidase activity by ethanol and cesium fluoride-stimulated adenylate cyclase activity correctly classified 75 percent of the alcoholics and 73 percent of the controls. These measures may be of value either as indexes of excessive alcohol consumption or as an indication of a predisposition to alcoholism. JF - The New England journal of medicine AU - Tabakoff, B AU - Hoffman, P L AU - Lee, J M AU - Saito, T AU - Willard, B AU - De Leon-Jones, F AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md 20892. Y1 - 1988/01/21/ PY - 1988 DA - 1988 Jan 21 SP - 134 EP - 139 VL - 318 IS - 3 SN - 0028-4793, 0028-4793 KW - Adenylyl Cyclase Inhibitors KW - 0 KW - Monoamine Oxidase Inhibitors KW - Cesium KW - 1KSV9V4Y4I KW - Ethanol KW - 3K9958V90M KW - Monoamine Oxidase KW - EC 1.4.3.4 KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Fluorides KW - Q80VPU408O KW - cesium fluoride KW - T76A371HJR KW - Abridged Index Medicus KW - Index Medicus KW - Cesium -- pharmacology KW - Smoking -- blood KW - Cell Membrane -- enzymology KW - Ethanol -- pharmacology KW - Humans KW - Continental Population Groups KW - Adult KW - Time Factors KW - Monoamine Oxidase Inhibitors -- pharmacology KW - Male KW - Alcoholism -- enzymology KW - Blood Platelets -- enzymology KW - Adenylyl Cyclases -- blood KW - Monoamine Oxidase -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78085462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Differences+in+platelet+enzyme+activity+between+alcoholics+and+nonalcoholics.&rft.au=Tabakoff%2C+B%3BHoffman%2C+P+L%3BLee%2C+J+M%3BSaito%2C+T%3BWillard%2C+B%3BDe+Leon-Jones%2C+F&rft.aulast=Tabakoff&rft.aufirst=B&rft.date=1988-01-21&rft.volume=318&rft.issue=3&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-04 N1 - Date created - 1988-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT). AN - 78079476; 2891981 AB - Five dose regimens of 2',3'-dideoxycytidine (ddC) were administered, intravenously for 2 weeks then orally for 4 or more weeks, to 20 patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). ddC was well absorbed from the gut and crossed the blood-brain barrier. 10 of the 15 patients who received 0.03-0.09 mg/kg every 4 h had increases in their absolute number of T4+ T cells at week 2 (p less than 0.05), though in many these rises were not sustained. 11 of 13 evaluable patients had a fall in their serum human immunodeficiency virus (HIV)p24 antigen by week 2 of therapy (p less than 0.01); in 4 patients the p24 antigen subsequently rose to baseline while in others the decline was sustained. Dose-related toxic effects included cutaneous eruptions, fever, mouth sores, thrombocytopenia, and neutropenia. A reversible painful peripheral neuropathy developed in 10 patients after 6-14 weeks' treatment. These results suggest that ddC has activity against HIV in vivo and has a different toxicity profile from that of zidovudine (AZT). 6 patients with AIDS or ARC were given an alternating regimen of oral AZT (200 mg every 4 h for 7 days) and oral ddC (0.03 mg/kg every 4 h for 7 days). The regimen was well tolerated, and the 5 patients who completed 9 or more weeks of treatment had sustained rises in their T4+ T cells and/or falls in p24 antigen. JF - Lancet (London, England) AU - Yarchoan, R AU - Perno, C F AU - Thomas, R V AU - Klecker, R W AU - Allain, J P AU - Wills, R J AU - McAtee, N AU - Fischl, M A AU - Dubinsky, R AU - McNeely, M C AD - National Cancer Institute, Bethesda, Maryland. Y1 - 1988/01/16/ PY - 1988 DA - 1988 Jan 16 SP - 76 EP - 81 VL - 1 IS - 8577 SN - 0140-6736, 0140-6736 KW - Deoxycytidine KW - 0W860991D6 KW - Zidovudine KW - 4B9XT59T7S KW - Zalcitabine KW - 6L3XT8CB3I KW - Thymidine KW - VC2W18DGKR KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Drug Therapy, Combination KW - HIV -- drug effects KW - Drug Evaluation KW - Drug Administration Schedule KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Thymidine -- administration & dosage KW - Deoxycytidine -- analogs & derivatives KW - AIDS-Related Complex -- drug therapy KW - Deoxycytidine -- therapeutic use KW - Deoxycytidine -- administration & dosage KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - Thymidine -- therapeutic use KW - Thymidine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78079476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Molecular+complexes+of+thyroid+hormone+tyrosyl+rings+with+aromatic+donors.+Possible+relationship+to+receptor+protein+interactions.&rft.au=Chae%2C+K%3BMcKinney%2C+J+D&rft.aulast=Chae&rft.aufirst=K&rft.date=1988-02-01&rft.volume=31&rft.issue=2&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-17 N1 - Date created - 1988-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex. AN - 78116913; 3278811 AB - The T cell antigen receptor is composed of two variable chains (alpha and beta, termed Ti), which confer ligand specificity, and five constant chains (gamma, delta, epsilon, zeta, and p21, collectively termed CD3) whose functions are poorly understood. To explore the roles of the individual CD3 components, an antigen-specific murine T cell hybridoma was chemically mutagenized and antigen-induced growth inhibition was used to select CD3/Ti expression variants. One variant produced all CD3/Ti components except CD3-zeta and was able to express small amounts of surface CD3/Ti. This variant failed to respond normally to either antigen or a mitogenic anti-Thy-1 antibody. Surprisingly, in the absence of CD3-zeta, direct cross-linking of the partial receptor induced both phosphatidylinositol hydrolysis and interleukin 2 production. These data indicate that CD3-zeta determines the normal intracellular fate of the T cell antigen receptor and is likely to play an important role in physiologically relevant transmembrane signaling. JF - Cell AU - Sussman, J J AU - Bonifacino, J S AU - Lippincott-Schwartz, J AU - Weissman, A M AU - Saito, T AU - Klausner, R D AU - Ashwell, J D AD - Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988/01/15/ PY - 1988 DA - 1988 Jan 15 SP - 85 EP - 95 VL - 52 IS - 1 SN - 0092-8674, 0092-8674 KW - Antibodies, Monoclonal KW - 0 KW - Interleukin-2 KW - Phosphatidylinositols KW - Receptors, Antigen, T-Cell KW - Index Medicus KW - Phosphatidylinositols -- metabolism KW - Animals KW - Hybridomas KW - Interleukin-2 -- biosynthesis KW - Mice KW - Cell Membrane -- metabolism KW - Hydrolysis KW - Fluorescent Antibody Technique KW - Immunoassay KW - Antibodies, Monoclonal -- immunology KW - T-Lymphocytes -- physiology KW - Receptors, Antigen, T-Cell -- biosynthesis KW - Receptors, Antigen, T-Cell -- analysis KW - T-Lymphocytes -- immunology KW - Receptors, Antigen, T-Cell -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78116913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Failure+to+synthesize+the+T+cell+CD3-zeta+chain%3A+structure+and+function+of+a+partial+T+cell+receptor+complex.&rft.au=Sussman%2C+J+J%3BBonifacino%2C+J+S%3BLippincott-Schwartz%2C+J%3BWeissman%2C+A+M%3BSaito%2C+T%3BKlausner%2C+R+D%3BAshwell%2C+J+D&rft.aulast=Sussman&rft.aufirst=J&rft.date=1988-01-15&rft.volume=52&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Cell&rft.issn=00928674&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-14 N1 - Date created - 1988-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of metabolism and DNA adduct formation in the induction of sister chromatid exchanges in human lymphocytes by diethylstilbestrol. AN - 78039015; 3335009 AB - Recent studies have shown that diethylstilbestrol (DES) induces sister chromatid exchanges (SCEs) in lymphocytes from pregnant and premenopausal women but has only a slight effect on lymphocytes from post-menopausal women or men. In this study blood specimens from premenopausal women were used to define the role of different metabolic pathways on DES-induced formation of SCEs and to determine whether conditions resulting in induction of SCEs also induced detectable levels of DNA adducts. Exposure of lymphocytes in vitro to 0-40 microM DES induced a concentration-dependent increase in SCEs. Addition of indomethacin to the cultures partially abolished DES-induced SCEs, suggesting involvement of prostaglandin synthetases in the formation of specific DES metabolites that cause SCEs. alpha-Naphthoflavone, an inhibitor of cytochrome P-450 monooxygenases, had no effect on DES-induced SCEs. Cells exposed to DES at doses sufficient to cause large increases in SCE induction did not have adducts detectable by a 32P-postlabeling assay capable of revealing adducts at a level of 1 adduct/10(9) normal nucleotides. JF - Cancer research AU - Lundgren, K AU - Randerath, K AU - Everson, R B AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988/01/15/ PY - 1988 DA - 1988 Jan 15 SP - 335 EP - 338 VL - 48 IS - 2 SN - 0008-5472, 0008-5472 KW - Benzoflavones KW - 0 KW - alpha-naphthoflavone KW - 604-59-1 KW - Diethylstilbestrol KW - 731DCA35BT KW - DNA KW - 9007-49-2 KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Lymphocytes -- ultrastructure KW - Lymphocytes -- drug effects KW - Female KW - Indomethacin -- pharmacology KW - Benzoflavones -- pharmacology KW - Diethylstilbestrol -- metabolism KW - Diethylstilbestrol -- toxicity KW - DNA -- metabolism KW - Sister Chromatid Exchange -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78039015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Role+of+metabolism+and+DNA+adduct+formation+in+the+induction+of+sister+chromatid+exchanges+in+human+lymphocytes+by+diethylstilbestrol.&rft.au=Lundgren%2C+K%3BRanderath%2C+K%3BEverson%2C+R+B&rft.aulast=Lundgren&rft.aufirst=K&rft.date=1988-01-15&rft.volume=48&rft.issue=2&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Contrasting duration of inhibition of cell-cell communication in primary mouse epidermal cells by phorbol 12,13-dibutyrate and by bryostatin 1. AN - 78034214; 3422054 AB - The bryostatins, macrocyclic lactones isolated on the basis of their antineoplastic activity, activate protein kinase C in vitro and inhibit phorbol ester binding to the enzyme. In intact cells, the bryostatins induce some phorbol ester responses, such as neutrophil activation, but paradoxically they not only fail to induce other responses, e.g., differentiation in HL-60 promyelocytic leukemia cells, but actually block response to the phorbol esters. We compare here bryostatin I and phorbol 12,13-dibutyrate as inhibitors of cell-cell communication in cultured primary mouse epidermal cells. Like phorbol 12,13-dibutyrate, bryostatin I at nanomolar concentrations markedly inhibited cell coupling. It differed from the phorbol esters, however, in that its action was more transient. By 4 h of incubation bryostatin 1 caused little inhibition of coupling. Moreover, coincubation of bryostatin 1 and phorbol 12,13-dibutyrate gave no greater response at this time than that found for bryostatin 1 alone. Time-dependent inhibition of the protein kinase C pathway could account for many of the observed differences between the actions of the phorbol esters and bryostatin 1. JF - Cancer research AU - Pasti, G AU - Rivedal, E AU - Yuspa, S H AU - Herald, C L AU - Pettit, G R AU - Blumberg, P M AD - Molecular Mechanisms of Tumor Promotion Section, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988/01/15/ PY - 1988 DA - 1988 Jan 15 SP - 447 EP - 451 VL - 48 IS - 2 SN - 0008-5472, 0008-5472 KW - Bryostatins KW - 0 KW - Lactones KW - Macrolides KW - Phorbol Esters KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - bryostatin 1 KW - 37O2X55Y9E KW - Protein Kinase C KW - EC 2.7.11.13 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Skin -- drug effects KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Calcium -- physiology KW - Mice KW - Protein Kinase C -- physiology KW - Mice, Inbred BALB C KW - Time Factors KW - Phorbol Esters -- pharmacology KW - Cell Communication -- drug effects KW - Lactones -- metabolism KW - Lactones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78034214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Contrasting+duration+of+inhibition+of+cell-cell+communication+in+primary+mouse+epidermal+cells+by+phorbol+12%2C13-dibutyrate+and+by+bryostatin+1.&rft.au=Pasti%2C+G%3BRivedal%2C+E%3BYuspa%2C+S+H%3BHerald%2C+C+L%3BPettit%2C+G+R%3BBlumberg%2C+P+M&rft.aulast=Pasti&rft.aufirst=G&rft.date=1988-01-15&rft.volume=48&rft.issue=2&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Risk of second cancers after treatment for Hodgkin's disease. AN - 78079555; 3336397 AB - We estimated the risk of second cancers among 1507 patients with Hodgkin's disease treated at Stanford University Medical Center since 1968. Eight-three second cancers occurred more than one year after diagnosis, as compared with 15.9 expected on the basis of rates in the general population (relative risk, 5.2; 95 percent confidence interval, 4.2 to 6.5). The mean (+/- SE) 15-year actuarial risk of all second cancers was 17.6 +/- 3.1 percent, of which 13.2 +/- 3.1 percent was due to solid tumors. The risk of leukemia appeared to reach a plateau level of 3.3 +/- 0.6 percent at 10 years, whereas non-Hodgkin's lymphoma continued to increase, to 1.6 +/- 0.7 percent by the end of the follow-up period. The risk of solid tumors did not vary significantly according to treatment category, with the array of neoplasms resembling that previously observed in populations exposed to radiation and in immunosuppressed groups. The risk of leukemia, although elevated after radiation therapy alone (relative risk, 11; 95 percent confidence interval, 1.2 to 38), was much higher after either adjuvant chemotherapy (relative risk, 117; 95 percent confidence interval, 69 to 185) or chemotherapy alone (relative risk, 130; 95 percent confidence interval, 26 to 380). These data suggest that the risk of solid tumors after therapy for Hodgkin's disease continues to increase with time. JF - The New England journal of medicine AU - Tucker, M A AU - Coleman, C N AU - Cox, R S AU - Varghese, A AU - Rosenberg, S A AD - Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD. 20892. Y1 - 1988/01/14/ PY - 1988 DA - 1988 Jan 14 SP - 76 EP - 81 VL - 318 IS - 2 SN - 0028-4793, 0028-4793 KW - Antineoplastic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Leukemia -- chemically induced KW - Neoplasms, Radiation-Induced -- etiology KW - Humans KW - Leukemia, Radiation-Induced -- etiology KW - Aged KW - Child KW - Radiotherapy -- adverse effects KW - Antineoplastic Agents -- adverse effects KW - Child, Preschool KW - Risk Factors KW - Neoplasms -- chemically induced KW - Adult KW - Lymphoma, Non-Hodgkin -- etiology KW - Middle Aged KW - Adolescent KW - Female KW - Neoplasms, Multiple Primary KW - Hodgkin Disease -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78079555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Risk+of+second+cancers+after+treatment+for+Hodgkin%27s+disease.&rft.au=Tucker%2C+M+A%3BColeman%2C+C+N%3BCox%2C+R+S%3BVarghese%2C+A%3BRosenberg%2C+S+A&rft.aulast=Tucker&rft.aufirst=M&rft.date=1988-01-14&rft.volume=318&rft.issue=2&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-02 N1 - Date created - 1988-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modulation of neurotransmitter metabolism by dihydropyridine calcium channel ligands in mouse brain. AN - 78116026; 2449929 AB - The regional concentrations of dopamine, serotonin, dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindole acetic acid were measured in mouse brain following administration of the dihydropyridine calcium channel activator BAY K 8644, and antagonist, nifedipine. BAY K 8644 (1-8 mg/kg) produced dose- and time-dependent increases in dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindoleacetic acid concentrations in the caudate, without altering dopamine and serotonin levels. No changes in 5-hydroxyindoleacetic acid concentration were observed in the raphe nuclei, hypothalamus, hippocampus and frontal cortex. Nifedipine (4 mg/kg) blocked BAY K 8644- (2 mg/kg) elicited increases in dihydroxyphenylacetic acid in the caudate. Furthermore, a higher dose of nifedipine (8 mg/kg) decreased dihydroxyphenylacetic acid and homovanillic acid, but did not affect dopamine, serotonin or 5-hydroxyindoleacetic acid concentrations, while a lower dose of nifedipine (2 mg/kg) significantly increased serotonin, 5-hydroxyindoleacetic acid and homovanillic acid, but did not affect dopamine and dihydroxyphenylacetic acid concentrations. The findings that both BAY K 8644 and nifedipine affect neurotransmitter metabolism in vivo in a dose-, time- and brain region-dependent manner, suggest that high-affinity dihydropyridine calcium channel binding sites play an important role in regulating neurotransmitter turnover in the central nervous system. JF - Brain research AU - Bolger, G T AU - Lesieur, P AU - Basile, A S AU - Skolnick, P AD - Laboratory of Neuroscience, NIDDK, Bethesda, MD 20892. Y1 - 1988/01/12/ PY - 1988 DA - 1988 Jan 12 SP - 101 EP - 107 VL - 438 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Dihydropyridines KW - 0 KW - Ion Channels KW - Neurotransmitter Agents KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester KW - 71145-03-4 KW - Nifedipine KW - I9ZF7L6G2L KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Animals KW - Drug Interactions KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Hydroxyindoleacetic Acid -- metabolism KW - Dopamine -- metabolism KW - Mice KW - Homovanillic Acid -- metabolism KW - Male KW - Nifedipine -- pharmacology KW - Dihydropyridines -- pharmacology KW - Neurotransmitter Agents -- metabolism KW - 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester -- metabolism KW - Brain -- drug effects KW - Ion Channels -- drug effects KW - 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester -- pharmacology KW - Dihydropyridines -- metabolism KW - Nifedipine -- metabolism KW - Brain -- metabolism KW - Ion Channels -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78116026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Modulation+of+neurotransmitter+metabolism+by+dihydropyridine+calcium+channel+ligands+in+mouse+brain.&rft.au=Bolger%2C+G+T%3BLesieur%2C+P%3BBasile%2C+A+S%3BSkolnick%2C+P&rft.aulast=Bolger&rft.aufirst=G&rft.date=1988-01-12&rft.volume=438&rft.issue=1-2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-18 N1 - Date created - 1988-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Monoclonal antibodies against type II rat brain protein kinase C. AN - 78047469; 3422075 AB - Monoclonal antibodies (8/1, 10/10, and 25/3) against rat brain type II protein kinase C were used for the immunochemical characterization of this kinase. These antibodies immunoprecipitated the type II protein kinase C in a dose-dependent manner but did neither to the type I nor III isozyme. Immunoblot analysis of the tryptic fragments from protein kinase C revealed that all three antibodies recognized the 27-38-kDa fragments, the phospholipid/phorbol ester-binding domain, but not the 45-48-kDa fragments, the kinase catalytic domain. The immune complexes of the kinase and the antibodies retained 70-80% of the kinase activity which was dependent on Ca2+ and phosphatidylserine and further activated by diacylglycerol or tumor-promoting phorbol ester. With antibody 8/1, the kinetic parameters with respect to Km for ATP and histone and K alpha for phosphatidylserine and phorbol 12,13-dibutyrate were not significantly influenced. However, the antibody causes variable effects on the K alpha for Ca2+ under different assay conditions. When determined in the presence of phosphatidylserine, the K alpha for Ca2+ was reduced by an order of magnitude (37 +/- 8 to 2.0 +/- 1.8 microM); in the presence of phosphatidylserine and phorbol 12,13-dibutyrate, the K alpha for Ca2+ was not significantly altered; and in the presence of phosphatidylserine and dioleoylglycerol, the kinase became an apparently Ca2+-independent enzyme. The effects of antibody 8/1 on the kinetic parameters of the enzyme for phorbol ester binding were different from those for kinase activity. This antibody causes a 20-30% reduction in phorbol ester binding and a 2-fold increase (1.9 +/- 0.2 to 3.9 +/- 0.3 micrograms/ml) in the concentration of phosphatidylserine required for half-maximal binding, but is without significant influence on those parameters for Ca2+ and phorbol 12,13-dibutyrate. The differential effects of antibody 8/1 on kinase activity and phorbol ester binding with respect to the kinetic parameter of phosphatidylserine suggest that the roles of this phospholipid in supporting phorbol ester binding and kinase activation are different. In the presence of the antibody, the autophosphorylations of the phospholipid/phorbol ester-binding domain and the kinase domain were reduced; the reduction was more pronounced for the former than for the latter. These results suggest that the epitope for antibody 8/1 is localized within the phospholipid/phorbol ester-binding domain at the region adjacent to the kinase domain so that the autophosphorylations of both domains are affected. JF - The Journal of biological chemistry AU - Nakabayashi, H AU - Huang, K P AD - Section on Metabolic Regulation, National Institute of Child Health and Human Development, Bethesda, Maryland 20892. Y1 - 1988/01/05/ PY - 1988 DA - 1988 Jan 05 SP - 298 EP - 304 VL - 263 IS - 1 SN - 0021-9258, 0021-9258 KW - Antibodies, Monoclonal KW - 0 KW - Antigen-Antibody Complex KW - Carcinogens KW - Isoenzymes KW - Peptide Fragments KW - Phorbol Esters KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats KW - Phorbol Esters -- pharmacology KW - Carcinogens -- pharmacology KW - Animals KW - Phosphorylation KW - Kinetics KW - Peptide Fragments -- analysis KW - Calcium -- pharmacology KW - Protein Kinase C -- analysis KW - Isoenzymes -- analysis KW - Brain -- enzymology KW - Isoenzymes -- immunology KW - Protein Kinase C -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78047469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Monoclonal+antibodies+against+type+II+rat+brain+protein+kinase+C.&rft.au=Nakabayashi%2C+H%3BHuang%2C+K+P&rft.aulast=Nakabayashi&rft.aufirst=H&rft.date=1988-01-05&rft.volume=263&rft.issue=1&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-17 N1 - Date created - 1988-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs. AN - 78029291; 2826444 AB - Eighteen site-selective cAMP analogs modified at either the C-8 position or the C-6 position were tested for their growth regulatory effects on the Harvey murine sarcoma virus-transformed NIH/3T3 clone 13-3B-4 cells grown in a serum-free defined medium. All 18 analogs, when tested individually, exhibited an appreciable growth inhibitory effect at micromolar concentrations. The most potent growth inhibitory analogs contained a thio moiety at the C-8 position. In general, C-6 analogs required 5-10-fold greater concentrations than C-8 analogs to produce the same degree of growth inhibition. The growth inhibition induced by these analogs was accompanied by a change in cell morphology; cells treated with the analogs exhibited the morphology characteristic of untransformed fibroblasts, while untreated cells retained a transformed phenotype. The regulatory subunit of cAMP-dependent protein kinase, the cAMP receptor protein, has two different intrachain cAMP binding sites, and cAMP analogs modified at the C-8 position (C-8 analogs) are generally selective for Site 1, while analogs modified at the C-6 position (C-6 analogs) are generally selective for Site 2. Thus, C-8 and C-6 analogs were tested in combination to enhance the growth regulatory effect. Both growth inhibition and morphological change were enhanced synergistically by a combination of the C-6 and C-8 analogs. Two C-6 analogs or two C-8 analogs added together did not cause synergism. For both growth inhibition and phenotypic change, C-8 thio analogs acted far more synergistically than C-8 amino analogs when cells were treated in combination with C-6 analogs, suggesting a response of the RII rather than the RI cAMP receptor protein. DEAE-cellulose chromatography revealed that the growth inhibition, in fact, correlates with an increase of the RII cAMP receptor protein and a decrease of the RI receptor protein. The growth inhibitory effect of the site-selective analogs was not due to the cytotoxic effect of adenosine metabolites as shown by the different behavior of 8-Cl-cAMP compared with 8-Cl-adenosine in 1) cell cycle effects and 2) release from growth inhibition. It is concluded that the observed growth inhibition and phenotypic reversion of 13-3B-4 cells is most likely mediated through the cellular effector, the RII cAMP receptor protein. JF - The Journal of biological chemistry AU - Tagliaferri, P AU - Katsaros, D AU - Clair, T AU - Neckers, L AU - Robins, R K AU - Cho-Chung, Y S AD - Cellular Biochemistry Section, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988/01/05/ PY - 1988 DA - 1988 Jan 05 SP - 409 EP - 416 VL - 263 IS - 1 SN - 0021-9258, 0021-9258 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Cells, Cultured KW - Kinetics KW - Mice KW - Drug Synergism KW - Structure-Activity Relationship KW - Cyclic AMP -- pharmacology KW - Cyclic AMP -- analogs & derivatives KW - Harvey murine sarcoma virus -- genetics KW - Cell Transformation, Neoplastic -- drug effects KW - Sarcoma Viruses, Murine -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78029291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Reverse+transformation+of+Harvey+murine+sarcoma+virus-transformed+NIH%2F3T3+cells+by+site-selective+cyclic+AMP+analogs.&rft.au=Tagliaferri%2C+P%3BKatsaros%2C+D%3BClair%2C+T%3BNeckers%2C+L%3BRobins%2C+R+K%3BCho-Chung%2C+Y+S&rft.aulast=Tagliaferri&rft.aufirst=P&rft.date=1988-01-05&rft.volume=263&rft.issue=1&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-17 N1 - Date created - 1988-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neuropsychiatric consequences of AIDS. AN - 85281074; pmid-3348597 AB - As part of a study in progress, neuropsychological tests have been administered to 13 patients with clinical acquired immunodeficiency syndrome, 9 human immunodeficiency virus-seropositive patients, 4 seropositive patients with chronic active hepatitis, 5 seronegative patients with chronic active hepatitis, and 6 healthy controls. Consistent with findings in earlier patient and control groups, the acquired immunodeficiency syndrome patients had substantially lower scores on a variety of cognitive tests. Although the acquired immunodeficiency syndrome group is not education-matched at present, the results are nonetheless consistent with impairments of language function and timed, self-paced performance. Test results obtained may reflect focal and global cognitive impairment as well as motivational decrements in patients with the acquired immunodeficiency syndrome relative to seropositive patients or controls. JF - Annals of Neurology AU - Rubinow, D R AU - Berrettini, C H AU - Brouwers, P AU - Lane, H C AD - Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892. PY - 1988 SP - S24 EP - S26 VL - 23 Suppl SN - 0364-5134, 0364-5134 KW - Analysis of Variance KW - Reference Values KW - HIV Seropositivity KW - Mental Disorders KW - Human KW - Acquired Immunodeficiency Syndrome KW - Brain Diseases KW - Neuropsychological Tests KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85281074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Neurology&rft.atitle=Neuropsychiatric+consequences+of+AIDS.&rft.au=Rubinow%2C+D+R%3BBerrettini%2C+C+H%3BBrouwers%2C+P%3BLane%2C+H+C&rft.aulast=Rubinow&rft.aufirst=D&rft.date=1988-01-01&rft.volume=23+Suppl&rft.issue=&rft.spage=S24&rft.isbn=&rft.btitle=&rft.title=Annals+of+Neurology&rft.issn=03645134&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The relationship between genetic deafness and fear-related behaviors in nervous pointer dogs. AN - 85261966; pmid-3174842 AB - Nervous pointer dogs have been extensively characterized as an animal model for some human pathological anxiety states. During our work with these animals suspicion developed that some of these dogs had a hearing deficit. We decided to systematically evaluate this observation and to study the relation between hearing status and fear-related behaviors in the nervous pointer dogs. Our results revealed that a majority of the nervous dogs in our colony (75%) suffer from bilateral deafness as demonstrated by complete absence of brain stem auditory evoked response. Furthermore, behavioral ratings revealed that hearing and deaf dogs do not differ in their pathological response to the characteristic fear-provoking stimuli (e.g., human interaction) and that both hearing and deaf nervous dogs markedly differ from normal dogs in that respect. The relation between these abnormalities and their implications for research involving breeding of animals for selected traits are further discussed in this report. JF - Physiology & Behavior AU - Klein, E AU - Steinberg, S A AU - Weiss, S R AU - Matthews, D M AU - Uhde, T W AD - Unit on Anxiety and Affective Disorders, NIMH, Bethesda, MD 20892. PY - 1988 SP - 307 EP - 312 VL - 43 IS - 3 SN - 0031-9384, 0031-9384 KW - Dog Diseases KW - Arousal KW - Fear KW - Animal KW - Disease Models, Animal KW - Behavior, Animal KW - Deafness KW - Brain Stem KW - Dogs KW - Evoked Potentials, Auditory KW - Support, Non-U.S. Gov't KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85261966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiology+%26+Behavior&rft.atitle=The+relationship+between+genetic+deafness+and+fear-related+behaviors+in+nervous+pointer+dogs.&rft.au=Klein%2C+E%3BSteinberg%2C+S+A%3BWeiss%2C+S+R%3BMatthews%2C+D+M%3BUhde%2C+T+W&rft.aulast=Klein&rft.aufirst=E&rft.date=1988-01-01&rft.volume=43&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Physiology+%26+Behavior&rft.issn=00319384&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The National Toxicology Program chemical nomination selection and testing process. AN - 78821065; 2980357 AB - The NTP is an interagency program of the Federal Government which coordinates toxicological programs at the NIH (NIEHS), FDA (NCTR), and CDC (NIOSH) with input from NCI, NIH, OSHA, CPSC, EPA, and ATSDR. The NTP has the capability to completely characterize the toxicologic profile of a chemical, including studies of chemical disposition, genetic toxicity, immunotoxicity, teratology, reproductive toxicity, carcinogenicity, neurotoxicity, and specific organ toxicity. The NTP encourages nominations of chemicals of human health concern from all sectors of the public, including industry, labor, and the general public. The specific process of nomination, evaluation, and selection of chemicals for testing by the NTP is described. It is a multicomponent system with several evaluations and a public peer review step to assure adequate consideration of all nominated chemicals. The results of NTP studies are all peer reviewed and available to the general public as well as to the scientific community. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Heindel, J J AD - National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 273 EP - 279 VL - 2 IS - 3-4 SN - 0890-6238, 0890-6238 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - United States KW - Animals KW - Reproduction -- drug effects KW - Hazardous Substances -- toxicity KW - Government Agencies -- organization & administration KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78821065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=The+National+Toxicology+Program+chemical+nomination+selection+and+testing+process.&rft.au=Heindel%2C+J+J&rft.aulast=Heindel&rft.aufirst=J&rft.date=1988-01-01&rft.volume=2&rft.issue=3-4&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-07 N1 - Date created - 1992-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The relationship between ethanol intake and DSM-III alcohol use disorders: a cross-perspective analysis. AN - 78817942; 2980873 AB - The purpose of this investigation was to quantify the relationship between ethanol consumption and DSM-III alcohol use disorders using mathematical modeling techniques that allowed for the simultaneous control of several extraneous factors and the assessment of potential interaction. Although gender, education, ethnicity, and marital status were not identified as actual confounders in the logistic regression model, the ethanol intake-dependence association was found to be stronger among younger adults than in the later stages of life. Age was an influential confounder of the ethanol intake-abuse relationship, but the magnitude of the association was generally weaker for abuse than for dependence. Separate analyses in which the abuse and dependence criteria served as outcome measures qualified the interpretation of the overall ethanol intake-disorder associations. Implications of these results are discussed in terms of age differences in exposure and context of consumption, differential interpretation of withdrawal symptoms, and the relationship between abuse and dependence. The need for future research to refine our descriptions of risk of alcohol use disorders in relation to levels of intake is highlighted. JF - Journal of substance abuse AU - Grant, B F AU - Harford, T C AD - National Institute on Alcohol Abuse and Alcoholism, Division of Biometry and Epidemiology, Rockville, MD 20857. PY - 1988 SP - 231 EP - 252 VL - 1 IS - 2 SN - 0899-3289, 0899-3289 KW - Index Medicus KW - Age Factors KW - Risk Factors KW - Humans KW - Adult KW - Middle Aged KW - Adolescent KW - Psychometrics KW - Male KW - Female KW - Alcoholism -- diagnosis KW - Alcoholism -- classification KW - Alcohol Drinking -- psychology KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78817942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse&rft.atitle=The+relationship+between+ethanol+intake+and+DSM-III+alcohol+use+disorders%3A+a+cross-perspective+analysis.&rft.au=Grant%2C+B+F%3BHarford%2C+T+C&rft.aulast=Grant&rft.aufirst=B&rft.date=1988-01-01&rft.volume=1&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse&rft.issn=08993289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-23 N1 - Date created - 1992-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The nephropathy of systemic lupus erythematosus. AN - 78807918; 2979809 AB - Lupus nephritis may be considered the prototypic autoimmune disease which is initiated by immune complex deposition. Several patterns of localization of immunoreactants are observed in lupus nephritis, but few data are available to elucidate the corresponding immunopathogenetic mechanisms. Corticosteroids form the mainstay of therapy for lupus nephritis, provided that they achieve a prompt clinical remission which can be sustained with alternate day therapy. Cyclophosphamide may have fewer risks than extended high-dose prednisone and it has been shown to be more efficacious than corticosteroids in preventing end stage renal failure. JF - In vivo (Athens, Greece) AU - Balow, J E AD - Kidney Disease Section, National Institutes of Health, Bethesda, Maryland 20892. PY - 1988 SP - 111 EP - 114 VL - 2 IS - 1 SN - 0258-851X, 0258-851X KW - Immunosuppressive Agents KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - Azathioprine KW - MRK240IY2L KW - Index Medicus KW - Cyclophosphamide -- therapeutic use KW - Humans KW - Azathioprine -- therapeutic use KW - Lupus Nephritis -- drug therapy KW - Lupus Nephritis -- immunology KW - Immunosuppressive Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78807918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vivo+%28Athens%2C+Greece%29&rft.atitle=The+nephropathy+of+systemic+lupus+erythematosus.&rft.au=Balow%2C+J+E&rft.aulast=Balow&rft.aufirst=J&rft.date=1988-01-01&rft.volume=2&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=In+vivo+%28Athens%2C+Greece%29&rft.issn=0258851X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-03-09 N1 - Date created - 1992-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Using time-to-pregnancy data to study occupational exposures: methodology. AN - 78807052; 2980347 AB - Occupational and environmental influences on fertility are for the most part unstudied, partly because sensitive methods for studying them have not been developed. We are developing a measure of fecundability, the monthly probability of pregnancy, by studying time to pregnancy, the number of noncontracepting menstrual cycles each couple requires to conceive. The relationship of this measure of reproductive impairment with others, such as spontaneous abortion, is not known. Preliminary data from two sources suggest that reduced fertility is not highly correlated with increased risk of spontaneous abortion, despite predictions to the contrary from the toxicology literature. A current study of occupational exposures of dental assistants will address questions of data quality by providing comparisons of brief responses from mail questionnaires and telephone interviews with very detailed data from telephone interviews. This study also will allow estimation of the magnitude of two potential selection biases: selection of only planned pregnancies (time-to-pregnancy data for accidental pregnancies are not meaningful), and selection against highly infertile and sterile couples (when studying currently or previously pregnant women, sterile couples are not represented at all and highly infertile couples are underrepresented). JF - Reproductive toxicology (Elmsford, N.Y.) AU - Baird, D D AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 205 EP - 207 VL - 2 IS - 3-4 SN - 0890-6238, 0890-6238 KW - Index Medicus KW - Humans KW - Time Factors KW - Female KW - Occupational Exposure KW - Pregnancy -- statistics & numerical data KW - Fertility -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78807052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Using+time-to-pregnancy+data+to+study+occupational+exposures%3A+methodology.&rft.au=Baird%2C+D+D&rft.aulast=Baird&rft.aufirst=D&rft.date=1988-01-01&rft.volume=2&rft.issue=3-4&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-07 N1 - Date created - 1992-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Teratogenicity of benzoic acid derivatives of retinoic acid in cultured mouse embryos. AN - 78806842; 2980411 AB - Isotretinoin (13-cis-RA) is a human teratogen and mouse embryos exposed to 13-cis-RA in vivo exhibit many of the same defects as humans. Early postimplantation mouse embryos exposed to 13-cis-RA in culture exhibit developmental alterations of the visceral arches, similar to those seen after in vivo exposure. Certain benzoic acid derivatives of retinoic acid have been shown to possess activity equal to or greater than retinoic acid in several in vitro systems. This study examines the teratogenic effects of some of these retinoids on mouse embryos in vitro. Day 8 CD-1 mouse embryos were cultured for 48 hours in the presence of these benzoic acid derivatives. With the exception of Ro-15-0778, all compounds produced visceral arch malformations similar to those seen in embryos exposed to 13-cis-RA, but at dramatically different effective concentrations. Extremely low concentrations of the retinoic acid-related compounds tested appear to have detrimental effects on embryonic development and these compounds may be poor candidates for therapeutic use. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Goulding, E H AU - Jetten, A M AU - Abbott, B D AU - Pratt, R M AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 91 EP - 98 VL - 2 IS - 2 SN - 0890-6238, 0890-6238 KW - Benzoates KW - 0 KW - Teratogens KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Molecular Structure KW - Animals KW - Culture Techniques KW - Mice -- embryology KW - Male KW - Female KW - Structure-Activity Relationship KW - Tretinoin -- analogs & derivatives KW - Tretinoin -- toxicity KW - Teratogens -- toxicity KW - Embryo, Mammalian -- drug effects KW - Benzoates -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78806842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Teratogenicity+of+benzoic+acid+derivatives+of+retinoic+acid+in+cultured+mouse+embryos.&rft.au=Goulding%2C+E+H%3BJetten%2C+A+M%3BAbbott%2C+B+D%3BPratt%2C+R+M&rft.aulast=Goulding&rft.aufirst=E&rft.date=1988-01-01&rft.volume=2&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-12 N1 - Date created - 1992-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunologic effects of drugs of abuse. AN - 78803177; 3151938 JF - NIDA research monograph AU - Weber, R AD - Section on Drug Design and Synthesis, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 99 EP - 104 VL - 90 SN - 1046-9516, 1046-9516 KW - Immunosuppressive Agents KW - 0 KW - Narcotics KW - Street Drugs KW - Index Medicus KW - Animals KW - Humans KW - Narcotics -- pharmacology KW - Immune System -- drug effects KW - Street Drugs -- pharmacology KW - Substance-Related Disorders -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78803177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Immunologic+effects+of+drugs+of+abuse.&rft.au=Weber%2C+R&rft.aulast=Weber&rft.aufirst=R&rft.date=1988-01-01&rft.volume=90&rft.issue=&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-05 N1 - Date created - 1989-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - AIDS and intravenous drug abuse. AN - 78802339; 3151917 JF - NIDA research monograph AU - Schuster, C AU - Pickens, R AD - National Institute on Drug Abuse, Rockville, MD 20857. Y1 - 1988 PY - 1988 DA - 1988 SP - 1 EP - 13 VL - 90 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - AIDS/HIV KW - United States Public Health Service KW - Humans KW - Adult KW - Child KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Acquired Immunodeficiency Syndrome -- epidemiology KW - Acquired Immunodeficiency Syndrome -- transmission KW - Substance Abuse, Intravenous -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78802339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=AIDS+and+intravenous+drug+abuse.&rft.au=Schuster%2C+C%3BPickens%2C+R&rft.aulast=Schuster&rft.aufirst=C&rft.date=1988-01-01&rft.volume=90&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-05 N1 - Date created - 1989-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - TGF alpha stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression. AN - 78790194; 2475136 AB - To investigate the role of transforming growth factor alpha (TGF alpha) in tumor development, we introduced the human TGF alpha (hTGF alpha) cDNA into cultured primary mouse epidermal cells or papilloma cells using a replication-defective retroviral vector and analyzed skin grafts constructed with such cells. Expression of the exogenous gene was confirmed by detection of hTGF alpha mRNA by northern RNA blot analysis, and the secreted hTGF alpha was measured by ELISA of culture supernatants. Tumor cells expressing hTGF alpha produced benign tumors (papillomas), which were 1.5- to 2-fold larger than tumors of parental cells when tested as skin grafts on nude mice. Grafts of normal cells that expressed hTGF alpha produced normal skin. When mixtures of parental tumor cells and normal mouse keratinocytes were grafted to nude mice, papilloma formation was suppressed and tumors that did form were small. Grafts of hTGF alpha-producing papilloma cells combined with either normal epidermal cells or hTGF alpha-producing epidermal cells yielded large tumors. Mixed grafts containing keratinocytes expressing hTGF alpha and parental papilloma cells also produced large tumors. While the tumor size was substantially increased by hTGF alpha expression, the tumors that developed in all groups were histologically benign and reached a stable size 4-5 wk after grafting. These results indicate that expression of hTGF alpha by either tumor cells (autocrine) or adjoining normal cells (paracrine) can stimulate tumor growth, particularly when tumor growth is suppressed by normal tissue. However, expression of this growth factor did not appear to influence tumor progression directly. JF - Molecular carcinogenesis AU - Finzi, E AU - Kilkenny, A AU - Strickland, J E AU - Balaschak, M AU - Bringman, T AU - Derynck, R AU - Aaronson, S AU - Yuspa, S H AD - Laboratories of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 7 EP - 12 VL - 1 IS - 1 SN - 0899-1987, 0899-1987 KW - RNA, Messenger KW - 0 KW - Keratins KW - 68238-35-7 KW - Transforming Growth Factors KW - 76057-06-2 KW - Index Medicus KW - Keratins -- genetics KW - Animals KW - Blotting, Northern KW - Skin -- metabolism KW - Disease Models, Animal KW - Mice KW - Mice, Nude KW - RNA, Messenger -- genetics KW - Keratins -- biosynthesis KW - Neoplasm Transplantation KW - Transfection KW - Blotting, Southern KW - Cell Line KW - Skin Neoplasms -- genetics KW - Papilloma -- pathology KW - Skin Neoplasms -- pathology KW - Papilloma -- genetics KW - Transforming Growth Factors -- physiology KW - Transforming Growth Factors -- biosynthesis KW - Transforming Growth Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78790194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=TGF+alpha+stimulates+growth+of+skin+papillomas+by+autocrine+and+paracrine+mechanisms+but+does+not+cause+neoplastic+progression.&rft.au=Finzi%2C+E%3BKilkenny%2C+A%3BStrickland%2C+J+E%3BBalaschak%2C+M%3BBringman%2C+T%3BDerynck%2C+R%3BAaronson%2C+S%3BYuspa%2C+S+H&rft.aulast=Finzi&rft.aufirst=E&rft.date=1988-01-01&rft.volume=1&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-28 N1 - Date created - 1989-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Thymic T-cell lymphoma with the CD8+ (OX-8), CD4+ (W3/25) phenotype, induced in F344/NCr rats by nitroso-2-hydroxypropylurea. AN - 78787624; 3267160 AB - Thymic T-cell lymphomas were induced by administration of nitroso-2-hydroxypropylurea (NHPU) at a dose of 1.6 mg by gavage twice weekly for each of 20 weeks in F344/NCr rats. Lymphomas began to appear 5-10 weeks after the first intubation. Primary and transplantable tumors were subjected to morphological, histogenetic and immunological characterization. Lymphomas composed of medium-sized lymphocytes (prolymphocytes) arose within individual thymic lobules, often in atrophic thymic lobes and metastasized slowly to the T-cell zones of the splenic white pulp. The tissue fixative was important for tumor morphology and classification, with Bouin's fluid markedly superior to formalin. Transplantable tumors were similar morphologically except for one lymphoblastic lymphoma, but all transplants metastasized quickly to spleen, liver, thymus, and other tissues. Fluorescence-activated cell sorter (FACS) analysis of primary and transplantable lymphomas revealed cells of the T-cell lineage, with tumor cells expressing both OX-8 (CD8) and W3/25 (CD4) antigens. Immunoperoxidase studies of spleen showed infiltration of OX-8+ tumor cells first into T-cell dependent areas of the splenic white pulp. JF - Thymus AU - Konishi, N AU - Ward, J M AU - Reynolds, C W AU - Lijinsky, W AD - Tumor Pathology and Pathogenesis Section, Division of Cancer Etiology, National Cancer Institute, Frederick, MD 21701. PY - 1988 SP - 225 EP - 237 VL - 12 IS - 4 SN - 0165-6090, 0165-6090 KW - Nitroso Compounds KW - 0 KW - Index Medicus KW - Rats KW - Phenotype KW - Neoplasm Transplantation KW - Animals KW - Rats, Inbred F344 KW - Male KW - Lymphoma -- genetics KW - Thymus Neoplasms -- genetics KW - Thymus Neoplasms -- chemically induced KW - Lymphoma -- chemically induced KW - Nitroso Compounds -- toxicity KW - Lymphoma -- pathology KW - Thymus Neoplasms -- pathology KW - T-Lymphocytes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78787624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thymus&rft.atitle=Thymic+T-cell+lymphoma+with+the+CD8%2B+%28OX-8%29%2C+CD4%2B+%28W3%2F25%29+phenotype%2C+induced+in+F344%2FNCr+rats+by+nitroso-2-hydroxypropylurea.&rft.au=Konishi%2C+N%3BWard%2C+J+M%3BReynolds%2C+C+W%3BLijinsky%2C+W&rft.aulast=Konishi&rft.aufirst=N&rft.date=1988-01-01&rft.volume=12&rft.issue=4&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Thymus&rft.issn=01656090&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-12 N1 - Date created - 1989-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of P+-active and -inactive pro-1 homologues from human nasopharyngeal carcinoma cells. AN - 78785641; 3255389 AB - Eleven pro-1 homologous clones from human nasopharyngeal carcinoma cell line CNE2 were studied with respect to their ability to transfer sensitivity to tumor promoter-induced neoplastic transformation (P+ activity), their molecular structure, and their homology to both mouse pro-1 and each other. Restriction mapping and Southern analysis of CNE2 pro-1 homologous clones revealed three structural classes, all of which showed P+ activity. The approximate limits of mouse pro-1 hybridizing sequences within CNE2 clones from each structural class were identified, and some of these minimum homologous sequences were tested for P+ activity by transfection into P- cells. For all classes, a strong association between P+ activity and pro-1 homology was observed. This finding implies that, for CNE2 clones to be P+-active, structural homology to mouse pro-1 is required. The minimum P+-active sequence thus far identified was a 2.6-kbp EcoRI-SstI fragment. One clone was inactive, even though it was indistinguishable from active clones of the same class by restriction mapping, Southern analysis, and electron microscope examination of heteroduplexes formed by an active and an inactive clone. This raises the possibility that discrete changes, involving a few nucleotides rather than gross rearrangement, may determine the P+ activation of these pro-1-homologous sequences. JF - Molecular carcinogenesis AU - Dowjat, W K AU - Ya, C AU - Nagashima, K AU - Sakai, A AU - Colburn, N H AD - Cell Biology Section, Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701. Y1 - 1988 PY - 1988 DA - 1988 SP - 33 EP - 40 VL - 1 IS - 1 SN - 0899-1987, 0899-1987 KW - DNA, Neoplasm KW - 0 KW - Nucleic Acid Heteroduplexes KW - Index Medicus KW - DNA, Neoplasm -- ultrastructure KW - Clone Cells KW - Sequence Homology, Nucleic Acid KW - Blotting, Southern KW - Nucleic Acid Heteroduplexes -- ultrastructure KW - Humans KW - Restriction Mapping KW - DNA, Neoplasm -- genetics KW - Mutation KW - Cell Line KW - Structure-Activity Relationship KW - Cloning, Molecular KW - Gene Expression Regulation KW - Nasopharyngeal Neoplasms -- genetics KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78785641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Comparison+of+P%2B-active+and+-inactive+pro-1+homologues+from+human+nasopharyngeal+carcinoma+cells.&rft.au=Dowjat%2C+W+K%3BYa%2C+C%3BNagashima%2C+K%3BSakai%2C+A%3BColburn%2C+N+H&rft.aulast=Dowjat&rft.aufirst=W&rft.date=1988-01-01&rft.volume=1&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-28 N1 - Date created - 1989-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Malignant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene. AN - 78784545; 2475137 AB - Murine papilloma cell lines 308 and SP-1 have been used as recipients for transfected oncogenes to investigate malignant conversion. These cell lines express an activated c-rasHa gene with a codon 61 mutation and produce squamous papillomas when transplanted as skin grafts onto nude mice. They are not tumorigenic by subcutaneous injection. Both papilloma cell lines were stably transfected with plasmid DNA containing either a rearranged murine plasmacytoma-derived c-myc (minus exon 1), adenovirus 5 E1A, FBJ v-fos or a human c-fos/FBJ v-fos chimera, using cotransfection with the neomycin resistance gene contained in pSV2neo to select for transformants. Southern and northern blotting analysis confirmed the uptake and expression of exogenous DNA in both G418-selected cell lines and in the derived tumors. Unlike the E1A- and myc-containing plasmids, both fos constructs caused malignant conversion in either cell line, as defined by the squamous cell carcinoma histology of tumors from grafted cells and the development of carcinomas after subcutaneous injection into athymic nude mice. Immunofluorescence analysis for specific keratin gene expression indicated that tumors derived by introduction of either of the fos oncogenes were devoid of staining for K1, a 67 kDa epidermal keratin that is expressed in papillomas but not in squamous carcinomas. Tumors from E1A, myc, or pSV2neo transfectants expressed K1, although in a focal distribution. The malignant phenotype induced by the fos oncogene constructs was not associated with the ability to form agar colonies in vitro or to express gamma-glutamyl transpeptidase in the tumors. Since both 308 and SP-1 were sensitive to the fos oncogene for malignant conversion and insensitive to E1A or myc, it is possible that fos may cooperate with the endogenous-activated c-rasHa gene to convert these cells to malignancy. However, since gamma-glutamyl transpeptidase activity is found in the majority of chemically induced mouse skin carcinomas that possess an activated c-rasHa gene, fos activation may not be a common pathway for spontaneous malignant conversion. JF - Molecular carcinogenesis AU - Greenhalgh, D A AU - Yuspa, S H AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 134 EP - 143 VL - 1 IS - 2 SN - 0899-1987, 0899-1987 KW - Biomarkers, Tumor KW - 0 KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins c-fos KW - Keratins KW - 68238-35-7 KW - gamma-Glutamyltransferase KW - EC 2.3.2.2 KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - Index Medicus KW - Animals KW - Biomarkers, Tumor -- genetics KW - Immunoblotting KW - Papilloma -- pathology KW - gamma-Glutamyltransferase -- metabolism KW - Mice KW - Plasmids KW - Mice, Inbred BALB C KW - Papilloma -- genetics KW - Keratins -- biosynthesis KW - Neoplasm Transplantation KW - Proto-Oncogene Proteins -- genetics KW - Fluorescent Antibody Technique KW - Cell Line KW - Female KW - Cell Division KW - Oncogenes KW - Transfection KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78784545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Malignant+conversion+of+murine+squamous+papilloma+cell+lines+by+transfection+with+the+fos+oncogene.&rft.au=Greenhalgh%2C+D+A%3BYuspa%2C+S+H&rft.aulast=Greenhalgh&rft.aufirst=D&rft.date=1988-01-01&rft.volume=1&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-29 N1 - Date created - 1989-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - raf family serine/threonine protein kinases in mitogen signal transduction. AN - 78779121; 2978288 JF - Cold Spring Harbor symposia on quantitative biology AU - Rapp, U R AU - Heidecker, G AU - Huleihel, M AU - Cleveland, J L AU - Choi, W C AU - Pawson, T AU - Ihle, J N AU - Anderson, W B AD - Laboratory of Viral Carcinogenesis, National Cancer Institute-Frederick Cancer Research Facility, Maryland 21701. Y1 - 1988 PY - 1988 DA - 1988 SP - 173 EP - 184 VL - 53 Pt 1 SN - 0091-7451, 0091-7451 KW - Platelet-Derived Growth Factor KW - 0 KW - Proto-Oncogene Proteins KW - Protein Kinases KW - EC 2.7.- KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Proto-Oncogene Proteins c-raf KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Cells, Cultured KW - Humans KW - Genetic Vectors KW - Molecular Sequence Data KW - Mice KW - Amino Acid Sequence KW - Oncogenes -- drug effects KW - Signal Transduction -- drug effects KW - Platelet-Derived Growth Factor -- pharmacology KW - Protein Kinases -- genetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Proto-Oncogene Proteins -- genetics KW - Proto-Oncogenes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78779121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cold+Spring+Harbor+symposia+on+quantitative+biology&rft.atitle=raf+family+serine%2Fthreonine+protein+kinases+in+mitogen+signal+transduction.&rft.au=Rapp%2C+U+R%3BHeidecker%2C+G%3BHuleihel%2C+M%3BCleveland%2C+J+L%3BChoi%2C+W+C%3BPawson%2C+T%3BIhle%2C+J+N%3BAnderson%2C+W+B&rft.aulast=Rapp&rft.aufirst=U&rft.date=1988-01-01&rft.volume=53+Pt+1&rft.issue=&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Cold+Spring+Harbor+symposia+on+quantitative+biology&rft.issn=00917451&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-15 N1 - Date created - 1989-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Signal transduction for proliferation and differentiation in keratinocytes. AN - 78764011; 2470295 AB - In mouse and human epidermis, the Ca2+ environment of the basal cell layer is substantially below serum Ca2+, while that of the granular cell layer is unusually high. Reduction of extracellular Ca2+ concentration (Cao) in the medium of keratinocyte cultures maintains a basal cell phenotype while serum Ca2+ concentrations induce terminal differentiation. Measurements of intracellular Ca2+ (Cai) by the use of Fura 2 and digital imaging technology reveal that Cai increases 10-20-fold in response to an increase in Cao and remains elevated. Concomitant with the rise in Cai is an increase in the metabolism of phosphatidylinositol (PI) to yield inositol phosphates and diacylglycerol. PI metabolism is also stimulated by calcium ionophores suggesting that a rise in Cai is directly responsible. The consequent increase in diacylglycerol and Cai would activate protein kinase C, an event known to trigger epidermal differentiation. Specific Cao and Cai determine the expression of individual markers of keratinocyte differentiation in vitro. These findings may account for the importance of the Ca2+ gradient for maintaining regulated growth and differentiation of the epidermis in vivo. JF - Annals of the New York Academy of Sciences AU - Yuspa, S H AU - Hennings, H AU - Tucker, R W AU - Jaken, S AU - Kilkenny, A E AU - Roop, D R AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 191 EP - 196 VL - 548 SN - 0077-8923, 0077-8923 KW - Antigens, Differentiation KW - 0 KW - Keratins KW - 68238-35-7 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Humans KW - Antigens, Differentiation -- immunology KW - Calcium -- pharmacology KW - Cell Differentiation -- drug effects KW - Cell Division KW - Epidermis -- immunology KW - Epidermis -- cytology KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78764011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Signal+transduction+for+proliferation+and+differentiation+in+keratinocytes.&rft.au=Yuspa%2C+S+H%3BHennings%2C+H%3BTucker%2C+R+W%3BJaken%2C+S%3BKilkenny%2C+A+E%3BRoop%2C+D+R&rft.aulast=Yuspa&rft.aufirst=S&rft.date=1988-01-01&rft.volume=548&rft.issue=&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-19 N1 - Date created - 1989-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of activated proto-oncogenes in chemically transformed Syrian hamster embryo cells. AN - 78760195; 3074813 AB - The Syrian hamster embryo (SHE) cell transformation model has been used by many investigators to study the multistep process of neoplastic transformation induced by chemical carcinogens. In this study we have attempted to determine if activated proto-oncogenes are present in the transformed cells induced by a variety of chemical carcinogens. Twelve carcinogen-induced hamster cell lines, established by treatment of normal SHE cells with benzo[a]pyrene, diethylstilbestrol, or asbestos, were examined. One spontaneously transformed cell line (BHK-A) was also studied. Some of the cell lines were also tested for oncogene activation at the preneoplastic stage, before they acquired tumorigenic potential. DNAs from normal, preneoplastic, and neoplastic cells were tested by transfection into mouse NIH 3T3 cells, and morphologically transformed foci were scored on the contact-inhibited monolayer of 3T3 cells. The frequency of focus formation for normal SHE cell DNA was less than 0.0008 foci/microgram DNA, while approximately 40% (5 of 12) of the DNAs from carcinogen-induced, tumorigenic hamster cell lines induced foci at a frequency of greater than or equal to 0.012 foci/microgram DNA. The other seven carcinogen-induced cell lines and the BHK-A cells were negative (less than 0.002 foci/microgram DNA). When the DNAs from transformed foci induced by the five positive cell lines were retransfected into NIH 3T3 cells, the frequency of secondary foci of 3T3 cells was as much as 50-fold higher (1.34 foci/microgram DNA) than with the primary transfectants. DNAs from transformed foci or tumors derived from transformed foci were screened by Southern blot analyses with known oncogenes and with a hamster repetitive DNA probe for the presence of transfected hamster oncogenes.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Molecular carcinogenesis AU - Gilmer, T M AU - Annab, L A AU - Barrett, J C AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 180 EP - 188 VL - 1 IS - 3 SN - 0899-1987, 0899-1987 KW - Asbestos KW - 1332-21-4 KW - Benzo(a)pyrene KW - 3417WMA06D KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Genes, ras KW - Animals KW - Oncogenes KW - Transfection KW - Embryo, Mammalian -- cytology KW - Mesocricetus KW - Cell Line, Transformed KW - Cricetinae KW - Cell Transformation, Neoplastic -- chemically induced KW - Gene Expression Regulation KW - Proto-Oncogenes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78760195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Characterization+of+activated+proto-oncogenes+in+chemically+transformed+Syrian+hamster+embryo+cells.&rft.au=Gilmer%2C+T+M%3BAnnab%2C+L+A%3BBarrett%2C+J+C&rft.aulast=Gilmer&rft.aufirst=T&rft.date=1988-01-01&rft.volume=1&rft.issue=3&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-27 N1 - Date created - 1989-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neoplastic transformation and lineage switching of rat liver epithelial cells by retrovirus-associated oncogenes. AN - 78759494; 3074814 AB - Tumors produced by a chemically transformed rat liver epithelial (RLE) cell line and its single cell-derived clonal subpopulations demonstrate wide-ranging morphological presentations including carcinomas, sarcomas, "mixed epithelial-mesenchymal" tumors, and undifferentiated tumors [Am J Pathol 127:168-181, 1987]. To address the question of heterogeneity of tumors derived from transformed RLE cells, we have used recombinant retroviruses containing the following transforming oncogenes: v-raf (3611-MSV), v-raflv-myc (J2), v-myc (J5), and v-Ha-ras (pRNR16). All of the oncogenes, with the exception of v-myc (J5), were efficient transforming agents in the RLE cells. Tumors derived from the v-raf- and, to a lesser extent, those from v-Ha-ras-transformed RLE cells showed mixed epithelial-mesenchymal morphology, whereas the combination of v-raflv-myc (J2) consistently produced differentiated trabecular carcinomas. These data suggest that the lineage commitment of the RLE cells can be perturbed by a single transforming oncogene and that different tumor types derived from these cells may reflect the expression of a selective oncogene or a combination of oncogenes. JF - Molecular carcinogenesis AU - Garfield, S AU - Huber, B E AU - Nagy, P AU - Cordingley, M G AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 189 EP - 195 VL - 1 IS - 3 SN - 0899-1987, 0899-1987 KW - Index Medicus KW - Rats KW - Genes, ras KW - Animals KW - Liver -- cytology KW - Epithelial Cells KW - Tumor Cells, Cultured -- pathology KW - Gene Expression Regulation KW - Cell Transformation, Viral KW - Oncogenes KW - Genes, Switch KW - Cell Transformation, Neoplastic -- genetics KW - Genes, Regulator UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78759494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Neoplastic+transformation+and+lineage+switching+of+rat+liver+epithelial+cells+by+retrovirus-associated+oncogenes.&rft.au=Garfield%2C+S%3BHuber%2C+B+E%3BNagy%2C+P%3BCordingley%2C+M+G%3BThorgeirsson%2C+S+S&rft.aulast=Garfield&rft.aufirst=S&rft.date=1988-01-01&rft.volume=1&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-27 N1 - Date created - 1989-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The treatment of metastatic breast cancer with 5-fluorouracil and leucovorin. AN - 78756682; 3266821 JF - Advances in experimental medicine and biology AU - Allegra, C J AU - Egan, G F AU - Drake, J C AU - Steinberg, S M AU - Swain, S M AD - Clinical Pharmacology Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 107 EP - 112 VL - 244 SN - 0065-2598, 0065-2598 KW - Thymidylate Synthase KW - EC 2.1.1.45 KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Fluorouracil -- administration & dosage KW - Thymidylate Synthase -- antagonists & inhibitors KW - Drug Evaluation KW - Drug Administration Schedule KW - Leucovorin -- administration & dosage KW - Humans KW - Neoplasm Metastasis KW - Female KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78756682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=The+treatment+of+metastatic+breast+cancer+with+5-fluorouracil+and+leucovorin.&rft.au=Allegra%2C+C+J%3BEgan%2C+G+F%3BDrake%2C+J+C%3BSteinberg%2C+S+M%3BSwain%2C+S+M&rft.aulast=Allegra&rft.aufirst=C&rft.date=1988-01-01&rft.volume=244&rft.issue=&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-14 N1 - Date created - 1989-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Molecular cloning of mouse epidermal cystatin A and detection of regulated expression in differentiation and tumorigenesis. AN - 78753150; 2471537 AB - A gamma gt 11 cDNA expression library representing mouse epidermis mRNA was screened with polyclonal rabbit antiserum directed against 10-13 kDa epidermal antigens that had previously been shown to be regulated during epidermal differentiation. A cDNA clone was detected and isolated and its identity as the coding sequence for one of the antigens was confirmed by translation of hybrid-selected mRNA from mouse epidermis. The cDNA sequence predicted a peptide homologous to the reported sequence of rat epidermis cystatin A, a thiol proteinase inhibitor. This identification was confirmed by cross-reactivity of the gamma clone fusion protein with authentic antiserum to rat epidermis cystatin A. Southern gel analysis showed that mouse DNA may contain several closely related genes homologous to the cystatin probe. An mRNA of about 0.6 kb from epidermis and cultured mouse epidermal cells hybridized with the cystatin probe on northern analysis. The abundance of the message was high in cultured basal cells and was selectively diminished by inducing terminal differentiation in culture with an elevated Ca2+ concentration in the medium. Cystatin message was abundant in chemically induced mouse skin papillomas but reduced in carcinomas. In epidermis, mRNA was localized to the less differentiated basal and lower spinous layers by in situ hybridization. Regulation of expression of cystatin A in epidermis and tumors suggests that it may be important in the control of normal keratinocyte proliferation and differentiation and in malignant conversion. JF - Molecular carcinogenesis AU - Hawley-Nelson, P AU - Roop, D R AU - Cheng, C K AU - Krieg, T M AU - Yuspa, S H AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 202 EP - 211 VL - 1 IS - 3 SN - 0899-1987, 0899-1987 KW - Cysteine Proteinase Inhibitors KW - 0 KW - Protease Inhibitors KW - RNA, Messenger KW - Keratins KW - 68238-35-7 KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Keratins -- physiology KW - Base Sequence KW - Blotting, Southern KW - Epidermis -- cytology KW - Cell Differentiation KW - Mice KW - Gene Expression Regulation KW - Amino Acid Sequence KW - Nucleic Acid Hybridization KW - RNA, Messenger -- isolation & purification KW - Cross Reactions KW - Skin Neoplasms -- genetics KW - Protease Inhibitors -- genetics KW - Cloning, Molecular UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78753150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Molecular+cloning+of+mouse+epidermal+cystatin+A+and+detection+of+regulated+expression+in+differentiation+and+tumorigenesis.&rft.au=Hawley-Nelson%2C+P%3BRoop%2C+D+R%3BCheng%2C+C+K%3BKrieg%2C+T+M%3BYuspa%2C+S+H&rft.aulast=Hawley-Nelson&rft.aufirst=P&rft.date=1988-01-01&rft.volume=1&rft.issue=3&rft.spage=202&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-27 N1 - Date created - 1989-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Implication of protein oxidation in protein turnover, aging, and oxygen toxicity. AN - 78752432; 3150666 AB - It is evident from the results summarized here that a variety of MFO systems catalyze the oxidation inactivation of enzymes. This likely involves site-directed Fenton-chemistry in which Fe(II) bound to metal binding sites on the protein undergoes peroxidation to form active oxygen species that convert proximal amino acid residues to carbonyl derivatives. Such oxidation is likely involved in the accumulation of altered enzymes during aging, in premature aging diseases, in the killing of bacteria by neutrophils and in protein turnover. In view of these results, the possibility that protein oxidation is implicated in various diseases, viz, arthritis, pulmonary dysfunction, and carcinogenesis deserves consideration. JF - Basic life sciences AU - Stadtman, E R AU - Oliver, C N AU - Levine, R L AU - Fucci, L AU - Rivett, A J AD - Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 331 EP - 339 VL - 49 SN - 0090-5542, 0090-5542 KW - Enzymes KW - 0 KW - Peptides KW - Edetic Acid KW - 9G34HU7RV0 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Space life sciences KW - Animals KW - Enzyme Stability KW - Aging KW - Edetic Acid -- pharmacology KW - Oxygen -- toxicity KW - Oxygen -- pharmacology KW - Enzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78752432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+life+sciences&rft.atitle=Implication+of+protein+oxidation+in+protein+turnover%2C+aging%2C+and+oxygen+toxicity.&rft.au=Stadtman%2C+E+R%3BOliver%2C+C+N%3BLevine%2C+R+L%3BFucci%2C+L%3BRivett%2C+A+J&rft.aulast=Stadtman&rft.aufirst=E&rft.date=1988-01-01&rft.volume=49&rft.issue=&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Basic+life+sciences&rft.issn=00905542&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-23 N1 - Date created - 1989-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neoplastic transformation of a human bronchial epithelial cell line by a recombinant retrovirus encoding viral Harvey ras. AN - 78751973; 2855021 AB - Activated ras oncogenes have previously been implicated in the pathogenesis of human lung carcinomas. A v-Ha-ras-containing retrovirus, Zip-ras, was generated by inserting the coding region of the v-Ha-ras oncogene into the Zip-NeoSV(X) [Cepko et al., Cell 37:1053-1062, 1984] retroviral vector. Amphotrophic Zip-ras retrovirus was used to infect an SV40 large T antigen-positive immortalized cell line, BEAS-2B, derived from normal bronchial epithelial cells, the predominant progenitor cells of human lung carcinomas. Zip-ras-infected BEAS-2B cells selected for G418 resistance formed anaplastic carcinomas in 12 of 15 athymic nude mice (latency 3 wk), whereas Zip-NeoSV(X)-infected BEAS-2B control cultures inoculated into 12 nude mice formed no tumors after a minimum of 7 mo. Tumor cell lines were established and demonstrated to be of human epithelial origin and to express v-Ha-ras p21 protein. A common feature of the tumor cell lines was an increase in ploidy. The increased efficiency of neoplastic transformation by v-Ha-ras of cell lines as compared with our previous results with normal bronchial epithelial cells [Yoakum et al., Science 227:1174-1179, 1985] is consistent with the hypothesis that the "immortalization" step is rate-limiting in in vitro human epithelial cell carcinogenesis. JF - Molecular carcinogenesis AU - Amstad, P AU - Reddel, R R AU - Pfeifer, A AU - Malan-Shibley, L AU - Mark, G E AU - Harris, C C AD - Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 151 EP - 160 VL - 1 IS - 3 SN - 0899-1987, 0899-1987 KW - Isoenzymes KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Simian virus 40 -- genetics KW - Mice KW - Mice, Nude KW - Bronchial Neoplasms -- pathology KW - Epithelial Cells KW - Recombination, Genetic KW - Carcinogenicity Tests KW - Tumor Cells, Cultured -- pathology KW - Cell Line KW - Cell Transformation, Viral KW - Genes, ras KW - Bronchi -- cytology KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78751973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Neoplastic+transformation+of+a+human+bronchial+epithelial+cell+line+by+a+recombinant+retrovirus+encoding+viral+Harvey+ras.&rft.au=Amstad%2C+P%3BReddel%2C+R+R%3BPfeifer%2C+A%3BMalan-Shibley%2C+L%3BMark%2C+G+E%3BHarris%2C+C+C&rft.aulast=Amstad&rft.aufirst=P&rft.date=1988-01-01&rft.volume=1&rft.issue=3&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-27 N1 - Date created - 1989-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Oxidative modification of enzymes during aging and acute oxidative stress. AN - 78751430; 2907971 JF - Basic life sciences AU - Starke-Reed, P E AU - Oliver, C N AD - Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 537 EP - 540 VL - 49 SN - 0090-5542, 0090-5542 KW - Enzymes KW - 0 KW - Mixed Function Oxygenases KW - EC 1.- KW - Glucosephosphate Dehydrogenase KW - EC 1.1.1.49 KW - Glutamate-Ammonia Ligase KW - EC 6.3.1.2 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Animals KW - Glutamate-Ammonia Ligase -- metabolism KW - Kinetics KW - Aging KW - Glucosephosphate Dehydrogenase -- metabolism KW - Liver -- enzymology KW - Mixed Function Oxygenases -- metabolism KW - Oxygen -- toxicity KW - Liver -- growth & development KW - Liver -- drug effects KW - Enzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78751430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+life+sciences&rft.atitle=Oxidative+modification+of+enzymes+during+aging+and+acute+oxidative+stress.&rft.au=Starke-Reed%2C+P+E%3BOliver%2C+C+N&rft.aulast=Starke-Reed&rft.aufirst=P&rft.date=1988-01-01&rft.volume=49&rft.issue=&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Basic+life+sciences&rft.issn=00905542&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-23 N1 - Date created - 1989-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The medical and metabolic consequences of administration of sodium acetate. AN - 78750531; 2854950 AB - 1. The standard total parenteral nutrition, peritoneal dialysis, hemodialysis and many surgical fluids in use today contain 36 to 45 mM D,L-lactate or 2 to 140 mM acetate whereas the normal blood level of D-lactate is 0.02 mM L-lactate 0.5 to 5 mM and acetate 0.1 nM. The reasons for the continued use in patients of such unphysiological concentrations of these anions appear to be historic. 2. Administration of similar concentrations of these anions to the rat causes widespread metabolic disturbances which mimic many of the untoward complications associated with current parenteral and dialysis therapy. Understanding of the mechanisms attendant upon the metabolism of these anions may serve as a guide for designing improved parenteral fluids for human patients. 3. Elevation of blood D-lactate to 5 mM is associated with cerebral dysfunction in human patients. 4. Acetate stimulates the release of the inflammatory leukokine, interleukin-1 from human monocytes. Use of 35 to 45 mM acetate in peritoneal dialysis fluids led to peritoneal fibrosis. Patients exposed to acetate containing hemodialysis fluids have 12-fold elevation in their plasma interleukin-1 levels. 5. Administration of 20 mM sodium acetate to rats leads to a number of metabolic disturbances similar to those seen in human dialysis patients: (a) Acetate elevates blood glucose in the rat and may contribute to the exacerbation of the carbohydrate intolerance seen in uremic patients. (b) Acetate increases the levels of hepatic malonyl CoA, the rate controlling substrate of fatty acid synthesis and may exacerbate the hypertriglyceridemia characteristic of dialysis patients. (c) Acetate administration in the rat leads to a decrease in the cytosolic phosphorylation potential, reduction of the redox state of the free cytosolic NAD couple and paradoxical oxidation of the mitochondrial NAD couple in a pattern analogous to that produced by uncouplers of oxidative phosphorylation and may account in part for the elevation of temperature reported in patients undergoing hemodialysis with acetate. (d) Acetate administration in the rat leads to an increase in intracellular phosphorylated intermediates, adenine nucleotides, inorganic phosphate, inorganic pyrophosphate, calcium and magnesium. On cessation of acetate metabolism, the inorganic phosphate and calcium accumulated intracellularly leave the intracellular space. In patients undergoing hemodialysis, the blood phosphate returns to predialysis levels, within 6 hr after the completion of treatment, leaving significant numbers of patients with chronic hyperphosphatemia and the multiple complications attendant to that state.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Advances in enzyme regulation AU - Veech, R L AU - Gitomer, W L AD - Laboratory of Metabolism and Molecular Biology, NIAAA, Rockville, Maryland 20852. Y1 - 1988 PY - 1988 DA - 1988 SP - 313 EP - 343 VL - 27 SN - 0065-2571, 0065-2571 KW - Acetates KW - 0 KW - Dialysis Solutions KW - Diphosphates KW - Magnesium Compounds KW - Phosphates KW - magnesium pyrophosphate KW - AL34Y660JV KW - Magnesium KW - I38ZP9992A KW - Glucose KW - IY9XDZ35W2 KW - Acetic Acid KW - Q40Q9N063P KW - Coenzyme A KW - SAA04E81UX KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Phosphates -- blood KW - Coenzyme A -- metabolism KW - Diphosphates -- metabolism KW - Glucose -- metabolism KW - Humans KW - Liver -- metabolism KW - Homeostasis -- drug effects KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - Calcium -- metabolism KW - Magnesium -- metabolism KW - Mitochondria -- metabolism KW - Male KW - Dialysis Solutions -- adverse effects KW - Parenteral Nutrition -- adverse effects KW - Acetates -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78750531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+enzyme+regulation&rft.atitle=The+medical+and+metabolic+consequences+of+administration+of+sodium+acetate.&rft.au=Veech%2C+R+L%3BGitomer%2C+W+L&rft.aulast=Veech&rft.aufirst=R&rft.date=1988-01-01&rft.volume=27&rft.issue=&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Advances+in+enzyme+regulation&rft.issn=00652571&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-03 N1 - Date created - 1989-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The National Cancer Institute experience with early and late effects of combined modality therapy in small cell lung cancer. AN - 78749742; 2854442 JF - Antibiotics and chemotherapy AU - Johnson, B E AU - Glatstein, E AU - Ihde, D C AD - NCI-Navy Medical Oncology Branch, Bethesda, Md. Y1 - 1988 PY - 1988 DA - 1988 SP - 210 EP - 212 VL - 41 SN - 0066-4758, 0066-4758 KW - Index Medicus KW - United States KW - Combined Modality Therapy KW - Humans KW - National Institutes of Health (U.S.) KW - Clinical Trials as Topic KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Time Factors KW - Radiation Injuries KW - Male KW - Female KW - Carcinoma, Small Cell -- therapy KW - Lung Neoplasms -- radiotherapy KW - Carcinoma, Small Cell -- mortality KW - Lung Neoplasms -- drug therapy KW - Carcinoma, Small Cell -- radiotherapy KW - Lung Neoplasms -- therapy KW - Lung Neoplasms -- mortality KW - Carcinoma, Small Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78749742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antibiotics+and+chemotherapy&rft.atitle=The+National+Cancer+Institute+experience+with+early+and+late+effects+of+combined+modality+therapy+in+small+cell+lung+cancer.&rft.au=Johnson%2C+B+E%3BGlatstein%2C+E%3BIhde%2C+D+C&rft.aulast=Johnson&rft.aufirst=B&rft.date=1988-01-01&rft.volume=41&rft.issue=&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Antibiotics+and+chemotherapy&rft.issn=00664758&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-26 N1 - Date created - 1989-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A Ca2+-dependent signal transduction system participates in coupling expression of some cAMP-dependent prespore genes to the cell surface receptor. AN - 78748649; 2854023 AB - Elevated levels of cAMP are essential for the expression of many postaggregation prespore and prestalk mRNA species and for the suppression of some growth phase mRNAs. Here we review evidence that this regulation is mediated by cAMP interacting at the cell surface receptor. These effects of cAMP on gene expression can occur under conditions where the receptor-associated adenylate cyclase is inactivated and in concentrations that are consistent with receptor-binding. A number of differences are noted in the mechanism by which cAMP regulates prespore and prestalk genes. Finally, evidence is reviewed for the role of a Ca2+-dependent signal transduction system in coupling the expression of some of the prespore mRNAs to the cAMP receptor. This signal transduction system does not appear to be involved in the expression of the cAMP-dependent prestalk gene. JF - Developmental genetics AU - Blumberg, D D AU - Comer, J F AU - Higinbotham, K G AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, Maryland. Y1 - 1988 PY - 1988 DA - 1988 SP - 359 EP - 369 VL - 9 IS - 4-5 SN - 0192-253X, 0192-253X KW - Receptors, Cyclic AMP KW - 0 KW - Cyclic AMP KW - E0399OZS9N KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Spores, Fungal -- physiology KW - Dictyostelium -- genetics KW - Receptors, Cyclic AMP -- physiology KW - Genes, Fungal KW - Calcium -- physiology KW - Dictyostelium -- physiology KW - Transcription, Genetic KW - Gene Expression Regulation KW - Cyclic AMP -- physiology KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78748649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+genetics&rft.atitle=A+Ca2%2B-dependent+signal+transduction+system+participates+in+coupling+expression+of+some+cAMP-dependent+prespore+genes+to+the+cell+surface+receptor.&rft.au=Blumberg%2C+D+D%3BComer%2C+J+F%3BHiginbotham%2C+K+G&rft.aulast=Blumberg&rft.aufirst=D&rft.date=1988-01-01&rft.volume=9&rft.issue=4-5&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Developmental+genetics&rft.issn=0192253X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-26 N1 - Date created - 1989-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Oxidative modification of enzymes by stimulated neutrophils. AN - 78744757; 2907973 JF - Basic life sciences AU - Oliver, C N AD - Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 839 EP - 844 VL - 49 SN - 0090-5542, 0090-5542 KW - Glutamate-Ammonia Ligase KW - EC 6.3.1.2 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Oxidation-Reduction KW - Humans KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Differentiation KW - Cell Line KW - Neutrophils -- drug effects KW - Glutamate-Ammonia Ligase -- antagonists & inhibitors KW - Neutrophils -- physiology KW - Escherichia coli -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78744757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+life+sciences&rft.atitle=Oxidative+modification+of+enzymes+by+stimulated+neutrophils.&rft.au=Oliver%2C+C+N&rft.aulast=Oliver&rft.aufirst=C&rft.date=1988-01-01&rft.volume=49&rft.issue=&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Basic+life+sciences&rft.issn=00905542&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-23 N1 - Date created - 1989-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reduction of nitroheterocyclic drugs by ascorbate and catecholamines: a possible mechanism for the neurotoxicity of nitroheterocyclic drugs. AN - 78744697; 3250533 JF - Basic life sciences AU - Rao, D N AU - Mason, R P AD - Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 787 EP - 794 VL - 49 SN - 0090-5542, 0090-5542 KW - Catecholamines KW - 0 KW - Free Radicals KW - Neurotoxins KW - Metronidazole KW - 140QMO216E KW - Misonidazole KW - 8FE7LTN8XE KW - Nitrofurantoin KW - 927AH8112L KW - Catalase KW - EC 1.11.1.6 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Catalase -- metabolism KW - Animals KW - Oxygen Consumption KW - Biotransformation KW - Kinetics KW - Superoxide Dismutase -- metabolism KW - Male KW - Nitrofurantoin -- metabolism KW - Catecholamines -- metabolism KW - Metronidazole -- metabolism KW - Liver -- metabolism KW - Misonidazole -- metabolism KW - Ascorbic Acid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78744697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+life+sciences&rft.atitle=Reduction+of+nitroheterocyclic+drugs+by+ascorbate+and+catecholamines%3A+a+possible+mechanism+for+the+neurotoxicity+of+nitroheterocyclic+drugs.&rft.au=Rao%2C+D+N%3BMason%2C+R+P&rft.aulast=Rao&rft.aufirst=D&rft.date=1988-01-01&rft.volume=49&rft.issue=&rft.spage=787&rft.isbn=&rft.btitle=&rft.title=Basic+life+sciences&rft.issn=00905542&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-23 N1 - Date created - 1989-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Toxicity and carcinogenicity studies of phenylephrine hydrochloride in F344/N rats and B6C3F1 mice. AN - 78737559; 3243185 AB - Phenylephrine HCl was incorporated into feed given to male and female F344/N rats and B6C3F1 mice in studies of 14 days, 12 weeks, and 2 years duration. In 12-week studies, body weight gains decreased with dose, and deaths of male rats and mice occurred at concentrations of 5,000 ppm and above; however, no organ-specific toxicity was evident. During 2-year studies, body weights of rats receiving diets at 620 and 1,250 ppm and mice at 1,250 and 2,500 ppm ranged up to 16% less than control. Survival of high dose male rats was substantially greater than controls. Survivals of other dose groups of rats and mice were similar to controls. Chronic focal inflammation of the liver, and inflammation of the prostate were increased in dosed rats. No increases in neoplasms were observed in rats or mice consuming diets containing phenylephrine HCl for 2 years. The incidences of mononuclear cell leukemia and pheochromocytomas of the adrenal gland were decreased in dosed male rats. Approximate time weighted average doses ranged up to 54 mg/kg/day for rats and 280 mg/kg/day for mice during the 2-year studies. JF - Drug and chemical toxicology AU - Bucher, J R AU - Huff, J AU - Haseman, J K AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 355 EP - 370 VL - 11 IS - 4 SN - 0148-0545, 0148-0545 KW - Phenylephrine KW - 1WS297W6MV KW - Index Medicus KW - Rats KW - Prostate -- drug effects KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Sex Factors KW - Liver -- drug effects KW - Body Weight -- drug effects KW - Mice KW - Hematopoietic System -- drug effects KW - Adrenal Glands -- drug effects KW - Male KW - Female KW - Phenylephrine -- toxicity KW - Carcinogenicity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78737559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+chemical+toxicology&rft.atitle=Toxicity+and+carcinogenicity+studies+of+phenylephrine+hydrochloride+in+F344%2FN+rats+and+B6C3F1+mice.&rft.au=Bucher%2C+J+R%3BHuff%2C+J%3BHaseman%2C+J+K&rft.aulast=Bucher&rft.aufirst=J&rft.date=1988-01-01&rft.volume=11&rft.issue=4&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Drug+and+chemical+toxicology&rft.issn=01480545&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-26 N1 - Date created - 1989-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol intoxication reduces visual sustained attention. AN - 78729092; 3149763 AB - Effects of alcohol intoxication on visual sustained attention were studied using a vigilance task entailing detection of degraded target stimuli. Data were obtained in separate sessions under four ethanol doses, ranging from 0 (placebo) to 1.05 g/kg lean body weight, with periodic maintenance dosing of 0.12 g/kg. Intoxication lowered the overall level of detection performance, and in addition produced dose-related increases in the rate of performance decrement over time. Analysis of performance data using techniques derived from Signal Detection Theory indicated that the decrements were due specifically to alterations in perceptual sensitivity. Examination of eye movements and blinks indicated that the effects of ethanol were not mediated peripherally. Rather, alcohol appears to have deleterious effects on central processing capacity and the availability of capacity over time. The alcohol-related failure of sustained attention may contribute to increased accident risk in tasks requiring continuous performance. JF - Psychopharmacology AU - Rohrbaugh, J W AU - Stapleton, J M AU - Parasuraman, R AU - Frowein, H W AU - Adinoff, B AU - Varner, J L AU - Zubovic, E A AU - Lane, E A AU - Eckardt, M J AU - Linnoila, M AD - Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 442 EP - 446 VL - 96 IS - 4 SN - 0033-3158, 0033-3158 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Reaction Time -- drug effects KW - Eye Movements -- drug effects KW - Ethanol -- blood KW - Psychomotor Performance -- drug effects KW - Humans KW - Adult KW - Male KW - Alcoholic Intoxication -- psychology KW - Attention -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78729092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Alcohol+intoxication+reduces+visual+sustained+attention.&rft.au=Rohrbaugh%2C+J+W%3BStapleton%2C+J+M%3BParasuraman%2C+R%3BFrowein%2C+H+W%3BAdinoff%2C+B%3BVarner%2C+J+L%3BZubovic%2C+E+A%3BLane%2C+E+A%3BEckardt%2C+M+J%3BLinnoila%2C+M&rft.aulast=Rohrbaugh&rft.aufirst=J&rft.date=1988-01-01&rft.volume=96&rft.issue=4&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-02 N1 - Date created - 1989-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acceptance of HIV-antibody testing by persons seeking outpatient treatment for cocaine abuse. AN - 78718470; 3236388 AB - One hundred of 101 applicants for outpatient treatment for cocaine abuse consented to voluntary HIV-antibody testing when the testing was offered as an option within the medical assessment at intake. Twelve applicants tested HIV-antibody positive; eight of these had injected drugs parenterally with syringes and needles used by other addicts and four had never taken drugs intravenously. There were no significant differences between HIV-antibody positive and negative applicants regarding the percentages who completed the evaluation, began treatment, and completed four weeks of treatment. A subgroup of 48 patients were interviewed regarding their knowledge of HIV infection, AIDS, and risk factors associated with transmission of HIV. All 48 patients had heard of HIV, AIDS, and recommendations that they use condoms as well as clean syringes and needles. None of the 48 patients reported that they used condoms; 10 reported reduced sexual activity and number of sexual partners; and none of those who shared needles reported that they had discontinued sharing other addicts' drug paraphernalia. The authors conclude that on-site, voluntary HIV-antibody testing for drug abusing patients entering treatment appears feasible and is not a deterrent to persons entering and continuing in treatment for drug abuse. The finding that persons at risk for HIV infection have knowledge of risk factors and have not changed risk-taking behaviors associated with HIV contagion points out the urgent need for further education and counseling. JF - Journal of substance abuse treatment AU - Weddington, W W AU - Brown, B S AD - Addiction Research Center/National Institute on Drug Abuse, Baltimore, MD. Y1 - 1988 PY - 1988 DA - 1988 SP - 145 EP - 149 VL - 5 IS - 3 SN - 0740-5472, 0740-5472 KW - HIV Antibodies KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - AIDS/HIV KW - Risk Factors KW - Humans KW - HIV Seropositivity -- diagnosis KW - Adult KW - Middle Aged KW - Ambulatory Care Facilities KW - Male KW - Female KW - Acquired Immunodeficiency Syndrome -- diagnosis KW - Substance-Related Disorders -- therapy KW - Patient Acceptance of Health Care KW - HIV Antibodies -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78718470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Acceptance+of+HIV-antibody+testing+by+persons+seeking+outpatient+treatment+for+cocaine+abuse.&rft.au=Weddington%2C+W+W%3BBrown%2C+B+S&rft.aulast=Weddington&rft.aufirst=W&rft.date=1988-01-01&rft.volume=5&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-08 N1 - Date created - 1989-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mammalian genome organization: an evolutionary view. AN - 78715849; 3071253 JF - Annual review of genetics AU - O'Brien, S J AU - Seuánez, H N AU - Womack, J E AD - Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701-1013. Y1 - 1988 PY - 1988 DA - 1988 SP - 323 EP - 351 VL - 22 SN - 0066-4197, 0066-4197 KW - Index Medicus KW - Animals KW - Humans KW - Chromosomes, Human KW - Genes KW - Biological Evolution KW - Mammals -- genetics KW - Chromosome Mapping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78715849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+genetics&rft.atitle=Mammalian+genome+organization%3A+an+evolutionary+view.&rft.au=O%27Brien%2C+S+J%3BSeu%C3%A1nez%2C+H+N%3BWomack%2C+J+E&rft.aulast=O%27Brien&rft.aufirst=S&rft.date=1988-01-01&rft.volume=22&rft.issue=&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+genetics&rft.issn=00664197&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-10 N1 - Date created - 1989-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aberrations of growth and differentiation pathways during neoplastic transformation of human epithelial cells. AN - 78715646; 3069724 JF - IARC scientific publications AU - Harris, C C AU - Brash, D E AU - Lechner, J F AU - Mark, G AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 139 EP - 148 IS - 92 SN - 0300-5038, 0300-5038 KW - Index Medicus KW - Phenotype KW - Animals KW - Humans KW - Cell Differentiation KW - Gene Expression Regulation KW - Cell Transformation, Neoplastic -- pathology KW - Epithelium -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78715646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=Aberrations+of+growth+and+differentiation+pathways+during+neoplastic+transformation+of+human+epithelial+cells.&rft.au=Harris%2C+C+C%3BBrash%2C+D+E%3BLechner%2C+J+F%3BMark%2C+G&rft.aulast=Harris&rft.aufirst=C&rft.date=1988-01-01&rft.volume=&rft.issue=92&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-04 N1 - Date created - 1989-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aberrant differentiation in mouse skin carcinogenesis. AN - 78713415; 2466787 JF - IARC scientific publications AU - Yuspa, S H AU - Kilkenny, A AU - Roop, D R AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 3 EP - 10 IS - 92 SN - 0300-5038, 0300-5038 KW - Keratins KW - 68238-35-7 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Keratins -- metabolism KW - Calcium -- metabolism KW - Animals KW - Cell Transformation, Neoplastic -- pathology KW - Neoplastic Stem Cells -- pathology KW - Cell Differentiation KW - Mice KW - Skin Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78713415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=Aberrant+differentiation+in+mouse+skin+carcinogenesis.&rft.au=Yuspa%2C+S+H%3BKilkenny%2C+A%3BRoop%2C+D+R&rft.aulast=Yuspa&rft.aufirst=S&rft.date=1988-01-01&rft.volume=&rft.issue=92&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-04 N1 - Date created - 1989-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lung cancer chemoprevention with retinol palmitate. Preliminary data from a randomized trial on stage Ia non small-cell lung cancer. AN - 78699729; 2852945 AB - On the basis of epidemiologic and experimental evidence of an anticancer activity of vitamin A, a randomized clinical trial was activated in Milan with the aim of evaluating if retinol palmitate administration (per os, 300,000 I.U. daily) after complete resection of stage Ia non small-cell lung cancer could reduce the occurrence of cancer relapses (within 3 years) and/or the occurrence of new primary tumors (beyond 3 years). By September 1987, 181 patients had entered the trial: 87 in the treatment arm and 94 in the control arm. After a median follow-up of 14 months, the interim analysis was focused on the evaluation of toxicity, compliance, and early recurrences. Although the large majority of patients were affected by skin and mucous membrane desquamation and dryness during treatment, these symptoms were generally mild and well tolerated, and never induced the patient to stop the treatment. Other side effects like headache, hair loss, itching, or dyspepsia were detected at a much lower frequency. Only in 3 patients the treatment was interrupted, because of signs or symptoms potentially related to vitamin A administration. At the time of the analysis, a total of 42 (23%) patients had relapsed; 16 (18%) in the treated arm, and 26 (28%) in the control arm. The largest difference between treated patients and controls was observed for bone metastases (2 vs. 7) and brain metastases (3 vs. 6), and for squamous histology (6 vs. 11). Only 2 cases of new primary cancer were detected, both in the control arm. These results are promising both in terms of tolerance and efficacy of treatment, but given the short median follow-up they must be very cautiously interpreted. A longer follow-up is necessary to establish whether a significant proportion of early recurrences could be prevented, or only delayed, by vitamin A administration. JF - Acta oncologica (Stockholm, Sweden) AU - Pastorino, U AU - Soresi, E AU - Clerici, M AU - Chiesa, G AU - Belloni, P A AU - Ongari, M AU - Valente, M AU - Ravasi, G AD - Department of Chest Surgery, National Cancer Institute, Milan, Italy. Y1 - 1988 PY - 1988 DA - 1988 SP - 773 EP - 782 VL - 27 IS - 6b SN - 0284-186X, 0284-186X KW - Vitamin A KW - 11103-57-4 KW - Index Medicus KW - Infant KW - Neoplasm Staging KW - Random Allocation KW - Humans KW - Adult KW - Infant, Newborn KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Child KW - Neoplasm Recurrence, Local KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Vitamin A -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- prevention & control KW - Vitamin A -- adverse effects KW - Lung Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78699729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+oncologica+%28Stockholm%2C+Sweden%29&rft.atitle=Lung+cancer+chemoprevention+with+retinol+palmitate.+Preliminary+data+from+a+randomized+trial+on+stage+Ia+non+small-cell+lung+cancer.&rft.au=Pastorino%2C+U%3BSoresi%2C+E%3BClerici%2C+M%3BChiesa%2C+G%3BBelloni%2C+P+A%3BOngari%2C+M%3BValente%2C+M%3BRavasi%2C+G&rft.aulast=Pastorino&rft.aufirst=U&rft.date=1988-01-01&rft.volume=27&rft.issue=6b&rft.spage=773&rft.isbn=&rft.btitle=&rft.title=Acta+oncologica+%28Stockholm%2C+Sweden%29&rft.issn=0284186X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-26 N1 - Date created - 1989-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Rat liver cytosolic protein changes after ethanol exposure studied by two-dimensional electrophoresis. AN - 78696148; 3234333 AB - Rats were fed liquid food containing ethanol in concentrations ranging from 1-5% for 13 weeks. Livers were removed for histopathology and the liver cytosolic protein fraction was prepared and used for two-dimensional gel electrophoresis (2D-PAGE). Polypeptides were visualized by silver staining. Scanning was made for estimation of the relative abundance of protein in each polypeptide spot in the gels and for comparison between rats. Visual inspection and scanning of gels with the stained polypeptide spots obtained after equilibrium isoelectric focusing and non-equilibrium pH gradient electrophoresis revealed that: 1) within the control rat and ethanol-treated rat livers the numbers of polypeptide spots detected using isoelectric focusing in the first dimension were approximately 500 and for non-equilibrium pH gradient electrophoresis 400; 2) in the control group the variation in the estimated amount of protein in each spot was remarkably small; 3) pronounced differences in the relative abundance of protein in several of the spots was observed in the ethanol-exposed rats as compared to controls. Dose-response relations and possible causes for the effects of ethanol are discussed. JF - Electrophoresis AU - Wirth, P J AU - Vesterberg, O AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 47 EP - 53 VL - 9 IS - 1 SN - 0173-0835, 0173-0835 KW - Proteins KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Electrophoresis, Gel, Two-Dimensional KW - Image Processing, Computer-Assisted KW - Male KW - Cytosol -- metabolism KW - Liver -- drug effects KW - Ethanol -- pharmacology KW - Cytosol -- drug effects KW - Liver -- metabolism KW - Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78696148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electrophoresis&rft.atitle=Rat+liver+cytosolic+protein+changes+after+ethanol+exposure+studied+by+two-dimensional+electrophoresis.&rft.au=Wirth%2C+P+J%3BVesterberg%2C+O&rft.aulast=Wirth&rft.aufirst=P&rft.date=1988-01-01&rft.volume=9&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Electrophoresis&rft.issn=01730835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-27 N1 - Date created - 1989-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study. AN - 78686120; 3230208 AB - The pulmonary effects of hyperventilation following infusion of sodium salicylate into the cisterna magna was studied in 16 spontaneously breathing adult sheep. We found a fall in PaO2, a decrease in the static compliance of the respiratory system, abnormal chest roentgenographic films, and grossly abnormal lungs following 3.5 to 13 h of hyperventilation. A control group of 15 sheep (10 sheep similarly injected with sodium salicylate, but then sedated and paralyzed and ventilated at normal tidal volume and respiratory rate on a mechanical ventilator, and 5 sheep infused with saline alone and breathing spontaneously) showed no pulmonary or arterial blood gas abnormalities. We conclude that prolonged hyperventilation under the conditions of this experiment precipitated events that resulted in acute lung injury. JF - Intensive care medicine AU - Mascheroni, D AU - Kolobow, T AU - Fumagalli, R AU - Moretti, M P AU - Chen, V AU - Buckhold, D AD - National Institutes of Health, Laboratory of Technical Development, Bethesda, Maryland. Y1 - 1988 PY - 1988 DA - 1988 SP - 8 EP - 14 VL - 15 IS - 1 SN - 0342-4642, 0342-4642 KW - Sodium Salicylate KW - WIQ1H85SYP KW - Index Medicus KW - Animals KW - Sodium Salicylate -- adverse effects KW - Sheep KW - Respiration, Artificial KW - Lung Volume Measurements KW - Hyperventilation -- chemically induced KW - Hyperventilation -- complications KW - Respiratory Insufficiency -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78686120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intensive+care+medicine&rft.atitle=Acute+respiratory+failure+following+pharmacologically+induced+hyperventilation%3A+an+experimental+animal+study.&rft.au=Mascheroni%2C+D%3BKolobow%2C+T%3BFumagalli%2C+R%3BMoretti%2C+M+P%3BChen%2C+V%3BBuckhold%2C+D&rft.aulast=Mascheroni&rft.aufirst=D&rft.date=1988-01-01&rft.volume=15&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Intensive+care+medicine&rft.issn=03424642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-17 N1 - Date created - 1989-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human bronchial epithelial cells neoplastically transformed by v-Ki-ras: altered response to inducers of terminal squamous differentiation. AN - 78679115; 3067190 AB - Many human bronchial adenocarcinomas have been shown to contain an activated Ki-ras oncogene (Rodenhuis et al., N. Engl. J. Med. 317 929-935, 1987). To test the hypothesis that activated Ki-ras may be causally related to human bronchial carcinogenesis, v-Ki-ras oncogene was transferred into an established human bronchial epithelial cell line, BEAS-2B, by infection with Kirsten murine sarcoma virus (Ki-MSV) or by transfection with a plasmid containing the transforming region of Ki-MSV. These cells formed poorly differentiated adenocarcinomas in athymic nude mice. Cell lines established from these tumors expressed v-Ki-ras p21 protein and were highly tumorigenic. Whereas serum or transforming growth factor beta 1 induced the BEAS-2B cells at clonal density to undergo growth arrest and squamous differentiation, BEAS-2B cells containing activated ras genes were unaffected by transforming growth factor beta 1 and were mitogenically stimulated by serum. JF - Oncogene research AU - Reddel, R R AU - Ke, Y AU - Kaighn, M E AU - Malan-Shibley, L AU - Lechner, J F AU - Rhim, J S AU - Harris, C C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 401 EP - 408 VL - 3 IS - 4 SN - 0890-6467, 0890-6467 KW - Growth Substances KW - 0 KW - Transforming Growth Factors KW - 76057-06-2 KW - Index Medicus KW - Animals KW - Tumor Cells, Cultured KW - Epithelial Cells KW - Humans KW - Cell Division -- drug effects KW - Growth Substances -- blood KW - Bronchial Neoplasms -- genetics KW - Mice KW - Gene Expression Regulation KW - Transforming Growth Factors -- pharmacology KW - Bronchial Neoplasms -- pathology KW - Genes, ras KW - Cell Transformation, Neoplastic -- pathology KW - Bronchi -- cytology KW - Neoplasms, Experimental -- genetics KW - Neoplasms, Experimental -- pathology KW - Cell Differentiation -- drug effects KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78679115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene+research&rft.atitle=Human+bronchial+epithelial+cells+neoplastically+transformed+by+v-Ki-ras%3A+altered+response+to+inducers+of+terminal+squamous+differentiation.&rft.au=Reddel%2C+R+R%3BKe%2C+Y%3BKaighn%2C+M+E%3BMalan-Shibley%2C+L%3BLechner%2C+J+F%3BRhim%2C+J+S%3BHarris%2C+C+C&rft.aulast=Reddel&rft.aufirst=R&rft.date=1988-01-01&rft.volume=3&rft.issue=4&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=Oncogene+research&rft.issn=08906467&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-29 N1 - Date created - 1989-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Negative regulation of c-myc transcription involves myc family proteins. AN - 78679052; 2976141 AB - Expression of the c-myc gene is suppressed in NIH 3T3 mouse fibroblast cells infected with recombinant retroviruses expressing high levels of v-myc (10-fold greater than those of c-myc). Suppression of steady state levels of c-myc mRNA occurred at least in part at the level of transcription from c-myc promoters P1 and P2, and involved v-myc protein since cells infected with constructs containing frameshifts and deletions in v-myc had normal levels of c-myc mRNA and protein. Suppression of c-myc expression was also observed in fibroblasts transfected with a N-myc expression vector and in fibroblasts infected with a c-myc retrovirus. These findings establish that v-myc protein is involved either directly or indirectly in a regulatory circuit which represses c-myc proto-oncogene transcription. Feedback regulation of c-myc transcription may be relevant in establishing the lineage specific expression of myc family proto-oncogenes. Reduced steady state levels of c-myc mRNA were also observed in NIH 3T3 cells infected with 12S and 13S EIA recombinant retroviruses suggesting that the exogenous oncogene of adenovirus, EIA, can alleviate the requirement of myc for cell growth and may also share transcriptional target genes. JF - Oncogene research AU - Cleveland, J L AU - Huleihel, M AU - Bressler, P AU - Siebenlist, U AU - Akiyama, L AU - Eisenman, R N AU - Rapp, U R AD - Laboratory of Viral Carcinogenesis, National Cancer Institute, FCRF, Frederick, Maryland 21701. Y1 - 1988 PY - 1988 DA - 1988 SP - 357 EP - 375 VL - 3 IS - 4 SN - 0890-6467, 0890-6467 KW - Adenovirus Early Proteins KW - 0 KW - Oncogene Proteins, Viral KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins c-myc KW - RNA, Messenger KW - Transcription Factors KW - Index Medicus KW - Animals KW - Blotting, Northern KW - DNA Mutational Analysis KW - Transcription, Genetic KW - Mice KW - RNA, Messenger -- genetics KW - Cell Line KW - Transcription Factors -- physiology KW - Oncogenes KW - Oncogene Proteins, Viral -- genetics KW - Oncogene Proteins, Viral -- physiology KW - Gene Expression Regulation KW - Proto-Oncogene Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78679052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene+research&rft.atitle=Negative+regulation+of+c-myc+transcription+involves+myc+family+proteins.&rft.au=Cleveland%2C+J+L%3BHuleihel%2C+M%3BBressler%2C+P%3BSiebenlist%2C+U%3BAkiyama%2C+L%3BEisenman%2C+R+N%3BRapp%2C+U+R&rft.aulast=Cleveland&rft.aufirst=J&rft.date=1988-01-01&rft.volume=3&rft.issue=4&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Oncogene+research&rft.issn=08906467&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-29 N1 - Date created - 1989-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The twin method in the study of vulnerability to drug abuse. AN - 78676590; 3147397 JF - NIDA research monograph AU - Pickens, R W AU - Svikis, D S AD - Division of Clinica Research, National Institute on Drug Abuse, Rockville, MD 20857. Y1 - 1988 PY - 1988 DA - 1988 SP - 41 EP - 51 VL - 89 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - Disease Susceptibility KW - Twins, Monozygotic KW - Humans KW - Adult KW - Twins, Dizygotic KW - Male KW - Female KW - Diseases in Twins KW - Alcoholism -- genetics KW - Substance-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78676590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=The+twin+method+in+the+study+of+vulnerability+to+drug+abuse.&rft.au=Pickens%2C+R+W%3BSvikis%2C+D+S&rft.aulast=Pickens&rft.aufirst=R&rft.date=1988-01-01&rft.volume=89&rft.issue=&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-31 N1 - Date created - 1989-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The use of second-order schedules to study the influence of environmental stimuli on drug-seeking behavior. AN - 78676300; 3147382 JF - NIDA research monograph AU - Schindler, C W AU - Katz, J L AU - Goldberg, S R AD - Preclinical Pharmacology Branch, National Institute on Drug Abuse, Baltimore, MD 21224. Y1 - 1988 PY - 1988 DA - 1988 SP - 180 EP - 195 VL - 84 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - Animals KW - Adaptation, Psychological KW - Humans KW - Disease Models, Animal KW - Substance-Related Disorders -- therapy KW - Conditioning (Psychology) KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78676300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=The+use+of+second-order+schedules+to+study+the+influence+of+environmental+stimuli+on+drug-seeking+behavior.&rft.au=Schindler%2C+C+W%3BKatz%2C+J+L%3BGoldberg%2C+S+R&rft.aulast=Schindler&rft.aufirst=C&rft.date=1988-01-01&rft.volume=84&rft.issue=&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-31 N1 - Date created - 1989-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Potential interactions between GABAb and cholinergic systems: baclofen augments scopolamine-induced performance deficits in the eight-arm radial maze. AN - 78672472; 3147471 AB - Sixteen male Fischer-344N rats were trained on a eight-arm radial maze task for food reinforcement. The effects of various doses of baclofen (1.25 or 2.50 mg/kg) and scopolamine (0.188, 0.375, and 0.750 mg/kg) were determined alone and in combination. Relative to vehicle controls, baclofen alone did not affect performance in the radial arm maze (number correct in the first eight responses, total errors) or the time required to complete the maze. Scopolamine alone decreased the number of correct responses in the first eight arm choices, while increasing both the number of errors and the time necessary to complete the maze. When the two drugs were co-administered, baclofen had no effect on the number of errors or time required to complete the maze in the presence of scopolamine; however, in combination with the high dose of scopolamine, it significantly increased the number of errors made during the first eight choices. Baclofen thus can exacerbate some radial arm maze dificits produced by an anticholinergic drug. In a subsequent experiment to test the interaction between scopolamine and baclofen using a nonlearned behavior, baclofen (1.25 and 2.5 mg/kg) did not affect motor activity, whereas all doses of scopolamine (0.188-0.75 mg/kg) increased activity. The higher dose of baclofen attenuated scopolamine-induced hypermotility by 50%, but the lower dose of baclofen was not effective. These data demonstrate pharmacological interactions between baclofen, a drug used clinically for spaticity, and a drug having anticholinergic properties. JF - Psychopharmacology AU - Sidel, E S AU - Tilson, H A AU - McLamb, R L AU - Wilson, W A AU - Swartzwelder, H S AD - Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 116 EP - 120 VL - 96 IS - 1 SN - 0033-3158, 0033-3158 KW - Scopolamine Hydrobromide KW - 451IFR0GXB KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Baclofen KW - H789N3FKE8 KW - Index Medicus KW - Rats KW - Conditioning, Operant -- drug effects KW - Animals KW - Rats, Inbred F344 KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Motor Activity -- drug effects KW - Male KW - Scopolamine Hydrobromide -- pharmacology KW - Psychomotor Performance -- drug effects KW - Parasympathetic Nervous System -- drug effects KW - gamma-Aminobutyric Acid -- physiology KW - Baclofen -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78672472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Potential+interactions+between+GABAb+and+cholinergic+systems%3A+baclofen+augments+scopolamine-induced+performance+deficits+in+the+eight-arm+radial+maze.&rft.au=Sidel%2C+E+S%3BTilson%2C+H+A%3BMcLamb%2C+R+L%3BWilson%2C+W+A%3BSwartzwelder%2C+H+S&rft.aulast=Sidel&rft.aufirst=E&rft.date=1988-01-01&rft.volume=96&rft.issue=1&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-05 N1 - Date created - 1989-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Rearing paradigm in a nonhuman primate affects response to beta-CCE challenge. AN - 78671805; 3147480 AB - Two groups of socially housed rhesus monkeys were raised under conditions differing in the degree of control or mastery over appetitive stimuli (food, water, and treats) in the 1st year of life. At age 18-24 months, a benzodiazepine receptor inverse agonist, beta-carboline-3-carboxylic acid ethyl ester (beta-CCE), was administered to both social groups to investigate the effects of differential rearing on the response to a putative anxiogenic drug. In both groups beta-CCE was followed by behavioral activation with a profile suggesting increases in aggression rather than fear or anxiety. A group by drug analysis revealed that the increase in aggression was observed predominantly in the subjects reared with mastery during the 1st year. Plasma cortisol increased in both groups, but its increase was greater in the yoked subjects. These results suggest that early experience with controllability may have long term consequences which can be revealed by challenge with beta-CCE. JF - Psychopharmacology AU - Insel, T R AU - Scanlan, J AU - Champoux, M AU - Suomi, S J AD - Laboratory of Clinical Science, NIMH, Poolesville, MD 20837. Y1 - 1988 PY - 1988 DA - 1988 SP - 81 EP - 86 VL - 96 IS - 1 SN - 0033-3158, 0033-3158 KW - Carbolines KW - 0 KW - beta-carboline-3-carboxylic acid ethyl ester KW - 74214-62-3 KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Aggression -- drug effects KW - Drug Interactions KW - Reinforcement Schedule KW - Fear -- drug effects KW - Motor Activity -- drug effects KW - Macaca mulatta KW - Male KW - Hydrocortisone -- blood KW - Female KW - Behavior, Animal -- drug effects KW - Carbolines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78671805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Rearing+paradigm+in+a+nonhuman+primate+affects+response+to+beta-CCE+challenge.&rft.au=Insel%2C+T+R%3BScanlan%2C+J%3BChampoux%2C+M%3BSuomi%2C+S+J&rft.aulast=Insel&rft.aufirst=T&rft.date=1988-01-01&rft.volume=96&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-05 N1 - Date created - 1989-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The use of oligonucleotide-directed mutagenesis to probe molecular mechanisms of mutagenesis. AN - 78670876; 3226920 JF - Nucleic acids symposium series AU - Kunkel, T A AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 43 IS - 19 SN - 0261-3166, 0261-3166 KW - Oligonucleotide Probes KW - 0 KW - Index Medicus KW - Genetic Engineering -- methods KW - Mutation KW - DNA Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78670876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+symposium+series&rft.atitle=The+use+of+oligonucleotide-directed+mutagenesis+to+probe+molecular+mechanisms+of+mutagenesis.&rft.au=Kunkel%2C+T+A&rft.aulast=Kunkel&rft.aufirst=T&rft.date=1988-01-01&rft.volume=&rft.issue=19&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+symposium+series&rft.issn=02613166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-29 N1 - Date created - 1989-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Genetic vulnerability to drug abuse. AN - 78667500; 3147389 JF - NIDA research monograph AU - Pickens, R W AU - Svikis, D S AD - Division of Clinical Research, National Institute on Drug Abuse, Rockville, MD 20857. Y1 - 1988 PY - 1988 DA - 1988 SP - 1 EP - 8 VL - 89 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - Disease Susceptibility KW - Humans KW - Substance-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78667500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Genetic+vulnerability+to+drug+abuse.&rft.au=Pickens%2C+R+W%3BSvikis%2C+D+S&rft.aulast=Pickens&rft.aufirst=R&rft.date=1988-01-01&rft.volume=89&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-31 N1 - Date created - 1989-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Current approaches to the adoptive immunotherapy of cancer. AN - 78666972; 3265581 AB - Interleukin 2 has provided the means of generating activated lymphocytes from the tumor-bearing host which show in vitro anti-tumor activity. These cells can be derived either from a ubiquitous null cell precursor population, exhibiting promiscuous lysis of nearly all tumors after culture in IL2 (ie. the LAK cell) or from a T cell precursor population infiltrating tumors and showing some relative specificity for lysis of the autologous tumor following activation (ie. TIL). When utilized in murine cellular adoptive immunotherapy models, both LAK cells and TIL are able to display marked anti-tumor effects against established micrometastatic tumor. LAK cells have been subsequently employed in adoptive immunotherapy against metastatic human tumors and in a limited number of cases have been able to mediate the regression of advanced cancers of differing histologies. The role of adoptive immunotherapy as standard therapy of human tumors will depend on refinement of the methodology and progress toward increased efficacy and reduced toxicity. TIL may possess theoretical advantages in these areas and efforts are currently proceeding to evaluate these new anti-tumor reagents in the the treatment of patients with cancer. JF - Advances in experimental medicine and biology AU - Yang, J C AU - Rosenberg, S A AD - Surgery Branch, National Cancer Institute Bethesda, Md. Y1 - 1988 PY - 1988 DA - 1988 SP - 459 EP - 467 VL - 233 SN - 0065-2598, 0065-2598 KW - Interleukin-2 KW - 0 KW - Index Medicus KW - Lymphocyte Activation KW - Cytotoxicity, Immunologic KW - Animals KW - Liver Neoplasms -- therapy KW - Lung Neoplasms -- secondary KW - Humans KW - Neoplasm Metastasis KW - Lung Neoplasms -- therapy KW - Mice KW - Liver Neoplasms -- secondary KW - Neoplasms, Experimental -- immunology KW - Neoplasms, Experimental -- therapy KW - Interleukin-2 -- therapeutic use KW - Immunization, Passive KW - Neoplasms, Experimental -- pathology KW - Melanoma -- immunology KW - Killer Cells, Natural -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78666972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=Current+approaches+to+the+adoptive+immunotherapy+of+cancer.&rft.au=Yang%2C+J+C%3BRosenberg%2C+S+A&rft.aulast=Yang&rft.aufirst=J&rft.date=1988-01-01&rft.volume=233&rft.issue=&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-22 N1 - Date created - 1989-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The measurement of D,L-2,3-butanediol in controls and patients with alcoholic cirrhosis. AN - 78666448; 3223433 AB - Plasma D,L-2,3-butanediol was measured in 53 controls and 50 patients with alcoholic cirrhosis, none of whom had measurable amounts of blood ethanol. Thirteen of 50 samples from patients with alcoholic cirrhosis had measurable D,L-2,3-butanediol. (range less than 5-154 microM). In one patient with alcoholic cirrhosis who had been abstinent from ethanol for over 5 years plasma levels of D,L-2,3-butanediol ranged between 154 and 211 microM over a one-year period. Only one of the 53 control subjects had detectable levels of D,L-2,3-butanediol. Although it has previously been reported that 2,3-butanediol is present in alcoholics consuming distilled spirits (Rutstein et al. (1983) Lancet ii, 534), this is the first report of the persistent presence of these compounds in alcoholics in the absence of ethanol. Clearly in abstinent alcoholics the presence of 2,3-butanediol is not due to the ingestion of undistilled spirits nor is it likely to arise directly from the metabolic products of ethanol. The presence of D,L-2,3-butanediol in patients with alcoholic cirrhosis and its absence in control subjects suggests that this compound may be a marker of some forms for alcoholism. JF - Advances in alcohol & substance abuse AU - Casazza, J P AU - Freitas, J AU - Stambuk, D AU - Morgan, M Y AU - Veech, R L AD - Laboratory of Metabolism and Molecular Biology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852. Y1 - 1988 PY - 1988 DA - 1988 SP - 33 EP - 35 VL - 7 IS - 3-4 SN - 0270-3106, 0270-3106 KW - Biomarkers KW - 0 KW - Butylene Glycols KW - 2,3-butylene glycol KW - 45427ZB5IJ KW - Index Medicus KW - Humans KW - Butylene Glycols -- blood KW - Liver Cirrhosis, Alcoholic -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78666448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=The+measurement+of+D%2CL-2%2C3-butanediol+in+controls+and+patients+with+alcoholic+cirrhosis.&rft.au=Casazza%2C+J+P%3BFreitas%2C+J%3BStambuk%2C+D%3BMorgan%2C+M+Y%3BVeech%2C+R+L&rft.aulast=Casazza&rft.aufirst=J&rft.date=1988-01-01&rft.volume=7&rft.issue=3-4&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acute effects of ethanol on motor performance and movement-related brain potentials. AN - 78666134; 3223435 AB - The acute effects of ethanol on skilled motor functions were examined in male social drinkers, under four doses ranging from 0 (placebo) to 1.05 g/kg lean body weight. The movement entailed a forewarned choice transitive motion of the arm and hand, aimed at a flanking target. Performance measures disclosed only small effects of ethanol on speed and accuracy of movement. The simultaneously-recorded movement-related brain potentials disclosed decreased involvement of frontal and posterior brain areas, suggesting that ethanol disrupted the planning and regulation of movement despite the overall preservation of reaction speed. JF - Advances in alcohol & substance abuse AU - Rohrbaugh, J W AU - Stapleton, J M AU - Frowein, H W AU - Adinoff, B AU - Varner, J L AU - Lane, E A AU - Eckardt, M J AU - Linnoila, M AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 53 EP - 57 VL - 7 IS - 3-4 SN - 0270-3106, 0270-3106 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Reaction Time -- drug effects KW - Humans KW - Male KW - Movement -- drug effects KW - Ethanol -- adverse effects KW - Psychomotor Performance -- drug effects KW - Electrophysiology -- drug effects KW - Contingent Negative Variation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78666134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=Acute+effects+of+ethanol+on+motor+performance+and+movement-related+brain+potentials.&rft.au=Rohrbaugh%2C+J+W%3BStapleton%2C+J+M%3BFrowein%2C+H+W%3BAdinoff%2C+B%3BVarner%2C+J+L%3BLane%2C+E+A%3BEckardt%2C+M+J%3BLinnoila%2C+M&rft.aulast=Rohrbaugh&rft.aufirst=J&rft.date=1988-01-01&rft.volume=7&rft.issue=3-4&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of alcoholic organic brain syndrome with the serotonin reuptake inhibitor fluvoxamine: a preliminary study. AN - 78666007; 2464912 AB - The chronic effects of fluvoxamine (200 mg per day for 4 weeks) were studied in ten alcoholic organic brain syndrome patients in a double-blind cross-over design. Complete neuropsychological evaluation was performed as well as measurement of neurochemical changes in CSF. Fluvoxamine produced a small but significant improvement in memory performance. An analysis of fluvoxamine minus placebo difference scores showed a significant correlation between memory functioning and CSF 5HIAA levels. Alcohol amnestic syndrome patients who had the highest blood levels of fluvoxamine demonstrated the largest changes in CSF 5HIAA and improvement in memory performance under fluvoxamine. These findings implicate a role of serotonergic mechanisms in alcoholic organic brain syndrome and suggest that with individual titration of the drug dose, fluvoxamine might be a clinically useful agent in the treatment of this syndrome. JF - Advances in alcohol & substance abuse AU - Stapleton, J M AU - Eckardt, M J AU - Martin, P AU - Adinoff, B AU - Roehrich, L AU - Bone, G AU - Rubinow, D AU - Linnoila, M AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 47 EP - 51 VL - 7 IS - 3-4 SN - 0270-3106, 0270-3106 KW - Oximes KW - 0 KW - Ethanol KW - 3K9958V90M KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Fluvoxamine KW - O4L1XPO44W KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Hydroxyindoleacetic Acid -- cerebrospinal fluid KW - Aged KW - Middle Aged KW - Dementia -- chemically induced KW - Dementia -- drug therapy KW - Alcohol Amnestic Disorder -- drug therapy KW - Ethanol -- adverse effects KW - Substance-Related Disorders -- drug therapy KW - Oximes -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78666007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=Treatment+of+alcoholic+organic+brain+syndrome+with+the+serotonin+reuptake+inhibitor+fluvoxamine%3A+a+preliminary+study.&rft.au=Stapleton%2C+J+M%3BEckardt%2C+M+J%3BMartin%2C+P%3BAdinoff%2C+B%3BRoehrich%2C+L%3BBone%2C+G%3BRubinow%2C+D%3BLinnoila%2C+M&rft.aulast=Stapleton&rft.aufirst=J&rft.date=1988-01-01&rft.volume=7&rft.issue=3-4&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Circadian rhythms of cortisol during alcohol withdrawal. AN - 78665951; 3223434 AB - The authors have investigated the function of the hypothalamic-pituitary-adrenocortical (HPA) axis during and after withdrawal from alcohol. 24 hour rhythms of cortisol were abnormal in that elevated levels were seen throughout the day in patients with moderate to severe, but not mild, withdrawal. This abnormality of circadian secretion of cortisol, which is similar to that seen in Cushing's syndrome and post-operative trauma, returned to normal after a period of one week of abstinence on their in-patient ward. Such excessive secretion of cortisol may explain some of the complications of chronic alcoholism. JF - Advances in alcohol & substance abuse AU - Risher-Flowers, D AU - Adinoff, B AU - Ravitz, B AU - Bone, G H AU - Martin, P R AU - Nutt, D AU - Linnoila, M AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 37 EP - 41 VL - 7 IS - 3-4 SN - 0270-3106, 0270-3106 KW - Ethanol KW - 3K9958V90M KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Time Factors KW - Male KW - Ethanol -- adverse effects KW - Circadian Rhythm KW - Substance Withdrawal Syndrome -- blood KW - Hydrocortisone -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78665951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=Circadian+rhythms+of+cortisol+during+alcohol+withdrawal.&rft.au=Risher-Flowers%2C+D%3BAdinoff%2C+B%3BRavitz%2C+B%3BBone%2C+G+H%3BMartin%2C+P+R%3BNutt%2C+D%3BLinnoila%2C+M&rft.aulast=Risher-Flowers&rft.aufirst=D&rft.date=1988-01-01&rft.volume=7&rft.issue=3-4&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - RO 15-4513 and its interaction with ethanol. AN - 78664328; 2851930 AB - It has recently been claimed that RO 15-4513 selectively opposes some of the behavioral actions of ethanol. Our studies on the intrinsic effects of this compound have shown it to be proconvulsant and to reduce exploratory behavior in mice. In these respects RO 15-4513 resembles a benzodiazepine receptor partial inverse agonist. Such intrinsic actions may well explain its alcohol-antagonizing properties, and argue against its potential in humans. In addition to partially reversing the effects of ethanol, RO 15-4513 also partially reverses the behavioral effect of a barbiturate and completely reverses the effects of a benzodiazepine. JF - Advances in alcohol & substance abuse AU - Lister, R G AU - Nutt, D J AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 119 EP - 123 VL - 7 IS - 3-4 SN - 0270-3106, 0270-3106 KW - Azides KW - 0 KW - Receptors, GABA-A KW - Benzodiazepines KW - 12794-10-4 KW - Ethanol KW - 3K9958V90M KW - Ro 15-4513 KW - 91917-65-6 KW - Pentobarbital KW - I4744080IR KW - Index Medicus KW - Rats KW - Saimiri KW - Animals KW - Drug Interactions KW - Receptors, GABA-A -- drug effects KW - Mice KW - Pentobarbital -- pharmacology KW - Benzodiazepines -- antagonists & inhibitors KW - Ethanol -- pharmacology KW - Azides -- pharmacology KW - Benzodiazepines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78664328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=RO+15-4513+and+its+interaction+with+ethanol.&rft.au=Lister%2C+R+G%3BNutt%2C+D+J&rft.aulast=Lister&rft.aufirst=R&rft.date=1988-01-01&rft.volume=7&rft.issue=3-4&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - GC/MS assay of prostaglandins in cerebrospinal fluid from humans and monkeys. AN - 78664245; 3223427 AB - The objective of this project has been to develop a sensitive and specific assay for prostaglandins in human cerebrospinal fluid (CSF) from patients with alcoholism and appropriate controls using gas chromatography/mass spectrometry. This study was initiated because numerous literature reports strongly suggest that a relationship exists between ethanol's central nervous system effects and the central production of prostaglandins. In both human and animal studies, administration of prostaglandin synthesis inhibitors prior to administration of ethanol attenuated central nervous system effects of ethanol. Samples from alcoholics after a three week period of abstinence and normals contained none of the measured prostaglandins (PGE2, PGE1, PGF1a, PGF2a, 6-keto-PGF1a) at a concentration more than twice the limit of quantification (3 pg/mL CSF). Comparison of GC/MS and radioimmunoassay methods provided further validation for these results. Literature reports of much higher levels of prostaglandins in normal controls, i.e., tens to hundreds of pg/mL CSF, appear to be incorrect. Examination of monkey CSF provided a positive control, since several of the prostaglandins were easily quantifiable in these samples. JF - Advances in alcohol & substance abuse AU - Yergey, J A AU - Salem, N AU - Karanian, J W AU - Linnoila, M AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 125 EP - 129 VL - 7 IS - 3-4 SN - 0270-3106, 0270-3106 KW - Prostaglandins KW - 0 KW - 6-Ketoprostaglandin F1 alpha KW - 58962-34-8 KW - Dinoprost KW - B7IN85G1HY KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Animals KW - Humans KW - Dinoprostone -- cerebrospinal fluid KW - Gas Chromatography-Mass Spectrometry KW - 6-Ketoprostaglandin F1 alpha -- cerebrospinal fluid KW - Macaca mulatta KW - Dinoprost -- cerebrospinal fluid KW - Radioimmunoassay KW - Prostaglandins -- cerebrospinal fluid KW - Alcoholism -- cerebrospinal fluid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78664245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=GC%2FMS+assay+of+prostaglandins+in+cerebrospinal+fluid+from+humans+and+monkeys.&rft.au=Yergey%2C+J+A%3BSalem%2C+N%3BKaranian%2C+J+W%3BLinnoila%2C+M&rft.aulast=Yergey&rft.aufirst=J&rft.date=1988-01-01&rft.volume=7&rft.issue=3-4&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alpha-2-adrenoceptor function in alcoholics. AN - 78664153; 2851932 AB - Alpha-2-adrenoceptor function has been assessed using the iv clonidine challenge test. During withdrawal clonidine effects on blood pressure, sedation and body temperature were blunted compared with the abstinent state and healthy controls. In contrast the growth hormone response was blunted in both the withdrawing and abstinent alcoholics. These findings suggest that a deficit of alpha-2-inhibitory control is a feature of withdrawal and, in the case of the endocrine response, may persist for some time. JF - Advances in alcohol & substance abuse AU - Nutt, D J AU - Glue, P AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 43 EP - 46 VL - 7 IS - 3-4 SN - 0270-3106, 0270-3106 KW - Receptors, Adrenergic, alpha KW - 0 KW - Ethanol KW - 3K9958V90M KW - Growth Hormone KW - 9002-72-6 KW - Clonidine KW - MN3L5RMN02 KW - Index Medicus KW - Body Temperature -- drug effects KW - Growth Hormone -- physiology KW - Humans KW - Blood Pressure -- drug effects KW - Ethanol -- adverse effects KW - Substance Withdrawal Syndrome -- physiopathology KW - Receptors, Adrenergic, alpha -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78664153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=Alpha-2-adrenoceptor+function+in+alcoholics.&rft.au=Nutt%2C+D+J%3BGlue%2C+P&rft.aulast=Nutt&rft.aufirst=D&rft.date=1988-01-01&rft.volume=7&rft.issue=3-4&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neurotransmitters and alcoholism: methodological issues. AN - 78664052; 2464911 AB - This short review examines recent findings on neurochemical differences between alcoholics and various control populations. Particular emphasis is given to clinical variables which affect concentrations of neurotransmitter metabolites in the cerebrospinal fluid, and which have to be controlled in order to make meaningful comparisons between various diagnostic groups. The review focuses on two of the major monoamine transmitters, serotonin and norepinephrine, and excludes neurotransmitters and modulators such as dopamine, acetylcholine, peptides, prostaglandins, amino acids and purines, since their significance to alcoholism is currently less well understood. JF - Advances in alcohol & substance abuse AU - Linnoila, M AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 17 EP - 24 VL - 7 IS - 3-4 SN - 0270-3106, 0270-3106 KW - Serotonin KW - 333DO1RDJY KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Humans KW - Hydroxyindoleacetic Acid -- cerebrospinal fluid KW - Norepinephrine -- physiology KW - Serotonin -- physiology KW - Alcoholism -- physiopathology KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78664052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=Neurotransmitters+and+alcoholism%3A+methodological+issues.&rft.au=Linnoila%2C+M&rft.aulast=Linnoila&rft.aufirst=M&rft.date=1988-01-01&rft.volume=7&rft.issue=3-4&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Brain imaging in alcoholic patients. AN - 78663504; 3066195 AB - Imaging in vivo aspects of brain structure and function hold great promise for the study of alcoholism. Computerized axial tomography and magnetic resonance imaging have been used successfully to demonstrate structural abnormalities in alcoholic patients. Positron emission tomography and topographic images of electrical and magnetic activity are useful measures of brain function that could be applied more rigorously to the study of alcoholism. Interrelating various types of imaging data is an important area that is still in the developmental stage. JF - Advances in alcohol & substance abuse AU - Eckardt, M J AU - Rohrbaugh, J W AU - Rio, D AU - Rawlings, R R AU - Coppola, R AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 59 EP - 71 VL - 7 IS - 3-4 SN - 0270-3106, 0270-3106 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Magnetoencephalography KW - Humans KW - Electroencephalography KW - Tomography, X-Ray Computed KW - Tomography, Emission-Computed KW - Cerebrovascular Circulation KW - Alcoholism -- diagnosis KW - Brain -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78663504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=Brain+imaging+in+alcoholic+patients.&rft.au=Eckardt%2C+M+J%3BRohrbaugh%2C+J+W%3BRio%2C+D%3BRawlings%2C+R+R%3BCoppola%2C+R&rft.aulast=Eckardt&rft.aufirst=M&rft.date=1988-01-01&rft.volume=7&rft.issue=3-4&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The aminopyrine breath test for the evaluation of liver function in alcoholic patients: drug pharmacokinetics and environmental factors. AN - 78663440; 3146921 AB - Drug pharmacokinetics and environmental factors contribute to the selection of an ideal drug substrate for the determination of liver function via the carbon dioxide breath test. An ideal drug should be rapidly absorbed, and have an hepatic extraction ratio between 0.2 and 0.5. Its metabolism should not be induced by ethanol or be affected by cigarette smoking. The relative promise of caffeine and methacetin are compared to aminopyrine. JF - Advances in alcohol & substance abuse AU - Lane, E A AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 25 EP - 32 VL - 7 IS - 3-4 SN - 0270-3106, 0270-3106 KW - Acetamides KW - 0 KW - Aminopyrine KW - 01704YP3MO KW - methacetin KW - 13E468TFHP KW - Carbon Dioxide KW - 142M471B3J KW - Caffeine KW - 3G6A5W338E KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Smoking -- physiopathology KW - Carbon Dioxide -- analysis KW - Caffeine -- pharmacokinetics KW - Ethanol -- pharmacology KW - Humans KW - Acetamides -- pharmacokinetics KW - Aminopyrine -- pharmacokinetics KW - Liver Function Tests KW - Liver Diseases, Alcoholic -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78663440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=The+aminopyrine+breath+test+for+the+evaluation+of+liver+function+in+alcoholic+patients%3A+drug+pharmacokinetics+and+environmental+factors.&rft.au=Lane%2C+E+A&rft.aulast=Lane&rft.aufirst=E&rft.date=1988-01-01&rft.volume=7&rft.issue=3-4&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interactions of 5HT reuptake inhibitors and ethanol in tests of exploration and anxiety. AN - 78663375; 3146920 AB - Treatment with 5HT reuptake inhibitors has been shown to attenuate ethanol consumption in both animals and humans. These experiments investigate in mice the interactions of the 5HT reuptake inhibitors fluoxetine, citalopram and fluvoxamine and the NA uptake inhibitor desipramine with ethanol in the holeboard test and the elevated plusmaze test of anxiety. Ethanol (2.4 g/kg) increased activity both in the holeboard and on the plusmaze, decreased both the number and duration of head-dips in the holeboard, and increased both the percentage time and percentage entries on to the open-arm of the plusmaze (reflecting its anxiolytic properties). On their own, the selective 5HT uptake inhibitors fluoxetine, fluvoxamine, and citalopram and the NA uptake inhibitor desipramine (10-20 mg/kg) did not significantly alter any of the behavioral measures. The only consistent interaction was seen with fluoxetine which reduced ethanol's anxiolytic effects at the 20 mg/kg dose without altering ethanol's effects on exploration or locomotion. The results suggest that the attenuation of ethanol's anxiolytic properties by fluoxetine may not be serotonin related since other 5HT reuptake inhibitors did not show this effect at the doses used. JF - Advances in alcohol & substance abuse AU - Durcan, M J AU - Lister, R G AU - Eckardt, M J AU - Linnoila, M AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 113 EP - 117 VL - 7 IS - 3-4 SN - 0270-3106, 0270-3106 KW - Oximes KW - 0 KW - Serotonin Antagonists KW - Fluoxetine KW - 01K63SUP8D KW - Citalopram KW - 0DHU5B8D6V KW - Ethanol KW - 3K9958V90M KW - Fluvoxamine KW - O4L1XPO44W KW - Desipramine KW - TG537D343B KW - Index Medicus KW - Oximes -- pharmacology KW - Mice, Inbred Strains KW - Animals KW - Fluoxetine -- pharmacology KW - Drug Interactions KW - Desipramine -- pharmacology KW - Exploratory Behavior -- drug effects KW - Citalopram -- pharmacology KW - Anxiety -- physiopathology KW - Motor Activity -- drug effects KW - Mice KW - Serotonin Antagonists -- pharmacology KW - Ethanol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78663375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=Interactions+of+5HT+reuptake+inhibitors+and+ethanol+in+tests+of+exploration+and+anxiety.&rft.au=Durcan%2C+M+J%3BLister%2C+R+G%3BEckardt%2C+M+J%3BLinnoila%2C+M&rft.aulast=Durcan&rft.aufirst=M&rft.date=1988-01-01&rft.volume=7&rft.issue=3-4&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of chronic ethanol ingestion on mouse brain beta-adrenergic receptors (BAR) and adenylate cyclase. AN - 78663090; 2851934 AB - Previous work showed that chronic ethanol ingestion by C57BL mice resulted in reduced stimulation of cerebral cortical adenylate cyclase (AC) activity by isoproterenol (ISO) and guanine nucleotides (GN). To investigate the mechanism of this change we have assessed the effect of chronic ethanol ingestion on agonist and antagonist binding to BAR in cerebral cortex (mainly beta 1-AR) and cerebellum (mainly beta 2-AR). C57BL mice were fed ethanol in a liquid diet for seven days and were withdrawn for various intervals. Agonist (ISO) binding data were best fit by a two-site model (high and low affinity states) in cortical membranes of control mice. GN induced conversion to a one site model (low affinity state). At the time of withdrawal, ISO binding data in cortical membranes were best fit by a one-site model even in the absence of GN. Antagonist binding was not affected. These results resemble those seen after heterologous desensitization, indicating "uncoupling" of receptor and AC. Control cerebellar ISO binding data were similar to cortical data. Chronic ethanol ingestion, however, did not produce data fit by a one site model in cerebellum. The affinity for ISO of the high affinity state of the BAR was significantly decreased at the time of withdrawal. ISO-stimulated AC-activity in cerebellar membranes was not affected by chronic ethanol ingestion, indicating that, in contrast to cerebral cortex, the cerebellar BAR was not uncoupled from AC. JF - Advances in alcohol & substance abuse AU - Valverius, P AU - Hoffman, P L AU - Tabakoff, B AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852. Y1 - 1988 PY - 1988 DA - 1988 SP - 99 EP - 101 VL - 7 IS - 3-4 SN - 0270-3106, 0270-3106 KW - Guanine Nucleotides KW - 0 KW - Receptors, Adrenergic, beta KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Isoproterenol KW - L628TT009W KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Mice KW - Guanine Nucleotides -- pharmacology KW - Isoproterenol -- pharmacology KW - Receptors, Adrenergic, beta -- metabolism KW - Cerebral Cortex -- metabolism KW - Adenylyl Cyclases -- metabolism KW - Alcoholism -- metabolism KW - Cerebellum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78663090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=Effects+of+chronic+ethanol+ingestion+on+mouse+brain+beta-adrenergic+receptors+%28BAR%29+and+adenylate+cyclase.&rft.au=Valverius%2C+P%3BHoffman%2C+P+L%3BTabakoff%2C+B&rft.aulast=Valverius&rft.aufirst=P&rft.date=1988-01-01&rft.volume=7&rft.issue=3-4&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Study design in chronic lymphocytic leukemia. AN - 78662857; 3065736 AB - Recent enthusiasm for clinical trials in chronic lymphocytic leukemia (CLL) has resulted from both an increase in our understanding of the biology of CLL, and the availability of new and active cytotoxic drugs (e.g. 2'-deoxycoformycin [DCF]; fludarabine monophosphate [FAMP]) and the development of interesting biologic agents (e.g. IL-2). To best identify regimens worth pursuing in large scale clinical trials, uniform eligibility, response and toxicity criteria are essential. Standardization will facilitate comparison of results, ensure homogeneity of patient groups on clinical trials, and minimize the arbitrary nature of dose modifications. In 1987, an NCI-sponsored Working Group (NCI-WG) developed Guidelines for US clinical trials for CLL which included specific eligibility, response and toxicity criteria. These will be modified over time as more is learned about the disease. Trials are currently restricted to patients with active B-CLL. Although complete and partial response are carefully defined, alternative systems (e.g. stage shift for partial response) may be tested concurrently and definitions revised if warranted. Similarly, use of the modified Rai staging is encouraged, although other systems may also be studied and compared for clinical relevance. The U.S. Cooperative Oncology Groups and Cancer Centers are participating in a National CLL treatment program following the NCI-WG Guidelines. Phase I and II pilot trials of DCF and FAMP combined with each other or with conventional agents (e.g. FAMP + chlorambucil [CLB] + prednisone [P]; DCF + CLB + P; FAMP + P) are being conducted in previously treated patients. A collaborative phase III trial will compared the most promising regimens with "standard" chemotherapy in untreated patients.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Nouvelle revue francaise d'hematologie AU - Cheson, B D AD - Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 407 EP - 410 VL - 30 IS - 5-6 KW - Index Medicus KW - United States KW - Humans KW - National Institutes of Health (U.S.) KW - Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy KW - Clinical Trials as Topic -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78662857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nouvelle+revue+francaise+d%27hematologie&rft.atitle=Study+design+in+chronic+lymphocytic+leukemia.&rft.au=Cheson%2C+B+D&rft.aulast=Cheson&rft.aufirst=B&rft.date=1988-01-01&rft.volume=30&rft.issue=5-6&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Nouvelle+revue+francaise+d%27hematologie&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-16 N1 - Date created - 1989-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Adoptive immunotherapy: novel applications of blood cell separators. AN - 78656291; 3065331 AB - Animal models have demonstrated that syngeneic lymphocytes activated ex vivo and infused into animals with experimentally induced tumors can mediate tumor regression. This "adoptive immunotherapy" has been applied to patients with end-stage malignancy refractory to standard therapy. Lymphocytes are collected with the blood cell separator, expanded in culture under the influence of cytokines such as interleukin-2 (IL-2), and reinfused into the patient under conditions similar to those used in the animal models. Studies from several centers using lymphokine-activated killer (LAK) cells, involving more than 300 patients, have shown an overall response rate of greater than 15% and a complete response rate of approximately 10%. Renal cell carcinoma, melanoma, and lymphoma appear to be the cell types that respond best to such therapy. Toxicity in these phase 1 studies has been substantial, related primarily to high doses of intravenous IL-2, and treatment-related deaths have been reported. Adoptive immunotherapy using lymphocytes derived from surgically excised tumors, tumor-infiltrating lymphocytes (TIL), is in the early stages of clinical trials, but this appears to offer a potentially more potent and specific approach than does LAK cell therapy. TIL have been shown to traffic to tumor sites and mediate tumor regression. The mechanisms of adoptive immunotherapy are poorly understood, but blood cell separators and storage technology are playing a critical role in the collection and processing of cells for these research applications. JF - Journal of clinical apheresis AU - Klein, H G AD - Department of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 198 EP - 202 VL - 4 IS - 4 SN - 0733-2459, 0733-2459 KW - Index Medicus KW - T-Lymphocytes, Cytotoxic -- transplantation KW - Killer Cells, Natural -- transplantation KW - Humans KW - Blood Component Removal -- methods KW - Immunization, Passive -- instrumentation KW - Cell Separation -- instrumentation KW - Immunization, Passive -- methods KW - Blood Component Removal -- instrumentation KW - Cell Separation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78656291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+apheresis&rft.atitle=Adoptive+immunotherapy%3A+novel+applications+of+blood+cell+separators.&rft.au=Klein%2C+H+G&rft.aulast=Klein&rft.aufirst=H&rft.date=1988-01-01&rft.volume=4&rft.issue=4&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+apheresis&rft.issn=07332459&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-14 N1 - Date created - 1989-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cholera toxin-induced ADP-ribosylation of a 46 kDa protein is decreased in brains of ethanol-fed mice. AN - 78654016; 3146919 AB - The acute in vitro effects of ethanol on cerebral cortical adenylate cyclase activity and beta-adrenergic receptor characteristics suggested a site of action of ethanol at Gs, the stimulatory guanine nucleotide binding protein. After chronic ethanol ingestion, the beta-adrenergic receptor appeared to be uncoupled (i.e., the form of the receptor with high affinity for agonist was undetectable), and stimulation of adenylate cyclase activity by isoproterenol or guanine nucleotides was reduced, suggesting an alteration in the properties of Gs. To further characterize this change, cholera and pertussis toxin-mediated 32P-ADP-ribosylation of mouse cortical membranes was assessed in mice that had chronically ingested ethanol in a liquid diet. 32P-labeled proteins were separated by SDS-PAGE and quantitated by autoradiography. There was a selective 30-50% decrease in cholera toxin-induced labeling of 46 kDa protein band in membranes of ethanol-fed mice, with no apparent change in pertussis toxin-induced labeling. The 46 kDa protein has a molecular weight similar to that of the alpha subunit of Gs, suggesting a reduced amount of this protein or a change in its characteristics as a substrate for cholera toxin-induced ADP-ribosylation in cortical membranes of ethanol-fed mice. JF - Advances in alcohol & substance abuse AU - Nhamburo, P T AU - Hoffman, P L AU - Tabakoff, B AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852. Y1 - 1988 PY - 1988 DA - 1988 SP - 103 EP - 105 VL - 7 IS - 3-4 SN - 0270-3106, 0270-3106 KW - Adenylate Cyclase Toxin KW - 0 KW - Phosphorus Radioisotopes KW - Virulence Factors, Bordetella KW - Ethanol KW - 3K9958V90M KW - Adenosine Diphosphate KW - 61D2G4IYVH KW - Cholera Toxin KW - 9012-63-9 KW - Pertussis Toxin KW - EC 2.4.2.31 KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Index Medicus KW - Virulence Factors, Bordetella -- pharmacology KW - Animals KW - GTP-Binding Proteins -- metabolism KW - Mice, Inbred C57BL KW - Cholera Toxin -- pharmacology KW - Mice KW - Cerebral Cortex -- metabolism KW - Ethanol -- pharmacology KW - Adenosine Diphosphate -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78654016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=Cholera+toxin-induced+ADP-ribosylation+of+a+46+kDa+protein+is+decreased+in+brains+of+ethanol-fed+mice.&rft.au=Nhamburo%2C+P+T%3BHoffman%2C+P+L%3BTabakoff%2C+B&rft.aulast=Nhamburo&rft.aufirst=P&rft.date=1988-01-01&rft.volume=7&rft.issue=3-4&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The acquired immunodeficiency syndrome and intravenous drug abuse. AN - 78642043; 3064841 AB - Intravenous drug abusers constitute 25 per cent of the cases of the acquired immunodeficiency syndrome (AIDS) in adults in the United States of America and 21 per cent of such cases in Europe. The potential for the rapid spread of the human immunodeficiency virus (HIV) among intravenous drug abusers exists because such drug abusers commonly share drug injection equipment. The heterosexual and perinatal spread of AIDS is also largely associated with intravenous drug abusers, and drug abusers have been identified as a major vector for the spread of the AIDS epidemic as it is associated with intravenous drug abuse. As long as intravenous drug abusers are addicted, they will continue to be at risk of contracting AIDS. Thus, the primary AIDS prevention strategy must be to help addicts to stop using drugs. It is suggested that drug abuse treatment resources should be expanded and outreach programmes developed to encourage more intravenous drug abusers to enter treatment. AIDS risk-reduction counseling must also be provided to intravenous drug abusers who continue injecting drugs, and to addicts and their sexual partners to prevent the sexual spread of HIV. Vigorous AIDS prevention initiatives must be undertaken now, using the most promising intervention strategies, while simultaneously evaluating and refining these strategies. JF - Bulletin on narcotics AU - Battjes, R J AU - Leukefeld, C G AU - Pickens, R W AU - Haverkos, H W AD - National Institute on Drug Abuse, Rockville, Maryland. Y1 - 1988 PY - 1988 DA - 1988 SP - 21 EP - 34 VL - 40 IS - 1 SN - 0007-523X, 0007-523X KW - Street Drugs KW - 0 KW - Index Medicus KW - AIDS/HIV KW - HIV Seropositivity KW - Risk Factors KW - Humans KW - Male KW - Female KW - Injections, Intravenous -- instrumentation KW - Acquired Immunodeficiency Syndrome -- prevention & control KW - Substance-Related Disorders -- therapy KW - Acquired Immunodeficiency Syndrome -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78642043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+on+narcotics&rft.atitle=The+acquired+immunodeficiency+syndrome+and+intravenous+drug+abuse.&rft.au=Battjes%2C+R+J%3BLeukefeld%2C+C+G%3BPickens%2C+R+W%3BHaverkos%2C+H+W&rft.aulast=Battjes&rft.aufirst=R&rft.date=1988-01-01&rft.volume=40&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Bulletin+on+narcotics&rft.issn=0007523X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-22 N1 - Date created - 1989-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - HLA antigen frequencies in HIV-1 seropositive disease-free individuals and patients with AIDS. AN - 78633131; 3216293 AB - HLA-A, -B, -C, -DR, and -DQ antigen phenotypes were determined in 266 Caucasian homosexual men, 90 of whom were HIV-1 seronegative, 94 HIV-1 seropositive AIDS-free, and 82 with a diagnosis of AIDS [36 with Kaposi's sarcoma (KS), 34 with opportunistic infection (OI), and 12 with KS and OI]. No significant differences in HLA-A or -B antigen frequencies were found in any comparisons of these groups. However, in comparisons of seropositive AIDS-free men with the AIDS groups, HLA-Cw7 was increased in frequency in OI and HLA-DR1, -DRw14, and -DQw1 in KS. HLA-DR3 and -DQw3 frequencies were decreased in KS, and DRw53 was decreased in OI. In a cohort of 102 HIV seropositive individuals that were followed for a mean of 43 months, AIDS developed in HLA-DR1 positive men more frequently than in individuals with other HLA-DR phenotypes (p = 0.02). These results demonstrate probable genetic differences between individuals developing KS and OI and indicate that the HLA-DR1 phenotype is a risk factor in disease progression in human immunodeficiency virus (HIV)-infected individuals. JF - Journal of acquired immune deficiency syndromes AU - Mann, D L AU - Murray, C AU - Yarchoan, R AU - Blattner, W A AU - Goedert, J J AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 13 EP - 17 VL - 1 IS - 1 SN - 0894-9255, 0894-9255 KW - HLA Antigens KW - 0 KW - HLA-A Antigens KW - HLA-B Antigens KW - HLA-C Antigens KW - HLA-DQ Antigens KW - HLA-DR Antigens KW - Index Medicus KW - AIDS/HIV KW - HLA-DR Antigens -- analysis KW - HLA-A Antigens -- analysis KW - HLA-C Antigens -- analysis KW - Humans KW - Opportunistic Infections -- immunology KW - HLA-B Antigens -- analysis KW - HLA-DQ Antigens -- analysis KW - Sarcoma, Kaposi -- immunology KW - Opportunistic Infections -- complications KW - Male KW - Sarcoma, Kaposi -- etiology KW - Acquired Immunodeficiency Syndrome -- complications KW - Acquired Immunodeficiency Syndrome -- immunology KW - HLA Antigens -- analysis KW - HIV Seropositivity -- immunology KW - HIV-1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78633131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes&rft.atitle=HLA+antigen+frequencies+in+HIV-1+seropositive+disease-free+individuals+and+patients+with+AIDS.&rft.au=Mann%2C+D+L%3BMurray%2C+C%3BYarchoan%2C+R%3BBlattner%2C+W+A%3BGoedert%2C+J+J&rft.aulast=Mann&rft.aufirst=D&rft.date=1988-01-01&rft.volume=1&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes&rft.issn=08949255&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-09 N1 - Date created - 1989-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Detection and characterization of the protein encoded by the chicken c-rel protooncogene. AN - 78632612; 2851122 AB - We have identified the protein encoded by chicken c-rel, the cellular homolog of the v-rel oncogene carried by reticuloendotheliosis virus. The protein has been detected in two avian lymphoid cell lines and in chick embryo fibroblasts. It has a molecular weight of 68,000, suggesting that the viral gene (which encodes a protein of 59,000 molecular weight) is a truncated form of its cellular homolog. The c-rel protein is found in the soluble cytoplasmic fraction of chicken lymphoid cells and is not associated in any stable way with other cellular proteins. Unlike the viral protein, p68c-rel is not detectably phosphorylated. JF - Oncogene research AU - Simek, S AU - Rice, N R AD - Laboratory of Molecular Virology and Carcinogenesis, BRI-Basic Research Program, NCI-Frederick Cancer Research Facility, MD 21701. Y1 - 1988 PY - 1988 DA - 1988 SP - 103 EP - 119 VL - 2 IS - 2 SN - 0890-6467, 0890-6467 KW - Oncogene Proteins v-rel KW - 0 KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins c-rel KW - Retroviridae Proteins KW - Acetylglucosaminidase KW - EC 3.2.1.52 KW - Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase KW - EC 3.2.1.96 KW - Index Medicus KW - Animals KW - Chickens KW - Blotting, Northern KW - Phosphorylation KW - Peptide Mapping KW - Reticuloendotheliosis virus -- genetics KW - Genes, Viral KW - Cell Line KW - Fibroblasts KW - Retroviridae Proteins -- genetics KW - Retroviridae Proteins -- analysis KW - Proto-Oncogene Proteins -- analysis KW - Proto-Oncogenes KW - Proto-Oncogene Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78632612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene+research&rft.atitle=Detection+and+characterization+of+the+protein+encoded+by+the+chicken+c-rel+protooncogene.&rft.au=Simek%2C+S%3BRice%2C+N+R&rft.aulast=Simek&rft.aufirst=S&rft.date=1988-01-01&rft.volume=2&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Oncogene+research&rft.issn=08906467&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-01 N1 - Date created - 1989-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nitrite inhalants: patterns of abuse in Baltimore and Washington, D.C. AN - 78630455; 3265028 AB - Nitrite inhalants, as drugs of abuse, have received a new prominence in the literature since their use has been associated with Kaposi's Sarcoma and possibly other manifestations of acquired immunodeficiency syndrome (AIDS). Changes in patterns and prevalence of use have not been investigated since the onset of the AIDS epidemic. We have examined the abuse patterns of nitrite inhalants (poppers) in several different groups. The use of poppers among drug abusers in the Baltimore-Washington, D.C. metropolitan area has remained constant over the past 5 years, with the prevalence of use being approximately 11% for recreational drug users and 22% for heavy abusers. Self-reported use by a homosexual group had decreased over the same time period. Sixty-nine percent of the homosexual sample had experience with nitrities, but only 21% had used them in the 6 months prior to being surveyed. The mean interval since last use was 25 months, and since peak use, 4.1 years. Among substance abusers, nitrites appear to be a drug whose use starts late, with the mean age of first use being 25.6 years compared to 14.6 years for glue, 17.6 years for marijuana, and 18.5 years for heroin. We found both heterosexual and homosexual groups utilize nitrites primarily to "get high," but homosexuals more often use them during overt sexual activity. Experience with amyl nitrite was much more prevalent than that with the butyl derivative in both populations. We conclude that the prevalence of nitrite abuse among drug users has not changed as a result of the AIDS epidemic, but such use appears to have decreased within the homosexual community. JF - The American journal of drug and alcohol abuse AU - Lange, W R AU - Haertzen, C A AU - Hickey, J E AU - Snyder, F R AU - Dax, E M AU - Jaffe, J H AD - Addiction Research Center, National Institute on Drug Abuse, Baltimore, Maryland 21224. Y1 - 1988 PY - 1988 DA - 1988 SP - 29 EP - 39 VL - 14 IS - 1 SN - 0095-2990, 0095-2990 KW - Nitrites KW - 0 KW - Index Medicus KW - AIDS/HIV KW - District of Columbia KW - Cross-Sectional Studies KW - Humans KW - Adult KW - Acquired Immunodeficiency Syndrome -- psychology KW - Maryland KW - Homosexuality KW - Administration, Inhalation KW - Male KW - Female KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78630455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Nitrite+inhalants%3A+patterns+of+abuse+in+Baltimore+and+Washington%2C+D.C.&rft.au=Lange%2C+W+R%3BHaertzen%2C+C+A%3BHickey%2C+J+E%3BSnyder%2C+F+R%3BDax%2C+E+M%3BJaffe%2C+J+H&rft.aulast=Lange&rft.aufirst=W&rft.date=1988-01-01&rft.volume=14&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-10 N1 - Date created - 1989-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biochemical events associated with inhibition of B-cell proliferation by phorbol diesters. AN - 78630262; 3265131 AB - Phorbol myristate acelate (PMA), a potent tumor promoter, has a variety of effects on cells of the immune system resulting in altered patterns of cell proliferation and differentiation. Although PMA is mitogenic or co-mitogenic for human lymphocytes and murine T-cells, it inhibits proliferation of murine B-cells stimulated by LPS or anti-Ig. PMA, however, does not inhibit the ability of LPS or anti-Ig to activate B-cells, as evidenced by increased Ia antigen expression and RNA synthesis. In the present studies it was shown that inhibition of DNA synthesis by PMA coincided with qualitative and quantitative changes in phosphorylated proteins. In particular, PMA treatment resulted in a unique profile of phosphoproteins independent of LPS or anti-Ig treatment. Inhibition of DNA synthesis occurred over a wide range of PMA concentrations. At concentrations up to 10(-9) M, inhibition of proliferation correlated with decreased phosphatidylinositol turnover and decreased intracellular Ca2+ levels, suggesting that PMA affects the phosphoinositide signal transduction pathway. However, at PMA concentrations less than 10(-10) M, inhibition of anti-Ig- and LPS-mediated proliferation occurred without inhibition of the phosphoinositide transduction signal. At these concentrations, PMA-induced inhibition of DNA synthesis was highly sensitive to recombinant IL-2. These data suggest that the antiproliferative effects of PMA on B-cells stimulated by LPS or anti-Ig may be mediated by two mechanisms. At high concentrations, PMA causes a feedback regulation of the phosphoinositide-dependent messenger system, while at lower concentrations, PMA alters the response to specific growth factors. Since PMA induces unique phosphoproteins and both of these events can be regulated by protein phosphorylation, it is possible that these unique phosphoproteins are responsible for the antiproliferative effects of PMA. JF - International journal of immunopharmacology AU - Germolec, D R AU - Clark, G C AU - Blank, J A AU - Wiegand, G AU - Luster, M I AD - Systemic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 953 EP - 965 VL - 10 IS - 8 SN - 0192-0561, 0192-0561 KW - Antibodies, Anti-Idiotypic KW - 0 KW - Growth Substances KW - Lipopolysaccharides KW - Phosphatidylinositols KW - Phosphoproteins KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calcium -- metabolism KW - Phosphatidylinositols -- metabolism KW - Animals KW - Lipopolysaccharides -- pharmacology KW - Growth Substances -- pharmacology KW - Antibodies, Anti-Idiotypic -- administration & dosage KW - In Vitro Techniques KW - Mice KW - Phosphoproteins -- metabolism KW - Lymphocyte Activation -- drug effects KW - B-Lymphocytes -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - B-Lymphocytes -- immunology KW - B-Lymphocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78630262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+immunopharmacology&rft.atitle=Biochemical+events+associated+with+inhibition+of+B-cell+proliferation+by+phorbol+diesters.&rft.au=Germolec%2C+D+R%3BClark%2C+G+C%3BBlank%2C+J+A%3BWiegand%2C+G%3BLuster%2C+M+I&rft.aulast=Germolec&rft.aufirst=D&rft.date=1988-01-01&rft.volume=10&rft.issue=8&rft.spage=953&rft.isbn=&rft.btitle=&rft.title=International+journal+of+immunopharmacology&rft.issn=01920561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-06 N1 - Date created - 1989-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The activation of pyruvate dehydrogenase by glucagon in hepatocytes is diminished by phorbol myristate acetate: a role for cytoplasmic calcium in dehydrogenase regulation. AN - 78621387; 3213687 JF - Advances in experimental medicine and biology AU - Staddon, J M AU - Hansford, R G AD - National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224. Y1 - 1988 PY - 1988 DA - 1988 SP - 245 EP - 247 VL - 232 SN - 0065-2598, 0065-2598 KW - Pyruvate Dehydrogenase Complex KW - 0 KW - Glucagon KW - 9007-92-5 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats KW - Cytosol -- metabolism KW - Animals KW - Enzyme Activation KW - Cells, Cultured KW - Kinetics KW - Homeostasis KW - Liver -- enzymology KW - Glucagon -- pharmacology KW - Calcium -- physiology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Pyruvate Dehydrogenase Complex -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78621387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=The+activation+of+pyruvate+dehydrogenase+by+glucagon+in+hepatocytes+is+diminished+by+phorbol+myristate+acetate%3A+a+role+for+cytoplasmic+calcium+in+dehydrogenase+regulation.&rft.au=Staddon%2C+J+M%3BHansford%2C+R+G&rft.aulast=Staddon&rft.aufirst=J&rft.date=1988-01-01&rft.volume=232&rft.issue=&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-16 N1 - Date created - 1989-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of sodium azide on sea urchin embryos and gametes. AN - 78611075; 2905547 AB - Sodium azide (SA) was tested on sea urchin embryos and gametes (Paracentrotus lividus). Developing embryos were exposed to SA (10(-6) to 10(-3) M) up to pluteus larval stage, or for shorter intervals before or after hatching. Developmental defects in SA-exposed embryos consisted mainly of gut abnormalities, without any detectable differences between pre- or post-hatch-exposed embryos. SA-induced damage to gut was exerted during gastrulation, as evident by lectin binding of extracellular matrix. No mitotic damage was observed in SA-exposed embryos, nor could pH-related variations be detected in SA-induced embryotoxicity at pH's ranging from 8 to 6. Concurrently, no effect ensued in the exposure of unfertilized eggs to SA (10(-5) to 10(-2) M) both in terms of fertilization success and of offspring quality. When sperm were suspended in filtered seawater at pH's ranging from 8 to 6, and SA levels ranging from 10(-5) to 10(-2) M, fertilization success of SA-exposed sperm appeared to be modulated by pH, by displaying three distinct dose-response trends at pH 8, 7, or 6. The consequences of sperm pretreatment on offspring quality failed to show any significant SA-induced changes on larval malformations or mortality, while confirming the previously reported pH-induced increase of developmental defects in the offspring of acid-exposed sperm (Pagano et al.: Teratogenesis Carcinogen Mutagen 5:113-121, 1985). JF - Teratogenesis, carcinogenesis, and mutagenesis AU - Pagano, G AU - Cipollaro, M AU - Corsale, G AU - Esposito, A AU - Mineo, A AU - Ragucci, E AU - Giordano, G G AU - Kobayashi, N AU - Trieff, N M AD - National Cancer Institute, Fondazione G. Pascale, Naples, Italy. Y1 - 1988 PY - 1988 DA - 1988 SP - 363 EP - 376 VL - 8 IS - 6 SN - 0270-3211, 0270-3211 KW - Azides KW - 0 KW - Sodium Azide KW - 968JJ8C9DV KW - Index Medicus KW - Intestines -- embryology KW - Animals KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Hydrogen-Ion Concentration KW - Mitosis -- drug effects KW - Fertilization -- drug effects KW - Male KW - Spermatozoa -- drug effects KW - Sea Urchins -- embryology KW - Azides -- toxicity KW - Ovum -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78611075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.atitle=Effects+of+sodium+azide+on+sea+urchin+embryos+and+gametes.&rft.au=Pagano%2C+G%3BCipollaro%2C+M%3BCorsale%2C+G%3BEsposito%2C+A%3BMineo%2C+A%3BRagucci%2C+E%3BGiordano%2C+G+G%3BKobayashi%2C+N%3BTrieff%2C+N+M&rft.aulast=Pagano&rft.aufirst=G&rft.date=1988-01-01&rft.volume=8&rft.issue=6&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+carcinogenesis%2C+and+mutagenesis&rft.issn=02703211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-16 N1 - Date created - 1989-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alterations in craniofacial growth induced by isotretinoin (13-cis-retinoic acid) in mouse whole embryo and primary mesenchymal cell culture. AN - 78606190; 3209676 AB - Recent evidence has demonstrated that 13-cis-retinoic acid (13-cis-RA, or isotretinoin) is responsible for various craniofacial malformations in the rodent and human embryo. Our studies have been directed toward understanding this effect using mouse whole embryo and primary cell cultures. In whole embryo culture, 13-cis-RA caused significant overall embryonic growth retardation, especially in the primary and secondary palatal processes. In embryos explanted on day 10 of gestation and exposed for 24 or 48 hr, the mesenchyme beneath the epithelium of the nasal and maxillary processes contained pyknotic nuclei as well as a dramatically reduced number of nuclei incorporating 3H-thymidine. The secondary palatal processes and the roof of the oral-nasal cavity had fewer mesenchymal cells than control embryos. The incorporation of 3H-thymidine into TCA-insoluble macromolecules was 30% less in the retinoid-treated heads. In primary cell cultures from day-12 mouse secondary palatal mesenchyme, subsequent cell growth was decreased at concentrations of 13-cis-RA greater than 1 X 10(-5) M. After a 40-hr treatment period, labeling indices in retinoid-treated cells were significantly lower than control values (25% compared with 40%). Retinoic acid also caused a significant, concentration-dependent decrease in 3H-thymidine incorporation. The inhibitory effect of 13-cis-RA on proliferation of oral-nasal mesenchymal cells appears to be related to the production of craniofacial malformations. JF - Journal of craniofacial genetics and developmental biology AU - Watanabe, T AU - Goulding, E H AU - Pratt, R M AD - Experimental Teratogenesis Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 21 EP - 33 VL - 8 IS - 1 SN - 0270-4145, 0270-4145 KW - Teratogens KW - 0 KW - Isotretinoin KW - EH28UP18IF KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Reference Values KW - Cells, Cultured KW - Mice KW - Organ Culture Techniques KW - Female KW - DNA Replication -- drug effects KW - Pregnancy KW - Skull -- embryology KW - Palate -- drug effects KW - Facial Bones -- embryology KW - Facial Bones -- abnormalities KW - Skull -- abnormalities KW - Facial Bones -- drug effects KW - Skull -- drug effects KW - Isotretinoin -- toxicity KW - Embryo, Mammalian -- drug effects KW - Palate -- embryology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78606190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+craniofacial+genetics+and+developmental+biology&rft.atitle=Alterations+in+craniofacial+growth+induced+by+isotretinoin+%2813-cis-retinoic+acid%29+in+mouse+whole+embryo+and+primary+mesenchymal+cell+culture.&rft.au=Watanabe%2C+T%3BGoulding%2C+E+H%3BPratt%2C+R+M&rft.aulast=Watanabe&rft.aufirst=T&rft.date=1988-01-01&rft.volume=8&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Journal+of+craniofacial+genetics+and+developmental+biology&rft.issn=02704145&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-23 N1 - Date created - 1989-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Novel phosphorylation of c-ras p21 by protein kinases. AN - 78605961; 2849744 AB - Novel p21 phosphorylation was found in cells expressing high levels of this product of c-H- and c-K-ras genes. Phorbol 12,13-dibutyrate, a protein kinase C (PKC) activator, and permeable c-AMP derivatives, which activate protein kinase A (PKA), stimulated phosphorylation of K-ras(4B) p21 in 416B cells 3 to 5 fold. By tryptic peptide mapping, it was found that both PKC and PKA phosphorylated in vitro the K-ras p21 at the same site as was found in p21 from cells labeled with [32P]orthophosphate in vivo. A common site of H-ras p21 was also phosphorylated by both PKC and PKA, although phosphopeptides of H-ras p21 were distinct from those of K-ras p21. The construction of a mutant by site-directed mutagenesis allowed the identification of serine-177 as the phosphorylation site of H-ras p21. This novel phosphorylation site lies in the hypervariable region, which links the globular catalytic domain of p21 to the membrane-anchoring site at the C-terminus, a location suggesting that this phosphorylation plays a role in modulating transmembrane signaling. JF - Oncogene research AU - Saikumar, P AU - Ulsh, L S AU - Clanton, D J AU - Huang, K P AU - Shih, T Y AD - Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland 21701. Y1 - 1988 PY - 1988 DA - 1988 SP - 213 EP - 222 VL - 3 IS - 3 SN - 0890-6467, 0890-6467 KW - Protein Kinase Inhibitors KW - 0 KW - Proto-Oncogene Proteins KW - Recombinant Fusion Proteins KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinases KW - EC 2.7.- KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - Index Medicus KW - Animals KW - Peptide Mapping KW - Protein Processing, Post-Translational KW - Amino Acid Sequence KW - Phorbol 12,13-Dibutyrate -- pharmacology KW - Recombinant Fusion Proteins -- metabolism KW - Rats KW - Phosphorylation KW - Cyclic AMP -- metabolism KW - Molecular Sequence Data KW - Protein Conformation KW - Protein Kinases -- metabolism KW - Proto-Oncogene Proteins -- metabolism KW - Proto-Oncogene Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78605961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene+research&rft.atitle=Novel+phosphorylation+of+c-ras+p21+by+protein+kinases.&rft.au=Saikumar%2C+P%3BUlsh%2C+L+S%3BClanton%2C+D+J%3BHuang%2C+K+P%3BShih%2C+T+Y&rft.aulast=Saikumar&rft.aufirst=P&rft.date=1988-01-01&rft.volume=3&rft.issue=3&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Oncogene+research&rft.issn=08906467&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-06 N1 - Date created - 1989-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhalant overview. AN - 78602239; 3145433 JF - NIDA research monograph AU - Crider, R A AU - Rouse, B A AD - Division of Epidemiology and Statistical Analysis, National Institute on Drug Abuse. Y1 - 1988 PY - 1988 DA - 1988 SP - 1 EP - 7 VL - 85 SN - 1046-9516, 1046-9516 KW - Aerosols KW - 0 KW - Solvents KW - Index Medicus KW - Humans KW - Administration, Inhalation KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78602239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Inhalant+overview.&rft.au=Crider%2C+R+A%3BRouse%2C+B+A&rft.aulast=Crider&rft.aufirst=R&rft.date=1988-01-01&rft.volume=85&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-22 N1 - Date created - 1989-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment services for adolescent drug abusers: introduction and overview. AN - 78601873; 3145423 JF - NIDA research monograph AU - Rahdert, E R AD - Division of Clinical Research, National Institute on Drug Abuse, Rockville, Maryland 20857. Y1 - 1988 PY - 1988 DA - 1988 SP - 1 EP - 3 VL - 77 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - Humans KW - Michigan KW - Adolescent KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Health Services -- economics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78601873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Treatment+services+for+adolescent+drug+abusers%3A+introduction+and+overview.&rft.au=Rahdert%2C+E+R&rft.aulast=Rahdert&rft.aufirst=E&rft.date=1988-01-01&rft.volume=77&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-13 N1 - Date created - 1989-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mortality among agricultural extension agents. AN - 78597132; 3207102 AB - The mortality experience of agricultural extension agents in the Cooperative Extension Service (CES) of the U.S. Department of Agriculture who died during the period January 1, 1970-December 31, 1979 (n = 1,495 white males) was evaluated in proportionate-mortality and case-control studies. The proportionate-mortality analysis was used to identify cancers that might be elevated in this occupational group compared with the U.S. white male population. All cancers with a significantly elevated proportionate-mortality ratio were more thoroughly evaluated in the case-control study, where there is presumably less of a selection bias in the comparison. In the case-control study, leukemia demonstrated a statistically significant linear trend with duration of employment as an extension agent. Smaller, but nonsignificant, trends were seen for non-Hodgkin's lymphoma, multiple myeloma, and brain cancer. The odds ratio for Hodgkin's disease and cancers of the colon, prostate, and kidney did not vary with the number of years on the job. These patterns resemble cancer risks seen among farmers, suggesting that agricultural factors may also play a role in the origin of these tumors among extension agents. JF - American journal of industrial medicine AU - Alavanja, M C AU - Blair, A AU - Merkle, S AU - Teske, J AU - Eaton, B AD - Division of Cancer Etiology, National Cancer Institute, Bethesda, MD. Y1 - 1988 PY - 1988 DA - 1988 SP - 167 EP - 176 VL - 14 IS - 2 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - United States KW - Leukemia -- mortality KW - Neoplasms -- mortality KW - Aged, 80 and over KW - Risk Factors KW - Humans KW - Adult KW - Environmental Exposure KW - Aged KW - Middle Aged KW - Male KW - Agricultural Workers' Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78597132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Mortality+among+agricultural+extension+agents.&rft.au=Alavanja%2C+M+C%3BBlair%2C+A%3BMerkle%2C+S%3BTeske%2C+J%3BEaton%2C+B&rft.aulast=Alavanja&rft.aufirst=M&rft.date=1988-01-01&rft.volume=14&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-09 N1 - Date created - 1989-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Amino acid sequence and physiological characterization of toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann. AN - 78581826; 2849217 AB - The complete amino acid sequence of the major toxic component (II.20.3.4), named toxin 1, from the venom of the Mexican scorpion C. l. tecomanus is reported. The sequence (66 amino acids) was obtained by direct Edman degradation of reduced and alkylated toxin, followed by sequence determination of selected peptides separated after enzymatic cleavage with S. aureus V8 protease. In cultured chick dorsal root ganglion cells, 0.5 microM toxin 1 slowed down specifically the time course of Na+ current inactivation, while Ca2+ currents from the same preparation were little affected. In neonatal rat ventricular heart cells, toxin 1, at concentrations between 0.1 and 0.5 microM, reduced Na+ currents without changing the kinetics and Ca2+ currents were unaffected. Comparative analysis of the primary structure of this toxin with other scorpion toxins shows a high degree of similarity with the north American scorpion toxins. This analysis suggests that the 'fine tuning' of the molecular mechanism of action of these toxins is related to variations in the primary structure as well as to the type of membrane under study (tissue specificity). JF - Toxicon : official journal of the International Society on Toxinology AU - Martin, B M AU - Carbone, E AU - Yatani, A AU - Brown, A M AU - Ramírez, A N AU - Gurrola, G B AU - Possani, L D AD - National Institute of Mental Health, Molecular Neurogenetics Unit, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 785 EP - 794 VL - 26 IS - 9 SN - 0041-0101, 0041-0101 KW - Scorpion Venoms KW - 0 KW - Sodium Channels KW - Index Medicus KW - Rats KW - Animals KW - Chick Embryo KW - Molecular Sequence Data KW - Heart -- drug effects KW - Amino Acid Sequence KW - Action Potentials -- drug effects KW - Ganglia, Spinal -- drug effects KW - Sodium Channels -- drug effects KW - Scorpion Venoms -- analysis KW - Scorpion Venoms -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78581826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Amino+acid+sequence+and+physiological+characterization+of+toxins+from+the+venom+of+the+scorpion+Centruroides+limpidus+tecomanus+Hoffmann.&rft.au=Martin%2C+B+M%3BCarbone%2C+E%3BYatani%2C+A%3BBrown%2C+A+M%3BRam%C3%ADrez%2C+A+N%3BGurrola%2C+G+B%3BPossani%2C+L+D&rft.aulast=Martin&rft.aufirst=B&rft.date=1988-01-01&rft.volume=26&rft.issue=9&rft.spage=785&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-26 N1 - Date created - 1989-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cocaine-induced behavioral sensitization and kindling: implications for the emergence of psychopathology and seizures. AN - 78581731; 2904782 JF - Annals of the New York Academy of Sciences AU - Post, R M AU - Weiss, S R AU - Pert, A AD - Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 292 EP - 308 VL - 537 SN - 0077-8923, 0077-8923 KW - Antipsychotic Agents KW - 0 KW - Amphetamine KW - CK833KGX7E KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Drug Tolerance KW - Animals KW - Nucleus Accumbens -- drug effects KW - Nucleus Accumbens -- physiology KW - Antipsychotic Agents -- pharmacology KW - Conditioning (Psychology) -- physiology KW - Caudate Nucleus -- drug effects KW - Amygdala -- physiology KW - Amphetamine -- pharmacology KW - Caudate Nucleus -- physiology KW - Seizures -- chemically induced KW - Behavior, Animal -- drug effects KW - Kindling, Neurologic -- drug effects KW - Mental Disorders -- chemically induced KW - Cocaine -- toxicity KW - Cocaine -- pharmacology KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78581731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Cocaine-induced+behavioral+sensitization+and+kindling%3A+implications+for+the+emergence+of+psychopathology+and+seizures.&rft.au=Post%2C+R+M%3BWeiss%2C+S+R%3BPert%2C+A&rft.aulast=Post&rft.aufirst=R&rft.date=1988-01-01&rft.volume=537&rft.issue=&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-23 N1 - Date created - 1989-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intradentate colchicine disrupts the acquisition and performance of a working memory task in the radial arm maze. AN - 78578600; 3200514 AB - Rats were given bilateral injections of colchicine into the dorsal and ventral hippocampus to study the role of the dentate gyrus granule cells in the acquisition and performance of a spatial, working memory task in the radial arm maze. Three weeks after intradentate injections, rats were trained in a task in which all eight arms were baited prior to each daily trail. For up to 20 days of training, colchicine-treated rats were significantly impaired in the performance of the task. In another study, rats received 20 days of training and then were given intradentate colchicine. Three weeks later, the performance of the colchicine-treated rats was impaired for up to 20 days of testing. A third experiment tested the ability of colchicine-treated rats to learn a task in which the same four arms of the maze were baited, while the remaining arms were never baited. Colchicine-treated rats were significantly impaired in their ability to perform this version of the task. Histological verification indicated that colchicine resulted in a relatively select loss of granule cells, while sparing pyramidal cells in the hippocampus. These data suggest that the hippocampus plays an integral role in the performance of the place tasks used in these experiments. JF - Neurotoxicology AU - McLamb, R L AU - Mundy, W R AU - Tilson, H A AD - Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 521 EP - 528 VL - 9 IS - 3 SN - 0161-813X, 0161-813X KW - Colchicine KW - SML2Y3J35T KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Retention (Psychology) -- drug effects KW - Hippocampus -- pathology KW - Male KW - Hippocampus -- drug effects KW - Colchicine -- toxicity KW - Memory -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78578600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Intradentate+colchicine+disrupts+the+acquisition+and+performance+of+a+working+memory+task+in+the+radial+arm+maze.&rft.au=McLamb%2C+R+L%3BMundy%2C+W+R%3BTilson%2C+H+A&rft.aulast=McLamb&rft.aufirst=R&rft.date=1988-01-01&rft.volume=9&rft.issue=3&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-19 N1 - Date created - 1989-01-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The therapeutic latency of neuroleptic drugs and nonspecific postjunctional supersensitivity. AN - 78574575; 2904695 AB - It is suggested that the antidopaminergic effects of neuroleptics are not directly responsible for the antipsychotic effect but, rather, that the antipsychotic effect is related to secondary changes in the efficacy of transmission at corticostriatal excitatory synapses. Arguments are presented in support of the following: (1) acute dopaminergic antagonism produces a relatively nonspecific sedation or deactivation, but most of the amelioration of psychosis develops slowly; (2) the development of dopaminergic supersensitivity is responsible for tolerance to the sedative effects of neuroleptics; and (3) excitatory synapses of the corticostriatal pathway, mediated by glutamic acid, are located on the same dendritic spines as the striatal dopaminergic synapses. Concomitant with the development of dopaminergic supersensitivity, these glutamate synapses become subsensitive. The glutamatergic subsensitivity is a result of the nonspecific nature of postsynaptic denervation supersensitivity. It is suggested that subsensitivity of striatal glutamate-mediated synapses is directly responsible for the antipsychotic effect of neuroleptic drugs. In support of this hypothesis, chronic neuroleptic administration was found to decrease the behavioral responsivity of mice to the glutamate agonist, quisqualic acid, and to the the antagonist, glutamic acid diethyl ester. JF - Schizophrenia bulletin AU - Freed, W J AD - Neuropsychiatry Branch, NIMH, Neuropsychiatric Research Hospital at Saint Elizabeths, Washington, DC 20032. Y1 - 1988 PY - 1988 DA - 1988 SP - 269 EP - 277 VL - 14 IS - 2 SN - 0586-7614, 0586-7614 KW - Antipsychotic Agents KW - 0 KW - Receptors, Dopamine KW - Receptors, Glutamate KW - Receptors, Neurotransmitter KW - Index Medicus KW - Animals KW - Humans KW - Receptors, Neurotransmitter -- drug effects KW - Mice KW - Receptors, Dopamine -- drug effects KW - Brain -- drug effects KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenic Psychology KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78574575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+bulletin&rft.atitle=The+therapeutic+latency+of+neuroleptic+drugs+and+nonspecific+postjunctional+supersensitivity.&rft.au=Freed%2C+W+J&rft.aulast=Freed&rft.aufirst=W&rft.date=1988-01-01&rft.volume=14&rft.issue=2&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+bulletin&rft.issn=05867614&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-19 N1 - Date created - 1989-01-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Behavioral impairment in the rat after colchicine lesions of the hippocampus and nucleus basalis. AN - 78574463; 3200513 AB - Rats were given bilateral injections of colchicine into the nucleus basalis (NBM; 1.0 or 2.0 micrograms/site), hippocampus (HPC; 1.25 or 2.5 micrograms/site), or both areas (COM; 1.0 NBM, 1.25 HPC) and examined for changes in locomotor activity, passive avoidance behavior, and spatial navigation in a water maze task. Colchicine injected into the HPC caused a dose-related increase in locomotor activity 7 days after treatment which declined with repeated testing. Motor activity in NBM-lesioned rats was not significantly different from control. Rats with the COM lesion were more active than controls 7 days after treatment and remained hyperactive over the 3 week testing period. Retention of a step-through passive avoidance task was examined 18 days after surgery. HPC lesions had no apparent effect on passive avoidance behavior. NBM lesions causes a dose-dependent decrease in step-through latencies, while latencies in the combined group were comparable to the low dose NBM group. In the spatial navigation task, HPC and COM lesions impaired acquisition, with little indication of learning in the combined group. NBM lesions had no effect in the water maze. These data suggest that combined lesions of the NBM and HPC cause lasting behavioral impairments and may be useful as a model for neurodegenerative disorders such as Alzheimer's disease. JF - Neurotoxicology AU - Mundy, W R AU - Tilson, H A AD - Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 511 EP - 519 VL - 9 IS - 3 SN - 0161-813X, 0161-813X KW - Colchicine KW - SML2Y3J35T KW - Index Medicus KW - Rats KW - Animals KW - Swimming KW - Rats, Inbred F344 KW - Motor Activity -- drug effects KW - Avoidance Learning -- drug effects KW - Male KW - Colchicine -- toxicity KW - Behavior, Animal -- drug effects KW - Basal Ganglia -- drug effects KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78574463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Behavioral+impairment+in+the+rat+after+colchicine+lesions+of+the+hippocampus+and+nucleus+basalis.&rft.au=Mundy%2C+W+R%3BTilson%2C+H+A&rft.aulast=Mundy&rft.aufirst=W&rft.date=1988-01-01&rft.volume=9&rft.issue=3&rft.spage=511&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-19 N1 - Date created - 1989-01-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fatty acylation of proteins. AN - 78569273; 3058168 JF - Annual review of cell biology AU - Schultz, A M AU - Henderson, L E AU - Oroszlan, S AD - Laboratory of Molecular Virology and Carcinogenesis, NCI-Frederick Cancer Research Facility, Maryland 21701. Y1 - 1988 PY - 1988 DA - 1988 SP - 611 EP - 647 VL - 4 SN - 0743-4634, 0743-4634 KW - Amides KW - 0 KW - Esters KW - Fatty Acids KW - Myelin Proteins KW - Phosphatidylinositols KW - Proteins KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Animals KW - Solubility KW - Myelin Proteins -- physiology KW - Acylation KW - Structure-Activity Relationship KW - Protein Processing, Post-Translational KW - Proteins -- metabolism KW - Fatty Acids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78569273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+cell+biology&rft.atitle=Fatty+acylation+of+proteins.&rft.au=Schultz%2C+A+M%3BHenderson%2C+L+E%3BOroszlan%2C+S&rft.aulast=Schultz&rft.aufirst=A&rft.date=1988-01-01&rft.volume=4&rft.issue=&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+cell+biology&rft.issn=07434634&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-18 N1 - Date created - 1989-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dosimeters of human exposure to carcinogens: polycyclic aromatic hydrocarbon-macromolecular adducts. AN - 78568164; 3143667 AB - The metabolic activation of polycyclic aromatic hydrocarbons (PAH), for example benzo[a]pyrene, leads to the formation of carcinogen-macromolecular adducts. Methods that make it possible to detect low levels of these adducts in human peripheral blood samples should be useful in the dosimetry of human exposure to carcinogens. We demonstrated previously the usefulness of enzyme immunoassays and of synchronous fluorescence spectroscopy (SFS) for detecting and characterizing low levels of PAH-macromolecular adducts present in synthetic adduct mixtures. These methods have now been refined and applied to the analysis of samples of peripheral blood collected from occupationally exposed individuals (coke-oven workers) and from people attending smoking cessation clinics. The results of both immunoassays and SFS show the presence of benzo[a]pyrene diol epoxide (BPDE)-DNA, BPDE-haemoglobin and other putative PAH-macromolecular adducts in peripheral blood samples from certain individuals. JF - IARC scientific publications AU - Weston, A AU - Willey, J C AU - Manchester, D K AU - Wilson, V L AU - Brooks, B R AU - Choi, J S AU - Poirier, M C AU - Trivers, G E AU - Newman, M J AU - Mann, D L AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD. Y1 - 1988 PY - 1988 DA - 1988 SP - 181 EP - 189 IS - 89 SN - 0300-5038, 0300-5038 KW - Carcinogens, Environmental KW - 0 KW - DNA Adducts KW - Hemoglobins KW - Phosphorus Radioisotopes KW - Polycyclic Compounds KW - benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide KW - 55097-80-8 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide -- immunology KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide -- analysis KW - Spectrometry, Fluorescence KW - Hemoglobins -- metabolism KW - Humans KW - Immunoassay KW - DNA -- metabolism KW - DNA -- analysis KW - Carcinogens, Environmental -- metabolism KW - DNA -- immunology KW - Polycyclic Compounds -- metabolism KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78568164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=Dosimeters+of+human+exposure+to+carcinogens%3A+polycyclic+aromatic+hydrocarbon-macromolecular+adducts.&rft.au=Weston%2C+A%3BWilley%2C+J+C%3BManchester%2C+D+K%3BWilson%2C+V+L%3BBrooks%2C+B+R%3BChoi%2C+J+S%3BPoirier%2C+M+C%3BTrivers%2C+G+E%3BNewman%2C+M+J%3BMann%2C+D+L&rft.aulast=Weston&rft.aufirst=A&rft.date=1988-01-01&rft.volume=&rft.issue=89&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-18 N1 - Date created - 1989-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of oncogenes in chemical carcinogenesis: extrapolation from rodents to humans. AN - 78567683; 3058603 AB - Proto-oncogenes are cellular genes that are expressed during normal growth and development processes. These genes can be activated to cancer-causing oncogenes by point mutations or by gross DNA rearrangement, such as chromosomal translocation or gene amplification. Activated versions of proto-oncogenes have been observed in various human and rodent tumours. Examples will be discussed, as will the activation of proto-oncogenes by chemical carcinogens. Most chemicals are classified as potentially hazardous to humans on the basis of long-term carcinogenesis studies in rodents. Oncogene analysis of tumours of spontaneous origin and from carcinogenesis studies may aid in risk analyses on the basis of rodent carcinogenesis studies. JF - IARC scientific publications AU - Anderson, M W AU - Maronpot, R R AU - Reynolds, S H AD - Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC. Y1 - 1988 PY - 1988 DA - 1988 SP - 477 EP - 485 IS - 89 SN - 0300-5038, 0300-5038 KW - Carcinogens KW - 0 KW - Index Medicus KW - Rats KW - Carcinogens -- pharmacology KW - Animals KW - Transfection KW - Humans KW - Mice KW - Translocation, Genetic KW - Gene Amplification KW - Neoplasms -- chemically induced KW - Proto-Oncogenes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78567683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=Role+of+oncogenes+in+chemical+carcinogenesis%3A+extrapolation+from+rodents+to+humans.&rft.au=Anderson%2C+M+W%3BMaronpot%2C+R+R%3BReynolds%2C+S+H&rft.aulast=Anderson&rft.aufirst=M&rft.date=1988-01-01&rft.volume=&rft.issue=89&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-18 N1 - Date created - 1989-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Behavioral symptomatology in dementia of the Alzheimer type. AN - 78567455; 3196470 JF - Alzheimer disease and associated disorders AU - Kumar, A AU - Koss, E AU - Metzler, D AU - Moore, A AU - Friedland, R P AD - Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 363 EP - 365 VL - 2 IS - 4 SN - 0893-0341, 0893-0341 KW - Index Medicus KW - Humans KW - Mental Disorders -- diagnosis KW - Depression -- etiology KW - Alzheimer Disease -- complications KW - Mental Disorders -- etiology KW - Depression -- diagnosis KW - Paranoid Disorders -- etiology KW - Paranoid Disorders -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78567455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alzheimer+disease+and+associated+disorders&rft.atitle=Behavioral+symptomatology+in+dementia+of+the+Alzheimer+type.&rft.au=Kumar%2C+A%3BKoss%2C+E%3BMetzler%2C+D%3BMoore%2C+A%3BFriedland%2C+R+P&rft.aulast=Kumar&rft.aufirst=A&rft.date=1988-01-01&rft.volume=2&rft.issue=4&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Alzheimer+disease+and+associated+disorders&rft.issn=08930341&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-26 N1 - Date created - 1989-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - DNA restriction fragment length polymorphism analysis of human bronchogenic carcinoma. AN - 78565196; 2904414 AB - DNA restriction fragment length polymorphism (RFLP) analysis has been successfully applied both to evaluate possible human susceptibility factors as well as to identify genes involved in malignant transformation of human cells. In this report we review previous applications of RFLP analysis to evaluation of human malignancies and discuss our RFLP studies of human bronchogenic carcinoma, which are in progress. Preliminary results of our analysis of the RFLP associated with the cHa ras variable tandem repeat (VTR) indicate that rare alleles of this VTR are more frequent in patients with bronchogenic carcinoma than in controls. JF - IARC scientific publications AU - Willey, J C AU - Weston, A AU - Haugen, A AU - Krontiris, T AU - Resau, J AU - McDowell, E AU - Trump, B AU - Harris, C C AD - Laboratory of Human Carcinogenesis, National Institutes of Health, Bethesda, MD. Y1 - 1988 PY - 1988 DA - 1988 SP - 439 EP - 450 IS - 89 SN - 0300-5038, 0300-5038 KW - Index Medicus KW - Genes KW - Humans KW - Mutation KW - Carcinoma, Bronchogenic -- etiology KW - Carcinoma, Bronchogenic -- genetics KW - Polymorphism, Restriction Fragment Length KW - Polymorphism, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78565196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=DNA+restriction+fragment+length+polymorphism+analysis+of+human+bronchogenic+carcinoma.&rft.au=Willey%2C+J+C%3BWeston%2C+A%3BHaugen%2C+A%3BKrontiris%2C+T%3BResau%2C+J%3BMcDowell%2C+E%3BTrump%2C+B%3BHarris%2C+C+C&rft.aulast=Willey&rft.aufirst=J&rft.date=1988-01-01&rft.volume=&rft.issue=89&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-18 N1 - Date created - 1989-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Uterine receptivity for blastocyst implantation. AN - 78563476; 3057996 AB - The receptivity for blastocyst implantation is controlled by progesterone and in some species by the synergistic action of progesterone and estrogen. The duration of the receptive phase, the so-called "window," is short in rodents (less than 24 hours) and may be three days in the primate. Once the uterus becomes receptive, it automatically becomes refractory at the end of the receptive phase. The uterus in the refractory phase can be toxic to the blastocyst in small laboratory animals. The endometrium of the receptive uterus may be characterized by the following parameters: (1) Formation of bulbous protrusions on the apical surface of the luminal epithelium; (2) Secretion of the stage-specific glycoproteins by the luminal epithelium; (3) Readiness of stromal cells to decidualize when appropriate stimulation is applied; and (4) Reorganization and changes of stromal extracellular matrix components so that stromal cells are conditioned for decidualization, and after decidualization the appearance of basement membrane components in the matrix. JF - Annals of the New York Academy of Sciences AU - Yoshinaga, K AD - Reproductive Sciences Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 424 EP - 431 VL - 541 SN - 0077-8923, 0077-8923 KW - Index Medicus KW - Embryonic and Fetal Development KW - Humans KW - Embryo Transfer KW - Female KW - Pregnancy KW - Embryo Implantation KW - Uterus -- physiology KW - Blastocyst -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78563476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Uterine+receptivity+for+blastocyst+implantation.&rft.au=Yoshinaga%2C+K&rft.aulast=Yoshinaga&rft.aufirst=K&rft.date=1988-01-01&rft.volume=541&rft.issue=&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-06 N1 - Date created - 1989-01-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Radon-222 concentration in groundwater and cancer mortality in North Carolina. AN - 78563083; 3198278 AB - In a geographic correlation study, we explored the possibility that residential exposure to radon in groundwater may be related to cancers other than lung cancer. Measurements of radon in groundwater and 1978-1982 cancer mortality data from North Carolina, USA were used to investigate this relationship. Counties were categorized in two levels of radon exposure according to measured radon concentration and geology. In the lower exposure group (unexposed) county mean radon concentrations ranged from 0-228 pCi/l (0-8436 Bq/m3), and in the upper group (potentially exposed) the range of county average concentrations was 229-10892 pCi/l (8473-403004 Bq/m3) (median 1375 pCi/l (50875 Bq/m3)). Adjusted mortality ratios and 95% confidence intervals were calculated for selected cancers, including leukemias, gastro-intestinal tract cancers, and respiratory tract cancers excluding lung cancer. In contrast to other ecologic studies, we found no consistent association between radon level and cancer mortality. JF - International archives of occupational and environmental health AU - Collman, G W AU - Loomis, D P AU - Sandler, D P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 13 EP - 18 VL - 61 IS - 1-2 SN - 0340-0131, 0340-0131 KW - Water Pollutants KW - 0 KW - Water Pollutants, Radioactive KW - Radon KW - Q74S4N8N1G KW - Index Medicus KW - Sex Factors KW - Risk Factors KW - Humans KW - North Carolina KW - Male KW - Female KW - Water Pollutants -- analysis KW - Neoplasms -- mortality KW - Radon -- analysis KW - Water Pollutants, Radioactive -- analysis KW - Neoplasms, Radiation-Induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78563083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+archives+of+occupational+and+environmental+health&rft.atitle=Radon-222+concentration+in+groundwater+and+cancer+mortality+in+North+Carolina.&rft.au=Collman%2C+G+W%3BLoomis%2C+D+P%3BSandler%2C+D+P&rft.aulast=Collman&rft.aufirst=G&rft.date=1988-01-01&rft.volume=61&rft.issue=1-2&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=International+archives+of+occupational+and+environmental+health&rft.issn=03400131&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-25 N1 - Date created - 1989-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Magnetic resonance imaging (MRI): a new tool in experimental toxicologic pathology. AN - 78542251; 3194661 AB - Magnetic Resonance Imaging (MRI) is a noninvasive imaging technique that provides multidimensional images of the soft tissues of the body. This imaging technique has proven to be an excellent diagnostic and experimental tool for the detection of pathologic alterations in soft tissues, as well as an adjunct screening method for following the genesis, progression, or regression of chemically induced lesions in the same live animal. Future applications of MRI technology in small animals include MRI microscopy, mapping of vascular or circulatory alterations, measurement of perfusion and diffusion rates of body fluids, and acquisition of cell metabolic states in combination with Nuclear Magnetic Resonance (NMR) spectroscopy, all of which will contribute immensely to the advancement of toxicologic and biomolecular research. JF - Toxicologic pathology AU - Dixon, D AU - Johnson, G A AU - Cofer, G P AU - Hedlund, L W AU - Maronpot, R R AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 386 EP - 391 VL - 16 IS - 3 SN - 0192-6233, 0192-6233 KW - Index Medicus KW - Rats KW - Animals KW - Magnetic Resonance Imaging KW - Pathology KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78542251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Magnetic+resonance+imaging+%28MRI%29%3A+a+new+tool+in+experimental+toxicologic+pathology.&rft.au=Dixon%2C+D%3BJohnson%2C+G+A%3BCofer%2C+G+P%3BHedlund%2C+L+W%3BMaronpot%2C+R+R&rft.aulast=Dixon&rft.aufirst=D&rft.date=1988-01-01&rft.volume=16&rft.issue=3&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-28 N1 - Date created - 1988-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Leukemias and occupation in Sweden: a registry-based analysis. AN - 78535865; 3189348 AB - A linked-registry was used to examine systematically, on a national basis, the leukemia incidence in Swedish men by industry and occupation. New associations were observed for chronic lymphocytic leukemia among cloth and pattern cutters and for chronic myelocytic leukemia among brewery workers and motor mechanics. A number of additional findings were consistent with previous observations in other countries. Although etiologic inferences are limited when using linked-registry data, this hypothesis-generating study may provide new clues to the occupational determinants of specific forms of leukemia. JF - American journal of industrial medicine AU - Linet, M S AU - Malker, H S AU - McLaughlin, J K AU - Weiner, J A AU - Stone, B J AU - Blot, W J AU - Ericsson, J L AU - Fraumeni, J F AD - Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 319 EP - 330 VL - 14 IS - 3 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Registries KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- epidemiology KW - Leukemia, Lymphocytic, Chronic, B-Cell -- epidemiology KW - Leukemia, Myeloid, Acute -- epidemiology KW - Humans KW - Leukemia, Myeloid, Acute -- etiology KW - Leukemia, Lymphocytic, Chronic, B-Cell -- etiology KW - Occupations KW - Male KW - Sweden KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- etiology KW - Industry KW - Leukemia -- epidemiology KW - Occupational Diseases -- etiology KW - Occupational Diseases -- epidemiology KW - Leukemia -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78535865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Leukemias+and+occupation+in+Sweden%3A+a+registry-based+analysis.&rft.au=Linet%2C+M+S%3BMalker%2C+H+S%3BMcLaughlin%2C+J+K%3BWeiner%2C+J+A%3BStone%2C+B+J%3BBlot%2C+W+J%3BEricsson%2C+J+L%3BFraumeni%2C+J+F&rft.aulast=Linet&rft.aufirst=M&rft.date=1988-01-01&rft.volume=14&rft.issue=3&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-02 N1 - Date created - 1988-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intestinal cancer induced by N-nitroso compounds. AN - 78517367; 3055229 AB - Several N-nitroso compounds induce tumors of the colon, and some induce tumors in other parts of the intestinal tract as well. The nitrosamines that induce colon tumors are beta oxidized n-propyl-nitrosamines. These require metabolic activation, as do 1,2-dimethylhydrazine, azomethane, and azoxymethane, another group of colon carcinogens. Several nitrosoalkylureas induce tumors in rat colons after oral administration, although the monoalkylnitrosoureas are fairly unstable and might not be expected to reach the colon. However, monoalkylnitrosoureas are equally effective with the much more stable dialkylnitrosoureas. Although nitrosomethylurea did not induce colon tumors under these conditions, nitrosoethylurea did, together with nitrosodiethylurea and other nitrosoethylalkylureas. Nitroso-n-butyl-, n-amyl-, n-hexyl-urea, and nitrosohydroxyethylurea also induced colon tumors, but the last, like nitrosoethylurea, also induced tumors of the duodenum and ileum. In most of these experiments male rats were more susceptible to induction of intestinal tumors than female rats. An explanation for the differences between these compounds of similar structure might be found in variations in their ability to alkylate DNA in intestinal cells, or in differences in stability of the alkylated product between the compounds. The physical properties of the compounds might also modulate the process of carcinogenesis, however. JF - Toxicologic pathology AU - Lijinsky, W AD - NCI-Frederick Cancer Research Facility, BRI-Basic Research Program, Maryland 21701. Y1 - 1988 PY - 1988 DA - 1988 SP - 198 EP - 204 VL - 16 IS - 2 SN - 0192-6233, 0192-6233 KW - Carcinogens KW - 0 KW - Nitroso Compounds KW - Nitrosourea Compounds KW - Index Medicus KW - Rats KW - Animals KW - Intestinal Neoplasms -- pathology KW - Intestinal Neoplasms -- chemically induced KW - Nitrosourea Compounds -- toxicity KW - Organ Specificity KW - Male KW - Female KW - Cricetinae KW - Alkylation KW - Nitroso Compounds -- toxicity KW - Colonic Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78517367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Intestinal+cancer+induced+by+N-nitroso+compounds.&rft.au=Lijinsky%2C+W&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1988-01-01&rft.volume=16&rft.issue=2&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-15 N1 - Date created - 1988-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human immunodeficiency virus as a possible cofactor in the development of fulminant hepatitis B in intravenous drug abusers. AN - 78510976; 3183532 AB - Fulminant hepatitis B virus (HBV) infection is often attributable to co-infection with the delta agent. However, delta produces a variable pattern of illness in HBsAg-positive addicts. It is often not detectable in fulminant cases of hepatitis B, and other cofactors have been conjectured regarding the pathogenesis of fulminant HBV disease. We present the case of an intravenous drug abuser with severe hepatitis B and concomitant infection with human immunodeficiency virus. We conclude that dual infection with these two viruses may be a factor in the development of fulminant hepatitis B in i.v. drug abusers, and might account for the atypical clinical course often observed. JF - Journal of medicine AU - Lange, W R AU - Moore, J D AU - Cibull, M L AU - Brutsche, R L AD - Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224. Y1 - 1988 PY - 1988 DA - 1988 SP - 203 EP - 214 VL - 19 IS - 3-4 SN - 0025-7850, 0025-7850 KW - Index Medicus KW - AIDS/HIV KW - Injections, Intravenous KW - Humans KW - Adult KW - Female KW - Hepatitis B -- microbiology KW - HIV -- physiology KW - HIV Seropositivity KW - Substance-Related Disorders KW - Hepatitis B -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78510976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicine&rft.atitle=Human+immunodeficiency+virus+as+a+possible+cofactor+in+the+development+of+fulminant+hepatitis+B+in+intravenous+drug+abusers.&rft.au=Lange%2C+W+R%3BMoore%2C+J+D%3BCibull%2C+M+L%3BBrutsche%2C+R+L&rft.aulast=Lange&rft.aufirst=W&rft.date=1988-01-01&rft.volume=19&rft.issue=3-4&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicine&rft.issn=00257850&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-12 N1 - Date created - 1988-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Magnesium counteracts nickel-induced suppression of T lymphocyte response to concanavalin A. AN - 78506423; 3263555 AB - Effects of nickel and magnesium on the responsiveness of BALB/c mouse spleen lymphocytes to a mitogen, concanavalin A (Con A), were studied using the in vitro 3H-thymidine (TdR) incorporation test. Nickel chloride (NiCl2) and nickel subsulfide (Ni3S2) were found to suppress this response. The control level of TdR incorporation from a magnesium-free medium containing 0.625 microgram Con A/ml into trichloroacetic-acid-precipitable nucleoprotein was depressed by both nickel compounds in a dose-dependent manner to 3% of its original value by 0.25 mumol NiCl2/ml or 0.33 mumol Ni3S2/ml (5 micron particles). Magnesium stimulated TdR incorporation up to a maximum of 200% of the control level at concentrations greater than 2.0 mumol MgCl2/ml. Also, gradual increase of magnesium concentration in the culture medium up to 2.0 mumol/ml attenuated the effects of nickel, restoring the lymphocyte response to Con A to 43% of the control level at 0.25 mumol NiCl2/ml or to 30% at 0.33 mumol Ni3S2/ml. Higher concentrations of magnesium did not further enhance this responsiveness. These data suggest that the effect of magnesium upon early cellular response to nickel observed in vivo [Kasprzak et al.: Carcinogenesis 6: 1161-1166, 1985], which eventually results in a decreased tumor incidence, may be due in part to antagonism by magnesium of nickel suppression of the activity of T lymphocytes. JF - Magnesium AU - Kasprzak, K S AU - Kiser, R F AU - Weislow, O S AD - Inorganic Carcinogenesis Section, National Cancer Institute, Frederick, Md. Y1 - 1988 PY - 1988 DA - 1988 SP - 166 EP - 172 VL - 7 IS - 3 SN - 0252-1156, 0252-1156 KW - magnesium carbonate KW - 0E53J927NA KW - Concanavalin A KW - 11028-71-0 KW - nickel subsulfide KW - 12035-72-2 KW - nickel chloride KW - 696BNE976J KW - Nickel KW - 7OV03QG267 KW - DNA KW - 9007-49-2 KW - Magnesium KW - I38ZP9992A KW - Index Medicus KW - Animals KW - Drug Interactions KW - Spleen -- cytology KW - Mice KW - Mice, Inbred BALB C KW - DNA -- biosynthesis KW - Female KW - T-Lymphocytes -- metabolism KW - Nickel -- pharmacology KW - Magnesium -- pharmacology KW - T-Lymphocytes -- drug effects KW - Concanavalin A -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78506423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnesium&rft.atitle=Magnesium+counteracts+nickel-induced+suppression+of+T+lymphocyte+response+to+concanavalin+A.&rft.au=Kasprzak%2C+K+S%3BKiser%2C+R+F%3BWeislow%2C+O+S&rft.aulast=Kasprzak&rft.aufirst=K&rft.date=1988-01-01&rft.volume=7&rft.issue=3&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Magnesium&rft.issn=02521156&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-22 N1 - Date created - 1988-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Detection of antibodies to Herpesvirus saimiri late antigens in human sera. AN - 78502400; 2846466 AB - One hundred fifty sera from handlers of squirrel monkeys and 100 sera from individuals who had never handled monkeys were tested by immunofluorescence for antibodies reactive to structural proteins of Herpesvirus saimiri (HVS). Eleven (7.3%) of the occupationally exposed group and 4 (4%) of the noncontact group were seropositive for HVS by immunofluorescence assay, and 10 of these 15 (6.7 and 2%, respectively) were also seropositive for either the major glycoprotein (140 kD) or the major capsid protein (160 kD) of HVS by radioimmunoprecipitation assay. Two sera from handlers of squirrel monkeys, however, recognized many different HVS structural antigens by immunoprecipitation, and it seems unlikely that they could also be cross-reactive antibodies. Since these two sera did not contain antibodies to HVS early antigens or to the nonstructural antigens present in infected owl monkey kidney cells, and follow-up sera collected from the same individuals several months later were negative for antibodies to HVS, these individuals do not appear to have been infected by the virus. The risk that HVS poses to humans appears to be very low. JF - Intervirology AU - Ablashi, D V AU - Dahlberg, J E AU - Cannon, G B AU - Fischetti, G AU - Loeb, W AU - Hinds, W AU - Schatte, C AU - Levine, P H AD - Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Md 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 217 EP - 226 VL - 29 IS - 4 SN - 0300-5526, 0300-5526 KW - Antibodies, Viral KW - 0 KW - Antigens, Viral KW - Viral Proteins KW - Viral Structural Proteins KW - Index Medicus KW - Viral Proteins -- immunology KW - Animals KW - Humans KW - Herpesviridae Infections -- etiology KW - Occupational Diseases -- etiology KW - Animal Husbandry KW - Precipitin Tests KW - Lymphocytes -- microbiology KW - Fluorescent Antibody Technique KW - Saimiri -- microbiology KW - Antibodies, Viral -- isolation & purification KW - Herpesvirus 2, Saimiriine -- isolation & purification KW - Herpesvirus 2, Saimiriine -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78502400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intervirology&rft.atitle=Detection+of+antibodies+to+Herpesvirus+saimiri+late+antigens+in+human+sera.&rft.au=Ablashi%2C+D+V%3BDahlberg%2C+J+E%3BCannon%2C+G+B%3BFischetti%2C+G%3BLoeb%2C+W%3BHinds%2C+W%3BSchatte%2C+C%3BLevine%2C+P+H&rft.aulast=Ablashi&rft.aufirst=D&rft.date=1988-01-01&rft.volume=29&rft.issue=4&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Intervirology&rft.issn=03005526&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-20 N1 - Date created - 1988-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Studies of cancer among the Japanese A-bomb survivors. AN - 78501193; 3179774 AB - Studies of cancer among the Japanese survivors of the A-bombs dropped on Nagasaki and Hiroshima are the major source of information on radiation carcinogenesis in humans. They have already made important contributions to the estimation of the risk of radiation-induced cancer and to our understanding of key factors influencing risk, especially tissue sensitivity, age at exposure, and the temporal distribution of radiogenic cancers. The size of the exposed population still surviving virtually guarantees the continued productivity of the research conducted in Hiroshima and Nagasaki. It should not be supposed, however, that these studies will ever provide all the information needed for radiation protection standards or risk estimation. The experience of the A-bomb survivors simply does not include all important aspects of radiation exposure for which information is needed. Moreover, despite the size of the sample remaining under study, it is most unlikely that direct, empirical estimates can be made that will remove the necessity for dependence upon mathematical models to derive estimates of risk in the low-dose region. JF - Cancer investigation AU - Beebe, G W AD - Clinical Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 417 EP - 426 VL - 6 IS - 4 SN - 0735-7907, 0735-7907 KW - Index Medicus KW - Infant KW - Risk KW - Radiation Dosage KW - Age Factors KW - Humans KW - Adult KW - Infant, Newborn KW - Middle Aged KW - Child KW - Adolescent KW - Time Factors KW - Japan KW - Child, Preschool KW - Nuclear Warfare KW - Neoplasms, Radiation-Induced -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78501193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+investigation&rft.atitle=Studies+of+cancer+among+the+Japanese+A-bomb+survivors.&rft.au=Beebe%2C+G+W&rft.aulast=Beebe&rft.aufirst=G&rft.date=1988-01-01&rft.volume=6&rft.issue=4&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Cancer+investigation&rft.issn=07357907&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-25 N1 - Date created - 1988-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Toxicity and carcinogenicity of rotenone given in the feed to F344/N rats and B6C3F1 mice for up to two years. AN - 78496696; 3181037 AB - Toxicity and carcinogenicity studies of rotenone were conducted in F344/N rats and B6C3F1 mice. Groups of 50 rats and 50 mice of each sex were given rotenone in their diet for up to 103 weeks. The doses were 0, 38, and 75 ppm for rats and 0, 600, and 1,200 ppm for mice. Reduction in body weight gain occurred in male and female mice given rotenone. No effects on survival were observed for rats of either sex or female mice. Survival of male mice at 1,200 ppm was significantly greater than that of controls (47/50 vs. 29/50). There were no observed nonneoplastic effects due to rotenone, and for male and female mice no neoplasms were induced by rotenone. Parathyroid adenomas occurred at a higher incidence (4/44) in male rats at 75 ppm than in the controls (1/41). Because these tumors are rare (historical rate in NTP studies is 0.3%), the increase in the incidence of these benign tumors may have been related to rotenone administration. Hepatocellular neoplasms were reduced (p less than 0.01) in males receiving 1,200 ppm 1/50 relative to controls 12/47. Because this low rate of liver tumors is unusual in male B6C3F1 mice, this decrease was considered to be related to rotenone administration. JF - Drug and chemical toxicology AU - Abdo, K M AU - Eustis, S L AU - Haseman, J AU - Huff, J E AU - Peters, A AU - Persing, R AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 225 EP - 235 VL - 11 IS - 3 SN - 0148-0545, 0148-0545 KW - Carcinogens KW - 0 KW - Rotenone KW - 03L9OT429T KW - Index Medicus KW - Eating -- drug effects KW - Animals KW - Soft Tissue Neoplasms -- pathology KW - Sex Factors KW - Mice KW - Parathyroid Neoplasms -- pathology KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Soft Tissue Neoplasms -- chemically induced KW - Body Weight -- drug effects KW - Parathyroid Neoplasms -- chemically induced KW - Diet KW - Time Factors KW - Female KW - Male KW - Rotenone -- toxicity KW - Rotenone -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78496696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+chemical+toxicology&rft.atitle=Toxicity+and+carcinogenicity+of+rotenone+given+in+the+feed+to+F344%2FN+rats+and+B6C3F1+mice+for+up+to+two+years.&rft.au=Abdo%2C+K+M%3BEustis%2C+S+L%3BHaseman%2C+J%3BHuff%2C+J+E%3BPeters%2C+A%3BPersing%2C+R&rft.aulast=Abdo&rft.aufirst=K&rft.date=1988-01-01&rft.volume=11&rft.issue=3&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Drug+and+chemical+toxicology&rft.issn=01480545&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-02 N1 - Date created - 1988-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mechanisms of metal-induced renal cell injury: roles of high-affinity metal-binding proteins. AN - 78487940; 3053040 JF - Contributions to nephrology AU - Fowler, B A AD - National Institute of Environmental Health Sciences, Research Triangle Park, N.C. Y1 - 1988 PY - 1988 DA - 1988 SP - 83 EP - 92 VL - 64 SN - 0302-5144, 0302-5144 KW - Carrier Proteins KW - 0 KW - Metals KW - lead-binding proteins KW - Metallothionein KW - 9038-94-2 KW - Index Medicus KW - Animals KW - Carrier Proteins -- metabolism KW - Humans KW - Microscopy, Electron KW - Metallothionein -- metabolism KW - Kidney -- metabolism KW - Metals -- adverse effects KW - Kidney -- drug effects KW - Metals -- metabolism KW - Kidney -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78487940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contributions+to+nephrology&rft.atitle=Mechanisms+of+metal-induced+renal+cell+injury%3A+roles+of+high-affinity+metal-binding+proteins.&rft.au=Fowler%2C+B+A&rft.aulast=Fowler&rft.aufirst=B&rft.date=1988-01-01&rft.volume=64&rft.issue=&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Contributions+to+nephrology&rft.issn=03025144&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-12 N1 - Date created - 1988-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Adolescent alcohol and drug abuse and its consequences--an overview. AN - 78476041; 3052038 JF - The American journal of drug and alcohol abuse AU - Czechowicz, D AD - Office of Science, National Institute on Drug Abuse, Rockville, Maryland 20857. Y1 - 1988 PY - 1988 DA - 1988 SP - 189 EP - 197 VL - 14 IS - 2 SN - 0095-2990, 0095-2990 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - United States KW - Risk Factors KW - Humans KW - Accidents -- mortality KW - Marijuana Abuse -- epidemiology KW - Child KW - Adolescent KW - Adolescent Behavior KW - Alcoholism -- epidemiology KW - Substance-Related Disorders -- complications KW - Alcoholism -- complications KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78476041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Adolescent+alcohol+and+drug+abuse+and+its+consequences--an+overview.&rft.au=Czechowicz%2C+D&rft.aulast=Czechowicz&rft.aufirst=D&rft.date=1988-01-01&rft.volume=14&rft.issue=2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-03 N1 - Date created - 1988-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Smoking as an issue in alcohol and drug abuse treatment. AN - 78474299; 3051913 AB - Little attention has been given to the role of tobacco dependence within alcohol and drug abuse treatment. Yet, smoking behavior appears to be interrelated with the use of alcohol and other drugs. This interrelationship is explored, and the role of smoking cessation within alcohol and drug abuse treatment is considered. Areas for future research on this topic are identified. Addictive disorders are generally thought to include alcohol abuse, drug abuse, smoking, overeating, and, sometimes, gambling and caffeine dependence. While some attention has been paid to the common etiological roots of various addictive disorders, relatively little systematic attention has been paid to commonalities in their treatment and especially to the treatment of multiple disorders in the same individuals. The one significant exception is alcohol abuse and drug abuse. Of the other addictive disorders, tobacco dependence has been most closely interrelated with alcohol and drug abuse. Yet, little attention has been given to tobacco dependence within alcohol and drug abuse treatment. This paper will focus on smoking in relationship with alcohol and drug abuse, and will consider the possible role of smoking cessation treatment within the context of alcohol and drug abuse treatment. First, background regarding the interrelationship of alcohol and drug abuse is explored. Then, the relationship of smoking with other substance use is considered, followed by a review of special concerns related to smoking among alcohol and drug abuse clients. Next, the current status of smoking cessation within alcohol and drug abuse treatment is addressed. Finally, implications are considered. JF - Addictive behaviors AU - Battjes, R J AD - National Institute on Drug Abuse, Rockville, MD 20857. Y1 - 1988 PY - 1988 DA - 1988 SP - 225 EP - 230 VL - 13 IS - 3 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Combined Modality Therapy KW - Humans KW - Alcoholism -- rehabilitation KW - Smoking -- therapy KW - Smoking -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78474299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Smoking+as+an+issue+in+alcohol+and+drug+abuse+treatment.&rft.au=Battjes%2C+R+J&rft.aulast=Battjes&rft.aufirst=R&rft.date=1988-01-01&rft.volume=13&rft.issue=3&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-16 N1 - Date created - 1988-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Benzodiazepine, barbiturate, ethanol and hypnotic steroid hormone modulation of GABA-mediated chloride ion transport in rat brain synaptoneurosomes. AN - 78472075; 2902744 JF - Advances in biochemical psychopharmacology AU - Morrow, A L AU - Suzdak, P D AU - Paul, S M AD - Section on Molecular Pharmacology, National Institute of Mental Health, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 247 EP - 261 VL - 45 SN - 0065-2229, 0065-2229 KW - Anti-Anxiety Agents KW - 0 KW - Barbiturates KW - Chlorides KW - Hypnotics and Sedatives KW - Receptors, GABA-A KW - Steroids KW - Benzodiazepines KW - 12794-10-4 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Synaptosomes -- drug effects KW - Brain -- drug effects KW - In Vitro Techniques KW - Steroids -- pharmacology KW - Brain -- metabolism KW - Drug Synergism KW - Synaptosomes -- metabolism KW - Male KW - Anti-Anxiety Agents -- pharmacology KW - Receptors, GABA-A -- physiology KW - Ethanol -- pharmacology KW - Barbiturates -- pharmacology KW - Receptors, GABA-A -- drug effects KW - Chlorides -- metabolism KW - Hypnotics and Sedatives -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78472075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+biochemical+psychopharmacology&rft.atitle=Benzodiazepine%2C+barbiturate%2C+ethanol+and+hypnotic+steroid+hormone+modulation+of+GABA-mediated+chloride+ion+transport+in+rat+brain+synaptoneurosomes.&rft.au=Morrow%2C+A+L%3BSuzdak%2C+P+D%3BPaul%2C+S+M&rft.aulast=Morrow&rft.aufirst=A&rft.date=1988-01-01&rft.volume=45&rft.issue=&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Advances+in+biochemical+psychopharmacology&rft.issn=00652229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-23 N1 - Date created - 1988-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Rapid induction of lorazepam dependence and reversal with flumazenil. AN - 78461869; 3139949 AB - Benzodiazepine tolerance, dependence and withdrawal are well established clinical entities although the pharmacological basis for these are still unclear. Recent data suggest that the primary event may be a change in efficacy at the benzodiazepine receptor. The present study demonstrates the rapid development of tolerance and dependence to lorazepam, defines its pharmacology in more detail, and shows that it may be rapidly reversed by treatment with the benzodiazepine antagonist flumazenil. These observations argue in favour of a receptor efficacy change underlying benzodiazepine tolerance and withdrawal and suggest a potential pharmacological treatment for this common and disabling clinical problem. JF - Life sciences AU - Nutt, D J AU - Costello, M J AD - Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 1045 EP - 1053 VL - 43 IS - 13 SN - 0024-3205, 0024-3205 KW - Carbolines KW - 0 KW - Flumazenil KW - 40P7XK9392 KW - FG 7142 KW - 60PO70N1BP KW - beta-carboline-3-carboxylic acid methyl ester KW - I2A008F6YL KW - Lorazepam KW - O26FZP769L KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Seizures -- physiopathology KW - Mice KW - Carbolines -- pharmacology KW - Male KW - Substance-Related Disorders -- physiopathology KW - Flumazenil -- therapeutic use KW - Substance-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78461869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Rapid+induction+of+lorazepam+dependence+and+reversal+with+flumazenil.&rft.au=Nutt%2C+D+J%3BCostello%2C+M+J&rft.aulast=Nutt&rft.aufirst=D&rft.date=1988-01-01&rft.volume=43&rft.issue=13&rft.spage=1045&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-09 N1 - Date created - 1988-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An introduction to compulsory treatment for drug abuse: clinical practice and research. AN - 78458651; 3140026 JF - NIDA research monograph AU - Leukefeld, C G AU - Tims, F M AD - National Institute on Drug Abuse, Rockville, MD 20857. Y1 - 1988 PY - 1988 DA - 1988 SP - 1 EP - 7 VL - 86 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - AIDS/HIV KW - United States KW - Injections, Intravenous KW - Humans KW - Acquired Immunodeficiency Syndrome -- transmission KW - Substance-Related Disorders -- therapy KW - Commitment of Mentally Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78458651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=An+introduction+to+compulsory+treatment+for+drug+abuse%3A+clinical+practice+and+research.&rft.au=Leukefeld%2C+C+G%3BTims%2C+F+M&rft.aulast=Leukefeld&rft.aufirst=C&rft.date=1988-01-01&rft.volume=86&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-08 N1 - Date created - 1988-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Range of toxicity of topical cysteamine in rabbit eyes. AN - 78458136; 3171336 AB - Cysteamine eye drops in concentrations from 0.1% to 10% were tested in albino rabbits in both short and long-term experiments. Toxicity, consisting of an inflammatory response, was proportional to the cysteamine concentration and absent at concentrations at or below 0.5%. JF - Journal of ocular pharmacology AU - Jain, S AU - Kuwabara, T AU - Gahl, W A AU - Kaiser-Kupfer, M I AD - Clinical Branch, National Eye Institute, Bethesda, Maryland. Y1 - 1988 PY - 1988 DA - 1988 SP - 127 EP - 131 VL - 4 IS - 2 SN - 8756-3320, 8756-3320 KW - Ophthalmic Solutions KW - 0 KW - Cysteamine KW - 5UX2SD1KE2 KW - Index Medicus KW - Animals KW - Rabbits KW - Male KW - Female KW - Cysteamine -- toxicity KW - Cysteamine -- administration & dosage KW - Eye -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78458136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+ocular+pharmacology&rft.atitle=Range+of+toxicity+of+topical+cysteamine+in+rabbit+eyes.&rft.au=Jain%2C+S%3BKuwabara%2C+T%3BGahl%2C+W+A%3BKaiser-Kupfer%2C+M+I&rft.aulast=Jain&rft.aufirst=S&rft.date=1988-01-01&rft.volume=4&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Journal+of+ocular+pharmacology&rft.issn=87563320&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-04 N1 - Date created - 1988-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hormone therapy for prostate cancer: results of the Veterans Administration Cooperative Urological Research Group studies. AN - 78458109; 3050535 AB - Between 1960 and 1975, the Veterans Administration Cooperative Urological Research Group conducted a consecutive series of 3 major randomized clinical trials comparing various endocrine treatments for newly diagnosed prostate cancer patients. Six major conclusions concerning hormonal treatment emerged from these studies: 1) increased hazard of cardiovascular death after therapy with 5 mg diethylstilbestrol (DES); 2) orchiectomy plus DES no better than orchiectomy or DES alone; 3) equivalent effect of 1.0 and 5.0 mg DES on cancer; 4) reduced cardiovascular hazard from therapy with 1.0 mg DES; 5) Premarin and Provera no better than 1.0 mg DES at doses studied; 6) decisions about hormone treatment at diagnosis dependent on patient characteristics, mainly age and Gleason grade. In this paper, these studies are reviewed briefly and data are presented to support these conclusions. Some tentative treatment recommendations are proposed. JF - NCI monographs : a publication of the National Cancer Institute AU - Byar, D P AU - Corle, D K AD - Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 165 EP - 170 IS - 7 SN - 0893-2751, 0893-2751 KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Cardiovascular Diseases -- chemically induced KW - Male KW - Orchiectomy KW - Prostatic Neoplasms -- mortality KW - Diethylstilbestrol -- therapeutic use KW - Diethylstilbestrol -- adverse effects KW - Prostatic Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78458109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.atitle=Hormone+therapy+for+prostate+cancer%3A+results+of+the+Veterans+Administration+Cooperative+Urological+Research+Group+studies.&rft.au=Byar%2C+D+P%3BCorle%2C+D+K&rft.aulast=Byar&rft.aufirst=D&rft.date=1988-01-01&rft.volume=&rft.issue=7&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.issn=08932751&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-03 N1 - Date created - 1988-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Basic issues pertaining to the effectiveness of methadone maintenance treatment. AN - 78455786; 3140030 JF - NIDA research monograph AU - Ball, J C AU - Corty, E AD - National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224. Y1 - 1988 PY - 1988 DA - 1988 SP - 178 EP - 191 VL - 86 SN - 1046-9516, 1046-9516 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - United States KW - Humans KW - Criminal Law KW - Counseling KW - Male KW - Methadone -- therapeutic use KW - Heroin Dependence -- rehabilitation KW - Heroin Dependence -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78455786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Basic+issues+pertaining+to+the+effectiveness+of+methadone+maintenance+treatment.&rft.au=Ball%2C+J+C%3BCorty%2C+E&rft.aulast=Ball&rft.aufirst=J&rft.date=1988-01-01&rft.volume=86&rft.issue=&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-08 N1 - Date created - 1988-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Epidemiologic studies--Kaposi's sarcoma vs. opportunistic infections among homosexual men with AIDS. AN - 78455738; 3140024 JF - NIDA research monograph AU - Haverkos, H W AD - Clinical Medicine Branch, National Institute on Drug Abuse, Rockville, MD 20857. Y1 - 1988 PY - 1988 DA - 1988 SP - 96 EP - 105 VL - 83 SN - 1046-9516, 1046-9516 KW - Nitrites KW - 0 KW - Index Medicus KW - AIDS/HIV KW - United States KW - Epidemiologic Methods KW - Nitrites -- adverse effects KW - Humans KW - Surveys and Questionnaires KW - Male KW - Substance-Related Disorders -- epidemiology KW - Opportunistic Infections -- epidemiology KW - Acquired Immunodeficiency Syndrome -- complications KW - Opportunistic Infections -- etiology KW - Acquired Immunodeficiency Syndrome -- epidemiology KW - Sarcoma, Kaposi -- epidemiology KW - Homosexuality KW - Sarcoma, Kaposi -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78455738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Epidemiologic+studies--Kaposi%27s+sarcoma+vs.+opportunistic+infections+among+homosexual+men+with+AIDS.&rft.au=Haverkos%2C+H+W&rft.aulast=Haverkos&rft.aufirst=H&rft.date=1988-01-01&rft.volume=83&rft.issue=&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-09 N1 - Date created - 1988-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 3-Ethoxy-beta-carboline: a high affinity benzodiazepine receptor ligand with partial inverse agonist properties. AN - 78455736; 2845211 AB - 3-Ethoxy-beta-carboline binds with high affinity to benzodiazepine receptors in the central nervous system (Ki approximately equal to 10.1, 15.3, and 25.3 nM in rat cerebellum, cerebral cortex, and hippocampus, respectively). This compound has pharmacological actions reminiscent of benzodiazepine receptor partial inverse agonists such as FG 7142 and 3-carboethoxy-beta-carboline. Thus, while not a convulsant, 3-ethoxy-beta-carboline potentiated the convulsant actions of pentylenetetrazole in mice. Furthermore, this compound reduced both the time spent and the total entries in the open arms of an elevated plus maze and also inhibited stress-induced ulcer formation, effects that are also observed with benzodiazepine receptor inverse agonists. These findings suggest that 3-ethoxy-beta-carboline is a partial inverse agonist at benzodiazepine receptors which may prove useful for in vivo studies since it has a higher affinity for benzodiazepine receptors and better solubility than the commonly used partial inverse agonist FG 7142. Furthermore, 3-ethoxy-beta-carboline appears to be less vulnerable to metabolic degradation than ester analogs with a similar pharmacological profile such as 3-carboethoxy-beta-carboline. JF - Life sciences AU - Trullas, R AU - Ginter, H AU - Jackson, B AU - Skolnick, P AU - Allen, M S AU - Hagen, T J AU - Cook, J M AD - Laboratory of Neuroscience, NIDDK, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 1189 EP - 1197 VL - 43 IS - 15 SN - 0024-3205, 0024-3205 KW - Carbolines KW - 0 KW - Convulsants KW - Ligands KW - Receptors, GABA-A KW - Flumazenil KW - 40P7XK9392 KW - FG 7142 KW - 60PO70N1BP KW - 3-ethoxy-beta-carboline KW - 91985-81-8 KW - Index Medicus KW - Seizures -- chemically induced KW - Animals KW - Solubility KW - Flumazenil -- metabolism KW - Cerebral Cortex -- metabolism KW - Stress, Psychological -- physiopathology KW - Convulsants -- pharmacology KW - Hippocampus -- metabolism KW - Peptic Ulcer -- physiopathology KW - Cerebellum -- metabolism KW - Rats KW - Binding, Competitive KW - In Vitro Techniques KW - Drug Synergism KW - Carbolines -- physiology KW - Receptors, GABA-A -- metabolism KW - Brain -- metabolism KW - Carbolines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78455736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=3-Ethoxy-beta-carboline%3A+a+high+affinity+benzodiazepine+receptor+ligand+with+partial+inverse+agonist+properties.&rft.au=Trullas%2C+R%3BGinter%2C+H%3BJackson%2C+B%3BSkolnick%2C+P%3BAllen%2C+M+S%3BHagen%2C+T+J%3BCook%2C+J+M&rft.aulast=Trullas&rft.aufirst=R&rft.date=1988-01-01&rft.volume=43&rft.issue=15&rft.spage=1189&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-17 N1 - Date created - 1988-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nitrite inhalants: contemporary patterns of abuse. AN - 78452812; 3140023 JF - NIDA research monograph AU - Lange, W R AU - Dax, E M AU - Haertzen, C A AU - Snyder, F R AU - Jaffe, J H AD - Addiction Research Center, National Institute on Drug Abuse, Francis Scott Key Medical Center, Baltimore, MD 21224. Y1 - 1988 PY - 1988 DA - 1988 SP - 86 EP - 95 VL - 83 SN - 1046-9516, 1046-9516 KW - Nitrites KW - 0 KW - Index Medicus KW - United States KW - Baltimore KW - Humans KW - Adult KW - Homosexuality KW - Adolescent KW - Administration, Inhalation KW - Male KW - Female KW - Nitrites -- administration & dosage KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78452812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Nitrite+inhalants%3A+contemporary+patterns+of+abuse.&rft.au=Lange%2C+W+R%3BDax%2C+E+M%3BHaertzen%2C+C+A%3BSnyder%2C+F+R%3BJaffe%2C+J+H&rft.aulast=Lange&rft.aufirst=W&rft.date=1988-01-01&rft.volume=83&rft.issue=&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-09 N1 - Date created - 1988-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Compulsory treatment: a review of findings. AN - 78451439; 3140033 JF - NIDA research monograph AU - Leukefeld, C G AU - Tims, F M AD - National Institute on Drug Abuse, Rockville, MD 20857. Y1 - 1988 PY - 1988 DA - 1988 SP - 236 EP - 251 VL - 86 SN - 1046-9516, 1046-9516 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - United States KW - Methadone -- therapeutic use KW - Length of Stay KW - Humans KW - Cost-Benefit Analysis KW - Adult KW - Male KW - Substance-Related Disorders -- therapy KW - Jurisprudence KW - Criminal Law KW - Substance-Related Disorders -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78451439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Compulsory+treatment%3A+a+review+of+findings.&rft.au=Leukefeld%2C+C+G%3BTims%2C+F+M&rft.aulast=Leukefeld&rft.aufirst=C&rft.date=1988-01-01&rft.volume=86&rft.issue=&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-08 N1 - Date created - 1988-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: quality-control guidelines and response categories. AN - 78425752; 3416839 AB - A data-based approach to formulating quality-control criteria for the mouse lymphoma cell forward mutation assay is described. Quality-control guidelines for solvent controls, positive controls, and compound-treated cultures were developed based on analysis of over 800 experiments. Frequency distributions of experimental parameters of control cultures, such as mutant frequencies, cloning efficiencies, and suspension growths, were examined. Cloning efficiency and relative total growth affected the variability only when the test chemical was highly toxic. This information was used to generate the quality-control criteria, which were applied to an experiment before it was evaluated for a response. The response categories for classifying the effect of test chemicals on the assay system are defined in terms of (1) the statistically significant differences in average mutant frequency between solvent control cultures and cultures exposed to a chemical and (2) the trend of the dose-related responses. JF - Environmental and molecular mutagenesis AU - Caspary, W J AU - Lee, Y J AU - Poulton, S AU - Myhr, B C AU - Mitchell, A D AU - Rudd, C J AD - Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. Y1 - 1988 PY - 1988 DA - 1988 SP - 19 EP - 36 VL - 12 Suppl 13 SN - 0893-6692, 0893-6692 KW - Mutagens KW - 0 KW - Solvents KW - Index Medicus KW - Evaluation Studies as Topic KW - Animals KW - Tumor Cells, Cultured KW - Solvents -- standards KW - Mice KW - Leukemia L5178 KW - Quality Control KW - Mutation KW - Mutagenicity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78425752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Evaluation+of+the+L5178Y+mouse+lymphoma+cell+mutagenesis+assay%3A+quality-control+guidelines+and+response+categories.&rft.au=Caspary%2C+W+J%3BLee%2C+Y+J%3BPoulton%2C+S%3BMyhr%2C+B+C%3BMitchell%2C+A+D%3BRudd%2C+C+J&rft.aulast=Caspary&rft.aufirst=W&rft.date=1988-01-01&rft.volume=12+Suppl+13&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-21 N1 - Date created - 1988-10-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: interlaboratory reproducibility and assessment. AN - 78421086; 3416840 AB - The L5178Y mouse lymphoma cell mutagenesis assay is used to detect the mutagenic activity of chemicals in a mammalian cell system. To evaluate this assay we compared the results of assays performed independently on 63 chemicals by laboratories at SRI International and Litton Bionetics, Inc. The two laboratories used similar protocols. The solvent and positive control mutant frequencies and cloning efficiencies obtained by the two laboratories were similar, which justified the use of the same quality-control criteria and analytical procedures for analyzing the results from both laboratories. The rate of concordance between the two laboratories was 92% for tests in the absence of S9 activation and 95% for tests in its presence. The results of the assays agreed for 57 of the 63 chemicals; three chemicals could not be compared because there were questionable calls in at least one of the laboratories; the results disagreed for the three remaining chemicals. The concordance rate for these overall assay evaluations was 95%. The interlaboratory concordance rates were similar to concordance rates for replicate experiments within the laboratories (96% at LBI, 94% at SRI). The mouse lymphoma cell mutagenicity results are concordant with the rodent chronic assay results in 78% of 50 chemicals and with the Salmonella assay results in 79% of 56 chemicals. Fifteen carcinogens were examined for genotoxic effects in mouse lymphoma, Salmonella, Chinese hamster ovary (CHO) chromosomal aberration, and CHO sister chromatid exchange assay. Eight of these were positive in all four assays. Of the seven noncarcinogens that were tested in these four assays, none was negative in all four. The main conclusion to be drawn from this study is that the mouse lymphoma cell forward mutation assay, as performed and evaluated in this study, detects chemical mutagenicity in a manner that is highly consistent with other genetic endpoints as well as rodent carcinogenicity studies. Thus the assay quality control and response criteria established in this study led not only to a high degree of reproducibility but also to an apparently reliable detection of mutagenic activity. JF - Environmental and molecular mutagenesis AU - Caspary, W J AU - Daston, D S AU - Myhr, B C AU - Mitchell, A D AU - Rudd, C J AU - Lee, P S AD - Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. Y1 - 1988 PY - 1988 DA - 1988 SP - 195 EP - 229 VL - 12 Suppl 13 SN - 0893-6692, 0893-6692 KW - Mutagens KW - 0 KW - Index Medicus KW - Evaluation Studies as Topic KW - Clone Cells KW - Animals KW - Tumor Cells, Cultured KW - Cell Count KW - Dose-Response Relationship, Drug KW - Chemical Precipitation KW - Predictive Value of Tests KW - Mice KW - Leukemia L5178 KW - Quality Control KW - Mutation KW - Mutagenicity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78421086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Evaluation+of+the+L5178Y+mouse+lymphoma+cell+mutagenesis+assay%3A+interlaboratory+reproducibility+and+assessment.&rft.au=Caspary%2C+W+J%3BDaston%2C+D+S%3BMyhr%2C+B+C%3BMitchell%2C+A+D%3BRudd%2C+C+J%3BLee%2C+P+S&rft.aulast=Caspary&rft.aufirst=W&rft.date=1988-01-01&rft.volume=12+Suppl+13&rft.issue=&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-21 N1 - Date created - 1988-10-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lack of a relationship between immune function and chemically induced hepatocarcinogenesis in B6C3F1 mice. AN - 78406695; 3262012 AB - The relationship between immune function and chemically induced hepatocarcinogenesis was studied employing an in vivo murine model. Neonatal B6C3F1 mice were given a single carcinogenic dose of diethylnitrosamine (DEN) and the time-response kinetics for the early (foci of alteration) and late (adenomas/carcinomas) phases of hepatocellular carcinogenesis were compared to changes in hematopoiesis and immune functions associated with immune surveillance and natural resistance. Increases in hematopoiesis occurred just prior to or concurrent with the appearance of hepatocellular carcinomas, while increased macrophage and natural killer cell cytotoxicity and suppression of cell-mediated immunity occurred following tumor appearance and progressed with increasing tumor burden. Neither immunological nor hematopoietic changes were associated with early phases of hepatocarcinogenesis, as monitored by the appearance of altered hepatocellular foci. Although changes in hematopoiesis may represent an early indicator for hepatocarcinogenesis in the mouse tumor model, the data suggest that altered immune surveillance and natural resistance are not factors in the development of chemically induced hepatocellular tumors, and the changes in immune function are probably secondary to tumor development. JF - Cancer immunology, immunotherapy : CII AU - Germolec, D R AU - Maronpot, R R AU - Ackermann, M F AU - Vore, S J AU - Dittrich, K AU - Rosenthal, G J AU - Luster, M I AD - Systemic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 121 EP - 127 VL - 27 IS - 2 SN - 0340-7004, 0340-7004 KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Mice KW - Hematopoiesis KW - T-Lymphocytes -- immunology KW - Male KW - Killer Cells, Natural -- immunology KW - Female KW - Liver Neoplasms, Experimental -- immunology KW - Liver Neoplasms, Experimental -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78406695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.atitle=Lack+of+a+relationship+between+immune+function+and+chemically+induced+hepatocarcinogenesis+in+B6C3F1+mice.&rft.au=Germolec%2C+D+R%3BMaronpot%2C+R+R%3BAckermann%2C+M+F%3BVore%2C+S+J%3BDittrich%2C+K%3BRosenthal%2C+G+J%3BLuster%2C+M+I&rft.aulast=Germolec&rft.aufirst=D&rft.date=1988-01-01&rft.volume=27&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.issn=03407004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-24 N1 - Date created - 1988-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Calcium agonist (BayK 8644) augments voltage-sensitive calcium currents but not synaptic transmission in cultured mouse spinal cord neurons. AN - 78403207; 2458275 AB - The effects of the calcium agonist, BayK 8644, and other agents upon voltage-dependent calcium conductance (VSCC) and evoked synaptic activity were studied in cultured mouse spinal cord and dorsal root ganglion neurons. As expected, BayK 8644 increased the VSCC corresponding to L channels. It had relatively little effect on evoked synaptic activity; the small but statistically significant effect that was noted was a decrease. Nitrendipine had either no effect or an increase with no statistically significant effect being seen with regard to synaptic activity over the population sampled. An increased extracellular Ca++ concentration increased both VSCC and synaptic activity. We conclude that VSCC with L channel properties are probably not involved in transmitter release produced by action potentials in the central synapses occurring in the dissociated mouse spinal cord cell culture system. JF - Experimental brain research AU - Yu, C AU - Jia, M AU - Litzinger, M AU - Nelson, P G AD - Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 467 EP - 474 VL - 71 IS - 3 SN - 0014-4819, 0014-4819 KW - Tetraethylammonium Compounds KW - 0 KW - Tetrodotoxin KW - 4368-28-9 KW - 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester KW - 71145-03-4 KW - Nitrendipine KW - 9B627AW319 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Nitrendipine -- pharmacology KW - Animals KW - Cells, Cultured KW - Tetraethylammonium Compounds -- pharmacology KW - Mice KW - Membrane Potentials -- drug effects KW - Action Potentials -- drug effects KW - Tetrodotoxin -- pharmacology KW - Electric Stimulation KW - Ganglia, Spinal -- cytology KW - Ganglia, Spinal -- physiology KW - Synaptic Transmission -- drug effects KW - Calcium -- physiology KW - 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester -- pharmacology KW - Ganglia, Spinal -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78403207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+brain+research&rft.atitle=Calcium+agonist+%28BayK+8644%29+augments+voltage-sensitive+calcium+currents+but+not+synaptic+transmission+in+cultured+mouse+spinal+cord+neurons.&rft.au=Yu%2C+C%3BJia%2C+M%3BLitzinger%2C+M%3BNelson%2C+P+G&rft.aulast=Yu&rft.aufirst=C&rft.date=1988-01-01&rft.volume=71&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Experimental+brain+research&rft.issn=00144819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-27 N1 - Date created - 1988-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fenfluramine-induced suppression of food intake and locomotor activity is differentially altered by the selective type A monoamine oxidase inhibitor clorgyline. AN - 78401817; 3137616 AB - Administration of fenfluramine to rats produced decreases in 1-h food intake and locomotor activity. Short-term (2-6 days) or long-term (21-25 days) treatment with the monoamine oxidase (MAO) type A inhibiting antidepressant clorgyline potentiated fenfluramine-induced suppression of food intake but did not affect fenfluramine-induced suppression of locomotor activity. Although daily (4 h) food intake was not significantly less in clorgyline-treated animals relative to saline-treated controls, body weight gain was significantly less in clorgyline-treated animals relative to controls. These findings demonstrate a differential effect of clorgyline treatment on fenfluramine-induced suppression of food intake and locomotor activity. JF - Psychopharmacology AU - Aulakh, C S AU - Hill, J L AU - Wozniak, K M AU - Murphy, D L AD - Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 313 EP - 317 VL - 95 IS - 3 SN - 0033-3158, 0033-3158 KW - Propylamines KW - 0 KW - Fenfluramine KW - 2DS058H2CF KW - Clorgyline KW - LYJ16FZU9Q KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Drug Interactions KW - Body Weight -- drug effects KW - Time Factors KW - Male KW - Eating -- drug effects KW - Propylamines -- pharmacology KW - Motor Activity -- drug effects KW - Clorgyline -- pharmacology KW - Fenfluramine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78401817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Fenfluramine-induced+suppression+of+food+intake+and+locomotor+activity+is+differentially+altered+by+the+selective+type+A+monoamine+oxidase+inhibitor+clorgyline.&rft.au=Aulakh%2C+C+S%3BHill%2C+J+L%3BWozniak%2C+K+M%3BMurphy%2C+D+L&rft.aulast=Aulakh&rft.aufirst=C&rft.date=1988-01-01&rft.volume=95&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-11 N1 - Date created - 1988-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Estramustine phosphate (estracyt) following androgens in men with refractory stage D2 prostate cancer. AN - 78396767; 3409448 AB - Twenty-two orchiectomized men with progressive stage D2 prostate cancer were treated with a 3-week cycle of estramustine phosphate (EMP: from day 3 to day 21) and androgen priming (from day 1 to day 4). A partial response according to the NPCP-USA criteria was shown in 4 of 20 evaluable patients. Median progression-free survival of all patients was 24 weeks (range, 4-48) and median survival, 42 weeks (range, 4-112). Although in two cases treatment had to be stopped due to a marked increase in bone pain, no life-threatening side effects were observed. The androgen sensitivity of tumors was supported by the occurrence of increase in prostatic phosphatase and in bone pain in most patients. In this group of patients, androgen priming did not seem to potentiate the effectiveness of EMP, our results being comparable to those previously reported using EMP alone. JF - Cancer chemotherapy and pharmacology AU - Boccardo, F AU - Decensi, A AU - Guarneri, D AU - Martorana, G AU - Giberti, C AU - Giuliani, L AD - Department of Clinical Oncology, National Cancer Institute, Genova, Italy. Y1 - 1988 PY - 1988 DA - 1988 SP - 172 EP - 174 VL - 22 IS - 2 SN - 0344-5704, 0344-5704 KW - Nitrogen Mustard Compounds KW - 0 KW - Estramustine KW - 35LT29625A KW - Fluoxymesterone KW - 9JU12S4YFY KW - Index Medicus KW - Drug Interactions KW - Neoplasm Staging KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Orchiectomy KW - Prostatic Neoplasms -- pathology KW - Nitrogen Mustard Compounds -- therapeutic use KW - Prostatic Neoplasms -- drug therapy KW - Fluoxymesterone -- therapeutic use KW - Estramustine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78396767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Estramustine+phosphate+%28estracyt%29+following+androgens+in+men+with+refractory+stage+D2+prostate+cancer.&rft.au=Boccardo%2C+F%3BDecensi%2C+A%3BGuarneri%2C+D%3BMartorana%2C+G%3BGiberti%2C+C%3BGiuliani%2C+L&rft.aulast=Boccardo&rft.aufirst=F&rft.date=1988-01-01&rft.volume=22&rft.issue=2&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-29 N1 - Date created - 1988-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modulation of induced resistance to adriamycin in two human breast cancer cell lines with tamoxifen or perhexiline maleate. AN - 78396716; 3409446 AB - The clinical utility of adriamycin in the treatment of patients with metastatic breast cancer is often-limited by the development of drug resistance. It has been recognized that in addition to the development of primary resistance against adriamycin, malignant cells can simultaneously develop cross-resistance to other agents. An adriamycin-resistant human breast cancer cell line (MCF 7Ad) was developed by exposing the parent line (MCF 7) to gradually increasing concentrations of adriamycin while the cells were being grown in monolayer. Using these lines in a clonogenic assay, the relative drug sensitivities to adriamycin, vinblastine, melphalan, 5-fluorouracil and methotrexate were studied. MCF 7Ad was 12.5-fold more resistant to adriamycin than MCF 7 and 500-fold cross-resistant to vinblastine. There was no cross-resistance to melphalan, 5-fluorouracil or methotrexate. The resistance of MCF 7Ad was decreased by simultaneous exposure to tamoxifen (by a factor of 3.33) or perhexiline maleate (by a factor of 7.50). This decreased resistance was evidenced by a shift to the left of the sensitivity curves. However, there was no consistent change in the sensitivity curves of MCF 7. At the selected concentration of tamoxifen and perhexiline maleate, the cloning efficiency of MCF 7 and MCF 7Ad was 80%-90% of control values in medium without tamoxifen, perhexiline maleate or cytotoxic drugs. The resistance of MCF 7Ad to adriamycin was associated with a lower accumulation of [14C]adriamycin than exhibited by the sensitive MCF 7 line. There was no consistent change in [14C]adriamycin accumulation in MCF 7 or MCF 7Ad when tamoxifen was added, but when perhexiline maleate was added the [14C] accumulation increased. These results suggest that the tamoxifen-induced change in MCF 7Ad adriamycin resistance was not due to an increase in the amount of cell-associated adriamycin, but rather to some other mechanism that increased the cytotoxicity of the adriamycin. JF - Cancer chemotherapy and pharmacology AU - Foster, B J AU - Grotzinger, K R AU - McKoy, W M AU - Rubinstein, L V AU - Hamilton, T C AD - Investigational Drug Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 147 EP - 152 VL - 22 IS - 2 SN - 0344-5704, 0344-5704 KW - Tamoxifen KW - 094ZI81Y45 KW - Vinblastine KW - 5V9KLZ54CY KW - Doxorubicin KW - 80168379AG KW - perhexiline maleate KW - K7V8Y90G0H KW - Perhexiline KW - KU65374X44 KW - Melphalan KW - Q41OR9510P KW - Fluorouracil KW - U3P01618RT KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Vinblastine -- therapeutic use KW - Fluorouracil -- therapeutic use KW - Drug Interactions KW - Humans KW - Cell Line -- drug effects KW - Methotrexate -- therapeutic use KW - Drug Resistance KW - Melphalan -- therapeutic use KW - Tumor Stem Cell Assay KW - Breast Neoplasms -- drug therapy KW - Tamoxifen -- pharmacology KW - Doxorubicin -- pharmacokinetics KW - Perhexiline -- pharmacology KW - Perhexiline -- analogs & derivatives KW - Doxorubicin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78396716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Modulation+of+induced+resistance+to+adriamycin+in+two+human+breast+cancer+cell+lines+with+tamoxifen+or+perhexiline+maleate.&rft.au=Foster%2C+B+J%3BGrotzinger%2C+K+R%3BMcKoy%2C+W+M%3BRubinstein%2C+L+V%3BHamilton%2C+T+C&rft.aulast=Foster&rft.aufirst=B&rft.date=1988-01-01&rft.volume=22&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-29 N1 - Date created - 1988-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Drug solubilizers to aid pharmacologists: amorphous cyclodextrin derivatives. AN - 78370445; 2841549 AB - Conversion of crystalline alpha-, beta-, or gamma-cyclodextrins into amorphous mixtures of water soluble derivatives yields non-toxic solubilizers which dissolve drugs through the formation of inclusion complexes. From these types of compounds 2-hydroxypropyl ethers of cyclodextrins have presently been investigated and the ranges for the safe use in working with (a) receptor binding assays on membrane preparations, (b) cells in vitro, and (c) parenteral use in mice were established for these compounds. The drugs which were investigated were dissolved in amounts linearly proportionate to the concentration of the solubilizers used and did not precipitate upon dilution by aqueous media. These solubilizers may considerably facilitate pharmacological evaluation of new, water insoluble potential drugs. JF - Life sciences AU - Pitha, J AU - Irie, T AU - Sklar, P B AU - Nye, J S AD - National Institute on Aging/GRC, Baltimore, MD 21224. Y1 - 1988 PY - 1988 DA - 1988 SP - 493 EP - 502 VL - 43 IS - 6 SN - 0024-3205, 0024-3205 KW - Cyclodextrins KW - 0 KW - Dextrins KW - Receptors, Adrenergic, beta KW - Starch KW - 9005-25-8 KW - Pindolol KW - BJ4HF6IU1D KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Index Medicus KW - Rats KW - Receptors, Adrenergic, beta -- metabolism KW - Pindolol -- metabolism KW - Fibroblasts -- drug effects KW - Animals KW - Olfactory Mucosa -- enzymology KW - Solubility KW - Chemistry, Pharmaceutical KW - Humans KW - Anura KW - Adenylyl Cyclases -- metabolism KW - Receptors, Adrenergic, beta -- drug effects KW - Mice KW - Dextrins -- pharmacology KW - Cyclodextrins -- pharmacology KW - Starch -- pharmacology KW - Starch -- toxicity KW - Cyclodextrins -- toxicity KW - Dextrins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78370445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Drug+solubilizers+to+aid+pharmacologists%3A+amorphous+cyclodextrin+derivatives.&rft.au=Pitha%2C+J%3BIrie%2C+T%3BSklar%2C+P+B%3BNye%2C+J+S&rft.aulast=Pitha&rft.aufirst=J&rft.date=1988-01-01&rft.volume=43&rft.issue=6&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-12 N1 - Date created - 1988-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Needle sharing among intravenous drug abusers: an overview. AN - 78362686; 3136335 JF - NIDA research monograph AU - Battjes, R J AU - Pickens, R W AD - Division of Clinical Research, National Institute on Drug Abuse, Rockville, MD 20857. Y1 - 1988 PY - 1988 DA - 1988 SP - 1 EP - 6 VL - 80 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - AIDS/HIV KW - Injections, Intravenous KW - Humans KW - Needles KW - Acquired Immunodeficiency Syndrome -- transmission KW - Substance-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78362686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Needle+sharing+among+intravenous+drug+abusers%3A+an+overview.&rft.au=Battjes%2C+R+J%3BPickens%2C+R+W&rft.aulast=Battjes&rft.aufirst=R&rft.date=1988-01-01&rft.volume=80&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-15 N1 - Date created - 1988-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biological evaluation of compounds for their physical dependence potential and abuse liability. XI. Drug testing program of the Committee on Problems of Drug Dependence, Inc. (1987). AN - 78354224; 2900468 JF - NIDA research monograph AU - Jacobson, A AD - Drug Design and Synthesis Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 466 EP - 484 VL - 81 SN - 1046-9516, 1046-9516 KW - Analgesics KW - 0 KW - Central Nervous System Depressants KW - Central Nervous System Stimulants KW - Index Medicus KW - Animals KW - Central Nervous System Depressants -- adverse effects KW - Humans KW - Central Nervous System Stimulants -- adverse effects KW - Analgesics -- adverse effects KW - Research Design -- methods KW - Substance-Related Disorders -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78354224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Biological+evaluation+of+compounds+for+their+physical+dependence+potential+and+abuse+liability.+XI.+Drug+testing+program+of+the+Committee+on+Problems+of+Drug+Dependence%2C+Inc.+%281987%29.&rft.au=Jacobson%2C+A&rft.aulast=Jacobson&rft.aufirst=A&rft.date=1988-01-01&rft.volume=81&rft.issue=&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-15 N1 - Date created - 1988-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Initiatives at the National Institute on Drug Abuse. AN - 78353276; 3136350 JF - NIDA research monograph AU - Schuster, C AD - National Institute on Drug Abuse, Rockville, MD. Y1 - 1988 PY - 1988 DA - 1988 SP - 1 EP - 5 VL - 81 SN - 1046-9516, 1046-9516 KW - Nitrosamines KW - 0 KW - N-nitrosoiminodiacetic acid KW - 25081-31-6 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - United States KW - Humans KW - Adult KW - Substance-Related Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78353276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Initiatives+at+the+National+Institute+on+Drug+Abuse.&rft.au=Schuster%2C+C&rft.aulast=Schuster&rft.aufirst=C&rft.date=1988-01-01&rft.volume=81&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-15 N1 - Date created - 1988-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - HIV infection among intravenous drug abusers in the United States and Europe. AN - 78352329; 3136347 AB - AIDS is a serious public health problem for IVDAs in the United States and Europe. Although AIDS and HIV infection are concentrated in New York and New Jersey in the United States, and in Italy and Spain in Europe, AIDS has been diagnosed and reported among IVDAs in all 50 States of the United States and 16 countries in Europe. It is quite apparent that, once HIV is introduced into a group of IVDAs, it can spread readily between IVDAs, to their sexual partners, and to their children in utero. Unfortunately, one can only expect HIV seroprevalence rates and AIDS cases to continue to increase among IVDAs worldwide for at least the next several years. Concerted efforts to develop, implement, and evaluate potential prevention strategies among IVDAs are urgently needed. JF - NIDA research monograph AU - Haverkos, H W AD - Division of Clinical Research, National Institute on Drug Abuse, Rockville, MD 20857. Y1 - 1988 PY - 1988 DA - 1988 SP - 7 EP - 17 VL - 80 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - AIDS/HIV KW - United States KW - Injections, Intravenous KW - Humans KW - Europe KW - Needles KW - Acquired Immunodeficiency Syndrome -- transmission KW - Substance-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78352329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=HIV+infection+among+intravenous+drug+abusers+in+the+United+States+and+Europe.&rft.au=Haverkos%2C+H+W&rft.aulast=Haverkos&rft.aufirst=H&rft.date=1988-01-01&rft.volume=80&rft.issue=&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-15 N1 - Date created - 1988-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Signals controlling alternative splicing of major histocompatibility complex H-2 class I pre-mRNA. AN - 78340248; 3397132 AB - The use of alternative splice acceptor sites during the removal of intron 7 in pre-mRNA splicing produces two forms of H-2Kb protein: the predominant form, derived from a transcript that has spliced at the upstream splice acceptor site for exon 8 (long exon 8), and a Kb molecule derived from a transcript that has spliced at the downstream acceptor site for exon 8 (short exon 8). We have identified a potential lariat branch point adenosine for the upstream acceptor splice site. This adenosine is found 28 bp from the splice junction and is contained in the sequence AGTGATGG. D-region genes, which use only the downstream splice site, have the sequence AGTGGTGG. We have used in vitro mutagenesis to change this A of the H-2Kb gene to G and have made the reciprocal change in H-2Dd. Elimination of this adenosine in H-2Kb alters the pattern of pre-mRNA splicing and results in a predominance of the Kb molecules with short exon 8 encoded sequences. However, the addition of an adenosine in H-2Dd is not sufficient to direct splicing to the upstream site. JF - Immunogenetics AU - Handy, D E AU - McCluskey, J AU - Lew, A M AU - Coligan, J E AU - Margulies, D H AD - Biological Resources Branch, National Institutes of Health, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 81 EP - 90 VL - 28 IS - 2 SN - 0093-7711, 0093-7711 KW - H-2 Antigens KW - 0 KW - Nucleic Acid Precursors KW - RNA, Messenger KW - Index Medicus KW - L Cells (Cell Line) KW - Animals KW - Base Sequence KW - Cell Membrane -- immunology KW - Transfection KW - DNA Mutational Analysis KW - Introns KW - Mice KW - Gene Expression Regulation KW - Nucleic Acid Precursors -- genetics KW - Genes, MHC Class I KW - H-2 Antigens -- genetics KW - RNA Splicing KW - RNA, Messenger -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78340248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Association+for+Vascular+Access&rft.atitle=Defining+the+Specialty+of+Vascular+Access+through+Consensus%3A+Shaping+the+Future+of+Vascular+Access&rft.au=Davis%2C+Lois%3BOwens%2C+Andrea+K%3BThompson%2C+Judy&rft.aulast=Davis&rft.aufirst=Lois&rft.date=2016-09-01&rft.volume=21&rft.issue=3&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Association+for+Vascular+Access&rft.issn=15528855&rft_id=info:doi/10.1016%2Fj.java.2016.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-07 N1 - Date created - 1988-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increased metallothionein gene expression in 5-aza-2'-deoxycytidine-induced resistance to cadmium cytotoxicity. AN - 78339854; 2456160 AB - The pyrimidine analog, 5-azacytidine (AZA-CR), has been shown to increase the expression of the metallothionein (MT) gene and to induce tolerance to cadmium toxicity. Since incorporation into DNA of AZA-CR appears to be required for this effect, the deoxynucleoside of AZA-CR should also be effective. Therefore, this study was undertaken to assess the effect of 5-aza-2'-deoxycytidine (AZA-CdR) pretreatment on cadmium-induced cytotoxicity and MT expression in cultured cells. TRL 1215 cells in log phase of growth were exposed to AZA-CdR (0.4, 0.8, 4.0, 8.0 microM) followed 48 h later by the addition of cadmium (10 microM). MT concentrations were measured 24 h after the addition of cadmium. AZA-CdR alone caused modest, dose-related increases in MT levels (2.3-fold maximum), while cadmium alone resulted in a 9.5-fold increase. Pretreatment with AZA-CdR in combination with cadmium caused a 19--24-fold increase in cellular MT at all doses of AZA-CdR. Addition of the DNA synthesis inhibitor, hydroxyurea (HU), to the incubation medium during AZA-CdR exposure prevented the enhancing effect of the analog on cadmium induction of MT accumulation. Time course studies revealed that AZA-CdR pretreatment reduced the time required for cadmium to induce MT levels from 4--8 h to 0--2 h. AZA-CdR pretreated cells placed in suspension with cadmium (125 microM) showed a marked reduction in cadmium-induced cytotoxicity as reflected by reduced glutamic-oxaloacetic transaminase (GOT) loss. Uptake studies showed that AZA-CdR pretreatment had no effect on cadmium transport during the initial phases of exposure, indicating that an alteration in the toxicokinetics of the metal did not account for the reduction in toxicity. AZA-CdR did, however, cause hypomethylation of the MT-I gene. These results suggest that AZA-CdR pretreatment induces tolerance to cadmium toxicity by increasing the genetic expression of MT possibly through hypomethylation of the MT gene. JF - Chemico-biological interactions AU - Waalkes, M P AU - Miller, M S AU - Wilson, M J AU - Bare, R M AU - McDowell, A E AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, MD 21701-1013. Y1 - 1988 PY - 1988 DA - 1988 SP - 189 EP - 204 VL - 66 IS - 3-4 SN - 0009-2797, 0009-2797 KW - Cadmium KW - 00BH33GNGH KW - decitabine KW - 776B62CQ27 KW - DNA KW - 9007-49-2 KW - Metallothionein KW - 9038-94-2 KW - DNA Restriction Enzymes KW - EC 3.1.21.- KW - Azacitidine KW - M801H13NRU KW - Hydroxyurea KW - X6Q56QN5QC KW - Index Medicus KW - Animals KW - Azacitidine -- pharmacology KW - Dose-Response Relationship, Drug KW - Azacitidine -- analogs & derivatives KW - Drug Resistance KW - Nucleic Acid Hybridization KW - Rats KW - Rats, Inbred F344 KW - Cell Survival -- drug effects KW - Kinetics KW - DNA -- genetics KW - Methylation KW - Cell Line KW - Liver -- drug effects KW - Cadmium -- toxicity KW - Metallothionein -- genetics KW - Liver -- metabolism KW - Gene Expression Regulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78339854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Increased+metallothionein+gene+expression+in+5-aza-2%27-deoxycytidine-induced+resistance+to+cadmium+cytotoxicity.&rft.au=Waalkes%2C+M+P%3BMiller%2C+M+S%3BWilson%2C+M+J%3BBare%2C+R+M%3BMcDowell%2C+A+E&rft.aulast=Waalkes&rft.aufirst=M&rft.date=1988-01-01&rft.volume=66&rft.issue=3-4&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-02 N1 - Date created - 1988-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of the effects of carbon tetrachloride and of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the disposition of linoleic acid in rat liver in vitro. AN - 78336882; 3135123 AB - Both 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and carbon tetrachloride (CCl4) have conspicuous effects on lipid metabolism in rat liver. Although it is generally accepted that CCl4 administration leads to hepatic lipid peroxidation in vivo, conflicting reports from different laboratories make it unclear whether or not lipid peroxidation is involved in the mechanism of toxicity of TCDD. The present study involved pretreating F344 rats with CCl4 or TCDD, then at predetermined times thereafter, giving [U-14C]linoleic acid. A variety of compound classes were monitored in extracts of liver taken 30 min after the label was given. A previously unreported effect of CCl4 was a conspicuous increase in turnover of 1,2-diglycerides. That CCl4 did cause lipid peroxidation was evident from the presence of allylic hydroxyacids not seen in vehicle-treated controls, greatly increased radioactivity in protein-bound material, and decreased levels of arachidonate without decreased synthesis from linolate. Where effects of TCDD pretreatment could be seen, they were much less than the corresponding effects of CCl4. No allylic hydroxyacids were detected in livers of TCDD-treated rats. The concentration of arachidonate was not reduced, and elongation of linolate was not stimulated, indicating that TCDD did not cause extensive-but-repaired peroxidation. It is concluded that while TCDD may slightly increase hepatic lipid peroxidation in rats in vivo, the extent of such stimulation appears to be too slight to account for the toxicity of TCDD. JF - Chemico-biological interactions AU - Albro, P W AU - Corbett, J T AU - Schroeder, J L AU - Harvan, D AD - Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 267 EP - 285 VL - 66 IS - 3-4 SN - 0009-2797, 0009-2797 KW - Aldehydes KW - 0 KW - Arachidonic Acids KW - Carbon Radioisotopes KW - Dioxins KW - Fatty Acids KW - Linoleic Acids KW - Lipid Peroxides KW - Polychlorinated Dibenzodioxins KW - Arachidonic Acid KW - 27YG812J1I KW - Linoleic Acid KW - 9KJL21T0QJ KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - 4-hydroxy-2-nonenal KW - K1CVM13F96 KW - Index Medicus KW - Animals KW - Arachidonic Acids -- metabolism KW - Fatty Acids -- metabolism KW - Rats KW - Oxidation-Reduction KW - Rats, Inbred F344 KW - Kinetics KW - Aldehydes -- metabolism KW - Gas Chromatography-Mass Spectrometry KW - Chromatography, Thin Layer KW - Lipid Peroxides -- metabolism KW - Female KW - Carbon Tetrachloride -- pharmacology KW - Liver -- drug effects KW - Polychlorinated Dibenzodioxins -- pharmacology KW - Linoleic Acids -- metabolism KW - Liver -- metabolism KW - Dioxins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78336882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Comparison+of+the+effects+of+carbon+tetrachloride+and+of+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin+on+the+disposition+of+linoleic+acid+in+rat+liver+in+vitro.&rft.au=Albro%2C+P+W%3BCorbett%2C+J+T%3BSchroeder%2C+J+L%3BHarvan%2C+D&rft.aulast=Albro&rft.aufirst=P&rft.date=1988-01-01&rft.volume=21&rft.issue=3&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Association+for+Vascular+Access&rft.issn=15528855&rft_id=info:doi/10.1016%2Fj.java.2016.06.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-02 N1 - Date created - 1988-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ex vivo activation of killer monocytes (AKM) and their application to the treatment of human cancer. AN - 78336451; 3135291 AB - Human blood monocytes activated by gamma interferon have been shown to be highly tumoricidal against colon cancer cells in vitro. Monocytes from patients with peritoneal colorectal carcinomatosis (PCC) were purified by a combination of cytapheresis and elutriation procedures, followed by in vitro incubation with gamma interferon for 18 hours. After debulking surgery, activated killer monocytes (AKM) were reinfused into patients' peritoneal cavities weekly for 16 weeks. To date, six patients have completed the entire protocol and three have completed maintenance therapy. All have tolerated the therapy well with acceptable toxicity. Midway through the protocol, we analyzed the trafficking pattern of the AKM by prelabeling them with 111In. Distribution was relatively homogeneous throughout the peritoneum; at the second staging celiotomy, three of the seven PCC patients were found to have very small amounts of recurrent disease in places to which the AKM were felt to have had limited access (other areas remained disease-free); these areas of recurrent disease were surgically resectable. AKM have also been infused systemically into five cancer patients. First, the patients were infused with unactivated 111In-labeled monocytes; 1 month later each patient received 111In-labeled gamma interferon-activated AKM. Trafficking studies indicated that both forms of monocytes migrated to sites in the reticuloendothelial system. We have seen virtually no complications from intravenous infusions of either unactivated or gamma interferon-activated AKM.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of clinical apheresis AU - Stevenson, H C AU - Lacerna, L V AU - Sugarbaker, P H AD - Biological Response Modifiers Program, NCI-Frederick Cancer Research Facility, MD 21701. Y1 - 1988 PY - 1988 DA - 1988 SP - 118 EP - 121 VL - 4 IS - 2-3 SN - 0733-2459, 0733-2459 KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - Humans KW - Adult KW - Clinical Trials as Topic KW - Monocytes -- drug effects KW - Interferon-gamma -- pharmacology KW - Middle Aged KW - Male KW - Female KW - Lymphocyte Activation KW - Peritoneal Neoplasms -- secondary KW - Immunization, Passive KW - Leukocytes, Mononuclear -- immunology KW - Leukocytes, Mononuclear -- drug effects KW - Peritoneal Neoplasms -- therapy KW - Killer Cells, Natural -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78336451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+apheresis&rft.atitle=Ex+vivo+activation+of+killer+monocytes+%28AKM%29+and+their+application+to+the+treatment+of+human+cancer.&rft.au=Stevenson%2C+H+C%3BLacerna%2C+L+V%3BSugarbaker%2C+P+H&rft.aulast=Stevenson&rft.aufirst=H&rft.date=1988-01-01&rft.volume=4&rft.issue=2-3&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+apheresis&rft.issn=07332459&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-02 N1 - Date created - 1988-09-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Clin Apheresis 1989;5(1):59 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Seizure-induced alterations in the metabolism of hippocampal opioid peptides suggest opioid modulation of seizure-related behaviors. AN - 78335094; 2899842 AB - The evidence accumulated so far indicates that seizure activity exerts profound changes on the metabolism of opioid peptides in the hippocampus. Our data consistently show a large transient decrease in dynorphin and a modest decrease in enkephalin in the hippocampus following either a single ECS or KA injection. These initial reductions, which are indicative of increased release, may trigger the biosynthetic process of hippocampal opioids and result in an overproduction of the peptides seen in the rebound phase. However, the amount and timing of the rebound in enkephalin and dynorphin levels in response to repeated ECS, amygdaloid kindling, or KA differ drastically: a rapid and sustained increase in ME-LI follows all three treatments, in contrast to a slow recovery after a large and sustained decrease in DN-LI induced by repeated ECS and amygdaloid kindling. These results, which are unique to the hippocampus, suggest that differential mechanisms are operative in regulating the metabolism of these two opioid peptides in the hippocampus. It is likely that a well-coordinated regulation of hippocampal function can be achieved through the differential release of enkephalin and dynorphin and their subsequent interactions at different subtypes of opioid receptors following seizure activities. From a functional point of view, our data provide a neurochemical correlate of previous reports that brain opioid peptides may mediate ECS-induced behavioral alterations, such as changes in seizure threshold, postictal depression, and retrograde amnesia. The robust changes in the levels of opioid peptides in kindled rats, plus shortening of the kindling process by pretreatment with mu opioid antagonists, strongly suggest the involvement of brain opioid peptides in the development of kindling. Finally, these studies show clear evidence that enkephalin in the hippocampus is important in KA-induced WDS, a component of the opiate withdrawal syndrome in rodents (Isaacson and Lanthorn 1981). Further studies should help distinguish the regulatory mechanisms responsible for changes in opioid peptide metabolism during states of hyperexcitability in the hippocampal formation. JF - NIDA research monograph AU - Hong, J S AU - McGinty, J F AU - Grimes, L AU - Kanamatsu, T AU - Obie, J AU - Mitchell, C L AD - Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 48 EP - 66 VL - 82 SN - 1046-9516, 1046-9516 KW - Endorphins KW - 0 KW - Enkephalin, Methionine KW - 58569-55-4 KW - Dynorphins KW - 74913-18-1 KW - Kainic Acid KW - SIV03811UC KW - Colchicine KW - SML2Y3J35T KW - Index Medicus KW - Animals KW - Amygdala -- metabolism KW - Kindling, Neurologic KW - Enkephalin, Methionine -- metabolism KW - Electroshock KW - Dynorphins -- metabolism KW - Seizures -- chemically induced KW - Endorphins -- metabolism KW - Hippocampus -- metabolism KW - Seizures -- metabolism KW - Behavior, Animal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78335094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Seizure-induced+alterations+in+the+metabolism+of+hippocampal+opioid+peptides+suggest+opioid+modulation+of+seizure-related+behaviors.&rft.au=Hong%2C+J+S%3BMcGinty%2C+J+F%3BGrimes%2C+L%3BKanamatsu%2C+T%3BObie%2C+J%3BMitchell%2C+C+L&rft.aulast=Hong&rft.aufirst=J&rft.date=1988-01-01&rft.volume=82&rft.issue=&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-02 N1 - Date created - 1988-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human myeloperoxidase and thyroid peroxidase, two enzymes with separate and distinct physiological functions, are evolutionarily related members of the same gene family. AN - 78333508; 2840655 AB - Human myeloperoxidase and human thyroid peroxidase nucleotide and amino acid sequences were compared. The global similarities of the nucleotide and amino acid sequences are 46% and 44%, respectively. These similarities are most evident within the coding sequence, especially that encoding the myeloperoxidase functional subunits. These results clearly indicate that myeloperoxidase and thyroid peroxidase are members of the same gene family and diverged from a common ancestral gene. The residues at 416 in myeloperoxidase and 407 in thyroid peroxidase were estimated as possible candidates for the proximal histidine residues that link to the iron centers of the enzymes. The primary structures around these histidine residues were compared with those of other known peroxidases. The similarity in this region between the two animal peroxidases (amino acid 396-418 in thyroid peroxidase and 405-427 in myeloperoxidase) is 74%; however, those between the animal peroxidases and other yeast and plant peroxidases are not significantly high, although several conserved features have been observed. The possible location of the distal histidine residues in myeloperoxidase and thyroid peroxidase amino acid sequences are also discussed. JF - Proteins AU - Kimura, S AU - Ikeda-Saito, M AD - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 113 EP - 120 VL - 3 IS - 2 SN - 0887-3585, 0887-3585 KW - Peroxidase KW - EC 1.11.1.7 KW - Iodide Peroxidase KW - EC 1.11.1.8 KW - Index Medicus KW - Base Sequence KW - Sequence Homology, Nucleic Acid KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Genes KW - Peroxidase -- genetics KW - Biological Evolution KW - Iodide Peroxidase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78333508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins&rft.atitle=Human+myeloperoxidase+and+thyroid+peroxidase%2C+two+enzymes+with+separate+and+distinct+physiological+functions%2C+are+evolutionarily+related+members+of+the+same+gene+family.&rft.au=Kimura%2C+S%3BIkeda-Saito%2C+M&rft.aulast=Kimura&rft.aufirst=S&rft.date=1988-01-01&rft.volume=3&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Proteins&rft.issn=08873585&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-26 N1 - Date created - 1988-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Kaposi's sarcoma and nitrite inhalants. AN - 78332187; 2899948 JF - Advances in biochemical psychopharmacology AU - Haverkos, H W AD - Clinical Medicine Branch, National Institute on Drug Abuse, Alcohol, Drug Abuse, Rockville, Maryland 20857. Y1 - 1988 PY - 1988 DA - 1988 SP - 165 EP - 172 VL - 44 SN - 0065-2229, 0065-2229 KW - Amyl Nitrite KW - 8017-89-8 KW - Index Medicus KW - AIDS/HIV KW - Risk Factors KW - Humans KW - Homosexuality KW - Administration, Inhalation KW - Male KW - Acquired Immunodeficiency Syndrome -- complications KW - Amyl Nitrite -- adverse effects KW - Sarcoma, Kaposi -- chemically induced KW - Skin Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78332187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+biochemical+psychopharmacology&rft.atitle=Kaposi%27s+sarcoma+and+nitrite+inhalants.&rft.au=Haverkos%2C+H+W&rft.aulast=Haverkos&rft.aufirst=H&rft.date=1988-01-01&rft.volume=19&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Association+for+Vascular+Access&rft.issn=15528855&rft_id=info:doi/10.1016%2Fj.java.2013.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-08 N1 - Date created - 1988-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - raf protooncogene expression in neural and immune tissues. AN - 78328285; 3041752 JF - Advances in biochemical psychopharmacology AU - Mark, G E AU - Pfeifer, A AU - Mann, D L AU - Harris, C C AU - Berman, R AU - Pert, C B AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 45 EP - 55 VL - 44 SN - 0065-2229, 0065-2229 KW - Proto-Oncogene Proteins KW - 0 KW - Proto-Oncogene Proteins c-raf KW - EC 2.7.11.1 KW - Index Medicus KW - Animals KW - Brain Neoplasms -- genetics KW - Humans KW - B-Lymphocytes -- immunology KW - T-Lymphocytes -- immunology KW - Cloning, Molecular KW - Gene Expression Regulation KW - Proto-Oncogenes KW - Proto-Oncogene Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78328285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+biochemical+psychopharmacology&rft.atitle=raf+protooncogene+expression+in+neural+and+immune+tissues.&rft.au=Mark%2C+G+E%3BPfeifer%2C+A%3BMann%2C+D+L%3BHarris%2C+C+C%3BBerman%2C+R%3BPert%2C+C+B&rft.aulast=Mark&rft.aufirst=G&rft.date=1988-01-01&rft.volume=44&rft.issue=&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Advances+in+biochemical+psychopharmacology&rft.issn=00652229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-08 N1 - Date created - 1988-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhalation toxicity and carcinogenesis studies of methylene chloride (dichloromethane) in F344/N rats and B6C3F1 mice. AN - 78300992; 3389664 JF - Annals of the New York Academy of Sciences AU - Mennear, J H AU - McConnell, E E AU - Huff, J E AU - Renne, R A AU - Giddens, E AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 343 EP - 351 VL - 534 SN - 0077-8923, 0077-8923 KW - Hydrocarbons, Chlorinated KW - 0 KW - Methylene Chloride KW - 588X2YUY0A KW - Index Medicus KW - Rats KW - Mammary Neoplasms, Experimental -- chemically induced KW - Animals KW - Rats, Inbred F344 KW - Mice KW - Administration, Inhalation KW - Male KW - Female KW - Hydrocarbons, Chlorinated -- toxicity KW - Methylene Chloride -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78300992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Inhalation+toxicity+and+carcinogenesis+studies+of+methylene+chloride+%28dichloromethane%29+in+F344%2FN+rats+and+B6C3F1+mice.&rft.au=Mennear%2C+J+H%3BMcConnell%2C+E+E%3BHuff%2C+J+E%3BRenne%2C+R+A%3BGiddens%2C+E&rft.aulast=Mennear&rft.aufirst=J&rft.date=1988-01-01&rft.volume=534&rft.issue=&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-04 N1 - Date created - 1988-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Laboratory animal toxicity and carcinogenesis testing. Underlying concepts, advantages and constraints. AN - 78300834; 3291727 JF - Annals of the New York Academy of Sciences AU - Rall, D P AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 78 EP - 83 VL - 534 SN - 0077-8923, 0077-8923 KW - Index Medicus KW - Animals KW - Mutagenicity Tests KW - Humans KW - Disease Models, Animal KW - Animals, Laboratory KW - Neoplasms, Experimental -- chemically induced KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78300834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Association+for+Vascular+Access&rft.atitle=Development+and+Testing+of+a+Short+Peripheral+Intravenous+Catheter+Insertion+Skills+Checklist&rft.au=Schuster%2C+Catherine%3BStahl%2C+Brian%3BMurray%2C+Connie%3BKeleekai%2C+Nowai+L%3BGlover%2C+Kevin&rft.aulast=Schuster&rft.aufirst=Catherine&rft.date=2016-12-01&rft.volume=21&rft.issue=4&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Association+for+Vascular+Access&rft.issn=15528855&rft_id=info:doi/10.1016%2Fj.java.2016.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-04 N1 - Date created - 1988-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic studies in rodents of vinyl acetate and compounds related to acrolein. AN - 78300709; 3389658 JF - Annals of the New York Academy of Sciences AU - Lijinsky, W AD - NCI-Frederick Cancer Research Facility, LBI-Basic Research Program, Maryland 21701. Y1 - 1988 PY - 1988 DA - 1988 SP - 246 EP - 254 VL - 534 SN - 0077-8923, 0077-8923 KW - Aldehydes KW - 0 KW - Propanols KW - Vinyl Compounds KW - allyl alcohol KW - 3W678R12M0 KW - Acrolein KW - 7864XYD3JJ KW - 1-Propanol KW - 96F264O9SV KW - vinyl acetate KW - L9MK238N77 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Biotransformation KW - 1-Propanol -- toxicity KW - Lethal Dose 50 KW - Vinyl Compounds -- toxicity KW - Acrolein -- analogs & derivatives KW - Acrolein -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78300709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nephron&rft.atitle=Renal+Association+Clinical+Practice+Guideline+on+Vascular+Access+for+Haemodialysis&rft.au=Fluck%2C+Richard%3BKumwenda%2C+Mick&rft.aulast=Fluck&rft.aufirst=Richard&rft.date=2011-05-01&rft.volume=118&rft.issue=&rft.spage=c225&rft.isbn=&rft.btitle=&rft.title=Nephron&rft.issn=00282766&rft_id=info:doi/10.1159%2F000328071 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-04 N1 - Date created - 1988-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Relationships between in vitro genetic toxicity and carcinogenicity studies in animals. AN - 78300661; 3291706 AB - In vitro genetic toxicity assays currently in use cannot be used to unambiguously define all potential carcinogens. The relationship between the various in vitro endpoints (mutation, cytogenetic effects, transformation) and the patterns of tumorigenicity is quite complex. Additional data, particularly for noncarcinogens, are needed to better understand the inconsistencies and to define the limits of predictability. For example, we must empirically define the concordance and discordance between in vivo and in vitro systems related to chemical classes or structures. At this time, since there are no nontrivial generalizations and no general predictivity is possible, we must use judgment in applying short-term test results. There is a clear need to identify as soon as possible the minimum number of in vitro systems that can be used, nonredundantly, to discriminate between carcinogens and noncarcinogens. However, we must continue to address the sources of discordance in order to understand the ways in which short-term test results can and cannot be used. Many trans-sex/trans-species carcinogens show the capacity to induce multiple endpoints of genetic toxicity and this class of rodent carcinogens may have the greatest implications for potential human health effects. A much more selective use of short-term test results to identify potential carcinogens such as these will achieve many of the goals for which these tests were developed. JF - Annals of the New York Academy of Sciences AU - Tennant, R W AD - Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 127 EP - 132 VL - 534 SN - 0077-8923, 0077-8923 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - In Vitro Techniques KW - Mutagenicity Tests -- methods KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78300661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Relationships+between+in+vitro+genetic+toxicity+and+carcinogenicity+studies+in+animals.&rft.au=Tennant%2C+R+W&rft.aulast=Tennant&rft.aufirst=R&rft.date=1988-01-01&rft.volume=534&rft.issue=&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-04 N1 - Date created - 1988-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic toxicity results and ongoing studies of 1,3-butadiene by the National Toxicology Program. AN - 78300610; 3291722 JF - Annals of the New York Academy of Sciences AU - Melnick, R L AU - Huff, J E AU - Haseman, J K AU - McConnell, E E AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 648 EP - 662 VL - 534 SN - 0077-8923, 0077-8923 KW - Butadienes KW - 0 KW - 1,3-butadiene KW - JSD5FGP5VD KW - Index Medicus KW - Animals KW - Hemangiosarcoma -- chemically induced KW - Mice KW - Rats, Inbred Strains KW - Body Weight KW - Rats KW - Heart Neoplasms -- chemically induced KW - Heart Neoplasms -- pathology KW - Hemangiosarcoma -- pathology KW - Follow-Up Studies KW - Administration, Inhalation KW - Time Factors KW - Female KW - Male KW - Butadienes -- toxicity KW - Butadienes -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78300610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Chronic+toxicity+results+and+ongoing+studies+of+1%2C3-butadiene+by+the+National+Toxicology+Program.&rft.au=Melnick%2C+R+L%3BHuff%2C+J+E%3BHaseman%2C+J+K%3BMcConnell%2C+E+E&rft.aulast=Melnick&rft.aufirst=R&rft.date=1988-01-01&rft.volume=534&rft.issue=&rft.spage=648&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-04 N1 - Date created - 1988-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Carcinogenesis studies: results of 398 experiments on 104 chemicals from the U.S. National Toxicology Program. AN - 78300484; 3291703 JF - Annals of the New York Academy of Sciences AU - Huff, J E AU - McConnell, E E AU - Haseman, J K AU - Boorman, G A AU - Eustis, S L AU - Schwetz, B A AU - Rao, G N AU - Jameson, C W AU - Hart, L G AU - Rall, D P AD - National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 1 EP - 30 VL - 534 SN - 0077-8923, 0077-8923 KW - Carcinogens KW - 0 KW - Index Medicus KW - United States KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Environmental Exposure KW - Toxicology KW - National Health Programs KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78300484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Carcinogenesis+studies%3A+results+of+398+experiments+on+104+chemicals+from+the+U.S.+National+Toxicology+Program.&rft.au=Huff%2C+J+E%3BMcConnell%2C+E+E%3BHaseman%2C+J+K%3BBoorman%2C+G+A%3BEustis%2C+S+L%3BSchwetz%2C+B+A%3BRao%2C+G+N%3BJameson%2C+C+W%3BHart%2C+L+G%3BRall%2C+D+P&rft.aulast=Huff&rft.aufirst=J&rft.date=1988-01-01&rft.volume=534&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-04 N1 - Date created - 1988-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Epidemiologic approaches to evaluation. Discussion paper. AN - 78300183; 3389668 JF - Annals of the New York Academy of Sciences AU - Rogan, W J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 394 VL - 534 SN - 0077-8923, 0077-8923 KW - Carcinogens KW - 0 KW - Index Medicus KW - Humans KW - Environmental Exposure KW - Epidemiologic Methods KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78300183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Epidemiologic+approaches+to+evaluation.+Discussion+paper.&rft.au=Rogan%2C+W+J&rft.aulast=Rogan&rft.aufirst=W&rft.date=1988-01-01&rft.volume=534&rft.issue=&rft.spage=394&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-04 N1 - Date created - 1988-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Carcinogenesis studies of benzene, methyl benzene, and dimethyl benzenes. AN - 78299850; 3389672 JF - Annals of the New York Academy of Sciences AU - Huff, J E AU - Eastin, W AU - Roycroft, J AU - Eustis, S L AU - Haseman, J K AD - National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 427 EP - 440 VL - 534 SN - 0077-8923, 0077-8923 KW - Xylenes KW - 0 KW - Toluene KW - 3FPU23BG52 KW - Benzene KW - J64922108F KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Male KW - Female KW - Xylenes -- toxicity KW - Benzene -- toxicity KW - Toluene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78299850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Carcinogenesis+studies+of+benzene%2C+methyl+benzene%2C+and+dimethyl+benzenes.&rft.au=Huff%2C+J+E%3BEastin%2C+W%3BRoycroft%2C+J%3BEustis%2C+S+L%3BHaseman%2C+J+K&rft.aulast=Huff&rft.aufirst=J&rft.date=1988-01-01&rft.volume=534&rft.issue=&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-04 N1 - Date created - 1988-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Viruses, oncogenes, and cancer. AN - 78298748; 3292041 AB - Our current theories of virus-induced cellular transformation have changed with the emerging recognition that all normal cells contain proto-oncogenes which convert to oncogenes and induce transformation when activated and/or amplified. Cellular oncogenes have been identified by homology to the transforming genes of acute retroviruses and by the transforming activity of tumor cell DNA in transfection assays. More than two dozen cellular oncogenes identified to date constitute a heterogeneous group of genes which are remarkably conserved among highly diverse species. Expression of proto-oncogenes is linked to normal growth and development; whereas their expression as oncogenes due to gene mutation, rearrangement, amplification or other processes leading to altered or overexpression is associated with the development of tumors. Functions of oncogene proteins are being identified. These include unique protein kinase activity, growth factor/growth factor receptor properties, and the presence of DNA-binding polypeptides. It also appears that cooperation between several activated cellular oncogenes may be required in the multistep process of oncogenesis. Our recent in vitro experimental evidence supports that human cell carcinogenesis is indeed a multistep process. In addition, the involvement of the activated cellular transforming genes met and H-ras in chemically induced human cell carcinogenesis has been shown. Advancement in molecular biology of oncogenes and their products is likely to result in improvements in cancer diagnosis and cancer therapy. JF - Cancer detection and prevention AU - Rhim, J S AD - Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 139 EP - 149 VL - 11 IS - 3-6 SN - 0361-090X, 0361-090X KW - Index Medicus KW - Humans KW - Gene Expression Regulation KW - Oncogenes KW - Retroviridae -- genetics KW - Neoplasms -- etiology KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78298748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+detection+and+prevention&rft.atitle=Viruses%2C+oncogenes%2C+and+cancer.&rft.au=Rhim%2C+J+S&rft.aulast=Rhim&rft.aufirst=J&rft.date=1988-01-01&rft.volume=11&rft.issue=3-6&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Cancer+detection+and+prevention&rft.issn=0361090X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-24 N1 - Date created - 1988-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lack of cardiovascular tolerance during intravenous cocaine infusions in human volunteers. AN - 78288894; 3386392 AB - Acute tolerance to the cardiovascular effects of cocaine has been hypothesized from experiments in which the plasma concentrations of cocaine were rapidly changing. We studied the cardiovascular responses of 8 male human subjects for 4 hours following intravenous bolus doses of cocaine, and compared these to responses in the same subjects after intravenous bolus doses of cocaine followed by continuous intravenous infusions of cocaine designed to maintain steady state plasma levels of cocaine. We found little evidence of tolerance to the tachycardia and hypertensive effects of cocaine during a four hour exposure. Lack of tolerance to the cardiovascular effects of cocaine may be a factor in some types of cocaine related toxicity among cocaine abusers. JF - Life sciences AU - Kumor, K AU - Sherer, M AU - Thompson, L AU - Cone, E AU - Mahaffey, J AU - Jaffe, J H AD - National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224. Y1 - 1988 PY - 1988 DA - 1988 SP - 2063 EP - 2071 VL - 42 IS - 21 SN - 0024-3205, 0024-3205 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Heart Rate -- drug effects KW - Infusions, Intravenous KW - Double-Blind Method KW - Random Allocation KW - Humans KW - Adult KW - Blood Pressure -- drug effects KW - Male KW - Cocaine -- pharmacokinetics KW - Cardiovascular System -- drug effects KW - Cocaine -- blood KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78288894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Lack+of+cardiovascular+tolerance+during+intravenous+cocaine+infusions+in+human+volunteers.&rft.au=Kumor%2C+K%3BSherer%2C+M%3BThompson%2C+L%3BCone%2C+E%3BMahaffey%2C+J%3BJaffe%2C+J+H&rft.aulast=Kumor&rft.aufirst=K&rft.date=1988-01-01&rft.volume=42&rft.issue=21&rft.spage=2063&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-29 N1 - Date created - 1988-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neoplasms of the skin and other organs observed in Swiss mice treated with nitrosoalkylureas. AN - 78281762; 3384841 AB - A number of nitrosoalkylureas, nitrosoalkylcarbamates, and chlorinated nitrosotrialkylureas were painted twice a week on the skin of female Swiss mice at a concentration of 40 mM. Of the 29 compounds, 16 induced skin tumors in 4 or more of 20 mice; 9 compounds produced tumors in 10 or more mice. Most of the skin tumors were squamous cell or basal cell carcinomas, and some sarcomas. These carcinomas and sarcomas of the skin were large, invasive, and in several animals there were multiple large metastases to the lungs and lymph nodes. Treatment with several of the compounds was associated with poor survival. The median survival in many other groups was reduced considerably below the 2-year survival of acetone-treated controls. Many of the treatments led to development of tumors of internal organs, including mammary carcinomas, adenocarcinomas and squamous cell carcinomas of the lung, and tumors of the stomach. The stomach tumors might have arisen through exposure to the compound licked from the skin. It appears that several of the compounds were absorbed through the skin of the mice and exerted their effect systemically. JF - Journal of cancer research and clinical oncology AU - Lijinsky, W AU - Reuber, M D AD - NCI-Frederick Cancer Research Facility, BRI-Basic Research Program, MD 21701. Y1 - 1988 PY - 1988 DA - 1988 SP - 245 EP - 249 VL - 114 IS - 3 SN - 0171-5216, 0171-5216 KW - Methylnitrosourea KW - 684-93-5 KW - Index Medicus KW - Animals KW - Mice KW - Lung Neoplasms -- chemically induced KW - Female KW - Administration, Topical KW - Alkylation KW - Neoplasms, Experimental -- chemically induced KW - Skin Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78281762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cancer+research+and+clinical+oncology&rft.atitle=Neoplasms+of+the+skin+and+other+organs+observed+in+Swiss+mice+treated+with+nitrosoalkylureas.&rft.au=Lijinsky%2C+W%3BReuber%2C+M+D&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1988-01-01&rft.volume=114&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Journal+of+cancer+research+and+clinical+oncology&rft.issn=01715216&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-02 N1 - Date created - 1988-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of feminization of male F344 rats on induction of tumors and on nucleic acid alkylation by nitrosobis-(2-oxopropyl)amine. AN - 78264909; 3383283 AB - Groups of male and female F344 rats were treated twice weekly by gavage with 2.5 mg of nitrosobis-(2-oxopropyl)amine (BOP) for 35 weeks. Additional groups given the same treatment were male rats castrated at birth, male rats bearing an implant of a pellet containing estradiol and castrated male rats bearing an estradiol pellet. Most rats died with tumors related to the treatment; intact male rats survived the least well of the five groups. Most rats in all groups had alveolar/bronchiolar neoplasms of the lung. Many of the male rats also had follicular cell neoplasms of the thyroid and transitional cell neoplasms of the urinary bladder and kidney pelvis; there were no liver tumors in intact male rats. Almost all female rats and castrated male rats had liver neoplasms, including hepatocellular, cholangiocellular and hemangiosarcomatous neoplasms, but few neoplasms of the thyroid, kidney or bladder. The male rats feminized with estradiol, intact or castrated, had liver neoplasms, mainly cholangiocellular, and also neoplasms of the thyroid. Two rats of each of the five groups were treated at 20 weeks of age with [14C]BOP. As measured by respiration of 14CO2, metabolism of BOP was faster in the two groups of male rats with the estradiol implant than in the other groups. DNA and RNA of the liver were isolated 6 h after treatment. The extent of methylation of liver DNA as 7-methylguanine and O6-methylguanine was higher in the females and in the feminized males than in the intact male rats, but when normalized to the dose of nitrosamine per unit body weight there was little difference among the five groups. JF - Chemico-biological interactions AU - Lijinsky, W AU - Thomas, B J AU - Kovatch, R M AD - NCI-Frederick Cancer Research Facility, BRI-Basic Research Program, MD 21701. Y1 - 1988 PY - 1988 DA - 1988 SP - 111 EP - 119 VL - 66 IS - 1-2 SN - 0009-2797, 0009-2797 KW - Nitrosamines KW - 0 KW - Estradiol KW - 4TI98Z838E KW - nitrosobis(2-oxopropyl)amine KW - 60599-38-4 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Estradiol -- pharmacology KW - Liver Neoplasms -- chemically induced KW - Lung Neoplasms -- chemically induced KW - Male KW - Female KW - Alkylation KW - Nitrosamines -- pharmacology KW - Neoplasms, Experimental -- chemically induced KW - DNA -- metabolism KW - Feminization -- complications KW - Feminization -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78264909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Effects+of+feminization+of+male+F344+rats+on+induction+of+tumors+and+on+nucleic+acid+alkylation+by+nitrosobis-%282-oxopropyl%29amine.&rft.au=Lijinsky%2C+W%3BThomas%2C+B+J%3BKovatch%2C+R+M&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1988-01-01&rft.volume=66&rft.issue=1-2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-05 N1 - Date created - 1988-08-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Chem Biol Interact 1988;67(1-2):169 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Carcinogenesis and nucleic acid alkylation by some oxygenated nitrosamines in rats and hamsters. AN - 78264567; 3383287 AB - A comparison has been made of the carcinogenic effects of nitroso-2,6-dimethylmorpholine and several hydroxylated acyclic nitrosodialkylamines derived from it or related to it in rats and Syrian hamsters. In rats nitrosodimethylmorpholine was the most potent, inducing mainly esophageal tumors. Nitrosodiethanolamine was the weakest of the five nitrosamines in both rats and hamsters. Tumors of the pancreas ducts were induced by four of the five compounds, but only in hamsters, and esophageal tumors appeared only in rats. Most of the nitrosamines induced tumors of liver and lung in both rats and hamsters. A study of alkylation of nucleic acids of the liver following treatment of rats and hamsters with the radiolabeled nitrosamines showed that nitrosodiethanolamine alkylated liver nucleic acids in rats to only a very small extent. The other four nitrosamines all gave rise to 7-methylation and O6-methylation of guanine residues in DNA of hamster liver and all but nitrosodimethylmorpholine in rat liver DNA, which corresponded quite well with the induction of liver tumors in the two species. Quantitatively, however, there was not a good correlation between liver DNA alkylation and the potency of the nitrosamine in inducing tumors. JF - Chemico-biological interactions AU - Lijinsky, W AU - Saavedra, J E AU - Kovatch, R M AD - NCI-Frederick Cancer Research Facility, BRI-Basic Research Program, MD 21701. Y1 - 1988 PY - 1988 DA - 1988 SP - 37 EP - 47 VL - 66 IS - 1-2 SN - 0009-2797, 0009-2797 KW - Nitrosamines KW - 0 KW - N-nitroso-2,6-dimethylmorpholine KW - 1456-28-6 KW - N-nitrosodiethanolamine KW - 30YI1289VY KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - diisopropanolnitrosamine KW - 4J072HB2ND KW - nitrosobis(2-oxopropyl)amine KW - 60599-38-4 KW - N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine KW - 61499-28-3 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Rats KW - Diethylnitrosamine -- analogs & derivatives KW - Administration, Oral KW - Animals KW - Rats, Inbred F344 KW - Diethylnitrosamine -- administration & dosage KW - Liver Neoplasms -- chemically induced KW - Species Specificity KW - Methylation KW - Stomach KW - Cricetinae KW - Alkylation KW - Nitrosamines -- administration & dosage KW - Neoplasms, Experimental -- chemically induced KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78264567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Carcinogenesis+and+nucleic+acid+alkylation+by+some+oxygenated+nitrosamines+in+rats+and+hamsters.&rft.au=Lijinsky%2C+W%3BSaavedra%2C+J+E%3BKovatch%2C+R+M&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1988-01-01&rft.volume=66&rft.issue=1-2&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-05 N1 - Date created - 1988-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in F344 rats by di(2-ethylhexyl)phthalate. AN - 78258578; 3378278 AB - The effects of cotreatment with a hyperlipidemic chemical, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and a hypolipidemic agent, di(2-ethylhexyl)-phthalate (DEHP), on lipid metabolism and toxicologic responses were studied in F344 rats. Treatment with TCDD alone (160 micrograms/kg) caused an increase in serum triglycerides and cholesterol while treatment with DEHP alone (2 g/kg/day) caused a decrease in triglycerides and cholesterol versus untreated controls. When administered before or after TCDD, DEHP caused a decrease in TCDD-induced hyperlipidemia. This change was attributed to enhanced hepatic peroxisomal beta-oxidation and decreased hepatic lipid synthesis resulting from treatment with DEHP. TCDD treatment produced a fatty liver, as determined by gravimetric analysis of extracted lipid and microscopic examination of liver sections which revealed extensive cytoplasmic vacuolization that stained positive with Oil Red 0, but did not induce peroxisomal beta-oxidation. Thus, an increase in hepatic or serum lipid levels is not sufficient for induction of peroxisome proliferation. Neither TCDD nor DEHP treatment affected mitochondrial beta-oxidation. Pretreatment of rats with DEHP, followed by daily exposure to this hypolipidemic agent after treatment with TCDD, had a partial protective effect against TCDD-induced fatty liver, body weight loss and mortality. Microscopic examination of liver sections confirmed the suppression of TCDD-induced fatty liver by pretreatment with DEHP. When DEHP treatment was initiated after the TCDD dose, there was less protection against the above parameters of TCDD toxicity. This study demonstrates that TCDD-induced fatty liver, hyperlipidemia and mortality can be antagonized by treatment with a hypolipidemic agent such as DEHP. JF - Chemico-biological interactions AU - Tomaszewski, K E AU - Montgomery, C A AU - Melnick, R L AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 205 EP - 222 VL - 65 IS - 3 SN - 0009-2797, 0009-2797 KW - Dioxins KW - 0 KW - Fatty Acids KW - Phthalic Acids KW - Polychlorinated Dibenzodioxins KW - Triglycerides KW - Cholesterol KW - 97C5T2UQ7J KW - Diethylhexyl Phthalate KW - C42K0PH13C KW - Oxidoreductases KW - EC 1.- KW - Acyl-CoA Oxidase KW - EC 1.3.3.6 KW - Index Medicus KW - Triglycerides -- blood KW - Microbodies -- enzymology KW - Animals KW - Liver -- pathology KW - Drug Interactions KW - Fatty Liver -- chemically induced KW - Vacuoles -- pathology KW - Liver -- metabolism KW - Fatty Acids -- metabolism KW - Rats KW - Oxidation-Reduction KW - Cholesterol -- blood KW - Rats, Inbred F344 KW - Oxidoreductases -- metabolism KW - Liver -- drug effects KW - Kinetics KW - Body Weight -- drug effects KW - Lethal Dose 50 KW - Fatty Liver -- pathology KW - Male KW - Lipid Metabolism KW - Phthalic Acids -- pharmacology KW - Polychlorinated Dibenzodioxins -- pharmacology KW - Diethylhexyl Phthalate -- toxicity KW - Polychlorinated Dibenzodioxins -- toxicity KW - Diethylhexyl Phthalate -- pharmacology KW - Dioxins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78258578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+Journal+of+Anesthesia&rft.atitle=Removing+nonessential+central+venous+catheters%3A+evaluation+of+a+quality+improvement+intervention&rft.au=Ilan%2C+Roy%2C+MD%3BDoan%2C+John%2C+MD%3BCload%2C+Bruce%2C+MD%2C+PhD%3BSquires%2C+Mae%2C+PhD%3BDay%2C+Andrew%2C+MSc&rft.aulast=Ilan&rft.aufirst=Roy&rft.date=2012-12-01&rft.volume=59&rft.issue=12&rft.spage=1102&rft.isbn=&rft.btitle=&rft.title=Canadian+Journal+of+Anesthesia&rft.issn=0832610X&rft_id=info:doi/10.1007%2Fs12630-012-9794-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-22 N1 - Date created - 1988-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chemical carcinogenesis: from animal models to molecular models in one decade. AN - 78250109; 3287845 AB - During the last decade, progress in chemical carcinogenesis research has been substantial, and understanding the cellular changes and molecular causes of initiation, promotion, and malignant conversion appears to be within reach. Cancer begins as a carcinogen-induced genetic change in a single cell. The interaction of a particular carcinogen with specific genetic sites results, in part, from selectivity of metabolically activated carcinogens for particular nucleosides or gene sequences. In turn, modification of the molecular structure at specific genetic loci will have tissue-specific and species-specific consequences dependent on the expression of a particular gene, its sequence, and the function of the gene product in the target cell. It is likely that inactivation of regulatory regions, genomic rearrangements, and point mutations in coding sequences all can result in an altered cell phenotype. The rasH gene (and perhaps other members of the ras gene family) appears to be a common target for coding sequence mutations in the initiation of carcinogenesis in several organ sites and species by specific carcinogens. Whatever genetic mechanisms are involved, an initiated cell phenotype common to many epithelial cell types is observed. Initiated cells have an altered program of terminal differentiation, are resistant to cytotoxic substances or show altered requirements for specific growth factors or nutrients. These cells would have a selective growth advantage in cytostatic or cytotoxic situations or under conditions favoring terminal differentiation. Tumor promoters, some acting through specific cellular receptors, produce a tissue environment conductive to the selective clonal outgrowth of the initiated cell population resulting in a clinically evident premalignant lesion. The tissue specificity for most promoters depends on the ability of a particular agent to produce the selective conditions required for the initiated phenotype of that organ. At the molecular level, phorbol ester tumor promoters bind to and activate protein kinase C and transduce signals through this second-messenger pathway. Heterogeneity in the species of protein kinase C molecule expressed by normal and initiated epidermal cells could account for the differential response pattern observed in these cell types during skin tumor promotion. Malignant conversion of benign tumors requires further genetic changes in the tumor cell. Such changes could result from inherent instability in the genome of initiated cells, from spontaneous mutations more likely to occur in the expanding population of proliferating benign tumor cells, or by additional exposure to exogenous genotoxic agents.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Advances in cancer research AU - Yuspa, S H AU - Poirier, M C AD - Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 25 EP - 70 VL - 50 SN - 0065-230X, 0065-230X KW - Carcinogens KW - 0 KW - Index Medicus KW - Rats KW - Animals KW - Oncogenes KW - DNA Repair KW - Carcinogens -- metabolism KW - Models, Molecular KW - Guinea Pigs KW - Humans KW - In Vitro Techniques KW - Dogs KW - Mice KW - Cricetinae KW - Neoplasms, Experimental -- chemically induced KW - Neoplasms, Experimental -- metabolism KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78250109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+cancer+research&rft.atitle=Chemical+carcinogenesis%3A+from+animal+models+to+molecular+models+in+one+decade.&rft.au=Yuspa%2C+S+H%3BPoirier%2C+M+C&rft.aulast=Yuspa&rft.aufirst=S&rft.date=1988-01-01&rft.volume=50&rft.issue=&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Advances+in+cancer+research&rft.issn=0065230X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-05 N1 - Date created - 1988-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Primary cardiac hemangiosarcomas induced by 1,3-butadiene in B6C3F1 hybrid mice. AN - 78243253; 3375747 AB - Proliferative vascular lesions of the heart were found in mice exposed chronically to 1,3-butadiene by inhalation with an overall incidence of 30% in males and 43% in females. Based on histological criteria, the lesions were subclassified as endothelial hyperplasia with an incidence of 7% in males and 13% in females and hemangiosarcoma with an incidence of 23% and 30%, respectively. A dose-relationship for both lesions was observed in females, but not in males. The absence of a dose response in males was most likely due to the lower survival rate for high-dose animals (14%) when compared to the lower-dose animals (22%). Endothelial hyperplasia was characterized by widened vascular spaces lined by a single layer of plump endothelial cells. When cellular pleomorphism and piling up of endothelial nuclei were observed, the lesion was diagnosed as hemangiosarcoma. Ultrastructural examination of hemangiosarcomas revealed lumen formation, intercellular junctions and cytoplasmic filaments. Pinocytotic vesicles which are 1 of the characteristics of endothelial cells could not be identified with certainty. Weibel-Palade bodies were not detected in the neoplastic endothelium. Metastatic lesions were observed in liver, lung and kidney. To date, 1,3-butadiene is the only carcinogen reported that induces proliferative vascular lesions in the heart of mice. JF - Toxicologic pathology AU - Solleveld, H A AU - Miller, R A AU - Banas, D A AU - Boorman, G A AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 46 EP - 52 VL - 16 IS - 1 SN - 0192-6233, 0192-6233 KW - Butadienes KW - 0 KW - 1,3-butadiene KW - JSD5FGP5VD KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Hyperplasia KW - Sex Factors KW - Microscopy, Electron KW - Mice KW - Male KW - Female KW - Heart Neoplasms -- chemically induced KW - Butadienes -- toxicity KW - Heart Neoplasms -- pathology KW - Hemangiosarcoma -- ultrastructure KW - Hemangiosarcoma -- pathology KW - Hemangiosarcoma -- chemically induced KW - Heart Neoplasms -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78243253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Primary+cardiac+hemangiosarcomas+induced+by+1%2C3-butadiene+in+B6C3F1+hybrid+mice.&rft.au=Solleveld%2C+H+A%3BMiller%2C+R+A%3BBanas%2C+D+A%3BBoorman%2C+G+A&rft.aulast=Solleveld&rft.aufirst=H&rft.date=1988-01-01&rft.volume=16&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-14 N1 - Date created - 1988-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of the multichain IL-2 receptor complex in the control of normal and malignant T-cell proliferation. AN - 78239575; 2897696 AB - Antigen-induced activation of resting T cells induces the synthesis of interleukin-2 (IL-2), as well as the expression of specific cell surface receptors for this lymphokine. There are at least two forms of the cellular receptors for IL-2, one with a very high affinity and the other with a lower affinity. We have identified two IL-2 binding peptides, a 55-kd peptide reactive with the anti-Tac monoclonal antibody and a 75-kd non-Tac IL-2 binding peptide. Cell lines bearing either the p55, Tac, or the p75 peptide alone manifested low-affinity IL-2 binding, whereas cell lines bearing both peptides manifested both high- and low-affinity receptors. Fusion of cell membranes from low-affinity IL-2 binding cells bearing the Tac peptide alone with membranes from a cell line bearing the p75 peptide alone generated hybrid membranes bearing high-affinity receptors. We propose a multichain model for the high-affinity IL-2 receptor in which both the p55 Tac and the p75 IL-2 binding peptides are associated in a receptor complex. The p75 peptide is the receptor for IL-2 on large granular lymphocytes and is sufficient for the IL-2 activation of these cells. In contrast to resting T cells, human T-cell lymphotropic virus I-associated adult T-cell leukemia cells constitutively express large numbers of IL-2 receptors. Because IL-2 receptors are present on the malignant T cells but not on normal resting cells, clinical trials have been initiated in which patients with adult T-cell leukemia are being treated with either unmodified or toxin-conjugated forms of anti-Tac monoclonal antibody directed toward this growth factor receptor. JF - Progress in clinical and biological research AU - Waldmann, T A AU - Tsudo, M AD - Metabolism Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 283 EP - 293 VL - 262 SN - 0361-7742, 0361-7742 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD27 KW - Antigens, Surface KW - Exotoxins KW - Immunotoxins KW - Receptors, Antigen, T-Cell KW - Receptors, Immunologic KW - Receptors, Interleukin-2 KW - Index Medicus KW - AIDS/HIV KW - Humans KW - Immunotoxins -- therapeutic use KW - Receptors, Antigen, T-Cell -- immunology KW - Exotoxins -- therapeutic use KW - Pseudomonas -- metabolism KW - Cloning, Molecular KW - Antibodies, Monoclonal -- therapeutic use KW - Antibodies, Monoclonal -- immunology KW - Receptors, Immunologic -- genetics KW - Deltaretrovirus Infections -- therapy KW - Deltaretrovirus Infections -- pathology KW - Deltaretrovirus Infections -- immunology KW - T-Lymphocytes -- metabolism KW - Receptors, Immunologic -- metabolism KW - Deltaretrovirus Infections -- metabolism KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78239575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=The+role+of+the+multichain+IL-2+receptor+complex+in+the+control+of+normal+and+malignant+T-cell+proliferation.&rft.au=Waldmann%2C+T+A%3BTsudo%2C+M&rft.aulast=Waldmann&rft.aufirst=T&rft.date=1988-01-01&rft.volume=262&rft.issue=&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-30 N1 - Date created - 1988-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Molecular characterization and genetic mapping of class I and class II MHC genes of the domestic cat. AN - 78226681; 2897330 AB - The major histocompatibility complex (MHC) of the domestic cat has been poorly characterized to date, primarily because of numerous difficulties in the preparation of allotypic sera. We present here a comparative analysis of class I and class II genes in domestic cat populations using molecular probes of the MHC from man and mouse. The cat possesses a minimum of 20 class I loci and 5 class II genes per haploid genome. Class I genes of the domestic cat expressed limited restriction fragment length polymorphism. The average percent difference of the size of DNA fragments between individual cats was 9.0%, a value five times lower than the value for mice, but comparable to the human DNA polymorphism level. Class I and class II genes were both genetically mapped to feline chromosome B2 using a panel of rodent x cat somatic cell hybrids. Since feline chromosome B2 is syntenically homologous to human chromosome 6 and mouse chromosome 17, these results affirm the linkage conservation of the MHC-containing linkage group in the three mammalian orders. JF - Immunogenetics AU - Yuhki, N AU - O'Brien, S J AD - Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, MD 21701-1013. Y1 - 1988 PY - 1988 DA - 1988 SP - 414 EP - 425 VL - 27 IS - 6 SN - 0093-7711, 0093-7711 KW - Index Medicus KW - Genetic Linkage KW - Mammals -- immunology KW - Animals KW - Polymorphism, Restriction Fragment Length KW - Hybrid Cells KW - Mammals -- genetics KW - Species Specificity KW - Chromosome Mapping KW - Cats -- genetics KW - Cats -- immunology KW - Major Histocompatibility Complex UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78226681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunogenetics&rft.atitle=Molecular+characterization+and+genetic+mapping+of+class+I+and+class+II+MHC+genes+of+the+domestic+cat.&rft.au=Yuhki%2C+N%3BO%27Brien%2C+S+J&rft.aulast=Yuhki&rft.aufirst=N&rft.date=1988-01-01&rft.volume=27&rft.issue=6&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=Immunogenetics&rft.issn=00937711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-29 N1 - Date created - 1988-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pulmonary elastic fiber degradation in paraquat toxicity. An electron microscopic immunohistochemical study. AN - 78225722; 3370614 AB - To study the morphologic alterations of pulmonary elastic fibers in cynomolgus monkeys with paraquat toxicity, peroxidase- and ferritin-labeled antielastin antibodies were used for the light and electron microscopic localization of elastin. One week after paraquat, alveolitis, tissue damage and alveolar dilatation were present; elastic fibers were frayed and more diffusely and intensely stained than those of control animals. In the latter, staining was localized in peripheral regions of the amorphous components and, to a lesser extent, in some microfibrils of elastic fibers. At 3 to 4 weeks, diffuse staining was evident in damaged interstitial elastic fibers and in newly formed elastic fibers in areas of intraalveolar fibrosis. At 8 weeks, the interstitium contained many elastic fibers which showed staining only in peripheral regions of the amorphous components. These observations suggest that: 1) preembedding immunohistochemical staining for elastin is localized in peripheral regions of normal elastic fibers because the antielastin antibody can penetrate into mature and undamaged amorphous components only to a very limited extent; 2) in early stages of paraquat toxicity this staining is more diffuse and intense because elastase from inflammatory cells partially degrades the elastic fibers and permits greater penetration of the antibody into the amorphous materials; 3) in later stages the staining pattern returns to normal as inflammation subsides and elastic fibers are repaired; however, newly formed elastic fibers in areas of intraalveolar fibrosis stain diffusely, reflecting increased penetration of the antibody because of immaturity and incomplete cross-linking, and 4) degeneration of elastic fibers of alveolar walls in paraquat lung may lead to alveolar dilatation, which is associated with irregular fibrosis and constitutes one of the processes of pulmonary structural remodeling in paraquat lung.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of submicroscopic cytology and pathology AU - Fukuda, Y AU - Ferrans, V J AD - Pathology Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 15 EP - 23 VL - 20 IS - 1 SN - 1122-9497, 1122-9497 KW - Elastin KW - 9007-58-3 KW - Paraquat KW - PLG39H7695 KW - Index Medicus KW - Animals KW - Macaca fascicularis KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- chemically induced KW - Pulmonary Fibrosis -- physiopathology KW - Disease Models, Animal KW - Microscopy, Electron KW - Immunohistochemistry KW - Paraquat -- pharmacology KW - Paraquat -- administration & dosage KW - Elastin -- physiology KW - Lung -- drug effects KW - Lung -- pathology KW - Elastin -- immunology KW - Paraquat -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78225722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+submicroscopic+cytology+and+pathology&rft.atitle=Pulmonary+elastic+fiber+degradation+in+paraquat+toxicity.+An+electron+microscopic+immunohistochemical+study.&rft.au=Fukuda%2C+Y%3BFerrans%2C+V+J&rft.aulast=Fukuda&rft.aufirst=Y&rft.date=1988-01-01&rft.volume=20&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Journal+of+submicroscopic+cytology+and+pathology&rft.issn=11229497&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-24 N1 - Date created - 1988-06-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Commentary on the status of short-term tests for chemical carcinogens. AN - 78221339; 3286246 JF - Environmental and molecular mutagenesis AU - Shelby, M D AU - Zeiger, E AU - Tennant, R W AD - Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 437 EP - 441 VL - 11 IS - 4 SN - 0893-6692, 0893-6692 KW - Carcinogens KW - 0 KW - Mutagens KW - Index Medicus KW - Rats KW - Animals KW - Predictive Value of Tests KW - Mice KW - Mutagens -- pharmacology KW - Carcinogens -- pharmacology KW - Mutagenicity Tests -- methods KW - Carcinogens -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78221339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Commentary+on+the+status+of+short-term+tests+for+chemical+carcinogens.&rft.au=Shelby%2C+M+D%3BZeiger%2C+E%3BTennant%2C+R+W&rft.aulast=Shelby&rft.aufirst=M&rft.date=1988-01-01&rft.volume=11&rft.issue=4&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-28 N1 - Date created - 1988-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Generation of superoxide anion and hydrogen peroxide during redox cycling of 5-(4-nitrophenyl)-penta-2,4-dienal by mammalian microsomes and enzymes. AN - 78206947; 2835186 AB - 5-(4-Nitrophenyl)penta-2,4-dienal (NPPD) stimulated NADPH-supported oxygen consumption by rat liver microsomes in a concentration-dependent manner. The NPPD stimulation of O2 uptake was not inhibited by metyrapone and was decreased in the presence of NADP+ and p-hydroxymercuribenzoate. These observations suggest that the NPPD initial reduction step is mediated by NADPH-cytochrome P-450 reductase and not by cytochrome P-450. Spin-trapping studies using 5,5-dimethyl-1-pyrroline N-oxide (DMPO) revealed the formation of superoxide anion upon incubation of NPPD, NADPH, DMPO and rat liver microsomes. Hydrogen peroxide generation was also detected in these incubations, thus confirming redox cycling of NPPD under aerobic conditions. NPPD stimulated oxygen consumption, superoxide anion formation and hydrogen peroxide generation by rat kidney, testes and brain microsomes. Other enzymes capable of nitroreduction (NADH dehydrogenase, xanthine oxidase, glutathione reductase, and NADP+ ferredoxin oxidoreductase) were also found to stimulate redox cycling of NPPD. The ability of NPPD to induce superoxide anion and hydrogen peroxide formation might play a role in its reported mutagenicity. JF - Chemico-biological interactions AU - Docampo, R AU - Moreno, S N AU - Mason, R P AD - Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, N.C. 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 123 EP - 131 VL - 65 IS - 2 SN - 0009-2797, 0009-2797 KW - Nitrobenzenes KW - 0 KW - Superoxides KW - 11062-77-4 KW - 5-(4-nitrophenyl)-2,4-pentadienal KW - 2608-48-2 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Animals KW - Oxygen Consumption -- drug effects KW - Kidney -- metabolism KW - Testis -- metabolism KW - Biotransformation KW - Microsomes, Liver -- metabolism KW - Kinetics KW - In Vitro Techniques KW - Brain -- metabolism KW - Lung -- metabolism KW - Male KW - Superoxides -- metabolism KW - Microsomes -- metabolism KW - Hydrogen Peroxide -- metabolism KW - Nitrobenzenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78206947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Generation+of+superoxide+anion+and+hydrogen+peroxide+during+redox+cycling+of+5-%284-nitrophenyl%29-penta-2%2C4-dienal+by+mammalian+microsomes+and+enzymes.&rft.au=Docampo%2C+R%3BMoreno%2C+S+N%3BMason%2C+R+P&rft.aulast=Docampo&rft.aufirst=R&rft.date=1988-01-01&rft.volume=65&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-14 N1 - Date created - 1988-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dopamine in the extrapyramidal motor function. A study based upon the MPTP-induced primate model of parkinsonism. AN - 78201856; 3259118 JF - Annals of the New York Academy of Sciences AU - Chiueh, C C AD - Clinical Brain Imaging Section, National Institute of Mental Health, Bethesda, Maryland 20892-1000. Y1 - 1988 PY - 1988 DA - 1988 SP - 226 EP - 238 VL - 515 SN - 0077-8923, 0077-8923 KW - Pyridines KW - 0 KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Macaca KW - Brain -- metabolism KW - Mice KW - Autoradiography KW - Brain -- diagnostic imaging KW - Substantia Nigra -- physiopathology KW - Corpus Striatum -- physiopathology KW - Substantia Nigra -- pathology KW - Neurons -- physiology KW - Mice, Inbred C57BL KW - Tomography, Emission-Computed KW - Corpus Striatum -- pathology KW - Female KW - Male KW - Parkinson Disease, Secondary -- physiopathology KW - Parkinson Disease, Secondary -- chemically induced KW - Parkinson Disease, Secondary -- pathology KW - Extrapyramidal Tracts -- physiology KW - Dopamine -- physiology KW - Dopamine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78201856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Dopamine+in+the+extrapyramidal+motor+function.+A+study+based+upon+the+MPTP-induced+primate+model+of+parkinsonism.&rft.au=Chiueh%2C+C+C&rft.aulast=Chiueh&rft.aufirst=C&rft.date=1988-01-01&rft.volume=515&rft.issue=&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-07 N1 - Date created - 1988-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Antitumor effect and cardiotoxicity of a doxorubicin-lecithin association. AN - 78186840; 3358634 AB - A doxorubicin-lecithin preparation was tested in vitro on B16 melanoma and Lewis lung carcinoma cells, and in vivo on C57BL/6 mice inoculated with 3LL cells. Results obtained demonstrated that the preparation possesses the same antitumor activity as doxorubicin. The cardiotoxicity of doxorubicin and of the doxorubicin-lecithin association were studied for 120 days after the end of the treatments in Wistar rats inoculated once a week for 5 weeks with equivalent doses of the drugs. Myocardial lesions were observed in both the groups of animals, but their severity and extent were reduced in rats treated with the doxorubicin-lecithin association, and their onset was also delayed. JF - Anticancer research AU - Bellelli, A AU - Giomini, M AU - Giuliani, A M AU - Giustini, M AU - Lorenzon, I AU - Rusconi, V AU - Sezzi, M L AU - Trotta, E AU - Belleli, L AD - Regina Elena National Cancer Institute, Roma, Italy. PY - 1988 SP - 177 EP - 186 VL - 8 IS - 1 SN - 0250-7005, 0250-7005 KW - Phosphatidylcholines KW - 0 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Rats KW - Animals KW - Tumor Cells, Cultured -- drug effects KW - Electrocardiography KW - Myocardium -- ultrastructure KW - Mice KW - Cardiomyopathies -- pathology KW - Carcinoma -- drug therapy KW - Melanoma, Experimental -- drug therapy KW - Doxorubicin -- administration & dosage KW - Cardiomyopathies -- chemically induced KW - Phosphatidylcholines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78186840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+research&rft.atitle=Antitumor+effect+and+cardiotoxicity+of+a+doxorubicin-lecithin+association.&rft.au=Bellelli%2C+A%3BGiomini%2C+M%3BGiuliani%2C+A+M%3BGiustini%2C+M%3BLorenzon%2C+I%3BRusconi%2C+V%3BSezzi%2C+M+L%3BTrotta%2C+E%3BBelleli%2C+L&rft.aulast=Bellelli&rft.aufirst=A&rft.date=1988-01-01&rft.volume=8&rft.issue=1&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Anticancer+research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-16 N1 - Date created - 1988-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Substrates for protein kinase C in a cell free preparation of rat aorta smooth muscles. AN - 78158552; 2832673 AB - Protein phosphorylation has been studied in a cell free system of rat aorta smooth muscles. Addition of Ca2+ caused phosphorylation of several proteins. The addition of phosphatidylserine or calmodulin together with Ca2+ further increased the phosphorylation of proteins with apparent molecular weights of 20 and 92.5 kilodaltons. The activators of protein kinase C, 12-0-tetradecanoylphorbol-13-acetate and 1,2-diolein, increased phosphorylation of the protein bands of similar molecular weight to those increased by phosphatidylserine in the presence of Ca2+, whereas the biologically inactive phorbol ester, 4 alpha-phorbol-12,13 didecanoate (4 alpha PDD) failed to change the pattern of protein phosphorylation. These results show that proteins present in smooth muscle of rat aorta with molecular weights of 20 and 92.5 kilodaltons are substrates for protein kinase C. JF - Life sciences AU - Nakaki, T AU - Wise, B C AU - Chuang, D M AD - Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032. Y1 - 1988 PY - 1988 DA - 1988 SP - 1315 EP - 1321 VL - 42 IS - 13 SN - 0024-3205, 0024-3205 KW - Calmodulin KW - 0 KW - Diglycerides KW - Phosphatidylserines KW - Phosphoproteins KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinase C KW - EC 2.7.11.13 KW - Cyclic GMP KW - H2D2X058MU KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - diolein KW - Z3MP1W91CW KW - Index Medicus KW - Animals KW - Cyclic GMP -- pharmacology KW - Calcium -- pharmacology KW - Molecular Weight KW - Rats, Inbred Strains KW - Rats KW - Diglycerides -- pharmacology KW - Phosphorylation KW - Phosphatidylserines -- pharmacology KW - Cyclic AMP -- pharmacology KW - Aorta -- enzymology KW - Enzyme Activation -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Calmodulin -- pharmacology KW - Male KW - Phosphoproteins -- metabolism KW - Cell-Free System KW - Protein Kinase C -- metabolism KW - Muscle, Smooth -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78158552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Substrates+for+protein+kinase+C+in+a+cell+free+preparation+of+rat+aorta+smooth+muscles.&rft.au=Nakaki%2C+T%3BWise%2C+B+C%3BChuang%2C+D+M&rft.aulast=Nakaki&rft.aufirst=T&rft.date=1988-01-01&rft.volume=42&rft.issue=13&rft.spage=1315&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-22 N1 - Date created - 1988-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Urinary porphyrins in children exposed transplacentally to polyhalogenated aromatics in Taiwan. AN - 78157203; 3128188 AB - In 1979, there was a large (greater than 2,000 cases) outbreak of poisoning due to contaminated rice oil in central Taiwan. The causal agent was a mixture of thermally degraded polychlorinated biphenyls (PCBs), polychlorinated quaterphenyls, and polychlorinated dibenzofurans, which had become mixed with the oil during processing. Patients remained symptomatic for several years afterward, and the chemicals persisted in their tissue. Women who became pregnant had children with high perinatal mortality and a dysmorphic syndrome. We examined urines from 75 children born to exposed mothers after the oil was confiscated, 74 controls, and 12 sibs of the exposed children. Four of the transplacentally exposed children, 2 controls, and 1 sib had a type B hepatic porphyria (i.e., uroporphyrin greater than coproporphyrin); total porphyrin excretion was elevated in the exposed children as a group (95 vs. 81 micrograms/L); and 8 of the 75 exposed children and 2 controls had total urinary porphyrin concentrations of greater than 200 micrograms/L. JF - Archives of environmental health AU - Gladen, B C AU - Rogan, W J AU - Ragan, N B AU - Spierto, F W AD - Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. PY - 1988 SP - 54 EP - 58 VL - 43 IS - 1 SN - 0003-9896, 0003-9896 KW - Porphyrins KW - 0 KW - Creatinine KW - AYI8EX34EU KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Abridged Index Medicus KW - Index Medicus KW - Skin Diseases -- urine KW - Taiwan KW - Albuminuria -- urine KW - Creatinine -- urine KW - Humans KW - Chemical and Drug Induced Liver Injury KW - Child KW - Skin Diseases -- chemically induced KW - Male KW - Female KW - Pregnancy KW - Child, Preschool KW - Porphyrins -- urine KW - Porphyrias -- chemically induced KW - Polychlorinated Biphenyls -- poisoning KW - Liver Diseases -- urine KW - Porphyrias -- urine KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78157203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+environmental+health&rft.atitle=Urinary+porphyrins+in+children+exposed+transplacentally+to+polyhalogenated+aromatics+in+Taiwan.&rft.au=Gladen%2C+B+C%3BRogan%2C+W+J%3BRagan%2C+N+B%3BSpierto%2C+F+W&rft.aulast=Gladen&rft.aufirst=B&rft.date=1988-01-01&rft.volume=43&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Archives+of+environmental+health&rft.issn=00039896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-03 N1 - Date created - 1988-05-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Erratum In: Arch Environ Health 1988 Sep-Oct;43(5):348 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Treatment of high-risk sarcomas in children and young adults: analysis of local control using intensive combined modality therapy. AN - 78156829; 3352773 AB - Although combination chemotherapy and local irradiation are quite effective treatment for some children and young adults with small round cell sarcomas, high-risk patient groups, including patients with localized disease of the trunk and proximal extremity and those who present with metastases, continue to fare poorly with standard combined modality therapy. In an attempt to improve the local and systemic response of these tumors, an intensive treatment protocol was designed that integrates five cycles of chemotherapy with vincristine, doxorubicin, and cyclophosphamide (VADRIAC) plus radiation therapy to the primary tumor (55-60 Gy), bone, and soft tissue metastases (45-50 Gy). Patients achieving complete response to this induction therapy receive intensification treatment with total body irradiation (8.0 Gy), a cycle of VADRIAC, and autologous bone marrow transplantation. All treatment is completed within 6-7 months. From January 1983 to February 1986, 76 consecutive, previously untreated patients were entered in this study; 75 patients are evaluable. Twenty-five patients were diagnosed with rhabdomyosarcoma, 23 with Ewing's sarcoma, 15 with primitive neuroepithelioma, 12 with primitive sarcoma, and 1 patient with metastatic neuroblastoma. Forty-three patients (57%) had metastases at presentation. Overall, 68 of 75 patients (91%) achieved complete response. Fifty-eight of 61 patients with measurable soft tissue masses at the primary site had greater than or equal to 50% tumor reduction with two cycles of chemotherapy prior to local irradiation. Seven patients failed to have complete response at the primary site following five cycles of chemotherapy and local external beam irradiation, although 3 were subsequently rendered locally disease free by intraoperative radiotherapy (2 patients) or surgery (1 patient).(ABSTRACT TRUNCATED AT 250 WORDS) JF - NCI monographs : a publication of the National Cancer Institute AU - Kinsella, T J AU - Miser, J S AU - Triche, T J AU - Horvath, K AU - Glatstein, E AD - Radiation Oncology Branch, National Cancer Institute, Bethesda, MD. Y1 - 1988 PY - 1988 DA - 1988 SP - 291 EP - 296 IS - 6 SN - 0893-2751, 0893-2751 KW - Vincristine KW - 5J49Q6B70F KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Doxorubicin -- adverse effects KW - Vincristine -- adverse effects KW - Combined Modality Therapy KW - Risk Factors KW - Humans KW - Adult KW - Child KW - Adolescent KW - Male KW - Female KW - Radiotherapy -- adverse effects KW - Cyclophosphamide -- adverse effects KW - Child, Preschool KW - Antineoplastic Combined Chemotherapy Protocols KW - Sarcoma -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78156829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.atitle=Treatment+of+high-risk+sarcomas+in+children+and+young+adults%3A+analysis+of+local+control+using+intensive+combined+modality+therapy.&rft.au=Kinsella%2C+T+J%3BMiser%2C+J+S%3BTriche%2C+T+J%3BHorvath%2C+K%3BGlatstein%2C+E&rft.aulast=Kinsella&rft.aufirst=T&rft.date=1988-01-01&rft.volume=&rft.issue=6&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.issn=08932751&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-03 N1 - Date created - 1988-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Malignant melanoma in the printing industry. AN - 78153760; 3354581 AB - To evaluate a recent report of malignant melanoma among printers, we used the Cancer-Environment Registry of Sweden, which links national cancer incidence and employment data. Employees in the newspaper printing industry had almost twice the incidence of melanoma than expected (p less than 0.01). Elevated risks were found not only among typographers and machine repairers, but also among journalists, editors, and business executives in the printing industry. Further studies are needed to clarify this relationship and identify specific exposures that may be responsible. JF - American journal of industrial medicine AU - McLaughlin, J K AU - Malker, H S AU - Blot, W J AU - Ericsson, J L AU - Gemne, G AU - Fraumeni, J F AD - Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 301 EP - 304 VL - 13 IS - 2 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Registries KW - Risk Factors KW - Humans KW - Sweden KW - Printing KW - Skin Neoplasms -- epidemiology KW - Occupational Diseases -- epidemiology KW - Melanoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78153760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Malignant+melanoma+in+the+printing+industry.&rft.au=McLaughlin%2C+J+K%3BMalker%2C+H+S%3BBlot%2C+W+J%3BEricsson%2C+J+L%3BGemne%2C+G%3BFraumeni%2C+J+F&rft.aulast=McLaughlin&rft.aufirst=J&rft.date=1988-01-01&rft.volume=13&rft.issue=2&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-22 N1 - Date created - 1988-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - ADP-ribosylation of guanyl nucleotide-binding regulatory proteins by bacterial toxins. AN - 78152266; 3128060 JF - Advances in enzymology and related areas of molecular biology AU - Moss, J AU - Vaughan, M AD - Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 303 EP - 379 VL - 61 SN - 0065-258X, 0065-258X KW - Bacterial Toxins KW - 0 KW - Enterotoxins KW - Escherichia coli Proteins KW - Virulence Factors, Bordetella KW - heat-labile enterotoxin, E coli KW - Adenosine Diphosphate Ribose KW - 20762-30-5 KW - Cholera Toxin KW - 9012-63-9 KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - Pentosyltransferases KW - Pertussis Toxin KW - EC 2.4.2.31 KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - GTP-Binding Proteins KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Index Medicus KW - Neutrophils -- drug effects KW - Animals KW - Adenylyl Cyclases -- analysis KW - Humans KW - GTP Phosphohydrolases -- analysis KW - Enterotoxins -- pharmacology KW - Bacterial Toxins -- pharmacology KW - Pentosyltransferases -- analysis KW - Virulence Factors, Bordetella -- pharmacology KW - GTP-Binding Proteins -- metabolism KW - Cholera Toxin -- pharmacology KW - Adenosine Diphosphate Ribose -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78152266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+enzymology+and+related+areas+of+molecular+biology&rft.atitle=ADP-ribosylation+of+guanyl+nucleotide-binding+regulatory+proteins+by+bacterial+toxins.&rft.au=Moss%2C+J%3BVaughan%2C+M&rft.aulast=Moss&rft.aufirst=J&rft.date=1988-01-01&rft.volume=61&rft.issue=&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Advances+in+enzymology+and+related+areas+of+molecular+biology&rft.issn=0065258X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-29 N1 - Date created - 1988-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative toxicity and renal distribution of the platinum analogs tetraplatin, CHIP, and cisplatin at equimolar doses in the Fischer 344 rat. AN - 78151602; 3350229 AB - Tetraplatin [tetrachloro(dl-trans)1,2-diaminocyclohexane platinum(IV), NSC-363812] is a new anticancer platinum drug analog targeted for clinical development because of its effectiveness against cisplatin-resistant tumor cell lines and its improved formulation. The toxicity of tetraplatin was compared at equimolar doses to that of cisplatin [cis-diamminedichlorophatinum(II)] and CHIP [cis-dichloro,trans-dihydroxybis-isopropylamine platinum(IV), NSC-256927]. Adult male Fischer 344 rats received an iv bolus injection of 6.7, 13.3, 26.7, or 53.3 mumol/kg of one of these drugs in saline and were killed on Day 1, 3, 5, 8, or 15 postinjection for assessment of toxicity with emphasis on evaluation of nephrotoxicity. Rats to be killed on Day 15 were housed in metabolism cages for daily urine collection. Tetraplatin was less nephrotoxic than cisplatin at equimolar doses; CHIP was not nephrotoxic at these doses. Renal platinum contents were similar after all three drugs and did not appear to be related directly to the nephrotoxicity. Nephrotoxicity was detected 4-5 days after 6.7 mumol/kg cisplatin, was localized to the corticomedullary junction, and progressed with time and dose. Tetraplatin-induced alterations of renal function were first observed after 13.4 mumol/kg on Day 4 as an elevation of urine volume (up to 10-fold) and a smaller elevation of urinary glucose excretion. Tetraplatin lesions were localized in the mid- and outer cortex and, even at the highest dose, were less severe than those observed with cisplatin. There were other prominent toxic effects of tetraplatin, such as gastrointestinal toxicity and myelosuppression, which indicate that factors other than comparative nephrotoxicity may impact the clinical potential of this new agent. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Smith, J H AU - Smith, M A AU - Litterst, C L AU - Copley, M P AU - Uozumi, J AU - Boyd, M R AD - Laboratory of Experimental Therapeutics and Metabolism, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 45 EP - 61 VL - 10 IS - 1 SN - 0272-0590, 0272-0590 KW - Antineoplastic Agents KW - 0 KW - Organoplatinum Compounds KW - iproplatin KW - 5R9F9NE9Z2 KW - Cisplatin KW - Q20Q21Q62J KW - ormaplatin KW - SFK1SGY8V1 KW - Index Medicus KW - Rats KW - Kidney Diseases -- pathology KW - Animals KW - Rats, Inbred F344 KW - Digestive System -- drug effects KW - Body Weight -- drug effects KW - Male KW - Kidney Diseases -- chemically induced KW - Cisplatin -- pharmacokinetics KW - Organoplatinum Compounds -- pharmacokinetics KW - Kidney -- metabolism KW - Kidney -- pathology KW - Cisplatin -- toxicity KW - Antineoplastic Agents -- pharmacokinetics KW - Antineoplastic Agents -- toxicity KW - Organoplatinum Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78151602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Comparative+toxicity+and+renal+distribution+of+the+platinum+analogs+tetraplatin%2C+CHIP%2C+and+cisplatin+at+equimolar+doses+in+the+Fischer+344+rat.&rft.au=Smith%2C+J+H%3BSmith%2C+M+A%3BLitterst%2C+C+L%3BCopley%2C+M+P%3BUozumi%2C+J%3BBoyd%2C+M+R&rft.aulast=Smith&rft.aufirst=J&rft.date=1988-01-01&rft.volume=10&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-26 N1 - Date created - 1988-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lack of cage effects on liver tumor incidence in B6C3F1 mice. AN - 78145744; 3350226 AB - Twenty-three chemicals evaluated as hepatocarcinogens in B6C3F1 mice by the National Toxicology Program (NTP) and nine showing equivocal liver tumor effects were examined to determine if the occurrence of liver neoplasms was associated with caging, i.e., if there were significant differences in tumor incidence among cages. A total of 79 dosed groups showing increased liver tumor incidence were evaluated. The analysis showed that the number of instances in which liver tumors showed significant cage effects agreed closely with chance expectation. Experimental design protocols now utilized by the NTP (including random assignment of columns of cages to dosed and control groups, periodic rotation of cage location, and individual caging of mice) further reduce the likelihood that factors associated with the housing of the animals could influence tumor incidence. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Haseman, J K AD - Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 179 EP - 187 VL - 10 IS - 1 SN - 0272-0590, 0272-0590 KW - Carcinogens KW - 0 KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Mice KW - Male KW - Female KW - Liver Neoplasms, Experimental -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78145744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Lack+of+cage+effects+on+liver+tumor+incidence+in+B6C3F1+mice.&rft.au=Haseman%2C+J+K&rft.aulast=Haseman&rft.aufirst=J&rft.date=1988-01-01&rft.volume=10&rft.issue=1&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-26 N1 - Date created - 1988-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phase III trial of irradiation plus chemotherapy for patients with hepatic metastases and hepatoma: experience of the Northern California Oncology Group. AN - 78144980; 2832763 AB - The effects of iv or intra-arterial chemotherapy added to hepatic irradiation were evaluated in a 3-arm randomized trial. Patients with predominantly hepatic metastases or with hepatoma were eligible. They were randomized to receive 2,100 cGy in seven fractions alone or with 5-fluorouracil given either intra-arterially or by iv infusion; doxorubicin and mitomycin were given by bolus simultaneously with the radiation in a single course. A total of 166 patients were entered in the study. Toxicity was acceptable, with no sign of enhanced radiation damage. Response was evaluated 4-6 weeks after treatment. No complete responses were seen, but partial responses greater than or equal to 50% were observed in the groups treated with radiation only (17%), radiation plus drug given iv (25%), and radiation plus drug given intra-arterially (20%) (P greater than .3). Disease progression occurred in a larger number of patients who received radiation only (29%) at 6 weeks than in the other 2 groups (7% and 18%, respectively; P less than .03). Thus, in terms of local response duration, the addition of chemotherapy enhanced the effect of the radiation. Survival was not different among the 3 groups. JF - NCI monographs : a publication of the National Cancer Institute AU - Friedman, M A AU - Phillips, T L AU - Hannigan, J F AU - Carter, S K AD - Division of Cancer Treatment, National Cancer Institute, Bethesda, MD. Y1 - 1988 PY - 1988 DA - 1988 SP - 259 EP - 264 IS - 6 SN - 0893-2751, 0893-2751 KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Fluorouracil -- administration & dosage KW - Combined Modality Therapy KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Male KW - Female KW - Liver Neoplasms -- therapy KW - Carcinoma, Hepatocellular -- secondary KW - Liver Neoplasms -- mortality KW - Carcinoma, Hepatocellular -- therapy KW - Liver Neoplasms -- secondary KW - Carcinoma, Hepatocellular -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78144980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.atitle=Phase+III+trial+of+irradiation+plus+chemotherapy+for+patients+with+hepatic+metastases+and+hepatoma%3A+experience+of+the+Northern+California+Oncology+Group.&rft.au=Friedman%2C+M+A%3BPhillips%2C+T+L%3BHannigan%2C+J+F%3BCarter%2C+S+K&rft.aulast=Friedman&rft.aufirst=M&rft.date=1988-01-01&rft.volume=&rft.issue=6&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.issn=08932751&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-03 N1 - Date created - 1988-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Behavioral interactions between ethanol and imidazodiazepines with high affinities for benzodiazepine receptors. AN - 78144479; 2832675 AB - The intrinsic effects of two imidazodiazepines RO 15-3505 and RO 17-1812 on the behavior of mice in a holeboard test were investigated. The interactions of these two drugs with ethanol were also studied. RO 15-3505 (0.75-6.0 mg/kg) failed to significantly alter either exploratory head-dipping or locomotor activity when administered alone but doses of 0.75 and 1.5 mg/kg reversed the reduction in the number of head-dips caused by ethanol (2 g/kg) and partially reversed ethanol's locomotor stimulant action. In contrast, RO 17-1812 (0.75-6.0 mg/kg) increased locomotor activity when administered alone, and enhanced the reduction in exploration caused by ethanol. Neither RO 15-3505 nor RO 17-1812 altered blood alcohol concentrations suggesting a pharmacodynamic basis for these interactions. The results suggest that in the holeboard test the interactions of imidazodiazepines with ethanol are related to the nature of their interaction with benzodiazepine receptors, inverse agonists antagonising and agonists enhancing ethanol's effects on exploration. JF - Life sciences AU - Lister, R G AD - Laboratory of Clinical Studies, NIAAA, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 1385 EP - 1393 VL - 42 IS - 14 SN - 0024-3205, 0024-3205 KW - Benzodiazepinones KW - 0 KW - Receptors, GABA-A KW - Benzodiazepines KW - 12794-10-4 KW - Ethanol KW - 3K9958V90M KW - Ro 15-3505 KW - 78756-33-9 KW - Ro 17-1812 KW - 90450-01-4 KW - Index Medicus KW - Animals KW - Drug Interactions KW - Receptors, GABA-A -- physiology KW - Benzodiazepines -- antagonists & inhibitors KW - Receptors, GABA-A -- drug effects KW - Motor Activity -- drug effects KW - Mice KW - Male KW - Ethanol -- blood KW - Behavior, Animal -- drug effects KW - Ethanol -- pharmacology KW - Benzodiazepinones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78144479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Behavioral+interactions+between+ethanol+and+imidazodiazepines+with+high+affinities+for+benzodiazepine+receptors.&rft.au=Lister%2C+R+G&rft.aulast=Lister&rft.aufirst=R&rft.date=1988-01-01&rft.volume=42&rft.issue=14&rft.spage=1385&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-25 N1 - Date created - 1988-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vivo biochemical indices of nephrotoxicity of platinum analogs tetraplatin, CHIP, and cisplatin in the Fischer 344 rat. AN - 78138984; 3350230 AB - In vivo biochemical indices of nephrotoxicity were investigated in Fischer 344 rats treated with a new platinum analog, tetraplatin [tetrachloro(dl-trans)1,2-diaminocyclohexane platinum(IV), NSC-363812], in comparison with rats receiving equimolar dosages of cisplatin and CHIP [cis-dichloro,trans-dihydroxybis-isopropylamine platinum(IV), NSC-256927]. The goals of this study were to assess the comparative nephrotoxicities and to determine which battery of tests might be useful for the assessment of platinum analog-induced nephrotoxicity in future clinical investigations of these drugs. An iv bolus injection of 6.7, 13.3, 26.7, and 53.3 mumol/kg of each drug in saline was administered and assessment of biochemical parameters was conducted for 15 days postinjection. A combination of urinary enzyme and protein excretion rates along with blood urea nitrogen (BUN) determinations was used to assess the nephrotoxicity of these compounds. At equimolar dosages, tetraplatin appeared to be less nephrotoxic than cisplatin, and CHIP was not nephrotoxic. At all dosages tested, cisplatin increased the rate of urinary excretion of protein, lactate dehydrogenase (LDH), and N-acetylglucosaminidase (NAG) between Days 1 and 5. Tetraplatin did not affect these parameters until the 13.3 mumol/kg dosage. Cisplatin had little effect on the excretion rates of the brush border enzymes alkaline phosphatase and maltase, whereas tetraplatin caused an initial elevation with delayed onset of peak excretion rates at 8 days postinjection. Changes in BUN were not evident until after the 13.3 mumol/kg dosage of cisplatin and the 26.7 mumol/kg dosage of tetraplatin. BUN was useful for ranking the relative toxicities of the three compounds tested, but was not as sensitive in detecting the onset of injury that correlated with early histopathological changes. Tetraplatin appeared to be less nephrotoxic than cisplatin on an equimolar basis and the specific manifestations of its toxicity were different from those observed with cisplatin. Urinary excretion rates for LDH, NAG, and protein proved to be sensitive indicators of platinum analog-induced nephrotoxicity. These indices, combined with BUN determinations and functional assessments, facilitated comparisons of the nephrotoxicity induced by cisplatin and tetraplatin in rats. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Smith, M A AU - Smith, J H AU - Litterst, C L AU - Copley, M P AU - Uozumi, J AU - Boyd, M R AD - Laboratory of Experimental Therapeutics and Metabolism, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 62 EP - 72 VL - 10 IS - 1 SN - 0272-0590, 0272-0590 KW - Antineoplastic Agents KW - 0 KW - Electrolytes KW - Organoplatinum Compounds KW - iproplatin KW - 5R9F9NE9Z2 KW - Cisplatin KW - Q20Q21Q62J KW - ormaplatin KW - SFK1SGY8V1 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Proteinuria -- urine KW - Blood Urea Nitrogen KW - Electrolytes -- urine KW - Male KW - Proteinuria -- chemically induced KW - Kidney Diseases -- pathology KW - Cisplatin -- toxicity KW - Antineoplastic Agents -- toxicity KW - Organoplatinum Compounds -- toxicity KW - Kidney Diseases -- enzymology KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78138984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=In+vivo+biochemical+indices+of+nephrotoxicity+of+platinum+analogs+tetraplatin%2C+CHIP%2C+and+cisplatin+in+the+Fischer+344+rat.&rft.au=Smith%2C+M+A%3BSmith%2C+J+H%3BLitterst%2C+C+L%3BCopley%2C+M+P%3BUozumi%2C+J%3BBoyd%2C+M+R&rft.aulast=Smith&rft.aufirst=M&rft.date=1988-01-01&rft.volume=10&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-26 N1 - Date created - 1988-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Control of parathyroid (PTH) secretion is mediated through calcium channels. AN - 78135963; 2450376 JF - Progress in clinical and biological research AU - Fitzpatrick, L A AU - Aurbach, G D AD - Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 47 EP - 52 VL - 252 SN - 0361-7742, 0361-7742 KW - Calcium Channel Agonists KW - 0 KW - Calcium Channel Blockers KW - Ion Channels KW - Marine Toxins KW - Nicotinic Acids KW - Oxadiazoles KW - Oxocins KW - Parathyroid Hormone KW - PN 202-791 KW - 101342-80-7 KW - maitotoxin KW - 9P59GES78D KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Marine Toxins -- pharmacology KW - Animals KW - Nicotinic Acids -- pharmacology KW - Cattle KW - Calcium Channel Blockers -- pharmacology KW - Parathyroid Glands -- metabolism KW - In Vitro Techniques KW - Parathyroid Glands -- drug effects KW - Parathyroid Glands -- secretion KW - Calcium Channel Agonists -- pharmacology KW - Calcium -- metabolism KW - Parathyroid Hormone -- secretion KW - Ion Channels -- drug effects KW - Ion Channels -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78135963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Control+of+parathyroid+%28PTH%29+secretion+is+mediated+through+calcium+channels.&rft.au=Fitzpatrick%2C+L+A%3BAurbach%2C+G+D&rft.aulast=Fitzpatrick&rft.aufirst=L&rft.date=1988-01-01&rft.volume=252&rft.issue=&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-08 N1 - Date created - 1988-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pathological and biochemical effects of dimethyl hydrogen phosphite in Fischer 344 rats. AN - 78135935; 2832231 AB - In a chronic study by the National Toxicology Program (NTP), dimethyl hydrogen phosphite (DMHP) caused neoplastic and nonneoplastic changes in the lungs and forestomach of F344/N rats following gavage administration for 2 years. The current investigation was designed to study the effect of a short-term exposure on a series of biochemical systems in target and nontarget tissues which may be involved in the metabolism and/or the manifestation of DMHP toxicity. Rats were treated daily with a dose similar to that used in the NTP study (200 mg/kg) for 4, 5, or 6 weeks. Two groups of animals were also treated for 4 weeks and then treatment was discontinued and the rats were allowed to recover for 1 or 2 weeks. An equal number of animals was treated similarly with the vehicle and used as control. The microsomal and soluble fractions were separated from liver, lungs, kidneys, forestomach, and glandular stomach from the 6-week treatment group. Another group of rats treated for 6 weeks was prepared for pathology examination of the lungs, forestomach, and glandular stomach. There was a significant increase in the weight of the forestomach of rats treated for 4, 5, or 6 weeks relative to control animals, while no significant difference was observed in the weight of liver, lungs, kidneys, and glandular stomach. The forestomach weight of rats treated for 4 weeks returned to the control value after 1 week of recovery. Microscopic examination of the forestomach of rats treated for 6 weeks revealed a thickened stratified squamous epithelium characterized by hyperplasia, hyperkeratosis, and subepithelial inflammation and edema. There were no microscopic changes in the lungs or glandular stomach of animals treated for 6 weeks. The activity of angiotensin converting enzyme in the serum of rats treated for 4, 5, or 6 weeks was significantly increased over that of control animals. The activity of this enzyme returned to near levels seen in the control animals after 1 week of recovery following 4 weeks of treatment. No treatment-related effect was observed in the activities of the microsomal p-nitroanisole demethylase, soluble glutathione S-transferase, and soluble superoxide dismutase in the five tissues studied. There was a significant increase in the level of nonprotein soluble sulfhydryls in the forestomach but in no other tissue of rats treated for 6 weeks. Also the activity of soluble carboxylesterase was significantly reduced in the lungs and forestomach, but not in any other tissue of the 6-week-treated rats.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Nomeir, A A AU - Uraih, L C AD - Toxicology Research and Testing Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 114 EP - 124 VL - 10 IS - 1 SN - 0272-0590, 0272-0590 KW - Carcinogens KW - 0 KW - Organophosphonates KW - Organophosphorus Compounds KW - Phosphites KW - Sulfhydryl Compounds KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Nitroanisole O-Demethylase KW - EC 1.- KW - Carboxylic Ester Hydrolases KW - EC 3.1.1.- KW - Peptidyl-Dipeptidase A KW - EC 3.4.15.1 KW - dimethyl hydrogen phosphite KW - ST4TBO000H KW - Index Medicus KW - Animals KW - Carboxylic Ester Hydrolases -- metabolism KW - Sulfhydryl Compounds -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Rats KW - Rats, Inbred F344 KW - Nitroanisole O-Demethylase -- metabolism KW - Stomach -- metabolism KW - Peptidyl-Dipeptidase A -- metabolism KW - Male KW - Stomach -- enzymology KW - Organ Size -- drug effects KW - Organophosphorus Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78135935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Pathological+and+biochemical+effects+of+dimethyl+hydrogen+phosphite+in+Fischer+344+rats.&rft.au=Nomeir%2C+A+A%3BUraih%2C+L+C&rft.aulast=Nomeir&rft.aufirst=A&rft.date=1988-01-01&rft.volume=10&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-26 N1 - Date created - 1988-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Potential metabolic basis for enflurane hepatitis and the apparent cross-sensitization between enflurane and halothane. AN - 78133819; 2894942 AB - Clinical case reports of unexplained hepatic dysfunction following enflurane and isoflurane anesthesia led to the hypothesis that oxidative metabolism of these drugs by cytochromes P-450 produces immunoreactive, covalently bound acylated protein adducts similar to those implicated in the genesis of halothane-induced hepatic necrosis. Microsomal adducts were detected by enzyme-linked immunosorbent assay and immunoblotting techniques utilizing specific anti-trifluoroacetyl (TFA) IgG hapten antibodies in rat liver following enflurane, isoflurane, or halothane administration. Preincubation of the antibodies with microsomes from halothane-pretreated rats or with 500 microM TFA-lysine, markedly inhibited adduct recognition, while preincubation with 500 microM acetyllysine had no effect. The relative amounts of immunoreactive protein adducts formed were halothane much greater than enflurane much greater than isoflurane and correlates directly with the relative extents of metabolism of these agents. These results support the view that acyl metabolites of the volatile anesthetics may become covalently bound to hepatic proteins, thus serving as antigens, and thereby account for the apparent cross-sensitization and idiosyncratic hepatotoxicity reported for these drugs. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Christ, D D AU - Satoh, H AU - Kenna, J G AU - Pohl, L R AD - Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892. PY - 1988 SP - 135 EP - 140 VL - 16 IS - 1 SN - 0090-9556, 0090-9556 KW - Immunoglobulin G KW - 0 KW - Sodium Dodecyl Sulfate KW - 368GB5141J KW - Enflurane KW - 91I69L5AY5 KW - Isoflurane KW - CYS9AKD70P KW - Halothane KW - UQT9G45D1P KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Immunoglobulin G -- analysis KW - Isoflurane -- metabolism KW - Electrophoresis, Polyacrylamide Gel KW - Biotransformation KW - Microsomes, Liver -- metabolism KW - Enzyme-Linked Immunosorbent Assay KW - Acylation KW - Male KW - Enflurane -- metabolism KW - Chemical and Drug Induced Liver Injury -- etiology KW - Halothane -- toxicity KW - Enflurane -- toxicity KW - Chemical and Drug Induced Liver Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78133819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=Potential+metabolic+basis+for+enflurane+hepatitis+and+the+apparent+cross-sensitization+between+enflurane+and+halothane.&rft.au=Christ%2C+D+D%3BSatoh%2C+H%3BKenna%2C+J+G%3BPohl%2C+L+R&rft.aulast=Christ&rft.aufirst=D&rft.date=1988-01-01&rft.volume=16&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-27 N1 - Date created - 1988-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Development of a testing battery to assess chemical-induced immunotoxicity: National Toxicology Program's guidelines for immunotoxicity evaluation in mice. AN - 78132010; 3280374 JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Luster, M I AU - Munson, A E AU - Thomas, P T AU - Holsapple, M P AU - Fenters, J D AU - White, K L AU - Lauer, L D AU - Germolec, D R AU - Rosenthal, G J AU - Dean, J H AD - Systemic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 2 EP - 19 VL - 10 IS - 1 SN - 0272-0590, 0272-0590 KW - Index Medicus KW - Animals KW - Toxicology -- standards KW - Reference Standards KW - Mice KW - Immunity -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78132010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Development+of+a+testing+battery+to+assess+chemical-induced+immunotoxicity%3A+National+Toxicology+Program%27s+guidelines+for+immunotoxicity+evaluation+in+mice.&rft.au=Luster%2C+M+I%3BMunson%2C+A+E%3BThomas%2C+P+T%3BHolsapple%2C+M+P%3BFenters%2C+J+D%3BWhite%2C+K+L%3BLauer%2C+L+D%3BGermolec%2C+D+R%3BRosenthal%2C+G+J%3BDean%2C+J+H&rft.aulast=Luster&rft.aufirst=M&rft.date=1988-01-01&rft.volume=10&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-26 N1 - Date created - 1988-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants. AN - 78126904; 3349229 AB - 1. The proconvulsant effects of the imidazodiazepine Ro 15-4513, were investigated in mice by use of intravenous infusion of a variety of convulsant drugs. 2. Dose-response and time course studies of Ro 15-4513 against gamma-aminobutyric acid (GABA) antagonists were performed. On the basis of these studies a maximally effective dose of 5 mg kg-1 was administered 5 min before the determination of seizure thresholds in subsequent experiments. 3. Ro 15-4513 (5 mg kg-1) significantly lowered seizure thresholds to pentylenetetrazole, bicuculline and the convulsant benzodiazepine Ro 5-3663, but failed to alter seizure thresholds to picrotoxin, strychnine, caffeine and quipazine. 4. Ro 15-4513 significantly raised seizure threshold to the benzodiazepine receptor inverse agonist methyl 6,7-dimethoxy-4 ethyl-beta-carboline-3-carboxylate (DMCM). 5. These results are discussed in relation to other studies investigating the proconvulsant and alcohol-antagonizing effects of Ro 15-4513. JF - British journal of pharmacology AU - Lister, R G AU - Nutt, D J AD - Laboratory of Clinical Studies, DICBR, NIAAA, Bethesda, MD 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 210 EP - 214 VL - 93 IS - 1 SN - 0007-1188, 0007-1188 KW - Azides KW - 0 KW - Benzodiazepinones KW - Carbolines KW - Convulsants KW - Picrotoxin KW - 124-87-8 KW - Benzodiazepines KW - 12794-10-4 KW - methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate KW - 1309288N1J KW - Ro 5-3663 KW - 70656-87-0 KW - Ro 15-4513 KW - 91917-65-6 KW - Pentylenetetrazole KW - WM5Z385K7T KW - Bicuculline KW - Y37615DVKC KW - Index Medicus KW - Seizures -- chemically induced KW - Animals KW - Drug Interactions KW - Benzodiazepinones -- antagonists & inhibitors KW - Picrotoxin -- antagonists & inhibitors KW - Seizures -- physiopathology KW - Mice KW - Bicuculline -- antagonists & inhibitors KW - Pentylenetetrazole -- antagonists & inhibitors KW - Male KW - Carbolines -- antagonists & inhibitors KW - Convulsants -- pharmacology KW - Azides -- pharmacology KW - Benzodiazepines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78126904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+pharmacology&rft.atitle=Interactions+of+the+imidazodiazepine+Ro+15-4513+with+chemical+convulsants.&rft.au=Lister%2C+R+G%3BNutt%2C+D+J&rft.aulast=Lister&rft.aufirst=R&rft.date=1988-01-01&rft.volume=93&rft.issue=1&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=British+journal+of+pharmacology&rft.issn=00071188&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-28 N1 - Date created - 1988-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1974 Jun;71(6):2246-50 [4152296] Science. 1986 Dec 5;234(4781):1243-7 [3022383] Neuropharmacology. 1980 Oct;19(10):1017-23 [7422073] Brain Res. 1981 Jul 20;216(2):399-408 [6113878] Eur J Pharmacol. 1981 May 8;71(2-3):287-95 [6113969] J Neurochem. 1981 Jul;37(1):1-13 [6265597] Proc Natl Acad Sci U S A. 1981 May;78(5):3260-4 [6265942] Eur J Pharmacol. 1982 Jun 4;80(4):347-58 [6286323] Psychopharmacology (Berl). 1982;78(3):293-5 [6296905] Eur J Pharmacol. 1983 Jan 28;87(1):155-8 [6301850] J Neurochem. 1984 Jan;42(1):221-9 [6689688] Brain Res. 1984 Jan 2;290(1):183-6 [6419985] Eur J Pharmacol. 1984 Jan 27;97(3-4):289-93 [6423394] Eur J Pharmacol. 1984 Aug 17;103(3-4):359-62 [6092108] Br J Pharmacol. 1984 Dec;83(4):951-8 [6097329] Br J Pharmacol. 1985 Oct;86(2):465-73 [2932195] Eur J Pharmacol. 1986 Mar 18;122(2):161-5 [2872063] J Pharm Pharmacol. 1986 Sep;38(9):697-8 [2877073] Neuropharmacology. 1976 Mar;15(3):173-9 [132619] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Control of smoking in occupational epidemiologic studies: methods and needs. AN - 78124197; 3344754 JF - American journal of industrial medicine AU - Blair, A AU - Steenland, K AU - Shy, C AU - O'Berg, M AU - Halperin, W AU - Thomas, T AD - Occupational Studies Section, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 3 EP - 4 VL - 13 IS - 1 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Risk Factors KW - Humans KW - Epidemiologic Methods KW - Occupational Diseases -- etiology KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78124197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Control+of+smoking+in+occupational+epidemiologic+studies%3A+methods+and+needs.&rft.au=Blair%2C+A%3BSteenland%2C+K%3BShy%2C+C%3BO%27Berg%2C+M%3BHalperin%2C+W%3BThomas%2C+T&rft.aulast=Blair&rft.aufirst=A&rft.date=1988-01-01&rft.volume=13&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-25 N1 - Date created - 1988-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Indirect corrections for confounding under multiplicative and additive risk models. AN - 78124158; 3344751 AB - We define a multiplicative model and an additive model for the hazards associated jointly with exposure and with the presence of a confounder like smoking. Under the multiplicative model, the crude relative risk may be adjusted indirectly, by means of a factor proposed by Axelson [1978], and implicitly by Cornfield et al. [1959] and Schlesselman [1978]. We present corresponding indirect correction formulas under the additive risk model for the risk difference and for the excess relative risk. Conditions are established under which these corrections may be applied to age-adjusted rates from composite study populations. We demonstrate that indirect corrections may be no better than crude measures of risk if one assumes the wrong model for the joint action of the exposure and confounding factors. These results are illustrated on an example of occupational exposure to vermiculite. The limitations of the techniques are discussed. JF - American journal of industrial medicine AU - Gail, M H AU - Wacholder, S AU - Lubin, J H AD - Epidemiologic Methods Section, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 119 EP - 130 VL - 13 IS - 1 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Risk Factors KW - Humans KW - Lung Neoplasms -- mortality KW - Models, Theoretical KW - Epidemiologic Methods KW - Occupational Diseases -- etiology KW - Smoking -- epidemiology KW - Mathematics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78124158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Indirect+corrections+for+confounding+under+multiplicative+and+additive+risk+models.&rft.au=Gail%2C+M+H%3BWacholder%2C+S%3BLubin%2C+J+H&rft.aulast=Gail&rft.aufirst=M&rft.date=1988-01-01&rft.volume=13&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-25 N1 - Date created - 1988-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Relative risk models for assessing the joint effects of multiple factors. AN - 78123298; 3344753 AB - A goal of analyses of occupational cohort data is the specification of how covariate information relates to age-specific disease risks. In describing this relationship, certain assumptions or models must be defined. For example, the usual standardized mortality ratio assumes a constant multiplicative increase in the age and calendar period disease rates of an exposed cohort over rates in a unexposed referent group. For analyzing several exposures, some of which may be continuous, such as cumulative dose, dose rate, duration of employment, and smoking patterns, or for analyzing complex associations between disease rate and covariates, flexible regression procedures are required. Using a crossclassification of the data and a Poisson probability model, relative risk regression methods are outlined. Breslow and Storer [1985], Guerrero and Johnson [1982], and Thomas [1981] propose general models for the relative risk as alternatives to, but which include, the usual exponential form. We review these models, discuss some limitations (in particular when there is more than one covariate) and present alternatives. Methods and models are illustrated by examining the joint effects of radon exposure and tobacco use on lung cancer mortality among a group of uranium miners. JF - American journal of industrial medicine AU - Lubin, J H AU - Gaffey, W AD - Biostatics Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 149 EP - 167 VL - 13 IS - 1 SN - 0271-3586, 0271-3586 KW - Uranium KW - 4OC371KSTK KW - Radon KW - Q74S4N8N1G KW - Index Medicus KW - Age Factors KW - Humans KW - Aged KW - Radon -- adverse effects KW - Smoking -- epidemiology KW - Lung Neoplasms -- etiology KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Neoplasms, Radiation-Induced KW - Middle Aged KW - Mining KW - Models, Theoretical KW - Epidemiologic Methods KW - Statistics as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78123298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Relative+risk+models+for+assessing+the+joint+effects+of+multiple+factors.&rft.au=Lubin%2C+J+H%3BGaffey%2C+W&rft.aulast=Lubin&rft.aufirst=J&rft.date=1988-01-01&rft.volume=13&rft.issue=1&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-25 N1 - Date created - 1988-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. AN - 78120865; 3277844 AB - Three hundred chemicals were tested for mutagenicity, under code, in Salmonella typhimurium, using a preincubation protocol. All tests were performed in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclor-induced male Sprague-Dawley rats and Syrian hamsters. The results and data from these tests are presented. JF - Environmental and molecular mutagenesis AU - Zeiger, E AU - Anderson, B AU - Haworth, S AU - Lawlor, T AU - Mortelmans, K AD - Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. Y1 - 1988 PY - 1988 DA - 1988 SP - 1 EP - 157 VL - 11 Suppl 12 SN - 0893-6692, 0893-6692 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Chemistry KW - Biotransformation KW - Microsomes, Liver -- metabolism KW - Chemical Phenomena KW - Mesocricetus KW - Male KW - Cricetinae KW - Mutagenicity Tests KW - Salmonella typhimurium -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78120865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Salmonella+mutagenicity+tests%3A+IV.+Results+from+the+testing+of+300+chemicals.&rft.au=Zeiger%2C+E%3BAnderson%2C+B%3BHaworth%2C+S%3BLawlor%2C+T%3BMortelmans%2C+K&rft.aulast=Zeiger&rft.aufirst=E&rft.date=1988-01-01&rft.volume=11+Suppl+12&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-28 N1 - Date created - 1988-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pulmonary macrophages are attracted to inhaled particles through complement activation. AN - 78120748; 2830106 AB - Pulmonary macrophages play a central role in clearing inhaled particles from the lung. Previously, we showed that inhaled asbestos fibers activate complement-dependent chemotactic factors on alveolar surfaces to facilitate macrophage recruitment to sites of fiber deposition. In the studies presented here, we have tested a variety of inorganic particles for complement activation in vitro and correlated these data with results on particle-induced macrophage accumulation in vivo. We found that significant chemotactic activity was activated in rat serum and concentrated lavaged proteins by chrysotile and crocidolite asbestos, iron-coated chrysotile asbestos, fiberglass, and wollastonite fibers, as well as by carbonyl iron and zymosan particles. Ash from the Mt. St. Helens volcano did not induce chemotactic activity in either the serum or lavaged proteins. Rats were exposed to brief aerosols of each of the particles listed above (except zymosan). All the particle types studied were deposited primarily at first alveolar duct bifurcations. In addition, all of the particles, except Mt. St. Helens ash, induced at 48 h postexposure significant accumulations of macrophages at these sites. Time-course studies of carbonyl iron particle exposure demonstrated that iron induced a rapid macrophage response, but both particles and phagocytic macrophages were cleared from alveolar surfaces within 8 days after exposure. The Mt. St. Helens ash induced no macrophage accumulation at any time postexposure. We conclude that particles with a wide variety of physical characteristics are capable of activating complement and consequently attracting macrophages, both in vitro and in vivo. We suggest that complement activation is a mechanism through which pulmonary macrophages can detect inhaled particles on alveolar surfaces. JF - Experimental lung research AU - Warheit, D B AU - Overby, L H AU - George, G AU - Brody, A R AD - Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988 PY - 1988 DA - 1988 SP - 51 EP - 66 VL - 14 IS - 1 SN - 0190-2148, 0190-2148 KW - Asbestos, Serpentine KW - 0 KW - Calcium Compounds KW - Chemotactic Factors KW - Dust KW - Silicates KW - fiberglass KW - Asbestos, Crocidolite KW - 12001-28-4 KW - Asbestos KW - 1332-21-4 KW - Silicic Acid KW - 1343-98-2 KW - calcium silicate KW - S4255P4G5M KW - Index Medicus KW - Animals KW - Bronchial Provocation Tests KW - Asbestos -- pharmacology KW - Chemotaxis KW - Glass -- pharmacology KW - Silicic Acid -- metabolism KW - Rats KW - Silicic Acid -- pharmacology KW - Glass -- metabolism KW - Phagocytosis KW - Asbestos -- metabolism KW - Male KW - Macrophages -- cytology KW - Chemotactic Factors -- physiology KW - Pulmonary Alveoli -- cytology KW - Macrophages -- physiology KW - Complement Activation -- drug effects KW - Macrophages -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78120748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+lung+research&rft.atitle=Pulmonary+macrophages+are+attracted+to+inhaled+particles+through+complement+activation.&rft.au=Warheit%2C+D+B%3BOverby%2C+L+H%3BGeorge%2C+G%3BBrody%2C+A+R&rft.aulast=Warheit&rft.aufirst=D&rft.date=1988-01-01&rft.volume=14&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Experimental+lung+research&rft.issn=01902148&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-07 N1 - Date created - 1988-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Carcinogenesis in rats by cyclic N-nitrosamines containing sulphur. AN - 78117363; 3345967 AB - The effects of chronic exposure to three sulphur-containing heterocyclic N-nitrosamines were determined after repeated oral administration to female Fischer 344 rats. Nitrosothiazolidine did not significantly affect the survival of the rats or the incidence of tumours at a total dose of 3.5 mmol. Nitrosodithiazine, an analogue of nitrosothiazolidine which contains an extra sulphur atom inserted between the carbons of its CH2-CH2 moiety, produced only three tumours (two of the nasal mucosa) in a group of 20 rats at a total dose of 1.75 mmol/rat. Nitrosothialdine, the all-cis 2,4,6-trimethyl analogue of nitrosodithiazine, was a potent carcinogen that significantly shortened the lifespan and produced oesophageal tumours in 70% of treated rats as well as numerous tumours of the tongue and liver; this outcome was unexpected because alpha-methyl substitution in other heterocyclic nitrosamines usually reduces or eliminates tumorigenicity. The results extend the data base on the carcinogenic activity of molecules containing both divalent sulphur and the nitrosamino function. The lack of significant carcinogenicity of nitrosothiazolidine in this study suggests that its presence in the human food supply presents a relatively minor risk. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Lijinsky, W AU - Kovatch, R M AU - Keefer, L K AU - Saavedra, J E AU - Hansen, T J AU - Miller, A J AU - Fiddler, W AD - NCI-Frederick Cancer Research Facility, BRI-Basic Research Program, MD 21701. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 3 EP - 7 VL - 26 IS - 1 SN - 0278-6915, 0278-6915 KW - Heterocyclic Compounds KW - 0 KW - Nitrosamines KW - Nitroso Compounds KW - Thiazoles KW - N-nitrosodithiazine KW - 114282-83-6 KW - N-nitrosothiazolidine KW - 73870-33-4 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Chemistry KW - Chemical Phenomena KW - Female KW - Structure-Activity Relationship UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78117363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Carcinogenesis+in+rats+by+cyclic+N-nitrosamines+containing+sulphur.&rft.au=Lijinsky%2C+W%3BKovatch%2C+R+M%3BKeefer%2C+L+K%3BSaavedra%2C+J+E%3BHansen%2C+T+J%3BMiller%2C+A+J%3BFiddler%2C+W&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1988-01-01&rft.volume=26&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-13 N1 - Date created - 1988-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cocaine produces fine structural nuclear alterations in cultured neuroglioblastoma cells. AN - 78117146; 3342342 AB - NG 108-15 neuroglioblastoma cells were grown in culture medium containing either 10(-3), 10(-6) or 10(-9) M cocaine for 1-3 days. Some cultures were assessed for viability while others were processed for electron microscopy. Following 1-3 days of cocaine, no cytoplasmic alterations were observed compared to control; however, numerous dense bodies were present in some cells cultured with the highest doses. After 2 days of treatment with 10(-3) and 10(-6) M cocaine, nuclear invaginations were found filled with vesicles, and the nuclear membrane surrounding the vesicles was disrupted. Following 3 days of treatment with 10(-3) and 10(-6) M cocaine, patches of vesicles and tubules were also seen in the nucleus, but without surrounding membranes. The vesicles ranged in size from 0.05 to 0.8 micron. Cell counts revealed a significant slowing in the rate of cell division after two days of exposure to 10(-3) M cocaine. All concentrations of cocaine caused a significant decrease in cell viability by the third day of treatment. These results suggest that cocaine may interfere with cell replication and also may have a neurotoxic effect. JF - Brain research bulletin AU - Johnson, J E AU - Weissman, A D AD - Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, MD 21224. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 39 EP - 47 VL - 20 IS - 1 SN - 0361-9230, 0361-9230 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Microscopy, Electron KW - Glioma KW - Neuroblastoma KW - Cell Line KW - Cell Nucleus -- ultrastructure KW - Neurons -- drug effects KW - Cell Nucleus -- drug effects KW - Cocaine -- pharmacology KW - Neurons -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78117146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research+bulletin&rft.atitle=Cocaine+produces+fine+structural+nuclear+alterations+in+cultured+neuroglioblastoma+cells.&rft.au=Johnson%2C+J+E%3BWeissman%2C+A+D&rft.aulast=Johnson&rft.aufirst=J&rft.date=1988-01-01&rft.volume=20&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Brain+research+bulletin&rft.issn=03619230&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-05 N1 - Date created - 1988-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vivo generation of lymphokine activated killer cell activity by ABPP and interleukin-2 and their antitumor effects against immunogenic and nonimmunogenic tumors in murine tumor models. AN - 78116500; 3257900 AB - The capacity of the interferon inducer ABPP and recombinant interleukin-2 (IL-2) to generate lymphokine activated killer (LAK) cell activity in vivo was examined and compared to the cytolysis of fresh tumor cells by in vitro generated LAK cells. Various tumors differing in histology and immunogenicity were used in vitro and in vivo experiments. The i.p. administration of ABPP or IL-2 generated much higher levels of LAK cell activity in the peritoneal exudate than in the spleen. Administration of 2 injections of ABPP was as effective as a 3-day course of moderate doses of IL-2. Generation of LAK cell activity by IL-2 was dose dependent. ABPP had significant antitumor activity in vivo in both the i.p. tumor model and the pulmonary metastasis model when administered early (24-48 h after tumor inoculation), but was ineffective against established (day 3) tumor or advanced grossly visible i.p. (day 8) tumor. Treatment of established tumor with IL-2 and LAK cells was not more effective when ABPP was given concurrently. In contrast when ABPP preceded IL-2 and LAK treatment an additional antitumor effect was seen. Immunogenic tumors were more sensitive to treatment with ABPP than nonimmunogenic tumors. Only a marginal difference in lysability in vitro existed. The antitumor effects of ABPP in vivo may therefore be mediated by mechanisms other than cytolysis by activated killer cells alone. These data taken together suggest that ABPP and IL-2 induce discernable levels of LAK cell activity, but do not synergize when combined. JF - Cancer immunology, immunotherapy : CII AU - Eggermont, A M AU - Sugarbaker, P H AU - Marquet, R L AU - Jeekel, J AD - Surgery Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 23 EP - 30 VL - 26 IS - 1 SN - 0340-7004, 0340-7004 KW - Interleukin-2 KW - 0 KW - Cytosine KW - 8J337D1HZY KW - bropirimine KW - J57CTF25XJ KW - Index Medicus KW - Ascitic Fluid -- cytology KW - Animals KW - Spleen -- cytology KW - Ascitic Fluid -- immunology KW - Mice, Inbred C57BL KW - Spleen -- immunology KW - Mice KW - Drug Synergism KW - Female KW - Interleukin-2 -- pharmacology KW - Killer Cells, Natural -- transplantation KW - Neoplasms, Experimental -- immunology KW - Cytosine -- pharmacology KW - Neoplasms, Experimental -- therapy KW - Cytosine -- analogs & derivatives KW - Killer Cells, Natural -- immunology KW - Killer Cells, Natural -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78116500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.atitle=In+vivo+generation+of+lymphokine+activated+killer+cell+activity+by+ABPP+and+interleukin-2+and+their+antitumor+effects+against+immunogenic+and+nonimmunogenic+tumors+in+murine+tumor+models.&rft.au=Eggermont%2C+A+M%3BSugarbaker%2C+P+H%3BMarquet%2C+R+L%3BJeekel%2C+J&rft.aulast=Eggermont&rft.aufirst=A&rft.date=1988-01-01&rft.volume=26&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.issn=03407004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-15 N1 - Date created - 1988-04-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An endo-exonuclease activity of yeast that requires a functional RAD52 gene. AN - 78112664; 2830467 AB - Extracts of Rad+ and radiation-sensitive (rad) mutants of the yeast Saccharomyces cerevisiae were examined for total Mg2+-dependent alkaline deoxyribonuclease activity and the presence of a nuclease that crossreacts immunologically with an antiserum raised against an endo-exonuclease from Neurospora crassa, an enzyme exhibiting both deoxyribo- and ribonuclease activities. No significant differences were observed in total deoxyribonuclease activity between Rad+ and rad mutants. The antibody precipitable activity, however, was found to be 30%-40% of the total alkaline deoxyribonuclease activity in logarithmically growing Rad+ cells. Extracts of stationary phase cells were lacking in antibody precipitable activity. Using immunoblot methods, a 72 kDa crossreacting protein was identified from logarithmically growing cells that was absent from stationary phase cells. In all radiation-sensitive mutants examined, except rad52, at least 20% of total activity was precipitable. Extracts from logarithmically growing rad52 mutants, including a rad52::LEU2 insertion mutant, exhibited less than 10% of the Rad+ precipitable activity; however, some crossreacting material was detected. Although, the level of endo-exonuclease activity is influenced by the RAD52 gene, it is not the product of this gene. The total deoxyribonuclease and the antibody precipitable endo-exonuclease activities were also followed during meiosis. Unlike the Rad+ strain which had previously been shown to have increased levels of total and immunoprecipitable endo-exonuclease as cells underwent meiosis, the rad52 mutant exhibited no increases in either category of nuclease activity. Given the importance of the RAD52 gene in repair, recombination and mutagenesis, the endo-exonuclease may be a significant component of these processes. JF - Molecular & general genetics : MGG AU - Chow, T Y AU - Resnick, M A AD - Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 41 EP - 48 VL - 211 IS - 1 SN - 0026-8925, 0026-8925 KW - Fungal Proteins KW - 0 KW - Endonucleases KW - EC 3.1.- KW - Exonucleases KW - endoexonuclease KW - EC 3.1.4.- KW - Index Medicus KW - Genes, Fungal KW - Meiosis KW - Haploidy KW - Recombination, Genetic KW - Immunologic Techniques KW - Fungal Proteins -- genetics KW - Diploidy KW - DNA Repair KW - Exonucleases -- genetics KW - Saccharomyces cerevisiae -- enzymology KW - Endonucleases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78112664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+%26+general+genetics+%3A+MGG&rft.atitle=An+endo-exonuclease+activity+of+yeast+that+requires+a+functional+RAD52+gene.&rft.au=Chow%2C+T+Y%3BResnick%2C+M+A&rft.aulast=Chow&rft.aufirst=T&rft.date=1988-01-01&rft.volume=211&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Molecular+%26+general+genetics+%3A+MGG&rft.issn=00268925&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-05 N1 - Date created - 1988-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolic mapping of the oculomotor system in MPTP-induced parkinsonian monkeys. AN - 78111119; 3257855 AB - The quantitative autoradiographic 2-[14C]deoxyglucose method was used to map the distribution of alterations of local cerebral metabolic rate for glucose (lCMRGlc) in the oculomotor system of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-(MPTP)-induced parkinsonian monkeys. The lCMRGlc was decreased in the frontal eye fields and in the paralamellar mediodorsal thalamus in the parkinsonian monkeys as compared to normal controls. No changes in lCMRGlc were observed in other areas of the oculomotor system. L-Dopa therapy reversed the oculomotor symptoms in these monkeys, as well as the decrease of lCMRGlc in the frontal eye fields and the paralamellar mediodorsal thalamus. Because the frontal eye fields are known to be involved in the initiation of voluntary saccades, these findings suggest a functional anatomical basis for the oculomotor deficits in Parkinson's disease. JF - Annals of neurology AU - Ho, V W AU - Porrino, L J AU - Crane, A M AU - Burns, R S AU - Kopin, I J AU - Sokoloff, L AD - Howard Hughes Medical Institute, National Institutes of Health Research Scholar Program, Bethesda, MD. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 86 EP - 89 VL - 23 IS - 1 SN - 0364-5134, 0364-5134 KW - Pyridines KW - 0 KW - Levodopa KW - 46627O600J KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Eye Movements -- drug effects KW - Animals KW - Levodopa -- therapeutic use KW - Macaca mulatta KW - Male KW - Female KW - Parkinson Disease, Secondary -- physiopathology KW - Parkinson Disease, Secondary -- metabolism KW - Parkinson Disease, Secondary -- chemically induced KW - Oculomotor Muscles -- physiopathology KW - Glucose -- metabolism KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78111119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+neurology&rft.atitle=Metabolic+mapping+of+the+oculomotor+system+in+MPTP-induced+parkinsonian+monkeys.&rft.au=Ho%2C+V+W%3BPorrino%2C+L+J%3BCrane%2C+A+M%3BBurns%2C+R+S%3BKopin%2C+I+J%3BSokoloff%2C+L&rft.aulast=Ho&rft.aufirst=V&rft.date=1988-01-01&rft.volume=23&rft.issue=1&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Annals+of+neurology&rft.issn=03645134&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-25 N1 - Date created - 1988-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The genetic toxicity of human carcinogens and its implications. AN - 78106840; 3277048 AB - 23 chemicals and chemical combinations have been designated by the International Agency for Research on Cancer (IARC) as causally associated with cancer in humans. The literature was searched for reports of their activity in the Salmonella mutagenicity assay and for evidence of their ability to induce chromosome aberrations or micronuclei in the bone marrow of mice or rats. In addition, the chemical structures of these carcinogens were assessed for the presence of electrophilic substituents that might be associated with their mutagenicity and carcinogenicity. The purpose of this study was to determine which human carcinogens exhibit genetic toxicity in vitro and in vivo and to what extent they can be detected using these two widely employed short-term tests for genetic toxicity. The results of this study revealed 20 of the 23 carcinogens to be active in one or both short-term tests. Treosulphan, for which short-term test results are not available, is predicted to be active based on its structure. The remaining two agents, asbestos and conjugated estrogens, are not mutagenic to Salmonella; asbestos is not likely to induce cytogenetic effects in the bone marrow and the potential activity of conjugated estrogens in the bone marrow is difficult to anticipate. These findings show that genetic toxicity is characteristic of the majority of IARC Group 1 human carcinogens. If these chemicals are considered representative of human carcinogens, then two short-term tests may serve as an effective primary screen for chemicals that present a carcinogenic hazard to humans. JF - Mutation research AU - Shelby, M D AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 3 EP - 15 VL - 204 IS - 1 SN - 0027-5107, 0027-5107 KW - Carcinogens KW - 0 KW - Mutagens KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Structure-Activity Relationship KW - Mutagenicity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78106840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=The+genetic+toxicity+of+human+carcinogens+and+its+implications.&rft.au=Shelby%2C+M+D&rft.aulast=Shelby&rft.aufirst=M&rft.date=1988-01-01&rft.volume=204&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-21 N1 - Date created - 1988-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chordomas in Fischer 344 rats. AN - 78106317; 3344569 AB - Tissue sections and records of 56 rats with chordoma, identified in the National Toxicology Program's (NTP) data base of approximately 115,000 rats, were examined to determine morphological characteristics, incidence, and aspects of biological behavior. Chordomas occurred in aged rats, originated predominantly in lumbosacral vertebrae, were highly malignant, occurred three times more often in male versus female rats, and commonly produced bilateral posterior paresis, paralysis, and/or distention of the colon and rectum. JF - Veterinary pathology AU - Stefanski, S A AU - Elwell, M R AU - Mitsumori, K AU - Yoshitomi, K AU - Dittrich, K AU - Giles, H D AD - Chemical Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 42 EP - 47 VL - 25 IS - 1 SN - 0300-9858, 0300-9858 KW - Index Medicus KW - Rats KW - Animals KW - Microscopy, Electron KW - Immunohistochemistry KW - Sacrum KW - Male KW - Female KW - Lumbar Vertebrae KW - Rats, Inbred Strains KW - Chordoma -- pathology KW - Rats, Inbred F344 KW - Skull Neoplasms -- pathology KW - Chordoma -- ultrastructure KW - Spinal Neoplasms -- ultrastructure KW - Spinal Neoplasms -- pathology KW - Chordoma -- veterinary KW - Skull Neoplasms -- veterinary KW - Spinal Neoplasms -- veterinary KW - Skull Neoplasms -- ultrastructure KW - Rodent Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78106317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+pathology&rft.atitle=Chordomas+in+Fischer+344+rats.&rft.au=Stefanski%2C+S+A%3BElwell%2C+M+R%3BMitsumori%2C+K%3BYoshitomi%2C+K%3BDittrich%2C+K%3BGiles%2C+H+D&rft.aulast=Stefanski&rft.aufirst=S&rft.date=1988-01-01&rft.volume=25&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Veterinary+pathology&rft.issn=03009858&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-28 N1 - Date created - 1988-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phorbol esters induce multidrug resistance in human breast cancer cells. AN - 78105437; 3422442 AB - Mechanisms responsible for broad-based resistance to antitumor drugs derived from natural products (multidrug resistance) are incompletely understood. Agents known to reverse the multidrug-resistant phenotype (verapamil and trifluoperazine) can also inhibit the activity of protein kinase C. When we assayed human breast cancer cell lines for protein kinase C activity, we found that enzyme activity was 7-fold higher in the multidrug-resistant cancer cells compared with the control, sensitive parent cells. Exposure of drug-sensitive cells to the phorbol ester phorbol 12,13-dibutyrate [P(BtO)2] led to an increase in protein kinase C activity and induced a drug-resistance phenotype, whereas exposure of drug-resistant cells to P(BtO)2 further increased drug resistance. In sensitive cells, this increased resistance was accompanied by a 3.5-fold increased phosphorylation of a 20-kDa particulate protein and a 35-40% decreased intracellular accumulation of doxorubicin and vincristine. P(BtO)2 induced resistance to agents involved in the multidrug-resistant phenotype (doxorubicin and vincristine) but did not affect sensitivity to an unrelated alkylating agent (melphalan). The increased resistance was partially or fully reversible by the calcium channel blocker verapamil and by the calmodulin-antagonist trifluoperazine. These data suggest that stimulation of protein kinase C plays a role in the drug-transport changes in multidrug-resistant cells. This may occur through modulation of an efflux pump by protein phosphorylation. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Fine, R L AU - Patel, J AU - Chabner, B A AD - Clinical Pharmacology Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 582 EP - 586 VL - 85 IS - 2 SN - 0027-8424, 0027-8424 KW - Antineoplastic Agents KW - 0 KW - Carcinogens KW - Phorbol Esters KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Index Medicus KW - Protein Kinase C -- metabolism KW - Clone Cells KW - Phosphorylation KW - Humans KW - Drug Resistance KW - Female KW - Cell Line KW - Phorbol Esters -- pharmacology KW - Carcinogens -- pharmacology KW - Breast Neoplasms -- pathology KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78105437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Phorbol+esters+induce+multidrug+resistance+in+human+breast+cancer+cells.&rft.au=Fine%2C+R+L%3BPatel%2C+J%3BChabner%2C+B+A&rft.aulast=Fine&rft.aufirst=R&rft.date=1988-01-01&rft.volume=85&rft.issue=2&rft.spage=582&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-03 N1 - Date created - 1988-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1970 Aug 15;227(5259):680-5 [5432063] Proc Natl Acad Sci U S A. 1986 Dec;83(24):9328-32 [3540935] Biochim Biophys Acta. 1977 Apr 25;491(2):387-97 [857903] J Biol Chem. 1980 Sep 25;255(18):8378-80 [7410368] Biochem Biophys Res Commun. 1981 Mar 16;99(1):228-35 [7236262] J Biol Chem. 1982 Jul 25;257(14):8489-95 [7085679] Cancer Res. 1983 May;43(5):2267-72 [6831450] Cancer Res. 1983 Jun;43(6):2905-10 [6850602] Proc Natl Acad Sci U S A. 1983 Dec;80(23):7244-8 [6316349] Cancer Res. 1984 Jan;44(1):144-8 [6690032] Science. 1984 Jun 1;224(4652):994-6 [6372095] Cancer Res. 1985 Jun;45(6):2462-5 [3157445] J Biol Chem. 1985 Jul 5;260(13):8026-31 [2989273] Leuk Res. 1985;9(7):885-95 [2991669] Biochem Pharmacol. 1986 Feb 1;35(3):467-72 [3947382] Biochem Biophys Res Commun. 1986 Mar 13;135(2):397-402 [3457562] Science. 1986 Jul 18;233(4761):305-12 [3014651] Biochem Pharmacol. 1986 Aug 15;35(16):2683-6 [3461788] Leuk Res. 1986;10(9):1063-9 [3762216] J Biol Chem. 1986 Nov 25;261(33):15544-9 [3782078] Cancer Res. 1987 Jan 15;47(2):433-41 [3791232] Anal Biochem. 1976 May 7;72:248-54 [942051] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Relationship between in vitro tumor stem cell assay and in vivo antitumor activity using the P388 leukemia. AN - 78103391; 3339266 AB - The relationship between in vitro tumor stem cell sensitivity and in vivo antitumor efficacy using 13 active antineoplastic agents was examined by means of the intraperitoneal P388 mouse leukemia system. The doses, which produced a 50% increase in life span after one, five and nine days of treatment, were all significantly correlated with the in vitro concentration producing a 70% reduction in colony formation during a seven-day continuous drug exposure. The five-day correlation was the best, followed by nine days and one day. Correlations were not improved by corrections for either in vitro drug stability or toxicity (LD50). The highly significant correlations observed in this simple retrospective analysis provide a basis for the development of more sophisticated models for the prediction of in vivo results from in vitro data. JF - International journal of cell cloning AU - Marsh, J C AU - Shoemaker, R H AU - Salmon, S E AU - Kern, D H AU - Venditti, J M AD - Developmental Therapeutics Program, National Cancer Institute, Bethesda, Maryland. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 60 EP - 68 VL - 6 IS - 1 SN - 0737-1454, 0737-1454 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Injections, Intraperitoneal KW - Animals KW - Drug Administration Schedule KW - Humans KW - Disease Models, Animal KW - Mice KW - Leukemia P388 -- drug therapy KW - Antineoplastic Agents -- administration & dosage KW - Leukemia, Experimental -- drug therapy KW - Leukemia P388 -- pathology KW - Colony-Forming Units Assay KW - Tumor Stem Cell Assay KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78103391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cell+cloning&rft.atitle=Relationship+between+in+vitro+tumor+stem+cell+assay+and+in+vivo+antitumor+activity+using+the+P388+leukemia.&rft.au=Marsh%2C+J+C%3BShoemaker%2C+R+H%3BSalmon%2C+S+E%3BKern%2C+D+H%3BVenditti%2C+J+M&rft.aulast=Marsh&rft.aufirst=J&rft.date=1988-01-01&rft.volume=6&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cell+cloning&rft.issn=07371454&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-02 N1 - Date created - 1988-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Forskolin promotes the development of ethanol tolerance in 6-hydroxydopamine-treated mice. AN - 78099521; 3123833 AB - Partial depletion of brain norepinephrine by 6-hydroxydopamine prevents the development of functional tolerance to ethanol in mice. This blockade of tolerance development was overcome by daily intracerebroventricular injections of forskolin. These results suggest that interaction of norepinephrine with post-synaptic beta-adrenergic receptors, and activation of adenylate cyclase, is important for the development of ethanol tolerance. Interaction of norepinephrine with alpha 1-adrenergic receptors may be less crucial, since treatment with a phorbol ester activator of protein kinase C did not restore the development of tolerance in mice treated with 6-hydroxydopamine. The importance of the beta-adrenergic receptor-coupled adenylate cyclase system for development of ethanol tolerance, in addition to its previously-reported role in long-term potentiation, suggests that this system may influence neuroadaptive processes in general. JF - Life sciences AU - Szabó, G AU - Hoffman, P L AU - Tabakoff, B AD - Section on Receptor Mechanisms, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1988 PY - 1988 DA - 1988 SP - 615 EP - 621 VL - 42 IS - 6 SN - 0024-3205, 0024-3205 KW - Hydroxydopamines KW - 0 KW - Colforsin KW - 1F7A44V6OU KW - Ethanol KW - 3K9958V90M KW - Oxidopamine KW - 8HW4YBZ748 KW - Index Medicus KW - Drug Tolerance KW - Animals KW - Reference Values KW - Mice, Inbred C57BL KW - Mice KW - Male KW - Injections, Intraventricular KW - Colforsin -- pharmacology KW - Ethanol -- pharmacology KW - Cerebral Ventricles -- physiology KW - Hydroxydopamines -- toxicity KW - Colforsin -- administration & dosage KW - Cerebral Ventricles -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78099521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Forskolin+promotes+the+development+of+ethanol+tolerance+in+6-hydroxydopamine-treated+mice.&rft.au=Szab%C3%B3%2C+G%3BHoffman%2C+P+L%3BTabakoff%2C+B&rft.aulast=Szab%C3%B3&rft.aufirst=G&rft.date=1988-01-01&rft.volume=42&rft.issue=6&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-22 N1 - Date created - 1988-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cytogenetic and chemical detection of human exposure to polyhalogenated aromatic hydrocarbons. AN - 78095944; 3338440 AB - Peripheral lymphocytes from Taiwanese women (n = 35) exposed to polychlorinated aromatic hydrocarbons and from matched controls (n = 24) were assessed for the levels of sister chromatid exchanges (SCEs) after a 72-hour incubation of whole blood in the presence or absence of alpha-naphthoflavone (ANF) and for chromosome aberrations after 48 hours of incubation. Serum levels of polychlorinated biphenyl (PCB) congeners were measured for all individuals, and serum levels of several polychlorinated dibenzofurans (PCDFs) were measured for 12 exposed individuals by gas chromatography-mass spectometry. Blood concentrations of total PCBs in the exposed population averaged approximately 15 ppb, whereas mean PCDF values were 14 ppt. Major PCB congeners detected were 2,2' 4,4', 5,5'-hexa CB and 2,2'3,4,4',5-hexa CB. PCDFs detected were primarily 1,2,3,4,7,8,-hexachlorodibenzofuran (10.8 ppt) and 2,3,4,7,8-pentachlorodibenzofuran (2.7 ppt). Average SCE frequencies were 7.61 for controls and 7.30 for exposed individuals when assays were conducted in the absence of ANF, whereas respective values were 8.85 and 10.75 in the presence of ANF. Differences in the level of ANF-induced SCEs between the two populations were highly significant (P less than .001). Moreover, the ANF-induced SCEs were highly correlated with the serum concentrations of total PCBs and of several PCB congeners (P less than .001). Increases in ANF-induced SCEs appeared to be linear up to a PCB concentration of approximately 30 ppb. Chromosome aberration frequencies were similar in control and exposed populations. These studies demonstrate that in vivo exposure to PCBs and PCDFs result in an enhanced sensitivity of lymphocytes to the SCE-causing actions of ANF. JF - Environmental and molecular mutagenesis AU - Lundgren, K AU - Collman, G W AU - Wang-Wuu, S AU - Tiernan, T AU - Taylor, M AU - Thompson, C L AU - Lucier, G W AD - Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. Y1 - 1988 PY - 1988 DA - 1988 SP - 1 EP - 11 VL - 11 IS - 1 SN - 0893-6692, 0893-6692 KW - Benzoflavones KW - 0 KW - Polycyclic Compounds KW - alpha-naphthoflavone KW - 604-59-1 KW - Index Medicus KW - Humans KW - In Vitro Techniques KW - Environmental Exposure KW - Lymphocytes KW - Sister Chromatid Exchange KW - DNA Damage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78095944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Cytogenetic+and+chemical+detection+of+human+exposure+to+polyhalogenated+aromatic+hydrocarbons.&rft.au=Lundgren%2C+K%3BCollman%2C+G+W%3BWang-Wuu%2C+S%3BTiernan%2C+T%3BTaylor%2C+M%3BThompson%2C+C+L%3BLucier%2C+G+W&rft.aulast=Lundgren&rft.aufirst=K&rft.date=1988-01-01&rft.volume=11&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-26 N1 - Date created - 1988-02-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chirality and cytochrome P-450: a perspective. AN - 78094280; 3337733 JF - Biochemical pharmacology AU - Gelboin, H V AD - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988/01/01/ PY - 1988 DA - 1988 Jan 01 SP - 103 VL - 37 IS - 1 SN - 0006-2952, 0006-2952 KW - Pharmaceutical Preparations KW - 0 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Pharmaceutical Preparations -- metabolism KW - Humans KW - Molecular Conformation KW - Cytochrome P-450 Enzyme System -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78094280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Chirality+and+cytochrome+P-450%3A+a+perspective.&rft.au=Gelboin%2C+H+V&rft.aulast=Gelboin&rft.aufirst=H&rft.date=1988-01-01&rft.volume=37&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: conformationally restricted structural probes. AN - 78088229; 3122017 AB - A series of polychlorinated hydroxybiphenyls (PCBs) has been tested for their binding activity to soluble uterine estrogen receptor protein. Competitive binding analysis was performed on 0-40% ammonium sulfate-enriched uterine cytosol receptor preparations which improved the binding activity for the PCB compounds by a factor of 10-40, by decreasing the nonspecific binding. The binding activities have been correlated to molecular properties supported by molecular modeling studies which emphasize the importance of conformational restriction. The estrogen receptor bound 4-hydroxy-2',4',6'-trichlorobiphenyl (4H2',4',6'TCB) with the greatest affinity, with the concentration of unlabeled inhibitor yielding half-maximal specific binding relative to estradiol (C50) being approximately 42 compared to estradiol, C50 approximately 1.0. PCB compounds that demonstrated appreciable receptor-binding activity were also active in vivo in stimulating uterine weight increases, whereas weak binders were inactive. The 4H2',4',6'TCB compound represents a high degree of conformational restriction around the interring bond due to the presence of two ortho-chlorine atoms. The other PCBs in this series, which show lower receptor-binding activity, vary in position of chlorine substituents and can assume multiple low energy conformations as a result of less hindrance to rotation around the interring bond. JF - Molecular pharmacology AU - Korach, K S AU - Sarver, P AU - Chae, K AU - McLachlan, J A AU - McKinney, J D AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 120 EP - 126 VL - 33 IS - 1 SN - 0026-895X, 0026-895X KW - Receptors, Estrogen KW - 0 KW - Estradiol KW - 4TI98Z838E KW - Diethylstilbestrol KW - 731DCA35BT KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Animals KW - Uterus KW - Stereoisomerism KW - Diethylstilbestrol -- metabolism KW - Humans KW - Binding, Competitive KW - Cytosol KW - Mice KW - Molecular Conformation KW - Female KW - Structure-Activity Relationship KW - Estradiol -- metabolism KW - Polychlorinated Biphenyls -- metabolism KW - Receptors, Estrogen -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78088229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Estrogen+receptor-binding+activity+of+polychlorinated+hydroxybiphenyls%3A+conformationally+restricted+structural+probes.&rft.au=Korach%2C+K+S%3BSarver%2C+P%3BChae%2C+K%3BMcLachlan%2C+J+A%3BMcKinney%2C+J+D&rft.aulast=Korach&rft.aufirst=K&rft.date=1988-01-01&rft.volume=33&rft.issue=1&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Marked disparity in incidence of bacterial infections in patients with the acquired immunodeficiency syndrome receiving interleukin-2 or interferon-gamma. AN - 78082305; 3122616 AB - To compare the infectious complications that occurred during trials of immunomodulatory agents in patients with the acquired immunodeficiency syndrome (AIDS). A survey of two cohorts of patients with AIDS who participated in nonrandomized, unblinded, non-placebo-controlled investigations of the toxicity and efficacy of interleukin-2 and interferon-gamma. Clinical research unit in a tertiary care center. Consecutive samples of 52 patients given interleukin-2 and 22 patients given interferon-gamma. Selection criteria for referred patients included a diagnosis of AIDS, hemoglobin level of greater than 100 g/L (2.0 mg/dL), creatinine level of less than 176.8 mumol/L, bilirubin level of less than 25.65 mumol/L (1.5 mg/dL), the absence of active infection, and the absence of other drug therapy for 2 weeks before entry. Four patients given interleukin-2 failed to complete the study. Intravenous infusion of natural-product or recombinant human interleukin-2, 250 to 10,000,000 U/day for 23.4 +/- 1.5 (SE) days, or recombinant human interferon-gamma, 0.001 to 1.0 mg/m2.d for 17.7 +/- 4.8 days. Twenty nonopportunistic bacterial infections occurred in 17 of 52 patients given interleukin-2, whereas non occurred in 22 patients given interferon-gamma (P less than 0.05). Bacteremia accounted for 12 of the infections. Staphylococcus aureus and gram-negative bacilli accounted for 16 of the isolates. Opportunistic infections occurred in 6 patients during interleukin-2 infusion and in 1 patient during interferon-gamma infusion (P greater than 0.5). Clinical and immunologic variables and methods of management of intravenous catheters were similar in the two groups. A marked disparity in infection with nonopportunistic bacteria, but not with opportunistic organisms, occurred in patients with AIDS who were treated with interleukin-2 as compared with those who were treated with interferon-gamma. A high incidence of bacteremia and localized bacterial infection should be anticipated in patients with AIDS who receive interleukin-2. JF - Annals of internal medicine AU - Murphy, P M AU - Lane, H C AU - Gallin, J I AU - Fauci, A S AD - Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 36 EP - 41 VL - 108 IS - 1 SN - 0003-4819, 0003-4819 KW - Interleukin-2 KW - 0 KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Opportunistic Infections -- etiology KW - Immunity, Innate -- drug effects KW - Sepsis -- epidemiology KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Acquired Immunodeficiency Syndrome -- therapy KW - Acquired Immunodeficiency Syndrome -- complications KW - Interleukin-2 -- adverse effects KW - Bacterial Infections -- epidemiology KW - Interferon-gamma -- therapeutic use KW - Interleukin-2 -- therapeutic use KW - Bacterial Infections -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78082305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Marked+disparity+in+incidence+of+bacterial+infections+in+patients+with+the+acquired+immunodeficiency+syndrome+receiving+interleukin-2+or+interferon-gamma.&rft.au=Murphy%2C+P+M%3BLane%2C+H+C%3BGallin%2C+J+I%3BFauci%2C+A+S&rft.aulast=Murphy&rft.aufirst=P&rft.date=1988-01-01&rft.volume=108&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-18 N1 - Date created - 1988-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human serum sickness: a prospective analysis of 35 patients treated with equine anti-thymocyte globulin for bone marrow failure. AN - 78081641; 3257288 AB - We have prospectively evaluated the clinical and immunological features of serum sickness in 35 patients treated for bone marrow failure with anti-thymocyte globulin (ATG 15 mg/kg/day) and methylprednisolone (1 to 1.5 mg/kg/day). Twenty-one patients were treated for 10 days and 14 were treated for 28 days. Clinical evidence of serum sickness developed in 30 patients (86%) and included fever and malaise (100%), cutaneous eruptions (93%), arthralgias (67%), gastrointestinal complaints (67%), cephalgia (57%), blurring of vision (37%), arthritis, (30%) and lymphadenopathy (13%). Clinical serum sickness began on day 7 +/- 1 (X +/- S.E.M.) and lasted for 10 +/- 2 days in the 18 affected patients receiving the shorter course of ATG. In the 12 affected patients receiving the longer course of ATG, serum sickness began on day 9 +/- 1. The earliest manifestations of serum sickness were fever, malaise, and cutaneous eruptions. Cutaneous findings consisted of morbilliform eruptions (n = 19) and urticaria (n = 1) or a combination (n = 8) that lasted 10 to 14 days. Twenty-one patients (75%) developed a highly characteristic serpiginous band of erythema and purpura along the sides of the fingers, toes, palms and soles 12 to 48 hours before other symptoms of serum sickness. Biopsies of lesional skin during the course of serum sickness revealed immune deposits (IgM, IgE, IgA and C3) in dermal vasculature in 7 of 9 patients. Immunological changes that occurred during the course of serum sickness included increased serum levels of IgG, IgM, IgA, and IgE. Circulating immune complexes, as measured by the C1q-binding assay, increased from a mean value of 12% to 45% on day 13 +/- 1. Complement levels (C3, C4, and CH50) decreased 50 to 80% from their baseline levels on day 10 +/- 2. Acute phase reactants increased: erythrocyte sedimentation rate, C-reactive protein and beta-2 microglobulin. Abnormal urinalysis developed in 17 patients (57%) over the course of serum sickness and included proteinuria, hematuria and hemoglobinuria on day 10 +/- 3. Hematopoietic response occurred in 43%. All 5 patients who did not develop serum sickness recovered from bone marrow failure. Our data document the clinical and immunopathological findings in human serum sickness and suggest that the principles of antigen-antibody interaction, complement activation, and resultant inflammatory response as seen in the previous animal studies are directly applicable to studies of patients with serum sickness. JF - Medicine AU - Bielory, L AU - Gascon, P AU - Lawley, T J AU - Young, N S AU - Frank, M M AD - Clinical Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 40 EP - 57 VL - 67 IS - 1 SN - 0025-7974, 0025-7974 KW - Antigen-Antibody Complex KW - 0 KW - Antilymphocyte Serum KW - Immunoglobulins KW - Abridged Index Medicus KW - Index Medicus KW - Immunoglobulins -- analysis KW - Prospective Studies KW - Random Allocation KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Antigen-Antibody Complex -- analysis KW - Adolescent KW - Hematopoiesis KW - Male KW - Female KW - Serum Sickness -- immunology KW - Antilymphocyte Serum -- adverse effects KW - Anemia, Aplastic -- etiology KW - Bone Marrow -- physiopathology KW - Serum Sickness -- complications KW - T-Lymphocytes -- immunology KW - Serum Sickness -- physiopathology KW - Antilymphocyte Serum -- therapeutic use KW - Anemia, Aplastic -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78081641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicine&rft.atitle=Human+serum+sickness%3A+a+prospective+analysis+of+35+patients+treated+with+equine+anti-thymocyte+globulin+for+bone+marrow+failure.&rft.au=Bielory%2C+L%3BGascon%2C+P%3BLawley%2C+T+J%3BYoung%2C+N+S%3BFrank%2C+M+M&rft.aulast=Bielory&rft.aufirst=L&rft.date=1988-01-01&rft.volume=67&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Medicine&rft.issn=00257974&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - DNA recombinant and monoclonal antibody directed methods for determining cytochrome P-450 specificity. AN - 78079434; 3276324 JF - Biochemical pharmacology AU - Gelboin, H V AU - Park, S S AU - Battula, N AD - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988/01/01/ PY - 1988 DA - 1988 Jan 01 SP - 98 EP - 102 VL - 37 IS - 1 SN - 0006-2952, 0006-2952 KW - Antibodies, Monoclonal KW - 0 KW - DNA, Recombinant KW - Isoenzymes KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Phenotype KW - Vaccinia virus -- genetics KW - Animals KW - Stereoisomerism KW - Liver -- enzymology KW - Substrate Specificity KW - Immunologic Techniques KW - Species Specificity KW - Cytochrome P-450 Enzyme System -- analysis KW - Isoenzymes -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78079434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=DNA+recombinant+and+monoclonal+antibody+directed+methods+for+determining+cytochrome+P-450+specificity.&rft.au=Gelboin%2C+H+V%3BPark%2C+S+S%3BBattula%2C+N&rft.aulast=Gelboin&rft.aufirst=H&rft.date=1988-01-01&rft.volume=37&rft.issue=1&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Colchicine suppresses the release of fibroblast growth factors from alveolar macrophages in vitro. The basis of a possible therapeutic approach ot the fibrotic disorders. AN - 78077372; 3337460 AB - Fibrosis is the accumulation of fibroblasts and the connective tissue products secreted by these cells, usually subsequent to tissue injury. While fibrosis can be useful in preserving the general structural integrity of a tissue, it often alters cell-cell and cell-connective tissue interactions, which leads to loss of tissue function. On the basis of the concept that mononuclear phagocytes can direct the development of fibrosis through the release of specific mediators that stimulate fibroblast proliferation, we propose a therapeutic strategy to prevent fibrosis by preventing the release of these specific mediators. The present study demonstrated that colchicine, a widely used and well-tolerated drug, can block alveolar macrophage release of 2 mediators associated with the development of fibrosis in interstitial lung diseases, fibronectin, and the alveolar-macrophage-derived growth factor (AMDGF). Colchicine blocked the spontaneous release of fibronectin by alveolar macrophages obtained from patients with fibrotic lung disease by 23 +/- 4% after 24 h and by greater than 90% after 72 h. AMDGF release was blocked by 68 +/- 10% after 4 h (p less than 0.01, all comparisons). The effect of colchicine was not due to nonspecific toxicity since [14C]proline tracer studies demonstrated that macrophages treated with colchicine were capable of de novo protein synthesis and the secretion of several protein products, despite the fact that fibronectin and AMDGF release were suppressed. The effect of colchicine on the spontaneous release of both fibronectin and AMDGF could be observed at concentrations less than 10 ng/ml, levels that can be achieved in vivo.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American review of respiratory disease AU - Rennard, S I AU - Bitterman, P B AU - Ozaki, T AU - Rom, W N AU - Crystal, R G AD - Pulmonary Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 181 EP - 185 VL - 137 IS - 1 SN - 0003-0805, 0003-0805 KW - Fibronectins KW - 0 KW - Growth Substances KW - Peptides KW - alveolar macrophage growth factor KW - Colchicine KW - SML2Y3J35T KW - Abridged Index Medicus KW - Index Medicus KW - Pulmonary Alveoli -- pathology KW - Dose-Response Relationship, Drug KW - In Vitro Techniques KW - Fibronectins -- secretion KW - Male KW - Female KW - Macrophages -- secretion KW - Colchicine -- pharmacology KW - Growth Substances -- secretion KW - Pulmonary Fibrosis -- drug therapy KW - Colchicine -- therapeutic use KW - Colchicine -- pharmacokinetics KW - Pulmonary Fibrosis -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78077372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Colchicine+suppresses+the+release+of+fibroblast+growth+factors+from+alveolar+macrophages+in+vitro.+The+basis+of+a+possible+therapeutic+approach+ot+the+fibrotic+disorders.&rft.au=Rennard%2C+S+I%3BBitterman%2C+P+B%3BOzaki%2C+T%3BRom%2C+W+N%3BCrystal%2C+R+G&rft.aulast=Rennard&rft.aufirst=S&rft.date=1988-01-01&rft.volume=137&rft.issue=1&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Activators of protein kinase C act at a postreceptor site to amplify cyclic AMP production in rat pinealocytes. AN - 78040235; 2447232 AB - Activation of alpha 1-adrenoceptors appears to amplify beta-adrenergic stimulation of cyclic AMP (cAMP) accumulation in rat pinealocytes severalfold by a mechanism involving activation of a Ca2+-, phospholipid-dependent protein kinase (protein kinase C). The mechanism of action of protein kinase C was investigated in this report using intact cells. Activation of protein kinase C with 4 beta-phorbol 12-myristate 13-acetate (PMA; 10(-7) M) or the alpha 1-adrenergic agonist phenylephrine (PE; 10(-6) M) did not inhibit cAMP efflux in beta-adrenergically stimulated cells. The amplification of the beta-adrenergic cAMP response by these agents also occurred in the presence of isobutylmethylxanthine (10(-3) M) and Ro 20-1724 (10(-4) M), an observation suggesting that inhibition of cAMP phosphodiesterase activity is not the mechanism of action. Furthermore, although PMA (10(-7) M) caused a sixfold increase in the magnitude of the cAMP response to isoproterenol, it did not alter the EC50 of the response (1.7 X 10(-8) M), a result indicating that protein kinase C activation does not alter beta-adrenoceptor sensitivity. The cAMP response following cholera toxin pretreatment (60-120 min) was rapidly and markedly enhanced by alpha 1-adrenergic agonists (cirazoline greater than PE greater than methoxamine), by phorbol esters (PMA greater than 4 beta-phorbol 12,13,-dibutyrate much greater than 4 alpha-phorbol 12,13-didecanoate), and by synthetic diacylglycerols (1,2-dioctanoylglycerol greater than 1-oleoyl 2-acetylglycerol much greater than diolein). The cAMP response to forskolin (10(-5)-10(-3) M) was also increased by PE (3 X 10(-6) M) and PMA (10(-7) M).(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of neurochemistry AU - Sugden, D AU - Klein, D C AD - Section on Neuroendocrinology, National Institute of Child Health and Human Development, Bethesda, MD 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 149 EP - 155 VL - 50 IS - 1 SN - 0022-3042, 0022-3042 KW - Adrenergic alpha-Agonists KW - 0 KW - Phorbol Esters KW - Receptors, Adrenergic, alpha KW - Receptors, Adrenergic, beta KW - Colforsin KW - 1F7A44V6OU KW - Phenylephrine KW - 1WS297W6MV KW - 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone KW - 29925-17-5 KW - Cholera Toxin KW - 9012-63-9 KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinase C KW - EC 2.7.11.13 KW - 3',5'-Cyclic-AMP Phosphodiesterases KW - EC 3.1.4.17 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - 1-Methyl-3-isobutylxanthine KW - TBT296U68M KW - Index Medicus KW - Animals KW - Adrenergic alpha-Agonists -- pharmacology KW - Cholera Toxin -- pharmacology KW - 3',5'-Cyclic-AMP Phosphodiesterases -- antagonists & inhibitors KW - 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone -- pharmacology KW - 3',5'-Cyclic-AMP Phosphodiesterases -- metabolism KW - Rats, Inbred Strains KW - Rats KW - Phorbol Esters -- pharmacology KW - Colforsin -- pharmacology KW - Enzyme Activation -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - 1-Methyl-3-isobutylxanthine -- pharmacology KW - Female KW - Phenylephrine -- pharmacology KW - Protein Kinase C -- metabolism KW - Cyclic AMP -- biosynthesis KW - Pineal Gland -- metabolism KW - Receptors, Adrenergic, beta -- physiology KW - Pineal Gland -- drug effects KW - Receptors, Adrenergic, alpha -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78040235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Activators+of+protein+kinase+C+act+at+a+postreceptor+site+to+amplify+cyclic+AMP+production+in+rat+pinealocytes.&rft.au=Sugden%2C+D%3BKlein%2C+D+C&rft.aulast=Sugden&rft.aufirst=D&rft.date=1988-01-01&rft.volume=50&rft.issue=1&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-26 N1 - Date created - 1988-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Response of normal canine ureter to photodynamic therapy using a cylindrical fiber. AN - 78039251; 3336096 AB - Photodynamic therapy (PDT) was performed utilizing a cylindrical optical fiber to determine feasibility of distal ureteral treatment on 10 study and two control NIH foxhounds. The study animals were administered three mg./kg. dihematoporphyrin ether (Photofrin II) intravenously followed 48 hours later by open cystotomy. One ureter was irradiated with 42 joules of 630 nm. light delivered by a 660 micron diameter optical fiber modified for cylindrical light distribution. Intravenous urography was performed both at three days and six weeks post PDT. Hydroureteronephrosis was revealed in one treated ureter and one untreated ureter. Mild dilatation of the ureter was noted by urography in another treated ureter and in one ureter that did not undergo light irradiation; no distal obstruction was revealed in either case by proximal infusion of saline or by histopathology. Nine of the 10 treated ureters were found to have either no abnormal pathology or only minimal lymphocytic infiltration. In this study, the normal ureter was shown to tolerate photodynamic therapy at energy densities equivalent to those used to effect tumor regression and the feasibility of using a cylindrical optical fiber for treatment of ureteral malignancies was confirmed. JF - The Journal of urology AU - Manyak, M J AU - Matthews, D M AU - Smith, P D AU - Nochomovitz, L E AU - Glatstein, E AU - Russo, A AD - Radiation Oncology, Branche National Institutes of Health, Bethesda, MD 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 199 EP - 203 VL - 139 IS - 1 SN - 0022-5347, 0022-5347 KW - Abridged Index Medicus KW - Index Medicus KW - Carcinoma, Transitional Cell -- therapy KW - Animals KW - Hydronephrosis -- etiology KW - Ureteral Diseases -- etiology KW - Humans KW - Urography KW - Dogs KW - Urinary Bladder Neoplasms -- therapy KW - Ureteral Diseases -- diagnostic imaging KW - Models, Biological KW - Male KW - Hydronephrosis -- diagnostic imaging KW - Optical Fibers KW - Ureter -- pathology KW - Photochemotherapy -- adverse effects KW - Fiber Optic Technology -- instrumentation KW - Ureter -- diagnostic imaging KW - Photochemotherapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78039251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Response+of+normal+canine+ureter+to+photodynamic+therapy+using+a+cylindrical+fiber.&rft.au=Manyak%2C+M+J%3BMatthews%2C+D+M%3BSmith%2C+P+D%3BNochomovitz%2C+L+E%3BGlatstein%2C+E%3BRusso%2C+A&rft.aulast=Manyak&rft.aufirst=M&rft.date=1988-01-01&rft.volume=139&rft.issue=1&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-29 N1 - Date created - 1988-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Thrombolysis in Myocardial Infarction (TIMI) Trial--phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase. AN - 78035289; 3121710 AB - Two hundred ninety patients with acute myocardial infarction were treated according to random assignment with an intravenous infusion of either 80 mg of recombinant tissue plasminogen activator (rt-PA) over 3 h or 1.5 million units of streptokinase over 1 h. Patients received an intravenous bolus of heparin (5,000 U [USP]) before pretreatment coronary angiography and a continuous infusion (1,000 U/h) starting 3 h later. The frequency of major and minor hemorrhagic events (33% rt-PA, 31% streptokinase) and associated transfusions (22% rt-PA, 20% streptokinase) were comparable in both groups. More than 70% of bleeding episodes in each group occurred at catheterization or vascular puncture sites. Precipitable fibrinogen levels, measured in plasma samples collected in the presence of a protease inhibitor (aprotinin), declined in rt-PA and streptokinase groups by averages of 26 and 57% at 3 h and by 33 and 58% at 5 h, respectively (rt-PA versus streptokinase, p less than 0.001). At 5 h the plasma plasminogen declined by 57% (rt-PA) and 82% (streptokinase) (p less than 0.001); plasma fibrin(ogen) degradation products were higher in streptokinase-treated patients (244 +/- 12 micrograms/ml, mean +/- SE) than in rt-PA-treated patients (97 +/- 9 micrograms/ml, p less than 0.001). At 27 h, plasma fibrinogen and plasminogen levels were lower and fibrin(ogen) degradation products higher than pretreatment levels in both groups. The frequency of hemorrhagic events was higher in patients with greater changes in plasma factors at 5 h; within treatment groups the levels of fibrin(ogen) degradation products correlated with bleeding complications (p less than 0.005). Thus, in the doses administered, rt-PA induces systemic fibrinogenolysis that is substantially less intense than that induced by streptokinase. The high frequency of bleeding encountered is related to the protocol used, including vigorous anticoagulation, arterial punctures and thrombolytic therapy. These findings emphasize the need for avoidance of invasive procedures and for meticulous care in the selection and management of patients subjected to thrombolytic therapy. JF - Journal of the American College of Cardiology AU - Rao, A K AU - Pratt, C AU - Berke, A AU - Jaffe, A AU - Ockene, I AU - Schreiber, T L AU - Bell, W R AU - Knatterud, G AU - Robertson, T L AU - Terrin, M L AD - Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 1 EP - 11 VL - 11 IS - 1 SN - 0735-1097, 0735-1097 KW - Recombinant Proteins KW - 0 KW - Fibrinogen KW - 9001-32-5 KW - Streptokinase KW - EC 3.4.- KW - Tissue Plasminogen Activator KW - EC 3.4.21.68 KW - Abridged Index Medicus KW - Index Medicus KW - Random Allocation KW - Humans KW - Clinical Trials as Topic KW - Thrombocytopenia -- chemically induced KW - Fibrinogen -- analysis KW - Tissue Plasminogen Activator -- therapeutic use KW - Streptokinase -- adverse effects KW - Hemorrhage -- chemically induced KW - Tissue Plasminogen Activator -- adverse effects KW - Streptokinase -- therapeutic use KW - Recombinant Proteins -- adverse effects KW - Fibrinolysis KW - Recombinant Proteins -- therapeutic use KW - Myocardial Infarction -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78035289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Thrombolysis+in+Myocardial+Infarction+%28TIMI%29+Trial--phase+I%3A+hemorrhagic+manifestations+and+changes+in+plasma+fibrinogen+and+the+fibrinolytic+system+in+patients+treated+with+recombinant+tissue+plasminogen+activator+and+streptokinase.&rft.au=Rao%2C+A+K%3BPratt%2C+C%3BBerke%2C+A%3BJaffe%2C+A%3BOckene%2C+I%3BSchreiber%2C+T+L%3BBell%2C+W+R%3BKnatterud%2C+G%3BRobertson%2C+T+L%3BTerrin%2C+M+L&rft.aulast=Rao&rft.aufirst=A&rft.date=1988-01-01&rft.volume=11&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-02 N1 - Date created - 1988-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modulation of tissue and epidermal transglutaminases in mouse epidermal cells after treatment with 12-O-tetradecanoylphorbol-13-acetate and/or retinoic acid in vivo and in culture. AN - 78035128; 2891434 AB - Retinoic acid (RA) induces tissue transglutaminase (TGASE) and inhibits terminal differentiation induced either by calcium ion or by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in primary mouse epidermal cells in culture. The relevance of these effects on cultured cells to the antipromoting action of RA was investigated in female BALB/c and CD-1 mice in vivo. Tissue TGASE was distinguished from epidermal TGASE on the basis of different thermolability at pH 9 or elution from the anion exchanger Mono Q. After topical application of 3 to 5 micrograms (10 to 17 nmol) of RA to the shaved back skin, the specific activity of tissue TGASE increased up to 30-fold primarily in the basal cell fraction of Percoll-separated epidermal cells. Enzyme activity returned to basal levels by 7 days. Treatment with TPA (10 micrograms or 17 nmol/mouse) induced an increase in epidermal TGASE which reached a maximum at 12 h after application, primarily in suprabasal cells. RA applied 1 h before TPA caused no reduction of TPA-induced epidermal TGASE, but the increase in tissue TGASE due to RA was markedly inhibited by TPA. The effects of TPA and RA on TGASE activities in primary epidermal cells in culture were similar to those in vivo except that RA reduced the induction of epidermal TGASE by TPA. In culture the induction of epidermal TGASE by TPA was independent of Ca2+ concentration in the medium above 0.03 mM, but cornified envelope formation was markedly enhanced by Ca2+ above the level required for maintaining a basal cell population (0.03 to 0.05 mM). The TPA-induced formation of cornified envelope in the presence of elevated Ca2+ was completely inhibited by RA if cells were pretreated with RA for 24 h. Our results are consistent with RA causing a reprogramming of epidermal cells that alters their response to differentiation stimuli. JF - Cancer research AU - Lichti, U AU - Yuspa, S H AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988/01/01/ PY - 1988 DA - 1988 Jan 01 SP - 74 EP - 81 VL - 48 IS - 1 SN - 0008-5472, 0008-5472 KW - Tretinoin KW - 5688UTC01R KW - Transglutaminases KW - EC 2.3.2.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Enzyme Induction KW - Mice KW - Calcium -- pharmacology KW - Mice, Inbred BALB C KW - Cell Differentiation -- drug effects KW - Time Factors KW - Tretinoin -- pharmacology KW - Skin -- enzymology KW - Skin -- drug effects KW - Transglutaminases -- biosynthesis KW - Tetradecanoylphorbol Acetate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78035128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Modulation+of+tissue+and+epidermal+transglutaminases+in+mouse+epidermal+cells+after+treatment+with+12-O-tetradecanoylphorbol-13-acetate+and%2For+retinoic+acid+in+vivo+and+in+culture.&rft.au=Lichti%2C+U%3BYuspa%2C+S+H&rft.aulast=Lichti&rft.aufirst=U&rft.date=1988-01-01&rft.volume=48&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-08 N1 - Date created - 1988-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Synergistic antiproliferative effects of glucocorticoids and interferon-alpha on some lymphoid cell lines. AN - 78034744; 3335582 AB - The Daudi B lymphoblastoid cell line was previously demonstrated to be highly sensitive to the antiproliferative effect of recombinant interferon-alpha A (rIFN-alpha A). In the present study, glucocorticoid hormones were shown to act synergistically with rIFN-alpha A to further increase the sensitivity of Daudi cells to rIFN-alpha A. At 10(-6) M, dexamethasone, prednisolone, or hydrocortisone alone had little effect on Daudi cell growth, but they greatly potentiated the antiproliferative activity of rIFN-alpha A. The synergy between rIFN-alpha A and glucocorticoids on Daudi cells was not related to the inhibitory effects of glucocorticoids on prostaglandin or leukotriene synthesis, since no synergy was observed between rIFN-alpha A and indomethacin or nordihydroguaiaretic acid. Glucocorticoids and rIFN-alpha A also had appreciable synergistic antiproliferative effects on two out of five other IFN-sensitive lymphoid cell lines. When Raji B lymphoblastoid cells, which were quite resistant to the antiproliferative effect of rIFN-alpha A, were treated with the combination of glucocorticoids and rIFN-alpha A, no significant synergistic effects were observed. The synergistic antiproliferative effects of glucocorticoids and rIFN-alpha A observed with some IFN-sensitive lymphoid cell lines in this in vitro study may have clinical relevance in the treatment of certain lymphoid malignancies that are sensitive to rIFN-alpha A therapy. JF - Journal of cellular physiology AU - Elliott, K R AU - Princler, G L AU - Urba, W J AU - Faltynek, C R AD - Laboratory of Biochemical Physiology, National Cancer Institute, Frederick Cancer Research Facility, Maryland 21701. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 85 EP - 92 VL - 134 IS - 1 SN - 0021-9541, 0021-9541 KW - Glucocorticoids KW - 0 KW - Interferon Type I KW - Recombinant Proteins KW - Masoprocol KW - 7BO8G1BYQU KW - Thymidine KW - VC2W18DGKR KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Thymidine -- metabolism KW - Cell Division -- drug effects KW - Drug Synergism KW - Lymphoma, Non-Hodgkin -- pathology KW - Cell Line KW - Masoprocol -- pharmacology KW - Indomethacin -- pharmacology KW - Lymphoid Tissue -- cytology KW - Interferon Type I -- pharmacology KW - Glucocorticoids -- pharmacology KW - Lymphoid Tissue -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78034744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=Synergistic+antiproliferative+effects+of+glucocorticoids+and+interferon-alpha+on+some+lymphoid+cell+lines.&rft.au=Elliott%2C+K+R%3BPrincler%2C+G+L%3BUrba%2C+W+J%3BFaltynek%2C+C+R&rft.aulast=Elliott&rft.aufirst=K&rft.date=1988-01-01&rft.volume=134&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=00219541&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts. AN - 78034153; 3121168 AB - We have developed four murine epidermal cell lines which form squamous papillomas when grafted to athymic nude mice in a reconstituted skin. Two of the lines, SP-1 and BP-4, were derived from pools of papillomas produced on SENCAR and BALB/c mouse skin, respectively, by initiation with 7,12-dimethylbenz(a)anthracene and promotion with 12-O-tetradecanoylphorbol-13-acetate. Line 308 was derived from BALB/c mouse skin initiated in vivo with 7,12-dimethylbenz(a)anthracene, culture of the epidermal cells, and selection of cells resistant to Ca2+-induced terminal differentiation. Line LC14 was derived from untreated, cultured newborn BALB/c mouse primary epidermal cells which spontaneously developed resistance to Ca2+-induced terminal differentiation. Each line has an activated rasHa gene with a mutation within codon 61. Cells from all four lines, in contrast to normal primary epidermal cells, survive in medium with Ca2+ levels greater than 0.1 mM. Clonal growth studies in culture showed a unique growth pattern for each of the four lines in medium with 1.4 mM and 0.05 mM Ca2+, with or without 12-O-tetradecanoylphorbol-13-acetate. Early passage cells of these lines should provide a valuable resource for detecting genes or genetic alterations which complement an activated ras gene to cause malignant conversion and for studying the biology of tumor promotion. JF - Cancer research AU - Strickland, J E AU - Greenhalgh, D A AU - Koceva-Chyla, A AU - Hennings, H AU - Restrepo, C AU - Balaschak, M AU - Yuspa, S H AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988/01/01/ PY - 1988 DA - 1988 Jan 01 SP - 165 EP - 169 VL - 48 IS - 1 SN - 0008-5472, 0008-5472 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Neoplasm Transplantation KW - Animals KW - Alleles KW - Transfection KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Mice, Nude KW - Mice KW - Calcium -- pharmacology KW - Mice, Inbred BALB C KW - Cell Line KW - Oncogenes KW - Papilloma -- pathology KW - Papilloma -- etiology KW - Skin Neoplasms -- etiology KW - Skin Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78034153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Development+of+murine+epidermal+cell+lines+which+contain+an+activated+rasHa+oncogene+and+form+papillomas+in+skin+grafts+on+athymic+nude+mouse+hosts.&rft.au=Strickland%2C+J+E%3BGreenhalgh%2C+D+A%3BKoceva-Chyla%2C+A%3BHennings%2C+H%3BRestrepo%2C+C%3BBalaschak%2C+M%3BYuspa%2C+S+H&rft.aulast=Strickland&rft.aufirst=J&rft.date=1988-01-01&rft.volume=48&rft.issue=1&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-08 N1 - Date created - 1988-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preliminary results of a randomized study of adjuvant radiation therapy in resectable adult retroperitoneal soft tissue sarcomas. AN - 78032912; 3275748 AB - Between January 1980 and September 1985, 35 adult patients with resectable retroperitoneal soft tissue sarcomas were entered on a randomized trial comparing two forms of adjuvant radiation therapy. Fifteen patients received the experimental therapy consisting of intraoperative radiotherapy (IORT) to 20 Gy using high-energy electrons followed by low-dose (35 to 40 Gy) postoperative external beam irradiation. Twenty patients received standard therapy consisting of high-dose (50 to 55 Gy) postoperative external beam irradiation. With a minimum follow-up of 15 months, there is no significant difference in the actuarial disease-free survival (DFS) and overall survival (OS) comparing the two groups (median DFS, 34 months; median OS, 38 months). At 5 years follow-up, approximately 40% of patients are alive and 20% of patients remain disease-free. Although there is a trend towards an improvement in in-field local control in the experimental arm, the predominant pattern of failure in both groups was locoregional within the retroperitoneum and/or peritoneal cavity. Acute and late radiation enteritis were significantly reduced in the experimental group. However, four experimental patients developed late (greater than 6 months following treatment) peripheral neuropathy believed related to the use of IORT; all four recovered. We conclude that there is no difference in the therapeutic effectiveness of the combination of IORT and low-dose external beam radiation compared with conventional high-dose radiation as adjuvant treatment in retroperitoneal sarcomas, although the former appears to be less toxic. Newer combined modality treatment strategies are discussed to improve the prognosis in these patients. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Kinsella, T J AU - Sindelar, W F AU - Lack, E AU - Glatstein, E AU - Rosenberg, S A AD - Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 18 EP - 25 VL - 6 IS - 1 SN - 0732-183X, 0732-183X KW - Index Medicus KW - Postoperative Care KW - Random Allocation KW - Combined Modality Therapy KW - Radiotherapy Dosage KW - Intraoperative Care KW - Humans KW - Adult KW - Clinical Trials as Topic KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Retroperitoneal Neoplasms -- radiotherapy KW - Sarcoma -- radiotherapy KW - Retroperitoneal Neoplasms -- mortality KW - Soft Tissue Neoplasms -- radiotherapy KW - Soft Tissue Neoplasms -- mortality KW - Sarcoma -- mortality KW - Retroperitoneal Neoplasms -- therapy KW - Soft Tissue Neoplasms -- therapy KW - Sarcoma -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78032912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Preliminary+results+of+a+randomized+study+of+adjuvant+radiation+therapy+in+resectable+adult+retroperitoneal+soft+tissue+sarcomas.&rft.au=Kinsella%2C+T+J%3BSindelar%2C+W+F%3BLack%2C+E%3BGlatstein%2C+E%3BRosenberg%2C+S+A&rft.aulast=Kinsella&rft.aufirst=T&rft.date=1988-01-01&rft.volume=6&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of antibody dose on the imaging and biodistribution of indium-111 9.2.27 anti-melanoma monoclonal antibody. AN - 78032318; 3335926 AB - Eleven patients with metastatic melanoma underwent serial gamma camera imaging and biodistribution measurements after i.v. injection of escalating doses of [111In]9.2.27, an antimelanoma murine monoclonal antibody. Patients received a fixed dose of 1 mg of [111In]9.2.27, with no additional 9.2.27 (five patients), or co-infused with 49 mg (five patients) or 99 mg (one patient) of unlabeled, unconjugated 9.2.27. Higher doses resulted in prolonged blood-pool retention, less uptake in spleen and bone marrow, and appeared to have a positive effect in improving tumor imaging. A dose of 1 mg of 9.2.27 permitted detection of tumors in two of five patients and two of ten lesions, while with greater than or equal to 50 mg, tumors were detected in all patients and in 24 of 32 lesions. Human gamma globulin injected prior to administration of [111In]9.2.27 failed to block the prominent liver, spleen, and bone marrow uptake. No toxicity was observed. These results indicate the feasibility of imaging metastatic melanoma with [111In]9.2.27 and suggest that antibody dose may be a critical determinant of biodistribution and tumor uptake. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Carrasquillo, J A AU - Abrams, P G AU - Schroff, R W AU - Reynolds, J C AU - Woodhouse, C S AU - Morgan, A C AU - Keenan, A M AU - Foon, K A AU - Perentesis, P AU - Marshall, S AD - Nuclear Medicine Department, National Institutes of Health, Bethesda, Maryland 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 39 EP - 47 VL - 29 IS - 1 SN - 0161-5505, 0161-5505 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Neoplasm KW - Indium Radioisotopes KW - Index Medicus KW - Humans KW - Neoplasm Metastasis KW - Middle Aged KW - Tissue Distribution KW - Male KW - Female KW - Radionuclide Imaging KW - Melanoma -- diagnostic imaging KW - Antibodies, Neoplasm -- administration & dosage KW - Melanoma -- immunology KW - Antibodies, Monoclonal -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78032318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Effect+of+antibody+dose+on+the+imaging+and+biodistribution+of+indium-111+9.2.27+anti-melanoma+monoclonal+antibody.&rft.au=Carrasquillo%2C+J+A%3BAbrams%2C+P+G%3BSchroff%2C+R+W%3BReynolds%2C+J+C%3BWoodhouse%2C+C+S%3BMorgan%2C+A+C%3BKeenan%2C+A+M%3BFoon%2C+K+A%3BPerentesis%2C+P%3BMarshall%2C+S&rft.aulast=Carrasquillo&rft.aufirst=J&rft.date=1988-01-01&rft.volume=29&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-08 N1 - Date created - 1988-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Benzodiazepine enhancement of gamma-aminobutyric acid-mediated chloride ion flux in rat brain synaptoneurosomes. AN - 78029399; 3335847 AB - Benzodiazepine agonists such as Ro 11-6896 [B10(+)], diazepam, clonazepam, and flurazepam were found to enhance muscimol-stimulated 36Cl- uptake into rat cerebral cortical synaptoneurosomes. The rank order of potentiation was B10(+) greater than diazepam greater than clonazepam greater than flurazepam. These benzodiazepines had no effect on 36Cl-uptake in the absence of muscimol. Further, the inactive enantiomer, Ro 11-6893 [B10(-)], and the peripheral benzodiazepine receptor ligand Ro 5-4864 did not potentiate muscimol-stimulated 36Cl- uptake at concentrations up to 10 microM. In contrast, the benzodiazepine receptor inverse agonists ethyl-beta-carboline-3-carboxylate and 6,7-dimethoxy-4-ethyl-beta- carboline-3-carboxylic acid methyl ester inhibited muscimol stimulated 36Cl- uptake. Benzodiazepines and beta-carbolines altered the apparent K0.5 of muscimol-stimulated 36Cl- uptake, without affecting the Vmax. The effects of both benzodiazepine receptor agonists and inverse agonists were reversed by the benzodiazepine antagonists Ro 15-1788 and CGS-8216. These data further confirm that central benzodiazepine receptors modulate the capacity of gamma-aminobutyric acid receptor agonists to enhance chloride transport and provide a biochemical technique for studying benzodiazepine receptor function in vitro. JF - Journal of neurochemistry AU - Morrow, A L AU - Paul, S M AD - Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, MD 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 302 EP - 306 VL - 50 IS - 1 SN - 0022-3042, 0022-3042 KW - Benzodiazepinones KW - 0 KW - Carbolines KW - Chlorides KW - Benzodiazepines KW - 12794-10-4 KW - methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate KW - 1309288N1J KW - Muscimol KW - 2763-96-4 KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Clonazepam KW - 5PE9FDE8GB KW - Ro 11-6893 KW - 66921-17-3 KW - beta-carboline-3-carboxylic acid ethyl ester KW - 74214-62-3 KW - Flurazepam KW - IHP475989U KW - Diazepam KW - Q3JTX2Q7TU KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Flurazepam -- pharmacology KW - Animals KW - Diazepam -- pharmacology KW - Carbolines -- pharmacology KW - Drug Synergism KW - Benzodiazepinones -- pharmacology KW - Muscimol -- pharmacology KW - Male KW - Clonazepam -- pharmacology KW - Synaptosomes -- drug effects KW - gamma-Aminobutyric Acid -- pharmacology KW - Brain -- drug effects KW - Chlorides -- metabolism KW - Brain -- metabolism KW - Benzodiazepines -- pharmacology KW - Synaptosomes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78029399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Benzodiazepine+enhancement+of+gamma-aminobutyric+acid-mediated+chloride+ion+flux+in+rat+brain+synaptoneurosomes.&rft.au=Morrow%2C+A+L%3BPaul%2C+S+M&rft.aulast=Morrow&rft.aufirst=A&rft.date=1988-01-01&rft.volume=50&rft.issue=1&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-26 N1 - Date created - 1988-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Flow cytometric DNA ploidy in colorectal adenomas and family history of colorectal cancer. AN - 78029299; 3334937 AB - Flow cytometric DNA ploidy of colorectal adenomas resected from 34 patients and the corresponding patient family history in first-degree relatives were evaluated. The samples with at least two separate G0-G1 peaks were defined as DNA aneuploid. The correlation between DNA ploidy and family history was evaluated using two-by-two contingency tables. This correlation was highly statistically significant: seven of nine patients (78%) with positive family histories, and five of 25 (20%) with negative family history had adenomas with DNA aneuploid stemlines (P = 0.0068). The overall DNA aneuploidy incidence was 12 in 34 cases (35.2%). The combined information of DNA aneuploidy and positive family history of colorectal cancer in patients with colorectal adenomas may help to better understand the process of colon carcinogenesis and to identify patients who have a higher risk for developing a malignancy. JF - Cancer AU - Sciallero, S AU - Bruno, S AU - Di Vinci, A AU - Geido, E AU - Aste, H AU - Giaretti, W AD - Endoscopic Service, National Cancer Institute (IST), Genoa, Italy. Y1 - 1988/01/01/ PY - 1988 DA - 1988 Jan 01 SP - 114 EP - 120 VL - 61 IS - 1 SN - 0008-543X, 0008-543X KW - DNA, Neoplasm KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Colorectal Neoplasms, Hereditary Nonpolyposis -- analysis KW - Aged KW - Middle Aged KW - Ploidies KW - Male KW - Female KW - Rectal Neoplasms -- genetics KW - Colonic Neoplasms -- genetics KW - Colonic Neoplasms -- analysis KW - Flow Cytometry KW - DNA, Neoplasm -- analysis KW - Rectal Neoplasms -- analysis KW - Adenoma -- genetics KW - Adenoma -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78029299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Flow+cytometric+DNA+ploidy+in+colorectal+adenomas+and+family+history+of+colorectal+cancer.&rft.au=Sciallero%2C+S%3BBruno%2C+S%3BDi+Vinci%2C+A%3BGeido%2C+E%3BAste%2C+H%3BGiaretti%2C+W&rft.aulast=Sciallero&rft.aufirst=S&rft.date=1988-01-01&rft.volume=61&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-16 N1 - Date created - 1988-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity. AN - 78028741; 3257102 AB - Site-specific mutagenesis was used to introduce amino acid substitutions at the asparagine codons of four conserved potential N-linked glycosylation sites within the gp120 envelope protein of human immunodeficiency virus (HIV). One of these alterations resulted in the production of noninfectious virus particles. The amino acid substitution did not interfere with the synthesis, processing, and stability of the env gene polypeptides gp120 and gp41 or the binding of gp120 to its cellular receptor, the CD4 (T4) molecule. Vaccinia virus recombinants containing wild-type or mutant HIV env genes readily induced syncytia in CD4+ HeLa cells. These results suggest that alterations involving the second conserved domain of the HIV gp120 may interfere with an essential early step in the virus replication cycle other than binding to the CD4 receptor. In long-term cocultures of a T4+ lymphocyte cell line and colon carcinoma cells producing the mutant virus, revertant infectious virions were detected. Molecular characterization of two revertant proviral clones revealed the presence of the original mutation as well as a compensatory amino acid change in another region of HIV gp120. JF - Journal of virology AU - Willey, R L AU - Smith, D H AU - Lasky, L A AU - Theodore, T S AU - Earl, P L AU - Moss, B AU - Capon, D J AU - Martin, M A AD - Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 139 EP - 147 VL - 62 IS - 1 SN - 0022-538X, 0022-538X KW - Antigens, Differentiation, T-Lymphocyte KW - 0 KW - Receptors, Virus KW - Viral Envelope Proteins KW - Index Medicus KW - AIDS/HIV KW - Virus Replication KW - Receptors, Virus -- physiology KW - Cell Fusion KW - T-Lymphocytes -- microbiology KW - DNA Mutational Analysis KW - Antigens, Differentiation, T-Lymphocyte -- physiology KW - Morphogenesis KW - Virion -- physiology KW - Viral Envelope Proteins -- physiology KW - Genes, Viral KW - HIV -- genetics KW - HIV -- pathogenicity KW - Viral Envelope Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78028741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=In+vitro+mutagenesis+identifies+a+region+within+the+envelope+gene+of+the+human+immunodeficiency+virus+that+is+critical+for+infectivity.&rft.au=Willey%2C+R+L%3BSmith%2C+D+H%3BLasky%2C+L+A%3BTheodore%2C+T+S%3BEarl%2C+P+L%3BMoss%2C+B%3BCapon%2C+D+J%3BMartin%2C+M+A&rft.aulast=Willey&rft.aufirst=R&rft.date=1988-01-01&rft.volume=62&rft.issue=1&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-21 N1 - Date created - 1988-01-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 1967 Jun 14;26(2):365-9 [4291934] J Virol. 1987 Aug;61(8):2639-41 [2439707] J Virol. 1973 Dec;12(6):1457-65 [4357516] Virology. 1974 Feb;57(2):475-90 [4361457] Science. 1977 Apr 8;196(4286):175-7 [322278] Science. 1977 Apr 8;196(4286):180-2 [322279] Cell. 1987 Sep 11;50(6):975-85 [2441877] Rev Infect Dis. 1980 Jan-Feb;2(1):40-61 [6994202] J Virol. 1981 Apr;38(1):239-48 [6165830] Science. 1983 May 20;220(4599):868-71 [6189183] J Virol. 1984 Mar;49(3):857-64 [6321770] Virology. 1984 Feb;133(1):65-76 [6199893] Gene. 1977 May;1(3-4):255-80 [338419] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] Proc Natl Acad Sci U S A. 1979 Mar;76(3):1373-6 [286319] Science. 1984 May 4;224(4648):500-3 [6200936] Science. 1984 Aug 24;225(4664):840-2 [6206563] DNA. 1984 Aug;3(4):339-43 [6489095] Proc Natl Acad Sci U S A. 1984 Nov;81(22):7161-5 [6438633] DNA. 1984 Dec;3(6):479-88 [6096101] Science. 1985 Feb 1;227(4686):484-92 [2578227] Cell. 1985 Jan;40(1):9-17 [2981635] Proc Natl Acad Sci U S A. 1985 Jul;82(13):4539-43 [2989831] J Immunol. 1985 Nov;135(5):3151-62 [2995487] Annu Rev Immunol. 1985;3:477-500 [2415141] Science. 1986 Jan 24;231(4736):382-5 [3001934] Anal Biochem. 1986 Apr;154(1):353-60 [3010776] Cell. 1986 Jun 6;45(5):637-48 [2423250] Cell. 1986 Jul 4;46(1):63-74 [2424612] Proc Natl Acad Sci U S A. 1986 Jul;83(14):5038-42 [3014529] J Virol. 1986 Aug;59(2):284-91 [3016298] Nature. 1986 Jul 31-Aug 6;322(6078):470-4 [3016552] Mol Cell Biol. 1985 Dec;5(12):3403-9 [3939316] J Immunol. 1986 Nov 1;137(9):2937-44 [2428879] Cell. 1986 Nov 7;47(3):333-48 [3094962] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8380-4 [3490666] J Virol. 1987 Jan;61(1):209-13 [3640832] Cell. 1987 Feb 27;48(4):691-701 [3643816] Cell. 1987 Jun 5;49(5):659-68 [3107838] Nature. 1970 Aug 15;227(5259):680-5 [5432063] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Combined effects of chemotherapy and interleukin 2 in the therapy of mice with advanced pulmonary tumors. AN - 78026287; 3257159 AB - We have evaluated the effects of chemotherapeutic agents on the toxicity and antitumor benefit of therapy of established murine tumors by high-dose interleukin 2 (IL-2). Cyclophosphamide (Cy), doxorubicin, and bischloroethylnitrosourea were given to normal mice prior to IL-2 administration to test the effects of these agents on IL-2-induced toxicity. Cy at doses of 100 mg/kg and 150 mg/kg completely protected mice from a 100% lethal dose of IL-2, and doses of 50 mg/kg and 150 mg/kg allowed the administration of a median of 4.5 and 10.0 more doses of IL-2, respectively, before death from IL-2 toxicity occurred. Doxorubicin at 8 mg/kg and bischloroethylnitrosourea at 20 mg/kg did not impact on toxicity in IL-2-treated mice. In mice bearing pulmonary metastases of the weakly immunogenic MCA-105 sarcoma, IL-2 increased median survival time from 33 (no IL-2) to greater than 60 days for all doses of IL-2 tested when combined with a single injection of Cy at 75 mg/kg (P less than 0.002). Increasing doses of either Cy or IL-2 produced increasing benefits on survival which were always greater than either treatment alone. These effects of Cy and IL-2 were also seen in mice bearing the nonimmunogenic MCA-101 sarcoma and a murine adenocarcinoma (MCA-38). Doxorubicin and bischloroethylnitrosourea did not consistently enhance the effects of IL-2 treatment. Cy appears to reduce the yield of in vivo generated lymphokine-activated killer cells, but these lymphokine-activated killer cells are still lytic for fresh tumor targets in vitro. Thus, the mechanism of this synergy does not appear to involve stimulation of lymphokine-activated killer cell activity, but may in part involve reduction of tumor burden by the chemotherapeutic agent, an increase in susceptibility of tumor to cellular immune lysis, and/or a decrease in suppressor cell activity mediated by the chemotherapy. JF - Cancer research AU - Papa, M Z AU - Yang, J C AU - Vetto, J T AU - Shiloni, E AU - Eisenthal, A AU - Rosenberg, S A AD - Surgery Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988/01/01/ PY - 1988 DA - 1988 Jan 01 SP - 122 EP - 129 VL - 48 IS - 1 SN - 0008-5472, 0008-5472 KW - Interleukin-2 KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Animals KW - Lymphocytes -- immunology KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Mice KW - Killer Cells, Natural -- immunology KW - Killer Cells, Natural -- drug effects KW - Interleukin-2 -- administration & dosage KW - Lung Neoplasms -- drug therapy KW - Interleukin-2 -- toxicity KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78026287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Combined+effects+of+chemotherapy+and+interleukin+2+in+the+therapy+of+mice+with+advanced+pulmonary+tumors.&rft.au=Papa%2C+M+Z%3BYang%2C+J+C%3BVetto%2C+J+T%3BShiloni%2C+E%3BEisenthal%2C+A%3BRosenberg%2C+S+A&rft.aulast=Papa&rft.aufirst=M&rft.date=1988-01-01&rft.volume=48&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-08 N1 - Date created - 1988-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Tamoxifen inhibits estrogen-induced hepatic injury in hamsters. AN - 78024597; 3335202 AB - Estrogens have an unusual toxic effect on the liver of two hamster species, the Armenian and the Chinese hamster. The hepatotoxicity was detectable clinically by hyperbilirubinemia and confirmed histologically by the presence of hepatic degenerative-regenerative changes. Administration of tamoxifen with estrogen [either ethynyl estradiol or diethylstilbestrol (DES)] completely abrogated the hepatotoxic effects, suggesting that estrogen receptor (ER) was necessary for estrogen to damage liver. In Armenian hamsters, estrogens decreased hepatic synthesis of female protein (FP); tamoxifen also abolished this DES effect and resulted in a net increase in serum FP levels. DES administration produced higher serum bilirubin levels and lower serum FP levels in females than in males. Paradoxically, tamoxifen blocked these DES effects more effectively and efficiently in females than in males. Estrogens did not injure uteri of Armenian and Chinese hamsters and were nontoxic to livers of other hamsters species, such as Syrian and Turkish. This model provides another perspective of the acute cellular derangement that can be effected by estrogen-ER complex and may indicate a yet unknown mode of ER action. JF - Endocrinology AU - Coe, J E AU - Ross, M J AD - Department of Health and Human Services, National Institutes of Health, Hamilton, Montana 59840. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 137 EP - 144 VL - 122 IS - 1 SN - 0013-7227, 0013-7227 KW - Tamoxifen KW - 094ZI81Y45 KW - Diethylstilbestrol KW - 731DCA35BT KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Sex Factors KW - Cricetulus KW - Time Factors KW - Species Specificity KW - Male KW - Female KW - Cricetinae KW - Tamoxifen -- pharmacology KW - Liver -- pathology KW - Liver -- drug effects KW - Diethylstilbestrol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78024597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Tamoxifen+inhibits+estrogen-induced+hepatic+injury+in+hamsters.&rft.au=Coe%2C+J+E%3BRoss%2C+M+J&rft.aulast=Coe&rft.aufirst=J&rft.date=1988-01-01&rft.volume=122&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-03 N1 - Date created - 1988-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Site-selective cAMP analogs at micromolar concentrations induce growth arrest and differentiation of acute promyelocytic, chronic myelocytic, and acute lymphocytic human leukemia cell lines. AN - 78024267; 2825845 AB - Cyclic AMP (cAMP)-dependent protein kinase may play a role in the functional and morphological differentiation of leukemic cells. In this study, we showed that the cAMP analogs, potent activators of protein kinase recently shown to be selective for either site 1 or site 2 cAMP binding sites of protein kinase, demonstrate potent growth inhibition of acute promyelocytic, chronic myelocytic, and acute lymphocytic leukemic cell lines with no sign of toxicity. The growth inhibition accompanied monocytic differentiation in HL-60 cells and a loss of nuclear terminal deoxynucleotidyl transferase activity in Molt-4 leukemic cells. The growth inhibition also paralleled a decrease in c-myc protein and RI cAMP receptor protein. Thus, cAMP analogs selective for either site 1 or site 2 of the protein kinase appear to restore a coupling of proliferation and maturation in leukemic cells. JF - Blood AU - Tortora, G AU - Tagliaferri, P AU - Clair, T AU - Colamonici, O AU - Neckers, L M AU - Robins, R K AU - Cho-Chung, Y S AD - Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 230 EP - 233 VL - 71 IS - 1 SN - 0006-4971, 0006-4971 KW - Neoplasm Proteins KW - 0 KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinases KW - EC 2.7.- KW - Abridged Index Medicus KW - Index Medicus KW - Protein Kinases -- metabolism KW - Humans KW - Enzyme Activation -- drug effects KW - Cell Division -- drug effects KW - Cell Differentiation -- drug effects KW - Neoplasm Proteins -- metabolism KW - Tumor Cells, Cultured -- drug effects KW - Cyclic AMP -- pharmacology KW - Leukemia, Lymphoid -- pathology KW - Cyclic AMP -- analogs & derivatives KW - Leukemia, Myeloid, Acute -- pathology KW - Leukemia, Myeloid -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78024267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Site-selective+cAMP+analogs+at+micromolar+concentrations+induce+growth+arrest+and+differentiation+of+acute+promyelocytic%2C+chronic+myelocytic%2C+and+acute+lymphocytic+human+leukemia+cell+lines.&rft.au=Tortora%2C+G%3BTagliaferri%2C+P%3BClair%2C+T%3BColamonici%2C+O%3BNeckers%2C+L+M%3BRobins%2C+R+K%3BCho-Chung%2C+Y+S&rft.aulast=Tortora&rft.aufirst=G&rft.date=1988-01-01&rft.volume=71&rft.issue=1&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Experimental chemotherapy-induced skin necrosis in swine. Mechanistic studies of anthracycline antibiotic toxicity and protection with a radical dimer compound. AN - 78019913; 3121673 AB - The reactivity of antitumor anthracycline and mitomycin C antibiotics with the oxomorpholinyl radical dimers, bi(3,5,5-trimethyl-2-oxomorpholin-3-yl) (TM3) and bi(3,5-dimethyl-5-hydroxymethyl-2-oxomorpholin-3-yl) (DHM3), was studied in vitro. The oxomorpholinyl radical reduced daunorubicin to a quinone methide intermediate that reacted with solvent to form 7-deoxydaunorubicinone. The solvolysis reaction followed first order kinetics, and the reactivity rate constants (k2) measured for seven anthracycline analogues ranged from 2 X 10(-2) s-1 to 8.0 X 10(-4) s-1. The chemical reactivity of each anthracycline quinone methide correlated with the total skin toxicity caused by the respective parent anthracycline following injection into swine skin. Microscopic examination of experimental lesions in swine skin resemble those observed in humans after inadvertant chemotherapy extravasation. Hydrocortisone sodium succinate was not effective for the treatment of doxorubicin-induced skin necrosis, whereas DHM3 was effective for the treatment of skin necrosis caused by all seven anthracyclines and by the quinone containing antibiotic, mitomycin C. JF - The Journal of clinical investigation AU - Averbuch, S D AU - Boldt, M AU - Gaudiano, G AU - Stern, J B AU - Koch, T H AU - Bachur, N R AD - Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 142 EP - 148 VL - 81 IS - 1 SN - 0021-9738, 0021-9738 KW - Antibiotics, Antineoplastic KW - 0 KW - Free Radicals KW - Mitomycins KW - Morpholines KW - Mitomycin KW - 50SG953SK6 KW - Doxorubicin KW - 80168379AG KW - bis(3,5-dimethyl-5-hydroxymethyl-2-oxomorpholin-3-yl) KW - 99634-12-5 KW - Abridged Index Medicus KW - Index Medicus KW - Swine KW - Animals KW - Necrosis KW - Drug Interactions KW - Doxorubicin -- toxicity KW - Mitomycins -- pharmacology KW - Swine, Miniature KW - Female KW - Skin Diseases -- drug therapy KW - Morpholines -- therapeutic use KW - Morpholines -- pharmacology KW - Skin Diseases -- pathology KW - Skin Diseases -- chemically induced KW - Antibiotics, Antineoplastic -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78019913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Experimental+chemotherapy-induced+skin+necrosis+in+swine.+Mechanistic+studies+of+anthracycline+antibiotic+toxicity+and+protection+with+a+radical+dimer+compound.&rft.au=Averbuch%2C+S+D%3BBoldt%2C+M%3BGaudiano%2C+G%3BStern%2C+J+B%3BKoch%2C+T+H%3BBachur%2C+N+R&rft.aulast=Averbuch&rft.aufirst=S&rft.date=1988-01-01&rft.volume=81&rft.issue=1&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-09 N1 - Date created - 1988-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer. 1971 Oct;28(4):837-43 [4329505] J Invest Dermatol. 1972 Mar;58(3):114-23 [4622425] Cancer. 1976 Sep;38(3):1087-94 [953958] Transplantation. 1976 Dec;22(6):559-67 [137560] Science. 1977 Aug 5;197(4303):527-32 [877572] Am J Nurs. 1979 Jan;79(1):94-6 [252885] Inflammation. 1980 Jun;4(2):233-47 [6446523] Cancer Treat Rev. 1980 Mar;7(1):17-27 [7397706] Cancer Chemother Pharmacol. 1980;5(1):17-20 [7460191] J Biol Chem. 1981 May 25;256(10):4747-56 [6262301] Cancer Res. 1982 Mar;42(3):1078-81 [6277472] Biochem Pharmacol. 1982 Feb 15;31(4):575-81 [6279110] Cancer. 1982 May 1;49(9):1796-9 [7042076] Cancer Res. 1982 Sep;42(9):3574-82 [6809311] Cancer. 1983 Mar 15;51(6):1080-2 [6401597] J Hand Surg Am. 1983 Jan;8(1):32-8 [6827049] Cancer Chemother Pharmacol. 1983;11(2):91-3 [6627601] Cancer Treat Rep. 1984 Jul-Aug;68(7-8):939-45 [6378380] Plast Reconstr Surg. 1985 Mar;75(3):397-405 [3883378] Biochemistry. 1985 Jul 2;24(14):3562-71 [3862429] Cancer Res. 1985 Dec;45(12 Pt 1):6200-4 [4063971] J Clin Oncol. 1986 Jan;4(1):88-94 [3941333] Environ Health Perspect. 1985 Dec;64:4-18 [3913602] Cancer Treat Rep. 1986 Apr;70(4):503-7 [3009011] J Hand Surg Am. 1986 May;11(3):388-96 [3711613] Mol Pharmacol. 1986 Jun;29(6):622-8 [3086708] J Invest Dermatol. 1964 Jul;42:11-21 [14209446] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ram seminal vesicle microsome-catalyzed activation of benzidine and related compounds: dissociation of mutagenesis from peroxidase-catalyzed formation of DNA-reactive material. AN - 78019898; 3335047 AB - Ram seminal vesicle (RSV) microsomal preparations activate benzidine and other arylamines to mutagenic species in a modified Ames assay. We have examined the mechanism of this activation process in more detail. The mutagenic effect was neither arachidonic acid-dependent nor indomethacin inhibitable. The mutagenic species was stable for at least 30 min in experiments in which addition of bacteria was delayed. Acetylbenzidine was a much more potent mutagen than benzidine in this system. Substitution of the acetylase-deficient tester strain TA98/1,8-DNP6 for strain TA98 markedly reduced the mutagenicity of acetylbenzidine and completely eliminated the mutagenicity of benzidine. Benzidine analogues 3,3'-dimethoxybenzidine (o-dianisidine), o-tolidine and 3,3',-5,5'-tetramethylbenzidine were not mutagenic in the RSV activation system. RSV-dependent activation of all radiolabeled congeners examined resulted in covalent binding to calfthymus DNA. The rank order of binding was: 3,3'-dichlorobenzidine greater than benzidine greater than o-dianisidine greater than acetylbenzidine greater than tetramethylbenzidine. This binding required active enzyme and arachidonic acid or hydrogen peroxide. The reactive species was short-lived: delayed addition of DNA reduced the level of binding nearly to zero. Binding was inhibitable by indomethacin, but this inhibition was incomplete in the cases of dichlorobenzidine and acetylbenizidine. We conclude that the extracellular generation of peroxidase-catalyzed oxidation products does not explain the RSV microsome-dependent mutagenicity observed with these compounds. JF - Carcinogenesis AU - Petry, T W AU - Eling, T E AU - Chiu, A L AU - Josephy, P D AD - Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 51 EP - 57 VL - 9 IS - 1 SN - 0143-3334, 0143-3334 KW - Benzidines KW - 0 KW - Phenols KW - Phenol KW - 339NCG44TV KW - DNA KW - 9007-49-2 KW - Peroxidases KW - EC 1.11.1.- KW - Glutathione KW - GAN16C9B8O KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Animals KW - Mutagenicity Tests KW - Biotransformation KW - Sheep KW - Phenols -- metabolism KW - Ascorbic Acid -- pharmacology KW - Mutation KW - Glutathione -- pharmacology KW - Male KW - Peroxidases -- metabolism KW - Indomethacin -- pharmacology KW - Benzidines -- metabolism KW - Seminal Vesicles -- metabolism KW - Microsomes -- metabolism KW - DNA -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78019898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Ram+seminal+vesicle+microsome-catalyzed+activation+of+benzidine+and+related+compounds%3A+dissociation+of+mutagenesis+from+peroxidase-catalyzed+formation+of+DNA-reactive+material.&rft.au=Petry%2C+T+W%3BEling%2C+T+E%3BChiu%2C+A+L%3BJosephy%2C+P+D&rft.aulast=Petry&rft.aufirst=T&rft.date=1988-01-01&rft.volume=9&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-18 N1 - Date created - 1988-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 4-chloro-3-hydroxyanthranilate inhibits brain 3-hydroxyanthranate oxidase. AN - 733575790; 19651098 AB - Quinolinic acid is synthesized from 3-hydroxyanthranilic acid via 3-hydroxyanthranilic acid oxidase. In liver, 4-chloro-3-hydroxyanthranilic acid inhibits 3-hydroxyanthranilic acid oxidase. To determine whether 4-chloro-3-hydroxyanthranilic acid also inhibits 3-hydroxyanthranilic acid oxidase in brain, 3-hydroxyanthranilic acid was injected into the cisterna magna of rats either with or without 4-chloro-3 hydroxyanthranilic acid. 3-Hydroxyanthranilic acid increased quinolinic acid concentrations throughout the brain. 4-Chloro-3-hydroxyanthranilic acid attenuated increases in brain quinolinic acid. These observations indicate that 4-chloro-3-hydroxyanthranilic acid inhibits 3-hydroxyanthranilic acid oxidase in brain. Quinolinic acid is a well established systemic metabolite of l-tryptophan which has been shown to be present in brain (Wolfensberger et al., 1983; Heyes and Markey, 1988a). QUIN has proved to be a convulsant (Lapin, 1982), neurotoxin (Schwarcz et al., 1983) and agonist of N-methyl-D-aspartate receptors (Perkins and Stone, 1983) when injected directly into the central nervous system of experimental animals. Therefore increased concentrations of QUIN in brain may have neoropathologic consequences. l-Tryptophan is converted to QUIN via the kynurenine pathway. The precursor of QUIN, 2-amino-3-carboxymuconic semialdehyde is synthesized from 3-hydroxyanthranilic acid (3-HAA) by the action of 3-hydroxyanthranilic acid oxidase (3-HAA/OX) in liver and brain (Foster et al., 1986; Okuno et al., 1987). QUIN is then formed from 2-amino-3-carboxymuconic semialdehyde by a spontaneous, non-enzymatic reaction. In liver, 3-HAA/OX is inhibited by 4-chloro-3-hydroxyantranilic acid (CL-HAA; Parli et al., 1980). In the present study, rats were given an intracisternal injection of 3-HAA and the resultant increases in regional brain QUIN concentrations quantified by gas chromatography/mass spectrometry (Heyes and Markey, 1988a,b). To determine whether CL-HAA inhibit 3-hydroxyanthranilic acid oxidase in brain, CL-HAA was co-administered with 3-HAA to see whether increases in QUIN were attenuated. JF - Neurochemistry international AU - Heyes, M P AU - Hutto, B AU - Markey, S P AD - Laboratory of Neurophysiology, Building 10, Room 3D40 National Institute of Mental Health, Bethesda, MD 20892 USA. Y1 - 1988 PY - 1988 DA - 1988 SP - 405 EP - 408 VL - 13 IS - 3 SN - 0197-0186, 0197-0186 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733575790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=4-chloro-3-hydroxyanthranilate+inhibits+brain+3-hydroxyanthranate+oxidase.&rft.au=Heyes%2C+M+P%3BHutto%2C+B%3BMarkey%2C+S+P&rft.aulast=Heyes&rft.aufirst=M&rft.date=1988-01-01&rft.volume=13&rft.issue=3&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=01970186&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-14 N1 - Date created - 2009-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Structural Pattern Theory of Modern Society AN - 61019687; 90V1785 AB - A general trend in modern society is identified as the transformation of a strategy of unitary economic growth into a strategy of overall social development that includes attention to the relations among society, economy, & scientific technology. The historical materialist perspective of Karl Marx has reached a new stage in history, because, unlike in Marx's time, it need not emphasize criticism of the idealist conception of history. A summary of the structural pattern theory of modern society is offered in which society is seen -- as Marx conceived it -- as a unity of humans & nature. Three main stratifications form its overall structure: the ecological system between humans & nature; the major subsystems of economy, science, culture, etc; & the nucleus of productive force, the individual. 2 Figures. Modified AA JF - Revue Internationale de Sociologie/International Review of Sociology (nouvelle serie/new series) AU - Shuwei, Song AD - Chinese Academy Social Sciences, 5 Jianguomen Nei Da Jie 5 Hao Beijing Y1 - 1988///0, PY - 1988 DA - 0, 1988 SP - 7 EP - 23 IS - 3 SN - 0390-6701, 0390-6701 KW - modern society, structural pattern theory KW - Marxist Sociology KW - Social Development KW - Social Structure KW - Modern Society KW - article KW - 0715: social change and economic development; social change & economic development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61019687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Revue+Internationale+de+Sociologie%2FInternational+Review+of+Sociology+%28nouvelle+serie%2Fnew+series%29&rft.atitle=The+Structural+Pattern+Theory+of+Modern+Society&rft.au=Shuwei%2C+Song&rft.aulast=Shuwei&rft.aufirst=Song&rft.date=1988-01-01&rft.volume=&rft.issue=3&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Revue+Internationale+de+Sociologie%2FInternational+Review+of+Sociology+%28nouvelle+serie%2Fnew+series%29&rft.issn=03906701&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - RISOD6 N1 - SubjectsTermNotLitGenreText - Modern Society; Social Development; Marxist Sociology; Social Structure ER - TY - JOUR T1 - A report of geological observations on northern segment (Baotou to Mondula) of the geoscience transect from Xiangshui, Jiangsu, to Mandula, Nei Monggol AN - 50780771; 1989-062032 JF - Dizhen Dizhi = Seismology and Geology AU - Ma, Xingyuan AU - Wang, Ji AU - Li, Shuangqing AU - Liu, De-jian AU - Bai, Yunhong AU - Zhou, Chun-ping AU - Huang, Guo-hua Y1 - 1988 PY - 1988 DA - 1988 SP - 45 EP - 50 PB - Dizhen Chubanshe, Beijing VL - 10 IS - 4 SN - 0253-4967, 0253-4967 KW - Inner Mongolia China KW - Far East KW - upper Precambrian KW - Precambrian KW - Mandala KW - Chartai Aulacogen KW - Paleozoic KW - Northern China KW - Jiangsu China KW - Variscan Orogeny KW - basement KW - aulacogens KW - Proterozoic KW - Bayan Obo Geocline KW - Mesoproterozoic KW - Caledonian Orogeny KW - structural geology KW - folds KW - tectonics KW - Asia KW - China KW - 16:Structural geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50780771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dizhen+Dizhi+%3D+Seismology+and+Geology&rft.atitle=A+report+of+geological+observations+on+northern+segment+%28Baotou+to+Mondula%29+of+the+geoscience+transect+from+Xiangshui%2C+Jiangsu%2C+to+Mandula%2C+Nei+Monggol&rft.au=Ma%2C+Xingyuan%3BWang%2C+Ji%3BLi%2C+Shuangqing%3BLiu%2C+De-jian%3BBai%2C+Yunhong%3BZhou%2C+Chun-ping%3BHuang%2C+Guo-hua&rft.aulast=Ma&rft.aufirst=Xingyuan&rft.date=1988-01-01&rft.volume=10&rft.issue=4&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Dizhen+Dizhi+%3D+Seismology+and+Geology&rft.issn=02534967&rft_id=info:doi/ LA - Chinese DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 1989-01-01 N1 - Number of references - 5 N1 - Document feature - illus. incl. sects., geol. sketch map N1 - Last updated - 2014-03-14 N1 - SubjectsTermNotLitGenreText - Asia; aulacogens; basement; Bayan Obo Geocline; Caledonian Orogeny; Chartai Aulacogen; China; Far East; folds; Inner Mongolia China; Jiangsu China; Mandala; Mesoproterozoic; Northern China; Paleozoic; Precambrian; Proterozoic; structural geology; tectonics; upper Precambrian; Variscan Orogeny ER - TY - JOUR T1 - The Silurian biostratigraphy of Inner Mongolia AN - 50682048; 1990-042401 JF - Diceng Gushengwu Lunwen Ji = Professional Papers of Stratigraphy and Palaeontology AU - Li, Wenguo Y1 - 1988 PY - 1988 DA - 1988 SP - 180 EP - 192 PB - Ti Chih Chu Pan She, Beijing VL - 21 SN - 0254-1351, 0254-1351 KW - stratigraphy KW - Inner Mongolia China KW - Far East KW - biostratigraphy KW - Barendel Formation KW - Paleozoic KW - Silurian KW - marine environment KW - Brachiopoda KW - Invertebrata KW - Graptolithina KW - Asia KW - China KW - 12:Stratigraphy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50682048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diceng+Gushengwu+Lunwen+Ji+%3D+Professional+Papers+of+Stratigraphy+and+Palaeontology&rft.atitle=The+Silurian+biostratigraphy+of+Inner+Mongolia&rft.au=Li%2C+Wenguo&rft.aulast=Li&rft.aufirst=Wenguo&rft.date=1988-01-01&rft.volume=21&rft.issue=&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Diceng+Gushengwu+Lunwen+Ji+%3D+Professional+Papers+of+Stratigraphy+and+Palaeontology&rft.issn=02541351&rft_id=info:doi/ LA - Chinese DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1990-01-01 N1 - Number of references - 9 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Asia; Barendel Formation; biostratigraphy; Brachiopoda; China; Far East; Graptolithina; Inner Mongolia China; Invertebrata; marine environment; Paleozoic; Silurian; stratigraphy ER - TY - JOUR T1 - Amorphous Soluble Cyclodextrins: Pharmaceutical and Therapeutic Uses AN - 21203560; 11612576 AB - Amorphous water soluble derivatives of cyclodextrins are potent, nontoxic solubilizers of drugs and lipids. Their use as excipients which enable effective oral administration of sex hormones is described. Furthermore, these com pounds were used intravenously as an active drug to assist an organism in unloading a toxic lipophile. JF - Journal of Bioactive and Compatible Polymers AU - Pitha, Josef AD - National Institutes of Health, National Institute on Aging Gerontology Research Center, Macromolecular Chemistry Section Baltimore, MD 21224, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 157 EP - 163 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 3 IS - 2 SN - 0883-9115, 0883-9115 KW - Biotechnology and Bioengineering Abstracts KW - Unloading KW - cyclodextrin KW - Lipids KW - Oral administration KW - Pharmaceuticals KW - Drugs KW - Sex hormones KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21203560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bioactive+and+Compatible+Polymers&rft.atitle=Amorphous+Soluble+Cyclodextrins%3A+Pharmaceutical+and+Therapeutic+Uses&rft.au=Pitha%2C+Josef&rft.aulast=Pitha&rft.aufirst=Josef&rft.date=1988-01-01&rft.volume=3&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bioactive+and+Compatible+Polymers&rft.issn=08839115&rft_id=info:doi/10.1177%2F088391158800300206 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Unloading; cyclodextrin; Lipids; Oral administration; Pharmaceuticals; Drugs; Sex hormones DO - http://dx.doi.org/10.1177/088391158800300206 ER - TY - JOUR T1 - Carcinogenesis by nitroso-2-hydroxyethylurea in splenectomized hamsters. AN - 15473057; 2200481 AB - Several nitrosoalkylureas tested for carcinogenic activity in Syrian hamsters have as their main effect the induction of hemangiosarcomas of the spleen, many of which appear to metastasize to the liver. To investigate whether any of these lesions in the liver might not be metastases, a group of female Syrian hamsters was surgically splenectomized and treated with nitroso-2-hydroxythylurea (NHEU) dissolved in corn oil/ethyl acetate once a week for 22 weeks. The animals survived much longer (median 45 weeks) than a comparable group of unsplenectomized female hamsters given identical treatment (median 24 weeks). The absence of hemangiosarcomas of the liver in the splenectomized hamsters showed that the presumed metastases seen in intact animals were, in fact, just that. The compound did not produce a concomitant increase in tumors of other types. JF - Cancer Letters AU - Lijinsky, W AU - Kovatch, R M AU - Thomas, B J AD - NCI-Frederick Cancer Res. Facil., BRI-Basic Res. Program, Frederick, MD 21701, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 199 EP - 202 VL - 41 IS - 2 SN - 0304-3835, 0304-3835 KW - nitroso-2-hydroxyethylurea KW - hamsters KW - Toxicology Abstracts KW - carcinogenesis KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15473057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Letters&rft.atitle=Carcinogenesis+by+nitroso-2-hydroxyethylurea+in+splenectomized+hamsters.&rft.au=Lijinsky%2C+W%3BKovatch%2C+R+M%3BThomas%2C+B+J&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1988-01-01&rft.volume=41&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Cancer+Letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenesis ER - TY - JOUR T1 - Carcinogenesis by nitrosobis-(2-oxopropyl)amine labeled with deuterium and by nitroso-2-hydroxypropyl-2-oxopropylamine in rats and hamsters. AN - 15444832; 2179259 AB - The effects of the labeling with deuterium of the alpha -methylene groups of the carcinogen nitrosobis-(2-oxopropyl)amine (NBOP) on its carcinogenic effectiveness in rats and hamsters have been studied. The greater strength of the C-D bond compared with the C-H bond often leads to slower metabolism and lesser carcinogenic activity. When NBOP and NBOP-d sub(4) were given to male and female rats in drinking water at equimolar doses, the mortality rate from tumors was lower in the rats given the deuterium-labeled compound, although the results were statistically significant only in males. The incidences of tumors of several groups was similar for NBOP and NBOP-d sub(4), but there was a marked difference between males and females, females having a high incidence of liver tumors, and males very few. JF - Cancer Letters AU - Lijinsky, W AU - Saavedra, JE AU - Kovatch, R M AD - NCI-Frederick Cancer Res. Fac., BRI-Basic Res. Program, Frederick, MD 21701, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 37 EP - 41 VL - 42 IS - 1-2 SN - 0304-3835, 0304-3835 KW - N-nitrosobis(2-oxopropyl)amine KW - nitroso-2-hydroxypropyl-2-oxopropylamine KW - rats KW - hamsters KW - deuterium KW - Toxicology Abstracts KW - carcinogenesis KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15444832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Letters&rft.atitle=Carcinogenesis+by+nitrosobis-%282-oxopropyl%29amine+labeled+with+deuterium+and+by+nitroso-2-hydroxypropyl-2-oxopropylamine+in+rats+and+hamsters.&rft.au=Lijinsky%2C+W%3BSaavedra%2C+JE%3BKovatch%2C+R+M&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1988-01-01&rft.volume=42&rft.issue=1-2&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Cancer+Letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenesis ER - TY - JOUR T1 - Inactivity of fecapentaene-12 as a rodent carcinogen or tumor initiator. AN - 15443891; 2179165 AB - The possible carcinogenic activity of synthetic fecapentaene-12 (FP-12) was studied in several mammalian test systems: for carcinogenicity by intrarectal instillation in male F344/NCr rats as well as by intrarectal and subcutaneous application in male B6C3F1 mice; for initiation by skin painting in female SENCAR mice followed by repeated applications of 12-O-tetradecanoylphorbol-13-acetate (TPA), with 7,12-dimethylbenz(a)anthracene (DMBA) followed by TPA as positive control; in a rat subcutaneous granuloma pouch assay in which mutagenicity was measured by induction of 6-thioguanine (6-TG) resistance and carcinogenicity was determined by induction of subcutaneous tumors in the pouch. There was no significant increase in tumor incidence after 72-78 weeks, although 2 rats receiving FP-12 intrarectally developed colon polyps. JF - Cancer Letters AU - Ward, J M AU - Anjo, T AU - Ohannesian, L AU - Keefer, L K AU - Devor, DE AU - Donavan, P J AU - Smith, G T AU - Henneman, J R AU - Streeter, A J AD - NCI-FCRF, Build. 538, Frederick, MD 21701-1013, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 49 EP - 59 VL - 42 IS - 1-2 SN - 0304-3835, 0304-3835 KW - fecapentaene-12 KW - rats KW - mice KW - Toxicology Abstracts KW - carcinogenicity KW - X 24120:Food, additives & contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15443891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Letters&rft.atitle=Inactivity+of+fecapentaene-12+as+a+rodent+carcinogen+or+tumor+initiator.&rft.au=Ward%2C+J+M%3BAnjo%2C+T%3BOhannesian%2C+L%3BKeefer%2C+L+K%3BDevor%2C+DE%3BDonavan%2C+P+J%3BSmith%2C+G+T%3BHenneman%2C+J+R%3BStreeter%2C+A+J&rft.aulast=Ward&rft.aufirst=J&rft.date=1988-01-01&rft.volume=42&rft.issue=1-2&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Cancer+Letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity ER - TY - JOUR T1 - Genetics and biological markers of risk for alcoholism. AN - 15286446; 2044003 AB - Substantial scientific evidence has accumulated that both genetic and environmental factors predispose the development of alcoholism in certain individuals. Evidence has accumulated to indicate that alcoholism is a heterogeneous entity arising from multiple etiologies. The demonstrated role of genetics in increasing the risk of alcoholism has promoted the search for biological markers that could objectively identify individuals who are genetically predisposed to alcoholism. Identifying such markers could allow for early diagnosis, focused prevention, and differential and type-specific treatment of alcoholism. Promising markers have been provided by research in electrophysiology, endocrinology, and biochemistry. JF - Public Health Reports AU - Tabakoff, B AU - Hoffman, P L AD - NIAAA Intramural Res. Program, NIH Clin. Cent., Rm. 10/3c-103, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 690 EP - 698 VL - 103 IS - 6 SN - 0033-3549, 0033-3549 KW - biology KW - alcoholism KW - aetiology KW - Health & Safety Science Abstracts KW - genetics KW - public health KW - H SM10.20:ALCOHOLISM KW - H SM5.8.4:DRUGS AND ALCOHOL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15286446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=Genetics+and+biological+markers+of+risk+for+alcoholism.&rft.au=Tabakoff%2C+B%3BHoffman%2C+P+L&rft.aulast=Tabakoff&rft.aufirst=B&rft.date=1988-01-01&rft.volume=103&rft.issue=6&rft.spage=690&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - genetics; public health ER - TY - JOUR T1 - Preliminary crystallographic study of a retroviral protease. AN - 15260404; 2009853 AB - Crystals of Rous sarcoma virus protease, suitable for X-ray structural analysis, were obtained by the method of vapor diffusion using ammonium sulfate as the precipitant. The protease crystallized in the space group P3 sub(1)21 (a = b = 88.8 angstrom, c = 78.8 angstrom) with two molecules in the asymmetric unit. Native data have been collected to 2 multiplied by 5 resolution and the search for heavy-atom derivatives is in progress. JF - Journal of Molecular Biology AU - Miller, M AU - Leis, J AU - Wlodawer, A AD - Crystallogr. Lab., NCI-FCRF, BRI-Basic Res. Program, P.O. Box B, Frederick, MD 21701, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 211 EP - 212 VL - 204 IS - 1 SN - 0022-2836, 0022-2836 KW - Rous sarcoma virus KW - X-ray crystallography KW - proteinase KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - V 22189:Miscellaneous topics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15260404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Preliminary+crystallographic+study+of+a+retroviral+protease.&rft.au=Miller%2C+M%3BLeis%2C+J%3BWlodawer%2C+A&rft.aulast=Miller&rft.aufirst=M&rft.date=1988-01-01&rft.volume=204&rft.issue=1&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Primary structure of rat chromogranin A and distribution of its mRNA. AN - 15257138; 2014861 AB - The primary structure of rat chromogranin A has been deduced from a rat adrenal cDNA clone. A comparison of rat and bovine chromogranin A reveals several similar features: clusters of polyglutamic acid, similar amino acid composition, position of seven of 10 pairs of basic amino acids, identical placement of the only two cysteine residues, a highly conserved N- and C-terminus, and a sequence homologous to porcine pancreastatin 1-49. Unique features of rat chromogranin A are an eicosaglutamine sequence and two potential N-linked glycosylation sites. JF - FEBS Letters AU - Iacangelo, A AU - Okayama, H AU - Eiden, LE AD - Lab. Cell Biol., Build. 36, Rm. 3A-17, NIMH, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 115 EP - 121 VL - 227 IS - 2 SN - 0014-5793, 0014-5793 KW - adrenal medulla KW - amino acid sequence KW - chromogranin A KW - predictions KW - rats KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15257138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Primary+structure+of+rat+chromogranin+A+and+distribution+of+its+mRNA.&rft.au=Iacangelo%2C+A%3BOkayama%2C+H%3BEiden%2C+LE&rft.aulast=Iacangelo&rft.aufirst=A&rft.date=1988-01-01&rft.volume=227&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - The importance of the phenyl-tropholone "aS" configuration in colchicine's binding to tubulin. AN - 15255893; 2014388 AB - Measuring ellipticities of ( plus or minus )-colchicine and ( plus or minus )-deacetamidocolchicine in the presence of tubulin afforded net positive CD bands with maxima at 340 nm resulting from reduction of the negative ellipticities upon binding of (-) enantiomers to the protein. Results of optical studies together with earlier NMR conformational analysis of these molecules substantiate the hypothesis that colchicinoids bind to tubulin with the phenyl-tropolone moiety in the "aS" configuration. Natural colchicine which binds to tubulin, therefore, should be referred to as (-)-(aS,7S)-colchicine. JF - FEBS Letters AU - Yeh, HJC AU - Chranowska, M AU - Brossi, A AD - Lab. Anal. Chem., NIDDK, Natl. Inst. Health, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 82 EP - 86 VL - 229 IS - 1 SN - 0014-5793, 0014-5793 KW - C.D. KW - albumin KW - binding KW - colchicine KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15255893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=The+importance+of+the+phenyl-tropholone+%22aS%22+configuration+in+colchicine%27s+binding+to+tubulin.&rft.au=Yeh%2C+HJC%3BChranowska%2C+M%3BBrossi%2C+A&rft.aulast=Yeh&rft.aufirst=HJC&rft.date=1988-01-01&rft.volume=229&rft.issue=1&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Recognition of the P1 plasmid centromere analog involves binding of the ParB protein and is modified by a specific host factor. AN - 15231590; 1996397 AB - The P1 plasmid partition system is responsible for segregation of daughter plasmids during division of the Escherichia coli host cell. The P1-encoded elements consists of two essential proteins, ParA and ParB, and the cis-acting inc B region. The inc B region determines partition-mediated incompatibility and contains the centromere-like site par S. The authors have isolated and purified the two proteins. ParB binds specifically to the inc B region in vitro. Information for host-factor binding lies in the region determining the specificity of plasmid incompatibility. The roles of parB and the host factor in partition and the specificity of plasmid incompatibility are discussed. JF - EMBO Journal AU - Davis, MA AU - Austin, S J AD - Lab. Chromosome Biol., BRI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 1881 EP - 1888 VL - 7 IS - 6 SN - 0261-4189, 0261-4189 KW - P1 plasmid KW - partition KW - systems KW - centromeres KW - Escherichia coli KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - DNA-binding protein KW - plasmids KW - N 14930:Transcription factors KW - J 02760:Plasmids KW - G 07200:P PLASMIDS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15231590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+Journal&rft.atitle=Recognition+of+the+P1+plasmid+centromere+analog+involves+binding+of+the+ParB+protein+and+is+modified+by+a+specific+host+factor.&rft.au=Davis%2C+MA%3BAustin%2C+S+J&rft.aulast=Davis&rft.aufirst=MA&rft.date=1988-01-01&rft.volume=7&rft.issue=6&rft.spage=1881&rft.isbn=&rft.btitle=&rft.title=EMBO+Journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - DNA-binding protein; plasmids ER - TY - JOUR T1 - Retinal degeneration in the mouse induced transplacentally by N-methyl-N-nitrosourea: Effects of constant illumination or total darkness. AN - 15230296; 1987108 AB - The DNA alkylating agent, N-methyl-N-nitrosourea (MNU), when administered prenatally (on day 16 of gestation) provokes a progressive retinal degeneration in CD-1 albino mice reared in standard fluorescent lighting conditions (12 L : 12 D). This degeneration begins at about 4 weeks postnatally and worsens with age. To determine whether light was essential to the development of this lesion, animals were maintained in either constant light or constant darkness. Systematic measurement of the inner and outer segment lengths, the number of rows of photoreceptor cells and the thickness of the outer nuclear layer and whole retina were made to quantify degenerative changes in animals at 2-, 4-, 6-, 8-, 12-, and 16 weeks of age. The constant light caused a drastic reduction in thickness of the retinas of MNU-treated and control mice. The MNU-exposed animals reared in the dark did not demonstrate this reduction in retinal thickness, at least up to 16 weeks of age. JF - Experimental Cell Research AU - Smith, S B AU - Hashimi, W AU - Yielding, K L AD - Build. 6, Rm. B1-A04, NEI, Natl. Inst. Health, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 347 EP - 359 VL - 47 IS - 3 SN - 0014-4827, 0014-4827 KW - N-methyl-N-nitrosourea KW - degeneration KW - mice KW - Toxicology Abstracts KW - prenatal experience KW - light KW - retina KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15230296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Cell+Research&rft.atitle=Retinal+degeneration+in+the+mouse+induced+transplacentally+by+N-methyl-N-nitrosourea%3A+Effects+of+constant+illumination+or+total+darkness.&rft.au=Smith%2C+S+B%3BHashimi%2C+W%3BYielding%2C+K+L&rft.aulast=Smith&rft.aufirst=S&rft.date=1988-01-01&rft.volume=47&rft.issue=3&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Experimental+Cell+Research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - retina; prenatal experience; light ER - TY - JOUR T1 - Synthesis and anticholinesterase activity of (-)-N super(1)-Norphysostigmine, (-)-eseramine, and other N(1)-substituted analogues of (-)-physostigmine. AN - 15226247; 1989625 AB - (-)-N super(1)-Benzylnorphysostigmine, prepared from synthetic (-)-O-methyl-N super(1)-noreseroline by N-benzylation, ether cleavage, and reaction of (-)-N super(1)-benzylnoreseroline with methyl isocyanate, was the intermediate used to prepare the title compounds. JF - Journal of Medicinal Chemistry AU - Yu, Qian-Sheng AU - Atack, J R AU - Rapoport, SI AU - Brossi, A AD - Med. Chem. Sect., Lab. Anal. Chem., NIDDK, Lab. Neurosci., NIA, Natl. Inst. Health, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 2297 EP - 2300 VL - 31 IS - 12 SN - 0022-2623, 0022-2623 KW - activity KW - analogs KW - cholinesterase KW - inhibitors KW - physostigmine KW - synthesis KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15226247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Synthesis+and+anticholinesterase+activity+of+%28-%29-N+super%281%29-Norphysostigmine%2C+%28-%29-eseramine%2C+and+other+N%281%29-substituted+analogues+of+%28-%29-physostigmine.&rft.au=Yu%2C+Qian-Sheng%3BAtack%2C+J+R%3BRapoport%2C+SI%3BBrossi%2C+A&rft.aulast=Yu&rft.aufirst=Qian-Sheng&rft.date=1988-01-01&rft.volume=31&rft.issue=12&rft.spage=2297&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Oligomeric structure of p21 ras proteins as determined by radiation inactivation. AN - 15199645; 1968954 AB - Using radiation inactivation the authors determined that p21 ras proteins exhibit an oligomeric target size when assayed both structurally and functionally. Similar target sizes of p21 in ras-transformed cells and in purified preparations of the protein suggested that its structure is homo-oligomeric. p21 monomers were destroyed by radiation with the same target size as the GTP binding activity, indicating the occurrence of a tight association allowing energy transfer between the monomers. JF - Journal of Biological Chemistry AU - Santos, E AU - Nebreda, A R AU - Bryan, T AU - Kempner, E S AD - Lab. Mol. Microbiol., NIAID, NIH, Build. 5, Rm. B1-26, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 9853 EP - 9858 VL - 263 IS - 20 SN - 0021-9258, 0021-9258 KW - genes KW - inactivation KW - mice KW - oligomeric KW - oncogenes KW - protein p21 KW - radiation KW - ras gene KW - structure KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - G 07398:GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15199645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Oligomeric+structure+of+p21+ras+proteins+as+determined+by+radiation+inactivation.&rft.au=Santos%2C+E%3BNebreda%2C+A+R%3BBryan%2C+T%3BKempner%2C+E+S&rft.aulast=Santos&rft.aufirst=E&rft.date=1988-01-01&rft.volume=263&rft.issue=20&rft.spage=9853&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - radiation; genes ER - TY - JOUR T1 - Neurotoxic damage to the nigrostriatal system in rats following intranigral administration of MPDP super(+) and MPP super(+). AN - 15195374; 1975842 AB - Unilateral intranigral administration of the oxidative metabolites of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenyl-dihydropyridine (MPDP super(+)) or 1-methyl-4-phenylpyridine (MPP super(+)) produced dose-dependently a depletion of dopamine in the ipsilateral striatum of rats two weeks following treatment. MPP super(+) increased the super(45)Ca accumulation into cells at the site of injection and produced "nonspecific" cell membrane and/or cytotoxic damage seen by histological procedures. The results indicate that MPDP super(+) and MPP super(+) produced localized cytotoxic damage to nigrostriatal neurons, caused a decrease in striatal dopamine, and disrupted the nigrostriatal system's functioning following intranigral administration to rats. JF - Journal of Neural Transmission AU - Sun, C J AU - Johannessen, J N AU - Gessner, W AU - Namura, I AU - Singhaniyom, W AU - Brossi, A AU - Chiueh, C C AD - Lab. Cerebral Metab., NIMH, NIH, Build. 10, Rm. 2 D-52, Bethesda, MD 20892-1000, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 75 EP - 86 VL - 74 IS - 2 SN - 0300-9564, 0300-9564 KW - MPP super(+) KW - administration KW - effects on KW - rats KW - comparison KW - MPDP super(+) KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - neurotoxicity KW - substantia nigra KW - neostriatum KW - N3 11104:Mammals (except primates) KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15195374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aabiglobal&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Political+Science+Quarterly&rft.atitle=The+Political+and+Economic+Forces+Shaping+Concentrated+Poverty&rft.au=Wilson%2C+William+Julius&rft.aulast=Wilson&rft.aufirst=William&rft.date=2008-12-01&rft.volume=123&rft.issue=4&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Political+Science+Quarterly&rft.issn=00323195&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - substantia nigra; neurotoxicity; neostriatum ER - TY - JOUR T1 - A perspective on science and public health policy. AN - 15189364; 1966579 JF - Public Health Reports AU - Gordis, E AD - NIAAA, Rm. 16-105 Parklawn Build., 5600 Fishers Lane, Rockville, MD 20857, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 575 EP - 577 VL - 103 IS - 6 SN - 0033-3549, 0033-3549 KW - public health KW - research and development KW - alcoholism KW - Health & Safety Science Abstracts KW - training KW - federal policies KW - H SM3.5:STANDARDS, LAWS, REGULATIONS, AND POLICY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15189364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=A+perspective+on+science+and+public+health+policy.&rft.au=Gordis%2C+E&rft.aulast=Gordis&rft.aufirst=E&rft.date=1988-01-01&rft.volume=103&rft.issue=6&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - training; federal policies ER - TY - JOUR T1 - Screening for alcoholism: Techniques and issues. AN - 15189170; 1966550 AB - Alcoholism is an often overlooked health problem because alcoholics usually do not seek treatment for their drinking problems. They do, however, seek general medical care for other health reasons, and a number of screening techniques have proven useful for identifying alcoholics. The advantages and disadvantages of self-report, as well as biochemical techniques that have been found effective in screening for alcoholism, are discussed. JF - Public Health Reports AU - Allen, J P AU - Eckardt, MJ AU - Wallen, J AD - NIAAA, Treat. Res. Branch, Parklawn 16-C03, Rockville, MD 20857, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 586 EP - 592 VL - 103 IS - 6 SN - 0033-3549, 0033-3549 KW - alcoholism KW - screening KW - research and development KW - Health & Safety Science Abstracts KW - H SM10.20:ALCOHOLISM UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15189170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=Screening+for+alcoholism%3A+Techniques+and+issues.&rft.au=Allen%2C+J+P%3BEckardt%2C+MJ%3BWallen%2C+J&rft.aulast=Allen&rft.aufirst=J&rft.date=1988-01-01&rft.volume=103&rft.issue=6&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Alcoholism treatment service systems: A health services research perspective. AN - 15186537; 1966526 AB - This article examines the role of health services research in alcoholism treatment. Alcoholism services research has only recently emerged as a self-defined discipline. Alcoholism services research can be grouped into five classifications: a) descriptive studies of resources for alcoholism treatment and of the use or cost of these services, b) estimates of the need or demand for alcohol services in the population or in particular subpopulations, c) studies of the costs or cost-effectiveness of alcoholism treatment or of alternative treatments, d) studies of the possible "cost-offsets" of treating alcoholism, and e) studies that examine strategies for financing and reimbursement for alcoholism treatment. JF - Public Health Reports AU - Wallen, J AD - NIAAA, Parklawn Build., Rm. 16C-05, Rockville, MD 20852, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 605 EP - 611 VL - 103 IS - 6 SN - 0033-3549, 0033-3549 KW - alcoholism KW - cost benefit analysis KW - Health & Safety Science Abstracts KW - economics KW - public health KW - H SM10.20:ALCOHOLISM UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15186537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=Alcoholism+treatment+service+systems%3A+A+health+services+research+perspective.&rft.au=Wallen%2C+J&rft.aulast=Wallen&rft.aufirst=J&rft.date=1988-01-01&rft.volume=103&rft.issue=6&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - economics; public health ER - TY - JOUR T1 - Cortisol response to clonidine in panic disorder: Comparison with depressed patients and normal controls. AN - 15186499; 1967122 AB - Abnormalities in regulation of noradrenergic function have been proposed as part of the pathology of depressive and panic anxiety disorders. However, abnormalities in hypothalamic-pituitary-adrenal (HPA) axis function have largely been limited to patients with depressive disorders. Using the cortisol response to clonidine, an alpha sub(2)-adrenergic receptor agonist, this study examined the relationship between the noradrenergic system and the HPA axis in 10 patients with major depression (4 unipolar, 6 bipolar), 10 patients with panic disorder, and 10 normal controls. Baseline cortisol was significantly elevated in depressed as compared with panic patients, but not with controls. JF - Biological Psychiatry AU - Stein, M B AU - Uhde, T W AD - Unit Anxiety and Affective Disord., BPB, NIMH, Build. 10, Rm 3S239, 9000 Rockville Pike, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 322 EP - 330 VL - 24 IS - 3 SN - 0006-3223, 0006-3223 KW - panic disorders KW - cortisol KW - clonidine KW - Health & Safety Science Abstracts KW - psychology KW - H SM9.7:HUMAN FACTORS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15186499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Psychiatry&rft.atitle=Cortisol+response+to+clonidine+in+panic+disorder%3A+Comparison+with+depressed+patients+and+normal+controls.&rft.au=Stein%2C+M+B%3BUhde%2C+T+W&rft.aulast=Stein&rft.aufirst=M&rft.date=1988-01-01&rft.volume=24&rft.issue=3&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Biological+Psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - psychology ER - TY - JOUR T1 - A heat-shock-inducible eukaryotic expression vector. AN - 15178571; 1956899 AB - The authors describe a construct, pHS/Cla, containing the Drosophila melanogaster hsp70 promoter which serves as an inducible expression vector in mammalian cells. The construct was made in the plasmid pAT153, a derivative of pBR322. In transient transfections of human H9 T-cells, the transactivator of transcription protein of the human AIDS virus HIV-1 was functionally expressed in response to heat shock. The promoter is very tightly regulated in that no expression can be detected at 37 degree C. The construct contains a unique ClaI site for cloning and expressing potentially any gene. JF - Gene AU - Schweinfest, C W AU - Jorcyk, CL AU - Fujiwara, S AU - Papas, T S AD - Lab. Mol. Oncol., NCI, Frederick, MD 21701-1013, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 207 EP - 210 VL - 71 IS - 1 SN - 0378-1119, 0378-1119 KW - hsp70 gene KW - AIDS KW - immunodeficiency virus 1 (human) KW - pHS/Cla plasmid KW - derivatives KW - pAT153 plasmid KW - pBR322 plasmid KW - transactivator protein KW - expression KW - cloning vectors KW - genes KW - plasmids KW - promoters KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - W 30114:Cloning vectors KW - N 14682:Cloning vectors KW - G 07200:P PLASMIDS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15178571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=A+heat-shock-inducible+eukaryotic+expression+vector.&rft.au=Schweinfest%2C+C+W%3BJorcyk%2C+CL%3BFujiwara%2C+S%3BPapas%2C+T+S&rft.aulast=Schweinfest&rft.aufirst=C&rft.date=1988-01-01&rft.volume=71&rft.issue=1&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - genes; promoters; plasmids; cloning vectors ER - TY - JOUR T1 - Sequencing and synthesis of pardaxin, a polypeptide from the Red Sea Moses sole with ionophore activity. AN - 15146692; 1920562 AB - Pardaxin, an amphipathic polypeptide secreted by the Red Sea flatfish Pardachirus marmoratus was synthesized by the solid-phase method. The structure was verified by sequencing. The synthetic polypeptide changed the resistance of lipid bilayers by forming pores. Synthetic pardaxin seems to be a suitable tool for investigating the molecular structures underlying channel selectivity. JF - FEBS Letters AU - Shai, Y AU - Fox, J AU - Caratsch, C AU - Shih, Yu-Liang AU - Edwards, C AU - Lazarovici, P AD - Lab. Cell Biol. and Genet., NIDDK, Natl. Inst. Health, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 161 EP - 166 VL - 242 IS - 1 SN - 0014-5793, 0014-5793 KW - Pardachirus marmoratus KW - amino acid sequence KW - neurotoxins KW - new products KW - pardaxin KW - peptide synthesis KW - polypeptides KW - synthetic pardaxin KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - Q1:08524 KW - Q1 08625:Non-edible products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15146692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Sequencing+and+synthesis+of+pardaxin%2C+a+polypeptide+from+the+Red+Sea+Moses+sole+with+ionophore+activity.&rft.au=Shai%2C+Y%3BFox%2C+J%3BCaratsch%2C+C%3BShih%2C+Yu-Liang%3BEdwards%2C+C%3BLazarovici%2C+P&rft.aulast=Shai&rft.aufirst=Y&rft.date=1988-01-01&rft.volume=242&rft.issue=1&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - neurotoxins; polypeptides; new products; Marine ER - TY - JOUR T1 - The P1 plasmid-partition system synthesizes two essential proteins from an autoregulated operon. AN - 15145429; 1934578 AB - The P1 partition region contains two large open reading frames that encode the proteins ParA and ParB. It was previously shown that ParA is essential for partition activity. Using a novel assay, the authors show that ParB protein is also an absolute requirement for partition and that it is active in trans to the partitioning plasmid. Development of complementation tests for parA and parB allow them to assign a number of partition-defective point mutants of a P1 miniplasmid to the parA and parB cistrons. Using gene fusion techniques, it was shown that parA and parB constitute and operon controlled from a promoter proximal to the star of parA . JF - Plasmid AU - Friedman, SA AU - Austin, S J AD - Lab. Chromosome Biol., BRI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 103 EP - 112 VL - 19 IS - 2 SN - 0147-619X, 0147-619X KW - plasmid P1 KW - genes KW - ParB protein KW - requirements KW - partioning KW - ParA protein KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - plasmids KW - J 02760:Plasmids KW - G 07200:P PLASMIDS KW - N 14662:Gene regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15145429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plasmid&rft.atitle=The+P1+plasmid-partition+system+synthesizes+two+essential+proteins+from+an+autoregulated+operon.&rft.au=Friedman%2C+SA%3BAustin%2C+S+J&rft.aulast=Friedman&rft.aufirst=SA&rft.date=1988-01-01&rft.volume=19&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Plasmid&rft.issn=0147619X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - plasmids ER - TY - JOUR T1 - Receptors with V sub(1) characteristics mediate the maintenance of ethanol tolerance by vasopressin. AN - 15137870; 1928053 AB - The neurohypohyseal hormone arginine vasopressin (AVP) acts in the central nervous system (CNS) to maintain functional tolerance to several effects of ethanol. The ability of exogenous vasopressin (administered i.c.v.) to maintain tolerance to the hypnotic effect was blocked more effectively by antagonists acting at V sub(1) receptors than by a V sub(2)-selective antagonist. JF - Journal of Pharmacology and Experimental Therapeutics AU - Szabo, G AU - Tabakoff, B AU - Hoffman, P L AD - NIAAA/LPPS, 12501 Washington Ave., Rockville, MD 20852, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 536 EP - 541 VL - 247 IS - 2 SN - 0022-3565, 0022-3565 KW - vasopressin V1 KW - receptors KW - mediation KW - laboratory animals KW - ethanol KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - brain KW - drug tolerance KW - N3 11104:Mammals (except primates) KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15137870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmacology+and+Experimental+Therapeutics&rft.atitle=Receptors+with+V+sub%281%29+characteristics+mediate+the+maintenance+of+ethanol+tolerance+by+vasopressin.&rft.au=Szabo%2C+G%3BTabakoff%2C+B%3BHoffman%2C+P+L&rft.aulast=Szabo&rft.aufirst=G&rft.date=1988-01-01&rft.volume=247&rft.issue=2&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmacology+and+Experimental+Therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - drug tolerance; brain ER - TY - JOUR T1 - Toxic agent and radiation control: Progress toward objectives for the nation for the year 1990. AN - 15135006; 1918527 AB - In 1980, the Department of Health and Human Services set national prevention objectives for 1990 in 15 health priority areas, 1 of which is the control of toxic agents and radiation. Ten objectives related to this area are priorities for the national control effort. progress is reviewed on those priorities within the responsibilities of the Public Health Service. JF - Public Health Reports AU - Rall, D P AD - Off. Program Plann. and Eval., NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 342 EP - 347 VL - 103 IS - 4 SN - 0033-3549, 0033-3549 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - radiation KW - toxic materials KW - environmental protection KW - public health KW - pollution control KW - H SM3.1:BASIC APPROACHES, CONCEPTS, AND THEORY KW - P 9000:ENVIRONMENTAL ACTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15135006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=Toxic+agent+and+radiation+control%3A+Progress+toward+objectives+for+the+nation+for+the+year+1990.&rft.au=Rall%2C+D+P&rft.aulast=Rall&rft.aufirst=D&rft.date=1988-01-01&rft.volume=103&rft.issue=4&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - toxic materials; radiation; pollution control; public health; environmental protection ER - TY - JOUR T1 - Inhibitory effect of zinc on nickel subsulfide carcinogenesis in Fischer rats. AN - 15128845; 1917967 AB - The effects of zinc oxide (ZnO) and zinc acetate (ZnAcet) administered i.m. together with nickel subsulfide (Ni sub(3)S sub(2)), a potent muscle carcinogen, were observed over 66 weeks in male F344/NCr rats. In rats given Ni sub(3)S sub(2) alone the incidence of local tumors reached 100% in 40 weeks. In rats treated locally with Ni sub(3)S sub(2) + ZnO or znAcet, the tumor incidence at week 40 was only 40-60%; it reached 85-100% in 66 weeks, with no significant differences among the treatments. Treatment with i.m. Ni sub(3)S sub(2) + s.c. ZnO resulted in 100% muscle tumors at week 58. One local tumor was found in rats given ZnO alone and none in the water injected animals. Statistical analysis revealed highly significant differences in the tumor occurrence rates between rats treated with Ni sub(3)S sub(2) alone and rats treated with Ni sub(3)S sub(2) combined with ZnO or ZnAcet, whereas the final tumor incidences at week 66 were not different. The first tumors were found at weeks 24-31 regardless of the treatment. Hence, administration of zinc slows the carcinogenic process induced by nickel. JF - Toxicology AU - Kasprzak, K S AU - Kovatch, R M AU - Poirier, LA AD - Bldg. 538, Rm. 205, NCI-FCRF, Frederick, MD 21701-1013, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 253 EP - 262 VL - 52 IS - 3 SN - 0300-483X, 0300-483X KW - nickel subsulfide KW - zinc KW - rats KW - heavy metals KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - carcinogenesis KW - H SE4.20:POISONS AND POISONING KW - X 24162:Chronic exposure KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15128845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Inhibitory+effect+of+zinc+on+nickel+subsulfide+carcinogenesis+in+Fischer+rats.&rft.au=Kasprzak%2C+K+S%3BKovatch%2C+R+M%3BPoirier%2C+LA&rft.aulast=Kasprzak&rft.aufirst=K&rft.date=1988-01-01&rft.volume=52&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - zinc; carcinogenesis; rats; heavy metals ER - TY - JOUR T1 - Stimulation of phosphoribosyl pyrophosphate and purine nucleotide production by pyrroline 5-carboxylate in human erythrocytes. AN - 15125734; 1915964 AB - Recent studies have shown that pyrroline 5-carboxylate, the intermediate in the interconversions of proline, ornithine, and glutamate, can regulate the metabolism of erythrocytes. The authors report that the formation of 5-phosphoribosyl 1-pyrophosphate (PP-Rib-P) was markedly stimulated by pyrroline 5-carboxylate in intact red cells. The production of PP-Rib-P is an important point of regulation in nucleotide metabolism. The authors now report that pyrroline 5-carboxylate markedly stimulated the net synthesis of inosine monophosphate from hypoxanthine in intact human red cells so that the pool of inosine monophosphate became 20-30% of the total pool of purine nucleotides. JF - Journal of Biological Chemistry AU - Yeh, Grace Chao AU - Phang, James M AD - Build. 10, Rm. 4N117, NCI, NIH, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 13083 EP - 13089 VL - 263 IS - 26 SN - 0021-9258, 0021-9258 KW - biosynthesis KW - erythrocytes KW - man KW - phosphoribosyl pyrophosphate KW - purine nucleotides KW - pyrroline 5-carboxylate KW - stimulation KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15125734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Stimulation+of+phosphoribosyl+pyrophosphate+and+purine+nucleotide+production+by+pyrroline+5-carboxylate+in+human+erythrocytes.&rft.au=Yeh%2C+Grace+Chao%3BPhang%2C+James+M&rft.aulast=Yeh&rft.aufirst=Grace&rft.date=1988-01-01&rft.volume=263&rft.issue=26&rft.spage=13083&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Basal ppGpp level adjustment shown by new spoT mutants affect steady state growth rates and rrnA ribosomal promoter regulation in Escherichia coli . AN - 15124323; 1913379 AB - This work describes an approach towards analyzing the regulatory effects of variation of guanosine 3',5'-bispyrophosphate (ppGpp) basal levels in Escherichia coli during steady state growth. A series of strains was derived by mutating the spoT gene (which encodes the major cellular ppGppase) so as to obtain systematic increments in ppGpp basal levels. Measurements of ppGpp revealed a ten-fold range of basal levels during growth on minimal medium. The empirical relationship between ppGpp concentration and growth rate is a simple linear inverse correlation. We conclude that there are systematic regulatory consequences associated with small changes in ppGpp basal levels during steady state growth that probably are part of a continuum with more dramatic effects observed during the stringent response to amino acid deprivation. JF - Molecular and General Genetics AU - Sarubbi, E AU - Rudd, KE AU - Cashel, M AD - Build. 6, Rm. 335, NICHD, NIH, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 214 EP - 222 VL - 213 IS - 2-3 SN - 0026-8925, 0026-8925 KW - growth rate KW - spoT gene KW - regulation KW - rrnA gene KW - promoters KW - mutants KW - effects on KW - levels KW - guanosine tetraphosphate KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - genes KW - Escherichia coli KW - G 07320:Bacterial genetics KW - N 14662:Gene regulation KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15124323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+General+Genetics&rft.atitle=Basal+ppGpp+level+adjustment+shown+by+new+spoT+mutants+affect+steady+state+growth+rates+and+rrnA+ribosomal+promoter+regulation+in+Escherichia+coli+.&rft.au=Sarubbi%2C+E%3BRudd%2C+KE%3BCashel%2C+M&rft.aulast=Sarubbi&rft.aufirst=E&rft.date=1988-01-01&rft.volume=213&rft.issue=2-3&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Molecular+and+General+Genetics&rft.issn=00268925&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; genes ER - TY - JOUR T1 - Rapid development of hepatocellular neoplasms in aging male C3H/HeNCr mice given phenobarbital. AN - 15118533; 1903275 AB - One hundred and nineteen male C3H/HeNCr mice, 12 months of age, with spontaneous preneoplastic and neoplastic hepatocellular lesions were given phenobarbital (PB) at 500 ppm in drinking water. In aging mice, PB exposure significantly increased the number of gross tumors or microscopic foci, adenomas or carcinomas per liver at all time periods, especially unique eosinophilic proliferative lesions, while young mice did not develop any focal proliferative lesions by 36 weeks. The findings suggest that in aging mice a fraction of the hepatocyte population (normal, spontaneously-initiated or preneoplastic) is more highly susceptible to phenobarbital "carcinogenesis" than are hepatocytes of younger mice. JF - Cancer Letters AU - Ward, J M AU - Lynch, P AU - Riggs, C AD - Tumor Pathol. and Pathogenesis Sect., Lab. Comp. Carcinogenesis, Natl. Cancer Inst., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701-1013, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 9 EP - 18 VL - 39 IS - 1 SN - 0304-3835, 0304-3835 KW - phenobarbital KW - mice KW - Toxicology Abstracts KW - age KW - liver KW - neoplasia KW - X 24112:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15118533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Letters&rft.atitle=Rapid+development+of+hepatocellular+neoplasms+in+aging+male+C3H%2FHeNCr+mice+given+phenobarbital.&rft.au=Ward%2C+J+M%3BLynch%2C+P%3BRiggs%2C+C&rft.aulast=Ward&rft.aufirst=J&rft.date=1988-01-01&rft.volume=39&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Cancer+Letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - liver; neoplasia; age ER - TY - JOUR T1 - Fetal hippocampal cell suspensions ameliorate behavioral effects of intradentate colchicine in the rat. AN - 15085283; 1881613 AB - Colchicine, a neurotoxin that preferentially destroys dentate gyrus granule cells and mossy fibers, was injected into the hippocampus of adult rats. Three weeks later, the rats were tested for colchicine-induced hypermotility after which they received fetal hippocampal explants. Locomotor activity was retested three weeks later, after which the rats were trained over a period of four weeks on a food-reinforced, spatial, working memory task in an 8-arm radial maze. Fetal hippocampal explants were found to attenuate significantly the colchicine-induced hypermotility and spatial learning deficits. Histological observations showed the presence of surviving hippocampal explants in both the lesioned and the control rat brains, suggesting that the presence of viable implants facilitates the recovery of behavioral function in rats with spatial memory deficits. JF - Brain Research AU - Tandon, P AU - McLamb, R L AU - Novicki, D AU - Shuey, D L AU - Tilson, HA AD - LMIN, NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 241 EP - 248 VL - 473 IS - 21 SN - 0006-8993, 0006-8993 KW - injection KW - pretreatment KW - effects on KW - rats KW - colchicine KW - Toxicology Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - dentate gyrus KW - transplants KW - granule cells KW - hippocampus KW - locomotion KW - Y 25767:Mammals (excluding primates) KW - X 24115:Pathology KW - N3 11132:Anatomical and surgical correlates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15085283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Fetal+hippocampal+cell+suspensions+ameliorate+behavioral+effects+of+intradentate+colchicine+in+the+rat.&rft.au=Tandon%2C+P%3BMcLamb%2C+R+L%3BNovicki%2C+D%3BShuey%2C+D+L%3BTilson%2C+HA&rft.aulast=Tandon&rft.aufirst=P&rft.date=1988-01-01&rft.volume=473&rft.issue=21&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - granule cells; dentate gyrus; hippocampus; transplants; locomotion ER - TY - JOUR T1 - A metabolite of the carcinogen 7,12-dimethylbenz(a)anthracene that reacts predominantly with adenine residues in DNA. AN - 15081796; 1883617 AB - Four 7,12-dimethylbenz(a)anthracene-deoxyribonucleoside adducts formed in mouse epidermis in vivo arise from the syn dihydrodiol epoxide metabolite of this carcinogen. With the synthetic syn dihydrodiol epoxide it was possible to identify three of these as deoxyadenosine adducts and to establish their structures. These three adducts account for the large majority of DNA adduct arising from this metabolite in vivo. The in vivo metabolite is unusual, therefore, in that it reacts almost exclusively with adenine residues in DNA while most carcinogen metabolites react preferentially with guanine residues. JF - Carcinogenesis AU - Cheng, S C AU - Prakash, A S AU - Pigott, MA AU - Hilton, B D AU - Lee, H AU - Harvey, R G AU - Dipple, A AD - BRI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 1721 EP - 1723 VL - 9 IS - 9 SN - 0143-3334, 0143-3334 KW - metabolites KW - interactions KW - 9,10-dimethyl-1,2-benzanthracene KW - adenine KW - Toxicology Abstracts KW - DNA KW - X 24190:Polycyclic hydrocarbons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15081796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=A+metabolite+of+the+carcinogen+7%2C12-dimethylbenz%28a%29anthracene+that+reacts+predominantly+with+adenine+residues+in+DNA.&rft.au=Cheng%2C+S+C%3BPrakash%2C+A+S%3BPigott%2C+MA%3BHilton%2C+B+D%3BLee%2C+H%3BHarvey%2C+R+G%3BDipple%2C+A&rft.aulast=Cheng&rft.aufirst=S&rft.date=1988-01-01&rft.volume=9&rft.issue=9&rft.spage=1721&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - DNA ER - TY - JOUR T1 - Genetic locus, primary structure, and chemical synthesis of human immunodeficiency virus protease. AN - 15073968; 1878858 AB - The genetic locus and primary structure of the human immunodeficiency virus (HIV) protease was determined by comparing the data of protein analyses with the published data of the gene analysis. The complete sequence of HIV-1 and HIV-2 protease was synthesized by solid-phase peptide synthesis. The synthetic protease was capable of accurately cleaving synthetic peptide substrates corresponding to know cleavage sites in gag polyproteins of HIV-1, HIV-2, and murine leukemia virus. The chemical synthesis of protease confirms the DNA sequence and provides a means of rapidly producing active protease in substantial quantities for biochemical and physical studies. JF - GENE ANAL. TECH. AU - Copeland, T D AU - Oroszlan, S AD - Lab. Mol. Virol. and Carcinogenesis, BRI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 109 EP - 115 VL - 5 IS - 6 KW - activity KW - amino acid sequence KW - correlation KW - genes KW - human immunodeficiency virus 1 KW - human immunodeficiency virus 2 KW - nucleotide sequence KW - peptide synthesis KW - proteinase KW - proteolysis KW - solid phase methods KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - V 22002:AIDS: Molecular and in vitro aspects KW - V 22032:Viral proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15073968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=GENE+ANAL.+TECH.&rft.atitle=Genetic+locus%2C+primary+structure%2C+and+chemical+synthesis+of+human+immunodeficiency+virus+protease.&rft.au=Copeland%2C+T+D%3BOroszlan%2C+S&rft.aulast=Copeland&rft.aufirst=T&rft.date=1988-01-01&rft.volume=5&rft.issue=6&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=GENE+ANAL.+TECH.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - nucleotide sequence; peptide synthesis; genes; amino acid sequence; activity ER - TY - JOUR T1 - Chemical and immunological characterization of the 21-kDa ADP-ribosylation factor of adenylate cyclase. AN - 15057192; 1848285 AB - The ADP-ribosylation factor (ARF) is a 21-kDa GTP-binding protein cofactor in the cholera toxin-catalyzed ADP-ribosylation of the stimulatory regulatory subunit of adenylate cyclase. Purified bovine brain ARF was digested with cyanogen bromide, and peptides were purified and sequenced. Approximately 25-30% of the protein was sequenced in this manner. Peptides contained consensus sequences for GTP-binding proteins but were distinct from any of the previously published GTP-binding proteins. JF - Journal of Biological Chemistry AU - Kahn, R A AU - Goddard, C AU - Newkirk, M AD - Build. 37, Rm. 5D-02, NCI, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 8282 EP - 8287 VL - 263 IS - 17 SN - 0021-9258, 0021-9258 KW - ADP-ribosylation factor KW - adenylate cyclase KW - amino acid sequence KW - brain KW - cattle KW - characterization KW - cholera toxin KW - immunochemistry KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15057192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Chemical+and+immunological+characterization+of+the+21-kDa+ADP-ribosylation+factor+of+adenylate+cyclase.&rft.au=Kahn%2C+R+A%3BGoddard%2C+C%3BNewkirk%2C+M&rft.aulast=Kahn&rft.aufirst=R&rft.date=1988-01-01&rft.volume=263&rft.issue=17&rft.spage=8282&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Menopause and ovarian cancer. AN - 15056007; 1845129 AB - Using data from a study of 296 patients diagnosed in greater Washington, D.C., from 1978 to 1981 with primary epithelial ovarian cancer and 343 patients hospitalized for other conditions, the authors estimated the rate ratios according to various characteristics of the menopause. Menopause induced by hysterectomy with preservation of both ovaries was associated with a 30 per cent reduction in risk of later development of ovarian cancer. Age at natural menopause was not consistently related to risk. Women who used menopausal estrogens showed a 40 per cent decreased risk. JF - American Journal of Epidemiology AU - Hartge, P AU - Hoover, R AU - McGowan, L AU - Lesher, L AU - Norris, HJ AD - NCI, Landow Build., Rm. 3C06, NIH, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 990 EP - 998 VL - 127 IS - 5 SN - 0002-9262, 0002-9262 KW - menopause KW - estrogens KW - Health & Safety Science Abstracts KW - risk assessment KW - epidemiology KW - cancer KW - H SM10.21:CANCER UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15056007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Menopause+and+ovarian+cancer.&rft.au=Hartge%2C+P%3BHoover%2C+R%3BMcGowan%2C+L%3BLesher%2C+L%3BNorris%2C+HJ&rft.aulast=Hartge&rft.aufirst=P&rft.date=1988-01-01&rft.volume=127&rft.issue=5&rft.spage=990&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - cancer; epidemiology; risk assessment ER - TY - JOUR T1 - Dense metaphyseal bands and growth arrest associated with isotretinoin therapy. AN - 15052883; 1856647 AB - A 9-year-old boy, treated with high-dose isotretinoin therapy for fibrodysplasia ossificans progressiva, developed dense metaphyseal bands and growth arrest. Discontinuance of isotretinoin therapy was followed by gradual decrease of metaphyseal bands and resumption of clinical growth. The dense metaphyseal bands may be related to the known action of retinoids as modulators of chondrocyte phenotype and gene expression. JF - AM. J. DIS. CHILD. AU - Marini, J C AU - Hill, S AU - Zasloff, MA AD - Hum. Genet. Branch/NICHD, Build. 10, Rm. 8C-429, 9000 Rockville Pike, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 316 EP - 318 VL - 142 IS - 3 SN - 0002-922X, 0002-922X KW - growth KW - case reports KW - isotretinoin KW - Toxicology Abstracts KW - side effects KW - man KW - dermatological agents KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15052883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AM.+J.+DIS.+CHILD.&rft.atitle=Dense+metaphyseal+bands+and+growth+arrest+associated+with+isotretinoin+therapy.&rft.au=Marini%2C+J+C%3BHill%2C+S%3BZasloff%2C+MA&rft.aulast=Marini&rft.aufirst=J&rft.date=1988-01-01&rft.volume=142&rft.issue=3&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=AM.+J.+DIS.+CHILD.&rft.issn=0002922X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - side effects; man; dermatological agents ER - TY - JOUR T1 - Drug purpura due to surreptitious quinidine intake. AN - 15049057; 1856910 AB - Three patients had recurrent episodes of thrombocytopenia that resembled drug purpura, but the drug history in each case did not support the diagnosis. Although the patients specifically denied taking quinidine, serologic testing with this drug was done because the patients had access to it, and it is the commonest cause of drug purpura. Highly specific quinidine-dependent antiplatelet antibodies were found in the sera of all three patients. After being informed of the laboratory findings, the patients have had no recurrences of purpura. Serologic tests for quinidine- or quinine-dependent antibodies can help elucidate some obscure cases of purpura that may be self-induced. JF - Annals of Internal Medicine AU - Reid, D M AU - Shulman, N R AD - Clin. Hematol. Branch, NIDDK, NIH, Build. 10, 8C101, 9000 Rockville Pike, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 206 EP - 208 VL - 108 IS - 2 SN - 0003-4819, 0003-4819 KW - case reports KW - quinidine KW - Toxicology Abstracts KW - side effects KW - antiarrhythmic agents KW - purpura KW - man KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15049057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Internal+Medicine&rft.atitle=Drug+purpura+due+to+surreptitious+quinidine+intake.&rft.au=Reid%2C+D+M%3BShulman%2C+N+R&rft.aulast=Reid&rft.aufirst=D&rft.date=1988-01-01&rft.volume=108&rft.issue=2&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Annals+of+Internal+Medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - side effects; purpura; man; antiarrhythmic agents ER - TY - JOUR T1 - Factitious hypoglycemia due to surreptitious administration of insulin: Diagnosis, treatment, and long-term follow-up. AN - 15048090; 1856678 AB - Ten patients had factitious hypoglycemia due to surreptitious insulin injections diagnosed and were followed for up to 15 years (median, 5 years; range, 2 months to 15 years). When available, demonstration of anti-insulin antibodies was the most helpful diagnostic test. Decreased plasma C-peptide levels corroborated the diagnosis. Young women (nine of ten) with knowledge of the medical profession or relative with diabetes mellitus predominated in the sample. Five of the patients had a history of insulin-requiring diabetes mellitus. Two patients eventually committed suicide. JF - Annals of Internal Medicine AU - Grunberger, G AU - Weiner, J L AU - Silverman, R AU - Taylor, S AU - Gorden, P AD - DPB/DEMD/NIDDK, Westwood 626, Natl. Inst. Health, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 252 EP - 257 VL - 108 IS - 2 SN - 0003-4819, 0003-4819 KW - case reports KW - surreptitious injections KW - insulin KW - Toxicology Abstracts KW - side effects KW - reviews KW - hypoglycemia KW - man KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15048090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Internal+Medicine&rft.atitle=Factitious+hypoglycemia+due+to+surreptitious+administration+of+insulin%3A+Diagnosis%2C+treatment%2C+and+long-term+follow-up.&rft.au=Grunberger%2C+G%3BWeiner%2C+J+L%3BSilverman%2C+R%3BTaylor%2C+S%3BGorden%2C+P&rft.aulast=Grunberger&rft.aufirst=G&rft.date=1988-01-01&rft.volume=108&rft.issue=2&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Annals+of+Internal+Medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - side effects; hypoglycemia; man; reviews ER - TY - JOUR T1 - Induction of rat cytochrome P-450 3 and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl. AN - 15029080; 1836888 AB - Rat cytochrome P-450 3 is a constitutive hepatic steroid hormone 7 alpha -hydroxylase relatively unresponsive to a number of monooxygenase-inducing agents. The present study demonstrates that a polyhalogenated aromatic hydrocarbon inducer, 3,4,5,3',4',5'-hexachlorobiphenyl (HCB), induces P-450 3 in livers of adult male rats, and the increase is the result of an increase in the mRNA for this enzyme. Cytochrome P-450 3 and its mRNA were increased more slowly than cytochrome P-450c and its mRNA, indicating these enzymes are not regulated coordinately in liver. The maximum increase in P-450 3 and P-450 3-dependent androstenedione 7 alpha -hydroxylase activity (2- to 3-fold) occurred 7 days after administration of HCB. JF - Molecular Pharmacology AU - Yeowell, H N AU - Waxman, D J AU - LeBlanc, G A AU - Linko, P AU - Goldstein, JA AD - (B3-02), NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 272 EP - 278 VL - 33 IS - 3 SN - 0026-895X, 0026-895X KW - induction KW - 3,4,5,3',4',5'-hexachlorobiphenyl KW - cytochrome P450 KW - rats KW - Toxicology Abstracts KW - liver KW - X 24190:Polycyclic hydrocarbons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15029080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmacology&rft.atitle=Induction+of+rat+cytochrome+P-450+3+and+its+mRNA+by+3%2C4%2C5%2C3%27%2C4%27%2C5%27-hexachlorobiphenyl.&rft.au=Yeowell%2C+H+N%3BWaxman%2C+D+J%3BLeBlanc%2C+G+A%3BLinko%2C+P%3BGoldstein%2C+JA&rft.aulast=Yeowell&rft.aufirst=H&rft.date=1988-01-01&rft.volume=33&rft.issue=3&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - liver ER - TY - JOUR T1 - Model-building study of the combining sites of two antibodies to alpha (1 arrow right 6)dextran. AN - 15027255; 1838015 AB - Models of the Fv portion (containing the variable regions of the heavy and light chains) of two monoclonal anti- alpha (1 arrow right 6)dextran antibodies, W3129 and 19.1.2, were constructed from amino acid sequences and the known three-dimensional structures of the Fv portions of McPC603 and J539. The modeled combining site of W3129 has a protrusion on one side, formed by the long complementarity-determining region 1 of the light chain and the long complementarity-determining region 3 of the heavy chain, and has a cavity accommodating a glucose moiety. The model of the 19.1.2 site is basically flat with a shallow groove that can accommodate several internal glucose units. These results support the earlier conclusions, from ligand binding data, that W3129 has a cavity-type site, involving the terminal nonreducing glucose residue (endbinder), whereas 19.1.2 has a groove-type. JF - Proceedings of the National Academy of Sciences, USA AU - Padlan, E A AU - Kabat, E A AD - Lab. Mol. Biol., NIDDK, Natl. Inst. Health, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 6885 EP - 6889 VL - 85 IS - 18 SN - 0027-8424, 0027-8424 KW - amino acid sequence KW - antibodies KW - binding sites KW - structural model KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - F 06074:Antigen-antibody interactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15027255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Model-building+study+of+the+combining+sites+of+two+antibodies+to+alpha+%281+arrow+right+6%29dextran.&rft.au=Padlan%2C+E+A%3BKabat%2C+E+A&rft.aulast=Padlan&rft.aufirst=E&rft.date=1988-01-01&rft.volume=85&rft.issue=18&rft.spage=6885&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - amino acid sequence; antibodies ER - TY - JOUR T1 - Carbamate analogues of (-)-physostigmine: In vitro inhibition of acetyl- and butyrylcholinesterase. AN - 15005581; 1813722 AB - Reaction of (-)-eseroline with alkyl, aryl and aralkylisocyanates afforded a series of carbamate analogues of (-)-physostigmine which were assayed for inhibition of acetyl- and butyrylcholinesterase (AChE and BChE, respectively) in vitro. JF - FEBS Letters AU - Yu, Qian-Sheng AU - Atack, J R AU - Rapoport, ST AU - Brossi, A AD - Med. Chem. Sect., Lab. Anal. Chem., NIDDK, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 127 EP - 130 VL - 234 IS - 1 SN - 0014-5793, 0014-5793 KW - acetylcholinesterase KW - activity KW - analogs KW - butyrylcholinesterase KW - inhibition KW - physostigmine KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15005581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Carbamate+analogues+of+%28-%29-physostigmine%3A+In+vitro+inhibition+of+acetyl-+and+butyrylcholinesterase.&rft.au=Yu%2C+Qian-Sheng%3BAtack%2C+J+R%3BRapoport%2C+ST%3BBrossi%2C+A&rft.aulast=Yu&rft.aufirst=Qian-Sheng&rft.date=1988-01-01&rft.volume=234&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Demonstration of residual bone marrow effect in mice exposed to ethylene glycol monomethyl ether. AN - 14998570; 1808243 AB - Ethylene glycol monomethyl ether (EGMME) has been reported to cause hematopoietic abnormalities in man. The authors have shown that mice exposed to EGMME post-natally have suppressed bone marrow cellularity and progenitor cells 8 weeks post-exposure which returns to normal values by 16 weeks. Studies were designed to determine whether EGMME exposed mice that recovered had evidence of residual marrow stem cell injury. The results indicate that EGMME can cause persistent residual damage of bone marrow progenitor cells in mice, an effect that would not be apparent with routine hematological techniques. JF - Toxicology AU - Hong, H L AU - Silver, M AU - Boorman, G A AD - NIEHS (MD C2-02), P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 107 EP - 115 VL - 50 IS - 1 SN - 0300-483X, 0300-483X KW - effects on KW - methyl cellosolve KW - hematopoiesis KW - hematopoietic pathology KW - mice KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - toxicology KW - bone marrow KW - H SE4.20:POISONS AND POISONING KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14998570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Demonstration+of+residual+bone+marrow+effect+in+mice+exposed+to+ethylene+glycol+monomethyl+ether.&rft.au=Hong%2C+H+L%3BSilver%2C+M%3BBoorman%2C+G+A&rft.aulast=Hong&rft.aufirst=H&rft.date=1988-01-01&rft.volume=50&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - bone marrow; mice; toxicology ER - TY - JOUR T1 - The application of immunoassays and fluorometry to the detection of polycyclic hydrocarbon-macromolecular adducts and anti-adduct antibodies in humans. AN - 14966523; 1793824 AB - The metabolic activation of polycyclic aromatic hydrocarbons (PAH) to chemical species that form covalent adducts with cellular macromolecules (DNA and protein) is central to theories of carcinogenesis. Assays are currently being developed that will accurately reflect human macromolecular exposure to these carcinogens. Immunoassays are capable of detecting low levels of PAH-DNA adducts and antibodies directed against these adducts in humans and HPLC/spectrophotofluorimetry allows the detection of carcinogen-DNA or carcinogen-protein adducts in human peripheral blood. Both types of method have inherent advantages and disadvantages, and the use of more than one type of corroborative assay is a feature in this work. JF - International Archives of Occupational and Environmental Health AU - Weston, A AU - Rowe, M AU - Poirier, M AU - Trivers, G AU - Vahakangas, K AU - Newman, M AU - Haugen, A AU - Manchester, D AU - Mann, D AU - Harris, C AD - Lab. Human Carcinog., Div. Cancer Etiol., NCI, Bethesda, MD, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 157 EP - 162 VL - 60 IS - 3 SN - 0340-0131, 0340-0131 KW - pollutant detection KW - radioimmunoassay KW - Health & Safety Science Abstracts; Pollution Abstracts KW - occupational health KW - carcinogenesis KW - polycyclic aromatic hydrocarbons KW - H SI0.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14966523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Archives+of+Occupational+and+Environmental+Health&rft.atitle=The+application+of+immunoassays+and+fluorometry+to+the+detection+of+polycyclic+hydrocarbon-macromolecular+adducts+and+anti-adduct+antibodies+in+humans.&rft.au=Weston%2C+A%3BRowe%2C+M%3BPoirier%2C+M%3BTrivers%2C+G%3BVahakangas%2C+K%3BNewman%2C+M%3BHaugen%2C+A%3BManchester%2C+D%3BMann%2C+D%3BHarris%2C+C&rft.aulast=Weston&rft.aufirst=A&rft.date=1988-01-01&rft.volume=60&rft.issue=3&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=International+Archives+of+Occupational+and+Environmental+Health&rft.issn=03400131&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - polycyclic aromatic hydrocarbons; carcinogenesis; occupational health ER - TY - JOUR T1 - Molecular characterization of gag proteins from simian immunodeficiency virus (SIV sub(Mne)). AN - 14960484; 1780802 AB - The authors report the results of amino acid sequence analysis of several purified proteins from SIV sub(Mne) and also homologous proteins from SIV sub(Mac). These protein sequences are readily aligned with each other and with the predicted amino acid sequences of proteins from SIV sub(Mac) and HIV-2. The results show the genomic origin of the SIV proteins and also reveal some of the proteolytic processing that takes place during viral maturation and thus help to better define the substrate specificities of the viral proteases. In addition, these data can readily be used to predict some cleavage sites in HIV-2 precursor polyproteins. JF - Journal of Virology AU - Henderson, LE AU - Benveniste, R E AU - Sowder, R AU - Copeland, T D AU - Schultz, A M AU - Oroszlan, S AD - Lab. Mol. Virol. and Carcinog., Bionetics Research, Inc., Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 2587 EP - 2595 VL - 62 IS - 8 SN - 0022-538X, 0022-538X KW - amino acid sequence KW - comparison KW - gag gene KW - gene products KW - predictions KW - purification KW - simian immunodeficiency virus KW - structural proteins KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - V 22002:AIDS: Molecular and in vitro aspects KW - V 22032:Viral proteins KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14960484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Molecular+characterization+of+gag+proteins+from+simian+immunodeficiency+virus+%28SIV+sub%28Mne%29%29.&rft.au=Henderson%2C+LE%3BBenveniste%2C+R+E%3BSowder%2C+R%3BCopeland%2C+T+D%3BSchultz%2C+A+M%3BOroszlan%2C+S&rft.aulast=Henderson&rft.aufirst=LE&rft.date=1988-01-01&rft.volume=62&rft.issue=8&rft.spage=2587&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - structural proteins; amino acid sequence; gene products ER - TY - JOUR T1 - The effects of mono-(2-ethylhexyl)-phthalate on rat sertoli cell-enriched primary cultures. AN - 14947116; 1776604 AB - There is evidence from in vivo studies that the Sertoli cell is an initial target cell for the actions of phthalates in the rodent testis. Because this metabolically active cell type plays a central role in spermatogenesis, the authors examined the effects of a toxic phthalate, mono-(2-ethylhexyl)-phthalate (MEHP), on the secretory and synthetic activities of primary testicular cell cultures from 18-day-old rats. These cultures were 78-84% Sertoli cells. Exposure to MEHP decreased cellular ATP by 20%, decreased production of radiolabeled super(14)CO sub(2) from acetate, and decreased media levels of pyruvate, while it increased media levels of lactate and intracellular lipid. Protein synthesis, was not affected by MEHP. Mitochondrial succinate dehydrogenase activity was decreased. Michaelis-Menton kinetic analysis indicated this was a mixed inhibition. There was no change in mitochondrial Rhodamine 123 uptake. JF - Toxicology and Applied Pharmacology AU - Chapin, R E AU - Gray, TJB AU - Phelps, J L AU - Dutton, S L AD - NIEHS, P.O. Box 12233, Mail Drop E2-01, Research Triangle Park, NC 27709, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 467 EP - 479 VL - 92 IS - 3 SN - 0041-008X, 0041-008X KW - effects on KW - mono-(2-ethylhexyl)-phthalate KW - rats KW - Toxicology Abstracts KW - Sertoli cells KW - X 24151:Acute exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14947116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=The+effects+of+mono-%282-ethylhexyl%29-phthalate+on+rat+sertoli+cell-enriched+primary+cultures.&rft.au=Chapin%2C+R+E%3BGray%2C+TJB%3BPhelps%2C+J+L%3BDutton%2C+S+L&rft.aulast=Chapin&rft.aufirst=R&rft.date=1988-01-01&rft.volume=92&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Sertoli cells ER - TY - JOUR T1 - Alcohols stimulate gamma -aminobutyric acid receptor-mediated chloride uptake in brain vesicles: Correlation with intoxication potency. AN - 14929701; 1765210 AB - A series of short-chain alcohols, including ethanol, were examined for their abilities to stimulate gamma -aminobutyric acid (GABA) receptor-mediated chloride uptake into isolated brain vesicles. All of the alcohols tested stimulated super(36)chloride uptake, at concentrations that occur during acute intoxication, and their potencies in stimulating GABA receptor-mediated chloride uptake were highly correlated with both their intoxication potencies in rats and their membrane/buffer partition coefficients. Thus, the activity of alcohols at the GABA receptor-coupled chloride ion channel appears to be related to their ability to enter hydrophobic regions of the neuronal membrane. The data suggest that the anxiolytic, sedative/hypnotic and intoxicating properties of ethanol may, in part, be mediated via an action at central GABA receptors. JF - Brain Research AU - Suzdak, P D AU - Schwartz, R D AU - Skolnick, P AU - Paul, S M AD - Sect. Mol. Pharmacol., Clin. Neurosci. Branch, NIMH, Build. 10, Rm. 4N214, 9000 Rockville Pike, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 340 EP - 345 VL - 444 IS - 2 SN - 0006-8993, 0006-8993 KW - mediation KW - uptake KW - stimulation KW - gamma -aminobutyric acid KW - chloride KW - alcohols KW - brain KW - membrane vesicles KW - Toxicology Abstracts; Biochemistry Abstracts 1: Biological Membranes (till 1993); CSA Neurosciences Abstracts KW - N3 11094:Central nervous system KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14929701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Alcohols+stimulate+gamma+-aminobutyric+acid+receptor-mediated+chloride+uptake+in+brain+vesicles%3A+Correlation+with+intoxication+potency.&rft.au=Suzdak%2C+P+D%3BSchwartz%2C+R+D%3BSkolnick%2C+P%3BPaul%2C+S+M&rft.aulast=Suzdak&rft.aufirst=P&rft.date=1988-01-01&rft.volume=444&rft.issue=2&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - membrane vesicles; brain ER - TY - JOUR T1 - Reproductive toxicity of tricresyl phosphate in a continuous breeding protocol in Swiss (CD-1) mice. AN - 14927762; 1753757 AB - The effects of a mixture of tricresyl phosphate isomers on reproductive performance in Swiss (CD-1) mice were evaluated using a continuous breeding protocol. Tricresyl phosphate (TCP) was mixed into the feed at 0, 0.05, 0.1, and 0.2% by weight. Although the fertility index was not changed in the animals consuming the high-concentration feed, the number of litters per pair decreased in a dose-related fashion, and the proportion of pups born alive, and their weight, was significantly decreased in the high-dose group. A crossover mating trial found impaired fertility in both males and females exposed to 0.2% TCP, with a greater effect in females. Histopathology of the F sub(0) pairs revealed dose-related seminiferous tubule atrophy, and decreased testis and epididymal weights in the high-dose males, while the female reproductive tract showed no histopathologic changes. There were dose-related changes in the adrenals of both sexes, and body weight was depressed in both sexes at the highest concentration. JF - Fundamental and Applied Toxicology AU - Chapin, R E AU - George, J D AU - Lamb, JC IV AD - NIEHS, P.O. Box 12233, Mail Drop E2-01, Research Triangle Park, NC 27709, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 344 EP - 354 VL - 10 IS - 2 SN - 0272-0590, 0272-0590 KW - effects on KW - tritolyl phosphate KW - mice KW - Toxicology Abstracts KW - reproduction KW - teratogenicity KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14927762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+Applied+Toxicology&rft.atitle=Reproductive+toxicity+of+tricresyl+phosphate+in+a+continuous+breeding+protocol+in+Swiss+%28CD-1%29+mice.&rft.au=Chapin%2C+R+E%3BGeorge%2C+J+D%3BLamb%2C+JC+IV&rft.aulast=Chapin&rft.aufirst=R&rft.date=1988-01-01&rft.volume=10&rft.issue=2&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+Applied+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - reproduction; teratogenicity ER - TY - JOUR T1 - The sequence of porcine chromogranin A messenger RNA demonstrates chromogranin A can serve as the precursor for the biologically active hormone, pancreastatin. AN - 14902227; 1754090 AB - Specific oligonucleotide priming of double-stranded DNA has been employed to sequence a porcine chromogranin A adrenomedullary cDNA. Porcine chromogranin A can serve as the precursor for pancreastatin, a polypeptide capable of inhibiting insulin release from the endocrine pancreas and acid secretion from parietal cells of the gut. JF - Endocrinology AU - Iacangelo, AL AU - Fischer-Colbrie, R AU - Koller, K J AU - Brownstein, MJ AU - Eiden, LE AD - Unit. Mol. and Cell. Neurobiol., NIMH, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 2339 EP - 2341 VL - 122 IS - 5 SN - 0013-7227, 0013-7227 KW - amino acid sequence KW - chromogranin A KW - pancreastatin KW - pigs KW - precursors KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - J:20320 KW - N3 11370:GASTRIN AND OTHER GASTROINTESTINAL PEPTIDES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14902227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=The+sequence+of+porcine+chromogranin+A+messenger+RNA+demonstrates+chromogranin+A+can+serve+as+the+precursor+for+the+biologically+active+hormone%2C+pancreastatin.&rft.au=Iacangelo%2C+AL%3BFischer-Colbrie%2C+R%3BKoller%2C+K+J%3BBrownstein%2C+MJ%3BEiden%2C+LE&rft.aulast=Iacangelo&rft.aufirst=AL&rft.date=1988-01-01&rft.volume=122&rft.issue=5&rft.spage=2339&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - amino acid sequence ER - TY - JOUR T1 - Microinjection and expression of an infectious proviral clone and subgenomic envelope construct of a human immunodeficiency virus. AN - 14876781; 1716223 AB - An infectious proviral clone of the human immunodeficiency virus (HIV) was microinjected into the cell nucleus in six cell lines derived from caprine, ovine, bovine, or human solid tissue to study the utility of this method in effecting viral gene expression in nonlymphoid cells. Immunofluorescence assays for HIV demonstrated viral gene expression in only 5% of cells 24-48 h after microinjection; however, no reverse transcriptase activity was detectable, presumably due to a low level of virus release in this limited number of cell. To indirectly assess infectious virus releases, microinjected cells were cocultured with human T4 antigen-positive lymphocytes (H9) sensitive to HIV infection. Syncytia formation, electron microscopy, reverse transcriptase activity, and radioimmunoassay for HIV p24 were used to monitor viral gene expression in cocultures. HIV was efficiently recovered by cocultivating H9 with microinjected cells 48 h after microinjection, regardless of the tissue type or species of origin. JF - AIDS Research and Human Retroviruses AU - Boyd, AL AU - Wood, T G AU - Buckley, A AU - Fischinger, P J AU - Gilden, R V AU - Gonda, MA AD - Lab. Cell and Mol. Struct., Program Resour., Inc., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 31 EP - 41 VL - 4 IS - 1 SN - 0889-2229, 0889-2229 KW - man KW - envelopes KW - gene expression KW - genes KW - helper cells KW - human immunodeficiency virus KW - microinjection KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - V 22050:Viral genetics including virus reactivation KW - V 22002:AIDS: Molecular and in vitro aspects KW - G 07120:Recombinant DNA/Genetic engineering KW - W 30129:Others KW - N 14676:Microinjection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14876781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Research+and+Human+Retroviruses&rft.atitle=Microinjection+and+expression+of+an+infectious+proviral+clone+and+subgenomic+envelope+construct+of+a+human+immunodeficiency+virus.&rft.au=Boyd%2C+AL%3BWood%2C+T+G%3BBuckley%2C+A%3BFischinger%2C+P+J%3BGilden%2C+R+V%3BGonda%2C+MA&rft.aulast=Boyd&rft.aufirst=AL&rft.date=1988-01-01&rft.volume=4&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=AIDS+Research+and+Human+Retroviruses&rft.issn=08892229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - human immunodeficiency virus; envelopes; genes; microinjection; helper cells; gene expression ER - TY - JOUR T1 - Morphological and neurochemical effects of diazepam and phenobarbital on selective culture of neurons from fetal rat brain. AN - 14864009; 1712864 AB - The responses to diazepam (DZ) and phenobarbital (PhB) were studied in enriched neuronal primary cultures from rat embryo hemispheres. It was concluded that both DZ and PhB might affect, at least transiently, the normal growth of neurons in culture. JF - Journal of Neurochemistry AU - Daval, J-L AU - De Vasconcelos, AP AU - Lartaud, I AD - Unit Neurochem., BPB, NIMH, Build. 10, Rm. 3C-210, Bethesda, MD 20892, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 665 EP - 672 VL - 50 IS - 3 SN - 0022-3042, 0022-3042 KW - disruption KW - in vitro KW - diazepam KW - phenobarbital KW - rats KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - neurons KW - brain KW - growth KW - N3 11104:Mammals (except primates) KW - X 24117:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14864009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Morphological+and+neurochemical+effects+of+diazepam+and+phenobarbital+on+selective+culture+of+neurons+from+fetal+rat+brain.&rft.au=Daval%2C+J-L%3BDe+Vasconcelos%2C+AP%3BLartaud%2C+I&rft.aulast=Daval&rft.aufirst=J-L&rft.date=1988-01-01&rft.volume=50&rft.issue=3&rft.spage=665&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - growth; neurons; brain ER - TY - JOUR T1 - The 4-6-8 method of sequence analysis. AN - 14832417; 1693645 AB - A new method to obtain more sequence data from a single gel run is described. This method allows the reading of over 500 bases of sequence data from a single gel by taking advantage of the differential migration of specific sized dideoxy terminated chain lengths in sequencing gels containing variable percentages of acrylamide. JF - Biotechniques AU - Isfort, R J AU - Ihle, J N AD - NCI - Frederick Cancer Res. Facil., BRI - Basic Res. Program, P.O. Box B, Frederick, MD 21701, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 138 EP - 131 VL - 6 IS - 2 SN - 0736-6205, 0736-6205 KW - determination KW - methodology KW - 4-6-8 method KW - DNA KW - nucleotide sequence KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - N 14640:Structure & sequence KW - W 30119:Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14832417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechniques&rft.atitle=The+4-6-8+method+of+sequence+analysis.&rft.au=Isfort%2C+R+J%3BIhle%2C+J+N&rft.aulast=Isfort&rft.aufirst=R&rft.date=1988-01-01&rft.volume=6&rft.issue=2&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Biotechniques&rft.issn=07366205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - DNA; nucleotide sequence ER - TY - JOUR T1 - Waterborne non-A, non-B hepatitis AN - 13788759; 198802266 AB - The incidence of waterborne non-A, non-B hepatitis had been surveyed. The disease was usually mild, except in pregnant women, among whom there was a high fatality rate. Faecal contamination of drinking water was normally implicated in outbreaks of the disease. Hepatitis A and B virus infection could be serologically excluded, and liver biopsy specimens had characteristic histological features. The disease was widespread in India, South-East Asia, and Africa and might occur in Latin America. Clean water supplies and safer excreta disposal were the main control measures. JF - Lancet AU - Ramalingaswami, V AU - Purcell, R H AD - National Institutes of Health, Bethesda, Md. Y1 - 1988 PY - 1988 DA - 1988 SP - 571 EP - 573 IS - 8585 SN - 0099-5355, 0099-5355 KW - Diseases (see also individual groups below) KW - Waterborne KW - Viruses (-general-) (see also individ grps below) KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13788759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Waterborne+non-A%2C+non-B+hepatitis&rft.au=Ramalingaswami%2C+V%3BPurcell%2C+R+H&rft.aulast=Ramalingaswami&rft.aufirst=V&rft.date=1988-01-01&rft.volume=&rft.issue=8585&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=00995355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: General. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Ultrastructural and biochemical studies of intracellular metal-binding patterns in kidney tubule cells of the scallop Placopecten magellanicus following prolonged exposure to cadmium or copper AN - 13766849; S198929770 AB - Scallops in early gametogenesis were exposed to cadmium or copper (20 ug per litre) for 7 weeks. Cadmium had no effect on kidney ultrastructure, but kidneys from copper exposed scallops contained few concentrations and showed marked signs of cellular degeneration characterized by loss of membrane integrity. Ultrastructural changes were associated with reductions in renal isocitrate dehydrogenase activity. Analysis of kidney concentration fractions from cadmium treated scallops showed a 6-fold increase in cadmium concentrations of copper, zinc and manganese, respectively, compared with controls. Analysis of kidney cytosolic metal-binding protein fractions showed 7-fold and 5-fold increases in cadmium and zinc and 50 per cent reductions in copper treated scallops, there was a 5-fold increase in copper and 99, 95 and 76 per cent reductions in cadmium, zinc and manganese. These findings supported the hypothesis that metal induced disruption of the normal homeostatic mechanisms controlling divalent metal cation bioavailability may be an important factor in mediating cell injury. JF - Marine Biology AU - Fowler, BA AU - Gould, E AD - National Institute of Environmental Health Sciences, Research Triangle Park, N.C. Y1 - 1988 PY - 1988 DA - 1988 SP - 207 EP - 216 VL - 97 IS - 2 SN - 0025-3162, 0025-3162 KW - Homeostatically KW - Tubule KW - Aqualine Abstracts KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13766849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Biology&rft.atitle=Ultrastructural+and+biochemical+studies+of+intracellular+metal-binding+patterns+in+kidney+tubule+cells+of+the+scallop+Placopecten+magellanicus+following+prolonged+exposure+to+cadmium+or+copper&rft.au=Fowler%2C+BA%3BGould%2C+E&rft.aulast=Fowler&rft.aufirst=BA&rft.date=1988-01-01&rft.volume=97&rft.issue=2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Marine+Biology&rft.issn=00253162&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Tetanus toxin binds with high affinity to neuroblastoma x glioma hybrid cells NG 108-15 and impairs their stimulated acetylcholine release. AN - 77883033; 2826418 AB - Differentiated neuroblastoma x glioma hybrid cells NG 108-15 express on their surface specific binding sites for tetanus toxin. 450 sites/cell with a KD of 2 x 10(-11) M were found under "physiological" conditions of pH and salt concentrations. A Hill coefficient of 1.1 indicated noncooperative binding. Specific binding of 125I-toxin to its sites could be prevented either by preincubation of the toxin with a neutralizing monoclonal antibody or by pretreatment of the cells with neuraminidase (Vibrio cholerae). To quantify the action of tetanus toxin on the stimulated release of 14C activity from differentiated cells preincubated with [14C]choline, a new type of perfusion device was designed which could be filled with cells growing in monolayers on Cytodex-3 microbeads. Tetanus toxin inhibited the stimulated 14C release in a time- and dose-dependent manner. A greater than 50% inhibition was found after 2 h of incubation with 10(-12) M toxin. The inhibitory action of tetanus toxin could be prevented with a monoclonal antibody to the toxin or with neuraminidase treatment of the cells. These results suggest that the neuraminidase-sensitive 2 x 10(-11) KD receptors are the productive receptors for tetanus intoxication in differentiated NG 108-15 cells. The possible chemical composition of these receptors is discussed. Differentiated NG 108-15 cells provide a useful model in which picomolar tetanus concentrations produce both measurable saturable binding and inhibition of potassium-evoked, acetylcholine release under physiological conditions of pH and salt concentrations. JF - The Journal of biological chemistry AU - Wellhöner, H H AU - Neville, D M AD - Section on Biophysical Chemistry, National Institute of Mental Health, Bethesda, Maryland 20892. Y1 - 1987/12/25/ PY - 1987 DA - 1987 Dec 25 SP - 17374 EP - 17378 VL - 262 IS - 36 SN - 0021-9258, 0021-9258 KW - Tetanus Toxin KW - 0 KW - Bucladesine KW - 63X7MBT2LQ KW - Neuraminidase KW - EC 3.2.1.18 KW - Acetylcholine KW - N9YNS0M02X KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Neuraminidase -- metabolism KW - Glioma -- metabolism KW - Bucladesine -- pharmacology KW - Time Factors KW - Neuroblastoma -- metabolism KW - Hybridomas -- metabolism KW - Acetylcholine -- metabolism KW - Tumor Cells, Cultured -- metabolism KW - Tetanus Toxin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77883033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Tetanus+toxin+binds+with+high+affinity+to+neuroblastoma+x+glioma+hybrid+cells+NG+108-15+and+impairs+their+stimulated+acetylcholine+release.&rft.au=Wellh%C3%B6ner%2C+H+H%3BNeville%2C+D+M&rft.aulast=Wellh%C3%B6ner&rft.aufirst=H&rft.date=1987-12-25&rft.volume=262&rft.issue=36&rft.spage=17374&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-29 N1 - Date created - 1988-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alternative internal splicing in c-myb RNAs occurs commonly in normal and tumor cells. AN - 77974464; 2832149 AB - Activation of the c-myb gene by viral transduction or proviral insertional mutagenesis that is likely to result in the production of structurally altered myb proteins has been shown to be predominantly associated with myelomonocytic tumors. An alternative splicing event in which a portion of the intron bounded by the vE6 and vE7 exons with v-myb homology is included as an additional 363-nucleotide coding exon has recently been identified in a mouse tumor that carries a provirus-activated myb gene. This alternative splicing was hypothesized to be a tumor-specific aberrant form of 3'-myb RNA processing as a consequence of the disruption of upstream 5'-sequences by proviral insertion. However, RNA blot analyses and RNase mapping studies presented here show that a significant portion (approximately 10%) of all myb transcripts examined, whether in normal or in clonal tumor cells, contains the additional exon. Hence the alternative splicing is a hitherto unrecognized common normal event that potentially increases the diversity of the myb proteins expressed in normal tissues including thymus and spleen, as well as in tumor cells with either normal or 5'-rearranged myb alleles. The lack of change in the ratio of the two spliced products expressed from either the normal or the 5'-rearranged myb further indicates that the insertion of the unique 121 amino acids in the larger myb transcripts is not a consequence of tumor-specific activation of the mouse myb oncogene. JF - The EMBO journal AU - Shen-Ong, G L AD - Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/12/20/ PY - 1987 DA - 1987 Dec 20 SP - 4035 EP - 4039 VL - 6 IS - 13 SN - 0261-4189, 0261-4189 KW - RNA, Neoplasm KW - 0 KW - DNA Restriction Enzymes KW - EC 3.1.21.- KW - Index Medicus KW - Animals KW - Reference Values KW - Organ Specificity KW - Mice KW - Gene Expression Regulation KW - Mice, Inbred BALB C KW - Leukemia, Experimental -- genetics KW - Cell Line KW - Cloning, Molecular KW - RNA Splicing KW - Transcription, Genetic KW - RNA, Neoplasm -- genetics KW - Proto-Oncogenes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77974464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+EMBO+journal&rft.atitle=Alternative+internal+splicing+in+c-myb+RNAs+occurs+commonly+in+normal+and+tumor+cells.&rft.au=Shen-Ong%2C+G+L&rft.aulast=Shen-Ong&rft.aufirst=G&rft.date=1987-12-20&rft.volume=6&rft.issue=13&rft.spage=4035&rft.isbn=&rft.btitle=&rft.title=The+EMBO+journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-04 N1 - Date created - 1988-05-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 1982 Jun;2(6):617-24 [14582157] Genes Dev. 1987 May;1(3):287-96 [2445628] Science. 1982 Jun 25;216(4553):1421-3 [6283631] Proc Natl Acad Sci U S A. 1982 Apr;79(7):2194-8 [6954533] Cell. 1982 Dec;31(2 Pt 1):453-63 [6297766] Science. 1983 May 20;220(4599):795-8 [6687762] Nature. 1983 Nov 24-30;306(5941):391-5 [6316155] Nature. 1983 Nov 24-30;306(5941):395-7 [6316156] Science. 1984 Nov 30;226(4678):1077-80 [6093260] Proc Natl Acad Sci U S A. 1985 Oct;82(19):6687-91 [2995979] EMBO J. 1985 Aug;4(8):2003-8 [2998780] Proc Natl Acad Sci U S A. 1986 May;83(10):3204-8 [3010282] Proc Natl Acad Sci U S A. 1986 Jul;83(13):4685-9 [3088565] Annu Rev Biochem. 1986;55:1091-117 [3017190] Annu Rev Biochem. 1986;55:1119-50 [2943217] Mol Cell Biol. 1986 Feb;6(2):380-92 [3023843] Proc Natl Acad Sci U S A. 1987 Jan;84(1):199-203 [3025854] Cell. 1987 Jan 30;48(2):177-8 [2948653] Annu Rev Genet. 1986;20:361-84 [3028245] Proc Natl Acad Sci U S A. 1987 May;84(10):3171-5 [3033638] J Virol. 1987 Jul;61(7):2339-43 [2884332] Science. 1987 Jul 24;237(4813):411-5 [2440106] EMBO J. 1987 Jun;6(6):1643-51 [3608990] EMBO J. 1987 Jul;6(7):2027-35 [2958276] EMBO J. 1987 Jul;6(7):2037-44 [2958277] Science. 1973 Nov 9;182(4112):592-4 [4355680] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Modulation by palmitoylcarnitine of protein kinase C activation. AN - 81108580; 3479247 AB - Palmitoylcarnitine, a reported protein kinase C inhibitor, enhanced the phorbol ester dependency of the enzyme, augmenting protein kinase C activity in the presence of phorbol esters such as phorbol 12,13-dibutyrate while inhibiting the basal activity measured in the presence of calcium plus phosphatidylserine. Weakly potent phorbol esters such as phorbol 12,13-diacetate and 4-O-methylphorbol 12-myristate 13-acetate were full agonists like phorbol 12,13-dibutyrate for activation of protein kinase C in the presence of palmitoylcarnitine. On the other hand, 1,2-diacylglycerols such as 1,2-diolein were only partially stimulatory. Palmitoylcarnitine did not interfere with the association of protein kinase C with phosphatidylserine, suggesting that its action was on protein kinase C activation per se rather than on priming. A long fatty acid ester, quaternary amine, and anionic charge were needed for the palmitoylcarnitine-like action. Phosphatidylcholine, which possesses these features, partially mimicked the action of palmitoylcarnitine. Palmitoylcarnitine thus appears to be a lipophilic modulator of protein kinase C rather than a simple inhibitor. The results raise the possibility that differences in response between phorbol esters and diacylglycerols may reflect differential ability to activate protein kinase C in the appropriate lipid environment rather than the existence of unique targets for one or the other compound. JF - Cancer research AU - Nakadate, T AU - Blumberg, P M AD - Molecular Mechanisms of Tumor Promotion Section, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/12/15/ PY - 1987 DA - 1987 Dec 15 SP - 6537 EP - 6542 VL - 47 IS - 24 Pt 1 SN - 0008-5472, 0008-5472 KW - Diglycerides KW - 0 KW - Histones KW - Phorbol Esters KW - Phospholipids KW - Palmitoylcarnitine KW - 1935-18-8 KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Carnitine KW - S7UI8SM58A KW - Calcium KW - SY7Q814VUP KW - diolein KW - Z3MP1W91CW KW - Index Medicus KW - Calcium -- metabolism KW - Phorbol Esters -- pharmacology KW - Animals KW - Diglycerides -- pharmacology KW - Histones -- metabolism KW - Phospholipids -- metabolism KW - Enzyme Activation -- drug effects KW - Mice KW - Protein Kinase C -- metabolism KW - Palmitoylcarnitine -- pharmacology KW - Carnitine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81108580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Modulation+by+palmitoylcarnitine+of+protein+kinase+C+activation.&rft.au=Nakadate%2C+T%3BBlumberg%2C+P+M&rft.aulast=Nakadate&rft.aufirst=T&rft.date=1987-12-15&rft.volume=47&rft.issue=24+Pt+1&rft.spage=6537&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-21 N1 - Date created - 1988-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Heterogeneous DNA damage and repair in the mammalian genome. AN - 81106274; 3315187 JF - Cancer research AU - Bohr, V A AU - Phillips, D H AU - Hanawalt, P C AD - Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/12/15/ PY - 1987 DA - 1987 Dec 15 SP - 6426 EP - 6436 VL - 47 IS - 24 Pt 1 SN - 0008-5472, 0008-5472 KW - Alkylating Agents KW - 0 KW - Carcinogens KW - Chromatin KW - DNA, Mitochondrial KW - Tetrahydrofolate Dehydrogenase KW - EC 1.5.1.3 KW - Index Medicus KW - Carcinogens -- pharmacology KW - Animals KW - DNA, Mitochondrial -- drug effects KW - Oncogenes KW - Humans KW - Alkylating Agents -- pharmacology KW - Chromatin -- drug effects KW - Transcription, Genetic KW - Repetitive Sequences, Nucleic Acid -- drug effects KW - Proto-Oncogenes KW - Nucleic Acid Conformation KW - Tetrahydrofolate Dehydrogenase -- genetics KW - Alkylation KW - DNA Repair KW - DNA Damage KW - Mammals -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81106274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Heterogeneous+DNA+damage+and+repair+in+the+mammalian+genome.&rft.au=Bohr%2C+V+A%3BPhillips%2C+D+H%3BHanawalt%2C+P+C&rft.aulast=Bohr&rft.aufirst=V&rft.date=1987-12-15&rft.volume=47&rft.issue=24+Pt+1&rft.spage=6426&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-21 N1 - Date created - 1988-01-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Cancer Res 1988 Mar 1;48(5):1377 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A Taq I polymorphism in the human P450IIE1 gene on chromosome 10 (CYP2E). AN - 77895502; 2892165 JF - Nucleic acids research AU - McBride, O W AU - Umeno, M AU - Gelboin, H V AU - Gonzalez, F J AD - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/12/10/ PY - 1987 DA - 1987 Dec 10 SP - 10071 VL - 15 IS - 23 SN - 0305-1048, 0305-1048 KW - DNA Restriction Enzymes KW - EC 3.1.21.- KW - Deoxyribonucleases, Type II Site-Specific KW - EC 3.1.21.4 KW - TCGA-specific type II deoxyribonucleases KW - Index Medicus KW - Genes KW - Humans KW - Polymorphism, Restriction Fragment Length KW - Polymorphism, Genetic KW - Chromosomes, Human, Pair 10 KW - Chromosome Mapping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77895502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=A+Taq+I+polymorphism+in+the+human+P450IIE1+gene+on+chromosome+10+%28CYP2E%29.&rft.au=McBride%2C+O+W%3BUmeno%2C+M%3BGelboin%2C+H+V%3BGonzalez%2C+F+J&rft.aulast=McBride&rft.aufirst=O&rft.date=1987-12-10&rft.volume=15&rft.issue=23&rft.spage=10071&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1986 Dec 15;261(35):16689-97 [3782137] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - cDNA and amino acid sequences of two members of the human P450IIC gene subfamily. AN - 77882360; 3697070 JF - Nucleic acids research AU - Kimura, S AU - Pastewka, J AU - Gelboin, H V AU - Gonzalez, F J AD - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/12/10/ PY - 1987 DA - 1987 Dec 10 SP - 10053 EP - 10054 VL - 15 IS - 23 SN - 0305-1048, 0305-1048 KW - DNA KW - 9007-49-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Base Sequence KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Cloning, Molecular KW - DNA -- isolation & purification KW - Cytochrome P-450 Enzyme System -- genetics KW - Cytochrome P-450 Enzyme System -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77882360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=cDNA+and+amino+acid+sequences+of+two+members+of+the+human+P450IIC+gene+subfamily.&rft.au=Kimura%2C+S%3BPastewka%2C+J%3BGelboin%2C+H+V%3BGonzalez%2C+F+J&rft.aulast=Kimura&rft.aufirst=S&rft.date=1987-12-10&rft.volume=15&rft.issue=23&rft.spage=10053&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] Proc Natl Acad Sci U S A. 1983 Mar;80(5):1194-8 [6219389] Biochemistry. 1987 Feb 24;26(4):1094-9 [3032244] J Biol Chem. 1986 Aug 15;261(23):10667-72 [3015936] DNA. 1987 Feb;6(1):1-11 [3829886] Anal Biochem. 1983 Feb 15;129(1):216-23 [6305233] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Temporal separation of protein toxin translocation from processing events. AN - 77823647; 3680260 AB - Intoxication of Vero cells by ricin, modeccin, diphtheria toxin (DT), and Pseudomonas exotoxin A requires: 1) binding to cell surface receptors; 2) transport to the cytoplasm; and 3) enzymatic inactivation of a component of the protein synthetic machinery. The kinetic profiles of all four toxins consist of a lag followed by the apparent first-order decrease in protein synthesis. Autoradiographic analysis of DT-intoxicated cell populations has demonstrated that two subpopulations of cells exist during the period of decreasing protein synthesis: one population synthesizing at control levels and the other synthesizing little or no protein (Hudson, T. H., and Neville, D. M., Jr. (1985) J. Biol. Chem. 260, 2675-2680). The present study correlates the autoradiographic data with the rates of protein synthesis decline in cells intoxicated with modeccin, ricin, Pseudomonas exotoxin A, as well DT. In all cases, the first time point which exhibits a decrease in protein synthetic activity also exhibits two subpopulations of cells, one synthesizing protein at control rates and the other synthesizing little or no protein. As the intoxication progresses, cells leave the control population by the rapid cessation of all protein synthesis. These experiments demonstrate that transport of all four toxins to the cytosol is the rate-limiting step during the pseudo first-order decline in protein synthesis. Furthermore, the final step in the transport process (translocation) must result in the release to the cytoplasm of a quantity of toxin sufficient to rapidly inactivate all protein synthesis in that cell. The probability of a translocation event occurring in any cell of the population is established during the lag and remains constant throughout the first-order decrease in protein synthesis. The requirement for acidification during the intoxication by DT, Pseudomonas exotoxin A, or modeccin is restricted to the lag period. Acidification is therefore necessary to establish the probability of translocation, but it is not directly involved in the actual translocation of these toxins. The pseudo first-order passage of DT intoxications through antitoxin and NH4Cl- or monensin-sensitive stages are shown to have the same cellular basis as the pseudo first-order decrease in protein synthesis. A kinetic model is presented which defines the DT intoxication process from one of its earliest events (endocytosis) to its penultimate event (translocation of toxin to the cytosol).(ABSTRACT TRUNCATED AT 400 WORDS) JF - The Journal of biological chemistry AU - Hudson, T H AU - Neville, D M AD - Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, Maryland 20892. Y1 - 1987/12/05/ PY - 1987 DA - 1987 Dec 05 SP - 16484 EP - 16494 VL - 262 IS - 34 SN - 0021-9258, 0021-9258 KW - Bacterial Toxins KW - 0 KW - Diphtheria Toxin KW - Exotoxins KW - Lectins KW - Plant Lectins KW - Ribosome Inactivating Proteins, Type 2 KW - Virulence Factors KW - Ammonium Chloride KW - 01Q9PC255D KW - modeccin KW - 65988-88-7 KW - Ricin KW - 9009-86-3 KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Index Medicus KW - Cytosol -- metabolism KW - Animals KW - Kinetics KW - Hydrogen-Ion Concentration KW - Cercopithecus aethiops KW - Biological Transport, Active KW - Ammonium Chloride -- pharmacology KW - Time Factors KW - Cell Line KW - Lectins -- pharmacokinetics KW - Ricin -- pharmacokinetics KW - Diphtheria Toxin -- pharmacokinetics KW - Exotoxins -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77823647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Temporal+separation+of+protein+toxin+translocation+from+processing+events.&rft.au=Hudson%2C+T+H%3BNeville%2C+D+M&rft.aulast=Hudson&rft.aufirst=T&rft.date=1987-12-05&rft.volume=262&rft.issue=34&rft.spage=16484&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-12 N1 - Date created - 1988-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene. AN - 77843994; 3500513 AB - The epidermal growth factor (EGF) receptor gene EGFR has been placed in a retrovirus vector to examine the growth properties of cells that experimentally overproduce a full-length EGF receptor. NIH 3T3 cells transfected with the viral DNA or infected with the corresponding rescued retrovirus developed a fully transformed phenotype in vitro that required both functional EGFR expression and the presence of EGF in the growth medium. Cells expressing 4 x 10(5) EGF receptors formed tumors in nude mice, while control cells did not. Therefore, the EGFR retrovirus, which had a titer on NIH 3T3 cells that was greater than 10(7) focus-forming units per milliliter, can efficiently transfer and express this gene, and increased numbers of EGF receptors can contribute to the transformed phenotype. JF - Science (New York, N.Y.) AU - Velu, T J AU - Beguinot, L AU - Vass, W C AU - Willingham, M C AU - Merlino, G T AU - Pastan, I AU - Lowy, D R AD - Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/12/04/ PY - 1987 DA - 1987 Dec 04 SP - 1408 EP - 1410 VL - 238 IS - 4832 SN - 0036-8075, 0036-8075 KW - DNA, Recombinant KW - 0 KW - Recombinant Proteins KW - Epidermal Growth Factor KW - 62229-50-9 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Animals KW - Fibroblasts -- pathology KW - Neoplasms, Experimental -- etiology KW - Cells, Cultured KW - Humans KW - Genetic Vectors KW - Harvey murine sarcoma virus -- genetics KW - Mice, Nude KW - Mice KW - Recombinant Proteins -- genetics KW - Male KW - Receptor, Epidermal Growth Factor -- drug effects KW - Receptor, Epidermal Growth Factor -- genetics KW - Cell Transformation, Neoplastic -- chemically induced KW - Epidermal Growth Factor -- pharmacology KW - Proto-Oncogenes KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77843994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Epidermal-growth-factor-dependent+transformation+by+a+human+EGF+receptor+proto-oncogene.&rft.au=Velu%2C+T+J%3BBeguinot%2C+L%3BVass%2C+W+C%3BWillingham%2C+M+C%3BMerlino%2C+G+T%3BPastan%2C+I%3BLowy%2C+D+R&rft.aulast=Velu&rft.aufirst=T&rft.date=1987-12-04&rft.volume=238&rft.issue=4832&rft.spage=1408&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-06 N1 - Date created - 1988-01-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alterations in local cerebral glucose utilization induced by phencyclidine. AN - 85231058; pmid-3427457 AB - The effects of phencyclidine (PCP; 0.5, 1,5, 10 mg/kg, i.v.) on local cerebral glucose utilization (LCGU) in the rat were studied with the 2-deoxy-D-[1-14C]glucose method. Significant findings were obtained in 41 of 87 brain regions of PCP-treated rats (25-270% of control). Rates of LCGU increased throughout the limbic system, except the habenula. Although LCGU increased in most sensory structures, it decreased in specific layers of the somatosensory and auditory cortices and the inferior colliculus. Evidence was seen for dissociation between LCGU responses of specific thalamic relay areas and their terminal fields in the cortex. Increases in LCGU occurred throughout the motor system, manifesting a striking pattern of columnar activity in the motor cortex. However, LCGU was reduced in the frontal cortical pole. Elevated LCGU was observed in the pontine nuclei and the nuclei and the nucleus solitarius. Effects of 5 mg/kg PCP diminished with time although 8 regions maintained a metabolic alteration at 180 min. PCP induced several behaviors, including stereotypies, which varied with the dose and time after drug administration. The results demonstrate a PCP-induced activation of various functional circuits in the brain, especially the limbic system, and may provide a physiological basis for PCP's psychotomimetic properties. JF - Brain Research AU - Weissman, A D AU - Dam, M AU - London, E D AD - Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224. PY - 1987 SP - 29 EP - 40 VL - 435 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Carbon Radioisotopes KW - Blood Pressure KW - Animal KW - Brain KW - Organ Specificity KW - Deoxy Sugars KW - Autoradiography KW - Rats KW - Rats, Inbred F344 KW - Phencyclidine KW - Kinetics KW - Deoxyglucose KW - Pulse KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85231058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Alterations+in+local+cerebral+glucose+utilization+induced+by+phencyclidine.&rft.au=Weissman%2C+A+D%3BDam%2C+M%3BLondon%2C+E+D&rft.aulast=Weissman&rft.aufirst=A&rft.date=1987-12-01&rft.volume=435&rft.issue=1-2&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Mouse keratinocytes derived from initiated skin or papillomas are resistant to DNA strand breakage by benzoyl peroxide: a possible mechanism for tumor promotion mediated by benzoyl peroxide. AN - 81113529; 2445498 AB - Alkaline elution was used to examine DNA single-strand breaks in cultured normal and carcinogen-altered mouse keratinocytes exposed to 12-O-tetradecanoyl phorbol-13-acetate and benzoyl peroxide. Seven cell lines derived from carcinogen-induced mouse skin papillomas and three cell lines derived from N-methyl-N'-nitro-N-nitrosoguanidine-treated non-tumor bearing mouse skin were resistant to phorbol ester-mediated DNA strand breaks after 6 or 24 h. Normal keratinocytes sustained strand breaks after 24 h but not after 6 h. Benzoyl peroxide induced extensive strand breaks in normal keratinocytes at both 6 and 24 h, and this was associated with marked cytotoxicity. In contrast, 9 of 10 cell lines showed complete or partial resistance to strand breaks following benzoyl peroxide exposure. It is proposed that differential resistance to DNA strand breaks and cytotoxicity among normal and carcinogen-altered keratinocytes provides the biological basis for the promoting action of benzoyl peroxide. Furthermore, sublethal DNA damage in preneoplastic or neoplastic keratinocytes may account for the potency of benzoyl peroxide in causing malignant conversion. JF - Carcinogenesis AU - Hartley, J A AU - Gibson, N W AU - Kilkenny, A AU - Yuspa, S H AD - Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1827 EP - 1830 VL - 8 IS - 12 SN - 0143-3334, 0143-3334 KW - Peroxides KW - 0 KW - Methylnitronitrosoguanidine KW - 12H3O2UGSF KW - Keratins KW - 68238-35-7 KW - Benzoyl Peroxide KW - W9WZN9A0GM KW - Index Medicus KW - Animals KW - Mice KW - Mice, Inbred BALB C KW - Skin Neoplasms -- genetics KW - Skin -- drug effects KW - Skin Neoplasms -- chemically induced KW - Skin -- cytology KW - Papilloma -- genetics KW - Papilloma -- chemically induced KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81113529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Mouse+keratinocytes+derived+from+initiated+skin+or+papillomas+are+resistant+to+DNA+strand+breakage+by+benzoyl+peroxide%3A+a+possible+mechanism+for+tumor+promotion+mediated+by+benzoyl+peroxide.&rft.au=Hartley%2C+J+A%3BGibson%2C+N+W%3BKilkenny%2C+A%3BYuspa%2C+S+H&rft.aulast=Hartley&rft.aufirst=J&rft.date=1987-12-01&rft.volume=8&rft.issue=12&rft.spage=1827&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-05 N1 - Date created - 1988-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increased fragile sites and sister chromatid exchanges in bone marrow and peripheral blood of young cigarette smokers. AN - 81111055; 3677077 AB - Cigarette smoking is considered to be the single most important acquired cause of cancer mortality. Studies of chromosome aberrations, sister chromatid exchanges, and fragile sites in peripheral blood or bone marrow are useful methods to detect the effects of the environmental mutagens or carcinogens found in cigarette smoke. The effects of smoking on the immature cells in the bone marrow have not been studied. Here, we examine the peripheral blood and bone marrow in 18 smokers (15 females and 3 males) with a median age of 25 years (range, 21-40) and an average cigarette use corresponding to 6 pack years. In both bone marrow cells and peripheral blood lymphocytes, we were able to show a significantly increased frequency of sister chromatid exchanges in smokers with a 5 or more cigarette pack year history, but not in those who smoked less than 5 pack years. We also found a higher frequency of sister chromatid exchanges in peripheral blood lymphocytes than in bone marrow cells. In addition, the peripheral lymphocytes of smokers demonstrated (a) a significantly higher frequency of fragile sites, (b) an increased number of metaphases with extensive breakage; and (c) elevated expression of fragile sites at the cancer breakpoints 3p14.2, 11q13.3, 22q12.2, and 11p13-p14.2 and at the oncogene sites bcl 1, erb B, erb A, and sis. Our results suggest that chromosomal DNA of peripheral blood lymphocytes is sensitive to cigarette smoking. Studies of the chromosomal changes in these cells provide an index of the mutagenic damage caused by these exogenous agents in individual patients and the ability of individuals to repair that damage, and might predict susceptibility to malignant events. JF - Cancer research AU - Kao-Shan, C S AU - Fine, R L AU - Whang-Peng, J AU - Lee, E C AU - Chabner, B A AD - Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/12/01/ PY - 1987 DA - 1987 Dec 01 SP - 6278 EP - 6282 VL - 47 IS - 23 SN - 0008-5472, 0008-5472 KW - Index Medicus KW - Age Factors KW - Humans KW - Adult KW - Chromosome Aberrations KW - Male KW - Female KW - Bone Marrow Cells KW - Smoking KW - Sister Chromatid Exchange KW - Blood Cells -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81111055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Increased+fragile+sites+and+sister+chromatid+exchanges+in+bone+marrow+and+peripheral+blood+of+young+cigarette+smokers.&rft.au=Kao-Shan%2C+C+S%3BFine%2C+R+L%3BWhang-Peng%2C+J%3BLee%2C+E+C%3BChabner%2C+B+A&rft.aulast=Kao-Shan&rft.aufirst=C&rft.date=1987-12-01&rft.volume=47&rft.issue=23&rft.spage=6278&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-05 N1 - Date created - 1988-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential regulation of c-Ha-ras and c-Ki-ras gene expression in rat mammary gland. AN - 81110424; 2824087 AB - Steady-state levels of c-Has-ras and c-Ki-ras RNA in gestating and lactating rat mammary gland were measured. The c-Ha-ras-specific RNA level increased during gestation and declined with the onset of lactation. On the contrary, the level of c-Ki-ras RNA remained unchanged both during gestation and lactation. There was no change in the level of ras-transcripts in either growing or regressing 7,12-dimethylbenz[a]anthracene-induced mammary tumors. Intravenous infusion of prolactin or implantation of pituitary-derived tumor, which secretes mammotropic hormone, in virgin female rats resulted in decreased levels of c-Ha-ras RNA and no change in c-Ki-ras RNA levels. Our results suggest the transcription of c-Ha-ras and c-Ki-ras genes is differentially regulated. JF - Carcinogenesis AU - Nieto, A AU - Qasba, P K AU - Nakhasi, H L AU - Dhar, R AD - Laboratory of Molecular Virology, NCI. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1955 EP - 1958 VL - 8 IS - 12 SN - 0143-3334, 0143-3334 KW - RNA, Neoplasm KW - 0 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - DNA Restriction Enzymes KW - EC 3.1.21.- KW - Deoxyribonuclease HindIII KW - Index Medicus KW - Rats KW - Animals KW - DNA Restriction Enzymes -- metabolism KW - Mammary Neoplasms, Experimental -- genetics KW - RNA, Neoplasm -- analysis KW - Female KW - Pregnancy KW - Lactation KW - Mammary Glands, Animal -- analysis KW - Oncogenes KW - Gene Expression Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81110424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Differential+regulation+of+c-Ha-ras+and+c-Ki-ras+gene+expression+in+rat+mammary+gland.&rft.au=Nieto%2C+A%3BQasba%2C+P+K%3BNakhasi%2C+H+L%3BDhar%2C+R&rft.aulast=Nieto&rft.aufirst=A&rft.date=1987-12-01&rft.volume=8&rft.issue=12&rft.spage=1955&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-05 N1 - Date created - 1988-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of the rasH oncogene and its p21 product in chemically induced skin tumors and tumor-derived cell lines. AN - 81109734; 2824083 AB - Mouse skin papillomas and squamous cell carcinomas induced by initiation with 7,12-dimethylbenz[a]anthracene and promotion with phorbol esters, such as 12-O-tetradecanoyl phorbol-13-acetate, frequently contain an activated Harvey ras gene. Six murine epidermal cells lines established from pooled skin papillomas previously tested negative in the NIH-3T3 assay, but have an altered differentiation program by a variety of criteria. The Harvey ras gene and its p21 protein product from these cell lines have been analyzed for alterations responsible for their altered growth and differentiation properties that were undetectable by 3T3 transfection assays. In comparison with primary papillomas and carcinomas, shown to have a point mutation in codon 61 of the Harvey ras gene, resulting in a p21 product with the diagnostic alteration in SDS-PAGE, the papilloma cell lines exhibited neither the codon 61 mutation, nor p21 product with altered migration in SDS-PAGE. These findings suggest that these papilloma cell lines contain a genetic lesion(s), other than Harvey ras activation, that may be responsible for their altered epithelial differentiation patterns and thus may serve as a useful model for identifying lesions involved in malignant conversion. JF - Carcinogenesis AU - Harper, J R AU - Reynolds, S H AU - Greenhalgh, D A AU - Strickland, J E AU - Lacal, J C AU - Yuspa, S H AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1821 EP - 1825 VL - 8 IS - 12 SN - 0143-3334, 0143-3334 KW - DNA, Neoplasm KW - 0 KW - Proto-Oncogene Proteins KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - DNA Restriction Enzymes KW - EC 3.1.21.- KW - endodeoxyribonuclease XBAI KW - Deoxyribonucleases, Type II Site-Specific KW - EC 3.1.21.4 KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Papilloma -- analysis KW - Polymorphism, Genetic KW - Carcinoma, Squamous Cell -- chemically induced KW - Mice KW - Papilloma -- genetics KW - Carcinoma, Squamous Cell -- analysis KW - DNA Restriction Enzymes -- metabolism KW - Transfection KW - Carcinoma, Squamous Cell -- genetics KW - Papilloma -- chemically induced KW - Cell Line KW - Female KW - Skin Neoplasms -- genetics KW - Oncogenes KW - Proto-Oncogene Proteins -- analysis KW - Skin Neoplasms -- chemically induced KW - Skin Neoplasms -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81109734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Analysis+of+the+rasH+oncogene+and+its+p21+product+in+chemically+induced+skin+tumors+and+tumor-derived+cell+lines.&rft.au=Harper%2C+J+R%3BReynolds%2C+S+H%3BGreenhalgh%2C+D+A%3BStrickland%2C+J+E%3BLacal%2C+J+C%3BYuspa%2C+S+H&rft.aulast=Harper&rft.aufirst=J&rft.date=1987-12-01&rft.volume=8&rft.issue=12&rft.spage=1821&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-05 N1 - Date created - 1988-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of production of transforming growth factor-beta and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines. AN - 81107670; 3479241 AB - Steady state mRNA levels for transforming growth factor beta, platelet-derived growth factor (PDGF) A-chain, and PDGF B-chain were measured in normal human mesothelial cells, SV40 large T-antigen expressing human mesothelial cells, and human mesothelioma cell lines. The mRNA expression level for transforming growth factor beta was similar in all three types of culture while normal human mesothelial cells secrete more transforming growth factor beta than do mesothelioma cell lines or T-antigen expressing mesothelial cells. In contrast, both PDGF A- and B-chain mRNAs are expressed at higher levels in mesothelioma cell lines than in normal human mesothelial cells. PDGF-like mitogenic activity was readily detectable in medium conditioned by a mesothelioma cell line and was undetectable in conditioned medium from normal cells. These results suggest the hypothesis that PDGF may be an autocrine growth factor in mesothelioma. JF - Cancer research AU - Gerwin, B I AU - Lechner, J F AU - Reddel, R R AU - Roberts, A B AU - Robbins, K C AU - Gabrielson, E W AU - Harris, C C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/12/01/ PY - 1987 DA - 1987 Dec 01 SP - 6180 EP - 6184 VL - 47 IS - 23 SN - 0008-5472, 0008-5472 KW - Culture Media KW - 0 KW - Peptides KW - Platelet-Derived Growth Factor KW - RNA, Messenger KW - Transforming Growth Factors KW - 76057-06-2 KW - Index Medicus KW - RNA, Messenger -- metabolism KW - Mitosis KW - Humans KW - Gene Expression Regulation KW - Epithelium -- metabolism KW - Peptides -- genetics KW - Cell Line KW - Peptide Biosynthesis KW - Mesothelioma -- metabolism KW - Platelet-Derived Growth Factor -- genetics KW - Pleura -- metabolism KW - Platelet-Derived Growth Factor -- biosynthesis KW - Pleura -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81107670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Comparison+of+production+of+transforming+growth+factor-beta+and+platelet-derived+growth+factor+by+normal+human+mesothelial+cells+and+mesothelioma+cell+lines.&rft.au=Gerwin%2C+B+I%3BLechner%2C+J+F%3BReddel%2C+R+R%3BRoberts%2C+A+B%3BRobbins%2C+K+C%3BGabrielson%2C+E+W%3BHarris%2C+C+C&rft.aulast=Gerwin&rft.aufirst=B&rft.date=1987-12-01&rft.volume=47&rft.issue=23&rft.spage=6180&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-05 N1 - Date created - 1988-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Plasma hyperosmolality increases G protein and 3',5'-cyclic adenosine monophosphate synthesis in the paraventricular and supraoptic nuclei. AN - 78067310; 2856404 AB - Hyperosmotic stimuli produce profound changes in cellular morphology and biosynthetic activities within the hypothalamic paraventricular and supraoptic nuclei (SON) of the rat. The mechanisms by which osmoreceptive signals are transduced within these nuclei are poorly understood. We examined several components of the cAMP-associated second messenger system after giving rats 2% saline to drink for one week, a strong hyperosmotic stimulus. We found that mRNA levels for both the stimulatory and inhibitory guanine-nucleotide binding protein alpha-subunits were increased in the paraventricular nucleus and SON. In the SON, these changes were accompanied by increased basal cAMP levels, cholera toxin-stimulated adenylate cyclase, and Gs alpha. Our results suggest that Gs alpha levels are not saturated with respect to adenylate cyclase coupling and that osmoreception activates the cAMP second messenger system. JF - Molecular endocrinology (Baltimore, Md.) AU - Young, W S AU - Shepard, E A AU - Burch, R M AD - Laboratory of Cell Biology, National Institute of Mental Health Bethesda, Maryland 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 884 EP - 888 VL - 1 IS - 12 SN - 0888-8809, 0888-8809 KW - Oligonucleotide Probes KW - 0 KW - RNA, Messenger KW - Adenosine Diphosphate Ribose KW - 20762-30-5 KW - Cholera Toxin KW - 9012-63-9 KW - Cyclic AMP KW - E0399OZS9N KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Osmolar Concentration KW - Animals KW - Cholera Toxin -- pharmacology KW - Adenylyl Cyclases -- metabolism KW - Nucleic Acid Hybridization KW - RNA, Messenger -- genetics KW - Adenosine Diphosphate Ribose -- metabolism KW - Male KW - Catalysis KW - Plasma -- physiology KW - Paraventricular Hypothalamic Nucleus -- metabolism KW - Cyclic AMP -- biosynthesis KW - GTP-Binding Proteins -- biosynthesis KW - Supraoptic Nucleus -- metabolism KW - Cyclic AMP -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78067310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Plasma+hyperosmolality+increases+G+protein+and+3%27%2C5%27-cyclic+adenosine+monophosphate+synthesis+in+the+paraventricular+and+supraoptic+nuclei.&rft.au=Young%2C+W+S%3BShepard%2C+E+A%3BBurch%2C+R+M&rft.aulast=Young&rft.aufirst=W&rft.date=1987-12-01&rft.volume=1&rft.issue=12&rft.spage=884&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-05 N1 - Date created - 1990-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Testicular cancer in young men: the search for causes of the epidemic increase in the United States. AN - 78045176; 2901454 AB - A case-control study of 271 men with testicular cancer and 259 controls was conducted in the Washington, DC area to evaluate whether suggested risk factors could be responsible for the epidemic increases in testicular cancer in young men. No substantial risks were associated with a history of groin hernia operation, the common childhood diseases, allergies, x rays below the waist, venereal disease, vasectomy, or external means of elevating the temperature of the testis. Excess risks were associated with a history of undescended testis (RR = 3.7, CI = 1.5-9.5), testicular trauma (RR = 2.6, CI = 1.6-4.2), and mumps orchitis (RR = 5.8, CI = 0.7-129.7). It is unlikely, however, that any of these conditions has increased sufficiently over time to markedly affect the testicular cancer incidence patterns. Therefore, while the risk factors identified in this paper are of epidemiological interest, they do not account for the increase in testicular cancer in young men. JF - Journal of epidemiology and community health AU - Brown, L M AU - Pottern, L M AU - Hoover, R N AD - Epidemiology and Biostatics Program, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 349 EP - 354 VL - 41 IS - 4 SN - 0143-005X, 0143-005X KW - Index Medicus KW - District of Columbia KW - Cryptorchidism -- complications KW - Testis -- injuries KW - Risk Factors KW - Humans KW - Testis -- pathology KW - Adult KW - Smoking -- adverse effects KW - Clothing -- adverse effects KW - Maryland KW - Adolescent KW - Male KW - Testicular Neoplasms -- pathology KW - Testicular Neoplasms -- etiology KW - Testicular Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78045176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+epidemiology+and+community+health&rft.atitle=Testicular+cancer+in+young+men%3A+the+search+for+causes+of+the+epidemic+increase+in+the+United+States.&rft.au=Brown%2C+L+M%3BPottern%2C+L+M%3BHoover%2C+R+N&rft.aulast=Brown&rft.aufirst=L&rft.date=1987-12-01&rft.volume=41&rft.issue=4&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Journal+of+epidemiology+and+community+health&rft.issn=0143005X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-27 N1 - Date created - 1988-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Epidemiol. 1986 Jun;15(2):164-70 [3721677] J Natl Cancer Inst. 1985 Feb;74(2):377-81 [2857796] Int J Epidemiol. 1984 Sep;13(3):311-8 [6149198] J Natl Cancer Inst. 1983 Dec;71(6):1151-5 [6140323] Br J Cancer. 1982 Nov;46(5):749-56 [6128995] J Natl Cancer Inst. 1980 Nov;65(5):1055-61 [6933238] Cancer Res. 1986 Sep;46(9):4812-6 [3731127] Br J Urol. 1963 Mar;35:67-9 [14031378] N Engl J Med. 1980 Jul 10;303(2):112-3 [6104291] Int J Cancer. 1979 May 15;23(5):598-602 [37169] Am J Epidemiol. 1978 Jul;108(1):78-9 [685980] Mayo Clin Proc. 1977 Jan;52(1):3-7 [609284] Eur J Pediatr. 1977 Aug 23;126(1-2):77-84 [20308] Br Med J. 1977 Jul 16;2(6080):191 [871846] J Natl Cancer Inst. 1977 May;58(5):1255-61 [192897] Am J Epidemiol. 1980 Aug;112(2):232-46 [6106385] J Natl Cancer Inst. 1976 Apr;56(4):731-3 [3662] Br J Cancer. 1974 Feb;29(2):176-8 [4830140] Cancer. 1969 May;23(5):1119-21 [5781507] Am J Epidemiol. 1976 Nov;104(5):511-6 [988743] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Issues in biochemical applications to risk assessment: when can lymphocytes be used as surrogate markers? AN - 78020471; 2834193 JF - Environmental health perspectives AU - Lucier, G W AU - Thompson, C L AD - Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 187 EP - 191 VL - 76 SN - 0091-6765, 0091-6765 KW - Biomarkers, Tumor KW - 0 KW - Carcinogens KW - Mutagens KW - Proteins KW - Receptors, Cell Surface KW - Index Medicus KW - Risk KW - Mutagens -- analysis KW - DNA Damage KW - Humans KW - Proteins -- metabolism KW - Mutation KW - DNA Repair -- drug effects KW - Receptors, Cell Surface -- drug effects KW - Cytogenetics KW - Carcinogens -- toxicity KW - Biomarkers, Tumor -- analysis KW - Lymphocytes -- metabolism KW - Lymphocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78020471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Issues+in+biochemical+applications+to+risk+assessment%3A+when+can+lymphocytes+be+used+as+surrogate+markers%3F&rft.au=Lucier%2C+G+W%3BThompson%2C+C+L&rft.aulast=Lucier&rft.aufirst=G&rft.date=1987-12-01&rft.volume=76&rft.issue=&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-07 N1 - Date created - 1988-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinog Compr Surv. 1985;10:511-28 [4064016] J Natl Cancer Inst. 1987 May;78(5):887-98 [3471998] Environ Health Perspect. 1987 Dec;76:141-5 [3447891] Environ Health Perspect. 1987 Dec;76:79-87 [2834196] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Issues in biochemical applications to risk assessment: how do we evaluate individual components of multistage models? AN - 78011543; 3447895 JF - Environmental health perspectives AU - Anderson, M W AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 175 EP - 179 VL - 76 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Index Medicus KW - Risk KW - Animals KW - Mutagenicity Tests KW - DNA Damage KW - Mutation KW - Cell Transformation, Neoplastic KW - Carcinogens -- administration & dosage KW - Neoplasms, Experimental -- chemically induced KW - Carcinogens -- toxicity KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78011543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Issues+in+biochemical+applications+to+risk+assessment%3A+how+do+we+evaluate+individual+components+of+multistage+models%3F&rft.au=Anderson%2C+M+W&rft.aulast=Anderson&rft.aufirst=M&rft.date=1987-12-01&rft.volume=76&rft.issue=&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-07 N1 - Date created - 1988-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 1987 Dec;76:57-63 [3447904] Environ Health Perspect. 1987 Dec;76:163-7 [3447893] Nature. 1983 Jul 7-13;304(5921):67-9 [6866091] Environ Health Perspect. 1987 Dec;76:49-56 [2896122] Science. 1987 Sep 11;237(4820):1309-16 [3629242] Environ Health Perspect. 1987 Dec;76:9-14 [3447906] Environ Health Perspect. 1985 Oct;62:89-94 [4085451] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Implications of pharmacokinetic modeling in risk assessment analysis. AN - 78003716; 3447907 AB - Physiologic pharmacokinetic models are a useful interface between exposure models and risk assessment models by providing a means to estimate tissue concentrations of reactive chemical species at the site of action. The models utilize numerous parameters that can be characterized as anatomical, such as body size or tissue volume; physiological, such as tissue blood perfusion rates, clearances, and metabolism; thermodynamic, such as partition coefficients; and transport, such as membrane permeabilities. The models provide a format to investigate how these parameters can influence the disposition of chemicals throughout the body, which is an important consideration in interpreting toxicity studies. Physiologic models can take into account nonlinear effects related to clearance, metabolism, or transport. They allow for extrapolation of tissue concentration from high dose to low dose experiments and from species to species and can account for temporal variations in dose. JF - Environmental health perspectives AU - Lutz, R J AU - Dedrick, R L AD - Chemical Engineering Section, National Institutes of Health, Bethesda, MD 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 97 EP - 106 VL - 76 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Index Medicus KW - Risk KW - Animals KW - Thermodynamics KW - Dose-Response Relationship, Drug KW - Humans KW - Metabolic Clearance Rate KW - Body Composition KW - Biological Transport, Active KW - Carcinogens -- administration & dosage KW - Carcinogens -- pharmacokinetics KW - Carcinogens -- toxicity KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78003716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Implications+of+pharmacokinetic+modeling+in+risk+assessment+analysis.&rft.au=Lutz%2C+R+J%3BDedrick%2C+R+L&rft.aulast=Lutz&rft.aufirst=R&rft.date=1987-12-01&rft.volume=76&rft.issue=&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-07 N1 - Date created - 1988-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Metab Dispos. 1977 Jul-Aug;5(4):386-96 [19218] Cancer Chemother Rep. 1975 Jul-Aug;59(4):795-804 [1236771] Toxicol Appl Pharmacol. 1978 Jun;44(3):581-91 [567390] J Environ Pathol Toxicol. 1978 Sep-Oct;1(1):163-79 [722184] Fed Proc. 1980 Jan;39(1):54-9 [6766113] Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1939-47 [118803] Toxicol Appl Pharmacol. 1980 Aug;55(1):154-61 [7423500] J Pharmacol Exp Ther. 1981 Dec;219(3):669-74 [7299690] J Pharmacokinet Biopharm. 1982 Feb;10(1):53-75 [7069578] J Pharm Pharmacol. 1982 Sep;34(9):597-600 [6127390] Science. 1983 Mar 4;219(4588):1032-7 [6823565] J Pharmacokinet Biopharm. 1982 Dec;10(6):637-47 [7182459] Drug Metab Dispos. 1984 Sep-Oct;12(5):527-35 [6149901] Biochem Pharmacol. 1973 Oct 1;22(19):2405-17 [4200888] Biochem Pharmacol. 1972 Jan;21(1):1-16 [4500983] Science. 1949 Jun 10;109(2841):579-85 [17835379] J Pharmacokinet Biopharm. 1973 Oct;1(5):435-61 [4787619] Arch Environ Contam Toxicol. 1974 Mar;2(1):9-42 [4828556] J Pharmacol Exp Ther. 1974 Jun;189(3):585-92 [4843162] Cancer Res. 1977 Oct;37(10):3475-83 [908002] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Statistical properties of a two-stage model of carcinogenesis. AN - 78003566; 3447890 AB - Some of the statistical properties of a simple two-stage model of carcinogenesis are explored. The implications of additive treatment effects versus independent treatment effects on the shape of the dose-response curve are considered. Response that is low-dose linear results in the cases where the mutation rates are affected by dose or in the cases where treatment changes the birth rate/death rate of initiated cells in an additive fashion. Independent treatment effects lead to non-low-dose linear response when the survival of initiated cells is affected by treatment. A computer simulation experiment was performed that examined the ability of animal carcinogenesis data to differentiate between various forms of this simple two-stage model. It is shown that animal carcinogenicity experiments do not contain enough data to adequately describe the difference between these two types of effects. JF - Environmental health perspectives AU - Portier, C J AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 125 EP - 131 VL - 76 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Index Medicus KW - Risk KW - Animals KW - Carcinogens -- administration & dosage KW - Dose-Response Relationship, Drug KW - Carcinogens -- toxicity KW - Clone Cells -- drug effects KW - Cocarcinogenesis KW - Neoplasms, Experimental -- chemically induced KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78003566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Statistical+properties+of+a+two-stage+model+of+carcinogenesis.&rft.au=Portier%2C+C+J&rft.aulast=Portier&rft.aufirst=C&rft.date=1987-12-01&rft.volume=76&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-07 N1 - Date created - 1988-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1980 Sep;65(3):559-69 [6931935] Yale J Biol Med. 1980 Sep-Oct;53(5):367-84 [7013284] J Natl Cancer Inst. 1981 Jun;66(6):1037-52 [6941039] Br J Cancer. 1981 Jul;44(1):1-14 [6789853] Cancer Res. 1978 Mar;38(3):865-6 [626986] J Natl Cancer Inst. 1979 Mar;62(3):493-501 [283278] Am J Hum Genet. 1979 Nov;31(6):704-10 [517520] Biometrics. 1981 Jun;37(2):353-66 [7023560] Environ Health Perspect. 1983 Apr;50:285-91 [6873019] Cancer Res. 1985 Apr;45(4):1437-43 [2983882] Cancer Res. 1986 Sep;46(9):4372-8 [3731095] Risk Anal. 1987 Mar;7(1):109-19 [3615992] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of time-variant exposure on toxic substance response. AN - 78000555; 3329094 AB - Sources of time-variant exposure to toxic substances are identified and examined for their effects on the estimation of response. It is shown that only time-averaged target tissue concentrations are required to obtain rigorous risk estimates from the one-hit and multihit models. In contrast, detailed concentration histories need to be retained throughout analyses involving two-event models with intermediate-stage clonal growth advantage (clonal two-stage) and multistage models. Cumulative incidence ratios, based on the exact to time-averaged treatment of concentration time dependencies, are evaluated for substances whose toxic responses exhibit moderate (arsenic) and strong (ethylene dibromide) dependence on time of actual exposure. These ratios reveal that time-averaged dose approximations may lead to several orders of magnitude error in both the multistage and clonal two-stage models if exposure periods are short, and that 3.4-fold (arsenic) and 8-fold (ethylene dibromide) errors still exist even when an actual two-thirds lifetime exposure is averaged over a full lifetime. Finally, the effects of time-variant exposure on risk estimation due to migration and birth-death in an epidemiological setting are examined. A residence time distribution calculation shows that, if these effects are ignored for a population orally exposed to arsenic and characterized by an out-migration rate in excess of 5%/yr, response errors will exceed an order of magnitude. JF - Environmental health perspectives AU - Morrison, P F AD - Biomedical Engineering and Instrumentation Branch, National Institutes of Health, Bethesda, MD 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 133 EP - 139 VL - 76 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Ethylene Dibromide KW - 1N41638RNO KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Animals KW - Arsenic -- toxicity KW - Ethylene Dibromide -- administration & dosage KW - Epidemiologic Methods KW - Humans KW - Ethylene Dibromide -- toxicity KW - Arsenic -- administration & dosage KW - Time Factors KW - Models, Biological KW - Carcinogens -- administration & dosage KW - Carcinogens -- pharmacokinetics KW - Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78000555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Effects+of+time-variant+exposure+on+toxic+substance+response.&rft.au=Morrison%2C+P+F&rft.aulast=Morrison&rft.aufirst=P&rft.date=1987-12-01&rft.volume=76&rft.issue=&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-07 N1 - Date created - 1988-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1980 Apr;64(4):977-89 [6929006] Biometrics. 1977 Mar;33(1):1-30 [843567] J Natl Cancer Inst. 1980 Sep;65(3):559-69 [6931935] Drug Metab Dispos. 1984 Sep-Oct;12(5):527-35 [6149901] Environ Health Perspect. 1977 Aug;19:109-19 [908285] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Placental markers of human exposure to polychlorinated biphenyls and polychlorinated dibenzofurans. AN - 77997106; 2834196 AB - Our studies have evaluated biochemical changes in placentae from humans exposed to rice oil contaminated with polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) in Taiwan. Placentae were obtained from nonsmoking women 4 to 5 years after the exposure had occurred. The exposed individuals ingested approximately 1 to 3 g PCBs and 5 mg PCDFs, and many exhibited symptoms characteristic of PCB poisoning. This disease was termed "Yu-Cheng" in Chinese. Based on data from experimental animal models, we examined a number of parameters in placentae from control and exposed women, including arylhydrocarbon hydroxylase (AHH) activity, cytochrome P-450 isozymes, epidermal growth factor (EGF) receptor binding properties and actions, and Ah receptor. We also quantified concentrations of various PCB and PCDF congeners known to be present in the contaminated rice oil. Our results revealed a dramatic elevation in placental AHH activity in samples from PCB/PCDF-exposed women. This increase in enzyme activity was associated with a parallel increase in placental microsomal protein immunochemically related to cytochrome P-450 form 6 [derived from 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced rabbit lung]. No other cytochrome P-450 isozyme was detected in placental preparations, and the form 6 homolog was found only in placentae from exposed women. EGF receptor-mediated autophosphorylation capacity was significantly diminished in PCB/PCDF placentae, but this effect was not associated with changes in plasma membrane EGF receptor binding properties (Kd and Bmax). The EGF receptor autophosphorylation effect correlated well with the decrease in birthweight observed in offspring of exposed women, suggesting that this biochemical event might provide a good marker of effect for the toxic halogenated aromatics. JF - Environmental health perspectives AU - Lucier, G W AU - Nelson, K G AU - Everson, R B AU - Wong, T K AU - Philpot, R M AU - Tiernan, T AU - Taylor, M AU - Sunahara, G I AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 79 EP - 87 VL - 76 SN - 0091-6765, 0091-6765 KW - Benzofurans KW - 0 KW - Dibenzofurans, Polychlorinated KW - Isoenzymes KW - Plant Oils KW - Receptors, Aryl Hydrocarbon KW - Receptors, Drug KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Receptor, Epidermal Growth Factor -- drug effects KW - Receptors, Drug -- metabolism KW - Receptor, Epidermal Growth Factor -- metabolism KW - Receptors, Drug -- drug effects KW - Humans KW - Adult KW - Cytochrome P-450 Enzyme System -- metabolism KW - Adolescent KW - Isoenzymes -- metabolism KW - Female KW - Pregnancy KW - Food Contamination KW - Polychlorinated Biphenyls -- poisoning KW - Placenta -- drug effects KW - Oryza -- poisoning KW - Benzofurans -- poisoning KW - Placenta -- metabolism KW - Plant Oils -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77997106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Placental+markers+of+human+exposure+to+polychlorinated+biphenyls+and+polychlorinated+dibenzofurans.&rft.au=Lucier%2C+G+W%3BNelson%2C+K+G%3BEverson%2C+R+B%3BWong%2C+T+K%3BPhilpot%2C+R+M%3BTiernan%2C+T%3BTaylor%2C+M%3BSunahara%2C+G+I&rft.aulast=Lucier&rft.aufirst=G&rft.date=1987-12-01&rft.volume=76&rft.issue=&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-07 N1 - Date created - 1988-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Endocrinol. 1983 Jul;31(1):1-19 [6309581] J Biol Chem. 1978 Dec 10;253(23):8640-7 [101550] Am J Ind Med. 1984;5(1-2):71-9 [6230931] Cancer Res. 1984 Sep;44(9):3916-23 [6611202] Mol Pharmacol. 1984 Jul;26(1):90-8 [6087120] Toxicology. 1984 Aug;32(2):131-44 [6464025] Proc Natl Acad Sci U S A. 1984 Dec;81(23):7407-11 [6095293] Lancet. 1985 Mar 30;1(8431):721-4 [2857997] Biochem Biophys Res Commun. 1977 Jun 6;76(3):644-51 [409392] Mol Pharmacol. 1987 Nov;32(5):572-8 [3119985] Drug Metab Dispos. 1975 Sep-Oct;3(5):371-80 [241618] J Biol Chem. 1976 Aug 25;251(16):4936-46 [956169] Science. 1968 May 3;160(3827):541-2 [5644060] CRC Crit Rev Biochem. 1979;6(4):401-37 [378536] Proc Natl Acad Sci U S A. 1979 Oct;76(10):5168-72 [315558] Med Biol. 1979 Oct;57(5):306-12 [522518] Arch Biochem Biophys. 1980 Apr 1;200(2):513-23 [7436419] Bull Environ Contam Toxicol. 1981 Apr;26(4):489-95 [6786399] Arch Environ Health. 1981 Nov-Dec;36(6):321-6 [6797353] Biochem Biophys Res Commun. 1981 Dec 31;103(4):1310-7 [7332594] Dev Pharmacol Ther. 1982;5(3-4):162-72 [7151648] Teratology. 1982 Dec;26(3):259-61 [6819644] Science. 1985 Mar 22;227(4693):1499-502 [3856321] Toxicol Appl Pharmacol. 1985 Feb;77(2):251-9 [2579474] Environ Health Perspect. 1985 Feb;59:121-8 [2985378] Environ Health Perspect. 1985 Feb;59:17-29 [3921359] Environ Health Perspect. 1985 Feb;59:59-65 [3921366] Cancer Res. 1986 Feb;46(2):999-1004 [3079671] J Biol Chem. 1986 Jun 25;261(18):8295-7 [3013845] Toxicol Appl Pharmacol. 1986 Aug;85(1):60-8 [3088776] J Biol Chem. 1984 Jan 25;259(2):980-5 [6319394] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Issues in biochemical applications to risk assessment: are short-term tests predictive of in vivo tumorigenicity? AN - 77994277; 3447893 JF - Environmental health perspectives AU - Tennant, R W AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 163 EP - 167 VL - 76 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Mutagens KW - Index Medicus KW - Salmonella -- drug effects KW - Risk KW - Animals KW - Mutagenicity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77994277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Issues+in+biochemical+applications+to+risk+assessment%3A+are+short-term+tests+predictive+of+in+vivo+tumorigenicity%3F&rft.au=Tennant%2C+R+W&rft.aulast=Tennant&rft.aufirst=R&rft.date=1987-12-01&rft.volume=76&rft.issue=&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-07 N1 - Date created - 1988-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1987 May 22;236(4804):933-41 [3554512] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Issues concerning the estimation of the TD50. AN - 77993555; 3444931 AB - The TD50 (or tumorigenic dose rate 50) is a generally accepted measure of the carcinogenic potency of a chemical in a particular strain of animal. This paper discusses error in the estimation of the TD50 caused by intercurrent mortality and error resulting from consideration of only significant TD50's. Using computer simulations, we found that treatment-related toxicity had only a small effect on estimating the TD50, with errors seldom exceeding 5%. The TD50 is sensitive to changes in tumor lethality with errors ranging to as high as 50%. Many of these errors were significantly different from zero and the results suggest that potency estimation could be improved by basing the estimates upon the tumor incidence rate rather than upon the tumor death rate when an estimate of tumor lethality is obtainable. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Portier, C J AU - Hoel, D G AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 437 EP - 447 VL - 7 IS - 4 SN - 0272-4332, 0272-4332 KW - Carcinogens KW - 0 KW - Index Medicus KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Mice KW - Computer Simulation KW - Neoplasms, Experimental -- chemically induced KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77993555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Issues+concerning+the+estimation+of+the+TD50.&rft.au=Portier%2C+C+J%3BHoel%2C+D+G&rft.aulast=Portier&rft.aufirst=C&rft.date=1987-12-01&rft.volume=7&rft.issue=4&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=02724332&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-27 N1 - Date created - 1988-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - DNA adducts as a dosimeter for risk estimation. AN - 77992805; 3447903 AB - The dose response for O6-methylguanine (O6MG) formation and cytotoxicity was determined in lung and nasal mucosa from Fischer 344 rats during multiple dose administration of the tobacco-specific nitrosamine-4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK). O6MG accumulated in the lung following treatment for 12 days with doses of NNK from 0.3 to 100 mg/kg/day. The dose response for NNK was nonlinear; the O6MG-to-dose ratio, an index of alkylation efficiency, increased dramatically as the dose of carcinogen decreased. These data suggest that low- and high-Km pathways may exist for activation of NNK to a methylating agent. Marked differences in O6MG concentration were observed in specific lung cell populations. The Clara cell, one of the suggested progenitor cells for nitrosamine-induced neoplasia, was found to possess the greatest concentration of O6MG. Moreover, as the dose of NNK was decreased from 100 to 0.3 mg/kg, the alkylation efficiency in this cell population increased 38-fold. The presence of a high-affinity pathway in the Clara cell for activation of NNK may contribute to the potent carcinogenicity observed following low-dose exposure to this tobacco-specific carcinogen. The dose response for O6MG formation differed considerably between the respiratory and olfactory mucosa from the nasal passages of the rat. The dose response was nonlinear in respiratory mucosa but linear in olfactory mucosa. The alkylation efficiency increased dramatically only in the respiratory mucosa as the dose of NNK was decreased. These studies suggest that a low Km pathway for NNK activation is also present in the nose and that this pathway is localized predominantly in the respiratory region.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Environmental health perspectives AU - Belinsky, S A AU - White, C M AU - Devereux, T R AU - Anderson, M W AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 3 EP - 8 VL - 76 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Nitrosamines KW - Guanine KW - 5Z93L87A1R KW - 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone KW - 7S395EDO61 KW - DNA KW - 9007-49-2 KW - O-(6)-methylguanine KW - 9B710FV2AE KW - Index Medicus KW - Animals KW - Nitrosamines -- toxicity KW - Dose-Response Relationship, Drug KW - Lung -- metabolism KW - Nasal Mucosa -- drug effects KW - Nasal Mucosa -- metabolism KW - Guanine -- metabolism KW - Alkylation KW - Nitrosamines -- administration & dosage KW - Rats KW - Risk KW - Respiratory Tract Neoplasms -- chemically induced KW - Rats, Inbred F344 KW - Lung -- drug effects KW - Guanine -- analogs & derivatives KW - Carcinogens -- administration & dosage KW - DNA Damage KW - DNA -- metabolism KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77992805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=DNA+adducts+as+a+dosimeter+for+risk+estimation.&rft.au=Belinsky%2C+S+A%3BWhite%2C+C+M%3BDevereux%2C+T+R%3BAnderson%2C+M+W&rft.aulast=Belinsky&rft.aufirst=S&rft.date=1987-12-01&rft.volume=76&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-07 N1 - Date created - 1988-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cancer Res Clin Oncol. 1984;108(1):81-6 [6746721] Cancer Res. 1986 Mar;46(3):1280-4 [3943097] Cancer Res. 1987 Feb 15;47(4):1143-8 [3802095] Cancer Res. 1987 Mar 15;47(6):1577-81 [3815358] Cancer Res. 1980 Nov;40(11):4144-50 [7471055] Science. 1983 Mar 4;219(4588):1032-7 [6823565] Proc Natl Acad Sci U S A. 1984 Mar;81(6):1692-5 [6584902] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dose-dependent changes in the antigenicity of bacterial endotoxin exposed to ionizing radiation. AN - 77992790; 2452255 AB - The antigenic properties of the highly purified US reference standard endotoxin (RSE) exposed to varying doses of ionizing radiation were studied with double immunodiffusion, immunoelectrophoresis and immunoblotting. Rabbit RSE antisera identified 2 distinct major antigenic components for untreated RSE: one related to the O-polysaccharide side chain ("O-antigenic specificity"), the other to the R-core. Based on a serologic cross-reactivity of R-core of RSE (Escherichia coli 0113) with the R-core of the lipopolysaccharide from E. coli 0111, the core type of E. coli 0113 was identified as coli R3. Increasing exposure of RSE to ionizing radiation progressively destroyed all antigenic reactivities: at lower doses of radiation the rate of elimination differed for the 2 antigen classes. The O-polysaccharide was more sensitive to gamma-radiation than the R-core and the O-antigenicity was lost before that of the R-core. Endotoxin molecules containing incomplete R-core (radiation-induced or mutant) did not react with the RSE antiserum. JF - Journal of clinical & laboratory immunology AU - Csako, G AU - Suba, E A AU - Tsai, C M AU - Mocca, L F AU - Elin, R J AD - Clinical Pathology Department, National Institutes of Health, Bethesda, MD 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 193 EP - 198 VL - 24 IS - 4 SN - 0141-2760, 0141-2760 KW - Antigens, Bacterial KW - 0 KW - Endotoxins KW - Epitopes KW - Lipopolysaccharides KW - Index Medicus KW - Animals KW - Lipopolysaccharides -- radiation effects KW - Lipopolysaccharides -- immunology KW - Immunoelectrophoresis KW - Gamma Rays KW - Immunodiffusion KW - Epitopes -- radiation effects KW - Electrophoresis, Polyacrylamide Gel KW - Rabbits KW - Dose-Response Relationship, Radiation KW - Epitopes -- immunology KW - Antigens, Bacterial -- radiation effects KW - Endotoxins -- radiation effects KW - Endotoxins -- standards KW - Antigens, Bacterial -- immunology KW - Endotoxins -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77992790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+%26+laboratory+immunology&rft.atitle=Dose-dependent+changes+in+the+antigenicity+of+bacterial+endotoxin+exposed+to+ionizing+radiation.&rft.au=Csako%2C+G%3BSuba%2C+E+A%3BTsai%2C+C+M%3BMocca%2C+L+F%3BElin%2C+R+J&rft.aulast=Csako&rft.aufirst=G&rft.date=1987-12-01&rft.volume=24&rft.issue=4&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+%26+laboratory+immunology&rft.issn=01412760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-02 N1 - Date created - 1988-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cellular and molecular mechanisms of multistep carcinogenesis: relevance to carcinogen risk assessment. AN - 77992599; 3447905 AB - Carcinogenesis is a multistep process involving alterations in at least two distinct classes of genes. Protooncogenes are activated qualitatively or quantitatively in certain tumors, and they appear to act as positive proliferative signals for neoplastic growth. In contrast, tumor suppressor genes are normal genes that must be inactivated or lost for tumor development. When active, tumor suppressor genes control neoplastic growth in a negative manner. Chemicals may influence the carcinogenic process by mutational activation of protooncogenes and/or inactivation of tumor suppressor genes. The types of genetic alterations involved in these mutational events are diverse, and their dose-response curves may be varied. In addition, chemical carcinogens may act on nonmutational processes such as the clonal expansion of premalignant cells. The carcinogenic risk of a specific chemical is a composite of its effects on multiple genetic and epigenetic processes. JF - Environmental health perspectives AU - Barrett, J C AU - Wiseman, R W AD - National Institute of Environmental Health Sciences, Research Traingle Park, NC 27709. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 65 EP - 70 VL - 76 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Index Medicus KW - Risk KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Suppression, Genetic -- drug effects KW - Models, Biological KW - Proto-Oncogenes -- drug effects KW - Cocarcinogenesis KW - Carcinogens -- administration & dosage KW - Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77992599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cellular+and+molecular+mechanisms+of+multistep+carcinogenesis%3A+relevance+to+carcinogen+risk+assessment.&rft.au=Barrett%2C+J+C%3BWiseman%2C+R+W&rft.aulast=Barrett&rft.aufirst=J&rft.date=1987-12-01&rft.volume=76&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-07 N1 - Date created - 1988-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1985 Apr;45(4):1437-43 [2983882] J Supramol Struct Cell Biochem. 1981;17(2):133-46 [7033553] Nature. 1985 May 30-Jun 5;315(6018):382-5 [3923365] Nature. 1985 Aug 15-21;316(6029):636-9 [2993900] Carcinogenesis. 1985 Nov;6(11):1607-10 [2414025] Science. 1985 Nov 15;230(4727):770-6 [2997917] Cancer Res. 1986 Apr;46(4 Pt 1):1573-80 [2418950] Cancer Res. 1986 Jun;46(6):2863-5 [3084079] Virchows Arch B Cell Pathol Incl Mol Pathol. 1980;33(3):303-4 [6110278] CRC Crit Rev Toxicol. 1974 Jan;2(4):419-43 [4822436] Carcinogenesis. 1981;2(12):1375-9 [7326837] Carcinogenesis. 1982;3(8):895-8 [6812976] Nature. 1976 Mar 4;260(5546):17-20 [1264187] Science. 1978 Jun 30;200(4349):1448-59 [96525] Cancer Res. 1980 Apr;40(4):1194-203 [7357549] Cancer Res. 1983 May;43(5):2034-41 [6403231] J Natl Cancer Inst. 1983 Mar;70(3):455-63 [6572736] Nature. 1983 Jul 7-13;304(5921):67-9 [6866091] Environ Health Perspect. 1983 Apr;50:309-20 [6873021] Nature. 1983 Oct 27-Nov 2;305(5937):779-84 [6633649] Cancer Lett. 1983 Dec;21(2):141-7 [6652618] Science. 1984 Mar 9;223(4640):1028-33 [6320372] Science. 1984 Jun 8;224(4653):1121-4 [6719137] Environ Res. 1984 Aug;34(2):227-41 [6086305] Proc Natl Acad Sci U S A. 1984 Aug;81(15):4940-4 [6589638] Nature. 1986 Jul 3-9;322(6074):78-80 [3014349] Proc Natl Acad Sci U S A. 1986 Aug;83(16):5825-9 [3016723] Proc Natl Acad Sci U S A. 1986 Aug;83(16):5992-6 [3461473] Carcinogenesis. 1986 Nov;7(11):1845-8 [3769132] Science. 1987 Jan 9;235(4785):177-82 [3798106] Science. 1987 Jan 16;235(4786):305-11 [3541204] Proc Natl Acad Sci U S A. 1987 Apr;84(7):2029-32 [3104907] Science. 1987 Sep 11;237(4820):1309-16 [3629242] Cancer Res. 1950 Nov;10(11):713-7 [14783769] Arch Environ Health. 1963 Dec;7:668-74 [14077213] J Natl Cancer Inst. 1985 Apr;74(4):735-40 [3921746] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cancer risk models for ionizing radiation. AN - 77987210; 3447889 AB - Risk estimation in radiation carcinogenesis depends primarily on epidemiological data and hazard rate models. The A-bomb survivors follow-up provides information on the complexity of this process. Several hazard rate models are briefly discussed and illustrated using the A-bomb experience. JF - Environmental health perspectives AU - Hoel, D G AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 121 EP - 124 VL - 76 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Risk KW - Epidemiologic Methods KW - Nuclear Warfare KW - Humans KW - Leukemia, Radiation-Induced -- etiology KW - Leukemia, Radiation-Induced -- mortality KW - Dose-Response Relationship, Radiation KW - Male KW - Japan KW - Female KW - Neoplasms, Radiation-Induced -- etiology KW - Neoplasms, Radiation-Induced -- mortality KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77987210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cancer+risk+models+for+ionizing+radiation.&rft.au=Hoel%2C+D+G&rft.aulast=Hoel&rft.aufirst=D&rft.date=1987-12-01&rft.volume=76&rft.issue=&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-07 N1 - Date created - 1988-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 1977 Nov;106(5):418-32 [920729] J Natl Cancer Inst. 1980 Aug;65(2):353-76 [6931253] J Epidemiol Community Health. 1984 Jun;38(2):108-12 [6747507] Health Phys. 1987 Jan;52(1):55-63 [3804743] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Failure of diterpenes from Jatropha curcas to induce mutation in Salmonella typhimurium TA98 and TA100. AN - 77959741; 3326080 AB - No mutagenicity of five diterpenes isolated from the roots of Jatropha curcas was detected by Ame's test using both TA98 and TA100 tester strains with or without S-9 fraction from livers of rats treated with polychlorinated biphenyl. JF - Research communications in chemical pathology and pharmacology AU - Rojanapo, W AU - Pimbua, J AU - Glinsukon, T AU - Naengchomnong, W AU - Thebtaranonth, Y AD - Research Division, National Cancer Institute, Bangkok, Thailand. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 397 EP - 400 VL - 58 IS - 3 SN - 0034-5164, 0034-5164 KW - Diterpenes KW - 0 KW - Mutagens KW - Index Medicus KW - Rats KW - Animals KW - Mutagenicity Tests KW - Biotransformation KW - Microsomes, Liver -- metabolism KW - In Vitro Techniques KW - Salmonella typhimurium -- genetics KW - Diterpenes -- pharmacokinetics KW - Plants, Medicinal -- analysis KW - Diterpenes -- toxicity KW - Mutagens -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77959741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+communications+in+chemical+pathology+and+pharmacology&rft.atitle=Failure+of+diterpenes+from+Jatropha+curcas+to+induce+mutation+in+Salmonella+typhimurium+TA98+and+TA100.&rft.au=Rojanapo%2C+W%3BPimbua%2C+J%3BGlinsukon%2C+T%3BNaengchomnong%2C+W%3BThebtaranonth%2C+Y&rft.aulast=Rojanapo&rft.aufirst=W&rft.date=1987-12-01&rft.volume=58&rft.issue=3&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Research+communications+in+chemical+pathology+and+pharmacology&rft.issn=00345164&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-07 N1 - Date created - 1988-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of a hepatic proliferation inhibitor (HPI): effect of HPI on the growth of normal liver cells--comparison with transforming growth factor beta. AN - 77959694; 3126196 AB - Improvements in the purification of a hepatic proliferation inhibitor (HPI) from adult rat liver have yielded a product that has an inhibitory activity 1,000-fold greater than previously reported. The growth inhibitory activity, which could be eluted from SDS-PAGE at 17-19 kilodaltons (kD), was compared to that of transforming growth factor beta (TGF-beta). The ID50 of the HPI preparation in Fischer rat liver epithelial cells was 50 pg/ml (2.5 pM) compared to a value of 260 pg/ml (10.4 pM) obtained for pure human TGF-beta. Both inhibitors also modulated the stimulation of DNA synthesis in primary hepatocytes by either epidermal growth factor or a growth stimulatory activity prepared from serum of hepatectomized rats. The ID50s of HPI and TGF-beta in these cells were 250 pg/ml and 40 pg/ml, respectively. In contrast to TGF-beta the growth inhibitory activity of HPI was unaltered in the presence of an antibody raised against TGF-beta. The possible mechanism of action of HPI is discussed. JF - Journal of cellular biochemistry AU - Huggett, A C AU - Krutzsch, H C AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 305 EP - 314 VL - 35 IS - 4 SN - 0730-2312, 0730-2312 KW - Growth Inhibitors KW - 0 KW - Peptides KW - Proteins KW - Transforming Growth Factors KW - 76057-06-2 KW - DNA KW - 9007-49-2 KW - Arginase KW - EC 3.5.3.1 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Electrophoresis, Polyacrylamide Gel KW - Cells, Cultured KW - Cell Division -- drug effects KW - DNA -- biosynthesis KW - Male KW - Proteins -- pharmacology KW - Liver -- cytology KW - Liver -- growth & development KW - Liver -- drug effects KW - Growth Inhibitors -- pharmacology KW - Peptides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77959694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+biochemistry&rft.atitle=Characterization+of+a+hepatic+proliferation+inhibitor+%28HPI%29%3A+effect+of+HPI+on+the+growth+of+normal+liver+cells--comparison+with+transforming+growth+factor+beta.&rft.au=Huggett%2C+A+C%3BKrutzsch%2C+H+C%3BThorgeirsson%2C+S+S&rft.aulast=Huggett&rft.aufirst=A&rft.date=1987-12-01&rft.volume=35&rft.issue=4&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+biochemistry&rft.issn=07302312&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-19 N1 - Date created - 1988-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Arabinosyl-5-azacytosine: a novel nucleoside entering clinical trials. AN - 77959214; 2449402 AB - Arabinosyl-5-azacytosine is a new compound which has been selected by the Division of Cancer Treatment, National Cancer Institute for clinical development as an antineoplastic agent based on its high degree of activity against a broad range of tumor types in preclinical studies. Therapeutic activity has been observed against murine and human leukemias, transplantable murine solid tumors, and human tumor xenografts. Arabinosyl-5-azacytosine exhibited a broader spectrum of activity against human solid tumors than cytosine arabinoside. Arabinosyl-5-azacytosine is phosphorylated to the nucleotide level by deoxycytidine kinase. Upon further anabolism to the triphosphate level, it can be incorporated into DNA. The mechanism of cytotoxicity is thought to be related to inhibition of DNA synthesis. Leukemic and solid tumor cell lines that are resistant to cytosine arabinoside due to deletion of deoxycytidine kinase activity are cross-resistant to arabinosyl-5-azacytosine. Unlike cytosine arabinoside, arabinosyl-5-azacytosine does not readily undergo deamination. Schedule dependence has been demonstrated in mice bearing L1210 leukemia, with superior activity seen with multiple doses administered on each treatment day compared to administration of larger but less frequently administered doses. From preliminary data in solid tumor models, however, antitumor activity did not appear to be superior with continuous infusion compared to that observed on a bolus schedule. Preclinical toxicology studies indicated that the bone marrow and gastrointestinal tract were the main target organs. A single large dose of arabinosyl-5-azacytosine could be tolerated by both mice and dogs. When administered as a continuous infusion, the toxicity was related to both the dose and duration of exposure, suggesting that toxicity resulted from a critical time above a threshold concentration as opposed to the total area under the concentration-time curve. Phase I clinical trials have been initiated to determine the maximum tolerated dose on a low dose continuous infusion schedule for 72 hours and also on a high dose short infusion daily times five schedule. JF - Investigational new drugs AU - Grem, J L AU - Shoemaker, D D AU - Hoth, D F AU - King, S A AU - Plowman, J AU - Zaharko, D AU - Grieshaber, C K AU - Harrison, S D AU - Cradock, J C AU - Leyland-Jones, B AD - Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 315 EP - 328 VL - 5 IS - 4 SN - 0167-6997, 0167-6997 KW - Antiviral Agents KW - 0 KW - fazarabine KW - 5V71D8JOKK KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Humans KW - Antiviral Agents -- therapeutic use KW - Azacitidine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77959214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+new+drugs&rft.atitle=Arabinosyl-5-azacytosine%3A+a+novel+nucleoside+entering+clinical+trials.&rft.au=Grem%2C+J+L%3BShoemaker%2C+D+D%3BHoth%2C+D+F%3BKing%2C+S+A%3BPlowman%2C+J%3BZaharko%2C+D%3BGrieshaber%2C+C+K%3BHarrison%2C+S+D%3BCradock%2C+J+C%3BLeyland-Jones%2C+B&rft.aulast=Grem&rft.aufirst=J&rft.date=1987-12-01&rft.volume=5&rft.issue=4&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Investigational+new+drugs&rft.issn=01676997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-07 N1 - Date created - 1988-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Adrenocortical function in type II hyperlipoproteinemic patients treated with lovastatin (mevinolin). AN - 77957194; 2831127 AB - Lovastatin (Mevinolin), a competitive inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase, has been used effectively as a hypocholesterolemic agent in man. As an inhibitor of endogenous cholesterol synthesis, a potentially serious side effect of therapy with this drug is interference with adrenocortical function. The effect of lovastatin on adrenal function was evaluated in a 6-month, randomized, double blinded, placebo-controlled, crossover study involving 24 type II hyperlipoproteinemic patients. Despite significant lowering of total and low density lipoprotein (LDL) cholesterol by lovastatin, no statistically or clinically significant differences were seen in free cortisol excretion or in plasma cortisol response to intravenous ACTH infusion between baseline, placebo, and lovastatin-treated patients. We conclude that lovastatin does not adversely affect adrenocortical reserve in patients with heterozygous familial hypercholesterolemia (FH) or non-FH type II hyperlipoproteinemia. JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme AU - Fojo, S S AU - Hoegg, J M AU - Lackner, K J AU - Anchors, J M AU - Bailey, K R AU - Brewer, H B AD - Molecular Disease Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 648 EP - 652 VL - 19 IS - 12 SN - 0018-5043, 0018-5043 KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Lovastatin KW - 9LHU78OQFD KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Humans KW - Heterozygote KW - Adrenocorticotropic Hormone -- pharmacology KW - Hydrocortisone -- blood KW - Lovastatin -- adverse effects KW - Hyperlipoproteinemia Type II -- blood KW - Hyperlipoproteinemia Type II -- physiopathology KW - Lovastatin -- therapeutic use KW - Hyperlipoproteinemia Type II -- drug therapy KW - Adrenal Cortex -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77957194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hormone+and+metabolic+research+%3D+Hormon-+und+Stoffwechselforschung+%3D+Hormones+et+metabolisme&rft.atitle=Adrenocortical+function+in+type+II+hyperlipoproteinemic+patients+treated+with+lovastatin+%28mevinolin%29.&rft.au=Fojo%2C+S+S%3BHoegg%2C+J+M%3BLackner%2C+K+J%3BAnchors%2C+J+M%3BBailey%2C+K+R%3BBrewer%2C+H+B&rft.aulast=Fojo&rft.aufirst=S&rft.date=1987-12-01&rft.volume=19&rft.issue=12&rft.spage=648&rft.isbn=&rft.btitle=&rft.title=Hormone+and+metabolic+research+%3D+Hormon-+und+Stoffwechselforschung+%3D+Hormones+et+metabolisme&rft.issn=00185043&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-14 N1 - Date created - 1988-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Induction of glucagon sensitivity in a transformed kidney cell line by prostaglandin E2 and its inhibition by epidermal growth factor. AN - 77945543; 2830489 AB - A model system using a transformed dog kidney cell line (Madin-Darby canine kidney), has been established for studying the process of differentiation. Glucagon responsiveness can be restored to these transformed cells by various differentiation inducers, including prostaglandin E2. Glucagon response was measured in terms of the ability of glucagon to stimulate cAMP production. Induction of glucagon sensitivity seems to be mediated by cAMP. The ability of various prostaglandin analogs to elevate the cAMP level correlates closely with their ability to induce glucagon sensitivity. In fact, 8-Br-cAMP is also a potent inducer. To define the nature of this cAMP-mediated process, we identified several inhibitors of this induction process. These differentiation inhibitors include serum, phorbol ester, and epidermal growth factor. These inhibitors do not have a direct effect on cAMP production by cells in the presence or absence of hormones. Furthermore, induction by 8-Br-cAMP is also inhibited by these agents. Therefore, the site of inhibition is located beyond the point of cAMP production. Possible interaction between cAMP- and epidermal growth factor-dependent phosphorylations is discussed. JF - Molecular and cellular biology AU - Lin, M C AU - Darfler, F J AU - Beckner, S K AD - Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 4324 EP - 4328 VL - 7 IS - 12 SN - 0270-7306, 0270-7306 KW - Prostaglandins KW - 0 KW - Prostaglandins E KW - 8-Bromo Cyclic Adenosine Monophosphate KW - 23583-48-4 KW - Epidermal Growth Factor KW - 62229-50-9 KW - Glucagon KW - 9007-92-5 KW - Cyclic AMP KW - E0399OZS9N KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Blood KW - Animals KW - Kidney KW - Dogs KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Line, Transformed KW - Cell Differentiation -- drug effects KW - Prostaglandins -- pharmacology KW - 8-Bromo Cyclic Adenosine Monophosphate -- pharmacology KW - Cyclic AMP -- biosynthesis KW - Prostaglandins E -- pharmacology KW - Glucagon -- pharmacology KW - Epidermal Growth Factor -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77945543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Induction+of+glucagon+sensitivity+in+a+transformed+kidney+cell+line+by+prostaglandin+E2+and+its+inhibition+by+epidermal+growth+factor.&rft.au=Lin%2C+M+C%3BDarfler%2C+F+J%3BBeckner%2C+S+K&rft.aulast=Lin&rft.aufirst=M&rft.date=1987-12-01&rft.volume=7&rft.issue=12&rft.spage=4324&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-01 N1 - Date created - 1988-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1977 May 25;252(10):3554-7 [193837] Methods Enzymol. 1985;109:356-60 [2985924] Science. 1985 Jul 19;229(4710):267-9 [2990047] Proc Natl Acad Sci U S A. 1986 Jan;83(2):236-40 [3079907] Biochem Biophys Res Commun. 1977 Jun 20;76(4):1181-7 [302703] Nature. 1978 Nov 16;276(5685):274-5 [714157] Nature. 1979 May 24;279(5711):336-8 [221826] J Biol Chem. 1979 Sep 25;254(18):9317-23 [225326] Proc Natl Acad Sci U S A. 1979 Jul;76(7):3338-42 [291007] J Biol Chem. 1980 May 25;255(10):4834-42 [6246084] J Biol Chem. 1981 Feb 10;256(3):1396-403 [6256395] Endocrinology. 1982 Oct;111(4):1192-200 [6180889] Exp Cell Res. 1982 Nov;142(1):181-9 [6291963] Proc Natl Acad Sci U S A. 1983 Jan;80(1):36-40 [6296873] J Biol Chem. 1983 Mar 10;258(5):2789-94 [6298205] J Biol Chem. 1983 Jun 25;258(12):7386-94 [6134722] Nature. 1983 Dec 1-7;306(5942):487-90 [6196643] Exp Cell Res. 1984 May;152(1):31-7 [6325222] Mol Cell Endocrinol. 1984 Feb;34(2):113-9 [6325268] Methods Enzymol. 1985;109:360-5 [2985925] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Patch-clamp study of the calcium-dependent chloride current in AtT-20 pituitary cells. AN - 77940852; 2449518 AB - 1. Voltage-clamp recordings were made from cultured AtT-20 pituitary cells using the whole-cell patch-clamp technique. Cells were perfused internally with Cs+ to block K+ currents and bathed externally with either 1 microM tetrodotoxin or with tetraethylammonium (TEA) as a Na+ substitute to block voltage-activated Na+ currents. 2. Depolarizing voltage steps from a holding potential of -80 mV to potentials positive to -30 mV evoked two currents: a fast inward current that activated between -30 and +70 mV and a slowly activating current (designated "slow step current") that was inward between -30 and near 0 mV (the Cl- equilibrium potential) and outward positive to about 0 mV. Repolarization to -80 mV revealed a slowly decaying, inward tail current, whose magnitude with respect to step potential closely matched the current-voltage relationship of the voltage-activated Ca2+ current. 3. Activation of the fast inward current, slow step current, and tail current, was prevented by extracellular application of Cd2+ or removal of extracellular Ca2+. Replacement of extracellular Ca2+ with Ba2+ potentiated the fast inward current but blocked the slow step and tail currents. Intracellular perfusion with greater than 1 mM of the Ca2+ chelators ethyleneglycol-bis(beta-aminoethylether)-N,N'-tetraacetic acid (EGTA) or [1,2-bis(2)aminophenoxy]ethane N,N,N',N'-tetraacetic acid (BAPTA) prevented activation of the slow step and tail currents, but not the fast inward current. 4. The reversal potential of the slow inward current was sensitive to changes in the Cl- equilibrium potential but not to substitution of TEA for Na+. The slow step current, but not the fast inward current, was partially blocked by the Cl- channel blocker, 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid. 5. These data indicate that both the slow inward tail current and the slowly activating, reversible step current were a Ca2+-dependent Cl- current, similar to that described in other neuronal and nonneuronal cell types. The fast inward current was a voltage-activated Ca2+ current, described previously in these and other cells. 6. In the absence of intracellular EGTA, the tail current decayed with complex kinetics, its time course apparently dependent on the magnitude of the voltage-activated Ca2+ current. In the presence of 200 microM intracellular EGTA, the tail current decayed significantly faster and often decayed exponentially. JF - Journal of neurophysiology AU - Korn, S J AU - Weight, F F AD - Section on Electrophysiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1431 EP - 1451 VL - 58 IS - 6 SN - 0022-3077, 0022-3077 KW - Chlorides KW - 0 KW - Ion Channels KW - Tetraethylammonium Compounds KW - Cesium KW - 1KSV9V4Y4I KW - Barium KW - 24GP945V5T KW - Tetrodotoxin KW - 4368-28-9 KW - Tetraethylammonium KW - 66-40-0 KW - Sodium KW - 9NEZ333N27 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Cesium -- pharmacology KW - Animals KW - Tetraethylammonium Compounds -- pharmacology KW - Chlorides -- metabolism KW - Pituitary Neoplasms KW - Sodium -- pharmacology KW - Kinetics KW - Membrane Potentials -- drug effects KW - Tetrodotoxin -- pharmacology KW - Barium -- pharmacology KW - Cell Line KW - Chlorides -- pharmacology KW - Ion Channels -- drug effects KW - Calcium -- pharmacology KW - Ion Channels -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77940852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurophysiology&rft.atitle=Patch-clamp+study+of+the+calcium-dependent+chloride+current+in+AtT-20+pituitary+cells.&rft.au=Korn%2C+S+J%3BWeight%2C+F+F&rft.aulast=Korn&rft.aufirst=S&rft.date=1987-12-01&rft.volume=58&rft.issue=6&rft.spage=1431&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurophysiology&rft.issn=00223077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-25 N1 - Date created - 1988-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transfer of di(2-ethylhexyl) phthalate through rat milk and effects on milk composition and the mammary gland. AN - 77912004; 2892284 AB - Five daily oral doses of di(2-ethylhexyl) phthalate (DEHP) (2 g/kg) given to rats on Days 2-6, 6-10, or 14-18 of lactation caused significant decreases in body weight and increases in hepatic peroxisomal enzymes palmitoyl CoA oxidase and carnitine acetyltransferase in the dams and their suckling pups. Plasma cholesterol and triglyceride levels were decreased in the lactating dams. Decreased food consumption, as indicated by pair-fed rats, accounted for the decreased body weight in the pups but not the increases in enzyme activities. To determine whether DEHP and mono(2-ethylhexyl) phthalate (MEHP) were transferred through the milk, milk and plasma were collected from lactating rats 6 hr after the third dose of DEHP. The milk contained 216 +/- 23 micrograms/ml DEHP and 25 +/- 6 micrograms/ml MEHP (mean +/- SE), while the plasma contained less than 0.5 micrograms/ml DEHP and 75 +/- 12 micrograms/ml MEHP. The high milk/plasma ratio for DEHP (greater than 200) indicates efficient extraction of DEHP from the plasma into the milk. DEHP dosing during lactation also caused a decrease in mammary gland weight and a decrease in mammary gland RNA content which reflects synthetic activity. The water content of the milk was reduced, which probably accounted for the increase in lipid in the milk. Milk lactose was decreased in DEHP-treated and pair-fed rats, consistent with the decrease in milk production. The results show that exposure to high doses of DEHP during lactation in rats can result in changes in milk quality and quantity and can lead to DEHP and MEHP exposure in the suckling rat pups. JF - Toxicology and applied pharmacology AU - Dostal, L A AU - Weaver, R P AU - Schwetz, B A AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 315 EP - 325 VL - 91 IS - 3 SN - 0041-008X, 0041-008X KW - Lipids KW - 0 KW - Phthalic Acids KW - Diethylhexyl Phthalate KW - C42K0PH13C KW - Carnitine O-Acetyltransferase KW - EC 2.3.1.7 KW - Palmitoyl-CoA Hydrolase KW - EC 3.1.2.2 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Lipids -- blood KW - Animals KW - Drug Administration Schedule KW - Animals, Suckling -- metabolism KW - Palmitoyl-CoA Hydrolase -- metabolism KW - Body Weight -- drug effects KW - Carnitine O-Acetyltransferase -- metabolism KW - Female KW - Pregnancy KW - Lactation -- drug effects KW - Milk -- metabolism KW - Mammary Glands, Animal -- drug effects KW - Milk -- drug effects KW - Diethylhexyl Phthalate -- toxicity KW - Diethylhexyl Phthalate -- pharmacokinetics KW - Diethylhexyl Phthalate -- analogs & derivatives KW - Phthalic Acids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77912004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Transfer+of+di%282-ethylhexyl%29+phthalate+through+rat+milk+and+effects+on+milk+composition+and+the+mammary+gland.&rft.au=Dostal%2C+L+A%3BWeaver%2C+R+P%3BSchwetz%2C+B+A&rft.aulast=Dostal&rft.aufirst=L&rft.date=1987-12-01&rft.volume=91&rft.issue=3&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-02 N1 - Date created - 1988-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Epidemiology of acute myelogenous leukemia. AN - 77898392; 3321440 AB - The epidemiologic literature suggests that environmental exposures, familial susceptibility, and cytogenetic changes affect AML risk in childhood and adulthood. Unfortunately, many studies are limited by inadequate sample sizes, imprecise case definition, or inadequate exposure measurement. Few studies have singled out AML alone, either because of insufficient numbers or because methods of case ascertainment made it difficult to distinguish specific cell types. Studies of total leukemia or all acute leukemias offer insights into potential risk factors for AML, but may also be misleading in instances when few AML patients were actually included. Future studies should include adequate numbers of patients with AML. At the same time, further refinement of case definition through parameters such as specific cytogenetic changes may make risk factor identification in epidemiologic studies more likely. JF - Seminars in oncology AU - Sandler, D P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 359 EP - 364 VL - 14 IS - 4 SN - 0093-7754, 0093-7754 KW - Index Medicus KW - United States KW - Humans KW - Adult KW - Environmental Exposure KW - Child KW - Leukemia, Myeloid, Acute -- epidemiology KW - Leukemia, Myeloid, Acute -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77898392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+oncology&rft.atitle=Epidemiology+of+acute+myelogenous+leukemia.&rft.au=Sandler%2C+D+P&rft.aulast=Sandler&rft.aufirst=D&rft.date=1987-12-01&rft.volume=14&rft.issue=4&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Seminars+in+oncology&rft.issn=00937754&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-25 N1 - Date created - 1988-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Organic cation secretion in flounder renal tissue. AN - 77894687; 2962510 AB - In the winter flounder, Pseudopleuronectes americanus, renal clearance experiments showed that the model organic cations, tetraethylammonium (TEA) and N'-methylnicotinamide (NMN), were strongly secreted; organic cation-to-polyethylene glycol (glomerular filtration rate marker) clearance ratios averaged 130 and 30, respectively. TEA uptake by isolated renal tubular masses was concentrative and saturable. Transport was inhibited by competitor organic cations and reduced by exposure to NaCN,2,4-dinitrophenol, ouabain, and HgCl2. Organic anions did not reduce TEA uptake. NMN was the poorest inhibitor of TEA uptake of all the organic cations tested. In addition, the rate of NMN uptake was slower than that of TEA, and the steady-state tissue-to-medium ratio was lower (5 for NMN vs. 10 for TEA; both at 25 microM). The data show the presence of an organic cation secretory system in flounder tissue that resembles the mammalian systems in several respects. JF - The American journal of physiology AU - Miller, D S AU - Holohan, P D AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - R861 EP - R867 VL - 253 IS - 6 Pt 2 SN - 0002-9513, 0002-9513 KW - Cations KW - 0 KW - Dinitrophenols KW - Tetraethylammonium Compounds KW - Niacinamide KW - 25X51I8RD4 KW - Mercuric Chloride KW - 53GH7MZT1R KW - Ouabain KW - 5ACL011P69 KW - Sodium Cyanide KW - O5DDB9Z95G KW - 2,4-Dinitrophenol KW - Q13SKS21MN KW - N(1)-methylnicotinamide KW - UM47085BXC KW - Index Medicus KW - Niacinamide -- secretion KW - Sodium Cyanide -- pharmacology KW - Animals KW - Reference Values KW - Glomerular Filtration Rate KW - Niacinamide -- analogs & derivatives KW - Dinitrophenols -- pharmacology KW - Mercuric Chloride -- pharmacology KW - Biological Transport, Active KW - Ouabain -- pharmacology KW - Tetraethylammonium Compounds -- secretion KW - Kidney -- secretion KW - Flatfishes -- physiology KW - Flounder -- physiology KW - Cations -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77894687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Organic+cation+secretion+in+flounder+renal+tissue.&rft.au=Miller%2C+D+S%3BHolohan%2C+P+D&rft.aulast=Miller&rft.aufirst=D&rft.date=1987-12-01&rft.volume=253&rft.issue=6+Pt+2&rft.spage=R861&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-28 N1 - Date created - 1988-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bladder cancer, drinking water source, and tap water consumption: a case-control study. AN - 77891249; 3480378 AB - Data from a population-based case-control interview study of incident bladder cancer in 10 areas of the United States were used to estimate relative risks among white men (2,116 cases, 3,892 controls) and women (689 cases, 1,366 controls) according to beverage intake level and type of water source. Individual year-by-year profiles of water source and treatment were developed by linking lifetime residential information with historical water utility data from an ancillary survey. Risk of bladder cancer increased with intake level of beverages made with tap water. The odds ratio (OR) for the highest vs. lowest quintile of tap water consumption was 1.43 [95% confidence interval (CI) = 1.23, 1.67; chi 2 for trend = 26.3, P less than .001]. The risk gradient with intake was restricted to persons with at least a 40-year exposure to chlorinated surface water and was not found among long-term users of nonchlorinated ground water. The ORs for the highest vs. lowest quintiles of tap water intake were 1.7 and 2.0, respectively, among subjects with 40-59 and greater than or equal to 60 years' exposure. Duration of exposure to chlorinated surface water was associated with bladder cancer risk among women and nonsmokers of both sexes. Among non-smoking respondents with tap water consumption above the population median, the OR increased with exposure duration to a level of 3.1 (CI = 1.3, 7.3; chi 2 for trend = 6.3, P = .01) for greater than or equal to 60 years of residence at places served by chlorinated surface water (vs. non-chlorinated ground water users). These results extend findings of earlier epidemiologic studies and are consistent with environmental chemistry and toxicologic data demonstrating the presence of genotoxic by-products of chlorine disinfection in treated surface waters. JF - Journal of the National Cancer Institute AU - Cantor, K P AU - Hoover, R AU - Hartge, P AU - Mason, T J AU - Silverman, D T AU - Altman, R AU - Austin, D F AU - Child, M A AU - Key, C R AU - Marrett, L D AD - Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1269 EP - 1279 VL - 79 IS - 6 SN - 0027-8874, 0027-8874 KW - Chlorine KW - 4R7X1O2820 KW - Index Medicus KW - United States KW - Sex Factors KW - Risk Factors KW - Humans KW - Geography KW - Male KW - Female KW - Drinking KW - Urinary Bladder Neoplasms -- etiology KW - Urinary Bladder Neoplasms -- epidemiology KW - Water Supply UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77891249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Bladder+cancer%2C+drinking+water+source%2C+and+tap+water+consumption%3A+a+case-control+study.&rft.au=Cantor%2C+K+P%3BHoover%2C+R%3BHartge%2C+P%3BMason%2C+T+J%3BSilverman%2C+D+T%3BAltman%2C+R%3BAustin%2C+D+F%3BChild%2C+M+A%3BKey%2C+C+R%3BMarrett%2C+L+D&rft.aulast=Cantor&rft.aufirst=K&rft.date=1987-12-01&rft.volume=79&rft.issue=6&rft.spage=1269&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-17 N1 - Date created - 1988-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - NIH conference. Alcohol withdrawal and noradrenergic function. AN - 77880919; 2825572 AB - Alcohol withdrawal syndrome is characterized by signs of overactivity of the sympathetic nervous system. Biochemical studies indicate that increased release of norepinephrine is associated with certain symptoms of alcohol withdrawal, and the severity of the withdrawal symptoms correlates positively with the amount of norepinephrine released. In the rat, the brain epinephrine concentration is reduced by alcohol, a phenomenon probably associated with both the intoxicating and rewarding effects of alcohol intake. Furthermore, intoxicating effects of alcohol can be reversed by inhibiting epinephrine synthesis in the rat brain. In this species, alcohol withdrawal is associated with profound depletion of epinephrine in the hypothalamus. When clonidine, a norepinephrine alpha-2-receptor agonist, was infused in alcoholics, these receptors were found to be subsensitive during alcohol withdrawal, and this subsensitivity may contribute to the syndrome. Repeated withdrawals may lead to "kindling" and thus further enhancement of noradrenergic overactivity. Pituitary responsiveness to corticotropin-releasing hormone, which is a central regulator of stress responses and increases the firing rate of brain noradrenergic neurons, is altered during alcohol withdrawal. JF - Annals of internal medicine AU - Linnoila, M AU - Mefford, I AU - Nutt, D AU - Adinoff, B AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 875 EP - 889 VL - 107 IS - 6 SN - 0003-4819, 0003-4819 KW - Receptors, Adrenergic, alpha KW - 0 KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Clonidine KW - MN3L5RMN02 KW - Norepinephrine KW - X4W3ENH1CV KW - Epinephrine KW - YKH834O4BH KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Kindling, Neurologic KW - Hypothalamo-Hypophyseal System -- physiopathology KW - Humans KW - Brain Chemistry -- drug effects KW - Pituitary-Adrenal System -- physiopathology KW - Receptors, Adrenergic, alpha -- physiology KW - Epinephrine -- metabolism KW - Epinephrine -- physiology KW - Norepinephrine -- physiology KW - Substance Withdrawal Syndrome -- physiopathology KW - Substance Withdrawal Syndrome -- metabolism KW - Norepinephrine -- metabolism KW - Sympathetic Nervous System -- physiopathology KW - Alcoholism -- metabolism KW - Alcoholism -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77880919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=NIH+conference.+Alcohol+withdrawal+and+noradrenergic+function.&rft.au=Linnoila%2C+M%3BMefford%2C+I%3BNutt%2C+D%3BAdinoff%2C+B&rft.aulast=Linnoila&rft.aufirst=M&rft.date=1987-12-01&rft.volume=107&rft.issue=6&rft.spage=875&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-07 N1 - Date created - 1988-01-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of the lower respiratory tract inflammation of nonsmoking individuals with interstitial lung disease associated with chronic inhalation of inorganic dusts. AN - 77880621; 2825569 AB - The pneumoconioses, interstitial lung disorders resulting from the inhalation of inorganic dusts, are associated with chronic inflammatory processes in the lower respiratory tract. To characterize these inflammatory processes in relation to the pathogenesis of these disorders, we studied 39 nonsmoking individuals with long-term occupational exposures to inorganic dust and functional evidence of interstitial disease (asbestosis, n = 18; coal workers' pneumoconiosis, n = 15; silicosis, n = 6). In all 3 disorders, the inflammation was dominated by alveolar macrophages. Because a common feature of these interstitial lung diseases is concurrent injury and fibrosis of alveolar walls, we assessed whether these alveolar macrophages were spontaneously releasing mediators capable of giving rise to these changes. Alveolar macrophages from the study population were spontaneously releasing increased amounts of superoxide anion and hydrogen peroxide (both p less than 0.01 compared to normals), oxidants capable of injuring lung parenchymal cells. The alveolar macrophages were also spontaneously releasing significantly increased amounts of fibronectin and alveolar macrophage-derived growth factor (both p less than 0.01 compared to normals), mediators that act synergistically to signal fibroblast replication. Taken together, these findings define a major role for the alveolar macrophage in mediating the alveolar wall injury and fibrosis that characterize the common pneumoconioses and suggest that the alveolar macrophage is an important "target" for developing strategies designed to prevent loss of lung function in these individuals. JF - The American review of respiratory disease AU - Rom, W N AU - Bitterman, P B AU - Rennard, S I AU - Cantin, A AU - Crystal, R G AD - Pulmonary Branch. National Heart, Lung, and Blood Institute, Bethesda, MD 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1429 EP - 1434 VL - 136 IS - 6 SN - 0003-0805, 0003-0805 KW - Fibronectins KW - 0 KW - Gallium Radioisotopes KW - Growth Substances KW - Peptides KW - alveolar macrophage growth factor KW - Superoxides KW - 11062-77-4 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Abridged Index Medicus KW - Index Medicus KW - Silicosis -- metabolism KW - Silicosis -- diagnostic imaging KW - Lung -- diagnostic imaging KW - Humans KW - Hydrogen Peroxide -- metabolism KW - Fibronectins -- metabolism KW - Asbestosis -- metabolism KW - Growth Substances -- metabolism KW - Asbestosis -- etiology KW - Radionuclide Imaging KW - Asbestosis -- diagnostic imaging KW - Bronchoalveolar Lavage Fluid -- metabolism KW - Superoxides -- metabolism KW - Pulmonary Alveoli -- metabolism KW - Adult KW - Middle Aged KW - Bronchoalveolar Lavage Fluid -- cytology KW - Silicosis -- etiology KW - Male KW - Female KW - Macrophages -- metabolism KW - Smoking KW - Pneumoconiosis -- diagnostic imaging KW - Pulmonary Fibrosis -- etiology KW - Pulmonary Fibrosis -- diagnostic imaging KW - Pneumoconiosis -- etiology KW - Pneumoconiosis -- metabolism KW - Pulmonary Fibrosis -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77880621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Characterization+of+the+lower+respiratory+tract+inflammation+of+nonsmoking+individuals+with+interstitial+lung+disease+associated+with+chronic+inhalation+of+inorganic+dusts.&rft.au=Rom%2C+W+N%3BBitterman%2C+P+B%3BRennard%2C+S+I%3BCantin%2C+A%3BCrystal%2C+R+G&rft.aulast=Rom&rft.aufirst=W&rft.date=1987-12-01&rft.volume=136&rft.issue=6&rft.spage=1429&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-05 N1 - Date created - 1988-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of transforming growth factor-beta in the development of the mouse embryo. AN - 77879474; 3320058 AB - Using immunohistochemical methods, we have investigated the role of transforming growth factor-beta (TGF-beta) in the development of the mouse embryo. For detection of TGF-beta in 11-18-d-old embryos, we have used a polyclonal antibody specific for TGF-beta type 1 and the peroxidase-antiperoxidase technique. Staining of TGF-beta is closely associated with mesenchyme per se or with tissues derived from mesenchyme, such as connective tissue, cartilage, and bone. TGF-beta is conspicuous in tissues derived from neural crest mesenchyme, such as the palate, larynx, facial mesenchyme, nasal sinuses, meninges, and teeth. Staining of all of these tissues is greatest during periods of morphogenesis. In many instances, intense staining is seen in mesenchyme when critical interactions with adjacent epithelium occur, as in the development of hair follicles, teeth, and the submandibular gland. Marked staining is also seen when remodeling of mesenchyme or mesoderm occurs, as during formation of digits from limb buds, formation of the palate, and formation of the heart valves. The presence of TGF-beta is often coupled with pronounced angiogenic activity. The histochemical results are discussed in terms of the known biochemical actions of TGF-beta, especially its ability to control both synthesis and degradation of both structural and adhesion molecules of the extracellular matrix. JF - The Journal of cell biology AU - Heine, U AU - Munoz, E F AU - Flanders, K C AU - Ellingsworth, L R AU - Lam, H Y AU - Thompson, N L AU - Roberts, A B AU - Sporn, M B AD - Laboratory of Comparative Carcinogenesis and Program Resources, Inc., National Cancer Institute-Frederick Cancer Research Facility, Maryland 21701. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 2861 EP - 2876 VL - 105 IS - 6 Pt 2 SN - 0021-9525, 0021-9525 KW - Fixatives KW - 0 KW - Peptides KW - RNA, Messenger KW - Transforming Growth Factors KW - 76057-06-2 KW - Index Medicus KW - Animals KW - RNA, Messenger -- metabolism KW - Connective Tissue -- metabolism KW - Meninges -- metabolism KW - Heart -- embryology KW - Mesoderm -- metabolism KW - Bone and Bones -- metabolism KW - Myocardium -- metabolism KW - Immunoenzyme Techniques KW - Meninges -- embryology KW - Bone and Bones -- embryology KW - Mice -- embryology KW - Peptides -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77879474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+cell+biology&rft.atitle=Role+of+transforming+growth+factor-beta+in+the+development+of+the+mouse+embryo.&rft.au=Heine%2C+U%3BMunoz%2C+E+F%3BFlanders%2C+K+C%3BEllingsworth%2C+L+R%3BLam%2C+H+Y%3BThompson%2C+N+L%3BRoberts%2C+A+B%3BSporn%2C+M+B&rft.aulast=Heine&rft.aufirst=U&rft.date=1987-12-01&rft.volume=105&rft.issue=6+Pt+2&rft.spage=2861&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+cell+biology&rft.issn=00219525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Natl Cancer Inst Monogr. 1967 Sep;26:279-99 [4864107] Mol Cell Biol. 1985 Dec;5(12):3644-6 [3870134] Eur J Biochem. 1980 Jun;107(2):303-14 [6772444] Cell Tissue Res. 1980;211(2):269-91 [6998561] Science. 1981 Jul 31;213(4507):563-5 [7017936] Ann N Y Acad Sci. 1981 Feb 27;359:200-17 [6266308] EMBO J. 1986 Aug;5(8):1831-7 [3758028] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8206-10 [3022285] J Biol Chem. 1986 Dec 15;261(35):16509-13 [3465726] J Cell Biol. 1986 Nov;103(5):1799-805 [3465734] J Cell Biol. 1986 Dec;103(6 Pt 1):2403-10 [3491081] J Exp Med. 1987 Jan 1;165(1):251-6 [3491869] Nature. 1987 Jan 1-7;325(6099):81-4 [3467201] Cell. 1987 Feb 13;48(3):409-15 [2879635] Cell Biol Int Rep. 1986 Dec;10(12):915-22 [3467860] J Biol Chem. 1987 Feb 15;262(5):1946-9 [3469199] J Biol Chem. 1987 Feb 25;262(6):2869-74 [3469200] J Biol Chem. 1987 Mar 15;262(8):3897-902 [3493244] Nucleic Acids Res. 1987 Apr 10;15(7):3187 [3470708] Proc Natl Acad Sci U S A. 1987 Apr;84(7):2024-8 [3494250] Cell. 1987 May 22;49(4):437-8 [3471351] J Biol Chem. 1987 May 15;262(14):6443-6 [3471760] J Cell Biol. 1987 May;104(5):1361-74 [3553211] Nature. 1987 Jun 18-24;327(6123):625-8 [3600758] Biochemistry. 1987 May 5;26(9):2406-10 [3475130] EMBO J. 1987 May;6(5):1281-6 [3111844] EMBO J. 1987 Jun;6(6):1633-6 [3497030] J Cell Biol. 1987 Jul;105(1):457-63 [3475276] J Cell Biol. 1987 Jul;105(1):473-82 [2440898] Proc Natl Acad Sci U S A. 1987 Aug;84(16):5788-92 [2886992] EMBO J. 1987 Jul;6(7):1899-904 [2820711] J Cell Biol. 1987 Sep;105(3):1039-45 [3308901] Cell. 1987 Oct 23;51(2):189-97 [3499229] Mol Endocrinol. 1987 Oct;1(10):693-8 [3153459] Cell. 1981 Oct;26(1 Pt 1):99-105 [7034958] J Cell Physiol. 1982 Feb;110(2):169-74 [6279682] Dev Biol. 1982 Aug;92(2):315-29 [7117690] Science. 1983 Mar 18;219(4590):1329-31 [6572416] J Cell Biol. 1983 Feb;96(2):462-73 [6833366] Cancer Res. 1983 Jul;43(7):3034-40 [6189589] J Biol Chem. 1983 Jun 10;258(11):7155-60 [6602130] J Cell Biol. 1983 Jul;97(1):153-65 [6190818] Cell. 1984 Jan;36(1):35-41 [6319010] Dev Biol. 1984 Feb;101(2):336-45 [6363163] Cancer Res. 1984 Apr;44(4):1635-41 [6322983] Proc Natl Acad Sci U S A. 1985 Apr;82(8):2267-71 [3857579] Nature. 1985 Aug 22-28;316(6030):701-5 [3861940] Adv Cancer Res. 1985;44:139-266 [2930999] J Histochem Cytochem. 1986 Jan;34(1):85-91 [2416801] J Biol Chem. 1986 Mar 25;261(9):4337-45 [3456347] J Biol Chem. 1986 Apr 5;261(10):4377-9 [3007454] J Biol Chem. 1986 May 5;261(13):5693-5 [3754555] J Cell Biol. 1986 May;102(5):1917-30 [2422181] J Embryol Exp Morphol. 1985 Dec;90:437-55 [3834038] Proc Natl Acad Sci U S A. 1986 Jun;83(12):4167-71 [2424019] Science. 1986 Aug 1;233(4763):532-4 [3487831] J Biol Chem. 1986 Aug 15;261(23):10478-81 [3488314] Biochem Biophys Res Commun. 1986 Jul 31;138(2):974-80 [3461787] J Biol Chem. 1986 Sep 15;261(26):12362-7 [3528157] Cell. 1976 Oct;9(2):231-40 [975245] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neuroleptic responsivity of negative and positive symptoms in schizophrenia. AN - 77874369; 3688278 AB - The authors prospectively examined the effects of double-blind, placebo-controlled neuroleptic withdrawal and administration on ratings of negative and positive symptoms in 19 young patients with chronic schizophrenia. Negative symptoms were significantly reduced by neuroleptic treatment, and negative and positive symptoms demonstrated similar patterns of reduction and exacerbation during neuroleptic treatment and withdrawal, respectively. The changes in negative and positive symptoms induced by neuroleptic treatment and withdrawal were not significantly correlated, however. The negative and positive symptom profiles of individual patients were significantly altered by neuroleptic treatment, indicating limitations to the cross-sectional classification of patients on the basis of predominance of one or the other symptom group. The authors discuss implications for the neurobiological underpinnings of negative and positive symptoms. JF - The American journal of psychiatry AU - Breier, A AU - Wolkowitz, O M AU - Doran, A R AU - Roy, A AU - Boronow, J AU - Hommer, D W AU - Pickar, D AD - Section on Clinical Studies, NIMH, Bethesda, Md. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1549 EP - 1555 VL - 144 IS - 12 SN - 0002-953X, 0002-953X KW - Placebos KW - 0 KW - Fluphenazine KW - S79426A41Z KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Dopamine -- physiology KW - Brain -- physiopathology KW - Prospective Studies KW - Psychiatric Status Rating Scales KW - Substance Withdrawal Syndrome -- etiology KW - Adult KW - Substance Withdrawal Syndrome -- psychology KW - Chronic Disease KW - Female KW - Male KW - Fluphenazine -- adverse effects KW - Schizophrenia -- diagnosis KW - Fluphenazine -- therapeutic use KW - Schizophrenic Psychology KW - Schizophrenia -- drug therapy KW - Fluphenazine -- administration & dosage KW - Schizophrenia -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77874369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Neuroleptic+responsivity+of+negative+and+positive+symptoms+in+schizophrenia.&rft.au=Breier%2C+A%3BWolkowitz%2C+O+M%3BDoran%2C+A+R%3BRoy%2C+A%3BBoronow%2C+J%3BHommer%2C+D+W%3BPickar%2C+D&rft.aulast=Breier&rft.aufirst=A&rft.date=1987-12-01&rft.volume=144&rft.issue=12&rft.spage=1549&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-30 N1 - Date created - 1987-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Obsessive-compulsive symptoms in panic disorder. AN - 77873249; 3688281 AB - Previous reports have noted an increased prevalence of obsessive-compulsive symptoms in patients with panic disorder. The authors found a prevalence of obsessive-compulsive symptoms in 19 (27%) of 70 patients with panic disorder. Compared to a subgroup of 25 patients with classic features of panic disorder and no obsessive-compulsive symptoms, the subgroup with obsessive-compulsive symptoms had an earlier onset of illness, were more likely to have personal and family histories of major depression and substance abuse, and showed a poorer outcome after treatment. JF - The American journal of psychiatry AU - Mellman, T A AU - Uhde, T W AD - Unit on Anxiety and Affective Disorders, NIMH, Bethesda, MD 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1573 EP - 1576 VL - 144 IS - 12 SN - 0002-953X, 0002-953X KW - Abridged Index Medicus KW - Index Medicus KW - Substance-Related Disorders -- diagnosis KW - Psychiatric Status Rating Scales KW - Alcoholism -- diagnosis KW - Humans KW - Adult KW - Outcome and Process Assessment (Health Care) KW - Depressive Disorder -- diagnosis KW - Depressive Disorder -- genetics KW - Alcoholism -- genetics KW - Substance-Related Disorders -- genetics KW - Male KW - Female KW - Obsessive-Compulsive Disorder -- diagnosis KW - Fear KW - Anxiety Disorders -- psychology KW - Obsessive-Compulsive Disorder -- psychology KW - Obsessive-Compulsive Disorder -- complications KW - Anxiety Disorders -- diagnosis KW - Panic KW - Anxiety Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77873249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Obsessive-compulsive+symptoms+in+panic+disorder.&rft.au=Mellman%2C+T+A%3BUhde%2C+T+W&rft.aulast=Mellman&rft.aufirst=T&rft.date=1987-12-01&rft.volume=144&rft.issue=12&rft.spage=1573&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-30 N1 - Date created - 1987-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Radiation dose and leukemia risk in patients treated for cancer of the cervix. AN - 77870107; 3480381 AB - To quantify the risk of radiation-induced leukemia and provide further information on the nature of the relationship between dose and response, a case-control study was undertaken in a cohort of over 150,000 women with invasive cancer of the uterine cervix. The cases either were reported to one of 17 population-based cancer registries or were treated in any of 16 oncologic clinics in Canada, Europe, and the United States. Four controls were individually matched to each of 195 cases of leukemia on the basis of age and calendar year when diagnosed with cervical cancer and survival time. Leukemia diagnoses were verified by one hematologist. Radiation dose to active bone marrow was estimated by medical physicists on the basis of the original radiotherapy records of study subjects. The risk of chronic lymphocytic leukemia, one of the few malignancies without evidence for an association with ionizing radiation, was not increased [relative risk (RR) = 1.03; n = 52]. However, for all other forms of leukemia taken together (n = 143), a twofold risk was evident (RR = 2.0; 90% confidence interval = 1.0-4.2). Risk increased with increasing radiation dose until average doses of about 400 rad (4 Gy) were reached and then decreased at higher doses. This pattern is consistent with experimental data for which the down-turn in risk at high doses has been interpreted as due to killing of potentially leukemic cells. The dose-response information was modeled with various RR functions, accounting for the nonhomogeneous distribution of radiation dose during radiotherapy. The local radiation doses to each of 14 bone marrow compartments for each patient were incorporated in the models, and the corresponding risks were summed. A good fit to the observed data was obtained with a linear-exponential function, which included a positive linear induction term and a negative exponential term. The estimate of the excess RR per rad was 0.9%, and the estimated RR at 100 rad (1 Gy) was 1.7. The model proposed in this study of risk proportional to mass exposed and of risk to an individual given by the sum of incremental risks to anatomic sites appears to be applicable to a wide range of dose distributions. Furthermore, the pattern of leukemia incidence associated with different levels of radiation dose is consistent with a model postulating increasing risk with increasing exposure, modified at high doses by increased frequency of cell death, which reduces risk. JF - Journal of the National Cancer Institute AU - Boice, J D AU - Blettner, M AU - Kleinerman, R A AU - Stovall, M AU - Moloney, W C AU - Engholm, G AU - Austin, D F AU - Bosch, A AU - Cookfair, D L AU - Krementz, E T AU - Latourette, H B AU - Peters, L J AU - Schulz, M D AU - Lundell, M AU - Pettersson, F AU - Storm, H H AU - Bell, C M AU - Coleman, M P AU - Fraser, P AU - Palmer, M AU - Prior, P AU - Choi, N W AU - Hislop, T G AU - Koch, M AU - Robb, D AU - Robson, D AU - Spengler, R F AU - von Fournier, D AU - Frischkorn, R AU - Lochmüller, H AU - Pompe-Kirn, V AU - Rimpela, A AU - Kjørstad, K AU - Pejovic, M H AU - Sigurdsson, K AU - Pisani, P AU - Kucera, H AU - Hutchison, G B AD - Radiation Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1295 EP - 1311 VL - 79 IS - 6 SN - 0027-8874, 0027-8874 KW - Index Medicus KW - United States KW - Age Factors KW - Brachytherapy -- adverse effects KW - Humans KW - Aged KW - Europe KW - Registries KW - Radiotherapy Dosage KW - Risk Factors KW - Adult KW - Middle Aged KW - Bone Marrow -- radiation effects KW - Female KW - Leukemia, Radiation-Induced -- etiology KW - Uterine Cervical Neoplasms -- radiotherapy KW - Radiotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77870107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Radiation+dose+and+leukemia+risk+in+patients+treated+for+cancer+of+the+cervix.&rft.au=Boice%2C+J+D%3BBlettner%2C+M%3BKleinerman%2C+R+A%3BStovall%2C+M%3BMoloney%2C+W+C%3BEngholm%2C+G%3BAustin%2C+D+F%3BBosch%2C+A%3BCookfair%2C+D+L%3BKrementz%2C+E+T%3BLatourette%2C+H+B%3BPeters%2C+L+J%3BSchulz%2C+M+D%3BLundell%2C+M%3BPettersson%2C+F%3BStorm%2C+H+H%3BBell%2C+C+M%3BColeman%2C+M+P%3BFraser%2C+P%3BPalmer%2C+M%3BPrior%2C+P%3BChoi%2C+N+W%3BHislop%2C+T+G%3BKoch%2C+M%3BRobb%2C+D%3BRobson%2C+D%3BSpengler%2C+R+F%3Bvon+Fournier%2C+D%3BFrischkorn%2C+R%3BLochm%C3%BCller%2C+H%3BPompe-Kirn%2C+V%3BRimpela%2C+A%3BKj%C3%B8rstad%2C+K%3BPejovic%2C+M+H%3BSigurdsson%2C+K%3BPisani%2C+P%3BKucera%2C+H%3BHutchison%2C+G+B&rft.aulast=Boice&rft.aufirst=J&rft.date=1987-12-01&rft.volume=79&rft.issue=6&rft.spage=1295&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-17 N1 - Date created - 1988-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The neostriatal mosaic: III. Biochemical and developmental dissociation of patch-matrix mesostriatal systems. AN - 77866567; 2891800 AB - In the previous paper (Gerfen et al., 1987) mesostriatal dopaminergic neurons were shown to be subdivided into dorsal and ventral tiers that project to the striatal matrix and patch compartments, respectively. The present study provides experimental evidence that these patch-matrix mesostriatal dopaminergic systems are biochemically and developmentally distinct. A 28 kDa calcium-binding protein (CaBP, or calbindin-D28 kDa) is expressed in dorsal tier mesostriatal dopaminergic neurons. The distribution of such neurons, located in the ventral tegmental area, dorsal tier of the substantia nigra pars compacta, and retrorubral area, matches that of dopaminergic neurons that project to the striatal matrix. Dopaminergic neurons that do not express CaBP--those in the ventral tier of the pars compacta and in the pars reticulata--are distributed in a pattern that matches the origin of the dopaminergic projection to the striatal patches. During development, dopaminergic afferents to the striatal patch compartment are in place prior to the development of those to the matrix. Injections of the neurotoxin 6-hydroxydopamine (6-OHDA) into the striatum of newborn rats result in a selective and long-lasting depletion of dopaminergic afferents in the striatal patches. The later-developing matrix projection is relatively spared by such lesions. The distribution of surviving dopaminergic neurons, labeled with tyrosine hydroxylase (TH) immunoreactivity, matches the pattern of dorsal tier neurons previously shown to provide inputs to the matrix. Surviving neurons also express CaBP immunoreactivity and have dendrites that spread mediolaterally, in the plane of the pars compacta. On the other hand, those neurons that project to the patches are selectively lesioned by the neonatal 6-OHDA striatal injections, do not express CaBP, and have dendrites that are directed ventrally into the pars reticulata. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Gerfen, C R AU - Baimbridge, K G AU - Thibault, J AD - Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 3935 EP - 3944 VL - 7 IS - 12 SN - 0270-6474, 0270-6474 KW - Calbindins KW - 0 KW - Hydroxydopamines KW - S100 Calcium Binding Protein G KW - Oxidopamine KW - 8HW4YBZ748 KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Tyrosine 3-Monooxygenase -- analysis KW - Animals KW - Neural Pathways -- analysis KW - Brain Diseases -- physiopathology KW - Neural Pathways -- cytology KW - Corpus Striatum -- cytology KW - Mesencephalon -- analysis KW - Dopamine -- analysis KW - Mesencephalon -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77866567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=The+neostriatal+mosaic%3A+III.+Biochemical+and+developmental+dissociation+of+patch-matrix+mesostriatal+systems.&rft.au=Gerfen%2C+C+R%3BBaimbridge%2C+K+G%3BThibault%2C+J&rft.aulast=Gerfen&rft.aufirst=C&rft.date=1987-12-01&rft.volume=7&rft.issue=12&rft.spage=3935&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-28 N1 - Date created - 1988-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases. AN - 77866507; 2961314 AB - Sixty-four patients were entered into a randomized trial that evaluated intra-arterial (I.A.) versus intravenous (I.V.) 5-fluorodeoxyuridine (FUDR) for colorectal liver metastases. There was a significant improved response rate for I.A. (62%) compared with I.V. (17%) treatment (p less than 0.003). However, the improved response rate for patients in whom I.A. therapy was used did not translate to a significantly improved survival rate. The 2-year actuarial survival rates for the groups for which I.A. and I.V. therapy was used were 22% and 15% respectively, with the survival curves not differing significantly (p = 0.27). These results may have been due to the inclusion of patients with tumor in draining hepatic lymph nodes. The presence of tumor in hepatic lymph nodes was associated with a poorer prognosis. Analysis of a subgroup of patients with negative hepatic lymph nodes suggested an improved actuarial survival rate in patients for whom I.A. versus I.V. therapy was used (p less than 0.03). The toxicity of I.A. FUDR was considerable, and side effects included chemical hepatitis (79%), biliary sclerosis (21%), peptic ulcers (17%), and gastritis/duodenitis (21%). The only major effect of toxicity of I.V. FUDR was severe diarrhea (59%). Regional I.A. FUDR allowed more drug delivery to liver tumors, which resulted in increased tumor responses when compared with use of systemic therapy. However, the small gain in survival seen in a select subgroup of patients with negative hepatic nodes appeared to be offset by the toxicity of I.A. FUDR. JF - Annals of surgery AU - Chang, A E AU - Schneider, P D AU - Sugarbaker, P H AU - Simpson, C AU - Culnane, M AU - Steinberg, S M AD - Surgery Branch, National Cancer Institute, Bethesda, Maryland. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 685 EP - 693 VL - 206 IS - 6 SN - 0003-4932, 0003-4932 KW - Floxuridine KW - 039LU44I5M KW - Abridged Index Medicus KW - Index Medicus KW - Prospective Studies KW - Infusions, Intravenous KW - Random Allocation KW - Lymphatic Metastasis KW - Humans KW - Adult KW - Tomography, X-Ray Computed KW - Prognosis KW - Aged KW - Middle Aged KW - Male KW - Female KW - Floxuridine -- administration & dosage KW - Liver Neoplasms -- pathology KW - Infusions, Intra-Arterial KW - Rectal Neoplasms KW - Liver Neoplasms -- drug therapy KW - Liver Neoplasms -- secondary KW - Colonic Neoplasms KW - Floxuridine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77866507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+surgery&rft.atitle=A+prospective+randomized+trial+of+regional+versus+systemic+continuous+5-fluorodeoxyuridine+chemotherapy+in+the+treatment+of+colorectal+liver+metastases.&rft.au=Chang%2C+A+E%3BSchneider%2C+P+D%3BSugarbaker%2C+P+H%3BSimpson%2C+C%3BCulnane%2C+M%3BSteinberg%2C+S+M&rft.aulast=Chang&rft.aufirst=A&rft.date=1987-12-01&rft.volume=206&rft.issue=6&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Annals+of+surgery&rft.issn=00034932&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-04 N1 - Date created - 1988-01-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Chemother Rep. 1966 Mar;50(3):163-70 [5910392] N Engl J Med. 1964 Feb 13;270:321-7 [14082260] Surg Gynecol Obstet. 1972 Jan;134(1):51-6 [5007175] Cancer Res. 1978 Nov;38(11 Pt 1):3784-92 [151583] Surgery. 1979 Oct;86(4):550-5 [384574] Cancer. 1980 Mar 1;45(5):866-9 [7260838] Cancer. 1982 Sep 1;50(5):850-62 [6212114] Am J Surg. 1983 Apr;145(4):529-33 [6220618] Semin Oncol. 1983 Jun;10(2):135-47 [6306833] Ann Surg. 1983 Nov;198(5):567-73 [6227295] Cancer. 1984 Mar 15;53(6):1336-43 [6229326] Cancer Invest. 1983;1(3):237-57 [6365269] J Clin Oncol. 1983 May;1(5):337-44 [6199474] Ann Surg. 1984 Mar;199(3):317-24 [6703793] J Clin Oncol. 1984 May;2(5):498-504 [6547166] J Clin Oncol. 1984 Jun;2(6):595-600 [6233400] J Clin Oncol. 1985 Jan;3(1):98-102 [3155548] J Clin Oncol. 1985 Feb;3(2):161-9 [3155793] Cancer. 1985 Apr 1;55(7):1490-4 [3978541] Ann Surg. 1985 Aug;202(2):176-81 [3160313] Int J Radiat Oncol Biol Phys. 1985 Nov;11(11):1941-6 [2997090] Recent Results Cancer Res. 1986;100:171-8 [2942993] J Clin Oncol. 1986 Sep;4(9):1356-64 [2943876] Surgery. 1987 Jul;102(1):79-87 [3589978] Am J Pathol. 1954 Sep-Oct;30(5):969-77 [13197542] Surgery. 1970 Aug;68(2):334-40 [5450714] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cytogenetic and environmental factors in the etiology of the acute leukemias in adults. AN - 77858242; 3318409 JF - American journal of epidemiology AU - Sandler, D P AU - Collman, G W AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1017 EP - 1032 VL - 126 IS - 6 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Acute Disease KW - Risk Factors KW - Humans KW - Adult KW - Environmental Exposure KW - Chromosome Aberrations KW - Leukemia -- epidemiology KW - Leukemia -- etiology KW - Leukemia -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77858242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Cytogenetic+and+environmental+factors+in+the+etiology+of+the+acute+leukemias+in+adults.&rft.au=Sandler%2C+D+P%3BCollman%2C+G+W&rft.aulast=Sandler&rft.aufirst=D&rft.date=1987-12-01&rft.volume=126&rft.issue=6&rft.spage=1017&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-07 N1 - Date created - 1988-01-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Heterogeneity of intercellular adhesion in rat liver cells in culture. AN - 77853150; 3691677 AB - The intercellular homotypic adhesive properties of 14 clones derived from a nontumorigenic rat liver epithelial cell line (LEC), derived from neonatal Fischer rats, were examined and compared to those of the hepatoma H4-II-E cell line. Each clone was assayed also for the degree of chromosomal aneuploidy and the ability to grow in soft agar. Over 100-fold differences in adhesive properties were observed among the clones, but no correlation was observed between the degree of aneuploidy in the clones and intercellular adhesive properties. The parent LEC cell line and the clones derived from it were unable to grow in soft agar. The H4-II-E cells showed negligible capacity to reaggregate after dissociation into single cells and these cells readily formed colonies in soft agar. Many of the LEC clones were similar to the H4-II-E cells in their adhesive properties, which suggests that reduced cell-to-cell adhesiveness per se is not a necessary prerequisite of epithelial cells to be able to grow independent of anchorage. Two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) of concanavalin A (Con A)-binding glycoproteins in the "most adhesive" clone 67 and the "least adhesive" clone 201 showed markedly elevated amounts of acidic 105 and 67-kDa glycoproteins in clone 67. Proteins with similar migration patterns in 2D-PAGE have previously been reported to participate in specific homotypic intercellular adhesion of liver cells. The Con A-binding glycoprotein pattern in H4-II-E cells was markedly different from that of LEC cells with a set of six proteins missing and nine proteins appearing new in the H4-II-E cells. It is suggested that, in addition to identifying known epithelial cell polypeptides, systematic screening of cell surface-associated glycoproteins in normal and transformed epithelial cells in vitro and in vivo may lead to identification of novel polypeptides intimately associated with the transformed phenotype. JF - Experimental cell research AU - Raunio, H AU - Konno, R AU - Linnainmaa, K AU - Wirth, P J AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 596 EP - 605 VL - 173 IS - 2 SN - 0014-4827, 0014-4827 KW - Glycoproteins KW - 0 KW - Receptors, Concanavalin A KW - concanavalin A-binding glycoproteins KW - Index Medicus KW - Animals KW - Receptors, Concanavalin A -- classification KW - Aneuploidy KW - Glycoproteins -- analysis KW - Electrophoresis, Polyacrylamide Gel KW - Glycoproteins -- classification KW - Clone Cells -- classification KW - Rats KW - Rats, Inbred F344 KW - Chromosomes KW - Clone Cells -- physiology KW - Receptors, Concanavalin A -- analysis KW - Cell Aggregation KW - Cell Line KW - Male KW - Cell Division KW - Liver -- cytology KW - Cell Communication KW - Cell Adhesion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77853150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+cell+research&rft.atitle=Heterogeneity+of+intercellular+adhesion+in+rat+liver+cells+in+culture.&rft.au=Raunio%2C+H%3BKonno%2C+R%3BLinnainmaa%2C+K%3BWirth%2C+P+J%3BThorgeirsson%2C+S+S&rft.aulast=Raunio&rft.aufirst=H&rft.date=1987-12-01&rft.volume=173&rft.issue=2&rft.spage=596&rft.isbn=&rft.btitle=&rft.title=Experimental+cell+research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-02 N1 - Date created - 1988-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Idiopathic dilated cardiomyopathy: analysis of 152 necropsy patients. AN - 77851571; 3687784 AB - Certain clinical and cardiac necropsy findings are described in 152 patients aged 16 to 78 years (mean 45) with idiopathic dilated cardiomyopathy: 109 (72%) were men and 43 (28%) were women. Compared with the women, the men had a significantly (p less than 0.05) shorter mean duration of chronic congestive heart failure (CHF) (43 vs 69 months), a higher percentage of habitual alcoholism (40 vs 24%) and a higher mean heart weight (632 vs 551 g). The male to female ratio among the 58 known alcoholics was 7.3:1 and among the 70 known nonalcoholics, 1.5:1 (p less than 0.05). The mean duration of clinical evidence of CHF was similar among the known alcoholics and the known non-alcoholics (each 50 months). Of the 152 patients, 148 (97%) had clinical evidence of chronic CHF; in 114 patients it was the initial manifestation of idiopathic dilated cardiomyopathy, and in most it became intractable and caused death. The interval from onset of chronic CHF to death (known in 120 patients) ranged from 1 to 264 months (mean 54). Comparison of the 27 patients surviving greater than 72 months after onset of chronic CHF to the 64 patients surviving less than or equal to 36 months disclosed a significantly higher frequency in the longer survival group of older patients, of women, of habitual alcoholics, of patients with chest pain syndromes, diabetes mellitus, pulmonary emboli, of patients treated with warfarin and of patients with larger hearts at necropsy. Each of the 4 patients without chronic CHF died suddenly and sudden death was the initial manifestation of idiopathic dilated cardiomyopathy in them. An additional 33 patients also died suddenly, but each of them previously had had chronic CHF. Of the 79 patients (of the 131 for whom information was available) with either pulmonary or systemic emboli or both, 67 (85%) had either right- or left-sided thrombi or mural endocardial plaques or both, whereas of the 52 patients without emboli, 36 (69%) had intracardiac thrombi or plaques (p less than (0.05). Electrocardiograms in the last 6 months of life in 101 patients disclosed atrial fibrillation in 25; complete left (41 patients) or right (6 patients) bundle branch block or indeterminate intraventricular conduction delay (4 patients) in 51 patients; QRS voltage indicative of ventricular hypertrophy in 44 patients (left ventricular in 39 patients.(ABSTRACT TRUNCATED AT 400 WORDS) JF - The American journal of cardiology AU - Roberts, W C AU - Siegel, R J AU - McManus, B M AD - Pathology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892. Y1 - 1987/12/01/ PY - 1987 DA - 1987 Dec 01 SP - 1340 EP - 1355 VL - 60 IS - 16 SN - 0002-9149, 0002-9149 KW - Abridged Index Medicus KW - Index Medicus KW - Heart Failure -- etiology KW - Pregnancy Complications KW - Embolism -- complications KW - Myocardium -- pathology KW - Humans KW - Hemodynamics KW - Aged KW - Heart Diseases -- complications KW - Organ Size KW - Pregnancy KW - Death, Sudden -- etiology KW - Electrocardiography KW - Adult KW - Heart Diseases -- genetics KW - Middle Aged KW - Adolescent KW - Alcoholism -- complications KW - Male KW - Diabetes Complications KW - Female KW - Cardiomyopathy, Dilated -- physiopathology KW - Cardiomyopathy, Dilated -- complications KW - Cardiomyopathy, Dilated -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77851571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Idiopathic+dilated+cardiomyopathy%3A+analysis+of+152+necropsy+patients.&rft.au=Roberts%2C+W+C%3BSiegel%2C+R+J%3BMcManus%2C+B+M&rft.aulast=Roberts&rft.aufirst=W&rft.date=1987-12-01&rft.volume=60&rft.issue=16&rft.spage=1340&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-20 N1 - Date created - 1988-01-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid. AN - 77850570; 3319136 JF - Cancer treatment reports AU - Grem, J L AU - Hoth, D F AU - Hamilton, J M AU - King, S A AU - Leyland-Jones, B AD - Investigational Drug Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1249 EP - 1264 VL - 71 IS - 12 SN - 0361-5960, 0361-5960 KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Rectal Neoplasms -- drug therapy KW - Humans KW - Colonic Neoplasms -- drug therapy KW - Clinical Trials as Topic KW - Forecasting KW - Fluorouracil -- administration & dosage KW - Fluorouracil -- adverse effects KW - Leucovorin -- administration & dosage KW - Leucovorin -- adverse effects KW - Leucovorin -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Leucovorin -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77850570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+treatment+reports&rft.atitle=Overview+of+current+status+and+future+direction+of+clinical+trials+with+5-fluorouracil+in+combination+with+folinic+acid.&rft.au=Grem%2C+J+L%3BHoth%2C+D+F%3BHamilton%2C+J+M%3BKing%2C+S+A%3BLeyland-Jones%2C+B&rft.aulast=Grem&rft.aufirst=J&rft.date=1987-12-01&rft.volume=71&rft.issue=12&rft.spage=1249&rft.isbn=&rft.btitle=&rft.title=Cancer+treatment+reports&rft.issn=03615960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-03 N1 - Date created - 1988-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Toxicological studies of chemical mixtures of environmental concern at the National Toxicology Program: health effects of groundwater contaminants. AN - 77849026; 3686528 AB - In cooperation with the Agency for Toxic Substances and Disease Registry, the National Toxicology Program is participating in a Public Health Service activity related to the Comprehensive Environmental Response, Compensation and Liability Act (Superfund Act) by conducting toxicology studies on chemicals found in high-priority hazardous waste sites and for which adequate toxicological data are not available. As part of this effort, a project on the toxicology of chemical mixtures of groundwater contaminants was initiated. The first study, centered on the health effects of groundwater contaminants, is at the contractual stage. Nineteen organic and six inorganic chemicals, selected from more than 1000 known groundwater contaminants, will be given in drinking water to Fischer 344 rats and B6C3F1 mice for 3 or 6 months. Controls and five dose levels, based on average concentrations (i.e., baseline level) of individual component chemicals, or 0.1-, 10-, or 1000-fold of the baseline level, will be used. Toxicological end points include mortality, clinical signs, water and food consumption, body and organ weights, clinical pathology analytes (e.g., hematology, clinical chemistry, and urinalysis), gross and histopathology, neurobehavioral tests, sperm morphology and vaginal cytology evaluations (SMVCE), and cytogenetics. This paper summarizes the rationale behind our experimental design and the factors one must consider when designing studies of complex chemical mixtures. JF - Toxicology AU - Yang, R S AU - Rauckman, E J AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/12/01/ PY - 1987 DA - 1987 Dec 01 SP - 15 EP - 34 VL - 47 IS - 1-2 SN - 0300-483X, 0300-483X KW - Water Pollutants KW - 0 KW - Water Pollutants, Chemical KW - Index Medicus KW - United States KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Humans KW - Nervous System -- drug effects KW - Water Supply KW - Mice KW - Male KW - Female KW - Water Pollutants -- adverse effects KW - Water Pollutants, Chemical -- adverse effects KW - National Institutes of Health (U.S.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77849026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Toxicological+studies+of+chemical+mixtures+of+environmental+concern+at+the+National+Toxicology+Program%3A+health+effects+of+groundwater+contaminants.&rft.au=Yang%2C+R+S%3BRauckman%2C+E+J&rft.aulast=Yang&rft.aufirst=R&rft.date=1987-12-01&rft.volume=47&rft.issue=1-2&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-12 N1 - Date created - 1988-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of pelvic sarcomas in adolescents and young adults with intensive combined modality therapy. AN - 77834903; 3679916 AB - Adolescent and young adult patients with pelvic sarcomas continue to have a poor prognosis with standard combination chemotherapy and local irradiation. In addition to a significant risk of local failure, these patients are at high risk for systemic relapse. Twenty-three consecutive patients with Ewing's sarcoma, alveolar rhabdomyosarcoma, undifferentiated sarcoma, or malignant peripheral neuroepithelioma originating in the pelvis were treated with short, intensive combined modality therapy. This approach integrates 5 cycles of VADRIAC chemotherapy (Vincristine, Adriamycin, Cyclophosphamide) with high dose irradiation to the primary lesion (55-60 Gy) and sites of gross metastatic disease (45-50 Gy). Following achievement of a complete response, intensification therapy consisting of total body irradiation (TBI) (8.0 Gy), high dose VADRIAC chemotherapy, and autologous bone marow transplantation is given. All therapy is completed within 6-7 months. No maintenance chemotherapy is given; no surgery is intended. Of the twenty-three patients with pelvic sarcomas treated on this combined modality protocol, 22 achieved a complete remission. Local control was achieved and maintained in all twenty-three patients. With a median follow-up of 21 months since initiation of treatment, there have been nine relapses (all systemic). Seven relapses occurred among the thirteen patients who presented with overt metastatic disease and the other two relapses were among the ten patients with localized disease at presentation. All seven metastatic patients who relapsed have died, whereas both of the relapsed localized patients remain alive. Acute and late toxicities have been acceptable using this aggressive combined modality approach. Induction chemotherapy had a significant impact on reduction of the typically large (greater than 10 cm diameter) soft tissue mass associated with these pelvic tumors, thus facilitating achievement of local control by high dose irradiation. Of 18 patients with measureable soft tissue tumor, all experienced a partial response (greater than 50% reduction in size) following the initial two cycles of chemotherapy given prior to local irradiation. In conclusion, this short, intensive chemoradiotherapeutic regimen is highly effective in controlling the primary lesion (100% local control) and inducing a complete response in a high proportion (96%) of these high risk pediatric and young adult patients with pelvic sarcomas. The role of TBI as "systemic" adjuvant therapy to control micrometastatic disease is discussed as still under investigation. JF - International journal of radiation oncology, biology, physics AU - Stea, B AU - Kinsella, T J AU - Triche, T J AU - Horvath, K AU - Glatstein, E AU - Miser, J S AD - Radiation Oncology, Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1797 EP - 1805 VL - 13 IS - 12 SN - 0360-3016, 0360-3016 KW - Index Medicus KW - Combined Modality Therapy KW - Humans KW - Adult KW - Neoplasm Metastasis KW - Adolescent KW - Sarcoma, Ewing -- therapy KW - Rhabdomyosarcoma -- therapy KW - Male KW - Female KW - Radiotherapy -- adverse effects KW - Sarcoma -- radiotherapy KW - Pelvic Neoplasms -- therapy KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Sarcoma -- drug therapy KW - Pelvic Neoplasms -- radiotherapy KW - Pelvic Neoplasms -- drug therapy KW - Sarcoma -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77834903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Treatment+of+pelvic+sarcomas+in+adolescents+and+young+adults+with+intensive+combined+modality+therapy.&rft.au=Stea%2C+B%3BKinsella%2C+T+J%3BTriche%2C+T+J%3BHorvath%2C+K%3BGlatstein%2C+E%3BMiser%2C+J+S&rft.aulast=Stea&rft.aufirst=B&rft.date=1987-12-01&rft.volume=13&rft.issue=12&rft.spage=1797&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-12 N1 - Date created - 1988-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Testicular tumors in mice exposed in utero to diethylstilbestrol. AN - 77818321; 3682076 AB - Treatment of pregnant women with diethylstilbestrol (DES) is associated with the subsequent development of reproductive tract abnormalities such as epididymal cysts, retained hypotrophic testes and sperm abnormalities in their male offspring. It recently has been suggested that prenatal DES exposure is associated with development of testicular seminoma in humans. Studies of in utero exposure of laboratory animals to DES are few, but previous reports from our laboratory have described several abnormalities in the reproductive tract of the mouse following prenatal DES exposure. To study the possible association of testicular tumors and prenatal DES exposure in mice, pregnant outbred CD-1 mice were injected subcutaneously with daily doses of DES (100 micrograms./kg.) on days nine through 16 of gestation. DES-exposed and age-matched control male mice were sacrificed at 10 to 18 months of age and examined for testicular lesions. In addition to the nonmalignant abnormalities reported in previous studies such as 91% cryptorchidism and degenerative changes, interstitial cell tumors were observed in nine mice among 277 mice treated prenatally with DES. Two of these lesions were benign tumors and five were interstitial cell carcinomas. Rete testis adenocarcinoma was seen also in 5% of these DES-treated animals and is described in another report. The overall incidence of testicular tumors is 8% in DES-exposed male mice. No comparable lesions were seen in 122 control male mice. These results suggest that the testicular lesions that can occur following prenatal DES exposure include neoplasia. The combined prevalence of DES-induced tumors of the corpus testis and rete testis in mice suggests the male offspring may be more at risk for developing carcinoma of the reproductive tract than the female offspring. JF - The Journal of urology AU - Newbold, R R AU - Bullock, B C AU - McLachlan, J A AD - Developmental Endocrinology and Pharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1446 EP - 1450 VL - 138 IS - 6 SN - 0022-5347, 0022-5347 KW - Diethylstilbestrol KW - 731DCA35BT KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Testis -- drug effects KW - Testis -- pathology KW - Mice KW - Time Factors KW - Male KW - Female KW - Pregnancy KW - Testicular Neoplasms -- pathology KW - Diethylstilbestrol -- toxicity KW - Leydig Cell Tumor -- pathology KW - Testicular Neoplasms -- chemically induced KW - Leydig Cell Tumor -- chemically induced KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77818321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Testicular+tumors+in+mice+exposed+in+utero+to+diethylstilbestrol.&rft.au=Newbold%2C+R+R%3BBullock%2C+B+C%3BMcLachlan%2C+J+A&rft.aulast=Newbold&rft.aufirst=R&rft.date=1987-12-01&rft.volume=138&rft.issue=6&rft.spage=1446&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-30 N1 - Date created - 1987-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Abnormal ultraviolet mutagenic spectrum in plasmid DNA replicated in cultured fibroblasts from a patient with the skin cancer-prone disease, xeroderma pigmentosum. AN - 77812541; 3680516 AB - A shuttle vector plasmid, pZ189, was utilized to assess the types of mutations that cells from a patient with xeroderma pigmentosum, complementation group D, introduce into ultraviolet (UV) damaged, replicating DNA. Patients with xeroderma pigmentosum have clinical and cellular UV hypersensitivity, increased frequency of sun-induced skin cancer, and deficient DNA repair. In comparison to UV-treated pZ189 replicated in DNA repair-proficient cells, there were fewer surviving plasmids, a higher frequency of plasmids with mutations, fewer plasmids with two or more mutations in the marker gene, and a new mutagenic hotspot. The major type of base substitution mutation was the G:C to A:T transition with both cell lines. These results, together with similar findings published earlier with cells from a xeroderma pigmentosum patient in complementation group A, suggest that isolated G:C to A:T somatic mutations may be particularly important in generation of human skin cancer by UV radiation. JF - The Journal of clinical investigation AU - Seetharam, S AU - Protić-Sabljić, M AU - Seidman, M M AU - Kraemer, K H AD - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 1613 EP - 1617 VL - 80 IS - 6 SN - 0021-9738, 0021-9738 KW - DNA KW - 9007-49-2 KW - Abridged Index Medicus KW - Index Medicus KW - DNA Damage KW - Humans KW - Radiation Genetics KW - Female KW - Cell Line KW - Ultraviolet Rays KW - Xeroderma Pigmentosum -- genetics KW - Plasmids -- radiation effects KW - DNA -- radiation effects KW - Mutation KW - DNA Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77812541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Abnormal+ultraviolet+mutagenic+spectrum+in+plasmid+DNA+replicated+in+cultured+fibroblasts+from+a+patient+with+the+skin+cancer-prone+disease%2C+xeroderma+pigmentosum.&rft.au=Seetharam%2C+S%3BProti%C4%87-Sablji%C4%87%2C+M%3BSeidman%2C+M+M%3BKraemer%2C+K+H&rft.aulast=Seetharam&rft.aufirst=S&rft.date=1987-12-01&rft.volume=80&rft.issue=6&rft.spage=1613&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-12 N1 - Date created - 1988-01-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Intern Med. 1974 Feb;80(2):221-48 [4811796] J Mol Biol. 1964 Aug;9:372-5 [14202273] Proc Natl Acad Sci U S A. 1979 Aug;76(8):3982-6 [291058] Cell. 1982 Jun;29(2):451-8 [7116446] Biochimie. 1982 Aug-Sep;64(8-9):829-38 [6215955] Proc Natl Acad Sci U S A. 1983 Jan;80(2):487-91 [6300848] Carcinogenesis. 1984 Apr;5(4):511-4 [6705149] J Cell Physiol Suppl. 1984;3:45-62 [6378938] Lancet. 1984 Nov 17;2(8412):1138-42 [6150191] Proc Natl Acad Sci U S A. 1985 Oct;82(19):6622-6 [2995975] Clin Dermatol. 1985 Jan-Mar;3(1):33-69 [3833325] Biochemistry. 1986 May 6;25(9):2656-64 [3521740] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8273-7 [3464953] Mol Cell Biol. 1986 Jan;6(1):277-85 [3537686] Mutat Res. 1986 Nov;166(3):287-94 [3023995] Mol Cell Biol. 1986 Oct;6(10):3349-56 [3540589] Arch Dermatol. 1987 Feb;123(2):241-50 [3545087] Proc Natl Acad Sci U S A. 1987 Jun;84(11):3782-6 [3473483] Proc Natl Acad Sci U S A. 1987 Jun;84(11):3787-91 [3108878] Proc Natl Acad Sci U S A. 1987 Jul;84(14):4944-8 [3474635] Mutat Res. 1979 Feb;59(2):273-83 [375075] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of NK and ADCC activity by antibodies against purified cytoplasmic granules from rat LGL tumors. AN - 77811097; 3316462 AB - Highly purified preparations of cytoplasmic granules from transplantable rat large granular lymphocyte (LGL) tumor lines (rat natural killer (RNK) tumors) were used to immunize rabbits. Antibodies from these animals gave two precipitin lines with granule extracts in Ouchterlony experiments. They reacted with at least four different bands on nitrocellulose blots of SDS gels of LGL granule proteins. By immunofluorescence, specifically adsorbed antigranule antibodies did not recognize LGL or T cell surface antigens but reacted with the cytoplasmic granules in permeabilized RNK tumor cells as well as with normal rat LGL. These same antisera showed little or no reactivity with a panel of other cells, including peripheral blood T cells, thymocytes, macrophages, and EL-4 tumor cells. F(ab')2 preparations of these antigranule antibodies completely blocked granule-mediated lysis of both SRBC and nucleated targets, while control F(ab')2 preparations from rabbits immunized with EL-4 granules or TNP-KLH showed no significant inhibition of this cytolytic activity at the same antibody concentration. Anti-granule F(ab')2 preparations specifically inhibited (greater than 75%) rat natural killer (NK) and antibody-dependent cellular cytotoxicity (ADCC) activities in a dose-dependent manner but did not effect cytotoxic T cell activity. Pretreatment of either effectors or targets by these antibodies had no effect. Anti-granule F(ab')2 preparations, at concentrations showing strong inhibition of lysis, did not inhibit the binding of LGL to YAC-1 or Ab-coated P815 targets. These results demonstrate that a granule component(s) is necessary for the lytic activity of LGL in both NK and ADCC and provide the first direct evidence that a secretory event involving these granules is part of the lytic process. JF - Journal of leukocyte biology AU - Reynolds, C W AU - Reichardt, D AU - Henkart, M AU - Millard, P AU - Henkart, P AD - Cellular and Molecular Immunology Section, National Cancer Institute, Frederick Cancer Research Facility, Maryland. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 642 EP - 652 VL - 42 IS - 6 SN - 0741-5400, 0741-5400 KW - Antibodies KW - 0 KW - Immunoglobulin Fab Fragments KW - Neoplasm Proteins KW - Index Medicus KW - Rats KW - Animals KW - Neoplasm Proteins -- isolation & purification KW - Neoplasm Proteins -- immunology KW - Immunoglobulin Fab Fragments -- immunology KW - Cytotoxicity Tests, Immunologic KW - T-Lymphocytes, Cytotoxic -- immunology KW - Rabbits KW - Fluorescent Antibody Technique KW - Antibodies -- immunology KW - Lymphocytes -- immunology KW - Antibody-Dependent Cell Cytotoxicity KW - Cytoplasmic Granules -- immunology KW - Lymphocytes -- ultrastructure KW - Neoplasms, Experimental -- pathology KW - Killer Cells, Natural -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77811097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=Inhibition+of+NK+and+ADCC+activity+by+antibodies+against+purified+cytoplasmic+granules+from+rat+LGL+tumors.&rft.au=Reynolds%2C+C+W%3BReichardt%2C+D%3BHenkart%2C+M%3BMillard%2C+P%3BHenkart%2C+P&rft.aulast=Reynolds&rft.aufirst=C&rft.date=1987-12-01&rft.volume=42&rft.issue=6&rft.spage=642&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-04 N1 - Date created - 1988-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A novel cytotoxic T lymphocyte activation assay. Optimized conditions for antigen receptor triggered granule enzyme secretion. AN - 77844441; 3500234 AB - A method is described for the quantitative studies of cytotoxic T lymphocyte (CTL) activation. This functional assay is based on the measurements of secreted granule-associated enzymatic activity (BLT esterase (BLT-E) ) after incubation of CTL with activating stimuli. Immobilized mAb against CTL's antigen receptor (anti-TcR mAb), concanavalin A or a combination of PMA and ionophore A23187, were able to trigger the secretion of enzyme in the absence of target cells. Soluble anti-TcR mAb alone did not activate CTL, but using their conjugate with immobilized rabbit anti-mouse Ig antibody (RAMIg) TcR-mediated secretion of BLT-E was detected. Use of non-ionic detergents Nonidet P-40 or Triton X-100 (0.0125-0.2%) did not affect measurements of BLT-E activity. The efficiency of CTL exocytosis triggering by anti-TcR mAb which were immobilized on the surface of different plasticware is compared and conditions for studies of small and large numbers of CTL are described. The intensity of CTL response varies markedly with changes in buffer system, culture medium, additions of proteins. The optimal conditions for TcR complex triggered activation of murine CTL are described. Intensity of secretion can be easily manipulated by changing the surface density of immobilized anti-TcR mAb, thereby providing the possibility to screen inhibiting or activating agents (drugs or mAb) at selected sub-optimal levels of CTL activation. The potential for the use of described assay in screening of hybridoma supernatants for the presence of activating or inhibitory mAb against CTL's surface proteins is discussed. Since BLT-E secretion reflects exocytosis of granules from CTL, the conditions described here could be used for the detection of secretion of other markers of granules in future modifications of granule exocytosis assay. JF - Journal of immunological methods AU - Takayama, H AU - Trenn, G AU - Sitkovsky, M V AD - Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. Y1 - 1987/11/23/ PY - 1987 DA - 1987 Nov 23 SP - 183 EP - 190 VL - 104 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Antibodies, Monoclonal KW - 0 KW - Detergents KW - Plastics KW - Receptors, Antigen, T-Cell KW - Concanavalin A KW - 11028-71-0 KW - Esterases KW - EC 3.1.- KW - Granzymes KW - EC 3.4.21.- KW - Serine Endopeptidases KW - Index Medicus KW - Lymphocyte Activation KW - Cytoplasmic Granules -- enzymology KW - Animals KW - Kinetics KW - Exocytosis KW - Mice KW - Concanavalin A -- pharmacology KW - Cell Line KW - Cytotoxicity Tests, Immunologic -- methods KW - Serine Endopeptidases -- genetics KW - T-Lymphocytes, Cytotoxic -- immunology KW - Receptors, Antigen, T-Cell -- immunology KW - Esterases -- secretion KW - T-Lymphocytes, Cytotoxic -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77844441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunological+methods&rft.atitle=A+novel+cytotoxic+T+lymphocyte+activation+assay.+Optimized+conditions+for+antigen+receptor+triggered+granule+enzyme+secretion.&rft.au=Takayama%2C+H%3BTrenn%2C+G%3BSitkovsky%2C+M+V&rft.aulast=Takayama&rft.aufirst=H&rft.date=1987-11-23&rft.volume=104&rft.issue=1-2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunological+methods&rft.issn=00221759&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-04 N1 - Date created - 1988-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mechanisms of ultraviolet-induced mutation. Mutational spectra in the Escherichia coli lacI gene for a wild-type and an excision-repair-deficient strain. AN - 77915662; 2828636 AB - We have analyzed the DNA sequence changes in a total of 409 ultraviolet light-induced mutations in the lacI gene of Escherichia coli: 227 in a Uvr+ and 182 in a UvrB- strain. Both differences and similarities were observed. In both strains the mutations were predominantly (60 to 75%) base substitutions, followed by smaller contributions of single-base frameshifts, deletions and frameshift hotspot mutations. The base substitutions proved largely similar in the two strains but differences were observed among the single-base frameshifts, the deletions and the hotspot mutations. Among the base substitutions, both transitions (72.5%) and transversions (27.5%) were observed. The largest single group was G.C----A.T (60% of all base substitutions). The sites where G.C----A.T changes occurred were strongly correlated (97.5%) with sequences of adjacent pyrimidines, indicating mutation targeted ultraviolet photoproducts. Comparable amounts of mutation occurred at cytosine/cytosine and (mixed) cytosine/thymine sites. From an analysis of the prevalence of mutation at either the 5' or 3' side of a dipyrimidine, we conclude that both cyclobutane dimers and (6-4) lesions may contribute to mutation. Despite the general similarity of the base-substitution spectra between the wild-type and excision-defective strains, a number of sites were uniquely mutable in the UvrB- strain. Analysis of their surrounding DNA sequences suggested that, in addition to damage directly at the site of mutation, the potential for nearby opposite-strand damage may be important in determining the mutability of a site. The ultraviolet light-induced frameshift mutations were largely single-base losses. Inspection of the DNA sequences at which the frameshifts occurred suggested that they resulted from targeted mutagenesis, probably at cyclobutane pyrimidine dimers. The prevalence of frameshift mutations at homodimers (TT or CC) suggests that their formation involves local misalignment (slippage) and that base-pairing properties are partially retained in cyclobutane dimers. While the frameshift mutations in the Uvr+ strain were distributed over many different sites, more than half in the UvrB- strain were concentrated at a single site. Ultraviolet light-induced deletions as well as frameshift hotspot mutations (+/- TGGC at positions 620 to 632) are considered to be examples of untargeted or semitargeted mutagenesis. Hotspot mutations in the Uvr+ strain showed an increased contribution by (-)TGGC relative to (+)TGGC, indicating that ultraviolet light may specifically promote the loss of the four bases.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Journal of molecular biology AU - Schaaper, R M AU - Dunn, R L AU - Glickman, B W AD - Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/11/20/ PY - 1987 DA - 1987 Nov 20 SP - 187 EP - 202 VL - 198 IS - 2 SN - 0022-2836, 0022-2836 KW - DNA Transposable Elements KW - 0 KW - DNA, Bacterial KW - Index Medicus KW - Base Sequence -- radiation effects KW - DNA Repair KW - DNA, Bacterial -- radiation effects KW - Ultraviolet Rays KW - Genes, Bacterial -- radiation effects KW - Escherichia coli -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77915662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Mechanisms+of+ultraviolet-induced+mutation.+Mutational+spectra+in+the+Escherichia+coli+lacI+gene+for+a+wild-type+and+an+excision-repair-deficient+strain.&rft.au=Schaaper%2C+R+M%3BDunn%2C+R+L%3BGlickman%2C+B+W&rft.aulast=Schaaper&rft.aufirst=R&rft.date=1987-11-20&rft.volume=198&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-02 N1 - Date created - 1988-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of treatment on fertility in long-term survivors of childhood or adolescent cancer. AN - 77837749; 3683460 AB - In a retrospective cohort study of survivors of cancer and of controls, we estimated the risk of infertility after treatment for cancer during childhood or adolescence. We interviewed 2283 long-term survivors of childhood or adolescent cancer diagnosed in the period from 1945 through 1975, who were identified at five cancer centers in the United States. Requirements for admission to the study were diagnosis before the age of 20, survival for at least five years, and attainment of the age of 21. In addition, 3270 controls selected from among the survivors' siblings were interviewed. Cox regression analysis showed that cancer survivors who married and were presumed to be at risk of pregnancy were less likely than their sibling controls to have ever begun a pregnancy (relative fertility, 0.85; 95 percent confidence interval, 0.78 to 0.92). Radiation therapy directed below the diaphragm depressed fertility in both sexes by about 25 percent. Chemotherapy with alkylating agents, with or without radiation to sites below the diaphragm, was associated with a fertility deficit of about 60 percent in the men. Among the women, there was no apparent effect of alkylating-agent therapy administered alone (relative fertility, 1.02) and only a moderate fertility deficit when alkylating-agent therapy was combined with radiation below the diaphragm (relative fertility, 0.81). Relative fertility in the survivors varied considerably according to sex, site of cancer, and type of treatment; these factors should be taken into consideration in counseling survivors about the long-term consequences of disease. JF - The New England journal of medicine AU - Byrne, J AU - Mulvihill, J J AU - Myers, M H AU - Connelly, R R AU - Naughton, M D AU - Krauss, M R AU - Steinhorn, S C AU - Hassinger, D D AU - Austin, D F AU - Bragg, K AD - Clinical Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/11/19/ PY - 1987 DA - 1987 Nov 19 SP - 1315 EP - 1321 VL - 317 IS - 21 SN - 0028-4793, 0028-4793 KW - Alkylating Agents KW - 0 KW - Antineoplastic Agents KW - Abridged Index Medicus KW - Index Medicus KW - Population KW - Fertility KW - Age Factors KW - Research Methodology KW - Population Dynamics KW - Physiology KW - Retrospective Studies KW - Child KW - Urogenital Effects KW - Treatment KW - Infertility--men KW - Infertility--women KW - Population Characteristics KW - Adult KW - Demographic Factors KW - Data Collection KW - Diseases KW - Data Analysis KW - Time Factors KW - Youth KW - Adolescents KW - Studies KW - Longterm Effects KW - Cancer KW - Neoplasms KW - Urogenital System KW - Reproduction KW - Biology KW - Regression Analysis KW - Infertility, Male -- etiology KW - Humans KW - Infertility, Female -- etiology KW - Combined Modality Therapy -- adverse effects KW - Adolescent KW - Male KW - Female KW - Pregnancy KW - Fertility -- radiation effects KW - Neoplasms -- therapy KW - Alkylating Agents -- adverse effects KW - Radiotherapy -- adverse effects KW - Fertility -- drug effects KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77837749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Effects+of+treatment+on+fertility+in+long-term+survivors+of+childhood+or+adolescent+cancer.&rft.au=Byrne%2C+J%3BMulvihill%2C+J+J%3BMyers%2C+M+H%3BConnelly%2C+R+R%3BNaughton%2C+M+D%3BKrauss%2C+M+R%3BSteinhorn%2C+S+C%3BHassinger%2C+D+D%3BAustin%2C+D+F%3BBragg%2C+K&rft.aulast=Byrne&rft.aufirst=J&rft.date=1987-11-19&rft.volume=317&rft.issue=21&rft.spage=1315&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-18 N1 - Date created - 1987-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Oxytocin and cholecystokinin induce grooming behavior in the ventral tegmentum of the rat. AN - 77852558; 3690307 AB - Oxytocin (OXY) and cholecystokinin (CCK) coexist in neurons of the supraoptic nucleus and the paraventricular nucleus of the hypothalamus of the rat (Cell Tissue Res., 221 (1981) 227-231). Behavioral analysis of one possible terminal field of the OXY-CCK coexistence, the caudal region of the mesencephalic ventral tegmentum, was undertaken to investigate the functional significance of this coexistence. Both OXY and CCK were found to induce grooming behaviors when microinjected into the ventral tegmental area (VTA) of awake rats. Combinations of one low and one higher dose of OXY and CCK yielded grooming scores which were not significantly different from grooming scores induced by each peptide alone. In this case of putative coexistence of two peptides without a 'classical' neurotransmitter, each peptide appears to have a behavioral function, and the interaction between the two peptides may be competitive. JF - Brain research AU - Kaltwasser, M T AU - Crawley, J N AD - Unit on Behavioral Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892. Y1 - 1987/11/17/ PY - 1987 DA - 1987 Nov 17 SP - 1 EP - 7 VL - 426 IS - 1 SN - 0006-8993, 0006-8993 KW - Oxytocin KW - 50-56-6 KW - Cholecystokinin KW - 9011-97-6 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Microinjections KW - Female KW - Oxytocin -- administration & dosage KW - Cholecystokinin -- administration & dosage KW - Tegmentum Mesencephali -- physiology KW - Grooming -- drug effects KW - Tegmentum Mesencephali -- drug effects KW - Oxytocin -- pharmacology KW - Cholecystokinin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77852558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Oxytocin+and+cholecystokinin+induce+grooming+behavior+in+the+ventral+tegmentum+of+the+rat.&rft.au=Kaltwasser%2C+M+T%3BCrawley%2C+J+N&rft.aulast=Kaltwasser&rft.aufirst=M&rft.date=1987-11-17&rft.volume=426&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-25 N1 - Date created - 1988-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunohistochemical determination of inducibility phenotype with a monoclonal antibody to a methylcholanthrene-inducible isozyme of cytochrome P-450. AN - 81067232; 3664509 AB - A monoclonal antibody (MAb) to a methylcholanthrene (MC)-induced cytochrome P-450, designated MAb 1-7-1, was used for immunohistochemical staining of formalin-fixed tissues from oil- and MC-treated C57BL/6, DBA/2, and [(C57BL/6 X DBA/2) F1 X DBA/2] F2 mice. An avidin-biotin-peroxidase complex immunohistochemical technique was used. For controls, the tissues were also exposed to MAbs 1-48-5 and HyHel-9 (to egg white lysozyme). In liver, MAb 1-7-1 specifically stained the cytoplasm of centrilobular hepatocytes of C57BL/6 mice treated with MC (80 mg/kg) 48 h before kill; staining was not observed with vehicle-treated C57BL/6 mice, with oil- or MC-treated DBA/2 mice, or with comparable antibody concentrations of control MAbs 1-48-5 or HyHel-9. In the F2 mice, about 50% were expected to be MC inducible (AhbAhd). Inducibility phenotype was determined by measuring the conversion of [14C]MC to oxidized and conjugated products by liver homogenates. In freshly fixed material from MC-treated mice, those livers shown by the determination of phenotype to be inducible also stained with MAb 1-7-1, whereas those not induced were immunohistochemically negative. Furthermore, there was a significant positive correlation between degree of staining and the level of MC-metabolizing activity measured biochemically. The immunohistochemical procedure was also accurate in determination of inducibility phenotype of livers that had been in paraffin blocks for up to 2 yr if more concentrated antibody was used. In lung, MAb 1-7-1 stained specifically the alveolar walls and endothelium of blood vessels in MC-induced C57BL/6 mice only; the control MAbs and other mice gave negative results. Similarly, in kidney MAb 1-7-1 stained only glomeruli and interstitial tissue of MC-induced C57BL/6 mice and only endothelium of blood vessels in the colons of these mice. These observations are consistent with induction of the cytochrome P-450 recognized by MAb 1-7-1 in the endothelial cells of extrahepatic tissue. Immunohistochemical staining with MAb thus shows great promise for highly specific localization of particular species of cytochromes P-450 in tissues, for in situ quantification of these enzymes, and for determination of inducibility phenotype with fixed material. JF - Cancer research AU - Anderson, L M AU - Ward, J M AU - Park, S S AU - Jones, A B AU - Junker, J L AU - Gelboin, H V AU - Rice, J M AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701-1013. Y1 - 1987/11/15/ PY - 1987 DA - 1987 Nov 15 SP - 6079 EP - 6085 VL - 47 IS - 22 SN - 0008-5472, 0008-5472 KW - Antibodies, Monoclonal KW - 0 KW - Isoenzymes KW - Methylcholanthrene KW - 56-49-5 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Mice KW - Mice, Inbred DBA KW - Phenotype KW - Biotransformation KW - Mice, Inbred C57BL KW - Crosses, Genetic KW - Enzyme Induction KW - Species Specificity KW - Immunohistochemistry KW - Female KW - Male KW - Intestinal Mucosa -- cytology KW - Liver -- cytology KW - Liver -- enzymology KW - Cytochrome P-450 Enzyme System -- genetics KW - Intestinal Mucosa -- enzymology KW - Lung -- cytology KW - Isoenzymes -- immunology KW - Kidney -- enzymology KW - Cytochrome P-450 Enzyme System -- biosynthesis KW - Methylcholanthrene -- metabolism KW - Isoenzymes -- genetics KW - Methylcholanthrene -- pharmacology KW - Isoenzymes -- biosynthesis KW - Cytochrome P-450 Enzyme System -- immunology KW - Kidney -- cytology KW - Lung -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81067232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Immunohistochemical+determination+of+inducibility+phenotype+with+a+monoclonal+antibody+to+a+methylcholanthrene-inducible+isozyme+of+cytochrome+P-450.&rft.au=Anderson%2C+L+M%3BWard%2C+J+M%3BPark%2C+S+S%3BJones%2C+A+B%3BJunker%2C+J+L%3BGelboin%2C+H+V%3BRice%2C+J+M&rft.aulast=Anderson&rft.aufirst=L&rft.date=1987-11-15&rft.volume=47&rft.issue=22&rft.spage=6079&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-17 N1 - Date created - 1987-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Molecular dosimetry of DNA adduct formation and cell toxicity in rat nasal mucosa following exposure to the tobacco specific nitrosamine 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and their relationship to induction of neoplasia. AN - 81066913; 3664508 AB - The molecular dosimetry of O6-methylguanine (O6MG) formation in DNA and cytotoxicity in respiratory and olfactory mucosa was determined during administration of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to male Fischer 344 rats. The dose response for O6MG formation differed considerably between respiratory and olfactory mucosa. The dose response was nonlinear in respiratory mucosa where the slope of the curve was very large for doses of NNK ranging from 0.3 to 3.0 mg/kg but much smaller in the dose range of 10 to 100 mg/kg. In contract, the dose response in the olfactory mucosa did not demonstrate such a large change in slope over the same dose range. The concentration of O6MG formed to dose of NNK ratio, an index of efficiency of alkylation, increased dramatically only in the respiratory mucosa as the dose of NNK was decreased from 100 to 0.3 mg/kg. The concentration of O6MG was four times greater in respiratory than olfactory mucosa after treatment of rats with 1 mg/kg NNK. Alkylation in the two regions of the nose became similar as the dose of NNK was increased. In rats treated for up to 12 days with NNK (10 mg/kg/day), the concentration of O6MG was 60 to 90% greater in respiratory than olfactory mucosa throughout treatment. Regional differences in the amount of O6MG formed may stem from the presence of a low Km pathway for biotransformation of NNK in the cells of the respiratory mucosa. This conclusion is supported by autoradiographic studies. Four h after treatment with 1 mg/kg [3H]NNK, silver grains were more heavily concentrated in respiratory than olfactory epithelium. Histopathological examination of the nasal passages revealed dose related, cell specific differences in toxicity following treatment of rats with 10, 30, or 100 mg/kg NNK for 12 days. No toxicity was observed in the nose when 1 mg/kg NNK was administered. Bowman's glands underlying the olfactory mucosa and Steno's glands were the most sensitive sites for toxicity, exhibiting necrosis after as little as 2 days of treatment with 10 mg/kg NNK. Damage to these glands progressed in a dose- and time-dependent manner. Respiratory epithelium exhibited only mild toxicity while basal cell metaplasia was evident in olfactory epithelium. Rats treated with NNK for 20 weeks (50 mg/kg, three times a week) had a 45% incidence of carcinomas in the olfactory region. These neoplasms appeared to arise from Bowman's glands. In contrast, there was only a 5% incidence of malignant neoplasia and a 29% incidence of benign neoplasia in the respiratory region.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Cancer research AU - Belinsky, S A AU - Walker, V E AU - Maronpot, R R AU - Swenberg, J A AU - Anderson, M W AD - Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/11/15/ PY - 1987 DA - 1987 Nov 15 SP - 6058 EP - 6065 VL - 47 IS - 22 SN - 0008-5472, 0008-5472 KW - Carcinogens KW - 0 KW - Nitrosamines KW - 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone KW - 7S395EDO61 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Necrosis KW - Methylation KW - Male KW - Plants, Toxic KW - Respiratory Tract Neoplasms -- chemically induced KW - Nitrosamines -- toxicity KW - Nasal Mucosa -- pathology KW - DNA -- metabolism KW - Nitrosamines -- metabolism KW - Tobacco KW - Nasal Mucosa -- drug effects KW - Respiratory Tract Neoplasms -- pathology KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81066913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Molecular+dosimetry+of+DNA+adduct+formation+and+cell+toxicity+in+rat+nasal+mucosa+following+exposure+to+the+tobacco+specific+nitrosamine+4-%28N-methyl-N-nitrosamino%29-1-%283-pyridyl%29-1-butanone+and+their+relationship+to+induction+of+neoplasia.&rft.au=Belinsky%2C+S+A%3BWalker%2C+V+E%3BMaronpot%2C+R+R%3BSwenberg%2C+J+A%3BAnderson%2C+M+W&rft.aulast=Belinsky&rft.aufirst=S&rft.date=1987-11-15&rft.volume=47&rft.issue=22&rft.spage=6058&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-17 N1 - Date created - 1987-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intrathecal administration of 4-hydroperoxycyclophosphamide in rhesus monkeys. AN - 81063064; 3664493 AB - The preactivated cyclophosphamide analogue, 4-HC, does not require activation by hepatic microsomal enzymes to express its cytotoxic activity and therefore, unlike cyclophosphamide, may be useful for the regional therapy of cancer. In the present study, the pharmacokinetics and toxicology of 4-HC were studied following intraventricular administration of 0.4 mg to rhesus monkeys with chronic indwelling Ommaya reservoirs. 4-HC was measured in cerebrospinal fluid (CSF) and plasma with a high-performance liquid chromatography assay utilizing a fluorometric detector following derivatization with m-aminophenol. The mean peak level of 4-HC in ventricular CSF was 100 microM 5 min after administration. The drug was cleared rapidly and the elimination was monoexponential with a mean half-life of 22 min. The mean clearance from CSF (0.33 ml/min) was 10-fold higher than CSF bulk flow. The drug was distributed throughout the subarachnoid space with lumbar levels approaching ventricular levels by 60 min. Neither acute nor chronic neurotoxicity or systemic toxicity was observed during the 6-wk observation period. Concentrations of 4-HC demonstrated to be cytocidal in vitro against human breast cancer, lymphoid leukemia, and rhabdomyosarcoma were readily achieved in CSF following intraventricular administration. This study demonstrates that intraventricular therapy with 4-HC is feasible and suggests that further study of this approach in the clinical setting should be considered. JF - Cancer research AU - Arndt, C A AU - Colvin, O M AU - Balis, F M AU - Lester, C M AU - Johnson, G AU - Poplack, D G AD - Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/11/15/ PY - 1987 DA - 1987 Nov 15 SP - 5932 EP - 5934 VL - 47 IS - 22 SN - 0008-5472, 0008-5472 KW - Antineoplastic Agents KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - perfosfamide KW - U880A4FUDA KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Animals KW - Cell Survival -- drug effects KW - Injections, Spinal KW - Macaca mulatta KW - Male KW - Cell Line KW - Cyclophosphamide -- administration & dosage KW - Cyclophosphamide -- analogs & derivatives KW - Antineoplastic Agents -- administration & dosage KW - Cyclophosphamide -- toxicity KW - Cyclophosphamide -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81063064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Intrathecal+administration+of+4-hydroperoxycyclophosphamide+in+rhesus+monkeys.&rft.au=Arndt%2C+C+A%3BColvin%2C+O+M%3BBalis%2C+F+M%3BLester%2C+C+M%3BJohnson%2C+G%3BPoplack%2C+D+G&rft.aulast=Arndt&rft.aufirst=C&rft.date=1987-11-15&rft.volume=47&rft.issue=22&rft.spage=5932&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-17 N1 - Date created - 1987-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells. AN - 81055615; 3478136 AB - Phorbol esters inhibit chemically induced differentiation in Friend erythroleukemia cells. This study examines the effect of the macrocyclic lactone bryostatin 1 on phorbol ester responses in a Friend erythroleukemia cell clone, PS 7. In several biological systems, bryostatin 1 was reported to mimic phorbol ester action, including activation of protein kinase C, but in HL-60 cells it blocked phorbol ester-induced differentiation. We report here that bryostatin 1 blocks phorbol ester action in Friend cells (clone PS 7), a second differentiating system. In this system, in contrast to HL-60 cells, the phorbol esters inhibit rather than induce differentiation. Bryostatin 1 restores the differentiation response [50% effective dose, 15 +/- 3.5 nM (SEM)] as well as blocks a second phorbol ester effect, induction of cellular adherence. The inhibition of erythroid differentiation by dexamethasone, a nonphorbol compound whose action presumably is not protein kinase C mediated, is unaffected by bryostatin 1. Although bryostatin 1 inhibits [3H]phorbol 12,13-dibutyrate binding in intact Friend erythroleukemia cell clone PS 7, the mechanism for the antagonism of phorbol ester action by bryostatin 1 in Friend cells cannot be explained by simple competition at the binding site. JF - Cancer research AU - Dell'Aquila, M L AU - Nguyen, H T AU - Herald, C L AU - Pettit, G R AU - Blumberg, P M AD - Molecular Mechanisms of Tumor Promotion Section, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/11/15/ PY - 1987 DA - 1987 Nov 15 SP - 6006 EP - 6009 VL - 47 IS - 22 SN - 0008-5472, 0008-5472 KW - Acetamides KW - 0 KW - Antineoplastic Agents KW - Bryostatins KW - Carcinogens KW - Lactones KW - Macrolides KW - Phorbol Esters KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - bryostatin 1 KW - 37O2X55Y9E KW - hexamethylene bisacetamide KW - LA133J59VU KW - Index Medicus KW - Animals KW - Kinetics KW - Humans KW - Leukemia, Erythroblastic, Acute -- pathology KW - Mice KW - Cell Differentiation -- drug effects KW - Cell Line KW - Phorbol Esters -- pharmacology KW - Carcinogens -- pharmacology KW - Acetamides -- pharmacology KW - Phorbol Esters -- antagonists & inhibitors KW - Antineoplastic Agents -- pharmacology KW - Leukemia, Experimental -- pathology KW - Lactones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81055615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Inhibition+by+bryostatin+1+of+the+phorbol+ester-induced+blockage+of+differentiation+in+hexamethylene+bisacetamide-treated+Friend+erythroleukemia+cells.&rft.au=Dell%27Aquila%2C+M+L%3BNguyen%2C+H+T%3BHerald%2C+C+L%3BPettit%2C+G+R%3BBlumberg%2C+P+M&rft.aulast=Dell%27Aquila&rft.aufirst=M&rft.date=1987-11-15&rft.volume=47&rft.issue=22&rft.spage=6006&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-17 N1 - Date created - 1987-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of human and rat hepatocyte metabolism and mutagenic activation of 2-acetylaminofluorene. AN - 81055500; 2822235 AB - A method has been developed to assess the metabolism and mutagenic activation of carcinogens using human and rodent hepatocytes in vitro. A slicing technique which was especially useful for nonperfusable biopsy and resected surgical human liver tissue was used to prepare the hepatocytes. Metabolites of the model carcinogen 2-acetylaminofluorene (AAF) produced by human and rat hepatocytes were similar and consisted primarily of 2-aminofluorene with ring hydroxylated products at the 1-, 3-, 5/9-, 7-, and 8-positions produced in addition to N-hydroxy-AAF. Sulphate and glucuronide conjugates of ring-hydroxylated metabolites and 2-aminofluorene were detected. Metabolism and cell-mediated Salmonella mutagenicity illustrated interindividual variation with human hepatocytes. Levels of metabolism and mutagenesis were generally higher with human hepatocytes compared to rat hepatocyte results. The increased levels of metabolism and mutagenesis of AAF by human hepatocytes compared to rat hepatocytes probably indicates a different sensitivity to hepatocarcinogenic effects of AAF on humans as compared to rats. Understanding differences and similarities between human and rodent carcinogen activation capabilities should be useful in the extrapolation of rodent carcinogenesis data to humans. JF - Cancer research AU - Rudo, K AU - Meyers, W C AU - Dauterman, W AU - Langenbach, R AD - Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/11/15/ PY - 1987 DA - 1987 Nov 15 SP - 5861 EP - 5867 VL - 47 IS - 22 SN - 0008-5472, 0008-5472 KW - Mutagens KW - 0 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Rats KW - Animals KW - Mutagenicity Tests KW - Biotransformation KW - Humans KW - In Vitro Techniques KW - Salmonella typhimurium -- drug effects KW - Biopsy KW - Species Specificity KW - Male KW - Female KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Liver -- pathology KW - Carcinoma, Hepatocellular -- metabolism KW - 2-Acetylaminofluorene -- pharmacology KW - 2-Acetylaminofluorene -- metabolism KW - Carcinoma, Hepatocellular -- pathology KW - Liver -- metabolism KW - Liver Neoplasms -- secondary KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81055500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Comparison+of+human+and+rat+hepatocyte+metabolism+and+mutagenic+activation+of+2-acetylaminofluorene.&rft.au=Rudo%2C+K%3BMeyers%2C+W+C%3BDauterman%2C+W%3BLangenbach%2C+R&rft.aulast=Rudo&rft.aufirst=K&rft.date=1987-11-15&rft.volume=47&rft.issue=22&rft.spage=5861&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-17 N1 - Date created - 1987-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The chemotherapy of lymphomas: looking back, moving forward--the Richard and Hinda Rosenthal Foundation award lecture. AN - 81055038; 3311358 JF - Cancer research AU - De Vita, V T AU - Hubbard, S M AU - Longo, D L AD - National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/11/15/ PY - 1987 DA - 1987 Nov 15 SP - 5810 EP - 5824 VL - 47 IS - 22 SN - 0008-5472, 0008-5472 KW - Procarbazine KW - 35S93Y190K KW - Mechlorethamine KW - 50D9XSG0VR KW - Vincristine KW - 5J49Q6B70F KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Animals KW - Procarbazine -- administration & dosage KW - Mechlorethamine -- administration & dosage KW - Humans KW - Vincristine -- administration & dosage KW - Prednisone -- administration & dosage KW - Hodgkin Disease -- drug therapy KW - Lymphoma -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81055038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=The+chemotherapy+of+lymphomas%3A+looking+back%2C+moving+forward--the+Richard+and+Hinda+Rosenthal+Foundation+award+lecture.&rft.au=De+Vita%2C+V+T%3BHubbard%2C+S+M%3BLongo%2C+D+L&rft.aulast=De+Vita&rft.aufirst=V&rft.date=1987-11-15&rft.volume=47&rft.issue=22&rft.spage=5810&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-17 N1 - Date created - 1987-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Control of animal pain and distress in cancer and toxicologic research. AN - 77867968; 3692969 JF - Journal of the American Veterinary Medical Association AU - Montgomery, C A AD - Toxicologic Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/11/15/ PY - 1987 DA - 1987 Nov 15 SP - 1277 EP - 1281 VL - 191 IS - 10 SN - 0003-1488, 0003-1488 KW - Index Medicus KW - Rats KW - Animals KW - Guinea Pigs KW - Mice KW - Research Design KW - Toxicology KW - Neoplasms, Experimental KW - Cricetinae KW - Pain -- prevention & control KW - Animal Welfare KW - Pain -- veterinary KW - Stress, Physiological -- prevention & control KW - Stress, Physiological -- veterinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77867968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Veterinary+Medical+Association&rft.atitle=Control+of+animal+pain+and+distress+in+cancer+and+toxicologic+research.&rft.au=Montgomery%2C+C+A&rft.aulast=Montgomery&rft.aufirst=C&rft.date=1987-11-15&rft.volume=191&rft.issue=10&rft.spage=1277&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Veterinary+Medical+Association&rft.issn=00031488&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-02 N1 - Date created - 1988-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of ouabain on NIH/3T3 cells transformed with retroviral oncogenes and on human tumor cell lines. AN - 77833691; 3679592 AB - Both murine and human cell lines transformed by the v-Ki-ras gene have been shown to be much more sensitive to the toxic effects of the cardiac glycoside ouabain than their respective controls. This differential toxicity has previously been used in the isolation of flat revertant clones from populations of Kirsten murine sarcoma virus transformed NIH/3T3 cells. Here, we have undertaken a further characterization of this phenomenon in murine and human tumor cells. Two different techniques, a 51Cr-release assay and a quantitative Crystal violet elution assay, have been employed to compare the sensitivities to ouabain of normal and v-Ki-ras-transformed NIH/3T3 cells. In each assay, ras-transformed NIH/3T3 cell lines displayed an increased sensitivity to ouabain as compared to the parental NIH/3T3 cell line, both in dose-response and in time-course experiments. In a separate study, ouabain was also able to inhibit the growth in semi-solid medium of 2 v-Ki-ras-transformed NIH/3T3 cell lines (DT and K-NIH) in a dose-dependent fashion. The same concentrations of ouabain were effective in both the 51Cr-release and Crystal violet assays. To address the question of whether increased sensitivity to ouabain is a specific result of transformation with the ras oncogene or is a common event which accompanies transformation by other oncogenes, we have screened a variety of transformed NIH/3T3 derivatives. All of these lines displayed an increased sensitivity to ouabain when compared to the parental NIH/3T3 cell line. JF - International journal of cancer AU - Tagliaferri, P AU - Yanagihara, K AU - Ciardiello, F AU - Talbot, N AU - Flatow, U AU - Benade, L AU - Bassin, R H AD - Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/11/15/ PY - 1987 DA - 1987 Nov 15 SP - 653 EP - 658 VL - 40 IS - 5 SN - 0020-7136, 0020-7136 KW - Chromium Radioisotopes KW - 0 KW - Ouabain KW - 5ACL011P69 KW - Gentian Violet KW - J4Z741D6O5 KW - Index Medicus KW - Animals KW - Cell Survival -- drug effects KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Cell Line -- drug effects KW - Cell Division -- drug effects KW - Drug Evaluation, Preclinical KW - Colonic Neoplasms KW - Tumor Virus Infections KW - Ouabain -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77833691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Effects+of+ouabain+on+NIH%2F3T3+cells+transformed+with+retroviral+oncogenes+and+on+human+tumor+cell+lines.&rft.au=Tagliaferri%2C+P%3BYanagihara%2C+K%3BCiardiello%2C+F%3BTalbot%2C+N%3BFlatow%2C+U%3BBenade%2C+L%3BBassin%2C+R+H&rft.aulast=Tagliaferri&rft.aufirst=P&rft.date=1987-11-15&rft.volume=40&rft.issue=5&rft.spage=653&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-21 N1 - Date created - 1987-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells. AN - 77808674; 2824607 AB - Antigen activation of murine T lymphocytes leads to phosphorylation of three subunits of the murine T cell antigen receptor (L.E. Samelson, M.D. Patel, A.M. Weissman, J.B. Harford, and R.D. Klausner. 1986. Cell 46:1083). Two kinases are activated in this process: protein kinase C which leads to phosphorylation of the gamma and, to a lesser extent, the epsilon subunits on serine residues and a tyrosine kinase which phosphorylates the p21 subunit (M.D. Patel, L.E. Samelson, and R.D. Klausner. 1987. J. Biol Chem. 262:5831). We sought to determine whether treatment of these cells with NaF could simulate any of these antigen-induced events. Indeed NaF treatment resulted in breakdown of polyphosphoinositides and production of phosphoinositols. This treatment also resulted in a rise in cytosolic free Ca2+. EGTA failed to block this rise suggesting that NaF liberated intracellular stores of Ca2+. Finally NaF treatment resulted in phosphorylation of the gamma and epsilon chains of the T cell receptor indistinguishable from the effects of phorbol esters. The NaF effect was potentiated by addition of A1Cl3 consistent with the view that the active moiety is A1F4-. The A1F4--induced phosphorylations were abolished in cells in which protein kinase C was depleted by prior treatment with phorbol myristate acetate. All of these observations are compatible with the interpretation that the A1F4- phosphorylation is mediated by protein kinase C. Antigen and anti-receptor antibody-induced receptor serine phosphorylation and phophatidylinositol turnover are blocked by raising intracellular levels of cyclic adenosine monophosphate. In contrast, A1F4--induced effects were insensitive to cyclic adenosine monophosphate. JF - Journal of immunology (Baltimore, Md. : 1950) AU - O'Shea, J J AU - Urdahl, K B AU - Luong, H T AU - Chused, T M AU - Samelson, L E AU - Klausner, R D AD - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892. Y1 - 1987/11/15/ PY - 1987 DA - 1987 Nov 15 SP - 3463 EP - 3469 VL - 139 IS - 10 SN - 0022-1767, 0022-1767 KW - Aluminum Compounds KW - 0 KW - Antigens KW - Membrane Lipids KW - Phosphatidylinositol Phosphates KW - Phosphatidylinositols KW - Receptors, Antigen, T-Cell KW - Colforsin KW - 1F7A44V6OU KW - Egtazic Acid KW - 526U7A2651 KW - Sodium Fluoride KW - 8ZYQ1474W7 KW - Aluminum KW - CPD4NFA903 KW - Cyclic AMP KW - E0399OZS9N KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Fluorides KW - Q80VPU408O KW - Calcium KW - SY7Q814VUP KW - aluminum fluoride KW - Z77H3IKW94 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cytosol -- metabolism KW - Mice KW - Protein-Tyrosine Kinases -- metabolism KW - Protein Kinase C -- metabolism KW - Colforsin -- pharmacology KW - Phosphorylation KW - Cyclic AMP -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Sodium Fluoride -- pharmacology KW - Antigens -- immunology KW - Egtazic Acid -- pharmacology KW - Calcium -- metabolism KW - Phosphatidylinositols -- metabolism KW - T-Lymphocytes -- metabolism KW - Aluminum -- pharmacology KW - Receptors, Antigen, T-Cell -- metabolism KW - Membrane Lipids -- metabolism KW - Fluorides -- pharmacology KW - T-Lymphocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77808674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Aluminum+fluoride+induces+phosphatidylinositol+turnover%2C+elevation+of+cytoplasmic+free+calcium%2C+and+phosphorylation+of+the+T+cell+antigen+receptor+in+murine+T+cells.&rft.au=O%27Shea%2C+J+J%3BUrdahl%2C+K+B%3BLuong%2C+H+T%3BChused%2C+T+M%3BSamelson%2C+L+E%3BKlausner%2C+R+D&rft.aulast=O%27Shea&rft.aufirst=J&rft.date=1987-11-15&rft.volume=139&rft.issue=10&rft.spage=3463&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-22 N1 - Date created - 1987-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - MPDP+ causes a non-reversible decrease in neostriatal synaptic transmission in mouse brain slice. AN - 77895172; 2827846 AB - MPTP causes a Parkinson's disease-like syndrome in man and certain other animals. The toxic effect occurs if monoamine oxidase B is available, indicating that an MPTP metabolite may cause the toxic effect. We tested the effect of MPDP+, the first product of MPTP oxidation, and found that it, like MPTP, caused a non-reversible decrease in synaptic transmission in the mouse brain slice preparation. As the second oxidation product, MPP+ had been shown not to cause a similar, non-reversible decrease in synaptic transmission, MPDP+ is a better candidate for the role of toxic substance. JF - Brain research AU - Wilson, J A AU - Wilson, J S AU - Weight, F F AD - Laboratory of Preclinical Studies, National Institute on Alcohol, Abuse and Alcoholism, Rockville, MD 20852. Y1 - 1987/11/10/ PY - 1987 DA - 1987 Nov 10 SP - 376 EP - 379 VL - 425 IS - 2 SN - 0006-8993, 0006-8993 KW - Pyridinium Compounds KW - 0 KW - 1-methyl-4-phenyl-2,3-dihydropyridinium KW - 94613-45-3 KW - Pargyline KW - 9MV14S8G3E KW - Index Medicus KW - Animals KW - Pargyline -- pharmacology KW - In Vitro Techniques KW - Mice KW - Synapses -- physiology KW - Corpus Striatum -- physiology KW - Synapses -- drug effects KW - Synaptic Transmission -- drug effects KW - Corpus Striatum -- ultrastructure KW - Pyridinium Compounds -- pharmacology KW - Corpus Striatum -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77895172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=MPDP%2B+causes+a+non-reversible+decrease+in+neostriatal+synaptic+transmission+in+mouse+brain+slice.&rft.au=Wilson%2C+J+A%3BWilson%2C+J+S%3BWeight%2C+F+F&rft.aulast=Wilson&rft.aufirst=J&rft.date=1987-11-10&rft.volume=425&rft.issue=2&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-04 N1 - Date created - 1988-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolism of excess methionine in the liver of intact rat: an in vivo 2H NMR study. AN - 77911234; 2447942 AB - L-Methionine is the most toxic amino acid if supplied in excess, and the metabolic basis for this toxicity has been extensively studied, with varying conclusions. It is demonstrated here that in vivo 2H NMR spectroscopy provides a useful approach to the study of the hepatic metabolism of methionine in the anesthetized rat. Resonances corresponding to administered L-[methyl-2H3]methionine, and to the transmethylation product sarcosine, are observed during the first 10-min period after an intravenous injection of the labeled methionine, and the time dependence has been followed for a period of 5 h. A third resonance, assigned to the N-trimethyl groups of carnitine, phosphorylcholine, and other metabolites, becomes observable several hours after administration of the deuteriated methionine. In addition, there is a small increase in the intensity of the HDO resonance over the period of the study, which is interpreted to reflect the ultimate oxidation of the labeled sarcosine methyl group via mitochondrial sarcosine dehydrogenase. Additional small 2H resonances assigned to N1-methylhistidine and creatine could be observed in perchloric acid extracts of the livers of rats treated with the deuteriated methionine. Inhibition of the flux through the transmethylation pathway is observed in the rat pretreated with the S-ethyl analogue of methionine, ethionine. These data provide strong support for the importance of glycine transmethylation in the catabolism of excess methionine. JF - Biochemistry AU - London, R E AU - Gabel, S A AU - Funk, A AD - Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/11/03/ PY - 1987 DA - 1987 Nov 03 SP - 7166 EP - 7172 VL - 26 IS - 22 SN - 0006-2960, 0006-2960 KW - Methionine KW - AE28F7PNPL KW - Deuterium KW - AR09D82C7G KW - Sarcosine KW - Z711V88R5F KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Magnetic Resonance Spectroscopy -- methods KW - Methylation KW - Male KW - Sarcosine -- metabolism KW - Methionine -- metabolism KW - Liver -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77911234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Metabolism+of+excess+methionine+in+the+liver+of+intact+rat%3A+an+in+vivo+2H+NMR+study.&rft.au=London%2C+R+E%3BGabel%2C+S+A%3BFunk%2C+A&rft.aulast=London&rft.aufirst=R&rft.date=1987-11-03&rft.volume=26&rft.issue=22&rft.spage=7166&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-18 N1 - Date created - 1988-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test. AN - 85257280; pmid-3675128 AB - Recent physiological and cognitive studies of schizophrenia have implicated dysfunction of prefrontal cortex as a possible explanation for some of the disabling intellectual and social aspects of the disorder. To investigate the potential reversibility of cognitive deficits and the role of state variables, eg, attention and motivation, three groups of patients with schizophrenia were administered the Wisconsin Card Sorting Test on six consecutive occasions. Two of the groups received incremental information on how to do the test, including explicit card-by-card instruction. The third group served as a control. Regardless of the degree of instruction, patients who could not do the test could not learn it. The deficit did not appear generalized, as patients were able to learn word lists on the Selective Reminding memory test and were not globally demented on the Mini-Mental State Examination. These data suggest that prefrontal-type cognitive deficits in schizophrenia may be more profound than is generally appreciated. JF - Archives of General Psychiatry AU - Goldberg, T E AU - Weinberger, D R AU - Berman, K F AU - Pliskin, N H AU - Podd, M H AD - Clinical Brain Disorders Branch, National Institute of Mental Health, St. Elizabeths Hospital, Washington, DC 20032. PY - 1987 SP - 1008 EP - 1014 VL - 44 IS - 11 SN - 0003-990X, 0003-990X KW - Frontal Lobe KW - Schizophrenia KW - Psychiatric Status Rating Scales KW - Human KW - Adult KW - Schizophrenic Psychology KW - Dementia KW - Female KW - Male KW - Psychological Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85257280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+General+Psychiatry&rft.atitle=Further+evidence+for+dementia+of+the+prefrontal+type+in+schizophrenia%3F+A+controlled+study+of+teaching+the+Wisconsin+Card+Sorting+Test.&rft.au=Goldberg%2C+T+E%3BWeinberger%2C+D+R%3BBerman%2C+K+F%3BPliskin%2C+N+H%3BPodd%2C+M+H&rft.aulast=Goldberg&rft.aufirst=T&rft.date=1987-11-01&rft.volume=44&rft.issue=11&rft.spage=1008&rft.isbn=&rft.btitle=&rft.title=Archives+of+General+Psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Speech timing in Parkinson's and Huntington's disease. AN - 85167521; pmid-2961409 AB - The purpose was to determine the effects of two different basal ganglia diseases on speech planning, initiation, and production. Patients with Parkinson's Disease (PD) and Huntington's Disease (HD) were compared with normal subjects on speech timing tasks. Speech reaction time was unimpaired, while changes in duration at different speech rates were affected differently in the two patient groups. In HD, changes in the duration of syllables, of pauses between phrases, and of sentences were all reduced, while in PD only the control of sentence duration was impaired. The HD patients had reduced syllable repetition rates, but both patient groups maintained their repetition rates over 5 sec. The ratios of word to phrase time, and of phrase to sentence time, remained constant across regular and fast speaking rates and did not differ from normal in either patient group. The results suggest that PD and HD patients are not impaired in speech planning or initiation, but have poor control over the duration of speech events. JF - Brain and Language AU - Ludlow, Christy L AU - Connor, N P AU - Bassich, Celia J AD - Laryngeal and Speech Section, National Institute of Neurological Disorders and Stroke; Department of Audiology, Speech-Language Pathology and Deaf Studies, College of Health Professions, Towson University PY - 1987 SP - 195 EP - 214 VL - 32 IS - 2 SN - 0093-934X, 0093-934X UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85167521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Speech+timing+in+Parkinson%27s+and+Huntington%27s+disease.&rft.au=Ludlow%2C+Christy+L%3BConnor%2C+N+P%3BBassich%2C+Celia+J&rft.aulast=Ludlow&rft.aufirst=Christy&rft.date=1987-11-01&rft.volume=32&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The effects of antidepressants on the cerebrospinal fluid homovanillic acid/5-hydroxyindoleacetic acid ratio. AN - 81109794; 2445515 AB - Dopamine and serotonin systems are morphologically interconnected in the midbrain. Several studies have also demonstrated a functional relationship between these two monoamine systems. Concentrations of their metabolites, 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA), consistently correlate with one another in human cerebrospinal fluid. Previous studies of the effects of antidepressants on the dopamine and serotonin systems have focused on the two systems in isolation without considering the interactions between the two. One way of taking this interaction into account may be to form a ratio of dopamine and serotonin measures. The present study measured HVA and 5HIAA in cerebrospinal fluid of 31 patients with depression and 12 patients with Alzheimer's disease before and after treatment with a variety of antidepressant drugs. The ratio of HVA/5HIAA was able to discriminate much more powerfully between effects of different drugs than HVA or 5HIAA examined separately. JF - Clinical pharmacology and therapeutics AU - Risby, E D AU - Hsiao, J K AU - Sunderland, T AU - Agren, H AU - Rudorfer, M V AU - Potter, W Z AD - Section on Clinical Pharmacology, National Institute of Mental Health, Bethesda, MD 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 547 EP - 554 VL - 42 IS - 5 SN - 0009-9236, 0009-9236 KW - Antidepressive Agents KW - 0 KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Homovanillic Acid KW - X77S6GMS36 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Evaluation KW - Drug Interactions KW - Spinal Puncture -- methods KW - Humans KW - Alzheimer Disease -- drug therapy KW - Depressive Disorder -- drug therapy KW - Alzheimer Disease -- cerebrospinal fluid KW - Depressive Disorder -- cerebrospinal fluid KW - Homovanillic Acid -- cerebrospinal fluid KW - Hydroxyindoleacetic Acid -- cerebrospinal fluid KW - Antidepressive Agents -- therapeutic use KW - Cerebrospinal Fluid -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81109794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=The+effects+of+antidepressants+on+the+cerebrospinal+fluid+homovanillic+acid%2F5-hydroxyindoleacetic+acid+ratio.&rft.au=Risby%2C+E+D%3BHsiao%2C+J+K%3BSunderland%2C+T%3BAgren%2C+H%3BRudorfer%2C+M+V%3BPotter%2C+W+Z&rft.aulast=Risby&rft.aufirst=E&rft.date=1987-11-01&rft.volume=42&rft.issue=5&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=00099236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-29 N1 - Date created - 1987-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Can antidepressants cause mania and worsen the course of affective illness? AN - 81104373; 3314536 AB - Several investigators have recently challenged the belief that antidepressants can precipitate mania or rapid cycling between mania and depression. With one exception, there appear to be no placebo-controlled studies of switches into mania in bipolar patients during antidepressant treatment. Patients most likely to switch into mania during antidepressant therapy have probably been excluded from maintenance treatment studies and are probably overrepresented in studies at special research facilities. On balance, the available evidence suggests that some bipolar patients become manic, and a few experience rapid cycling, when they are treated with antidepressants. The prevention of these responses will require further research on risk factors and on the antimanic efficacy of coadministered lithium or other mood stabilizers. JF - The American journal of psychiatry AU - Wehr, T A AU - Goodwin, F K AD - Intramural Research Program, NIMH, Bethesda, MD 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 1403 EP - 1411 VL - 144 IS - 11 SN - 0002-953X, 0002-953X KW - Antidepressive Agents KW - 0 KW - Antidepressive Agents, Tricyclic KW - Abridged Index Medicus KW - Index Medicus KW - Depressive Disorder -- prevention & control KW - Double-Blind Method KW - Humans KW - Clinical Trials as Topic KW - Depressive Disorder -- drug therapy KW - Antidepressive Agents, Tricyclic -- adverse effects KW - Bipolar Disorder -- drug therapy KW - Bipolar Disorder -- prevention & control KW - Antidepressive Agents -- adverse effects KW - Bipolar Disorder -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81104373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Can+antidepressants+cause+mania+and+worsen+the+course+of+affective+illness%3F&rft.au=Wehr%2C+T+A%3BGoodwin%2C+F+K&rft.aulast=Wehr&rft.aufirst=T&rft.date=1987-11-01&rft.volume=144&rft.issue=11&rft.spage=1403&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-03 N1 - Date created - 1987-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of sugar and aspartame on aggression and activity in children. AN - 81101841; 3674234 AB - Habitual sugar consumption and behavior following challenge by sugar and aspartame were studied in 30 preschool boys. The 18 subjects whose parents considered them sugar reactive had more disruptive behavior problems at baseline than the other 12 subjects. Habitual sugar consumption correlated only with duration of aggression against property in alleged responders. Double-blind crossover challenges with aspartame, saccharin, sucrose, and glucose produced no significant effect on aggression or observers' ratings of behavior. Lower actometer counts followed the trials of aspartame, but the difference was not apparent to observers. It is unlikely that sugar and aspartame are clinically significant causes of disruptive behavior. JF - The American journal of psychiatry AU - Kruesi, M J AU - Rapoport, J L AU - Cummings, E M AU - Berg, C J AU - Ismond, D R AU - Flament, M AU - Yarrow, M AU - Zahn-Waxler, C AD - Child Psychiatry Branch, NIMH, Bethesda, MD 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 1487 EP - 1490 VL - 144 IS - 11 SN - 0002-953X, 0002-953X KW - Dietary Carbohydrates KW - 0 KW - Dipeptides KW - Sucrose KW - 57-50-1 KW - Saccharin KW - FST467XS7D KW - Glucose KW - IY9XDZ35W2 KW - Aspartame KW - Z0H242BBR1 KW - Abridged Index Medicus KW - Index Medicus KW - Sucrose -- adverse effects KW - Glucose -- pharmacology KW - Saccharin -- pharmacology KW - Humans KW - Glucose -- adverse effects KW - Motor Activity -- drug effects KW - Sucrose -- pharmacology KW - Saccharin -- adverse effects KW - Male KW - Child, Preschool KW - Aspartame -- pharmacology KW - Aggression -- drug effects KW - Dietary Carbohydrates -- pharmacology KW - Dietary Carbohydrates -- adverse effects KW - Child Behavior Disorders -- chemically induced KW - Child Behavior -- drug effects KW - Aspartame -- adverse effects KW - Dipeptides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81101841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Effects+of+sugar+and+aspartame+on+aggression+and+activity+in+children.&rft.au=Kruesi%2C+M+J%3BRapoport%2C+J+L%3BCummings%2C+E+M%3BBerg%2C+C+J%3BIsmond%2C+D+R%3BFlament%2C+M%3BYarrow%2C+M%3BZahn-Waxler%2C+C&rft.aulast=Kruesi&rft.aufirst=M&rft.date=1987-11-01&rft.volume=144&rft.issue=11&rft.spage=1487&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-03 N1 - Date created - 1987-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Controllable and uncontrollable stress in humans: alterations in mood and neuroendocrine and psychophysiological function. AN - 81101475; 2823617 AB - The authors exposed 10 healthy human volunteers to the stress of loud (100 dB) noise under controllable and uncontrollable conditions on two separate days. Subjects reported higher self-ratings of helplessness, lack of control, tension, stress, unhappiness, anxiety, and depression; had greater hypothalamic-pituitary-adrenal axis function as measured by elevations in plasma adrenocorticotropic hormone; and had higher levels of sympathetic nervous system and electrodermal activity after the uncontrollable stress condition than after exposure to controllable stress. Thus, lack of control over even a mildly aversive stimulus can produce alterations in mood as well as neuroendocrine and autonomic nervous system changes in healthy subjects. JF - The American journal of psychiatry AU - Breier, A AU - Albus, M AU - Pickar, D AU - Zahn, T P AU - Wolkowitz, O M AU - Paul, S M AD - Section on Clinical Studies, NIMH, Bethesda, Md. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 1419 EP - 1425 VL - 144 IS - 11 SN - 0002-953X, 0002-953X KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Norepinephrine KW - X4W3ENH1CV KW - Epinephrine KW - YKH834O4BH KW - Abridged Index Medicus KW - Index Medicus KW - Anxiety -- psychology KW - Norepinephrine -- blood KW - Humans KW - Arousal -- physiology KW - Personality Inventory KW - Epinephrine -- blood KW - Depression -- etiology KW - Depression -- psychology KW - Adult KW - Noise KW - Acoustic Stimulation KW - Anxiety -- etiology KW - Female KW - Male KW - Helplessness, Learned KW - Galvanic Skin Response KW - Affect -- physiology KW - Life Change Events KW - Stress, Psychological -- physiopathology KW - Adrenocorticotropic Hormone -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81101475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Controllable+and+uncontrollable+stress+in+humans%3A+alterations+in+mood+and+neuroendocrine+and+psychophysiological+function.&rft.au=Breier%2C+A%3BAlbus%2C+M%3BPickar%2C+D%3BZahn%2C+T+P%3BWolkowitz%2C+O+M%3BPaul%2C+S+M&rft.aulast=Breier&rft.aufirst=A&rft.date=1987-11-01&rft.volume=144&rft.issue=11&rft.spage=1419&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-03 N1 - Date created - 1987-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The infected chest wall prosthesis: management by excision and contralateral transverse rectus abdominis musculocutaneous flap. AN - 81100608; 2823732 AB - A patient with a chest wall sarcoma whose original prosthetic reconstruction became infected after a course of radiation therapy is described. After removal of the prosthesis, salvage reconstruction was performed using a transverse rectus abdominis musculocutaneous flap. Management of the infected chest wall prosthesis, with emphasis on the indications for use of the transverse rectus abdominis musculocutaneous flap, is discussed. JF - The Annals of thoracic surgery AU - Wiebke, E A AU - McDonald, H D AU - Pass, H I AD - Thoracic Oncology Section, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 544 EP - 545 VL - 44 IS - 5 SN - 0003-4975, 0003-4975 KW - Methylmethacrylates KW - 0 KW - Plastipore KW - Polyethylenes KW - Polypropylenes KW - Methylmethacrylate KW - 196OC77688 KW - Abridged Index Medicus KW - Index Medicus KW - Thoracic Neoplasms -- therapy KW - Combined Modality Therapy KW - Humans KW - Histiocytoma, Benign Fibrous -- therapy KW - Middle Aged KW - Male KW - Radiotherapy -- adverse effects KW - Surgical Wound Infection -- surgery KW - Thoracic Diseases -- surgery KW - Surgical Flaps KW - Prostheses and Implants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81100608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+thoracic+surgery&rft.atitle=The+infected+chest+wall+prosthesis%3A+management+by+excision+and+contralateral+transverse+rectus+abdominis+musculocutaneous+flap.&rft.au=Wiebke%2C+E+A%3BMcDonald%2C+H+D%3BPass%2C+H+I&rft.aulast=Wiebke&rft.aufirst=E&rft.date=1987-11-01&rft.volume=44&rft.issue=5&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+thoracic+surgery&rft.issn=00034975&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-14 N1 - Date created - 1987-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Teratogenic effects of polychlorinated dibenzofurans in combination in C57BL/6N mice. AN - 81092587; 3672524 AB - Polychlorinated dibenzofurans (PCDFs) are highly toxic environmental contaminants which have been involved in several incidents of human poisoning. Two congeners, 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF) and 1,2,3,4,7,8-hexachlorodibenzofuran (HCDF), have been shown to persist in the tissues of victims of accidental ingestion from Japan and Taiwan. The teratogenicity of these compounds, both alone and in combination, was assessed in C57BL/6N mice. Pregnant mice were treated with 10 ml/kg corn oil containing no PCDFs, 4-PeCDF (0-30 micrograms/kg), HCDF (0-300 micrograms/kg), or a combination of the two on gestation Days 10-13, followed by necropsy on gestation Day 18. Maternal and fetal toxicity were assessed and selected soft tissues were examined for abnormalities. Both chemicals caused hydronephrosis and cleft palate in the absence of any overt toxicity. Hydronephrosis occurred at doses approximately fivefold lower than those causing cleft palate. The combination of 4-PeCDF and HCDF was additive for terata based on responses predicted by probit analysis. In addition, the combination of 2,3,4,5,3',4'-hexachlorobiphenyl (0-60 mg/kg), a structurally related compound also present in PCDF poisoning victims, and 4-PeCDF appears additive. Thus, these chemicals, which cause toxic effects similar to those of 2,3,7,8-tetrachlorodibenzo-p-dioxin, are additive in the induction of fetal anomalies in the mouse. JF - Toxicology and applied pharmacology AU - Birnbaum, L S AU - Harris, M W AU - Crawford, D D AU - Morrissey, R E AD - Systemic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 246 EP - 255 VL - 91 IS - 2 SN - 0041-008X, 0041-008X KW - Benzofurans KW - 0 KW - Polymers KW - Teratogens KW - polychlorodibenzofuran KW - Index Medicus KW - Cleft Palate -- chemically induced KW - Animals KW - Fetus -- drug effects KW - Body Weight -- drug effects KW - Mice, Inbred C57BL KW - Mice KW - Female KW - Structure-Activity Relationship KW - Pregnancy KW - Hydronephrosis -- chemically induced KW - Fetal Death KW - Benzofurans -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81092587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Teratogenic+effects+of+polychlorinated+dibenzofurans+in+combination+in+C57BL%2F6N+mice.&rft.au=Birnbaum%2C+L+S%3BHarris%2C+M+W%3BCrawford%2C+D+D%3BMorrissey%2C+R+E&rft.aulast=Birnbaum&rft.aufirst=L&rft.date=1987-11-01&rft.volume=91&rft.issue=2&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-11 N1 - Date created - 1987-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas. AN - 81090773; 2890168 AB - We have previously reported the isolation of a human breast cancer cell line resistant to doxorubicin (adriamycin; AdrR MCF-7 cells) that has also developed the phenotype of multidrug resistance (MDR). MDR in this cell line is associated with increased expression of mdr (P glycoprotein) gene sequences. The development of MDR in AdrR MCF-7 cells is also associated with changes in the expression of several phase I and phase II drug-detoxifying enzymes. These changes are remarkably similar to those associated with development of xenobiotic resistance in rat hyperplastic liver nodules, a well-studied model system of chemical carcinogenesis. Using an mdr-encoded cDNA sequence isolated from AdrR MCF-7 cells, we have examined the expression of mdr sequences in rat livers under a variety of experimental conditions. The expression of mdr increased 3-fold in regenerating liver. It was also elevated (3- to 12-fold) in several different samples of rat hyperplastic nodules and in four of five hepatomas that developed in this system. This suggests that overexpression of mdr, a gene previously associated with resistance to antineoplastic agents, may also be involved in the development of resistance to xenobiotics in rat hyperplastic nodules. In addition, although the acute administration of 2-acetylaminofluorene induced an 8-fold increase in hepatic mdr-encoded RNA, performance of a partial hepatectomy either before or after administration of 2-acetylaminofluorene resulted in a greater than 80-fold increase in mdr gene expression over that in normal untreated livers. This represents an important in vivo model system in which to study the acute regulation of this drug resistance gene. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Fairchild, C R AU - Ivy, S P AU - Rushmore, T AU - Lee, G AU - Koo, P AU - Goldsmith, M E AU - Myers, C E AU - Farber, E AU - Cowan, K H AD - Clinical Pharmacology Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 7701 EP - 7705 VL - 84 IS - 21 SN - 0027-8424, 0027-8424 KW - Membrane Glycoproteins KW - 0 KW - P-Glycoprotein KW - Doxorubicin KW - 80168379AG KW - DNA KW - 9007-49-2 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Rats KW - DNA -- isolation & purification KW - Animals KW - Doxorubicin -- pharmacology KW - Humans KW - Drug Resistance KW - Breast Neoplasms KW - Liver Regeneration KW - Female KW - Cell Line KW - Membrane Glycoproteins -- genetics KW - 2-Acetylaminofluorene -- toxicity KW - Transcription, Genetic -- drug effects KW - Liver Neoplasms, Experimental -- pathology KW - Oncogenes -- drug effects KW - Precancerous Conditions -- chemically induced KW - Precancerous Conditions -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81090773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Carcinogen-induced+mdr+overexpression+is+associated+with+xenobiotic+resistance+in+rat+preneoplastic+liver+nodules+and+hepatocellular+carcinomas.&rft.au=Fairchild%2C+C+R%3BIvy%2C+S+P%3BRushmore%2C+T%3BLee%2C+G%3BKoo%2C+P%3BGoldsmith%2C+M+E%3BMyers%2C+C+E%3BFarber%2C+E%3BCowan%2C+K+H&rft.aulast=Fairchild&rft.aufirst=C&rft.date=1987-11-01&rft.volume=84&rft.issue=21&rft.spage=7701&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-09 N1 - Date created - 1987-12-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1986 Jun;83(11):3847-50 [3459160] J Biol Chem. 1986 Jun 15;261(17):7921-8 [3711117] Cell. 1986 Nov 7;47(3):371-80 [3768958] Cell. 1986 Nov 7;47(3):381-9 [2876781] Mol Cell Biol. 1986 Mar;6(3):878-86 [3022136] J Biol Chem. 1986 Nov 25;261(33):15544-9 [3782078] Mol Cell Biol. 1986 May;6(5):1671-8 [2431283] Nature. 1986 Dec 4-10;324(6096):485-9 [2878368] Lab Invest. 1987 Jan;56(1):4-22 [3025514] Proc Natl Acad Sci U S A. 1986 Dec;83(24):9328-32 [3540935] Proc Natl Acad Sci U S A. 1987 Jan;84(1):265-9 [2432605] Science. 1987 May 29;236(4805):1120-2 [3576227] Cancer Res. 1970 Apr;30(4):1174-84 [5533992] J Cell Physiol. 1974 Feb;83(1):103-16 [4855907] Cancer Res. 1976 Nov;36(11 Pt 1):3879-87 [975037] Cancer Res. 1976 Nov;36(11 Pt 1):3888-93 [184917] Biochim Biophys Acta. 1976 Nov 11;455(1):152-62 [990323] Nature. 1977 Jan 27;265(5592):343-5 [834282] Cancer Res. 1979 Jun;39(6 Pt 1):2070-6 [571759] Br J Cancer. 1979 Nov;40(5):782-90 [41564] Cancer Res. 1980 Apr;40(4):1157-64 [6101993] Virology. 1982 May;119(1):22-34 [6280384] Cancer Res. 1982 Sep;42(9):3747-52 [6179609] Cancer Res. 1983 Jan;43(1):188-91 [6291753] Cancer Res. 1983 Jan;43(1):222-8 [6847771] Carcinogenesis. 1983;4(5):577-81 [6850990] Science. 1983 Sep 23;221(4617):1285-8 [6137059] Cancer Res. 1983 Nov;43(11):5049-58 [6137276] Cancer Res. 1984 Jun;44(6):2698-703 [6722802] Nature. 1984 Jun 14-20;309(5969):626-8 [6728022] Can J Biochem Cell Biol. 1984 Jun;62(6):486-94 [6380687] Cancer Res. 1984 Dec;44(12 Pt 1):5463-74 [6388826] Cancer Res. 1985 Feb;45(2):564-71 [2857108] Somat Cell Mol Genet. 1985 Mar;11(2):117-26 [3856953] Cancer Res. 1985 Jul;45(7):3002-7 [4005839] Nucleic Acids Res. 1985 Sep 11;13(17):6049-57 [2995915] Proc Natl Acad Sci U S A. 1986 Jan;83(2):337-41 [3455770] Science. 1986 May 9;232(4751):751-5 [2421411] Carcinogenesis. 1986 Apr;7(4):523-8 [3698185] Jpn J Cancer Res. 1986 Mar;77(3):226-9 [3084412] J Biol Chem. 1986 May 15;261(14):6137-40 [3700389] Proc Natl Acad Sci U S A. 1986 Jun;83(12):4538-42 [3459187] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. AN - 81088491; 3672526 AB - A rapid decrease in male fertility in laboratory animals exposed to 1,2-dibromo-3-chloropropane (DBCP) has been suggested to be due, in part, to a postglycolytic inhibition of sperm carbohydrate metabolism. The present studies were performed to identify the specific site of DBCP-induced inhibition of intermediary metabolism. 14CO2 generation by epididymal sperm, isolated from Fischer 344 rats, was measured using radiolabeled tricarboxylic acid (TCA) cycle intermediates: acetyl CoA, citrate, alpha-ketoglutarate, and succinate. There was 0-28% inhibition of CO2 generation after addition of 0.5 mM DBCP and 81-98% inhibition with 3 mM DBCP, with all four substrates. The activities of alpha-ketoglutarate dehydrogenase, pyruvate dehydrogenase, malate dehydrogenase, and lactate dehydrogenase were not inhibited by DBCP. Since the DBCP-induced inhibition of metabolism of different substrates to CO2 was similar, and since DBCP did not inhibit enzyme activities of glycolysis or the TCA cycle, a common site of inhibition was suspected. In evaluations of mitochondrial electron transport chain activity, DBCP (3 mM) inhibited oxygen consumption resulting from metabolism of endogenous substrates plus alpha-ketoglutarate or malate by about 80%. When succinate, an FAD-dependent oxidation, was used as a substrate, oxygen consumption was not inhibited by DBCP. It is concluded that DBCP inhibits sperm carbohydrate metabolism at the NADH dehydrogenase step in the mitochondrial electron transport chain. JF - Toxicology and applied pharmacology AU - Greenwell, A AU - Tomaszewski, K E AU - Melnick, R L AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 274 EP - 280 VL - 91 IS - 2 SN - 0041-008X, 0041-008X KW - Insecticides KW - 0 KW - 1,2-dibromo-3-chloropropane KW - 96K0FD4803 KW - Oxidoreductases KW - EC 1.- KW - Propane KW - T75W9911L6 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Oxygen Consumption -- drug effects KW - Oxidoreductases -- metabolism KW - Electron Transport KW - Kinetics KW - In Vitro Techniques KW - Male KW - Propane -- toxicity KW - Insecticides -- toxicity KW - Spermatozoa -- drug effects KW - Propane -- analogs & derivatives KW - Spermatozoa -- metabolism KW - Infertility, Male -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81088491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=A+biochemical+basis+for+1%2C2-dibromo-3-chloropropane-induced+male+infertility%3A+inhibition+of+sperm+mitochondrial+electron+transport+activity.&rft.au=Greenwell%2C+A%3BTomaszewski%2C+K+E%3BMelnick%2C+R+L&rft.aulast=Greenwell&rft.aufirst=A&rft.date=1987-11-01&rft.volume=91&rft.issue=2&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-11 N1 - Date created - 1987-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Exogenous O6-methylguanine inhibits adduct removal and sensitizes human cells to killing by the chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine. AN - 81087207; 3670328 AB - We partially depleted the O6-methylguanine-DNA methyltransferase activity in four O6-methylguanine (O6-mGua) repair-proficient (Mer+) human cell strains with exogenous O6-mGua (2 mM for 3 h, a non-toxic regimen) and then challenged them with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). MT-partially depleted HT29 cells removed O6-mGua from DNA at about half the rate of control cells, while removal of 3-methyladenine was unaffected. In spite of partial depletion of MT, however, cell killing by MNNG in a colony-forming assay with HT29, A549, A498 or KD cells was not greatly affected. (This is in contrast to the dramatic potentiation of CNU cytotoxicity observed previously.) In an attempt to sensitize Mer+ strains to killing by MNNG, we treated cells with O6-mGua following MNNG exposure (0.4 mM for 4 days), in addition to the pre-MNNG treatment of 2 mM O6-mGua for 3 h. This sensitized KD and HT29 cells 2-fold to killing by MNNG, based on the dose at 10% survival, but did not sensitive Mer- A1336. However, post-treatment alone was as effective as combined pre- and post-treatment in sensitizing KD cells to killing. Thus, when the O6-mGua post-treatment was begun, greater than 50% of O6-mGua was already removed from cell DNA. Our findings may be accounted for by at least two schemes, one in which nonlethal O6-mGua are removed from DNA rapidly, while potentially lethal O6-mGua are repaired later. The other scheme proposes that exogenous O6-mGua increases the lethality of a non-O6-mGua lesion by reducing its repair both in Mer+ and Mer- cells. Both schemes are consistent with the hypothesis that O6-mGua may be a lethal DNA lesion in human cells. JF - Mutation research AU - Babich, M A AU - Day, R S AD - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, MD. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 245 EP - 254 VL - 184 IS - 3 SN - 0027-5107, 0027-5107 KW - Methylnitronitrosoguanidine KW - 12H3O2UGSF KW - Guanine KW - 5Z93L87A1R KW - O-(6)-methylguanine KW - 9B710FV2AE KW - Methyltransferases KW - EC 2.1.1.- KW - O(6)-Methylguanine-DNA Methyltransferase KW - EC 2.1.1.63 KW - Index Medicus KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Humans KW - Methyltransferases -- metabolism KW - Methylnitronitrosoguanidine -- toxicity KW - DNA Damage KW - Guanine -- analogs & derivatives KW - Guanine -- pharmacology KW - DNA Repair -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81087207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Exogenous+O6-methylguanine+inhibits+adduct+removal+and+sensitizes+human+cells+to+killing+by+the+chemical+carcinogen+N-methyl-N%27-nitro-N-nitrosoguanidine.&rft.au=Babich%2C+M+A%3BDay%2C+R+S&rft.aulast=Babich&rft.aufirst=M&rft.date=1987-11-01&rft.volume=184&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-09 N1 - Date created - 1987-12-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mutagenic activity of 27 dyes and related chemicals in the salmonella/microsome and mouse lymphoma TK+/- assays. AN - 81087086; 3313036 AB - A total of 27 dyes and related chemicals were tested for mutagenicity in both the Salmonella typhimurium plate-incorporation and FMN-modified assays as well as the mouse lymphoma TK+/- assay. Half of the compounds tested were monoazo dyes (14); the remainder consisted of disazo (3), aminotriphenylmethane derivatives (4), and other miscellaneous (6) color compounds. The results obtained in this study are compared with data from dyes of the same batch tested in other laboratories in the Salmonella plate-incorporation assay and in both in vitro and in vivo/in vitro UDS assays. Agreement of results from the various assays that could be compared (excluding results that were equivocal or indeterminate) ranged from 80 to 91%. Sufficient data were available to provide an overall index of in vitro activity for 15 chemicals; of these, 14 compounds could be compared to and agreed with reports of their carcinogenic potential in the literature. JF - Mutation research AU - Cameron, T P AU - Hughes, T J AU - Kirby, P E AU - Fung, V A AU - Dunkel, V C AD - National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 223 EP - 261 VL - 189 IS - 3 SN - 0027-5107, 0027-5107 KW - Coloring Agents KW - 0 KW - Neoplasm Proteins KW - Thymidine Kinase KW - EC 2.7.1.21 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Leukemia L5178 -- genetics KW - Neoplasm Proteins -- genetics KW - Mesocricetus KW - Mice KW - Leukemia L5178 -- enzymology KW - Male KW - Thymidine Kinase -- genetics KW - Cricetinae KW - Coloring Agents -- pharmacology KW - Tumor Cells, Cultured -- drug effects KW - Salmonella typhimurium -- drug effects KW - Tumor Cells, Cultured -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81087086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Mutagenic+activity+of+27+dyes+and+related+chemicals+in+the+salmonella%2Fmicrosome+and+mouse+lymphoma+TK%2B%2F-+assays.&rft.au=Cameron%2C+T+P%3BHughes%2C+T+J%3BKirby%2C+P+E%3BFung%2C+V+A%3BDunkel%2C+V+C&rft.aulast=Cameron&rft.aufirst=T&rft.date=1987-11-01&rft.volume=189&rft.issue=3&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-02 N1 - Date created - 1987-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunosuppression by succinylacetone. II. Prevention of graft-vs-host disease. AN - 81065037; 2889780 AB - Succinylacetone is a seven-carbon organic ketoacid that we have previously shown to inhibit tumor allograft rejection as well as the primary antibody response to sheep erythrocytes in rats. Because it appeared to be such a potent immunosuppressive agent in our initial studies, we evaluated succinylacetone for its ability to block graft-vs-host disease (GVHD) in adult F1 rats injected with parental strain spleen cells. Untreated ACE X Lewis F1 rats given Lewis strain spleen cells died of GVHD, with a mean survival of 24 days. By contrast, 62% of F1 rats in the group treated with succinylacetone survived, and the deaths that occurred in this group occurred significantly later. To confirm this observation and determine whether succinylacetone would interfere with bone marrow engraftment, lethally irradiated adult Wistar-Furth rats were reconstituted with syngeneic or totally allogeneic Fisher 344 lymphohemopoietic cells consisting of equal numbers of bone marrow and spleen cells. All animals given allogeneic cells without additional immunosuppressive treatment developed severe GVHD and died by day 42. By contrast 92% of the allogeneic cell recipients that had been treated with succinylacetone were long term survivors. Cytotoxicity typing of peripheral lymphocytes demonstrated greater than 90% donor-type lymphocytes persisting in the succinylacetone-treated recipients as long as 255 days post-transplantation. No chronic or late developing acute GVHD was observed even though the animals received succinylacetone as the sole immunosuppressant for only 28 days after transplantation. Furthermore, hemopoietic reconstitution in recipients of syngeneic cells was essentially identical between the control group and the group treated with succinylacetone. In addition, no gross or histologic evidence for renal, hepatic, cardiovascular, endocrine, or neurologic toxicity was observed in the long term transplant survivors treated with succinylacetone. These data indicate that succinylacetone treatment is effective in preventing lethal GVHD in this allogeneic bone marrow transplantation system while permitting normal hemopoietic reconstitution in the absence of significant chronic toxicity to other major organ systems. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Hess, R A AU - Tschudy, D P AU - Blaese, R M AD - Metabolism Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/11/01/ PY - 1987 DA - 1987 Nov 01 SP - 2845 EP - 2849 VL - 139 IS - 9 SN - 0022-1767, 0022-1767 KW - Heptanoates KW - 0 KW - Heptanoic Acids KW - succinylacetone KW - 51568-18-4 KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Chimera KW - Cell Survival -- drug effects KW - Hematopoiesis -- drug effects KW - Male KW - Bone Marrow Transplantation KW - Spleen -- transplantation KW - Graft vs Host Reaction -- drug effects KW - Graft vs Host Disease -- pathology KW - Heptanoates -- pharmacology KW - Hematopoietic Stem Cell Transplantation KW - Graft vs Host Disease -- prevention & control KW - Heptanoates -- toxicity KW - Immunosuppression KW - Heptanoic Acids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81065037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Immunosuppression+by+succinylacetone.+II.+Prevention+of+graft-vs-host+disease.&rft.au=Hess%2C+R+A%3BTschudy%2C+D+P%3BBlaese%2C+R+M&rft.aulast=Hess&rft.aufirst=R&rft.date=1987-11-01&rft.volume=139&rft.issue=9&rft.spage=2845&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-25 N1 - Date created - 1987-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A precursor-product relationship exists between oval cells and hepatocytes in rat liver. AN - 81062638; 3664968 AB - Oval cell proliferation was induced in twelve male Fischer rats by administration of 2-acetylaminofluorene (2-AAF) for 2 weeks and by performing partial hepatectomy one week after the beginning of 2-AAF administration. Albumin expression in liver was studied by using in situ hybridization of 3H-labeled rat albumin riboprobe. Radiolabeled thymidine was administered to a group of animals at day 6 after partial hepatectomy. The animals were killed at 0, 3, 7, 9, 11 and 13 days after partial hepatectomy. Both oval cells and basophilic hepatocytes showed a prominent expression of albumin, whereas albumin expression in acidophilic pre-existing hepatocytes was decreased. Oval cell nuclei were exclusively labeled one day after administration of [3H]thymidine. At day 9, 11 and 13 basophilic hepatocytes became labeled and the area occupied by these cells increased. This is the first demonstration of the transfer of radiolabeled thymidine from oval cells to newly formed hepatocytes in vivo. Thus the precursor-product relationship between oval cells and basophilic hepatocytes has been established. JF - Carcinogenesis AU - Evarts, R P AU - Nagy, P AU - Marsden, E AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 1737 EP - 1740 VL - 8 IS - 11 SN - 0143-3334, 0143-3334 KW - Albumins KW - 0 KW - RNA, Messenger KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Thymidine -- metabolism KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Liver Neoplasms, Experimental -- etiology KW - Hepatectomy KW - Albumins -- genetics KW - RNA, Messenger -- analysis KW - Cell Division -- drug effects KW - Male KW - Liver -- cytology KW - Liver -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81062638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=A+precursor-product+relationship+exists+between+oval+cells+and+hepatocytes+in+rat+liver.&rft.au=Evarts%2C+R+P%3BNagy%2C+P%3BMarsden%2C+E%3BThorgeirsson%2C+S+S&rft.aulast=Evarts&rft.aufirst=R&rft.date=1987-11-01&rft.volume=8&rft.issue=11&rft.spage=1737&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-07 N1 - Date created - 1987-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Stereoselectivity of cytosolic glutathione S-transferases with arene and alkene oxide substrates in various tissues and isolated hepatic and pulmonary cells of the rabbit. AN - 81060898; 3664952 AB - The specific activity and stereoselectivity of cytosolic glutathione S-transferases (GST) from various rabbit tissues and isolated cells were determined as an initial step in characterizing GST isoenzymes in the rabbit. Of the five tissues examined, liver cytosol had the highest specific GST activity with the polycyclic arene oxides (+/-)-benzo[a]pyrene 4,5-oxide (BPO), pyrene 4,5-oxide (PO) and (+/-)-benz[a]-anthracene 5,6-oxide (BAO), and kidney cytosol had the second highest. Lung, intestine and testis had relatively low activities with all three substrates. With the alkene oxide (+/-)-styrene 7,8-oxide (SO), testicular cytosol had the highest GST activity while liver cytosol had only half the activity of the testis. Cytosolic GST from liver and kidney were highly stereoselective for reaction of glutathione with the S-configured oxirane carbon atoms of BPO, PO and BAO, and all tissues but the intestine were enantioselective for (4R,5S)-BPO and (5S,6R)-BAO. With SO, the liver, kidney and testis preferentially catalyzed the reaction of glutathione with the benzylic carbon atom of (7S)-SO. There was virtually no enantioselectivity in lung cytosol with SO but a preference for reaction with (7R)-SO was noted in the intestine. The stereoselectivities found in the intestine with each of the four substrates were markedly different from the other tissues. Cytosol from isolated hepatocytes showed almost identical patterns of stereoselectivity with BPO and PO to those of whole liver cytosol. Similarly, the stereoselectivity of cytosol prepared from alveolar type II cells isolated from rabbit lung was the same as that of whole lung cytosol with these substrates, whereas cytosol of alveolar macrophages differed substantially from lung cytosol in both cases. There were marked differences in stereoselectivity of cytosol from freshly isolated Clara cells with BPO versus PO as substrate. With BPO, Clara cells were very similar to whole lung cytosol, but with PO they were not. The data are consistent with the differential tissue and cellular distribution of multiple GST isoenzymes in the rabbit. JF - Carcinogenesis AU - Dostal, L A AU - Horton, J K AU - Harris, C AU - Brier, D F AU - Bend, J R AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 1601 EP - 1606 VL - 8 IS - 11 SN - 0143-3334, 0143-3334 KW - Benz(a)Anthracenes KW - 0 KW - Benzopyrenes KW - Pyrenes KW - pyrene 4,5-oxide KW - 37496-00-7 KW - benzo(a)pyrene 4,5-epoxide KW - 37574-47-3 KW - benzanthracene-5,6-oxide KW - 790-60-3 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Macrophages -- enzymology KW - Animals KW - Stereoisomerism KW - Pyrenes -- metabolism KW - Kidney -- enzymology KW - Rabbits KW - Benzopyrenes -- metabolism KW - Benz(a)Anthracenes -- metabolism KW - Male KW - Liver -- enzymology KW - Cytosol -- enzymology KW - Lung -- enzymology KW - Glutathione Transferase -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81060898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Stereoselectivity+of+cytosolic+glutathione+S-transferases+with+arene+and+alkene+oxide+substrates+in+various+tissues+and+isolated+hepatic+and+pulmonary+cells+of+the+rabbit.&rft.au=Dostal%2C+L+A%3BHorton%2C+J+K%3BHarris%2C+C%3BBrier%2C+D+F%3BBend%2C+J+R&rft.aulast=Dostal&rft.aufirst=L&rft.date=1987-11-01&rft.volume=8&rft.issue=11&rft.spage=1601&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-07 N1 - Date created - 1987-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of intercellular communication by nickel(II): antagonistic effect of magnesium. AN - 81058915; 3664971 AB - The level of gap-junctional (cell-cell) communication was studied by the radioisotope transfer technique in NIH 3T3 cells exposed to NiSO4, MgSO4, or both salts combined. Monolayered NIH 3T3 donor cells were labeled with [3H]-uridine for 3 h and then co-cultured with non-labeled recipient NIH 3T3 cells for 3 h in the presence of 0.5-20 mM NiSO4, 1.0-100 mM MgSO4, or 5 mM NiSO4 plus 1.0-100 mM MgSO4. 12-O-tetradecanoylphorbol-13-acetate (TPA), 16-160 pM, served as a positive control. The exposed cells were fixed with 2.5% glutaraldehyde and processed for autoradiography. The cell-cell communication rate was based on the number of radioactive recipient cells in relation to the total number of recipient cells for 100 donor cells. NiSO4 disrupted cell-cell communication in a dose-related manner from 98% of the base value at 0.5 mM NiSO4 to 2% at 5 mM NiSO4. Cell viability was not affected by 0.5-5 mM NiSO4. The inhibitory action of 5 mM NiSO4 could be partially prevented by 5.0-100 mM MgSO4. However, MgSO4 did not prevent the inhibition by TPA. The results indicate that NiSO4 is capable of inhibiting cell-cell communication at concentrations that do not cause cytotoxic effects in NIH 3T3 cells during a 3-h period. In this respect NiSO4 resembles such classical tumor promoters like TPA. The antagonism by magnesium of the nickel-induced inhibition of cell-cell communication may indicate a contributory mechanism by which magnesium counteracts the carcinogenicity of nickel in vivo. JF - Carcinogenesis AU - Miki, H AU - Kasprzak, K S AU - Kenney, S AU - Heine, U I AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, MD 21701-1013. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 1757 EP - 1760 VL - 8 IS - 11 SN - 0143-3334, 0143-3334 KW - Nickel KW - 7OV03QG267 KW - Magnesium KW - I38ZP9992A KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Nickel -- antagonists & inhibitors KW - Cell Communication -- drug effects KW - Magnesium -- pharmacology KW - Nickel -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81058915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Inhibition+of+intercellular+communication+by+nickel%28II%29%3A+antagonistic+effect+of+magnesium.&rft.au=Miki%2C+H%3BKasprzak%2C+K+S%3BKenney%2C+S%3BHeine%2C+U+I&rft.aulast=Miki&rft.aufirst=H&rft.date=1987-11-01&rft.volume=8&rft.issue=11&rft.spage=1757&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-07 N1 - Date created - 1987-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: a new class of cholesterol-lowering agents. AN - 81051438; 3662286 JF - Annals of internal medicine AU - Gordon, D J AU - Rifkind, B M AD - National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 759 EP - 761 VL - 107 IS - 5 SN - 0003-4819, 0003-4819 KW - Anticholesteremic Agents KW - 0 KW - Cholesterol, LDL KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Lovastatin KW - 9LHU78OQFD KW - Abridged Index Medicus KW - Index Medicus KW - Lovastatin -- adverse effects KW - Cholesterol, LDL -- blood KW - Coronary Disease -- prevention & control KW - Lovastatin -- therapeutic use KW - Humans KW - Anticholesteremic Agents -- therapeutic use KW - Anticholesteremic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81051438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=3-Hydroxy-3-methylglutaryl+coenzyme+A+%28HMG-CoA%29+reductase+inhibitors%3A+a+new+class+of+cholesterol-lowering+agents.&rft.au=Gordon%2C+D+J%3BRifkind%2C+B+M&rft.aulast=Gordon&rft.aufirst=D&rft.date=1987-11-01&rft.volume=107&rft.issue=5&rft.spage=759&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-20 N1 - Date created - 1987-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Induction of multiple replacement mutations by oligonucleotide-directed mutagenesis with extended mismatch primers. AN - 78072180; 3333763 AB - We have developed a method called oligo-scanning mutagenesis that uses oligonucleotides to mutate up to 12 contiguous bases in a single step. Some advantages of this procedure are that the position and sequence of the replacement mutations are completely specified by the investigator, and combinations of mutations can easily be generated. The technique uses a gapped substrate and the Escherichia coli dam methylation error-correcting mechanism to increase the yield of mutants. JF - Gene analysis techniques AU - Lichtler, A AU - Hager, G L AD - Hormone Action and Oncogenesis Section, National Cancer Institute, Bethesda, Maryland. PY - 1987 SP - 111 EP - 118 VL - 4 IS - 6 SN - 0735-0651, 0735-0651 KW - DNA, Viral KW - 0 KW - Oligonucleotides KW - Index Medicus KW - Base Sequence KW - Molecular Sequence Data KW - Genetic Engineering -- methods KW - Nucleic Acid Hybridization KW - Methylation KW - Escherichia coli -- genetics KW - Coliphages -- genetics KW - Mutation KW - DNA, Viral -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78072180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+analysis+techniques&rft.atitle=Induction+of+multiple+replacement+mutations+by+oligonucleotide-directed+mutagenesis+with+extended+mismatch+primers.&rft.au=Lichtler%2C+A%3BHager%2C+G+L&rft.aulast=Lichtler&rft.aufirst=A&rft.date=1987-11-01&rft.volume=4&rft.issue=6&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Gene+analysis+techniques&rft.issn=07350651&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-28 N1 - Date created - 1989-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Control of c-fos and c-myc proto-oncogene induction in rat thyroid cells in culture. AN - 78064983; 2856403 AB - Removal of TSH, insulin, and cortisol from the medium, and decreasing the serum content to 0.2%, abolishes both the proliferate and differentiated state of FRTL-5 rat thyroid cells in culture. In these basal conditions, the individual addition of TSH, insulin, insulin-like growth factor-I (IGF-I), phorbol 12-myristate 13-acetate (TPA), alpha 1-adrenergic agents, or A23187, increase c-myc and/or c-fos proto-oncogene expression. Under the same conditions, only the addition of TSH increased cAMP levels; 8-bromo-cAMP can increase c-myc or c-fos mRNA levels. Pretreatment of cells with phorbol 12,13-dibutyrate, an agent which down regulates the C-kinase, completely inhibits the effect of TPA on proto-oncogene expression but has no affect on the A23187 induced-increase. The sum of these results indicate that at least four separate signal systems independently increase c-myc or c-fos gene expression in FRTL-5 cells cAMP (TSH), C-kinase (TPA), Ca++/phosphoinositide (A23187), and that influenced by insulin/IGF-I. None of the ligands, when individually returned to cells in basal medium (no TSH, insulin, or cortisol and only 0.2% serum), increases cell number; norepinephrine, and A23187 do not increase [3H]thymidine incorporation into DNA under these conditions; and combinations of the ligands can be more than additive in effecting [3H]thymidine incorporation into DNA but are only additive in effecting proto-oncogene expression. Insulin/IGF-I plus TSH or insulin/IGF-I plus norepinephrine can increase both proto-oncogene expression and [3H]thymidine incorporation into DNA to the same extent; however, the former combination can increase cell number whereas the latter cannot. There is therefore no simple correlation between the ability of the above ligands to increase proto-oncogene expression and their ability to increase cell number or induce DNA synthesis. Under conditions where insulin and IGF-I increase proto-oncogene expression but not cell number, they can increase thyroglobulin gene expression. In the presence of TSH, insulin and IGF-I are not additive with each other in their ability to increase thyroglobulin or proto-oncogene gene expression but are additive in their ability to increase cell number. Proto-oncogene expression in FRTL-5 rat thyroid cells, as in other cell systems, may thus be related to functional as well as proliferative responses. JF - Molecular endocrinology (Baltimore, Md.) AU - Isozaki, O AU - Kohn, L D AD - Section on Cell Regulation, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 839 EP - 848 VL - 1 IS - 11 SN - 0888-8809, 0888-8809 KW - c-fos KW - c-myc KW - Insulin KW - 0 KW - RNA, Messenger KW - Tritium KW - 10028-17-8 KW - Calcimycin KW - 37H9VM9WZL KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Thyrotropin KW - 9002-71-5 KW - DNA KW - 9007-49-2 KW - Thyroglobulin KW - 9010-34-8 KW - Cyclic AMP KW - E0399OZS9N KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Thymidine KW - VC2W18DGKR KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Animals KW - Thyroglobulin -- biosynthesis KW - Norepinephrine -- pharmacology KW - Genes, myc KW - Cell Division -- drug effects KW - Insulin -- pharmacology KW - Calcimycin -- pharmacology KW - DNA -- biosynthesis KW - Insulin-Like Growth Factor I -- pharmacology KW - Thymidine -- metabolism KW - Rats KW - Thyrotropin -- pharmacology KW - RNA, Messenger -- metabolism KW - Cell Count -- drug effects KW - Cyclic AMP -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Cell Division -- genetics KW - Cell Line KW - Proto-Oncogenes -- genetics KW - Thyroid Gland -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78064983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Control+of+c-fos+and+c-myc+proto-oncogene+induction+in+rat+thyroid+cells+in+culture.&rft.au=Isozaki%2C+O%3BKohn%2C+L+D&rft.aulast=Isozaki&rft.aufirst=O&rft.date=1987-11-01&rft.volume=1&rft.issue=11&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-05 N1 - Date created - 1990-12-05 N1 - Date revised - 2017-01-13 N1 - Gene symbol - c-fos; c-myc N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Morphology and classification of 96 primary cardiac neoplasms in Fischer 344 rats. AN - 78060703; 3455078 AB - Ninety-six primary cardiac neoplasms were identified from 79,971 Fischer 344 (F344) rats used in chronic toxicity and carcinogenicity studies by the National Toxicology Program (NTP) and National Cancer Institute (NCI), for an overall incidence of 0.1%. Neoplasms were classified as: 60 endocardial schwannomas, 23 intramural schwannomas, eight atriocaval mesotheliomas, three paragangliomas, one pericardial mesothelioma, and one hemangioma. Metastases occurred in four rats with endocardial schwannoma. Histological appearance of the endocardial and intramural schwannomas was consistent with origin from nerve sheath. Two of six endocardial schwannomas available for immunohistochemical staining were weakly positive for S-100 antigen. The atriocaval mesotheliomas, while morphologically resembling adenocarcinoma, were positive for vimentin and keratin, indicating mesothelial origin. Seventy of the 96 cardiac neoplasms occurred in rats 2 years of age or older at time of death. There were no sex or treatment-related differences in the incidence of these neoplasms, with the exception of atriocaval mesothelioma, which was more common in males. JF - Veterinary pathology AU - Alison, R H AU - Elwell, M R AU - Jokinen, M P AU - Dittrich, K L AU - Boorman, G A AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 488 EP - 494 VL - 24 IS - 6 SN - 0300-9858, 0300-9858 KW - Index Medicus KW - Animals KW - Heart Septum KW - Paraganglioma -- pathology KW - Endocardium KW - Hemangioma -- veterinary KW - Rats KW - Hemangioma -- classification KW - Hemangioma -- pathology KW - Mesothelioma -- veterinary KW - Mesothelioma -- classification KW - Paraganglioma -- classification KW - Mesothelioma -- pathology KW - Paraganglioma -- veterinary KW - Pericardium KW - Female KW - Heart Atria KW - Heart Ventricles KW - Male KW - Rats, Inbred Strains KW - Neurilemmoma -- classification KW - Rats, Inbred F344 KW - Heart Neoplasms -- classification KW - Heart Neoplasms -- pathology KW - Neurilemmoma -- veterinary KW - Neurilemmoma -- pathology KW - Rodent Diseases -- classification KW - Heart Neoplasms -- veterinary KW - Rodent Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78060703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+pathology&rft.atitle=Morphology+and+classification+of+96+primary+cardiac+neoplasms+in+Fischer+344+rats.&rft.au=Alison%2C+R+H%3BElwell%2C+M+R%3BJokinen%2C+M+P%3BDittrich%2C+K+L%3BBoorman%2C+G+A&rft.aulast=Alison&rft.aufirst=R&rft.date=1987-11-01&rft.volume=24&rft.issue=6&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Veterinary+pathology&rft.issn=03009858&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-27 N1 - Date created - 1988-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recent advances in the treatment of systemic fungal infections. AN - 78009066; 2834615 AB - Systemic fungal infections are life-threatening diseases that are occurring with increasing frequency, especially in immunocompromised patients. Advances in the treatment of systemic fungal infections have been achieved through better understanding of two classic antifungal drugs, amphotericin B and flucytosine, and through the recent development of several antifungal azole derivatives. The purpose of this paper is to review the recent advances in pharmacology, toxicology, formulation and clinical trials of antifungal agents for the treatment of systemic mycoses. JF - Methods and findings in experimental and clinical pharmacology AU - Walsh, T J AD - Pediatric Branch, National Cancer Institute, Bethesda, Maryland. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 769 EP - 778 VL - 9 IS - 11 SN - 0379-0355, 0379-0355 KW - Antifungal Agents KW - 0 KW - Triazoles KW - Itraconazole KW - 304NUG5GF4 KW - Miconazole KW - 7NNO0D7S5M KW - Amphotericin B KW - 7XU7A7DROE KW - Fluconazole KW - 8VZV102JFY KW - Flucytosine KW - D83282DT06 KW - Ketoconazole KW - R9400W927I KW - Index Medicus KW - AIDS/HIV KW - Miconazole -- therapeutic use KW - Drug Therapy, Combination KW - Acquired Immunodeficiency Syndrome -- complications KW - Ketoconazole -- therapeutic use KW - Humans KW - Ketoconazole -- analogs & derivatives KW - Drug Resistance, Microbial KW - Triazoles -- therapeutic use KW - Amphotericin B -- therapeutic use KW - Flucytosine -- therapeutic use KW - Antifungal Agents -- pharmacokinetics KW - Antifungal Agents -- adverse effects KW - Mycoses -- drug therapy KW - Antifungal Agents -- administration & dosage KW - Mycoses -- etiology KW - Antifungal Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78009066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+and+findings+in+experimental+and+clinical+pharmacology&rft.atitle=Recent+advances+in+the+treatment+of+systemic+fungal+infections.&rft.au=Walsh%2C+T+J&rft.aulast=Walsh&rft.aufirst=T&rft.date=1987-11-01&rft.volume=9&rft.issue=11&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Methods+and+findings+in+experimental+and+clinical+pharmacology&rft.issn=03790355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-27 N1 - Date created - 1988-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunomodulatory and therapeutic properties of alkyl lysophospholipids in mice. AN - 77986874; 3502167 AB - This paper describes the immunomodulatory and therapeutic properties of the alkyl lysophospholipids [ALP; 1-O-octadecyl-2-O-rac-glycero-3-phosphocholine (ET-18-OCH3)]. ALP was able to activate macrophages both in vitro and in vivo as well as to act as an immunoadjuvant for syngeneic tumor vaccines. However, ALP appeared to be transferred, at least in part, to the macrophage membrane, and some of the tumoricidal macrophage-activating properties seem to be associated with the direct cytotoxic effect of membrane-released ALP. ALP also had some therapeutic activity for experimental and spontaneous metastases, requiring administration three but not two times weekly at near-toxic doses; this suggests that at least some of its therapeutic activity is due to direct cytotoxicity. JF - Lipids AU - Talmadge, J E AU - Schneider, M AU - Lenz, B AU - Phillips, H AU - Long, C AD - Preclinical Screening Laboratory, National Cancer Institute-Frederick Cancer Research Facility, Maryland. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 871 EP - 877 VL - 22 IS - 11 SN - 0024-4201, 0024-4201 KW - Antineoplastic Agents KW - 0 KW - Lysophospholipids KW - Phospholipid Ethers KW - edelfosine KW - 1Y6SNA8L5S KW - Index Medicus KW - Animals KW - Macrophages -- immunology KW - Spleen -- cytology KW - Dose-Response Relationship, Drug KW - Mice KW - Macrophages -- drug effects KW - Killer Cells, Natural -- drug effects KW - Cells, Cultured KW - Mice, Inbred C3H KW - Mice, Inbred C57BL KW - Neoplasm Metastasis KW - Spleen -- immunology KW - Cytotoxicity Tests, Immunologic KW - Spleen -- drug effects KW - Male KW - Antineoplastic Agents -- immunology KW - Lysophospholipids -- toxicity KW - Phospholipid Ethers -- toxicity KW - Phospholipid Ethers -- therapeutic use KW - Phospholipid Ethers -- immunology KW - Lysophospholipids -- therapeutic use KW - T-Lymphocytes -- drug effects KW - Lysophospholipids -- immunology KW - Antineoplastic Agents -- therapeutic use KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77986874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lipids&rft.atitle=Immunomodulatory+and+therapeutic+properties+of+alkyl+lysophospholipids+in+mice.&rft.au=Talmadge%2C+J+E%3BSchneider%2C+M%3BLenz%2C+B%3BPhillips%2C+H%3BLong%2C+C&rft.aulast=Talmadge&rft.aufirst=J&rft.date=1987-11-01&rft.volume=22&rft.issue=11&rft.spage=871&rft.isbn=&rft.btitle=&rft.title=Lipids&rft.issn=00244201&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-12 N1 - Date created - 1988-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Electrophysiological evidence for a non-opioid interaction between dynorphin and GABA in the substantia nigra of the rat. AN - 77954511; 2893989 AB - Interactions between neuronal responses mediated by dynorphin A1-8 and GABA were investigated in the substantia nigra zona reticulata. Extracellular recordings and microiontophoresis were performed using five-barrel microelectrodes in chloral hydrate-anesthetized male rats. When iontophoresed alone, dynorphin A1-Q significantly inhibited the firing of 22% of the neurons tested. The inhibition was rapid in onset and recovery and was dose-dependent. In another 22% of the cells, iontophoretic dynorphin produced an increase in the baseline firing rate which was slow in both onset and offset; the remaining 56% were unaffected by dynorphin. When GABA and dynorphin A1-8 were applied in conjunction, the inhibitory action of GABA was attenuated in 61% of the cells; whereas, when dynorphin and GABA were ejected simultaneously onto the cells that were inhibited by dynorphin A1-8, the respective inhibitory effects of dynorphin and GABA appeared to be additive. The kappa antagonist, MR-2266, failed to block the ability of dynorphin A1-8 to attenuate the action of GABA. In addition, the non-opiate peptide des-tyr-dynorphin A2-17, produced effects similar to that of dynorphin A1-8. The role of dynorphin in the basal ganglia and its interaction with the other major transmitter in the substantia nigra zona reticulata, GABA, is discussed. JF - Neuroscience AU - Robertson, B C AU - Hommer, D W AU - Skirboll, L R AD - Electrophysiology Unit, NIMH, Bethesda, MD 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 483 EP - 490 VL - 23 IS - 2 SN - 0306-4522, 0306-4522 KW - Benzomorphans KW - 0 KW - Peptide Fragments KW - Receptors, Opioid KW - Naloxone KW - 36B82AMQ7N KW - Sodium Chloride KW - 451W47IQ8X KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - MR 2266 KW - 56649-76-4 KW - Dynorphins KW - 74913-18-1 KW - dynorphin (1-8) KW - 75790-53-3 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Benzomorphans -- administration & dosage KW - Naloxone -- pharmacology KW - Naloxone -- administration & dosage KW - Animals KW - Drug Interactions KW - Benzomorphans -- pharmacology KW - Injections, Intravenous KW - Action Potentials -- drug effects KW - Male KW - Sodium Chloride -- pharmacology KW - gamma-Aminobutyric Acid -- pharmacology KW - Receptors, Opioid -- drug effects KW - Peptide Fragments -- pharmacology KW - Substantia Nigra -- drug effects KW - Substantia Nigra -- physiology KW - Dynorphins -- analogs & derivatives KW - Receptors, Opioid -- physiology KW - Dynorphins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77954511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Electrophysiological+evidence+for+a+non-opioid+interaction+between+dynorphin+and+GABA+in+the+substantia+nigra+of+the+rat.&rft.au=Robertson%2C+B+C%3BHommer%2C+D+W%3BSkirboll%2C+L+R&rft.aulast=Robertson&rft.aufirst=B&rft.date=1987-11-01&rft.volume=23&rft.issue=2&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-28 N1 - Date created - 1988-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Behavioral indices of neurotoxicity: what can be measured? AN - 77940117; 3325803 AB - The ability to identify and characterize the potential neurotoxicity of chemicals is an important and necessary function of various regulatory agencies. Behavioral assessments of toxicity may be important because of their relative sensitivity to some chemicals, their generally noninvasive characteristics, and their ability to measure toxicity in organ systems other than the nervous system. Behavioral tests can be classified by several criteria including traditional experimental definitions, their desired experimental usage, the neurobehavioral functions they are designed to assess, and the strategy chosen for their use in the evaluation of chemicals. Examples of neurobehavioral tests used to evaluate the effects of chemicals for toxicity include those that evaluate motor (spontaneous motor activity, motor coordination, weakness, abnormal movement or posture, tremor, and on-going performance), sensory (screening, reflex modification, and instrumental conditioning), learning/memory (nonassociative and associative), instrumental performance (schedules of reinforcement), and naturally occurring responses (consummatory behaviors). Behavioral procedures have also been utilized in select ways in toxicological research to detect latent damage, to study mechanisms of action, and to screen for functional dysfunction following exposure during development. Many considerations, such as the behavioral mechanism of action, definition of an adverse effect, problem of functional reserve, and several statistical questions, should be taken into account in the use and interpretation of data obtained from behavioral tests. During the last decade, there have been numerous recommendations from groups within the United States and, most recently, the World Health Organization, suggesting that systematic observational assessments may be appropriate when carried out within already existing toxicological protocols. JF - Neurotoxicology and teratology AU - Tilson, H A AD - Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC. PY - 1987 SP - 427 EP - 443 VL - 9 IS - 6 SN - 0892-0362, 0892-0362 KW - Index Medicus KW - Animals KW - Humans KW - Behavior -- drug effects KW - Nervous System Diseases -- psychology KW - Nervous System Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77940117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Behavioral+indices+of+neurotoxicity%3A+what+can+be+measured%3F&rft.au=Tilson%2C+H+A&rft.aulast=Tilson&rft.aufirst=H&rft.date=1987-11-01&rft.volume=9&rft.issue=6&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-07 N1 - Date created - 1988-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Co-oxidation of 2-bromohydroquinone by renal prostaglandin synthase. Modulation of prostaglandin synthesis by 2-bromohydroquinone and glutathione. AN - 77939006; 2893705 AB - Homogenates from rat renal papillae, a rich source of the prostaglandin (PG) H synthase system (PHS), metabolized [14C]2-bromohydroquinone, in the presence of arachidonic acid, to products which are covalently bound to protein. The co-oxidation of 2-bromohydroquinone caused a concentration-dependent stimulation in 6-keto-PGF1 alpha, thromboxane B2, PGF2 alpha, PGE2, and PGD2 formation. Glutathione (1 mM) caused a decrease in prostaglandin formation and inhibited the arachidonic acid-supported covalent binding of [14C]2-bromohydroquinone with the concomitant formation of [14C]2-bromohydroquinone-glutathione conjugates, oxidized glutathione, and an increase in the recovery of [14C]2-bromohydroquinone. NADPH also inhibited [14C]2-bromohydroquinone covalent binding, probably by reduction of the semiquinone radical back to the hydroquinone. Indomethacin and aspirin, inhibitors of the cyclooxygenase component of PHS, and propylthiouracil and methimazole, inhibitors of the hydroperoxidase component of PHS, inhibited the arachidonic acid-supported covalent binding of [14C]2-bromohydroquinone by 94%, 52%, 78%, and 79% respectively. These data suggest that 1) renal PHS may play a role in activating the nephrotoxin, 2-bromohydroquinone, and that 2) xenobiotic metabolism and its subsequent effects on glutathione levels can modulate renal prostaglandin synthesis. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Lau, S S AU - Monks, T J AD - Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20892. PY - 1987 SP - 801 EP - 807 VL - 15 IS - 6 SN - 0090-9556, 0090-9556 KW - Hydroquinones KW - 0 KW - Prostaglandins KW - 2-bromohydroquinone KW - 583-69-7 KW - Prostaglandin-Endoperoxide Synthases KW - EC 1.14.99.1 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Animals KW - Microsomes, Liver -- metabolism KW - Prostaglandins -- biosynthesis KW - Chromatography, High Pressure Liquid KW - Oxidation-Reduction KW - Rats KW - Rats, Inbred Strains KW - Seminal Vesicles -- metabolism KW - Kidney Medulla -- metabolism KW - Microsomes -- metabolism KW - In Vitro Techniques KW - Gas Chromatography-Mass Spectrometry KW - Male KW - Hydroquinones -- pharmacology KW - Prostaglandin-Endoperoxide Synthases -- metabolism KW - Kidney -- enzymology KW - Glutathione -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77939006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=Co-oxidation+of+2-bromohydroquinone+by+renal+prostaglandin+synthase.+Modulation+of+prostaglandin+synthesis+by+2-bromohydroquinone+and+glutathione.&rft.au=Lau%2C+S+S%3BMonks%2C+T+J&rft.aulast=Lau&rft.aufirst=S&rft.date=1987-11-01&rft.volume=15&rft.issue=6&rft.spage=801&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-01 N1 - Date created - 1988-04-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A comparison of in vivo and in vitro metabolites of the H1-antagonist N,N-dimethyl-N'-2-pyridyl-N'-(2-thienylmethyl)-1,2-ethanediamine (methapyrilene) in the rat. AN - 77929876; 3433800 AB - 1. The H1-antagonist N,N-dimethyl-N'-2-pyridyl-N'-(2-thienylmethyl)-1,2-ethanediamine (methapyrilene) is carcinogenic in rats. 2. The compound, which is inactive in short-term tests and does not bind to DNA, has been classified as a non-genotoxic carcinogen. 3. Studies have been made in vitro and in vivo in F344 and Sprague-Dawley rats. New metabolites included N-(N',N'-dimethylaminoethyl)-2-aminopyridine and the corresponding N'-oxide, a derivative in which methapyrilene is hydroxylated on the 5-position of the pyridine ring, 2-(N',N'-dimethylamino)-N-2'-pyridylacetamide, N-(2-pyridyl)-N-2"-thienylmethyl)aminoacetaldehyde, and 2-hydroxymethylthiophene. 4. Both strains of rat metabolize methapyrilene to reactive species which may be of importance in the carcinogenic process. JF - Xenobiotica; the fate of foreign compounds in biological systems AU - Singer, S S AU - Lijinsky, W AU - Kratz, L E AU - Castagnoli, N AU - Rose, J E AD - NCI-Frederick Cancer Research Facility, BRI-Basic Research Program, MD 21701. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 1279 EP - 1291 VL - 17 IS - 11 SN - 0049-8254, 0049-8254 KW - Aminopyridines KW - 0 KW - Methapyrilene KW - A01LX40298 KW - Glucuronidase KW - EC 3.2.1.31 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Chromatography, Gas KW - Biotransformation KW - Microsomes, Liver -- metabolism KW - Glucuronidase -- metabolism KW - In Vitro Techniques KW - Male KW - Chromatography, High Pressure Liquid KW - Methapyrilene -- metabolism KW - Aminopyridines -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77929876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.atitle=A+comparison+of+in+vivo+and+in+vitro+metabolites+of+the+H1-antagonist+N%2CN-dimethyl-N%27-2-pyridyl-N%27-%282-thienylmethyl%29-1%2C2-ethanediamine+%28methapyrilene%29+in+the+rat.&rft.au=Singer%2C+S+S%3BLijinsky%2C+W%3BKratz%2C+L+E%3BCastagnoli%2C+N%3BRose%2C+J+E&rft.aulast=Singer&rft.aufirst=S&rft.date=1987-11-01&rft.volume=17&rft.issue=11&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.issn=00498254&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-04 N1 - Date created - 1988-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product. AN - 77923254; 3323889 AB - Microinjection of purified protein kinase C (PKC) into Swiss 3T3 fibroblasts pretreated with the phorbol ester phorbol-12,13-dibutyrate restores the mitogenic response of the cells to phorbol-12,13-dibutyrate (G. Pasti, J.C. Lacal, B.S. Warren, S.A. Aaronson, and P.M. Blumberg, Nature [London] 324:375-377, 1986). Our present studies demonstrate that the mitogenic activity of the H-ras oncogene in H-ras p21-microinjected quiescent cells is markedly reduced under conditions in which PKC is downregulated by chronic phorbol ester treatment. The ability to reconstitute the mitogenic response upon microinjection of both H-ras p21 and PKC implies involvement of functional PKC in the mitogenic activity of the H-ras oncogene product. JF - Molecular and cellular biology AU - Lacal, J C AU - Fleming, T P AU - Warren, B S AU - Blumberg, P M AU - Aaronson, S A AD - Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 4146 EP - 4149 VL - 7 IS - 11 SN - 0270-7306, 0270-7306 KW - Carcinogens KW - 0 KW - Phorbol Esters KW - Proto-Oncogene Proteins KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - Index Medicus KW - Phorbol Esters -- pharmacology KW - Mice, Inbred Strains KW - Carcinogens -- pharmacology KW - Animals KW - Cells, Cultured KW - Mice KW - Genes, ras KW - Protein Kinase C -- physiology KW - Proto-Oncogene Proteins -- physiology KW - DNA Replication KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77923254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Involvement+of+functional+protein+kinase+C+in+the+mitogenic+response+to+the+H-ras+oncogene+product.&rft.au=Lacal%2C+J+C%3BFleming%2C+T+P%3BWarren%2C+B+S%3BBlumberg%2C+P+M%3BAaronson%2C+S+A&rft.aulast=Lacal&rft.aufirst=J&rft.date=1987-11-01&rft.volume=7&rft.issue=11&rft.spage=4146&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-08 N1 - Date created - 1988-03-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cell Physiol. 1982 Jul;112(1):42-50 [6286693] J Cell Physiol. 1984 Feb;118(2):133-42 [6319436] Hum Genet. 1984;66(2-3):132-42 [6370829] Biochem Biophys Res Commun. 1984 May 16;120(3):1053-9 [6233972] Nature. 1984 Aug 9-15;310(5977):508-11 [6611509] Cell. 1984 Aug;38(1):109-17 [6380758] Mol Cell Biol. 1987 May;7(5):1984-8 [3037340] Science. 1986 Jan 24;231(4736):407-10 [3001936] Cell. 1986 Feb 28;44(4):609-17 [3004741] Science. 1986 Jul 18;233(4761):305-12 [3014651] Nature. 1986 Nov 27-Dec 3;324(6095):375-7 [3466038] Science. 1986 Dec 19;234(4783):1519-26 [3024320] Nature. 1987 Jan 22-28;325(6102):359-61 [3027568] Biochem Biophys Res Commun. 1985 Jul 31;130(2):646-53 [2992479] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reaction of cyclodextrins with propylene oxide or with glycidol: analysis of product distribution. AN - 77915500; 3427579 AB - Reaction of cyclomalto-hexaose, -heptaose, or -octaose with propylene oxide in strong aqueous alkali gave products in which distribution of the degrees of substitution was relatively narrow and nearly symmetrical, and increased with the average degree of substitution. When an equimolar mixture of cyclomalto-hexaose, heptaose, or -octaose was used, the average degrees of substitution of all three carbohydrates were close to each other. These findings indicate that the reactivities of the hydroxyl groups of cyclomalto-hexaose, -heptaose, or -octaose, and of all their (2-hydroxypropyl) ethers formed in the reactions, are quite similar. Reaction of cyclomaltoheptaose with glycidol also yielded a product having a narrow distribution of degree of substitution, but which was slightly skewed towards the higher degrees. Thus, as it proceeds, this etherification leads to products having higher reactivity towards the epoxide. JF - Carbohydrate research AU - Pitha, J AU - Szabo, L AU - Fales, H M AD - Macromolecular Chemistry Section, National Institute on Aging/GRC, Baltimore, MD 21224. Y1 - 1987/11/01/ PY - 1987 DA - 1987 Nov 01 SP - 191 EP - 198 VL - 168 IS - 2 SN - 0008-6215, 0008-6215 KW - Cyclodextrins KW - 0 KW - Dextrins KW - Epoxy Compounds KW - Ethers, Cyclic KW - Propanols KW - Starch KW - 9005-25-8 KW - glycidol KW - S54CF1DV9A KW - propylene oxide KW - Y4Y7NYD4BK KW - Index Medicus KW - Mass Spectrometry KW - Structure-Activity Relationship KW - Magnetic Resonance Spectroscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77915500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carbohydrate+research&rft.atitle=Reaction+of+cyclodextrins+with+propylene+oxide+or+with+glycidol%3A+analysis+of+product+distribution.&rft.au=Pitha%2C+J%3BSzabo%2C+L%3BFales%2C+H+M&rft.aulast=Pitha&rft.aufirst=J&rft.date=1987-11-01&rft.volume=168&rft.issue=2&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Carbohydrate+research&rft.issn=00086215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-11 N1 - Date created - 1988-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Specific polypeptide differences in normal versus malignant human breast tissues by two-dimensional electrophoresis. AN - 77887503; 3427226 AB - Postmitochondrial and cytosolic polypeptides were extracted from human breast tumors and non-malignant breast tissue and analyzed using high resolution two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). Approximately 800-1000 postmitochondrial and 600-800 silver stained cytosolic polypeptides were detected over the pH range of 4.8 to 7.5 and molecular weight range of 18-120 kDa. The 2D-PAGE patterns of polypeptides from normal and malignant tissue were very similar, although both qualitative and quantitative polypeptide differences were noted. Six cytosolic polypeptides (pI/molecular weight X 10(-3) 5.20/80 kDa, 5.75/43, 6.25/40, 5.43/35, 5.45/34.5, 5.50/34 and 6.15/24 were expressed only in malignant tissues. One constitutive polypeptide, 7.25/52, was not detected in any of the malignant tissue samples. Quantitatively, marked differences in spot density were noted in polypeptides localized mainly in the molecular weight ranges of 22-40 kDa and pI ranges of 5.65-7.00. A general increase in polypeptide expression was noted in malignant tissues as compared to normal. Twenty-two polypeptides were significantly and consistently increased in tumor samples while only one polypeptide was decreased. One polypeptide, p24 (6.15/24) was expressed in greatest concentrations in tumors which also expressed the greatest estrogen receptor content. Expression of p24 was markedly reduced in normal tissue and malignant tissues expressing low levels of estrogen and progesterone receptors. JF - Breast cancer research and treatment AU - Wirth, P J AU - Egilsson, V AU - Gudnason, V AU - Ingvarsson, S AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 177 EP - 189 VL - 10 IS - 2 SN - 0167-6806, 0167-6806 KW - Biomarkers, Tumor KW - 0 KW - Peptides KW - Receptors, Estrogen KW - Receptors, Progesterone KW - Index Medicus KW - Submitochondrial Particles -- analysis KW - Humans KW - Cytoplasm -- analysis KW - Breast -- analysis KW - Electrophoresis, Polyacrylamide Gel -- methods KW - Receptors, Estrogen -- analysis KW - Female KW - Receptors, Progesterone -- analysis KW - Peptides -- analysis KW - Breast Neoplasms -- analysis KW - Biomarkers, Tumor -- analysis KW - Peptides -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77887503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+and+treatment&rft.atitle=Specific+polypeptide+differences+in+normal+versus+malignant+human+breast+tissues+by+two-dimensional+electrophoresis.&rft.au=Wirth%2C+P+J%3BEgilsson%2C+V%3BGudnason%2C+V%3BIngvarsson%2C+S%3BThorgeirsson%2C+S+S&rft.aulast=Wirth&rft.aufirst=P&rft.date=1987-11-01&rft.volume=10&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+and+treatment&rft.issn=01676806&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-26 N1 - Date created - 1988-02-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The use of biochemical assays in epidemiologic studies of reproduction. AN - 77887319; 3691439 AB - Recent progress in the assay of urinary hormones has opened new opportunities for epidemiologists to study hormones and health outcomes. This is especially true for studies of female reproduction. The cyclic nature of female reproduction can be fully described only by continuous frequent measurements that, in order to be practical, require easily collected biological specimens. We describe our experience in collecting and analyzing daily urine specimens from 301 healthy women. We conclude that this approach is not only feasible but potentially of great value to epidemiologists for studying fertility, early pregnancy, the effects of toxic exposures on reproduction, and the relationships between reproduction and later risk of chronic diseases. JF - Environmental health perspectives AU - Wilcox, A J AU - Baird, D D AU - Weinberg, C R AU - Armstrong, E G AU - Musey, P I AU - Wehmann, R E AU - Canfield, R E AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 29 EP - 35 VL - 75 SN - 0091-6765, 0091-6765 KW - Chorionic Gonadotropin KW - 0 KW - Estrogens KW - Progesterone KW - 4G7DS2Q64Y KW - Luteinizing Hormone KW - 9002-67-9 KW - Index Medicus KW - Fertility KW - Epidemiologic Methods KW - Humans KW - Adult KW - Menstruation KW - Radioimmunoassay KW - Coitus KW - Female KW - Estrogens -- urine KW - Progesterone -- urine KW - Luteinizing Hormone -- urine KW - Chorionic Gonadotropin -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77887319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=The+use+of+biochemical+assays+in+epidemiologic+studies+of+reproduction.&rft.au=Wilcox%2C+A+J%3BBaird%2C+D+D%3BWeinberg%2C+C+R%3BArmstrong%2C+E+G%3BMusey%2C+P+I%3BWehmann%2C+R+E%3BCanfield%2C+R+E&rft.aulast=Wilcox&rft.aufirst=A&rft.date=1987-11-01&rft.volume=75&rft.issue=&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Steroids. 1978 Mar;31(3):407-26 [208199] Fertil Steril. 1987 Feb;47(2):265-9 [3817172] Bull World Health Organ. 1970;43(2):209-21 [5312521] Lancet. 1980 Sep 13;2(8194):554-6 [6106737] Obstet Gynecol. 1981 Jul;58(1):5-9 [7195531] J Clin Invest. 1981 Jul;68(1):184-94 [7251859] Clin Chem. 1981 Dec;27(12):1997-2001 [6171363] Fertil Steril. 1982 Mar;37(3):361-6 [7060787] J Clin Endocrinol Metab. 1982 Oct;55(4):654-9 [7107812] Fertil Steril. 1982 Oct;38(4):447-53 [7117572] Lancet. 1983 May 21;1(8334):1126-7 [6133154] Am J Epidemiol. 1984 Jul;120(1):161-3 [6741916] J Clin Endocrinol Metab. 1984 Nov;59(5):867-74 [6480810] Ann N Y Acad Sci. 1985;442:1-22 [3860032] Am J Reprod Immunol Microbiol. 1985 Jun;8(2):48-54 [2411157] Fertil Steril. 1985 Sep;44(3):366-74 [4029425] J Reprod Med. 1986 Aug;31(8 Suppl):760-3 [3761282] J Clin Endocrinol Metab. 1987 Jan;64(1):111-8 [2946715] N Engl J Med. 1987 Jan 29;316(5):229-34 [3099198] J Steroid Biochem. 1979 Aug;11(2):1165-71 [502558] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mortality among flavour and fragrance chemical plant workers in the United States. AN - 77879222; 3689704 AB - Vital status on 1 January 1981 was determined for a cohort of 1412 white men employed in a flavour and fragrance chemical plant between 1945 and 1965 in order to investigate the risks from fatal diseases among men exposed to multiple chemicals in the manufacture of fragrances, flavours, aroma chemicals, and other organic substances. Cause specific standardised mortality ratios (SMRs) were calculated for the entire study population and for several subsets by likelihood of exposure to chemicals, duration of employment, and year of hire. SMRs for rectal cancer and ischaemic heart disease were raised among white male employees whose jobs were in production, maintenance, laboratory, or other jobs that would involve exposure to multiple chemicals used and produced in the plant. The excess of rectal cancer was confined to employees who had worked as chemical operators and mortality was significantly raised among men who worked for ten or more years. Traces of dioxin were recently found in and around plant buildings that used trichlorophenol in the production of hexachlorophene. The study group was small and had limited power to detect excess risk of rare causes of death; however, no soft tissue sarcomas were observed during the study period. JF - British journal of industrial medicine AU - Thomas, T L AD - Occupational Studies Section, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 733 EP - 737 VL - 44 IS - 11 SN - 0007-1072, 0007-1072 KW - Flavoring Agents KW - 0 KW - Perfume KW - Index Medicus KW - United States KW - Digestive System Neoplasms -- mortality KW - Humans KW - Heart Diseases -- chemically induced KW - Heart Diseases -- mortality KW - Male KW - Digestive System Neoplasms -- chemically induced KW - Perfume -- adverse effects KW - Flavoring Agents -- adverse effects KW - Occupational Diseases -- chemically induced KW - Chemical Industry KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77879222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+industrial+medicine&rft.atitle=Mortality+among+flavour+and+fragrance+chemical+plant+workers+in+the+United+States.&rft.au=Thomas%2C+T+L&rft.aulast=Thomas&rft.aufirst=T&rft.date=1987-11-01&rft.volume=44&rft.issue=11&rft.spage=733&rft.isbn=&rft.btitle=&rft.title=British+journal+of+industrial+medicine&rft.issn=00071072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Comput Biomed Res. 1974 Aug;7(4):325-32 [4850570] Br J Cancer. 1979 Jun;39(6):711-7 [444410] Lancet. 1981 Jan 31;1(8214):268-9 [6109913] J Occup Med. 1981 Jan;23(1):13-21 [7205412] Br J Ind Med. 1985 Apr;42(4):240-5 [3978043] J Occup Med. 1982 Apr;24(4):315-9 [7069524] Am J Ind Med. 1983;4(4):523-32 [6869377] J Occup Med. 1983 Dec;25(12):879-85 [6655522] Arch Environ Health. 1981 May-Jun;36(3):120-9 [6787990] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reductive destruction of dacarbazine, procarbazine hydrochloride, isoniazid, and iproniazid. AN - 77861170; 3687991 AB - Reductive destruction of dacarbazine, procarbazine hydrochloride, isoniazid, and iproniazid using nickel-aluminum alloy in basic solution is described. Solutions of dacarbazine 10 mg/mL were prepared by adding dacarbazine 100 mg, citric acid 100 mg, and mannitol 50 mg to 10 mL of water. Aqueous solutions of procarbazine hydrochloride 10 mg/mL were prepared from commercially available capsules, and aqueous solutions of isoniazid 10 mg/mL and iproniazid 5 mg/mL were prepared from powdered drug. Reductive destruction of drugs was accomplished by mixing each solution with an equal volume of 1 M potassium hydroxide solution and adding 1 g of nickel-aluminum alloy for each 20 mL of basified solution. The resulting mixtures were stirred for 20 hours (96 hours for iproniazid) and analyzed by high-performance liquid chromatography and gas chromatography for the presence of residual drug and degradation products. Dacarbazine solutions were also subjected to destruction by photolysis and by oxidation using potassium permanganate in sulfuric acid, and the results were compared with those obtained by reductive destruction. All reaction mixtures were tested for mutagenicity in Salmonella strains. All drugs subjected to reductive destruction were completely degraded to the limits of detection of the assay and produced only nonmutagenic reaction mixtures. The only acceptable results for dacarbazine were obtained by the reductive destruction method. Reduction of dacarbazine, procarbazine hydrochloride, isoniazid, and iproniazid with nickel-aluminum alloy in dilute base appears to be a good method for the destruction of these toxic compounds. JF - American journal of hospital pharmacy AU - Lunn, G AU - Sansone, E B AD - Environmental Control and Research Program, NCI-Frederick Cancer Research Facility, MD 21701-1013. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 2519 EP - 2524 VL - 44 IS - 11 SN - 0002-9289, 0002-9289 KW - Alloys KW - 0 KW - Waste Products KW - Procarbazine KW - 35S93Y190K KW - Dacarbazine KW - 7GR28W0FJI KW - Nickel KW - 7OV03QG267 KW - Aluminum KW - CPD4NFA903 KW - Iproniazid KW - D892HFI3XA KW - Isoniazid KW - V83O1VOZ8L KW - Index Medicus KW - Oxidation-Reduction KW - Mutagenicity Tests KW - Dacarbazine -- toxicity KW - Iproniazid -- toxicity KW - Procarbazine -- toxicity KW - Isoniazid -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77861170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hospital+pharmacy&rft.atitle=Reductive+destruction+of+dacarbazine%2C+procarbazine+hydrochloride%2C+isoniazid%2C+and+iproniazid.&rft.au=Lunn%2C+G%3BSansone%2C+E+B&rft.aulast=Lunn&rft.aufirst=G&rft.date=1987-11-01&rft.volume=44&rft.issue=11&rft.spage=2519&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hospital+pharmacy&rft.issn=00029289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-21 N1 - Date created - 1988-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative evaluation of genetic toxicity patterns of carcinogens and noncarcinogens: strategies for predictive use of short-term assays. AN - 77858007; 3319571 AB - The results of a recent comprehensive evaluation of the relationship between four measures of in vitro genetic toxicity and the capacity of the chemicals to induce neoplasia in rodents carry some important implications. The results showed that while the Salmonella mutagenesis assay detected only about half of the carcinogens as mutagens, the other three in vitro assays (mutagenesis in MOLY cells or induction of aberrations or SCEs in CHO cells) did not complement Salmonella since they failed to effectively discriminate between the carcinogens and noncarcinogens found negative in the Salmonella assay. The specificity of the Salmonella assay for this group of 73 chemicals was relatively high (only 4 of 29 noncarcinogens were positive). Therefore, we have begun to evaluate in vivo genetic toxicity assays for their ability to complement Salmonella in the identification of carcinogens. JF - Environmental health perspectives AU - Tennant, R W AU - Spalding, J W AU - Stasiewicz, S AU - Caspary, W D AU - Mason, J M AU - Resnick, M A AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 87 EP - 95 VL - 75 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Index Medicus KW - Animals KW - Sex Factors KW - Cell Transformation, Neoplastic -- drug effects KW - Mice KW - Salmonella typhimurium -- drug effects KW - Rats KW - Mutagenicity Tests KW - Sister Chromatid Exchange -- drug effects KW - Chromosome Aberrations KW - Species Specificity KW - Drosophila KW - Drug Evaluation, Preclinical KW - Female KW - Male KW - Cricetinae KW - Neoplasms -- chemically induced KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77858007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Comparative+evaluation+of+genetic+toxicity+patterns+of+carcinogens+and+noncarcinogens%3A+strategies+for+predictive+use+of+short-term+assays.&rft.au=Tennant%2C+R+W%3BSpalding%2C+J+W%3BStasiewicz%2C+S%3BCaspary%2C+W+D%3BMason%2C+J+M%3BResnick%2C+M+A&rft.aulast=Tennant&rft.aufirst=R&rft.date=1987-11-01&rft.volume=75&rft.issue=&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 1980 Jul;1(7):621-5 [11219838] Environ Health Perspect. 1987 Oct;74:229-35 [3691430] Proc Natl Acad Sci U S A. 1975 Dec;72(12):5135-9 [1061098] Nature. 1976 Dec 16;264(5587):624-7 [794741] Cancer Lett. 1976 Sep;2(1):11-5 [189905] Science. 1979 May 11;204(4393):587-93 [373122] Chem Biol Interact. 1980 Mar;29(3):303-14 [7357677] Cancer Res. 1980 Oct;40(10):3616-20 [6108157] J Chem Inf Comput Sci. 1981 Feb;21(1):35-8 [7240352] Science. 1981 Oct 23;214(4519):401-7 [7291981] Environ Health Perspect. 1983 Mar;49:3-12 [6339227] Environ Mutagen. 1983;5 Suppl 1:1-142 [6365529] Environ Mutagen. 1984;6(6):871-8 [6499792] Environ Mutagen. 1985;7(1):87-100 [3917911] Environ Mutagen. 1985;7(5):727-46 [4043025] Environ Mutagen. 1986;8(1):77-98 [3943499] Environ Mutagen. 1986;8(2):205-27 [3698943] Environ Mutagen. 1986;8(4):515-31 [3732194] Food Chem Toxicol. 1986 Jun-Jul;24(6-7):657-61 [3781420] Science. 1987 May 22;236(4804):933-41 [3554512] Proc Natl Acad Sci U S A. 1973 Aug;70(8):2281-5 [4151811] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vitro analysis of multistage carcinogenesis. AN - 77857952; 3319569 AB - Several key events in the multistep process of neoplastic transformation of rat tracheal epithelium (RTE) are described. Whether tracheal epithelium is exposed in vivo to carcinogenic agents or whether primary tracheal epithelial cells are exposed in vitro to carcinogens, initiated stem cells can be detected soon after the exposure by their ability to grow under selective conditions in culture. These initiated stem cells differ fundamentally from normal stem cells in their response to factors normally constraining proliferation and self-renewal. Thus, disruption of inhibitory control mechanisms of stem cell replication appears to be the first event in RTE cell transformation. While the probability of self-renewal (PSR) is clearly increased in initiated stem cells, most of the descendants derived from such stem cells differentiate and become terminal and do not express transformed characteristics. Progression from the first to the second stage of RTE cell transformation, the stage of the immortal growth variant (IGV), is characterized by loss of responsiveness to the growth-restraining effects of retinoic acid. In the third stage of neoplastic transformation, the stage during which neoplastic growth variants (NGV) appear, a growth factor receptor gene is inappropriately expressed in some of the transformants. Thus, it appears that loss of growth-restraining mechanisms may be an early event, and activation of a growth stimulatory mechanism a late event, in neoplastic transformation of RTE cells. JF - Environmental health perspectives AU - Nettesheim, P AU - Fitzgerald, D J AU - Kitamura, H AU - Walker, C L AU - Gilmer, T M AU - Barrett, J C AU - Gray, T E AD - Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 71 EP - 79 VL - 75 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Animals KW - Tretinoin -- metabolism KW - Trachea -- drug effects KW - Carcinogens -- toxicity KW - Cell Transformation, Neoplastic -- drug effects KW - Neoplastic Stem Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77857952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=In+vitro+analysis+of+multistage+carcinogenesis.&rft.au=Nettesheim%2C+P%3BFitzgerald%2C+D+J%3BKitamura%2C+H%3BWalker%2C+C+L%3BGilmer%2C+T+M%3BBarrett%2C+J+C%3BGray%2C+T+E&rft.aulast=Nettesheim&rft.aufirst=P&rft.date=1987-11-01&rft.volume=75&rft.issue=&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lab Invest. 1971 Jan;24(1):55-66 [4322702] Proc Natl Acad Sci U S A. 1987 Apr;84(7):1804-8 [3470760] Can Med Assoc J. 1980 Apr 5;122(7):757-65 [6988069] J Natl Cancer Inst. 1981 Jun;66(6):1037-52 [6941039] Cancer Res. 1982 Nov;42(11):4511-8 [6812948] Carcinogenesis. 1984 May;5(5):671-82 [6327109] Crit Rev Toxicol. 1984;12(3):215-39 [6378528] Cancer Res. 1984 Nov;44(11):4909-18 [6386145] Cancer Res. 1985 Apr;45(4):1437-43 [2983882] Carcinogenesis. 1986 Apr;7(4):669-71 [3698199] Proc Natl Acad Sci U S A. 1986 May;83(10):3331-5 [3010289] Cancer Res. 1986 Sep;46(9):4631-41 [3731116] Cancer Res. 1986 Sep;46(9):4642-9 [3731117] Carcinogenesis. 1986 Oct;7(10):1715-21 [3757173] Cancer Res. 1979 Oct;39(10):4003-10 [113084] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biochemical and molecular epidemiology of human cancer: indicators of carcinogen exposure, DNA damage, and genetic predisposition. AN - 77857900; 3319559 AB - The primary goal of biochemical and molecular epidemiology is to identify individuals at high cancer risk by obtaining evidence of high exposure to carcinogens, leading to pathobiological lesions in target cells, and/or increased oncogenic susceptibility due to either inherited or acquired host factors. This emerging and multidisciplinary area of cancer research combines epidemiological and laboratory approaches. Because DNA is considered to be an important target for modification by mutagens and carcinogens, damage to DNA can be used as an internal, molecular dosimeter of carcinogen exposure. The reactive species of these carcinogens may directly bind to DNA to form adducts and may indirectly cause secondary DNA lesions, e.g., via induction of free radicals and aldehydes. Highly sensitive and specific methods have been developed to measure the minute amounts of DNA lesions and DNA repair products found in biological specimens from humans exposed to carcinogens. For example, DNA adducts have been measured in cells and tissues from people occupationally exposed to carcinogenic polycyclic aromatic hydrocarbons. Antibodies recognizing carcinogen-DNA adducts have also been detected in human sera. Inherited predisposition to cancer has been revealed by recent advances in molecular genetics, including restriction-fragment-length polymorphism. For example, the hypothesis that rare alleles of the Ha-ras proto-oncogene are associated with an increased risk of lung cancer is currently being tested. These approaches afford the potential of biochemical and molecular epidemiology to predict disease risk for individual persons, instead of for populations, and before the onset of clinically evident disease. JF - Environmental health perspectives AU - Harris, C C AU - Weston, A AU - Willey, J C AU - Trivers, G E AU - Mann, D L AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 109 EP - 119 VL - 75 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Humans KW - Environmental Exposure KW - DNA -- analysis KW - Neoplasms -- chemically induced KW - Carcinogens -- poisoning KW - Neoplasms -- genetics KW - Neoplasms -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77857900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Biochemical+and+molecular+epidemiology+of+human+cancer%3A+indicators+of+carcinogen+exposure%2C+DNA+damage%2C+and+genetic+predisposition.&rft.au=Harris%2C+C+C%3BWeston%2C+A%3BWilley%2C+J+C%3BTrivers%2C+G+E%3BMann%2C+D+L&rft.aulast=Harris&rft.aufirst=C&rft.date=1987-11-01&rft.volume=75&rft.issue=&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 1982 Oct 16;2(8303):842-5 [6126711] Biochem Pharmacol. 1982 Jul 15;31(14):2311-7 [6181791] Cancer Res. 1982 Dec;42(12):4875-917 [6814745] Carcinogenesis. 1982;3(12):1405-10 [6295657] Biochem Biophys Res Commun. 1982 Nov 16;109(1):262-8 [6297478] Mutat Res. 1983 Mar;108(1-3):67-79 [6835232] Toxicol Lett. 1982 Dec;14(3-4):213-20 [6820199] Environ Health Perspect. 1983 Apr;50:247-57 [6409604] Mutat Res. 1983 Aug;112(4):191-200 [6888408] Cancer Res. 1983 Nov;43(11):5570-4 [6616484] Carcinogenesis. 1984 Jan;5(1):1-5 [6690079] Environ Mutagen. 1983;5(6):929-40 [6653511] Monogr Pathol. 1985;(26):140-67 [3903477] Carcinogenesis. 1985 Dec;6(12):1721-4 [4064248] Int J Cancer. 1985 Dec 15;36(6):661-5 [4066072] Nature. 1985 Nov 28-Dec 4;318(6044):377-80 [2999610] Science. 1986 Jan 3;231(4733):54-7 [3941892] Environ Health Perspect. 1985 Oct;62:5-18 [4085448] Environ Health Perspect. 1985 Oct;62:57-65 [3910421] Environ Health Perspect. 1985 Oct;62:89-94 [4085451] Cytogenet Cell Genet. 1986;41(2):65-70 [3956263] Carcinogenesis. 1986 Apr;7(4):637-40 [3698196] Annu Rev Med. 1986;37:377-95 [3010808] Carcinogenesis. 1986 Jul;7(7):1115-20 [3719906] Proc Natl Acad Sci U S A. 1986 Jul;83(14):5209-13 [3523486] Cancer Res. 1986 Aug;46(8):4178-83 [3731085] Cancer Res. 1984 Mar;44(3):1231-4 [6420055] Science. 1984 Mar 9;223(4640):1028-33 [6320372] Nature. 1984 May 10-16;309(5964):170-2 [6325936] Nature. 1984 May 10-16;309(5964):172-4 [6325937] Nature. 1984 May 10-16;309(5964):174-6 [6325938] Nature. 1984 May 10-16;309(5964):176-8 [6325939] Nature. 1984 Nov 8-14;312(5990):169-70 [6504125] Cancer Res. 1985 Jan;45(1):66-8 [3965153] Science. 1985 Jan 25;227(4685):375-81 [2981433] Carcinogenesis. 1985 Aug;6(8):1109-15 [3926334] Proc Natl Acad Sci U S A. 1985 Sep;82(18):6216-20 [2994066] Adv Cancer Res. 1985;44:43-68 [3898739] Proc Natl Acad Sci U S A. 1985 Oct;82(19):6492-6 [3931076] Proc Natl Acad Sci U S A. 1985 Oct;82(19):6672-6 [2413443] Prog Exp Tumor Res. 1987;31:76-85 [3550892] J Lab Clin Med. 1964 Mar;63:394-403 [14164493] Nature. 1970 Jul 25;227(5256):403-4 [5428445] Bull Environ Contam Toxicol. 1977 Feb;17(2):196-203 [402965] Cancer Res. 1978 Nov;38(11 Pt 1):3573-83 [359124] Science. 1979 May 11;204(4393):587-93 [373122] Ann N Y Acad Sci. 1979 May 31;320:60-8 [287404] Ann N Y Acad Sci. 1979 May 31;320:69-124 [110205] Environ Health Perspect. 1979 Apr;29:71-9 [510245] Cancer Res. 1980 Feb;40(2):412-6 [7356524] Cancer Res. 1981 Mar;41(3):1091-5 [7459852] Nature. 1981 Jan 29;289(5796):353-7 [6258076] Science. 1981 Feb 27;211(4485):951-2 [7466368] Cancer. 1981 Mar 1;47(5 Suppl):1055-64 [7016297] Carcinogenesis. 1986 Sep;7(9):1519-21 [3742724] J Natl Cancer Inst. 1986 Sep;77(3):697-701 [3462411] Nature. 1986 Aug 14-20;322(6080):644-7 [3092103] Cancer Res. 1986 Oct;46(10):5392-400 [3756889] Cancer Res. 1986 Nov;46(11):5869-77 [3756927] J Cancer Res Clin Oncol. 1986;112(2):85-91 [3095332] Nature. 1986 Oct 16-22;323(6089):643-6 [2877398] Adv Cancer Res. 1986;47:1-36 [3535425] Arch Surg. 1986 Nov;121(11):1259-61 [3778197] Carcinogenesis. 1986 Dec;7(12):2071-5 [3779901] Science. 1986 Dec 19;234(4783):1582-5 [3538420] Cancer Res. 1987 Jan 1;47(1):1-10 [3539318] Nature. 1987 Jan 1-7;325(6099):73-5 [2879249] Carcinogenesis. 1987 Mar;8(3):455-60 [3815740] J Natl Cancer Inst. 1981 Jun;66(6):1037-52 [6941039] J Natl Cancer Inst. 1981 Sep;67(3):515-9 [6944523] Science. 1982 Jan 15;215(4530):252-9 [7053574] J Cancer Res Clin Oncol. 1981;102(2):99-113 [7040411] J Cell Biochem. 1982;18(3):285-94 [7068783] J Chronic Dis. 1982;35(7):581-600 [6282919] J Occup Med. 1982 May;24(5):369-74 [7045298] Proc Natl Acad Sci U S A. 1982 Jun;79(12):3682-6 [6980417] Acta Pharmacol Toxicol (Copenh). 1982 Apr;50(4):251-60 [6285672] Pharmacol Rev. 1982 Jun;34(2):189-222 [6287505] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Radiation risk estimation models. AN - 77857842; 3319558 AB - Cancer risk models and their relationship to ionizing radiation are discussed. There are many model assumptions and risk factors that have a large quantitative impact on the cancer risk estimates. Other health end points such as mental retardation may be an even more serious risk than cancer for those with in utero exposures. JF - Environmental health perspectives AU - Hoel, D G AD - Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 105 EP - 107 VL - 75 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Dose-Response Relationship, Radiation KW - Models, Biological KW - Neoplasms, Radiation-Induced -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77857842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Radiation+risk+estimation+models.&rft.au=Hoel%2C+D+G&rft.aulast=Hoel&rft.aufirst=D&rft.date=1987-11-01&rft.volume=75&rft.issue=&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1980 Sep 12;209(4462):1197-203 [7403879] Exp Neurol. 1985 Feb;87(2):185-97 [3967705] Br J Radiol. 1984 May;57(677):409-14 [6539140] Science. 1981 Sep 11;213(4513):1220-7 [7268429] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of oncogenes in chemical carcinogenesis. AN - 77853760; 3319570 AB - Proto-oncogenes are cellular genes that are expressed during normal growth and developmental processes. Altered versions of normal proto-oncogenes have been implicated in the development of human neoplasia. In this report, we show the detection of activated proto-oncogenes in various spontaneous and chemically induced rodent tumors. The majority of activated proto-oncogenes found in these tumors are members of the ras gene family and have been activated by a point mutation. Characterization of the activating mutation may be useful in determining whether this proto-oncogene was activated by direct interaction of the chemical with the DNA. Comparison of activating lesions in spontaneous versus chemically induced tumors should be helpful in determining whether the chemical acts via a genotoxic or a nongenotoxic mechanism. All of this information may be helpful in the assessment of potential carcinogenic hazards of human exposure to chemicals. JF - Environmental health perspectives AU - Stowers, S J AU - Maronpot, R R AU - Reynolds, S H AU - Anderson, M W AD - Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 81 EP - 86 VL - 75 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Index Medicus KW - Animals KW - Genes, ras -- drug effects KW - Humans KW - Proto-Oncogenes KW - Gene Amplification KW - Oncogenes -- drug effects KW - Neoplasms, Experimental -- etiology KW - Carcinogens -- toxicity KW - Cell Transformation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77853760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=The+role+of+oncogenes+in+chemical+carcinogenesis.&rft.au=Stowers%2C+S+J%3BMaronpot%2C+R+R%3BReynolds%2C+S+H%3BAnderson%2C+M+W&rft.aulast=Stowers&rft.aufirst=S&rft.date=1987-11-01&rft.volume=75&rft.issue=&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1979 Nov;76(11):5714-8 [230490] Cancer Res. 1987 Jun 15;47(12):3212-9 [3581065] Science. 1983 Nov 18;222(4625):771-8 [6356358] Nature. 1983 Dec 15-21;306(5944):658-61 [6318112] Science. 1984 May 25;224(4651):843-8 [6326261] Science. 1984 Jun 8;224(4653):1117-21 [6585957] Science. 1984 Jun 8;224(4653):1121-4 [6719137] Science. 1984 Jul 6;225(4657):72-4 [6587568] Lab Invest. 1984 Sep;51(3):258-67 [6433105] Mol Cell Biol. 1984 Sep;4(9):1695-705 [6092933] Cancer Res. 1984 Dec;44(12 Pt 1):5463-74 [6388826] Nature. 1984 Dec 6-12;312(5994):513-6 [6095109] Annu Rev Genet. 1984;18:553-612 [6397126] Cancer Res. 1985 Apr;45(4):1823-7 [2983887] Science. 1985 May 3;228(4699):596-7 [3983645] Nature. 1985 May 30-Jun 5;315(6018):382-5 [3923365] Cell. 1985 Aug;42(1):23-38 [2990725] Nature. 1985 Nov 7-13;318(6041):69-73 [2997622] Science. 1985 Nov 15;230(4727):770-6 [2997917] Carcinogenesis. 1985 Dec;6(12):1709-12 [4064247] Proc Natl Acad Sci U S A. 1986 Jan;83(1):33-7 [3510430] Nature. 1986 Feb 27-Mar 5;319(6056):743-8 [2869410] Cell. 1986 Jun 6;45(5):649-57 [2871941] Proc Natl Acad Sci U S A. 1986 Jun;83(11):3997-4001 [3459165] Nature. 1986 Jul 3-9;322(6074):78-80 [3014349] Proc Natl Acad Sci U S A. 1986 Jul;83(14):4993-7 [3014525] Cell. 1986 Aug 1;46(3):447-56 [3015415] Proc Natl Acad Sci U S A. 1986 Aug;83(16):6048-52 [3016738] Mol Cell Biol. 1986 Jul;6(7):2716-20 [3785207] Proc Natl Acad Sci U S A. 1986 Dec;83(24):9418-22 [3099282] Science. 1987 Jan 9;235(4785):177-82 [3798106] Mol Cell Biol. 1987 Feb;7(2):932-5 [3547086] Nature. 1983 May 5-11;303(5912):72-4 [6843661] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pulsatile peptide secretion: encoding of brain messages regulating endocrine and reproductive functions. AN - 77853325; 3319562 AB - Neuropeptides are defined chemical messengers produced by the brain to modulate its own activity and also to regulate the function of every organ system. These neuropeptides can be viewed as coded chemical signals produced by the brain and secreted into the blood or into other fluids, such as the cerebrospinal fluid, to be transported and to act at a distant site. The signals arrive to the target organ or sometimes to an intermediary station, such as the pituitary gland, where they are decoded, transformed into a more powerful signal, and sent again through the general circulation to reach their final target. Our work has characterized the episodic or pulsatile pattern of secretion of a number of peptide hormones produced by the brain or the pituitary gland and analyzed the brain mechanisms involved in the generation of such a pulsatile pattern of hormone secretion. Molecular biology approaches have provided information on the synthesis, processing, and secretion of these brain messengers. In addition, using computer-assisted perifusion systems, we have been able to reproduce in vitro some of the signals produced by the brain and are currently trying to decode the message carried by those signals, as well as determining the intracellular messengers involved in the signal process. The importance of the neuropeptides and of the messages carried by the pulsatile signal is underlined by experiments in which animals treated with a neurotoxin were rendered infertile.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Environmental health perspectives AU - Negro-Vilar, A AU - Culler, M D AU - Valença, M M AU - Flack, T B AU - Wisniewski, G AD - Reproductive Neuroendocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 37 EP - 43 VL - 75 SN - 0091-6765, 0091-6765 KW - Neuropeptides KW - 0 KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Luteinizing Hormone KW - 9002-67-9 KW - Index Medicus KW - Rats KW - Luteinizing Hormone -- secretion KW - Animals KW - Pituitary Gland -- secretion KW - Gonadotropin-Releasing Hormone -- secretion KW - Pulsatile Flow KW - Male KW - Neuropeptides -- secretion KW - Brain -- secretion KW - Brain -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77853325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Pulsatile+peptide+secretion%3A+encoding+of+brain+messages+regulating+endocrine+and+reproductive+functions.&rft.au=Negro-Vilar%2C+A%3BCuller%2C+M+D%3BValen%C3%A7a%2C+M+M%3BFlack%2C+T+B%3BWisniewski%2C+G&rft.aulast=Negro-Vilar&rft.aufirst=A&rft.date=1987-11-01&rft.volume=75&rft.issue=&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Endocrinology. 1976 Mar;98(3):562-70 [1261487] Brain Res. 1977 May 20;127(1):137-52 [861747] Endocrinology. 1979 Jul;105(1):86-91 [221208] Recent Prog Horm Res. 1980;36:53-88 [6774388] Adv Exp Med Biol. 1987;219:85-108 [3124526] Mol Cell Endocrinol. 1984 Oct;37(3):311-8 [6209179] Endocrinology. 1986 Feb;118(2):609-12 [3080310] Methods Enzymol. 1986;124:67-79 [3086664] Endocrinology. 1987 May;120(5):2011-21 [2436893] Endocrinology. 1984 Jan;114(1):201-6 [6418523] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ultraviolet carcinogenesis in athymic nude mice. AN - 77850944; 3500533 AB - We have investigated the development of skin cancer from exposure to ultraviolet (UV) radiation in C3H- nu/nu nude mice. Nude mice, nude mice reconstituted with thymuses, and nude mouse skin grafted onto normal haired mice had similar tumor incidences and rates of tumor development. All tumors were squamous cell carcinomas and both well-differentiated and poorly differentiated lesions occurred in each of the groups. Transplants of the tumors that developed in nude skin grew preferentially in immunosuppressed mice as compared with normal mice, indicating that tumors from each treatment group were antigenic. These results indicate that the presence or absence of a functioning thymus does not seem to influence UV carcinogenesis. JF - Transplantation AU - Hoover, T L AU - Morison, W L AU - Kripke, M L AD - Laboratory of Chemical and Physical Carcinogenesis, NCI-Frederick Cancer Research Facility, Maryland 21701. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 693 EP - 695 VL - 44 IS - 5 SN - 0041-1337, 0041-1337 KW - Index Medicus KW - Neoplasm Transplantation KW - Thymus Gland -- immunology KW - Animals KW - Graft Rejection KW - Mice, Inbred C3H KW - Mice, Nude KW - Mice KW - Carcinoma, Squamous Cell -- immunology KW - Carcinoma, Squamous Cell -- etiology KW - Skin Neoplasms -- immunology KW - Skin Neoplasms -- etiology KW - Ultraviolet Rays -- adverse effects KW - T-Lymphocytes -- immunology KW - Neoplasms, Radiation-Induced -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77850944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation&rft.atitle=Ultraviolet+carcinogenesis+in+athymic+nude+mice.&rft.au=Hoover%2C+T+L%3BMorison%2C+W+L%3BKripke%2C+M+L&rft.aulast=Hoover&rft.aufirst=T&rft.date=1987-11-01&rft.volume=44&rft.issue=5&rft.spage=693&rft.isbn=&rft.btitle=&rft.title=Transplantation&rft.issn=00411337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-24 N1 - Date created - 1987-12-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Decreased human birth weights after in utero exposure to PCBs and PCDFs are associated with decreased placental EGF-stimulated receptor autophosphorylation capacity. AN - 77844070; 3119985 AB - Yucheng (oil disease) is a clinical and metabolic syndrome reported in Taiwanese who consumed rice oil contaminated with large amounts of various polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs), including the 2,3,4,7,8- and 1,2,3,4,7,8-PCDF congeners which are similar in structure and toxicity to 2,3,7,8-tetrachlorodibenzo-p-dioxin. A well known characteristic of Yucheng is the marked decrease in birth weights, although the underlying mechanism of this effect is unclear. Placental epidermal growth factor (EGF) receptor binding and autophosphorylation studies were done using tissue samples taken from Yucheng and unexposed control patients. EGF-stimulated receptor autophosphorylation of the human placental EGF receptor in the Yucheng subjects was decreased more than 60% of control levels, 4-5 years after the exposure had occurred. The decrease in EGF receptor phosphorylation was significantly correlated with decrease in birth weights. Nonlinear regression analysis of the 125I-EGF receptor binding data revealed that there were two distinct EGF receptor binding isotherms representing the high affinity-low capacity (HALC) and the low affinity-high capacity (LAHC) binding sites. In contrast to the placental EGF-stimulated phosphorylation data described above, the binding kinetics of the EGF receptor were not significantly altered in the control [HALC site Kd = 0.10 +/- 0.02 (SE) nM, Bmax = 788 +/- 255 fmol/mg of protein; LAHC site Kd = 17.4 +/- 8.2 nM, Bmax = 62 +/- 32 pmol/mg) compared to the Yucheng subjects (HALC site Kd = 0.11 +/- 0.02 nM, Bmax = 784 +/- 305 fmol/mg; LAHC site Kd = 49.5 +/- 24.7 nM, Bmax = 147 +/- 80 pmol/mg). GC-MS analysis of placental specimens showed elevated levels of selected PCB and PCDF congeners in the Yucheng compared to control individuals. Total PCB levels were 0.5 +/- 0.2 ppb and 20.0 +/- 4.8 ppb for the control and Yucheng subjects, respectively. A significant dose-response relationship was observed between the placental EGF receptor phosphorylation levels and the PCB concentrations (total or concentrations of 2,2',4,4',5,5'-hexa- and 2,2'3,3'4,4',5-heptachlorobiphenyls). In contrast, no significant relationship was found between the EGF receptor phosphorylation activity and the 2,3,4,7,8- or 1,2,3,4,7,8-PCDF congeners, which were at nondetectable levels in the control and between 104 and 374 parts per trillion in the Yucheng subjects. In summary, our data reveal that decreased placental EGF receptor phosphorylation capacity is associated with decreased birth weight. Furthermore, PCB tissue concentrations might be a better predictor of effects than are PCDF concentrations. JF - Molecular pharmacology AU - Sunahara, G I AU - Nelson, K G AU - Wong, T K AU - Lucier, G W AD - National Institute of Environmental Health Sciences, Laboratory of Biochemical Risk Analysis, Research Triangle Park, North Carolina 27709. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 572 EP - 578 VL - 32 IS - 5 SN - 0026-895X, 0026-895X KW - Benzofurans KW - 0 KW - Polymers KW - polychlorodibenzofuran KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Reference Values KW - Phosphorylation KW - Kinetics KW - Humans KW - Infant, Newborn KW - Female KW - Pregnancy KW - Receptor, Epidermal Growth Factor -- metabolism KW - Infant, Low Birth Weight KW - Food Contamination KW - Polychlorinated Biphenyls -- poisoning KW - Benzofurans -- poisoning KW - Placenta -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77844070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Decreased+human+birth+weights+after+in+utero+exposure+to+PCBs+and+PCDFs+are+associated+with+decreased+placental+EGF-stimulated+receptor+autophosphorylation+capacity.&rft.au=Sunahara%2C+G+I%3BNelson%2C+K+G%3BWong%2C+T+K%3BLucier%2C+G+W&rft.aulast=Sunahara&rft.aufirst=G&rft.date=1987-11-01&rft.volume=32&rft.issue=5&rft.spage=572&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-06 N1 - Date created - 1988-01-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment of peripheral neuroepithelioma in children and young adults. AN - 77843781; 3316513 AB - Seventeen patients with peripheral neuroepithelioma were treated with an intensive chemotherapy regimen of vincristine, Adriamycin (Adria Laboratories, Columbus, OH), and cyclophosphamide (VADRIAC) in combination with radiation therapy. Fifteen patients with stage III (seven) or stage IV (eight) at presentation were treated on a more intensive regimen including total body irradiation (TBI) (8 Gy). Two patients with stage I (one) or II (one) disease received a less intensive chemotherapy regimen of VADRIAC. Therapy was completed within 6 to 7 months in all patients. The disease arose in the chest wall in 12 patients, pelvis in three patients, and extremity in two patients. Sixteen of the 17 (94%) patients achieved a complete remission. With a median follow-up of 18 months, ten patients remain in complete remission with an actuarial survival of 68% and an actuarial relapse-free survival of 56% at 12 months. On the basis of our initial experience with this tumor, we believe that peripheral neuroepithelioma is a chemoresponsive and radioresponsive tumor. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Miser, J S AU - Kinsella, T J AU - Triche, T J AU - Steis, R AU - Tsokos, M AU - Wesley, R AU - Horvath, K AU - Belasco, J AU - Longo, D L AU - Glatstein, E AD - National Cancer Institute, Bethesda, MD. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 1752 EP - 1758 VL - 5 IS - 11 SN - 0732-183X, 0732-183X KW - Dactinomycin KW - 1CC1JFE158 KW - Vincristine KW - 5J49Q6B70F KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Humans KW - Vincristine -- administration & dosage KW - Prognosis KW - Child KW - Sarcoma, Ewing -- therapy KW - Child, Preschool KW - Whole-Body Irradiation KW - Radiotherapy Dosage KW - Adult KW - Follow-Up Studies KW - Adolescent KW - Time Factors KW - Female KW - Male KW - Dactinomycin -- administration & dosage KW - Extremities KW - Thoracic Neoplasms -- therapy KW - Neuroectodermal Tumors, Primitive, Peripheral -- therapy KW - Thoracic Neoplasms -- drug therapy KW - Thoracic Neoplasms -- radiotherapy KW - Pelvic Neoplasms -- therapy KW - Neuroectodermal Tumors, Primitive, Peripheral -- radiotherapy KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Pelvic Neoplasms -- radiotherapy KW - Pelvic Neoplasms -- drug therapy KW - Neuroectodermal Tumors, Primitive, Peripheral -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77843781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Treatment+of+peripheral+neuroepithelioma+in+children+and+young+adults.&rft.au=Miser%2C+J+S%3BKinsella%2C+T+J%3BTriche%2C+T+J%3BSteis%2C+R%3BTsokos%2C+M%3BWesley%2C+R%3BHorvath%2C+K%3BBelasco%2C+J%3BLongo%2C+D+L%3BGlatstein%2C+E&rft.aulast=Miser&rft.aufirst=J&rft.date=1987-11-01&rft.volume=5&rft.issue=11&rft.spage=1752&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-23 N1 - Date created - 1987-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vivo antitumor activity of tumor-infiltrating lymphocytes expanded in recombinant interleukin-2. AN - 77842630; 3500355 AB - A method was described for the generation of cells from tumor-bearing mice; these cells were capable of exhibiting significant antitumor reactivity when adoptively transferred into tumor-bearing hosts. Tumor cell suspensions from a variety of tumors were able to be separated using enzymatic techniques and they were cultured in medium containing recombinant interleukin-2. Activated infiltrating lymphocytes within these tumors expanded; and, by 6-8 days after initiation of culture, lymphocytes predominated and were able to grow to large numbers. The adoptive transfer of these tumor-infiltrating lymphocytes (TILs) made possible mediation of the reduction of established 3-day pulmonary micrometastases from 5 of 7 tumors tested, including two 3-methylcholanthrene (CAS: 56-49-5)-induced sarcomas, one 1,2-dimethylhydrazine (CAS: 540-73-8)-induced colon carcinoma, and the B16 melanoma, all in C57BL/6 mice, as well as the 1660 bladder carcinoma in BALB/c mice. Approximately 2-4 X 10(6) transferred cells were capable of totally eliminating 3-day established metastases. These cells were thus 50 to 100 times more effective than lymphokine-activated killer cells in reducing established metastases; however, they could not be generated from all tumors. The concomitant administration of recombinant interleukin-2 enhanced, by approximately fivefold, the in vivo activity of these cells. The specificity of action of TILs in vivo was different from that determined by classic amputation rechallenge experiments. The tumor-infiltrating lymphocytes that developed this antitumor reactivity appeared to be Thy-1+ and did not bear the asialo GM1 antigen. The potent antitumor effect of these TILs, when transferred in vivo to tumor-bearing hosts, raises the possibility of utilizing similar approaches for the isolation and therapeutic use of lymphocytes with antitumor reactivity from human tumors. JF - Journal of the National Cancer Institute AU - Spiess, P J AU - Yang, J C AU - Rosenberg, S A AD - Surgery Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 1067 EP - 1075 VL - 79 IS - 5 SN - 0027-8874, 0027-8874 KW - Interleukin-2 KW - 0 KW - Lymphokines KW - Recombinant Proteins KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Animals KW - Lung Neoplasms -- secondary KW - Lymphokines -- pharmacology KW - Immunization, Passive KW - Mice, Inbred C57BL KW - Mice KW - Mice, Inbred BALB C KW - Recombinant Proteins -- therapeutic use KW - Killer Cells, Natural -- immunology KW - Cyclophosphamide -- pharmacology KW - Cytotoxicity, Immunologic KW - Lymphocytes -- immunology KW - Neoplasms, Experimental -- immunology KW - Neoplasms, Experimental -- therapy KW - Interleukin-2 -- therapeutic use KW - Lymphocytes -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77842630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=In+vivo+antitumor+activity+of+tumor-infiltrating+lymphocytes+expanded+in+recombinant+interleukin-2.&rft.au=Spiess%2C+P+J%3BYang%2C+J+C%3BRosenberg%2C+S+A&rft.aulast=Spiess&rft.aufirst=P&rft.date=1987-11-01&rft.volume=79&rft.issue=5&rft.spage=1067&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-18 N1 - Date created - 1987-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Vi capsular polysaccharide-protein conjugates for prevention of typhoid fever. Preparation, characterization, and immunogenicity in laboratory animals. AN - 77840380; 3681191 AB - The Vi has proven to be a protective antigen in two double masked, controlled clinical trials in areas with high rates of typhoid fever (approximately 1% per annum). In both studies the protective efficacy of the Vi was approximately 70%. Approximately 75% of subjects in these areas responded with a fourfold or greater rise of serum Vi antibodies. In contrast, the Vi elicited a fourfold or greater rise in 95-100% of young adults in France and the United States. Methods were devised, therefore, to synthesize Vi-protein conjugates in order to both enhance the antibody response and confer T-dependent properties to the Vi (and theoretically increase its protective action in populations at high risk for typhoid fever). We settled on a method that used the heterobifunctional crosslinking reagent, N-succinimidyl-3-(2-pyridyldithio)-propionate (SPDP), to bind thiol derivatives of the Vi to proteins. This synthetic scheme was reproducible, provided high yields of Vi-protein conjugates, and was applicable to several medically relevant proteins such as diphtheria and tetanus toxoids. The resultant conjugates were more immunogenic in mice and juvenile Rhesus monkeys than the Vi alone. In contrast to the T-independent properties of the Vi, conjugates of this polysaccharide with several medically relevant proteins induced booster responses in mice and in juvenile Rhesus monkeys. Clinical studies with Vi-protein conjugates are planned. This scheme is also applicable to synthesize protein conjugates with other polysaccharides that have carboxyl functions. JF - The Journal of experimental medicine AU - Szu, S C AU - Stone, A L AU - Robbins, J D AU - Schneerson, R AU - Robbins, J B AD - Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, Bethesda, Maryland 20892. Y1 - 1987/11/01/ PY - 1987 DA - 1987 Nov 01 SP - 1510 EP - 1524 VL - 166 IS - 5 SN - 0022-1007, 0022-1007 KW - Antibodies, Bacterial KW - 0 KW - Antigens, Bacterial KW - Diphtheria Toxoid KW - Polysaccharides, Bacterial KW - Proteins KW - Serum Albumin, Bovine KW - Succinimides KW - Tetanus Toxoid KW - Typhoid-Paratyphoid Vaccines KW - capsular polysaccharide, Salmonella KW - N-succinimidyl 3-(2-pyridyldithio)propionate KW - 68181-17-9 KW - Cholera Toxin KW - 9012-63-9 KW - Ethyldimethylaminopropyl Carbodiimide KW - RJ5OZG6I4A KW - Index Medicus KW - Animals KW - Salmonella typhi -- immunology KW - Antigens, Bacterial -- immunology KW - Mice KW - Mice, Inbred BALB C KW - Immunization KW - Citrobacter -- immunology KW - Diphtheria Toxoid -- immunology KW - Antibodies, Bacterial -- analysis KW - Cholera Toxin -- immunology KW - Serum Albumin, Bovine -- immunology KW - Macaca mulatta KW - Female KW - Tetanus Toxoid -- immunology KW - Typhoid Fever -- prevention & control KW - Polysaccharides, Bacterial -- immunology KW - Proteins -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77840380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+experimental+medicine&rft.atitle=Vi+capsular+polysaccharide-protein+conjugates+for+prevention+of+typhoid+fever.+Preparation%2C+characterization%2C+and+immunogenicity+in+laboratory+animals.&rft.au=Szu%2C+S+C%3BStone%2C+A+L%3BRobbins%2C+J+D%3BSchneerson%2C+R%3BRobbins%2C+J+B&rft.aulast=Szu&rft.aufirst=S&rft.date=1987-11-01&rft.volume=166&rft.issue=5&rft.spage=1510&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+experimental+medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-23 N1 - Date created - 1987-12-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prog Immunobiol Stand. 1971;5:485-91 [4633975] Am J Epidemiol. 1965 May;81:350-5 [14294418] J Immunol. 1974 Sep;113(3):729-39 [4370486] Infect Immun. 1976 Feb;13(2):581-9 [1083377] Anal Biochem. 1976 May 7;72:248-54 [942051] J Hyg (Lond). 1977 Oct;79(2):161-80 [269193] Lancet. 1978 Jun 24;1(8078):1328-9 [78096] J Exp Med. 1978 Sep 1;148(3):817-22 [81259] Biochem J. 1978 Sep 1;173(3):723-37 [708370] Immunochemistry. 1978 Nov;15(10-11):839-54 [372096] J Exp Med. 1980 Aug 1;152(2):361-76 [6967514] J Clin Microbiol. 1980 Jul;12(1):22-6 [7419698] Infect Immun. 1981 May;32(2):497-502 [7019072] J Immunol. 1983 Feb;130(2):586-9 [6184399] Infect Immun. 1983 Apr;40(1):245-56 [6601061] Lancet. 1983 Aug 20;2(8347):441-3 [6192305] Infect Immun. 1984 Sep;45(3):582-91 [6332076] J Immunol. 1985 Aug;135(2):930-2 [3925014] Lancet. 1985 Jul 20;2(8447):114-8 [2862316] Rev Infect Dis. 1985 Jul-Aug;7(4):536-46 [2412272] J Biol Stand. 1986 Jan;14(1):25-33 [2420803] J Infect Dis. 1986 Aug;154(2):342-5 [2425009] Rev Infect Dis. 1986 May-Jun;8(3):329-49 [3726393] J Immunol. 1986 Aug 15;137(4):1181-6 [3016088] Carbohydr Res. 1986 Sep 1;152:7-20 [3768916] Infect Immun. 1986 Nov;54(2):448-55 [3095243] Nature. 1965 Aug 7;207(997):614-6 [5883637] Trans Am Clin Climatol Assoc. 1967;78:70-8 [6028241] J Immunol. 1969 Sep;103(3):491-5 [4185041] Acta Sch Med Univ Kioto. 1970 Mar;40(3):284-90 [4194346] J Chromatogr. 1972 Oct 5;72(1):105-11 [5072879] Appl Microbiol. 1972 Oct;24(4):628-33 [4628798] J Infect Dis. 1987 Jan;155(1):155-6 [3794402] J Clin Microbiol. 1987 Mar;25(3):531-5 [3571457] Lancet. 1987 May 9;1(8541):1049-52 [2883393] J Hyg (Lond). 1953 Jun;51(2):260-7 [13069708] Am J Hyg. 1954 Jul;60(1):52-62 [13180501] Arch Biochem Biophys. 1959 May;82(1):70-7 [13650640] Proc Soc Exp Biol Med. 1960 Aug-Sep;104:602-5 [13702951] J Exp Med. 1961 Sep 1;114:327-42 [13702952] J Immunol. 1961 May;86:538-42 [13784897] J Bacteriol. 1974 Sep;119(3):913-22 [4854538] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Accessible and affordable health care for alcoholism and related problems: strategy for cost containment. AN - 77839977; 3682832 AB - Dr. Gordis outlines the health consequences of alcohol consumption and the economic costs of alcohol abuse and alcoholism. He defines alcoholism and discusses alcoholism treatment and the problems inherent in its evaluation and financing. Dr. Gordis stresses the importance of rational alcoholism outcome research in future efforts to contain health care costs. JF - Journal of studies on alcohol AU - Gordis, E AD - National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20857. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 579 EP - 585 VL - 48 IS - 6 SN - 0096-882X, 0096-882X KW - Index Medicus KW - United States KW - Insurance, Health -- economics KW - Humans KW - Forecasting KW - Cost Control -- trends KW - Alcoholism -- rehabilitation KW - Alcoholism -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77839977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Accessible+and+affordable+health+care+for+alcoholism+and+related+problems%3A+strategy+for+cost+containment.&rft.au=Gordis%2C+E&rft.aulast=Gordis&rft.aufirst=E&rft.date=1987-11-01&rft.volume=48&rft.issue=6&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-14 N1 - Date created - 1988-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Augmentation of interleukin-2 immunotherapeutic effects by lymphokine-activated killer cells and allogeneic stimulation in murine tumor cells. AN - 77838565; 3500357 AB - Interleukin-2 (IL-2) and lymphokine-activated killer (LAK) cells were used in intraperitoneal and pulmonary tumor models in C57BL/6 mice. To maintain the immunotherapeutic effects of IL-2 plus LAK treatment but reduce its toxicity, ways were sought to augment IL-2 effects. The investigation showed that the adoptive transfer of LAK cells was a prerequisite for successful therapy of intraperitoneal cancer. When LAK cells were given on consecutive days within one course of immunotherapy, antitumor efficacy was augmented with additional doses of LAK cells. However, with the reduction of 1 complete cycle of IL-2 + LAK cells, no further reduction in intraperitoneal tumor was observed as compared to the reduction after 2 or 4 cycles. LAK cells generated from splenocytes of mice that had received an allogeneic tumor challenge 1 week earlier exerted a highly increased cytotoxicity as compared to normal LAK cells. Furthermore, the potentiation effect of an allogeneic response of the host at the tumor site was demonstrated by decreased numbers of lung implants and improved survival in mice given mixtures of syngeneic and allogeneic tumor cell suspensions. An alloimmune response within the microenvironment of tumor tissue markedly enhanced the antitumor effect of IL-2 against the syngeneic tumor. It was concluded that there is a fundamental need to improve the recruitment of adoptively transferred LAK cells or LAK precursors into tumor tissue. This may be the next step required in the further development of IL-2 and LAK immunotherapy. JF - Journal of the National Cancer Institute AU - Eggermont, A M AU - Steller, E P AU - Ottow, R T AU - Matthews, W AU - Sugarbaker, P H AD - Surgery Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 983 EP - 990 VL - 79 IS - 5 SN - 0027-8874, 0027-8874 KW - Interleukin-2 KW - 0 KW - Lymphokines KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Spleen -- immunology KW - Mice KW - Female KW - Neoplasms, Experimental -- immunology KW - Neoplasms, Experimental -- therapy KW - Interleukin-2 -- therapeutic use KW - Lymphokines -- pharmacology KW - Immunization, Passive KW - Neoplasms, Experimental -- mortality KW - Killer Cells, Natural -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77838565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Augmentation+of+interleukin-2+immunotherapeutic+effects+by+lymphokine-activated+killer+cells+and+allogeneic+stimulation+in+murine+tumor+cells.&rft.au=Eggermont%2C+A+M%3BSteller%2C+E+P%3BOttow%2C+R+T%3BMatthews%2C+W%3BSugarbaker%2C+P+H&rft.aulast=Eggermont&rft.aufirst=A&rft.date=1987-11-01&rft.volume=79&rft.issue=5&rft.spage=983&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-18 N1 - Date created - 1987-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Psychosocial factors in adolescent drinking contexts. AN - 77835660; 3682828 AB - A number of environmental and personality characteristics of adolescent students and their relationship to types of drinking contexts were examined using a series of canonical correlation analyses. The strongest relationship was defined by the perceived normative support for drinking, which accounted for 55% of the variance in the drinking context items for males (58% among females). Positive functions of drinking, personal attitudes and values, and environmental contexts were also associated with drinking context items but accounted for smaller proportions of the variance. The contribution of important environmental, personality and drinking context variables to each canonical relationship is discussed. Consistency of studies relevant to the major finding is reviewed and possible bases for discrepancies are explored. Further studies relating to antecedent networks of access to various drinking contexts are identified as areas deserving more intensive and extensive research efforts. JF - Journal of studies on alcohol AU - Harford, T C AU - Grant, B F AD - Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20857. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 551 EP - 557 VL - 48 IS - 6 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Risk Factors KW - Humans KW - Parent-Child Relations KW - Social Facilitation KW - Attitude KW - Peer Group KW - Adolescent KW - Male KW - Female KW - Social Environment KW - Alcohol Drinking -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77835660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Psychosocial+factors+in+adolescent+drinking+contexts.&rft.au=Harford%2C+T+C%3BGrant%2C+B+F&rft.aulast=Harford&rft.aufirst=T&rft.date=1987-11-01&rft.volume=48&rft.issue=6&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-14 N1 - Date created - 1988-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immediate hypersensitivity. AN - 77830818; 3316320 JF - Journal of the American Academy of Dermatology AU - Keahey, T M AU - Yancey, K B AU - Lawley, T J AD - Allergic Disease Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 826 EP - 837 VL - 17 IS - 5 Pt 1 SN - 0190-9622, 0190-9622 KW - Immunoglobulin E KW - 37341-29-0 KW - Index Medicus KW - Mast Cells -- immunology KW - Insect Bites and Stings -- complications KW - Immunoglobulin E -- immunology KW - Humans KW - Food Hypersensitivity -- physiopathology KW - Urticaria -- etiology KW - Anaphylaxis -- physiopathology KW - Urticaria -- physiopathology KW - Hypersensitivity, Immediate -- immunology KW - Hypersensitivity, Immediate -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77830818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Immediate+hypersensitivity.&rft.au=Keahey%2C+T+M%3BYancey%2C+K+B%3BLawley%2C+T+J&rft.aulast=Keahey&rft.aufirst=T&rft.date=1987-11-01&rft.volume=17&rft.issue=5+Pt+1&rft.spage=826&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-20 N1 - Date created - 1988-01-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Progression of type II cell hypertrophy and hyperplasia during silica-induced pulmonary inflammation. AN - 77818554; 2824924 AB - Type II cell hyperplasia and hypertrophy were quantitated in the lungs of rats exposed to silica by using intratracheal injection. Hypertrophic type II cells were separated from normal type II cells by means of centrifugal elutriation of cells dispersed from the lungs by using protease. Type II cell hypertrophy was also quantitated, in situ, by measuring cell profile areas in lung sections. As a means of distinguishing between the hyperplastic and hypertrophic responses of type II cells we followed the progression of these two responses as a function of time and of dose. Seven, 14, and 28 days after a single intratracheal injection of silica (10 mg/rat), hypertrophic type II cells accounted for 33, 35, and 57% of the total type II cells recovered from the lungs. In contrast, hypertrophic type II cells accounted for less than 15% of the type II cells from control lungs. The appearance of hypertrophic type II cells was dose-related when examined 2 weeks after dosing; however, after only 1 week, the response of the type II cell appeared independent of dose. The hypertrophic response of type II cells could not be separated from the hyperplastic response according to either dose or time responses. These data support the hypothesis that in the lungs of silica-treated rats, the hypertrophic type II cell may be the proliferative type II cell. In addition, the hypertrophic type II cell appears to underlie the marked increases in surfactant levels seen in silica-treated lungs. JF - Laboratory investigation; a journal of technical methods and pathology AU - Miller, B E AU - Dethloff, L A AU - Gladen, B C AU - Hook, G E AD - Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 546 EP - 554 VL - 57 IS - 5 SN - 0023-6837, 0023-6837 KW - Silicon Dioxide KW - 7631-86-9 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Peptide Hydrolases KW - EC 3.4.- KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Hypertrophy KW - Hyperplasia KW - Alkaline Phosphatase -- analysis KW - Peptide Hydrolases -- metabolism KW - Male KW - Pneumonia -- chemically induced KW - Pneumonia -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77818554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Progression+of+type+II+cell+hypertrophy+and+hyperplasia+during+silica-induced+pulmonary+inflammation.&rft.au=Miller%2C+B+E%3BDethloff%2C+L+A%3BGladen%2C+B+C%3BHook%2C+G+E&rft.aulast=Miller&rft.aufirst=B&rft.date=1987-11-01&rft.volume=57&rft.issue=5&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=00236837&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-14 N1 - Date created - 1988-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - History, preliminary results, complications, and future prospects of intraoperative radiotherapy. AN - 77813900; 3119944 AB - Intraoperative electron beam radiotherapy (IORT) is a new combined modality therapy in the treatment of cancer. IORT is delivered during a surgical procedure to a tumor or tumor bed and areas of possible local regional spread, with the ability to shield or physically move normal tissues and organs out of the treatment volume. IORT is feasible for various intraabdominal, retroperitoneal, pelvic, and other malignancies. It is possible to increase the total radiation dose, thereby improving the therapeutic ratio; a better local control without an increasing morbidity. Although the optimum use of IORT is still unknown, it is believed that its greatest value is in combination with maximal surgical resection of the tumor with or without external beam radiotherapy (EBRT). IORT is still an experimental treatment modality combining surgery, EBRT, and if necessary, chemotherapy. Because IORT is an expensive treatment method, it is important to determine which method is the best and most convenient for the patient. The answer can be given only when prospective, randomized clinical IORT trials and cost-effectiveness studies are initiated. JF - Journal of surgical oncology AU - Hoekstra, H J AU - Sindelar, W F AU - Kinsella, T J AU - Oldhoff, J AD - Surgery Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 175 EP - 182 VL - 36 IS - 3 SN - 0022-4790, 0022-4790 KW - Index Medicus KW - History of medicine KW - Radiotherapy, High-Energy -- history KW - Radiotherapy, High-Energy -- adverse effects KW - History, 20th Century KW - Electrons KW - Combined Modality Therapy KW - Radiotherapy, High-Energy -- trends KW - Radiotherapy Dosage KW - Humans KW - Radiotherapy, High-Energy -- methods KW - Radiotherapy -- trends KW - Radiotherapy -- methods KW - Intraoperative Care -- methods KW - Radiotherapy -- history KW - Radiotherapy -- adverse effects KW - Intraoperative Care -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77813900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+surgical+oncology&rft.atitle=History%2C+preliminary+results%2C+complications%2C+and+future+prospects+of+intraoperative+radiotherapy.&rft.au=Hoekstra%2C+H+J%3BSindelar%2C+W+F%3BKinsella%2C+T+J%3BOldhoff%2C+J&rft.aulast=Hoekstra&rft.aufirst=H&rft.date=1987-11-01&rft.volume=36&rft.issue=3&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Journal+of+surgical+oncology&rft.issn=00224790&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-28 N1 - Date created - 1987-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Species correlation in long-term carcinogenicity studies. AN - 81108870; 3677049 AB - Species correlation in neoplastic response was examined for 266 long-term toxicology and carcinogenicity studies. The overall concordance between rats and mice exposed to the same chemical was 74% (198/266). Within a species, the results for males and females were also highly correlated (87% concordance for rats and 89% for mice). Had only male rats and female mice been utilized in these experiments, the same conclusions regarding carcinogenicity would have been reached in 96% of the studies (255/266). The high interspecies correlation shown in these studies supports the view that extrapolation of carcinogenicity outcomes to other species, including humans, is appropriate. JF - Cancer letters AU - Haseman, J K AU - Huff, J E AD - National Institute of Environmental Health Sciences, Research Triangle Park, N.C. 27709. Y1 - 1987/10/30/ PY - 1987 DA - 1987 Oct 30 SP - 125 EP - 132 VL - 37 IS - 2 SN - 0304-3835, 0304-3835 KW - Index Medicus KW - Rats KW - Animals KW - Sex Factors KW - Mice KW - Species Specificity KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81108870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Species+correlation+in+long-term+carcinogenicity+studies.&rft.au=Haseman%2C+J+K%3BHuff%2C+J+E&rft.aulast=Haseman&rft.aufirst=J&rft.date=1987-10-30&rft.volume=37&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-04 N1 - Date created - 1988-01-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Cancer Lett 1988 Jan;38(3):365 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Kainic acid as a tool to study the regulation and function of opioid peptides in the hippocampus. AN - 81093339; 2890224 AB - Kainic acid (KA), an excitatory neurotoxin, was used as a tool to study the metabolism of hippocampal opioid peptides and their functional role in the expression of wet-dog shakes (WDS). A single intracerebral injection of KA (1 microgram/rat) caused recurrent motor seizures lasting 3-6 h. During the convulsive period, native Met5-enkephalin-like (ME-LI) and dynorphin A(1-8)-like (DYN-LI) immunoreactivities in hippocampus decreased by 31 and 63%, respectively. By 24 h after dosing, the hippocampal opioid peptides had returned to control levels, and by 48 h ME-LI had increased 270% and DYN-LI 150%. Immunocytochemical analysis revealed that ME-LI and Leu5-enkephalin-like (LE-LI) immunostaining in the mossy fibers of dentate granule cells and the perforant-temporoammonic pathway had decreased visibly by 6 h and had increased markedly by 48 h following KA. A visible decrease in DYN-LI in mossy fiber axons within 6 h was followed by a substantial increase at 48 h. To determine whether the increases in hippocampal ME-LI reflected changes in ME biosynthesis, levels of mRNA coding for preproenkephalin (mRNAenk) and cryptic ME-LI cleaved by enzyme digestion from preproenkephalin were measured. Following the convulsive period (6 h), mRNAenk was 400% of control, and by 24 h, cryptic ME-LI was 300% of control. Increases in native and cryptic ME-LI and in mRNAenk were also noted in entorhinal cortex, but not in hypothalamus or uninjected striatum. Our data suggest that KA-induced seizures cause an increase in ME release, followed by a compensatory increase in ME biosynthesis in the hippocampus and entorhinal cortex. Several lines of evidence from this study have suggested that hippocampal enkephalins are intimately related to KA-elicited WDS. The shaking behavior was attenuated by pretreatment with naloxone or antisera against [Met5]-enkephalin. We also observed that KA-induced WDS can be mimicked by intrahippocampal injection of enkephalin-related peptides. Furthermore, this study demonstrated that intact dentate granule cells are essential for KA- and enkephalin-induced WDS, since a colchicine injection into the ventral hippocampus, which selectively destroys granule cells, abolished this behavior. JF - Toxicology AU - Hong, J S AU - Grimes, L AU - Kanamatsu, T AU - McGinty, J F AD - Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/10/30/ PY - 1987 DA - 1987 Oct 30 SP - 141 EP - 157 VL - 46 IS - 2 SN - 0300-483X, 0300-483X KW - Endorphins KW - 0 KW - Peptide Fragments KW - enkephalin-Met, like substances KW - Enkephalin, Methionine KW - 58569-55-4 KW - Dynorphins KW - 74913-18-1 KW - dynorphin (1-8) KW - 75790-53-3 KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Seizures -- chemically induced KW - Rats KW - Peptide Fragments -- metabolism KW - Animals KW - Enkephalin, Methionine -- analogs & derivatives KW - Enkephalin, Methionine -- metabolism KW - Dynorphins -- metabolism KW - Endorphins -- metabolism KW - Hippocampus -- metabolism KW - Kainic Acid -- toxicity KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81093339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Kainic+acid+as+a+tool+to+study+the+regulation+and+function+of+opioid+peptides+in+the+hippocampus.&rft.au=Hong%2C+J+S%3BGrimes%2C+L%3BKanamatsu%2C+T%3BMcGinty%2C+J+F&rft.aulast=Hong&rft.aufirst=J&rft.date=1987-10-30&rft.volume=46&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-02 N1 - Date created - 1987-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Colchicine as an investigative tool in neurobiology. AN - 81088532; 3672529 AB - Neurotoxicants are being used with increasing frequency in neurobiology as investigative tools to study the structure and function of the nervous system. Colchicine administered directly into the hippocampus produces preferential destruction of dentate gyrus granule cells and mossy fibers and affects conditioned behavior. Studies from our laboratory have demonstrated the dose- and time-dependent loss of dentate gyrus granule cells and stimulation of motor activity following intradentate administration of colchicine. Preferential degeneration of pyramidal cells and other morphological changes observable at the light microscopic level were not seen in colchicine-treated rats. Other studies showed that intradentate colchicine produces specific damage to granule cells in both the dorsal and ventral hippocampus and that this damage is associated with depletion of dynorphin, a neuropeptide preferentially localized in the granule cells and mossy fibers of the hippocampus. Finally, it was noted that there are compensatory changes in the nervous system following treatment with colchicine and that the behavioral effects of colchicine can be modified by factors such as handling. One potentially important compensatory change occurring after intradentate colchicine is an alteration in cholinergic function. Pharmacological studies suggest that colchicine-treated rats may be less sensitive to the behavioral effects of scopolamine. These experiments support the conclusion that given at the appropriate dose into the hippocampus, colchicine may be a useful investigative tool to study the function of the dentate gyrus granule cells and mossy fibers, as well as the compensatory changes in the nervous system that follow chemical-induced neurodegeneration. JF - Toxicology AU - Tilson, H A AU - Peterson, N J AD - Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/10/30/ PY - 1987 DA - 1987 Oct 30 SP - 159 EP - 173 VL - 46 IS - 2 SN - 0300-483X, 0300-483X KW - Colchicine KW - SML2Y3J35T KW - Index Medicus KW - Rats KW - Behavior, Animal -- drug effects KW - Animals KW - Rats, Inbred F344 KW - Pyramidal Tracts -- drug effects KW - Motor Activity -- drug effects KW - Male KW - Colchicine -- toxicity KW - Hippocampus -- physiology KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81088532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Colchicine+as+an+investigative+tool+in+neurobiology.&rft.au=Tilson%2C+H+A%3BPeterson%2C+N+J&rft.aulast=Tilson&rft.aufirst=H&rft.date=1987-10-30&rft.volume=46&rft.issue=2&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-02 N1 - Date created - 1987-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protein kinase C mediates endotoxin and zymosan-induced prostaglandin synthesis. AN - 77917747; 3123256 AB - Addition of the protein kinase C activators phorbol-12-myristate-13-acetate or 1-oleoyl-2-acetylglycerol, or endotoxin (lipopolysaccharide) or zymosan, to RAW264.7 murine macrophages markedly stimulated prostaglandin E2 synthesis. The protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) blocked prostaglandin E2 synthesis in response to all these agonists. The present results suggest that activation of protein kinase C is a step in the stimulation of arachidonic acid metabolism by agonists in macrophages. JF - European journal of pharmacology AU - Burch, R M AD - Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892. Y1 - 1987/10/27/ PY - 1987 DA - 1987 Oct 27 SP - 431 EP - 435 VL - 142 IS - 3 SN - 0014-2999, 0014-2999 KW - Arachidonic Acids KW - 0 KW - Endotoxins KW - Prostaglandins KW - Prostaglandins E KW - Arachidonic Acid KW - 27YG812J1I KW - Zymosan KW - 9010-72-4 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Prostaglandins E -- biosynthesis KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Wall -- metabolism KW - Mice KW - Cell Wall -- drug effects KW - Leukemia, Experimental -- metabolism KW - Arachidonic Acids -- metabolism KW - Protein Kinase C -- antagonists & inhibitors KW - Zymosan -- pharmacology KW - Prostaglandins -- biosynthesis KW - Protein Kinase C -- physiology KW - Endotoxins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77917747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Protein+kinase+C+mediates+endotoxin+and+zymosan-induced+prostaglandin+synthesis.&rft.au=Burch%2C+R+M&rft.aulast=Burch&rft.aufirst=R&rft.date=1987-10-27&rft.volume=142&rft.issue=3&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-07 N1 - Date created - 1988-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Photooxidation products of primaquine. Structure, antimalarial activity and hemolytic effects. AN - 81074154; 3666145 AB - Photooxidation of primaquine (1) and 5-hydroxyprimaquine (5) afforded a blue dye for which o-quinone structure 4 was elaborated. Similar oxidation of N-ethoxyacetylprimaquine (10) afforded o-quinone 11. Tissue schizontocidal activity of 4 and 11, and bisquinolylmethine 3 prepared earlier, showed that none of them had noteworthy antimalarial activity, but all three produced methemoglobin. JF - FEBS letters AU - Brossi, A AU - Gessner, W AU - Hufford, C D AU - Baker, J K AU - Homo, F AU - Millet, P AU - Landau, I AD - Medicinal Chemistry Section, NIDDK, Bethesda, MD 20892. Y1 - 1987/10/19/ PY - 1987 DA - 1987 Oct 19 SP - 77 EP - 81 VL - 223 IS - 1 SN - 0014-5793, 0014-5793 KW - Methemoglobin KW - 9008-37-1 KW - Primaquine KW - MVR3634GX1 KW - Index Medicus KW - Oxidation-Reduction KW - Plasmodium -- drug effects KW - Animals KW - Cell Survival -- drug effects KW - Liver -- drug effects KW - Biotransformation KW - Hemolysis KW - Structure-Activity Relationship KW - Primaquine -- analogs & derivatives KW - Primaquine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81074154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Photooxidation+products+of+primaquine.+Structure%2C+antimalarial+activity+and+hemolytic+effects.&rft.au=Brossi%2C+A%3BGessner%2C+W%3BHufford%2C+C+D%3BBaker%2C+J+K%3BHomo%2C+F%3BMillet%2C+P%3BLandau%2C+I&rft.aulast=Brossi&rft.aufirst=A&rft.date=1987-10-19&rft.volume=223&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-24 N1 - Date created - 1987-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Site-selective cyclic AMP analogs provide a new approach in the control of cancer cell growth. AN - 81069552; 2822483 AB - Site-selective cyclic AMP analogs bind to site 1 or site 2 of the known cAMP-binding sites depending on the position of substituents on the purine ring, either at C-2 and C-8 (site 1) or at C-6 (site 2). The growth inhibitory effect of such site-selective cAMP analogs used in this investigation with 15 human cancer cell lines surpassed that of analogs previously tested. The most potent analogs were 8-chloro, N6-benzyl and N6-phenyl-8-p-chlorophenylthio-cAMP. The combination of a C-8 with an N6 analog had synergistic effects. The 24 site-selective analogs tested produced growth inhibition ranging from 30 to 80% at micromolar concentrations with no sign of toxic effects. Growth inhibition was not due to a block in a specific phase of the cell cycle but paralleled a change in cell morphology, an increase of the RII cAMP receptor protein and a decrease of p21 ras protein. Since the adenosine counterpart of the 8-chloro analog produced G1 synchronization without affecting the RII and p21 ras protein levels, it is unlikely that an adenosine metabolite is involved in the analog effect. Site-selective cAMP analogs thus provide a new biological tool for control of cancer growth. JF - FEBS letters AU - Katsaros, D AU - Tortora, G AU - Tagliaferri, P AU - Clair, T AU - Ally, S AU - Neckers, L AU - Robins, R K AU - Cho-Chung, Y S AD - Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/10/19/ PY - 1987 DA - 1987 Oct 19 SP - 97 EP - 103 VL - 223 IS - 1 SN - 0014-5793, 0014-5793 KW - Bucladesine KW - 63X7MBT2LQ KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Humans KW - Cell Division -- drug effects KW - Tumor Cells, Cultured -- pathology KW - Breast Neoplasms KW - Drug Synergism KW - Bucladesine -- pharmacology KW - Colonic Neoplasms KW - Structure-Activity Relationship KW - Cyclic AMP -- pharmacology KW - Cyclic AMP -- analogs & derivatives KW - Cell Cycle -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81069552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Site-selective+cyclic+AMP+analogs+provide+a+new+approach+in+the+control+of+cancer+cell+growth.&rft.au=Katsaros%2C+D%3BTortora%2C+G%3BTagliaferri%2C+P%3BClair%2C+T%3BAlly%2C+S%3BNeckers%2C+L%3BRobins%2C+R+K%3BCho-Chung%2C+Y+S&rft.aulast=Katsaros&rft.aufirst=D&rft.date=1987-10-19&rft.volume=223&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-24 N1 - Date created - 1987-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Methylxanthines and breast cancer. AN - 81071660; 3117709 AB - We investigated the relationship between methylxanthine consumption and breast cancer using data from a case-control study which included 1,510 cases and 1,882 controls identified through a nation-wide breast cancer screening program. There was no evidence of a positive association between methylxanthine consumption and risk of breast cancer. In fact, there was some suggestion of a negative association, particularly in women diagnosed after age 50. In addition, there was no evidence of increased risk with past or recent methylxanthine consumption, or with the consumption of caffeine or specific beverages, most notably brewed or instant caffeinated coffee and tea. JF - International journal of cancer AU - Schairer, C AU - Brinton, L A AU - Hoover, R N AD - Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/10/15/ PY - 1987 DA - 1987 Oct 15 SP - 469 EP - 473 VL - 40 IS - 4 SN - 0020-7136, 0020-7136 KW - Tea KW - 0 KW - Xanthines KW - Caffeine KW - 3G6A5W338E KW - Index Medicus KW - Age Factors KW - Beverages KW - Diagnosis-Related Groups KW - Epidemiologic Methods KW - Risk Factors KW - Humans KW - Adult KW - Tea -- adverse effects KW - Caffeine -- adverse effects KW - Middle Aged KW - Cacao -- adverse effects KW - Female KW - Xanthines -- adverse effects KW - Breast Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81071660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Methylxanthines+and+breast+cancer.&rft.au=Schairer%2C+C%3BBrinton%2C+L+A%3BHoover%2C+R+N&rft.aulast=Schairer&rft.aufirst=C&rft.date=1987-10-15&rft.volume=40&rft.issue=4&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-25 N1 - Date created - 1987-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Trimetrexate for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. AN - 81034196; 2958710 AB - Preclinical studies have demonstrated that trimetrexate is a potent inhibitor of dihydrofolate reductase from Pneumocystis carinii. On the basis of this evidence, this lipid-soluble antifolate was used as an antipneumocystis agent in 49 patients with the acquired immunodeficiency syndrome (AIDS) and pneumocystis pneumonia. Simultaneous treatment with the reduced folate leucovorin was used as a specific antidote to protect host tissues from the toxic effects of the antifolate without affecting the antipneumocystis action of trimetrexate. Patients were assigned to three groups and treated for 21 days: in Group I, trimetrexate with leucovorin was used as salvage therapy in patients in whom standard treatments (both pentamidine isethionate and trimethoprim-sulfamethoxazole) could not be tolerated or had failed (16 patients); in Group II, trimetrexate with leucovorin was used as initial therapy in patients with a history of sulfonamide inefficacy or intolerance (16 patients); and in Group III, trimetrexate with leucovorin plus sulfadiazine was used as initial therapy (17 patients). The response and survival rates were, respectively, 69 percent and 69 percent in Group I; 63 percent and 88 percent in Group II; and 71 percent and 77 percent in Group III. Trimetrexate therapy had minimal toxicity; transient neutropenia or thrombocytopenia occurred in 12 patients and mild elevation of serum aminotransferases in 4. We conclude that the combination of trimetrexate and leucovorin is safe and effective for the initial treatment of pneumocystis pneumonia in patients with AIDS and for the treatment of patients with intolerance or lack of response to standard therapies. JF - The New England journal of medicine AU - Allegra, C J AU - Chabner, B A AU - Tuazon, C U AU - Ogata-Arakaki, D AU - Baird, B AU - Drake, J C AU - Simmons, J T AU - Lack, E E AU - Shelhamer, J H AU - Balis, F AD - National Cancer Institute, Clinical Center, Bethesda, MD 20892. Y1 - 1987/10/15/ PY - 1987 DA - 1987 Oct 15 SP - 978 EP - 985 VL - 317 IS - 16 SN - 0028-4793, 0028-4793 KW - Folic Acid Antagonists KW - 0 KW - Quinazolines KW - Sulfadiazine KW - 0N7609K889 KW - Leucovorin KW - Q573I9DVLP KW - Trimetrexate KW - UPN4ITI8T4 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Drug Therapy, Combination KW - Drug Evaluation KW - Sulfadiazine -- administration & dosage KW - Leucovorin -- administration & dosage KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Quinazolines -- pharmacokinetics KW - Quinazolines -- administration & dosage KW - Folic Acid Antagonists -- therapeutic use KW - Acquired Immunodeficiency Syndrome -- complications KW - Pneumonia, Pneumocystis -- drug therapy KW - Folic Acid Antagonists -- administration & dosage KW - Quinazolines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81034196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Trimetrexate+for+the+treatment+of+Pneumocystis+carinii+pneumonia+in+patients+with+the+acquired+immunodeficiency+syndrome.&rft.au=Allegra%2C+C+J%3BChabner%2C+B+A%3BTuazon%2C+C+U%3BOgata-Arakaki%2C+D%3BBaird%2C+B%3BDrake%2C+J+C%3BSimmons%2C+J+T%3BLack%2C+E+E%3BShelhamer%2C+J+H%3BBalis%2C+F&rft.aulast=Allegra&rft.aufirst=C&rft.date=1987-10-15&rft.volume=317&rft.issue=16&rft.spage=978&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-10 N1 - Date created - 1987-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Multidrug resistance in ovarian cancer. AN - 81011592; 3308067 AB - The development of acquired resistance has limited the effectiveness of chemotherapy in the treatment of ovarian cancer. Experimental model systems were developed to study the mechanisms associated with primary resistance to chemotherapeutic agents and broad cross-resistance (multidrug resistance) which is characteristic of human ovarian cancer. Doxorubicin-resistant cell lines developed in vitro by exposure of a sensitive cell line to increasing concentrations of doxorubicin develop resistance on the basis of a decrease in drug accumulation and have increased expression of the mdr-1 gene. This gene encodes for a membrane glycoprotein and leads to a decreased drug accumulation in drug resistant cell lines. Cell lines established from patients refractory to doxorubicin-containing combinations, however, do not demonstrate a decrease in drug accumulation. Studies are in progress on the measurement of mdr-1 levels in tumors of patients undergoing treatment to determine whether agents, such as verapamil may be useful in the treatment of drug resistant gynecologic cancers. Human ovarian cancer cell lines from drug resistant patients also has been demonstrated to increase levels of glutathione. Lowering of glutathione levels with buthionine sulfoximine (BSO), which irreversibly inhibits the enzyme gamma-glutamyl cysteine synthetase, leads to a marked potentiation of the cytotoxicity of melphalan both in vitro and in vivo in a nude mouse model of human ovarian cancer. Based on those studies, BSO is undergoing toxicologic evaluation before initiation of clinical trials in drug resistant patients. Our studies demonstrate that drug resistance in human ovarian cancer is likely due to interaction of multiple factors. However, biochemical intervention in some of the key steps leading to drug resistance has been demonstrated experimentally feasible and indicates that pharmacologic reversal of drug resistance is a clinical possibility. JF - Cancer AU - Fojo, A AU - Hamilton, T C AU - Young, R C AU - Ozols, R F AD - Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/10/15/ PY - 1987 DA - 1987 Oct 15 SP - 2075 EP - 2080 VL - 60 IS - 8 Suppl SN - 0008-543X, 0008-543X KW - Doxorubicin KW - 80168379AG KW - Verapamil KW - CJ0O37KU29 KW - Glutathione KW - GAN16C9B8O KW - Abridged Index Medicus KW - Index Medicus KW - Drug Resistance -- genetics KW - DNA Repair KW - Doxorubicin -- pharmacology KW - Humans KW - Glutathione -- analysis KW - Verapamil -- pharmacology KW - Female KW - Gene Amplification KW - Ovarian Neoplasms -- genetics KW - Ovarian Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81011592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Multidrug+resistance+in+ovarian+cancer.&rft.au=Fojo%2C+A%3BHamilton%2C+T+C%3BYoung%2C+R+C%3BOzols%2C+R+F&rft.aulast=Fojo&rft.aufirst=A&rft.date=1987-10-15&rft.volume=60&rft.issue=8+Suppl&rft.spage=2075&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-13 N1 - Date created - 1987-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biologic therapy for the treatment of malignant common epithelial tumors of the ovary. AN - 81011329; 2443236 AB - There are a number of strategies to the treatment of gynecologic tumors that involve the use of biologic agents. Biologic agents may be immunologic in nature and act directly on the tumor or to boost an immune response to the tumor, or they may be nonimmune in nature and directly affect the tumor or a physiologic process on which the tumor depends. Although the potential for these agents in the treatment of all gynecologic tumors is great, most of the data to date have been generated in ovarian cancer. Clinical trials of alpha interferon administered intraperitoneally in patients with small volume ovarian cancer have revealed high response rates with acceptable toxicity. The mechanism of the antitumor effect (i.e., direct tumor killing vs. indirect boosting host immune response) has not yet been determined. Clinical trials of intraperitoneal lymphokine-activated killer (LAK) cells plus recombinant interleukin-2 have also been started based upon significant antitumor effects noted in xenogeneic systems. The finding that the peritoneal fluid of interferon-treated patients is rich with monocytes and macrophages has led to the development of a clinical trial using intraperitoneal human monocytes activated with recombinant gamma interferon along with gamma interferon. Monoclonal antibodies have already made a significant impact on the diagnosis of ovarian cancer, and are being brought to clinical trial as therapeutic agents. The OC-125 antigen is shed by ovarian tumor cells and its elevation in the serum of patients with undiagnosed pelvic masses is highly predictive for ovarian neoplasia. Furthermore, its persistence in the serum of patients with ovarian cancer during chemotherapy is nearly always associated with persistent disease. A number of monoclonal antibodies specific for ovarian cancer have been developed. Radiolabeled antibodies administered intralymphatically and intraperitoneally may be able to demonstrate the presence of tumor reliably enough to save some patients from second-look laparotomy. In addition, clinical trials are underway using immunotoxins, antitumor antibodies conjugated to potent plant or bacterial toxins that are effective at killing cells with amazing efficiency. Antibodies conjugated to alpha-emitting radioisotopes like astatine-211 or to radioisotopes emitting gamma or beta waves or Auger electrons are candidates for clinical trial. There is also some interest in attempting to improve the therapeutic index by using antibodies conjugated to cytotoxic chemotherapeutic agents.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Cancer AU - Hamilton, T C AU - Ozols, R F AU - Longo, D L AD - Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland. Y1 - 1987/10/15/ PY - 1987 DA - 1987 Oct 15 SP - 2054 EP - 2063 VL - 60 IS - 8 Suppl SN - 0008-543X, 0008-543X KW - Antibodies, Monoclonal KW - 0 KW - Immunotoxins KW - Interleukin-2 KW - Receptors, Transferrin KW - Interferons KW - 9008-11-1 KW - Abridged Index Medicus KW - Index Medicus KW - Interleukin-2 -- therapeutic use KW - Humans KW - Immunization, Passive KW - Immunotoxins -- therapeutic use KW - Receptors, Transferrin -- immunology KW - Interferons -- therapeutic use KW - Female KW - Antibodies, Monoclonal -- therapeutic use KW - Ovarian Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81011329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Biologic+therapy+for+the+treatment+of+malignant+common+epithelial+tumors+of+the+ovary.&rft.au=Hamilton%2C+T+C%3BOzols%2C+R+F%3BLongo%2C+D+L&rft.aulast=Hamilton&rft.aufirst=T&rft.date=1987-10-15&rft.volume=60&rft.issue=8+Suppl&rft.spage=2054&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-13 N1 - Date created - 1987-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Initial therapy for early ovarian carcinoma. AN - 81009750; 3308064 AB - Approximately 33% of women with invasive ovarian tumors present with what appears to be early epithelial ovarian cancer (FIGO Stages I and II) accounting for approximately 6000 new ovarian cancer cases each year in the United States. A better understanding of the natural history and patterns of spread of this disease has led to an increased awareness of the importance of thorough operative staging, cytoreductive surgery, and accurate determination of the extent of residual disease. These staging studies have documented frequent understaging of such patients. Results from such surgical staging studies indicate that only about 25% of women operated on in the United States have an initial surgical incision adequate to allow evaluation of the entire pelvis and abdominal cavity. As a result about 33% of patients thought to be free of disease at initial surgery have residual disease and in 75% the disease has spread intraabdominally. These studies have important implications for the design of future adjuvant trials. Fortunately, these accurate staging studies have defined groups of patients who require adjuvant treatment as well as those who do not. It is now apparent that certain groups of patients with Stage II and high-risk Stage I disease are at risk for failure throughout the abdominal cavity. Any form of adjuvant therapy, if it is to succeed, must obviously encompass this entire area. With this in mind, several prospective clinical trials have tested a variety of adjuvant approaches. Present evidence would suggest that systemic chemotherapy, intraperitoneal radioisotopes (32P) or whole abdominal irradiation have the potential to eradicate micrometastases throughout the area at risk. The need for adjuvant therapy is dependent upon the accuracy of initial surgical staging. If initial surgical evaluation was incomplete, the five year survival rates for Stage I (70%) and Stage II (40% to 50%) disease are poor enough that most investigators would advocate some sort of adjuvant therapy. However, comprehensive and accurate surgical staging will define subsets of ovarian cancer patients with such good prognoses (five year survival of 90% to 95%) that no adjuvant treatment is required. With the known risk of late second malignancies in ovarian cancer patients treated with long-term adjuvant chemotherapy, the identification of patients who do not require further treatment represents an advance. Accurate surgical staging coupled with proper adjuvant therapy designed to treat areas of high risk have improved the survival rate of patients with early ovarian cancer. JF - Cancer AU - Young, R C AD - Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/10/15/ PY - 1987 DA - 1987 Oct 15 SP - 2042 EP - 2049 VL - 60 IS - 8 Suppl SN - 0008-543X, 0008-543X KW - Cyclophosphamide KW - 8N3DW7272P KW - Cisplatin KW - Q20Q21Q62J KW - Melphalan KW - Q41OR9510P KW - Abridged Index Medicus KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Humans KW - Melphalan -- adverse effects KW - Prognosis KW - Clinical Trials as Topic KW - Melphalan -- therapeutic use KW - Female KW - Cisplatin -- administration & dosage KW - Ovarian Neoplasms -- mortality KW - Ovarian Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81009750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Initial+therapy+for+early+ovarian+carcinoma.&rft.au=Young%2C+R+C&rft.aulast=Young&rft.aufirst=R&rft.date=1987-10-15&rft.volume=60&rft.issue=8+Suppl&rft.spage=2042&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-13 N1 - Date created - 1987-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells. AN - 81009488; 2888531 AB - Bryostatin 1, a macrocyclic lactone, functions like the phorbol esters biochemically in binding to and activating protein kinase C. Biologically, however, although it induces some phorbol ester responses such as mitogenesis in Swiss 3T3 cells, it paradoxically blocks the effects of the phorbol esters on differentiation in HL-60 promyelocytic leukemia cells and Friend erythroleukemia cells. Since the phorbol esters induce proliferation and terminal differentiation in distinct subpopulations of epidermal basal cells, we have now examined the action of bryostatin 1 in that system. Bryostatin 1 decreased epidermal growth factor binding and induced ornithine decarboxylase activity, the latter a marker of proliferation. The magnitude of the maximal induction of ornithine decarboxylase was less than for phorbol 12,13-dibutyrate. Bryostatin 1 only transiently caused the morphological change typical of phorbol ester treatment and did not induce transglutaminase or cornified envelope production, markers of the differentiative pathway. Combined treatment with bryostatin 1 and phorbol 12,13-dibutyrate gave similar results to treatment with bryostatin 1 alone, i.e., slight reduction to complete inhibition of phorbol ester action, depending on the response. The mechanism may reflect time dependent block of the protein kinase C pathway by bryostatin 1 in this system; although bryostatin 1 inhibited epidermal growth factor binding at short incubation times (1-2 h), by 4 h of incubation its inhibition was markedly reduced and it correspondingly blocked inhibition of epidermal growth factor binding by phorbol 12,13-dibutyrate. Since induction of terminal differentiation is proposed to be an essential component of phorbol ester mediated tumor promotion in skin, our findings suggest that bryostatin 1 may function as an inhibitor of phorbol ester promotion. JF - Cancer research AU - Sako, T AU - Yuspa, S H AU - Herald, C L AU - Pettit, G R AU - Blumberg, P M AD - Molecular Mechanisms of Tumor Promotion Section, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/10/15/ PY - 1987 DA - 1987 Oct 15 SP - 5445 EP - 5450 VL - 47 IS - 20 SN - 0008-5472, 0008-5472 KW - Bryostatins KW - 0 KW - Lactones KW - Macrolides KW - Phorbol Esters KW - Dactinomycin KW - 1CC1JFE158 KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - bryostatin 1 KW - 37O2X55Y9E KW - Epidermal Growth Factor KW - 62229-50-9 KW - Cycloheximide KW - 98600C0908 KW - Transglutaminases KW - EC 2.3.2.13 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Enzyme Activation KW - Mice KW - Protein Kinase C -- metabolism KW - Ornithine Decarboxylase -- metabolism KW - Dactinomycin -- pharmacology KW - Epidermis -- drug effects KW - Transglutaminases -- metabolism KW - Cells, Cultured KW - Cycloheximide -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Epidermal Growth Factor -- metabolism KW - Phorbol Esters -- pharmacology KW - Skin Neoplasms -- chemically induced KW - Phorbol Esters -- antagonists & inhibitors KW - Lactones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81009488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Partial+parallelism+and+partial+blockade+by+bryostatin+1+of+effects+of+phorbol+ester+tumor+promoters+on+primary+mouse+epidermal+cells.&rft.au=Sako%2C+T%3BYuspa%2C+S+H%3BHerald%2C+C+L%3BPettit%2C+G+R%3BBlumberg%2C+P+M&rft.aulast=Sako&rft.aufirst=T&rft.date=1987-10-15&rft.volume=47&rft.issue=20&rft.spage=5445&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-12 N1 - Date created - 1987-11-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In situ hybridization studies on expression of albumin and alpha-fetoprotein during the early stage of neoplastic transformation in rat liver. AN - 81009169; 2443240 AB - The expressions of albumin and alpha-fetoprotein (AFP) genes were studied in early preneoplastic liver lesions produced by the Solt-Farber protocol using "in situ" hybridization with single stranded RNA probes. In normal rat liver, albumin was expressed at a lower level in the centrilobular than in the periportal areas of the liver acinus, whereas the bile duct epithelium did not show any expression. Five weeks after initiation with diethylnitrosamine, islands of hepatocytes were present which showed heterogeneous expression of albumin and were surrounded by cells comprised of albumin negative hepatocytes and oval cells. gamma-Glutamyltranspeptidase positive foci of enzyme altered cells were located in albumin positive areas. Albumin expression gradually decreased in permanent nodules but increased in the hepatocytes outside the nodules during the first five months after initiation with diethylnitrosamine. Remodeling nodules, which were partly gamma-glutamyltranspeptidase and albumin positive, were also present. However, no consistent correlation was found between gamma-glutamyltranspeptidase positive and albumin negative areas during the first 5 months after initiation. Occasionally, cells showing an elevated expression of albumin were found in permanent nodules. These cells were located in the vicinity of oval type cells, which also showed a weak expression of albumin. AFP was expressed at high level in oval cells 5 weeks after the initiation. However, oval cells observed at later time points, either around the neoplastic nodules or inside the nodules showed only low expression of AFP. Hepatocytes in the enzyme-altered foci and in neoplastic nodules were always negative for AFP. The presence of strongly albumin positive cells inside the neoplastic nodules in close proximity to oval type cells suggests that these cells may be derived from primitive "stem-cell"-like oval cells. JF - Cancer research AU - Evarts, R P AU - Nagy, P AU - Marsden, E AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/10/15/ PY - 1987 DA - 1987 Oct 15 SP - 5469 EP - 5475 VL - 47 IS - 20 SN - 0008-5472, 0008-5472 KW - Albumins KW - 0 KW - RNA, Messenger KW - alpha-Fetoproteins KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - Index Medicus KW - Rats KW - Animals KW - Liver -- pathology KW - Liver -- enzymology KW - RNA, Messenger -- analysis KW - Precancerous Conditions -- enzymology KW - Liver Neoplasms -- metabolism KW - alpha-Fetoproteins -- biosynthesis KW - Albumins -- biosynthesis KW - Liver Neoplasms -- enzymology KW - Cell Transformation, Neoplastic -- metabolism KW - Albumins -- genetics KW - Gene Expression Regulation KW - Nucleic Acid Hybridization KW - alpha-Fetoproteins -- genetics KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81009169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=In+situ+hybridization+studies+on+expression+of+albumin+and+alpha-fetoprotein+during+the+early+stage+of+neoplastic+transformation+in+rat+liver.&rft.au=Evarts%2C+R+P%3BNagy%2C+P%3BMarsden%2C+E%3BThorgeirsson%2C+S+S&rft.aulast=Evarts&rft.aufirst=R&rft.date=1987-10-15&rft.volume=47&rft.issue=20&rft.spage=5469&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-12 N1 - Date created - 1987-11-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Treatment-related cancers after gynecologic malignancy. AN - 81007860; 3308071 AB - Second malignancies are one of the known complications of cancer treatment. Several recent studies which have quantified the risk of treatment-induced cancers following gynecologic malignancies are reviewed. After cervical cancer, there is a 9% excess risk of second cancers, of which only 5% could be attributed to radiation therapy. Most of the treatment-related malignancies after cervical or endometrial cancer are solid tumors occurring within the radiation field. Following both cervical and endometrial cancer, there is a small increased risk of leukemia associated with radiation therapy. In contrast, after ovarian cancer, there is significantly increased risk of leukemia related to treatment with alkylating agents, which varies by drug type and total dose. The cumulative risk of leukemia and preleukemia following single agent melphalan is 11.2% +/- 2.6% at ten years; the risk after cyclophosphamide is 5.4% +/- 3.2%. Overall, the risk of second malignancies following treatment of gynecologic cancers is small. JF - Cancer AU - Tucker, M A AU - Fraumeni, J F AD - Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/10/15/ PY - 1987 DA - 1987 Oct 15 SP - 2117 EP - 2122 VL - 60 IS - 8 Suppl SN - 0008-543X, 0008-543X KW - Antineoplastic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Female KW - Neoplasms, Radiation-Induced -- etiology KW - Genital Neoplasms, Female -- therapy KW - Leukemia -- etiology KW - Radiotherapy -- adverse effects KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81007860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Treatment-related+cancers+after+gynecologic+malignancy.&rft.au=Tucker%2C+M+A%3BFraumeni%2C+J+F&rft.aulast=Tucker&rft.aufirst=M&rft.date=1987-10-15&rft.volume=60&rft.issue=8+Suppl&rft.spage=2117&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-13 N1 - Date created - 1987-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - American Cancer Society workshop on tumor promotion and antipromotion. AN - 81005215; 3652052 JF - Cancer research AU - Colburn, N H AU - Farber, E AU - Weinstein, E B AU - Diamond, L AU - Slaga, T J AD - National Cancer Institute, Frederick Cancer Research Facility, MD 21701. Y1 - 1987/10/15/ PY - 1987 DA - 1987 Oct 15 SP - 5509 EP - 5513 VL - 47 IS - 20 SN - 0008-5472, 0008-5472 KW - Carcinogens KW - 0 KW - Index Medicus KW - Animals KW - Precancerous Conditions KW - Neoplasms, Experimental -- etiology KW - Humans KW - Neoplasms -- prevention & control KW - Neoplasms -- genetics KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81005215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=American+Cancer+Society+workshop+on+tumor+promotion+and+antipromotion.&rft.au=Colburn%2C+N+H%3BFarber%2C+E%3BWeinstein%2C+E+B%3BDiamond%2C+L%3BSlaga%2C+T+J&rft.aulast=Colburn&rft.aufirst=N&rft.date=1987-10-15&rft.volume=47&rft.issue=20&rft.spage=5509&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-12 N1 - Date created - 1987-11-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hydrogen bonding between cytosine and peptides of threonine or serine: is it relevant to the origin of the genetic code? AN - 81103581; 3118873 AB - 13C, 15N, and 1H nuclear magnetic resonance measurements indicate that chloroform-soluble threonine-containing tripeptide derivatives, such as t-Boc-Thr-Gly-Gly-OBz, form three strong hydrogen bonds to the cytosine moiety of 2',3'-O-isopropylidene-5'-O-t-butyldimethylsilylcytidine. The C = O and NH of the central peptide residue plus the OH of the threonine side chain appear to form bonds to the N(4')H2, N(3), and C(2) = O, respectively, of the pyrimidine. An association constant calculated from the cytidine 15N(4') nuclear magnetic resonance response to added peptide is four times larger than the corresponding cytosine-guanine constant. It is suggested that cytosine-peptide bonding was part of the primitive genetic coding mechanism early in evolution and accounts for the origin of the cytosine-centered codons for the hydroxy amino acids, serine and threonine, in the present code. JF - Biochemical and biophysical research communications AU - Niu, C H AU - Han, K H AU - Yeh, H J AU - Black, S AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/10/14/ PY - 1987 DA - 1987 Oct 14 SP - 456 EP - 462 VL - 148 IS - 1 SN - 0006-291X, 0006-291X KW - Codon KW - 0 KW - Oligopeptides KW - Threonine KW - 2ZD004190S KW - Serine KW - 452VLY9402 KW - Cytosine KW - 8J337D1HZY KW - Index Medicus KW - Nucleic Acid Conformation KW - Hydrogen Bonding KW - Protein Conformation KW - Magnetic Resonance Spectroscopy KW - Genetic Code UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81103581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Hydrogen+bonding+between+cytosine+and+peptides+of+threonine+or+serine%3A+is+it+relevant+to+the+origin+of+the+genetic+code%3F&rft.au=Niu%2C+C+H%3BHan%2C+K+H%3BYeh%2C+H+J%3BBlack%2C+S&rft.aulast=Niu&rft.aufirst=C&rft.date=1987-10-14&rft.volume=148&rft.issue=1&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-01 N1 - Date created - 1987-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic morphine upregulates a mu-opiate binding site labeled by [3H]cycloFOXY: a novel opiate antagonist suitable for positron emission tomography. AN - 77870003; 2826178 AB - CycloFOXY (17-cyclopropylmethyl-3,14-dihydroxy-4,5-alpha-epoxy-6-beta- fluoromorphinan) is a novel opiate antagonist synthesized as a ligand suitable for in vivo visualization of opiate receptors using positron emission transaxial tomography. In this paper we report that [3H]cycloFOXY labels two distinct opiate binding sites in rat brain membranes, tentatively identified as mu and kappa. Furthermore, chronic administration of morphine results in a selective up-regulation of the mu binding site. The implications of this finding for models of the opioid receptors and the mechanism of the sodium effect are discussed. JF - European journal of pharmacology AU - Rothman, R B AU - McLean, S AU - Bykov, V AU - Lessor, R A AU - Jacobson, A E AU - Rice, K C AU - Holaday, J W AD - Laboratory of Preclinical Pharmacology, St. Elizabeths Hospital, NIMH, Washington, DC 20032. Y1 - 1987/10/06/ PY - 1987 DA - 1987 Oct 06 SP - 73 EP - 81 VL - 142 IS - 1 SN - 0014-2999, 0014-2999 KW - Alkylating Agents KW - 0 KW - Receptors, Opioid KW - Receptors, Opioid, mu KW - Naloxone KW - 36B82AMQ7N KW - Enkephalin, Leucine KW - 58822-25-6 KW - Naltrexone KW - 5S6W795CQM KW - Morphine KW - 76I7G6D29C KW - 3-acetyl-6-deoxy-6-fluoronaltrexone KW - 94696-53-4 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Naloxone -- pharmacology KW - Drug Tolerance KW - Animals KW - Alkylating Agents -- pharmacology KW - In Vitro Techniques KW - Enkephalin, Leucine -- metabolism KW - Tomography, Emission-Computed KW - Binding, Competitive -- drug effects KW - Male KW - Receptors, Opioid -- metabolism KW - Naltrexone -- analogs & derivatives KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77870003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Chronic+morphine+upregulates+a+mu-opiate+binding+site+labeled+by+%5B3H%5DcycloFOXY%3A+a+novel+opiate+antagonist+suitable+for+positron+emission+tomography.&rft.au=Rothman%2C+R+B%3BMcLean%2C+S%3BBykov%2C+V%3BLessor%2C+R+A%3BJacobson%2C+A+E%3BRice%2C+K+C%3BHoladay%2C+J+W&rft.aulast=Rothman&rft.aufirst=R&rft.date=1987-10-06&rft.volume=142&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Retropseudogenes for human chromosomal protein HMG-17. AN - 77960626; 3441004 AB - The human genome contains multiple copies of sequences homologous to the cDNA coding for non-histone chromosomal protein HMG-17. To study the mechanism of generation and dispersion of the HMG-17 multigene family a human genomic library was screened and 70 clones isolated and studied by Southern transfer and restriction site analysis. The results suggest that most of the clones contain unique sequences. Sequence analysis of two genomic clones indicates that they contain elements typical of processed retropseudogenes. Even though both sequences contained open reading frames the sequences lacked introns, were flanked by short, direct repeats and lacked elements associated with functional genes. The sequences of the two pseudogenes were 85% homologous to each other and each was 90% homologous to the human cDNA. Based on the sequence difference in the open reading frame between the pseudogenes and the cDNA it can be estimated that the sequences arose approximately ten million years ago from a common precursor. The present paper, which is the first study on genes coding for this nucleosomal binding protein, indicates that the HMG-17 multigene family is the largest known human retropseudogene family. JF - Journal of molecular biology AU - Srikantha, T AU - Landsman, D AU - Bustin, M AD - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/10/05/ PY - 1987 DA - 1987 Oct 05 SP - 405 EP - 413 VL - 197 IS - 3 SN - 0022-2836, 0022-2836 KW - Chromosomal Proteins, Non-Histone KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Base Sequence KW - Sequence Homology, Nucleic Acid KW - Multigene Family KW - Humans KW - DNA -- genetics KW - Molecular Sequence Data KW - Pseudogenes KW - Chromosomal Proteins, Non-Histone -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77960626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Retropseudogenes+for+human+chromosomal+protein+HMG-17.&rft.au=Srikantha%2C+T%3BLandsman%2C+D%3BBustin%2C+M&rft.aulast=Srikantha&rft.aufirst=T&rft.date=1987-10-05&rft.volume=197&rft.issue=3&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-18 N1 - Date created - 1988-04-18 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - X06444; GENBANK; X06353 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interaural attenuation for tubephone insert earphones. AN - 85168398; pmid-3678645 AB - Interaural attenuation of pure tone and speech signals was evaluated for a new audiometric insert earphone, the ER-3A tubephone, and a conventional TDH-49P supra-aural earphone in seven unilaterally deaf adult subjects. These results validate and extend the interaural attenuation data reported by the manufacturer of the ER-3A and his associates. At frequencies of 0.5 to 1 kHz, mean interaural attenuation for the deeply inserted ER-3A decreased from 94+ dB to 81 dB, with the lowest value for any subject, 75 dB. Interaural attenuation for speech approximated that of the 1 to 2 kHz frequency range. The ER-3A tubephone provides significantly greater acoustic isolation between the two ears in the low-mid frequency audiometric range than the conventional supra-aural earphone. JF - Ear and Hearing AU - Sklare, D A AU - Denenberg, L J AD - Clinical Audiology, National Institutes of Health, Bethesda, Maryland. PY - 1987 SP - 298 EP - 300 VL - 8 IS - 5 SN - 0196-0202, 0196-0202 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85168398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+Hearing&rft.atitle=Interaural+attenuation+for+tubephone+insert+earphones.&rft.au=Sklare%2C+D+A%3BDenenberg%2C+L+J&rft.aulast=Sklare&rft.aufirst=D&rft.date=1987-10-01&rft.volume=8&rft.issue=5&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Ear+and+Hearing&rft.issn=01960202&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Simulating failure times when the event of interest is unobservable with emphasis on animal carcinogenicity studies. AN - 81107699; 3677627 AB - This paper discusses and summarizes the methods which can be used to simulate failure times when an intermediate event of interest is unobservable. Data from animal carcinogenicity experiments are typically of this form. The simulation of time-to-event data where cause of failure is known and the case where cause of failure is unknown are discussed. The methods proposed for simulating failure times use identifiable hazard functions and allow for random sampling of functioning experimental units at fixed times. Some useful design and programming tools are also given. JF - Computers and biomedical research, an international journal AU - Portier, C J AU - Bailer, A J AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 458 EP - 466 VL - 20 IS - 5 SN - 0010-4809, 0010-4809 KW - Index Medicus KW - Probability KW - Animals KW - Algorithms KW - Time Factors KW - Research Design KW - Cause of Death KW - Computer Simulation KW - Mutagenicity Tests -- methods KW - Mathematical Computing KW - Data Interpretation, Statistical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81107699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+and+biomedical+research%2C+an+international+journal&rft.atitle=Simulating+failure+times+when+the+event+of+interest+is+unobservable+with+emphasis+on+animal+carcinogenicity+studies.&rft.au=Portier%2C+C+J%3BBailer%2C+A+J&rft.aulast=Portier&rft.aufirst=C&rft.date=1987-10-01&rft.volume=20&rft.issue=5&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Computers+and+biomedical+research%2C+an+international+journal&rft.issn=00104809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-12 N1 - Date created - 1988-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The United States' drug abuse scene: an overview. AN - 81105726; 3315311 JF - Clinical chemistry AU - Schuster, C R AD - National Institute on Drug Abuse, Rockville, MD 20857. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 7B EP - 12B VL - 33 IS - 11 Suppl SN - 0009-9147, 0009-9147 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - United States KW - Humans KW - Adult KW - Cannabis KW - Adolescent KW - Substance-Related Disorders KW - Legislation, Drug UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81105726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry&rft.atitle=The+United+States%27+drug+abuse+scene%3A+an+overview.&rft.au=Schuster%2C+C+R&rft.aulast=Schuster&rft.aufirst=C&rft.date=1987-10-01&rft.volume=33&rft.issue=11+Suppl&rft.spage=7B&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-04 N1 - Date created - 1988-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Thyroid hormones regulate levels of thyrotropin-releasing-hormone mRNA in the paraventricular nucleus. AN - 81080615; 3118365 AB - Cellular levels of messenger RNA encoding thyrotropin-releasing hormone (TRH) were measured in the paraventricular nucleus of the hypothalamus and the reticular nucleus of the thalamus in male rats after chemical thyroidectomy and thyroid hormone replacement. TRH mRNA levels were measured by quantitative in situ hybridization histochemistry using a 35S-labeled synthetic 48-base oligodeoxynucleotide probe and quantitative autoradiography. Chemical thyroidectomy, produced by the administration of 6-(n-propyl)-2-thiouracil (PrSur), reduced plasma thyroxine below detection limits and significantly increased TRH mRNA in the paraventricular nucleus. Treatment with exogenous L-triiodothyronine (T3) reduced TRH mRNA to the same level in both hypothyroid and euthyroid animals. Neither PrSur treatment nor T3 replacement influenced TRH mRNA levels in the reticular nucleus of the thalamus. Blot hybridization analysis of electrophoretically fractionated total RNA from pituitaries of these animals indicated that thyrotropin-beta mRNA levels were elevated after thyroidectomy and reduced by T3 treatment, showing that the pituitary-thyroid axis was indeed stimulated by PrSur treatment. These results suggest that thyroid hormones are involved, either directly or indirectly, in regulating the biosynthesis of TRH in the thyrotropic center of the hypothalamus. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Koller, K J AU - Wolff, R S AU - Warden, M K AU - Zoeller, R T AD - Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 7329 EP - 7333 VL - 84 IS - 20 SN - 0027-8424, 0027-8424 KW - RNA, Messenger KW - 0 KW - Triiodothyronine KW - 06LU7C9H1V KW - Thyrotropin-Releasing Hormone KW - 5Y5F15120W KW - Propylthiouracil KW - 721M9407IY KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Hypothalamo-Hypophyseal System -- physiology KW - Animals KW - Propylthiouracil -- toxicity KW - Hypothyroidism -- metabolism KW - Gene Expression Regulation KW - Feedback KW - Hypothyroidism -- chemically induced KW - Male KW - Paraventricular Hypothalamic Nucleus -- metabolism KW - Triiodothyronine -- pharmacology KW - Thalamic Nuclei -- metabolism KW - Thyrotropin-Releasing Hormone -- biosynthesis KW - Thyrotropin-Releasing Hormone -- genetics KW - Thalamic Nuclei -- drug effects KW - Paraventricular Hypothalamic Nucleus -- drug effects KW - RNA, Messenger -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81080615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Thyroid+hormones+regulate+levels+of+thyrotropin-releasing-hormone+mRNA+in+the+paraventricular+nucleus.&rft.au=Koller%2C+K+J%3BWolff%2C+R+S%3BWarden%2C+M+K%3BZoeller%2C+R+T&rft.aulast=Koller&rft.aufirst=K&rft.date=1987-10-01&rft.volume=84&rft.issue=20&rft.spage=7329&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-25 N1 - Date created - 1987-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Endocrinology. 1974 Jan;94(1):188-97 [4202988] Neuroendocrinology. 1971;8(5):273-88 [4106747] Nucleic Acids Res. 1977;4(5):1539-52 [19730] Biochemistry. 1979 Nov 27;18(24):5294-9 [518835] Endocrinology. 1981 Nov;109(5):1731-8 [6795032] Endocr Rev. 1981 Fall;2(4):396-436 [6118265] Nature. 1982 Jul 8;298(5870):163-5 [7088171] Nature. 1983 Nov 3-9;306(5938):84-5 [6415487] J Biol Chem. 1984 Feb 25;259(4):2166-70 [6546571] Neuropeptides. 1983 Dec;4(1):1-9 [6199686] Anal Biochem. 1984 Feb;137(1):266-7 [6329026] Neuroendocrinology. 1984 Aug;39(2):170-5 [6332279] Endocrinology. 1985 Mar;116(3):873-8 [2578951] Nature. 1985 May 2-8;315(6014):59-61 [3873012] Biochem Biophys Res Commun. 1985 May 16;128(3):1152-8 [3839124] J Mol Biol. 1985 May 5;183(1):1-12 [4009718] Science. 1986 Jan 10;231(4734):159-61 [3079917] J Neurosci. 1986 Jan;6(1):38-42 [3753720] Science. 1986 Apr 18;232(4748):390-3 [3961487] Annu Rev Neurosci. 1986;9:277-304 [3518586] Endocrinology. 1986 Sep;119(3):1210-6 [3089766] Proc Natl Acad Sci U S A. 1986 Dec;83(24):9827-31 [2432603] Nature. 1977 Jun 30;267(5614):853-4 [408707] Neuroendocrinology. 1971;7(1):37-45 [5543247] Endocrinology. 1977 Jun;100(6):1604-9 [140045] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of mouse mammary tumor virus gag-pro gene products and the ribosomal frameshift site by protein sequencing. AN - 81080431; 2823251 AB - The synthesis of retroviral polyproteins that are the translational products of the genome-size mRNA is initiated in the upstream gag gene. The synthesis of the products of the protease gene (pro) and polymerase gene (pol) is regulated by translational suppression (in-frame read-through or frameshift) of termination codons as a strategy developed for controlling the level of replicative enzymes required only in catalytic amounts. In mouse mammary tumor virus (MMTV), three overlapping reading frames are utilized for the synthesis of gag-encoded Pr77, gag-pro-encoded Pr110, and gag-pro-pol-encoded Pr160 polyproteins. To characterize pro gene products and to determine the site of frameshift required for the synthesis of Pr110, we purified and sequenced three MMTV proteins: p14, p30, and p13. Sequence analysis showed that p14 is the basic nucleic acid-binding protein derived entirely from gag, and p13 is a product of the pro gene and has characteristic sequences of protease. A comparison of the amino acid sequences of p30 with the corresponding nucleotide sequence of proviral DNA allowed the delineation of the frameshift site utilized in vivo for the synthesis of the gag-pro-encoded fusion polyprotein Pr110. The results showed that: (i) the N-terminal 94 residues of p30 are translated from the gag frame; (ii) residue leucine-95 is specified by either the last UUG codon of gag or the overlapping CUU codon in the pro frame; and (iii) the elongation of the peptide chain from residue 96 continued to be encoded in the pro frame to the pro terminator. The possible mechanisms of frameshift and of the tRNAs involved are discussed. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Hizi, A AU - Henderson, L E AU - Copeland, T D AU - Sowder, R C AU - Hixson, C V AU - Oroszlan, S AD - Laboratory of Molecular Virology and Carcinogenesis, Bionetics Research, Inc.-Basic Research Program, National Cancer Institute-Frederick Cancer Research Facility, MD 21701. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 7041 EP - 7045 VL - 84 IS - 20 SN - 0027-8424, 0027-8424 KW - Gene Products, gag KW - 0 KW - RNA, Messenger KW - RNA, Viral KW - Retroviridae Proteins KW - RNA, Transfer KW - 9014-25-9 KW - Index Medicus KW - Ribosomes -- metabolism KW - RNA, Transfer -- physiology KW - Base Sequence KW - Amino Acid Sequence KW - RNA, Viral -- genetics KW - RNA, Messenger -- genetics KW - Protein Biosynthesis KW - Retroviridae Proteins -- biosynthesis KW - Genes KW - Retroviridae Proteins -- genetics KW - Genes, Overlapping KW - Genes, Viral KW - Retroviridae Proteins -- isolation & purification KW - Mammary Tumor Virus, Mouse -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81080431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Characterization+of+mouse+mammary+tumor+virus+gag-pro+gene+products+and+the+ribosomal+frameshift+site+by+protein+sequencing.&rft.au=Hizi%2C+A%3BHenderson%2C+L+E%3BCopeland%2C+T+D%3BSowder%2C+R+C%3BHixson%2C+C+V%3BOroszlan%2C+S&rft.aulast=Hizi&rft.aufirst=A&rft.date=1987-10-01&rft.volume=84&rft.issue=20&rft.spage=7041&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-25 N1 - Date created - 1987-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1970 Aug 15;227(5259):680-5 [5432063] Proc Natl Acad Sci U S A. 1987 Jun;84(12):4298-302 [3035577] J Biol Chem. 1981 Aug 10;256(15):7990-7 [7263636] Cell. 1983 Mar;32(3):853-69 [6299578] J Virol. 1983 May;46(2):355-61 [6302307] J Virol. 1983 Oct;48(1):314-9 [6310154] Curr Top Microbiol Immunol. 1983;106:1-34 [6196157] Proc Natl Acad Sci U S A. 1984 Sep;81(18):5797-801 [6592589] J Virol. 1984 Nov;52(2):492-500 [6333515] Nature. 1984 Dec 13-19;312(5995):659-61 [6209583] Proc Natl Acad Sci U S A. 1985 Mar;82(6):1618-22 [3885215] Proc Natl Acad Sci U S A. 1985 May;82(9):2829-33 [2581255] J Virol. 1985 Sep;55(3):870-3 [2991607] Virology. 1985 Apr 30;142(2):357-77 [2997990] Nature. 1985 Dec 12-18;318(6046):583-6 [2415827] Science. 1985 Dec 13;230(4731):1237-42 [2416054] J Virol. 1986 Mar;57(3):826-32 [3005629] Science. 1986 Mar 28;231(4745):1567-72 [3006247] Cell. 1986 May 9;45(3):375-85 [2421920] J Biol Chem. 1986 Jun 5;261(16):7491-500 [3711097] J Virol. 1987 Feb;61(2):480-90 [3027377] Proc Natl Acad Sci U S A. 1987 May;84(9):2668-72 [3472229] Proc Natl Acad Sci U S A. 1978 Mar;75(3):1404-8 [206897] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The detection of blood on nonporous environmental surfaces: an approach for assessing factors contributing to the risk of occupational exposure to blood in the autopsy suite. AN - 81063227; 3667120 AB - A simple and inexpensive method to assess the contamination of environmental surfaces and the associated potential risk of exposure of autopsy room personnel to potentially hazardous materials is described. Blood was selected as a marker of contamination and HEMASTIX reagent strips were used to determine its presence on selected surfaces. The surfaces selected for examination typically do not come into direct contact with cadavers or tissues during a routine postmortem examination and thus are not included in routine cleanup. We documented the presence of blood on a variety of environmental surfaces in the autopsy suite and suggest that the contamination resulted from a breakdown in good work practices, most probably the indiscriminate handling or touching of materials and equipment with contaminated gloves. The risk of exposure to blood by the indirect route was deemed significant. The results of this study underscore the importance of establishing and consistently following good work practices and cleanup procedures to minimize the risk of exposure to blood before, during, and after postmortem examinations. JF - Infection control : IC AU - Beaumont, L R AD - Occupational Safety and Health Branch, National Institutes of Health, Bethesda, Maryland 20892. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 424 EP - 426 VL - 8 IS - 10 SN - 0195-9417, 0195-9417 KW - Reagent Strips KW - 0 KW - Index Medicus KW - Nursing KW - Risk Factors KW - Humans KW - Occupational Diseases -- prevention & control KW - Pathology, Clinical KW - Blood Stains KW - Cross Infection -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81063227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+control+%3A+IC&rft.atitle=The+detection+of+blood+on+nonporous+environmental+surfaces%3A+an+approach+for+assessing+factors+contributing+to+the+risk+of+occupational+exposure+to+blood+in+the+autopsy+suite.&rft.au=Beaumont%2C+L+R&rft.aulast=Beaumont&rft.aufirst=L&rft.date=1987-10-01&rft.volume=8&rft.issue=10&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Infection+control+%3A+IC&rft.issn=01959417&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-14 N1 - Date created - 1987-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Validation and application of a liquid-chromatographic/enzymatic assay for individual bile acids in the serum of rats. AN - 81063190; 3665040 AB - A liquid-chromatographic technique with a post-column enzymatic reaction and fluorescence detection was validated for analysis of individual bile acids in the serum of rats. Extraction recoveries averaged 91.1% (SD 6.9%) for all bile acids. The assay was sensitive (minimum detection of 16.8 pmol per 100-microL injection), linear (r greater than 0.999 for concentrations ranging between 45 and 112,500 pmol per 100-microL injection), and reproducible (mean CVs for three different concentrations of standards and a serum pool ranged from 4.4% to 12.2%). In rats treated for three days with either neomycin, carbon tetrachloride, alpha-naphthylisothiocyanate, or total bile-duct ligation (five animals per group), total concentrations of bile acids were significantly increased (P less than 0.004). Concentrations of 16 of 17 individual bile acids differed significantly between groups (P less than 0.04). Examination of the relative concentrations (percent of total) of individual bile acids by canonical discriminant analysis placed each animal into the appropriate treatment or control group. Use of this technique in toxicological studies can help detect and identify specific types of disruptions in the enterohepatic circulation of bile acids. JF - Clinical chemistry AU - Thompson, M B AU - Blair, P C AU - Morris, R W AU - Neptun, D A AU - Deyo, D F AU - Popp, J A AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 1856 EP - 1862 VL - 33 IS - 10 SN - 0009-9147, 0009-9147 KW - Bile Acids and Salts KW - 0 KW - Neomycin KW - 1404-04-2 KW - 1-Naphthylisothiocyanate KW - 551-06-4 KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Index Medicus KW - Rats KW - Carbon Tetrachloride -- pharmacology KW - Animals KW - Rats, Inbred F344 KW - Bile Ducts KW - Enterohepatic Circulation -- drug effects KW - Chromatography, High Pressure Liquid -- methods KW - Ligation KW - Fluorometry KW - 1-Naphthylisothiocyanate -- pharmacology KW - Liver Function Tests KW - Neomycin -- pharmacology KW - Female KW - Bile Acids and Salts -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81063190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry&rft.atitle=Validation+and+application+of+a+liquid-chromatographic%2Fenzymatic+assay+for+individual+bile+acids+in+the+serum+of+rats.&rft.au=Thompson%2C+M+B%3BBlair%2C+P+C%3BMorris%2C+R+W%3BNeptun%2C+D+A%3BDeyo%2C+D+F%3BPopp%2C+J+A&rft.aulast=Thompson&rft.aufirst=M&rft.date=1987-10-01&rft.volume=33&rft.issue=10&rft.spage=1856&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-25 N1 - Date created - 1987-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Relationship between 7,12-dimethyl- and 7,8,12-trimethylbenz[a]anthracene DNA adduct formation in hematopoietic organs and leukemogenic effects. AN - 81056869; 3117352 AB - The leukemogens 7,12-dimethylbenz[a]anthracene (DMBA) and 7,8,12-trimethylbenz[a]anthracene (TMBA) bind covalently in vivo to DNA of Long-Evans rats in the hematopoietic organs, spleen and bone marrow, and in the liver, a non-target organ. Both TMBA and DMBA depleted bone marrow cells and both agents bound persistently to the DNA of bone marrow and of liver, and less to that of spleen. The three main DMBA:deoxyribonucleoside adducts in spleen, bone marrow and liver were the same as those found previously in the liver (Dipple et al. (1983) Cancer Res., 43, 4132). There were no organ-specific or age-dependent differences in the relative amounts of adducts formed. There appears to be no direct correlation between the susceptibility of an organ to carcinogenesis and the nature and relative amount of the specific adducts formed, at least for the three organs studied here. JF - Cancer letters AU - Falzon, M AU - Vu, V T AU - Roller, P P AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 41 EP - 49 VL - 37 IS - 1 SN - 0304-3835, 0304-3835 KW - 7,8,12-trimethylbenz(a)anthracene KW - 13345-64-7 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Rats KW - Animals KW - Spleen -- metabolism KW - Liver -- metabolism KW - Bone Marrow -- metabolism KW - Leukemia, Experimental -- chemically induced KW - Female KW - 9,10-Dimethyl-1,2-benzanthracene -- analogs & derivatives KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - DNA -- metabolism KW - 9,10-Dimethyl-1,2-benzanthracene -- metabolism KW - Hematopoietic System -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81056869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Relationship+between+7%2C12-dimethyl-+and+7%2C8%2C12-trimethylbenz%5Ba%5Danthracene+DNA+adduct+formation+in+hematopoietic+organs+and+leukemogenic+effects.&rft.au=Falzon%2C+M%3BVu%2C+V+T%3BRoller%2C+P+P%3BThorgeirsson%2C+S+S&rft.aulast=Falzon&rft.aufirst=M&rft.date=1987-10-01&rft.volume=37&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-23 N1 - Date created - 1987-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metallothionein gene regulation in Menkes' syndrome. AN - 81054794; 3662572 AB - The characteristic feature of Menkes' disease is a maldistribution of bodily copper; decreased copper levels are present in the serum, brain, and liver, whereas excess levels are present in gut, kidney, and most other nonhepatic tissues. Using cultured fibroblasts, we have shown that low extracellular copper concentrations induce synthesis of metallothionein, a copper-binding protein, in Menkes' cells but not in normal cells. This is due to a defect in a diffusable regulatory factor that is probably involved in copper metabolism. To further understand the role of the defective factor in transcription, assays have been developed to study the metal-dependent binding of nuclear proteins to metallothionein gene control sequences. JF - Archives of dermatology AU - Hamer, D H AD - Laboratory of Biochemistry, National Cancer Institute, Bethesda, Md 20892. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 1384a EP - 1385a VL - 123 IS - 10 SN - 0003-987X, 0003-987X KW - Transcription Factors KW - 0 KW - Copper KW - 789U1901C5 KW - Metallothionein KW - 9038-94-2 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Transcription Factors -- metabolism KW - Cells, Cultured KW - Humans KW - Transcription, Genetic KW - Mice KW - Copper -- toxicity KW - Menkes Kinky Hair Syndrome -- genetics KW - Brain Diseases, Metabolic -- genetics KW - Metallothionein -- genetics KW - Gene Expression Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81054794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+dermatology&rft.atitle=Metallothionein+gene+regulation+in+Menkes%27+syndrome.&rft.au=Hamer%2C+D+H&rft.aulast=Hamer&rft.aufirst=D&rft.date=1987-10-01&rft.volume=123&rft.issue=10&rft.spage=1384a&rft.isbn=&rft.btitle=&rft.title=Archives+of+dermatology&rft.issn=0003987X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-09 N1 - Date created - 1987-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - NHLBI workshop summary. Effects of tobacco smoke components on cellular and biochemical processes in the lung. AN - 81054651; 3310769 JF - The American review of respiratory disease AU - Janoff, A AU - Pryor, W A AU - Bengali, Z H AD - Division of Lung Diseases, NHLBI, Bethesda, MD 20892. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 1058 EP - 1064 VL - 136 IS - 4 SN - 0003-0805, 0003-0805 KW - Smoke KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Plants, Toxic KW - Smoke -- adverse effects KW - Animals KW - National Institutes of Health (U.S.) KW - Tobacco KW - Smoke -- analysis KW - Pneumonia -- etiology KW - Lung -- cytology KW - Lung -- drug effects KW - Smoking -- adverse effects KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81054651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=NHLBI+workshop+summary.+Effects+of+tobacco+smoke+components+on+cellular+and+biochemical+processes+in+the+lung.&rft.au=Janoff%2C+A%3BPryor%2C+W+A%3BBengali%2C+Z+H&rft.aulast=Janoff&rft.aufirst=A&rft.date=1987-10-01&rft.volume=136&rft.issue=4&rft.spage=1058&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-06 N1 - Date created - 1987-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Quantitation of cellular and extracellular constituents of the pulmonary lining in rats by using bronchoalveolar lavage. Effects of silica-induced pulmonary inflammation. AN - 81053679; 3662242 AB - The efficacy of bronchoalveolar lavage in the removal of cellular and extracellular components of the lining layer from the lungs of silica-treated and control rats was determined. Exponential functions were fitted to curves generated by plotting the quantity of lining layer constituent removed from the lungs by bronchoalveolar lavage versus the lavage number. From these exponential functions we determined the total amount of constituent available in the pulmonary extracellular lining and hence the efficacy of the lavage procedure in removing materials from the lungs. With control rats the removal of extracellular phospholipids, soluble protein, alkaline phosphatase, and beta-N-acetylglucosaminidase by bronchoalveolar lavage occurred at significantly different rates. Removal of 95% of the total available extracellular phospholipid, beta-N-acetylglucosaminidase, soluble protein, and alkaline phosphatase from the lungs required 4, 4, 8, and 11 lavages, respectively. Removal of 95% of the total available alveolar macrophages required 18 lavages. The influence of pulmonary inflammation on the efficacy of the lavage procedure was investigated by injecting silica dust intratracheally into the lungs of rats (50 mg/200- to 250-g rat) and after 3 days performing the analyses. Silica caused an inflammatory condition in the lungs resulting in the accumulation of materials in the alveoli. Highly significant increases in soluble protein (16-fold), alkaline phosphatase (9-fold), and beta-N-acetylglucosaminidase (11-fold), polymorphonuclear leukocytes, eosinophils, and lymphocytes were observed. Alveolar macrophages and extracellular phospholipid were not significantly elevated at 3 days after dosing. Silica did not alter the efficacy of the lavage procedure in removing from the lungs any of the extracellular constituents of the lung lining.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American review of respiratory disease AU - Dethloff, L A AU - Gladen, B C AU - Gilmore, L B AU - Hook, G E AD - Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 899 EP - 907 VL - 136 IS - 4 SN - 0003-0805, 0003-0805 KW - Hydrolases KW - EC 3.- KW - Abridged Index Medicus KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Methods KW - Microscopy, Electron KW - Hydrolases -- analysis KW - Male KW - Mathematics KW - Extracellular Space -- analysis KW - Silicosis -- pathology KW - Bronchoalveolar Lavage Fluid -- analysis KW - Lung -- ultrastructure KW - Lung -- enzymology KW - Extracellular Space -- enzymology KW - Silicosis -- enzymology KW - Bronchoalveolar Lavage Fluid -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81053679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Quantitation+of+cellular+and+extracellular+constituents+of+the+pulmonary+lining+in+rats+by+using+bronchoalveolar+lavage.+Effects+of+silica-induced+pulmonary+inflammation.&rft.au=Dethloff%2C+L+A%3BGladen%2C+B+C%3BGilmore%2C+L+B%3BHook%2C+G+E&rft.aulast=Dethloff&rft.aufirst=L&rft.date=1987-10-01&rft.volume=136&rft.issue=4&rft.spage=899&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-06 N1 - Date created - 1987-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differentiating among proposed mechanisms for tumor promotion in mouse skin with the use of the multievent model for cancer. AN - 81034819; 3116311 AB - Numerous mechanisms for tumor promotion in mouse skin have been recently proposed. These include the multistage, genetic view of Slaga, Furstenberger, and Marks; the multistage, genetic and/or epigenetic view of Parkinson; and the two-stage view of Yuspa and Hennings. With the use of the multievent model, a mathematical model for cancer that can incorporate cell proliferation phenomena, these tumor promotion mechanisms were modeled mathematically. It was found that the models had different predictions about the incidence of papillomas in initiator-promoter-initiator experiments and the incidence of carcinomas in initiator-promoter experiments with varying periods of tumor promotion. Upon analysis, existing data were shown to be in agreement with the Yuspa and Hennings two-stage model. The analysis also supported the view, formulated by Scribner and co-workers, that different types of initiated cells were created, some capable of transformation to carcinomas and some not. Phenomena determined by use of benign tumors as the end point may need to be demonstrated with the use of the carcinoma as the end point, prior to the acceptance of these phenomena being applicable to the human carcinogenic process. JF - Journal of the National Cancer Institute AU - Chu, K C AU - Brown, C C AU - Tarone, R E AU - Tan, W Y AD - Early Detection Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 789 EP - 796 VL - 79 IS - 4 SN - 0027-8874, 0027-8874 KW - Acetone KW - 1364PS73AF KW - Urethane KW - 3IN71E75Z5 KW - 4-Nitroquinoline-1-oxide KW - 56-57-5 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Papilloma -- pathology KW - Mice KW - Papilloma -- chemically induced KW - Mathematics KW - Skin Neoplasms -- chemically induced KW - Skin Neoplasms -- pathology KW - Models, Biological KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81034819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Differentiating+among+proposed+mechanisms+for+tumor+promotion+in+mouse+skin+with+the+use+of+the+multievent+model+for+cancer.&rft.au=Chu%2C+K+C%3BBrown%2C+C+C%3BTarone%2C+R+E%3BTan%2C+W+Y&rft.aulast=Chu&rft.aufirst=K&rft.date=1987-10-01&rft.volume=79&rft.issue=4&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-06 N1 - Date created - 1987-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A guide for performing germ cell mutagenesis assays using Drosophila melanogaster. AN - 81032434; 3116424 JF - Mutation research AU - Mason, J M AU - Aaron, C S AU - Lee, W R AU - Smith, P D AU - Thakar, A AU - Valencia, R AU - Woodruff, R C AU - Würgler, F E AU - Zimmering, S AD - Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 93 EP - 102 VL - 189 IS - 2 SN - 0027-5107, 0027-5107 KW - Mutagens KW - 0 KW - Index Medicus KW - Animals KW - Drosophila melanogaster -- genetics KW - Drosophila melanogaster -- drug effects KW - Statistics as Topic KW - Research Design KW - Genes, Lethal KW - Translocation, Genetic KW - Genes, Recessive KW - Mutagens -- analysis KW - Germ Cells -- drug effects KW - Mutagenicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81032434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=A+guide+for+performing+germ+cell+mutagenesis+assays+using+Drosophila+melanogaster.&rft.au=Mason%2C+J+M%3BAaron%2C+C+S%3BLee%2C+W+R%3BSmith%2C+P+D%3BThakar%2C+A%3BValencia%2C+R%3BWoodruff%2C+R+C%3BW%C3%BCrgler%2C+F+E%3BZimmering%2C+S&rft.aulast=Mason&rft.aufirst=J&rft.date=1987-10-01&rft.volume=189&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-10-30 N1 - Date created - 1987-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nucleotide sequence analysis of Tn4551: use of ermFS operon fusions to detect promoter activity in Bacteroides fragilis. AN - 81031570; 2820936 AB - The Bacteroides pBI136 clindamycin resistance (Ccr) determinant from the composite transposon Tn4551 was cloned onto the shuttle plasmid pFD160, and the regions necessary for expression in Bacteroides fragilis were determined. These results suggested that transcriptional regulatory signals required for Ccr were located in the Tn4551 direct repeat sequence (DRS) adjacent to the resistance determinant. Analysis of the nucleotide sequence of this region revealed that the Ccr structural gene, 798 base pairs (bp), was located 17 bp from the terminus of the DRS and that this gene (ermFS) differed from ermF (pBF4) by one amino acid. The DRS element was found to be 1,155 bp and appeared to contain the ermFS transcription start signals. The DRS structure was typical of insertion sequence elements isolated from other bacterial species, and its termini were characterized by 25-bp regions of imperfect dyad symmetry. The DRS was dominated by a 978-bp open reading frame, which terminated in the left inverted repeat 27 bp from the ermFS start codon, and weak amino acid sequence homology was observed with the putative transposase of IS3. Promoter activity of the DRS in B. fragilis was demonstrated by in vitro construction of operon fusions with a promoterless ermFS gene followed by transformation of the recombinant plasmids with selection for resistance to clindamycin. The location of one DRS promoter was identified by using the ermFS fusions and then verified by in vitro mutagenesis of the site with single-stranded linkers. Northern blot (RNA blot) analysis of total RNA from B. fragilis strains containing pBI136 or ermFS recombinant plasmids confirmed the location of this promoter and indicated that it was used in vivo by Tn4551. A second DRS promoter, which activated ermFS transcription by readthrough of the large DRS open reading frame, was also identified by the Northern blot analysis. The bicistronic ermFS message was not observed in strains containing a complete copy of Tn4551, and the possibility of transcriptional regulation is discussed. JF - Journal of bacteriology AU - Smith, C J AD - Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Frederick, Maryland 21701. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 4589 EP - 4596 VL - 169 IS - 10 SN - 0021-9193, 0021-9193 KW - DNA Transposable Elements KW - 0 KW - DNA, Bacterial KW - Clindamycin KW - 3U02EL437C KW - DNA Restriction Enzymes KW - EC 3.1.21.- KW - Index Medicus KW - Transformation, Bacterial KW - Sequence Homology, Nucleic Acid KW - Operon KW - Drug Resistance, Microbial KW - Amino Acid Sequence KW - DNA, Bacterial -- analysis KW - Plasmids KW - Cloning, Molecular KW - Base Sequence KW - Genes KW - Molecular Sequence Data KW - Repetitive Sequences, Nucleic Acid KW - Promoter Regions, Genetic KW - Genes, Bacterial KW - Bacteroides fragilis -- drug effects KW - Clindamycin -- pharmacology KW - Bacteroides fragilis -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81031570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Nucleotide+sequence+analysis+of+Tn4551%3A+use+of+ermFS+operon+fusions+to+detect+promoter+activity+in+Bacteroides+fragilis.&rft.au=Smith%2C+C+J&rft.aulast=Smith&rft.aufirst=C&rft.date=1987-10-01&rft.volume=169&rft.issue=10&rft.spage=4589&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-05 N1 - Date created - 1987-11-05 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - M17808; GENBANK N1 - SuppNotes - Cited By: J Bacteriol. 1981 Apr;146(1):415-7 [6260746] J Bacteriol. 1987 Aug;169(8):3450-7 [3038840] Nucleic Acids Res. 1982 Jan 11;10(1):31-8 [6278408] Annu Rev Genet. 1981;15:341-404 [6279020] J Bacteriol. 1982 Aug;151(2):686-91 [7096266] Nucleic Acids Res. 1982 Oct 11;10(19):5935-48 [6292860] Cell. 1983 Mar;32(3):809-16 [6187472] Cell. 1983 Apr;32(4):1337-46 [6188537] J Mol Biol. 1983 Jun 5;166(4):557-80 [6345791] Gene. 1983 Dec;26(1):101-6 [6323249] J Bacteriol. 1984 May;158(2):739-41 [6725207] Gene. 1984 Jun;28(3):351-9 [6235151] Plasmid. 1984 May;11(3):248-52 [6379711] Plasmid. 1984 May;11(3):268-71 [6087395] Proc Natl Acad Sci U S A. 1984 Nov;81(22):7203-6 [6095273] J Bacteriol. 1985 Mar;161(3):1069-73 [2982783] Gene. 1985;33(1):103-19 [2985470] J Bacteriol. 1985 May;162(2):626-32 [2985540] Nucleic Acids Res. 1985 Mar 25;13(6):2127-39 [2987844] Proc Natl Acad Sci U S A. 1985 Jun;82(12):4202-6 [3889924] Plasmid. 1985 May;13(3):182-92 [2987997] J Bacteriol. 1985 Oct;164(1):230-6 [2413007] J Bacteriol. 1985 Oct;164(1):294-301 [2995313] J Bacteriol. 1985 Oct;164(1):466-9 [4044530] Gene. 1985;37(1-3):111-23 [3902569] Proc Natl Acad Sci U S A. 1967 May;57(5):1514-21 [5231757] J Bacteriol. 1973 Nov;116(2):1064-6 [4583233] Proc Natl Acad Sci U S A. 1974 Apr;71(4):1342-6 [4598299] J Mol Biol. 1975 Nov 5;98(3):503-17 [1195397] Anal Biochem. 1976 Dec;76(2):431-41 [11708] J Mol Biol. 1977 Jun 15;113(1):237-51 [881736] J Bacteriol. 1985 Dec;164(3):1248-55 [2999075] J Bacteriol. 1986 Mar;165(3):929-36 [3005243] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] Annu Rev Biochem. 1978;47:967-96 [354508] J Infect Dis. 1979 Jan;139(1):97-101 [108340] Nucleic Acids Res. 1979 Mar;6(3):1111-22 [375194] Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 [388356] Annu Rev Genet. 1979;13:319-53 [94251] Anal Biochem. 1979 Sep 15;98(1):60-3 [120689] J Bacteriol. 1981 Feb;145(2):867-72 [6257654] Plasmid. 1986 Jan;15(1):8-18 [3006107] J Bacteriol. 1986 Aug;167(2):517-21 [3015877] J Bacteriol. 1986 Nov;168(2):523-33 [3023281] Nucleic Acids Res. 1981 Jun 25;9(12):2905-11 [6269064] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Assessment of the permeability of the blood-retinal barrier in hypertensive rats. AN - 81024172; 3653967 AB - We assessed the permeability surface area products at the blood-retinal barrier and blood-brain barrier to sucrose (molecular weight, 340) and microperoxidase (molecular weight, 2000) following acute hypertension induced by metaraminol in Wistar-Kyoto rats (controls) and during chronic hypertension in spontaneously hypertensive rats. In acute hypertension, the permeability surface area product for sucrose was increased at the blood-retinal barrier and at the blood-brain barrier over control values (p less than 0.02), and the vessels became leaky to microperoxidase. In chronic hypertension, the permeability of the blood-retinal barrier to sucrose was increased over that in control animals (p less than 0.02), whereas the permeability of the blood-brain barrier was unaffected. Neither barrier leaked microperoxidase. These results indicate that the blood-brain barrier and the blood-retinal barrier are similarly affected in acute hypertension and that in chronic hypertension, the blood-brain barrier is unaffected whereas the blood-retinal barrier is rendered more permeable to small, but not large, solutes. JF - Hypertension (Dallas, Tex. : 1979) AU - Lightman, S AU - Rechthand, E AU - Latker, C AU - Palestine, A AU - Rapoport, S AD - Laboratory of Immunology, National Eye Institute, Bethesda, Maryland. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 390 EP - 395 VL - 10 IS - 4 SN - 0194-911X, 0194-911X KW - Sucrose KW - 57-50-1 KW - Metaraminol KW - 818U2PZ2EH KW - Peroxidases KW - EC 1.11.1.- KW - microperoxidase KW - Index Medicus KW - Rats KW - Acute Disease KW - Permeability KW - Animals KW - Rats, Inbred WKY KW - Rats, Inbred SHR KW - Chronic Disease KW - Peroxidases -- pharmacokinetics KW - Sucrose -- pharmacokinetics KW - Blood-Brain Barrier KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology KW - Hypertension -- genetics KW - Blood-Retinal Barrier UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81024172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Assessment+of+the+permeability+of+the+blood-retinal+barrier+in+hypertensive+rats.&rft.au=Lightman%2C+S%3BRechthand%2C+E%3BLatker%2C+C%3BPalestine%2C+A%3BRapoport%2C+S&rft.aulast=Lightman&rft.aufirst=S&rft.date=1987-10-01&rft.volume=10&rft.issue=4&rft.spage=390&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=0194911X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-16 N1 - Date created - 1987-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biochemistry of azacitidine: a review. AN - 81008955; 2443243 AB - Azacitidine is a pyrimidine ring analog of cytidine that is incorporated into RNA causing alteration in RNA synthesis and processing and resulting in inhibition of protein synthesis. Azacitidine as the deoxynucleotide is also incorporated into DNA inhibiting its synthesis and blocking cytosine methylation by noncompetitive inhibition of DNA methyltransferase. The resulting hypomethylation of DNA is thought to induce gene activation and expression and cell differentiation. This may be an underlying factor in azacitidine's antileukemic activity and also contributes to its carcinogenic and tumor-promoting properties in experimental models. JF - Cancer treatment reports AU - Glover, A B AU - Leyland-Jones, B AD - Investigational Drug Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 959 EP - 964 VL - 71 IS - 10 SN - 0361-5960, 0361-5960 KW - RNA KW - 63231-63-0 KW - DNA KW - 9007-49-2 KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Animals KW - Biochemistry KW - RNA -- metabolism KW - Leukemia -- metabolism KW - Biochemical Phenomena KW - Humans KW - DNA -- metabolism KW - Gene Expression Regulation -- drug effects KW - Cell Differentiation -- drug effects KW - Transcriptional Activation KW - Azacitidine -- pharmacology KW - Azacitidine -- pharmacokinetics KW - Azacitidine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81008955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+treatment+reports&rft.atitle=Biochemistry+of+azacitidine%3A+a+review.&rft.au=Glover%2C+A+B%3BLeyland-Jones%2C+B&rft.aulast=Glover&rft.aufirst=A&rft.date=1987-10-01&rft.volume=71&rft.issue=10&rft.spage=959&rft.isbn=&rft.btitle=&rft.title=Cancer+treatment+reports&rft.issn=03615960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-12 N1 - Date created - 1987-11-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Practical considerations in establishing valid and sensitive neurobehavioral test methods. AN - 77924156; 3124371 AB - Validity and Sensitivity are discussed as key concepts for the Evaluation of neurobehavioral tests; validity refers to the meaning of an observed behavioral change, and sensitivity to the capability of a test to detect behavioral changes relative to dose and/or to other tests. Examples are given to explain these concepts. It is proposed to validate tests by means of compounds with known neurotoxic properties, and to cover sensitivity by described dose-response characteristics. JF - Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. Serie B, Umwelthygiene, Krankenhaushygiene, Arbeitshygiene, praventive Medizin AU - Tilson, H A AD - Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 10 EP - 15 VL - 185 IS - 1-2 SN - 0932-6073, 0932-6073 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Predictive Value of Tests KW - Behavior, Animal -- drug effects KW - Drug Evaluation, Preclinical -- standards KW - Drug-Related Side Effects and Adverse Reactions KW - Nervous System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77924156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zentralblatt+fur+Bakteriologie%2C+Mikrobiologie+und+Hygiene.+Serie+B%2C+Umwelthygiene%2C+Krankenhaushygiene%2C+Arbeitshygiene%2C+praventive+Medizin&rft.atitle=Practical+considerations+in+establishing+valid+and+sensitive+neurobehavioral+test+methods.&rft.au=Tilson%2C+H+A&rft.aulast=Tilson&rft.aufirst=H&rft.date=1987-10-01&rft.volume=185&rft.issue=1-2&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Zentralblatt+fur+Bakteriologie%2C+Mikrobiologie+und+Hygiene.+Serie+B%2C+Umwelthygiene%2C+Krankenhaushygiene%2C+Arbeitshygiene%2C+praventive+Medizin&rft.issn=09326073&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-11 N1 - Date created - 1988-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phorbol ester- and light-induced endogenous phosphorylation of rat rod outer-segment proteins. AN - 77898520; 3428384 AB - We have previously described the presence of a C-kinase in bovine retinal rod outer segments (ROS) (Kapoor and Chader, 1984). In this study, we have labeled rat retinas with freshly neutralized radiolabeled sodium phosphate (32P or 33P) by intravitreal injection and compared the phosphorylation patterns of ROS proteins induced by light and specific activators of the C-kinase phosphorylation system. Except for light treatment, all procedures were carried out in complete darkness using an infrared image converter. Incubation of 33P-labeled retinas in light for 5 min resulted in the phosphorylation of rhodopsin, 80-, 65-, 47-, 44-, and 15,000 MW proteins of crude ROS. Incubation of 33P-labeled retinas with 0.5 microM 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in the phosphorylation of several proteins including those at 80-, 65-, 47-, 44-, and 15,000 MW in crude ROS. ROS prepared in complete darkness did not exhibit any phosphorylation of proteins whereas ROS prepared in red light exhibited variable low phosphorylation of 80-, 47-, 44- and 15,000 MW proteins. 1-oleoyl-2-acetylglycerol (OAG) at 500 micrograms ml-1 caused the phosphorylation of the same proteins as observed with TPA. TPA (0.5-500 microM) and OAG (150-500 micrograms ml-1) did not induce rhodopsin phosphorylation. When purified ROS were prepared from 33P-pre-labeled retinas, the complete darkness control did not exhibit phosphorylation of any proteins. TPA, however, induced the phosphorylation of 80- and 65,000 MW proteins and light induced the phosphorylation of 80-, 65,000 MW proteins as well as opsin monomer and dimer. Affinity chromatography of phosphorylated ROS proteins on con A-Sepharose revealed that TPA does not induce rhodopsin phosphorylation whereas light does. Since light and TPA induced the phosphorylation of 80- and 65,000 MW proteins in ROS, it is possible to suggest at least a partial linkage of light- and C-kinase-mediated effects in situ. JF - Experimental eye research AU - Kapoor, C L AU - O'Brien, P J AU - Chader, G J AD - Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, Bethesda, MD 20892. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 545 EP - 556 VL - 45 IS - 4 SN - 0014-4835, 0014-4835 KW - Diglycerides KW - 0 KW - Eye Proteins KW - Phosphates KW - 1-oleoyl-2-acetylglycerol KW - 86390-77-4 KW - Rhodopsin KW - 9009-81-8 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - sodium phosphate KW - SE337SVY37 KW - Index Medicus KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - Enzyme Activation KW - Molecular Weight KW - Phosphates -- metabolism KW - Rats KW - Rats, Inbred Strains KW - Dark Adaptation KW - Diglycerides -- pharmacology KW - Phosphorylation KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Light KW - Rhodopsin -- metabolism KW - Protein Kinase C -- metabolism KW - Rod Cell Outer Segment -- metabolism KW - Eye Proteins -- metabolism KW - Rod Cell Outer Segment -- enzymology KW - Photoreceptor Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77898520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+eye+research&rft.atitle=Phorbol+ester-+and+light-induced+endogenous+phosphorylation+of+rat+rod+outer-segment+proteins.&rft.au=Kapoor%2C+C+L%3BO%27Brien%2C+P+J%3BChader%2C+G+J&rft.aulast=Kapoor&rft.aufirst=C&rft.date=1987-10-01&rft.volume=45&rft.issue=4&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Experimental+eye+research&rft.issn=00144835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-03 N1 - Date created - 1988-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dysplastic nevi, melanoma and sunlight. AN - 77887185; 3697344 JF - Photo-dermatology AU - Kraemer, K H AD - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 227 EP - 229 VL - 4 IS - 5 SN - 0108-9684, 0108-9684 KW - Index Medicus KW - Genes, Dominant KW - Risk Factors KW - Humans KW - Skin Neoplasms -- genetics KW - Nevus, Pigmented -- genetics KW - Nevus, Pigmented -- complications KW - Sunlight -- adverse effects KW - Skin Neoplasms -- etiology KW - Melanoma -- etiology KW - Nevus, Pigmented -- etiology KW - Melanoma -- complications KW - Skin Neoplasms -- complications KW - Skin Neoplasms -- classification KW - Nevus, Pigmented -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77887185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photo-dermatology&rft.atitle=Dysplastic+nevi%2C+melanoma+and+sunlight.&rft.au=Kraemer%2C+K+H&rft.aulast=Kraemer&rft.aufirst=K&rft.date=1987-10-01&rft.volume=4&rft.issue=5&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Photo-dermatology&rft.issn=01089684&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-16 N1 - Date created - 1988-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Methyl isocyanate: a review of health effects research since Bhopal. AN - 77884476; 3319745 JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Bucher, J R AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 367 EP - 379 VL - 9 IS - 3 SN - 0272-0590, 0272-0590 KW - Cyanates KW - 0 KW - Hemoglobins KW - Isocyanates KW - Mutagens KW - methyl isocyanate KW - C588JJ4BV9 KW - Index Medicus KW - Hemoglobins -- drug effects KW - Animals KW - Reproduction -- drug effects KW - Humans KW - Disasters KW - India KW - Environmental Exposure KW - Lung -- drug effects KW - Follow-Up Studies KW - Immunity -- drug effects KW - Accidents, Occupational KW - Chemical Industry KW - Cyanates -- toxicity KW - Cyanates -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77884476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Methyl+isocyanate%3A+a+review+of+health+effects+research+since+Bhopal.&rft.au=Bucher%2C+J+R&rft.aulast=Bucher&rft.aufirst=J&rft.date=1987-10-01&rft.volume=9&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neutrophils are hyperpolarized after exudation and show an increased depolarization response to formyl-peptide but not to phorbol myristate acetate. AN - 77878971; 3121348 AB - The migration of polymorphonuclear leucocytes (PMN) to extravascular sites and the interaction with chemotactic substances at such locations is called exudation. Since stimulation of PMN in vitro modifies the characteristics of PMN, we asked the question whether similar modifications take place during in-vivo exudation. We found that resting guinea-pig peritoneal exudate PMN were hyperpolarized in comparison to blood PMN of the same species. Guinea-pig and human exudate PMN responded to lower N-formyl-methionylleucylphenylalanine (fmet-leu-phe) concentrations than blood PMN and exhibited a larger membrane depolarization. Furthermore, experiments with the fluorescence-activated cell sorter revealed increased forward light scatter from resting exudate PMN compared to blood PMN. Experiments with the fluorescence-activated cell sorter using the fluoresceinated ligand fmet-leu-phe-lysin-fluorescein (fmet-leu-phe-lys-F) indicated that the priming of exudate PMN was associated with increased fmet-leu-phe-lys-F binding on the individual cells. In contrast, phorbol myristate acetate (PMA) did not induce an increased membrane depolarization response in human and guinea-pig exudate PMN. With this stimulus, the only sign of priming was the shorter activation time in exudate PMN compared to blood PMN. Thus, in-vivo exudation modifies the characteristics of resting and stimulated PMN. The priming is different for different stimuli. Increased responsiveness to fmet-leu-phe may be due to fmet-leu-phe receptor upregulation. The distinct characteristics of exudate PMN that we describe may allow definition of clinical situations in which PMN are primed in vivo. JF - European journal of clinical investigation AU - Zimmerli, W AU - Seligmann, B E AU - Gallin, J I AD - Bacterial Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 435 EP - 441 VL - 17 IS - 5 SN - 0014-2972, 0014-2972 KW - Indicators and Reagents KW - 0 KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Fluorescence KW - Guinea Pigs KW - Humans KW - In Vitro Techniques KW - Membrane Potentials -- drug effects KW - Female KW - Neutrophils -- metabolism KW - Neutrophils -- drug effects KW - N-Formylmethionine Leucyl-Phenylalanine -- pharmacology KW - Exudates and Transudates -- cytology KW - Tetradecanoylphorbol Acetate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77878971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+clinical+investigation&rft.atitle=Neutrophils+are+hyperpolarized+after+exudation+and+show+an+increased+depolarization+response+to+formyl-peptide+but+not+to+phorbol+myristate+acetate.&rft.au=Zimmerli%2C+W%3BSeligmann%2C+B+E%3BGallin%2C+J+I&rft.aulast=Zimmerli&rft.aufirst=W&rft.date=1987-10-01&rft.volume=17&rft.issue=5&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=European+journal+of+clinical+investigation&rft.issn=00142972&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-08 N1 - Date created - 1988-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative results of 327 chemical carcinogenicity studies. AN - 77878173; 3691430 AB - The National Cancer Institute (NCI) and the National Toxicology Program (NTP) have carried out a number of laboratory animal carcinogenicity studies and presented the results of these experiments in a series of Technical Reports. This paper tabulates the results of the 327 NCI/NTP studies carried out to date on 308 distinct chemicals, and discusses certain issues relevant to the evaluation of carcinogenicity in these experiments. This compilation of results from NCI/NTP carcinogenicity experiments provides a large database that can be used to study structure-activity correlations, interspecies concordance, and associations between laboratory animal carcinogenicity and other toxicological effects. JF - Environmental health perspectives AU - Haseman, J K AU - Huff, J E AU - Zeiger, E AU - McConnell, E E AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 229 EP - 235 VL - 74 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Index Medicus KW - United States KW - Rats KW - Animals KW - National Institutes of Health (U.S.) KW - Mice KW - Male KW - Female KW - Mutagenicity Tests KW - Neoplasms, Experimental -- chemically induced KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77878173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Comparative+results+of+327+chemical+carcinogenicity+studies.&rft.au=Haseman%2C+J+K%3BHuff%2C+J+E%3BZeiger%2C+E%3BMcConnell%2C+E+E&rft.aulast=Haseman&rft.aufirst=J&rft.date=1987-10-01&rft.volume=74&rft.issue=&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-17 N1 - Date created - 1988-02-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 1980 Mar;41(3):454-68 [7387835] IARC Sci Publ. 1980;(27):259-81 [6893701] J Toxicol Environ Health. 1981 Jul-Aug;8(1-2):251-80 [7328708] Fundam Appl Toxicol. 1983 Nov-Dec;3(6):631-9 [6662305] Prog Clin Biol Res. 1984;141:43-64 [6718388] Arch Toxicol Suppl. 1987;10:10-26 [3555413] Drug Metab Rev. 1984;15(5-6):1251-73 [6525963] Environ Health Perspect. 1984 Dec;58:385-92 [6525993] Environ Health Perspect. 1984 Dec;58:9-319 [6525996] Environ Health Perspect. 1986 Aug;67:161-200 [3530736] J Toxicol Environ Health. 1984;14(5-6):621-39 [6520881] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Behavioral and psychophysiological markers of disordered attention. AN - 77878129; 3319553 AB - Behavioral and psychophysiological assays provide the most sensitive indication of whether a presumed neurotoxin has a deleterious effect on the nervous system. The effects of lead on the nervous system are strongly suggestive that this agent can produce disturbances in attention; moreover, there are clinical reports of such effects. The action of lead is also manifest in behaviors described as "hyperactive," or reflecting "minimal brain damage." The core symptom in both disorders is probably impairment in attention. The recent Diagnostic and Statistical Manual (DSM-III) of the American Psychiatric Association uses the term Attention Deficit Disorder to replace such terms as hyperactivity and minimal brain damage. Prior studies of the behavioral toxicity of lead may have used inadequate or incomplete assays of attention; this could in part account for the variability in outcomes. Recent research on attention suggests that it is a complex behavior consisting of a number of elements or components, each of which may be in part dependent upon a different region of the central nervous system. Behavioral assays should examine the components of attentive behavior using tests which are sensitive to the different elements. It is recommended that psychophysiological assays (using cognitive event-related potentials), although more difficult and costly to implement, be used as well. These assays may provide a more dynamic view of altered information processing in the brain and help to localize and characterize the behavioral impairment. JF - Environmental health perspectives AU - Mirsky, A F AD - Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, MD 20892. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 191 EP - 199 VL - 74 SN - 0091-6765, 0091-6765 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Evoked Potentials -- drug effects KW - Behavior -- drug effects KW - Animals KW - Psychophysiology KW - Humans KW - Attention -- drug effects KW - Environmental Pollutants -- adverse effects KW - Attention Deficit Disorder with Hyperactivity -- psychology KW - Attention Deficit Disorder with Hyperactivity -- diagnosis KW - Attention Deficit Disorder with Hyperactivity -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77878129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Behavioral+and+psychophysiological+markers+of+disordered+attention.&rft.au=Mirsky%2C+A+F&rft.aulast=Mirsky&rft.aufirst=A&rft.date=1987-10-01&rft.volume=74&rft.issue=&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-17 N1 - Date created - 1988-02-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Ital Biol. 1965 Dec 10;103(4):847-82 [5325947] Electroencephalogr Clin Neurophysiol. 1965 Mar;18:334-48 [14267826] N Engl J Med. 1979 Mar 29;300(13):689-95 [763299] Dev Psychobiol. 1979 Jul;12(4):369-79 [110638] Science. 1980 Nov 14;210(4471):803-5 [7434000] Neurology. 1982 Jul;32(7):776-8 [7201116] Biol Psychol. 1982 Feb-Mar;14(1-2):1-52 [6809064] Electroencephalogr Clin Neurophysiol. 1983 Aug;56(2):169-85 [6191948] Schizophr Bull. 1984;10(2):160-203 [6729409] Science. 1984 Sep 28;225(4669):1493-6 [6474187] J Autism Dev Disord. 1985 Mar;15(1):55-76 [3980430] Psychiatry Res. 1986 Jun;18(2):161-77 [3814238] Adv Psychosom Med. 1987;17:167-84 [3296690] Environ Health Perspect. 1987 Oct;74:153-68 [3319550] Environ Health Perspect. 1987 Oct;74:169-75 [3319551] Environ Health Perspect. 1987 Oct;74:177-84 [2826119] J Consult Psychol. 1956 Oct;20(5):343-50 [13367264] Exp Neurol. 1960 Feb;2:75-89 [14422879] J Nerv Ment Dis. 1959 Sep;129:257-62 [14437233] Exp Neurol. 1964 Jun;9:463-9 [14188533] J Appl Physiol. 1969 Aug;27(2):296-300 [5796327] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The mouse bioassay for the detection of estrogenic activity in rodent diets: I. A standardized method for conducting the mouse bioassay. AN - 77873055; 3695393 AB - A standardized procedure was developed for conducting the mouse bioassay for detecting estrogenic activity in rodent diets. Studies were conducted with CD-1 mice to determine the appropriate weaning age and length of bioassay period. Uterine growth curves were generated from mice weaned at 15 days of age and fed a negative control diet until 28 days of age. These mice showed slow regular increases in uterine weights from 15 22 days of age followed by rapid uterine growth in some mice from 24 to 28 days of age. Estrogenic bioassays using female mice weaned at 15 days of age and fed the positive control diets containing 4 or 6 ppb diethylstilbestrol (DES) demonstrated significant (P less than 0.05) increases in uterine weight and in uterus to body weight (U:BW) ratios over those of mice fed the negative control diet without DES for 5, 7 or 9 days after weaning. In contrast, mice weaned at 17 days of age showed significant (P less than 0.05) increases in uterine weight and in U:BW ratios only at 5 days after weaning. Six ppb DES was required in the positive control diet to produce a 1.5 fold increase in the U:BW ratio over those of mice fed the negative control diet. It was concluded that mice should be weaned at 15 days of age and that the bioassay period should be terminated at 7 days, when the mice are 22 days old, for best reproducible results. The criteria for a valid bioassay should include the demonstration of a significant statistical increase in the U:BW ratios of mice fed the DES positive diet over those of mice fed the negative control diet. JF - Laboratory animal science AU - Thigpen, J E AU - Li, L A AU - Richter, C B AU - Lebetkin, E H AU - Jameson, C W AD - National Institute of Environmental Health Sciences, Comparative Medicine Branch, Research Triangle Park, NC 27709. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 596 EP - 601 VL - 37 IS - 5 SN - 0023-6764, 0023-6764 KW - Estrogens KW - 0 KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Diethylstilbestrol -- analysis KW - Aging KW - Diethylstilbestrol -- pharmacology KW - Biological Assay KW - Mice KW - Rodentia KW - Female KW - Organ Size -- drug effects KW - Uterus -- growth & development KW - Animal Feed KW - Estrogens -- pharmacology KW - Estrogens -- analysis KW - Uterus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77873055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+animal+science&rft.atitle=The+mouse+bioassay+for+the+detection+of+estrogenic+activity+in+rodent+diets%3A+I.+A+standardized+method+for+conducting+the+mouse+bioassay.&rft.au=Thigpen%2C+J+E%3BLi%2C+L+A%3BRichter%2C+C+B%3BLebetkin%2C+E+H%3BJameson%2C+C+W&rft.aulast=Thigpen&rft.aufirst=J&rft.date=1987-10-01&rft.volume=37&rft.issue=5&rft.spage=596&rft.isbn=&rft.btitle=&rft.title=Laboratory+animal+science&rft.issn=00236764&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-29 N1 - Date created - 1988-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Subchronic toxicity of propantheline bromide administered in the feed to Fischer 344/N rats and B6C3F1 mice. AN - 77861864; 3692008 AB - Propantheline bromide, a drug used for the treatment of peptic ulcers, was studied in male and female Fischer 344/N rats and B6C3F1 mice for subchronic toxicity. The drug was administered in the feed for 13 weeks at 0, 220, 670, 2000, 6000, and 24,000 ppm in both species. Propantheline bromide caused a decrease in weight gain at 24,000 ppm in male and female rats and at 6000 and 24,000 ppm in male and female mice. All rats survived the treatment. The top dose of 24,000 ppm was fatal to mice. Clinical signs of toxicity (dilated pupils and decreased gastrointestinal emptying), similar to the atropine-like effects of propantheline bromide in man, were seen in male and female rats at 24,000 ppm. Hyperplasia of the transitional epithelium of the urinary bladder was seen in high-dose male rats at the end of 13 weeks. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Dunnick, J K AU - Jameson, C W AU - Montgomery, C A AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 496 EP - 503 VL - 9 IS - 3 SN - 0272-0590, 0272-0590 KW - Propantheline KW - 1306V2B0Q8 KW - Index Medicus KW - Urinary Bladder -- pathology KW - Administration, Oral KW - Animals KW - Sex Factors KW - Dose-Response Relationship, Drug KW - Random Allocation KW - Mice KW - Urinary Bladder -- drug effects KW - Rats KW - Hyperplasia -- chemically induced KW - Rats, Inbred F344 KW - Body Weight -- drug effects KW - Female KW - Male KW - Propantheline -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77861864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Subchronic+toxicity+of+propantheline+bromide+administered+in+the+feed+to+Fischer+344%2FN+rats+and+B6C3F1+mice.&rft.au=Dunnick%2C+J+K%3BJameson%2C+C+W%3BMontgomery%2C+C+A&rft.aulast=Dunnick&rft.aufirst=J&rft.date=1987-10-01&rft.volume=9&rft.issue=3&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ethyl acrylate distribution, macromolecular binding, excretion, and metabolism in male Fisher 344 rats. AN - 77861813; 3691998 AB - We have demonstrated previously that ethyl acrylate causes severe acute forestomach (nonglandular portion of the stomach) toxicity in rats. Ethyl acrylate was also shown to cause forestomach tumors when administered to rats chronically by gavage. The current studies were designed to investigate ethyl acrylate distribution, excretion, and metabolism, as well as the macromolecular interactions of ethyl acrylate (EtAc) in the forestomach (target organ) and liver (nontarget organ). 2,3-[14C]Ethyl acrylate was administered in corn oil at 100, 200, or 400 mg/kg by gavage. Data presented here show that the radioactivity derived from EtAc is rapidly absorbed after gavage administration and distributed into all major tissues of male F344 rats. The highest concentration of EtAc-derived radioactivity was detected in the forestomach, glandular stomach, intestine, liver, and kidney at 4 and 24 hr after dosing. The highest percentage of EtAc-derived radioactivity was found in the lipid fraction of the liver. In the forestomach, the highest percentage of EtAc-derived radioactivity was found in the protein fraction. The major route of EtAc excretion was CO2 exhalation (approximately 70% of the administered dose in 24 hr) followed by the urinary excretion. Two metabolites were identified in the urine, namely, N-acetyl-s-(2-carboxyethyl)cysteine and N-acetyl-s-(2-carboxyethyl) cysteine ethyl ester. This suggests that Michael-like addition of sulfhydryls to acrylate is a pathway of EtAc metabolism. Hydrolysis of the ethyl ester may occur before or after conjugation. Further degradation of the GSH conjugates resulted in the formation of the mercapturic acids detected in the urine of EtAc-treated rats. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Ghanayem, B I AU - Burka, L T AU - Matthews, H B AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 389 EP - 397 VL - 9 IS - 3 SN - 0272-0590, 0272-0590 KW - Acrylates KW - 0 KW - ethyl acrylate KW - 71E6178C9T KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Stomach -- metabolism KW - Biotransformation KW - Liver -- metabolism KW - Intestinal Absorption KW - Tissue Distribution KW - Protein Binding KW - Male KW - Acrylates -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77861813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Ethyl+acrylate+distribution%2C+macromolecular+binding%2C+excretion%2C+and+metabolism+in+male+Fisher+344+rats.&rft.au=Ghanayem%2C+B+I%3BBurka%2C+L+T%3BMatthews%2C+H+B&rft.aulast=Ghanayem&rft.aufirst=B&rft.date=1987-10-01&rft.volume=9&rft.issue=3&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Four-day repeated inhalation and recovery study of methyl isocyanate in F344 rats and B6C3F1 mice. AN - 77858086; 3692007 AB - F344 rats and B6C3F1 mice of both sexes were exposed by inhalation to 0, 1, and 3 ppm methyl isocyanate (MIC) for 4 consecutive days (6 hr/day) followed by a recovery period of 91 days. Five mice and rats/sex/group except the 3 ppm group (5 rats/sex on Day 7 and 2 males on Day 28) were killed on Days 7, 28, 49, and 91 after the exposure and examined histopathologically. Forty-nine of 56 male rats, 51 of 56 female rats, and 1 of 56 male mice in the 3 ppm group died by 28 days; early death animals were also examined histologically. Exposure-related changes occurred in rats and mice of both sexes in the 3 ppm group only. Lesions of the nasal cavity in rats and mice were characterized by regeneration of the olfactory and respiratory epithelia secondary to epithelial erosion. By Day 28 the olfactory and respiratory epithelia in mice appeared normal, while in rats incomplete regeneration of the olfactory epithelium was still present. Regeneration of the respiratory epithelium in the trachea of rats occurred in the 3 ppm group and the epithelium appeared to return to normal by Day 28. Lung lesions in rats consisted of mural and/or intraluminal fibrosis secondary to extensive erosion of the respiratory epithelium in the major bronchi to the terminal bronchioles. Acute inflammation of the small airways, occasional hyaline membranes of alveolar walls, and pulmonary atelectasis were also seen. Alveolar fibrosis was observed in rats found dead from Day 14 on and in male rats killed on Day 28. Atrophy of the thymus and spleen, atrial thrombosis of the heart, and hepatocellular necrosis were frequently seen in rats dying following MIC exposure. The lung lesions in mice were qualitatively similar to those in rats, but were restricted to the major bronchi. Minimal intraluminal or mural fibrosis was still present in mice on Day 91. In a separate study, a single 6-hr exposure of five male rats to 3 ppm MIC was followed by a recovery period of 7 days. The lesions of the respiratory system were essentially the same as those in the 3 ppm group killed on Day 7 after the 4-day repeated exposure of MIC, but the alveolar lesions were more severe. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Mitsumori, K AU - Boorman, G A AU - Gupta, B N AU - Bucher, J R AD - Chemical Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 480 EP - 495 VL - 9 IS - 3 SN - 0272-0590, 0272-0590 KW - Cyanates KW - 0 KW - Isocyanates KW - methyl isocyanate KW - C588JJ4BV9 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Body Weight -- drug effects KW - Lung -- drug effects KW - Nasal Cavity -- drug effects KW - Mice KW - Trachea -- drug effects KW - Administration, Inhalation KW - Male KW - Female KW - Cyanates -- toxicity KW - Cyanates -- administration & dosage KW - Respiratory System -- pathology KW - Respiratory System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77858086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Four-day+repeated+inhalation+and+recovery+study+of+methyl+isocyanate+in+F344+rats+and+B6C3F1+mice.&rft.au=Mitsumori%2C+K%3BBoorman%2C+G+A%3BGupta%2C+B+N%3BBucher%2C+J+R&rft.aulast=Mitsumori&rft.aufirst=K&rft.date=1987-10-01&rft.volume=9&rft.issue=3&rft.spage=480&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparative toxicity and carcinogenicity of two chlorinated paraffins in F344/N rats and B6C3F1 mice. AN - 77857121; 3692005 AB - The toxicity and carcinogenicity of chlorinated paraffins containing C12 with 60% Cl, and C23 with 43% Cl, were assessed in prechronic and 2-year gavage studies using F344/N rats and B6C3F1 mice of both sexes. Single administrations of chlorinated paraffins were nonlethal in rats and mice, but repeated-dose and 2-year studies demonstrated toxic responses that differed with the paraffins. The C23,Cl43% paraffin produced a granulomatous inflammation in the liver of female rats in 13-week studies, while the C12,Cl60% paraffin caused deaths of rats and mice in 16-day studies and marked liver enlargement in 13-week studies. In 2-year studies, the C23,Cl43% paraffin caused hepatic and lymphatic granulomatous inflammation and hyperplasia in both sexes of rats, and was associated with marginal increases in adrenal medullary pheochromocytomas in female rats and hepatocellular neoplasms in female mice and with clear increases in malignant lymphomas in male mice. The C12,Cl60% paraffin caused marked liver enlargement in rats and increased the severity of nephropathy in male rats and the incidence of nephropathy in female rats. C12,Cl60% also caused hepatocellular neoplasms in both sexes of rats and mice: kidney tubular cell adenomas and adenocarcinomas in male rats, thyroid follicular cell neoplasms in female rats and female mice, and a marginal increase in mononuclear cell leukemia in male rats. Thus, the short-chain, heavily chlorinated paraffin appears to have a greater potential for chronic toxicity and carcinogenicity than the longer-chain, lightly chlorinated paraffin. Both paraffins have been reported to be nonmutagenic in bacteria. (National Toxicology Program (1986) Technical Report, NIH Publications 86-2561 and 86-2564). JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Bucher, J R AU - Alison, R H AU - Montgomery, C A AU - Huff, J AU - Haseman, J K AU - Farnell, D AU - Thompson, R AU - Prejean, J D AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 454 EP - 468 VL - 9 IS - 3 SN - 0272-0590, 0272-0590 KW - Carcinogens KW - 0 KW - Hydrocarbons, Chlorinated KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Body Weight -- drug effects KW - Mice KW - Time Factors KW - Species Specificity KW - Male KW - Female KW - Organ Size -- drug effects KW - Hydrocarbons, Chlorinated -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77857121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Comparative+toxicity+and+carcinogenicity+of+two+chlorinated+paraffins+in+F344%2FN+rats+and+B6C3F1+mice.&rft.au=Bucher%2C+J+R%3BAlison%2C+R+H%3BMontgomery%2C+C+A%3BHuff%2C+J%3BHaseman%2C+J+K%3BFarnell%2C+D%3BThompson%2C+R%3BPrejean%2C+J+D&rft.aulast=Bucher&rft.aufirst=J&rft.date=1987-10-01&rft.volume=9&rft.issue=3&rft.spage=454&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-20 N1 - Date created - 1988-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A review of approaches to the detection of genetic damage in the human fetus. AN - 77853156; 3319546 AB - Studies in experimental animals suggest links between genetic damage to the fetus and the etiology of several disorders, including fetal loss, teratogenesis, and cancer. Methods for measuring genetic damage directly in the human fetus could provide epidemiologists and clinical researchers with powerful tools for investigating similar associations in humans. Current methods potentially available for such studies include assays for mutagenic substances in human body fluids and for measuring modifications to genetic material at the three levels of organization of genetic material: the chromosome, the gene or specific locus, and chemical DNA. Results of studies using fetal tissues to investigate each of these end points are reviewed, emphasizing studies of chemical modifications to DNA nucleotides detected in the human placenta. JF - Environmental health perspectives AU - Everson, R B AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 109 EP - 117 VL - 74 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Epidemiologic Methods KW - DNA Damage KW - Humans KW - Chromosome Aberrations KW - Female KW - Pregnancy KW - Maternal-Fetal Exchange KW - Smoking -- adverse effects KW - Mutation KW - Neoplasms -- genetics KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77853156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=A+review+of+approaches+to+the+detection+of+genetic+damage+in+the+human+fetus.&rft.au=Everson%2C+R+B&rft.aulast=Everson&rft.aufirst=R&rft.date=1987-10-01&rft.volume=74&rft.issue=&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-17 N1 - Date created - 1988-02-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1985 Jul 25-31;316(6026):369-71 [2991767] Mutagenesis. 1986 May;1(3):195-200 [3331659] Science. 1986 Jan 3;231(4733):54-7 [3941892] Mutat Res. 1986 Jan-Feb;169(1-2):11-6 [3511362] Mutat Res. 1986 May;174(1):27-33 [3702904] Proc Natl Acad Sci U S A. 1986 Jul;83(14):5301-5 [3460092] N Engl J Med. 1971 Apr 15;284(15):878-81 [5549830] N Engl J Med. 1971 Aug 12;285(7):390-2 [5556578] Am J Obstet Gynecol. 1977 May 1;128(1):43-50 [851158] Proc Natl Acad Sci U S A. 1977 Aug;74(8):3555-9 [333441] Mutat Res. 1979 Jul;61(2):353-79 [384224] Mutat Res. 1980 Jun;78(2):209-12 [7393248] Lancet. 1980 Jul 19;2(8186):123-7 [6105296] Mutat Res. 1981 Sep;83(2):291-9 [7300851] Proc Natl Acad Sci U S A. 1981 Oct;78(10):6126-9 [7031643] Cancer Res. 1982 Mar;42(3):893-6 [7059988] Hum Genet. 1981;59(4):389-91 [7333593] Mutat Res. 1982 Apr;97(2):139-46 [6210844] J Chronic Dis. 1982;35(7):581-600 [6282919] Mutat Res. 1982 May;98(3):319-74 [7050697] Cancer Res. 1982 Dec;42(12):5240-5 [7139628] Proc Natl Acad Sci U S A. 1982 Nov;79(21):6617-21 [6983072] Nature. 1983 Mar 10;302(5904):155-6 [6828165] Mutat Res. 1983 Jul;121(1):25-32 [6306458] Am J Public Health. 1983 Oct;73(10):1154-6 [6614268] Mutat Res. 1983 Sep;121(3-4):241-6 [6621586] Carcinogenesis. 1984 Mar;5(3):373-7 [6423306] Adv Exp Med Biol. 1984;176:13-49 [6388255] Environ Mutagen. 1984;6(6):879-87 [6389112] Mutat Res. 1984 Dec;130(6):395-401 [6083450] Lancet. 1985 Feb 9;1(8424):312-5 [2857366] Environ Mutagen. 1985;7(2):171-84 [3971957] Prog Nucleic Acid Res Mol Biol. 1984;31:1-58 [6085171] Am J Public Health. 1985 May;75(5):487-92 [3985235] J Immunol. 1985 Jun;134(6):4009-17 [3857280] Mutat Res. 1985 Jun-Jul;150(1-2):411-22 [3873612] Nature. 1985 May 23-29;315(6017):343-5 [4000264] Am J Epidemiol. 1985 Feb;121(2):216-24 [3860001] Carcinogenesis. 1985 Jul;6(7):1067-9 [4017174] Carcinogenesis. 1985 Aug;6(8):1117-26 [3926335] J Occup Med. 1986 Aug;28(8):647-55 [3746486] Mutat Res. 1986 Aug-Sep;171(2-3):71-7 [3528838] Cancer Res. 1986 Nov;46(11):5869-77 [3756927] Am J Epidemiol. 1986 Nov;124(5):768-78 [3766510] Prog Exp Tumor Res. 1987;31:86-103 [3562861] Mutat Res. 1985 Oct;144(2):85-8 [4047075] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intermolecular homologous recombination between transfected sequences in mammalian cells is primarily nonconservative. AN - 77852713; 3683393 AB - Intermolecular recombination in mammalian cells was studied by coinfecting African green monkey cells in culture with two shuttle vector plasmids, each carrying an incomplete but overlapping portion of the gene for neomycin resistance. The region of homology between the two plasmids was about 0.6 kilobases. Recombination between the homology regions could reconstruct the neomycin resistance gene, which was monitored by analysis of progeny plasmids in bacteria. The individual plasmids carried additional markers which, in combination with restriction analysis, allowed the determination of the frequency of formation of the heterodimeric plasmid which would be formed in a conservative recombination reaction between the homologous sequences. Reconstruction of the neomycin resistance gene was readily observed, but only 1 to 2% of the neomycin resistance plasmids had the structure of the conservative heterodimer. Treatment of the plasmids which enhanced the frequency of the neomycin resistance gene reconstruction reaction did not significantly increase the relative frequency of conservative product plasmids. The results support nonconservative models for recombination of these sequences. JF - Molecular and cellular biology AU - Seidman, M M AD - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 3561 EP - 3565 VL - 7 IS - 10 SN - 0270-7306, 0270-7306 KW - Index Medicus KW - Animals KW - DNA Repair KW - Transfection KW - Cercopithecus aethiops KW - Models, Biological KW - DNA Replication KW - Cell Line KW - Recombination, Genetic KW - Plasmids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77852713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Intermolecular+homologous+recombination+between+transfected+sequences+in+mammalian+cells+is+primarily+nonconservative.&rft.au=Seidman%2C+M+M&rft.aulast=Seidman&rft.aufirst=M&rft.date=1987-10-01&rft.volume=7&rft.issue=10&rft.spage=3561&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-19 N1 - Date created - 1988-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1977 Oct;74(10):4168-72 [270661] J Mol Biol. 1967 Jun 14;26(2):365-9 [4291934] Gene. 1980 May;9(3-4):287-305 [6248430] Cell. 1980 Aug;21(1):141-8 [6250709] Science. 1980 Sep 19;209(4463):1392-6 [6251547] Nucleic Acids Res. 1980 Dec 11;8(23):5835-44 [6258154] Cell. 1981 Jan;23(1):175-82 [6260373] Mol Cell Biol. 1982 Nov;2(11):1372-87 [6298598] Virology. 1983 Feb;125(1):175-93 [6299005] Proc Natl Acad Sci U S A. 1983 Apr;80(7):2002-6 [6132383] Mol Cell Biol. 1983 Jun;3(6):1040-52 [6308421] Proc Natl Acad Sci U S A. 1983 Jul;80(14):4417-21 [6308623] Proc Natl Acad Sci U S A. 1983 Aug;80(15):4827-31 [6576360] Proc Natl Acad Sci U S A. 1984 May;81(10):3153-7 [6328502] Mol Cell Biol. 1984 Jun;4(6):1020-34 [6330525] Cell. 1983 May;33(1):25-35 [6380756] Mol Cell Biol. 1985 Jan;5(1):59-69 [2984556] Mol Cell Biol. 1985 May;5(5):1034-42 [2987671] Nature. 1985 Sep 19-25;317(6034):230-4 [2995814] Genetics. 1985 Oct;111(2):375-88 [2996980] Gene. 1985;38(1-3):233-7 [2998945] Cell. 1986 Feb 14;44(3):419-28 [3002636] Proc Natl Acad Sci U S A. 1986 Mar;83(6):1762-6 [3006069] Mol Cell Biol. 1985 Aug;5(8):2080-9 [3018550] Mol Cell Biol. 1986 Jul;6(7):2520-6 [3023937] Mol Cell Biol. 1986 Sep;6(9):3246-52 [3023971] Mol Cell Biol. 1986 Dec;6(12):4295-304 [3025650] J Mol Biol. 1986 Oct 5;191(3):341-54 [3029381] Virology. 1979 Jan 30;92(2):291-8 [218345] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Sleep disturbances due to exposure to tone pulses throughout the night. AN - 77848564; 3685754 AB - Sleep electroencephalograms (EEGs) and subjective reports data were obtained from six subjects (male college students) during 2 nights of baseline observation and 5 experimental nights of exposure to a 90-100 dB, 25 ms, 1,000 c/s tone pulse with various interstimulus intervals. The first of the 5 experimental nights started with an intertone interval of 80 s. On each of the following 4 nights, the intertone interval was fixed at 40-, 10-, 2.5-, or 1-s intervals, respectively. With the intensification of noise stimulus by shortening the intervals of tone pulses, a progressive disruption of nightly EEG sleep patterns was observed as follows: (a) increased frequency of awakenings and sleep stage changes during the night, (b) prolonged sleep latency, and (c) increased percentage of time spent in stage 1 sleep. However, total sleep time, REM latency, inter-REM intervals, and the percentages of time in stages 2, 3, 4, and REM sleep did not change significantly. The degree of subjective sleep disturbance was highly associated with objective measures of nightly EEG sleep patterns. JF - Sleep AU - Nakagawa, Y AD - National Institute of Mental Health, Ichikawa City, Japan. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 463 EP - 472 VL - 10 IS - 5 SN - 0161-8105, 0161-8105 KW - Index Medicus KW - Sleep Stages -- physiology KW - Humans KW - Electroencephalography KW - Adult KW - Acoustic Stimulation KW - Male KW - Sleep Wake Disorders -- etiology KW - Noise -- adverse effects KW - Sleep Wake Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77848564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sleep&rft.atitle=Sleep+disturbances+due+to+exposure+to+tone+pulses+throughout+the+night.&rft.au=Nakagawa%2C+Y&rft.aulast=Nakagawa&rft.aufirst=Y&rft.date=1987-10-01&rft.volume=10&rft.issue=5&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Sleep&rft.issn=01618105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-11 N1 - Date created - 1988-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human cytomegalovirus (HCMV) enhances bovine papilloma virus (BPV) transformation in vitro. AN - 77818528; 2824682 AB - Infection of NIH 3T3 cells with a combination of HCMV and BPV resulted in more foci than infection with BPV alone. Foci were microscopically apparent at 4 days in the mixed infection and did not appear until 2 days later in the cultures infected with BPV alone. The enhancement was abolished by heat inactivation of the HCMV and also when the HCMV was replaced by a "mock inoculum." Southern blot analysis of cellular DNA from transformed cells showed a similar amount of extrachromosomal BPV DNA in cells infected by BPV alone and in cells co-infected with HCMV. No HCMV antigens could be found in these cells by immunofluorescence. The mechanisms of the enhancement are not known. Stimulation of host DNA synthesis by HCMV could possibly increase the transforming efficiency of BPV. Alternatively, the increase in BPV transforming efficiency could be due to a transient increase in BPV-1 transcription by an HCMV transcriptional transactivation factor. Since both HCMV and human papillomaviruses are commonly found in the uterine cervix, HCMV may play a role in human cervical cancer by enhancing the carcinogenic potential of human papillomavirus. JF - Journal of medical virology AU - Goldstein, S C AU - Byrne, J C AU - Rabson, A S AD - Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 157 EP - 164 VL - 23 IS - 2 SN - 0146-6615, 0146-6615 KW - Antigens, Viral KW - 0 KW - DNA, Viral KW - Index Medicus KW - Animals KW - Ultraviolet Rays KW - DNA, Viral -- analysis KW - Humans KW - Nucleic Acid Hybridization KW - Cell Line, Transformed KW - Cell Line KW - Antigens, Viral -- analysis KW - Cytomegalovirus -- physiology KW - Papillomaviridae -- physiology KW - Cytomegalovirus -- immunology KW - Cytomegalovirus -- radiation effects KW - Cytomegalovirus -- genetics KW - Bovine papillomavirus 1 -- physiology KW - Cell Transformation, Viral KW - Bovine papillomavirus 1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77818528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medical+virology&rft.atitle=Human+cytomegalovirus+%28HCMV%29+enhances+bovine+papilloma+virus+%28BPV%29+transformation+in+vitro.&rft.au=Goldstein%2C+S+C%3BByrne%2C+J+C%3BRabson%2C+A+S&rft.aulast=Goldstein&rft.aufirst=S&rft.date=1987-10-01&rft.volume=23&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Journal+of+medical+virology&rft.issn=01466615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-05 N1 - Date created - 1988-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Internalization and cycling of the T cell antigen receptor. Role of protein kinase C. AN - 81017226; 3498715 AB - The dynamics of the T cell antigen receptor on a murine antigen specific T cell hybridoma have been analyzed using a monoclonal anti-receptor antibody. When this antibody, A2B4-2, is bound to surface receptors, no internalization is seen at 4 degrees C. Upon warming to 37 degrees C, between 20 and 30% of the antibody molecules are internalized over 20-30 min as measured by sensitivity to external acid. This level of internalization is identical if monovalent Fab fragments are used. In contrast, cross-linking of the anti-receptor antibody with a second antibody leads to rapid internalization of 100% of prebound surface A2B4-2. Phorbol 12-myristate 13-acetate (PMA) leads to the rapid internalization of up to 65% of the surface A2B4-2 or A2B4-2 Fab fragments. This effect requires protein kinase C and can be completely inhibited by depleting this kinase from the cells by long term treatment with high doses of PMA. Pretreatment of the T cells with PMA leads to a 40-50% drop in surface T cell antigen receptor expression. Despite the loss of surface receptors, the uptake of A2B4-2 in PMA-treated cells at 37 degrees C is identical to that seen in control cells. The total uptake of A2B4-2 at 37 degrees C is 25-30% greater than the number of surface receptors in control cells and about 100-150% greater than the number of surface receptors in PMA-treated cells. At steady state the percentage of total A2B4-2 on the cell surface is 75% for control cells and 38% for PMA-treated cells. The good agreement of these numbers with the percent internalization of a cohort of surface receptors suggests that all receptors are constantly cycling. The effect of PMA is to alter the kinetic parameters of this cycling, thus changing the steady state distribution of receptors between the plasma membrane and internal, presumably endosomal compartments. Measurement of initial rates of internalization suggests that the PMA effect can be largely explained by an increase in the internalization rate constant. JF - The Journal of biological chemistry AU - Minami, Y AU - Samelson, L E AU - Klausner, R D AD - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892. Y1 - 1987/09/25/ PY - 1987 DA - 1987 Sep 25 SP - 13342 EP - 13347 VL - 262 IS - 27 SN - 0021-9258, 0021-9258 KW - Antibodies, Monoclonal KW - 0 KW - Antigen-Antibody Complex KW - Receptors, Antigen, T-Cell KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Cell Membrane -- immunology KW - Phosphorylation KW - Cell Membrane -- drug effects KW - Kinetics KW - Hybridomas -- immunology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Mice KW - T-Lymphocytes -- immunology KW - Protein Kinase C -- metabolism KW - Receptors, Antigen, T-Cell -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81017226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Internalization+and+cycling+of+the+T+cell+antigen+receptor.+Role+of+protein+kinase+C.&rft.au=Minami%2C+Y%3BSamelson%2C+L+E%3BKlausner%2C+R+D&rft.aulast=Minami&rft.aufirst=Y&rft.date=1987-09-25&rft.volume=262&rft.issue=27&rft.spage=13342&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-02 N1 - Date created - 1987-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mapping of a putative genetic locus determining ethanol intake in the mouse. AN - 81108428; 3676756 AB - In the mouse, there is evidence that a single genetic locus is a major determinant of differences in ethanol intake between some preferring and non-preferring inbred strains. In this report, we present evidence from two independent experiments indicating that this locus maps to chromosome 1 and that its expressed product is the abundant protein LTW-4 (a 28 kDa, pI 5.6 protein expressed in brain, liver and kidney). The genetic association was found using a panel of 14 polypeptides of mouse brain which were visualized by two-dimensional electrophoresis and which exhibit genetic variation in isoelectric point. Fifteen BXD recombinant inbred strains and the two parental strains were typed for these loci and also tested for ethanol acceptance. Strains exhibiting the basic allele showed significantly higher ethanol acceptance. When 19 distantly related inbred mouse strains were tested for ethanol acceptance and typed for LTW-4, it was again found that strains exhibiting the basic allele showed significantly higher ethanol acceptance. JF - Brain research AU - Goldman, D AU - Lister, R G AU - Crabbe, J C AD - Laboratory on Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1987/09/15/ PY - 1987 DA - 1987 Sep 15 SP - 220 EP - 226 VL - 420 IS - 2 SN - 0006-8993, 0006-8993 KW - Index Medicus KW - Animals KW - Mice KW - Alcohol Drinking KW - Mice, Inbred Strains -- genetics KW - Alcoholism -- genetics KW - Chromosome Mapping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81108428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Mapping+of+a+putative+genetic+locus+determining+ethanol+intake+in+the+mouse.&rft.au=Goldman%2C+D%3BLister%2C+R+G%3BCrabbe%2C+J+C&rft.aulast=Goldman&rft.aufirst=D&rft.date=1987-09-15&rft.volume=420&rft.issue=2&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-22 N1 - Date created - 1987-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Picking lowest-cost measurements for identifying unknowns. AN - 77914619; 3431130 AB - One way to identify an unknown item is to measure its traits and compare the measurements with those of items the unknown might be. This paper outlines a way to pick what to measure from given known traits to (1) minimize measurement cost and (2) ensure that measuring the picked traits is as good as measuring all the given traits for purposes of identifying unknowns. The paper also relates a computer program which has been written to do this, and the program's use with the Protein Atlas in minimizing the number of amino acids to measure in an experiment involving polypeptide identification. JF - Journal of theoretical biology AU - Olson, A D AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/09/07/ PY - 1987 DA - 1987 Sep 07 SP - 1 EP - 9 VL - 128 IS - 1 SN - 0022-5193, 0022-5193 KW - Peptides KW - 0 KW - Index Medicus KW - Software KW - Information Systems KW - Molecular Sequence Data KW - Amino Acid Sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77914619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+theoretical+biology&rft.atitle=Picking+lowest-cost+measurements+for+identifying+unknowns.&rft.au=Olson%2C+A+D&rft.aulast=Olson&rft.aufirst=A&rft.date=1987-09-07&rft.volume=128&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+theoretical+biology&rft.issn=00225193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Glycine immunoreactivity localized in the cochlear nucleus and superior olivary complex. AN - 85264550; pmid-3683855 AB - Polyclonal antibodies were made in rabbits against glycine conjugated to bovine serum albumin with glutaraldehyde and were used for immunocytochemical studies in the cochlear nucleus and superior olivary nucleus of the guinea-pig. Antibodies selective for glycine were prepared by affinity chromatography. By dot-blot analysis this preparation showed a strong recognition of glycine conjugates and relatively little recognition of conjugates of most other amino acids tested. However, there was a significant reaction with conjugates of alanine and beta-alanine, and this cross-reaction could not be removed by affinity chromatography without eliminating the preparation's recognition of glycine. The affinity-purified preparation showed only a weak recognition of conjugates of gamma-aminobutyrate (GABA) which was detectable at high concentrations of primary antibody. Immunocytochemical studies showed several intensely staining cell bodies in the cochlear nucleus and superior olivary complex. Most immunoreactive cell bodies in the cochlear nucleus were in the dorsal cochlear nucleus, being present in both the superficial and deep layers. Scattered immunoreactive cells were present in the ventral cochlear nucleus. Intense staining of cell bodies was seen in the medial nucleus of the trapezoid body, and these cells appear to correspond to the principal cells of that nucleus. Punctate labelling, suggestive of immunoreactive presynaptic terminals, was also apparent, particularly in the ventral cochlear nucleus and lateral superior olive. In the ventral cochlear nucleus, immunoreactive puncta were found around unlabeled cell bodies, at times nearly covering the perimeter of the cell. A population of glycine-immunoreactive cell bodies in the superficial dorsal cochlear nucleus also labeled with anti-GABA antibodies as determined through double-labeling studies. However, glycine-positive cells in the deep dorsal cochlear nucleus were not labeled with anti-GABA antibodies, and some populations of GABA-positive cells in the superficial layers were not labeled with anti-glycine antibodies. In the hippocampus intense staining of cell bodies and puncta was seen with anti-GABA antibodies while essentially no staining was seen with anti-glycine antibodies. These results suggest that anti-glycine antibodies can be useful for immunocytochemical identification of glycinergic neurons. From this study several populations of putative glycinergic neurons are identified in the auditory nuclei of the brain stem using these antibodies. Some populations of GABA-containing neurons also contain high levels of glycine or a related molecule. JF - Neuroscience AU - Wenthold, Robert J AU - Huie, D AU - Altschuler, R A AU - Reeks, K A AD - National Institute on Deafness and Other Communication Disorders PY - 1987 SP - 897 EP - 912 VL - 22 IS - 3 SN - 0306-4522, 0306-4522 KW - Antibody Specificity KW - gamma-Aminobutyric Acid KW - Glycine KW - Guinea Pigs KW - Medulla Oblongata KW - Neurons KW - Animal KW - Cochlear Nerve KW - Rabbits KW - Immunohistochemistry KW - Female KW - Olivary Nucleus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85264550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Glycine+immunoreactivity+localized+in+the+cochlear+nucleus+and+superior+olivary+complex.&rft.au=Wenthold%2C+Robert+J%3BHuie%2C+D%3BAltschuler%2C+R+A%3BReeks%2C+K+A&rft.aulast=Wenthold&rft.aufirst=Robert&rft.date=1987-09-01&rft.volume=22&rft.issue=3&rft.spage=897&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - RO 15-4513 induces seizures in DBA/2 mice undergoing alcohol withdrawal. AN - 81100766; 3675863 AB - RO 15-4513, an imidazodiazepine that has been reported to reverse some of the behavioral effects of ethanol, was given to DBA/2 mice. Although no animals treated with a 6 mg/kg dose of this drug had seizures, 20% of animals given 20 mg/kg of this drug had tonic seizures. Ethanol withdrawal was induced in DBA/2 mice treated with 4-methyl pyrazole using an inhalation paradigm. Mice were more likely to have a seizure during ethanol withdrawal if treated with RO 15-4513 (6 mg/kg) than if they received the vehicle. These data suggest administering RO 15-4513 as an alcohol antagonist to alcoholic subjects may increase the incidence of seizures. JF - Alcohol (Fayetteville, N.Y.) AU - Lister, R G AU - Karanian, J W AD - Laboratory of Clinical Studies, NIAAA, Bethesda, MD 20892. PY - 1987 SP - 409 EP - 411 VL - 4 IS - 5 SN - 0741-8329, 0741-8329 KW - Azides KW - 0 KW - Benzodiazepines KW - 12794-10-4 KW - Ethanol KW - 3K9958V90M KW - Ro 15-4513 KW - 91917-65-6 KW - Index Medicus KW - Animals KW - Mice KW - Male KW - Mice, Inbred DBA KW - Seizures -- chemically induced KW - Ethanol -- adverse effects KW - Substance Withdrawal Syndrome -- metabolism KW - Azides -- pharmacology KW - Benzodiazepines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81100766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=RO+15-4513+induces+seizures+in+DBA%2F2+mice+undergoing+alcohol+withdrawal.&rft.au=Lister%2C+R+G%3BKaranian%2C+J+W&rft.aulast=Lister&rft.aufirst=R&rft.date=1987-09-01&rft.volume=4&rft.issue=5&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-24 N1 - Date created - 1987-12-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Structural significance of the GTP-binding domain of ras p21 studied by site-directed mutagenesis. AN - 81087610; 3118192 AB - Point mutations of p21 proteins were constructed by oligonucleotide-directed mutagenesis of the v-rasH oncogene, which substituted amino acid residues within the nucleotide-binding consensus sequence, GXG GXGK. When the glycine residue at position 10, 13, or 15 was substituted with valine, the viral rasH product p21 lost its GTP-binding and autokinase activities. Other substitutions at position 33, 51, or 59 did not impair its binding activity. G418-resistant NIH 3T3 cell lines were derived by transfection with constructs obtained by inserting the mutant proviral DNA into the pSV2neo plasmid. Clones with a valine mutation at position 13 or 15 were incapable of transforming cells, while all other mutants with GTP-binding activity were competent. A mutant with a substitution of valine for glycine at position 10 which had lost its ability to bind GTP and its autokinase activity was fully capable of transforming NIH 3T3 cells. These cells grew in soft agar and rapidly formed tumors in nude mice. The p21 of cell lines derived from tumor explants still lacked the autokinase activity. These findings suggest that the glycine-rich consensus sequence is important in controlling p21 activities and that certain mutations may confer to p21 its active conformation without participation of ligand binding. JF - Molecular and cellular biology AU - Clanton, D J AU - Lu, Y Y AU - Blair, D G AU - Shih, T Y AD - Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland 21701. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 3092 EP - 3097 VL - 7 IS - 9 SN - 0270-7306, 0270-7306 KW - Proto-Oncogene Proteins KW - 0 KW - Guanosine Diphosphate KW - 146-91-8 KW - Guanosine Triphosphate KW - 86-01-1 KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Animals KW - Guanosine Diphosphate -- metabolism KW - Neoplasms, Experimental -- genetics KW - Mice, Nude KW - Mice KW - Cell Line, Transformed KW - Mutation KW - Cloning, Molecular KW - Binding Sites KW - GTP-Binding Proteins -- metabolism KW - Proto-Oncogene Proteins -- metabolism KW - Proto-Oncogene Proteins -- genetics KW - Guanosine Triphosphate -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81087610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Structural+significance+of+the+GTP-binding+domain+of+ras+p21+studied+by+site-directed+mutagenesis.&rft.au=Clanton%2C+D+J%3BLu%2C+Y+Y%3BBlair%2C+D+G%3BShih%2C+T+Y&rft.aulast=Clanton&rft.aufirst=D&rft.date=1987-09-01&rft.volume=7&rft.issue=9&rft.spage=3092&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-14 N1 - Date created - 1987-12-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 1980 Jul;35(1):76-92 [6251279] Mol Cell Biol. 1987 May;7(5):1999-2002 [2439901] J Biol Chem. 1982 Oct 10;257(19):11767-73 [6288698] Nature. 1983 Apr 28;302(5911):842-4 [6843652] Science. 1983 Aug 26;221(4613):858-60 [6308763] Proc Natl Acad Sci U S A. 1984 May;81(9):2674-8 [6609366] Cell. 1984 May;37(1):151-8 [6609772] Cancer Invest. 1984;2(2):109-23 [6375822] Nature. 1984 Aug 23-29;310(5979):644-9 [6147754] Nature. 1984 Sep 20-26;311(5983):273-5 [6148703] Proc Natl Acad Sci U S A. 1984 Sep;81(18):5704-8 [6148751] DNA. 1984 Dec;3(6):479-88 [6096101] Proc Natl Acad Sci U S A. 1985 Jan;82(2):376-80 [2982154] J Cyclic Nucleotide Protein Phosphor Res. 1983-1984;9(6):435-48 [6396323] Nature. 1985 May 16-22;315(6016):242-5 [3923359] FEBS Lett. 1985 Jul 1;186(1):1-7 [2989003] Nature. 1985 Jun 27-Jul 3;315(6022):726-30 [2989702] Proc Natl Acad Sci U S A. 1985 Jul;82(13):4311-5 [2409555] Science. 1985 Oct 4;230(4721):32-6 [3898365] Science. 1985 Oct 4;230(4721):78-82 [3898366] Cell. 1986 Jan 17;44(1):167-76 [3510078] Proc Natl Acad Sci U S A. 1986 Feb;83(4):907-11 [2869483] Proc Natl Acad Sci U S A. 1986 Feb;83(4):952-6 [3513168] Nature. 1986 Jun 26-Jul 2;321(6073):814-6 [3088455] Proc Natl Acad Sci U S A. 1986 Jul;83(13):4607-11 [3088563] Proc Natl Acad Sci U S A. 1986 Jul;83(14):5076-80 [3014531] Science. 1986 Aug 8;233(4764):649-52 [3487832] Mol Cell Biol. 1985 Aug;5(8):1809-13 [3018526] J Biol Chem. 1986 Nov 5;261(31):14582-6 [3533923] Mol Cell Biol. 1986 Jul;6(7):2646-54 [3023943] Mol Cell Biol. 1986 Dec;6(12):4214-20 [3540608] Mol Cell Biol. 1987 Jan;7(1):541-4 [3550423] Nature. 1980 Oct 23;287(5784):686-91 [6253810] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cancer ecogenetics: studying genetic and environment interactions through epidemiology. AN - 81065859; 3667028 JF - International journal of epidemiology AU - Mulvihill, J J AU - Tulinius, H AD - Clinical Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 337 EP - 340 VL - 16 IS - 3 SN - 0300-5771, 0300-5771 KW - Index Medicus KW - Precancerous Conditions -- genetics KW - Oncogenes KW - Cocarcinogenesis KW - Epidemiologic Methods KW - Humans KW - Environmental Exposure KW - Models, Biological KW - Neoplasms -- genetics KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81065859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Cancer+ecogenetics%3A+studying+genetic+and+environment+interactions+through+epidemiology.&rft.au=Mulvihill%2C+J+J%3BTulinius%2C+H&rft.aulast=Mulvihill&rft.aufirst=J&rft.date=1987-09-01&rft.volume=16&rft.issue=3&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-08 N1 - Date created - 1987-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A simple approximation for calculating sample sizes for detecting linear trend in proportions. AN - 81056984; 3663825 AB - A simple approximate formula for sample sizes for detecting a linear trend in proportions is derived. The formulas for both the uncorrected and corrected Cochran-Armitage test are given. For two binomial proportions these reduce to those given by Casagrande, Pike, and Smith (1978, Biometrics 34, 483-486). Some numerical results of a power study for small sample sizes show that the nominal power corresponding to the approximate sample size is a reasonably good approximation to the actual power. JF - Biometrics AU - Nam, J M AD - Mathematical Statistics and Applied Mathematics Section, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 701 EP - 705 VL - 43 IS - 3 SN - 0006-341X, 0006-341X KW - Carcinogens KW - 0 KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Neoplasms, Experimental -- pathology KW - Research Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81056984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=A+simple+approximation+for+calculating+sample+sizes+for+detecting+linear+trend+in+proportions.&rft.au=Nam%2C+J+M&rft.aulast=Nam&rft.aufirst=J&rft.date=1987-09-01&rft.volume=43&rft.issue=3&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-02 N1 - Date created - 1987-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interactions of Ro 15-4513 with diazepam, sodium pentobarbital and ethanol in a holeboard test. AN - 81044476; 3659108 AB - Ro 15-4513 (1.5 mg/kg) decreased the exploratory activity of mice in a holeboard test. This effect was reversed by diazepam (1 mg/kg), ethanol (1 g/kg) and sodium pentobarbital (15 mg/kg). Higher doses of these three agents reduced the number of exploratory head-dips, and Ro 15-4513 antagonised these effects. These observations are consistent with the suggestion that Ro 15-4513 is a partial inverse agonist at benzodiazepine receptors and acts by reducing the efficacy of GABA. Ro 15-4513's interaction with ethanol in the holeboard closely resembled its interaction with the barbiturate. JF - Pharmacology, biochemistry, and behavior AU - Lister, R G AD - Laboratory of Clinical Studies, NIAAA, Bethesda, MD 20892. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 75 EP - 79 VL - 28 IS - 1 SN - 0091-3057, 0091-3057 KW - Azides KW - 0 KW - Benzodiazepines KW - 12794-10-4 KW - Ethanol KW - 3K9958V90M KW - Ro 15-4513 KW - 91917-65-6 KW - Pentobarbital KW - I4744080IR KW - Diazepam KW - Q3JTX2Q7TU KW - Index Medicus KW - Animals KW - Drug Interactions KW - Head KW - Motor Activity -- drug effects KW - Mice KW - Posture KW - Male KW - Ethanol -- pharmacology KW - Exploratory Behavior -- drug effects KW - Diazepam -- pharmacology KW - Azides -- pharmacology KW - Benzodiazepines -- pharmacology KW - Pentobarbital -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81044476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Interactions+of+Ro+15-4513+with+diazepam%2C+sodium+pentobarbital+and+ethanol+in+a+holeboard+test.&rft.au=Lister%2C+R+G&rft.aulast=Lister&rft.aufirst=R&rft.date=1987-09-01&rft.volume=28&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-05 N1 - Date created - 1987-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. AN - 81040196; 2443644 AB - This study examines the effects of repeated systemic administration (20 mg/kg s.c., twice daily for 4 days) of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on levels of brain monoamines, their metabolites and on the density of monoamine uptake sites in various regions of rat brain. Marked reductions (30-60%) in the concentration of 5-hydroxyindoleacetic acid were observed in cerebral cortex, hippocampus, striatum, hypothalamus and midbrain at 2 weeks after a 4-day treatment regimen of MDMA or MDA; less consistent reductions in serotonin (5-HT) content were observed in these brain regions. In addition, both MDMA and MDA caused comparable and substantial reductions (50-75%) in the density of [3H]paroxetine-labeled 5-HT uptake sites in all brain regions examined. In contrast, neither MDMA nor MDA caused any widespread or long-term changes in the content of the catecholaminergic markers (i.e., norepinephrine, dopamine, 3,4 dihydroxyphenylacetic acid and homovanillic acid) or in the number of [3H]mazindol-labeled norepinephrine or dopamine uptake sites in the brain regions examined. These data demonstrate that MDMA and MDA cause long-lasting neurotoxic effects with respect to both the functional and structural integrity of serotonergic neurons in brain. Furthermore, our measurement of reductions in the density of 5-HT uptake sites provides a means for quantification of the neurodegenerative effects of MDMA and MDA on presynaptic 5-HT terminals. JF - The Journal of pharmacology and experimental therapeutics AU - Battaglia, G AU - Yeh, S Y AU - O'Hearn, E AU - Molliver, M E AU - Kuhar, M J AU - De Souza, E B AD - Neuroscience Branch, National Institute on Drug Abuse, Baltimore, Maryland. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 911 EP - 916 VL - 242 IS - 3 SN - 0022-3565, 0022-3565 KW - Amphetamines KW - 0 KW - Piperidines KW - Receptors, Serotonin KW - Serotonin Antagonists KW - Tritium KW - 10028-17-8 KW - Serotonin KW - 333DO1RDJY KW - Paroxetine KW - 41VRH5220H KW - 3,4-Methylenedioxyamphetamine KW - 4764-17-4 KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Serotonin -- analysis KW - Hydroxyindoleacetic Acid -- analysis KW - Brain Chemistry -- drug effects KW - Dopamine -- metabolism KW - Serotonin -- metabolism KW - Male KW - Receptors, Serotonin -- drug effects KW - Brain -- drug effects KW - 3,4-Methylenedioxyamphetamine -- analogs & derivatives KW - Serotonin Antagonists -- metabolism KW - Piperidines -- metabolism KW - 3,4-Methylenedioxyamphetamine -- toxicity KW - Amphetamines -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81040196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=3%2C4-Methylenedioxymethamphetamine+and+3%2C4-methylenedioxyamphetamine+destroy+serotonin+terminals+in+rat+brain%3A+quantification+of+neurodegeneration+by+measurement+of+%5B3H%5Dparoxetine-labeled+serotonin+uptake+sites.&rft.au=Battaglia%2C+G%3BYeh%2C+S+Y%3BO%27Hearn%2C+E%3BMolliver%2C+M+E%3BKuhar%2C+M+J%3BDe+Souza%2C+E+B&rft.aulast=Battaglia&rft.aufirst=G&rft.date=1987-09-01&rft.volume=242&rft.issue=3&rft.spage=911&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-05 N1 - Date created - 1987-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Synergistic signals in the mechanism of antigen-induced exocytosis in 2H3 cells: evidence for an unidentified signal required for histamine release. AN - 81021841; 2443506 AB - The aim of this study was to determine whether the increase in cytosolic free Ca2+ concentration ([Ca2+]i) in response to antigen (aggregated ovalbumin) on IgE-primed 2H3 cells was sufficient to account for exocytosis. When the [Ca2+]i responses to antigen and the Ca2+ ionophore A23187 were compared, A23187 was much less effective at releasing histamine at equivalent [Ca2+]i increases, and little or no stimulated histamine release occurred with A23187 concentrations that matched the [Ca2+]i response to antigen concentrations that stimulated maximal histamine release. The [Ca2+]i response to antigen is not, therefore, sufficient to account for exocytosis, although extracellular Ca2+ is necessary to initiate both the [Ca2+]i response and histamine release: the antigen must generate an additional, unidentified, signal that is required for exocytosis. To determine whether this signal was the activation of protein kinase C, the effects of the phorbol ester 12-0-tetradecanoyl phorbol 13-acetate (TPA) on the responses to antigen were examined. TPA blocked the antigen-induced [Ca2+]i response and the release of inositol phosphates but had little effect on histamine release and did not stimulate exocytosis by itself. The unidentified signal from the antigen is therefore distinct from the activation of protein kinase C and is generated independently of the [Ca2+]i response or the release of inositol phosphates. Taken together with other data that imply that there is very little activation of protein kinase C by antigen when the rate of histamine release is maximal, it is concluded that the normal exocytotic response to antigen requires the synergistic action of the [Ca2+]i signal together with an unidentified signal that is not mediated by protein kinase C. JF - The Journal of cell biology AU - Beaven, M A AU - Guthrie, D F AU - Moore, J P AU - Smith, G A AU - Hesketh, T R AU - Metcalfe, J C AD - Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 1129 EP - 1136 VL - 105 IS - 3 SN - 0021-9525, 0021-9525 KW - Antigens KW - 0 KW - Calcimycin KW - 37H9VM9WZL KW - Ovalbumin KW - 9006-59-1 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Cells, Cultured KW - Kinetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Calcimycin -- pharmacology KW - Calcium -- metabolism KW - Exocytosis KW - Histamine Release -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81021841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+cell+biology&rft.atitle=Synergistic+signals+in+the+mechanism+of+antigen-induced+exocytosis+in+2H3+cells%3A+evidence+for+an+unidentified+signal+required+for+histamine+release.&rft.au=Beaven%2C+M+A%3BGuthrie%2C+D+F%3BMoore%2C+J+P%3BSmith%2C+G+A%3BHesketh%2C+T+R%3BMetcalfe%2C+J+C&rft.aulast=Beaven&rft.aufirst=M&rft.date=1987-09-01&rft.volume=105&rft.issue=3&rft.spage=1129&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+cell+biology&rft.issn=00219525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-02 N1 - Date created - 1987-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Physiol. 1968 Nov;199(1):177-87 [5684032] Nature. 1984 Aug 23-29;310(5979):691-3 [6236373] Nature. 1974 May 10;249(453):172-3 [4833520] Biochem J. 1974 Dec;144(3):543-50 [4468821] J Physiol. 1977 Sep;271(1):193-214 [72146] Nature. 1978 Nov 30;276(5687):513-5 [364317] Biochem J. 1981 Feb 15;194(2):497-505 [6796062] Kroc Found Ser. 1981;14:295-314 [6458668] J Biol Chem. 1983 Feb 10;258(3):2010-3 [6218169] Cell Calcium. 1982 Oct;3(4-5):323-35 [6218878] J Biol Chem. 1983 Apr 25;258(8):4876-82 [6601105] Endocrinology. 1983 Jul;113(1):424-6 [6861713] Biochem Biophys Res Commun. 1983 Jul 29;114(2):638-45 [6411090] FEBS Lett. 1983 Aug 22;160(1-2):98-100 [6884518] FEBS Lett. 1983 Sep 5;161(1):21-7 [6884525] Science. 1983 Sep 30;221(4618):1413-5 [6310757] FEBS Lett. 1985 Nov 11;192(1):13-8 [3840439] Nature. 1986 Jan 9-15;319(6049):150-3 [2417125] Nature. 1984 Nov 29-Dec 5;312(5993):453-5 [6504157] Nature. 1985 Jan 3-9;313(5997):59-60 [2578217] Immunol Lett. 1984;8(5):237-41 [6240439] J Biol Chem. 1985 Feb 25;260(4):2125-31 [2982810] FEBS Lett. 1985 Sep 23;189(2):345-9 [3930291] Nature. 1986 Feb 6-12;319(6053):504-7 [3003581] J Biol Chem. 1986 Feb 25;261(6):2583-92 [2419319] EMBO J. 1986 Jan;5(1):51-3 [3082623] J Biol Chem. 1986 Apr 15;261(11):4881-8 [3514606] FEBS Lett. 1986 May 26;201(1):137-42 [3086123] J Cell Biol. 1986 Jun;102(6):2197-204 [3011810] FEBS Lett. 1986 Dec 15;209(2):169-74 [3792543] Nature. 1983 Sep 22-28;305(5932):317-9 [6621685] Nature. 1983 Nov 3-9;306(5938):64-6 [6195532] J Biol Chem. 1984 Jun 10;259(11):7129-36 [6202691] J Biol Chem. 1984 Jun 10;259(11):7137-42 [6202692] Proc Natl Acad Sci U S A. 1984 Jul;81(13):3978-82 [6204334] Biochem J. 1984 Jun 1;220(2):345-60 [6146314] J Physiol. 1972 Aug;224(3):753-69 [4116105] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Separation and function of neutrophil karyogranuloplasts and comparison with cytoplasts and intact cells. AN - 81015909; 2820878 AB - Since neutrophil cytoplasts lacking nucleus and granules were first prepared by centrifuging neutrophils over a discontinuous Ficoll gradient containing cytochalasin B, several functional deficits have been reported in these cytoplasts. Although these functional deficits have been considered to originate from the absence of organelles, cell damage during preparation could not be excluded. Therefore, in the following experiments the Ficoll gradient was modified to isolate both cytoplasts and karyogranuloplasts, which have a nucleus and granules and represent the cell after loss of the cytoplast. Electron microscopy and analysis of marker proteins and cell volume showed that karyogranuloplasts were distinct from neutrophils. The phorbol myristate acetate (PMA) or N-formylmethionylleucylphenylalanine (FMLP)-induced O2- release, corrected by surface area, was in the following order: neutrophils greater than cytoplasts greater than karyogranuloplasts. Both aggregation and membrane potential depolarization were maximal in neutrophils, intermediate in karyogranuloplasts, and lowest in cytoplasts when either PMA or FMLP was used as a stimulant. Extracellular release of the granule contents (degranulation) was triggered by FMLP in both neutrophils and karyogranuloplasts. Cytochalasin B pretreatment greatly enhanced FMLP-induced O2- release, degranulation, aggregation, and depolarization of membrane potential in neutrophils and karyogranuloplasts, but not in cytoplasts. The ability of cytochalasin B to potentiate FMLP-triggered cell function probably depends on granules or cell organelles which are depleted in cytoplasts. Chemokinesis and chemotaxis were impaired in both karyogranuloplasts and cytoplasts. Specific FML[3H]P binding was greater in karyogranuloplasts than in cytoplasts. Cellular actin content, measured by the DNase I inhibition assay, was abundant in cytoplasts and was extremely low in karyogranuloplasts. Karyogranuloplasts retain various neutrophil functions, except for chemotaxis, and provide an important control when studying the role of cell organelles in cytoplast function. JF - Inflammation AU - Ohno, Y AU - Falloon, J AU - Seligmann, B E AU - Nath, J AU - Friedman, M M AU - Gallin, J I AD - Bacterial Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 289 EP - 307 VL - 11 IS - 3 SN - 0360-3997, 0360-3997 KW - Superoxides KW - 11062-77-4 KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - N-formylmethionyl-leucyl-phenylalanyl-lysine KW - 81213-55-0 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Osmolar Concentration KW - Cytoplasmic Granules -- ultrastructure KW - Cell Aggregation -- drug effects KW - Cell Nucleus -- ultrastructure KW - Humans KW - Cytoplasmic Granules -- metabolism KW - N-Formylmethionine Leucyl-Phenylalanine -- analogs & derivatives KW - N-Formylmethionine Leucyl-Phenylalanine -- pharmacology KW - Superoxides -- metabolism KW - Organoids -- ultrastructure KW - Cell Movement -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Microscopy, Electron KW - Neutrophils -- drug effects KW - Neutrophils -- classification KW - Neutrophils -- ultrastructure KW - Neutrophils -- physiology KW - Cell Separation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81015909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inflammation&rft.atitle=Separation+and+function+of+neutrophil+karyogranuloplasts+and+comparison+with+cytoplasts+and+intact+cells.&rft.au=Ohno%2C+Y%3BFalloon%2C+J%3BSeligmann%2C+B+E%3BNath%2C+J%3BFriedman%2C+M+M%3BGallin%2C+J+I&rft.aulast=Ohno&rft.aufirst=Y&rft.date=1987-09-01&rft.volume=11&rft.issue=3&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Inflammation&rft.issn=03603997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-10-28 N1 - Date created - 1987-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Species variation in bladder cell and liver cell activation of acetylaminofluorene. AN - 78050405; 3333732 AB - The metabolism and mutagenicity of 2-acetylaminofluorene were measured using freshly prepared intact bladder and liver cells from the cow, dog and rat. High pressure liquid chromatography was used to separate 2-acetylaminofluorene metabolites, and Salmonella typhimurium, strain TA98, was used to detect mutagenic intermediates. Species differences as well as animal-to-animal variation within a species were observed. Mutagenic activity with 2-acetylaminofluorene was greater with cow bladder cells than with dog or rat bladder cells. However, dog bladder cells were most active in metabolizing 2-acetylaminofluorene, and rat bladder cells were least active. Liver cells from all three species metabolized 2-acetylaminofluorene to mutagens for Salmonella, with dog and cow cells being more active than rat liver cells. However, cow liver cells were the most active in metabolizing 2-acetylaminofluorene, followed by rat and dog cells. With all cell types studied, except rat bladder cells, aminofluorene was the major metabolite detected. Carbon and N-hydroxylated products were produced by liver and bladder cells of the three species and glucuronide and sulfate conjugates of the metabolites were detected from both cell types. Correlations between mutagenic activity and the level of metabolism or any individual metabolite were not apparent. The data suggest that the relative contribution of bladder cell metabolism in aromatic amine induced bladder cancer may vary with the species. JF - Cell biology and toxicology AU - Langenbach, R AU - Rudo, K AU - Ellis, S AU - Hix, C AU - Nesnow, S AD - Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 303 EP - 319 VL - 3 IS - 3 SN - 0742-2091, 0742-2091 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Rats KW - Animals KW - Mutagenicity Tests KW - Cattle KW - Biotransformation KW - Dogs KW - Species Specificity KW - Salmonella typhimurium -- genetics KW - Urinary Bladder -- metabolism KW - 2-Acetylaminofluorene -- toxicity KW - 2-Acetylaminofluorene -- metabolism KW - Liver -- metabolism KW - 2-Acetylaminofluorene -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78050405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+biology+and+toxicology&rft.atitle=Species+variation+in+bladder+cell+and+liver+cell+activation+of+acetylaminofluorene.&rft.au=Langenbach%2C+R%3BRudo%2C+K%3BEllis%2C+S%3BHix%2C+C%3BNesnow%2C+S&rft.aulast=Langenbach&rft.aufirst=R&rft.date=1987-09-01&rft.volume=3&rft.issue=3&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Cell+biology+and+toxicology&rft.issn=07422091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-01 N1 - Date created - 1989-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - IgE-immunotoxins. I. IgE-intact ricin. AN - 77850036; 2445711 AB - An IgE immunotoxin consisting of rat IgE myeloma protein, IR 162, conjugated via the heterobifunctional linking agent N-succinimidyl-3-(2-pyridyldithio)propionate to intact ricin was synthesized and evaluated. The capacity of this IgE-immunotoxin to bind to rat basophilic leukemia cells (RBL cells) and to inhibit RBL cell incorporation of [3H]leucine was assessed. The IgE-intact ricin conjugate sensitized RBL cells for histamine release after treatment with anti-IgE with a time-course of sensitization and dose-response equivalent to native IgE. Intact ricin and IgE-intact ricin were both cytotoxic to RBL cells as assessed by [3H]leucine incorporation. Lactose (50 mM) competed with intact ricin binding and toxicity such that more than 100 ng/ml ricin (8 times its IC50 in the absence of lactose) was required for ricin to kill RBL cells in the presence of lactose. Lactose (50 mM) was not able to fully inhibit 1-100 ng/ml IgE-ricin immunotoxin killing of RBL cells. Saturation of RBL cell IgE receptors by preincubation with IgE totally inhibited IgE-intact ricin-induced toxicity, in the presence of lactose, indicating that toxicity required IgE Fc receptor binding. JF - Immunopharmacology AU - Boltansky, H AU - Dyer, J AU - Esworthy, S AU - Kaliner, M AD - Allergy Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 35 EP - 45 VL - 14 IS - 1 SN - 0162-3109, 0162-3109 KW - Immunotoxins KW - 0 KW - Receptors, Fc KW - Immunoglobulin E KW - 37341-29-0 KW - Ricin KW - 9009-86-3 KW - Cycloheximide KW - 98600C0908 KW - Lactose KW - J2B2A4N98G KW - Index Medicus KW - Rats KW - Lactose -- pharmacology KW - Animals KW - Dose-Response Relationship, Drug KW - Cycloheximide -- pharmacology KW - Histamine Release KW - Receptors, Fc -- metabolism KW - Immunoglobulin E -- immunology KW - Immunotoxins -- pharmacology KW - Ricin -- pharmacology KW - Immunoglobulin E -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77850036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunopharmacology&rft.atitle=IgE-immunotoxins.+I.+IgE-intact+ricin.&rft.au=Boltansky%2C+H%3BDyer%2C+J%3BEsworthy%2C+S%3BKaliner%2C+M&rft.aulast=Boltansky&rft.aufirst=H&rft.date=1987-09-01&rft.volume=14&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Immunopharmacology&rft.issn=01623109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-15 N1 - Date created - 1988-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - IgE-immunotoxins. II. IgE-ricin A-chain. AN - 77838949; 3500150 AB - In order to develop a reagent capable of killing cells with high-affinity IgE Fc receptors, such as mast cells and basophils, ricin A-chain (the toxic portion of ricin) was conjugated to rat IgE myeloma protein, IR 162, via derivatization of the IgE by n-succinimidyl-3-(2-pyridyldithio)propionate (SPDP) thus creating an IgE-immunotoxin. Monensin (10(-7)-10(-8)M), a carboxylic ionophore, facilitated IgE-ricin A-chain (3 X 10(-7)M) toxicity in a dose-related fashion ith significant reductions in [3H]leucine incorporation compared to cells exposed only to monensin. This enhanced toxicity could be inhibited by the addition of both anti-ricin A-chain or anti-IgE, suggesting that different routes of intracellular processing may play a role in determining the toxicity of the IgE-ricin A-chain conjugate. Ricin B-chain (5 X 10(-7) and 5 X 10(-8)M) added to free ricin A-chain (10(-6)-10(-8)M) reproducibly facilitated toxicity, and this toxicity could be inhibited (30-90%) by lactose (50 mM). Ricin B-chain also facilitated IgE-ricin A-chain (2.75 X 10(-8)M) toxicity; however, this toxicity was not affected by lactose. The data suggest that ricin B-chain potentiates the cytosolic access of internalized IgE-immunotoxin and that the binding and internalization of the toxin was mediated via the IgE Fc receptor. A second type of IgE-ricin A-chain conjugate was synthesized whereby both IgE and ricin A-chain were derivatized with SPDP. RBL cells were killed in a dose-dependent manner by this IgE-ricin A-chain conjugate (2.5 X 10(-6)-2.5 X 10(-9)M) without requiring the addition of monensin or ricin B-chain. These data indicate that the intracellular route and processing of internalized immunotoxin is critical to eliciting toxicity. JF - Immunopharmacology AU - Boltansky, H AU - Slater, J AU - Youle, R AU - Isersky, C AU - Kaliner, M AD - Allergy Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 47 EP - 62 VL - 14 IS - 1 SN - 0162-3109, 0162-3109 KW - Immunotoxins KW - 0 KW - Receptors, Fc KW - Immunoglobulin E KW - 37341-29-0 KW - Ricin KW - 9009-86-3 KW - Monensin KW - 906O0YJ6ZP KW - Lactose KW - J2B2A4N98G KW - Index Medicus KW - Lactose -- pharmacology KW - Protein Biosynthesis -- drug effects KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - Dose-Response Relationship, Drug KW - Rabbits KW - Monensin -- pharmacology KW - Receptors, Fc -- metabolism KW - Immunotoxins -- analysis KW - Immunoglobulin E -- immunology KW - Immunotoxins -- pharmacology KW - Ricin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77838949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunopharmacology&rft.atitle=IgE-immunotoxins.+II.+IgE-ricin+A-chain.&rft.au=Boltansky%2C+H%3BSlater%2C+J%3BYoule%2C+R%3BIsersky%2C+C%3BKaliner%2C+M&rft.aulast=Boltansky&rft.aufirst=H&rft.date=1987-09-01&rft.volume=14&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Immunopharmacology&rft.issn=01623109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-15 N1 - Date created - 1988-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Chronic carcinogenesis studies of acrolein and related compounds. AN - 77832000; 3686537 AB - Acrolein and two of its more stable derivatives, the oxime and the diethylacetal, and the related allyl alcohol were given in drinking water to groups of 20 male and 20 female F344 rats at doses close to the maximum that could be tolerated by the animals, for most of their lifetime. Acetaldoxime served as a control for the hydroxylamine derivative of acrolein. Most of the tumors were common in untreated rats of this strain. Only adenomas of the adrenal cortex in females were more numerous than in untreated controls. Acrolein itself was too toxic to hamsters to conduct a carcinogenesis study. Acrolein oxime, acrolein diethylacetal and allyl alcohol were all quite toxic to hamsters, but 2 mg per week by gavage was tolerated by groups of 20 male Syrian hamsters. There was a small number of tumors of the pancreatic ducts and of the forestomach in the treated hamsters, but the incidence was not statistically significant. JF - Toxicology and industrial health AU - Lijinsky, W AU - Reuber, M D AD - LBI-Basic Research Program, NCI-Frederick Cancer Research Facility, MD 21701. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 337 EP - 345 VL - 3 IS - 3 SN - 0748-2337, 0748-2337 KW - Aldehydes KW - 0 KW - Carcinogens KW - Propanols KW - acrolein diethylacetal KW - 33XN703369 KW - allyl alcohol KW - 3W678R12M0 KW - acrolein oxime KW - 5314-33-0 KW - Acrolein KW - 7864XYD3JJ KW - 1-Propanol KW - 96F264O9SV KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Sex Factors KW - Adenoma -- chemically induced KW - 1-Propanol -- toxicity KW - Mesocricetus KW - Adrenal Cortex Neoplasms -- chemically induced KW - Male KW - Female KW - Cricetinae KW - Aldehydes -- toxicity KW - Acrolein -- analogs & derivatives KW - Acrolein -- toxicity KW - Acrolein -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77832000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Chronic+carcinogenesis+studies+of+acrolein+and+related+compounds.&rft.au=Lijinsky%2C+W%3BReuber%2C+M+D&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1987-09-01&rft.volume=3&rft.issue=3&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-18 N1 - Date created - 1987-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pathologic Effects of Chronic Administration of Hydrochlorothiazide, with and without Sodium Nitrite, to F344 Rats AN - 760214801; 13641417 AB - The diuretic drug hydrochlorothiazide was administered to 24 male and 24 female F344 rats as a mixture of 0.1% in powdered food. A parallel group of the same size was given 0.1% hydrochlorothiazide plus 0.2% sodium nitrite in the food. A third group received 0.2% sodium nitrite in the food and there was a similar group of untreated controls. The treatments were well tolerated and there was no significant life shortening. A majority of the rats given hydrochlorothiazide, with or without nitrite, developed chronic progressive nephropathy, which was more severe in males than in females. Associated with this were diffuse parathyroid hyperplasia in both groups receiving the drug, also more severe in males than in females, and parallel increases in lesions of the blood vessels (mural thrombosis of the heart and polyarteritis). The few adenomas of the parathyroid and tubular cell adenomas of the kidney in rats ingesting hydrochlorothiazide were not statistically significant. JF - Toxicology and Industrial Health AU - Lijinsky, William AU - Reuber, Melvin D AD - LBI-Basic Research Program Chemical Carcinogenesis Laboratory NCI-Frederick Cancer Research Facility Frederick, Maryland Y1 - 1987/09// PY - 1987 DA - Sep 1987 SP - 413 EP - 422 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 3 IS - 3 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts KW - Heart KW - Food KW - Diuretics KW - Statistical analysis KW - Sodium nitrite KW - Sex differences KW - Hydrochlorothiazide KW - Thrombosis KW - Hyperplasia KW - Parathyroid KW - Blood vessels KW - Nephropathy KW - Kidney KW - Nitrite KW - Drugs KW - Adenoma KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760214801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Pathologic+Effects+of+Chronic+Administration+of+Hydrochlorothiazide%2C+with+and+without+Sodium+Nitrite%2C+to+F344+Rats&rft.au=Lijinsky%2C+William%3BReuber%2C+Melvin+D&rft.aulast=Lijinsky&rft.aufirst=William&rft.date=1987-09-01&rft.volume=3&rft.issue=3&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F074823378700300313 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 7 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Heart; Food; Diuretics; Statistical analysis; Sodium nitrite; Sex differences; Hydrochlorothiazide; Thrombosis; Parathyroid; Hyperplasia; Blood vessels; Nephropathy; Kidney; Nitrite; Adenoma; Drugs DO - http://dx.doi.org/10.1177/074823378700300313 ER - TY - JOUR T1 - Recombinant DNA research; proposed actions under guidelines; notice. AN - 77357190; 11655869 JF - Federal register AU - U.S. National Institutes of Health AD - U.S. National Institutes of Health Y1 - 1987/08/11/ PY - 1987 DA - 1987 Aug 11 SP - 29800 EP - 29814 VL - 52 IS - 154 SN - 0097-6326, 0097-6326 KW - DNA, Recombinant KW - 0 KW - Hazardous Substances KW - Bioethics KW - Biomedical and Behavioral Research KW - Department of Agriculture KW - National Institutes of Health KW - NIH Guidelines KW - Legal Approach KW - United States KW - Ecology KW - Animals KW - Government KW - Animal Welfare KW - Animal Experimentation KW - Federal Government KW - Government Regulation KW - Social Control, Formal KW - National Institutes of Health (U.S.) KW - Containment of Biohazards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77357190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Recombinant+DNA+research%3B+proposed+actions+under+guidelines%3B+notice.&rft.au=U.S.+National+Institutes+of+Health&rft.aulast=U.S.+National+Institutes+of+Health&rft.aufirst=&rft.date=1987-08-11&rft.volume=52&rft.issue=154&rft.spage=29800&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-23 N1 - Date created - 1988-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human P-450 genes: evolution, regulation and possible role in carcinogenesis. AN - 81120528; 3678581 JF - Biochemical Society transactions AU - Nebert, D W AU - Jaiswal, A K AU - Meyer, U A AU - Gonzalez, F J AD - Laboratory of Development Pharmacology, National Institute of Child Health and Human Development, Bethesda, MD 20892. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 586 EP - 589 VL - 15 IS - 4 SN - 0300-5127, 0300-5127 KW - DNA KW - 9007-49-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Debrisoquin KW - X31CDK040E KW - Index Medicus KW - Debrisoquin -- metabolism KW - Polymorphism, Genetic KW - Biological Evolution KW - Multigene Family KW - Humans KW - DNA -- genetics KW - Gene Expression Regulation KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Neoplasms -- genetics KW - Cloning, Molecular KW - Cytochrome P-450 Enzyme System -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81120528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Society+transactions&rft.atitle=Human+P-450+genes%3A+evolution%2C+regulation+and+possible+role+in+carcinogenesis.&rft.au=Nebert%2C+D+W%3BJaiswal%2C+A+K%3BMeyer%2C+U+A%3BGonzalez%2C+F+J&rft.aulast=Nebert&rft.aufirst=D&rft.date=1987-08-01&rft.volume=15&rft.issue=4&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=Biochemical+Society+transactions&rft.issn=03005127&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-11 N1 - Date created - 1988-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Hypothesis: a role for quinolinic acid in the neuropathology of glutaric aciduria type I. AN - 81109776; 2960429 AB - Glutaric aciduria type I is an autosomal recessive metabolic disorder of children associated with severe dystonic motor disturbances and degeneration in the cerebral cortex, striatum and cerebellum. Biochemical studies demonstrate a deficiency in the enzyme glutaryl-CoA dehydrogenase. This enzyme metabolizes substrate derived from dietary tryptophan that could otherwise be converted to quinolinic acid within the brain. The law of mass action predicts that the production of quinolinic acid should be increased in glutaric aciduria type I. Quinolinic acid is a potent neurotoxin and convulsant when it is injected into the central nervous system of experimental animals. This paper argues that quinolinic acid may accumulate within the brain and cause the neuropathology of glutaric aciduria type I. JF - The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques AU - Heyes, M P AD - Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20837. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 441 EP - 443 VL - 14 IS - 3 Suppl SN - 0317-1671, 0317-1671 KW - Glutarates KW - 0 KW - Neurotoxins KW - Pyridines KW - Quinolinic Acids KW - Oxidoreductases KW - EC 1.- KW - Oxidoreductases Acting on CH-CH Group Donors KW - EC 1.3.- KW - Glutaryl-CoA Dehydrogenase KW - EC 1.3.8.6 KW - Quinolinic Acid KW - F6F0HK1URN KW - glutaric acid KW - H849F7N00B KW - Index Medicus KW - Neurotoxins -- metabolism KW - Humans KW - Child KW - Quinolinic Acids -- physiology KW - Quinolinic Acids -- metabolism KW - Oxidoreductases -- deficiency KW - Brain Diseases -- physiopathology KW - Pyridines -- metabolism KW - Glutarates -- urine KW - Brain Diseases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81109776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Canadian+journal+of+neurological+sciences.+Le+journal+canadien+des+sciences+neurologiques&rft.atitle=Hypothesis%3A+a+role+for+quinolinic+acid+in+the+neuropathology+of+glutaric+aciduria+type+I.&rft.au=Heyes%2C+M+P&rft.aulast=Heyes&rft.aufirst=M&rft.date=1987-08-01&rft.volume=14&rft.issue=3+Suppl&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=The+Canadian+journal+of+neurological+sciences.+Le+journal+canadien+des+sciences+neurologiques&rft.issn=03171671&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-13 N1 - Date created - 1988-01-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential susceptibility of immature rat testes to doxorubicin at critical stages of maturation. Biochemical and functional assessment. AN - 81062320; 3662816 AB - The toxic effects of doxorubicin on the reproductive system of the male rat were studied at different susceptible stages of postnatal development. A multidisciplinary approach including the assessment of histopathological, functional and biochemical parameters was chosen. Groups of male rats were treated once with the compound (3 mg/kg) on postnatal day 6, 16, 24 or 45. Both the onset of reproductive capacity and fertility were determined by serially mating ten animals per group for 12 weeks beginning at the age of 45 days. Reproductive organ weights, sperm counts and epididymal androgen binding protein (ABP) were measured at intermediate (80-day-old rats) or terminal sacrifice (129-day-old rats). Age dependent differential doxorubicin toxicity was evident. Treatment of 6-day-old animals with doxorubicin severely impaired development of reproductive functions. Treatment of 16-day-old animals reduced fertility throughout the mating study, as well as body and reproductive organ weights and sperm counts. Initial toxicity was observed in the group treated at 24 days of age; particularly, low reproductive organ weights and low sperm counts were found. These findings proved reversible towards the end of the study. Neither biochemical nor functional impairment of the reproductive system could be observed in the group treated at 45 days of age. JF - Archives of toxicology AU - Bechter, R AU - Haebler, R AU - Ettlin, R A AU - Haseman, J K AU - Dixon, R L AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 415 EP - 421 VL - 60 IS - 6 SN - 0340-5761, 0340-5761 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Sperm Count KW - Epididymis -- drug effects KW - Time Factors KW - Male KW - Organ Size -- drug effects KW - Fertility -- drug effects KW - Testis -- growth & development KW - Testis -- metabolism KW - Testis -- drug effects KW - Doxorubicin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81062320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Differential+susceptibility+of+immature+rat+testes+to+doxorubicin+at+critical+stages+of+maturation.+Biochemical+and+functional+assessment.&rft.au=Bechter%2C+R%3BHaebler%2C+R%3BEttlin%2C+R+A%3BHaseman%2C+J+K%3BDixon%2C+R+L&rft.aulast=Bechter&rft.aufirst=R&rft.date=1987-08-01&rft.volume=60&rft.issue=6&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=03405761&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-12 N1 - Date created - 1987-11-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nonneoplastic lesions of the ovary in Fischer 344 rats and B6C3F1 mice. AN - 81059513; 3665871 AB - The National Toxicology Program's pathology database on 2-year carcinogenicity studies was reviewed for nonneoplastic ovarian disease. Ovaries from 39,941 female Fischer rats and 41,444 female B6C3F1 mice were examined. A variety of inflammatory, degenerative, vascular, and proliferative lesions were documented and are described. The most common ovarian lesions in rats were cysts (6%). The most frequent ovarian lesions in mice were cysts (15%), acute inflammation (4%), degeneration (4%), vascular disease (2.5%), and atrophy (2%). There was no difference in incidence of ovarian disease between controls and treated animals. The frequency of ovarian disease in mice exceeded the frequency in rats in every category. JF - Environmental health perspectives AU - Montgomery, C A AU - Alison, R H AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 53 EP - 75 VL - 73 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Rats KW - Animals KW - Ovarian Cysts -- pathology KW - Mice KW - Pigmentation Disorders -- pathology KW - Species Specificity KW - Female KW - Rats, Inbred Strains KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Ovary -- pathology KW - Ovarian Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81059513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Nonneoplastic+lesions+of+the+ovary+in+Fischer+344+rats+and+B6C3F1+mice.&rft.au=Montgomery%2C+C+A%3BAlison%2C+R+H&rft.aulast=Montgomery&rft.aufirst=C&rft.date=1987-08-01&rft.volume=73&rft.issue=&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-14 N1 - Date created - 1987-12-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bull World Health Organ. 1976;53(2-3):203-15 [1086151] Methods Achiev Exp Pathol. 1975;7:132-48 [172762] Jikken Dobutsu. 1977 Jan;26(1):1-12 [558098] Am J Pathol. 1977 Jun;87(3):686-720 [194486] Biol Reprod. 1977 Sep;17(2):155-61 [889990] J Reprod Fertil. 1977 Sep;51(1):159-61 [915870] Exp Gerontol. 1978;13(3-4):159-66 [689112] J Natl Cancer Inst. 1979 Sep;63(3):849-54 [288939] Toxicol Appl Pharmacol. 1979 Apr;48(2):237-48 [473173] Exp Aging Res. 1979 Aug;5(4):319-33 [574826] Biol Reprod. 1980 Mar;22(2):343-50 [6769514] Toxicol Appl Pharmacol. 1980 Sep 30;55(3):433-47 [7434356] J Natl Cancer Inst. 1981 Sep;67(3):693-702 [6268882] Jikken Dobutsu. 1981 Oct;30(4):487-90 [7198583] Gan. 1982 Feb;73(1):153-7 [6811356] Lab Anim Sci. 1983 Jun;33(3):273-86 [6876733] J Natl Cancer Inst. 1984 Jun;72(6):1383-95 [6587157] Vet Pathol. 1984 May;21(3):292-9 [6730218] Pathology. 1984 Apr;16(2):131-5 [6431385] Nature. 1966 Jul 16;211(5046):319-20 [4381647] Eur J Cancer. 1968 Jan;3(6):537-43 [4295127] Am J Obstet Gynecol. 1969 Apr 15;103(8):1078-83 [5813184] Endocrinology. 1970 Apr;86(4):914-7 [5413539] J Natl Cancer Inst. 1972 May;48(5):1283-95 [4337905] Cancer Res. 1977 Jan;37(1):67-75 [830422] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ovarian neoplasms in F344 rats and B6C3F1 mice. AN - 81058385; 3665872 AB - The National Toxicology Program (NTP) classification system for rat and mouse ovarian tumors is presented. The classification system is based on previous classification systems and on a review of all the primary ovarian tumors from the archives of the National Cancer Institute (NCI) and NTP Carcinogenesis Testing Programs. The relative frequency and principal diagnostic features of 204 ovarian tumors from 39,851 female F344 rats and 587 ovarian tumors from 41,102 female B6C3F1 mice are described. The most frequently observed neoplasms in F344 rats were malignant granulosa cell tumors (29% of primary rat ovarian neoplasms observed), benign undifferentiated sex cord-stromal tumors (26%), benign granulosa cell tumors (16%), and benign Sertoli cell tumors (7%). The most frequent neoplasms in B6C3F1 mice were cystadenomas (24%), tubulostromal adenomas (24%), benign granulosa cell tumors (21%), and benign teratomas (8%). JF - Environmental health perspectives AU - Alison, R H AU - Morgan, K T AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 91 EP - 106 VL - 73 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Rats KW - Dysgerminoma -- pathology KW - Animals KW - Cystadenocarcinoma -- pathology KW - Teratoma -- pathology KW - Granulosa Cell Tumor -- pathology KW - Mice KW - Adenoma -- pathology KW - Female KW - Cystadenoma -- pathology KW - Adenocarcinoma -- pathology KW - Rats, Inbred Strains KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Ovarian Neoplasms -- pathology KW - Ovarian Neoplasms -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81058385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Ovarian+neoplasms+in+F344+rats+and+B6C3F1+mice.&rft.au=Alison%2C+R+H%3BMorgan%2C+K+T&rft.aulast=Alison&rft.aufirst=R&rft.date=1987-08-01&rft.volume=73&rft.issue=&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-14 N1 - Date created - 1987-12-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pathology. 1973 Oct;5(4):303-10 [4780533] Acta Unio Int Contra Cancrum. 1963;19:779-82 [14050667] Bull World Health Organ. 1976;53(2-3):203-15 [1086151] Am J Pathol. 1977 Jun;87(3):686-720 [194486] J Natl Cancer Inst. 1981 Sep;67(3):693-702 [6268882] J Reprod Med. 1983 Jan;28(1):17-23 [6187917] Tumori. 1983 Jun 30;69(3):195-9 [6868136] Int J Gynecol Pathol. 1982;1(1):101-23 [6307900] Br J Cancer. 1983 Aug;48(2):301-5 [6882668] J Natl Cancer Inst. 1984 Jan;72(1):151-60 [6582295] Clin Obstet Gynaecol. 1984 Apr;11(1):93-134 [6325076] J Natl Cancer Inst. 1984 Jun;72(6):1383-95 [6587157] Vet Pathol. 1984 May;21(3):292-9 [6730218] J Pathol. 1985 Feb;145(2):127-48 [2983057] Cancer Res. 1985 Nov;45(11 Pt 2):5575-81 [4053032] J Natl Cancer Inst. 1986 Feb;76(2):283-9 [3456066] Vet Pathol. 1986 Nov;23(6):776-8 [3811143] Environ Health Perspect. 1987 Aug;73:77-90 [2822382] Gan. 1975 Jun;66(3):323-5 [1181233] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ovarian toxicity and carcinogenicity in eight recent National Toxicology Program studies. AN - 81057113; 3665857 AB - Ovarian toxicity and/or carcinogenicity has been documented for at least eight chemicals recently tested in National Toxicity Program prechronic and chronic rodent studies. The chemicals that yielded treatment-related ovarian lesions were 1,3-butadiene, 4-vinylcyclohexene, vinylcyclohexene deipoxide, nitrofurantoin, nitrofurazone, benzene, delta-9-tetrahydrocannabinol, and tricresylphosphate. Typical nonneoplastic ovarian changes included hypoplasia, atrophy, follicular necrosis, and tubular hyperplasia. The most commonly observed treatment-related neoplasms were granulosa cell tumors and benign mixed tumors. A relationship between antecedent ovarian hypoplasia, atrophy, and hyperplasia and subsequent ovarian neoplasia is supported by some of these National Toxicology Program studies. Pathologic changes in other tissues such as the adrenal glands and uterus were associated with the treatment-related ovarian changes. JF - Environmental health perspectives AU - Maronpot, R R AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 125 EP - 130 VL - 73 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Index Medicus KW - United States KW - Rats KW - Animals KW - National Institutes of Health (U.S.) KW - Mice KW - Drug Evaluation, Preclinical KW - Female KW - Ovary -- pathology KW - Ovarian Neoplasms -- pathology KW - Ovary -- drug effects KW - Carcinogens -- toxicity KW - Ovarian Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81057113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Ovarian+toxicity+and+carcinogenicity+in+eight+recent+National+Toxicology+Program+studies.&rft.au=Maronpot%2C+R+R&rft.aulast=Maronpot&rft.aufirst=R&rft.date=1987-08-01&rft.volume=73&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-14 N1 - Date created - 1987-12-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1985 Nov;45(11 Pt 2):5575-81 [4053032] J Endocrinol. 1961 Feb;21:469-95 [13790510] Am J Epidemiol. 1974 Mar;99(3):190-209 [4814690] Gynecol Oncol. 1979 Jun;7(3):325-44 [447120] Am J Epidemiol. 1981 Sep;114(3):398-405 [7304575] Science. 1985 Feb 1;227(4686):548-9 [3966163] Am J Ind Med. 1983;4(1-2):163-73 [6188376] Am J Ind Med. 1983;4(1-2):175-90 [6340477] Am J Ind Med. 1983;4(1-2):191-202 [6301272] Am J Ind Med. 1983;4(1-2):365-79 [6340483] Am J Ind Med. 1983;4(1-2):65-79 [6340485] Am J Ind Med. 1983;4(1-2):107-12 [6301271] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alloimmune cells consume interleukin-2 and competitively inhibit the anti-tumour effects of interleukin-2. AN - 81054259; 2444243 AB - Adoptive immunotherapy with lymphokine activated killer (LAK) cells and recombinant interleukin-2 (IL-2) is successful in a variety of tumour models in both the normal and the immunocompromised mouse. We investigated the effects of an immune response to an allogeneic challenge on the metabolism of IL-2. Serum IL-2 levels at different time points after the administration of 20,000 units of IL-2 intraperitoneally were 2-4 fold higher in normal mice than in recently alloimmunized mice. In an intraperitoneal tumour model the alloimmunization of mice with allogeneic P815 tumour cells or splenocytes IP prior to the intraperitoneal inoculation of syngeneic tumour significantly diminished the anti-tumour effects of IL-2 and LAK cell immunotherapy in 7 consecutive experiments. High doses of IL-2 or pretreatment with cyclophosphamide restored the efficacy of IL-2 and LAK cell immunotherapy. From these results we hypothesize that T cells, activated by the allogeneic challenge, consume IL-2 and thus inhibit the effects of IL-2 and LAK cell treatment by competitive inhibition. LAK cell activity with reduced levels of IL-2 cannot be maintained and anti-tumour effects are lost. High doses of IL-2 were shown to overcome the competition for IL-2. Alternatively activated T-cells could be eliminated by pretreatment with cyclophosphamide and anti-tumour effects restored. These results are important in that they provide an alternative explanation as to the mechanism of non-specific cell mediated suppression and may in part explain the failure of some cancer patients to respond to treatment with IL-2 plus LAK immunotherapy. JF - British journal of cancer AU - Eggermont, A M AU - Steller, E P AU - Matthews, W AU - Sugarbaker, P H AD - Surgery Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 97 EP - 102 VL - 56 IS - 2 SN - 0007-0920, 0007-0920 KW - Epitopes KW - 0 KW - Interleukin-2 KW - Lymphokines KW - Recombinant Proteins KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Lymphokines -- immunology KW - Animals KW - Cyclophosphamide -- therapeutic use KW - Recombinant Proteins -- metabolism KW - Immunotherapy KW - Recombinant Proteins -- immunology KW - Spleen -- immunology KW - Mice KW - Recombinant Proteins -- therapeutic use KW - Killer Cells, Natural -- immunology KW - Female KW - Cell Line KW - Interleukin-2 -- metabolism KW - Neoplasms, Experimental -- immunology KW - Neoplasms, Experimental -- therapy KW - Interleukin-2 -- therapeutic use KW - Neoplasms, Experimental -- metabolism KW - Interleukin-2 -- immunology KW - Epitopes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81054259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Alloimmune+cells+consume+interleukin-2+and+competitively+inhibit+the+anti-tumour+effects+of+interleukin-2.&rft.au=Eggermont%2C+A+M%3BSteller%2C+E+P%3BMatthews%2C+W%3BSugarbaker%2C+P+H&rft.aulast=Eggermont&rft.aufirst=A&rft.date=1987-08-01&rft.volume=56&rft.issue=2&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=00070920&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-15 N1 - Date created - 1987-12-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Exp Med. 1979 Mar 1;149(3):774-9 [219129] J Immunol. 1978 Sep;121(3):1045-51 [151115] J Exp Med. 1981 May 1;153(5):1360-5 [6454746] J Exp Med. 1981 Aug 1;154(2):262-74 [6790656] J Exp Med. 1982 Apr 1;155(4):1063-74 [6460831] Eur J Immunol. 1982 Mar;12(3):247-9 [6212257] Lancet. 1982 Sep 18;2(8299):662 [6125797] Immunol Rev. 1982;65:99-113 [6214496] J Immunol. 1983 Jan;130(1):222-7 [6600178] J Immunol. 1983 Feb;130(2):527-32 [6217242] Dis Colon Rectum. 1983 Apr;26(4):263-8 [6839898] J Immunol. 1984 Jan;132(1):31-7 [6418801] J Immunol. 1984 Feb;132(2):839-44 [6418812] Science. 1984 Mar 30;223(4643):1412-4 [6367046] J Immunol. 1984 May;132(5):2259-65 [6609193] J Immunol. 1984 Sep;133(3):1371-8 [6205081] Adv Immunol. 1984;35:89-155 [6235727] J Immunol. 1984 Oct;133(4):1769-74 [6236258] Science. 1984 Sep 28;225(4669):1487-9 [6332379] J Immunol. 1984 Dec;133(6):3075-83 [6238093] J Immunol. 1984 Dec;133(6):3333-7 [6436379] J Thorac Cardiovasc Surg. 1984 Nov;88(5 Pt 1):659-62 [6492836] J Immunol. 1985 Jan;134(1):272-9 [3155463] J Immunol. 1985 Jan;134(1):45-50 [3155467] J Biol Response Mod. 1984 Oct;3(5):475-82 [6334135] J Immunol. 1985 Jul;135(1):646-52 [3889158] J Clin Oncol. 1985 May;3(5):698-709 [3998786] J Immunol. 1985 Aug;135(2):1145-52 [2409140] J Immunol. 1985 Aug;135(2):1488-97 [3891854] Cancer Res. 1985 Aug;45(8):3735-41 [3893689] J Immunol. 1985 Sep;135(3):1834-9 [3926886] J Biol Response Mod. 1985 Aug;4(4):377-90 [3875693] J Immunol. 1985 Nov;135(5):2911-3 [3876368] J Immunol. 1985 Nov;135(5):2996-3003 [2931477] J Immunol. 1985 Nov;135(5):3172-7 [3930598] J Immunol. 1985 Nov;135(5):3623-35 [3900213] N Engl J Med. 1985 Dec 5;313(23):1485-92 [3903508] J Immunol. 1986 Mar 1;136(5):1693-9 [2936808] J Immunol. 1986 Jul 1;137(1):341-6 [3486915] Semin Oncol. 1986 Jun;13(2):200-6 [3520827] Clin Exp Immunol. 1972 Feb;10(2):285-96 [5046868] Transplantation. 1980 Feb;29(2):153-8 [6986688] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regulation of interleukin 2 and interleukin 2 receptor gene expression in human T cells: I. Effect of Ca2+-ionophore on phorbol myristate acetate co-stimulated cells. AN - 81015029; 3115657 AB - Human peripheral blood T lymphocytes were treated with phorbol myristate acetate (PMA), an activator of protein kinase C (PKC) activity, and with the calcium ionophore A23187. The resulting accumulation of specific mRNA for interleukin 2 (IL-2) and interleukin 2 receptor (IL-2R), as well as IL-2 secretion and membrane IL-2R expression were examined. At low concentrations (0.1 microM), A23187 synergized maximally with PMA to induce proliferation, to increase IL-2R mRNA levels and the expression of membrane IL-2R, and to produce a low but sufficient accumulation of IL-2 mRNA and IL-2 secretion. A high concentration of A23187 (1.0 microM) did not show any synergism for the accumulation of IL-2R mRNA, membrane IL-2R expression and inhibited the proliferation of PMA co-stimulated T cells. It did, however, induce maximum accumulation of IL-2 mRNA and IL-2 secretion. JF - Clinical and experimental immunology AU - Chopra, R K AU - Nagel, J E AU - Chrest, F J AU - Boto, W M AU - Pyle, R S AU - Dorsey, B AU - McCoy, M AU - Holbrook, N AU - Adler, W H AD - Clinical Immunology Section, National Institute on Aging, Baltimore, Maryland 21224. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 433 EP - 440 VL - 69 IS - 2 SN - 0009-9104, 0009-9104 KW - Interleukin-2 KW - 0 KW - RNA, Messenger KW - Receptors, Immunologic KW - Receptors, Interleukin-2 KW - Calcimycin KW - 37H9VM9WZL KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Humans KW - RNA, Messenger -- analysis KW - Cell Division -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Drug Synergism KW - T-Lymphocytes -- immunology KW - Receptors, Immunologic -- genetics KW - Lymphocyte Activation -- drug effects KW - Interleukin-2 -- biosynthesis KW - Receptors, Immunologic -- analysis KW - Gene Expression Regulation -- drug effects KW - Interleukin-2 -- genetics KW - Calcimycin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81015029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+experimental+immunology&rft.atitle=Regulation+of+interleukin+2+and+interleukin+2+receptor+gene+expression+in+human+T+cells%3A+I.+Effect+of+Ca2%2B-ionophore+on+phorbol+myristate+acetate+co-stimulated+cells.&rft.au=Chopra%2C+R+K%3BNagel%2C+J+E%3BChrest%2C+F+J%3BBoto%2C+W+M%3BPyle%2C+R+S%3BDorsey%2C+B%3BMcCoy%2C+M%3BHolbrook%2C+N%3BAdler%2C+W+H&rft.aulast=Chopra&rft.aufirst=R&rft.date=1987-08-01&rft.volume=69&rft.issue=2&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Clinical+and+experimental+immunology&rft.issn=00099104&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-10 N1 - Date created - 1987-11-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol Methods. 1976;12(3-4):285-8 [1085784] J Immunol. 1978 Jun;120(6):2027-32 [307029] J Immunol. 1979 Oct;123(4):1624-31 [314468] Biochemistry. 1979 Nov 27;18(24):5294-9 [518835] Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5 [6159641] J Immunol. 1981 Nov;127(5):2086-8 [6457861] J Exp Med. 1981 Nov 1;154(5):1455-74 [6975347] Nature. 1982 Jan 7;295(5844):68-71 [6799829] Immunol Commun. 1983;12(2):223-237 [6603416] Anal Biochem. 1983 Jul 1;132(1):6-13 [6312838] J Immunol. 1984 Apr;132(4):1833-6 [6321592] J Immunol. 1984 Jul;133(1):123-8 [6327821] Biochem J. 1984 Jun 1;220(2):345-60 [6146314] Science. 1984 Sep 21;225(4668):1365-70 [6147898] Nature. 1985 Jan 24-30;313(6000):318-20 [3918270] J Exp Med. 1985 Mar 1;161(3):446-56 [3919143] Proc Natl Acad Sci U S A. 1985 May;82(9):2935-9 [3873071] Proc Natl Acad Sci U S A. 1986 Jan;83(2):437-40 [3484551] J Exp Med. 1986 Jun 1;163(6):1405-14 [3086481] J Exp Med. 1987 Jan 1;165(1):157-72 [3098893] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Contaminant and nutrient concentrations of natural ingredient rat and mouse diet used in chemical toxicology studies. AN - 81006926; 3653575 AB - The NIH-07 open formula natural ingredient rat and mouse ration is the standard diet for chemical toxicity and carcinogenicity studies conducted for the National Toxicology Program (NTP). Contaminant and nutrient concentrations were determined in 2 to 94 lots of this diet used in the NTP toxicology studies. All nutrient concentrations were equivalent to or greater than the requirements for rats and mice as set forth by the National Research Council. Aflatoxins, Hg, chlorinated hydrocarbons except methoxychlor, organophosphates except malathion, estrogenic activity, and Salmonella sp. were not present at the detectable levels. Fluorine, As, Cd, Pb, Se, N-nitrosodimethylamine, N-nitrosopyrrolidine, N-nitrosomorpholine, nitrate, nitrite, butylated hydroxyanisole, butylated hydroxytoluene, ethylene dibromide, methoxychlor, malathion, and trypsin inhibitor activity were present at or above the detectable levels. Five lots of diet had nitrosamine content of 100 to 273 ppb and 7 lots had 2.08 to 3.37 ppm of Pb. All other lots of NIH-07 diet used for NTP toxicology studies contained low levels of the contaminants. After determination of the contaminant concentrations in the 94 lots of diet and the contaminant concentrations in natural ingredients used in formulating NIH-07 diet, maximum allowable levels of contaminants were established and a flexible scoring system for acceptability of each lot of diet for chemical toxicology studies was developed. By prescreening ingredients such as fish meal for heavy metals and nitrosamines, and applying the flexible scoring system proposed, more than 95% of the lots of NIH-07 diet produced during the last 3 years had scores of greater than or equal to 95 out of 100 points and were considered acceptable for toxicology studies. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Rao, G N AU - Knapka, J J AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 329 EP - 338 VL - 9 IS - 2 SN - 0272-0590, 0272-0590 KW - Index Medicus KW - Rats KW - Animals KW - Nutritive Value KW - Mice KW - Diet KW - Food Contamination -- analysis KW - Animal Feed -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81006926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Contaminant+and+nutrient+concentrations+of+natural+ingredient+rat+and+mouse+diet+used+in+chemical+toxicology+studies.&rft.au=Rao%2C+G+N%3BKnapka%2C+J+J&rft.aulast=Rao&rft.aufirst=G&rft.date=1987-08-01&rft.volume=9&rft.issue=2&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-02 N1 - Date created - 1987-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analyses of carcinogen-modified oligonucleotides by fast atom bombardment/tandem mass spectrometry. AN - 78069223; 2980329 JF - Rapid communications in mass spectrometry : RCM AU - Dino, J J AU - Guenat, C R AU - Tomer, K B AU - Kaufman, D G AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27713. Y1 - 1987/08// PY - 1987 DA - August 1987 SP - 69 EP - 71 VL - 1 IS - 4 SN - 0951-4198, 0951-4198 KW - Carcinogens KW - 0 KW - Oligonucleotides KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide KW - 55097-80-8 KW - Index Medicus KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide -- analysis KW - Spectrometry, Mass, Fast Atom Bombardment KW - Oligonucleotides -- analysis KW - Carcinogens -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78069223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Analyses+of+carcinogen-modified+oligonucleotides+by+fast+atom+bombardment%2Ftandem+mass+spectrometry.&rft.au=Dino%2C+J+J%3BGuenat%2C+C+R%3BTomer%2C+K+B%3BKaufman%2C+D+G&rft.aulast=Dino&rft.aufirst=J&rft.date=1987-08-01&rft.volume=1&rft.issue=4&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=09514198&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-06 N1 - Date created - 1992-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Dopaminergic modulation of bulbofugal projections in the rat olfactory tubercle. AN - 85211215; pmid-2820257 AB - Neuronal activities following olfactory bulb electrical stimulation were examined before and after administration of dopamine and dopamine antagonist in the rat olfactory tubercle. The inhibitory response to olfactory bulb stimulation was attenuated by systemic haloperidol administration, but the excitatory response to olfactory bulb stimulation rarely was modulated. Topical application of dopamine by iontophoresis extended the duration of inhibition in 56% of the neurons sampled and diminished it in 25%; the excitatory response was modulated in 42% of neurons, most of which were attenuated. These findings suggest that dopamine in the olfactory tubercle could be involved in modulations of neuronal activities related to olfactory transduction. JF - American Journal of Otolaryngology AU - Inokuchi, A AU - Mooney, K E AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1987 SP - 214 EP - 218 VL - 8 IS - 4 SN - 0196-0709, 0196-0709 KW - Rats, Inbred Strains KW - Rats KW - Haloperidol KW - Dopamine KW - Support, U.S. Gov't, P.H.S. KW - Olfactory Pathways KW - Tegmentum Mesencephali KW - Neurons KW - Animal KW - Olfactory Bulb KW - Neural Inhibition KW - Electric Stimulation KW - Male KW - Synaptic Transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85211215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Otolaryngology&rft.atitle=Dopaminergic+modulation+of+bulbofugal+projections+in+the+rat+olfactory+tubercle.&rft.au=Inokuchi%2C+A%3BMooney%2C+K+E%3BSnow%2C+J+B&rft.aulast=Inokuchi&rft.aufirst=A&rft.date=1987-07-01&rft.volume=8&rft.issue=4&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Otolaryngology&rft.issn=01960709&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effect of stimulation of the horizontal limb of the diagonal band on rat olfactory bulb neuronal activity. AN - 85211154; pmid-3631417 AB - Reports suggest that patients with Alzheimer's disease have deficient olfactory sensitivity and disruption of the cholinergic pathways. Elucidation of the cholinergic system in the olfactory bulb is essential to the understanding of this disease for diagnostic and therapeutic advances. Possible cholinergic projection to the olfactory bulb was studied in rats with transected medial forebrain bundles by stimulating the horizontal limb of the diagonal band, which contains cholinergic perikarya. Electrical stimulation of the horizontal limb of the diagonal band evoked negative potentials in the granule cell layer. Neurons in the granule cell layer were excited, and those in the mitral cell layer and external plexiform cell layer showed inhibition, often followed by excitation. These responses were attenuated by the administration of the cholinergic blocker, atropine. The role of cholinergic projection to olfactory bulb neurons is discussed. JF - American Journal of Otolaryngology AU - Inokuchi, A AU - Restrepo, J P AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1987 SP - 205 EP - 210 VL - 8 IS - 4 SN - 0196-0709, 0196-0709 KW - Rats KW - Rats, Inbred Strains KW - Brain Mapping KW - Support, U.S. Gov't, P.H.S. KW - Olfactory Pathways KW - Evoked Potentials KW - Neurons KW - Animal KW - Olfactory Bulb KW - Cholinergic Fibers KW - Central Nervous System UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85211154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Otolaryngology&rft.atitle=Effect+of+stimulation+of+the+horizontal+limb+of+the+diagonal+band+on+rat+olfactory+bulb+neuronal+activity.&rft.au=Inokuchi%2C+A%3BRestrepo%2C+J+P%3BSnow%2C+J+B&rft.aulast=Inokuchi&rft.aufirst=A&rft.date=1987-07-01&rft.volume=8&rft.issue=4&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Otolaryngology&rft.issn=01960709&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Maximal electroshock increases the density of [3H]Ro 5-4864 binding to mouse cerebral cortex. AN - 81019131; 2820550 AB - The effects of chemically and electrically-induced convulsions on the binding of [3H]Ro 5-4864 to peripheral benzodiazepine receptors (PBR) was studied in both peripheral tissues and the central nervous system (CNS). Acute, maximal electroshock (MES) increased the density of PBR in mouse cerebral cortex as evidenced by a 30% increase in the Bmax of this archetypic ligand. These values returned to control levels by 60 minutes after MES treatment. In contrast, thirty and sixty minutes after convulsions induced by Ro 5-4864, strychnine, or pentylenetetrazol, neither the Bmax nor Kd of [3H]Ro 5-4864 binding to mouse cerebral cortical membranes was altered. The increase in [3H]Ro 5-4864 binding to cortex observed 30 minutes after MES was blocked by anticonvulsant doses of phenobarbital, phenytoin and clonazepam. No changes in the characteristics of [3H]Ro 5-4864 binding was observed in cerebellar or hippocampal membranes 30 minutes following acute MES. Further, after long-term MES administration (1 treatment/day, 5 days), no change in PBR density could be detected 30 minutes after the last MES. Finally, while no change in PBR density was noted in the kidneys 30 minutes after the MES, a significant increase in PBR density was seen in the cardiac ventricles. These results demonstrate a selective modulation of PBR density by MES, suggesting that the PBR could be involved in either the generation of seizures or in postictal compensatory processes. JF - Brain research bulletin AU - Basile, A S AU - Weissman, B A AU - Skolnick, P AD - Laboratory of Neuroscience, NIDDK, Bethesda, MD 20892. Y1 - 1987/07// PY - 1987 DA - July 1987 SP - 1 EP - 7 VL - 19 IS - 1 SN - 0361-9230, 0361-9230 KW - Anticonvulsants KW - 0 KW - Benzodiazepinones KW - Convulsants KW - Receptors, GABA-A KW - 4'-chlorodiazepam KW - 2QW0IK1742 KW - Index Medicus KW - Anticonvulsants -- pharmacology KW - Animals KW - Kidney -- metabolism KW - Kinetics KW - Heart Ventricles -- metabolism KW - Convulsants -- pharmacology KW - Brain -- drug effects KW - Binding, Competitive KW - Mice KW - Brain -- metabolism KW - Male KW - Seizures -- chemically induced KW - Cerebral Cortex -- drug effects KW - Cerebral Cortex -- metabolism KW - Benzodiazepinones -- metabolism KW - Receptors, GABA-A -- metabolism KW - Seizures -- metabolism KW - Receptors, GABA-A -- drug effects KW - Electroshock KW - Benzodiazepinones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81019131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research+bulletin&rft.atitle=Maximal+electroshock+increases+the+density+of+%5B3H%5DRo+5-4864+binding+to+mouse+cerebral+cortex.&rft.au=Basile%2C+A+S%3BWeissman%2C+B+A%3BSkolnick%2C+P&rft.aulast=Basile&rft.aufirst=A&rft.date=1987-07-01&rft.volume=19&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Brain+research+bulletin&rft.issn=03619230&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-20 N1 - Date created - 1987-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast. AN - 81016817; 3308449 AB - Two benzo[a]pyrene-resistant mutant clones (c1 and c37) of the mouse hepatoma Hepa-1 wild-type (wt) cell line were examined for their lack of P(1)450 [aryl hydrocarbon (benzo[a]pyrene) hydroxylase (AHH)] activity. From lambda gt11 cDNA libraries, the nearly full-length P(1)450 cDNAs of wt, c1 and c37 were isolated and sequenced. The c1 cDNA was found to have a single mutation leading to premature termination of the protein after Asn-414; a rapidly migrating band corresponding to this truncated protein was found on Western immunoblots. The c37 cDNA was found to have two point mutations, leading to Leu-118----Arg-118 and Arg-245----Pro-245, but otherwise to encode the normal (524-residue) protein; the mature protein was confirmed by Western blot analysis. P(1)450 cDNA from wt, c1 and c37 and chimeric cDNAs between wt and c37 were inserted into the expression vector pAAH5 and expressed in Saccharomyces cerevisiae strain 50.L4. The Leu-118----Arg-118 mutation alone was found to have negligible effect on AHH activity, while the Arg-245----Pro-245 mutation alone leads to a 2- to 3-fold decrease in enzyme activity. The two mutations together totally abrogate AHH activity. The biologic mutant c37 provides the first evidence for the importance of Arg-245, and the complementary function of Leu-118, in normal P(1)450 enzymic function. This alteration in a single amino acid from arginine to proline might block electron flow directly, or change secondary structure of the protein, such that normal monooxygenation of benzo[a]pyrene cannot occur. JF - The EMBO journal AU - Kimura, S AU - Smith, H H AU - Hankinson, O AU - Nebert, D W AD - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/07// PY - 1987 DA - July 1987 SP - 1929 EP - 1933 VL - 6 IS - 7 SN - 0261-4189, 0261-4189 KW - Benzo(a)pyrene KW - 3417WMA06D KW - DNA KW - 9007-49-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Index Medicus KW - Saccharomyces cerevisiae -- genetics KW - Animals KW - Base Sequence KW - Molecular Sequence Data KW - Drug Resistance KW - Mice KW - Amino Acid Sequence KW - Plasmids KW - Benzo(a)pyrene -- pharmacology KW - Liver Neoplasms, Experimental -- genetics KW - Cytochrome P-450 Enzyme System -- genetics KW - DNA -- metabolism KW - Genes -- drug effects KW - Transcription, Genetic KW - Aryl Hydrocarbon Hydroxylases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81016817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+EMBO+journal&rft.atitle=Analysis+of+two+benzo%5Ba%5Dpyrene-resistant+mutants+of+the+mouse+hepatoma+Hepa-1+P%281%29450+gene+via+cDNA+expression+in+yeast.&rft.au=Kimura%2C+S%3BSmith%2C+H+H%3BHankinson%2C+O%3BNebert%2C+D+W&rft.aulast=Kimura&rft.aufirst=S&rft.date=1987-07-01&rft.volume=6&rft.issue=7&rft.spage=1929&rft.isbn=&rft.btitle=&rft.title=The+EMBO+journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-16 N1 - Date created - 1987-11-16 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - Y00071; GENBANK N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1969 Dec;64(4):1188-94 [4318345] Adv Enzymol Relat Areas Mol Biol. 1987;60:35-87 [3310532] Int J Cancer. 1972 Mar 15;9(2):435-51 [5064941] Biochem Pharmacol. 1973 Nov 1;22(21):2766-9 [4357894] Dev Biol. 1973 Nov;35(1):83-96 [4362668] J Biol Chem. 1976 Aug 25;251(16):4936-46 [956169] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] Methods Enzymol. 1978;52:226-40 [672631] Proc Natl Acad Sci U S A. 1979 Jan;76(1):373-6 [106390] J Biol Chem. 1979 Nov 25;254(22):11636-48 [500663] Biochemistry. 1979 Nov 27;18(24):5294-9 [518835] Mutat Res. 1980 Jan;77(1):55-63 [6767185] Biochim Biophys Acta. 1980;613(1):52-61 [6990989] J Biol Chem. 1980 Dec 10;255(23):11415-22 [6254968] Eur J Biochem. 1981 Apr;115(3):585-94 [7238523] Somatic Cell Genet. 1981 Jul;7(4):373-88 [6269236] J Biol Chem. 1982 Jun 10;257(11):6402-7 [6896205] Pharmacol Rev. 1982 Jun;34(2):189-222 [6287505] Cancer Res. 1982 Dec;42(12):4875-917 [6814745] Proc Natl Acad Sci U S A. 1983 Mar;80(5):1194-8 [6219389] J Biol Chem. 1983 Mar 25;258(6):3523-7 [6300048] Drug Metab Dispos. 1983 Jan-Feb;11(1):1-4 [6132787] Anal Biochem. 1983 Feb 15;129(1):216-23 [6305233] Methods Enzymol. 1983;101:192-201 [6310322] Somatic Cell Genet. 1983 Jul;9(4):497-514 [6623311] J Biol Chem. 1984 May 10;259(9):5400-2 [6715350] Mol Pharmacol. 1984 Jul;26(1):117-21 [6749129] J Biol Chem. 1984 Sep 10;259(17):10705-13 [6547952] Gene. 1984 Sep;29(3):281-92 [6548461] J Biol Chem. 1985 Feb 10;260(3):1790-5 [3968086] Annu Rev Genet. 1984;18:131-71 [6084979] Prog Nucleic Acid Res Mol Biol. 1984;31:315-462 [6397774] Mol Cell Biol. 1985 Apr;5(4):698-704 [3990691] DNA. 1985 Jun;4(3):203-10 [3159557] CRC Crit Rev Biochem. 1986;19(3):247-305 [3512165] Microbiol Rev. 1986 Sep;50(3):244-58 [3534536] DNA. 1987 Feb;6(1):1-11 [3829886] Annu Rev Biochem. 1987;56:945-93 [3304150] Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408-12 [4504350] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cytogenetic methodologies for gene mapping and comparative analyses in mammalian cell culture systems. AN - 78059091; 3507390 AB - Presented here are the detailed methods employed in our laboratory for gene mapping and cytogenetic analyses in human beings, in the domestic cat, and in other mammalian species. Induced in the procedures are: 1) establishment of primary fibroblast and lymphoid cell cultures; 2) heterologous cell fusion for production of rapidly proliferating cell hybrids; 3) cellular transformation of primary fibroblasts using an oncogenic retrovirus; 4) cell synchronization for high-resolution banding of promethaphase chromosomes; 5) chromosome-banding procedures, including G-banding, alkaline G-11, and Q-banding; and 6) in situ hybridization of radiolabeled molecular clones to metaphase chromosomes for regional gene localization. JF - Gene analysis techniques AU - Modi, W S AU - Nash, W G AU - Ferrari, A C AU - O'Brien, S J AD - Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701-1013. PY - 1987 SP - 75 EP - 85 VL - 4 IS - 4 SN - 0735-0651, 0735-0651 KW - Index Medicus KW - Karyotyping KW - Protein Biosynthesis KW - Animals KW - Chromosome Banding KW - Cells, Cultured KW - Humans KW - Hybrid Cells -- cytology KW - Fibroblasts -- cytology KW - Male KW - Lymphocytes -- cytology KW - Chromosome Mapping KW - Cytogenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78059091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+analysis+techniques&rft.atitle=Cytogenetic+methodologies+for+gene+mapping+and+comparative+analyses+in+mammalian+cell+culture+systems.&rft.au=Modi%2C+W+S%3BNash%2C+W+G%3BFerrari%2C+A+C%3BO%27Brien%2C+S+J&rft.aulast=Modi&rft.aufirst=W&rft.date=1987-07-01&rft.volume=4&rft.issue=4&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Gene+analysis+techniques&rft.issn=07350651&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-28 N1 - Date created - 1989-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Overview of human cells in genetic research: altered phenotypes in human cells caused by transferred genes. AN - 78034452; 3331832 JF - Somatic cell and molecular genetics AU - Brash, D E AU - Mark, G E AU - Farrell, M P AU - Harris, C C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/07// PY - 1987 DA - July 1987 SP - 429 EP - 440 VL - 13 IS - 4 SN - 0740-7750, 0740-7750 KW - Index Medicus KW - Phenotype KW - Humans KW - Transfection KW - Genetic Engineering -- methods KW - Genetic Engineering -- trends KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78034452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Somatic+cell+and+molecular+genetics&rft.atitle=Overview+of+human+cells+in+genetic+research%3A+altered+phenotypes+in+human+cells+caused+by+transferred+genes.&rft.au=Brash%2C+D+E%3BMark%2C+G+E%3BFarrell%2C+M+P%3BHarris%2C+C+C&rft.aulast=Brash&rft.aufirst=D&rft.date=1987-07-01&rft.volume=13&rft.issue=4&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Somatic+cell+and+molecular+genetics&rft.issn=07407750&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-13 N1 - Date created - 1988-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Substance abuse and women's health. AN - 77846249; 3120220 AB - The prevalence of illicit drug use is higher among men than women, but new drug use occurs at twice the rate for females as for males. Recent data from emergency rooms and medical examiners support this pattern, but females were more likely than males to report use of tranquilizers, antidepressants, and some nonbarbiturate sedatives. Recent data show that men outnumbered women in drug treatment admissions for all drugs except tranquilizers. However, the 1984 National Institute of Mental Health Epidemiologic Catchment Area Survey shows drug abuse and dependence to be the second most commonly reported disorder for women. Smoking is the most common form of drug dependence in our society, and it has a major impact on women's health. Lung cancer is now the leading cause of cancer deaths among women. Smoking poses a special risk of coronary heart disease for women using oral contraceptives. The incidence of emphysema among women has also risen sharply. Smoking during pregnancy carries special, serious risks. Research strongly suggests that the use of marijuana during pregnancy carries significant risks, including low birth weights and fetal abnormalities. Opiate addiction among women is uncommon, but it carries disproportionate health risks for these women and their offspring; infants born of addicted mothers have much higher morbidity and mortality rates than infants in general. Acquired immune deficiency syndrome is a grave risk to women using intravenous drugs and to their children. There are a number of health problems associated with psychoactive drug use among elderly women. In addition to research, the National Institute on Drug Abuse has focused a number of its activities on the special problems and needs of women. The Institute is collaborating with the health care community to place increased emphasis on prevention and treatment services for women and is working with organizations in the public and private sector to ensure that current information about drug use is effectively disseminated. JF - Public health reports (Washington, D.C. : 1974) AU - Johnson, E M AD - National Institute on Drug Abuse, Alcohol, Drug Abuse, and Mental Health Administration, Rockville, MD. PY - 1987 SP - 42 EP - 48 VL - 102 IS - 4 Suppl SN - 0033-3549, 0033-3549 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Opioid-Related Disorders -- epidemiology KW - Opioid-Related Disorders -- complications KW - Risk Factors KW - Humans KW - Adult KW - Child KW - Research KW - Adolescent KW - Smoking -- epidemiology KW - Male KW - Female KW - Pregnancy KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77846249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Substance+abuse+and+women%27s+health.&rft.au=Johnson%2C+E+M&rft.aulast=Johnson&rft.aufirst=E&rft.date=1987-07-01&rft.volume=102&rft.issue=4+Suppl&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-23 N1 - Date created - 1987-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of cytolysin activity in large granular lymphocyte granules by lipids: evidence for a membrane insertion mechanism of lysis. AN - 81034480; 3657801 AB - The ability of various compounds to inhibit the lytic activity of purified cytoplasmic granules from LGL tumors was tested. The lytic activity of granule cytolysin was modestly inhibited by inorganic phosphate, and various monophosphoesters, with I50 values in the range of 8-20 mM. Among monophosphoesters, choline phosphate was exceptionally potent, with an I50 of 1.4 mM. In contrast to the inhibition by phosphate esters, the parent compounds such as neutral sugars, glycerol, and choline, showed no detectable inhibition at 50 mM. A lysolipid bearing a short aliphatic chain and some detergents were inhibitory with I50 values in the range of 1 mM. Lysolipids with longer aliphatic chains, phospholipids as liposomes, and related lipid compounds were found to display potent inhibition of the hemolytic activity of LGL granule cytolysin, with I50 values in the range of 0.2-30 microM. Soluble globular proteins inhibited LGL granule cytolysin hemolytic activity with I50 of 0.07-0.4 mg/ml. However, lipoproteins were 2-3 orders of magnitude more potent inhibitors, with L50 values of less than 1 microgram/ml. The observed potent inhibition by lipid compounds lends support to a model of the lytic action of granule cytolysin in which soluble cytolysin molecules insert into the membrane lipid bilayer during the course of the lytic event. JF - Molecular immunology AU - Yue, C C AU - Reynolds, C W AU - Henkart, P A AD - Immunology Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/06// PY - 1987 DA - June 1987 SP - 647 EP - 653 VL - 24 IS - 6 SN - 0161-5890, 0161-5890 KW - Cytotoxins KW - 0 KW - Lipids KW - Lipoproteins KW - Phosphates KW - Index Medicus KW - Rats KW - Lipoproteins -- pharmacology KW - Animals KW - Cell Membrane -- immunology KW - Neoplasms, Experimental -- immunology KW - Phosphates -- pharmacology KW - Lymphocytes -- immunology KW - Lipids -- pharmacology KW - Cytoplasmic Granules -- immunology KW - Cytotoxins -- antagonists & inhibitors KW - Cytotoxicity, Immunologic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81034480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+immunology&rft.atitle=Inhibition+of+cytolysin+activity+in+large+granular+lymphocyte+granules+by+lipids%3A+evidence+for+a+membrane+insertion+mechanism+of+lysis.&rft.au=Yue%2C+C+C%3BReynolds%2C+C+W%3BHenkart%2C+P+A&rft.aulast=Yue&rft.aufirst=C&rft.date=1987-06-01&rft.volume=24&rft.issue=6&rft.spage=647&rft.isbn=&rft.btitle=&rft.title=Molecular+immunology&rft.issn=01615890&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-09 N1 - Date created - 1987-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Radioimmunotherapy of athymic mice bearing human colon carcinomas with monoclonal antibody B72.3: histological and autoradiographic study of effects on tumors and normal organs. AN - 81011041; 2820742 AB - Monoclonal antibody (MAb) B72.3 has been linked successfully to several radionuclides forming stable complexes and analyzed in vitro and in vivo without significant loss of its immunoreactivity. Previous studies have demonstrated that radioiodinated B72.3 can selectively bind to human colorectal carcinomas grown in athymic mice. The same successful localization has been obtained more recently in clinical trials in patients with metastatic colorectal carcinomas. The high degree of selective binding of this MAb has led us to investigate its potential as a radioimmunotherapeutic agent. Athymic mice bearing human colon carcinoma xenografts were injected with either 300 or 500 microCi of 131I-B72.3 IgG to assess the effect o the radiolabeled MAb on the tumor growth as well as potential toxic side effects in vital organs. In mice treated with the 131I-B72.3 IgG, a marked inhibition of the growth of the human colon carcinoma xenografts was noticed in comparison with control mice injected with PBS or control mice that received unlabeled B72.3 IgG. The tumors from these control mice weighed 2.7 to 3.7 times more than the tumors from the treated mice at 17 days post-inoculation of the radiolabeled MAb. Autoradiographic studies demonstrated a heterogeneous distribution of radioactivity throughout the tumor mass at 11 days post-administration of MAb. With time, the periphery of the tumor contained significantly less radioactivity than the medial areas composed of predominantly nonviable tissue; these findings suggest that the more biologically active peripheral tumor zones, with higher mitotic rates, could have partially escaped the radiation effect of the single dose administered. The tumor cells could have continued dividing when the levels of circulating radiolabeled monoclonal antibody had decreased. Toxicity was readily evident in the mice injected with the high-dose regimen (500 microCi), with confirmed bone marrow aplasia that proved lethal for 2 of 10 animals. The lower dose (300 microCi) resulted in a bone marrow suppression of approx. 50% of the cells, which proved to be non-lethal. The tumors in the treated mice showed extensive necrosis caused by the lethal dose of 131I-B72.3 that irreversibly damaged the cells. Radiation-induced terminal differentiation of cells was also found as manifested by the drastically decreased mitotic count (0-2 vs. 12-14 per 10 high power fields seen in control tumors) in treated animals. JF - European journal of cancer & clinical oncology AU - Esteban, J M AU - Schlom, J AU - Mornex, F AU - Colcher, D AD - Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987/06// PY - 1987 DA - June 1987 SP - 643 EP - 655 VL - 23 IS - 6 SN - 0277-5379, 0277-5379 KW - Antibodies, Monoclonal KW - 0 KW - Iodine Radioisotopes KW - Index Medicus KW - Radiation Injuries, Experimental -- pathology KW - Animals KW - Necrosis KW - Spleen -- radiation effects KW - Humans KW - Mice, Nude KW - Mice KW - Bone Marrow -- radiation effects KW - Autoradiography KW - Female KW - Cell Line KW - Iodine Radioisotopes -- therapeutic use KW - Adenocarcinoma, Mucinous -- radiotherapy KW - Colonic Neoplasms -- radiotherapy KW - Colonic Neoplasms -- pathology KW - Adenocarcinoma, Mucinous -- pathology KW - Antibodies, Monoclonal -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81011041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+%26+clinical+oncology&rft.atitle=Radioimmunotherapy+of+athymic+mice+bearing+human+colon+carcinomas+with+monoclonal+antibody+B72.3%3A+histological+and+autoradiographic+study+of+effects+on+tumors+and+normal+organs.&rft.au=Esteban%2C+J+M%3BSchlom%2C+J%3BMornex%2C+F%3BColcher%2C+D&rft.aulast=Esteban&rft.aufirst=J&rft.date=1987-06-01&rft.volume=23&rft.issue=6&rft.spage=643&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+%26+clinical+oncology&rft.issn=02775379&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-10-29 N1 - Date created - 1987-10-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The role of glutathione in radiation and drug induced cytotoxicity. AN - 80998643; 3307879 AB - The cellular response to radiation and various chemotherapy drugs, whose mechanism in part includes production of free radicals or DNA damage, may be altered by modification of cellular thiols. The recent introduction of agents which either inhibit glutathione (GSH) biosynthesis (buthionine sulfoximine, BSO) or stimulate GSH synthesis (oxothiazolidine-4-carboxylate, OTZ) has enabled detailed studies assessing the role of GSH in the radiation and chemotherapy response. GSH depletion by BSO has resulted in radiosensitization of both aerobic and hypoxic cells, with some discrepancy among laboratories as to the extent of sensitization of hypoxic cells. GSH elevation (by approximately 200% of control) has resulted in modest protection of aerobic and hypoxic cells. GSH has been shown to play an important role in the radiosensitization of hypoxic cells using nitroimidazoles. The extent of nitroimidazole hypoxic radiosensitization has recently been shown to depend on intracellular GSH levels. Recent findings that some human tumour cell lines, as opposed to rodent cell lines, are high in cellular GSH have prompted a need to evaluate in vivo, GSH levels in human tumours. Possible roles of GSH in the chemotherapy response include: (1) detoxification of H2O2 and/or organoperoxides through GSH peroxidase, (2) non-catalyzed nucleophilic reaction of GSH and drug, (3) binding of the drug with GSH catalyzed by GSH transferase, and (4) activation of certain drugs to toxic species by GSH. The role of GSH as it relates to the various topics mentioned above is discussed with emphasis on direction for future studies. JF - The British journal of cancer. Supplement AU - Mitchell, J B AU - Russo, A AD - Radiobiology Section, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987/06// PY - 1987 DA - June 1987 SP - 96 EP - 104 VL - 8 SN - 0306-9443, 0306-9443 KW - Antineoplastic Agents KW - 0 KW - Nitroimidazoles KW - Radiation-Sensitizing Agents KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Animals KW - Radiation-Sensitizing Agents -- pharmacology KW - Humans KW - Antineoplastic Agents -- therapeutic use KW - Nitroimidazoles -- therapeutic use KW - Cricetinae KW - Cell Survival -- drug effects KW - Glutathione -- metabolism KW - Cell Survival -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80998643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+cancer.+Supplement&rft.atitle=The+role+of+glutathione+in+radiation+and+drug+induced+cytotoxicity.&rft.au=Mitchell%2C+J+B%3BRusso%2C+A&rft.aulast=Mitchell&rft.aufirst=J&rft.date=1987-06-01&rft.volume=8&rft.issue=&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+cancer.+Supplement&rft.issn=03069443&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-10-29 N1 - Date created - 1987-10-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Radiat Oncol Biol Phys. 1984 Oct;10(10):1975-85 [6490426] Cancer Res. 1984 Nov;44(11):5427-31 [6488194] Arch Biochem Biophys. 1985 Jun;239(2):538-48 [4004275] J Biol Chem. 1985 Jul 15;260(14):8312-5 [3159728] Radiat Res. 1985 Aug;103(2):232-9 [4023177] Biochem Pharmacol. 1986 Jan 1;35(1):111-5 [3940521] Cancer Res. 1986 Feb;46(2):735-9 [3940639] Cancer Res. 1986 Jun;46(6):2845-8 [2421885] Int J Radiat Oncol Biol Phys. 1986 Jul;12(7):1143-6 [2943712] Int J Radiat Oncol Biol Phys. 1986 Jul;12(7):1151-5 [3744933] Int J Radiat Oncol Biol Phys. 1986 Jul;12(7):1191-3 [3744939] Int J Radiat Oncol Biol Phys. 1986 Aug;12(8):1347-54 [3531114] Int J Radiat Oncol Biol Phys. 1986 Sep;12(9):1627-35 [2944860] Radiat Res. 1986 Dec;108(3):238-50 [3797633] Nature. 1960 May 7;186:485-7 [14403470] Cancer Treat Rep. 1985 Nov;69(11):1293-6 [4092192] Int J Radiat Biol Relat Stud Phys Chem Med. 1972 Sep;22(3):257-68 [4343885] Int J Radiat Oncol Biol Phys. 1979 Sep;5(9):1519-21 [94054] Proc Natl Acad Sci U S A. 1981 Dec;78(12):7492-6 [6950392] Science. 1982 Aug 6;217(4559):544-5 [7089580] Proc Natl Acad Sci U S A. 1982 Oct;79(20):6246-9 [6959113] Cancer Res. 1983 Jul;43(7):3175-81 [6850627] Radiat Res. 1983 Nov;96(2):422-8 [6647769] Int J Radiat Biol Relat Stud Phys Chem Med. 1983 Nov;44(5):489-95 [6605951] Fundam Appl Toxicol. 1983 Jul-Aug;3(4):200-8 [6354819] Cancer Treat Rep. 1984 Jan;68(1):291-302 [6362869] Int J Radiat Oncol Biol Phys. 1984 Mar;10(3):425-9 [6231272] Int J Radiat Oncol Biol Phys. 1984 Aug;10(8):1243-7 [6469745] Int J Radiat Oncol Biol Phys. 1984 Aug;10(8):1341-5 [6540764] J Natl Cancer Inst. 1985 Jan;74(1):151-7 [3155814] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Electron spin resonance studies of the free radical metabolites of toxic chemicals. AN - 80998549; 2820458 JF - The British journal of cancer. Supplement AU - Mason, R P AU - Stolze, K AU - Morehouse, K M AD - Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, N.C. 27709. Y1 - 1987/06// PY - 1987 DA - June 1987 SP - 163 EP - 171 VL - 8 SN - 0306-9443, 0306-9443 KW - Cyclic N-Oxides KW - 0 KW - Free Radicals KW - Nitrogen Oxides KW - Porphyrins KW - Acetaminophen KW - 362O9ITL9D KW - phenyl-N-tert-butylnitrone KW - 3I91332OPG KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Index Medicus KW - Rats KW - Animals KW - Porphyrins -- metabolism KW - Nitrogen Oxides -- metabolism KW - Carbon Tetrachloride -- metabolism KW - Liver -- metabolism KW - Acetaminophen -- metabolism KW - Electron Spin Resonance Spectroscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80998549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+cancer.+Supplement&rft.atitle=Electron+spin+resonance+studies+of+the+free+radical+metabolites+of+toxic+chemicals.&rft.au=Mason%2C+R+P%3BStolze%2C+K%3BMorehouse%2C+K+M&rft.aulast=Mason&rft.aufirst=R&rft.date=1987-06-01&rft.volume=8&rft.issue=&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+cancer.+Supplement&rft.issn=03069443&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-10-29 N1 - Date created - 1987-10-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Pharmacol. 1986 May;29(5):484-8 [3010076] J Biol Chem. 1986 Apr 15;261(11):5023-8 [3007487] Chem Biol Interact. 1986 Nov;60(2):115-27 [3024853] Proc Natl Acad Sci U S A. 1986 Oct;83(19):7499-502 [3463979] Fed Proc. 1986 Sep;45(10):2493-9 [3017768] Drug Metab Rev. 1983;14(5):1023-53 [6418501] J Biol Chem. 1982 May 10;257(9):5050-5 [6279657] Pharmacol Rev. 1981 Dec;33(4):189-211 [6803257] Biochem Biophys Res Commun. 1982 Jun 30;106(4):1119-25 [6288039] Mol Pharmacol. 1982 Sep;22(2):239-42 [6292686] FEBS Lett. 1983 Aug 22;160(1-2):191-4 [6350040] J Biol Chem. 1983 Dec 25;258(24):14920-5 [6317679] J Biol Chem. 1984 May 10;259(9):5606-11 [6325443] Methods Enzymol. 1984;105:416-22 [6328195] Biochem Pharmacol. 1984 Sep 15;33(18):2933-6 [6089841] Biochem Biophys Res Commun. 1984 Nov 30;125(1):109-15 [6095833] J Biol Chem. 1985 Apr 10;260(7):4003-6 [2984193] Biochem Pharmacol. 1985 Aug 15;34(16):3005-8 [2992528] J Biol Chem. 1985 Sep 25;260(21):11446-50 [2995335] J Biol Chem. 1986 Feb 5;261(4):1642-8 [3003079] Environ Health Perspect. 1985 Dec;64:127-37 [3007084] Environ Health Perspect. 1985 Dec;64:151-70 [3007086] Environ Health Perspect. 1985 Dec;64:85-101 [3007102] J Biol Chem. 1986 Apr 5;261(10):4542-8 [3007463] Fed Proc. 1986 Sep;45(10):2471-6 [3017765] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of pretreatment with inducers of hepatic mixed function oxidases on DNA repair elicited by various compounds in hepatocytes from adult and neonatal rats. AN - 78061987; 3507252 AB - Studies were conducted to assess the effects of inducers of hepatic mixed function oxidases on DNA repair responses to 13 different genotoxic agents in hepatocytes from adult male mice. Phenobarbital pretreatment increased DNA repair elicited by diethylnitrosamine but had no effect on responses to the other compounds. Pretreatment with p,p'-dichlorodiphenyltrichlorethane, 3-methyl-cholanthrene or beta-naphthoflavone induced the DNA repair responses to a variety of activation-dependent carcinogens. DNA repair responses to the direct-acting alkylating agents methyl methanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine were not increased by any of the pretreatments, which indicated that the pretreatment-related enhancement of responses to the other compounds was due to induction of their metabolic activation. Taken together, the findings suggest that Aroclor, or other pretreatments, may increase the sensitivity of the hepatocyte DNA repair assay for detecting the genotoxicity of certain compounds; however, the potential benefit may be limited due to specific features of the assay. In contrast, Aroclor pretreatment did not produce any enhancement of in vivo DNA repair elicited by dimethylnitrosamine, diethylnitrosamine, o-aminoazotoluene, 2-acetylaminofluorene, 3-methylcholanthrene or aflatoxin B1, and thus does not appear to be useful for improving the sensitivity of the in vivo/in vitro assay. Whereas the amount of DNA repair produced by dimethylnitrosamine was not increased by classical inducers of liver microsomal enzymes, pretreatment with pyrazole greatly augmented in vitro and in vivo DNA repair responses to dimethylnitrosamine; responses to diethylnitrosamine were increased to a lesser degree by pyrazole pretreatment. The effects of lactational exposure to enzyme inducing agents on DNA repair in neonatal hepatocytes was also investigated. JF - Cell biology and toxicology AU - Kornbrust, D AU - Dietz, D AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. Y1 - 1987/06// PY - 1987 DA - June 1987 SP - 143 EP - 164 VL - 3 IS - 2 SN - 0742-2091, 0742-2091 KW - Aroclors KW - 0 KW - Benzoflavones KW - Carcinogens KW - Methylcholanthrene KW - 56-49-5 KW - beta-Naphthoflavone KW - 6051-87-2 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - DDT KW - CIW5S16655 KW - Mixed Function Oxygenases KW - EC 1.- KW - Index Medicus KW - Rats KW - Animals KW - Aroclors -- pharmacology KW - 2-Acetylaminofluorene -- pharmacology KW - Methylcholanthrene -- pharmacology KW - In Vitro Techniques KW - Enzyme Induction KW - DDT -- pharmacology KW - Male KW - Female KW - Benzoflavones -- pharmacology KW - Liver -- enzymology KW - DNA Repair KW - Mixed Function Oxygenases -- biosynthesis KW - Carcinogens -- pharmacokinetics KW - Liver -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78061987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+biology+and+toxicology&rft.atitle=Effects+of+pretreatment+with+inducers+of+hepatic+mixed+function+oxidases+on+DNA+repair+elicited+by+various+compounds+in+hepatocytes+from+adult+and+neonatal+rats.&rft.au=Kornbrust%2C+D%3BDietz%2C+D&rft.aulast=Kornbrust&rft.aufirst=D&rft.date=1987-06-01&rft.volume=3&rft.issue=2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Cell+biology+and+toxicology&rft.issn=07422091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-01 N1 - Date created - 1989-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Allergy to animals: a laboratory animal science perspective. AN - 81038537; 3477687 JF - New England and regional allergy proceedings AU - Held, J R AD - Division of Research Services, National Institutes of Health, Bethesda, MD. PY - 1987 SP - 179 EP - 180 VL - 8 IS - 3 SN - 0742-2814, 0742-2814 KW - Index Medicus KW - Animals KW - Humans KW - Occupational Diseases -- immunology KW - Hypersensitivity -- etiology KW - Animals, Laboratory UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81038537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+England+and+regional+allergy+proceedings&rft.atitle=Allergy+to+animals%3A+a+laboratory+animal+science+perspective.&rft.au=Held%2C+J+R&rft.aulast=Held&rft.aufirst=J&rft.date=1987-05-01&rft.volume=8&rft.issue=3&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=New+England+and+regional+allergy+proceedings&rft.issn=07422814&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-06 N1 - Date created - 1987-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol-related problems of children of heavy-drinking parents. AN - 81021810; 3657169 AB - Alcohol-related problems that are experienced by sons and daughters of heavy-drinking parents (either father or mother) are examined using data from a 1978 household sample of employed adults in metropolitan Detroit. Adult children with heavy-drinking parents were found to have a higher percentage of dependent problem drinking than those without heavy-drinking parents. Also, adult children with low status (blue-collar) occupations were found to have a higher percentage of dependent problem drinking than those with high status (white-collar) occupations. Although it was not possible to disentangle the genetic processes from the social processes in this study, the results support the hypothesis that having both heavy-drinking parents and low occupational status places sons and daughters at elevated risk for alcohol-related problems. Implications for future epidemiological studies are discussed. JF - Journal of studies on alcohol AU - Parker, D A AU - Harford, T C AD - Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852. Y1 - 1987/05// PY - 1987 DA - May 1987 SP - 265 EP - 268 VL - 48 IS - 3 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Risk Factors KW - Humans KW - Parents KW - Occupations KW - Alcohol Drinking KW - Male KW - Female KW - Social Class KW - Alcoholism -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81021810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Alcohol-related+problems+of+children+of+heavy-drinking+parents.&rft.au=Parker%2C+D+A%3BHarford%2C+T+C&rft.aulast=Parker&rft.aufirst=D&rft.date=1987-05-01&rft.volume=48&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-18 N1 - Date created - 1987-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pulsatile tinnitus. AN - 85184419; pmid-3550339 AB - Tinnitus is a frequent presenting symptom. Tinnitus that is rhythmic and synchronous with the patient's heartbeat is rare. Pulsatile tinnitus may be the only symptom of life-threatening and treatable diseases. The presence of hearing loss or vertigo focuses the diagnostic evaluation. The cause of pulsatile tinnitus may be found on otoscopic examination. Audiologic assessment and enhanced computed tomography often contribute to the diagnosis. Increased intracranial pressure should be excluded with a fundoscopic examination. Arteriography is required to diagnose life-threatening and treatable lesions in the presence of normal otoscopy, audiologic assessment, and enhanced computed tomography. JF - The Laryngoscope AU - Levine, S B AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1987 SP - 401 EP - 406 VL - 97 IS - 4 SN - 0023-852X, 0023-852X KW - Human KW - Adult KW - Middle Age KW - Case Report KW - Tinnitus KW - Female KW - Pulse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85184419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Pulsatile+tinnitus.&rft.au=Levine%2C+S+B%3BSnow%2C+J+B&rft.aulast=Levine&rft.aufirst=S&rft.date=1987-04-01&rft.volume=97&rft.issue=4&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Projections from the ventral tegmental area to the olfactory tubercle in the rat. AN - 85204463; pmid-3120089 AB - The projection between the ventral tegmental area (VTA) and the olfactory tubercle (OT) was examined electrophysiologically in the rat. Stimulation of the olfactory bulb (OB) determined if the OT neurons were olfactory-related. Ipsilateral VTA stimulation produced a change in neuronal activity in 77% of the neurons tested, with 41% being inhibited, 24% excited, and 12% had mixed response. Contralateral VTA stimulation produced changes in only 38%. Intravenous administration of haloperidol was used in examination of the role of dopamine in this neural connection. The results suggest that the VTA-induced inhibitory response on OT neurons is mediated by dopamine, whereas excitatory responses are not. The VTA inhibitory influence projects primarily to olfactory-related neurons, since 60% of olfactory-related OT neurons were inhibited--as compared to 34% of non-olfactory-related neurons. This study documents electrophysiologically the VTA-OT connection and suggests that the dopaminergic input may modulate olfactory information projected to the OT from the OB. It also supports the concept that the OT acts as an integration center in central olfactory processing. JF - Otolaryngology--Head and Neck Surgery AU - Mooney, K E AU - Inokuchi, A AU - Snow, J B AU - Kimmelman, C P AD - Department of Otorhinolaryngology and Human Communication, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.; National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1987 SP - 151 EP - 157 VL - 96 IS - 2 SN - 0194-5998, 0194-5998 KW - Haloperidol KW - Rats KW - Rats, Inbred Strains KW - Dopamine KW - Support, U.S. Gov't, P.H.S. KW - Tegmentum Mesencephali KW - Neurons KW - Animal KW - Olfactory Bulb KW - Electrophysiology KW - Electric Stimulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85204463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Projections+from+the+ventral+tegmental+area+to+the+olfactory+tubercle+in+the+rat.&rft.au=Mooney%2C+K+E%3BInokuchi%2C+A%3BSnow%2C+J+B%3BKimmelman%2C+C+P&rft.aulast=Mooney&rft.aufirst=K&rft.date=1987-02-01&rft.volume=96&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Mechanism of specific transplantation tolerance induction by vascular allografts across a class I difference in miniature swine. AN - 78062218; 2978932 JF - Transplantation proceedings AU - Kortz, E O AU - Sachs, D H AD - Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Y1 - 1987/02// PY - 1987 DA - February 1987 SP - 861 EP - 863 VL - 19 IS - 1 Pt 1 SN - 0041-1345, 0041-1345 KW - Histocompatibility Antigens Class I KW - 0 KW - Index Medicus KW - Swine KW - Animals KW - Histocompatibility Testing KW - Haplotypes KW - Lymphocyte Culture Test, Mixed KW - Cytotoxicity Tests, Immunologic KW - Transplantation, Homologous KW - Major Histocompatibility Complex KW - Transplantation, Autologous KW - Swine, Miniature KW - Immune Tolerance KW - T-Lymphocytes -- immunology KW - Kidney Transplantation -- immunology KW - Histocompatibility Antigens Class I -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78062218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation+proceedings&rft.atitle=Mechanism+of+specific+transplantation+tolerance+induction+by+vascular+allografts+across+a+class+I+difference+in+miniature+swine.&rft.au=Kortz%2C+E+O%3BSachs%2C+D+H&rft.aulast=Kortz&rft.aufirst=E&rft.date=1987-02-01&rft.volume=19&rft.issue=1+Pt+1&rft.spage=861&rft.isbn=&rft.btitle=&rft.title=Transplantation+proceedings&rft.issn=00411345&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-28 N1 - Date created - 1990-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Current and future uses of recombinant interferon alpha in the treatment of low-grade non-Hodgkin's lymphoma. AN - 77346546; 10822466 AB - Recombinant and natural forms of interferon alpha have been shown to bring about tumor regressions in patients with low-grade non-Hodgkin's lymphoma. Complete and partial response rates in up to 50% of patients have been documented. Although these studies are encouraging, interferon alpha's role in the current management of patients with low-grade non-Hodgkin's lymphoma is not apparent. The high doses of interferon that were used in some of the recent studies were not well tolerated by these patients. Current studies using interferon in patients with low-grade non-Hodgkin's lymphomas are evaluating lower, and perhaps better tolerated doses of interferon. In addition, in vitro studies have documented additive and sometimes synergistic antitumor effects of interferon in combination with cytotoxic drugs. This approach is being extended to the clinic, and trials are now underway evaluating combinations of interferon and various cytotoxic drugs known from previous studies to be active in patients with low-grade non-Hodgkin's lymphomas. This report reviews studies using interferon alone in these patients, and discusses ongoing and proposed studies for the future use of interferon in treating this disease. JF - Cancer AU - Steis, R G AU - Foon, K A AU - Longo, D L AD - Biological Response Modifiers Program, National Cancer Institute, Frederick, Maryland, USA. Y1 - 1987/02/01/ PY - 1987 DA - 1987 Feb 01 SP - 658 EP - 663 VL - 59 IS - 3 Suppl SN - 0008-543X, 0008-543X KW - Antineoplastic Agents KW - 0 KW - Interferon Type I KW - Interferon-alpha KW - Recombinant Proteins KW - Abridged Index Medicus KW - Index Medicus KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- administration & dosage KW - Humans KW - Clinical Trials as Topic KW - Drug Synergism KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Remission Induction KW - Lymphoma, Non-Hodgkin -- drug therapy KW - Interferon Type I -- administration & dosage KW - Antineoplastic Agents -- administration & dosage KW - Interferon Type I -- therapeutic use KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77346546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Current+and+future+uses+of+recombinant+interferon+alpha+in+the+treatment+of+low-grade+non-Hodgkin%27s+lymphoma.&rft.au=Steis%2C+R+G%3BFoon%2C+K+A%3BLongo%2C+D+L&rft.aulast=Steis&rft.aufirst=R&rft.date=1987-02-01&rft.volume=59&rft.issue=3+Suppl&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-14 N1 - Date created - 2000-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular dosimetry of O6-methylguanine formation and cell toxicity in lung and nasal mucosa by 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone. AN - 81121940; 3679414 AB - The molecular dosimetry of O6-methylguanine (O6-meG) in DNA from lung and nasal mucosa was determined during administration of 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) to Fischer 344 rats. O6-MeG accumulated in lung during 12 days of treatment with doses of NNK ranging from 0.1 to 100 mg/kg per day. The dose-response to NNK was nonlinear; the ratio of O6-meG to dose, an index of alkylation efficiency, increased dramatically as the dose of carcinogen decreased. These data suggest that high and low Km pathways may exist for activation of NNK to a methylating agent. Clara cells, when compared to Type-II cells, macrophages and alveolar small cells, were found to possess the greatest concentration of O6-meG. Moreover, as the dose of NNK was decreased, a marked increase in the alkylation efficiency of Clara cells was observed. Thus, the presence of a high-affinity, low-Km pathway in Clara cells for activation of NNK may be a significant factor in the carcinogenicity of this tobacco-specific carcinogen. The dose-response for O6-meG differed considerably between respiratory and olfactory mucosa. The dose-response to NNK was nonlinear in respiratory mucosa and linear in the olfactory mucosa, and the concentration of O6-meG was five times greater in respiratory than in olfactory mucosa after treatment with 1 mg/kg NNK. As the dose of NNK was increased, alkylation in the two regions of the nose became similar. Histological examination of the nasal passages following treatment with NNK indicated that the olfactory region was more sensitive than the respiratory region to toxicity induced by NNK.(ABSTRACT TRUNCATED AT 250 WORDS) JF - IARC scientific publications AU - Belinsky, S A AU - Swenberg, J A AU - Anderson, M W AD - Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987 PY - 1987 DA - 1987 SP - 430 EP - 433 IS - 84 SN - 0300-5038, 0300-5038 KW - Nitrosamines KW - 0 KW - Guanine KW - 5Z93L87A1R KW - 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone KW - 7S395EDO61 KW - O-(6)-methylguanine KW - 9B710FV2AE KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Nitrosamines -- toxicity KW - Nasal Mucosa -- pathology KW - Lung -- drug effects KW - Guanine -- analysis KW - Guanine -- analogs & derivatives KW - Nasal Mucosa -- drug effects KW - Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81121940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=Molecular+dosimetry+of+O6-methylguanine+formation+and+cell+toxicity+in+lung+and+nasal+mucosa+by+4-%28N-nitrosomethylamino%29-1-%283-pyridyl%29-1-butanone.&rft.au=Belinsky%2C+S+A%3BSwenberg%2C+J+A%3BAnderson%2C+M+W&rft.aulast=Belinsky&rft.aufirst=S&rft.date=1987-01-01&rft.volume=&rft.issue=84&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-12 N1 - Date created - 1988-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biochemical and molecular effects of N-nitroso compounds in human cultured cells: an overview. AN - 81120709; 3315996 AB - In-vitro models using human tissues and cells provide a bridge between studies of humans and of laboratory animals. Cultured human cells activate N-nitrosamines to DNA-damaging metabolites, including alkyldiazonium ions and aldehydes; these metabolites can also inactivate DNA repair processes, such as O6-alkylguanine DNA-alkyltransferase (AAT) activity, and are mutagenic in human cells. Both human epithelial and mesenchymal cells have been transformed in vitro by N-nitroso compounds. JF - IARC scientific publications AU - Harris, C C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 20 EP - 25 IS - 84 SN - 0300-5038, 0300-5038 KW - Nitroso Compounds KW - 0 KW - Smoke KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Humans KW - DNA -- metabolism KW - In Vitro Techniques KW - Chromosome Aberrations KW - Smoke -- analysis KW - Mutation KW - DNA Repair -- drug effects KW - Cell Transformation, Neoplastic KW - Nitroso Compounds -- metabolism KW - Nitroso Compounds -- toxicity KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81120709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=Biochemical+and+molecular+effects+of+N-nitroso+compounds+in+human+cultured+cells%3A+an+overview.&rft.au=Harris%2C+C+C&rft.aulast=Harris&rft.aufirst=C&rft.date=1987-01-01&rft.volume=&rft.issue=84&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-12 N1 - Date created - 1988-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Potential for metabolic deactivation of carcinogenic N-nitrosodimethylamine in vivo. AN - 81120195; 3679346 AB - Enzymatic cleavage of N-nitrosodimethylamine (NDMA) to nitrite (normally representing about 10% of the total metabolism in vitro) also produces methylamine in yields roughly equimolar to those of nitrite, suggesting that the 'denitrosation' pathway may be responsible for the previously unexplained detection of methylamine as a urinary metabolite of NDMA and, at least in part, for the recovery of less than stoichiometric amounts of dinitrogen in 15N-labelling experiments. We have now followed excretion of labelled methylamine by rats receiving 14C-NDMA as a possible index of the extent of in-vivo denitrosation. Correcting for the proportion of labelled methylamine recovered in the urine following its administration under the conditions used for NDMA, 2.5-10% of the NDMA metabolism in Fischer rats appeared to proceed by a methylamine-forming route. The results are consistent with the conclusion that the metabolism of NDMA is best viewed as a competition between two pathways, with denitrosation diverting a significant proportion of the clearance to a presumably deactivating metabolic route at the expense of the activating alkylation pathway responsible for carcinogenesis. JF - IARC scientific publications AU - Keefer, L K AU - Anjo, T AU - Heur, Y H AU - Yang, C S AU - Mico, B A AD - Chemistry Section, National Cancer Institute, Frederick Cancer Research Facility, MD 21701. Y1 - 1987 PY - 1987 DA - 1987 SP - 113 EP - 116 IS - 84 SN - 0300-5038, 0300-5038 KW - Methylamines KW - 0 KW - Nitrites KW - methylamine KW - BSF23SJ79E KW - Dimethylnitrosamine KW - M43H21IO8R KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Inactivation, Metabolic KW - Nitrites -- metabolism KW - Methylamines -- urine KW - Alkylation KW - Dimethylnitrosamine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81120195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=Potential+for+metabolic+deactivation+of+carcinogenic+N-nitrosodimethylamine+in+vivo.&rft.au=Keefer%2C+L+K%3BAnjo%2C+T%3BHeur%2C+Y+H%3BYang%2C+C+S%3BMico%2C+B+A&rft.aulast=Keefer&rft.aufirst=L&rft.date=1987-01-01&rft.volume=&rft.issue=84&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-12 N1 - Date created - 1988-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mechanism of cadmium-metallothionein-induced nephrotoxicity: relationship to altered renal calcium metabolism. AN - 81071598; 2822468 AB - Prolonged cadmium exposure has been associated with proteinuria, calcuria and loss of calcium from bones in humans. Previous studies have shown that kidney uptake of cadmium in vivo results from proximal tubule absorption of the circulating cadmium metallothionein complex (CdMT), and intracellular release of the Cd2+ ion prior to induction of renal metallothionein. Parenteral administration of CdMT has been found to selectively damage the proximal tubule cell lysosome system with development of a tubular proteinuria pattern similar to that observed under chronic exposure conditions. The present studies also demonstrate a concomitant calcuria but no changes in the excretion of other electrolytes or glucose using this model. These marked changes in renal calcium metabolism occurred in the absence of mitochondrial damage, changes in total, Na/K or Mg-stimulated ATPase activities, renal ATP levels, membrane 45Ca2+ transport or overt tubule cell necrosis during an 8 hour period following CdMT injection. Proteinuria and calcuria were prevented by prior zinc induction of the renal MT pool. Data from these studies indicate that renal proximal tubule cell uptake and degradation of the circulating CdMT complex produces both a marked proteinuria and calcuria. The calcuria does not appear to stem from changes in renal energy metabolism or membrane transport of this element but is probably a secondary result of calcium binding to excreted proteins which are increased in urine to a similar extent. The studies also suggest that zinc status and maintenance of the renal ZnMT pool may play an important role in regulating cadmium-induced renal proteinuria and calcuria by preventing Cd2+ perturbation of the proximal tubule cell lysosome system. JF - Experientia. Supplementum AU - Fowler, B A AU - Goering, P L AU - Squibb, K S AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987 PY - 1987 DA - 1987 SP - 661 EP - 668 VL - 52 SN - 0071-335X, 0071-335X KW - cadmium-binding protein KW - 0 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Metallothionein KW - 9038-94-2 KW - Ca(2+) Mg(2+)-ATPase KW - EC 3.6.1.- KW - Sodium-Potassium-Exchanging ATPase KW - EC 3.6.3.9 KW - Zinc KW - J41CSQ7QDS KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Biological Transport KW - Proteinuria -- metabolism KW - Lysosomes -- metabolism KW - Rats KW - Zinc -- pharmacology KW - Sodium-Potassium-Exchanging ATPase -- metabolism KW - Mitochondria -- ultrastructure KW - Kidney Tubules, Proximal -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Cell Membrane -- metabolism KW - Ca(2+) Mg(2+)-ATPase -- metabolism KW - Proteinuria -- chemically induced KW - Calcium -- metabolism KW - Kidney Diseases -- metabolism KW - Kidney -- metabolism KW - Metallothionein -- biosynthesis KW - Metallothionein -- pharmacokinetics KW - Kidney -- drug effects KW - Kidney -- ultrastructure KW - Calcium -- urine KW - Metallothionein -- toxicity KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81071598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experientia.+Supplementum&rft.atitle=Mechanism+of+cadmium-metallothionein-induced+nephrotoxicity%3A+relationship+to+altered+renal+calcium+metabolism.&rft.au=Fowler%2C+B+A%3BGoering%2C+P+L%3BSquibb%2C+K+S&rft.aulast=Fowler&rft.aufirst=B&rft.date=1987-01-01&rft.volume=52&rft.issue=&rft.spage=661&rft.isbn=&rft.btitle=&rft.title=Experientia.+Supplementum&rft.issn=0071335X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-15 N1 - Date created - 1987-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use of multistage models to infer stage affected by carcinogenic exposure: example of lung cancer and cigarette smoking. AN - 81069045; 3667864 AB - Statistical methods based on the Armitage-Doll mathematical model of the carcinogenic process are presented for analyzing epidemiologic case-control studies of cancer. These methods are proposed to provide inferences regarding the stage(s) in the cancer process at which the exposure of interest acts. An example of these methods is given which shows evidence that carcinogens in cigarette smoke appear to affect the transition rates for two separate stages in the development of lung cancer, and the relative magnitudes of these effects are estimated. The data for this analysis came from a European multi-center case-control study of lung cancer. The results of the analysis show that: (1) the relative risk of lung cancer among continuing smokers compared to nonsmokers of the same age decreases as the age started smoking increases, while the rate of smoking stays fixed, a result which indicates a carcinogenic effect on an early stage in the process; and (2) the relative risk among ex-smokers compared to continuing smokers having the same duration and rate of smoking decreases with time since smoking stopped, a result which indicates a carcinogenic effect on a late stage in the process. Both results are shown to be best described by the hypothesis that cigarette smoking affects two stages. The estimated relative magnitudes of cigarettes' carcinogenic effects on the two stages indicate that the largest proportion of the total lifetime lung cancer risk among continuing smokers is due to its late stage effect, and that the proportion of risk due to causes other than smoking varies from 23% among men smoking 1-10 cigarettes per day to 6% among those smoking greater than 30 cigarettes per day. These findings imply that preventive measures directed toward inducing smokers to stop would have a potentially substantial payoff in reducing future lung cancer mortality. JF - Journal of chronic diseases AU - Brown, C C AU - Chu, K C AD - Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20205. Y1 - 1987 PY - 1987 DA - 1987 SP - 171S EP - 179S VL - 40 Suppl 2 SN - 0021-9681, 0021-9681 KW - Index Medicus KW - Regression Analysis KW - Age Factors KW - Epidemiologic Methods KW - Humans KW - Statistics as Topic KW - Time Factors KW - Lung Neoplasms -- etiology KW - Smoking -- adverse effects KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81069045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chronic+diseases&rft.atitle=Use+of+multistage+models+to+infer+stage+affected+by+carcinogenic+exposure%3A+example+of+lung+cancer+and+cigarette+smoking.&rft.au=Brown%2C+C+C%3BChu%2C+K+C&rft.aulast=Brown&rft.aufirst=C&rft.date=1987-01-01&rft.volume=40+Suppl+2&rft.issue=&rft.spage=171S&rft.isbn=&rft.btitle=&rft.title=Journal+of+chronic+diseases&rft.issn=00219681&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-15 N1 - Date created - 1987-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Temporal distributions of risk for radiation-induced cancers. AN - 81066188; 3312274 AB - Observations of cancer risk in irradiated human populations over time after exposure suggest that there are at least two, and perhaps more, very different patterns of temporal distribution of risk for radiation-induced cancer. The first, exemplified by bone sarcoma following therapeutic injection of 224Ra and chronic granulocytic leukemia in Japanese A-bomb survivors, is an early, wave-like pulse consisting of an increase in risk followed by a gradual decline back to baseline levels. The second, exemplified by breast cancer following a brief exposure to external gamma ray or X ray, and by lung cancer and stomach cancer in A-bomb survivors, is an increase in relative risk over about 10 years to a value which appears to remain constant over time thereafter. The first pattern suggests that tumor growth kinetics may play a central role in the temporal distribution of risk following exposure, while the second seems more consistent with multi-event models for carcinogenesis, in which radiation or some other cause of early events must be followed by one or more later events whose frequencies depend mainly on attained age. There are, however, other data that appear to conform to neither of the two models just mentioned. Influences of other cancer causes, like tobacco smoking, are potentially serious confounding factors in studies of induction period. JF - Journal of chronic diseases AU - Land, C E AD - Radiation Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 45S EP - 57S VL - 40 Suppl 2 SN - 0021-9681, 0021-9681 KW - Index Medicus KW - Risk Factors KW - Nuclear Warfare KW - Humans KW - Leukemia, Radiation-Induced -- etiology KW - Adult KW - Breast Neoplasms -- etiology KW - Child KW - Time Factors KW - Models, Biological KW - Female KW - Neoplasms, Radiation-Induced -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81066188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chronic+diseases&rft.atitle=Temporal+distributions+of+risk+for+radiation-induced+cancers.&rft.au=Land%2C+C+E&rft.aulast=Land&rft.aufirst=C&rft.date=1987-01-01&rft.volume=40+Suppl+2&rft.issue=&rft.spage=45S&rft.isbn=&rft.btitle=&rft.title=Journal+of+chronic+diseases&rft.issn=00219681&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-15 N1 - Date created - 1987-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A nonmathematical view of mathematical models for cancer. AN - 81065989; 3667862 AB - A qualitative view of mathematical models for cancer is presented. The Armitage and Doll multistage and Moolgavkar two-stage models of cancer are discussed in terms of their physical models. Time-related factors for these models as well as some of their characteristics are presented. The effect of age at first exposure, duration of exposure, time since last exposure and stage of carcinogenic effect on risk are detailed. JF - Journal of chronic diseases AU - Chu, K C AD - Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 163S EP - 170S VL - 40 Suppl 2 SN - 0021-9681, 0021-9681 KW - Index Medicus KW - Age Factors KW - Risk Factors KW - Humans KW - Time Factors KW - Cell Transformation, Neoplastic KW - Mathematics KW - Neoplasms -- physiopathology KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81065989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chronic+diseases&rft.atitle=A+nonmathematical+view+of+mathematical+models+for+cancer.&rft.au=Chu%2C+K+C&rft.aulast=Chu&rft.aufirst=K&rft.date=1987-01-01&rft.volume=40+Suppl+2&rft.issue=&rft.spage=163S&rft.isbn=&rft.btitle=&rft.title=Journal+of+chronic+diseases&rft.issn=00219681&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-15 N1 - Date created - 1987-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Abnormal copper metabolism and regulation of metallothionein gene expression in Menkes' disease. AN - 81064255; 2959538 AB - Menkes' kinky hair disease, a lethal X-linked recessive trait, is characterized by abnormal copper accumulation in several non-hepatic tissues. The level of many copper enzymes is severely reduced, leading to damage of the connective and nervous tissues of the patients. Cultured skin fibroblasts from Menkes' patients retain more copper then normal controls, and the excess metal is bound to metallothionein. Low doses of copper in the media induce MT gene transcription in Menkes' but not in normal cells. Transfection experiments using a plasmid containing the mouse MT-I promoter fused to the enzyme chloramphenicol acetyl transferase show that the activation of the mMTI promoter is in trans. Two other effects are observed in Menkes' cells: (a) two heat-shock like proteins are synthesized in response to low doses of copper in the growth medium, and (b) Menkes' cells are more sensitive then normal fibroblasts to copper toxicity. Our interpretation of these results supports a model for a defect in one or more steps in copper metabolism or transport. JF - Experientia. Supplementum AU - Leone, A AU - Hamer, D H AD - Laboratory of Biochemistry, National Cancer Institute, Bethesda, MD 20205. Y1 - 1987 PY - 1987 DA - 1987 SP - 477 EP - 480 VL - 52 SN - 0071-335X, 0071-335X KW - DNA, Recombinant KW - 0 KW - RNA, Messenger KW - Copper KW - 789U1901C5 KW - Metallothionein KW - 9038-94-2 KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Protein Biosynthesis -- drug effects KW - Zinc -- pharmacology KW - Promoter Regions, Genetic KW - Transcription, Genetic -- drug effects KW - Transfection KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Humans KW - RNA, Messenger -- genetics KW - Fibroblasts -- metabolism KW - Menkes Kinky Hair Syndrome -- genetics KW - Brain Diseases, Metabolic -- genetics KW - Menkes Kinky Hair Syndrome -- metabolism KW - Copper -- metabolism KW - Metallothionein -- genetics KW - Gene Expression Regulation -- drug effects KW - Copper -- pharmacology KW - Metallothionein -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81064255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experientia.+Supplementum&rft.atitle=Abnormal+copper+metabolism+and+regulation+of+metallothionein+gene+expression+in+Menkes%27+disease.&rft.au=Leone%2C+A%3BHamer%2C+D+H&rft.aulast=Leone&rft.aufirst=A&rft.date=1987-01-01&rft.volume=52&rft.issue=&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Experientia.+Supplementum&rft.issn=0071335X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-15 N1 - Date created - 1987-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 5-Methyltetrahydrohomofolate. AN - 81062464; 3312079 AB - 5-methyltetrahydrohomofolate was developed in the 1970's as an antifolate with the potential to overcome methotrexate resistance. This review summarizes the preclinical and clinical data which have accumulated to date. It is concluded that more recent, better characterized antifolates offer greater potential in achieving the goals for which this drug was introduced. JF - Investigational new drugs AU - O'Dwyer, P J AU - Wagner, B H AU - Hoth, D F AU - Leyland-Jones, B AD - Investigational Drug Branch, National Cancer Institute, Philadelphia. Y1 - 1987 PY - 1987 DA - 1987 SP - 215 EP - 218 VL - 5 IS - 3 SN - 0167-6997, 0167-6997 KW - Antimetabolites, Antineoplastic KW - 0 KW - Folic Acid Antagonists KW - 5-methyltetrahydrohomofolic acid KW - 52196-22-2 KW - Folic Acid KW - 935E97BOY8 KW - Index Medicus KW - Drug Evaluation KW - Animals KW - Humans KW - Folic Acid Antagonists -- therapeutic use KW - Folic Acid Antagonists -- pharmacology KW - Folic Acid -- pharmacokinetics KW - Folic Acid -- analogs & derivatives KW - Folic Acid -- therapeutic use KW - Folic Acid Antagonists -- pharmacokinetics KW - Antimetabolites, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81062464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+new+drugs&rft.atitle=5-Methyltetrahydrohomofolate.&rft.au=O%27Dwyer%2C+P+J%3BWagner%2C+B+H%3BHoth%2C+D+F%3BLeyland-Jones%2C+B&rft.aulast=O%27Dwyer&rft.aufirst=P&rft.date=1987-01-01&rft.volume=5&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Investigational+new+drugs&rft.issn=01676997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-17 N1 - Date created - 1987-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Radiolabeled monoclonal antibody B72.3 localization in metastatic lesions of colorectal cancer patients. AN - 81060504; 3667307 AB - We have previously demonstrated a high degree of selective binding of monoclonal antibody (MAb) B72.3 to carcinomas of the colon, ovary, and breast in contrast to normal adult tissues using in vitro assays. In this report we demonstrate selective tumor localization in colorectal cancer patients after intravenously administering 131I-labeled MAb B72.3 IgG. Radiolocalization Indices (RI) (i.e. cpm 131I-labeled MAb per gram of tumor vs cpm per gram of normal tissues), were obtained by direct analyses of biopsy materials. Using an RI of greater than or equal to 3 as a positive localization, tumor lesions in various sites from 17/20 patients scored positive. In eight of these patients, all tumor lesions demonstrated RIs of greater than 3, while in five patients RIs of some lesions were greater than 10 and as high as 30-46. Seventy percent (99/142) of the tumor lesions showed RIs of greater than 3, while only 12 of 210 histologically confirmed normal tissues examined showed RIs of greater than 3. These tissues were either adjacent to the tumor or the draining tumor masses or, as in the case of two patients, was caused by high levels of circulating immune complexes that deposited in the spleen. Positive scintigraphic images (confirmed at surgery) were observed in 14/27 patients. No toxicity or adverse reactions were observed with either MAb. These studies provide absolute quantitative analyses of the actual delivery of radiolabeled MAb to carcinoma lesions vs a wide range of adjacent and distal normal tissues and establishes the means for other diagnostic and potential therapeutic applications of this antibody alone, or in combinations with other monoclonal antibodies. JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology AU - Colcher, D AU - Carrasquillo, J A AU - Esteban, J M AU - Sugarbaker, P AU - Reynolds, J C AU - Siler, K AU - Bryant, G AU - Larson, S M AU - Schlom, J AD - Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 251 EP - 262 VL - 14 IS - 3 SN - 0883-2897, 0883-2897 KW - Antibodies, Monoclonal KW - 0 KW - Iodine Radioisotopes KW - Index Medicus KW - Humans KW - Radionuclide Imaging KW - Rectal Neoplasms -- metabolism KW - Neoplasm Metastasis -- diagnostic imaging KW - Rectal Neoplasms -- diagnostic imaging KW - Antibodies, Monoclonal -- metabolism KW - Neoplasm Metastasis -- metabolism KW - Colonic Neoplasms -- metabolism KW - Colonic Neoplasms -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81060504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+applications+and+instrumentation.+Part+B%2C+Nuclear+medicine+and+biology&rft.atitle=Radiolabeled+monoclonal+antibody+B72.3+localization+in+metastatic+lesions+of+colorectal+cancer+patients.&rft.au=Colcher%2C+D%3BCarrasquillo%2C+J+A%3BEsteban%2C+J+M%3BSugarbaker%2C+P%3BReynolds%2C+J+C%3BSiler%2C+K%3BBryant%2C+G%3BLarson%2C+S+M%3BSchlom%2C+J&rft.aulast=Colcher&rft.aufirst=D&rft.date=1987-01-01&rft.volume=14&rft.issue=3&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+applications+and+instrumentation.+Part+B%2C+Nuclear+medicine+and+biology&rft.issn=08832897&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-01 N1 - Date created - 1987-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The association of solar ultraviolet and skin melanoma incidence among caucasians in the United States. AN - 81056638; 3664331 AB - Using recent data from cancer incidence surveys and measures of UVB exposure levels at seven geographic locations within the United States, we estimate the dose-response relation between UVB and skin melanoma incidence. Mathematical models used information from general population interview studies conducted in these locations to adjust for potentially confounding factors such as age, skin color, ancestry, eye color, hair color, sunburn sensitivity, prevalence of moles, freckles, and hours spent outdoors, use of sunscreen/lotion, and other variables. The effect of geographic UVB exposure on incidence was found to be statistically significant (p less than 0.01) after adjusting for each variable and certain combinations of these variables. We found that incidence rates for those skin melanomas arising in the face, head, neck, or upper extremities (i.e, the most exposed sites) were more sensitive to UVB increases than the incidence rates for those lesions occurring in the ordinarily less exposed sites of the trunk and lower extremities. JF - Cancer investigation AU - Scotto, J AU - Fears, T R AD - Biostatistics Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 275 EP - 283 VL - 5 IS - 4 SN - 0735-7907, 0735-7907 KW - Index Medicus KW - United States KW - Sex Factors KW - Humans KW - Male KW - Female KW - Neoplasms, Radiation-Induced -- etiology KW - Skin Neoplasms -- etiology KW - Neoplasms, Radiation-Induced -- epidemiology KW - Melanoma -- etiology KW - European Continental Ancestry Group KW - Ultraviolet Rays -- adverse effects KW - Skin Neoplasms -- epidemiology KW - Melanoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81056638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+investigation&rft.atitle=The+association+of+solar+ultraviolet+and+skin+melanoma+incidence+among+caucasians+in+the+United+States.&rft.au=Scotto%2C+J%3BFears%2C+T+R&rft.aulast=Scotto&rft.aufirst=J&rft.date=1987-01-01&rft.volume=5&rft.issue=4&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Cancer+investigation&rft.issn=07357907&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-11 N1 - Date created - 1987-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - AIDS, HTLV-III diseases, minorities and intravenous drug abuse. AN - 81055308; 3661301 AB - Minorities and women who are engaging in activities which place them at high risk for infection with HTLV-III are developing HTLV-III related illnesses including AIDS. In Northeastern urban areas the relatively large number of minorities who use intravenous drugs are responsible for producing large numbers of patients with AIDS (PWAs). Eighty percent of heterosexual male and female PWAs are Black or Hispanic. The development and implementation of effective prevention and education programs for these individuals rests upon an understanding of the less traditional approaches which may be necessary to reach these groups. The general public must be made aware of the hazards of HTLV-III related diseases and that the risk of infection is restricted to very well defined high risk groups. Minorities must be made to understand that they are at increased risk for HTLV-III related diseases only because of the high incidence of drug abuse in their community. JF - Advances in alcohol & substance abuse AU - Ginzburg, H M AU - MacDonald, M G AU - Glass, J W AD - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 7 EP - 21 VL - 6 IS - 3 SN - 0270-3106, 0270-3106 KW - Index Medicus KW - AIDS/HIV KW - United States KW - Minority Groups KW - Risk Factors KW - Humans KW - Adult KW - Health Education -- methods KW - Male KW - Female KW - Acquired Immunodeficiency Syndrome -- prevention & control KW - Acquired Immunodeficiency Syndrome -- epidemiology KW - Ethnic Groups KW - Injections, Intravenous -- adverse effects KW - Substance-Related Disorders -- complications KW - Acquired Immunodeficiency Syndrome -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81055308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+alcohol+%26+substance+abuse&rft.atitle=AIDS%2C+HTLV-III+diseases%2C+minorities+and+intravenous+drug+abuse.&rft.au=Ginzburg%2C+H+M%3BMacDonald%2C+M+G%3BGlass%2C+J+W&rft.aulast=Ginzburg&rft.aufirst=H&rft.date=1987-01-01&rft.volume=6&rft.issue=3&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Advances+in+alcohol+%26+substance+abuse&rft.issn=02703106&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-13 N1 - Date created - 1987-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Adoptive chemoimmunotherapy of murine leukemia: dissemination, survival, and function of helper T lymphocyte clones. AN - 81042218; 2958876 JF - Progress in clinical and biological research AU - Bookman, M A AU - Groves, E S AU - Matis, L A AD - Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 93 EP - 103 VL - 244 SN - 0361-7742, 0361-7742 KW - Antigens, Differentiation, T-Lymphocyte KW - 0 KW - Antigens, Neoplasm KW - Retroviridae Proteins KW - Retroviridae Proteins, Oncogenic KW - Viral Envelope Proteins KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Animals KW - Combined Modality Therapy KW - Mice KW - Cell Survival KW - Lymphocyte Activation KW - Viral Envelope Proteins -- immunology KW - Antigens, Differentiation, T-Lymphocyte -- analysis KW - Hypersensitivity, Delayed KW - Immunity, Cellular KW - Retroviridae Proteins -- immunology KW - Antigen-Presenting Cells -- immunology KW - Antigens, Neoplasm -- immunology KW - Clone Cells -- immunology KW - T-Lymphocytes, Helper-Inducer -- classification KW - Leukemia, Experimental -- drug therapy KW - Immunization, Passive KW - T-Lymphocytes, Helper-Inducer -- immunology KW - Leukemia, Experimental -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81042218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Adoptive+chemoimmunotherapy+of+murine+leukemia%3A+dissemination%2C+survival%2C+and+function+of+helper+T+lymphocyte+clones.&rft.au=Bookman%2C+M+A%3BGroves%2C+E+S%3BMatis%2C+L+A&rft.aulast=Bookman&rft.aufirst=M&rft.date=1987-01-01&rft.volume=244&rft.issue=&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-19 N1 - Date created - 1987-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Replicative cultures of human prostatic epithelial cells. AN - 81039119; 3309962 JF - Progress in clinical and biological research AU - Lechner, J F AD - In Vitro Carcinogenesis Section, NCI, Bethesda, MD 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 497 EP - 509 VL - 239 SN - 0361-7742, 0361-7742 KW - Index Medicus KW - Prostatic Neoplasms -- etiology KW - Cytological Techniques KW - Epithelial Cells KW - Cells, Cultured KW - Humans KW - Cell Differentiation KW - Male KW - Prostate -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81039119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Replicative+cultures+of+human+prostatic+epithelial+cells.&rft.au=Lechner%2C+J+F&rft.aulast=Lechner&rft.aufirst=J&rft.date=1987-01-01&rft.volume=239&rft.issue=&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-03 N1 - Date created - 1987-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Merbarone: an antitumor agent entering clinical trials. AN - 81021660; 3308762 AB - Merbarone was developed to clinical trial stage on the basis of its 'curative' activity against P388 and L1210 leukemias and moderate activity against B16 melanoma and M5076 sarcoma. Its activity appears to be schedule-dependent favoring a longer duration of administration. The mechanism of action of merbarone is not yet established but it does induce single strand breaks in DNA apparently without binding to DNA. The pharmacokinetic data in the dog indicate that clearance mechanisms may be saturable. Merbarone is hydroxylated at the 4' position in the rat, mouse and dog, and glucuronidated in the dog. Parent drug and the hydroxy metabolite are excreted in the urine. If saturable clearance mechanisms also pertain to man, this will mean that infusion rate (and therefore steady state concentrations reached) may be a significant factor in determining acute toxicity. Preclinical toxicology studies revealed that major target tissues are in the lymphoid organs, bone marrow, gastrointestinal tract and kidney. Some behavioral signs of reversible central nervous system toxicity were observed. Phase I trials have commenced using only a 5-day continuous intravenous infusion schedule based on the preclinical data. The pharmacokinetic information from these trials will be crucial for further clinical development of the compound, including selection of the optimal schedule(s) for phase II/III evaluation. JF - Investigational new drugs AU - Glover, A AU - Chun, H G AU - Kleinman, L M AU - Cooney, D A AU - Plowman, J AU - Grieshaber, C K AU - Malspeis, L AU - Leyland-Jones, B AD - Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD. Y1 - 1987 PY - 1987 DA - 1987 SP - 137 EP - 143 VL - 5 IS - 2 SN - 0167-6997, 0167-6997 KW - Antineoplastic Agents KW - 0 KW - Thiobarbiturates KW - merbarone KW - 97534-21-9 KW - Index Medicus KW - Drug Evaluation KW - Animals KW - Humans KW - Thiobarbiturates -- toxicity KW - Antineoplastic Agents -- pharmacokinetics KW - Thiobarbiturates -- pharmacokinetics KW - Antineoplastic Agents -- toxicity KW - Antineoplastic Agents -- therapeutic use KW - Thiobarbiturates -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81021660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+new+drugs&rft.atitle=Merbarone%3A+an+antitumor+agent+entering+clinical+trials.&rft.au=Glover%2C+A%3BChun%2C+H+G%3BKleinman%2C+L+M%3BCooney%2C+D+A%3BPlowman%2C+J%3BGrieshaber%2C+C+K%3BMalspeis%2C+L%3BLeyland-Jones%2C+B&rft.aulast=Glover&rft.aufirst=A&rft.date=1987-01-01&rft.volume=5&rft.issue=2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Investigational+new+drugs&rft.issn=01676997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-02 N1 - Date created - 1987-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preclinical approaches to the treatment of metastatic disease: therapeutic properties of rH TNF, rM IFN-gamma, and rH IL-2. AN - 81017680; 3115744 AB - The present studies were undertaken to examine the immunotherapeutic properties of recombinant murine interferon-gamma (rM IFN-gamma), recombinant human tumour necrosis factor (rH TNF), and recombinant human interleukin-2 (rH IL-2) in preclinical metastasis models. It was observed that these cytokines have disparate mechanisms of therapeutic activity as well as different optimal therapeutic protocols. Thus, not only is the dose important to the therapeutic activity of each of the agents; so also is the route of administration, schedule of administration, duration of administration, and sequence of administration. The rM IFN-gamma has a narrow window of activity, with a bell-shaped therapeutic response with a dosage optimum at 50,000 U/animal of rM IFN-gamma administered 3 times per week. In contrast, rH IL-2 has optimal therapeutic activity for the treatment of metastatic disease after i.p. as compared to i.v. administration. This appears to be associated with the serum pharmacokinetics, since longer serum concentrations are achieved following i.p. administration although lower serum levels are also achieved. RH IL-2 has a biphasic dose-response curve for therapeutic activity with optima from 100 to 1000 U/animal and at doses greater than 100,000 U/animal. The lower doses appear to be associated with T cell augmentation whereas the higher doses are associated with NK cell or LAK cell augmentation. RH TNF has therapeutic activity for the treatment of metastatic disease after i.v. but not i.p. administration. High levels of rH TNF are readily detected in the serum following i.v. administration, with a serum half-life of approximately 30 min. In contrast, only minimal serum TNF activity is observed after i.p. administration, suggesting that this may be the origin of the increased therapeutic activity following i.v. administration. Furthermore, rH TNF has additive therapeutic activity when administered in conjunction with suboptimal doses of rM IFN-gamma. Unfortunately, the additive therapeutic activity of rM IFN-gamma and rH TNF is also associated with increased toxicity. However, in preliminary experiments it was found that the b.i.d. administration of aspirin at 25 mg/kg resulted in decreased toxicity. In summary, the recombinant cytokines provide a challenge both preclinically and clinically to the development of optimal therapeutic protocols, and suggest that close attention must be paid to the dose, route, schedule, duration, and sequence of their administration. JF - Drugs under experimental and clinical research AU - Talmadge, J E AU - Black, P L AU - Tribble, H AU - Pennington, R AU - Bowersox, O AU - Schneider, M AU - Phillips, H AD - Preclinical Screening Laboratory, National Cancer Institute-Frederick Cancer Research Facility, Maryland 21701. Y1 - 1987 PY - 1987 DA - 1987 SP - 327 EP - 337 VL - 13 IS - 6 SN - 0378-6501, 0378-6501 KW - Interleukin-2 KW - 0 KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - Animals KW - Ultraviolet Rays KW - Melanoma -- drug therapy KW - Mice, Inbred C57BL KW - Neoplasms, Radiation-Induced -- drug therapy KW - Mice KW - Recombinant Proteins -- therapeutic use KW - Male KW - Interferon-gamma -- therapeutic use KW - Interleukin-2 -- therapeutic use KW - Neoplasm Metastasis KW - Neoplasms, Experimental -- drug therapy KW - Tumor Necrosis Factor-alpha -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81017680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drugs+under+experimental+and+clinical+research&rft.atitle=Preclinical+approaches+to+the+treatment+of+metastatic+disease%3A+therapeutic+properties+of+rH+TNF%2C+rM+IFN-gamma%2C+and+rH+IL-2.&rft.au=Talmadge%2C+J+E%3BBlack%2C+P+L%3BTribble%2C+H%3BPennington%2C+R%3BBowersox%2C+O%3BSchneider%2C+M%3BPhillips%2C+H&rft.aulast=Talmadge&rft.aufirst=J&rft.date=1987-01-01&rft.volume=13&rft.issue=6&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Drugs+under+experimental+and+clinical+research&rft.issn=03786501&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-20 N1 - Date created - 1987-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regulation of keratin gene expression during differentiation of epidermal and vaginal epithelial cells. AN - 81016651; 2443311 JF - Current topics in developmental biology AU - Roop, D R AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 195 EP - 207 VL - 22 SN - 0070-2153, 0070-2153 KW - Macromolecular Substances KW - 0 KW - RNA, Messenger KW - RNA KW - 63231-63-0 KW - Keratins KW - 68238-35-7 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Epithelial Cells KW - DNA -- genetics KW - RNA, Messenger -- analysis KW - Cell Differentiation KW - RNA -- analysis KW - Nucleic Acid Hybridization KW - Female KW - Immunoassay KW - Keratins -- genetics KW - Vagina -- cytology KW - Epidermis -- cytology KW - Gene Expression Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81016651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+topics+in+developmental+biology&rft.atitle=Regulation+of+keratin+gene+expression+during+differentiation+of+epidermal+and+vaginal+epithelial+cells.&rft.au=Roop%2C+D+R&rft.aulast=Roop&rft.aufirst=D&rft.date=1987-01-01&rft.volume=22&rft.issue=&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Current+topics+in+developmental+biology&rft.issn=00702153&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-17 N1 - Date created - 1987-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transforming growth factor-beta: potential common mechanisms mediating its effects on embryogenesis, inflammation-repair, and carcinogenesis. AN - 81016456; 3308784 AB - In conclusion, we have demonstrated that a single growth factor, TGF-beta, can act in either an autocrine or paracrine mode to bring about, either directly or indirectly, all of the complex events which together lead to the formation of granulation tissue and tumor stroma. All of the participating cell types, lymphocytes, macrophages, endothelial cells, and fibroblasts have receptors for TGF-beta and many of them secrete TGF-beta as well. Although other growth factors such as platelet-derived growth factor and fibroblast growth factor clearly also participate in these processes, we have shown that TGF-beta, alone, is sufficient to initiate the cascade of events, probably through its ability to chemoattract and to activate macrophages and fibroblasts. Without question, neovascularization and appropriately timed matrix synthesis and degradation are central to embryogenesis as well. Fibronectin, in particular, has been shown to promote cell adhesion and cell migration throughout embryogenesis (Hynes and Yamada, 1982; Rovasio et al., 1983). We propose that TGF-beta will be found to be an important mediator of embryonic development, not only by control of angiogenesis and matrix synthesis, but also by exerting direct local effects on cellular growth and differentiation (reviewed in Roberts and Sporn, 1987). JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology AU - Roberts, A B AU - Sporn, M B AD - Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 435 EP - 439 VL - 14 IS - 4 SN - 0883-2897, 0883-2897 KW - Peptides KW - 0 KW - Transforming Growth Factors KW - 76057-06-2 KW - Index Medicus KW - Animals KW - Cattle KW - Humans KW - Inflammation -- physiopathology KW - Wound Healing KW - Cell Differentiation KW - Peptides -- physiology KW - Peptides -- isolation & purification KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81016456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+applications+and+instrumentation.+Part+B%2C+Nuclear+medicine+and+biology&rft.atitle=Transforming+growth+factor-beta%3A+potential+common+mechanisms+mediating+its+effects+on+embryogenesis%2C+inflammation-repair%2C+and+carcinogenesis.&rft.au=Roberts%2C+A+B%3BSporn%2C+M+B&rft.aulast=Roberts&rft.aufirst=A&rft.date=1987-01-01&rft.volume=14&rft.issue=4&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+applications+and+instrumentation.+Part+B%2C+Nuclear+medicine+and+biology&rft.issn=08832897&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-19 N1 - Date created - 1987-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Carcinoma of the urinary bladder associated with schistosomiasis in Egypt: the possible causal relationship. AN - 78072934; 3147281 AB - Carcinoma of the urinary bladder is the most common malignancy in Egyptians. At the National Cancer Institute in Cairo, it accounts for 27.6% of all cancers--38.5% of cancers in the male and 11.3% in the female. This very high frequency is attributed to underlying schistosomiasis. The infection can lead to malignancy through local tissue damage, mechanical irritation, bilharzial toxins or through secondary bacterial infection. Bacterial products include nitrate reductase capable of synthesizing nitrosoamines and beta glucuronidase enzymes, active at pH 7. Through liver involvement and dysfunction, tryptophan metabolism is disturbed, with the excretion of carcinogenic metabolites. Vitamin A deficiency is responsible for the squamous metaplasia and the high frequency of squamous cell carcinoma observed in the bladder. The characteristic clinico-pathological features of cancer of the urinary bladder are outlined, mainly the occurrence at a young age, the male predominance, especially farmers, and the high association with schistosomiasis. The tumors are often first seen in an advanced stage, arising from the posterior bladder wall and vault. The trigone is only affected in 8.5% of the cases. Histologically, squamous cell carcinomas of low grade are the most frequent cell type. Lymph node involvement is low in spite of the advanced stage of the tumor. Therefore, the results of radical surgery are encouraging. The results of a special study correlating the above parameters with the intensity of ova deposition are presented. Patients with heavy infection at a slightly earlier age but other tumor parameters the same are similar to those of egg-negative cases. This study indicates that other factors also play a role in the induction of tumors that are enhanced by the schistosomal infection. In Fayoum Province, schistosomiasis is decreasing while bladder cancer is increasing. Urine cytology as a screening tool is effective in detecting early bladder cancer. Studies are now in progress to detect tumor associated antigens in sera and urine of patients. JF - Princess Takamatsu symposia AU - Tawfik, H N AD - Department of Pathology, National Cancer Institute, Cairo University, Egypt. Y1 - 1987 PY - 1987 DA - 1987 SP - 197 EP - 209 VL - 18 KW - Index Medicus KW - Egypt KW - Carcinoma, Squamous Cell -- etiology KW - Carcinoma, Squamous Cell -- pathology KW - Humans KW - Adult KW - Middle Aged KW - Carcinoma, Papillary -- pathology KW - Carcinoma, Papillary -- etiology KW - Urinary Bladder Neoplasms -- pathology KW - Urinary Bladder Neoplasms -- etiology KW - Schistosomiasis haematobia -- complications KW - Urinary Bladder Neoplasms -- epidemiology KW - Schistosomiasis haematobia -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78072934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Princess+Takamatsu+symposia&rft.atitle=Carcinoma+of+the+urinary+bladder+associated+with+schistosomiasis+in+Egypt%3A+the+possible+causal+relationship.&rft.au=Tawfik%2C+H+N&rft.aulast=Tawfik&rft.aufirst=H&rft.date=1987-01-01&rft.volume=18&rft.issue=&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Princess+Takamatsu+symposia&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-27 N1 - Date created - 1989-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Nakahara memorial lecture. Rare events and cancer epidemiology. AN - 78055710; 3333498 AB - Physicians who think epidemiologically are rare. A method is suggested for detecting their aptitude early in their career when help may be offered to make the most of their special talent. Clusters geographically or in families may provide clues to cancer etiology. Clusters have been systematically thought by mapping cancer mortality in the US and independently in China. Case-control studies have revealed environmental exposure responsible for some of the clusters. Clusters noted by alert clinicians or other astute observers have revealed most of the known environmental causes of human cancers. Genetic influence in carcinogenesis has been identified by studies of peculiar cancer occurrence, such as familial aggregation, multiple primary cancer or the occurrence of cancer with other diseases as, for example, congenital malformations and immunodeficiency disorders. Ethnic differences in cancer occurrence may be revealing. Thus, in Japan there is low frequency of B-cell lymphoma but high frequency of certain autoimmune diseases, as if inherent protection against one predisposes the other. As a rule of thumb, the occurrence of three rare observations is not likely to be due to chance. Examples include ideal carcinoma in three persons with cystic fibrosis of the pancreas who survived to about 30 years of age, and the occurrence in Klinefelter's syndrome of germ cell tumor of the pineal--a neoplasm that has an unusually high frequency in Japan. Finally, the history of discoveries concerning cancer etiology, an aspect of what Comroe has called "research on research", can point the way to new discoveries in the future. JF - Princess Takamatsu symposia AU - Miller, R W AD - Clinical Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 3 EP - 12 VL - 18 KW - Index Medicus KW - Demography KW - Humans KW - Japan KW - Neoplasms -- epidemiology KW - Neoplasms -- genetics KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78055710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Princess+Takamatsu+symposia&rft.atitle=Nakahara+memorial+lecture.+Rare+events+and+cancer+epidemiology.&rft.au=Miller%2C+R+W&rft.aulast=Miller&rft.aufirst=R&rft.date=1987-01-01&rft.volume=18&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Princess+Takamatsu+symposia&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-27 N1 - Date created - 1989-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cholinergic transmission at newly formed synapses made by retinal neurons in culture. AN - 78054463; 2850621 AB - The purpose of this study was to investigate the properties of cholinergic transmission at nascent synapses formed by neurons from the embryonic chick retina. By using a cell culture system in which striated muscle cells served as postsynaptic targets for dissociated retinal neurons, it was possible to record synaptic activity soon after the establishment of a functional cholinergic synapse. Postsynaptic potentials ranged from a few hundred microvolts to greater than 10 mV. The high temperature dependence (Q10 of 10) of this cholinergic transmission indicated that the release of acetylcholine from the embryonic retinal neurons was not injury-related. The wide range in event amplitudes did not appear to be due to electrotonic conduction from adjacent myotubes. Rather, a lack of correlation between event amplitude and rise time indicated that the release of acetylcholine occurred over a confined area of contact. Amplitude histograms of these events always showed a unimodal distribution, with small events being most common. No pattern to the timing of the events was evident. In addition, the inward current blockers, tetrodotoxin and cadmium did not affect this activity. Taken together, our findings indicate that the embryonic retinal neurons studied in this culture system spontaneously release acetylcholine in a pulsatile manner by a mechanism that is stimulus-independent and highly temperature sensitive.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Synapse (New York, N.Y.) AU - Stockbridge, N AU - Puro, D G AD - Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland. Y1 - 1987 PY - 1987 DA - 1987 SP - 214 EP - 220 VL - 1 IS - 2 SN - 0887-4476, 0887-4476 KW - Tetrodotoxin KW - 4368-28-9 KW - Acetylcholine KW - N9YNS0M02X KW - Index Medicus KW - Rats KW - Animals KW - Cells, Cultured KW - Tetrodotoxin -- pharmacology KW - Acetylcholine -- physiology KW - Muscles -- cytology KW - Synapses -- physiology KW - Retinal Ganglion Cells -- physiology KW - Retina -- physiology KW - Synaptic Transmission -- drug effects KW - Muscles -- innervation KW - Retinal Ganglion Cells -- cytology KW - Muscles -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78054463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Cholinergic+transmission+at+newly+formed+synapses+made+by+retinal+neurons+in+culture.&rft.au=Stockbridge%2C+N%3BPuro%2C+D+G&rft.aulast=Stockbridge&rft.aufirst=N&rft.date=1987-01-01&rft.volume=1&rft.issue=2&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-21 N1 - Date created - 1989-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Diet and faecal genotoxicity. AN - 78019031; 3330684 AB - There are many known DNA-damaging substances in the diet, but their relevance to the aetiology of colorectal cancer is not clear. The examination of faecal contents provides the best available non-invasive way of studying 'exposures' of the colorectal mucosa including those that are of dietary origin. In particular, faecal genotoxicity is studied as a potential intermediate In particular, faecal genotoxicity is studied as a potential intermediate between dietary genotoxins and colorectal cancer. About 100 investigations of the DNA-modifying effects of faeces have been published in the 10 years since Bruce et al first observed faecal mutagenicity in extracts of stool from four human volunteers. In this review, the studies relating to diet and faecal genotoxicity in humans are summarized. In addition, preliminary data are given from an investigation of diet and a potent class of faecal genotoxins, the fecapentaenes. JF - Cancer surveys AU - Schiffman, M H AD - Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 653 EP - 672 VL - 6 IS - 4 SN - 0261-2429, 0261-2429 KW - Mutagens KW - 0 KW - Index Medicus KW - Mutagens -- analysis KW - Colonic Neoplasms -- etiology KW - Humans KW - Rectal Neoplasms -- etiology KW - Feces -- analysis KW - Mutagenicity Tests KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78019031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+surveys&rft.atitle=Diet+and+faecal+genotoxicity.&rft.au=Schiffman%2C+M+H&rft.aulast=Schiffman&rft.aufirst=M&rft.date=1987-01-01&rft.volume=6&rft.issue=4&rft.spage=653&rft.isbn=&rft.btitle=&rft.title=Cancer+surveys&rft.issn=02612429&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-01 N1 - Date created - 1988-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Carcinogenicity and mutagenicity of N-nitroso compounds. AN - 78005936; 3329700 AB - The carcinogenic activities in rats and hamsters and the mutagenic activity in Salmonella of a number of N-nitroso compounds belonging to various classes have been compared. While most directly acting N-nitroso compounds and those requiring metabolic activation are mutagenic with appropriate activation and seem to alkylate DNA in vivo, there are exceptions. Some of these are mutagens that are not carcinogenic; others are carcinogens that are nonmutagenic. Even among the mutagenic carcinogens, there is no quantitative relationship between mutagenic and carcinogenic activities. This implies to directly acting compounds and to those requiring metabolic activation. The lack of congruence between the two activities among the nitrosamines is due to the complexity of the metabolic activating processes leading to formation of proximate carcinogens. The deficiencies in the mutagenesis assay appear to arise from a lack of the necessary enzymes in the liver microsomal fractions used for activation. Nitrosamines bearing oxygen on the beta carbon of an alkyl chain are not oxidized by rat microsomal enzymes and hence are not converted to bacterial mutagens by rat liver microsomes. Bacterial mutagenicity is not a guide to carcinogenic activity of N-nitroso compounds or to the mechanisms by which these compounds induce cancer. JF - Molecular toxicology AU - Lijinsky, W AD - NCI-Frederick Cancer Research Facility, LBI-Basic Research Program, Maryland 21701. PY - 1987 SP - 107 EP - 119 VL - 1 IS - 1 SN - 0883-9492, 0883-9492 KW - Carcinogens KW - 0 KW - Mutagens KW - Nitroso Compounds KW - Index Medicus KW - Rats KW - Animals KW - Mutagenicity Tests KW - Biotransformation KW - Microsomes, Liver -- metabolism KW - Salmonella typhimurium -- drug effects KW - Neoplasms, Experimental -- pathology KW - Species Specificity KW - Structure-Activity Relationship KW - Cricetinae KW - Nitroso Compounds -- toxicity KW - Nitroso Compounds -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78005936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+toxicology&rft.atitle=Carcinogenicity+and+mutagenicity+of+N-nitroso+compounds.&rft.au=Lijinsky%2C+W&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1987-01-01&rft.volume=1&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Molecular+toxicology&rft.issn=08839492&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-14 N1 - Date created - 1988-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Development of an immunotoxin with in vivo efficacy for murine systems. AN - 78001521; 3327410 JF - Annals of the New York Academy of Sciences AU - Marsh, J W AU - Neville, D M AD - Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 165 EP - 171 VL - 507 SN - 0077-8923, 0077-8923 KW - Diphtheria Toxin KW - 0 KW - Immunotoxins KW - Peptide Fragments KW - Protein Synthesis Inhibitors KW - diphtheria toxin fragment A KW - Ammonia KW - 7664-41-7 KW - Index Medicus KW - Ammonia -- pharmacology KW - Drug Screening Assays, Antitumor KW - Animals KW - Tumor Cells, Cultured -- drug effects KW - Protein Synthesis Inhibitors -- therapeutic use KW - Mice KW - Immunotoxins -- immunology KW - Immunotoxins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78001521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Development+of+an+immunotoxin+with+in+vivo+efficacy+for+murine+systems.&rft.au=Marsh%2C+J+W%3BNeville%2C+D+M&rft.aulast=Marsh&rft.aufirst=J&rft.date=1987-01-01&rft.volume=507&rft.issue=&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-20 N1 - Date created - 1988-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunotoxins for in vivo therapy: where are we? AN - 77987289; 2831768 JF - Annals of the New York Academy of Sciences AU - Neville, D M AD - Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, Maryland 20894. Y1 - 1987 PY - 1987 DA - 1987 SP - 155 EP - 164 VL - 507 SN - 0077-8923, 0077-8923 KW - Diphtheria Toxin KW - 0 KW - Immunotoxins KW - Receptors, Cell Surface KW - Ribosomal Proteins KW - Index Medicus KW - Receptors, Cell Surface -- metabolism KW - Animals KW - Ribosomal Proteins -- metabolism KW - Kinetics KW - Cell Compartmentation KW - Diphtheria Toxin -- pharmacokinetics KW - Models, Biological KW - Immunotoxins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77987289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Immunotoxins+for+in+vivo+therapy%3A+where+are+we%3F&rft.au=Neville%2C+D+M&rft.aulast=Neville&rft.aufirst=D&rft.date=1987-01-01&rft.volume=507&rft.issue=&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-20 N1 - Date created - 1988-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metal- and metalloid-induced porphyrinurias. Relationships to cell injury. AN - 77986786; 3442382 JF - Annals of the New York Academy of Sciences AU - Fowler, B A AU - Oskarsson, A AU - Woods, J S AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987 PY - 1987 DA - 1987 SP - 172 EP - 182 VL - 514 SN - 0077-8923, 0077-8923 KW - Arsenates KW - 0 KW - Metals KW - Porphyrins KW - Lead KW - 2P299V784P KW - Mercury KW - FXS1BY2PGL KW - arsenic acid KW - N7CIZ75ZPN KW - Index Medicus KW - Animals KW - Kidney Tubules -- pathology KW - Lead -- toxicity KW - Kidney Tubules -- drug effects KW - Arsenates -- toxicity KW - Microscopy, Electron KW - Mercury -- toxicity KW - Porphyrias -- pathology KW - Porphyrins -- urine KW - Porphyrias -- chemically induced KW - Metals -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77986786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Metal-+and+metalloid-induced+porphyrinurias.+Relationships+to+cell+injury.&rft.au=Fowler%2C+B+A%3BOskarsson%2C+A%3BWoods%2C+J+S&rft.aulast=Fowler&rft.aufirst=B&rft.date=1987-01-01&rft.volume=514&rft.issue=&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-20 N1 - Date created - 1988-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regulated expression of differentiation-associated keratins in cultured epidermal cells detected by monospecific antibodies to unique peptides of mouse epidermal keratins. AN - 77974059; 2450799 AB - Monospecific antibodies to mouse epidermal keratins were generated in rabbits and guinea pigs by injecting synthetic peptides of unique keratin sequences. The sequences were deduced from nucleotide sequences of cDNA clones representing basal (K14) and suprabasal (K1 and K10) cell-specific and hyperproliferative (K6) keratins of both the type-I and type-II subclasses. By applying single-and double-label immunofluorescence analysis, the expression of keratin peptides was analyzed in cultured keratinocytes maintained in the basal or suprabasal cell phenotypes. These cell types were selected by growth in medium containing 0.05 mM Ca2+ (basal cell) or 1.4 mM Ca2+ (suprabasal cell). The cultured basal cells expressed K6 and K14, but less than 1% expressed K1 and K10. Within a few hours after being placed in 1.4 mM Ca2+, K1 expression was observed, and by 24 h, 10%-17% of the cells expressed K1. K10 expression appeared to lag behind K1 expression, with only 5%-10% of cells in 1.4 mM Ca2+ exhibiting K10 immunoreactivity. Double-labeling studies indicated that virtually all K10-positive cells also expressed K1, while only about one-half of the K1-positive cells expressed K10. The treatment of basal cells with retinoic acid at pharmacological concentrations prevented the expression of K1 and K10 when cells were challenged by 1.4 mM Ca2+. Similarly, the introduction of the v-rasH oncogene into basal cells by a defective retroviral vector prevented the expression of suprabasal keratins in 1.4 mM Ca2+ medium.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Differentiation; research in biological diversity AU - Roop, D R AU - Huitfeldt, H AU - Kilkenny, A AU - Yuspa, S H AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 143 EP - 150 VL - 35 IS - 2 SN - 0301-4681, 0301-4681 KW - Antibodies, Monoclonal KW - 0 KW - Keratins KW - 68238-35-7 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Dimethyl Sulfoxide -- pharmacology KW - Animals, Newborn KW - Animals KW - Cells, Cultured KW - Kinetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Mice KW - Mice, Inbred BALB C KW - Cell Differentiation -- drug effects KW - Fluorescent Antibody Technique KW - Keratins -- genetics KW - Epidermis -- drug effects KW - Epidermis -- cytology KW - Keratins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77974059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Differentiation%3B+research+in+biological+diversity&rft.atitle=Regulated+expression+of+differentiation-associated+keratins+in+cultured+epidermal+cells+detected+by+monospecific+antibodies+to+unique+peptides+of+mouse+epidermal+keratins.&rft.au=Roop%2C+D+R%3BHuitfeldt%2C+H%3BKilkenny%2C+A%3BYuspa%2C+S+H&rft.aulast=Roop&rft.aufirst=D&rft.date=1987-01-01&rft.volume=35&rft.issue=2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Differentiation%3B+research+in+biological+diversity&rft.issn=03014681&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-25 N1 - Date created - 1988-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Assessment of the risks associated with the use of chemical carcinogens in biomedical research. AN - 77971464; 3327629 AB - Estimates of occupational exposure to chemical carcinogens in biomedical research based on environmental monitoring data, efficiency of containment devices, and accident data suggest that workers may be exposed to a few tenths of a microgram of these carcinogens per work day. Environmental exposure to carcinogenic polycyclic aromatic hydrocarbons and N-nitroso compounds exceeds one microgram per day. Because occupational exposure to chemical carcinogens in the laboratory can be readily controlled and because environmental exposure appears to be greater than the occupational exposure that does occur, the relative risk of occupational exposure does not seem to constitute a major health problem. JF - Cancer metastasis reviews AU - Sansone, E B AD - Environmental Control and Research Program, NCI-Frederick Cancer Research Facility, MD 21701-1013. Y1 - 1987 PY - 1987 DA - 1987 SP - 481 EP - 488 VL - 6 IS - 4 SN - 0167-7659, 0167-7659 KW - Air Pollutants, Occupational KW - 0 KW - Carcinogens KW - Nitroso Compounds KW - Polycyclic Compounds KW - Index Medicus KW - Risk KW - Humans KW - Environmental Exposure KW - Nitroso Compounds -- adverse effects KW - Polycyclic Compounds -- adverse effects KW - Occupational Diseases -- chemically induced KW - Air Pollutants, Occupational -- adverse effects KW - Research KW - Carcinogens -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77971464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+metastasis+reviews&rft.atitle=Assessment+of+the+risks+associated+with+the+use+of+chemical+carcinogens+in+biomedical+research.&rft.au=Sansone%2C+E+B&rft.aulast=Sansone&rft.aufirst=E&rft.date=1987-01-01&rft.volume=6&rft.issue=4&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Cancer+metastasis+reviews&rft.issn=01677659&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-02 N1 - Date created - 1988-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biological evaluation of compounds for their physical dependence potential and abuse liability. X. Drug testing programs of the Committee on Problems of Drug Dependence, Inc. (1986). AN - 77961438; 2893982 JF - NIDA research monograph AU - Jacobson, A E AD - Medicinal Chemistry Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 370 EP - 391 VL - 76 SN - 1046-9516, 1046-9516 KW - Appetite Depressants KW - 0 KW - Bridged-Ring Compounds KW - Narcotics KW - Meptazinol KW - 18Y7S5JKZD KW - 3,4-Methylenedioxyamphetamine KW - 4764-17-4 KW - Naltrexone KW - 5S6W795CQM KW - NIH 10366 KW - 96453-66-6 KW - NIH 10367 KW - 96453-67-7 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - nalmefene KW - TOV02TDP9I KW - Index Medicus KW - Animals KW - Chemistry KW - 3,4-Methylenedioxyamphetamine -- analogs & derivatives KW - Naltrexone -- analogs & derivatives KW - Chemical Phenomena KW - Bridged-Ring Compounds -- adverse effects KW - Substance-Related Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77961438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Biological+evaluation+of+compounds+for+their+physical+dependence+potential+and+abuse+liability.+X.+Drug+testing+programs+of+the+Committee+on+Problems+of+Drug+Dependence%2C+Inc.+%281986%29.&rft.au=Jacobson%2C+A+E&rft.aulast=Jacobson&rft.aufirst=A&rft.date=1987-01-01&rft.volume=76&rft.issue=&rft.spage=370&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-29 N1 - Date created - 1988-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Therapy of cancer using the adoptive transfer of activated killer cells and interleukin-2. AN - 77933832; 3124451 AB - A new approach to cancer treatment has been developed based on the adoptive transfer of activated lymphocytes into cancer patients. Lymphocytes harvested from patients by leukapheresis are converted into lymphokine-activated killer (LAK) cells by incubation with recombinant interleukin-2 (rIL-2). These LAK cells are then infused back into the patients in combination with intravenous IL-2. Among 25 patients treated with this form of adoptive immunotherapy there were 11 patients with measurable tumor reductions, including 1 complete responder. The majority of responses occurred in patients with metastatic renal cell carcinoma, melanoma and colorectal carcinoma. The toxicities of IL-2, including fluid retention and pulmonary edema, limit therapy, and laboratory investigation is now aimed toward understanding the mechanism of IL-2 toxicity. The use of LAK cells and IL-2 in cancer therapy is still in a developmental stage and needs to be refined before its role can be definitely established. JF - Acta haematologica AU - Topalian, S L AU - Rosenberg, S A AD - Surgery Branch, National Cancer Institute, Bethesda, Md. Y1 - 1987 PY - 1987 DA - 1987 SP - 75 EP - 76 VL - 78 Suppl 1 SN - 0001-5792, 0001-5792 KW - Interleukin-2 KW - 0 KW - Recombinant Proteins KW - Index Medicus KW - Recombinant Proteins -- pharmacology KW - Combined Modality Therapy KW - Humans KW - Pulmonary Edema -- chemically induced KW - Clinical Trials as Topic KW - Kidney Diseases -- chemically induced KW - Interleukin-2 -- pharmacology KW - Killer Cells, Natural -- transplantation KW - Interleukin-2 -- adverse effects KW - Interleukin-2 -- administration & dosage KW - Interleukin-2 -- therapeutic use KW - Immunization, Passive KW - Neoplasms -- therapy KW - Killer Cells, Natural -- immunology KW - Killer Cells, Natural -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77933832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+haematologica&rft.atitle=Therapy+of+cancer+using+the+adoptive+transfer+of+activated+killer+cells+and+interleukin-2.&rft.au=Topalian%2C+S+L%3BRosenberg%2C+S+A&rft.aulast=Topalian&rft.aufirst=S&rft.date=1987-01-01&rft.volume=78+Suppl+1&rft.issue=&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Acta+haematologica&rft.issn=00015792&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-08 N1 - Date created - 1988-03-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Basic and clinical immunology in uveitis. AN - 77928774; 3430854 AB - Understanding the basic immune mechanisms and how they relate to the eye are becoming obtainable goals with far reaching implications. Attempts are made to classically divide the immune responses noted into Type I-IgE mediated, Type II-Antibody mediated killing, Type III-Immune complex mediation, and Type IV-Cell mediated. Though several mechanisms are surely working simultaneously, it remains an helpful method of analysis. Until recently, Type III hypersensitivity reactions were thought to be the basic underlying cause of most ocular inflammatory disease, but recent evidence would suggest that cell mediated mechanisms are more important for sight threatening ocular disease (uveitis). The S-antigen and IRBP induced experimental models for uveitis have provided us with invaluable information concerning the potential mechanisms underpinning uveitis, while the diseases themselves manifest many aspects of that seen in human disease. Additionally, it has permitted us to investigate the way in which immune cells may "home" to a target organ, this in part due to the expression of HLA antigens on non-immune tissues in the eye. The observation that T-cell mechanisms appear of major import in uveitis permitted a new approach to therapy, the use of the anti-T-cell drug cyclosporine. Its use in severe sight threatening disease has shown it to be effective, thereby confirming the notion of the importance of T-cell mediation of these diseases. Perhaps most notable is this agent's efficacy in the treatment of Behçet uveitis. The problem of renal toxicity has been addressed by using cyclosporine in combination with other agents, including those not directly affecting the immune system.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Japanese journal of ophthalmology AU - Nussenblatt, R B AD - National Eye Institute, NIH, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 368 EP - 374 VL - 31 IS - 3 SN - 0021-5155, 0021-5155 KW - Antigens KW - 0 KW - Arrestin KW - Cyclosporins KW - Eye Proteins KW - Bromocriptine KW - 3A64E3G5ZO KW - Index Medicus KW - Cyclosporins -- adverse effects KW - Animals KW - Humans KW - Bromocriptine -- therapeutic use KW - Cyclosporins -- therapeutic use KW - Antibody Formation KW - Disease Models, Animal KW - Cyclosporins -- administration & dosage KW - Bromocriptine -- administration & dosage KW - Eye Proteins -- immunology KW - Biomechanical Phenomena KW - Immune System -- physiology KW - Antigens -- immunology KW - Allergy and Immunology -- trends KW - Uveitis -- immunology KW - Uveitis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77928774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Japanese+journal+of+ophthalmology&rft.atitle=Basic+and+clinical+immunology+in+uveitis.&rft.au=Nussenblatt%2C+R+B&rft.aulast=Nussenblatt&rft.aufirst=R&rft.date=1987-01-01&rft.volume=31&rft.issue=3&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Japanese+journal+of+ophthalmology&rft.issn=00215155&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-29 N1 - Date created - 1988-02-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Retinoic acid inhibits migration of cranial neural crest cells in the cultured mouse embryo. AN - 77927211; 3429604 AB - Clinical observations have demonstrated that isotretinoin (13-cis-retinoic acid; cis-RA) is a human teratogen causing primarily heart and craniofacial malformations. Isotretinoin exposure to the early postimplantation mouse embryo in culture results in specific defects in craniofacial development that may be due to an interference in the early migration of cranial neural crest (CNC) cells [Goulding and Pratt, 1986]. The present study was designed to test this hypothesis by examining the migration of these cells in whole embryo culture. Day 8 CD-1 mouse embryos were cultured for 6-48 hr in the presence or absence of cis-RA at 2 X 10(-6) to 2 X 10(-5) M. Embryos either were fixed for light microscopy using Nichols' method for localization of CNC cells or were processed for scanning and transmission electron microscopy. At the light microscopic level, CNC cells in the mid-brain region of control embryos had migrated to the region of the first and second visceral arches after 6 hr in culture. Cis-RA interfered with this migration; CNC cells in treated embryos either did not leave the neuroepithelium (NE) or were aggregated near the NE. Autoradiographic studies indicated that cis-RA did not affect the overall viability or DNA synthesis of the CNC cells. However, at the TEM level, there was a dramatic increase in the number of cellular blebs in the CNC cells. Our results demonstrate a direct effect of 13-cis-RA on the CNC cells and suggest that this effect is due to alterations in the cell surface. JF - Journal of craniofacial genetics and developmental biology AU - Pratt, R M AU - Goulding, E H AU - Abbott, B D AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987 PY - 1987 DA - 1987 SP - 205 EP - 217 VL - 7 IS - 3 SN - 0270-4145, 0270-4145 KW - Teratogens KW - 0 KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Animals KW - Embryonic and Fetal Development KW - Cell Movement -- drug effects KW - Mice KW - Embryo, Mammalian -- ultrastructure KW - Autoradiography KW - Embryo, Mammalian -- drug effects KW - Skull -- embryology KW - Neural Crest -- drug effects KW - Tretinoin -- toxicity KW - Teratogens -- toxicity KW - Skull -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77927211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+craniofacial+genetics+and+developmental+biology&rft.atitle=Retinoic+acid+inhibits+migration+of+cranial+neural+crest+cells+in+the+cultured+mouse+embryo.&rft.au=Pratt%2C+R+M%3BGoulding%2C+E+H%3BAbbott%2C+B+D&rft.aulast=Pratt&rft.aufirst=R&rft.date=1987-01-01&rft.volume=7&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Journal+of+craniofacial+genetics+and+developmental+biology&rft.issn=02704145&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-21 N1 - Date created - 1988-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Trimetrexate: clinical development of a nonclassical antifolate. AN - 77924179; 2963228 AB - Trimetrexate is a 2,4-diaminoquinazoline inhibitor of dihydrofolate reductase (DHFR) which is cytotoxic in vitro and in vivo to several tumors resistant to methotrexate. It is more lipophilic than the parent antifolate, and is not transported by the reduced folate carrier. These features promise activity greater than that of methotrexate in the clinic; its inability to undergo polyglutamylation may also enhance the therapeutic index. In preclinical models, the activity of trimetrexate was highly schedule dependent, being superior on repeated dose schedules. Phase I studies have demonstrated that myelosuppression is the major toxic effect of trimetrexate on all schedules tested in man. Phase II studies will evaluate a 5-day schedule initially; trials in multiple tumor types and examination of the role of schedule are already under way. JF - NCI monographs : a publication of the National Cancer Institute AU - O'Dwyer, P J AU - DeLap, R J AU - King, S A AU - Grillo-Lopez, A J AU - Hoth, D F AU - Leyland-Jones, B AD - Investigational Drug Branch, National Cancer Institute, Bethesda, MD. Y1 - 1987 PY - 1987 DA - 1987 SP - 105 EP - 109 IS - 5 SN - 0893-2751, 0893-2751 KW - Folic Acid Antagonists KW - 0 KW - Quinazolines KW - Trimetrexate KW - UPN4ITI8T4 KW - Index Medicus KW - Drug Evaluation KW - Animals KW - Drug Administration Schedule KW - Leukemia P388 -- drug therapy KW - Humans KW - Mice KW - Structure-Activity Relationship KW - Biological Availability KW - Quinazolines -- pharmacokinetics KW - Neoplasms -- drug therapy KW - Quinazolines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77924179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.atitle=Trimetrexate%3A+clinical+development+of+a+nonclassical+antifolate.&rft.au=O%27Dwyer%2C+P+J%3BDeLap%2C+R+J%3BKing%2C+S+A%3BGrillo-Lopez%2C+A+J%3BHoth%2C+D+F%3BLeyland-Jones%2C+B&rft.aulast=O%27Dwyer&rft.aufirst=P&rft.date=1987-01-01&rft.volume=&rft.issue=5&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.issn=08932751&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-04 N1 - Date created - 1988-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Preliminary results of a phase II trial for the treatment of metastatic breast cancer with 5-fluorouracil and leucovorin. AN - 77923771; 3501543 AB - The active metabolite of FUra, 5-fluorodeoxyuridine monophosphate (5-FdUMP), requires the presence of reduced folates to form a covalent ternary complex with the target enzyme thymidylate synthase (TS). In vitro and in vivo studies have demonstrated a potentiation of the cytotoxic effects of FUra when combined with the reduced folate, leucovorin. We have applied this concept to the treatment of metastatic breast cancer in a phase II trial, as recent clinical studies on patients with colorectal carcinoma have suggested an enhanced efficacy for the combination of FUra plus leucovorin. Patients entered on the present study are undergoing treatment with a 5-day daily regimen of leucovorin (500 mg/m2, iv) followed by FUra (375 mg/m2, iv). Toxicity and response data are currently being collected on patients who have failed "standard" combination regimens that included FUra. In patients with accessible tumor, serial biopsies are being obtained during treatment with the combination of FUra and leucovorin and during therapy with FUra alone to assess the degree of 5-FdUMP binding to the target enzyme, TS, in the presence and absence of exogenously administered leucovorin. Preliminary results from the biochemical studies suggest an enhanced saturation of TS by the fluorinated pyrimidine when administered with leucovorin. JF - NCI monographs : a publication of the National Cancer Institute AU - Allegra, C J AU - Chabner, B A AU - Sholar, P W AU - Bagley, C AU - Drake, J C AU - Lippman, M E AD - Clinical Pharmacology Branch, National Cancer Institute, Bethesda, MD 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 199 EP - 202 IS - 5 SN - 0893-2751, 0893-2751 KW - Fluorodeoxyuridylate KW - 134-46-3 KW - Folic Acid KW - 935E97BOY8 KW - Thymidylate Synthase KW - EC 2.1.1.45 KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Drug Evaluation KW - Folic Acid -- metabolism KW - Humans KW - Fluorodeoxyuridylate -- metabolism KW - Adult KW - Neoplasm Metastasis KW - Middle Aged KW - Thymidylate Synthase -- metabolism KW - Fluorouracil -- administration & dosage KW - Breast Neoplasms -- drug therapy KW - Leucovorin -- administration & dosage KW - Breast Neoplasms -- enzymology KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77923771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.atitle=Preliminary+results+of+a+phase+II+trial+for+the+treatment+of+metastatic+breast+cancer+with+5-fluorouracil+and+leucovorin.&rft.au=Allegra%2C+C+J%3BChabner%2C+B+A%3BSholar%2C+P+W%3BBagley%2C+C%3BDrake%2C+J+C%3BLippman%2C+M+E&rft.aulast=Allegra&rft.aufirst=C&rft.date=1987-01-01&rft.volume=&rft.issue=5&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=NCI+monographs+%3A+a+publication+of+the+National+Cancer+Institute&rft.issn=08932751&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-04 N1 - Date created - 1988-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Proliferative exocrine pancreatic lesions in rats. The effect of sample size on the incidence of lesions. AN - 77923641; 3432946 AB - Pancreatic tissue from untreated and corn oil gavage control rats in four chronic (2-year) toxicity and carcinogenicity studies was examined microscopically for the presence of acinar hyperplasia, acinar adenoma, and acinar carcinoma. Formalin-fixed pancreatic tissue that had been saved from these rats was then examined for grossly visible lesions; and all additional available pancreatic tissue was embedded, routinely processed, and sectioned at 5-7 microns for histopathological examination. There were no additional gross lesions identified in the review of the residual tissues. However, microscopic examination of this additional tissue resulted in a marked increase in the number of proliferative lesions diagnosed. The incidence of acinar cell adenomas increased from 1/188 (0.5%) to 28/193 (15%) in untreated control male rats and from 8/194 (4%) to 73/195 (37%) in corn oil gavage vehicle control male rats. There were similar increases in hyperplasia in vehicle and untreated male rats, and similar but much less dramatic increases in hyperplasia and adenoma in vehicle and untreated control female rats. The previously reported effect of increased proliferative lesions of the exocrine pancreas of male rats given corn oil vehicle was confirmed. In addition, examination of a larger tissue sample identified a similar but smaller effect of the corn oil vehicle in female F344 rats that had not been detected by routine sampling of the pancreas. JF - Toxicologic pathology AU - Boorman, G A AU - Banas, D A AU - Eustis, S L AU - Haseman, J K AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1987 PY - 1987 DA - 1987 SP - 451 EP - 456 VL - 15 IS - 4 SN - 0192-6233, 0192-6233 KW - Plant Oils KW - 0 KW - Corn Oil KW - 8001-30-7 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Hyperplasia KW - Sex Factors KW - Adenoma -- chemically induced KW - Male KW - Female KW - Pancreas -- pathology KW - Pancreatic Neoplasms -- pathology KW - Plant Oils -- toxicity KW - Pancreatic Neoplasms -- chemically induced KW - Corn Oil -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77923641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Proliferative+exocrine+pancreatic+lesions+in+rats.+The+effect+of+sample+size+on+the+incidence+of+lesions.&rft.au=Boorman%2C+G+A%3BBanas%2C+D+A%3BEustis%2C+S+L%3BHaseman%2C+J+K&rft.aulast=Boorman&rft.aufirst=G&rft.date=1987-01-01&rft.volume=15&rft.issue=4&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-14 N1 - Date created - 1988-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Retinoids and epidermal growth factor alter embryonic mouse palatal epithelial and mesenchymal cell differentiation in organ culture. AN - 77921600; 3501431 AB - The mechanism by which retinoids (RA) induce cleft palate is not known. During normal palatogenesis, the medial epithelia of opposing palatal shelves cease DNA synthesis, come into contact, adhere, and undergo programmed cell death (PCD). In organ cultures of day 12 embryonic mouse palatal shelves, epidermal growth factor (EGF) blocks PCD, and DNA synthesis continues. In the present study, the effects of trans-RA, 13-cis-RA, EGF, and combinations of EGF and RA on surface morphology, DNA synthesis, and cellular ultrastructure are determined for CD-1 embryonic mouse palatal shelves cultured on day 12 of gestation. DNA synthesis in the medial cells was sustained and PCD was blocked by EGF, trans-RA, and 13-cis-RA. Exposure to trans-RA, but not to 1-cis-RA, induced the medial epithelia to undergo hyperplasia, and addition of EGF enhanced the effect. In the presence of RA, particularly trans-RA, medial epithelial cells acquired nasal cell characteristics, and EGF enhanced this effect. Expansion of the mesenchymal extracellular spaces was blocked by trans-RA and to a lesser degree by 13-cis-RA. The RA-induced alterations in normal epithelial and mesenchymal cell differentiation may be relevant to the etiology of RA-induced cleft palate in vivo. JF - Journal of craniofacial genetics and developmental biology AU - Abbott, B D AU - Pratt, R M AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987 PY - 1987 DA - 1987 SP - 219 EP - 240 VL - 7 IS - 3 SN - 0270-4145, 0270-4145 KW - Retinoids KW - 0 KW - Teratogens KW - Epidermal Growth Factor KW - 62229-50-9 KW - Index Medicus KW - Animals KW - Epithelial Cells KW - Microscopy, Electron KW - Mice KW - Autoradiography KW - Organ Culture Techniques KW - Epithelium -- drug effects KW - Microscopy, Electron, Scanning KW - Palate -- drug effects KW - Retinoids -- toxicity KW - Teratogens -- toxicity KW - Epidermal Growth Factor -- pharmacology KW - Palate -- embryology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77921600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+craniofacial+genetics+and+developmental+biology&rft.atitle=Retinoids+and+epidermal+growth+factor+alter+embryonic+mouse+palatal+epithelial+and+mesenchymal+cell+differentiation+in+organ+culture.&rft.au=Abbott%2C+B+D%3BPratt%2C+R+M&rft.aulast=Abbott&rft.aufirst=B&rft.date=1987-01-01&rft.volume=7&rft.issue=3&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Journal+of+craniofacial+genetics+and+developmental+biology&rft.issn=02704145&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-21 N1 - Date created - 1988-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Further classification of skin alkaloids from neotropical poison frogs (Dendrobatidae), with a general survey of toxic/noxious substances in the amphibia. AN - 77920886; 3321567 AB - Cutaneous granular glands are a shared character of adult amphibians, including caecilians, and are thought to be the source of most biologically active compounds in amphibian skin. Data are available from one or more species in over 100 of nearly 400 genera comprising the three living orders of Amphibia. Many species contain unidentified substances judged to be noxious based on predator aversion or human taste. Additionally, there is a great diversity of known compounds, some highly toxic as well as noxious, which can be tabulated under four broad categories: biogenic amines, peptides, bufodienolides (bufogenins) and alkaloids. The last category includes alkaloids derived from biogenic amines, water-soluble alkaloids (tetrodotoxins) and lipophilic alkaloids. Most compounds are known only from skin of adult amphibians, but the toxic and noxious properties of eggs and larvae of certain salamanders and toads can be attributed to tetrodotoxins and bufodienolides, which occur also in adult tissues other than skin. Predator aversion and various antipredator behaviors and aposematic colorations clearly prove the defensive value of these diverse metabolites, whether or not they are elaborated primarily (e.g. alkaloids) or secondarily (e.g. some peptides and biogenic amines) for this function. Lipophilic alkaloids include the samandarine alkaloids, known definitely only from an Old World genus of salamanders, and the more than 200 dendrobatid alkaloids. Nearly all the latter are unique to neotropical poison frogs of the genera Dendrobates and Phyllobates (Dendrobatidae), except for seemingly homoplastic occurrences of a few such alkaloids in small brightly colored anurans of several other families. Owing to recent discoveries and new structural information, the dendrobatid alkaloids are here partitioned among the following major and minor classes: batrachotoxins, histrionicotoxins, indolizidines, pumiliotoxin-A class and its allopumiliotoxin and homopumiliotoxin subclasses, decahydroquinolines, gephyrotoxins, 2,6-disubstituted piperidines, 2,5-disubstituted pyrrolidines, pyridyl-piperidines, indole alkaloids, azatricyclododecenes and amidine alkaloids. Except for the steroidal batrachotoxins, and the minor classes of pyrrolidine alkaloids, indole alkaloids and amidine alkaloids, all the above contain a piperidine ring. A large number of piperidine-based alkaloids occur mainly as trace compounds in Dendrobates and remain unclassified; the only water-soluble toxin so far discovered in a dendrobatid (Colostethus) is structurally unknown, but conceivably an alkaloid. JF - Toxicon : official journal of the International Society on Toxinology AU - Daly, J W AU - Myers, C W AU - Whittaker, N AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 1023 EP - 1095 VL - 25 IS - 10 SN - 0041-0101, 0041-0101 KW - Alkaloids KW - 0 KW - Index Medicus KW - Animals KW - Amphibians -- physiology KW - Skin -- analysis KW - Alkaloids -- toxicity KW - Alkaloids -- classification KW - Alkaloids -- analysis KW - Anura -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77920886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Further+classification+of+skin+alkaloids+from+neotropical+poison+frogs+%28Dendrobatidae%29%2C+with+a+general+survey+of+toxic%2Fnoxious+substances+in+the+amphibia.&rft.au=Daly%2C+J+W%3BMyers%2C+C+W%3BWhittaker%2C+N&rft.aulast=Daly&rft.aufirst=J&rft.date=1987-01-01&rft.volume=25&rft.issue=10&rft.spage=1023&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-08 N1 - Date created - 1988-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcohol intoxication in humans: effects on vigilance performance. AN - 77914344; 3426761 AB - Effects of ethanol on vigilance in tasks requiring continuous performance are reviewed. Evidence is presented to indicate that ethanol has adverse effects on both the overall level of performance and the rate of performance decrement over time. The effects on performance level are attributed to nonspecific sedative properties of ethanol whereas the effects on rate of decrement are interpreted as a more specific loss in cognitive processing capacity. JF - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement AU - Rohrbaugh, J AU - Stapleton, J M AU - Parasuraman, R AU - Frowein, H AU - Eckardt, M J AU - Linnoila, M AD - Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 97 EP - 102 VL - 1 SN - 1358-6173, 1358-6173 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Sex Factors KW - Ethanol -- pharmacology KW - Dose-Response Relationship, Drug KW - Humans KW - Male KW - Female KW - Alcoholic Intoxication -- psychology KW - Attention -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77914344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.atitle=Alcohol+intoxication+in+humans%3A+effects+on+vigilance+performance.&rft.au=Rohrbaugh%2C+J%3BStapleton%2C+J+M%3BParasuraman%2C+R%3BFrowein%2C+H%3BEckardt%2C+M+J%3BLinnoila%2C+M&rft.aulast=Rohrbaugh&rft.aufirst=J&rft.date=1987-01-01&rft.volume=1&rft.issue=&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.issn=13586173&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human embryonic palatal epithelial differentiation is altered by retinoic acid and epidermal growth factor in organ culture. AN - 77913558; 3501432 AB - Reports of adverse human pregnancy outcomes including cleft palate have increased as the clinical use of isotretinoin (13-cis-retinoic acid) and other retinoic acid (RA) derivatives have increased, but the mechanisms by which their effects are exerted are not understood. Research in craniofacial development is generally performed in rodents, and mouse palatal shelves exposed in organ cultures to retinoids and epidermal growth factor (EGF) display altered medial epithelial cell morphology blocking normal union of apposing shelves. In the present study, precontacting human palatal shelves were maintained in organ culture for 2, 3, or 6 days and exposed to labeled thymidine (3H-TdR) during the last 16 hr. Retinoids and EGF were included in the media so that each shelf was exposed to one of the following: control, EGF, trans-RA at 10(-5)M, cis-RA at 10(-7) or 10(-9) M, or RA + EGF. After exposure of cultured human embryonic palatal shelves to 13-cis-RA and trans-RA with or without EGF, medial epithelial cells do not degenerate, cell surface morphology shifts toward a nasal type, glycogen deposits decrease, smooth endoplasmic reticulum (SER) increases, and basal lamina appear altered. In shelves exposed to EGF and trans-RA early in their development, DNA synthesis appears to terminate prematurely as compared to shelves cultured in control media, and this effect is accompanied by excessive mesenchymal extracellular space expansion. Exposure of shelves to EGF alone is sufficient to block degeneration and induce hyperplasia of the medial epithelial cells but does not induce other ultrastructural changes seen with both EGF and RA. The observed alterations in medial cell morphology could interfere with adhesion of the palatal shelves and may play a role in retinoid-induced cleft palate in the human embryo. JF - Journal of craniofacial genetics and developmental biology AU - Abbott, B D AU - Pratt, R M AD - Experimental Teratogenesis Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987 PY - 1987 DA - 1987 SP - 241 EP - 265 VL - 7 IS - 3 SN - 0270-4145, 0270-4145 KW - Teratogens KW - 0 KW - Tretinoin KW - 5688UTC01R KW - Epidermal Growth Factor KW - 62229-50-9 KW - Index Medicus KW - Epithelial Cells KW - Humans KW - Cell Differentiation -- drug effects KW - Organ Culture Techniques KW - Epithelium -- drug effects KW - Embryonic and Fetal Development -- drug effects KW - Palate -- drug effects KW - Tretinoin -- toxicity KW - Palate -- cytology KW - Teratogens -- toxicity KW - Epidermal Growth Factor -- pharmacology KW - Palate -- embryology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77913558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+craniofacial+genetics+and+developmental+biology&rft.atitle=Human+embryonic+palatal+epithelial+differentiation+is+altered+by+retinoic+acid+and+epidermal+growth+factor+in+organ+culture.&rft.au=Abbott%2C+B+D%3BPratt%2C+R+M&rft.aulast=Abbott&rft.aufirst=B&rft.date=1987-01-01&rft.volume=7&rft.issue=3&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Journal+of+craniofacial+genetics+and+developmental+biology&rft.issn=02704145&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-21 N1 - Date created - 1988-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The measurement of 1,2-propanediol, D, L-2,3-butanediol and meso-2,3-butanediol in controls and alcoholic cirrhotics. AN - 77912718; 3426740 AB - Plasma 1,2-propanediol, D,L,-2,3-butanediol and 2,3-meso-butanediol were measured in 29 patients with biopsy proven alcoholic cirrhosis and 10 control subjects, none of whom had measurable blood alcohol levels. None of these compounds were present in control subjects at level above 5 nmol/ml. Seventeen (59%) of 29 serum samples drawn from patients with alcoholic cirrhosis contained 1,2-propanediol in concentrations above 5 nmol/ml (range less than 5.0 nmol/ml-35.4 nmol/ml, median 5.6), 8 (28%) of 29 samples contained D,L-2,3-butanediol in concentrations above 5.0 nmol/ml (range less than 5.0 nmol/ml-211 nmol/ml) and 7 (25%) of 29 samples contained meso-2,3-butanediol in concentrations above 5.0 nmol/ml (range less than 5.0-63.4 nmol/ml). In alcohol abstinent patients with alcoholic cirrhosis elevated serum 2,3-butanediol is due neither to ingestion of diols from undistilled alcoholic beverages nor is it likely to arise directly from the metabolic products of ethanol. In future studies on the origin of 2,3-butanediol in alcoholic patients biopsy evidence of the degree of associated liver damage should be obtained. JF - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement AU - Casazza, J P AU - Frietas, J AU - Stambuk, D AU - Morgan, M Y AU - Veech, R L AD - Laboratory of Metabolism and Molecular Biology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852. Y1 - 1987 PY - 1987 DA - 1987 SP - 607 EP - 609 VL - 1 SN - 1358-6173, 1358-6173 KW - Butylene Glycols KW - 0 KW - Propylene Glycols KW - Serum Albumin KW - Ethanol KW - 3K9958V90M KW - 2,3-butylene glycol KW - 45427ZB5IJ KW - Propylene Glycol KW - 6DC9Q167V3 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Bilirubin KW - RFM9X3LJ49 KW - Index Medicus KW - Aspartate Aminotransferases -- blood KW - Serum Albumin -- analysis KW - Ethanol -- pharmacology KW - Humans KW - Bilirubin -- analysis KW - Alkaline Phosphatase -- blood KW - Alcoholism -- blood KW - Liver Cirrhosis, Alcoholic -- blood KW - Propylene Glycols -- blood KW - Butylene Glycols -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77912718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.atitle=The+measurement+of+1%2C2-propanediol%2C+D%2C+L-2%2C3-butanediol+and+meso-2%2C3-butanediol+in+controls+and+alcoholic+cirrhotics.&rft.au=Casazza%2C+J+P%3BFrietas%2C+J%3BStambuk%2C+D%3BMorgan%2C+M+Y%3BVeech%2C+R+L&rft.aulast=Casazza&rft.aufirst=J&rft.date=1987-01-01&rft.volume=1&rft.issue=&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.issn=13586173&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Estrogen receptor stereochemistry: receptor binding and hormonal responses. AN - 77894715; 3695485 AB - Estrogen stimulation of the uterus elicits a spectrum of biochemical responses which are customarily linked together. DES and certain structural analogs, indenestrol A (IA), indenestrol B (IB), indanestrol (I), and pseudo DES (PD), were used as probes to segregate various genomic responses previously considered interrelated, most notably the events of specific protein synthesis, DNA synthesis, and mitosis. These compounds have poor uterotrophic activity; except for I, they interact specifically with mouse uterine estrogen receptors (ER) with high affinity. All translocate stoichiometrically similar amounts of ER complex to the nucleus. IA and IB possess a single chiral carbon atom and exist as a mixture of enantiomers (ENT). We investigated whether the poor biological activity of IA could be explained by differential activity of the enantiomers. The IA ENT were separated to greater than 98% purity using a chirally active HPLC column. Competitive binding assays to cytosolic ER demonstrated a stereochemical chiral preference. This preference was also evident from nuclear ER translocation experiments. IB was as active as DES to induce mouse uterine glucose 6-phosphate dehydrogenase (G-6-PD), while the other compounds had weak activity. Induction of cytosolic progesterone receptor (PR) was stimulated by all the DES compounds. Ornithine decarboxylase (ODC) was stimulated 600% by DES and 180% by IB; the other compounds had no significant activity. Uterine DNA synthesis was increased by DES and IB. Thymidine autoradiography indicated nuclear labeling was occurring primarily in luminal epithelium. Treatment with PD increased uterine cell height but not cell numbers, suggesting the two responses are not necessarily interdependent as previously thought and may require two separate receptor interactions. Such a probe should be useful in studying the individual events involved in estrogen-induced uterine growth. These data also indicate that induction of ER, PR and G-6-PD are not coupled. Therefore, stimulation of a certain uterine response may depend on the structure of the particular ligand receptor complex formed, and its interaction may be regulated by specificity at the genomic acceptor site. JF - Journal of steroid biochemistry AU - Korach, K S AU - Levy, L A AU - Sarver, P J AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1987 PY - 1987 DA - 1987 SP - 281 EP - 290 VL - 27 IS - 1-3 SN - 0022-4731, 0022-4731 KW - Indans KW - 0 KW - Indenes KW - Receptors, Estrogen KW - Receptors, Progesterone KW - indenestrol KW - 4A464K3BSI KW - Estradiol KW - 4TI98Z838E KW - indanestrol KW - 71855-45-3 KW - Diethylstilbestrol KW - 731DCA35BT KW - Glucosephosphate Dehydrogenase KW - EC 1.1.1.49 KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Index Medicus KW - Animals KW - Uterus KW - Stereoisomerism KW - Receptors, Progesterone -- biosynthesis KW - Mice, Inbred ICR KW - Diethylstilbestrol -- metabolism KW - Estradiol -- pharmacology KW - Biological Transport KW - Mice KW - Ornithine Decarboxylase -- biosynthesis KW - Protein Binding KW - Glucosephosphate Dehydrogenase -- biosynthesis KW - Indans -- metabolism KW - DNA Replication -- drug effects KW - Estradiol -- metabolism KW - Indenes -- pharmacology KW - Enzyme Induction -- drug effects KW - Binding, Competitive KW - Indans -- pharmacology KW - Diethylstilbestrol -- pharmacology KW - Diethylstilbestrol -- analogs & derivatives KW - Gene Expression Regulation -- drug effects KW - Indenes -- metabolism KW - Female KW - Receptors, Estrogen -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77894715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+steroid+biochemistry&rft.atitle=Estrogen+receptor+stereochemistry%3A+receptor+binding+and+hormonal+responses.&rft.au=Korach%2C+K+S%3BLevy%2C+L+A%3BSarver%2C+P+J&rft.aulast=Korach&rft.aufirst=K&rft.date=1987-01-01&rft.volume=27&rft.issue=1-3&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Journal+of+steroid+biochemistry&rft.issn=00224731&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prostaglandin involvement in ethanol's mechanism of action. AN - 77893165; 3426750 AB - Prostaglandin (PG) synthesis inhibitors antagonize behavioral responses to alcohols, suggesting PG involvement in the mechanism of action of alcohols. This report presents biochemical data indicating that ethanol increases in vivo brain PGE and PGF levels in Long Sleep (LS) and Short Sleep (SS) mice, with the LS mice showing the greatest ethanol-induced increases in PGE and PGF levels. Increases in brain PGE and PGF levels were highly correlated across dose and time with the absorption phase of ethanol. These results provide further evidence to support the hypothesis that ethanol produces its intoxicating effects to a significant degree through a prostaglandin mediated mechanism. JF - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement AU - George, F R AD - Preclinical Pharmacology Branch, National Institute on Drug Abuse, Baltimore, Maryland 21224. Y1 - 1987 PY - 1987 DA - 1987 SP - 675 EP - 678 VL - 1 SN - 1358-6173, 1358-6173 KW - Prostaglandins KW - 0 KW - Prostaglandins E KW - Prostaglandins F KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Dose-Response Relationship, Drug KW - Brain Chemistry -- drug effects KW - Prostaglandins F -- analysis KW - Prostaglandins E -- analysis KW - Alcoholism -- metabolism KW - Mice KW - Male KW - Female KW - Prostaglandins -- physiology KW - Ethanol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77893165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.atitle=Prostaglandin+involvement+in+ethanol%27s+mechanism+of+action.&rft.au=George%2C+F+R&rft.aulast=George&rft.aufirst=F&rft.date=1987-01-01&rft.volume=1&rft.issue=&rft.spage=675&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.issn=13586173&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Long-term retinoid therapy is needed for maintenance of cancer chemopreventive effect. AN - 77888661; 3480250 AB - Two patients with multiple basal cell carcinomas, due either to the nevoid basal cell carcinoma syndrome (NBCCS) or arsenical insecticide exposure, were treated with oral isotretinoin for 7 or 8 years, respectively. Gradually decreasing dosage levels were employed. During the initial courses of therapy, high doses (2.0-3.0 mg/kg/day) were intended as chemotherapy. In these patients only 6 of 40 (15%) lesions underwent complete clinical regression. In subsequent courses aimed at chemoprevention, the dose was progressively reduced from 1.5 to 0.25 mg/kg/day. During therapy, no new lesions were observed in the patient with the arsenical exposure. The NBCCS patient developed 1 new lesion during therapy at 1.0 mg/kg/day, 1 new lesion at 0.5 mg/kg/day and 5 new lesions at 0.25 mg/kg/day. Treatment was discontinued and the patient with the arsenic exposure developed his first new tumor 17 months afterwards; in contrast, the NBCCS patient developed 29 tumors within 13 months. These findings suggest that long-term therapy with isotretinoin is needed for the continuation of the cancer chemopreventive effect. However, the need for continuous rather than intermittent maintenance therapy, and the determination of the optimal dose for this purpose may depend on the etiology of the multiple carcinomas and on the tolerability of the lowest effective dose by the individual patient. With these encouraging data, it now appears appropriate to expand this pilot study and perform larger trials to determine the usefulness of isotretinoin in the chemoprevention of basal cell carcinoma in patients with multiple tumors. JF - Dermatologica AU - Peck, G L AD - Dermatology Branch, National Cancer Institute, Bethesda, Md. Y1 - 1987 PY - 1987 DA - 1987 SP - 138 EP - 144 VL - 175 Suppl 1 SN - 0011-9075, 0011-9075 KW - Tretinoin KW - 5688UTC01R KW - Isotretinoin KW - EH28UP18IF KW - Index Medicus KW - Humans KW - Prognosis KW - Middle Aged KW - Male KW - Skin Neoplasms -- drug therapy KW - Basal Cell Nevus Syndrome -- drug therapy KW - Neoplasms, Multiple Primary -- drug therapy KW - Skin Neoplasms -- chemically induced KW - Carcinoma, Basal Cell -- drug therapy KW - Basal Cell Nevus Syndrome -- chemically induced KW - Neoplasms, Multiple Primary -- chemically induced KW - Tretinoin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77888661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dermatologica&rft.atitle=Long-term+retinoid+therapy+is+needed+for+maintenance+of+cancer+chemopreventive+effect.&rft.au=Peck%2C+G+L&rft.aulast=Peck&rft.aufirst=G&rft.date=1987-01-01&rft.volume=175+Suppl+1&rft.issue=&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Dermatologica&rft.issn=00119075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-29 N1 - Date created - 1988-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inducible responses to DNA damage in bacteria and mammalian cells. AN - 77885249; 2826138 JF - Environmental and molecular mutagenesis AU - Elespuru, R K AD - Laboratory of Chemical and Physical Carcinogenesis, NCI-Frederick Cancer Research Facility, MD 21701. Y1 - 1987 PY - 1987 DA - 1987 SP - 97 EP - 116 VL - 10 IS - 1 SN - 0893-6692, 0893-6692 KW - DNA, Bacterial KW - 0 KW - DNA KW - 9007-49-2 KW - Rec A Recombinases KW - EC 2.7.7.- KW - Index Medicus KW - Animals KW - Ultraviolet Rays KW - Fungi -- metabolism KW - Genes, Bacterial KW - Oncogenes -- drug effects KW - Simian virus 40 -- genetics KW - Rec A Recombinases -- physiology KW - Oncogenes -- radiation effects KW - DNA, Bacterial -- drug effects KW - DNA -- drug effects KW - DNA, Bacterial -- radiation effects KW - Bacteria -- genetics KW - Bacteria -- metabolism KW - DNA, Bacterial -- genetics KW - DNA -- genetics KW - Fungi -- genetics KW - DNA -- radiation effects KW - Escherichia coli -- metabolism KW - DNA Repair KW - SOS Response (Genetics) KW - DNA Damage KW - Mammals -- metabolism KW - Escherichia coli -- genetics KW - Mammals -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77885249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Inducible+responses+to+DNA+damage+in+bacteria+and+mammalian+cells.&rft.au=Elespuru%2C+R+K&rft.aulast=Elespuru&rft.aufirst=R&rft.date=1987-01-01&rft.volume=10&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-16 N1 - Date created - 1988-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Structure-activity relations in carcinogenesis by N-nitroso compounds. AN - 77880024; 3319273 AB - For a large number of N-nitroso compounds a comparison of their carcinogenic effects in rats and Syrian golden hamsters has been made. Nitrosamines, which require metabolic activation, and nitrosoalkylamides, which do not, produce quite different tumor responses. There are also large differences in the types of tumor induced in rats and in hamsters. In all the studies doses of the various compounds, equimolar to the extent that was possible, are administered orally. Continuous doses (in drinking water or food) often produce a response different from that after administration of the same compound in pulsed doses (by gavage), even though the same total dose is delivered. Continuous doses of nitrosamines are usually more effective than pulsed doses, but with the nitrosoalkylureas, the reverse is more generally the case. Rat and hamster liver is a common target of many nitrosamines, but rarely of nitrosamides. The most common site of tumor induction in rats by N-nitroso compounds is the esophagus, but the hamster esophagus never responds. The pancreas duct of the hamster is a common target of nitrosamines containing a beta-oxygenated propyl group, but pancreas duct tumors are never seen in rats. Nitrosomethyl-n-alkylamines (with an even numbered carbon chain) induce bladder tumors in rats and hamsters. Many nitrosoalkylureas induce tumors of the nervous system in rats, as well as a great variety of other tumors. In hamsters, nitrosoalkylureas give rise only to tumors of the forestomach and spleen, but no tumors of the nervous system. The similar carcinogenic actions of certain groups of N-nitroso compounds can be related to their generation, directly or by metabolism, of similar simple moieties having certain organs as their target. JF - Cancer metastasis reviews AU - Lijinsky, W AD - BRI-Basic Research Program, NCI-Frederick Cancer Research Facility, MD 21701. Y1 - 1987 PY - 1987 DA - 1987 SP - 301 EP - 356 VL - 6 IS - 3 SN - 0167-7659, 0167-7659 KW - Nitroso Compounds KW - 0 KW - Index Medicus KW - Rats KW - Animals KW - Chemistry KW - Chemical Phenomena KW - Mesocricetus KW - Species Specificity KW - Structure-Activity Relationship KW - Cricetinae KW - Nitroso Compounds -- administration & dosage KW - Neoplasms, Experimental -- chemically induced KW - Nitroso Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77880024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+metastasis+reviews&rft.atitle=Structure-activity+relations+in+carcinogenesis+by+N-nitroso+compounds.&rft.au=Lijinsky%2C+W&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1987-01-01&rft.volume=6&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Cancer+metastasis+reviews&rft.issn=01677659&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-11 N1 - Date created - 1988-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immune response by biological response modifiers. AN - 77879039; 3500779 AB - Several biological response modifiers (BRMs) were demonstrated to increase myelopoiesis and effector cell responses (M phi and natural killer cell activity) in vivo. The increased myelopoiesis was reflected by an increase in bone marrow cellularity and granulocyte-M phi colony-forming cells (GM-CFU-C). The increase in myelopoiesis appeared to be related to a concomitant increase in colony-stimulated factor (CSF) production and secretion by M phi and bone marrow cells. CSF induction by BRMs increased myelopoiesis and counteracted the myelosuppressive and immunosuppressive effects of cyclophosphamide. CSF induced in vivo by BRMs attained high titers and were maintained over a longer period than exogenously injected CSF, which was rapidly cleared from serum. JF - Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc AU - Chirigos, M A AU - Schlick, E AU - Budzynski, W AD - Biological Therapeutics Branch, National Cancer Institute, Frederick, MD 21701. Y1 - 1987 PY - 1987 DA - 1987 SP - 385 EP - 397 VL - 1 SN - 1043-6995, 1043-6995 KW - Adjuvants, Immunologic KW - 0 KW - Aziridines KW - Colony-Stimulating Factors KW - Poly I-C KW - 24939-03-5 KW - Polylysine KW - 25104-18-1 KW - Pyran Copolymer KW - 27100-68-1 KW - Picibanil KW - 39325-01-4 KW - poly ICLC KW - 59789-29-6 KW - Cyclophosphamide KW - 8N3DW7272P KW - Carboxymethylcellulose Sodium KW - K679OBS311 KW - Index Medicus KW - Animals KW - Colony-Stimulating Factors -- biosynthesis KW - Agranulocytosis -- prevention & control KW - Colony-Stimulating Factors -- blood KW - Mice KW - Mice, Inbred BALB C KW - Carboxymethylcellulose Sodium -- pharmacology KW - Poly I-C -- pharmacology KW - Aziridines -- pharmacology KW - Cyclophosphamide -- adverse effects KW - Hematopoietic Stem Cells -- drug effects KW - Picibanil -- pharmacology KW - Polylysine -- pharmacology KW - Pyran Copolymer -- pharmacology KW - Colony-Forming Units Assay KW - Cell Line KW - Macrophages -- immunology KW - Hematopoiesis -- drug effects KW - Granulocytes -- immunology KW - Granulocytes -- drug effects KW - Cytotoxicity, Immunologic -- drug effects KW - Adjuvants, Immunologic -- pharmacology KW - Macrophages -- drug effects KW - Killer Cells, Natural -- immunology KW - Killer Cells, Natural -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77879039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+detection+and+prevention.+Supplement+%3A+official+publication+of+the+International+Society+for+Preventive+Oncology%2C+Inc&rft.atitle=Immune+response+by+biological+response+modifiers.&rft.au=Chirigos%2C+M+A%3BSchlick%2C+E%3BBudzynski%2C+W&rft.aulast=Chirigos&rft.aufirst=M&rft.date=1987-01-01&rft.volume=1&rft.issue=&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Cancer+detection+and+prevention.+Supplement+%3A+official+publication+of+the+International+Society+for+Preventive+Oncology%2C+Inc&rft.issn=10436995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-24 N1 - Date created - 1988-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Valproic acid-induced increase in carnitine acetyltransferase in rat hepatocytes is not due to an induction of peroxisomes. AN - 77874960; 3121863 AB - Valproic acid induced a dose-dependent increase in carnitine acetyltransferase (CAT) activity in rat hepatic mitochondrial fractions isolated by differential centrifugation. An increase in CAT and carnitine palmitoyltransferase (CPT) also occurred in cultured rat hepatocytes in a concentration-and time-dependent fashion. A maximal increase of 8-fold in the activity of CAT and 2-fold in the activity of CPT was induced by 3 mM valproic acid in 72 h. Valproic acid had no effect on cytochrome P-450 levels in cultured rat hepatocytes. Electron-microscopic examination of rat hepatocytes showed that there was no increase in the number of peroxisomes but there was a marked proliferation of mitochondria in parallel with an increase in glutathione level and succinic dehydrogenase in the liver cells after incubation with valproic acid in vitro. JF - Journal of toxicology and environmental health AU - Singh, Y AU - Liu, G A AU - Krishna, G AD - Section on Drug-Tissue Interaction, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 459 EP - 469 VL - 22 IS - 4 SN - 0098-4108, 0098-4108 KW - Valproic Acid KW - 614OI1Z5WI KW - Succinate Dehydrogenase KW - EC 1.3.99.1 KW - Acetyltransferases KW - EC 2.3.1.- KW - Carnitine O-Acetyltransferase KW - EC 2.3.1.7 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Cells, Cultured KW - Kinetics KW - Glutathione -- metabolism KW - Enzyme Induction KW - Microscopy, Electron KW - Succinate Dehydrogenase -- metabolism KW - Male KW - Microbodies -- enzymology KW - Liver -- pathology KW - Liver -- enzymology KW - Carnitine O-Acetyltransferase -- biosynthesis KW - Valproic Acid -- toxicity KW - Liver -- drug effects KW - Acetyltransferases -- biosynthesis KW - Microbodies -- ultrastructure KW - Microbodies -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77874960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health&rft.atitle=Valproic+acid-induced+increase+in+carnitine+acetyltransferase+in+rat+hepatocytes+is+not+due+to+an+induction+of+peroxisomes.&rft.au=Singh%2C+Y%3BLiu%2C+G+A%3BKrishna%2C+G&rft.aulast=Singh&rft.aufirst=Y&rft.date=1987-01-01&rft.volume=22&rft.issue=4&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health&rft.issn=00984108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-23 N1 - Date created - 1988-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Diabetes insipidus with renal resistance to vasopressin in the desoxycorticosterone-treated dog: a possible role for prostaglandins. AN - 77859194; 3479817 AB - We examined the release of vasopressin and the renal response to exogenous vasopressin before and during desoxycorticosterone acetate (DOCA) administration in the dog. As treatment with DOCA produced potassium loss, urine volume increased, urinary osmolality decreased, and urinary PGE2 tended to increase. The increase in urine volume was accompanied by increases in serum sodium, in plasma osmolality and in plasma arginine vasopressin. The threshold for vasopressin release measured during polyuria was higher than control but the rate of vasopressin release was unchanged. The DOCA-induced polyuria was not affected by treatment with vasopressin which further increased plasma vasopressin. Treatment with indomethacin which corrected the increase in urinary PGE2 excretion but not the hypokalemia, restored the renal responsiveness to vasopressin, decreased the secretion of vasopressin, and corrected the polyuria and the hypernatremia. These findings suggest that DOCA-induced polyuria is attributable to a decrease in renal responsiveness to vasopressin which may be mediated in part by an increase in the renal synthesis of prostaglandins. JF - Renal physiology AU - Gullner, H G AU - West, D AU - Gill, J R AU - Robertson, G L AD - Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, Bethesda, Md. Y1 - 1987 PY - 1987 DA - 1987 SP - 40 EP - 46 VL - 10 IS - 1 SN - 0378-5858, 0378-5858 KW - Prostaglandins E KW - 0 KW - Vasopressins KW - 11000-17-2 KW - Desoxycorticosterone KW - 40GP35YQ49 KW - Dinoprostone KW - K7Q1JQR04M KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Animals KW - Potassium -- blood KW - Dogs KW - Body Water -- metabolism KW - Female KW - Vasopressins -- secretion KW - Polyuria -- urine KW - Polyuria -- chemically induced KW - Diabetes Insipidus -- urine KW - Vasopressins -- blood KW - Diabetes Insipidus -- physiopathology KW - Prostaglandins E -- urine KW - Diabetes Insipidus -- chemically induced KW - Polyuria -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77859194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Renal+physiology&rft.atitle=Diabetes+insipidus+with+renal+resistance+to+vasopressin+in+the+desoxycorticosterone-treated+dog%3A+a+possible+role+for+prostaglandins.&rft.au=Gullner%2C+H+G%3BWest%2C+D%3BGill%2C+J+R%3BRobertson%2C+G+L&rft.aulast=Gullner&rft.aufirst=H&rft.date=1987-01-01&rft.volume=10&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Renal+physiology&rft.issn=03785858&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-11 N1 - Date created - 1988-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cell regulatory and immunorestorative activity of picibanil (OK432). AN - 77855594; 3480058 AB - Picibanil (OK432), a pharmaceutical preparation of a low virulent Su strain of Streptococcus pyogenes, possesses cell regulatory activity particularly in its ability to augment natural killer (NK) cell activity and to activate macrophages to exert a tumoricidal effect both in vitro and in vivo. It is effective in retarding and/or inhibiting the growth of three different tumors: MBL-2 lymphoma, M109 alveolar adenocarcinoma, and B16 melanoma. The antitumor effect is mediated through regulation of NK cells and macrophages, possibly by its ability to stimulate the production and secretion of interferon and interleukin 1 and 2. It is a very effective adjuvant for tumor cell vaccines that elicit cytotoxic T-cell responses. Following cytoreductive chemotherapy (Cytoxan) Picibanil treatment leads to an earlier reconstitution of both bone marrow cellularity and differentiation to granulocyte-macrophage colonies. JF - Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc AU - Chirigos, M A AU - Saito, T AU - Talmadge, J E AU - Budzynski, W AU - Gruys, E AD - Immunopharmacology Section, National Cancer Institute, Frederick, MD 21701. Y1 - 1987 PY - 1987 DA - 1987 SP - 317 EP - 328 VL - 1 SN - 1043-6995, 1043-6995 KW - Biological Products KW - 0 KW - Poly I-C KW - 24939-03-5 KW - Polylysine KW - 25104-18-1 KW - Picibanil KW - 39325-01-4 KW - poly ICL KW - 63779-59-9 KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Bone Marrow Cells KW - Animals KW - Polylysine -- pharmacology KW - In Vitro Techniques KW - Mice, Inbred C57BL KW - Mice KW - Mice, Inbred BALB C KW - Colony-Forming Units Assay KW - Melanoma, Experimental -- therapy KW - Male KW - Cell Line KW - Poly I-C -- pharmacology KW - Cyclophosphamide -- pharmacology KW - Picibanil -- pharmacology KW - Hematopoietic Stem Cells -- cytology KW - Cytotoxicity, Immunologic -- drug effects KW - Biological Products -- pharmacology KW - Picibanil -- therapeutic use KW - Killer Cells, Natural -- immunology KW - Killer Cells, Natural -- drug effects KW - Macrophage Activation -- drug effects KW - Hematopoietic Stem Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77855594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+detection+and+prevention.+Supplement+%3A+official+publication+of+the+International+Society+for+Preventive+Oncology%2C+Inc&rft.atitle=Cell+regulatory+and+immunorestorative+activity+of+picibanil+%28OK432%29.&rft.au=Chirigos%2C+M+A%3BSaito%2C+T%3BTalmadge%2C+J+E%3BBudzynski%2C+W%3BGruys%2C+E&rft.aulast=Chirigos&rft.aufirst=M&rft.date=1987-01-01&rft.volume=1&rft.issue=&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Cancer+detection+and+prevention.+Supplement+%3A+official+publication+of+the+International+Society+for+Preventive+Oncology%2C+Inc&rft.issn=10436995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-24 N1 - Date created - 1988-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Potential oncogenic hazards posed by oncogene encoded proteins. AN - 77855311; 3319740 AB - The theoretical risk from oncogene encoded proteins is limited to growth factors, which may be secreted by cells in which biologically derived products might be manufactured. Because these peptides do not replicate, their effect is finite. In addition, their effects are reversible. Growth factors do not ordinarily appear to be oncogenic. Even under circumstances in which they contribute to oncogenicity, repeated administration of high concentrations of growth factors (several micrograms per kilogram) would appear to be required for them to serve as co-factors in the carcinogenic process, and the resulting tumors appear to remain dependent upon the continued presence of the growth factor for continued tumor growth. JF - Developments in biological standardization AU - Lowy, D R AD - Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1987 PY - 1987 DA - 1987 SP - 63 EP - 67 VL - 68 SN - 0301-5149, 0301-5149 KW - Growth Substances KW - 0 KW - Proto-Oncogene Proteins KW - Index Medicus KW - Risk KW - Growth Substances -- genetics KW - Animals KW - Genetic Engineering KW - Oncogenes KW - Proto-Oncogenes KW - Proto-Oncogene Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77855311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developments+in+biological+standardization&rft.atitle=Potential+oncogenic+hazards+posed+by+oncogene+encoded+proteins.&rft.au=Lowy%2C+D+R&rft.aulast=Lowy&rft.aufirst=D&rft.date=1987-01-01&rft.volume=68&rft.issue=&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Developments+in+biological+standardization&rft.issn=03015149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-29 N1 - Date created - 1988-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of regulations on occupational carcinogens in several industrialized countries. AN - 77851715; 3687947 AB - Regulations controlling the manufacture and use of carcinogens in the industrial setting of various countries are examined. In addition, the occupational exposure limits (OEL) of chemicals known or suspected to be carcinogenic in humans are listed, and criteria for the establishment of OELs are discussed. It is also stressed that control measures should not be confined to a few developed countries, and it is hoped that attracting attention to their unevenness will contribute to the implementation of a more efficient primary prevention of cancer. JF - American journal of industrial medicine AU - Carnevale, F AU - Montesano, R AU - Partensky, C AU - Tomatis, L AD - Servizio di Prevenzione Igiene e Sicurezza nei Luoghi di Lavoro, Florence, Italy. Y1 - 1987 PY - 1987 DA - 1987 SP - 453 EP - 473 VL - 12 IS - 5 SN - 0271-3586, 0271-3586 KW - Carcinogens KW - 0 KW - Index Medicus KW - Maximum Allowable Concentration KW - Humans KW - Environmental Exposure KW - Occupational Diseases -- prevention & control KW - Neoplasms -- chemically induced KW - Cross-Cultural Comparison KW - Neoplasms -- prevention & control KW - Occupational Diseases -- chemically induced KW - Legislation as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77851715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Comparison+of+regulations+on+occupational+carcinogens+in+several+industrialized+countries.&rft.au=Carnevale%2C+F%3BMontesano%2C+R%3BPartensky%2C+C%3BTomatis%2C+L&rft.aulast=Carnevale&rft.aufirst=F&rft.date=1987-01-01&rft.volume=12&rft.issue=5&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-06 N1 - Date created - 1988-01-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - N-nitroso-N-methylaniline: possible mode of DNA modification. AN - 77829067; 3679445 JF - IARC scientific publications AU - Koepke, S R AU - Kroeger-Koepke, M B AU - Michejda, C J AD - LBI-Basic Research Program, NCI-Frederick Cancer Research Facility, MD 21701. Y1 - 1987 PY - 1987 DA - 1987 SP - 68 EP - 70 IS - 84 SN - 0300-5038, 0300-5038 KW - Nitrosamines KW - 0 KW - DNA KW - 9007-49-2 KW - N-methyl-N-nitrosoaniline KW - 9SM68I29WQ KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Liver -- drug effects KW - Liver -- metabolism KW - Nucleic Acid Conformation -- drug effects KW - Methylation KW - Male KW - Nitrosamines -- toxicity KW - Nitrosamines -- metabolism KW - DNA Damage -- drug effects KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77829067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=N-nitroso-N-methylaniline%3A+possible+mode+of+DNA+modification.&rft.au=Koepke%2C+S+R%3BKroeger-Koepke%2C+M+B%3BMichejda%2C+C+J&rft.aulast=Koepke&rft.aufirst=S&rft.date=1987-01-01&rft.volume=&rft.issue=84&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-12 N1 - Date created - 1988-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recent findings on the metabolism of beta-hydroxyalkylnitrosamines. AN - 77806031; 3316003 AB - beta-Hydroxynitrosamines appear to be refractory to alpha-oxidation, the common pathway of metabolism of simple dialkylnitrosamines. Some years ago, we postulated that nitrosamines bearing a hydroxyl in the beta position may be activated to alkylating agents by metabolic transformation to sulfate conjugates. Recent evidence has provided support for this hypothesis. A sulfate ester of N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (NHPOPA) has been found in the urine of hamsters treated with the nitrosamine. It has also been found that inhibition of sulfotransferases inhibited the development of DNA single-strand breaks in livers of rats treated with several beta-hydroxy-nitrosamines. Alkylation of rat liver DNA in vivo by N-nitroso(2-hydroxyethyl)methylamine (NHEMA) favoured methylation over 2-hydroxyethylation by a factor of 10. The methylation reaction was inhibited by sulfotransferase inhibitors. Thus, sulfation appears to be an important pathway for activation of beta-hydroxy-nitrosamines. There are, however, other pathways, such as the oxidation of the beta-hydroxyl group to a carbonyl, which may also result in the formation of electrophilic species capable of modifying cellular macromolecules. JF - IARC scientific publications AU - Michejda, C J AU - Koepke, S R AU - Kroeger-Koepke, M B AU - Bosan, W AD - LBI-Basic Research Program, NCI-Frederick Cancer Research Facility, MD 21701. Y1 - 1987 PY - 1987 DA - 1987 SP - 77 EP - 82 IS - 84 SN - 0300-5038, 0300-5038 KW - Nitrosamines KW - 0 KW - Sulfates KW - N-nitrosodiethanolamine KW - 30YI1289VY KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - diisopropanolnitrosamine KW - 4J072HB2ND KW - Index Medicus KW - Animals KW - Diethylnitrosamine -- metabolism KW - Alkylation KW - Hydroxylation KW - Structure-Activity Relationship KW - Sulfates -- metabolism KW - Diethylnitrosamine -- analogs & derivatives KW - Oxidation-Reduction KW - Rats KW - Rats, Inbred F344 KW - Methylation KW - Female KW - Male KW - Nitrosamines -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77806031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=Recent+findings+on+the+metabolism+of+beta-hydroxyalkylnitrosamines.&rft.au=Michejda%2C+C+J%3BKoepke%2C+S+R%3BKroeger-Koepke%2C+M+B%3BBosan%2C+W&rft.aulast=Michejda&rft.aufirst=C&rft.date=1987-01-01&rft.volume=&rft.issue=84&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-12 N1 - Date created - 1988-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolism and cellular interactions of N-nitrosodiethanolamine. AN - 77804177; 2445676 AB - N-Nitrosodiethanolamine (NDELA) labelled with 14C at the alpha carbon was administered by gavage to adult male Fischer 344 rats at various doses ranging from 0.6 to 100 mg per rat. The proportion of the dose excreted as 14CO2 was small, ranging from 0.27% at the lowest dose to 0.83% at the highest in 24 h. At all doses, approximately 95% of the dose of radioactivity (most of which was NDELA) appeared in the urine within 24 h, but the proportion of metabolites increased from 7% to 14% from the lowest to the highest dose. The specific activity of the nucleic acids isolated from the liver of rats given 100 mg and 100 microCi of NDELA was very low and was the same at 6 h and 24 h after treatment (70 dpm/mg DNA, 92-95 dpm/mg RNA). N7-(2-Hydroxyethyl)guanine and O6-(2-hydroxyethyl)-guanine were tentatively identified in the hydrolysates of the nucleic acids, comprising 10% and 4%, respectively, of the DNA radioactivity; there was no difference between the amounts found 6 h and 24 h after NDELA treatment. In addition to NDELA, four components were separated from rat urine, and two were identified. One is the glucuronide of NDELA, the other is N-nitroso-N-(2-hydroxyethyl)carboxymethylamine. Neither nitroso-2-hydroxymorpholine nor a sulfate of NDELA was detected. JF - IARC scientific publications AU - Farrelly, J G AU - Thomas, B J AU - Lijinsky, W AD - NCI-Frederick Cancer Research Facility, LBI-Basic Research Program, MD 21701. Y1 - 1987 PY - 1987 DA - 1987 SP - 87 EP - 90 IS - 84 SN - 0300-5038, 0300-5038 KW - N-nitrosodiethanolamine KW - 30YI1289VY KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - RNA KW - 63231-63-0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - RNA -- metabolism KW - DNA -- metabolism KW - Metabolic Clearance Rate KW - Liver -- metabolism KW - Male KW - Diethylnitrosamine -- analogs & derivatives KW - Diethylnitrosamine -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77804177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=Metabolism+and+cellular+interactions+of+N-nitrosodiethanolamine.&rft.au=Farrelly%2C+J+G%3BThomas%2C+B+J%3BLijinsky%2C+W&rft.aulast=Farrelly&rft.aufirst=J&rft.date=1987-01-01&rft.volume=&rft.issue=84&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-12 N1 - Date created - 1988-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Studies By the National Toxicology Program On Di(2-Ethylhexyl)Phthalate AN - 760215197; 13641398 AB - In a 2-year feed study previously reported by the National Toxicology Program (NTP), the plasticizer di(2-ethylhexyl)phthalate (DEHP) was found to produce increased incidences of hepatocellular neoplasms in both sexes of Fischer 344 (F344) rats and B6C3F1 mice. Further studies by the NTP on this chemical have investigated its genotoxicity, dermal absorption, reproductive and developmental toxicity, and biochemical mechanism of action. DEHP was not mutagenic in Salmonella typhimurium (strains TA98, TA100, TA1535 or TA1537), in L5178Y mouse lymphoma cells, or in Drosophila melanogaster. DEHP did not induce chromosomal aberrations, but did cause a marginal dose-related increase in sister chromatid exchanges in CHO cells. In a dermal absorption study, DEHP was not absorbed well through the skin of F344 rats. In a fertility assessment study, DEHP was shown to be a reproductive toxicant in both male and female CD-1 mice. The teratogenic potential of DEHP was evaluated in F344 rats and CD-1 mice. In the rat study, there were no significant differences in percent fetuses malformed between control and treatment groups, even at dose levels (1.0, 1.5 and 2.0%) which produced significant maternal and fetal toxicity. In the mouse study, the incidence of fetuses with malformations was significantly increased at dose levels which produced maternal and/or fetal toxicity (0.10 and 0.15%), and at a dose level (0.05%) which did not cause maternal or fetal toxicity. The no-observed effect level for developmental toxicity in mice was 0.025% DEHP. Kinetic data on the rates of formation of H sub(2)O sub(2) by peroxisomal palmitoyl CoA oxidase, and of degradation of H sub(2)O sub(2) by catalase, was used to estimate in vitro steady-state H sub(2)O sub(2) concentrations during peroxisofnal oxidation of palmitoyl CoA. Increases in steady-state H sub( 2)O sub(2) in liver homogenates of rats treated with DEHP, di(2-ethylhexyl)adipate, or nafenopin, a hypolipidemic drug, correlated well with the carcinogenic potential of these cheniicals determined in previous carcinogenicity studies, and are consistent with but not definitive evidence for the involvement of peroxisome proliferation in the hepatocarcinogenesis of these compounds. JF - Toxicology and Industrial Health AU - Melnick, Ronald L AU - Morrissey, Richard E AU - Tomaszewski, Konrad E AD - National Toxicology Program National Institute of Environmental Health Sciences Research Triangle Park, North Carolina Y1 - 1987 PY - 1987 DA - 1987 SP - 99 EP - 118 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 3 IS - 2 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts KW - dermal absorption KW - genotoxicity KW - peroxisomes KW - phthalate KW - reproductive toxicity KW - teratogenicity. KW - Fertility KW - Skin KW - Data processing KW - Toxicants KW - Genotoxicity KW - Plasticizers KW - sister chromatids KW - Salmonella typhimurium KW - Peroxisomes KW - Catalase KW - Fetuses KW - Carcinogenicity KW - Hydrogen peroxide KW - Kinetics KW - Drosophila melanogaster KW - Oxidation KW - Liver KW - Teratogenicity KW - Lymphoma KW - Drugs KW - Chromosome aberrations KW - Sex KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760215197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Studies+By+the+National+Toxicology+Program+On+Di%282-Ethylhexyl%29Phthalate&rft.au=Melnick%2C+Ronald+L%3BMorrissey%2C+Richard+E%3BTomaszewski%2C+Konrad+E&rft.aulast=Melnick&rft.aufirst=Ronald&rft.date=1987-01-01&rft.volume=3&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F074823378700300208 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 23 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Fertility; Data processing; Skin; Toxicants; Genotoxicity; Plasticizers; sister chromatids; Fetuses; Catalase; Peroxisomes; Hydrogen peroxide; Carcinogenicity; Kinetics; Oxidation; Liver; Teratogenicity; Chromosome aberrations; Drugs; Lymphoma; Sex; Drosophila melanogaster; Salmonella typhimurium DO - http://dx.doi.org/10.1177/074823378700300208 ER - TY - JOUR T1 - Coal-forming model of peat flat and paleogeographic setting of epeiric sea barrier-island system in Carboniferous coal measures of North China AN - 50595003; 1991-020813 JF - Compte Rendu - Congres International de Stratigraphie et de Geologie du Carbonifere = International Congress on Carboniferous Stratigraphy and Geology. AU - Liu, Huanjie AU - Zhang, Yujin AU - Wang, Hongwei AU - Mao, Shanjun AU - Anonymous Y1 - 1987 PY - 1987 DA - 1987 SP - 256 PB - [publisher varies], [location varies] VL - 11 SN - 0379-6825, 0379-6825 KW - Far East KW - organic residues KW - carbonate platforms KW - Paleozoic KW - Northern China KW - sedimentation KW - Carboniferous KW - paleogeography KW - models KW - peat KW - sedimentary rocks KW - coal KW - sedimentary petrology KW - sediments KW - Asia KW - coastal sedimentation KW - China KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50595003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Compte+Rendu+-+Congres+International+de+Stratigraphie+et+de+Geologie+du+Carbonifere+%3D+International+Congress+on+Carboniferous+Stratigraphy+and+Geology.&rft.atitle=Coal-forming+model+of+peat+flat+and+paleogeographic+setting+of+epeiric+sea+barrier-island+system+in+Carboniferous+coal+measures+of+North+China&rft.au=Liu%2C+Huanjie%3BZhang%2C+Yujin%3BWang%2C+Hongwei%3BMao%2C+Shanjun%3BAnonymous&rft.aulast=Liu&rft.aufirst=Huanjie&rft.date=1987-01-01&rft.volume=11&rft.issue=&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Compte+Rendu+-+Congres+International+de+Stratigraphie+et+de+Geologie+du+Carbonifere+%3D+International+Congress+on+Carboniferous+Stratigraphy+and+Geology.&rft.issn=03796825&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 11th international congress of Carboniferous stratigraphy and geology N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1991-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - CSGCAG N1 - SubjectsTermNotLitGenreText - Asia; carbonate platforms; Carboniferous; China; coal; coastal sedimentation; Far East; models; Northern China; organic residues; paleogeography; Paleozoic; peat; sedimentary petrology; sedimentary rocks; sedimentation; sediments ER - TY - JOUR T1 - The Multiple Causes of Multiple Sclerosis: The Importance of Age of Infections in Childhood AN - 21205806; 11647807 AB - The geographic distribution of multiple sclerosis (MS) may relate to the age of inital exposure and degree of sensitization to common viruses or bacteria which have proteins with epitopes (antigenic determinants) which are homologous with potentially encephalitogenic peptides in central myelin proteins, such as basic protein and proteolipid protein. Comparable homologies may exist for the as-yet-undefined nonencephalitogenic myelin antigen(s) which evoke demyelinating factors (probably complement-fixing antibodies). Many of these homologous epitopes occur in microorganisms that also possess adjuvant activity for evoking not only the sensitized T-cells but also the antibodies that cross-react with the target antigens in central myelin. If sufficient sensitization to myelin basic protein or proteolipid protein occurs, especially in infections of young adults, the individual develops acute disseminated encephalomyelitis, exactly comparable to ordinary acute experimental allergic encephalomyelitis (EAE). If very young children are infected, however, practically complete resistance develops, and neither acute disseminated encephalomyelitis nor MS follows. In between these two extremes, especially in slightly older children in whom insufficient sensitization occurs to induce acute disseminated encephalomyelitis, the individual may become resistant to acute disseminated encephalomyelitis, but susceptible to chronic relapsing or progressive disseminated encephalomyelitis, otherwise generally recognized as MS. This is exactly comparable to a recently described variant of chronic EAE in which demyelinating antibodies and large subpial plaques of demyelination occur. The similarity of this form of chronic EAE or chronic disseminated encephalomyelitis to one form of MS is emphasized. (J Child Neurol 1987; 2:313-321). JF - Journal of Child Neurology AU - Alvord, Ellsworth C AU - Jahnke, Ulrike AU - Fischer, Edmond H AU - Kies, Marian W AU - Driscoll, Bernard F AU - Compston, DAlastair S AD - Departments of Pathology and Biochemistry, University of Washington School of Medicine, Seattle, WA, Section of Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD, Department of Neurology, University of Wales College of Medicine, Cardiff, UK Y1 - 1987 PY - 1987 DA - 1987 SP - 313 EP - 320 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 2 IS - 4 SN - 0883-0738, 0883-0738 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts; Immunology Abstracts KW - Geographical distribution KW - Age KW - Myelin KW - Multiple sclerosis KW - Adjuvants KW - Demyelination KW - Children KW - Proteolipid protein KW - Antibodies KW - Homology KW - Antigenic determinants KW - Microorganisms KW - Lymphocytes T KW - Plaques KW - Experimental allergic encephalomyelitis KW - Epitopes KW - Myelin basic protein KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - F 06930:Autoimmunity KW - N3 11027:Neurology & neuropathology KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21205806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Neurology&rft.atitle=The+Multiple+Causes+of+Multiple+Sclerosis%3A+The+Importance+of+Age+of+Infections+in+Childhood&rft.au=Alvord%2C+Ellsworth+C%3BJahnke%2C+Ulrike%3BFischer%2C+Edmond+H%3BKies%2C+Marian+W%3BDriscoll%2C+Bernard+F%3BCompston%2C+DAlastair+S&rft.aulast=Alvord&rft.aufirst=Ellsworth&rft.date=1987-01-01&rft.volume=2&rft.issue=4&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Neurology&rft.issn=08830738&rft_id=info:doi/10.1177%2F088307388700200418 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; Geographical distribution; Myelin; Multiple sclerosis; Demyelination; Adjuvants; Children; Proteolipid protein; Antibodies; Homology; Antigenic determinants; Lymphocytes T; Microorganisms; Plaques; Experimental allergic encephalomyelitis; Myelin basic protein; Epitopes DO - http://dx.doi.org/10.1177/088307388700200418 ER - TY - JOUR T1 - Combined Lithium and Electroconvulsive Therapy: Pharmacokinetic and Pharmacodynamic Interactions. AN - 1859369352; 11940888 AB - The combined use of lithium and electroconvulsive therapy (ECT) is currently contraindicated, due to reports of associated neurotoxicity and poor outcome. Only limited data are available to explain any pharmacological basis for an adverse interaction between the two treatments. ECT does not alter lithium distribution or kinetics. Possible drug-drug interactions between lithium and ECT premedication have been subjected to little systematic study. Despite a body of preclinical work implicating the cholinergic system in the mechanism of action of both lithium and ECT, no interaction between lithium and pre-ECT anticholinergic medication has been reported. Potentiation of barbiturate anesthetics and neuromuscular blocking agents, including succinylcholine, by lithium has been noted in the anesthesiology literature, but reports of such interaction are lacking in the context of ECT administration. Thus, no demonstrable pharmacokinetic or drug-drug interaction factors preclude combined prescription of lithium and ECT. JF - Convulsive therapy AU - Rudorfer, Matthew V. AU - Linnoila, Markku AU - Potter, William Z. AD - Section on Clinical Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland, USA. Y1 - 1987 PY - 1987 DA - 1987 SP - 40 EP - 45 VL - 3 IS - 1 SN - 0749-8055, 0749-8055 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859369352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Convulsive+therapy&rft.atitle=Combined+Lithium+and+Electroconvulsive+Therapy%3A+Pharmacokinetic+and+Pharmacodynamic+Interactions.&rft.au=Rudorfer%2C+Matthew+V.%3BLinnoila%2C+Markku%3BPotter%2C+William+Z.&rft.aulast=Rudorfer&rft.aufirst=Matthew&rft.date=1987-01-01&rft.volume=3&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Convulsive+therapy&rft.issn=07498055&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2002-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - ECT and Neurological Disorders. AN - 1859368855; 11940905 AB - Clinicians become concerned when ECT is contemplated in an individual with a neurological disorder. In this review, the authors summarize the reports on the use of ECT in the presence of neurological disease. Because blood pressure, cerebral blood flow, and intracranial pressure rise with ECT, space-occupying lesions with increased intracranial pressure, cerebral aneurysm, recent head trauma, or active CNS infection pose special concerns for ECT treatment. In this review, we conclude that epilepsy and states with lowered seizure threshold may predispose to prolonged seizures. A history of head injury or stroke probably does not increase risk. Toxic/metabolic disorders are not contraindications to ECT, although correction of the underlying imbalance is a first priority. Extrapyramidal, demyelinating, and neuromuscular disorders pose little increased risk. Indeed, in Parkinson's Disease, ECT may be beneficial for the motor symptoms. As a general rule, it seems advisable to treat the underlying disorder prior to beginning ECT. JF - Convulsive therapy AU - Hsiao, John K. AU - Messenheimer, John A. AU - Evans, Dwight L. AD - Department of Psychiatry, University of North Carolina, School of Medicine, Chapel Hill, North Carolina; and Section on Clinical Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland, USA. Y1 - 1987 PY - 1987 DA - 1987 SP - 121 EP - 136 VL - 3 IS - 2 SN - 0749-8055, 0749-8055 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859368855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Convulsive+therapy&rft.atitle=ECT+and+Neurological+Disorders.&rft.au=Hsiao%2C+John+K.%3BMessenheimer%2C+John+A.%3BEvans%2C+Dwight+L.&rft.aulast=Hsiao&rft.aufirst=John&rft.date=1987-01-01&rft.volume=3&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Convulsive+therapy&rft.issn=07498055&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2002-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Solid phase extraction of urinary polypeptide growth factors using methyl bonded silica in free suspension. AN - 15612514; 2262419 AB - Methyl bonded silica effectively concentrates EGF, TFG- alpha and TGF- beta from urine. Further chromatography on sizing gel, carboxymethyl cellulose, and HPLC provided complete separation of TGF- alpha from the much more abundant but bioactively similar EGF. JF - Journal of Liquid Chromatography AU - Hudgins, W R AU - Stromberg, K AD - NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 3329 EP - 3346 VL - 10 IS - 15 SN - 0148-3919, 0148-3919 KW - extraction KW - growth factors KW - high-performance liquid chromatography KW - silica KW - urine KW - use KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15612514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Liquid+Chromatography&rft.atitle=Solid+phase+extraction+of+urinary+polypeptide+growth+factors+using+methyl+bonded+silica+in+free+suspension.&rft.au=Hudgins%2C+W+R%3BStromberg%2C+K&rft.aulast=Hudgins&rft.aufirst=W&rft.date=1987-01-01&rft.volume=10&rft.issue=15&rft.spage=3329&rft.isbn=&rft.btitle=&rft.title=Journal+of+Liquid+Chromatography&rft.issn=01483919&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - The mechanism for the inhibition of prostaglandin H synthase-catalyzed xenobiotic oxidation by methimazole: Reaction with free radical oxidation products. AN - 15268957; 2031772 AB - Methimazole, an irreversible, mechanism-based (suicide substrate) inhibitor of thyroid peroxidase and lactoperoxidase, also inhibits the oxidation of xenobiotics by prostaglandin hydroperoxidase. The data indicate that methimazole does not inhibit xenobiotic oxidations catalyzed by prostaglandin H synthase and horseradish peroxidase through direct interaction with the enzyme, but rather inhibits accumulation of oxidation products via reduction of a free radical-derived metabolite(s). JF - Journal of Biological Chemistry AU - Petry, T W AU - Eling, TE AD - Lab. Mol. Biophys., NIH, NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 1412 EP - 1418 VL - 262 IS - 29 SN - 0021-9258, 0021-9258 KW - inhibition KW - mechanisms KW - methimazole KW - oxidation KW - prostaglandin hydroperoxidase KW - xenobiotics KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15268957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=The+mechanism+for+the+inhibition+of+prostaglandin+H+synthase-catalyzed+xenobiotic+oxidation+by+methimazole%3A+Reaction+with+free+radical+oxidation+products.&rft.au=Petry%2C+T+W%3BEling%2C+TE&rft.aulast=Petry&rft.aufirst=T&rft.date=1987-01-01&rft.volume=262&rft.issue=29&rft.spage=1412&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Sex-differences in ethanol sensitivity and alcohol and aldehyde dehydrogenase activities in the Syrian hamster. AN - 15134837; 1923312 AB - Because male Syrian hamsters demonstrate greater preference for ethanol than female hamsters, the authors compared them with regard to ethanol sensitivity and hepatic alcohol and aldehyde dehydrogenase activities. Male hamsters were slower to recover righting response and had lower blood alcohol levels upon recovery than did females. Hepatic alcohol dehydrogenase activity was approximately twice as high in females as males, but gender differences were not found for either cytosolic or non-cytosolic aldehyde dehydrogenase activities. The results suggest that the reduced ethanol sensitivity of female hamsters is due to more rapid metabolism. However, the finding that female hamsters have higher blood alcohol concentrations upon recovery also suggests the possibility of reduced CNS sensitivity. JF - Alcohol and Drug Research AU - Moss, H B AU - Salin-Pascual, R J AU - Rathnagiri, P AU - Goldman, D AU - Tamarkin, L AD - Lab. Clin. Stud., DICBR, NIAAA, Bethesda, MD 20205, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 301 EP - 307 VL - 7 IS - 4 KW - ethanol KW - sensitivity KW - alcohol dehydrogenase KW - aldehyde dehydrogenase KW - hamsters KW - Toxicology Abstracts KW - sex differences KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15134837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+Drug+Research&rft.atitle=Sex-differences+in+ethanol+sensitivity+and+alcohol+and+aldehyde+dehydrogenase+activities+in+the+Syrian+hamster.&rft.au=Moss%2C+H+B%3BSalin-Pascual%2C+R+J%3BRathnagiri%2C+P%3BGoldman%2C+D%3BTamarkin%2C+L&rft.aulast=Moss&rft.aufirst=H&rft.date=1987-01-01&rft.volume=7&rft.issue=4&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+Drug+Research&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - sex differences ER - TY - CONF T1 - The rat populations of NIMH: Density, reproduction, and the neocortex. AN - 15078555; 1883442 AB - Investigations of the effects of crowding on social behavior has long been a major focus of the research on rodent populations conducted in the laboratory of John B. Calhoun, at the National Institute of Mental Health. In these studies, rats living under crowded conditions exhibited many behavioral abnormalities, including poor parental behavior, and excessive aggression. Results have been interpreted as showing that rats are sensitive to differences in population density even at relatively low absolute population sizes, and that increased population density interferes with the capacity of the neocortex to cope with environment complexity. JF - American Zoologist AU - Hill, J L Y1 - 1987 PY - 1987 DA - 1987 SP - 839 EP - 851 VL - 27 IS - 3 KW - damage KW - effects on KW - Animal Behavior Abstracts; Ecology Abstracts KW - population density KW - behavior KW - brain KW - Rattus norvegicus KW - D 04672:Mammals KW - Y 25507:Mammals (excluding primates) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15078555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Zoologist&rft.atitle=The+rat+populations+of+NIMH%3A+Density%2C+reproduction%2C+and+the+neocortex.&rft.au=Hill%2C+J+L&rft.aulast=Hill&rft.aufirst=J&rft.date=1987-01-01&rft.volume=27&rft.issue=3&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=American+Zoologist&rft.issn=00031569&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Partial purification and characterization of an insulin-like material from spinach and Lemna gibba G3. AN - 14963465; 1790863 AB - The authors describe here material in two plants, spinach and Lemma gibba G3, that is very similar to mammalian insulin, yet distinctive. The role of this insulin-like material in plants is unknown but its existence is consistent with an early evolutionary origin of the insulin messenger peptide family. JF - Journal of Biological Chemistry AU - Collier, E AU - Watkinson, A AU - Cleland, C F AU - Roth, J AD - Diabetes Branch, NIDDK, Build. 10, Rm. 8N-250, NIH, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 6238 EP - 6247 VL - 262 IS - 13 SN - 0021-9258, 0021-9258 KW - Lemma gibba KW - Spinacea oleracea KW - insulin KW - like KW - proteins KW - purification KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14963465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Partial+purification+and+characterization+of+an+insulin-like+material+from+spinach+and+Lemna+gibba+G3.&rft.au=Collier%2C+E%3BWatkinson%2C+A%3BCleland%2C+C+F%3BRoth%2C+J&rft.aulast=Collier&rft.aufirst=E&rft.date=1987-01-01&rft.volume=262&rft.issue=13&rft.spage=6238&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Studies of antibody and complement function in host defense against bacterial infection. AN - 14958972; 1776936 JF - Immunology Letters AU - Joiner, KA AU - Fries, L F AU - Frank, M M AD - NIAID/Natl. Inst. Health, 9000 Rockville Pike, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 197 EP - 202 VL - 14 IS - 3 SN - 0165-2478, 0165-2478 KW - infection KW - role KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - complement KW - antibodies KW - immunity KW - gram-negative bacteria KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14958972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology+Letters&rft.atitle=Studies+of+antibody+and+complement+function+in+host+defense+against+bacterial+infection.&rft.au=Joiner%2C+KA%3BFries%2C+L+F%3BFrank%2C+M+M&rft.aulast=Joiner&rft.aufirst=KA&rft.date=1987-01-01&rft.volume=14&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Immunology+Letters&rft.issn=01652478&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - gram-negative bacteria; immunity; antibodies; complement ER - TY - JOUR T1 - Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl and 3-methylcholanthrene. AN - 14950598; 1776291 AB - Rat liver cytochrome P-450 2c (P-450 2c) is a constitutive, male-specific enzyme that oxidatively metabolizes both steroid hormones and liphophilic foreign compounds. Exposure of adult male rats to certain xenobiotics can lead to a decrease in the expression of hepatic P-450 2c. The present studies were undertaken to examine the mechanism of this decrease. Treatment of adult male rats with 3-methylcholanthrene (3-MC) or 3,4,5,3',4',5'-hexachlorobiphenyl (HCB) decreased hepatic content of P-450 2c and its associated steroid hormone 2 alpha -and 16 alpha -hydroxylase activities. Decreases in hepatic content of P-450 2c mRNA (determined by electrophoretic analysis of immunoprecipitated translational products) fully account for the effects of 3-MC and HCB on P-450 2c. JF - Molecular Pharmacology AU - Yeowell, H N AU - Waxman, D J AU - Wadhera, A AU - Goldstein, JA AD - NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 340 EP - 347 VL - 32 IS - 3 SN - 0026-895X, 0026-895X KW - suppression KW - 3,4,5,3',4',5'-hexachlorobiphenyl KW - 3-methylcholanthrene KW - cytochrome P450 2c KW - rats KW - Toxicology Abstracts KW - liver KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14950598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmacology&rft.atitle=Suppression+of+the+constitutive%2C+male-specific+rat+hepatic+cytochrome+P-450+2c+and+its+mRNA+by+3%2C4%2C5%2C3%27%2C4%27%2C5%27-hexachlorobiphenyl+and+3-methylcholanthrene.&rft.au=Yeowell%2C+H+N%3BWaxman%2C+D+J%3BWadhera%2C+A%3BGoldstein%2C+JA&rft.aulast=Yeowell&rft.aufirst=H&rft.date=1987-01-01&rft.volume=32&rft.issue=3&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - liver ER - TY - JOUR T1 - ADP, chloride ion, and metal ion binding to bovine brain glutamine synthetase. AN - 14938331; 1772495 AB - The binding of divalent cations and nucleotide to bovine brain glutamine synthetase and their effects on the activity of the enzyme were investigated. The method of continuous variation applied to the Mn super(2+)-supported reaction indicated that all subunits of the purified enzyme express activity when 1.0 equiv of ADP is bound per subunit. JF - Biochemistry (Washington) AU - Maurizi, M R AU - Pinkofsky, H B AU - Ginsburg, A AD - NHLBI/NIH, Build. 3, Rm. 208, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 5023 EP - 5031 VL - 26 IS - 16 SN - 0006-2960, 0006-2960 KW - ADP KW - binding KW - brain KW - cattle KW - chloride KW - glutamate-ammonia ligase KW - ions KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - N3 11070:Neurochemistry and cellular biology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14938331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=ADP%2C+chloride+ion%2C+and+metal+ion+binding+to+bovine+brain+glutamine+synthetase.&rft.au=Maurizi%2C+M+R%3BPinkofsky%2C+H+B%3BGinsburg%2C+A&rft.aulast=Maurizi&rft.aufirst=M&rft.date=1987-01-01&rft.volume=26&rft.issue=16&rft.spage=5023&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - brain ER - TY - JOUR T1 - The enzymatic oxidation of Desferal to a nitroxide free radical. AN - 14926911; 1759849 AB - Desferrioxamine mesylate (Desferal), a transition metal ion chelator, has been used to inhibit the in vitro redox cycling of transition metal ions. ESR spectroscopy was utilized to detect and identify Desferal's one-electron oxidation product. The authors demonstrate that a horseradish peroxidase/H sub(2)O sub(3) system, a xanthine oxidase/hypoxanthine system, and a hydroxyl radical-generating system are all capable of oxidizing Desferal to a nitroxide free radical. The same 9-line ESR spectrum (g = 2.0065, a super(N) = 7.85 G, a super(H)(2) = 6.35 G) was detected in all of the above systems. They therefore, stress that care must be taken when using Desferal as a transition metal ion chelator to keep its concentration low enough to minimize these reactions, or to use a different metal ion chelator. JF - FEBS Letters AU - Morehouse, K M AU - Flitter, W D AU - Mason, R P AD - 10-02, NIEHS/LMB, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 246 EP - 250 VL - 222 IS - 2 SN - 0014-5793, 0014-5793 KW - ESR KW - desferrioxamine KW - free radicals KW - nitroxide KW - xanthine oxidase KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14926911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=The+enzymatic+oxidation+of+Desferal+to+a+nitroxide+free+radical.&rft.au=Morehouse%2C+K+M%3BFlitter%2C+W+D%3BMason%2C+R+P&rft.aulast=Morehouse&rft.aufirst=K&rft.date=1987-01-01&rft.volume=222&rft.issue=2&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - The metabolism of N-nitrosobis(2-oxopropyl)amine by microsomes and hepatocytes from Fischer 344 rats. AN - 14870233; 1712918 AB - The metabolism of N-nitrosobis(2-oxopropyl)amine (BOP) was examined in microsomes from uninduced F-344 rats. Even when the conditions were varied, no metabolism of this compound was detected. On the other hand, freshly isolated hepatocytes from F-344 rats metabolized BOP efficiently to CO sub(2). The kinetics of conversion showed there were at least two components. The high affinity component had a K sub(m) of 0.13 mM while the lower had a K sub(m) of 1.3 mM. As products of the metabolism, N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) and N-nitrosobis(2-hydroxypropyl)amine (BHP) were found whereas little acetol and no N-nitrosomethyl-2-oxopropylamine (MOP) were detected. JF - Carcinogenesis AU - Farrelly, J G AU - Saavedra, JE AU - Kupper, R J AU - Stewart, M L AD - BRI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 1095 EP - 1099 VL - 8 IS - 8 SN - 0143-3334, 0143-3334 KW - metabolism KW - N-nitrosobis(2-oxopropyl)amine KW - rats KW - Toxicology Abstracts KW - microsomes KW - hepatocytes KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14870233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+metabolism+of+N-nitrosobis%282-oxopropyl%29amine+by+microsomes+and+hepatocytes+from+Fischer+344+rats.&rft.au=Farrelly%2C+J+G%3BSaavedra%2C+JE%3BKupper%2C+R+J%3BStewart%2C+M+L&rft.aulast=Farrelly&rft.aufirst=J&rft.date=1987-01-01&rft.volume=8&rft.issue=8&rft.spage=1095&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - microsomes; hepatocytes ER - TY - JOUR T1 - Combined effects of the mycotoxins aflatoxin B sub(1) and cyclopiazonic acid on Sprague-Dawley rats. AN - 14843738; 1676715 AB - This study was conducted to determine whether exposure to cyclopiazonic acid (CPA) and aflatoxin B sub(1) (AFB sub(1)) would alter the toxicity associated with exposure to either toxin individually. Weight loss in the three groups receiving 2.0 mg AFB sub(1)/kg/day occurred within 24 hr of the first doses. Feed consumption by these rats was 60% of that in other groups. Gross pathological findings were primarily limited to rats in the high AFB sub(1) group, and included icterus, shrunken liver and lesions in the kidney at the cortico-medullary junction. Microscopic changes were characteristic of aflatoxicosis. Glycocholic acid assays indicated liver damage only in those that received the high AFB sub(1) dose. The authors conclude that neither toxin potentiates the action of the other at the dose levels used. JF - Food and Chemical Toxicology AU - Morrissey, R E AU - Norred, W P AU - Hinton, D M AU - Cole, R J AU - Dorner, J W AD - NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 837 EP - 842 VL - 25 IS - 11 SN - 0278-6915, 0278-6915 KW - combination KW - toxicity KW - aflatoxin B1 KW - cyclopiazonic acid KW - rats KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts KW - liver KW - kidney KW - mycotoxins KW - K 03082:Mycotoxins KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14843738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Combined+effects+of+the+mycotoxins+aflatoxin+B+sub%281%29+and+cyclopiazonic+acid+on+Sprague-Dawley+rats.&rft.au=Morrissey%2C+R+E%3BNorred%2C+W+P%3BHinton%2C+D+M%3BCole%2C+R+J%3BDorner%2C+J+W&rft.aulast=Morrissey&rft.aufirst=R&rft.date=1987-01-01&rft.volume=25&rft.issue=11&rft.spage=837&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - liver; kidney; mycotoxins ER - TY - JOUR T1 - Maitotoxin stimulates phosphoinositide breakdown in neuroblastoma hybrid NCB-20 cells. AN - 14840946; 1678254 AB - Maitotoxin (MTX) was an extraordinarily potent stimulant of phosphoinositide breakdown in the neuroblastoma hybrid NCB-20 cells. Maximal responses were obtained at 0.25-0.5 ng MTX/ml, and resulted in increased formation of ( super(3)H)inositol mono-, bis-, and tripsphosphates. MTX-induced phosphoinositide breakdown in NCB-20 cells was not antagonized by organic (nifedipine, methoxyverapamil) or inorganic (Mn super(2+), Co super(2+), Cd super(2+)) calcium channel blockers. The results suggest that MTX either directly stimulates phosphoinositide breakdown in a calcium-dependent manner or acts indirectly through calcium channels insensitive to organic/inorganic calcium channel blockers. JF - Cellular and Molecular Neurobiology AU - Gusovsky, F AU - Yasumoto, T AU - Daly, J W AD - Build. 8, Rm. 1A-15, NIDDK, NIH, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 317 EP - 318 VL - 7 IS - 3 SN - 0272-4340, 0272-4340 KW - hybrids KW - metabolism KW - stimulation KW - mice KW - phosphoinositides KW - maitotoxin KW - neuroblastoma cells KW - Toxicology Abstracts; Biochemistry Abstracts 1: Biological Membranes (till 1993); CSA Neurosciences Abstracts KW - X 24171:Microbial KW - N3 11070:Neurochemistry and cellular biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14840946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+Molecular+Neurobiology&rft.atitle=Maitotoxin+stimulates+phosphoinositide+breakdown+in+neuroblastoma+hybrid+NCB-20+cells.&rft.au=Gusovsky%2C+F%3BYasumoto%2C+T%3BDaly%2C+J+W&rft.aulast=Gusovsky&rft.aufirst=F&rft.date=1987-01-01&rft.volume=7&rft.issue=3&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Cellular+and+Molecular+Neurobiology&rft.issn=02724340&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - neuroblastoma cells ER - TY - JOUR T1 - Risk of astrocytic brain tumors associated with occupational chemical exposures. AN - 14836588; 1683456 AB - A case-referent study was conducted on the risk of brain tumors among workers exposed to organic chemicals in petroleum refining and chemical manufacturing. Brain tumor cases in northern New Jersey, Philadelphia, and the Gulf Coast of Louisiana were identified from death certificates of a recent three-year period. The cases (N = 300) were white men aged greater than or approximate to 30 years with a confirmed diagnosis of glioblastoma multiforme, astrocytoma, or a mixed glioma with astrocytic cells. The references were white mean who died from causes other than brain tumor, epilepsy, cerebrovascular disease, suicide, or homicide and were frequency-matched with the case on age at death, year of death, and study area. JF - Scandinavian Journal of Work, Environment & Health AU - Thomas, T L AU - Stewart, P A AU - Stemhagen, A AU - Correa, P AU - Norman, SA AU - Bleecker, M L AU - Hoover, R N AD - Environ. Epidemiol. Branch, NCI, Landow Build., Rm. 3C07, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 417 EP - 423 VL - 13 IS - 5 SN - 0355-3140, 0355-3140 KW - occupational health KW - tumors KW - man KW - petroleum KW - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - organic compounds KW - brain KW - occupational exposure KW - H SI6.8.2:CHEMICALS (CORROSION) KW - H SI3.8.2:CHEMICALS (CORROSION) KW - H SM6.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14836588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.atitle=Risk+of+astrocytic+brain+tumors+associated+with+occupational+chemical+exposures.&rft.au=Thomas%2C+T+L%3BStewart%2C+P+A%3BStemhagen%2C+A%3BCorrea%2C+P%3BNorman%2C+SA%3BBleecker%2C+M+L%3BHoover%2C+R+N&rft.aulast=Thomas&rft.aufirst=T&rft.date=1987-01-01&rft.volume=13&rft.issue=5&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - petroleum; occupational exposure; brain; organic compounds; tumors; man ER - TY - JOUR T1 - A postmortem study of the effect of chronic opiate abuse on psychotomimetic binding sites of human frontal cortex. AN - 14826670; 1662453 AB - Membranes were prepared from area 8 of human frontal cortex harvested from five controls and five opiate addicts. Psychotomimetic binding sites were assayed using tritiated 1-(1-(2-thiethyl)cyclohexyl)piperidine (( super(3)H)TCP) to label phencyclidine binding sites and 1,3-Di(2-(5- super(3)H)tolyl)guanidine (( super(3)H)DTG) to label the "haldoperidol-sensitive sigma binding site." The results demonstrated no significant differences between the control and experimental groups, suggesting that in the region of the human brain sampled in this study, chronic abuse of opiates is not accompained by alterations in psychotomimetic binding sites. JF - Neuropeptides AU - Rothman, R B AU - Bykov, V AU - Cadet, J L AU - Kleinman, JE AD - Lab. Clin. Sci., NIMH, Build. 10-3D42, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 261 EP - 264 VL - 10 IS - 3 SN - 0143-4179, 0143-4179 KW - receptors KW - binding KW - characterization KW - autopsy KW - man KW - cortex (frontal) KW - drug addiction KW - opiates KW - Biochemistry Abstracts 1: Biological Membranes (till 1993); Toxicology Abstracts KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14826670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropeptides&rft.atitle=A+postmortem+study+of+the+effect+of+chronic+opiate+abuse+on+psychotomimetic+binding+sites+of+human+frontal+cortex.&rft.au=Rothman%2C+R+B%3BBykov%2C+V%3BCadet%2C+J+L%3BKleinman%2C+JE&rft.aulast=Rothman&rft.aufirst=R&rft.date=1987-01-01&rft.volume=10&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Neuropeptides&rft.issn=01434179&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - cortex (frontal); opiates; drug addiction ER - TY - JOUR T1 - N-methyl-N'-nitro-N-nitrosoguanidine and benzo(a)pyrene-7,8-diol-9,10-epoxide inhibit glucocorticoid-inducible polyoma virus middle-T gene expression in rat mT-1 cells by a post-transcriptional mechanism. AN - 14826366; 1689207 AB - Treatment of rat mT-1 cells with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) inhibited the steroid-induced expression of the polyoma virus middle-T (mT) gene. Following a 1-h treatment period with either 100 ng/ml of MNNG or 100 ng/ml of BPDE, administration of 1 mu M dexamethasone (DEX) for 24 h resulted in, respectively, 51 and 33% less induction of phosphorylated mT protein in carcinogen-treated than in solvent-treated cells. MNNG appeared to increase the basal level of phosphorylated mT antigen expression by 44%, whereas BPDE had little or no effect on the level of phosphorylated mT protein in uninduced cells. MNNG and BPDE had little or no effect on the level of total steroid-induced mT RNA following addition of DEX for 4 or 20 h. JF - Carcinogenesis AU - Miller AU - Kono, M AU - Wogan, G N AD - Lab. Comp. Carcinog., NCI, Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 1159 EP - 1163 VL - 8 IS - 8 SN - 0143-3334, 0143-3334 KW - inhibition KW - N-methyl-N'-nitro-N-nitrosoguanidine KW - benzo(a)pyrene-7,8-diol-9,10-epoxide KW - polyoma virus KW - Virology & AIDS Abstracts; Toxicology Abstracts KW - gene expression KW - X 24190:Polycyclic hydrocarbons KW - X 24200:Nitrosamines & related compounds KW - V 22112:Animal DNA tumor viruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14826366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=N-methyl-N%27-nitro-N-nitrosoguanidine+and+benzo%28a%29pyrene-7%2C8-diol-9%2C10-epoxide+inhibit+glucocorticoid-inducible+polyoma+virus+middle-T+gene+expression+in+rat+mT-1+cells+by+a+post-transcriptional+mechanism.&rft.au=Miller%3BKono%2C+M%3BWogan%2C+G+N&rft.aulast=Miller&rft.aufirst=&rft.date=1987-01-01&rft.volume=8&rft.issue=8&rft.spage=1159&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - gene expression ER - TY - JOUR T1 - Suppression of the cytotoxic T-lymphocyte response in mice by pertussis toxin. AN - 14820109; 1663482 AB - Pertussis toxin (PT), the major toxin produced by Bordetella pertussis , has been reported both to enhance and to suppress immune responsiveness. These findings suggested that PT contributes to the virulence of B. pertussis through mechanisms involving immune regulation. The authors report that PT suppressed both the primary and the secondary cytotoxic T-lymphocyte (CTL) responses of mouse spleen cells cultured against two different allogeneic stimulator spleen cells in vitro. This suppression was dependent on the dose of PT used. PT must be present during the initial stages (within the first 24 hr) of CTL generation. Soluble factor(s) obtained from spleen cells preexposed to PT did not suppress the CTL generation. Soluble factor(s) obtained from spleen cells preexposed to PT did not suppress the CTL response. The cytotoxic activity of CTL clones could not be suppressed by PT. The analysis of responder spleen cells, fractionated by anti-immunoglobulin panning techniques, provided evidence that L3T4 super(-). Lyt 2 super(+) cells mediate the PT-induced immunosuppression. The authors propose that suppression of the CTL response by PT is generated through the activation of L3T4 super(-), Lyt 2 super(+) suppressor T lymphocytes. JF - Cellular Immunology AU - Arora, P K AU - Sekura, R D AU - Hanna, EE AD - Lab. Dev. and Mol. Immun., NICHD, Natl. Inst. Health, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 1 EP - 13 VL - 110 IS - 1 SN - 0008-8749, 0008-8749 KW - suppression KW - cytotoxicity KW - mice KW - Toxicology Abstracts; Immunology Abstracts KW - lymphocytes T KW - toxins KW - pertussis KW - X 24171:Microbial KW - F 06801:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14820109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Immunology&rft.atitle=Suppression+of+the+cytotoxic+T-lymphocyte+response+in+mice+by+pertussis+toxin.&rft.au=Arora%2C+P+K%3BSekura%2C+R+D%3BHanna%2C+EE&rft.aulast=Arora&rft.aufirst=P&rft.date=1987-01-01&rft.volume=110&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Cellular+Immunology&rft.issn=00088749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - pertussis; toxins; lymphocytes T ER - TY - CONF T1 - Effects of tobacco smoke components on cellular and biochemical processes in the lung. AN - 14816619; 1669306 JF - American Journal of Respiratory and Critical Care Medicine AU - Janoff, A AU - Pryor, WA AU - Bengali, Z H Y1 - 1987 PY - 1987 DA - 1987 SP - 1058 EP - 1064 VL - 136 IS - 4 KW - effects on KW - biochemistry KW - cell biology KW - Toxicology Abstracts KW - cigarette smoke KW - lung KW - reviews KW - tobacco KW - man KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14816619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Effects+of+tobacco+smoke+components+on+cellular+and+biochemical+processes+in+the+lung.&rft.au=Janoff%2C+A%3BPryor%2C+WA%3BBengali%2C+Z+H&rft.aulast=Janoff&rft.aufirst=A&rft.date=1987-01-01&rft.volume=136&rft.issue=4&rft.spage=1058&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Cytochrome P-450 isozymes 2 and 5 in rabbit lung and liver. Comparisons of structure and inducibility. AN - 14814228; 1653290 AB - Rabbit cytochrome P-450 isozymes 2 and 5 were purified from pulmonary and hepatic microsomal preparations. Purification of isozyme 5 was monitored by immunochemical methods so that contamination by isozymes 2, 4, and 6 could be avoided. Partial proteolysis of hepatic and pulmonary isozyme 5 showed minor differences in peptide formation when analyzed by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and visualized by the silver staining method. In contrast, identical patterns were observed when the peptides were transferred to nitrocellulose paper and visualized immunochemically. JF - Drug Metabolism and Disposition AU - Parandoosh, Z AU - Fujita, V S AU - Coon, MJ AU - Philpot, R M AD - Lab. Pharmacol., (MD 19-08), NIEHS/NIH, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 59 EP - 67 VL - 15 IS - 1 SN - 0090-9556, 0090-9556 KW - characterization KW - cytochrome P450 KW - isoenzymes KW - lung KW - purification KW - rabbits KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14814228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Metabolism+and+Disposition&rft.atitle=Cytochrome+P-450+isozymes+2+and+5+in+rabbit+lung+and+liver.+Comparisons+of+structure+and+inducibility.&rft.au=Parandoosh%2C+Z%3BFujita%2C+V+S%3BCoon%2C+MJ%3BPhilpot%2C+R+M&rft.aulast=Parandoosh&rft.aufirst=Z&rft.date=1987-01-01&rft.volume=15&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Drug+Metabolism+and+Disposition&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Mortality among workers in a shoe manufacturing company. AN - 14800773; 1650877 AB - Several epidemiologic studies have suggested that leather workers have an elevated risk of bladder cancer, nasal cancer, and leukemia. A case-control analysis of patient files at a large cancer treatment facility in New York State indicated that several bladder cancer patients had worked at a large shoe manufacturing company in upstate New York. A mortality study was initiated to determine whether there was an unusual cancer risk associated with employment in this facility. Proportionate mortality analyses were conducted by using 4,734 death certificates and the general U.S. population for comparison. There were no excess deaths from nasal cancer or bladder cancer, and mortality from leukemia was slightly lower than expected. Increased relative frequencies of digestive cancers were seen among men and women. There were significant excesses of deaths from multiple mmyeloma among both men and women. JF - American Journal of Industrial Medicine AU - Walrath, J AU - Decoufle, P AU - Thomas, T L AD - Occup. Stud. Sect., EEB, NCI, Landow Build., Rm. 4C16, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 615 EP - 623 VL - 12 IS - 5 SN - 0271-3586, 0271-3586 KW - workers KW - correlation KW - shoe manufacturing KW - leather KW - multiple myeloma KW - carcinoma KW - man KW - tanning industry KW - manufacturing industry KW - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - mortality KW - risk assessment KW - cancer KW - H SI2.29:TANNERIES KW - H SM6.8.2:CHEMICALS (CORROSION) KW - H SM10.21:CANCER KW - P 6000:TOXICOLOGY AND HEALTH KW - H SI8.8.2:CHEMICALS (CORROSION) KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14800773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Mortality+among+workers+in+a+shoe+manufacturing+company.&rft.au=Walrath%2C+J%3BDecoufle%2C+P%3BThomas%2C+T+L&rft.aulast=Walrath&rft.aufirst=J&rft.date=1987-01-01&rft.volume=12&rft.issue=5&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - mortality; tanning industry; cancer; risk assessment; manufacturing industry; leather; multiple myeloma; carcinoma; man ER - TY - JOUR T1 - US prevalence of occupational pleural thickening. A look at chest X-rays from the first national health and nutrition examination survey. AN - 14778712; 1631628 AB - The prevalence of occupational pleural thickening in the United States in the mid-1970s was estimated; since asbestos often produces pleural thickening, this estimate in turn was used to estimate the prevalence of asbestos exposure. Chest x-rays obtained by the 1971-1975 National Health and Nutrition Examination Survey were reread by three readers using the International Labour Office criteria for diagnosis of pleural thickening consistent with dust exposure. The authors showed that 2.3% of males and 0.2% of females had occupational pleural thickening on x-ray, with a strong increase with age in white males. This provides a US population estimate of 1.3 million people with occupational pleural thickening and approximately 8 million people with asbestos exposure in the mid-1970s. This cohort might make a substantial contribution to cancer mortality into the nest century. JF - American Journal of Epidemiology AU - Rogan, W J AU - Gladen, B C AU - Ragan, N B AU - Anderson, HA AD - NIEHS, Mail Drop A3-02, POB 12233, Research Triangle Park, NC 27709, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 893 EP - 900 VL - 126 IS - 5 SN - 0002-9262, 0002-9262 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - asbestos KW - epidemiology KW - radiology KW - surveys KW - respiratory diseases KW - H SM3.1:BASIC APPROACHES, CONCEPTS, AND THEORY KW - H SM6.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH KW - H SM10.24:PULMONARY DISEASES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14778712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=US+prevalence+of+occupational+pleural+thickening.+A+look+at+chest+X-rays+from+the+first+national+health+and+nutrition+examination+survey.&rft.au=Rogan%2C+W+J%3BGladen%2C+B+C%3BRagan%2C+N+B%3BAnderson%2C+HA&rft.aulast=Rogan&rft.aufirst=W&rft.date=1987-01-01&rft.volume=126&rft.issue=5&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - surveys; asbestos; respiratory diseases; radiology; epidemiology ER - TY - JOUR T1 - Occupational cancer risk associated with the storage and bulk handling of agricultural foodstuff. AN - 14774847; 1632428 AB - The cancer mortality experience of 2649 Swedish grain millers was followed during the period from 1961 to 1979. Although the overall cancer incidence was not elevated, the risk of primary liver cancer was significantly elevated for this group. The Swedish data is compared to the cancer mortality experience of workers in the Netherlands and the United States who are also involved in the bulk handling and storage of agricultural foodstuffs. The varying occupational exposures in this international comparison help establish etiologic hypotheses in the absence of comprehensive exposure information. Agents of potential concern include metabolic products of fungal contaminants and pesticides used to protect grain from insect infestation. JF - Journal of Toxicology and Environmental Health AU - Alavanja, MCR AU - Malker, H AU - Hayes, R B AD - NCI, NIH, Public Health Serv., DHHS, Landow Build., Rm. 4C03, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 247 EP - 254 VL - 22 IS - 3 SN - 0093-4108, 0093-4108 KW - workers KW - health KW - risks KW - exposure KW - grain KW - man KW - occupational health KW - materials handling KW - food processing industry KW - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - mycotoxins KW - risk assessment KW - pesticides KW - storage KW - H SE4.27:FOOD PROCESSING INDUSTRIES KW - X 24171:Microbial KW - X 24132:Chronic exposure KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14774847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=Occupational+cancer+risk+associated+with+the+storage+and+bulk+handling+of+agricultural+foodstuff.&rft.au=Alavanja%2C+MCR%3BMalker%2C+H%3BHayes%2C+R+B&rft.aulast=Alavanja&rft.aufirst=MCR&rft.date=1987-01-01&rft.volume=22&rft.issue=3&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - pesticides; mycotoxins; occupational health; risk assessment; storage; materials handling; food processing industry; grain; man ER - TY - JOUR T1 - Immunohistochemical localization of human and simian immunodeficiency viral antigens in fixed tissue sections. AN - 14772814; 1628118 AB - Antigens of human (HIV) or simian immunodeficiency viruses (SIV) were identified with polyclonal or monoclonal antibodies and avidin-biotin complex (ABC) immunohistochemistry in fixed surgical pathology and autopsy specimens of humans or monkeys with the acquired immunodeficiency syndrome. With B-5 fixative, viral antigens were readily detected in lymph nodes of 8 of 13 patients with follicular hyperplasia, but on only 1 of 12 patients with follicular atrophy. Antigen was detected in follicular dendritic reticular cells and rare blastlike cells, extracellularly, and in postcapillary venules, medullary lymphocytes, sinus histiocytes, and macrophages in some lymph nodes. In the brain at autopsy, antigen could be found in gliomesenchymal-cell nodules, astrocytes, vascular endothelial cells, multinucleated cells, astrocytes and macrophages associated with demyelination. In contrast, 4 rhesus monkeys with experimental SIV infection had abundant antigen in sinus histiocytes, macrophages, and multinucleated giant cells of lymph nodes and spleen and in thymic epithelial cells. JF - American Journal of Pathology AU - Ward, J M AU - O'Leary, T J AU - Baskin, G B AU - Benveniste, R AU - Harris, CA AU - Nara, P L AU - Rhodes, R H AD - NCI-FCRF, Build. 538, Frederick, MD 21701-1013, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 199 EP - 205 VL - 127 IS - 2 SN - 0002-9440, 0002-9440 KW - immunohistochemistry KW - tissues KW - man KW - monkeys KW - T cell leukemia virus (simian) III KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - human immunodeficiency virus KW - antigens KW - acquired immune deficiency syndrome KW - A 01114:Viruses KW - V 22003:AIDS: Immunological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14772814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Pathology&rft.atitle=Immunohistochemical+localization+of+human+and+simian+immunodeficiency+viral+antigens+in+fixed+tissue+sections.&rft.au=Ward%2C+J+M%3BO%27Leary%2C+T+J%3BBaskin%2C+G+B%3BBenveniste%2C+R%3BHarris%2C+CA%3BNara%2C+P+L%3BRhodes%2C+R+H&rft.aulast=Ward&rft.aufirst=J&rft.date=1987-01-01&rft.volume=127&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Pathology&rft.issn=00029440&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - human immunodeficiency virus; antigens; acquired immune deficiency syndrome ER - TY - JOUR T1 - Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: Effects on growth, morbidity, and duration of lactation. AN - 14752875; 1613099 AB - The authors followed 858 children from birth to one year of age to determine whether the presence of polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in breast milk affected their growth or health. Neither chemical showed an adverse effect on weight or frequency of physician visits for various illnesses, although differences were seen between breast-fed and bottle-fed children, with bottle-fed children being heavier and having more frequent gastroenteritis and otitis media. Children of mothers with higher levels of DDE were breast-fed for markedly shorter times, but adjustments for possible confounders and biases did not change the findings. In absence of any apparent effect on the health of the children, they speculate that DDE may be interfering with the mother's ability to lactate, possibly because of its estrogenic properties. JF - American Journal of Public Health AU - Rogan, W J AU - Gladen, B C AU - McKinney, J D AU - Carreras, N AU - Hardy, P AU - Thullen, J AU - Tingelstad, J AU - Tully, M AD - A3-02, NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 1294 EP - 1297 VL - 77 IS - 10 SN - 0090-0036, 0090-0036 KW - effects on KW - growth KW - PCB KW - lactation KW - man KW - DDE KW - PCB compounds KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - breast milk KW - mortality KW - X 24120:Food, additives & contaminants KW - X 24132:Chronic exposure KW - H SE4.20:POISONS AND POISONING KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14752875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Polychlorinated+biphenyls+%28PCBs%29+and+dichlorodiphenyl+dichloroethene+%28DDE%29+in+human+milk%3A+Effects+on+growth%2C+morbidity%2C+and+duration+of+lactation.&rft.au=Rogan%2C+W+J%3BGladen%2C+B+C%3BMcKinney%2C+J+D%3BCarreras%2C+N%3BHardy%2C+P%3BThullen%2C+J%3BTingelstad%2C+J%3BTully%2C+M&rft.aulast=Rogan&rft.aufirst=W&rft.date=1987-01-01&rft.volume=77&rft.issue=10&rft.spage=1294&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - DDE; mortality; breast milk; PCB compounds; lactation; man ER - TY - JOUR T1 - Relative mutagenic and prophage-inducing effects of mono- and di-alkyl nitrosoureas. AN - 14746994; 1616844 AB - Mutagenic capacity, prophage-inducing ability, and decomposition rates of mono- and di-alkylnitrosoureas with the same alkyl groups were studied in aqueous systems using S. typhimurium strains TA1535 and E. coli strain BR339 (lambda). Slower decomposition rates of nitrosodialkylureas compared with monoalkylnitrosoureas were not reflected in reduced mutagenicity, with the exception of methylating agents. With the monoalkylnitrosoureas, mutagenicity varied with length of the alkyl chain and was greatly increased by oxygen substituents. Among the dialkylnitrosoureas, mutagenesis and decomposition rates were dependent on the substituent in the N-1 position, adjacent to the nitroso group. Prophage induction, on the other hand, was dependent on a substituent in the N-3 position. The results suggested the existence of two distinct mechanisms for DNA damage, one SOS-dependent and the other SOS-independent, by which different dialkylnitrosoureas acted. JF - Mutation Research AU - Lijinsky, W AU - Elespuru, R K AU - Andrews, A W AD - NCI-Frederick Cancer Res. Fac., LBI-Basic Res. Program, Frederick, MD 21701, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 157 EP - 165 VL - 178 IS - 2 SN - 0027-5107, 0027-5107 KW - induction KW - monoalkylnitrosourea KW - dialkylnitrosourea KW - Toxicology Abstracts KW - Escherichia coli KW - prophages KW - Salmonella typhimurium KW - mutagenicity KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14746994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Relative+mutagenic+and+prophage-inducing+effects+of+mono-+and+di-alkyl+nitrosoureas.&rft.au=Lijinsky%2C+W%3BElespuru%2C+R+K%3BAndrews%2C+A+W&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1987-01-01&rft.volume=178&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Salmonella typhimurium; Escherichia coli; mutagenicity; prophages ER - TY - JOUR T1 - Effects of chronic ethanol treatment on the beta -adrenergic receptor-coupled adenylate cyclase system of mouse cerebral cortex. AN - 14742184; 1604491 AB - Chronic ingestion of ethanol, which produced tolerance and physical dependence, resulted in altered function of the cerebral cortical beta -adrenergic receptor-coupled adenylate cyclase system in mice. Although there was no change in basal adenylate cyclase activity, or in the activity of the digitonin-solubilized catalytic unit, stimulation of adenylate cyclase activity by the nonhydrolyzable guanine nucleotide analog guanylylimidodiphosphate (Gpp(NH)p) was reduced in brains of ethanol-fed animals. The results are consistent with a qualitative or quantitative defect in the function of the stimulatory guanine nucleotide-binding protein (N sub(s)), as well as in the beta -adrenergic receptor, after chronic ethanol exposure. JF - Journal of Neurochemistry AU - Saito, T AU - Lee, J M AU - Hoffman, P L AU - Tabakoff, B AD - NIAAA/LPPS, 12501 Washington Ave., Rm. 15, Rockville, MD 20852, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 1817 EP - 1825 VL - 48 IS - 6 SN - 0022-3042, 0022-3042 KW - chronic effects KW - receptors KW - complex KW - activity KW - ethanol KW - beta -adrenergic KW - adenylate cyclase KW - mice KW - cortex KW - Toxicology Abstracts; Biochemistry Abstracts 1: Biological Membranes (till 1993); CSA Neurosciences Abstracts KW - N3 11070:Neurochemistry and cellular biology KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14742184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Effects+of+chronic+ethanol+treatment+on+the+beta+-adrenergic+receptor-coupled+adenylate+cyclase+system+of+mouse+cerebral+cortex.&rft.au=Saito%2C+T%3BLee%2C+J+M%3BHoffman%2C+P+L%3BTabakoff%2C+B&rft.aulast=Saito&rft.aufirst=T&rft.date=1987-01-01&rft.volume=48&rft.issue=6&rft.spage=1817&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - cortex ER - TY - JOUR T1 - Changes in local cerebral glucose utilization associated with Parkinson's syndrome induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the primate. AN - 14741602; 1604640 AB - The quantitative 2-( super(14)C)deoxyglucose autoradiographic method was used to map the pattern of alterations in local cerebral glucose utilization associated with the Parkinsonian syndrome induced by the administration of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), to rhesus monkeys. Glucose utilization was significantly reduced in the pars compacta of the substantia nigra and in the subthalamus, and increased in the external segment of the globus pallidus. The results indicate that the profound functional and behavioral deficits in MPTP-induced Parkinson's syndrome are the consequences of highly selective functional changes in a few cerebral structures, mainly within the basal ganglia. JF - Life Sciences AU - Porrino, L J AU - Burns, R S AU - Crane, A M AU - Palombo, E AU - Kopin, I J AU - Sokoloff, L AD - Lab. Cereb. Metab., NIMH, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 1657 EP - 1664 VL - 40 IS - 17 SN - 0024-3205, 0024-3205 KW - changes KW - induction KW - MPTP KW - monkeys KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - glucose metabolism KW - Parkinson's disease KW - Macaca mulatta KW - cerebrum KW - X 24155:Biochemistry KW - N3 11070:Neurochemistry and cellular biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14741602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+Sciences&rft.atitle=Changes+in+local+cerebral+glucose+utilization+associated+with+Parkinson%27s+syndrome+induced+by+1-methyl-4-phenyl-1%2C2%2C3%2C6-tetrahydropyridine+%28MPTP%29+in+the+primate.&rft.au=Porrino%2C+L+J%3BBurns%2C+R+S%3BCrane%2C+A+M%3BPalombo%2C+E%3BKopin%2C+I+J%3BSokoloff%2C+L&rft.aulast=Porrino&rft.aufirst=L&rft.date=1987-01-01&rft.volume=40&rft.issue=17&rft.spage=1657&rft.isbn=&rft.btitle=&rft.title=Life+Sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Macaca mulatta; cerebrum; glucose metabolism; Parkinson's disease ER - TY - JOUR T1 - Pathologic changes following acute methyl isocyanate inhalation and recovery in B6C3F1 mice. AN - 14734626; 1592826 AB - Male and female mice were exposed by inhalation to 0, 3, 10, and 30 ppm methyl isocyanate for 2 hr followed by a 91-day recovery period. Sixteen of 80 (20%) male mice in the 30-ppm group died following exposure with seven deaths occurring in the first 24 hr. Two female mice died, one each in the 30-and 10-ppm concentration groups. Five mice/sex/group were examined at 2 hr and at 1, 3, 7, 14, 28, 49, and 91 days following exposure. Treatment-related changes were restricted to the respiratory system. At 30 ppm there was extensive necrosis and erosion of the respiratory and olfactory epithelia in the nasal cavity. Severe necrosis and epithelial erosion were also found in the trachea and main bronchi. These inhalation studies indicate that methyl isocyanate exposure of mice at or near lethal concentrations causes reversible lesions in the nose and persistent intraluminal and mural fibrosis of the major bronchi. JF - Toxicology and Applied Pharmacology AU - Boorman, G A AU - Brown, R AU - Gupta, B N AU - Uraih, L C AU - Bucher, J R AD - Chem. Pathol. Branch, Natl. Toxicol. Program, NIEHS, Research Triangle Park, NC 27709, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 446 EP - 456 VL - 87 IS - 3 SN - 0041-008X, 0041-008X KW - effects on KW - methyl isocyanate KW - respiratory systems KW - mice KW - Toxicology Abstracts KW - inhalation KW - necrosis KW - X 24151:Acute exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14734626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Pathologic+changes+following+acute+methyl+isocyanate+inhalation+and+recovery+in+B6C3F1+mice.&rft.au=Boorman%2C+G+A%3BBrown%2C+R%3BGupta%2C+B+N%3BUraih%2C+L+C%3BBucher%2C+J+R&rft.aulast=Boorman&rft.aufirst=G&rft.date=1987-01-01&rft.volume=87&rft.issue=3&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - necrosis; inhalation ER - TY - JOUR T1 - Cancer in patients receiving long-term dialysis treatment. AN - 14729411; 1583828 AB - A large excess of non-Hodgkin's lymphoma has been documented in renal transplant patients and may be related to immunosuppressive therapy, persistent antigenic challenge from the graft, or both. To determine whether immunosuppression resulting from chronic renal failure is associated with an elevated risk of certain tumors such as non-Hodgkin's lymphoma, the authors studied cancer incidence in a national cohort of 28,049 patients in the United States with chronic renal failure who received maintenance dialysis for at least six months (totaling 66,706 person-years of observation). Compared with national incidence rates, the relative risk (RR) of cancer was 0.9 (excluding nonmelanoma skin cancer, multiple myeloma, kidney cancer, and uterine cervix cancer). Moderate excesses of leukemia, non-Hodgkin's lymphoma, Hodgkin's disease, thyroid cancer, and biliary tract cancer were found, but were not statistically significant for both sexes combined. A significantly elevated risk of non-Hodgkin; s lymphoma among patients with chronic glomerulonephritis (PR = 2.6) accounted for the excess observed in the total series, raising the possibility of factors specific to this disease. JF - American Journal of Epidemiology AU - Kantor, A F AU - Hoover, R N AU - Kinlen, L J AU - McMullan, M R AU - Fraumeni, JF Jr AD - NCI Field Stn., Dana-Farber Cancer Inst., Dana 1110, 44 Binney St., Boston, MA 02115, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 370 EP - 376 VL - 126 IS - 3 SN - 0002-9262, 0002-9262 KW - kidneys KW - Health & Safety Science Abstracts KW - dialysis KW - cancer KW - H SM10.21:CANCER UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14729411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Cancer+in+patients+receiving+long-term+dialysis+treatment.&rft.au=Kantor%2C+A+F%3BHoover%2C+R+N%3BKinlen%2C+L+J%3BMcMullan%2C+M+R%3BFraumeni%2C+JF+Jr&rft.aulast=Kantor&rft.aufirst=A&rft.date=1987-01-01&rft.volume=126&rft.issue=3&rft.spage=370&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - cancer; dialysis ER - TY - JOUR T1 - Stereoselective formation of benzo(c)phenanthrene (+)-(3S,4R) and (+)-(5S,6R)-oxides by cytochrome P450c in a highly purified and reconstituted system. AN - 14715739; 1571373 AB - The principal oxidative metabolites formed from benzo(c)phenanthrene (B(c)Ph) by the cytochromes P450 in liver microsomes from control and treated rats are the 3,4- and 5,6-arene oxides. A procedure is described which allows determination of the enantiomer composition and absolute configuration of these arene oxides based on HPLC separation of isomeric thiolate adducts formed with N-acetyl-L-cysteine in base. JF - Biochemical and Biophysical Research Communications AU - van Bladeren, PJ AU - Balani, S K AU - Sayer, J M AU - Thakker AU - Boyd AU - Ryan, DE AU - Thomas, P E AU - Levin, W AU - Jerina, D M AD - Lab. Bioorg. Chem., NIDDK, Natl. Inst. Health, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 160 EP - 167 VL - 145 IS - 1 SN - 0006-291X, 0006-291X KW - cytochrome P450c KW - liver KW - microsomes KW - rats KW - stereoselectivity KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14715739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Stereoselective+formation+of+benzo%28c%29phenanthrene+%28%2B%29-%283S%2C4R%29+and+%28%2B%29-%285S%2C6R%29-oxides+by+cytochrome+P450c+in+a+highly+purified+and+reconstituted+system.&rft.au=van+Bladeren%2C+PJ%3BBalani%2C+S+K%3BSayer%2C+J+M%3BThakker%3BBoyd%3BRyan%2C+DE%3BThomas%2C+P+E%3BLevin%2C+W%3BJerina%2C+D+M&rft.aulast=van+Bladeren&rft.aufirst=PJ&rft.date=1987-01-01&rft.volume=145&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Characterization of the rearranged tpr-met oncogene breakpoint. AN - 14706129; 1570981 AB - The authors determined the nucleotide sequence of the rearranged trp-met genomic locus and the corresponding portions of the unrearranged tpr and met genomic fragments. The breakpoints occur at one end of a stretch of 21 A residues that follow an Alu repetitive sequence in the tpr locus and within a group of 3 A residues in the met proto-oncogene locus. The authors concluded that the fusion between the tpr locus on chromosome 1 and the met locus on chromosome 7 resulted from a recombination event. JF - Molecular and Cellular Biology AU - Dean, M AU - Park, M AU - Vande Woude, GF AD - BRI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 921 EP - 924 VL - 7 IS - 2 SN - 0270-7306, 0270-7306 KW - cell lines KW - treatment KW - oncogenes KW - tpr gene KW - met gene KW - rearrangement KW - breakpoint KW - N-methyl-N'-nitro-N-nitrosoguanidine KW - cloning KW - genes KW - man KW - nucleotide sequence KW - osteosarcoma KW - transduction KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - N 14640:Structure & sequence KW - W 30121:Transduction and transfection KW - G 07430:Chromosome studies/nucleotide sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14706129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Characterization+of+the+rearranged+tpr-met+oncogene+breakpoint.&rft.au=Dean%2C+M%3BPark%2C+M%3BVande+Woude%2C+GF&rft.aulast=Dean&rft.aufirst=M&rft.date=1987-01-01&rft.volume=7&rft.issue=2&rft.spage=921&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - man; osteosarcoma; genes; nucleotide sequence; cloning; transduction ER - TY - JOUR T1 - In vitro metabolism of etoposide (VP-16-213) by liver microsomes and irreversible binding of reactive intermediates to microsomal proteins. AN - 14693673; 1555108 AB - The authors have studied the metabolism of VP-16-213, an antitumor agent, by mouse liver microsomes to reactive intermediates and the subsequent covalent binding to microsomal proteins. This metabolism was shown to involve the O-demethylation of VP-16 and resulted in the formation of a 3',4'-dihydroxy derivative (DHVP-16) which was identified by both HPLC and mass spectrometry. The formation of DHVP-16 was cytochrome P-450-mediated as indicated by its dependence on NADPH, its increased production following treatment of mice with phenobarbital, and its marked inhibition by SKF-525A and piperonyl butoxide. DHVP-16 formation required oxygen. Microsomal incubation of VP-16 resulted in an irreversible binding of the drug to the proteins, which was also shown to be cytochrome P-450 dependent. The covalent binding of the VP-16 metabolite(s) was inhibited by DHVP-16 in a dose-dependent fashion, suggesting that the reactive intermediates that bound to proteins were derived from DHVP-16. JF - Biochemical Pharmacology AU - Haim, N AU - Nemec, J AU - Roman, J AU - Sinha, B K AD - Clin. Oncol. Branch, NCI, Build. 10, Rm. 6N-119, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 527 EP - 536 VL - 36 IS - 4 SN - 0006-2952, 0006-2952 KW - metabolism KW - binding KW - proteins KW - in vitro KW - etoposide KW - mice KW - Toxicology Abstracts KW - microsomes KW - liver KW - antineoplastic drugs KW - X 24114:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14693673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Pharmacology&rft.atitle=In+vitro+metabolism+of+etoposide+%28VP-16-213%29+by+liver+microsomes+and+irreversible+binding+of+reactive+intermediates+to+microsomal+proteins.&rft.au=Haim%2C+N%3BNemec%2C+J%3BRoman%2C+J%3BSinha%2C+B+K&rft.aulast=Haim&rft.aufirst=N&rft.date=1987-01-01&rft.volume=36&rft.issue=4&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=Biochemical+Pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - liver; microsomes; antineoplastic drugs ER - TY - JOUR T1 - Resistance of 7,12-dimethylbenz(a)anthracene--deoxyadenosine adducts in DNA to hydrolysis by snake venom phosphodiesterase. AN - 14693593; 1555133 AB - In enzymatic hydrolyses of 7,12-dimethylbenz(a)anthracene (DMBA)-modified DNA isolated from fetal mouse cell cultures, a low concentration of venom phosphodiesterase was sufficient for complete release of DMBA - deoxyguanosine adducts. However, efficient release of DMBA - deoxyadenosine adducts required much higher levels of phosphodiesterase. If these adducts exhibit similarly differential susceptibilities to exonucleases involved in DNA metabolism or repair, each adduct could result in significantly different biological effects in vivo. JF - Carcinogenesis AU - Dipple, A AU - Pigott, MA AD - BRI-Basic Res. Program, Lab. Chem. and Phys., Carcinog., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 491 EP - 493 VL - 8 IS - 3 SN - 0143-3334, 0143-3334 KW - adducts KW - 9,10-dimethyl-1,2-benzanthracene KW - phosphodiesterase KW - mice KW - Toxicology Abstracts KW - cell culture KW - venom KW - DNA KW - hydrolysis KW - X 24190:Polycyclic hydrocarbons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14693593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Resistance+of+7%2C12-dimethylbenz%28a%29anthracene--deoxyadenosine+adducts+in+DNA+to+hydrolysis+by+snake+venom+phosphodiesterase.&rft.au=Dipple%2C+A%3BPigott%2C+MA&rft.aulast=Dipple&rft.aufirst=A&rft.date=1987-01-01&rft.volume=8&rft.issue=3&rft.spage=491&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - DNA; hydrolysis; venom; cell culture ER - TY - JOUR T1 - Cellular uptake and metabolic reduction of pentavalent to trivalent arsenic as determinants of cytotoxicity and morphological transformation. AN - 14691102; 1554979 AB - Cytotoxicity, morphological neoplastic transformation, cellular uptake and metabolic reduction were determined in BALB/3T3 Cl A31-1-1 cells for trivalent arsenic (sodium arsenite, As super(3+)) and for pentavalent arsenic (sodium arsenate, As super(5+). The levels of cellular uptake of ) super(7)3s)-labelled sodium arsenite and arsenate were dose-dependent and highest in the first hour. At equimolar concentration (3 X 10 super(-6) m), cellular uptake was 4-fold higher for As super(3+) than for As super(5+). Cytotoxicity was higher for As super(3+) than for As super(5+), but when correlated to total As cell burden it showed no significant difference for the two forms. Morphological transformation focus assays showed transforming activity for both As super(3+) and As super(5+), with relative transformation frequencies also of similar to 4:1. Recovery from the cytosol for 1 - 24 h was > 90% for either form absorbed As. Exposure to As super(3+) yielded 100% as As super(3+) in cytosol, but exposure to As super(5+) yielded > 70% as As super(3+), showing a high rate of intracellular metabolic reduction. The results suggest that As super(3+) is the form responsible for the cytotoxic and transforming effects, independently of the valence of the inorganic arsenic in the culture medium. JF - Carcinogenesis AU - Bertolero, F AU - Pozzi, G AU - Sabbioni, E AU - Saffiotti, U AD - Exp. Pathol., NCI Build. 37, R. 6D24, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 803 EP - 808 VL - 8 IS - 6 SN - 0143-3334, 0143-3334 KW - cytotoxicity KW - uptake KW - metabolism KW - sodium arsenite KW - sodium arsenate, dibasic KW - Toxicology Abstracts KW - cell culture KW - X 24165:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14691102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Cellular+uptake+and+metabolic+reduction+of+pentavalent+to+trivalent+arsenic+as+determinants+of+cytotoxicity+and+morphological+transformation.&rft.au=Bertolero%2C+F%3BPozzi%2C+G%3BSabbioni%2C+E%3BSaffiotti%2C+U&rft.aulast=Bertolero&rft.aufirst=F&rft.date=1987-01-01&rft.volume=8&rft.issue=6&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - cell culture ER - TY - JOUR T1 - Human creatine kinase-B complementary DNA: Nucleotide sequence, gene expression in lung cancer, and chromosomal assignment to two distinct loci. AN - 14687847; 1552802 AB - Using a small cell lung cancer (SCLC) cDNA library, the authors obtained clones for the creatine kinase-B (CK-B) gene and determined the nucleotide sequence for the protein coding and 3' untranslated region(3'UT). The human translated protein spans 381 residues and the amino acid homology with rabbit CK-B is > 98%. When a B-isoenzyme specific sequence is hybridized to Eco RI cut genomic DNA, two independent restriction fragment polymorphisms are detected. The authors have subsequently localized these two CK-B homologous sequences to chromosomes 14q32 and 16. Increased levels of CK-B seen in SCLC reflect a greatly enhanced level of CK-B specific mRNA that is not seen in non-SCLC lines thus far examined. JF - Journal of Clinical Investigation AU - Kaye, F J AU - McBride, O W AU - Battey, J F AU - Gazdar, A F AU - Sausville, E A AD - NCI-Navy Med. Oncol. Branch, Build. 8, Rm. 5101, Naval Hosp., Bethesda, MD 20814, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 1412 EP - 1420 VL - 79 IS - 5 SN - 0021-9738, 0021-9738 KW - amino acid sequence KW - cDNA KW - carcinoma KW - chromosomes KW - creatine kinase KW - gene expression KW - genes KW - isoenzyme B KW - lung KW - man KW - mapping KW - nucleotide sequence KW - predictions KW - restriction fragment length polymorphism KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - N 14640:Structure & sequence KW - G 07470:Cytogenetics & general KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14687847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Investigation&rft.atitle=Human+creatine+kinase-B+complementary+DNA%3A+Nucleotide+sequence%2C+gene+expression+in+lung+cancer%2C+and+chromosomal+assignment+to+two+distinct+loci.&rft.au=Kaye%2C+F+J%3BMcBride%2C+O+W%3BBattey%2C+J+F%3BGazdar%2C+A+F%3BSausville%2C+E+A&rft.aulast=Kaye&rft.aufirst=F&rft.date=1987-01-01&rft.volume=79&rft.issue=5&rft.spage=1412&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - nucleotide sequence; chromosomes; lung; cDNA; amino acid sequence; restriction fragment length polymorphism; genes; gene expression; man; carcinoma ER - TY - JOUR T1 - Observations and implications on the migration of calmodulin in a two-dimensional gel system. AN - 14683467; 1552411 AB - These studies investigated the effect of calcium on the migration of calmodulin in a two-dimensional (2-D) gel system. As reported for one-dimensional gels, calmodulin migrates on 2-D gels primarily as a 21 kDa protein in the presence of 0.1 mM EDTA, and as a 15 kDa protein in the presence of 0.1 mM CaCl sub(2). However, under basal conditions (i.e., neither EDTA nor calcium added to the buffer system), calmodulin migrates on a 2-D gel as doublet of 20.3 and 18.7 kDa. JF - Electrophoresis AU - Heydorn, W E AU - Creed, G J AU - Jacobowitz, D M AD - Lab. Clin. Sci., NIMH, Build. 10, Rm. 3D-48, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 251 EP - 252 VL - 8 IS - 5 SN - 0170-0835, 0170-0835 KW - calcium KW - calmodulin KW - effects on KW - gel electrophoresis KW - migration KW - Microbiology Abstracts B: Bacteriology; Calcium & Calcified Tissue Abstracts KW - T 20020:Calcium-binding agents KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14683467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electrophoresis&rft.atitle=Observations+and+implications+on+the+migration+of+calmodulin+in+a+two-dimensional+gel+system.&rft.au=Heydorn%2C+W+E%3BCreed%2C+G+J%3BJacobowitz%2C+D+M&rft.aulast=Heydorn&rft.aufirst=W&rft.date=1987-01-01&rft.volume=8&rft.issue=5&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Electrophoresis&rft.issn=01700835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - gel electrophoresis ER - TY - JOUR T1 - Comparisons of some behavioral effects of d-amphetamine and toluene. AN - 14670615; 1537615 AB - The levels of toluene affecting behavior were compared to those with lethal effects, for three different routes of administration. Low-to-intermediate concentrations increased responding and higher concentrations decreased responding while injections of toluene only decreased responding. d-Amphetamine injections increased nose-poke responding to a lesser extent than did inhalational exposure to toluene. The results characterize important situational-specific factors determining stimulant properties and behavioral toxicity of toluene which may apply to other volatile organic solvents. JF - Neurotoxicology AU - Glowa, J R AD - Biol. Psychiatry Branch, NIMH, Build. 36, Rm. 2D10, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 237 EP - 248 VL - 8 IS - 2 SN - 0161-813X, 0161-813X KW - effects on KW - factors affecting KW - toluene KW - mice KW - amphetamine KW - Animal Behavior Abstracts; Toxicology Abstracts; CSA Neurosciences Abstracts KW - behavior KW - neurotoxicity KW - X 24151:Acute exposure KW - X 24111:Acute exposure KW - Y 25817:Mammals (excluding primates) KW - N3 11139:Toxicological and psychoactive drug correlates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14670615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Comparisons+of+some+behavioral+effects+of+d-amphetamine+and+toluene.&rft.au=Glowa%2C+J+R&rft.aulast=Glowa&rft.aufirst=J&rft.date=1987-01-01&rft.volume=8&rft.issue=2&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - neurotoxicity; behavior ER - TY - JOUR T1 - Carcinogens with diverse mutagenic activities initiate neoplastic guinea pig cells that acquire the same N-ras point mutation. AN - 14666523; 1537253 AB - N-ras has been identified by molecular cloning and DNA sequence analysis as the activated oncogene in carcinogen-induced guinea pig transformation. The deduced guinea pig amino acid sequence differs from that of human and mouse by 1 and 4 residues, respectively; the mismatches were in the C-terminal half of the fourth exon. The activated N-ras clone has an AT to TA transversion at the third position of codon 61 which results in the insertion of histidine instead of glutamine. The same activated N-ras gene with the identical mutation was found in all lines regardless of initiating carcinogen (aromatic aryl hydrocarbons or alkylating agents). These results suggest that the mutational event was independent of the mutagenic activity of the initiating carcinogen. JF - Journal of Biological Chemistry AU - Doniger, J AU - Notario, V AU - DiPaolo, JA AD - NCI, Build. 37, Rm. 2A19, 9000 Rockville Pike, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 3813 EP - 3819 VL - 262 IS - 8 SN - 0021-9258, 0021-9258 KW - oncogenes KW - N-ras gene KW - transformation KW - tissue culture KW - guinea-pigs KW - Toxicology Abstracts; Genetics Abstracts KW - carcinogens KW - genes KW - point mutation KW - X 24240:Miscellaneous KW - G 07220:General theory/testing systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14666523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Carcinogens+with+diverse+mutagenic+activities+initiate+neoplastic+guinea+pig+cells+that+acquire+the+same+N-ras+point+mutation.&rft.au=Doniger%2C+J%3BNotario%2C+V%3BDiPaolo%2C+JA&rft.aulast=Doniger&rft.aufirst=J&rft.date=1987-01-01&rft.volume=262&rft.issue=8&rft.spage=3813&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - genes; carcinogens; point mutation ER - TY - JOUR T1 - Arthropod cell lines in the isolation and propagation of tickborne spiroplasmas. AN - 14664203; 1522651 AB - The ability of several continuous tick cell culture lines to support growth of tickborne spiroplasmas (helical, wall-less prokaryotes in the class Mollicutes) was assessed. Seven triturates, prepared from pools of Ixodes pacificus ticks naturally infected with the Spiroplasma sp. (group VI) organisms, were retrieved from frozen (-70 degree C) storage and passaged in three distinct tick cell lines, in antibiotic-free tick cell culture medium alone, or in spiroplasma culture medium (SP-4 formulation). Six spiroplasma strains were recovered in the RML-19 cell line from Dermacentor variabilis and five isolations were made in another cell line (RML-15) from this tick species. The use of arthropod cell lines appears to have value in the primary isolation of arthropod-or insect-derived mollicutes and for the study of cytopathogenicity of these wall-less prokaryotes. JF - Current Microbiology AU - Yunker, CE AU - Tully, J G AU - Cory, J AD - Mycoplasma Sect., NIAID, Build. 550, Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 45 EP - 50 VL - 15 IS - 1 SN - 0343-8651, 0343-8651 KW - isolation KW - propagation KW - Entomology Abstracts; Microbiology Abstracts B: Bacteriology KW - Ixodidae KW - Spiroplasma KW - Dermacentor variabilis KW - Ixodes pacificus KW - cell lines KW - Z 05161:Cell & tissue culture KW - J 02870:Invertebrate bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14664203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Microbiology&rft.atitle=Arthropod+cell+lines+in+the+isolation+and+propagation+of+tickborne+spiroplasmas.&rft.au=Yunker%2C+CE%3BTully%2C+J+G%3BCory%2C+J&rft.aulast=Yunker&rft.aufirst=CE&rft.date=1987-01-01&rft.volume=15&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Current+Microbiology&rft.issn=03438651&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Spiroplasma; Ixodes pacificus; Dermacentor variabilis; Ixodidae; cell lines ER - TY - JOUR T1 - MPP super(+) (1-methyl-4-phenylpyridine) is a neurotoxin to dopamine-, norpinephrine- and serotonin-containing neurons. AN - 14658651; 1526088 AB - 1-Methyl-4-phenylpyridine (MPP super(+)) is an oxidative metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP). MPP super(+) produced local cell death when injected directly into substantia nigra compacta, locus coeruleus, or dorsal and median raphe nuclei of rats. Corresponding significant decreases in dopamine, serotonin and norepinephrine levels were observed in the terminal areas. These observations indicate that MPP super(+) is a non-selective neurotoxin which causes lesions not only in dopaminergic neurons but also in noradrenergic and serotonergic systems following intracranial administration. Selective lesioning of these monoaminergic systems could only be achieved by a stereotaxic injection of MPP super(+) into specific brain regions containing monoamine neurons. JF - European Journal of Pharmacology AU - Namura, I AU - Douillet, P AU - Sun, C J AU - Pert, A AU - Cohen, R M AU - Chiueh, C C AD - LCM, NIMH, Build. 10, Rm. 2D52, NIH, Bethesda, MD 20892-1000, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 31 EP - 37 VL - 136 IS - 1 SN - 0014-2999, 0014-2999 KW - effects on KW - containing KW - rats KW - MPP super(+) KW - monoamines KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - locus coeruleus KW - raphe nuclei KW - neurotoxicity KW - substantia nigra KW - neurons KW - N3 11104:Mammals (except primates) KW - X 24115:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14658651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Pharmacology&rft.atitle=MPP+super%28%2B%29+%281-methyl-4-phenylpyridine%29+is+a+neurotoxin+to+dopamine-%2C+norpinephrine-+and+serotonin-containing+neurons.&rft.au=Namura%2C+I%3BDouillet%2C+P%3BSun%2C+C+J%3BPert%2C+A%3BCohen%2C+R+M%3BChiueh%2C+C+C&rft.aulast=Namura&rft.aufirst=I&rft.date=1987-01-01&rft.volume=136&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - neurotoxicity; neurons; substantia nigra; raphe nuclei; locus coeruleus ER - TY - JOUR T1 - Specific Vinca alkaloid-binding polypeptides identified in calf brain by photoaffinity labeling. AN - 14650720; 1521148 AB - A radioactive, photoactive Vinca alkaloid, N-(pazido-(3,5- super(3)H)-benzoyl)-N'- beta -aminoethylvindesine (( super(3)H)NABV) with pharmacological and biological activities similar to vinblastine was synthesized and used to identify specific Vinca) alkaloid macromolecular interactions in calf brain homogenate by photoaffinity labeling. The most prominent photolabeled species were 54.3- and 21.5-kDa polypeptides. The Vinca alkaloid-binding specificity of these polypeptides was confirmed by competitive blocking of specific photolabeling by vinblastine but not by colchicine or daunorubicin. The results demonstrate that ( super(3)H)NABV is an attractive tool for identifying and characterizing specific high affinity vinblastine cellular polypeptide acceptors which may initiate or mediate known and unknown mechanisms of Vinca) alkaloid action. JF - Journal of Biological Chemistry AU - Safa, A R AU - Felsted, RL AD - NCI, NIH, Build. 37, Rm. 5D02, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 1261 EP - 1267 VL - 262 IS - 3 SN - 0021-9258, 0021-9258 KW - N-(p-azido-3,5-benzoyl)-N'- beta -aminoethylvindesine KW - binding KW - brain KW - cattle KW - characterization KW - photoaffinity labelling KW - proteins KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 1: Biological Membranes (till 1993); CSA Neurosciences Abstracts KW - N3 11070:Neurochemistry and cellular biology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14650720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Specific+Vinca+alkaloid-binding+polypeptides+identified+in+calf+brain+by+photoaffinity+labeling.&rft.au=Safa%2C+A+R%3BFelsted%2C+RL&rft.aulast=Safa&rft.aufirst=A&rft.date=1987-01-01&rft.volume=262&rft.issue=3&rft.spage=1261&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - photoaffinity labelling; brain; proteins ER - TY - JOUR T1 - Associations between smoking and body weight in the US population: Analysis of NHANES II. AN - 14639859; 1505610 AB - Recent recommendations for increases in desirable body weights are based upon studies which did not consider the potential confounding effect of cigarette consumption on body weight. The authors investigated the relation between tobacco use and several anthropometric measurements in 12,103 men and women 19-74 years of age in the United States examined between 1976 and 1980 during the Second National Health and Nutrition Examination Survey (NHANES II). Cigarette smokers weighed less and were leaner than nonsmokers, controlling for age and sex. Body leanness increased with the duration (but not intensity) of smoking. Ex-smokers were not heavier or fatter than nonsmokers, and these groups experienced similar weight gain after age 25, while current smokers gained substantially less weight. Compared to nonsmokers, former and current smokers were also slightly taller. JF - American Journal of Public Health AU - Albanes, D AU - Jones, D Y AU - Micozzi AU - Mattson, ME AD - Cancer Prev. Stud. Branch, Blair Build., Rm. 6A09, NCI, NIH, Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 439 EP - 444 VL - 77 IS - 4 SN - 0090-0036, 0090-0036 KW - relationship KW - body weight KW - populations KW - man KW - cigarette KW - weight KW - United States KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - epidemiology KW - USA KW - smoking KW - H SE4.26:DRUGS AND ALCOHOL KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14639859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Associations+between+smoking+and+body+weight+in+the+US+population%3A+Analysis+of+NHANES+II.&rft.au=Albanes%2C+D%3BJones%2C+D+Y%3BMicozzi%3BMattson%2C+ME&rft.aulast=Albanes&rft.aufirst=D&rft.date=1987-01-01&rft.volume=77&rft.issue=4&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - USA; smoking; epidemiology; body weight; populations; man; weight ER - TY - JOUR T1 - Smoking, physical activity, and other predictors of endurance and heart rate response to exercise in asymptomatic hypercholesterolemic men. The lipid research clinics coronary primary prevention trial. AN - 14638815; 1505667 AB - The association of known coronary risk factors with progressive submaximal treadmill exercise tolerance test performance was studied in 6,238 asymptomatic white 34-60-year-old hypercholesterolemic men screened between 1973 and 1976 for the Lipid Research Clinics Coronary Primary Prevention Trial. Cigarette smoking and habitual physical inactivity were each associated with a doubling of the rate of symptom-related discontinuation of the exercise test; the tests of sedentary smokers were discontinued at four times the rate observed for active nonsmokers. Smaller increases in heart rate were observed during exercise testing in physically active men and in smokers than in their sedentary and nonsmoking counterparts. Thus, smoking, like habitual physical activity, reduced the heart rate required to sustain a given external workload. However, the heart rates of smokers tended to remain elevated after exercise, while those of physically active men returned more rapidly toward resting levels. JF - American Journal of Epidemiology AU - Gordon, D J AU - Leon, A S AU - Ekelund, L-G AU - Sopko, G AU - Probstfield, J L AU - Rubenstein, C AU - Sheffield, L T AD - Lipid Metab. Atherogenesis Branch, DHVD, NHLBI, Natl. Inst. Health, Rm. 401, Fed. Build., Bethesda, MD 20892, USA Y1 - 1987 PY - 1987 DA - 1987 SP - 587 EP - 600 VL - 125 IS - 4 SN - 0002-9262, 0002-9262 KW - cholesterol KW - Toxicology Abstracts KW - heart rate KW - blood pressure KW - physical training KW - smoking KW - hypercholesterolemia KW - man KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14638815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Smoking%2C+physical+activity%2C+and+other+predictors+of+endurance+and+heart+rate+response+to+exercise+in+asymptomatic+hypercholesterolemic+men.+The+lipid+research+clinics+coronary+primary+prevention+trial.&rft.au=Gordon%2C+D+J%3BLeon%2C+A+S%3BEkelund%2C+L-G%3BSopko%2C+G%3BProbstfield%2C+J+L%3BRubenstein%2C+C%3BSheffield%2C+L+T&rft.aulast=Gordon&rft.aufirst=D&rft.date=1987-01-01&rft.volume=125&rft.issue=4&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - smoking; physical training; blood pressure; heart rate; hypercholesterolemia; man ER - TY - JOUR T1 - On the prediction of soil sorption coefficients of organic pollutants from molecular structure: application of molecular topology model AN - 13805125; 198703277 AB - Tests demonstrated that the range of applicability of a simple non-empirical model based on the topological properties of organic molecules could be extended to predict the soil sorption characteristics for chlorobenzenes, PAH, alkylbenzenes, heterocyclic and substituted PAH, halogenated alkanes and alkenes and halogenated phenols. The model was more accurate, faster and had a greater range of applicability than empirical models based on 1-octanol/water partition coefficients or water. Further tests on approximately 160 polar and ionic compounds showed that the topological model and a semi-empirical variable could predict the soil sorption properties of nearly 95 per cent of all organic chemicals with known soil sorption coefficients, and could therefore be used to produce priority lists for testing potentially hazardous chemicals. A bibliography of 55 references is provided. JF - Environmental Science & Technology AU - Sabljic, A AD - National Institutes of Health, Bethesda, Md. Y1 - 1987 PY - 1987 DA - 1987 SP - 358 EP - 366 VL - 21 IS - 4 SN - 0013-936X, 0013-936X KW - Hazard KW - Modelling (-general-) KW - Pollution (s/a contamination, individ grps below) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13805125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=On+the+prediction+of+soil+sorption+coefficients+of+organic+pollutants+from+molecular+structure%3A+application+of+molecular+topology+model&rft.au=Sabljic%2C+A&rft.aulast=Sabljic&rft.aufirst=A&rft.date=1987-01-01&rft.volume=21&rft.issue=4&rft.spage=358&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Alteration of the Redox State of Nadph and Glutathione in Perfused Rabbit Lung By Paraquat AN - 760214964; 13623451 AB - The glutathione and NADP + status of perfused rabbit lung was deter mined both before and after perfusion with 1 mM paraquat. The pul monary glutathione redox state was similar to that of liver, having a glutathione/glutathione disulfide ratio of about 240. This ratio was lower in lungs perfused with glucose-free medium, a condition in which NADPH probably becomes limiting. Perfusion with paraquat signifi cantly increased the pulmonary glutathione disulfide content, particu larly in the absence of glucose, resulting in a glutathionelglutathione disulfide ratio of <100. NADP+ levels in rabbit lung were increased approximately two-fold by perfusion with paraquat in medium con taining glucose and three-fold in the absence of glucose. JF - Toxicology and Industrial Health AU - Brigelius, Regina AU - Dostal, Lori A AU - Horton, Julie K AU - Bend, John R AD - Laboratory of Pharmacology National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park, North Carolina Y1 - 1986/12// PY - 1986 DA - Dec 1986 SP - 417 EP - 428 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 2 IS - 4 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts KW - Redox properties KW - Perfusion KW - Glutathione KW - Lung KW - Glucose KW - Liver KW - Paraquat KW - NADP KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760214964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Alteration+of+the+Redox+State+of+Nadph+and+Glutathione+in+Perfused+Rabbit+Lung+By+Paraquat&rft.au=Brigelius%2C+Regina%3BDostal%2C+Lori+A%3BHorton%2C+Julie+K%3BBend%2C+John+R&rft.aulast=Brigelius&rft.aufirst=Regina&rft.date=1986-12-01&rft.volume=2&rft.issue=4&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F074823378600200405 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 34 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Redox properties; Perfusion; Lung; Glutathione; Liver; Glucose; Paraquat; NADP DO - http://dx.doi.org/10.1177/074823378600200405 ER - TY - JOUR T1 - Set of novel, conserved proteins fold pre-messenger RNA into ribonucleosomes. AN - 77351885; 3329728 JF - Proteins AU - Chung, S Y AU - Wooley, J AD - Lab of Experimental Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1986/11// PY - 1986 DA - November 1986 SP - 195 EP - 210 VL - 1 IS - 3 SN - 0887-3585, 0887-3585 KW - Heterogeneous-Nuclear Ribonucleoproteins KW - 0 KW - Nucleoproteins KW - Nucleosomes KW - RNA Precursors KW - Ribonucleoproteins KW - Index Medicus KW - Animals KW - RNA Splicing KW - Humans KW - Molecular Sequence Data KW - Ribonucleoproteins -- metabolism KW - Ribonucleoproteins -- genetics KW - Amino Acid Sequence KW - Nucleic Acid Conformation KW - RNA Precursors -- metabolism KW - Nucleosomes -- metabolism KW - Nucleoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77351885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins&rft.atitle=Set+of+novel%2C+conserved+proteins+fold+pre-messenger+RNA+into+ribonucleosomes.&rft.au=Chung%2C+S+Y%3BWooley%2C+J&rft.aulast=Chung&rft.aufirst=S&rft.date=1986-11-01&rft.volume=1&rft.issue=3&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Proteins&rft.issn=08873585&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-20 N1 - Date created - 1988-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Olfactory evoked potentials in the rat. AN - 85183323; pmid-3762286 AB - Routine clinical assessment of the integrity of the olfactory pathway using olfactory evoked potentials remains an elusive goal. One important difficulty arises from the uncertainty of the exact origin of the potentials: are they produced by olfactory or trigeminal elements? To resolve this problem, an animal model using the rat was developed. Amylacetate was used as an odorant stimulus, and potentials were measured and computer averaged after elimination of trigeminal and vomeronasal activity. A positive-negative wave was recorded from the olfactory bulb surface, and a negative wave often followed by a positive wave was recorded from the surface of the cerebral cortex. Measurements from the scalp surface gave comparable results. Lesioning experiments of the olfactory pathway indicate that the evoked potentials recorded at the vertex originate in the ventral forebrain, specifically in the prepyriform cortex, olfactory tubercle, and anterior olfactory nucleus. JF - The Laryngoscope AU - Inokuchi, A AU - Kimmelman, C P AU - Wang, H E AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1986 SP - 1107 EP - 1111 VL - 96 IS - 10 SN - 0023-852X, 0023-852X KW - Rats, Inbred Strains KW - Rats KW - Frontal Lobe KW - Cerebral Cortex KW - Support, U.S. Gov't, P.H.S. KW - Olfactory Pathways KW - Evoked Potentials KW - Pentanols KW - Animal KW - Olfactory Bulb KW - Central Nervous System KW - Male KW - Reaction Time KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85183323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Olfactory+evoked+potentials+in+the+rat.&rft.au=Inokuchi%2C+A%3BKimmelman%2C+C+P%3BWang%2C+H+E%3BSnow%2C+J+B&rft.aulast=Inokuchi&rft.aufirst=A&rft.date=1986-10-01&rft.volume=96&rft.issue=10&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The Accumulation of Pyrophosphate By Rat Hepatocytes AN - 760214883; 13623445 AB - Hepatocytes that were isolated from 48 hr starved rats and incu bated in Krebs-Henseleit bicarbonate buffer containing 10 kM A23187, 10mM l-lactate, 1 mM pyruvate and 2mM l-lysine were found to contain 0.064 kmol of inorganic pyrophosphate/g wet wgt cells. Addition of either 20mM acetate or butyrate, which caused the formation of pyrophosphate in both the cytosol and the mitochondrial matrix or only the matrix, resulted in an increase of 0.915 and 1.91 kmol pyrophosphate/g wet wgt cells, respectively. The accumulation of pyrophosphate was shown to be non-linear with time and dependent on the calcium concentration of the incu bation media. In contrast, incubations containing a combination of 10 mM NH sub(4) Cl and 5 mM ornithine, which resulted in the forma tion of pyrophosphate only in the cytosol, had a pyrophosphate content of 0.032 kmol/g wgt cells. When isolated hepatocytes that had been incubated with acetate or butyrate were subjected to dig itonin fractionation, all of the recoverable pyrophosphate was pres ent in the particulate fraction. It is concluded that pyrophosphate accumulates in isolated rat hepatocytes only in the presence of cal cium and a calcium ionophore, only within the mitochondrial matrix and only when pyrophosphate is formed within the mito chondrial matrix. JF - Toxicology and Industrial Health AU - Gitomer, William L AU - Veech, Richard L AD - Laboratory of Metabolism National Institute on Alcohol Abuse and Alcoholism Rockville, Maryland Y1 - 1986/09// PY - 1986 DA - Sep 1986 SP - 299 EP - 307 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 2 IS - 3 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts KW - 2. Key words: mitochondria KW - pyrophosphate KW - rat hepatocytes KW - short-chain fatty acids. KW - Pyruvic acid KW - calcium ionophores KW - Hepatocytes KW - Calcimycin KW - L-lysine KW - Cytosol KW - Mitochondria KW - ornithine KW - Bicarbonate KW - Acetic acid KW - pyrophosphates KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760214883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=The+Accumulation+of+Pyrophosphate+By+Rat+Hepatocytes&rft.au=Gitomer%2C+William+L%3BVeech%2C+Richard+L&rft.aulast=Gitomer&rft.aufirst=William&rft.date=1986-09-01&rft.volume=2&rft.issue=3&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F074823378600200308 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 30 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - calcium ionophores; Pyruvic acid; Hepatocytes; L-lysine; Calcimycin; Cytosol; ornithine; Mitochondria; Bicarbonate; Acetic acid; pyrophosphates DO - http://dx.doi.org/10.1177/074823378600200308 ER - TY - JOUR T1 - Review : Polynucleotides as Interferon Inducers and Immune Modulators AN - 21208363; 11612534 AB - Abstract not available. JF - Journal of Bioactive and Compatible Polymers AU - Levy, Hilton B AD - National Institutes of Health Bethesda, Maryland Y1 - 1986/07// PY - 1986 DA - Jul 1986 SP - 348 EP - 385 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 1 IS - 3 SN - 0883-9115, 0883-9115 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Interferon KW - Reviews KW - polynucleotides KW - Immunomodulation KW - W 30910:Imaging KW - F 06960:Molecular Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21208363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bioactive+and+Compatible+Polymers&rft.atitle=Review+%3A+Polynucleotides+as+Interferon+Inducers+and+Immune+Modulators&rft.au=Levy%2C+Hilton+B&rft.aulast=Levy&rft.aufirst=Hilton&rft.date=1986-07-01&rft.volume=1&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bioactive+and+Compatible+Polymers&rft.issn=08839115&rft_id=info:doi/10.1177%2F088391158600100306 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Interferon; Reviews; polynucleotides; Immunomodulation DO - http://dx.doi.org/10.1177/088391158600100306 ER - TY - JOUR T1 - Induction of cytochrome P-450 isozymes by hexachlorobenzene in rats and aromatic hydrocarbon (Ah)-responsive mice. AN - 77415155; 2856071 AB - Hexachlorobenzene (HCB) differs markedly from other chlorinated benzenes (CBs) as an inducer of cytochrome P-450 (P-450) isozymes as determined by radioimmunoassay and immunoblotting. At greater than 99% pure, HCB induced both the phenobarbital-inducible forms, cytochromes P-450b + e (70 chi), and the 3-methylcholanthrene-inducible forms, cytochromes P-450c (58 chi) and P-450d (8 chi), in rat liver microsomes. The concentration of P-450d was considerably greater than that of P-450c in HCB-induced rat liver. In contrast to HCB, all lower chlorinated benzenes tested were PB-type inducers. Hexachlorobenzene increased the amounts of translatable messenger RNAs (mRNAs) for P-450b, P-450c, and P-450d in rat liver polysomes, suggesting that it increases the synthesis of these proteins. Evidence that HCB interacted with the putative Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was equivocal. Western blots of liver microsomes from Ah-responsive C57BL/6J (B6) and nonresponsive DBA/2J (D2) mice demonstrated that HCB produced a large increase in P3-450 and a very small increase in P1-450 in the responsive strain. The increase in P1-450 was not observed after HCB administration to nonresponsive mice, but a small increase in P3-450 was noted. These findings suggested that HCB may act through the Ah receptor. However, HCB was at best a very weak competitor for specific binding of [3H]-TCDD to the putative receptor in rat or mouse hepatic cytosol in vitro, producing decreases in binding of [3H]-TCDD only at very high concentrations (10(-6) to 10(-5) M). JF - Journal of biochemical toxicology AU - Linko, P AU - Yeowell, H N AU - Gasiewicz, T A AU - Goldstein, J A AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. Y1 - 1986/06// PY - 1986 DA - June 1986 SP - 95 EP - 107 VL - 1 IS - 2 SN - 0887-2082, 0887-2082 KW - Chlorobenzenes KW - 0 KW - Isoenzymes KW - Polychlorinated Dibenzodioxins KW - RNA, Messenger KW - Receptors, Aryl Hydrocarbon KW - Receptors, Drug KW - Hexachlorobenzene KW - 4Z87H0LKUY KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Liver -- enzymology KW - Mice KW - Polyribosomes -- metabolism KW - Polychlorinated Dibenzodioxins -- metabolism KW - Mice, Inbred DBA KW - Rats, Inbred Strains KW - Rats KW - Protein Biosynthesis -- drug effects KW - RNA, Messenger -- metabolism KW - Enzyme Induction -- drug effects KW - Liver -- drug effects KW - Binding Sites -- drug effects KW - Polyribosomes -- enzymology KW - Mice, Inbred C3H KW - Mice, Inbred C57BL KW - Receptors, Drug -- genetics KW - Chlorobenzenes -- toxicity KW - Receptors, Drug -- metabolism KW - Hexachlorobenzene -- analysis KW - Receptors, Drug -- drug effects KW - Cytochrome P-450 Enzyme System -- genetics KW - Cytochrome P-450 Enzyme System -- metabolism KW - Isoenzymes -- metabolism KW - Hexachlorobenzene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77415155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biochemical+toxicology&rft.atitle=Induction+of+cytochrome+P-450+isozymes+by+hexachlorobenzene+in+rats+and+aromatic+hydrocarbon+%28Ah%29-responsive+mice.&rft.au=Linko%2C+P%3BYeowell%2C+H+N%3BGasiewicz%2C+T+A%3BGoldstein%2C+J+A&rft.aulast=Linko&rft.aufirst=P&rft.date=1986-06-01&rft.volume=1&rft.issue=2&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Journal+of+biochemical+toxicology&rft.issn=08872082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-20 N1 - Date created - 1990-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The murine aromatic hydrocarbon responsiveness locus: a comparison of receptor levels and several inducible enzyme activities among recombinant inbred lines. AN - 77419700; 2856069 AB - The aromatic hydrocarbon responsiveness (Ah) locus has been correlated with genetic differences in the risk of drug toxicity, teratogenesis, chemical carcinogenesis, and mutagenesis. Hepatic cytosolic Ah receptor levels, 2-amino-5-chlorobenzoxazole (zoxazolamine) paralysis time following beta-naphthoflavone treatment and aryl hydrocarbon hydroxylase (AHH3, acetanilide 4-hydroxylase (Ac4H), and NAD(P)H:menadione oxidoreductase (NMOR)4, induction by 3-methylcholanthrene were studied in (a) the progenitors C57BL/6J (Ahb/Ahb) and DBA/2J (Ahd/Ahd) and 25 BXD recombinant inbred lines, (b) the progenitors C57BL/6N and C3H/HeN and 14 B6NXC3N recombinant inbred lines, and (c) the progenitors C57BL/6J and C3H/HeJ and 12 BXH recombinant inbred lines. The Ahb phenotype exhibits greater than 5 femtomole receptor/mg of cytosolic protein, less than or equal to 15 minutes zoxazolamine paralysis time, and twofold to 15-fold induction of these three hepatic enzyme activities; the Ahd phenotype exhibits less than or equal to 2 fmol receptor/mg protein, greater than 15 minutes zoxazolamine paralysis time, and less than 30% induction of these three activities. Among the BXD lines but especially among the B6NXC3N and BXH lines, high frequencies of recombination were found; the phenotype of each of the five parameters did not segregate with the phenotype of each of the other parameters in four or more recombinant lines. This report shows for the first time that AHH induction by 3-methylcholanthrene can occur in the Ahd phenotype mouse. These data underline the complexity of this genetic system when genes from C57BL/6 and DBA/2 are combined and particularly when genes from C57BL/6 and C3H/He inbred mouse strains are combined. JF - Journal of biochemical toxicology AU - Bigelow, S W AU - Nebert, D W AD - Laboratory of Developmental Pharmacology, National Institute of Child Health and Human Development, Bethesda, Md. Y1 - 1986/03// PY - 1986 DA - March 1986 SP - 1 EP - 14 VL - 1 IS - 1 SN - 0887-2082, 0887-2082 KW - Benz(a)Anthracenes KW - 0 KW - Benzoflavones KW - Polychlorinated Dibenzodioxins KW - Receptors, Aryl Hydrocarbon KW - Receptors, Drug KW - Methylcholanthrene KW - 56-49-5 KW - beta-Naphthoflavone KW - 6051-87-2 KW - Zoxazolamine KW - 9DOW362Q29 KW - benz(a)anthracene KW - C5PLF6152K KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - acetanilide hydroxylase KW - Quinone Reductases KW - EC 1.6.99.- KW - Index Medicus KW - Mice, Inbred DBA -- genetics KW - Animals KW - Mice, Inbred C57BL -- genetics KW - Polychlorinated Dibenzodioxins -- pharmacology KW - Zoxazolamine -- pharmacology KW - Quinone Reductases -- genetics KW - Mice KW - Benz(a)Anthracenes -- pharmacology KW - Methylcholanthrene -- pharmacology KW - Mice, Inbred C3H -- genetics KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Male KW - Benzoflavones -- pharmacology KW - Receptors, Drug -- genetics KW - Enzyme Induction -- drug effects KW - Mice, Inbred Strains -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77419700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biochemical+toxicology&rft.atitle=The+murine+aromatic+hydrocarbon+responsiveness+locus%3A+a+comparison+of+receptor+levels+and+several+inducible+enzyme+activities+among+recombinant+inbred+lines.&rft.au=Bigelow%2C+S+W%3BNebert%2C+D+W&rft.aulast=Bigelow&rft.aufirst=S&rft.date=1986-03-01&rft.volume=1&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+biochemical+toxicology&rft.issn=08872082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-20 N1 - Date created - 1990-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The tolerance of skin grafts to postoperative radiation therapy in patients with soft-tissue sarcoma. AN - 77419199; 3273036 AB - During the last ten years at the National Cancer Institute, 11 patients have received 12 courses of postoperative adjuvant radiation therapy to skin grafts used for wound closure after the resection of soft-tissue sarcomas. The intervals between grafting and the initiation of radiation ranged between 3 and 20 weeks, and 4 patients received chemotherapy at the same time as their radiation. Ten of the 12 irradiated grafts remained intact after the completion of therapy. One graft had several small persistently ulcerated areas that required no further surgical treatment, and one graft required a musculocutaneous flap for reconstruction of a persistent large ulcer. Acute radiation effects on the grafted skin sometimes developed at slightly lower doses than usually seen with normal skin, but these acute effects necessitated a break in therapy on only five occasions. Concurrent chemotherapy and a relatively short interval between grafting and the initiation of radiation seemed to contribute to more severe radiation reactions. This experience indicates that postoperative adjuvant radiation therapy can be delivered to skin grafted areas without undue fear of complications, especially if the graft is allowed to heal adequately prior to initiating therapy and if chemotherapy is not given in conjunction with radiation. JF - Annals of plastic surgery AU - Lawrence, W T AU - Zabell, A AU - McDonald, H D AD - Surgery Branch, National Cancer Institute, Bethesda, MD 20205. Y1 - 1986/03// PY - 1986 DA - March 1986 SP - 204 EP - 210 VL - 16 IS - 3 SN - 0148-7043, 0148-7043 KW - Index Medicus KW - Combined Modality Therapy KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Reoperation KW - Radiation Tolerance KW - Incidence KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Soft Tissue Neoplasms -- therapy KW - Skin Transplantation KW - Radiation Injuries -- epidemiology KW - Radiation Injuries -- surgery KW - Sarcoma -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77419199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+plastic+surgery&rft.atitle=The+tolerance+of+skin+grafts+to+postoperative+radiation+therapy+in+patients+with+soft-tissue+sarcoma.&rft.au=Lawrence%2C+W+T%3BZabell%2C+A%3BMcDonald%2C+H+D&rft.aulast=Lawrence&rft.aufirst=W&rft.date=1986-03-01&rft.volume=16&rft.issue=3&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Annals+of+plastic+surgery&rft.issn=01487043&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-19 N1 - Date created - 1990-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The prevalence of serological markers to hepatitis A and hepatitis B in drug abuse personnel. AN - 77357766; 2839211 AB - A seroepidemiologic survey was conducted in 25 clinical and 31 nonclinical personnel engaged in substance abuse research and treatment. The antibody to hepatitis A virus (anti-HAV) was identified in 16 percent of the clinical employees and 39 percent of the nonclinical personnel, for a total prevalence of 29 percent. The prevalence of anti-HAV was age related, and the overall frequency was not greater than expected attack rates. Hepatitis B virus (HBV) markers were present in 16 percent of the clinical personnel tested but in only 3 percent of nonclinical personnel, for a total prevalence of 9 percent among the two groups. The nonclinical risk did not exceed the background prevalence of the disease, but the risk for clinical employees was three to five times greater. This risk appeared to be associated with exposure to blood and other potentially infectious body fluids; however, in no case could an employee with HBV markers recall a percutaneous injury, and covert means of transmission could not be excluded. Only one case (20 percent) of HBV infection manifested clinical symptomatology. Even though proper environmental safety measures may decrease the incidence of HBV infection in at-risk groups, some health care workers and researchers in the field of substance abuse may be at sufficiently increased risk of HBV infection to warrant immunization with hepatitis B vaccine. JF - American journal of preventive medicine AU - Lange, W R AU - Moore, J D AU - Kreider, S D AD - Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224. PY - 1986 SP - 109 EP - 115 VL - 2 IS - 2 SN - 0749-3797, 0749-3797 KW - Hepatitis Antibodies KW - 0 KW - Hepatitis B Surface Antigens KW - Index Medicus KW - Cross-Sectional Studies KW - Age Factors KW - Hepatitis B virus -- immunology KW - Hepatitis B Surface Antigens -- analysis KW - Risk Factors KW - Humans KW - Hepatovirus -- immunology KW - Male KW - Female KW - Substance-Related Disorders -- microbiology KW - Hepatitis Antibodies -- immunology KW - Hepatitis, Viral, Human -- transmission KW - Health Manpower UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77357766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+preventive+medicine&rft.atitle=The+prevalence+of+serological+markers+to+hepatitis+A+and+hepatitis+B+in+drug+abuse+personnel.&rft.au=Lange%2C+W+R%3BMoore%2C+J+D%3BKreider%2C+S+D&rft.aulast=Lange&rft.aufirst=W&rft.date=1986-03-01&rft.volume=2&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=American+journal+of+preventive+medicine&rft.issn=07493797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-23 N1 - Date created - 1988-08-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Use and misuse of epidemiologic data in the courtroom: defining the limits of inferential and particularistic evidence in mass tort litigation. AN - 77360035; 3451678 AB - Medical epidemiology is the cornerstone for understanding the safety and efficacy of drugs and medical devices. Epidemiologic principles provide a statistical basis for determining correlations, and ultimately mathematical causation, between two series of events. Medical epidemiologic evidence and statistical inferences are useful and are now routinely accepted in the courtroom. The complex distribution systems that provide fungible goods throughout the country often preclude the identification of the specific source of an allegedly defective product. An expansion of the principles established in Summers v. Tice and Ybarra v. Spangard provide a logical and rational means for the courts to address products liability issues in cases involving multiple and unnamed defendants. This Article discusses the impact of epidemiology on the judicial process, both in the nature of judicial decision-making and in the nature of the law itself. Part III B discusses the "weak" and "strong" versions of the traditional preponderance of the evidence rule, as recast by recent products liability litigation. The remainder of the Article defines the useful and appropriate scope of epidemiologic evidence, concluding that "intentless" epidemiologic evidence alone cannot support an award of punitive damages. JF - American journal of law & medicine AU - Ginzburg, H M AD - Epidemiology Branch, National Institute of Allergy and Infectious Diseases' AIDS Program. Y1 - 1986 PY - 1986 DA - 1986 SP - 423 EP - 439 VL - 12 IS - 3-4 SN - 0098-8588, 0098-8588 KW - Influenza Vaccines KW - 0 KW - Polychlorinated Dibenzodioxins KW - 2,4-Dichlorophenoxyacetic Acid KW - 2577AQ9262 KW - Agent Orange KW - 39277-47-9 KW - 2,4,5-Trichlorophenoxyacetic Acid KW - 9Q963S4YMX KW - Benzene KW - J64922108F KW - Paraquat KW - PLG39H7695 KW - Index Medicus KW - United States KW - Paraquat -- adverse effects KW - 2,4-Dichlorophenoxyacetic Acid -- adverse effects KW - 2,4,5-Trichlorophenoxyacetic Acid -- adverse effects KW - Polychlorinated Dibenzodioxins -- adverse effects KW - Humans KW - Environmental Exposure KW - Influenza Vaccines -- adverse effects KW - Benzene -- adverse effects KW - Epidemiologic Methods KW - Jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77360035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+law+%26+medicine&rft.atitle=Use+and+misuse+of+epidemiologic+data+in+the+courtroom%3A+defining+the+limits+of+inferential+and+particularistic+evidence+in+mass+tort+litigation.&rft.au=Ginzburg%2C+H+M&rft.aulast=Ginzburg&rft.aufirst=H&rft.date=1986-01-01&rft.volume=12&rft.issue=3-4&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=American+journal+of+law+%26+medicine&rft.issn=00988588&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-08 N1 - Date created - 1988-07-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Structure and function of p21 ras proteins. AN - 77354810; 3333361 AB - Cancer is a malfunction of cellular growth control. The discovery of oncogenes, first in transforming retroviruses, and later in human and animal tumors, may have uncovered the key to understanding one of the most elusive subjects of basic cell biology, namely, the controlling mechanisms of cell growth. The ras gene family encodes a group of closely related 21,000 dalton (p21) proteins with special affinity for guanine nucleotides. Other cellular proteins with similar biochemical properties, collectively known as G-proteins, include the regulatory G proteins of adenylate cyclase, the alpha subunit of transducin of retina rod outer segments, the recently identified rho gene proteins, and perhaps also the elongation factors, EF-Tu and EF-G, of the protein synthesis system. These G-proteins have roles in cellular signal transduction; by analogy p21 may have a similar cellular function in mediating the flow of growth control signals. Recent progress in the cloning and sequencing of these genes, overproduction of gene products in E. coli, protein engineering, detailed biochemical characterization, and the molecular structure determined by high resolution X-ray crystallography, have helped to elucidate in great detail the structure and function of p21 ras proteins. p21 appears to have a small membrane binding domain at the C-terminus, which contains a palmitylation site at cysteine-186, four amino acid residues from the end. Separated by a variable "hinge" region, most of the rest of ras amino acid sequences are highly conserved in nature. Four regions of extensive sequence homology among G-proteins constitute the GTP/GDP binding domain. In the crystal structure of EF-Tu, four peptide loops connecting beta sheets and alpha helices form the pocket for binding GDP. Studies using site-directed mutagenesis and immnochemical probes, indicate that the basic structure of the GDP binding site is conserved between p21 and EF-Tu. Furthermore, these studies also conclude that GTP binding is crucial for p21 ras cellular function. Although the precise target molecules for p21 are still unknown, the finding of the on/off switch function for ras genes have provided a better understanding of the mechanism of proto-oncogene activation, and may also provide further impetus to explore means of cancer intervention by interfering with the switch function. JF - Gene amplification and analysis AU - Shih, T Y AU - Hattori, S AU - Clanton, D J AU - Ulsh, L S AU - Chen, Z Q AU - Lautenberger, J A AU - Papas, T S AD - Division of Cancer Etiology, National Cancer Institute, Frederick, MD 21701. Y1 - 1986 PY - 1986 DA - 1986 SP - 53 EP - 72 VL - 4 SN - 0275-2778, 0275-2778 KW - Membrane Proteins KW - 0 KW - Proto-Oncogene Proteins KW - Recombinant Fusion Proteins KW - Guanosine Triphosphate KW - 86-01-1 KW - HRAS protein, human KW - EC 3.6.5.2 KW - Proto-Oncogene Proteins p21(ras) KW - Index Medicus KW - Recombinant Fusion Proteins -- biosynthesis KW - Animals KW - Humans KW - Recombinant Fusion Proteins -- genetics KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Protein Conformation KW - Guanosine Triphosphate -- metabolism KW - Binding Sites KW - Genes, ras KW - Proto-Oncogene Proteins -- biosynthesis KW - Membrane Proteins -- ultrastructure KW - Proto-Oncogene Proteins -- ultrastructure KW - Membrane Proteins -- metabolism KW - Membrane Proteins -- biosynthesis KW - Proto-Oncogene Proteins -- metabolism KW - Proto-Oncogene Proteins -- physiology KW - Membrane Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77354810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+amplification+and+analysis&rft.atitle=Structure+and+function+of+p21+ras+proteins.&rft.au=Shih%2C+T+Y%3BHattori%2C+S%3BClanton%2C+D+J%3BUlsh%2C+L+S%3BChen%2C+Z+Q%3BLautenberger%2C+J+A%3BPapas%2C+T+S&rft.aulast=Shih&rft.aufirst=T&rft.date=1986-01-01&rft.volume=4&rft.issue=&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Gene+amplification+and+analysis&rft.issn=02752778&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-14 N1 - Date created - 1989-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Activation of ras oncogenes by chemical carcinogens. AN - 77354725; 2906037 JF - Gene amplification and analysis AU - Barbacid, M AU - Sukumar, S AU - Zarbl, H AD - Developmental Oncology Section, NCI-Frederick Cancer Research Facility, MD 21701. Y1 - 1986 PY - 1986 DA - 1986 SP - 21 EP - 38 VL - 4 SN - 0275-2778, 0275-2778 KW - Carcinogens KW - 0 KW - Codon KW - DNA, Neoplasm KW - Oligonucleotide Probes KW - Index Medicus KW - Rats KW - Oligonucleotide Probes -- chemical synthesis KW - Animals KW - Polymorphism, Restriction Fragment Length KW - Humans KW - DNA Mutational Analysis KW - Gene Expression Regulation KW - DNA, Neoplasm -- analysis KW - Female KW - Carcinogens -- pharmacology KW - Oncogenes KW - Mammary Neoplasms, Experimental -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77354725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+amplification+and+analysis&rft.atitle=Activation+of+ras+oncogenes+by+chemical+carcinogens.&rft.au=Barbacid%2C+M%3BSukumar%2C+S%3BZarbl%2C+H&rft.aulast=Barbacid&rft.aufirst=M&rft.date=1986-01-01&rft.volume=4&rft.issue=&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Gene+amplification+and+analysis&rft.issn=02752778&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-14 N1 - Date created - 1989-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of morphine and calcium antagonists on plasma glucose in male rats. AN - 77350414; 3123955 AB - Subcutaneous administration of morphine sulfate (4-16 mg/kg) did not significantly alter the plasma glucose concentration in fasted adult male Fischer-344 rats. All rats treated with calcium channel antagonists, verapamil or diltiazem (10 mg/kg, with or without morphine), showed marked and significant hyperglycemia, persisting at high levels throughout the 2 h experiment. JF - NIDA research monograph AU - Szikszay, M AU - Snyder, F R AU - London, E D AD - Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, Maryland 21224. Y1 - 1986 PY - 1986 DA - 1986 SP - 382 EP - 384 VL - 75 SN - 1046-9516, 1046-9516 KW - Blood Glucose KW - 0 KW - Morphine KW - 76I7G6D29C KW - Verapamil KW - CJ0O37KU29 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Drug Interactions KW - Kinetics KW - Male KW - Blood Glucose -- metabolism KW - Verapamil -- pharmacology KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77350414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Effects+of+morphine+and+calcium+antagonists+on+plasma+glucose+in+male+rats.&rft.au=Szikszay%2C+M%3BSnyder%2C+F+R%3BLondon%2C+E+D&rft.aulast=Szikszay&rft.aufirst=M&rft.date=1986-01-01&rft.volume=75&rft.issue=&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-18 N1 - Date created - 1988-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Regulated expression of calmodulin-dependent cyclic nucleotide phosphodiesterase in the central nervous system. AN - 77349770; 2831257 JF - Journal of cyclic nucleotide and protein phosphorylation research AU - Kincaid, R L AU - Balaban, C D AU - Billingsley, M L AD - Laboratory of Cellular Metabolism, National Institutes of Health, Bethesda, Maryland. PY - 1986 SP - 473 EP - 486 VL - 11 IS - 7 SN - 0746-3898, 0746-3898 KW - Calmodulin-Binding Proteins KW - 0 KW - Pyridines KW - 3-acetylpyridine KW - 00QT8FX306 KW - Calcineurin KW - EC 3.1.3.16 KW - Phosphoprotein Phosphatases KW - 3',5'-Cyclic-AMP Phosphodiesterases KW - EC 3.1.4.17 KW - Cyclic Nucleotide Phosphodiesterases, Type 1 KW - Index Medicus KW - Rats KW - Animals KW - Cattle KW - Calmodulin-Binding Proteins -- analysis KW - Purkinje Cells -- enzymology KW - Electrophoresis, Polyacrylamide Gel KW - Neurons -- enzymology KW - Phosphoprotein Phosphatases -- analysis KW - Tissue Distribution KW - Pyridines -- pharmacology KW - Immunoassay KW - 3',5'-Cyclic-AMP Phosphodiesterases -- analysis KW - Brain -- enzymology KW - Brain -- drug effects KW - Gene Expression Regulation KW - 3',5'-Cyclic-AMP Phosphodiesterases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77349770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cyclic+nucleotide+and+protein+phosphorylation+research&rft.atitle=Regulated+expression+of+calmodulin-dependent+cyclic+nucleotide+phosphodiesterase+in+the+central+nervous+system.&rft.au=Kincaid%2C+R+L%3BBalaban%2C+C+D%3BBillingsley%2C+M+L&rft.aulast=Kincaid&rft.aufirst=R&rft.date=1986-01-01&rft.volume=11&rft.issue=7&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Journal+of+cyclic+nucleotide+and+protein+phosphorylation+research&rft.issn=07463898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-18 N1 - Date created - 1988-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The human met oncogene is a member of the tyrosine kinase family. AN - 77348309; 3332011 AB - Prolonged exposure of a nontumorigenic human osteogenic sarcoma cell line (HOS) with the direct acting carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) gave rise to morphologically transformed cells which were tumorigenic in nude mice and termed MNNG-HOS. We have shown that DNA from MNNG-HOS cells will transform NIH/3T3 cells and have isolated greater than 35 kb of human DNA containing an oncogene, termed met. The activated met oncogene expresses a novel 5.0 kb RNA transcript which is a hybrid RNA derived from a DNA rearrangement involving two distinct genetic loci termed met and tpr (translocated promoter region). The met proto-oncogene has been localized to 7q21-q31 by in situ hybridization. This locus expresses a 9.0 kb RNA in fibroblast and epithelial cell lines, but is not commonly expressed in cell lines derived from the hematopoietic cell lineage. In contrast, the tpr locus is on chromosome 1, and expresses a 10.0 kb RNA in all human cell lines tested. The novel 5.0 kb met oncogene RNA is 3' co-terminal with the 9.0 kb met proto-oncogene RNA, while the 5' portion of this RNA uses at least two exons derived from the 10.0 kb tpr RNA. These exons are small and are presumably in the promoter region of both tpr and tpr-met transcripts. Nucleotide sequence analysis of the 3' end of met shows that it is a member of the tyrosine kinase family of genes. Peptide antibody to the C-terminal coding region of met immunoprecipitates a 65 kilodalton (kd) polypeptide (p65) in both MNNG-HOS cells and met transformed NIH/3T3 cells. This product also has tyrosine kinase activity in vitro and is presumed to correspond to the tpr-met product. The same antibody detects three larger met-related polypeptides of 160, 140, and 110 kd in human fibroblasts and epithelial cells by in vivo labeling with [35S]methionine. However, only one of the three met proto-oncogene polypeptides, p140, appears to be phosphorylated in the in vitro kinase assay. High levels of in vitro 32P incorporation into p140 met are observed in 4 out of 30 human epithelial cancer cell lines tested. Activation of the met oncogene in MNNG-HOS cells results from a DNA rearrangement possibly mediated in vitro by MNNG. The mode of activation of met may therefore be similar to the epidermal growth factor (EGF)R/v-erbB oncogene; or the bcr/c-abl rearrangement present in the Philadelphia chromosome translocation which is found in chronic myelogenous leukemias. JF - Princess Takamatsu symposia AU - Gonzatti-Haces, M AU - Park, M AU - Dean, M AU - Blair, D G AU - Vande Woude, G F AD - BRI-Basic Research Program, NCI-Frederick Cancer Research Facility, Maryland 21701. Y1 - 1986 PY - 1986 DA - 1986 SP - 221 EP - 232 VL - 17 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Index Medicus KW - Base Sequence KW - Humans KW - Molecular Sequence Data KW - Protein-Tyrosine Kinases -- genetics KW - Oncogenes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77348309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Princess+Takamatsu+symposia&rft.atitle=The+human+met+oncogene+is+a+member+of+the+tyrosine+kinase+family.&rft.au=Gonzatti-Haces%2C+M%3BPark%2C+M%3BDean%2C+M%3BBlair%2C+D+G%3BVande+Woude%2C+G+F&rft.aulast=Gonzatti-Haces&rft.aufirst=M&rft.date=1986-01-01&rft.volume=17&rft.issue=&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Princess+Takamatsu+symposia&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-27 N1 - Date created - 1988-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transformation by raf and myc oncogenes. AN - 77346195; 3332021 AB - raf oncogenes were shown to act synergistically with myc in transformation. The contribution of myc was identified as that of a "second messenger" in signal transduction of at least some, competence inducing, growth factors. The role of raf appears to be that of a cytosolic ser/thr specific protein kinase which was placed downstream of ras in the signal transduction of serum growth factors by ras and raf antibody microinjection experiments. Because of the inability of raf to abrogate a cells need for myc inducing competence factors, as well as its synergistic effect with myc, raf was placed downstream of ras in the progression pathway of cellular growth control. We speculate that the basis for synergism with myc might be the ability of raf to activate competence factor induced myc protein or a myc induced protein by phosphorylation. The role of raf in lung tumors was examined by the development of a high incidence mouse model system using ethylnitrosourea as carcinogen and butylated hydroxytoluene as promoter. raf proteins of normal size were expressed at high levels, raf protein vaccination was apparently effective in eliminating the promoted phase of tumor induction. JF - Princess Takamatsu symposia AU - Rapp, U R AU - Cleveland, J L AU - Storm, S M AU - Beck, T W AU - Huleihel, M AD - Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701. Y1 - 1986 PY - 1986 DA - 1986 SP - 55 EP - 74 VL - 17 KW - Index Medicus KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Oncogenes KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77346195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Princess+Takamatsu+symposia&rft.atitle=Transformation+by+raf+and+myc+oncogenes.&rft.au=Rapp%2C+U+R%3BCleveland%2C+J+L%3BStorm%2C+S+M%3BBeck%2C+T+W%3BHuleihel%2C+M&rft.aulast=Rapp&rft.aufirst=U&rft.date=1986-01-01&rft.volume=17&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Princess+Takamatsu+symposia&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-27 N1 - Date created - 1988-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neurobiology of behavioral control in drug abuse.Introduction. AN - 77338999; 3122049 JF - NIDA research monograph AU - Szara, S AD - National Institute on Drug Abuse Y1 - 1986 PY - 1986 DA - 1986 SP - 1 EP - 5 VL - 74 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - Humans KW - Research KW - Substance-Related Disorders -- psychology KW - Ego UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77338999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Neurobiology+of+behavioral+control+in+drug+abuse.Introduction.&rft.au=Szara%2C+S&rft.aulast=Szara&rft.aufirst=S&rft.date=1986-01-01&rft.volume=74&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-12 N1 - Date created - 1988-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Radioimmunodetection of melanoma: preliminary results of a prospective study. AN - 77336183; 2826619 AB - A prospective study to evaluate the clinical usefulness of radioimmunodetection of melanoma in clinical practice is ongoing at the National Cancer Institute of Milan, Italy. Technical conditions for the application of the method were previously reported. In this trial, 99mTc-labelled F(ab')2 fragments of the 225.28S monoclonal antibody were used against a high molecular weight melanoma associated antigen (HMW-MAA). Retrospective studies on radioimmunodetection of melanoma have already been made by our group and by other Centers in about 300 patients. This study concerns the evaluation of the regional extension of primary melanoma. 23 patients with 32 suspected lymphatic involvements of melanoma on the trunk and arms underwent immunoscintigraphy. No false positive results were observed; 3 false negatives, one corresponding to a micrometastasis, were noticed. Specificity corresponds to 100% and sensitivity to 78.6%. JF - The International journal of biological markers AU - Buraggi, G AU - Turrin, A AU - Cascinelli, N AU - Attili, A AU - Gasparini, M AU - Callegaro, L AU - Ferrone, S AU - Seregni, E AU - Bombardieri, E AU - Belli, F AD - Nuclear Medicine Division, National Cancer Institute of Milan, Italy. PY - 1986 SP - 47 EP - 54 VL - 1 IS - 1 SN - 0393-6155, 0393-6155 KW - Antibodies, Monoclonal KW - 0 KW - Immunoglobulin Fab Fragments KW - Sodium Pertechnetate Tc 99m KW - A0730CX801 KW - Index Medicus KW - Radiation Dosage KW - Humans KW - Adult KW - Skin Neoplasms -- diagnostic imaging KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Radionuclide Imaging KW - Melanoma -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77336183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+biological+markers&rft.atitle=Radioimmunodetection+of+melanoma%3A+preliminary+results+of+a+prospective+study.&rft.au=Buraggi%2C+G%3BTurrin%2C+A%3BCascinelli%2C+N%3BAttili%2C+A%3BGasparini%2C+M%3BCallegaro%2C+L%3BFerrone%2C+S%3BSeregni%2C+E%3BBombardieri%2C+E%3BBelli%2C+F&rft.aulast=Buraggi&rft.aufirst=G&rft.date=1986-01-01&rft.volume=1&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+biological+markers&rft.issn=03936155&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-25 N1 - Date created - 1988-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Control vs. lack of control over aversive stimuli: nonopioid-opioid analgesic consequences. AN - 77334017; 3122055 JF - NIDA research monograph AU - Drugan, R C AU - Maier, S F AD - Unit on Behavioral Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892. Y1 - 1986 PY - 1986 DA - 1986 SP - 71 EP - 89 VL - 74 SN - 1046-9516, 1046-9516 KW - Narcotics KW - 0 KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Index Medicus KW - Animals KW - Models, Psychological KW - Analgesia KW - Humans KW - gamma-Aminobutyric Acid -- physiology KW - Substance-Related Disorders -- psychology KW - Electroshock KW - Narcotics -- physiology KW - Internal-External Control KW - Stress, Psychological -- physiopathology KW - Stress, Psychological -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77334017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Control+vs.+lack+of+control+over+aversive+stimuli%3A+nonopioid-opioid+analgesic+consequences.&rft.au=Drugan%2C+R+C%3BMaier%2C+S+F&rft.aulast=Drugan&rft.aufirst=R&rft.date=1986-01-01&rft.volume=74&rft.issue=&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-12 N1 - Date created - 1988-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Role of oncogenes and tumor suppressor genes in a multistep model of carcinogenesis. AN - 77331724; 3321309 AB - We demonstrated previously that carcinogen-induced neoplastic transformation of Syrian hamster embryo (SHE) cells requires multiple steps. Normal, diploid SHE cells and carcinogen-induced preneoplastic cells were transfected with different oncogenes. The normal, early-passage cells were not transformed by the v-Ha-ras or v-myc oncogenes alone, but the two oncogenes combined caused tumors in nude mice and syngeneic hamsters. Cytogenetic analysis of the ras-plus-myc-induced tumors showed a nonrandom chromosome loss (monosomy of chromosome 15) in the ras/myc tumor cells. Tumorigenicity of the ras/myc tumor cells was suppressed following hybridization with normal SHE cells; reexpression of tumorigenicity at later passages correlated with loss of chromosome 15. The hybrid cells in which tumorigenicity was suppressed still expressed the ras and myc oncogenes. An early change in carcinogen-induced neoplastic progression of SHE cells is induction of immortality. At early passages, immortal cells retain the ability to suppress tumorigenicity in cell hybrids. This ability decreases with passaging of immortal cell lines. The susceptibility of immortal cell lines to neoplastic transformation by DNA transfection with the v-Ha-ras oncogene or tumor DNA inversely correlated with the tumor-suppressive ability of the cells in cell hybrids. These observations indicate that neoplastic transformation of SHE cells involves at least three steps: (1) induction of immortality, (2) activation of a transforming gene or oncogene, and (3) loss of or inactivation of a tumor-suppressor gene. JF - Symposium on Fundamental Cancer Research AU - Barrett, J C AU - Oshimura, M AU - Koi, M AD - Environmental Carcinogenesis Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Y1 - 1986 PY - 1986 DA - 1986 SP - 45 EP - 56 VL - 39 SN - 0190-1214, 0190-1214 KW - Index Medicus KW - Animals KW - Models, Genetic KW - Humans KW - Cell Transformation, Neoplastic KW - Oncogenes KW - Suppression, Genetic KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77331724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Symposium+on+Fundamental+Cancer+Research&rft.atitle=Role+of+oncogenes+and+tumor+suppressor+genes+in+a+multistep+model+of+carcinogenesis.&rft.au=Barrett%2C+J+C%3BOshimura%2C+M%3BKoi%2C+M&rft.aulast=Barrett&rft.aufirst=J&rft.date=1986-01-01&rft.volume=39&rft.issue=&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Symposium+on+Fundamental+Cancer+Research&rft.issn=01901214&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-27 N1 - Date created - 1988-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cellular and molecular mechanisms of carcinogenesis in lining epithelia. AN - 77329995; 3321307 AB - Lining epithelia are the major target sites for cancer in man. The induction of carcinomas on mouse skin following the application of chemical agents is the prototype model for cancer development in a lining epithelium. In this tissue, the earliest carcinogen-induced lesion, initiation, results in an epidermal cell with an altered program of terminal differentiation. Such "initiated" cells can be selected in culture since normal cells can be induced to terminally differentiate by Ca2+ or phorbol ester tumor promoters and will be lost from the cultured population. In situ, the growth of initiated cells is suppressed by surrounding normal cells. The differentiation-inducing effects of tumor promoters on normal cells, therefore, are essential in providing a selective growth advantage which results in the clonal selection of initiated cells and the evolution of a papilloma. This benign tumor is the pathological manifestation of the initiated phenotype. The c-rasH gene appears to be one target for initiating carcinogens, as a mutated and activated form of this gene is frequently isolated from chemically induced papillomas. Furthermore, the introduction of an activated rasH gene into cultured normal keratinocytes produces papillomas when the cells are transplanted as a skin graft in vivo. After a long latency period, some papillomas convert to carcinomas. Since the conversion process can be accelerated and the frequency enhanced by mutagens, it is presumed that genetic damage in papilloma cells plays an important role in malignant conversion. In papilloma cells lacking an activated rasH oncogene, introduction of an exogenous rasH oncogene leads to malignant progression. Thus, mutation and activation of this gene can contribute to early or late events in skin carcinogenesis. In either case it appears that the rasH oncogene must cooperate with other genetic changes to contribute to the malignant phenotype. JF - Symposium on Fundamental Cancer Research AU - Yuspa, S H AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892. Y1 - 1986 PY - 1986 DA - 1986 SP - 3 EP - 15 VL - 39 SN - 0190-1214, 0190-1214 KW - Carcinogens KW - 0 KW - Index Medicus KW - Animals KW - Epithelial Cells KW - Cells, Cultured KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77329995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Symposium+on+Fundamental+Cancer+Research&rft.atitle=Cellular+and+molecular+mechanisms+of+carcinogenesis+in+lining+epithelia.&rft.au=Yuspa%2C+S+H&rft.aulast=Yuspa&rft.aufirst=S&rft.date=1986-01-01&rft.volume=39&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Symposium+on+Fundamental+Cancer+Research&rft.issn=01901214&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-27 N1 - Date created - 1988-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mechanical Support for the Failing Heart AN - 21205593; 11620332 AB - The National Heart, Lung, and Blood Institute (NHLBI) has sponsored considerable research directed toward basic studies on the etiology of heart disease and atherosclerosis. While progress has been very encouraging there are still significant numbers of patients with end-stage heart disease. NHLBI initiated goal-oriented research activities on the artificial heart based upon the recommendation of the National Heart Advisory Council in 1964. The major goal of the Artificial Heart Program was to develop devices which could be effectively used to rehabilitate patients with end-stage heart disease. This paper will describe the evolution and specific program goals of the Artificial Heart Program and provide a description of the left ventricular assist stystem (LVAS) and total artificial heart (TAH) research efforts. Specific attention will be directed toward defining device requirements, descriptions of the blood pump and energy converter, control system operation and energy transmission methods. A summary of experimental results and current development status will also be provided. JF - Journal of Biomaterials Applications AU - Altieri, F D AU - Watson, J T AU - Taylor, K D AD - National Heart, Lung and Blood Institute Devices and Technology Branch Division of Heart and Vascular Diseases Room 312, Federal Building 7550 Wisconsin Avenue Bethesda, MD 20892 Y1 - 1986 PY - 1986 DA - 1986 SP - 106 EP - 156 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 1 IS - 1 SN - 0885-3282, 0885-3282 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Blood KW - Ventricle KW - Etiology KW - Energy KW - Arteriosclerosis KW - Heart diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21205593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomaterials+Applications&rft.atitle=Mechanical+Support+for+the+Failing+Heart&rft.au=Altieri%2C+F+D%3BWatson%2C+J+T%3BTaylor%2C+K+D&rft.aulast=Altieri&rft.aufirst=F&rft.date=1986-01-01&rft.volume=1&rft.issue=1&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomaterials+Applications&rft.issn=08853282&rft_id=info:doi/10.1177%2F088532828600100104 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Heart; Blood; Etiology; Ventricle; Energy; Arteriosclerosis; Heart diseases DO - http://dx.doi.org/10.1177/088532828600100104 ER - TY - JOUR T1 - Preferential metabolism of N-nitrosodiethylamine by two cell lines derived from human pulmonary adenocarcinomas. AN - 15195975; 1968644 AB - Diethylnitrosamine (DEN), in common with other nitrosamines, is a carcinogenic agent which produces tumors in a wide variety of tissues in experimental animals. The metabolism of ( super(14)C)DEN was studied in two cell lines derived from human lung adenocarcinomas and two cell lines derived from human small cell lung cancers by monitoring super(14)CO sub(2) production and covalent binding or radiolabel from ( super(14)C)DEN to the cell protein and DNA fractions. ( super(14)C)DEN was metabolized by adenocarcinoma-derived NCI-H322 (with Clara cell features) and NCI-H358 (with features of alveolar type II cells) but not by NCI-H69 and NCI-H128 (derived from small cell carcinoma). Metabolism was markedly inhibited by heat denaturation of the cell protein. ( super(14)C)DEN metabolism by NCI-H322 was greatly decreased when the incubation was carried out under (i) anaerobic conditions and (ii) in the presence of a carbon monoxide enriched atmosphere. JF - Carcinogenesis AU - Falzon, M AU - McMahon, J B AU - Gazdar, A F AU - Schuller, H M AD - Pathol. and Ultrastruct. Oncol. Sect., LETM, DTP, DCT, NCI, Build. 37, Rm. 5C11, NIH, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 17 EP - 22 VL - 7 IS - 1 SN - 0143-3334, 0143-3334 KW - N-nitrosodiethylamine KW - metabolism KW - Toxicology Abstracts KW - tumor cell lines KW - lung KW - man KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15195975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Preferential+metabolism+of+N-nitrosodiethylamine+by+two+cell+lines+derived+from+human+pulmonary+adenocarcinomas.&rft.au=Falzon%2C+M%3BMcMahon%2C+J+B%3BGazdar%2C+A+F%3BSchuller%2C+H+M&rft.aulast=Falzon&rft.aufirst=M&rft.date=1986-01-01&rft.volume=7&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - tumor cell lines; lung; man ER - TY - JOUR T1 - Physalaemin-like immunoreactive peptides from rabbit stomach. AN - 14963931; 1791014 AB - Two physalaemin (PHY)-like immunoreactive peptide, designated PHLIPs, have been purified from extracts of rabbit stomach tissue. The sequences of PHLIPs-7 and -8 were confirmed with synthetic peptides. The PHY-antiserum cross-reactivity of the PHLIPs relfects homology at amono acid residues 1, 3, 4 and 5 for the mammlian and amphibian residues. JF - International Journal of Peptide and Protein Reseach AU - Wilson, W E AU - Harvan, D J AU - Hamm, C AU - Lazarus, L H AU - Klapper, D G AU - Yajima, H AU - Hayashi, Y AD - Lab. Behav. and Neurol. Toxicol. N.I.E.H.S., Research Triangle Park, NC 27709, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 58 EP - 66 VL - 28 IS - 1 SN - 0367-8377, 0367-8377 KW - immunoreactivity KW - peptides KW - physalaemin KW - purification KW - rabbits KW - stomach KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14963931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Peptide+and+Protein+Reseach&rft.atitle=Physalaemin-like+immunoreactive+peptides+from+rabbit+stomach.&rft.au=Wilson%2C+W+E%3BHarvan%2C+D+J%3BHamm%2C+C%3BLazarus%2C+L+H%3BKlapper%2C+D+G%3BYajima%2C+H%3BHayashi%2C+Y&rft.aulast=Wilson&rft.aufirst=W&rft.date=1986-01-01&rft.volume=28&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Peptide+and+Protein+Reseach&rft.issn=03678377&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Concomitant illness in patients treated for Hodgkin's disease. AN - 14962231; 1787881 JF - Cancer Treatment Reviews AU - Bookman, MA AU - Longo, D L AD - Med. Branch, N.C.I., N.I.H., Build. 10, Rm. 12-N-226, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 77 EP - 111 VL - 13 IS - 2 SN - 0305-7372, 0305-7372 KW - treatment KW - risks KW - complications KW - Toxicology Abstracts KW - Hodgkin's disease KW - man KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14962231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Treatment+Reviews&rft.atitle=Concomitant+illness+in+patients+treated+for+Hodgkin%27s+disease.&rft.au=Bookman%2C+MA%3BLongo%2C+D+L&rft.aulast=Bookman&rft.aufirst=MA&rft.date=1986-01-01&rft.volume=13&rft.issue=2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Cancer+Treatment+Reviews&rft.issn=03057372&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Hodgkin's disease; man ER - TY - JOUR T1 - Nonfibrous dust and cancer: Studies at the National Cancer Institute. AN - 14903058; 1729350 AB - The Environmental Epidemiology Branch of the NCI is conducting several investigations that will evaluate the relationship between cancer risk and exposure to silica and other nonfibrous dust particles. JF - CANCER RES. MONOGR. AU - Thomas, T L AU - Stewart, P A AU - Blair, A AD - Environ. Epidemiol. Branch, NCI, Bethesda, MD 20205, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 441 EP - 450 VL - 2 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - epidemiology KW - particulates KW - dust KW - risk assessment KW - cancer KW - H SE3.20:AIR POLLUTION/AIR QUALITY KW - H SM6.8.7:DUST KW - P 0000:AIR POLLUTION KW - H SM10.21:CANCER KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14903058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CANCER+RES.+MONOGR.&rft.atitle=Nonfibrous+dust+and+cancer%3A+Studies+at+the+National+Cancer+Institute.&rft.au=Thomas%2C+T+L%3BStewart%2C+P+A%3BBlair%2C+A&rft.aulast=Thomas&rft.aufirst=T&rft.date=1986-01-01&rft.volume=2&rft.issue=&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=CANCER+RES.+MONOGR.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - dust; cancer; epidemiology; risk assessment; particulates ER - TY - JOUR T1 - Quantitative structure-activity relationship of the mutagenicity of substituted N-nitroso-N-benzylmethylamines: Possible implications for carcinogenicity. AN - 14819229; 1668919 AB - The relative mutagenicities of substituted N-nitroso-N-benzylmethylamines have been reexamined from a quantitative structure-activity relationship point of view. Most of the compounds were mutagenic toward Salmonella typhimurium TA 1535 with Aroclor-induced male hamster liver S9 activation. The dose-response data were subjected to a multiple linear regression equation calculated in a stepwise manner, which found that the differences in mutagenicities could be explained primarily by differences in the three-bond path molecular connectivity index, with smaller contributions from sigma and pi . Moreover, a polynomial regression analysis showed that the maximum mutagenicity could be explained by an optimal amount of electron withdrawal by the substituent which would cause a weakening, or activation, of the methylene C-H bond. The possible relevance of these observations to carcinogenesis is discussed. JF - Journal of Medicinal Chemistry AU - Singer, G M AU - Andrews, A W AU - Guo, SA AD - NCI-Frederick Cancer Res. Facil., LBI-Basic Res. Program, Program Resour. Inc., Inf. Manage. Serv., Frederick, MD 21701, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 40 EP - 43 VL - 29 IS - 1 SN - 0022-2623, 0022-2623 KW - derivatives KW - structure-activity relationships KW - N-nitroso-N-benzylmethylamine KW - Toxicology Abstracts KW - Ames test KW - mutagenicity KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14819229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Quantitative+structure-activity+relationship+of+the+mutagenicity+of+substituted+N-nitroso-N-benzylmethylamines%3A+Possible+implications+for+carcinogenicity.&rft.au=Singer%2C+G+M%3BAndrews%2C+A+W%3BGuo%2C+SA&rft.aulast=Singer&rft.aufirst=G&rft.date=1986-01-01&rft.volume=29&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - mutagenicity; Ames test ER - TY - JOUR T1 - Guidelines for combining neoplasms for evaluation of rodent carcinogenesis studies. AN - 14774428; 1630374 AB - In a continuing review of long-term toxicology and carcinogenesis studies in rats and mice, the National Toxicology Program (NTP) is confronted with many problems concerning the interpretation of tumor data. A frequently raised question is: "Should certain neoplasms be combined for overall assessment of rodent carcinogenesis data?" NTP policy is that certain neoplasms may be combined for statistical assessment of tumor data and that hyperplastic responses may be used as supportive evidence. The primary season for combining neoplastic lesions is to gain more insight into the evidence of the carcinogenicity of a given chemical in that species of animal. This report gives the rationale, criteria, and guidelines used by the NTP for combining neoplasms for the evaluation of long-term rodent toxicology and carcinogenesis studies. JF - Journal of the National Cancer Institute AU - McConnell, EE AU - Solleveld, HA AU - Swenberg, JA AU - Boorman, G A AD - NTP/NIEHS, Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 283 EP - 289 VL - 76 IS - 2 SN - 0027-8874, 0027-8874 KW - evaluation KW - combination KW - Toxicology Abstracts KW - reviews KW - carcinogenesis KW - data KW - neoplasia KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14774428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Guidelines+for+combining+neoplasms+for+evaluation+of+rodent+carcinogenesis+studies.&rft.au=McConnell%2C+EE%3BSolleveld%2C+HA%3BSwenberg%2C+JA%3BBoorman%2C+G+A&rft.aulast=McConnell&rft.aufirst=EE&rft.date=1986-01-01&rft.volume=76&rft.issue=2&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenesis; data; neoplasia; reviews ER - TY - JOUR T1 - Chronic bioassay of benzyl chloride in F344 rats and (C57BL/6J x BALB/c)F sub(1) mice. AN - 14772634; 1630794 AB - Benzyl chloride was administered to groups of 52 male and 52 female F344 rats and (C57BL/6J X BALB/c)F sub(1) mice at two dose levels by gavage in corn oil three times a week for 2 years. Survivors were sacrificed a few weeks later and examined histopathologically. On the basis of a subchronic study at a range of doses, the doses of benzyl chloride in the chronic study were 100 and 50 mg/kg body weight for mice and 30 and 15 mg/kg body weight for rats. In mice of both sexes there was a high and statistically significant incidence of carcinomas and papillomas of the forestomach. In the livers of male mice, but not of females, there was a significantly increased incidence of hepatocellular neoplasms at the low dose but not at the maximally tolerated dose (MTD). In rats the only neoplasms showing a statistically significant increase compared with controls were C-cell neoplasms of the thyroid gland in females. JF - Journal of the National Cancer Institute AU - Lijinsky, W AD - Basic Res. Program-Litton Bionetics, Inc., Lab. Chem. and Phys. Carcinog., NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 1231 EP - 1236 VL - 76 IS - 6 SN - 0027-8874, 0027-8874 KW - benzyl chloride KW - mice KW - rats KW - Toxicology Abstracts KW - thyroid KW - liver KW - stomach KW - carcinoma KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14772634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Chronic+bioassay+of+benzyl+chloride+in+F344+rats+and+%28C57BL%2F6J+x+BALB%2Fc%29F+sub%281%29+mice.&rft.au=Lijinsky%2C+W&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1986-01-01&rft.volume=76&rft.issue=6&rft.spage=1231&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinoma; stomach; liver; thyroid ER - TY - JOUR T1 - Tissue levels and biological effects of N-nitrosodimethylamine in mice during chronic low or high dose exposure with or without ethanol. AN - 14771833; 1631191 AB - In a study of the metabolism, disposition, and hepatotoxicity of the environmental carcinogen N-nitrosodimethylamine (NDMA), as a function of dose in the drinking water and of concomitant administration of ethanol, outbred Swiss mice were given NDMA for 1-4 weeks at levels of 50-0.5 ppm, with or without 10, 20, or 30% ethanol. NDMA, assayed in blood, liver, kidney, lung, and brain by thermal anergy analysis after methylene chloride extraction, was detectable (> 0.5 ppb) in tissues of the mice after all doses of NDMA. The 0.5-ppm dose yielded tissue levels of NDMA (1-4 ppb) near the detection limit of 0.5 ppb; this was also found to be the minimal concentration causing significant numbers of lung tumors in strain A mice after treatment for 16-18 weeks. Co-administration of ethanol caused an increase in blood and tissue levels of NDMA at all levels of both chemicals, often by a factor of 10 or more. JF - Drug Metabolism and Disposition AU - Anderson, L M AU - Harrington, G W AU - Pylypiw, HM Jr AU - Hagiwara, A AU - Magee, P N AD - NCI-LCC, Build. 538, Rm. 205-E, Fort Detrick, Frederick, MD 21701, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 733 EP - 739 VL - 14 IS - 6 SN - 0090-9556, 0090-9556 KW - organs KW - concentration KW - toxicity KW - N-nitrosodimethylamine KW - ethanol KW - mice KW - Toxicology Abstracts KW - X 24200:Nitrosamines & related compounds KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14771833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Metabolism+and+Disposition&rft.atitle=Tissue+levels+and+biological+effects+of+N-nitrosodimethylamine+in+mice+during+chronic+low+or+high+dose+exposure+with+or+without+ethanol.&rft.au=Anderson%2C+L+M%3BHarrington%2C+G+W%3BPylypiw%2C+HM+Jr%3BHagiwara%2C+A%3BMagee%2C+P+N&rft.aulast=Anderson&rft.aufirst=L&rft.date=1986-01-01&rft.volume=14&rft.issue=6&rft.spage=733&rft.isbn=&rft.btitle=&rft.title=Drug+Metabolism+and+Disposition&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - High-performance ion-exchange chromatographic separation of protegolycans. AN - 14742222; 1596720 AB - Proteoglycans synthesized by cultured human muscle cells were separated by ion-exchange high-performance liquid chromatography using a Bio-gel TSK DEAE 5-PW analytical column. The technique has been applied to the analysis of chondroitinase-digested samples and is particularly useful for rapid screening of large numbers of cultures for both biosynthetic rate studies and analysis of patterns of proteoglycan synthesis. JF - Analytical Biochemistry AU - Harper, G S AU - O'Shannessy, D J AU - Gahl, WA AD - Sect. Human Biochem. Genet., Human Genet. Branch, NICHD, Build. 10, Rm. 10N-318, NIH, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 150 EP - 156 VL - 159 IS - 1 SN - 0003-2697, 0003-2697 KW - glycoproteins KW - ion-exchange chromatography KW - isolation KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14742222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=High-performance+ion-exchange+chromatographic+separation+of+protegolycans.&rft.au=Harper%2C+G+S%3BO%27Shannessy%2C+D+J%3BGahl%2C+WA&rft.aulast=Harper&rft.aufirst=G&rft.date=1986-01-01&rft.volume=159&rft.issue=1&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - The effect of tricaine anesthesia upon induction of select P-450 dependent monooxygenase activities in rainbow trout (Salmo gairdneri ). AN - 14708277; 1561585 AB - The effect of surgical plane tricaine anesthesia upon the induction and constitutive activities of select hepatic monooxygenases, and cytochrome(s) P-450 of rainbow trout was investigated. In contrast to findings in studies with other species, tricaine produce no observable effect upon constitutive cytochrome(s) P-450 levels. Similarly, ethoxycoumarin-O-deethylase (ECOD), benzphetamine-N-demethylation (BEND) and aminopyrine-N-demethylation (APD) activities appeared to be marginally decreased suggesting perhaps a limited inhibitory effect upon P-448-like cytochromes. The induction of the de novo synthesis of beta -naphthoflavone (BNF)-inducible P-488 forms(s) or associated monooxygenase activities was unaffected by a tricaine exposure in regards to the magnitude or time-course of the induction. JF - Aquatic Toxicology AU - Kleinow, K M AU - Haasch, M L AU - Lech, J J AD - NIEHS Aquat. Biomed. Cent., Dep. Pharmacol. and Toxicol., Med. Coll. Wisconsin, Milwaukee, WI 53226, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 231 EP - 241 VL - 8 IS - 4 SN - 0166-445X, 0166-445X KW - Salmo gairdneri KW - activity KW - anesthetics KW - cytochrome P450 KW - cytochromes KW - enzymatic activity KW - fish physiology KW - monooxygenase KW - toxicity tests KW - tricaine KW - tricaine anesthesia KW - ASFA 3: Aquatic Pollution & Environmental Quality; Pollution Abstracts; Oceanic Abstracts; Toxicology Abstracts KW - Freshwater KW - enzymes KW - toxicity KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - X 24117:Biochemistry KW - P 2000:FRESHWATER POLLUTION KW - Q5 08504:Effects on organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14708277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+Toxicology&rft.atitle=The+effect+of+tricaine+anesthesia+upon+induction+of+select+P-450+dependent+monooxygenase+activities+in+rainbow+trout+%28Salmo+gairdneri+%29.&rft.au=Kleinow%2C+K+M%3BHaasch%2C+M+L%3BLech%2C+J+J&rft.aulast=Kleinow&rft.aufirst=K&rft.date=1986-01-01&rft.volume=8&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Aquatic+Toxicology&rft.issn=0166445X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-05 N1 - SubjectsTermNotLitGenreText - toxicity; toxicity tests; enzymatic activity; fish physiology; enzymes; anesthetics; Freshwater ER - TY - JOUR T1 - Rapid and effective transfer of integral membrane proteins from isoelectric focusing gels to nitrocellulose membranes. AN - 14688160; 1552828 AB - A method describing the rapid and effective transfer of integral membrane protein from isoelectric focusing gels to nitrocellulose is described. Initial experiments were carried out with detergent solubilized extracts of human erythrocyte membrane proteins. The effectiveness of the transfer was demonstrated by assaying for erythrocyte glucose transporter, an integral membrane protein using specific antibodies followed by super(125)I-protein A and autoradiography. Several detergents including octyl glucoside, Tritton X-100 and CHAPS were used in this study but only octyl glucoside effectively solubilized the glucose transporter and did not interfere with the electrotransfer of the protein. The glucose transporter separated on isoelectric focusing gels was effectively transferred after 2 h of electroblotting and was found to have an apparent pI of 6 4-6.5. JF - Analytical Biochemistry AU - Matthaei, S AU - Baly, D L AU - Horuk, R AD - NIEHS, NIH, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 123 EP - 128 VL - 157 IS - 1 SN - 0003-2697, 0003-2697 KW - isoelectric focusing KW - membrane proteins KW - methodology KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14688160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=Rapid+and+effective+transfer+of+integral+membrane+proteins+from+isoelectric+focusing+gels+to+nitrocellulose+membranes.&rft.au=Matthaei%2C+S%3BBaly%2C+D+L%3BHoruk%2C+R&rft.aulast=Matthaei&rft.aufirst=S&rft.date=1986-01-01&rft.volume=157&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Isolation of human glucose-6-phosphate dehydrogenase (G6PD) cDNA clones: Primary structure of the protein and unusual 5' non-coding region. AN - 14682926; 1553596 AB - Glucose-6-phosphate dehydrogenase (G6PD) is an ubiquitous enzyme which be determining the NADPH level has a crucial role in NADPH-mediated reductive processes in all cells. The structural gene for G6PD, Gd , is X-linked in mammals and on the basis of its expression in many tissues, it can be regarded as a typical "housekeeping" gene. The authors report the isolation of cDNA clones from HeLa cells, SV40-transformed human fibroblasts, human placenta and human teratocarcinoma cell lines. These clones have enabled authors to sequence the entire coding region of Gd . Thus, the entire amino acid sequence of human G6PD is provided for the first time. JF - Nucleic Acids Research AU - Persico, M G AU - Viglietto, G AU - Martini, G AU - Tomiolo, D AU - Paonessa, G AU - Moscatelli, C AU - Dono, R AU - Vulliamy, T AU - Liuzzatto, L AU - D'Urso, M AD - Hum. Genet. Branch, NICHD, Natl. Inst. Health, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 2511 EP - 2522 VL - 19 IS - 6 SN - 0305-1048, 0305-1048 KW - 5'-terminus KW - Gd gene KW - amino acid sequence KW - cDNA KW - genes KW - glucose-6-phosphate dehydrogenase KW - man KW - nucleotide sequence KW - predictions KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - N 14640:Structure & sequence KW - G 07430:Chromosome studies/nucleotide sequence KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14682926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Isolation+of+human+glucose-6-phosphate+dehydrogenase+%28G6PD%29+cDNA+clones%3A+Primary+structure+of+the+protein+and+unusual+5%27+non-coding+region.&rft.au=Persico%2C+M+G%3BViglietto%2C+G%3BMartini%2C+G%3BTomiolo%2C+D%3BPaonessa%2C+G%3BMoscatelli%2C+C%3BDono%2C+R%3BVulliamy%2C+T%3BLiuzzatto%2C+L%3BD%27Urso%2C+M&rft.aulast=Persico&rft.aufirst=M&rft.date=1986-01-01&rft.volume=19&rft.issue=6&rft.spage=2511&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - nucleotide sequence; cDNA; amino acid sequence; genes ER - TY - JOUR T1 - Biosynthesis and chemical and immunological characterization of avian reticuloendotheliosis virus env gene-encoded proteins. AN - 14679973; 1553128 AB - Two glycosylated proteins designated gp90 and gp20 were purified from replication-competent avian reticuloendotheliosis associated virus (REV-A). The N-terminal sequences of gp90 and gp20 were determined and found to match the REV-A-env -gene sequence. The alignments of the determined amino acid sequences with the predicted sequence indicate that gp20 and gp90 are the REV-A-encoded viral transmembrane and surface glycoprotein, respectively, and predict a signal peptide of 36 residues on the 5 end of the env -gene. Evolutionary aspects of these findings are discussed. JF - Virology AU - Tsai, W-P AU - Copeland, T D AU - Oroszlan, S AD - BRI-Basic Res. Program, Lab. Mol. Virol. and Carcinog., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 567 EP - 583 VL - 155 IS - 2 SN - 0042-6822, 0042-6822 KW - amino acid sequence KW - avian reticuloendotheliosis virus KW - env gene KW - genes KW - proteins KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Virology & AIDS Abstracts KW - G 07313:Viruses KW - V 22032:Viral proteins KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14679973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Biosynthesis+and+chemical+and+immunological+characterization+of+avian+reticuloendotheliosis+virus+env+gene-encoded+proteins.&rft.au=Tsai%2C+W-P%3BCopeland%2C+T+D%3BOroszlan%2C+S&rft.aulast=Tsai&rft.aufirst=W-P&rft.date=1986-01-01&rft.volume=155&rft.issue=2&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - genes; amino acid sequence ER - TY - JOUR T1 - Comparison of the activity of phorbol 12-myristate 13-acetate and the diglyceride glycerol 1-myristate 2-acetate. AN - 14671572; 1537907 AB - Diglycerides function as analogs of the phorbol ester tumor promoters. The authors compare here the activity of glycerol 1-myristate 2-acetate (GMA) with the corresponding phorbol 12-myristate 13-acetate (PMA). GMA inhibited phorbol ester binding to reconstituted protein kinase C, stimulated protein kinase C enzymatic activity, and, upon addition to intact 3T3 cells, inhibited ( super(125)I)EGF binding. Its potency was much less than that of PMA, however (2.9 x 10 super(4)-fold less for phorbol ester binding, > 1.2 x 10 super(5)-fold less for inhibition of EGF binding), and its activity on the intact cells was more transient. The marked difference in potency contrasts with the much smaller differences found previously for the corresponding pairs of dilaurate and dioleate derivatives. JF - Carcinogenesis AU - Sharkey, NA AU - Blumberg, P M AD - Lab. Cell. Carcinog. and Tumor Promot., NCI, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 677 EP - 679 VL - 7 IS - 4 SN - 0143-3334, 0143-3334 KW - GMA KW - PMA KW - effects on KW - binding KW - glycerol 1-myristate 2-acetate KW - phorbol 12-myristate 13-acetate diester KW - Toxicology Abstracts KW - promoters KW - X 24240:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14671572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Comparison+of+the+activity+of+phorbol+12-myristate+13-acetate+and+the+diglyceride+glycerol+1-myristate+2-acetate.&rft.au=Sharkey%2C+NA%3BBlumberg%2C+P+M&rft.aulast=Sharkey&rft.aufirst=NA&rft.date=1986-01-01&rft.volume=7&rft.issue=4&rft.spage=677&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - promoters ER - TY - JOUR T1 - Ethionine carcinogenesis in CD-1, BALB/c and C3H mice. AN - 14671507; 1538052 AB - In two separate in vivo studies, ethionine was evaluated for carcinogenic activity in mice. In the first study, DL-ethionine was fed in a chow diet at 0 (controls), 0.1 (low dose, LD) and 0.25% (high dose, HD) concentrations to the following groups of mice (30 animals/group): Swiss Webster CD-1 females, BALB/c males, and C3H/HeN males and females. The results of the feeding study are compared with those obtained in a second study in which C3H female mice were intubated with 0, 150 or 500 mg DL-ethionine/kg body wt three times per week for 30 weeks and killed at 2 years. The results extend to different strains and to both sexes previous observations demonstrating the hepatocarcinogenic activity of ethionine in mice; and indicate that as in the rat such activity may be exerted through the formation of AdoEt. JF - Carcinogenesis AU - Hoover, K L AU - Hyde, CL AU - Wenk, M L AU - Poirier, LA AD - Build. 538, Rm. 205-J, NCI/FCRF, Frederick, MD 21701-1013, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 1143 EP - 1148 VL - 7 IS - 7 SN - 0143-3334, 0143-3334 KW - strains KW - differences KW - ethionine KW - mice KW - Toxicology Abstracts KW - sex KW - carcinogenesis KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14671507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Ethionine+carcinogenesis+in+CD-1%2C+BALB%2Fc+and+C3H+mice.&rft.au=Hoover%2C+K+L%3BHyde%2C+CL%3BWenk%2C+M+L%3BPoirier%2C+LA&rft.aulast=Hoover&rft.aufirst=K&rft.date=1986-01-01&rft.volume=7&rft.issue=7&rft.spage=1143&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenesis; sex ER - TY - JOUR T1 - Medications and their use in the treatment of adverse reactions to foods. AN - 14667940; 1523565 AB - The treatment of choice for food allergy is avoidance. Unlike aeroallergens that may be ubiquitous in either indoor or outdoor environments and, therefore, difficult to avoid, incriminated allergenic foods can, in many instances, be completely eliminated from the diet. Pharmacologic agents thus play only a secondary role in the management of adverse reactions to foods. Indications for use of medication in the prevention and treatment of food allergy, probable mechanisms of actions of various drugs as they pertain to gastrointestinal reactions, and, where available, results of clinical trials with these drugs in regard to adverse reactions to foods are the topics of this discussion. JF - Journal of Allergy and Clinical Immunology AU - Song, D AD - Asthma/Allergy Branch, NIAID, 5333 Westbard Ave., Westwood Build., Rm. 752, NIH, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 238 EP - 242 VL - 78 IS - 1 SN - 0091-6749, 0091-6749 KW - treatment KW - Toxicology Abstracts KW - hypersensitivity KW - food KW - man KW - X 24120:Food, additives & contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14667940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Medications+and+their+use+in+the+treatment+of+adverse+reactions+to+foods.&rft.au=Song%2C+D&rft.aulast=Song&rft.aufirst=D&rft.date=1986-01-01&rft.volume=78&rft.issue=1&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - food; hypersensitivity; man ER - TY - JOUR T1 - Nitrosamines and nitrosamine precursors in food from Linxian, China, a high incidence area for esophageal cancer. AN - 14667906; 1538346 AB - Nitrosamines and precursor secondary amines were assayed in foods from families in four villages of the esophageal cancer high incidence area of Linxian, Henan Province, People's Republic of China. Amines (as tosylamides) and nitrosamines were readily detected at p.p.m. and p.p.b. levels, respectively, in all samples. In this small preliminary survey (25 families, four villages), however, there were no strong correlations between the levels of the carcinogenic nitrosamines or the precursor secondary amines with the incidence of esophageal cancer in the individual families. The success of the analytical procedures suggests that a more extensive study is warranted. JF - Carcinogenesis AU - Singer, G M AU - Chuan, J AU - Roman, J AU - Hsin, L M AU - Lijinsky, W AD - LBI-Basic Res. Program, Lab. Chem. and Phys. Carcinog., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 733 EP - 736 VL - 7 IS - 5 SN - 0143-3334, 0143-3334 KW - content KW - correlation KW - nitrosamines KW - Toxicology Abstracts KW - esophagus KW - food KW - man KW - carcinoma KW - X 24120:Food, additives & contaminants KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14667906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Nitrosamines+and+nitrosamine+precursors+in+food+from+Linxian%2C+China%2C+a+high+incidence+area+for+esophageal+cancer.&rft.au=Singer%2C+G+M%3BChuan%2C+J%3BRoman%2C+J%3BHsin%2C+L+M%3BLijinsky%2C+W&rft.aulast=Singer&rft.aufirst=G&rft.date=1986-01-01&rft.volume=7&rft.issue=5&rft.spage=733&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - food; esophagus; carcinoma; man ER - TY - JOUR T1 - Lack of effect of phenobarbital on hepatocellular carcinogenesis initiated by N-nitrosodiethylamine or methylazoxymethanol acetate in male Syrian golden hamsters. AN - 14650553; 1523213 AB - Subchronic toxicity and long-term tumor-promoting effects of phenobarbital (PB) were investigated in male Syrian golden hamsters. In subchronic studies, PB was administered in drinking water to 5-week-old male hamsters for periods of 8 or 16 weeks at dosage levels of 250, 500, or 1000 ppm. No significant change in the ratio of liver weight to body weight was observed at 8 weeks; however, at 16 weeks there was a dose-dependent increase in the ratio of liver weight to body weight and a significant decrease in body weight gain among animals that received PB at 1000 ppm. The effect of PB on hepatic cytochrome P-450 and P-450-dependent aminopyrine N-demethylase activity was compared in male syrian golden hamsters, F-344/NCr rats, and B6C3F1 mice. PB enhanced cytochrome P-450 activity in all three species; however, a significant increase in aminopyrine N-demethylase activity was observed only in rats and mice. JF - Toxicology and Applied Pharmacology AU - Diwan, BA AU - Ward, J M AU - Anderson, L M AU - Hagiwara, A AU - Rice, J M AD - Lab. Comp. Carcinog., Div. Cancer Etiol., NCI/Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 298 EP - 307 VL - 86 IS - 2 SN - 0041-008X, 0041-008X KW - effects on KW - N-nitrosodiethylamine KW - methylazoxymethanol acetate KW - phenobarbital KW - hamsters KW - Toxicology Abstracts KW - carcinogenesis KW - liver KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14650553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Lack+of+effect+of+phenobarbital+on+hepatocellular+carcinogenesis+initiated+by+N-nitrosodiethylamine+or+methylazoxymethanol+acetate+in+male+Syrian+golden+hamsters.&rft.au=Diwan%2C+BA%3BWard%2C+J+M%3BAnderson%2C+L+M%3BHagiwara%2C+A%3BRice%2C+J+M&rft.aulast=Diwan&rft.aufirst=BA&rft.date=1986-01-01&rft.volume=86&rft.issue=2&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenesis; liver ER - TY - JOUR T1 - Selenium modifies carcinogen metabolism by inhibiting enzyme induction. AN - 14641102; 1505572 AB - Since selenium has been found to exert a protective action against carcinogenesis in various systems, the mechanism whereby sodium selenite inhibits DNA binding of the carcinogen, 7,12-dimethylbenz(a)anthracene, was investigated. It was found that selenite preferentially reduced DNA binding occurring through an anti-dihydrodiol epoxide metabolite of this carcinogen by inhibiting the induction of an enzyme system that generates this specific reactive metabolite. Although high doses of selenium have been known to be toxic for over 50 yr, epidemiological investigations and laboratory experiments in rodents over the last three decades have indicated that increased intakes of selenium in diet or drinking water can exert a protective effect against cancer. JF - Biological Trace Element Research AU - Dipple, A AU - Pigott, MA AU - Milner, JA AD - LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 153 EP - 158 VL - 10 IS - 2 SN - 0163-4984, 0163-4984 KW - binding KW - effects on KW - metabolism KW - selenium KW - 7,12-dimethylbenz(a)anthracene KW - Toxicology Abstracts KW - carcinogens KW - DNA KW - X 24165:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14641102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Trace+Element+Research&rft.atitle=Selenium+modifies+carcinogen+metabolism+by+inhibiting+enzyme+induction.&rft.au=Dipple%2C+A%3BPigott%2C+MA%3BMilner%2C+JA&rft.aulast=Dipple&rft.aufirst=A&rft.date=1986-01-01&rft.volume=10&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Biological+Trace+Element+Research&rft.issn=01634984&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - DNA; carcinogens ER - TY - JOUR T1 - Randomized comparison between two ceftazidime-containing regimens and cephalothin-gentamicin-carbenicillin in febrile granulocytopenic cancer patients. AN - 14623940; 1495575 AB - Because the results of the authors' published trial of ceftazidime versus cephalothin, gentamicin, and carbenicillin (KGC) revealed a preponderance of gram-positive superinfections, including those caused by clostridia, in patients treated with ceftazidime, they added vancomycin to the ceftazidime regimen at study entry 49 and continued with a 2:1 randomized comparison of ceftazidime-vancomycin (CV) versus KGC. Criteria for study entry were fever (temperature, greater than or equal to 38.5 degree C on one occasion or greater than or equal to 38 degree C on two occasions 6 h apart) and granulocytopenia (< 500/mm super(3) or a falling count anticipated to be < 500/mm super(3)). Ninety-five entries (79 patients) were evaluable. The numbers of initial clinical responses for ceftazidime-, KGC-, and CV-treated patients were 9 of 21 (43%), 21 of 37 (57%), and 21 of 37 (57%), respectively; differences were not significant. JF - Antimicrobial Agents & Chemotherapy AU - Krames, B S AU - Ramphal, R AU - Rand, KH AD - Natl. Cancer Inst., NCI-Navy Med. Oncol. Branch, Naval Hosp., Bethesda, MD 20812, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 64 EP - 68 VL - 30 IS - 1 SN - 0066-4804, 0066-4804 KW - superinfection KW - treatment KW - ceftazidime KW - cephalothin KW - gentamicin KW - carbenicillin KW - Microbiology Abstracts B: Bacteriology KW - immunocompromised hosts KW - gram-positive bacteria KW - man KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14623940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Randomized+comparison+between+two+ceftazidime-containing+regimens+and+cephalothin-gentamicin-carbenicillin+in+febrile+granulocytopenic+cancer+patients.&rft.au=Krames%2C+B+S%3BRamphal%2C+R%3BRand%2C+KH&rft.aulast=Krames&rft.aufirst=B&rft.date=1986-01-01&rft.volume=30&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - gram-positive bacteria; immunocompromised hosts; man ER - TY - JOUR T1 - Biotransformation of xenobiotics in individual rabbit hepatocytes. Application of microspectrofluorometry. AN - 14614145; 1485367 AB - The authors have investigated several methods for the determining rates of xenobiotic biotransformation in individual rabbit hepatocytes by microspectrofluorometry. Experiments designed to measure monooxygenase activity by following fluorescent product formation (i.e. 7-ethoxycoumarin deethylase or oxidation of the fluorescein derivatives ethoxyfluorescein ethyl ester and 5- and 6-ethoxycarbonyl ethoxylfluorescein ethyl ester) demonstrated that the fluorescent products were released from cells to the surrounding media. Thus, metabolically active cells probably had underestimated activities, and inactive cells could accumulate fluorescent product and appear metabolically active. The authors also utilized benzo(a)pyrene (BP) as a substrate in this system. By selecting appropriate wavelengths (370 nm excitation, 407 nm emission), it was possible to selectively monitor BP disappearance in single cells. JF - Drug Metabolism and Disposition AU - Massey, TE AU - Devereux, T R AU - Fouts, J R AD - Lab. Pharmacol., NIEHS/NIH, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 319 EP - 324 VL - 14 IS - 3 SN - 0090-9556, 0090-9556 KW - metabolism KW - rate determination KW - rabbits KW - Toxicology Abstracts KW - spectrofluorometry KW - hepatocytes KW - chemicals KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14614145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Metabolism+and+Disposition&rft.atitle=Biotransformation+of+xenobiotics+in+individual+rabbit+hepatocytes.+Application+of+microspectrofluorometry.&rft.au=Massey%2C+TE%3BDevereux%2C+T+R%3BFouts%2C+J+R&rft.aulast=Massey&rft.aufirst=TE&rft.date=1986-01-01&rft.volume=14&rft.issue=3&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Drug+Metabolism+and+Disposition&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - chemicals; spectrofluorometry; hepatocytes ER - TY - JOUR T1 - Two forms of phosphatidylinositol-specific phospholipase C from bovine brain. AN - 14609732; 1482888 AB - Two immunologically distinct forms of phosphoinositide-specific phospholipase C were purified to near homogeneity from bovine brain. Their molecular weights determined by SDS-PAGE are 150,000 (enzyme I) and 145,000 (enzyme II), respectively. Under a nondenaturing condition, purified enzyme I exists mainly in dimeric form and as tetramer to a small extent, while enzyme II is predominantly in monomer, to a small extent as dimer and to a very small extent as trimer. Multiple forms of phosphoinositide-specific phospholipase C in brain tissue described in the literature might be, therefore, attributed to the oligomerization of the two independent forms. JF - Biochemical and Biophysical Research Communications AU - Ryu, SH AU - Cho, K S AU - Lee, KY AU - Suh, P-G AU - Rhee, S G AD - Lab. Biochem., NHLBI, NIH, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 137 EP - 144 VL - 141 IS - 1 SN - 0006-291X, 0006-291X KW - brain KW - cattle KW - forms KW - molecular weight KW - phospholipase C KW - quaternary structure KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - N3 11070:Neurochemistry and cellular biology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14609732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Two+forms+of+phosphatidylinositol-specific+phospholipase+C+from+bovine+brain.&rft.au=Ryu%2C+SH%3BCho%2C+K+S%3BLee%2C+KY%3BSuh%2C+P-G%3BRhee%2C+S+G&rft.aulast=Ryu&rft.aufirst=SH&rft.date=1986-01-01&rft.volume=141&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - molecular weight; quaternary structure; brain ER - TY - JOUR T1 - Evidence for the association of I-A and I-E molecules in d-haplotype mice. AN - 14590360; 1470249 AB - Previous studies using sequential immunoprecipitation indicated the existence of two I-E molecules in d-haplotype mice. Using N-terminal amino acid radiosequence analysis, the authors have shown that the sequence of the alpha - and beta -chains from the I-E molecules, which is immunoprecipitated by a monoclonal antibody (14.4.4S), is consistent with that determined for the gene of the I-E super(d) molecule. The material, which is immunoprecipitated by an anti-I-E super(d) alloantiserum ((B10 x D2.GD)F sub(1) anti-B10.D2) after preclearing with 12.4.4S, has a N-terminal amino acid sequence consistent with it being a mixture of the I-E super(d) and I-A super(d) alpha - and beta -chains. The amount of I-A super(d) varied with each preparation, ranging from 15 to 40% of the total. Nonequilibrium pH gradient gel electrophoresis fractionation of the beta -chain pool precipitated by the alloantiserum yielded two molecules. One molecule had an A super(d) beta N-terminal amino acid sequence and the other had an E super(d) beta N-terminal sequence. The existence of antibodies cross-reactive with I-A in the anti-I-E alloantiserum were ruled out because this antiserum could not immunoprecipitate any I-A super(d) molecules from a D2.GD spleen cell lysate. Therefore, the authors conclude that the alloantiserum is recognizing determinants that are formed by an interaction between I-A super(d) and I-E super(d) molecules or their subunits. JF - Molecular Immunology AU - Maloy, W L AU - Ozato, K AU - Sachs, D H AU - Coligan, JE AD - Lab. Immunogenet., Build. 5, Rm. B1-04, NIAID, NIH, Bethesda, MD 20893, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 263 EP - 269 VL - 23 IS - 3 SN - 0161-5890, 0161-5890 KW - I determinants KW - N-terminus KW - amino acid sequence KW - haplotypes KW - histocompatibility system H-2 KW - immunoprecipitation KW - major histocompatibility complex KW - mice KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - F 06824:Animal KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14590360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Immunology&rft.atitle=Evidence+for+the+association+of+I-A+and+I-E+molecules+in+d-haplotype+mice.&rft.au=Maloy%2C+W+L%3BOzato%2C+K%3BSachs%2C+D+H%3BColigan%2C+JE&rft.aulast=Maloy&rft.aufirst=W&rft.date=1986-01-01&rft.volume=23&rft.issue=3&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Molecular+Immunology&rft.issn=01615890&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - amino acid sequence; major histocompatibility complex ER - TY - CONF T1 - Prevention of allergic reactions to penicillin. AN - 14589219; 1470331 AB - Adverse reactions to medications are a significant cause of both morbidity and mortality in the United States. Penicillin and its multiple semisynthetic analogues are no exceptions. Between 1% and 10% of all patients undergoing treatment with these drugs develop reactions to them. This article is concerned with the immunologic reactions mediated by reaginic or IgE antibody. Manifestations of this type of reaction include urticaria, angioedema, laryngospasm, bronchospasm, and anaphylactic shock. The most effective means for eliminating allergic reactions to the penicillins, is avoidance. Ideally, the goal is to withhold therapy from those destined to have reactions and administer it only to those unlikely to have reactions. Ways of discriminating the two populations have been the focus of much research and a discussion of these risk factors ensues. JF - Journal of Allergy and Clinical Immunology AU - Sogn, D D Y1 - 1986 PY - 1986 DA - 1986 SP - 1051 EP - 1052 VL - 78 IS - 5 KW - prevention KW - penicillin KW - Immunology Abstracts; Toxicology Abstracts KW - hypersensitivity KW - reviews KW - immunoglobulin E KW - man KW - F 06846:Clinical KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14589219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Prevention+of+allergic+reactions+to+penicillin.&rft.au=Sogn%2C+D+D&rft.aulast=Sogn&rft.aufirst=D&rft.date=1986-01-01&rft.volume=78&rft.issue=5&rft.spage=1051&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Hollow fiber microfiltration methods for recovery of rat basophilic leukemia cells (RBL-2H3) from tissue culture media. AN - 14585953; 1470101 AB - The purpose here is to discuss some operating experience with the use of hollow fiber tangential flow filters for recovery of rat basophilic leukemia cells (RBL-2H3) grown in suspension culture. These cells have histamine-containing granules and receptors for IgE and have been used as a model to study the IgE receptor interaction. JF - Biotechnology Progress AU - Shiloach, J AU - Kaufman, J B AD - Biotechnol. Unit, NIDDK, Natl. Inst. Health, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 230 EP - 233 VL - 2 IS - 4 SN - 8756-7938, 8756-7938 KW - basophilic leukemia KW - cells KW - recovery KW - rats KW - filtration KW - tissue culture KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - F 06725:Leukocyte isolation, characterization & preservation KW - W 30330:Animals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14585953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+Progress&rft.atitle=Hollow+fiber+microfiltration+methods+for+recovery+of+rat+basophilic+leukemia+cells+%28RBL-2H3%29+from+tissue+culture+media.&rft.au=Shiloach%2C+J%3BKaufman%2C+J+B&rft.aulast=Shiloach&rft.aufirst=J&rft.date=1986-01-01&rft.volume=2&rft.issue=4&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Biotechnology+Progress&rft.issn=87567938&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - tissue culture; filtration ER - TY - JOUR T1 - Isolation and characterization of spicule proteins from Strongylocentrotus purpuratus . AN - 14562600; 1445774 AB - A simple method is described for the isolation of spicules from pluteus embryos of the sea urchin, Strongylocentrotus purpuratus . Radio-iodination of the demineralized matrix reveals six bands on SDS protein gels. Treatment with N-glycanase leads us to believe that some of these proteins are N-linked glycoproteins. JF - Experimental Cell Research AU - Venkatesan, M AU - Simpson, R T AD - NIH/NIDDK, 9000 Rockville Pike, Build. 6, Rm. B1-34, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 259 VL - 166 IS - 1 SN - 0014-4827, 0014-4827 KW - Strongylocentrotus purpuratus KW - characterization KW - embryos KW - proteins KW - purification KW - spicules KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14562600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Cell+Research&rft.atitle=Isolation+and+characterization+of+spicule+proteins+from+Strongylocentrotus+purpuratus+.&rft.au=Venkatesan%2C+M%3BSimpson%2C+R+T&rft.aulast=Venkatesan&rft.aufirst=M&rft.date=1986-01-01&rft.volume=166&rft.issue=1&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Experimental+Cell+Research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - CONF T1 - Photocarcinogenesis and persistent hyperplasia in UV-irradiated SENCAR mouse skin. AN - 14555000; 1437960 AB - Susceptibility to photocarcinogenesis has been examined in several mouse strains and stocks including SENCAR, CD-1, BALB/c, C3H, C57Bl, and NZB. SENCAR mice are hypersusceptible to tumorigenesis caused by single high dose exposures to ultraviolet (UV) radiation but not by chronic low-dose exposures. SENCAR mice also exhibit an exaggerated and persistent epidermal hyperplasia in response to UV-induced tissue damage. The persistent hyperplasia is apparently due to a sustained proliferation of the epithelial basal cells, rather than to delayed cell differentiation. SENCAR mice did not exhibit persistent hyperplasia following other forms of tissue damage (surgical or thermal). In related studies, the levels of thymine dimers induced in SENCAR epidermis by UV radiation were comparable to those observed in BALB/c epidermis. In addition, no differences were found in the tissue distribution or persistence of thymine dimers in SENCAR and BALB/c skin. JF - Environmental Health Perspectives AU - Strickland, P T Y1 - 1986 PY - 1986 DA - 1986 SP - 131 EP - 134 VL - 68 KW - mice KW - Toxicology Abstracts KW - U.V. radiation KW - carcinogenesis KW - hyperplasia KW - skin KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14555000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Photocarcinogenesis+and+persistent+hyperplasia+in+UV-irradiated+SENCAR+mouse+skin.&rft.au=Strickland%2C+P+T&rft.aulast=Strickland&rft.aufirst=P&rft.date=1986-01-01&rft.volume=68&rft.issue=&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - CONF T1 - Escherichia coli K51 and K93 capsular polysaccharides are cross-reactive with the group A capsular polysaccharide of Neisseria meningitidis : Immunochemical, structural and epidemiological studies. AN - 14535975; 1414557 JF - Antonie Van Leeuwenhoek AU - Guirguis, N AU - Schneerson, R AU - Bax, A AU - Egan, W AU - Robbins, J B AU - Shiloach, J AU - Orskov, I AU - Orskov, F AU - El Kholy, A Y1 - 1986 PY - 1986 DA - 1986 SP - 270 EP - 275 IS - suppl. KW - antigenic relationship KW - cross-reactivity KW - polysaccharides KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Escherichia coli KW - Neisseria meningitidis KW - J 02832:Antigenic properties and virulence KW - F 06008:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14535975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antonie+Van+Leeuwenhoek&rft.atitle=Escherichia+coli+K51+and+K93+capsular+polysaccharides+are+cross-reactive+with+the+group+A+capsular+polysaccharide+of+Neisseria+meningitidis+%3A+Immunochemical%2C+structural+and+epidemiological+studies.&rft.au=Guirguis%2C+N%3BSchneerson%2C+R%3BBax%2C+A%3BEgan%2C+W%3BRobbins%2C+J+B%3BShiloach%2C+J%3BOrskov%2C+I%3BOrskov%2C+F%3BEl+Kholy%2C+A&rft.aulast=Guirguis&rft.aufirst=N&rft.date=1986-01-01&rft.volume=&rft.issue=suppl.&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Antonie+Van+Leeuwenhoek&rft.issn=00036072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Substrate specificity of rat brain calcium-activated and phospholipid-dependent protein kinase. AN - 14523205; 1411575 AB - A synthetic peptide ArgThrProProSerGly with sequence similar to the threonine sites of phosphorylation in both myelin basic protein and simian virus 40 T antigen could be phosphorylated in vitro by a purified rat brain Ca super(2+)-activated and phospholipid-dependent prorein kinase, protein kinase C. The apparent K sub(m) and V sub(m) values of this heptapeptide for the enzyme were determined to be 240 mu M and 60 nmol/min/mg, respectively. Up to 0.8 mol super(32)P could be incorporated into the peptide, mainly at the threonine residue. Substitution of the L-threonine residue in the heptapeptide by its D-enantiomer abolished the phosphorylatability of the peptide by protein kinase C. However, this (D)Thr-containing peptide could act as a competitive inhibitor for the kinase with an apparent K sub(i) value of approximately 320 mu M. JF - Biochemical and Biophysical Research Communications AU - Chan, K-FJ AU - Stoner, G L AU - Hashim, G A AU - Huang, K-P AD - Sect. Metab. Reg., Endocrinol. and Reprod. Branch, NICHD, Natl. Inst. Health, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 1358 EP - 1364 VL - 134 IS - 3 SN - 0006-291X, 0006-291X KW - brain KW - dependent KW - phospholipids KW - protein kinase KW - rats KW - substrate specificity KW - Microbiology Abstracts B: Bacteriology; Calcium & Calcified Tissue Abstracts KW - T 20029:Enzymes KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14523205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Substrate+specificity+of+rat+brain+calcium-activated+and+phospholipid-dependent+protein+kinase.&rft.au=Chan%2C+K-FJ%3BStoner%2C+G+L%3BHashim%2C+G+A%3BHuang%2C+K-P&rft.aulast=Chan&rft.aufirst=K-FJ&rft.date=1986-01-01&rft.volume=134&rft.issue=3&rft.spage=1358&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - phospholipids; brain ER - TY - JOUR T1 - Occupational risk factors for brain tumors. A case referent death-certificate analysis. AN - 14485665; 1376930 AB - Numerous studies have suggested that employment in the oil refining and chemical manufacturing industries may be associated with excess brain tumor risk. A case-referent study was undertaken to evaluate brain tumor risk by occupation and industry in three geographic areas (northern New Jersey, Philadelphia, and the Gulf Coast of Louisiana) with a heavy concentration of these industries. Seven hundred and eighteen white men dying from brain tumor at age 30 years or older were ascertained from death certificates for 1978-1981. The referents were men who died of other causes, excluding epilepsy and stroke. Usual occupation and industry were obtained from the death certificates, and the maximum likelihood estimates of the relative risk were calculated for specific industries and occupations. Small nonsignificant excess risks of brain tumors were seen among persons whose usual employment was in the petroleum refining, electrical equipment manufacturing, health services, and educational services industries. Compared with other white-collar professionals, health diagnosticians, teachers, and artists/designers had a significantly elevated brain tumor risk. JF - Scandinavian Journal of Work, Environment & Health AU - Thomas, T L AU - Fontham, ETH AU - Norman, SA AU - Stemhagen, A AU - Hoover, R N AD - Occup. Stud. Sect., Environ. Epidemiol. Branch, NCI, Landow Build., Room 4C16, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 121 EP - 127 VL - 12 IS - 2 SN - 0355-3140, 0355-3140 KW - tumors KW - Health & Safety Science Abstracts; Pollution Abstracts KW - occupational health KW - refineries KW - chemical industry KW - risk assessment KW - brain KW - H SI6.1:BASIC APPROACHES, CONCEPTS, AND THEORY KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14485665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.atitle=Occupational+risk+factors+for+brain+tumors.+A+case+referent+death-certificate+analysis.&rft.au=Thomas%2C+T+L%3BFontham%2C+ETH%3BNorman%2C+SA%3BStemhagen%2C+A%3BHoover%2C+R+N&rft.aulast=Thomas&rft.aufirst=T&rft.date=1986-01-01&rft.volume=12&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - brain; occupational health; risk assessment; refineries; chemical industry ER - TY - JOUR T1 - Disposition of o-benzyl-p-chlorophenol in male rats. AN - 14471481; 1373278 AB - The disposition and metabolism of o-benzyl-p-chlorophenol (BCP) were studied in male Fischer-344 rats. Three days after oral administration of ( super(14)C)BCP at 10, 100, or 1000 mg/kg, more than 90% of each dose was excreted in urine and feces. Comparison of disposition after intravenous, dermal, or oral administraton indicated that BCP was not completely absorbed from the gastrointestinal tract or skin. Biliary excretion of BCP was dose-dependent, with proportionally less BCP-derived radioactivity being excreted in the bile as the dose was raised. The results also indicated that enterophepatic circulation was involved in BCP disposition. The major in vivo metabolites were glucuronyl conjugates of BCP and hydroxy-BCP. Glutathione conjugates were also present in urine. JF - Journal of Toxicology and Environmental Health AU - Kao, L R AU - Birnbaum, L S AD - NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 441 EP - 458 VL - 18 IS - 3 SN - 0093-4108, 0093-4108 KW - metabolism KW - chlorophene KW - rats KW - Toxicology Abstracts KW - disinfectants KW - disposition KW - X 24140:Cosmetics, toiletries & household products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14471481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=Disposition+of+o-benzyl-p-chlorophenol+in+male+rats.&rft.au=Kao%2C+L+R%3BBirnbaum%2C+L+S&rft.aulast=Kao&rft.aufirst=L&rft.date=1986-01-01&rft.volume=18&rft.issue=3&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - disinfectants; disposition ER - TY - JOUR T1 - Influence of dietary zinc on di(2-ethylhexyl)phthalate-induced testicular atrophy and zinc depletion in adult rats. AN - 14447415; 1356092 AB - Groups of 48 adult male F344 rats were maintained on synthetic diets containing 20 ppm (normal), 2 ppm (low), or 200 ppm (high) zinc. After 1 week of acclimation to the various diets, groups of 12 rats from each dietary regimen were gavaged for 13 consecutive days with 0.0 (vehicle), 0.33, 1.0, or 3.0 g/kg di(2-ethyl-hexyl)phthalate (DEHP). These were selected as relatively nontoxic, mildly toxic, and moderately toxic doses for producing testicular injury in adult male rats. At termination on the 14th day, body weight gain was reduced by 3.0 g/kg DEHP dose in the normal and low-zinc diet groups but not in the high-zinc diet groups. JF - Toxicology and Applied Pharmacology AU - Agarwal, D K AU - Eustis, S AU - Lamb, JC IV AU - Jameson, C W AU - Kluwe, WM AD - NTP/NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 12 EP - 24 VL - 84 IS - 1 SN - 0041-008X, 0041-008X KW - atrophy KW - effects on KW - zinc KW - bis(2-ethylhexyl) phthalate KW - rats KW - Toxicology Abstracts KW - seminal vesicle KW - prostate KW - testes KW - X 24120:Food, additives & contaminants KW - X 24162:Chronic exposure KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14447415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Influence+of+dietary+zinc+on+di%282-ethylhexyl%29phthalate-induced+testicular+atrophy+and+zinc+depletion+in+adult+rats.&rft.au=Agarwal%2C+D+K%3BEustis%2C+S%3BLamb%2C+JC+IV%3BJameson%2C+C+W%3BKluwe%2C+WM&rft.aulast=Agarwal&rft.aufirst=D&rft.date=1986-01-01&rft.volume=84&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - testes; seminal vesicle; prostate ER - TY - JOUR T1 - Effects of acetaminophen on cadmium metabolism in mice. AN - 14444715; 1342187 AB - Acetaminophen (ACM) administration to mice of the (C57BL/6 x DBA/2)F sub(1) strain produced a typical hepatic centrilobular necrosis similar to that observed in rodents and humans. To determine the effects of this drug-induced necrosis on cadmimum (Cd) metabolism, mice were given a sublethal dose of CdCl sub(2) multiplied by 2.5 H sub(2)O containing super(109CdCl)d2 and maintained for a period of time sufficient for Cd-metallothionein (Cd-MT) to be synthesized and distributed. Subsequent administration of ACM ip or po evoked a marked redistribution of Cd from livers to kidneys of mice, and increased the amount of Cd excreted in urine and feces. The effect of ACM on Cd redistribution was antagonized by administration of cysteine, a glutathione precursor, and was enhanced by pretreatment with phenobarbital, a potent inducer of the cytochrome P-450 mixed-function oxidase system. Cd excreted in urine was predominantly in a low-molecular-weight form, but there was evidence of two minor components of higher molecular weight, neither of which eluted as Cd-MT. Cd excreted in feces was insoluble following homogenization in 0.25 M sucrose solution. Cd in livers and kidneys of ACM-treated mice eluted as Cd-MT. It was concluded that persons who have a moderately high Cd burden may be at risk of Cd nephrotoxicity if they incur hepatic necrosis subsequent to ACM abuse. JF - Toxicology and Applied Pharmacology AU - Gale, G R AU - Atkins, L M AU - Smith, AB AU - Walker, EM Jr AU - Fody, E P AD - NCI, Med. Cent., 109 Bee St., Charleston, SC 29403, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 368 EP - 377 VL - 82 IS - 2 SN - 0041-008X, 0041-008X KW - effects on KW - acetaminophen KW - cadmium KW - mice KW - Toxicology Abstracts KW - metabolism KW - analgesics KW - X 24114:Metabolism KW - X 24163:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14444715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Effects+of+acetaminophen+on+cadmium+metabolism+in+mice.&rft.au=Gale%2C+G+R%3BAtkins%2C+L+M%3BSmith%2C+AB%3BWalker%2C+EM+Jr%3BFody%2C+E+P&rft.aulast=Gale&rft.aufirst=G&rft.date=1986-01-01&rft.volume=82&rft.issue=2&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - analgesics; metabolism ER - TY - JOUR T1 - Partitioning of renal zinc between metallothionein and ethylene-diaminetetraacetic acid (EDTA) after treatment of rats with Ca(Na) sub(2)EDTA. AN - 14436665; 1354903 AB - Calcium disodium edtate (EDTA) is a widely used chelator in the treatment of lead poisoning, although it also mobilizes, other trace metals such as zinc. The authors have found that daily injection of 400 mg EDTA/kg body wt ip to rats results in an increase in the concentration of zinc (Zn) in the kidney when measured by atomic absorption spectroscopy. This increase is not associated with an induction of metal-lothionein (MT), a protein normally involved in the homeostasis of zinc. In fact, separation of kidney homogenate on a column of Sephadex G-75 demonstrates that virtually no Zn-MT remains in the kidney 24 hr after an EDTA injection, although after 3 days, Zn-MT levels appear to return to normal. Instead, increased renal Zn is found associated with residual EDTA. False high measurements of MT can be obtained from the Cd-saturation/hemoglobin assay due to the presence of residual EDTA in the kidney. Although nearly all of an injected dose or radiolabeled EDTA is rapidly excreted, O.2 to 0.1% is retained in the kidney 1 day later; this is sufficient to account for the additional Zn. JF - Toxicology and Applied Pharmacology AU - Miller, C R AU - Zhu, S-Y AU - Victery, W AU - Goyer, R A AD - NIEHS, Mail Drop D4-01, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 584 EP - 592 VL - 84 IS - 3 SN - 0041-008X, 0041-008X KW - EDTA KW - metallothionein KW - zinc KW - rats KW - Toxicology Abstracts KW - chelating agents KW - kidney KW - X 24163:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14436665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Partitioning+of+renal+zinc+between+metallothionein+and+ethylene-diaminetetraacetic+acid+%28EDTA%29+after+treatment+of+rats+with+Ca%28Na%29+sub%282%29EDTA.&rft.au=Miller%2C+C+R%3BZhu%2C+S-Y%3BVictery%2C+W%3BGoyer%2C+R+A&rft.aulast=Miller&rft.aufirst=C&rft.date=1986-01-01&rft.volume=84&rft.issue=3&rft.spage=584&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - kidney; chelating agents ER - TY - JOUR T1 - A silver stain for the rapid quantitative detection of proteins or nucleic acids on membranes or thin layer plates. AN - 14434641; 1353010 AB - A relatively simple silver stain which takes less than 15 min to perform has been developed for the detection of nanogram quantities of proteins and DNA on cellulose membranes and thin layer plates. This stain demonstrates a reproducible curvilinear relationship between silver density and the amount of protein or DNA, over an averaged concentration range from 1 to 300 ng for proteins and 10 to 710 ng for DNA. The ease of staining proteins and DNA on membranes, combined with the stain's sensitivity and reproducibility, permits the use of this procedure for the quantitative determination of nanogram amounts of proteins and DNA. The simplicity of this silver stain has also permitted a survey of the staining properties of individual amino acids, purine and pyrimidine bases, nucleosides, nucleotides, homopolymers, and small peptides of known sequence. JF - Analytical Biochemistry AU - Merril, C R AU - Pratt, ME AD - Sect. Biochem. Genet., Clin. Neurogenet. Branch, NIMH, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 96 EP - 110 VL - 156 IS - 1 SN - 0003-2697, 0003-2697 KW - cellulose KW - membranes KW - nucleic acids KW - proteins KW - silver KW - staining KW - thin-layer chromatography KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - N 14610:Occurrence, isolation & assay KW - W 30550:Others KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14434641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=A+silver+stain+for+the+rapid+quantitative+detection+of+proteins+or+nucleic+acids+on+membranes+or+thin+layer+plates.&rft.au=Merril%2C+C+R%3BPratt%2C+ME&rft.aulast=Merril&rft.aufirst=C&rft.date=1986-01-01&rft.volume=156&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - thin-layer chromatography; staining; proteins ER - TY - JOUR T1 - Effect of dietary zinc deficiency on the accumulation of cadmium and metallothionein in selected tissues of the rat. AN - 14432727; 1343022 AB - The effect of continuous dietary zinc deficiency on the metabolism of the toxic heavy metal cadmium has not been widely studied. The zinc-deficient diet resulted in an approximately 40% reduction in plasma zinc (assessed at 3, 6, and 9 wk) in the absence of overt signs of zinc deficiency (i.e., reduced weight gain, alopecia, etc.). Separate groups of rats were also maintained on zinc-defined diets for a total of 9 wk, but cadmium was added to the diet (0, 12.5, 25, 50, 100, and 200 ppm) at the end of wk 3 and maintained at that level throughout the remaining 6 wk of the study, when the rats were killed. The feeding of the zinc-deficient diet markedly enhanced the accumulation of cadmium in the liver, kidney, and testes. JF - Journal of Toxicology and Environmental Health AU - Waalkes, M P AD - NCI-FCRF, Build. 538, Rm. 226, Frederick, MD 21701, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 301 EP - 313 VL - 18 IS - 2 SN - 0093-4108, 0093-4108 KW - deficiency KW - organs KW - zinc KW - cadmium KW - metallothionein KW - rats KW - Toxicology Abstracts KW - X 24163:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14432727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=Effect+of+dietary+zinc+deficiency+on+the+accumulation+of+cadmium+and+metallothionein+in+selected+tissues+of+the+rat.&rft.au=Waalkes%2C+M+P&rft.aulast=Waalkes&rft.aufirst=M&rft.date=1986-01-01&rft.volume=18&rft.issue=2&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Sizing and separation of liposomes, biological vesicles, and viruses by high-performance liquid chromatography. AN - 14431726; 1351205 AB - The ability of an HPLC gel exclusion column (TSK G6000PW) to separate lipid vesicles, viruses, and biological vesicles according to size was tested and compared with separations on Sephacryl S1000. The columns were calibrated using vesicular Stokes radii determined by quasi-elastic light scattering. The vesicles separated according to size on both types of column and remained intact during elution. Viruses of known diameters and clathrin-coated vesicles were also eluted as a function of size. The TSK G6000PW column was able to separate larger particles (> 500 nm) than the Sephacryl S1000, and, when used in combination with the TSK G5000PW column, gave more discrete separations of smaller particles (10 to 30 nm diameter). Moreover, the HPLC columns can be run significantly faster (10-20 min vs several hours) and give more precise results than Sephacryl S1000. JF - Analytical Biochemistry AU - Ollivon, M AU - Walter, A AU - Blumenthal, R AD - Sect. Membrane Struct. and Funct., LTB, NCI, Natl. Inst. Health, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 262 EP - 274 VL - 152 IS - 2 SN - 0003-2697, 0003-2697 KW - separation KW - size KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - liposomes KW - membrane vesicles KW - viruses KW - high-performance liquid chromatography KW - A 01114:Viruses KW - V 22033:Other components & the virion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14431726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=Sizing+and+separation+of+liposomes%2C+biological+vesicles%2C+and+viruses+by+high-performance+liquid+chromatography.&rft.au=Ollivon%2C+M%3BWalter%2C+A%3BBlumenthal%2C+R&rft.aulast=Ollivon&rft.aufirst=M&rft.date=1986-01-01&rft.volume=152&rft.issue=2&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - viruses; liposomes; membrane vesicles; high-performance liquid chromatography ER - TY - JOUR T1 - A eukaryotic vector for the expression of genes or gene fragments. AN - 14428112; 1326309 AB - The eukaryotic vector described is useful for the expression of foreign genes or gene fragments. In the case of gene fragments that lack their own initiation codon, this vector provides an initiation condon (ATG), and the product is made as a fusion protein of T-antigen (10-11 amino acids from the amino terminal region of T-antigen). Some useful features of this vector are: 1) it replicates in bacterial and mammalian cells; 2) it provides splice and polyadenylation signals: 3) it provides initiation codon (ATG) for gene fragments that lack them. JF - GENE ANAL. TECH. AU - Shyam, E AU - Reddy, P AU - Rao, V N AD - Program Resources, Inc., NCI-Frederick Cancer Res. Facil., Build. 469, Frederick, MD 21701, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 41 EP - 44 VL - 3 IS - 3 KW - fragments KW - antigen T KW - SV40 KW - cloning vectors KW - eukaryotes KW - gene fusion KW - genes KW - plasmids KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - N 14682:Cloning vectors KW - W 30114:Cloning vectors KW - G 07120:Recombinant DNA/Genetic engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14428112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=GENE+ANAL.+TECH.&rft.atitle=A+eukaryotic+vector+for+the+expression+of+genes+or+gene+fragments.&rft.au=Shyam%2C+E%3BReddy%2C+P%3BRao%2C+V+N&rft.aulast=Shyam&rft.aufirst=E&rft.date=1986-01-01&rft.volume=3&rft.issue=3&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=GENE+ANAL.+TECH.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - cloning vectors; eukaryotes; genes; gene fusion; plasmids ER - TY - JOUR T1 - Urogenital challenge of primate species with Mycoplasma genitalium and characteristics of infection induced in chimpanzees. AN - 14411962; 1258864 AB - Eighteen male and eight female primates, representing five species, were inoculated urogenitally with Mycoplasma genitalium from men with nongonococcal urethritis. Male Macaca mulatta and Macaca fascicularis were resistant. Female Saimiri sciureus and Saguinus mystax exhibited low-level, genital-tract infections. Male Pan troglodytes developed an obvious genital-tract infection, with some shedding organisms for 21 weeks. M. genitalium was recovered from the blood of two male chimpanzees. Female chimpanzees shed organisms 12-15 weeks. Chimpanzees colonized with the organism exhibited increased numbers of polymorphonuclear leukocytes in the genital tract and developed a significant antibody response, giving evidence for the pathogenicity of M. genitalium . JF - Journal of Infectious Diseases AU - Tully, J G AU - Taylor-Robinson, D AU - Rose, D L AU - Furr, P M AU - Graham, CE AU - Barile, M F AD - Mycoplasma Sect., NIAID, Build. 550, Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 1046 EP - 1054 VL - 153 IS - 6 SN - 0022-1899, 0022-1899 KW - experimental infection KW - clinical isolates KW - infection KW - leukocytes (polymorphonuclear) KW - antibody response KW - monkeys KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - genitourinary tract KW - Mycoplasma genitalium KW - non-specific urethritis KW - Pan troglodytes KW - J 02847:Genitourinary tract KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14411962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Urogenital+challenge+of+primate+species+with+Mycoplasma+genitalium+and+characteristics+of+infection+induced+in+chimpanzees.&rft.au=Tully%2C+J+G%3BTaylor-Robinson%2C+D%3BRose%2C+D+L%3BFurr%2C+P+M%3BGraham%2C+CE%3BBarile%2C+M+F&rft.aulast=Tully&rft.aufirst=J&rft.date=1986-01-01&rft.volume=153&rft.issue=6&rft.spage=1046&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Mycoplasma genitalium; Pan troglodytes; genitourinary tract; non-specific urethritis ER - TY - JOUR T1 - Purification and kinetic properties of ox brain histamine N-methyltransferase. AN - 14407837; 1313628 AB - Histamine N-methyltransferase was purified 1100-fold from ox brain. The native enzyme has an M sub(r) of 34,800 plus or minus 2,400 as measured by gel filtration on Sephadex G-100. The enzyme is highly specific for histamine. It does not methylate noradrenaline, adrenaline, DL-3,4-dihydroxymandelic acid, 3,4-dihydroxphenylacetic acid, 3-hydroxytyramine or imidazole-4-acetic acid. Unlike the enzyme from rat and mouse brain, ox brain histamine N-methyltransferase did not exhibit substrate inhibition by histamine. Initial rate and product inhibition studies were consistent with an ordered steady-state mechanism with S-adenosylmethionine being the first substrate to bind to the enzyme and N-methylhistamine being the first product to dissociate. JF - Biochemical Journal AU - Gitomer, W L AU - Tipton, K AD - Lab. Metab., NIAAA, 12501 Washington Ave., Rockville, MD 20852, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 669 EP - 676 VL - 233 IS - 3 SN - 0264-6021, 0264-6021 KW - brain KW - cattle KW - histamine methyltransferase KW - inhibition KW - kinetics KW - methionine KW - methylhistamine KW - purification KW - substrate specificity KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - N3 11070:Neurochemistry and cellular biology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14407837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Journal&rft.atitle=Purification+and+kinetic+properties+of+ox+brain+histamine+N-methyltransferase.&rft.au=Gitomer%2C+W+L%3BTipton%2C+K&rft.aulast=Gitomer&rft.aufirst=W&rft.date=1986-01-01&rft.volume=233&rft.issue=3&rft.spage=669&rft.isbn=&rft.btitle=&rft.title=Biochemical+Journal&rft.issn=02646021&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - substrate specificity; brain ER - TY - JOUR T1 - Brain tumors and occupational risk factors.Aa review. AN - 14403028; 1315351 AB - Little is known about the etiology of tumors of the brain and central nervous system (CNS); epidemiologic studies have indicated recently that excess brain and CNS tumor risk may be associated with employment in certain occupations or industries. Some studies have shown that certain white-collar professional groups (eg, artists, laboratory professionals, veterinarians, embalmers) appear to have an elevated risk of brain tumors, and they raise the issue of a diagnostic sensitivity bias. Some blue-collar occupational groups, including rubber workers, oil refinery workers, chemical plant workers, polyvinyl chloride workers, machinists, and others, have been reported to have an elevated risk of brain tumors. Most of these workers are potentially exposed to multiple chemicals; nevertheless they have some exposures in common, for example, exposure to organic solvents, lubricating oil, acrylonitrile and vinyl chloride, formaldehyde, polycyclic aromatic hydrocarbons, and phenolic compounds. JF - Scandinavian Journal of Work, Environment & Health AU - Thomas, T L AU - Waxweiler, R J AD - Occup. Stud. Sect., Environ. Epidemiol. Branch, NCI, Landow Build., Rm. 4C16, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 1 EP - 15 VL - 12 IS - 1 SN - 0355-3140, 0355-3140 KW - tumors KW - acrylonitrile KW - Health & Safety Science Abstracts; Pollution Abstracts KW - etiology KW - occupational health KW - solvents KW - aromatic compounds KW - formaldehyde KW - polycyclic aromatic hydrocarbons KW - risk assessment KW - H SI0.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14403028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.atitle=Brain+tumors+and+occupational+risk+factors.Aa+review.&rft.au=Thomas%2C+T+L%3BWaxweiler%2C+R+J&rft.aulast=Thomas&rft.aufirst=T&rft.date=1986-01-01&rft.volume=12&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - etiology; risk assessment; solvents; formaldehyde; polycyclic aromatic hydrocarbons; aromatic compounds; occupational health ER - TY - JOUR T1 - Longitudinal evaluation of pulmonary function in copper smelter workers exposed to sulfur dioxide. AN - 14399746; 1246291 AB - From 1973 to 1974, a longitudinal study of pulmonary function in 113 Utah copper smelter workers reported significant declines in FVC and FEV sub(1) related to sulfur dioxide exposure. In 1980, the authors performed a 7-yr follow-up study, finding significant increases in FVC and FEV sub(1). Subgroups of smelter workers with initial higher exposures to sulfur dioxide and FEV sub(1) < 90% predicted did not show an accelerated rate of decline. To reconcile these differences between the 2 studies, they reevaluated the spirometry curves from 1973 and 1974. All had short expiratory times, with none 6 s or longer, whereas all of the curves from the spirograms obtained in 1980 exceeded 6 s. In addition, from 1980 to 1983, they performed a longitudinal study of 48 of the original workers, finding small annual mean declines for FVC of 6 ml and FEV sub(1), of 5 ml. Personal exposures to sulfur dioxide were not significantly different in 1982 than in 1976; thus, they were unable to corroborate the findings of the initial longitudinal study. JF - American Journal of Respiratory and Critical Care Medicine AU - Rom, W N AU - Wood, S D AU - White, G L AU - Bang, K M AU - Reading, J C AD - Pulm. Branch, Rm. 6D-09, Build. 10, NHLBI-NIH, Bethesda, MD 20892, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 830 EP - 833 VL - 133 IS - 5 SN - 0003-0805, 0003-0805 KW - chronic exposure KW - man KW - sulfur dioxide KW - copper KW - respiratory pathology KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - toxicology KW - occupational exposure KW - P 0000:AIR POLLUTION KW - H SM9.31:INHALATION INJURIES KW - H SI0.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14399746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Longitudinal+evaluation+of+pulmonary+function+in+copper+smelter+workers+exposed+to+sulfur+dioxide.&rft.au=Rom%2C+W+N%3BWood%2C+S+D%3BWhite%2C+G+L%3BBang%2C+K+M%3BReading%2C+J+C&rft.aulast=Rom&rft.aufirst=W&rft.date=1986-01-01&rft.volume=133&rft.issue=5&rft.spage=830&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - sulfur dioxide; occupational exposure; copper; toxicology; respiratory pathology; man ER - TY - JOUR T1 - Effects of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) on lactation in rats. AN - 14389736; 1246254 AB - An inverse correlation between the concentration of DDE in human breast milk samples and the duration of breast feeding prompted the present study of the effects of DDE administration on the lactational performance of primiparous rats. Daily doses of 10 mg p,p'-DDE/kg body weight were given to virgin female Sprague-Dawley rats 5 d/wk for 5 wk prior to mating and continued throughout the gestation and lactation periods. No significant differences between DDE-treated and control groups were observed for any of the lactation parameters, even though the concentration of DDE in the milk of treated rats was approximately two orders of magnitude grater than the upper range of the DDE levels measured in human milk samples. JF - Journal of Toxicology and Environmental Health AU - Kornbrust, D AU - Gillis, B AU - Collins, B AU - Goehl, T AU - Gupta, B AU - Schwetz, B AD - NIEHS, D4-02, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 23 EP - 36 VL - 17 IS - 1 SN - 0093-4108, 0093-4108 KW - effects on KW - mammary milk KW - lactation KW - pesticides (organochlorine) KW - rats KW - DDE KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - toxicity KW - insecticides KW - breast milk KW - organochlorine compounds KW - H SE5.20:INSECTICIDES KW - X 24132:Chronic exposure KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14389736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=Effects+of+1%2C1-dichloro-2%2C2-bis%28p-chlorophenyl%29ethylene+%28DDE%29+on+lactation+in+rats.&rft.au=Kornbrust%2C+D%3BGillis%2C+B%3BCollins%2C+B%3BGoehl%2C+T%3BGupta%2C+B%3BSchwetz%2C+B&rft.aulast=Kornbrust&rft.aufirst=D&rft.date=1986-01-01&rft.volume=17&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - rats; DDE; breast milk; organochlorine compounds; toxicity; insecticides; lactation ER - TY - JOUR T1 - Micro-BIA, a colorimetric microtiter assay of lambda prophage induction. AN - 14384561; 1242557 AB - Escherichia coli that are lysogenic for a lambda -lacZ fusion phage produce beta -galactosidase, product of the lacZ gene, upon induction of the prophage by DNA-damaging agents. The miniaturization of a quantitative, colorimetric beta -galactosidase (prophage) induction assay (BIA) is presented. Induction asays are performed in microtiter wells with the aid of multichannel pipetting devices. Results are shown with screening strain BR513 (uvrB Delta envA ) and a strain, BR339 (uvrB Delta lexA 3ind super(-)) which exhibits enhanced induction. A method developed for strain BR339 utilizes bacteria stored frozen in log phase, permeabilized in vitro, and used immediately; with this method, 2 consecutive assays may be completed in 1 working day. Mutagens utilized for the model studies included 4NQO, ENNG, daunorubicin, bleomycin, acetoxy-AAF, B(a)P, DMBA, and DEN (the last three in the presence of liver S9). Induced levels of beta -galactosidase were monitored using a vertical light path photometer that measured color absorbance in each microtiter well. Considerable savings in labor and materials are achieved with the method described, one which may be used as a screen for DNA-damaging chemicals. JF - Mutation Research AU - Elespuru, R K AU - Moore, S G AD - PRI - Ferment. Program LBI - Basic Res. Program, NCI - Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 31 EP - 40 VL - 164 IS - 1 SN - 0027-5107, 0027-5107 KW - induction KW - assays KW - Genetics Abstracts; Toxicology Abstracts KW - toxicity testing KW - chemicals KW - phage lambda KW - G 07220:General theory/testing systems KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14384561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Micro-BIA%2C+a+colorimetric+microtiter+assay+of+lambda+prophage+induction.&rft.au=Elespuru%2C+R+K%3BMoore%2C+S+G&rft.aulast=Elespuru&rft.aufirst=R&rft.date=1986-01-01&rft.volume=164&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - phage lambda; chemicals; toxicity testing ER - TY - JOUR T1 - Molecular cloning of the intronless EJ ras oncogene using a murine retrovirus shuttle vector. AN - 14353496; 1173199 AB - The authors have inserted a genomic clone of the human EJ bladder oncogene into a murine retrovirus shuttle vector. Contransfection of this shuttle vector DNA containing the activated ras oncogene with molecularly cloned Moloney murine leukemia virus into NIH/3T3 cells was able to rescue a replicating and transforming retrovirus. The viral DNA from infected cells was excided by fusion to mouse COP-5 cells and recloned into Escherichia coli as plasmid DNA. Analysis of the recloned plasmids by size, restriction enzyme mapping, and DNA sequence indicated that approximately 5% of the recloned plasmids contained the intronless EJ ras oncogene. JF - GENE ANAL. TECH. AU - Robins, T AU - Jhappan, C AU - Chirikjian, J AU - Vande Woude, GF AD - LBI-Basic Res. Program, Build. 469, P.O. Box B, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 12 EP - 16 VL - 3 IS - 1 KW - ras gene KW - oncogenes KW - cloning vectors KW - genes KW - man KW - retrovirus KW - transfection KW - urinary bladder KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Virology & AIDS Abstracts KW - V 22050:Viral genetics including virus reactivation KW - G 07120:Recombinant DNA/Genetic engineering KW - W 30122:TRANSFECTION KW - N 14672:Transfection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14353496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=GENE+ANAL.+TECH.&rft.atitle=Molecular+cloning+of+the+intronless+EJ+ras+oncogene+using+a+murine+retrovirus+shuttle+vector.&rft.au=Robins%2C+T%3BJhappan%2C+C%3BChirikjian%2C+J%3BVande+Woude%2C+GF&rft.aulast=Robins&rft.aufirst=T&rft.date=1986-01-01&rft.volume=3&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=GENE+ANAL.+TECH.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - retrovirus; cloning vectors; transfection; man; genes; urinary bladder ER - TY - JOUR T1 - C3 binds preferentially to long-chain lipopolysaccharide during alternative pathway activation by Salmonella montevideo . AN - 14326654; 1155546 AB - In this paper, the authors show that complement activation occurs exclusively on the LPS molecules bearing the longest O-PS chains when a smooth, serum-resistant strain of Salmonella montevideo (SL5222) is incubated in serum. This study provides strong evidence that the O-PS of LPS sterically hinders access of large molecules to the cell surface and indicates that the LPS coat of these bacteria functions as a barrier against large protein molecules. JF - Journal of Immunology AU - Joiner, KA AU - Grossman, N AU - Schemetz, M AU - Leive, L AD - Lab. Clin. Invest., NIAID, Natl. Inst. Health, Build. 10, Rm. 11N-208, Bethesda, MD 20205, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 710 EP - 715 VL - 136 IS - 2 SN - 0022-1767, 0022-1767 KW - binding KW - activation KW - Salmonella montevideo KW - complement component C3 KW - lipopolysaccharides KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - alternative pathway KW - F 06087:Function KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14326654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=C3+binds+preferentially+to+long-chain+lipopolysaccharide+during+alternative+pathway+activation+by+Salmonella+montevideo+.&rft.au=Joiner%2C+KA%3BGrossman%2C+N%3BSchemetz%2C+M%3BLeive%2C+L&rft.aulast=Joiner&rft.aufirst=KA&rft.date=1986-01-01&rft.volume=136&rft.issue=2&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - alternative pathway ER - TY - JOUR T1 - Ethanol does not modify opiate-mediated inhibition of striatal adenylate cyclase. AN - 14320478; 1148642 AB - Ethanol increases the activity of "basal." guanine nucleotide- and dopamine-stimulated adenylate cyclase in mouse striatum. In contrast, ethanol, in vitro, did not modify the inhibition of striatal adenylate cyclase activity by opiates (morphine or (D-Ala super(2), D-Leu super(5)) enkephalin). Following chronic in vivo ethanol treatment of mice, there was also no change in the character of opiate inhibition of striatal adenylate cyclase activity. The results suggest that the changes in affinity detected by ligand binding studies are not relevant for receptor-coupled adenylate cyclase activity, or that opiate receptor binding and opiate regulation of adenylate cyclase can be modulated independently. JF - Journal of Neurochemistry AU - Hoffman, P L AU - Tabakoff, B AD - NIAAA/LSNAP, 12501 Washington Ave., Rockville, MD 20852, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 812 EP - 816 VL - 46 IS - 3 SN - 0022-3042, 0022-3042 KW - effects on KW - mediation KW - inhibition KW - activity KW - ethanol KW - adenylate cyclase KW - mice KW - neostriatum KW - opiates KW - Toxicology Abstracts; Biochemistry Abstracts 1: Biological Membranes (till 1993); CSA Neurosciences Abstracts KW - N3 11070:Neurochemistry and cellular biology KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14320478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Ethanol+does+not+modify+opiate-mediated+inhibition+of+striatal+adenylate+cyclase.&rft.au=Hoffman%2C+P+L%3BTabakoff%2C+B&rft.aulast=Hoffman&rft.aufirst=P&rft.date=1986-01-01&rft.volume=46&rft.issue=3&rft.spage=812&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - opiates; neostriatum ER - TY - JOUR T1 - Rapid purification of bacterially expressed fusion proteins by high-performance liquid chromatography methods. AN - 14305035; 1140945 AB - Recent developments in recombinant DNA technology allow the high-level expression in bacteria of substantial amounts of viral and eukaryotic proteins whose genes have been cloned into plasmids. The present study reports two high-performance liquid chromatography (HPLC) methods for the rapid purification to apparent homogeneity of these bacterially expressed proteins. The two methods are anion exchange HPLC in the presence of 7 M Urea and reverse-phase HPLC of protein solubilized by 7.0 M guanidine hydrochloride. JF - GENE ANAL. TECH. AU - DuBois, G C AD - Program Resour., Inc., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1986 PY - 1986 DA - 1986 SP - 6 EP - 11 VL - 3 IS - 1 KW - bacteria KW - gene expression KW - high-performance liquid chromatography KW - proteins KW - purification KW - recombination KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - A 01002:Acids, amino acids, peptides & proteins KW - G 07120:Recombinant DNA/Genetic engineering KW - N 14684:Expression of cloned genes KW - J 02727:Amino acids, peptides and proteins KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14305035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=GENE+ANAL.+TECH.&rft.atitle=Rapid+purification+of+bacterially+expressed+fusion+proteins+by+high-performance+liquid+chromatography+methods.&rft.au=DuBois%2C+G+C&rft.aulast=DuBois&rft.aufirst=G&rft.date=1986-01-01&rft.volume=3&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=GENE+ANAL.+TECH.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - recombination; bacteria; gene expression; high-performance liquid chromatography; proteins ER - TY - JOUR T1 - On site production of chlorine AN - 13802811; 198700849 AB - On site generation of chlorine, at a rate balanced with the chemical consumption, was used particularly in environments where storage was difficult and bulk supply uncertain. The most common method of on site production was the electrolysis of brine solutions to give sodium hypochlorite. Various design factors had to be considered to achieve an optimal balance between plant hardware, process complexity and operational cost. Feedstock quality affected the selection of the type of electrolysis cells to be adopted, dependent on the suitability of direct electrolysis or electrolysis after sodium chloride enrichment. Temperature affected the ionic mobility in the same manner as salinity, with lower voltages giving more efficient operation at higher temperatures and reduced electrode erosion. The strength of hypochlorite was determined by the process economics, with reactions also affected by temperature and pH. A single pass, flow through system in which electrolysis progressed in stages was superior to a single batch or recycle process. Cell design was principally determined by economic considerations. Production of hypochlorite from seawater was the most widespread use of electrochlorination. The design of a seawater electrolysis cell is illustrated. JF - International Power Generation AU - Hobbs, A AD - Kennicott, NEI-Thompson Ltd., Wolverhampton Y1 - 1986 PY - 1986 DA - 1986 SP - 23 EP - 24,26 VL - 9 IS - 7 KW - Sea water (see also marine -----) KW - Aqualine Abstracts KW - AQ 00004:Water Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13802811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Power+Generation&rft.atitle=On+site+production+of+chlorine&rft.au=Hobbs%2C+A&rft.aulast=Hobbs&rft.aufirst=A&rft.date=1986-01-01&rft.volume=9&rft.issue=7&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=International+Power+Generation&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Water treatment for power plant; the problems assessed AN - 13798852; S198824161 AB - Raw water composition may result in difficulties in process treatment because of the presence of undissolved suspended material, dissolved minerals and gases, and dissolved organic material. The sources of these problems and the equipment and processes available for treatment of each are briefly reviewed. Suspended material may be removed by membrane processes, precoat filtration, microstrainers, cartridge filters, media filters, settlement, thickeners, cake presses or chemical conditioning. Dissolved material is generally best removed by ion exchange, reverse osmosis, distillation or electrodialysis. Assessment of systems available for water treatment should be made carefully to achieve effectiveness and efficiency. JF - International Power Generation AU - Hebbs, A AD - Kennicott, NEI-Thompson Ltd., Wolverhampton Y1 - 1986 PY - 1986 DA - 1986 SP - 23 EP - 24,26 VL - 9 IS - 3 KW - Equipment KW - Media KW - Suspended KW - Filters (see also packed columns, groups below) KW - Aqualine Abstracts KW - AQ 00004:Water Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13798852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Power+Generation&rft.atitle=Water+treatment+for+power+plant%3B+the+problems+assessed&rft.au=Hebbs%2C+A&rft.aulast=Hebbs&rft.aufirst=A&rft.date=1986-01-01&rft.volume=9&rft.issue=3&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=International+Power+Generation&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Case Study. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Ergonomic Design Considerations for Ultrasound Real-Time Scanners AN - 21149635; 11625047 AB - The existing design of ultrasound real-time scanners is not satisfactory from the standpoint of operator comfort or efficient use. As currently configured, these units are cumbersome and fatiguing to use and require unnecessarily complex and time-consuming movements on the part of the operator. Redesigning ultrasound scanners so that they conform to accepted principles of ergonomics or human-factor engineering should make it possible to achieve increased efficiency and improved study quality. JF - Journal of Diagnostic Medical Sonography AU - Shawker, Thomas H AU - Russell, Mary Ann AD - Diagnostic Radiology Department, Building 10, Room 1C660, National Institutes of Health, Bethesda, MD 20205 Y1 - 1985/11// PY - 1985 DA - Nov 1985 SP - 251 EP - 254 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 1 IS - 6 SN - 8756-4793, 8756-4793 KW - Biotechnology and Bioengineering Abstracts KW - ultrasonic diagnosis KW - ultrasonics KW - human engineering KW - biomedical engineering KW - equipment design KW - man-machine systems KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21149635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Diagnostic+Medical+Sonography&rft.atitle=Ergonomic+Design+Considerations+for+Ultrasound+Real-Time+Scanners&rft.au=Shawker%2C+Thomas+H%3BRussell%2C+Mary+Ann&rft.aulast=Shawker&rft.aufirst=Thomas&rft.date=1985-11-01&rft.volume=1&rft.issue=6&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Journal+of+Diagnostic+Medical+Sonography&rft.issn=87564793&rft_id=info:doi/10.1177%2F875647938500100603 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Ultrasound DO - http://dx.doi.org/10.1177/875647938500100603 ER - TY - JOUR T1 - Differential neurochemical effects of chronic exposure of cerebral cortical cell culture to valproic acid, diazepam, or ethosuximide. AN - 76730131; 3939744 AB - We have assessed the relative neurochemical effects of valproic acid, ethosuximide, and diazepam on dissociated cultures of mouse cerebral cortex. Cultures were exposed chronically (11 days) to each antiepileptic drug and assayed for number of neurons, total protein, tetanus toxin fixation, high-affinity uptake of gamma-aminobutyric acid and beta-alanine, choline acetyltransferase activity, and specific and clonazepam-displaceable benzodiazepine binding. Ethosuximide-exposed cultures did not evidence neuronal toxicity; exposure to valproic acid and diazepam resulted in modest neuronal toxicity. However, exposure to each of these drugs resulted in a marked reduction in benzodiazepine binding. This effect may relate to a common mechanism of action of drugs used to treat absence seizures. JF - Pediatric neurology AU - Sher, P K AU - Neale, E A AU - Graubard, B I AU - Habig, W H AU - Fitzgerald, S C AU - Nelson, P G AD - Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, MD. PY - 1985 SP - 232 EP - 237 VL - 1 IS - 4 SN - 0887-8994, 0887-8994 KW - Ethosuximide KW - 5SEH9X1D1D KW - Valproic Acid KW - 614OI1Z5WI KW - Diazepam KW - Q3JTX2Q7TU KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Neurons -- drug effects KW - Mice KW - Cerebral Cortex -- drug effects KW - Diazepam -- toxicity KW - Ethosuximide -- toxicity KW - Valproic Acid -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76730131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+neurology&rft.atitle=Differential+neurochemical+effects+of+chronic+exposure+of+cerebral+cortical+cell+culture+to+valproic+acid%2C+diazepam%2C+or+ethosuximide.&rft.au=Sher%2C+P+K%3BNeale%2C+E+A%3BGraubard%2C+B+I%3BHabig%2C+W+H%3BFitzgerald%2C+S+C%3BNelson%2C+P+G&rft.aulast=Sher&rft.aufirst=P&rft.date=1985-07-01&rft.volume=1&rft.issue=4&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Pediatric+neurology&rft.issn=08878994&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-23 N1 - Date created - 1989-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The Multimurinus coral fauna from the Xiuzhumuqinqi District of Inner Mongolia AN - 50362584; 1986-044277 JF - Gushengwu Xuebao = Acta Palaeontologica Sinica AU - Zhao, Jia-ming AU - Yang, Dao-rong Y1 - 1985/07// PY - 1985 DA - July 1985 SP - 440 EP - 448 PB - Science Press, Beijing VL - 24 IS - 4 SN - 0001-6616, 0001-6616 KW - Far East KW - Amplexocarinia crassitheca KW - Lower Permian KW - Multimurinus neimongolensis KW - paleontology KW - new taxa KW - Haortumiao Formation KW - Zoantharia KW - Lonsdaleiidae KW - Anthozoa KW - Invertebrata KW - Asia KW - Szechuanophyllum abnormis KW - China KW - Inner Mongolia China KW - Rugosa KW - Houtoumiao KW - Paleozoic KW - Coelenterata KW - Xiuzhumuqinqi District KW - Waagenophyllidae KW - Permian KW - Bayanqingaobao KW - Chusenophyllum intermedium KW - Multimurinus subregularis KW - Cnidaria KW - 10:Invertebrate paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50362584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gushengwu+Xuebao+%3D+Acta+Palaeontologica+Sinica&rft.atitle=The+Multimurinus+coral+fauna+from+the+Xiuzhumuqinqi+District+of+Inner+Mongolia&rft.au=Zhao%2C+Jia-ming%3BYang%2C+Dao-rong&rft.aulast=Zhao&rft.aufirst=Jia-ming&rft.date=1985-07-01&rft.volume=24&rft.issue=4&rft.spage=440&rft.isbn=&rft.btitle=&rft.title=Gushengwu+Xuebao+%3D+Acta+Palaeontologica+Sinica&rft.issn=00016616&rft_id=info:doi/ LA - Chinese DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1986-01-01 N1 - Number of references - 12 N1 - Document feature - illus. incl. 2 plates N1 - Last updated - 2012-06-07 N1 - CODEN - KSWHAT N1 - SubjectsTermNotLitGenreText - Amplexocarinia crassitheca; Anthozoa; Asia; Bayanqingaobao; China; Chusenophyllum intermedium; Cnidaria; Coelenterata; Far East; Haortumiao Formation; Houtoumiao; Inner Mongolia China; Invertebrata; Lonsdaleiidae; Lower Permian; Multimurinus neimongolensis; Multimurinus subregularis; new taxa; paleontology; Paleozoic; Permian; Rugosa; Szechuanophyllum abnormis; Waagenophyllidae; Xiuzhumuqinqi District; Zoantharia ER - TY - JOUR T1 - A possible site of production of the negative endocochlear DC potential. AN - 85162078; pmid-4044417 AB - The scala vestibuli or the scala tympani of guinea pigs was perfused with artificial perilymph containing 1, 5, 10, 20, 30, 40 and 50 mM of potassium chloride in a total concentration of 150 mM with the background composed of sodium chloride. With the perfusion of the scala vestibuli, each concentration failed to alter the magnitude of the negative endocochlear DC potential produced by anoxia or the intravenous injection of 100 mg/kg of body weight of furosemide. With the perfusion of the scala tympani, the negative endocochlear DC potential disappeared precipitously and the maximum output of the cochlear microphonic was severely depressed with concentrations of potassium chloride of 30 mM or greater. The magnitude of the negative endocochlear DC potential appears to be closely related to the maximum output of the cochlear microphonic. These results suggest that the site of production of the negative EP is in the hair cells of the organ of Corti. JF - Hearing Research AU - Komune, S AU - Huangfu, M AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1985 SP - 153 EP - 158 VL - 18 IS - 2 SN - 0378-5955, 0378-5955 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85162078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+Research&rft.atitle=A+possible+site+of+production+of+the+negative+endocochlear+DC+potential.&rft.au=Komune%2C+S%3BHuangfu%2C+M%3BSnow%2C+J+B&rft.aulast=Komune&rft.aufirst=S&rft.date=1985-05-01&rft.volume=18&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Hearing+Research&rft.issn=03785955&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Differential toxicity of chronic exposure to phenytoin, phenobarbital, or carbamazepine in cerebral cortical cell cultures. AN - 76720574; 3880399 AB - The effects of phenytoin (30 micrograms/ml), phenobarbital (64 micrograms/ml), and carbamazepine (24 micrograms/ml) were assessed in cerebral cortical cell cultures. After antiepileptic drug exposure for eleven days, cultures were assayed for total protein, number of neurons, tetanus toxin fixation, high-affinity uptake of gamma-aminobutyric acid and beta-alanine, activity of choline acetyltransferase, and benzodiazepine binding. Carbamazepine-exposed cultures demonstrated minimal effects, whereas highly significant deficits related to generalized toxicity were observed in cultures exposed to phenytoin or phenobarbital. JF - Pediatric neurology AU - Neale, E A AU - Sher, P K AU - Graubard, B I AU - Habig, W H AU - Fitzgerald, S C AU - Nelson, P G AD - Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, MD 20205. PY - 1985 SP - 143 EP - 150 VL - 1 IS - 3 SN - 0887-8994, 0887-8994 KW - Carbamazepine KW - 33CM23913M KW - Phenytoin KW - 6158TKW0C5 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Mice KW - Cerebral Cortex -- drug effects KW - Phenytoin -- toxicity KW - Carbamazepine -- toxicity KW - Phenobarbital -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76720574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+neurology&rft.atitle=Differential+toxicity+of+chronic+exposure+to+phenytoin%2C+phenobarbital%2C+or+carbamazepine+in+cerebral+cortical+cell+cultures.&rft.au=Neale%2C+E+A%3BSher%2C+P+K%3BGraubard%2C+B+I%3BHabig%2C+W+H%3BFitzgerald%2C+S+C%3BNelson%2C+P+G&rft.aulast=Neale&rft.aufirst=E&rft.date=1985-05-01&rft.volume=1&rft.issue=3&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Pediatric+neurology&rft.issn=08878994&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-23 N1 - Date created - 1989-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Immunohistopathology of human olfactory epithelium, nerve and bulb. AN - 85183283; pmid-2580204 AB - The immunohistochemical characteristics of the human olfactory system were (OMP). OMP was detected in the olfactory receptor neurons and processes extending from the olfactory neuroepithelium to the olfactory bulb. The olfactory receptor cells located close to the epithelial surface also contained OMP. In severely degenerate regions, only a few OMP-containing cells were observed. Differences in OMP-staining intensity were noted among the olfactory receptor cells. The thick neuroepithelium. Proliferating olfactory neuroepithelium contained OMP reactive and nonreactive olfactory receptor cells. The presence of OMP reactive and nonreactive olfactory neurons indicates the coexistence of two functionally different phases of olfactory neurons. These findings suggest that continuous cell turnover is occurring in human olfactory neuroepithelium. JF - The Laryngoscope AU - Nakashima, T AU - Kimmelman, C P AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1985 SP - 391 EP - 396 VL - 95 IS - 4 SN - 0023-852X, 0023-852X KW - Fetus KW - Human KW - Animal KW - Aged KW - Histocytochemistry KW - Nerve Tissue Proteins KW - Rats KW - Epithelial Cells KW - Neurons KW - Adult KW - Middle Age KW - Epithelium KW - Olfactory Bulb KW - Staining and Labeling KW - Male KW - Immunoenzyme Techniques KW - Female KW - Olfactory Mucosa KW - Cell Division KW - Olfactory Nerve UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85183283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Immunohistopathology+of+human+olfactory+epithelium%2C+nerve+and+bulb.&rft.au=Nakashima%2C+T%3BKimmelman%2C+C+P%3BSnow%2C+J+B&rft.aulast=Nakashima&rft.aufirst=T&rft.date=1985-04-01&rft.volume=95&rft.issue=4&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Immunohistopathologic analysis of olfactory degeneration caused by ischemia. AN - 85208167; pmid-3920624 AB - The development of olfactory dysfunction caused by ischemia was studied in Mongolian gerbils. Mongolian gerbils frequently have an anomaly of the cerebral circulation and are susceptible to brain ischemia or infarction following ligation of a single common carotid artery. Ischemia was induced by unilateral common carotid artery ligation or temporary occlusion of both common carotid arteries, and the olfactory pathway was examined. In the olfactory pathway of the forebrain, ischemic changes were observed in the lateral olfactory tract, olfactory tubercle, olfactory ventricle, and anterior olfactory nucleus. The olfactory bulb was resistant to ischemia. Partial or complete degeneration of the ipsilateral olfactory neuroepithelium was observed in some gerbils that survived more than 14 days after the onset of ischemia. Immunohistopathologic analysis of the neuroepithelium for the olfactory marker protein revealed that functional damage of the olfactory neurons occurred in some gerbils within the first few days after the ischemic event. JF - Otolaryngology--Head and Neck Surgery AU - Nakashima, T AU - Kimmelman, C P AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1985 SP - 40 EP - 47 VL - 93 IS - 1 SN - 0194-5998, 0194-5998 KW - Gerbillinae KW - Olfactory Pathways KW - Goats KW - Animal KW - Central Nervous System Diseases KW - Rabbits KW - Central Nervous System KW - Nerve Tissue Proteins KW - Carotid Arteries KW - Brain Ischemia KW - Ligation KW - Olfactory Bulb KW - Epithelium KW - Immunoenzyme Techniques KW - Olfactory Nerve UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85208167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Immunohistopathologic+analysis+of+olfactory+degeneration+caused+by+ischemia.&rft.au=Nakashima%2C+T%3BKimmelman%2C+C+P%3BSnow%2C+J+B&rft.aulast=Nakashima&rft.aufirst=T&rft.date=1985-02-01&rft.volume=93&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Current status of fluoride therapy for otosclerosis. AN - 85216928; pmid-3976859 JF - The American Journal of Otology AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1985 SP - 56 EP - 58 VL - 6 IS - 1 SN - 0192-9763, 0192-9763 KW - United States KW - Fluoridation KW - Human KW - Osteitis Deformans KW - Otosclerosis KW - Hearing Loss, Sensorineural KW - Sodium Fluoride UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85216928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Otology&rft.atitle=Current+status+of+fluoride+therapy+for+otosclerosis.&rft.au=Snow%2C+J+B&rft.aulast=Snow&rft.aufirst=J&rft.date=1985-01-01&rft.volume=6&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Otology&rft.issn=01929763&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Cytochrome P-450 monooxygenase, epoxide hydrolase and flavin monooxygenase activities in Clara cells and alveolar type II cells isolated from rabbit. AN - 76721911; 3917126 AB - The activities of several enzymes which metabolize xenobiotics were measured and compared in freshly isolated rabbit Clara cells (50-70% purity) and alveolar type II cells (80-95% purity) or microsomal preparations from the isolated cell fractions. The presence of 1 mM nicotinamide in protease and cell isolation buffers increased significantly 7-ethoxycoumarin (7-EC) deethylase and epoxide hydrolase activities in the isolated Clara and type II cells. Isolated Clara cell fractions metabolized 7-EC to umbelliferone at a rate of 241 +/- 27 pmoles/mg prot/min (mean +/- S.E., N =5), while the 7-EC deethylation rate in type II cells was 111 +/- 15 pmoles/mg prot/min. Coumarin hydroxylation activity, however, was more than ten times greater in the Clara cells than in the type II cells on a per mg cellular protein basis. N-oxidation of N,N-dimethylaniline, catalyzed by a flavin monooxygenase, was about 2 times as great in microsomes of Clara cells as in microsomes of type II cells. Epoxide hydrolase activity with benzo(a)pyrene 4,5-oxide as substrate was about 10 times higher in Clara cells than in type II cells. Because of the greater cellular, structural and functional heterogeneity in lung, differential distribution of enzymes responsible for xenobiotic metabolism in this tissue may contribute to cell selective chemical toxicity and carcinogenesis. JF - Cell biology and toxicology AU - Devereux, T R AU - Diliberto, J J AU - Fouts, J R AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. Y1 - 1985/01// PY - 1985 DA - January 1985 SP - 57 EP - 65 VL - 1 IS - 2 SN - 0742-2091, 0742-2091 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Oxygenases KW - EC 1.13.- KW - dimethylaniline monooxygenase (N-oxide forming) KW - EC 1.14.13.8 KW - Epoxide Hydrolases KW - EC 3.3.2.- KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Rabbits KW - Male KW - Epoxide Hydrolases -- metabolism KW - Oxygenases -- metabolism KW - Pulmonary Alveoli -- enzymology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Bronchi -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76721911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+biology+and+toxicology&rft.atitle=Cytochrome+P-450+monooxygenase%2C+epoxide+hydrolase+and+flavin+monooxygenase+activities+in+Clara+cells+and+alveolar+type+II+cells+isolated+from+rabbit.&rft.au=Devereux%2C+T+R%3BDiliberto%2C+J+J%3BFouts%2C+J+R&rft.aulast=Devereux&rft.aufirst=T&rft.date=1985-01-01&rft.volume=1&rft.issue=2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Cell+biology+and+toxicology&rft.issn=07422091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-20 N1 - Date created - 1990-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Patient-perceived side effects to antihypertensive drugs. AN - 76665896; 3870892 AB - The Hypertension Detection and Follow-up Program (HDFP) used two methods to collect data on drug side effects. First, questions were asked during annual home visits by nontherapist interviewers, and second, responses were elicited by questionnaire at each clinic visit. Frequency of side effects as reported by the participants was similar in stepped care and referred care participants. Among the stepped care participants attending clinic, 75 percent continued to report at least one of the side effects reported at baseline. New symptoms (not previously reported) were less frequent, reported by 14 percent. Although medications were discontinued in 17 percent of the HDFP participants due to side effects, less than 2 percent of those reporting side effects had their drug discontinued for the symptom they reported. We concluded that questionnaire-elicited reports of drug side effects are a relatively poor index of side effects. JF - American journal of preventive medicine AU - Curb, J D AU - Borhani, N O AU - Blaszkowski, T P AU - Zimbaldi, N AU - Fotiu, S AU - Williams, W AD - Hypertension Detection and Follow-up Program, National Heart, Lung, and Blood Institute, Bethesda, MD 20205. PY - 1985 SP - 36 EP - 40 VL - 1 IS - 1 SN - 0749-3797, 0749-3797 KW - Antihypertensive Agents KW - 0 KW - Index Medicus KW - Humans KW - Surveys and Questionnaires KW - Male KW - Female KW - Antihypertensive Agents -- adverse effects KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76665896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+preventive+medicine&rft.atitle=Patient-perceived+side+effects+to+antihypertensive+drugs.&rft.au=Curb%2C+J+D%3BBorhani%2C+N+O%3BBlaszkowski%2C+T+P%3BZimbaldi%2C+N%3BFotiu%2C+S%3BWilliams%2C+W&rft.aulast=Curb&rft.aufirst=J&rft.date=1985-01-01&rft.volume=1&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=American+journal+of+preventive+medicine&rft.issn=07493797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-29 N1 - Date created - 1988-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cyclosporine therapy for uveitis: long-term followup. AN - 76659749; 3880086 AB - Long term followup in 52 uveitis patients treated with Cyclosporine (CsA) is presented here. The patients included in this study all had intermediate or posterior uveitis of noninfectious etiology; and all were considered therapeutic failures to systemic corticosteroids and/or cytotoxic agents. Patients were considered a therapeutic success if the visual acuity in either eye improved two lines or more and/or the vitreal haze improved more than two grading levels. While five patients stopped therapy before the three month interval, 41 of 52 patients or 79% were therapeutic successes at three months after the initiation of CsA as the sole systemic immunosuppressive agent for their disease. Twenty-five of a potential 35 patients (71%) remained on CsA after one year's time, with 63% (22/35) of these individuals receiving the medication considered a therapeutic success. The patients who appeared to respond particularly well to CsA therapy were those with pars planitis, intermediate uveitis of the non-pars planitis type, VKH, and Behcet's disease. In vitro S-antigen (S-Ag) testing did not appear to have a predictive value in determining which patients would be therapeutic successes (improvement in visual acuity), however the S-Ag responder group did appear to have a statistically greater improvement in vitreal haze. Renal toxicity was by far the most common adverse effect, which we have found to be reversible with our approach to therapy. However, adverse reactions required a reduction in CsA dosage in some patients, making it not feasible to maintain therapeutically effective CsA levels. In those patients, low dose prednisone was added to these patients' CsA regimens with generally good results. We did not observe opportunistic infections nor CsA associated neoplasms in our patients. This long term study demonstrates the potential efficacy of CsA in the treatment of severe intra-ocular inflammatory disorders. However, we firmly believe that only in the context of a randomized clinical trial that a definitive evaluation as to the true effectiveness of CsA will be reached. JF - Journal of ocular pharmacology AU - Nussenblatt, R B AU - Palestine, A G AU - Chan, C C AD - Clinical Branch, National Eye Institute, Bethesda, Maryland. Y1 - 1985 PY - 1985 DA - 1985 SP - 369 EP - 382 VL - 1 IS - 4 SN - 8756-3320, 8756-3320 KW - Cyclosporins KW - 0 KW - Index Medicus KW - Humans KW - Visual Acuity -- drug effects KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Cyclosporins -- therapeutic use KW - Uveitis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76659749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+ocular+pharmacology&rft.atitle=Cyclosporine+therapy+for+uveitis%3A+long-term+followup.&rft.au=Nussenblatt%2C+R+B%3BPalestine%2C+A+G%3BChan%2C+C+C&rft.aulast=Nussenblatt&rft.aufirst=R&rft.date=1985-01-01&rft.volume=1&rft.issue=4&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Journal+of+ocular+pharmacology&rft.issn=87563320&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-17 N1 - Date created - 1989-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Inhibition of the Effects of Thyroid Hormone On Rat Liver By 5,5'-Diphenylthiohydantoin AN - 760215771; 13623371 AB - Metabolites were measured in freeze-clamped livers from rats that had been maintained for 3 weeks on a stock diet supplemented with 0.1 % 5,5'-diphenylthiohydantoin (DPTH). Compared with control animals, DPTH-treated animals had lower levels of phosphoenolypyruvate and 3-phosphoglycerate and elevated ratios of [ATP]/[ADP][P sub(i) ] and [NADP super(+)]/[NADPH], suggesting mild hypothyroidism. Conversely, the administration of thyroxine (T4) for 5 days to animals fed the control diet resulted in elevated levels of phosphoenolpyruvate, 3-phosphoglycerate, and ketone bodies and lowered ratios of[ATP]/[ADP][P sub(i)] and [NADP super(+)]/[NADPH], consistent with the known effects of thyroid hormones on liver tissues. In animals simultaneously treated with DPTH and T4, the effects of thyroxine on the [NADP super(+)]/[NADPH] ratio and the levels of phosphoenolypyruvate, 2-phosphoglycerate and ketone bodies were reversed. However, the calculated free cytoplasmic [ATP]/[ADP][P sub(i)] ratio and the calculated cytochrome c super(3+)/cytochrome C super(2+) ratio did not return to control values. This suggests that those actions of thyroid hormone which are mediated by potentiation of adrenergic effects are reversed by DPTH. These actions include a decrease in peripheral lipolysis, a reduction of the free cytoplasmic [NADP super(+)]/[NADPH] ratio, and an apparent inhibition of the pyruvate kinase reaction, but DPTH apparently does not reverse the effects of thyroid hormone on mitochondrial 02 consumption and A TP generation. JF - Toxicology and Industrial Health AU - Schaffer, Walter T AU - Veech, Richard AU - Mehlman, Myron A AU - Tobin, Richard B AD - Laboratory of Metabolism, NIAAA Rockville, MD 20852 Y1 - 1985 PY - 1985 DA - 1985 SP - 45 EP - 55 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 1 IS - 1 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts KW - Diets KW - Cytochromes KW - Potentiation KW - Mitochondria KW - ATP KW - Metabolites KW - NADP KW - Pyruvate kinase KW - Thyroid hormones KW - Ketone bodies KW - Liver KW - Thyroxine KW - Hypothyroidism KW - Lipolysis KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760215771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Inhibition+of+the+Effects+of+Thyroid+Hormone+On+Rat+Liver+By+5%2C5%27-Diphenylthiohydantoin&rft.au=Schaffer%2C+Walter+T%3BVeech%2C+Richard%3BMehlman%2C+Myron+A%3BTobin%2C+Richard+B&rft.aulast=Schaffer&rft.aufirst=Walter&rft.date=1985-01-01&rft.volume=1&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F074823378500100105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 36 N1 - Last updated - 2015-04-29 N1 - SubjectsTermNotLitGenreText - Diets; Cytochromes; Potentiation; ATP; Mitochondria; Metabolites; Pyruvate kinase; NADP; Thyroid hormones; Ketone bodies; Thyroxine; Liver; Hypothyroidism; Lipolysis DO - http://dx.doi.org/10.1177/074823378500100105 ER - TY - JOUR T1 - The ages of the Bayan Obo and Chaertai groups in central Nei Monggol discussed in the light of isotope geochronology AN - 51185294; 1986-072346 AB - The Bayan Obo and Chaertai groups are two important ore-bearing rock series, but their ages remain controversial for many years, and there is still an appreciable divergence of views as to the correlation between the two groups. In this study an attempt is made to apply isotope geochronology, which has proved to be an effective means for age determination of rocks and minerals, in providing a basis for solving the above-mentioned problems. The author and his colleagues have collected and processed the available isotopic age data of the middle Proterozoic Bayan Obo and Chaertai groups in Bayan Obo, Chaertai Mountain and Lang Mountain areas, and analysed and discussed the age data obtained by use of the Pb, U-Th-Pb, Rb-Sr and K-Ar methods. On that basis and in combination with various data regarding regional geology, stromatolites, paleomagnetism, lithofacies paleogeography and characteristics of mineral resources, the author puts forward his preliminary opinions on the ages of the Bayan Obo and Chaertai groups and their stratigraphic correlation. JF - Regional Geology of China = Zhongquo Quyu Dizhi AU - Ying, Dixian Y1 - 1985 PY - 1985 DA - 1985 SP - 125 EP - 135 PB - People's Republic of China, Ministry of Geology and Mineral Resources, Beijing VL - 1985 IS - 14 SN - 1000-3967, 1000-3967 KW - Far East KW - upper Precambrian KW - U/Pb KW - algae KW - Th/U KW - Rb/Sr KW - Bayon Obo Mountains KW - Lang Mountains KW - geochronology KW - dates KW - crystalline rocks KW - absolute age KW - Asia KW - sedimentary structures KW - China KW - Inner Mongolia China KW - Plantae KW - Precambrian KW - biogenic structures KW - Bayan Obo Group KW - Proterozoic KW - paleomagnetism KW - correlation KW - Chaertai Mountains KW - stromatolites KW - K/Ar KW - Chaertai Group KW - microfossils KW - 03:Geochronology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51185294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regional+Geology+of+China+%3D+Zhongquo+Quyu+Dizhi&rft.atitle=The+ages+of+the+Bayan+Obo+and+Chaertai+groups+in+central+Nei+Monggol+discussed+in+the+light+of+isotope+geochronology&rft.au=Ying%2C+Dixian&rft.aulast=Ying&rft.aufirst=Dixian&rft.date=1985-01-01&rft.volume=1985&rft.issue=14&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Regional+Geology+of+China+%3D+Zhongquo+Quyu+Dizhi&rft.issn=10003967&rft_id=info:doi/ LA - Chinese DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by National Geological Library, Beijing, China N1 - Date revised - 1986-01-01 N1 - Document feature - 12 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - absolute age; algae; Asia; Bayan Obo Group; Bayon Obo Mountains; biogenic structures; Chaertai Group; Chaertai Mountains; China; correlation; crystalline rocks; dates; Far East; geochronology; Inner Mongolia China; K/Ar; Lang Mountains; microfossils; paleomagnetism; Plantae; Precambrian; Proterozoic; Rb/Sr; sedimentary structures; stromatolites; Th/U; U/Pb; upper Precambrian ER - TY - JOUR T1 - Study on the Early Permian stratigraphy and fauna in Zhesi District, Nei Mongol Zizhiqu (Inner Mongolia) AN - 51108819; 1987-028970 JF - Zhongguo Dizhi Kexueyuan Tianjin Dizhi Kuangchan Yanjiusuo Suokan = Bulletin of the Tianjin Institute of Geology and Mineral Resources, Chinese Academy of Geological Sciences AU - Ding, Yunjie AU - Xia, Guoying AU - Duan, Chenghua AU - Li, Wenguo AU - Liu, Xiaoliang AU - Liang, Zhongfa Y1 - 1985 PY - 1985 DA - 1985 SP - 1 EP - 244 PB - Dizhi Chubanshe, Beijing VL - 10 SN - 1004-1931, 1004-1931 KW - Hugete Formation KW - Far East KW - Schwagerina bulegenesis KW - Lower Permian KW - paleontology KW - Monodiexodina yongwangcunensis KW - new taxa KW - Foraminifera KW - Pseudowaagenophyllum KW - Zoantharia KW - Brachiopoda KW - Anthozoa KW - Invertebrata KW - Zhesi District KW - Rhombospirifer KW - Codonofusielli simplicata KW - Articulata KW - Asia KW - China KW - stratigraphy KW - Inner Mongolia China KW - Fusulinidae KW - Yihewusu Formation KW - Rugosa KW - Protista KW - Damuqiphyllum KW - Paleozoic KW - Pseudostaffella zhesunsis KW - Coelenterata KW - Fusulinina KW - Permian KW - Zhesipora KW - Carinoverbeekiella KW - Lauserella yihewrisuensis KW - Zhesi Formation KW - Cnidaria KW - Mondulapora KW - microfossils KW - 10:Invertebrate paleontology KW - 12:Stratigraphy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51108819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zhongguo+Dizhi+Kexueyuan+Tianjin+Dizhi+Kuangchan+Yanjiusuo+Suokan+%3D+Bulletin+of+the+Tianjin+Institute+of+Geology+and+Mineral+Resources%2C+Chinese+Academy+of+Geological+Sciences&rft.atitle=Study+on+the+Early+Permian+stratigraphy+and+fauna+in+Zhesi+District%2C+Nei+Mongol+Zizhiqu+%28Inner+Mongolia%29&rft.au=Ding%2C+Yunjie%3BXia%2C+Guoying%3BDuan%2C+Chenghua%3BLi%2C+Wenguo%3BLiu%2C+Xiaoliang%3BLiang%2C+Zhongfa&rft.aulast=Ding&rft.aufirst=Yunjie&rft.date=1985-01-01&rft.volume=10&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Zhongguo+Dizhi+Kexueyuan+Tianjin+Dizhi+Kuangchan+Yanjiusuo+Suokan+%3D+Bulletin+of+the+Tianjin+Institute+of+Geology+and+Mineral+Resources%2C+Chinese+Academy+of+Geological+Sciences&rft.issn=10041931&rft_id=info:doi/ LA - Chinese DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1987-01-01 N1 - Number of references - 161 N1 - Document feature - illus. incl. 5 tables, 58 plates N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Anthozoa; Articulata; Asia; Brachiopoda; Carinoverbeekiella; China; Cnidaria; Codonofusielli simplicata; Coelenterata; Damuqiphyllum; Far East; Foraminifera; Fusulinidae; Fusulinina; Hugete Formation; Inner Mongolia China; Invertebrata; Lauserella yihewrisuensis; Lower Permian; microfossils; Mondulapora; Monodiexodina yongwangcunensis; new taxa; paleontology; Paleozoic; Permian; Protista; Pseudostaffella zhesunsis; Pseudowaagenophyllum; Rhombospirifer; Rugosa; Schwagerina bulegenesis; stratigraphy; Yihewusu Formation; Zhesi District; Zhesi Formation; Zhesipora; Zoantharia ER - TY - JOUR T1 - Comparative carcinogenesis by hydroxylated nitrosopropylamines in Syrian hamsters. AN - 14614235; 1485397 AB - The relationship between the chemical structure of nitrosamines and their carcinogenic activity has been examined in Syrian golden hamsters in parallel with similar studies in rats to aid in explaining the sharp interspecies differences in response to these compounds. The relationship between the beta -oxidized N-propylnitrosamine structure and the induction of tumors of the pancreatic duct in Syrian golden hamsters was investigated by administration of a number of asymmetric acyclic nitrosamines containing that structure to female hamsters for 29-50 weeks. N-Nitroso-2-oxopropyl-2-hydroxyethylamine (OPE), N-nitroso-2-hydroxypropyl-2-hydroxyethylamine (NIEA), and N-nitroso-2,3-dihydroxypropyl-2-oxopropylamine (DHPOP) induced pancreatic tumors. OPE also induced a high incidence of liver neoplasms, and a number of animals given NIEA and N-nitrosoallyl-2-oxopropylamine (NAOP) also had liver neoplasms. JF - Journal of the National Cancer Institute AU - Lijinsky, W AU - Knutsen, G L AU - Kovatch, R M AD - Basic Res. Program-Litton Bionetics, Inc., Chem. Carcinog. Program, NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 923 EP - 926 VL - 74 IS - 4 SN - 0027-8874, 0027-8874 KW - structure-activity relationships KW - derivatives KW - nitrosopropylamine KW - hamsters KW - Toxicology Abstracts KW - carcinogenicity KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14614235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Comparative+carcinogenesis+by+hydroxylated+nitrosopropylamines+in+Syrian+hamsters.&rft.au=Lijinsky%2C+W%3BKnutsen%2C+G+L%3BKovatch%2C+R+M&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1985-01-01&rft.volume=74&rft.issue=4&rft.spage=923&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity ER - TY - JOUR T1 - Primary structure and processing of gag and env gene products of human T-cell leukemia viruses HTLV-I sub(CR) and HTLV-I sub(ATK). AN - 14585053; 1464893 AB - Many of the immunological and biochemical properties of HTLV internal and envelope proteins are discussed in other chapters of this volume. Here the authors summarize the results of published and ongoing studies on the primary structure of human T-cell leukemia virus (HTLV) gag and env gene products. JF - Current Topics in Microbiology and Immunology AU - Oroszlan, S AU - Copeland, T D AD - Lab. Mol. Virol. and Carcinog., LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 221 EP - 234 VL - 115 SN - 0070-217X, 0070-217X KW - T cell leukemia virus I KW - amino acid sequence KW - env gene KW - gag gene KW - gene products KW - man KW - primary structure KW - reviews KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Virology & AIDS Abstracts KW - V 22050:Viral genetics including virus reactivation KW - G 07313:Viruses KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14585053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Topics+in+Microbiology+and+Immunology&rft.atitle=Primary+structure+and+processing+of+gag+and+env+gene+products+of+human+T-cell+leukemia+viruses+HTLV-I+sub%28CR%29+and+HTLV-I+sub%28ATK%29.&rft.au=Oroszlan%2C+S%3BCopeland%2C+T+D&rft.aulast=Oroszlan&rft.aufirst=S&rft.date=1985-01-01&rft.volume=115&rft.issue=&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Current+Topics+in+Microbiology+and+Immunology&rft.issn=0070217X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Issue on human T-cell leukemia lymphoma viruses. N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - primary structure; reviews; amino acid sequence; man; gene products ER - TY - JOUR T1 - Lack of evidence supporting a role for dopamine in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. AN - 14561380; 1442538 AB - Numerous investigators have suggested the ability of dopamine (DA) to oxidize to potentially cytotoxic quinones may be of pathological importance under certain conditions. To determine if DA may play a similar role in the neurotoxic effects of MPTP, male Swiss-Webster mice (30 g) were administered single injections of MPTP multiplied by HCl for 3 days. The results presented here do not support the suggestion that DA functions as a required intermediate in the generation of the neurotoxic response to MPTP. JF - European Journal of Pharmacology AU - Schmidt, C J AU - Bruckwick, E AU - Lovenberg, W AD - Natl. Inst. Health, NHLBI, Build. 10, Rm. 7N262, Bethesda, MD 20205, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 149 EP - 150 VL - 113 IS - 1 SN - 0014-2999, 0014-2999 KW - role KW - intermediary KW - dopamine KW - MPTP KW - rats KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - neurotoxicity KW - N3 11104:Mammals (except primates) KW - X 24117:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14561380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Pharmacology&rft.atitle=Lack+of+evidence+supporting+a+role+for+dopamine+in+1-methyl-4-phenyl-1%2C2%2C3%2C6-tetrahydropyridine+neurotoxicity.&rft.au=Schmidt%2C+C+J%3BBruckwick%2C+E%3BLovenberg%2C+W&rft.aulast=Schmidt&rft.aufirst=C&rft.date=1985-01-01&rft.volume=113&rft.issue=1&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - neurotoxicity ER - TY - JOUR T1 - An electron spin resonance investigation of the iron-catalyzed reaction of metronidazole with cysteine. AN - 14520880; 1413159 AB - Metronidazole is used in the treatment of protozoal and bacterial infections, and has been used as a radiation sensitizer in experimental research and clinical trials. This drug is rapidly decomposed by cysteine in the presence of ferric or ferrous iron. Electron spin resonance spectroscopy demonstrates the formation of two complexes composed of iron, cysteine, and NO. The nitric oxide is probably formed by the reduction of inorganic nitrite formed by the cleavage of the metronidazole nitro group from the imidazole ring. No such reaction occurred with the 2-nitroimidazole drug, misonidazole. JF - Journal of Inorganic Biochemistry AU - Mason, R P AU - Josephy, P D AD - Lab. Mol. Biophys., NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 161 EP - 165 VL - 24 IS - 2 SN - 0162-0134, 0162-0134 KW - E.S.R. KW - cysteine KW - interaction KW - metronidazole KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14520880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Inorganic+Biochemistry&rft.atitle=An+electron+spin+resonance+investigation+of+the+iron-catalyzed+reaction+of+metronidazole+with+cysteine.&rft.au=Mason%2C+R+P%3BJosephy%2C+P+D&rft.aulast=Mason&rft.aufirst=R&rft.date=1985-01-01&rft.volume=24&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Journal+of+Inorganic+Biochemistry&rft.issn=01620134&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Bovine leukemia virus post-envelope gene coded protein: Evidence for expression in natural infection. AN - 14497555; 1411922 AB - Partial sequence analysis of a 14 kilodalton protein (p14), synthesized by in vitro translation of bovine leukemia virus genomic RNA, showed that it is encoded in the "X" region of proviral DNA, located between the env gene and the 3' long terminal repeat. The "X" gene contains a short and a long open reading frame (X-SORF and X-LORF) which overlap. BLV p14 super(x) is specified by X-SORF. Antibodies in sera from animals with BLV induced tumors were shown to recognize p14 super(x). JF - Biochemical and Biophysical Research Communications AU - Yoshinaka, Y AU - Oroszlan, S AD - Lab. Mol. Virol. and Carcinog., LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21702, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 347 EP - 354 VL - 131 IS - 1 SN - 0006-291X, 0006-291X KW - DNA KW - amino acid sequence KW - bovine leukemia virus KW - coding KW - infectivity KW - mapping KW - proteins KW - proviruses KW - role KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - V 22050:Viral genetics including virus reactivation KW - G 07313:Viruses KW - N 14540:Structure, sequence & physical properties KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14497555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Bovine+leukemia+virus+post-envelope+gene+coded+protein%3A+Evidence+for+expression+in+natural+infection.&rft.au=Yoshinaka%2C+Y%3BOroszlan%2C+S&rft.aulast=Yoshinaka&rft.aufirst=Y&rft.date=1985-01-01&rft.volume=131&rft.issue=1&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - proviruses; amino acid sequence; DNA; proteins; coding ER - TY - JOUR T1 - Benzyl acetate carcinogenicity, metabolism, and disposition in Fischer 344 rats and B6C3F sub(1) mice. AN - 14397973; 1246711 AB - Carcinogenesis studies of benzyl acetate (a fragrance and flavoring agent) were conducted in F344 rats and B6C3F sub(1) mice. Benzyl acetate was absorbed from the gastrointestinal tract of rats and mice, with approximately 90% of the administered dose recovered as various metabolites in the urine within 24 h. The primary metabolite was hippuric acid, with minor amounts of a mercapturic acid, and one or more unidentified metabolites. Benzyl acetate administration was associated with an increased incidence of acinar cell adenoma of the exocrine pancreas in male F344/N rats. For male and female B6C3F sub(1) mice there was evidence of carcinogenicity, in that benzyl acetate caused an increased incidence of hepatocellular neoplasms (particularly adenomas) and squamous cell neoplasms of the forestomach. JF - Toxicology AU - Abdo, K M AU - Huff, JE AU - Haseman, J K AU - Boorman, G A AU - Eustis, S L AU - Matthews, H B AU - Burka, L T AU - Prejean, J D AU - Thompson, R B AD - Natl. Toxicol. Program, NIEHS, P.O. Box 12233, Research Triangle Park, NC, 27709, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 159 EP - 170 VL - 37 IS - 1-2 SN - 0300-483X, 0300-483X KW - benzyl acetate KW - rats KW - mice KW - Toxicology Abstracts KW - pancreas KW - carcinogenicity KW - metabolism KW - liver KW - stomach KW - X 24153:Metabolism KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14397973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Benzyl+acetate+carcinogenicity%2C+metabolism%2C+and+disposition+in+Fischer+344+rats+and+B6C3F+sub%281%29+mice.&rft.au=Abdo%2C+K+M%3BHuff%2C+JE%3BHaseman%2C+J+K%3BBoorman%2C+G+A%3BEustis%2C+S+L%3BMatthews%2C+H+B%3BBurka%2C+L+T%3BPrejean%2C+J+D%3BThompson%2C+R+B&rft.aulast=Abdo&rft.aufirst=K&rft.date=1985-01-01&rft.volume=37&rft.issue=1-2&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity; metabolism; pancreas; liver; stomach ER - TY - JOUR T1 - Cloning and expression of the EScherichia coli rho gene in a plasmid vector. AN - 14392703; 1259511 AB - In order to further elucidate the role of Rho protein on transcription termination and cells growth control, the authors have subcloned by two steps the rho super(+) structural gene of Escherichia coli) from Lambda rho super(+) sub(524) into a plasmid vector. The resulting plasmid pEG25 contains a 2.9 kbp insert which is able to complement several different rho mutations and to express a functional Rho protein in U.V. irradiated maxicells. JF - MICROBIOLOGICA (BOLOGNA). AU - Gulletta, E AU - Spagnuolo, G AU - Adhya, S AD - Dev. Gen. Sect., L.M.B., N.C.I., Natl. Inst. Health, Bethesda, MD, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 303 EP - 312 VL - 8 IS - 4 SN - 1121-7138, 1121-7138 KW - rho gene KW - plasmid pEG25 KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - cloning KW - genes KW - RNA biosynthesis KW - Escherichia coli KW - plasmids KW - termination KW - mutants KW - gene expression KW - G 07120:Recombinant DNA/Genetic engineering KW - N 14684:Expression of cloned genes KW - N 14674:Transformation KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14392703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MICROBIOLOGICA+%28BOLOGNA%29.&rft.atitle=Cloning+and+expression+of+the+EScherichia+coli+rho+gene+in+a+plasmid+vector.&rft.au=Gulletta%2C+E%3BSpagnuolo%2C+G%3BAdhya%2C+S&rft.aulast=Gulletta&rft.aufirst=E&rft.date=1985-01-01&rft.volume=8&rft.issue=4&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=MICROBIOLOGICA+%28BOLOGNA%29.&rft.issn=11217138&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; genes; RNA biosynthesis; termination; cloning; plasmids; gene expression; mutants ER - TY - JOUR T1 - Carcinogenesis by nonmutagenic chemicals: Early response of rat liver cells induced by methapyrilene. AN - 14384012; 1246371 AB - Although methapyrilene (MP) produces hepatocellular carcinomas in rats, it does not elicit many of the cellular responses induced by other hepatocarcinogens. We have investigated the early changes induced in rat liver epithelial cell cultures by MP using morphological, cytochemical, and cytofluorometric techniques. Within 2 h of MP treatment, inclusion bodies which were stainable with lipid stains were observed in the cytoplasm. Ultrastructurally, they resembled lamellar bodies with alternating light and dark lamellae. These bodies were transient in nature, since they disappeared within 24 h of removal of MP. They were, however, retained in the cytoplasm as long as MP was present in the medium. Lamellar bodies appear to be induced in the presence of histamine H1 receptor-blocking agents, since methaphenilene and diphenhydramine produced this reaction, but cimetidine, an H2 antagonist, did not. Collectively, these results suggest that MP might perturb the cytoskeletal elements leading to an alteration in the nuclear and mitochondrial makeup of rat liver cells. JF - Cancer Research AU - Iype, P T AU - Bucana, C D AU - Kelley, S P AD - LBI-Basic Res. Program, Chem. Carcinog. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 2184 EP - 2191 VL - 45 IS - 5 SN - 0008-5472, 0008-5472 KW - cells KW - effects on KW - cytochemistry KW - morphology KW - methapyrilene KW - rats KW - Toxicology Abstracts KW - antihistamines KW - carcinogenicity KW - liver KW - X 24115:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14384012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Carcinogenesis+by+nonmutagenic+chemicals%3A+Early+response+of+rat+liver+cells+induced+by+methapyrilene.&rft.au=Iype%2C+P+T%3BBucana%2C+C+D%3BKelley%2C+S+P&rft.aulast=Iype&rft.aufirst=P&rft.date=1985-01-01&rft.volume=45&rft.issue=5&rft.spage=2184&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity; antihistamines; liver ER - TY - JOUR T1 - Trans- and cis-acting elements for the replication of P1 miniplasmids. AN - 14362864; 1194106 AB - Replication-deficient mutants of the unit-copy miniplasmid lambda -P1:5R were isolated after hydroxylamine mutagenesis. Complementation tests showed that the majority of these mutants are defective in the production of the repA protein product. Two of these mutants have suppressible nonsense (amber) mutations. The DNA sequence of one of these, repA103, has been determined. The lesion lies within the repA open reading frame, showing that the repA product is essential for plasmid replication. Complementation of deletion mutants of lambda -P1:5R by repA protein showed that the origin of replication lies to the left of repA and that this 300-base-pair origin region is the only portion of the DNA essential for plasmid replication if repA protein is supplied in trans. Six of the 21 hydroxylamine-induced mutants were not complemented by repA. Replication of three of these could be restored by introduction into the plasmid of a wildtype origin region, suggesting that they were origin-defective. The DNA sequence of two mutants was determined. JF - Journal of Molecular Biology AU - Austin, S J AU - Mural, R J AU - Chattoraj, D K AU - Abeles, AL AD - Lab. Genet. and Recombinant DNA, NCI-Frederick Cancer Res. Program, LBI-Basic Res. Program, P.O. Box B, Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 195 EP - 202 VL - 183 IS - 2 SN - 0022-2836, 0022-2836 KW - plasmid lambda -P1:5R KW - phage PI KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - DNA biosynthesis KW - mutants KW - nucleotide sequence KW - plasmids KW - N 14651:Virus & phage infections KW - J 02760:Plasmids KW - G 07200:P PLASMIDS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14362864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Trans-+and+cis-acting+elements+for+the+replication+of+P1+miniplasmids.&rft.au=Austin%2C+S+J%3BMural%2C+R+J%3BChattoraj%2C+D+K%3BAbeles%2C+AL&rft.aulast=Austin&rft.aufirst=S&rft.date=1985-01-01&rft.volume=183&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - plasmids; mutants; nucleotide sequence; DNA biosynthesis ER - TY - JOUR T1 - Stimulation of intestinal adenylate cyclase by cholera toxin in malnourished rats. AN - 14303850; 1135590 AB - The stimulation of intestinal adenylate cyclase by cholera toxin (CT) was studied in normal and malnourished rats 4 to 24 hr after a 30-min incubation of intestinal loops with the toxin. Whereas in control rats the enzyme activity returned to basal levels after 12 hr of incubation, in malnourished rats the activity of the enzyme remained significantly elevated even after 24 hr of the initial incubation. Malnourished animals had a reduced turnover rate of intestinal cells as determined by thymidine kinase activity. The delayed turnover of intoxicated cells may account for continuous activation of mucosal adenylate cyclase and possibly for prolongation of diarrhea in malnutrition. JF - Proceedings of the Society for Experimental Biology and Medicine AU - Perez-Schael, I AU - Flores, J AD - Lab. Infect. Dis., NIAID, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 231 EP - 235 VL - 180 IS - 2 SN - 0037-9727, 0037-9727 KW - effects on KW - adenylate cyclase KW - rats KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Vibrio cholerae KW - toxins KW - intestine KW - X 24171:Microbial KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14303850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Society+for+Experimental+Biology+and+Medicine&rft.atitle=Stimulation+of+intestinal+adenylate+cyclase+by+cholera+toxin+in+malnourished+rats.&rft.au=Perez-Schael%2C+I%3BFlores%2C+J&rft.aulast=Perez-Schael&rft.aufirst=I&rft.date=1985-01-01&rft.volume=180&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Society+for+Experimental+Biology+and+Medicine&rft.issn=00379727&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Vibrio cholerae; toxins; intestine ER - TY - JOUR T1 - Interactions between food antigens and the immune system in the pathogenesis of gastrointestinal diseases. AN - 14300949; 1135204 AB - This review details the evidence that interactions between food antigens and the immune system may play a role in the pathogenesis of several gastrointestinal diseases. In immediate hypersensitivity reactions to foods involving the gastrointestinal system, in milk-induced gastrointestinal disease in infants and children, and in some forms of hypereosinophilic gastroenteritis, the evidence for the participation of food antigens is extensive. Gluten-induced enteropathy and some forms of dermatitis herpetiformis are also induced by defined food proteins where the response is specific and characteristic. The role of food antigens in the pathogenesis of inflammatory bowel disease is unclear, and warrants further studies. JF - ANN. ALLERGY. AU - Saavedra-Delgado, A M AU - Metcalfe, D D AD - Lab. Clin. Invest., NIAID-NIH, Build. 10, Rm. 11C210, Bethesda, MD 20205, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 694 EP - 705 VL - 55 IS - 5 SN - 0003-4738, 0003-4738 KW - effects on KW - Immunology Abstracts; Toxicology Abstracts KW - immune system KW - food hypersensitivity KW - man KW - antigens KW - X 24120:Food, additives & contaminants KW - F 06849:Delayed type UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14300949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ANN.+ALLERGY.&rft.atitle=Interactions+between+food+antigens+and+the+immune+system+in+the+pathogenesis+of+gastrointestinal+diseases.&rft.au=Saavedra-Delgado%2C+A+M%3BMetcalfe%2C+D+D&rft.aulast=Saavedra-Delgado&rft.aufirst=A&rft.date=1985-01-01&rft.volume=55&rft.issue=5&rft.spage=694&rft.isbn=&rft.btitle=&rft.title=ANN.+ALLERGY.&rft.issn=00034738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - food hypersensitivity; antigens; immune system; man ER - TY - JOUR T1 - Subchronic toxicity of vomitoxin in Sprague-Dawley rats. AN - 14289353; 1123132 AB - Purified vomitoxin was incorporated into the diet at a level of 20 ppm and fed to male Sprague-Dawley rats ad lib. for 90 days. Few clinical signs of toxicity were observed. Rats in the vomitoxin treatment group were less efficient in converting feed into body mass, but there was no feed refusal. Terminal body weight was reduced in the vomitoxin treatment group. There were no statistically significant effects on serum enzyme levels, haematological parameters or tissue lesions, or on liver detoxification systems, as reflected in levels of microsomal cyctochrome P-450 or in glutathione S-transferase activity. JF - Food and Chemical Toxicology AU - Morrissey, R E AU - Norred, W P AU - Vesonder, R F AD - NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 995 EP - 999 VL - 23 IS - 11 SN - 0278-6915, 0278-6915 KW - toxicity KW - vomitoxin KW - rats KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts KW - K 03082:Mycotoxins KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14289353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Subchronic+toxicity+of+vomitoxin+in+Sprague-Dawley+rats.&rft.au=Morrissey%2C+R+E%3BNorred%2C+W+P%3BVesonder%2C+R+F&rft.aulast=Morrissey&rft.aufirst=R&rft.date=1985-01-01&rft.volume=23&rft.issue=11&rft.spage=995&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Pertussis toxin inhibition of chemotaxis and the ADP-ribosylation of a membrane protein in a human-mouse hybrid cell line. AN - 14287784; 1108694 AB - When WBC264-9C cells are preincubated with pertussis toxin, chemotaxis is inhibited and ADP-ribosylation of a membrane protein with a subunit M sub(r) 41,000 is observed. Both the inhibition of chemotaxis and the ADP-ribosylation by pertussis toxin display a similar time lag, temperature dependence, and pertussis toxin-concentration dependence. Although the inhibition of chemotaxis and the ADP-ribosylation of the membrane protein are qualitatively correlated, nearly complete inhibition of chemotaxis occurs when there is only partial ADP-ribosylation of the membrane protein. The results suggest that a guanine nucleotide binding protein may be involved in chemotaxis, but they do not indicate an involvement of adenylate cyclase. JF - Proceedings of the National Academy of Sciences, USA AU - Backlund, PS Jr AU - Meade, B D AU - Manclark, C R AU - Cantoni, G L AU - Aksamit, R R AD - NIMH, Build. 36, Rm. 3006, 9000 Rockville Pike, Bethesda, MD 20205, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 2637 EP - 2641 VL - 82 IS - 9 SN - 0027-8424, 0027-8424 KW - inhibition KW - cell hybrids KW - mice KW - Bordetella pertussis KW - chemotaxis KW - man KW - toxins KW - Chemoreception Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 1: Biological Membranes (till 1993); Toxicology Abstracts KW - R 18042:Others KW - X 24171:Microbial KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14287784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Pertussis+toxin+inhibition+of+chemotaxis+and+the+ADP-ribosylation+of+a+membrane+protein+in+a+human-mouse+hybrid+cell+line.&rft.au=Backlund%2C+PS+Jr%3BMeade%2C+B+D%3BManclark%2C+C+R%3BCantoni%2C+G+L%3BAksamit%2C+R+R&rft.aulast=Backlund&rft.aufirst=PS&rft.date=1985-01-01&rft.volume=82&rft.issue=9&rft.spage=2637&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Bordetella pertussis; toxins; chemotaxis; man ER - TY - JOUR T1 - Responding to the needs of the homeless mentally ill. AN - 14281085; 1110761 AB - Homelessness and mental illness are social and clinical problems, respectively, distinct in some ways but intertwined in others. Some of the factors that contribute to homelessness-such as economic deprivations, a dearth of low-cost housing, discontinuities in social service systems, and radical changes in the composition of American families-are felt particularly keenly by many persons who are mentally ill. Developing appropriate and effective responses to the needs of homeless people who are mentally ill requires precise definition and identification of the target population, innovations in the mental health service system. JF - Public Health Reports AU - Frazier, SH AD - NIMH, Parklawn Build., 5600 Fishers Lane, Rm. 17-99, Rockville, MD 20857, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 462 EP - 469 VL - 100 IS - 5 SN - 0033-3549, 0033-3549 KW - mental health KW - United States KW - research and development KW - Health & Safety Science Abstracts KW - health care KW - economics KW - government programs KW - public health KW - H SM3.1:BASIC APPROACHES, CONCEPTS, AND THEORY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14281085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=Responding+to+the+needs+of+the+homeless+mentally+ill.&rft.au=Frazier%2C+SH&rft.aulast=Frazier&rft.aufirst=SH&rft.date=1985-01-01&rft.volume=100&rft.issue=5&rft.spage=462&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - public health; government programs; economics; health care ER - TY - JOUR T1 - Carcinogenesis by oxygenated nitrosomethylpropylamines in Syrian hamsters. AN - 14276944; 1117496 AB - Three oxygenated propylnitrosomethylamines were administered to female Syrian hamsters at doses similar to those which had induced high incidences of esophageal neoplasms in rats. Nitrosomethyl-2-oxopropylamine (NMOP) given at the rate of 2 mg/animal/week, whether as one application of 2 mg or two applications of 1 mg, led to early death of the animals, mostly with liver neoplasms. Only one hamster treated with NMOP had a neoplasm of the pancreatic duct. Of the 14 hamsters treated with the higher dose of nitrosomethyl-2-hydroxypropylamine (NMHP) and surviving beyond 6 weeks, most had liver neoplasms and nine had neoplasms of the pancreatic ducts. At the lower dose of NMHP, most hamsters developed neoplasms of the nasal mucosa, as did those receiving the same dose of NMOP, and seven animals had hemangioendothelial tumors of the liver, but only one animal had a carcinoma of the pancreatic duct. JF - Journal of Cancer Research and Clinical Oncology AU - Lijinsky, W AU - Kovatch, R M AU - Knutsen, G L AD - LBI-Basic Res. Program, Chem. Carcinogen. Program, NCI-Frederick Cancer Res. Facil. Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 1 EP - 4 VL - 109 IS - 1 SN - 0171-5216, 0171-5216 KW - nitrosomethylpropylamine KW - hamsters KW - Toxicology Abstracts KW - carcinogenesis KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14276944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cancer+Research+and+Clinical+Oncology&rft.atitle=Carcinogenesis+by+oxygenated+nitrosomethylpropylamines+in+Syrian+hamsters.&rft.au=Lijinsky%2C+W%3BKovatch%2C+R+M%3BKnutsen%2C+G+L&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1985-01-01&rft.volume=109&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cancer+Research+and+Clinical+Oncology&rft.issn=01715216&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenesis ER - TY - JOUR T1 - Acid lability of the hydrocarbon-deoxyribonucleoside linkages in 7,12-dimethylbenz(a)anthracene-modified deoxyribonucleic acid. AN - 14257183; 1085812 AB - DNA containing bound radioactive 7,12-dimethylbenz(a)anthracene was isolated from mouse fetal cell cultures exposed to this carcinogen. The carcinogen-deoxyriboside adducts within the DNA were found to be sensitive to acid-catalyzed hydrolysis. Adducts derived from reaction of a syn-dihydrodiol epoxide with deoxyadenosine residues in DNA were the most sensitive to acid and were hydrolyzed to yield a 1,2,3,4-tetrahydrotetraol of 7,12-dimethylbenz(a)anthracene under mild conditions. Although definitive structures cannot be assigned at present to the nucleic acid adducts of this potent carcinogen, the present findings confirm and extend earlier work assigning partial structures to the major adducts. JF - Biochemistry (Washington) AU - Dipple, A AU - Moschel, R C AU - Pigott, MA AU - Tondeur, Y AD - LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 2291 EP - 2298 VL - 24 IS - 9 SN - 0006-2960, 0006-2960 KW - adducts KW - structure KW - 9,10-dimethyl-1,2-benzanthracene KW - mice KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - carcinogens KW - DNA KW - N 14630:Chemical reactions & interactions, including effects of radiation KW - X 24190:Polycyclic hydrocarbons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14257183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Acid+lability+of+the+hydrocarbon-deoxyribonucleoside+linkages+in+7%2C12-dimethylbenz%28a%29anthracene-modified+deoxyribonucleic+acid.&rft.au=Dipple%2C+A%3BMoschel%2C+R+C%3BPigott%2C+MA%3BTondeur%2C+Y&rft.aulast=Dipple&rft.aufirst=A&rft.date=1985-01-01&rft.volume=24&rft.issue=9&rft.spage=2291&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogens; DNA ER - TY - JOUR T1 - Lack of genetic and in vitro metabolic activity of potently carcinogenic azoxyalkanes. AN - 14248251; 1066010 AB - 4 carcinogenic azoxyalkanes (azoxymethane, azoxyethane and the 2 mixed methyl-ethyl compounds) were examined for activity in the Salmonella histidine reversion assay and in a lambda -lacZ prophage induction assay. Because azoxyalkanes are isomeric with nitrosodialkylamines, and might be expected to generate the same active intermediates, their biological activity was investigated under conditions which would allow direct comparison with these well-studied carcinogens. However, none of the azoxyalkanes, which are liver carcinogens, showed significant activity in either microbial assay in the presence of liver S9. In addition, metabolism studies with liver microsomes or hepatocytes indicated that the compounds were metabolized only to a small extent, if at all, under the conditions examined. The results suggest that the carcinogenic action of azoxyalkanes proceeds through alternative metabolic pathways that are not adequately modeled by the assays and in vitro conditions used here. JF - Mutation Research AU - Lijinsky, W AU - Andrews, A W AU - Elespuru, R K AU - Farrelly, J G AD - LBI-Basic Res. Program, Chem. Carcinog. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 23 EP - 27 VL - 157 IS - 1 SN - 0027-5107, 0027-5107 KW - matabolism KW - in vitro KW - induction KW - reversion KW - assays KW - azoxyalkanes KW - histidine KW - Genetics Abstracts; Toxicology Abstracts KW - genotoxicity KW - prophages KW - Salmonella KW - X 24200:Nitrosamines & related compounds KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14248251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Lack+of+genetic+and+in+vitro+metabolic+activity+of+potently+carcinogenic+azoxyalkanes.&rft.au=Lijinsky%2C+W%3BAndrews%2C+A+W%3BElespuru%2C+R+K%3BFarrelly%2C+J+G&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1985-01-01&rft.volume=157&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Salmonella; genotoxicity; prophages ER - TY - JOUR T1 - The stability of mutagenic chemicals stored in solution. AN - 14243403; 1068441 AB - Using the Salmonella /microsome assay, the authors evaluated the stability of mutagenic responses of chemicals stored frozen over a period of 18 months. Sodium azide (NaN sub(3)) was dissolved in water; 4-nitro-o-phenylenediamine (4NOP), 4-nitroquinoline-N-oxide (4NQO), benzo(a)pyrene (B(a)P), and 2-aminoanthracene (2AA) were dissolved in DMSO. 4NOP, 4NQO, B(a)P, and 2AA showed no significant differences between the freshly prepared solutions and the solutions stored at -20 degree C and -80 degree C. NaN sub(3) did show a statistically significant difference, with the fresh samples giving the lowest mean responses and the -80 degree C treatment giving the highest. The freezing of mutagen solutions is adaptable to routine use and provides the advantage of reducing the time required to prepare positive control chemicals and reducing the exposure of laboratory personnel to known mutagens. JF - ENVIRON. MUTAG. AU - Pagano, DA AU - Zeiger, E AD - NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 293 EP - 302 VL - 7 IS - 3 KW - effects on KW - freezing KW - mutagenicity testing KW - preservation KW - Health & Safety Science Abstracts; Genetics Abstracts; Toxicology Abstracts KW - mutagens KW - Ames test KW - chemicals KW - H SM5.8.2:CHEMICALS (CORROSION) KW - G 07220:General theory/testing systems KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14243403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ENVIRON.+MUTAG.&rft.atitle=The+stability+of+mutagenic+chemicals+stored+in+solution.&rft.au=Pagano%2C+DA%3BZeiger%2C+E&rft.aulast=Pagano&rft.aufirst=DA&rft.date=1985-01-01&rft.volume=7&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=ENVIRON.+MUTAG.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - mutagens; Ames test; chemicals; freezing; mutagenicity testing; preservation ER - TY - JOUR T1 - A sequencers' sequence analysis package for the IBM PC. AN - 14237527; 1072594 AB - A set of programs providing tools for detailed primary analysis of nucleotide and amino acid sequences is presented. Several features not available with other packages are included. These features focus on means for presentation of data in a manner more desirable to the sequencer. Screen graphics have been used extensively to enhance several types of output. The programs are modular and are easily adapted for individual needs. Furthermore, any of these programs can be integrated with other packages to combine abilities. JF - GENE ANAL. TECH. AU - Stephens, R M AD - Lab. Mol. Virol., LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 67 EP - 75 VL - 2 IS - 4 KW - amino acid sequence KW - computer applications KW - computer programs KW - nucleotide sequence KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - N 14640:Structure & sequence KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14237527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=GENE+ANAL.+TECH.&rft.atitle=A+sequencers%27+sequence+analysis+package+for+the+IBM+PC.&rft.au=Stephens%2C+R+M&rft.aulast=Stephens&rft.aufirst=R&rft.date=1985-01-01&rft.volume=2&rft.issue=4&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=GENE+ANAL.+TECH.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - computer programs; nucleotide sequence; amino acid sequence; computer applications ER - TY - JOUR T1 - Immunosassay of DNA modified by ultraviolet radiation: A review. AN - 14226927; 1037774 AB - The development of immunological assays for the detection of modified and unmodified nuclei acid components began over 20 years ago with the demonstration that these compounds are antigenic under certain conditions. Since that time, a wide variety of antisera has been produced that are specific for DNA components modified by many different carcinogens, both chemical and physical. A recent article in this journal discussed some of the potential uses of antisera raised against DNA modified by chemical carcinogens. The present review will concentrate on studies from several laboratories using immunological assays to detect and quantitate alterations induced in DNA by ultraviolet (UV) radiation. The initial section summarizes the available information on antibody specificity since conclusions drawn from immunosassays depend critically on this information. The subsequent section discusses the use of immunoassays in several areas of photobiological research, including kinetics of DNA photoproduct repair in cultured cells and distribution and repair of photoproducts in skin. JF - ENVIRON. MUTAG. AU - Strickland, P T AD - Lab. Chem. and Phys. Carcinog., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 599 EP - 607 VL - 7 IS - 4 KW - effects on KW - damage KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - reviews KW - U.V. radiation KW - immunoassays KW - DNA KW - N 14100:Reviews KW - N 14653:Effect of antibiotics, antimetabolites & mutagens KW - X 24210:Radiation & radioactive materials KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14226927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ENVIRON.+MUTAG.&rft.atitle=Immunosassay+of+DNA+modified+by+ultraviolet+radiation%3A+A+review.&rft.au=Strickland%2C+P+T&rft.aulast=Strickland&rft.aufirst=P&rft.date=1985-01-01&rft.volume=7&rft.issue=4&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=ENVIRON.+MUTAG.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - DNA; immunoassays; U.V. radiation; reviews ER - TY - JOUR T1 - Drug abuse: Review of explanations and models of explanation. AN - 14204718; 1031696 AB - This paper reviews 43 explanations of drug dependence. Summaries of each cover their drug specificity, the population studied, the disciplinary background of the theorist and the key variables utilized. In addition to a discussion of the various theoretical explanations offered in the academic literature, a brief review of the models of explanation is presented including such models as classificatory, experimental, inductive, mathematical, and reference/authority. JF - ADV. ALCOHOL SUBSTANCE ABUSE. AU - Lettieri, D J AD - NIAAA, 5600 Fishers Lane, Room 14-C-20, Rockville, MD 20857, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 9 EP - 40 VL - 4 IS - 3-4 KW - drug abuse KW - Health & Safety Science Abstracts KW - adolescents KW - mathematical models KW - H SM10.40:DRUG ADDICTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14204718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ADV.+ALCOHOL+SUBSTANCE+ABUSE.&rft.atitle=Drug+abuse%3A+Review+of+explanations+and+models+of+explanation.&rft.au=Lettieri%2C+D+J&rft.aulast=Lettieri&rft.aufirst=D&rft.date=1985-01-01&rft.volume=4&rft.issue=3-4&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=ADV.+ALCOHOL+SUBSTANCE+ABUSE.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Special issue: Alcohol and Substance Abuse in Adolescence. N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - adolescents; mathematical models ER - TY - JOUR T1 - Moderate prenatal carbon monoxide exposure produces persistent, and apparently permanent, memory deficits in rats. AN - 14199063; 1023294 AB - The effects of moderate prenatal carbon monoxide (CO) exposure on learning and memory were assessed in young and aged adult rats using a two-way active avoidance paradigm. Collectively the data indicate that while young adult rats prenatally exposed to 150 ppm CO demonstrate an associative deficit restricted to memory impairment, aged adults similarly exposed during the prenatal period display a more pronounced deficit similar to that recently reported for animals tested as juveniles. The importance of parametric manipulations in uncovering long-term toxicity is also discussed. JF - Teratology AU - Mactutus, C F AU - Fechter, L D AD - Lab. Behav. and Neurol. Toxicol., NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 1 EP - 12 VL - 31 IS - 1 SN - 0040-3709, 0040-3709 KW - effects on KW - carbon monoxide KW - rats KW - intrauterine exposure KW - memory KW - Animal Behavior Abstracts; CSA Neurosciences Abstracts; Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - teratogenesis KW - H SM5.8.2:CHEMICALS (CORROSION) KW - X 24151:Acute exposure KW - N3 11104:Mammals (except primates) KW - Y 25637:Mammals (excluding primates) KW - P 6000:TOXICOLOGY AND HEALTH KW - Y 25817:Mammals (excluding primates) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14199063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratology&rft.atitle=Moderate+prenatal+carbon+monoxide+exposure+produces+persistent%2C+and+apparently+permanent%2C+memory+deficits+in+rats.&rft.au=Mactutus%2C+C+F%3BFechter%2C+L+D&rft.aulast=Mactutus&rft.aufirst=C&rft.date=1985-01-01&rft.volume=31&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carbon monoxide; rats; teratogenesis; intrauterine exposure; memory ER - TY - JOUR T1 - Possible interactions between warfarin and antineoplastic drugs. AN - 14187402; 995419 AB - The authors present three cases of possible interactions between warfarin and antineoplastic drugs and suggest that this drug toxicity is more common than previously reported. JF - CANCER TREAT. REP. AU - Seifter, E J AU - Brooks, BJ Jr AU - Urba, W J AD - Clin. Oncol. Program, NCI-Navy Med. Oncol. Branch, Build. 1, Rm. 415, Naval Hosp., Bethesda, MD 20814, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 244 EP - 246 VL - 69 IS - 2 SN - 0361-5960, 0361-5960 KW - time KW - warfarin KW - prothrombin KW - Toxicology Abstracts KW - side effects KW - antineoplastic drugs KW - man KW - drug interaction KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14187402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CANCER+TREAT.+REP.&rft.atitle=Possible+interactions+between+warfarin+and+antineoplastic+drugs.&rft.au=Seifter%2C+E+J%3BBrooks%2C+BJ+Jr%3BUrba%2C+W+J&rft.aulast=Seifter&rft.aufirst=E&rft.date=1985-01-01&rft.volume=69&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=CANCER+TREAT.+REP.&rft.issn=03615960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - antineoplastic drugs; drug interaction; side effects; man ER - TY - JOUR T1 - Immunocytochemical and morphological evidence for the origin of N-nitrosomethylurea-induced and naturally occurring primary lung tumors in F344/NCr rats. AN - 14186122; 995274 AB - Naturally occurring and N-nitrosomethylurea-induced lung tumors were studied in male F344/NCr rats by sequential histological, electron microscopic, and immunohistochemical methods. In rats receiving N-nitrosomethylurea, focal alveolar type II cell hyperplasia, adenoma in focal alveolar type II cell hyperplasia, and adenoma were found. The ultrastructure of these lesions supported immunocytochemical findings with evidence of lamellar bodies. This study provided morphological, immunohistochemical, and ultrastructural evidence that the vast majority of N-nitrosomethylurea-induced and naturally occurring pulmonary neoplasms of F344 rats are alveolar type II cell adenomas and carcinomas and that a portion of these tumors arise within focal alveolar type II cell hyperplasias. JF - Cancer Research AU - Ohshima, M AU - Ward, J M AU - Singh, G AU - Katyal, S L AD - NCI-Frederick Cancer Res. Facil., Build. 538, Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 2785 EP - 2792 VL - 45 IS - 6 SN - 0008-5472, 0008-5472 KW - ultrastructure KW - N-nitroso-N-methylurea KW - rats KW - Toxicology Abstracts KW - lung KW - tumorigenicity KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14186122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Immunocytochemical+and+morphological+evidence+for+the+origin+of+N-nitrosomethylurea-induced+and+naturally+occurring+primary+lung+tumors+in+F344%2FNCr+rats.&rft.au=Ohshima%2C+M%3BWard%2C+J+M%3BSingh%2C+G%3BKatyal%2C+S+L&rft.aulast=Ohshima&rft.aufirst=M&rft.date=1985-01-01&rft.volume=45&rft.issue=6&rft.spage=2785&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - tumorigenicity; lung ER - TY - JOUR T1 - Dose-related effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J and DBA/2J mice. AN - 14182424; 995426 AB - The dose-related effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were studied in B6D2F sub(1)/J (B6D), C57BL/6J (C57), and DBA/2J (DBA) mice. A 14-fold difference in lethality was observed in C57 and DBA mice. A progressive loss of body weight in all strains of mice was observed. Time-course studies in C57 mice treated with 200 mu g TCDD/kg body wt indicated that decreases in serum glucose and triglyceride concentrations and increases in hepatic triglyceride content occurred within 4 to 8 days of exposure. In concert, these observations demonstrate that decreased feed consumption (hypophagia) does not account for weight loss and changes in carbohydrate and lipid metabolism in TCDD-treated C57 mice. Dose-response experiments resulted in comparable changes in glucose and lipid parameters when DBA mice were exposed to 10-fold higher doses of TCDD than C57 mice. Parallel LD50 responses and parallel changes in carbohydrate and lipid metabolism, at 10- to 15-fold differences in dose range, are indicative of a common mechanism of toxicity in TCDD-treated C57 and DBA mice. JF - Toxicology and Applied Pharmacology AU - Chapman, DE AU - Schiller, C M AD - Lab. Pharmacol., NIEHS/NIH, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 147 EP - 157 VL - 78 IS - 1 SN - 0041-008X, 0041-008X KW - effects on KW - serum levels KW - TCDD KW - glucose KW - triglycerides KW - mice KW - Toxicology Abstracts KW - body weight KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14182424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Dose-related+effects+of+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin+%28TCDD%29+in+C57BL%2F6J+and+DBA%2F2J+mice.&rft.au=Chapman%2C+DE%3BSchiller%2C+C+M&rft.aulast=Chapman&rft.aufirst=DE&rft.date=1985-01-01&rft.volume=78&rft.issue=1&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - body weight ER - TY - JOUR T1 - Purification of human interleukin 1 from human monocyte culture supernatants and identity of thymocyte comitogenic factor, fibroblast-proliferation factor, acute-phase protein-inducing factor, and endogenous pyrogen. AN - 14156158; 965802 AB - Human interleukin 1 (IL-1) in lipopolysaccharide and silica-stimulated human peripheral blood monocyte culture supernatants was purified to apparent homogeneity by sequential chromatography using DEAE-Sephacel, Sephacryl S-200, CM-high-performance liquid chromatography (HPLC), and hydroxyapatite-HPLC. Analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) yielded only one band detectable by silver staining with an apparent molecular weight (MW) of 19,000 under nonreducing conditions. Amino acid composition analysis of the purified human IL-1 was similar to that previously described for murine IL-1. The purified IL-1 exhibited the biological previously attributed to IL-1, including thymocyte comitogenic activity, fibroblast proliferation activity, acute-phase protein (haptoglobin) inducing activity, and endogenous pyrogen activity. JF - Cellular Immunology AU - Matsushima, K AU - Durum, S K AU - Kimball, E S AU - Oppenheim, J J AD - Build. 560, Room 31-20, Lab. Mol. Immunoregul. BRMP, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 290 EP - 301 VL - 92 IS - 2 SN - 0008-8749, 0008-8749 KW - cell culture KW - characterization KW - interleukin 1 KW - man KW - monocytes KW - purification KW - supernatants KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - F 06774:Other cytokines (TNF, GM-CSF) KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14156158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Immunology&rft.atitle=Purification+of+human+interleukin+1+from+human+monocyte+culture+supernatants+and+identity+of+thymocyte+comitogenic+factor%2C+fibroblast-proliferation+factor%2C+acute-phase+protein-inducing+factor%2C+and+endogenous+pyrogen.&rft.au=Matsushima%2C+K%3BDurum%2C+S+K%3BKimball%2C+E+S%3BOppenheim%2C+J+J&rft.aulast=Matsushima&rft.aufirst=K&rft.date=1985-01-01&rft.volume=92&rft.issue=2&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Cellular+Immunology&rft.issn=00088749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - interleukin 1; monocytes; man ER - TY - JOUR T1 - Predisposition for cholera of individuals with O blood group. Possible evolutionary significance. AN - 14154557; 969562 AB - At the Matlab Hospital of the International Center for Diarrhoeal Disease Research, Bangladesh, the authors examined the blood groups of patients hospitalized between January and September 1979 for diarrheal disease due to a variety of bacterial and viral agents. A significant association was identified only for cholera, in which cholera patients were twice as likely to have blood group O and one-ninth as likely to have blood group AB as community controls. A follow-up study of family contacts of cholera patients, carried out between September 1980 and July 1982, indicated that blood group did not affect an individual's risk of having a culture-proven infection with V. cholerae 01 but was directly related to the severity of disease. The constant selective pressure of cholera against people of O blood group may account in part for the extremely low prevalence of O group genes and the high prevalence of B group genes found among the people living in the Gangetic Delta. JF - American Journal of Epidemiology AU - Glass, R I AU - Holmgren, J AU - Haley, CE AU - Khan, M R AU - Svennerholm, M AU - Stoll, B J AU - Belayet Hossain, KM AU - Black, R E AU - Yunus, M AU - Barua, D AD - Lab. Infect. Dis., NIAID, NIH, Build. 7, Rm. 100, Bethesda, MD 20205, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 791 EP - 796 VL - 121 IS - 6 SN - 0002-9262, 0002-9262 KW - susceptibility KW - association KW - Microbiology Abstracts B: Bacteriology KW - cholera KW - Vibrio cholerae KW - blood group O KW - man KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14154557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Predisposition+for+cholera+of+individuals+with+O+blood+group.+Possible+evolutionary+significance.&rft.au=Glass%2C+R+I%3BHolmgren%2C+J%3BHaley%2C+CE%3BKhan%2C+M+R%3BSvennerholm%2C+M%3BStoll%2C+B+J%3BBelayet+Hossain%2C+KM%3BBlack%2C+R+E%3BYunus%2C+M%3BBarua%2C+D&rft.aulast=Glass&rft.aufirst=R&rft.date=1985-01-01&rft.volume=121&rft.issue=6&rft.spage=791&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Vibrio cholerae; cholera; blood group O; man ER - TY - JOUR T1 - Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients. AN - 14144298; 964840 AB - The envelope (env ) and structural (gag ) gene products of human T-cell leukemia (lymphotropic) virus type III were identified by immunoaffinity chromatography, immunoprecipitation, and two-dimensional oligopeptide mapping methods. The env gene specifies a glycosylated polypeptide with a molecular weight of 160,000 (gp160) that is processed to gp120 and smaller gene products. The gag gene specifies two polypeptides of 70,000 and 55,000 molecular weight (p70 and p55), both of which contain p24, the major structural protein of the mature virion. The techniques in this study can be used to define the extent of variability of the env gene product among different virus isolates and may identify the nature and patterns of the humoral immune response that lead to an immunologically protected state. JF - Science (Washington) AU - Robey, W G AU - Safai, B AU - Oroszlan, S AU - Arthur, LO AU - Gonda, MA AU - Gallo, R C AU - Fischinger, P J AD - NCI-Frederick Cancer Res. Fac., Frederick, MD 21707, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 593 EP - 595 VL - 228 IS - 4699 SN - 0036-8075, 0036-8075 KW - T cell leukemia virus III KW - affinity chromatography KW - env gene KW - gag gene KW - gene products KW - immunoprecipitation KW - peptide mapping KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - V 22032:Viral proteins KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14144298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=Characterization+of+envelope+and+core+structural+gene+products+of+HTLV-III+with+sera+from+AIDS+patients.&rft.au=Robey%2C+W+G%3BSafai%2C+B%3BOroszlan%2C+S%3BArthur%2C+LO%3BGonda%2C+MA%3BGallo%2C+R+C%3BFischinger%2C+P+J&rft.aulast=Robey&rft.aufirst=W&rft.date=1985-01-01&rft.volume=228&rft.issue=4699&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - affinity chromatography; peptide mapping; gene products; immunoprecipitation ER - TY - JOUR T1 - Carcinogenic effect of nitrosoalkylureas and nitrosoalkylcarbamates in Syrian hamsters. AN - 14137177; 953757 AB - Three nitrosoalkylureas, two nitrosotrialkylureas, and three nitrosoalkylcarbamates were given to Syrian golden hamsters by gavage at approximately equimolar doses. Measured by the time to death with tumors as an index, nitrosoethylurea was the most potent carcinogen, followed by nitroso-2-hydroxyethylurea, which was less effective in males than in females. The least effective compounds, were nitrosooxzolidone and nitroso-5-methyloxazolidone. The remaining compounds, nitroso-N-ethylurethan, nitroso-2-hydroxypropylurea, nitrosomethyldiethylurea, and nitrosotriethylurea appeared to be of similar potency. All of the compounds induced papillomas or carcinomas of the nonglandular stomach in high incidence, except in the groups given nitrosohydroxyethylurea or nitrosooxazolidone. All of the nitrosoalkylureas induced a high incidence of hemangiosarcomas of the spleen. JF - Cancer Research AU - Lijinsky, W AU - Knutsen, G L AU - Kovatch, R M AD - LBI-Basic Res. Program, Chem. Carcinog. Program, NCI-Frederick Cancer Res. Fac., Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 542 EP - 545 VL - 45 IS - 2 SN - 0008-5472, 0008-5472 KW - comparison KW - cardinogenicity KW - nitrosoalkylureas KW - nitrosotrialkylureas KW - nitrosoalkylcarbamates KW - hamsters KW - Toxicology Abstracts KW - spleen KW - stomach KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14137177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Carcinogenic+effect+of+nitrosoalkylureas+and+nitrosoalkylcarbamates+in+Syrian+hamsters.&rft.au=Lijinsky%2C+W%3BKnutsen%2C+G+L%3BKovatch%2C+R+M&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1985-01-01&rft.volume=45&rft.issue=2&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - stomach; spleen ER - TY - JOUR T1 - Assay of mutagens in aqueous fecal extracts with a modified Ames Salmonella test. AN - 14116978; 943488 AB - Mutagenecity with Salmonella strain TA 100 can be determined by an island test in which only an isolated portion of a pour plate is spotted with a sample. The magnitude of the ratio of the numbers of revertant colonies on the treated and untreated parts of the plate reflects the potency of the mutagen. Five of six chemicals tested yielded statistically significant and generally linear dose-response curves. Minimum detectable mutagenic doses for four compounds calculated from the dose-response curves showed that the island test generally required less material for detection of mutagenicity than the liquid pre-incubation procedure. The island method was primarily designed to test the mutagenicity of aqueous extracts of human stool samples. Dose-responses were obtained for six such samples, and in two samples the amount of material needed for a positive response was significantly less than that required in the liquid pre-incubation method. JF - Teratogenesis, Carcinogenesis and Mutagenesis AU - Shaw, R AU - Andrews, A W AU - Riggs, C W AD - LBI-Basic Res. Program, Chem. Carcinog. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 15 EP - 28 VL - 5 IS - 1 SN - 0270-3211, 0270-3211 KW - samples KW - island test KW - Genetics Abstracts; Toxicology Abstracts KW - variation KW - mutagenicity testing KW - Ames test KW - man KW - feces KW - G 07220:General theory/testing systems KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14116978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+Carcinogenesis+and+Mutagenesis&rft.atitle=Assay+of+mutagens+in+aqueous+fecal+extracts+with+a+modified+Ames+Salmonella+test.&rft.au=Shaw%2C+R%3BAndrews%2C+A+W%3BRiggs%2C+C+W&rft.aulast=Shaw&rft.aufirst=R&rft.date=1985-01-01&rft.volume=5&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+Carcinogenesis+and+Mutagenesis&rft.issn=02703211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Ames test; mutagenicity testing; variation; man; feces ER - TY - JOUR T1 - Are the toxicities of pentobarbital and ethanol mediated by the GABA-benzodiazepine receptor-chloride ionophore complex?. AN - 14105053; 935173 AB - Both barbiturates and ethanol have been reported to interact with the GABA-benzodiazepine receptor-chloride ionophore "supramolecular complex". Some of the pharmacologic actions of barbiturates and ethanol may be mediated through this complex. In this study the authors administered a series of drugs which bind to various components of the complex in an attempt to antagonize the lethality of sodium pentobarbital, and ethanol-induced loss of righting reflex in mice. It was found that isopropylbicyclophosphate (IPPO), a cage convulsant which binds at or near the chloride ionophore, greatly reduces the overall mortality of animals pretreated with a lethal dose of pentobarbital. Picrotoxin also decreases pentobarbital lethality, but only at doses which were usually lethal when given alone. The observations suggest that the use of compounds which have a high affinity for the chloride ionophore in vitro might be fruitful in developing a clinical treatment for barbiturate or ethanol toxicity. JF - European Journal of Pharmacology AU - Mendelson, W B AU - Martin, J V AU - Wagner, R AU - Roseberry, C AU - Skolnick, P AU - Weissman, BA AU - Squires, R AD - Unit on Sleep Stud., CPB, NIMH, Build. 10-4S239, NIH, Bethesda, MD 20205, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 63 EP - 70 VL - 108 IS - 1 SN - 0014-2999, 0014-2999 KW - mediation KW - receptors KW - complex KW - pentobarbital sodium KW - alcohol KW - gamma -aminobutyric acid KW - benzodiazepines KW - mice KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - neurotoxicity KW - N3 11104:Mammals (except primates) KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14105053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Pharmacology&rft.atitle=Are+the+toxicities+of+pentobarbital+and+ethanol+mediated+by+the+GABA-benzodiazepine+receptor-chloride+ionophore+complex%3F.&rft.au=Mendelson%2C+W+B%3BMartin%2C+J+V%3BWagner%2C+R%3BRoseberry%2C+C%3BSkolnick%2C+P%3BWeissman%2C+BA%3BSquires%2C+R&rft.aulast=Mendelson&rft.aufirst=W&rft.date=1985-01-01&rft.volume=108&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - neurotoxicity ER - TY - JOUR T1 - Biosynthesis of fredericamycin A, a new antitumor antibiotic. AN - 14100792; 914701 AB - Fredericamycin A (FM A), produced by a strain of Streptomyces griseus , represents a new structural class of antitumor antibiotics containing a spiro ring system. Studies on the producer organism showed that glucose in the fermentation medium is not utilized until late in the growth stage, just prior to synthesis of FM A. ( super(14)C)Glucose tracer experiments demonstrated that glucose is incorporated into FM A by catabolism to acetate. Biosynthetic enrichment of FM A with single- and double-lableled ( super(13)C) acetate showed that the entire carbon skeleton of the spiro ring system is derived from acetate. A general model for FM A biosynthesis is proposed, and a possible scheme for the formation of the spiro carbon center is presented. JF - Biochemistry (Washington) AU - Byrne, K M AU - Hilton, B D AU - White, R J AU - Misra, R AU - Pandey, R C AD - Program Resour. Inc., NCI-Frederick Cancer Res. Facil., Ferment. Program, Frederick, MD 21701, USA Y1 - 1985 PY - 1985 DA - 1985 SP - 478 EP - 486 VL - 24 IS - 2 SN - 0006-2960, 0006-2960 KW - biosynthesis KW - new records KW - fredericamycin A KW - Streptomyces griseus KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - A 01013:Cytostatic & antitumor agents KW - J 02781:Biosynthesis and physicochemical properties KW - W 30410:Antibiotics and antitumor agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14100792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Biosynthesis+of+fredericamycin+A%2C+a+new+antitumor+antibiotic.&rft.au=Byrne%2C+K+M%3BHilton%2C+B+D%3BWhite%2C+R+J%3BMisra%2C+R%3BPandey%2C+R+C&rft.aulast=Byrne&rft.aufirst=K&rft.date=1985-01-01&rft.volume=24&rft.issue=2&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Streptomyces griseus ER - TY - JOUR T1 - Drinking water source and mortality in US cities AN - 13836035; 198503383 AB - A study of 473 large U.S.A. cities, where the populations exceeded 25,000 in 1950, established a link between cancer mortality and the use of surface water drinking supplies. Population data were taken from the census reports between 1950 and 1970, and figures for deaths from statistics for the period 1949 to 1971. Many other factors, including income, age, industrial activity and rainfall, were corrrelated, but it was concluded that drinking of surface water, rather than groundwater, resulted in a 2 per cent increase in all-cancer mortality. When other factors, such as misclassification of exposure due to population migration, the consideration of gastrointestinal and urinary tract cancers (rather than total cancers) and geographical variations, were taken into account, the increased risk associated with surface drinking waters appeared to be far greater than 2 per cent. The chlorination of surface waters and the resultant formation of halogenated hydrocarbons was suggested as a possible cause, but it could not be confirmed because 99 per cent of all surface waters were chlorinated. The results were compared with similar data from Canada and Great Britain, and a bibliography of 36 references is appended. JF - International Journal of Epidemiology AU - Morin, M M AU - Sharrett, A R AU - Bailey, K R AU - Fabsitz, R R AD - National Cancer Institute, Bethesda, Md. Y1 - 1985 PY - 1985 DA - 1985 SP - 254 EP - 264 VL - 14 IS - 2 SN - 0300-5771, 0300-5771 KW - Surface water (s/a lakes,ponds,reservoirs,streams) KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13836035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Epidemiology&rft.atitle=Drinking+water+source+and+mortality+in+US+cities&rft.au=Morin%2C+M+M%3BSharrett%2C+A+R%3BBailey%2C+K+R%3BFabsitz%2C+R+R&rft.aulast=Morin&rft.aufirst=M&rft.date=1985-01-01&rft.volume=14&rft.issue=2&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Theoretical. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Waste disposal technologies for polychlorinated biphenyls AN - 13830471; S198620054 AB - Methods for the disposal of polychlorinated biphenyls (PCB) are reviewed, with particular emphasis on burial and incineration. Topics considered include studies to simulate transport of PCB in saturated and unsaturated soils and the use of the simulation model to predict PCB movement in the soil; procedures for purification of contaminated aquifers; surface technology for rehabilitation and disposal of PCB wastes; chemical and microbiological methods for decomposition of PCB; thermal destruction of PCB; formation of polychlorinated dibenzofurans and polychlorinated dibenzodioxins during combustion of PCB; and design criteria for PCB incinerators. It is concluded that subsurface burial is unsatisfactory because of the non-degradability of PCB and the risk of long-term pollution of groundwater. Destruction by incineration can be very efficient, and the amount of residue left for final disposal is negligible if the incinerator is well designed and operated; the disadvantages of incineration are the cost and the risk of formation and emissions of highly toxic byproducts. A bibliography of 62 references is appended. JF - Environmental Health Perspectives AU - Piver, W T AU - Lindstrom, F T AD - NIEHS, Research Triangle Park, N.C. Y1 - 1985 PY - 1985 DA - 1985 SP - 163 EP - 177 VL - 59 SN - 0091-6765, 0091-6765 KW - Hazard KW - Modelling (-general-) KW - Pollution (s/a contamination, individ grps below) KW - Aqualine Abstracts KW - AQ 00007:Industrial Effluents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13830471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Waste+disposal+technologies+for+polychlorinated+biphenyls&rft.au=Piver%2C+W+T%3BLindstrom%2C+F+T&rft.aulast=Piver&rft.aufirst=W&rft.date=1985-01-01&rft.volume=59&rft.issue=&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Function and autoregulation of yeast copperthionein AN - 13827050; S198619206 AB - The endogenous copperthionein (CUP1) gene of yeast was replaced with the yeast URA3 gene in yeast strains, so that the physiological role of copperthionein in heavy metal detoxification, normal cell growth, and regulation could be tested. Although copperthionein protected cells against copper toxicity, it was not essential for normal haploid mitotic growth under laboratory conditions. Copperthionein was not required for copper accumulation, or activation of a specific copper enzyme in yeast grown on standard culture medium. Cells lacking the copperthionein gene were able to participate in all phases of the yeast life cycle. The transcription of CUP1 was negatively autoregulated, and it was suggested that autoregulation might play an important role in copper homeostasis in yeast. JF - Science AU - Hamer, D H AU - Thiele, D J AU - Lemontt, JE AD - National Institutes of Health, Bethesda, Md. Y1 - 1985 PY - 1985 DA - 1985 SP - 685 EP - 690 VL - 228 IS - 4700 KW - Enzymes (see also individual groups below) KW - Yeasts (see also individual groups below) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13827050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science&rft.atitle=Function+and+autoregulation+of+yeast+copperthionein&rft.au=Hamer%2C+D+H%3BThiele%2C+D+J%3BLemontt%2C+JE&rft.aulast=Hamer&rft.aufirst=D&rft.date=1985-01-01&rft.volume=228&rft.issue=4700&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Science&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Cowra water treatment plant uprating augmentation AN - 13824574; 198601008 AB - Improved facilities were added to the Cowra waterworks to increase plant capacity to meet increasing water demand. The separate flocculation tank was replaced by new flocculation compartments in the existing sedimentation tanks. Settling tube modules were also installed in these tanks. The existing sand filters were converted to mixed-media filters operating by declining-rate filtration. Other improvements included such items as new piping, chemical storage and handling facilities, and new control equipment. A flow diagram of the plant is included. JF - Water (Australia) AU - Jones, SMH AD - NEI John Thompson (Australia) Y1 - 1985 PY - 1985 DA - 1985 SP - 21 EP - 25 VL - 12 IS - 3 SN - 0310-0367, 0310-0367 KW - Equipment KW - Pipes (see also conduits, drains, pipelines,sewers) KW - Aqualine Abstracts KW - AQ 00004:Water Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13824574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+%28Australia%29&rft.atitle=Cowra+water+treatment+plant+uprating+augmentation&rft.au=Jones%2C+SMH&rft.aulast=Jones&rft.aufirst=SMH&rft.date=1985-01-01&rft.volume=12&rft.issue=3&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Water+%28Australia%29&rft.issn=03100367&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Guidelines for research involving recombinant DNA molecules. AN - 80924262; 11655642 JF - Federal register AU - U.S. National Institutes of Health AD - U.S. National Institutes of Health Y1 - 1984/11/23/ PY - 1984 DA - 1984 Nov 23 SP - 46266 EP - 46291 VL - 49 IS - 227 SN - 0097-6326, 0097-6326 KW - DNA, Recombinant KW - 0 KW - Hazardous Substances KW - Bioethics KW - Recombinant DNA Advisory Committee KW - Biomedical and Behavioral Research KW - Trade Secrets KW - National Institutes of Health KW - NIH Guidelines KW - Legal Approach KW - Research Personnel KW - Financial Support KW - Ecology KW - Humans KW - National Institutes of Health (U.S.) KW - Confidentiality KW - Public Policy KW - Ethics, Institutional KW - Advisory Committees KW - Government Regulation KW - Government KW - Social Control, Formal KW - Reference Standards KW - Guidelines as Topic KW - Federal Government KW - Containment of Biohazards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80924262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Guidelines+for+research+involving+recombinant+DNA+molecules.&rft.au=U.S.+National+Institutes+of+Health&rft.aulast=U.S.+National+Institutes+of+Health&rft.aufirst=&rft.date=1984-11-23&rft.volume=49&rft.issue=227&rft.spage=46266&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1985-03-13 N1 - Date created - 1985-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recombinant DNA research: actions under guidelines. AN - 80922688; 11655641 JF - Federal register AU - U.S. National Institutes of Health AD - U.S. National Institutes of Health Y1 - 1984/11/23/ PY - 1984 DA - 1984 Nov 23 SP - 46256 EP - 46263 VL - 49 IS - 227 SN - 0097-6326, 0097-6326 KW - DNA, Recombinant KW - 0 KW - Hazardous Substances KW - Bioethics KW - Recombinant DNA Advisory Committee KW - Biomedical and Behavioral Research KW - National Institutes of Health KW - NIH Guidelines KW - Legal Approach KW - Government Regulation KW - Government KW - Social Control, Formal KW - Reference Standards KW - National Institutes of Health (U.S.) KW - Guidelines as Topic KW - Federal Government KW - Containment of Biohazards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80922688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Recombinant+DNA+research%3A+actions+under+guidelines.&rft.au=U.S.+National+Institutes+of+Health&rft.aulast=U.S.+National+Institutes+of+Health&rft.aufirst=&rft.date=1984-11-23&rft.volume=49&rft.issue=227&rft.spage=46256&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1985-04-11 N1 - Date created - 1985-04-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Histiocytosis X of the temporal bone. AN - 85196183; pmid-6438592 JF - Otolaryngology--Head and Neck Surgery AU - Kimmelman, C P AU - Nielsen, E AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1984 SP - 588 EP - 590 VL - 92 IS - 5 SN - 0194-5998, 0194-5998 KW - Human KW - Aged KW - Case Report KW - Histiocytosis, Langerhans-Cell KW - Bone Diseases KW - Female KW - Temporal Bone UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85196183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Histiocytosis+X+of+the+temporal+bone.&rft.au=Kimmelman%2C+C+P%3BNielsen%2C+E%3BSnow%2C+J+B&rft.aulast=Kimmelman&rft.aufirst=C&rft.date=1984-10-01&rft.volume=92&rft.issue=5&rft.spage=588&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effects of aplysiatoxin and debromoaplysiatoxin on growth and differentiation of normal human bronchial epithelial cells. AN - 75970508; 6400920 AB - The effects of aplysiatoxin and debromoaplysiatoxin on the clonal growth rate, cross-linked envelope formation and plasminogen activator secretion of normal human bronchial epithelial cells were studied. Neither compound was mitogenic over a wide range of concentrations (10(-13) to 10(-7)M). Both aplysiatoxin and debromoaplysiatoxin inhibited clonal growth rate with 50% inhibitory concentrations of 3 x 10(-11)M and 10(-10)M, respectively. Both compounds induced the formation of cross-linked envelopes and increased plasminogen activator secretion with equal potency. These data are similar to those previously obtained with 12-O-tetradecanoylphorbol-13-acetate and teleocidin B and suggest that aplysiatoxin and debromoaplysiatoxin induce terminal squamous differentiation in normal human bronchial epithelial cells. JF - Cell biology and toxicology AU - Willey, J C AU - Moser, C E AU - Harris, C C AD - Division of Cancer Etiology, National Cancer Institute, Bethesda, MD 20205. Y1 - 1984/10// PY - 1984 DA - October 1984 SP - 145 EP - 154 VL - 1 IS - 1 SN - 0742-2091, 0742-2091 KW - Lyngbya Toxins KW - 0 KW - debromoaplysiatoxin KW - 52423-28-6 KW - aplysiatoxin KW - 52659-57-1 KW - Index Medicus KW - Cells, Cultured KW - Humans KW - Cell Division -- drug effects KW - Epithelium KW - Bronchi -- cytology KW - Bronchi -- drug effects KW - Lyngbya Toxins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75970508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+biology+and+toxicology&rft.atitle=Effects+of+aplysiatoxin+and+debromoaplysiatoxin+on+growth+and+differentiation+of+normal+human+bronchial+epithelial+cells.&rft.au=Willey%2C+J+C%3BMoser%2C+C+E%3BHarris%2C+C+C&rft.aulast=Willey&rft.aufirst=J&rft.date=1984-10-01&rft.volume=1&rft.issue=1&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Cell+biology+and+toxicology&rft.issn=07422091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-20 N1 - Date created - 1990-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recombinant DNA research; actions under guidelines; notice. AN - 80924167; 11655581 JF - Federal register AU - U.S. National Institutes of Health AD - U.S. National Institutes of Health Y1 - 1984/04/25/ PY - 1984 DA - 1984 Apr 25 SP - 17844 EP - 17848 VL - 49 IS - 81 SN - 0097-6326, 0097-6326 KW - DNA, Recombinant KW - 0 KW - Hazardous Substances KW - Bioethics KW - Rifkin KW - Recombinant DNA Advisory Committee KW - Biomedical and Behavioral Research KW - National Institutes of Health KW - NIH Guidelines KW - Legal Approach KW - National Institutes of Health (U.S.) KW - Human Experimentation KW - Public Policy KW - Advisory Committees KW - Ecology KW - Government Regulation KW - Government KW - Social Control, Formal KW - Federal Government KW - Containment of Biohazards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80924167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Recombinant+DNA+research%3B+actions+under+guidelines%3B+notice.&rft.au=U.S.+National+Institutes+of+Health&rft.aulast=U.S.+National+Institutes+of+Health&rft.aufirst=&rft.date=1984-04-25&rft.volume=49&rft.issue=81&rft.spage=17844&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1984-05-30 N1 - Date created - 1984-05-30 N1 - Date revised - 2017-01-13 N1 - People - Rifkin N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Rifkin ER - TY - JOUR T1 - Diagnosis and therapy for acute laryngeal and tracheal trauma. AN - 85201483; pmid-6718010 AB - A laryngeal fracture should be suspected when there is hemoptysis and subcutaneous emphysema following blunt injury to the neck. Computed tomography of the neck should be used to define the extent of the injury. Cervical vertebral fractures and dislocations, perforation of the pharynx and esophagus, and vascular injuries must be excluded. Establishment of a secure airway by tracheotomy, avoidance of flexion or extension of the neck until cervical vertebral injuries are excluded, and evaluation for recurrent laryngeal paralysis are of great importance. The repair of the fractured larynx requires prompt repair of lacerations of the mucous membrane, reduction of cartilaginous fractures, and internal splinting for six weeks. Anastomosis of the transected trachea is carried out prior to repair of the recurrent laryngeal nerve injury. Although suturing of the transected nerve is controversial, there is general agreement that implantation of the avulsed recurrent laryngeal nerve in the posterior cricoarytenoid muscle is appropriate. JF - Otolaryngologic Clinics of North America AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1984 SP - 101 EP - 106 VL - 17 IS - 1 SN - 0030-6665, 0030-6665 KW - Human KW - Laryngeal Cartilages KW - Larynx KW - Tomography, X-Ray Computed KW - Wounds, Nonpenetrating KW - Recurrent Laryngeal Nerve KW - Trachea UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85201483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngologic+Clinics+of+North+America&rft.atitle=Diagnosis+and+therapy+for+acute+laryngeal+and+tracheal+trauma.&rft.au=Snow%2C+J+B&rft.aulast=Snow&rft.aufirst=J&rft.date=1984-02-01&rft.volume=17&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Otolaryngologic+Clinics+of+North+America&rft.issn=00306665&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Surgical therapy for vocal dysfunction. AN - 85201040; pmid-6718029 AB - In general, misuse and abuse of the voice in the form of using the voice too loudly and too long and affecting a fundamental frequency that is too low produce chronic changes in the lamina propria while inhalation of irritants produces changes in the epithelium of the true vocal cords. Voice therapy plays an essential role in the preoperative and postoperative management of the patient. The use of the operative microscope under general anesthesia has permitted the regular preservation of the external elastic lamina, which is necessary for the restoration of the voice to its full dynamic and frequency ranges. Resection of the left recurrent laryngeal nerve is of great value in the treatment of spastic dysphonia. In the paralyzed larynx, injection of Teflon paste is of proven value in restoring the voice in permanent unilateral recurrent laryngeal nerve paralysis. Reinnervation procedures for unilateral and bilateral recurrent laryngeal nerve and superior laryngeal nerve paralysis must at this time be considered developmental. JF - Otolaryngologic Clinics of North America AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1984 SP - 91 EP - 100 VL - 17 IS - 1 SN - 0030-6665, 0030-6665 KW - Laryngeal Nerves KW - Vocal Cords KW - Speech Acoustics KW - Ulcer KW - Human KW - Vocal Cord Paralysis KW - Larynx KW - Polyps KW - Laryngeal Neoplasms KW - Child KW - Voice Disorders KW - Laryngeal Diseases KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85201040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngologic+Clinics+of+North+America&rft.atitle=Surgical+therapy+for+vocal+dysfunction.&rft.au=Snow%2C+J+B&rft.aulast=Snow&rft.aufirst=J&rft.date=1984-02-01&rft.volume=17&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Otolaryngologic+Clinics+of+North+America&rft.issn=00306665&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Histopathology of the olfactory pathway due to ischemia. AN - 85181354; pmid-6694485 AB - Various agents, such as trauma, viral infections and neoplasms cause olfactory dysfunction. However, little is understood concerning the role of ischemia. An experimental model of brain ischemia was developed in the Mongolian gerbil, and the olfactory pathway was studied. This animal was chosen because of its incomplete circle of Willis, since poor patency of the circle of Willis is not an uncommon finding in the aging human. Ischemia was induced by unilateral ligation of one common carotid artery or temporary occlusion of both common carotid arteries. Under both circumstances, ischemic changes occurred in the lateral olfactory tract, the olfactory ventricle, and the olfactory tubercle. Damage is more severe with bilateral temporary occlusion than unilateral ligation. The olfactory bulbs and neuroepithelium, however, are resistant to ischemia. JF - The Laryngoscope AU - Nakashima, T AU - Kimmelman, C P AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1984 SP - 171 EP - 175 VL - 94 IS - 2 Pt 1 SN - 0023-852X, 0023-852X KW - Cerebral Cortex KW - Frontal Lobe KW - Gerbillinae KW - Olfactory Pathways KW - Animal KW - Brain KW - Brain Ischemia KW - Olfactory Bulb KW - Central Nervous System KW - Olfactory Mucosa UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85181354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Histopathology+of+the+olfactory+pathway+due+to+ischemia.&rft.au=Nakashima%2C+T%3BKimmelman%2C+C+P%3BSnow%2C+J+B&rft.aulast=Nakashima&rft.aufirst=T&rft.date=1984-02-01&rft.volume=94&rft.issue=2+Pt+1&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Use of historical control data in carcinogenicity studies in rodents. AN - 80922452; 11478313 AB - This paper considers the use of historical control data in the evaluation of tumor incidences from carcinogenicity studies in rodents. Although the most appropriate control group for interpretative purposes is always the concurrent control, there are instances in which the use of historical control information can aid an investigator in the overall evaluation of tumor incidence data. One example is rare tumors; another is a tumor that shows a marginally significant result relative to concurrent controls. However, before historical control data can be used in a formal testing framework, a number of important issues must first be considered. The nomenclature conventions and diagnostic criteria for each study should be identical to insure unambiguous identification of all relevant tumors in the historical control database. Criteria should be established that will aid in determining whether a particular study should be included in the database. This will assure a homogeneous set of studies upon which to base statistical comparisons. Since study-to-study variability in tumor rates may exceed what would be expected by chance alone, these sources of variability should be identified and controlled. Finally, statistical procedures should be employed that adjust for extra-binomial variability. This paper also summarizes tumor incidence data from untreated Fischer 344 rats and B6C3F1 mice in the National Toxicology Program (NTP) historical control database. All studies in the database are of two years duration, and all neoplasms occurring with a frequency of 0.5% or more are reported. JF - Toxicologic pathology AU - Haseman, J K AU - Huff, J AU - Boorman, G A AD - Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 1984 PY - 1984 DA - 1984 SP - 126 EP - 135 VL - 12 IS - 2 SN - 0192-6233, 0192-6233 KW - Carcinogens KW - 0 KW - Index Medicus KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Reference Values KW - Rats, Inbred F344 KW - Mice KW - Male KW - Female KW - Toxicity Tests -- statistics & numerical data KW - Carcinogens -- toxicity KW - Toxicity Tests -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80922452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Use+of+historical+control+data+in+carcinogenicity+studies+in+rodents.&rft.au=Haseman%2C+J+K%3BHuff%2C+J%3BBoorman%2C+G+A&rft.aulast=Haseman&rft.aufirst=J&rft.date=1984-01-01&rft.volume=12&rft.issue=2&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-23 N1 - Date created - 2001-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of radiation induced transformation by combinations of a phorbol diester and a lymphotoxin. AN - 80922201; 11478318 AB - The susceptibility of normal Syrian hamster embryo cells to transformation by environmental carcinogens has made possible the determination of a variety of responses as cells proceed to the neoplastic state. Expression of the initiated and promoted stages of irradiation carcinogenesis, for example, can be modified by cell surface alterations. Phytohemagglutin (PHA) or its isolectins decrease 12-O-tetradecanolphorbal-13-acetate (TPA) promoted transformation whereas PHA does not affect carcinogen only induced transformation. In contrast, both initiated and promoted transformation are sensitive to hamster lymphotoxin, a hormone-like, non-antibody lymphocyte glycoprotein. A 48 hr lymphotoxin treatment before or immediately after X-irradiation, or during TPA exposure causes a persistent inhibition independent of when carcinogen was added. A 6 hr lymphotoxin pulse before irradiation and TPA causes a persistent but nonpermanent effect unless followed by the carcinogen treatment; lymphotoxin becomes more potent as the interval between the lymphotoxin pulse and carcinogen insult or TPA addition is reduced. PHA and lymphotoxin affect the biological activity of TPA by diverse mechanisms. PHA may alter either the binding of TPA to a critical cellular receptor for promotion or alter a later step in promotion. Lymphotoxin can prevent the initiation of transformation and modulate carcinogenesis as well at both initiated and promoted stages in the transition to the neoplastic state. JF - Toxicologic pathology AU - DiPaolo, J A AU - Doniger, J AU - Popescu, N C AU - Evans, C H AD - Laboratory of Biology, Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205, USA. Y1 - 1984 PY - 1984 DA - 1984 SP - 168 EP - 172 VL - 12 IS - 2 SN - 0192-6233, 0192-6233 KW - Lymphotoxin-alpha KW - 0 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Ultraviolet Rays KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Mesocricetus KW - Dose-Response Relationship, Radiation KW - Embryo, Mammalian KW - Cricetinae KW - Tetradecanoylphorbol Acetate -- toxicity KW - Cell Transformation, Neoplastic -- radiation effects KW - Lymphotoxin-alpha -- pharmacology KW - Neoplasms, Radiation-Induced -- prevention & control KW - Cell Transformation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80922201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Modulation+of+radiation+induced+transformation+by+combinations+of+a+phorbol+diester+and+a+lymphotoxin.&rft.au=DiPaolo%2C+J+A%3BDoniger%2C+J%3BPopescu%2C+N+C%3BEvans%2C+C+H&rft.aulast=DiPaolo&rft.aufirst=J&rft.date=1984-01-01&rft.volume=12&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-23 N1 - Date created - 2001-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phenotyping cytochromes P450 with monoclonal antibodies. AN - 80921442; 11478317 AB - Monoclonal antibodies (MAbs) to cytochrome P-450 isozymes can be used to phenotype tissues for epitope-specific cytochrome P-450 content. MAbs that inhibit specific cytochrome P-450 dependent drug or carcinogen reactions are useful tools for quantitative measurement of the individual or classes of cytochromes P-450 that catalyze these reactions. This method has been applied successfully to animal as well as human tissues. Radioimmunoassays based on MAbs have been developed and provide a rapid and efficient means for detecting cytochromes P-450 independent of functional enzyme activity. In addition, MAbs coupled to a Sepharose support can be used to immunopurify cytochromes P-450 in a procedure that is more rapid and efficient than conventional purification schemes. MAbs add a new dimension to analyses of cytochrome P-450 multiplicity and will find numerous applications in elucidation of the relationship between cytochrome P-450 phenotype and carcinogen or drug metabolism. JF - Toxicologic pathology AU - Friedman, F K AU - Park, S S AU - Fujino, T AU - Song, B J AU - Robinson, R C AU - West, D AU - Radkowsky, A K AU - Miller, H AU - Gelboin, H V AD - Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20205, USA. Y1 - 1984 PY - 1984 DA - 1984 SP - 155 EP - 161 VL - 12 IS - 2 SN - 0192-6233, 0192-6233 KW - Antibodies, Monoclonal KW - 0 KW - Isoenzymes KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Phenotype KW - Animals KW - Humans KW - Radioimmunoassay KW - Epitope Mapping KW - Cytochrome P-450 Enzyme System -- isolation & purification KW - Cytochrome P-450 Enzyme System -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80921442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Phenotyping+cytochromes+P450+with+monoclonal+antibodies.&rft.au=Friedman%2C+F+K%3BPark%2C+S+S%3BFujino%2C+T%3BSong%2C+B+J%3BRobinson%2C+R+C%3BWest%2C+D%3BRadkowsky%2C+A+K%3BMiller%2C+H%3BGelboin%2C+H+V&rft.aulast=Friedman&rft.aufirst=F&rft.date=1984-01-01&rft.volume=12&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-23 N1 - Date created - 2001-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Papovaviral sialoadenitis in athymic nude rats. AN - 80919991; 10628795 AB - A wasting disease was found in 32 athymic nude rats. The rats had parotid sialoadenitis with intranuclear inclusion bodies in ductal and acinar epithelial cells. Other common lesions included bronchitis, bronchiolitis and secondary bacterial pneumonia. Less commonly, rhinitis and Harderian adenitis were seen. Intranuclear inclusions were also seen in bronchial epithelium of 1 rat, Harderian gland acini of 1 rat and laryngeal glands of 2 rats. Viral particles, averaging 45 nm in diameter, sometimes in crystalline arrays, were found in the nucleus of parotid epithelial cells. By the use of the avidin-biotin-peroxidase complex (ABC) immunoperoxidase technique, antibodies to disrupted SV40 virus (the group specific antigen of the polyomavirus (miopapovavirus) genus of the papovavirus family) reacted with intranuclear inclusions and cytoplasm of parotid epithelium and inclusions in lung and Harderian gland. The viral antigen did not cross react with antibodies to mouse polyoma, mouse K or disrupted bovine papilloma viruses. JF - Laboratory animals AU - Ward, J M AU - Lock, A AU - Collins, M J AU - Gonda, M A AU - Reynolds, C W AD - Tumor Pathology and Pathogenesis Section, Laboratory of Comparative Carcinogenesis, Division of Cancer Cause and Prevention, National Cancer Institute, Frederick, Maryland 21701, USA. Y1 - 1984/01// PY - 1984 DA - January 1984 SP - 84 EP - 89 VL - 18 IS - 1 SN - 0023-6772, 0023-6772 KW - Index Medicus KW - Rats KW - Animals KW - Inclusion Bodies, Viral -- ultrastructure KW - Inclusion Bodies, Viral -- virology KW - Parotid Gland -- virology KW - Male KW - Female KW - Sialadenitis -- veterinary KW - Polyomavirus Infections -- pathology KW - Sialadenitis -- virology KW - Polyomavirus -- classification KW - Polyomavirus Infections -- virology KW - Rodent Diseases -- virology KW - Rodent Diseases -- pathology KW - Sialadenitis -- pathology KW - Virion -- ultrastructure KW - Virion -- classification KW - Rats, Nude KW - Virion -- isolation & purification KW - Polyomavirus -- isolation & purification KW - Polyomavirus Infections -- veterinary KW - Polyomavirus -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80919991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+animals&rft.atitle=Papovaviral+sialoadenitis+in+athymic+nude+rats.&rft.au=Ward%2C+J+M%3BLock%2C+A%3BCollins%2C+M+J%3BGonda%2C+M+A%3BReynolds%2C+C+W&rft.aulast=Ward&rft.aufirst=J&rft.date=1984-01-01&rft.volume=18&rft.issue=1&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Laboratory+animals&rft.issn=00236772&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-01-11 N1 - Date created - 2000-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantitative electron microscopic analysis of changes in peroxisomes and endoplasmic reticulum induced in mice during hepatocarcinogenesis by diethylnitrosamine promoted by di(2-ethylhexyl)phthalate or phenobarbital. AN - 75981088; 6599940 AB - Histochemical studies have shown that basophilic adenomas and carcinomas develop from basophilic foci in mice initiated with N-nitrosodiethylamine (DEN) and promoted by di(2-ethylhexyl)phthalate (DEHP), whereas eosinophilic liver tumors promoted by phenobarbital (PhB) arose from eosinophilic foci. In this experiment, the ultrastructure of tumorous and nontumorous areas of the liver from these two groups of mice was analyzed by quantitative morphometric methods. It is shown that nontumorous liver in DEN- and DEHP-treated mice demonstrate a pronounced proliferation of peroxisomes that is also present in liver tumors induced by DEHP alone but not in liver tumors after DEN initiation and DEHP promotion. Initiation with DEN and promotion with PhB resulted in pronounced proliferation of smooth endoplasmic reticulum (ER) in both tumorous and nontumorous liver, whereas the number of peroxisomes remained unchanged. JF - Journal of experimental pathology AU - Schuller, H M AU - Ward, J M AD - Pathology and Ultrastructural Oncology Section, National Cancer Institute, Bethesda, Maryland 20205. Y1 - 1984 PY - 1984 DA - 1984 SP - 287 EP - 294 VL - 1 IS - 4 SN - 0730-8485, 0730-8485 KW - Phthalic Acids KW - 0 KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - Diethylhexyl Phthalate KW - C42K0PH13C KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Animals KW - Mitochondria, Liver -- ultrastructure KW - Microscopy, Electron KW - Mice KW - Male KW - Liver Neoplasms, Experimental -- ultrastructure KW - Liver Neoplasms, Experimental -- chemically induced KW - Microbodies -- ultrastructure KW - Endoplasmic Reticulum -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75981088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+pathology&rft.atitle=Quantitative+electron+microscopic+analysis+of+changes+in+peroxisomes+and+endoplasmic+reticulum+induced+in+mice+during+hepatocarcinogenesis+by+diethylnitrosamine+promoted+by+di%282-ethylhexyl%29phthalate+or+phenobarbital.&rft.au=Schuller%2C+H+M%3BWard%2C+J+M&rft.aulast=Schuller&rft.aufirst=H&rft.date=1984-01-01&rft.volume=1&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+pathology&rft.issn=07308485&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-14 N1 - Date created - 1988-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A discussion of the stratigraphic sequence of the Kunyang Group and its correlation on the basis of the stromatolite assemblage isotopic ages AN - 51504280; 1984-038609 JF - Dizhi Lunping = Geological Review AU - Cao, Ruiji AU - Liang, Yuzuo AU - Duan, Jinsun Y1 - 1984 PY - 1984 DA - 1984 SP - 69 EP - 72 PB - [Geological Society of China], Beijing VL - 30 IS - 1 SN - 0371-5736, 0371-5736 KW - middle Precambrian KW - Far East KW - upper Precambrian KW - stratabound deposits KW - isotopes KW - Jixian System KW - Huaibei Group KW - lead KW - Kunyang Group KW - algae KW - stable isotopes KW - Luzijiang Formation KW - sedimentary rocks KW - radioactive isotopes KW - geochronology KW - dates KW - absolute age KW - Sinian KW - Asia KW - sedimentary structures KW - China KW - Pb-207/Pb-204 KW - Plantae KW - Dalongkou Formation KW - Precambrian KW - Pb-206/Pb-204 KW - biogenic structures KW - Proterozoic KW - correlation KW - stromatolites KW - metals KW - Liaonan Group KW - Yunnan China KW - Wumishan Formation KW - microfossils KW - 03:Geochronology KW - 12:Stratigraphy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51504280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dizhi+Lunping+%3D+Geological+Review&rft.atitle=A+discussion+of+the+stratigraphic+sequence+of+the+Kunyang+Group+and+its+correlation+on+the+basis+of+the+stromatolite+assemblage+isotopic+ages&rft.au=Cao%2C+Ruiji%3BLiang%2C+Yuzuo%3BDuan%2C+Jinsun&rft.aulast=Cao&rft.aufirst=Ruiji&rft.date=1984-01-01&rft.volume=30&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Dizhi+Lunping+%3D+Geological+Review&rft.issn=03715736&rft_id=info:doi/ LA - Chinese DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1984-01-01 N1 - Number of references - 5 N1 - Document feature - 1 plate N1 - Last updated - 2012-06-06 N1 - CODEN - TCLPAJ N1 - SubjectsTermNotLitGenreText - absolute age; algae; Asia; biogenic structures; China; correlation; Dalongkou Formation; dates; Far East; geochronology; Huaibei Group; isotopes; Jixian System; Kunyang Group; lead; Liaonan Group; Luzijiang Formation; metals; microfossils; middle Precambrian; Pb-206/Pb-204; Pb-207/Pb-204; Plantae; Precambrian; Proterozoic; radioactive isotopes; sedimentary rocks; sedimentary structures; Sinian; stable isotopes; stratabound deposits; stromatolites; upper Precambrian; Wumishan Formation; Yunnan China ER - TY - JOUR T1 - The stratigraphic division of the original Wulashan Group in the Wula Mountains, Nei Monggol (Inner Mongolia) AN - 51293514; 1986-004728 AB - The Archean strata in the Wula Mountains, Nei Mongol, were called the Sanggan Group in the early 1930s by Sun Jianchu. Based mainly on the Sheet Serial No.K-49-XXVI (Shetai Town Sheet), the strata were then formally named Wulashan Group in the "Regional Stratigraphic Tables of North China" (Nei Mongol Volume) published in 1978. This group is assumed to be Late Archean in age. It lies above the Jining Group (so called by Mr. Li Pu) in Jining area, but showing no direct contact with the latter. In recent studies of the early Precambrian metamorphic rock series in Nei Mongol, the authors have conducted a detailed regional investigation of the original Wulashan Group and measured its sections. The results showed that at the base of this group there are not only a granulite association corresponding to the upper part of the Dashiyao Formation of the original Jining Group but also a gneiss association characterized by silimanite-garnet gneiss, leuco-granulitite and graphitic gneiss corresponding to the Dabaiyao and Shajucun formations of the original Jining Group. Based on actual data and the analyses of the episodicity and cyclicity of crustal evolution, rock-forming pattern and characteristics of original rock formation, the above-mentioned two associations are divorced from the original Wulashan Group. The "granulite association" is renamed the Lower Jining Group and the "gneiss association" the Upper Jining Group, while the rest is still called the "Wulashan Group". The disintegrated original Wulashan Group is composed, in descending order, of the Wulashan Group, the Upper Jining Group and Lower Jining Group. The contacts between the newly established Upper and Lower Jining Group are inferred to be unconformable; the contacts between the Upper Jining Group and the Wulashan Group are found to be faulted in the Wula Mountains. The age of the earlier metamorphic phase in the area ranges from 2.4-2.5 b.y. It is evident that the rocks of the Wulashan Group were formed earlier than 2.5 b.y. ago, and its age undoubtedly belongs to Archean. JF - Regional Geology of China = Zhongquo Quyu Dizhi AU - Dong, Qixian AU - Zhou, Junchang Y1 - 1984 PY - 1984 DA - 1984 SP - 19 EP - 37 PB - People's Republic of China, Ministry of Geology and Mineral Resources, Beijing VL - 10 SN - 1000-3967, 1000-3967 KW - stratigraphy KW - Inner Mongolia China KW - lithostratigraphy KW - Far East KW - Precambrian KW - Wulashan Group KW - revision KW - Wula Mountains KW - Mulashan KW - metamorphic rocks KW - Jining Group KW - Archean KW - unconformities KW - Asia KW - China KW - 12:Stratigraphy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51293514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regional+Geology+of+China+%3D+Zhongquo+Quyu+Dizhi&rft.atitle=The+stratigraphic+division+of+the+original+Wulashan+Group+in+the+Wula+Mountains%2C+Nei+Monggol+%28Inner+Mongolia%29&rft.au=Dong%2C+Qixian%3BZhou%2C+Junchang&rft.aulast=Dong&rft.aufirst=Qixian&rft.date=1984-01-01&rft.volume=10&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Regional+Geology+of+China+%3D+Zhongquo+Quyu+Dizhi&rft.issn=10003967&rft_id=info:doi/ LA - Chinese DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by National Geological Library, Beijing, China N1 - Date revised - 1986-01-01 N1 - Number of references - 2 N1 - Document feature - 4 tables, sects. N1 - Last updated - 2012-06-06 N1 - SubjectsTermNotLitGenreText - Archean; Asia; China; Far East; Inner Mongolia China; Jining Group; lithostratigraphy; metamorphic rocks; Mulashan; Precambrian; revision; stratigraphy; unconformities; Wula Mountains; Wulashan Group ER - TY - JOUR T1 - Enzymes adsorbed on an ion exchanger as a post-column reactor: Application to acetylcholine measurement. AN - 14544240; 1431025 AB - Enzymes can be used in high-performance liquid chromatography post-column reactors to improve sensitivity of detection for some compounds by converting the compounds to easily detectable products. The enzymes can be covalently bound to a post-column reactor, but a simpler approach is to bind them by adsorption to an ion exchanger or a hydrophobic interaction support. This technique has been applied to electrochemical detection of acetylcholine by using adsorption of choline oxidase and cholinesterase to a 3-cm long commercially available weak anion-exchange cartridge. Conversion of acetylcholine to peroxide is quantitative during the 10-sec residence time in the cartridge. Enzyme elution from the cartridge is negligible when low ionic strength mobile phases are used. JF - Journal of Chromatography A AU - Meek, J L AU - Eva, C AD - Lab. Preclin. Pharmacol., NIMH, St. Elizabeths Hosp., Washington, DC 20032, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 343 EP - 347 VL - 317 SN - 0021-9673, 0021-9673 KW - acetylcholine KW - enzymes KW - high-performance liquid chromatography KW - use KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14544240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Enzymes+adsorbed+on+an+ion+exchanger+as+a+post-column+reactor%3A+Application+to+acetylcholine+measurement.&rft.au=Meek%2C+J+L%3BEva%2C+C&rft.aulast=Meek&rft.aufirst=J&rft.date=1984-01-01&rft.volume=317&rft.issue=&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Fast atom bombardment mass spectrometry and tandem mass spectrometry in antibiotics: Identification of nucleoside antitumor antibiotic toyocamycin in fermentation broth. AN - 14539478; 1434200 AB - The presence of the nucleoside antitumor antibiotic toyocamycin in the fermentation broth was determined by a combination of negative and positive ion fast atom bombardment (FAB) mass spectrometry, high resolution FAB mass spectrometry and mass-analysed ion kinetic energy spectrometry (MIKES). A reasonable limit of detection for toyocamycin in the whole broth was obtained by combining the specificity of mass spectrometry/mass spectrometry (also called tandem mass spectrometry) to FAB. The role played by the fermentation matrix upon the production and the observation of characteristic ions by FAB using xenon atoms was examined. High-performance liquid chromatography (HPLC) and FAB mass spectrometry were used to monitor toyocamycin at all stages of strain development, fermentation and recovery. JF - BIOMED. ENVIRON. MASS SPECTROM. AU - Tondeur, Y AU - Shorter, M AU - Gustafson, ME AU - Pandey, R C AD - Program Resources, Inc., NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 622 EP - 628 VL - 11 IS - 12 SN - 0887-6134, 0887-6134 KW - liquids KW - toyocamycin KW - Streptomyces KW - fermentation KW - mass spectroscopy KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - A 01013:Cytostatic & antitumor agents KW - J 02781:Biosynthesis and physicochemical properties KW - W 30410:Antibiotics and antitumor agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14539478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BIOMED.+ENVIRON.+MASS+SPECTROM.&rft.atitle=Fast+atom+bombardment+mass+spectrometry+and+tandem+mass+spectrometry+in+antibiotics%3A+Identification+of+nucleoside+antitumor+antibiotic+toyocamycin+in+fermentation+broth.&rft.au=Tondeur%2C+Y%3BShorter%2C+M%3BGustafson%2C+ME%3BPandey%2C+R+C&rft.aulast=Tondeur&rft.aufirst=Y&rft.date=1984-01-01&rft.volume=11&rft.issue=12&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=BIOMED.+ENVIRON.+MASS+SPECTROM.&rft.issn=08876134&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Streptomyces; fermentation; mass spectroscopy ER - TY - JOUR T1 - 2,3,7,8-Tetrachlorodibenzo-p-dioxin induced cleft palate in the mouse: Evidence for alterations in palatal shelf fusion. AN - 14344828; 1167274 AB - 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes a high percentage of cleft palate in fetuses when administered during organogenesis in certain strains of mice. The purpose of the present study was to examine various biochemical and morphological aspects of TCDD-induced changes in the developing palatal shelves. Examination of cryostat sections taken from embryos during the time of palatal elevation and fusion demonstrated that TCDD does not interfere with growth, elevation, or initial contact of the palatal shelves, but does interfere with firm adhesion and/or degeneration of the medial epithelial cells. Their results suggest that TCDD exerts a direct effect on the embryonic palatal shelves which results in formation of cleft palate. JF - Teratogenesis, Carcinogenesis and Mutagenesis AU - Pratt, R M AU - Denckern, L AU - Diewert, V M AD - Exp. Teratogenesis Sect., NIEHS, Natl. Inst. Health, MD C4-02, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 427 EP - 436 VL - 4 IS - 5 SN - 0270-3211, 0270-3211 KW - TCDD KW - cleft palate KW - mice KW - Toxicology Abstracts KW - embryos KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14344828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Teratogenesis%2C+Carcinogenesis+and+Mutagenesis&rft.atitle=2%2C3%2C7%2C8-Tetrachlorodibenzo-p-dioxin+induced+cleft+palate+in+the+mouse%3A+Evidence+for+alterations+in+palatal+shelf+fusion.&rft.au=Pratt%2C+R+M%3BDenckern%2C+L%3BDiewert%2C+V+M&rft.aulast=Pratt&rft.aufirst=R&rft.date=1984-01-01&rft.volume=4&rft.issue=5&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Teratogenesis%2C+Carcinogenesis+and+Mutagenesis&rft.issn=02703211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - embryos ER - TY - JOUR T1 - Increased urine histamine and contrast media reactions. AN - 14294746; 1121424 AB - Urine samples were collected from 200 subjects undergoing intravenous pyelography. Compared with normal controls, as a group, all subjects receiving intravenous contrast media had increased urine histamine while those subjects experiencing adverse reactions had considerably larger increases. The urine histamine levels in the subjects experiencing systemic reactions were in the same range as those observed in patients having mild anaphylactic reactions to immunotherapy and somewhat lower than those found in idiopathic anaphylaxis or systemic mastocytosis. The data suggest that some histamine release accompanies infusions of contrast media in all subjects and that larger amounts of histamine release are associated with adverse reactions. JF - Investigative Radiology AU - Kaliner, M AU - Dyer, J AU - Merlin, S AU - Shelton, A AU - Greenhill, A AU - Treadwell, G AU - McKenna, W AU - Lieberman, P AD - Allerg. Dis. Sect., NIAID, NIH, Build. 10, Room 11C-205, Bethesda, MD 20205, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 116 EP - 118 VL - 19 IS - 2 KW - association KW - reaction KW - histamine KW - Toxicology Abstracts KW - contrast media KW - urine KW - man KW - X 24117:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14294746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+Radiology&rft.atitle=Increased+urine+histamine+and+contrast+media+reactions.&rft.au=Kaliner%2C+M%3BDyer%2C+J%3BMerlin%2C+S%3BShelton%2C+A%3BGreenhill%2C+A%3BTreadwell%2C+G%3BMcKenna%2C+W%3BLieberman%2C+P&rft.aulast=Kaliner&rft.aufirst=M&rft.date=1984-01-01&rft.volume=19&rft.issue=2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Investigative+Radiology&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - contrast media; urine; man ER - TY - JOUR T1 - In vitro metabolism of mono-2-ethylhexyl phthalate by microsomal enzymes. Similarity to omega - and ( omega -1) oxidation of fatty acids. AN - 14277646; 1093630 AB - Mono-2-ethylhexyl pthalate (MEHP) is oxidized to omega -, omega -1, and omega -2-hydroxylation products as well as (very slightly) to a dicarboxylic acid by washed microsomes from rat liver and kidney, and rabbit but not rat lung. The reactions involve molecular oxygen, are strongly inhibited by carbon monoxide and oxidized cytochrome c, and NADPH is preferred over NADH. Piperonyl butoxide inhibits hydroxylation of MEHP, but clofibrate does not. The differential effects of inducers (phenobarbital and clofibrate) and inhibitors (sodium laurate, n-decane, metyrapone) on terminal and subterminal hydroxylation as well as differences in apparent K sub(m) for the two suggest that rat liver contains at least two different MEHP hydroxylases. Comparisons of tissue distribution, susceptibility to inhibitors, and induction properties suggest that the hydroxylation of MEHP is more likely to be mediated by the P-450 isozymes associated with omega - and ( omega -1)-hydroxylation of fatty acids than with those that utilize hydrocarbons as substrates. JF - Drug Metabolism and Disposition AU - Albro, P W AU - Chae, K AU - Philpot, R AU - Corbett, J T AU - Schroeder, J AU - Jordan, S AD - Lab. Mol. Biophys., N.I.E.H.S., Mail Drop 17-08, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 742 EP - 748 VL - 12 IS - 6 SN - 0090-9556, 0090-9556 KW - in vitro KW - enzymatic activity KW - mono-2-ethylhexyl phthalate KW - Toxicology Abstracts KW - animals KW - microsomes KW - metabolism KW - X 24153:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14277646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Metabolism+and+Disposition&rft.atitle=In+vitro+metabolism+of+mono-2-ethylhexyl+phthalate+by+microsomal+enzymes.+Similarity+to+omega+-+and+%28+omega+-1%29+oxidation+of+fatty+acids.&rft.au=Albro%2C+P+W%3BChae%2C+K%3BPhilpot%2C+R%3BCorbett%2C+J+T%3BSchroeder%2C+J%3BJordan%2C+S&rft.aulast=Albro&rft.aufirst=P&rft.date=1984-01-01&rft.volume=12&rft.issue=6&rft.spage=742&rft.isbn=&rft.btitle=&rft.title=Drug+Metabolism+and+Disposition&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - metabolism; microsomes; animals ER - TY - JOUR T1 - The effect of a sunscreen containing para-aminobenzoic acid on the systemic immunologic alterations induced in mice by exposure to UVB radiation. AN - 14266901; 1085557 AB - Application of a sunscreen containing para-aminobenzoic acid partially abrogated certain of the systemic immunologic alterations produced in mice by exposure to UVB (280-320 nm) radiation from sunlamp bulbs. The sunscreen reduced the degree of UVB-induced suppression of contact hypersensitivity to a chemical applied subsequently to nonirradiated skin. The tumor-susceptible state was transferred from animals treated with sunscreen and UVB radiation to lethally x-irradiated mice by injection of spleen cells. The gross morphology of the skin of mice treated with sunscreen and UVB radiation was normal but the histologic changes induced by UVB irradiation in skin were only partially abrogated by the sunscreen. JF - Journal of Investigative Dermatology AU - Morison, W L AD - NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 405 EP - 408 VL - 83 IS - 6 SN - 0022-202X, 0022-202X KW - effects on KW - p-aminobenzoic acid KW - mice KW - Toxicology Abstracts KW - U.V. radiation KW - immunology KW - sunscreens KW - X 24155:Biochemistry KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14266901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Investigative+Dermatology&rft.atitle=The+effect+of+a+sunscreen+containing+para-aminobenzoic+acid+on+the+systemic+immunologic+alterations+induced+in+mice+by+exposure+to+UVB+radiation.&rft.au=Morison%2C+W+L&rft.aulast=Morison&rft.aufirst=W&rft.date=1984-01-01&rft.volume=83&rft.issue=6&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Journal+of+Investigative+Dermatology&rft.issn=0022202X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - sunscreens; U.V. radiation; immunology ER - TY - JOUR T1 - Plasmid P1 replication: Negative control by repeated DNA sequences. AN - 14264105; 1087315 AB - The incompatibility locus, incA , of the unit-copy plasmid P1 is contained within a fragment that is essentially a set of nine 19-base-pair repeats. One or more copies of the fragment destabilizes the plasmid when present in trans. Here the authors show that extra copies of incA interfere with plasmid DNA replication and that a deletion of most of incA increases plasmid copy number. The in vivo results suggest that the repeating DNA sequence itself negatively controls replication by titrating a P1-determined protein, RepA, that is essential for replication. Consistent with this hypothesis is the observation that the RepA protein binds to the incA fragment in vitro. JF - Proceedings of the National Academy of Sciences, USA AU - Chattoraj, D AU - Cordes, K AU - Abeles, A AD - Lab. Genet. and Recombinant DNA, LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 6456 EP - 6460 VL - 81 IS - 20 SN - 0027-8424, 0027-8424 KW - plasmids P1 KW - repeated sequence KW - incA locus KW - regulation KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - replication KW - plasmids KW - loci KW - J 02760:Plasmids KW - G 07203:Plasmids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14264105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Plasmid+P1+replication%3A+Negative+control+by+repeated+DNA+sequences.&rft.au=Chattoraj%2C+D%3BCordes%2C+K%3BAbeles%2C+A&rft.aulast=Chattoraj&rft.aufirst=D&rft.date=1984-01-01&rft.volume=81&rft.issue=20&rft.spage=6456&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - plasmids; loci; replication ER - TY - JOUR T1 - Species differences in nitrosamine carcinogenesis. AN - 14220274; 1037703 AB - The carcinogenic action of approximately 50 N-nitroso compounds, nitrosamines, and nitrosoalkylamides has been compared in rats and in Syrian golden hamsters. The esophagus and other parts of the upper gastrointestinal tract were the most common sites for tumor induction in rats, but the esophagus was harldy ever affected in hamsters, although several compounds induced tumors of the forestomach in both rats and hamsters. Few generalizations can be made about these results, although it appeared that the 2-hydroxyproply group was usually necessary for the induction of pancreas tumors in hamsters. JF - Journal of Cancer Research and Clinical Oncology AU - Lijinsky, W AD - LBI-Basic Res. Program, Chem. Carcinog. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 46 EP - 55 VL - 108 IS - 1 SN - 0171-5216, 0171-5216 KW - nitrosamines KW - rats KW - hamsters KW - nitrosoalkylamides KW - Toxicology Abstracts KW - carcinogenesis KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14220274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cancer+Research+and+Clinical+Oncology&rft.atitle=Species+differences+in+nitrosamine+carcinogenesis.&rft.au=Lijinsky%2C+W&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1984-01-01&rft.volume=108&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cancer+Research+and+Clinical+Oncology&rft.issn=01715216&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenesis ER - TY - JOUR T1 - Carcinogenesis in F-344 rats by nitrosobis(2-oxopropyl) amine and related compounds administered in drinking water. AN - 14213431; 1038863 AB - Three asymmetric nitrosamines related to nitrosobis-(2-oxopropyl)-amine (BOP) were given to female F344 rats in drinking water to assess the significance of other alkyl groups on the carcinogenic expression by the 2-oxopropyl group. Nitroso-oxopropylethanolamine (OPE) was weakly carcinogenic, leading to little life-shortening and to induction of tumors (most of them liver neoplasm) in less than half of the treated animals. BOP induced a high incidence of hepatocellular carcinomas and hemangiosarcomas of the liver together with lung adenomas in most animals. Nitrosohydroxypropyl-oxopropylamine (HPOP) induced hepatocellular carcinomas, lung carcinomas, and carcinomas of the esophagus with a high incidence; life-shortening was greater with HPOP than with BOP. JF - Journal of Cancer Research and Clinical Oncology AU - Lijinsky, W AU - Saavedra, JE AU - Reuber, MD AD - LBI-Basic Res. Program, Chem. Carcinog. Program, NCI-Frederick Cancer Res. Fac., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 178 EP - 182 VL - 107 IS - 3 SN - 0171-5216, 0171-5216 KW - carcinogenesis KW - organs KW - specificity KW - structure-activity relationships KW - N-nitroso-bis(2-oxopropyl) amine KW - N-nitroso-oxopropylethanolamine KW - N-nitrosohydroxypropyl-oxopropylamine KW - N-nitrosodihydroxypropyl-oxopropylamine KW - rats KW - Toxicology Abstracts KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14213431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cancer+Research+and+Clinical+Oncology&rft.atitle=Carcinogenesis+in+F-344+rats+by+nitrosobis%282-oxopropyl%29+amine+and+related+compounds+administered+in+drinking+water.&rft.au=Lijinsky%2C+W%3BSaavedra%2C+JE%3BReuber%2C+MD&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1984-01-01&rft.volume=107&rft.issue=3&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cancer+Research+and+Clinical+Oncology&rft.issn=01715216&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - CONF T1 - Systemic administration of interleukin-2 in humans. AN - 14194881; 1031058 AB - Twelve patients were treated in a Phase I trial of purified human interleukin-2 (IL-2) derived from the JURKAT cell line (E.I. duPont Corp., Glenolden, PA U.S.A.). The serum half-life, toxicity, and in vivo immunologic effects of IL-2 were studied in patients with cancer unresponsive to standard therapy and in patients with acquired immunodeficiency syndrome (AIDS). Acute toxicity was minimal and consisted of headache (6 of 12), nausea (4 of 12), malaise (6 of 12), and fever and chills (8 of 12). No evidence of pulmonary, hematologic, or renal toxicity or any evidence of autoimmune phenomena was detected. A transient hyperbilirubinemia was seen in two patients receiving 2 mg purified IL-2. No demonstrable effect on tumors or chronic immunodeficiency (AIDS) was seen. No consistent chronic immunologic effects (natural killer or lymphokine-activated killer activity, mitogen responsiveness, total lymphocyte counts, or change in the porportion of various mononuclear cell phenotypes as defined by monoclonal antibody) were seenon a week-to-week basis during or following therapy. JF - J. BIOL. RESPONSE MODIF. AU - Lotze, M T AU - Robb, R J AU - Sharrow, SO AU - Frana, L W AU - Rosenberg, SA Y1 - 1984 PY - 1984 DA - 1984 SP - 475 EP - 582 VL - 3 IS - 5 KW - immunotherapy KW - Immunology Abstracts; Toxicology Abstracts KW - hyperbilirubinemia KW - side effects KW - immunostimulants KW - interleukin 2 KW - immunostimulation KW - man KW - carcinoma KW - acquired immune deficiency syndrome KW - F 06818:Cancer immunotherapy KW - F 06790:Clinical KW - F 06862:Other KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14194881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+BIOL.+RESPONSE+MODIF.&rft.atitle=Systemic+administration+of+interleukin-2+in+humans.&rft.au=Lotze%2C+M+T%3BRobb%2C+R+J%3BSharrow%2C+SO%3BFrana%2C+L+W%3BRosenberg%2C+SA&rft.aulast=Lotze&rft.aufirst=M&rft.date=1984-01-01&rft.volume=3&rft.issue=5&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=J.+BIOL.+RESPONSE+MODIF.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Chemical and serologic definition of two unique D region-encoded molecules in the wild-derived mouse strain B10.GAA37. AN - 14184081; 1020120 AB - Serologic analysis revealed that the antigens encoded by the D super(w16) region express a unique combination of specificites defined by monoclonal antibodies (mAb) with established activity for the L super(d) and D super(d) molecules. Two out of five ant-L super(d)-reactive mAb reacted with B10.GAA37 cells, whereas one of three anti-D super(d) mAb showed B10.GAA37 reactivity. Sequential immunoprecipitation of B10.GAA37 antigens demonstrated the existence of at least two antigenically distinct molecules (designated D super(w16) and L super(w16)) encoded by genes associated with the D super(w16) region. Peptide maps of the 2 molecules were compared. Comparison of these findings with the authors' previous studies of antigens encoded by the D regions suggest that each of these haplotypes has unique properties in terms of the number of gene products expressed and/or the structural relatedness of products of the same region. JF - Journal of Immunology AU - Lillehoj, E P AU - Walsh, W D AU - Potter, T AU - Lee AU - Coligan, JE AU - Hansen, TH AD - Lab. Immunogenet., Build. 5, Rm. B1-04, NIAID, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 3138 EP - 3142 VL - 133 IS - 6 SN - 0022-1767, 0022-1767 KW - D region KW - antigenic determinants KW - gene products KW - haplotypes KW - histocompatibility locus H-2 KW - mice KW - peptide mapping KW - proteins KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Immunology Abstracts KW - G 07240:Immunogenetics KW - F 06824:Animal KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14184081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Chemical+and+serologic+definition+of+two+unique+D+region-encoded+molecules+in+the+wild-derived+mouse+strain+B10.GAA37.&rft.au=Lillehoj%2C+E+P%3BWalsh%2C+W+D%3BPotter%2C+T%3BLee%3BColigan%2C+JE%3BHansen%2C+TH&rft.aulast=Lillehoj&rft.aufirst=E&rft.date=1984-01-01&rft.volume=133&rft.issue=6&rft.spage=3138&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - antigenic determinants; peptide mapping; gene products ER - TY - JOUR T1 - Radiation effects on cultured human monocytes and on monocyte-derived macrophages. AN - 14155089; 973681 AB - The authors assessed the effects of irradiation on the long-lived monocytes that have been shown to persist at inflammatory foci posttransfusion. Human monocytes were irradiated for up to 3 min. receiving 2,500-5,000 R. This irradiation damaged human monocytes, significantly decreasing their in vitro survival for the first 3 wk of culture, and growth. Despite smaller cell size, total cell protein was significantly increased over time in irradiated cultures. Extracellular lactate dehydrogenase (LDH) release was significantly increased after irradiation. Thus, the data indicate that irradiation in doses used to prevent graft-versus-host disease in leukocyte transfusion recipients has a deleterious effect on in vitro human monocyte survival and function. JF - Blood AU - Bueshcer, E S AU - Gallin, JI AD - Bact. Dis. Sect., Lab. Clin. Invest., NIAID, NIH, Bethesda, MD 20205, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 1402 EP - 1407 VL - 63 IS - 6 KW - effects on KW - release KW - lactate dehydrogenase KW - Immunology Abstracts; Toxicology Abstracts KW - immunosuppression KW - radiation KW - survival KW - monocytes KW - man KW - growth KW - X 24210:Radiation & radioactive materials KW - F 06791:Experimental UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14155089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Radiation+effects+on+cultured+human+monocytes+and+on+monocyte-derived+macrophages.&rft.au=Bueshcer%2C+E+S%3BGallin%2C+JI&rft.aulast=Bueshcer&rft.aufirst=E&rft.date=1984-01-01&rft.volume=63&rft.issue=6&rft.spage=1402&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - radiation; monocytes; survival; growth; man; immunosuppression ER - TY - JOUR T1 - Urolithiasis and bladder carcinogenicity of melamine in rodents. AN - 14107570; 935928 AB - Melamine (2,4,6-triamino-s-triazine) was administered in the diet to F344 rats or B6C3F sub(1) mice for 13 weeks (subchronic) or for 103 weeks (chronic) to determine its toxicologic profile, including carcinogenic potential in the chronic study. In these studies, compound-related lesions were observed in the urinary tract. Most noticeable was the development of uroliths (urinary bladder stones), which occurred at a greater frequency in males than females of either species. Increased incidences of urinary bladder stones and hyperplasia of the bladder epithelium were observed at 13 weeks in male rats fed diets containing melamine. In the chronic study, transitional-cell carcinomas in the urinary bladder of male rats occurred at a significantly (p less than or approximate to 0.016) higher incidence in the 4500 ppm (high dose) group (8/49) than in the controls (0/45). JF - Toxicology and Applied Pharmacology AU - Melnick, R L AU - Boorman, G A AU - Haseman, J K AU - Montali, R J AU - Huff, J AD - Natl. Toxicol. Program, NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 292 EP - 303 VL - 72 IS - 2 SN - 0041-008X, 0041-008X KW - chronic toxicity KW - rats KW - mice KW - melamine KW - Toxicology Abstracts; Calcium & Calcified Tissue Abstracts KW - urinary bladder KW - carcinogenicity KW - urinary tract KW - lithiasis KW - T 20074:Renal stones, nephrocalcinosis and lithiasis KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14107570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Urolithiasis+and+bladder+carcinogenicity+of+melamine+in+rodents.&rft.au=Melnick%2C+R+L%3BBoorman%2C+G+A%3BHaseman%2C+J+K%3BMontali%2C+R+J%3BHuff%2C+J&rft.aulast=Melnick&rft.aufirst=R&rft.date=1984-01-01&rft.volume=72&rft.issue=2&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - urinary tract; lithiasis; urinary bladder; carcinogenicity ER - TY - JOUR T1 - Induction of bacteriophage lambda by DNA-interacting chemicals. AN - 14101231; 934963 AB - Induction of resident prophages in coliform bacteria occurs as an indirect consequence of damage to the DNA of the host bacteria. The change in bacteriophage gene expression from the repressed to the active state (induction) is one of the manifestations of the "SOS response", among such others as mutagenesis, increased DNA repair activity, filamentation, and suppression of respiration. The SOS functions have in common the property of being controlled at the level of transcription by repressors that bind to DNA and prevent its expression. JF - Chemical Mutagens AU - Elespuru, R K AD - LBI-Basic Res. Prog., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 213 EP - 231 VL - 9 KW - induction KW - damage KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Toxicology Abstracts KW - ISBN 0-306-41696-4 KW - reviews KW - mutagenicity testing KW - phage lambda KW - DNA KW - prophages KW - N 14100:Reviews KW - N 14653:Effect of antibiotics, antimetabolites & mutagens KW - G 07220:General theory/testing systems KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14101231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Mutagens&rft.atitle=Induction+of+bacteriophage+lambda+by+DNA-interacting+chemicals.&rft.au=Elespuru%2C+R+K&rft.aulast=Elespuru&rft.aufirst=R&rft.date=1984-01-01&rft.volume=9&rft.issue=&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Chemical+Mutagens&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - phage lambda; prophages; mutagenicity testing; DNA; reviews ER - TY - JOUR T1 - Bulimia in men: Report of three cases with neuroendocrine findings. AN - 14100474; 922387 AB - Bulimia, like anorexia nervosa, primarily affects women. Although survey reports have shown that as many as 10%-13% of students meeting DSM-III criteria for bulimia are male, detailed clinical descriptions of male bulimic patients are rare. The following case reports describe three men seen for evaluation of bulimia at the UCLA Eating Disorders Clinic. JF - Journal of Clinical Psychiatry AU - Gwirtsman, HE AU - Roy-Byrne, P AU - Lerner, L AU - Yager, J AD - Lab. Clin. Sci., NIMH, Build. 10, Room 3S-231, 9000 Rockville Pike, Bethesda, MD 20205, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 78 EP - 81 VL - 45 IS - 2 SN - 0160-6689, 0160-6689 KW - men KW - bulimia KW - eating disorders KW - Health & Safety Science Abstracts KW - statistical analysis KW - surveys KW - H SM9.8.6:DIET KW - H SE4.8.6:DIET UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14100474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychiatry&rft.atitle=Bulimia+in+men%3A+Report+of+three+cases+with+neuroendocrine+findings.&rft.au=Gwirtsman%2C+HE%3BRoy-Byrne%2C+P%3BLerner%2C+L%3BYager%2C+J&rft.aulast=Gwirtsman&rft.aufirst=HE&rft.date=1984-01-01&rft.volume=45&rft.issue=2&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - surveys; statistical analysis ER - TY - JOUR T1 - Friction welding-contribution to technology economics through material, energy and time savings. AN - 14088875; 907707 AB - The paper outlines the benefits of friction welding and where and when to specify the process. The mechanism of the process is explained, as well as the different types of machines available. The engineer is shown how major savings can be made by correct utilization of the process. JF - FWP J. AU - Honey, C B AD - NEI Thompson Frict. Weld. Y1 - 1984 PY - 1984 DA - 1984 SP - 73 EP - 74,76+ VL - 24 IS - 9 KW - friction KW - tribology KW - economics KW - energy conservation KW - machinery KW - welding KW - Health & Safety Science Abstracts; Mechanical Engineering Abstracts (ISMEC) KW - H SI2.25:FRICTION, CORROSION, WEAR, TENSILE STRENGTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14088875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FWP+J.&rft.atitle=Friction+welding-contribution+to+technology+economics+through+material%2C+energy+and+time+savings.&rft.au=Honey%2C+C+B&rft.aulast=Honey&rft.aufirst=C&rft.date=1984-01-01&rft.volume=24&rft.issue=9&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=FWP+J.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - welding; machinery; economics; energy conservation ER - TY - JOUR T1 - The effect of 3-methyl substitution on the carcinogenicity of nitroso-4-piperidone. AN - 14018637; 847070 AB - The carcinogenic activity of the 3-methyl derivative of nitroso-4-piperidone was compared with that of the compound without the methyl group, by chronic administration to rats at equimolar doses in drinking water. Nitrosopiperidone induced both liver and esophageal tumors, whereas the 3-methyl derivative induced only tumors of the esophagus in a much shorter time. JF - Carcinogenesis AU - Singer, G M AU - Reuber, MD AU - Mangino, M M AU - Lijinsky, W AD - LBI-Basic Res. Program, Chem. Carcinog. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 1351 EP - 1353 VL - 5 IS - 10 SN - 0143-3334, 0143-3334 KW - comparison KW - N-nitroso-4-piperidone KW - N-nitroso-3-methyl-4-piperidone KW - rats KW - Toxicology Abstracts KW - carcinogenicity KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14018637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+effect+of+3-methyl+substitution+on+the+carcinogenicity+of+nitroso-4-piperidone.&rft.au=Singer%2C+G+M%3BReuber%2C+MD%3BMangino%2C+M+M%3BLijinsky%2C+W&rft.aulast=Singer&rft.aufirst=G&rft.date=1984-01-01&rft.volume=5&rft.issue=10&rft.spage=1351&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity ER - TY - JOUR T1 - Cloned Drosophila alcohol dehydrogenase genes are correctly expressed after transfection into Drosophila cells in culture. AN - 14006113; 832127 AB - The authors have obtained correct transcription of the cloned alcohol dehydrogenase (Adh ) gene of Drosophila melanogaster after DNA-mediated gene transfer into Drosophila cells in culture. Supercoiled plasmids, each containing various regions of the Adh gene cloned in pBR327, were introduced into Schneider line 2 (SL2) cells by the calcium phosphate-DNA transfection technique. Although these cells do not normally express their endogenous Adh genes, they do express the exogenous genes as shown by primer extension and nuclease S1 analyses of RNA isolated 48 hr after transfection. The resulting alcohol dehydrogenase (ADH) transcripts have the correct 5' ends and are properly spliced. The transfected cells have also acquired ADH enzyme activity. When a mutant Adh gene cloned from an ADH-negative mutant fly with a defect in the splicing of ADH RNA is transfected into the Schnider line 2 cells, the resulting ADH RNA is not spliced properly and there is no synthesis of ADH; thus, the mutant gene transfection into cell culture mimics the mutant phenotypes observed in the mutant fly. JF - Proceedings of the National Academy of Sciences, USA AU - Benyajati, C AU - Dray, J F AD - Lab. Mol. Biol., LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 1701 EP - 1705 VL - 81 IS - 6 SN - 0027-8424, 0027-8424 KW - Adh gene KW - alcohol dehydrogenase KW - Drosophila melanogaster KW - Drosophilidae KW - gene expression KW - genes KW - splicing KW - transformation KW - Entomology Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - G 07120:Recombinant DNA/Genetic engineering KW - Z 05216:Biochemical genetics KW - N 14684:Expression of cloned genes KW - N 14674:Transformation KW - W 30124:TRANSFORMATION KW - W 30133:EXPRESSION OF CLONED GENES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14006113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Cloned+Drosophila+alcohol+dehydrogenase+genes+are+correctly+expressed+after+transfection+into+Drosophila+cells+in+culture.&rft.au=Benyajati%2C+C%3BDray%2C+J+F&rft.aulast=Benyajati&rft.aufirst=C&rft.date=1984-01-01&rft.volume=81&rft.issue=6&rft.spage=1701&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Drosophila melanogaster; Drosophilidae; transformation; gene expression; splicing; genes ER - TY - JOUR T1 - Induction of tumours in rats by feeding nitrosatable amines together with sodium nitrite. AN - 14000646; 830950 AB - Feed containing 0.2% allantoin or diphenhydramine (as the hydrochloride) or 0.1% chlorpheniramine (as the maleate), with or without 0.2% sodium nitrite, was given ad lib. to groups of 20 or 24 male and 20 or 24 female F344 rats for 106 wk. Groups of 24 male and 24 female F344 rats were given drinking-water that contained N,N-dimethyldodecylamine-N-oxide at a concentration of 0.1%, with or without 0.2% sodium nitrite, for 93 wk. None of the four amines administered alone induced an increase in the incidence of any tumour in comparison with the untreated control groups. In the male rats given diphenhydramine, chlorpheniramine or N,N-dimethyldodecylamine-N-oxide concurrently with nitrite there was a significant increase in the incidence of liver neoplasms (hepatocellular carcinomas and neoplastic nodules). The number of male rats with liver tumours was ten in the group given dimethyldodecylamine-N-oxide plus nitrite, 11 in that given diphenhydramine plus nitrite and 14 (eight with carcinomas) in the group given chlorpheniramine plus nitrite. These results suggest that the ingestion of dimethyldodecylamine-N-oxide, diphenhydramine hydrochloride or chlorpheniramine under conditions when they could be nitrosated with nitrite in the stomach might present an increased carcinogenic risk. JF - Food and Chemical Toxicology AU - Lijinsky, W AD - LBI-Basic Res. Program, Chemical Carcinog. Lab., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 715 EP - 720 VL - 22 IS - 9 SN - 0278-6915, 0278-6915 KW - rats KW - sodium nitrite KW - diphenhydramine KW - chlorpheniramine KW - dimethyldodecylamine-N-oxide KW - Toxicology Abstracts KW - tumorigenicity KW - nitrosation KW - stomach KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14000646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Induction+of+tumours+in+rats+by+feeding+nitrosatable+amines+together+with+sodium+nitrite.&rft.au=Lijinsky%2C+W&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1984-01-01&rft.volume=22&rft.issue=9&rft.spage=715&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - tumorigenicity; nitrosation; stomach ER - TY - JOUR T1 - 7,12-Dimethylbenz(a)anthracene-DNA binding in mouse skin: Response of different mouse strains and effects of various modifiers of carcinogenesis. AN - 13997758; 824033 AB - 7,12-Dimethylbenz(a)anthracene (DMBA) - deoxyribonucleoside adducts formed in mouse skin DNA were quantified in order to determine whether these changed in any systematic fashion under conditions, where the tumorigenic activity of DMBA is modified. Similar distribution of adducts were found in male NIH Swiss mice and C57BL mice. Pretreatment with various chemicals known to inhibit the tumor initiating activity of DMBA in mouse skin did not lead to selective inhibition of the formation of any adduct in female NIH Swiss mice. The effects of these agents ranged from a clear inhibition of overall DNA binding (7,8-benzoflavone) to little or no effect on overall binding (butylated hydroxyanisole butylated hydroxytoluene). The lack of any effect of the antioxidants on DMBA - DNA adduct formation suggests that they may affect some step in tumor initiation othe than adduct formation. JF - Carcinogenesis AU - Dipple, A AU - Pigott, MA AU - Bigger, AH AU - Blake, D M AD - LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 1087 EP - 1090 VL - 5 IS - 8 SN - 0143-3334, 0143-3334 KW - adducts KW - inhibitors KW - effects on KW - strains KW - 9,10-dimethyl-1,2-benzanthracene KW - mice KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - DNA KW - tumors KW - N 14630:Chemical reactions & interactions, including effects of radiation KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13997758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=7%2C12-Dimethylbenz%28a%29anthracene-DNA+binding+in+mouse+skin%3A+Response+of+different+mouse+strains+and+effects+of+various+modifiers+of+carcinogenesis.&rft.au=Dipple%2C+A%3BPigott%2C+MA%3BBigger%2C+AH%3BBlake%2C+D+M&rft.aulast=Dipple&rft.aufirst=A&rft.date=1984-01-01&rft.volume=5&rft.issue=8&rft.spage=1087&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - DNA; tumors ER - TY - JOUR T1 - Gene fusion techniques: Cloning vectors for manipulating lacZ gene fusions. AN - 13979146; 819429 AB - A simple vector system for cloning gene fusions of lacZ is described. The authors apply one of these new vectors to the cloning and transcriptional analysis of the promoter region of the ompF gene of Escherichia coli . JF - GENE ANAL. TECH. AU - Berman, M L AU - Jackson, D AU - Fowler, A AU - Zabin, I AU - Christensen, L AU - Fill, N P AU - Hall, M N AD - Lab. Genet. and Recomb. DNA, LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 43 EP - 51 VL - 1 IS - 3 KW - construction KW - use KW - manipulation KW - ompF gene KW - lacZ gene KW - Escherichia coli KW - cloning KW - cloning vectors KW - gene fusion KW - genes KW - promoters KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - N 14682:Cloning vectors KW - W 30114:Cloning vectors KW - G 07120:Recombinant DNA/Genetic engineering KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13979146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=GENE+ANAL.+TECH.&rft.atitle=Gene+fusion+techniques%3A+Cloning+vectors+for+manipulating+lacZ+gene+fusions.&rft.au=Berman%2C+M+L%3BJackson%2C+D%3BFowler%2C+A%3BZabin%2C+I%3BChristensen%2C+L%3BFill%2C+N+P%3BHall%2C+M+N&rft.aulast=Berman&rft.aufirst=M&rft.date=1984-01-01&rft.volume=1&rft.issue=3&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=GENE+ANAL.+TECH.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; gene fusion; cloning vectors; promoters; cloning; genes ER - TY - JOUR T1 - Systemic suppression of contact hypersensitivity by UVB radiation is unrelated to the UVB-induced alterations in the morphology and number of Langerhans cells. AN - 13973161; 804458 AB - Exposure of mice of UVB (280-320 nm) ultraviolet radiation reduces contact hypersensitivity (CHS) reaction to chemicals that are applied subsequently to unirradiated skin. It also decreases the number and alters the morphology of Langerhans cells at the site of irradiation. The authors addressed the question of whether the systemic suppression of CHS was related to these modifications of Langerhans cells by UVB radiation. In mice treated on the dorsum with UVB radiation, the number and morphology of Langerhans cells in the unexposed areas of skin used for inducing and eliciting CHS appeared normal. Therefore, the depression of CHS could not be attributed to a depletion of Langerhans cells at the sites of application of the sensitizing agent. It was concluded that systemic suppression of CHS by UVB irradiation is not related to the numerical and morphological alterations in Langerhans cells that occur locally at the site of irradiation. JF - Immunology AU - Morison, W L AU - Bucana, C AU - Kripke, M L AD - NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 299 EP - 306 VL - 52 IS - 2 SN - 0019-2805, 0019-2805 KW - relationship KW - morphology KW - mice KW - Toxicology Abstracts; Immunology Abstracts KW - Langerhans cells KW - immunosuppression KW - U.V. radiation KW - contact dermatitis KW - X 24210:Radiation & radioactive materials KW - F 06846:Clinical KW - F 06791:Experimental UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13973161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=Systemic+suppression+of+contact+hypersensitivity+by+UVB+radiation+is+unrelated+to+the+UVB-induced+alterations+in+the+morphology+and+number+of+Langerhans+cells.&rft.au=Morison%2C+W+L%3BBucana%2C+C%3BKripke%2C+M+L&rft.aulast=Morison&rft.aufirst=W&rft.date=1984-01-01&rft.volume=52&rft.issue=2&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=00192805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - U.V. radiation; immunosuppression; contact dermatitis; Langerhans cells ER - TY - JOUR T1 - Selection of lac gene fusions in vivo: ompR-lacZ fusions that define a functional domain of the ompR gene product. AN - 13971817; 807725 AB - The authors describe a simple method for selecting Escherichia coli mutants that carry gene fusions between a cloned gene and lacZ . This technique with the ompR gene, which codes for a positive regulatory factor in porin synthesis. A number of OmpR-LacZ hybrid proteins are examined, and several unusual phenotypes associated with these protein fusions are described. Evidence is presented to support the two-domain model for ompR proposed previously (Hall and Silhavy, J. Mol. Biol. 151:1-15) In addition, one of the ompR-lacZ fusions exhibits a dominant OmpR super(-) phenotype. The utility of isolating a series of lacZ) gene fusions to any target gene is discussed. JF - Journal of Bacteriology AU - Berman, M L AU - Jackson, DE AD - Lab. Genet. and Recomb. DNA, LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil. Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 750 EP - 756 VL - 159 IS - 2 SN - 0021-9193, 0021-9193 KW - ompR gene KW - lacZ gene KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - gene fusion KW - genes KW - mutants KW - Escherichia coli KW - G 07120:Recombinant DNA/Genetic engineering KW - N 14679:Others KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13971817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Selection+of+lac+gene+fusions+in+vivo%3A+ompR-lacZ+fusions+that+define+a+functional+domain+of+the+ompR+gene+product.&rft.au=Berman%2C+M+L%3BJackson%2C+DE&rft.aulast=Berman&rft.aufirst=M&rft.date=1984-01-01&rft.volume=159&rft.issue=2&rft.spage=750&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; mutants; gene fusion; genes ER - TY - JOUR T1 - Gears for pumped-storage units. AN - 13943469; 784517 AB - Investigations on the application of gearing for pumped-storage installations, conducted by the authors' company, is described. It is demonstrated that the installation of a coaxial epicyclic gear between the pump-turbine and the motor-generator could allow for more efficient runner operation, because of the option of using two speeds. JF - International Water Power and Dam Construction AU - Marsh, B J AU - Lack, G L AD - NEI-A.P.E.-Allen Gears Ltd., Pershore, Worcestershire, WR10 2BZ, UK Y1 - 1984 PY - 1984 DA - 1984 SP - 37 EP - 38 VL - 36 IS - 8 SN - 0306-400X, 0306-400X KW - generators KW - gears KW - internal combustion engines KW - pumping stations KW - storage KW - Mechanical Engineering Abstracts (ISMEC); Health & Safety Science Abstracts KW - H SI5.20:ELECTRIC POWER INDUSTRIES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13943469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Water+Power+and+Dam+Construction&rft.atitle=Gears+for+pumped-storage+units.&rft.au=Marsh%2C+B+J%3BLack%2C+G+L&rft.aulast=Marsh&rft.aufirst=B&rft.date=1984-01-01&rft.volume=36&rft.issue=8&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=International+Water+Power+and+Dam+Construction&rft.issn=0306400X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - pumping stations; internal combustion engines; storage ER - TY - JOUR T1 - Effects of acute administration of caffeine on local cerebral glucose utilization in the rat. AN - 13935154; 783281 AB - The quantitative 2-( super(14)C)deoxyglucose autoradiographic method was used to study the effects of acute intravenous injections (15 min prior to study) of caffeine on brain energy metabolism. With doses of 0.1 mg/kg the effects of caffeine on cerebral glucose utilization were limited to the habenula, spinal trigeminal and paraventricular nuclei. After the 1.0 mg/kg dose significant increases were additionally seen in the caudate ventral tegmental area and medial septum. After the injections of 10 mg/kg of caffeine, average glucose utilization of the brain as a whole was increased by 15%, and of 71 structures examined 31 structures were statistically significantly affected. This study demonstrates that there is a correlation between the known stimulant effects of caffeine on behavior and widespread increases in glucose utilization throughout the brain. JF - European Journal of Pharmacology AU - Nehlig, A AU - Lucignani, G AU - Kadekaro, M AU - Porrino, L J AU - Sokoloff, L AD - Lab. Cerebral Metabl., NIMH, Build. 36, Room 1A-27, 9000 Rockville Pike, Bethesda, MD 20205, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 91 EP - 100 VL - 101 IS - 1-2 SN - 0014-2999, 0014-2999 KW - acute effects KW - rats KW - caffeine KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - glucose metabolism KW - stimulants KW - cerebrum KW - N3 11094:Central nervous system KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13935154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Pharmacology&rft.atitle=Effects+of+acute+administration+of+caffeine+on+local+cerebral+glucose+utilization+in+the+rat.&rft.au=Nehlig%2C+A%3BLucignani%2C+G%3BKadekaro%2C+M%3BPorrino%2C+L+J%3BSokoloff%2C+L&rft.aulast=Nehlig&rft.aufirst=A&rft.date=1984-01-01&rft.volume=101&rft.issue=1-2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - glucose metabolism; cerebrum; stimulants ER - TY - JOUR T1 - P1 plasmid replication: Replicon structure. AN - 13933353; 772844 AB - Bacteriophage P1 lysogenizes Escherichia coli as a unit-copy plasmid. The authors have undertaken to define the plasmid-encoded elements implicated in P1 plasmid maintenance. They show that a 2081 base-pair fragment of the 90,000 base P1 plasmid confers the capacity for controlled plasmid replication. DNA sequence analysis reveals several open reading frames in this fragment. The largest is shown to encode a 32,000 M sub(r) protein required for plasmid replication. The corresponding gene, rep)A, has been identified genetically. A set of five 19 base-pari repeats is located upstream from from rep A: a set of nine similar repeats is located immediately downstream from rep A. JF - Journal of Molecular Biology AU - Abeles, AL AU - Snyder, K M AU - Chattoraj, D K AD - Lab. Mol. Biol., LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 307 EP - 324 VL - 173 IS - 3 SN - 0022-2836, 0022-2836 KW - plasmid P1 KW - structure KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - phage P1 KW - nucleotide sequence KW - prophages KW - plasmids KW - copy number control KW - N 14640:Structure & sequence KW - G 07311:PHAGES-INITIAL NAMES KW - J 02760:Plasmids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13933353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=P1+plasmid+replication%3A+Replicon+structure.&rft.au=Abeles%2C+AL%3BSnyder%2C+K+M%3BChattoraj%2C+D+K&rft.aulast=Abeles&rft.aufirst=AL&rft.date=1984-01-01&rft.volume=173&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - phage P1; plasmids; copy number control; nucleotide sequence; prophages ER - TY - CONF T1 - Pilot- and production-scale containment of cytotoxic and oncogenic fermentation processes. AN - 13929441; 779297 AB - Proper design of fermentation facilities and equipment modification can control the risks associated with large-scale production and purification of microbially produced cytotoxic agents and oncogenic viruses. The primary biohazard risks to operators and the environment are generation of aerosols and accidental spills. Fermentation and recovery facilities can be constructed to contain these agents by installing fermentation equipment within a HEPA-filter-exhausted biological barrier. Within this barrier system, large-scale processing that generates potentially hazardous aerosols (filtration, centrifugation of transformed cells or crystal slurries, and banding of viruses) should be isolated from other operations. JF - Biotechnology and Bioengineering AU - Flickinger, M C AU - Sansone, E B Y1 - 1984 PY - 1984 DA - 1984 SP - 860 EP - 870 VL - 26 IS - 8 KW - production KW - risks KW - occupational exposure KW - filtration KW - reduction KW - DNA tumor viruses KW - aerosols KW - antitumor antibiotics KW - fermenters KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - A 01013:Cytostatic & antitumor agents KW - A 01114:Viruses KW - V 22022:Virus assay KW - W 30310:Microorganisms KW - W 30410:Antibiotics and antitumor agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13929441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Bioengineering&rft.atitle=Pilot-+and+production-scale+containment+of+cytotoxic+and+oncogenic+fermentation+processes.&rft.au=Flickinger%2C+M+C%3BSansone%2C+E+B&rft.aulast=Flickinger&rft.aufirst=M&rft.date=1984-01-01&rft.volume=26&rft.issue=8&rft.spage=860&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Bioengineering&rft.issn=00063592&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Correlation of dose-dependent effects of acute amphetamine administration on behavior and local cerebral metabolism in rats. AN - 13928278; 770136 AB - Rates of local cerebral glucose utilization were measured by means of the quantitative autoradiographic 2-( super(14)C)deoxyglucose technique in conscious rats following the acute administration of D-amphetamine. Changes in locomotor and stereotypic behavior in similarly treated rats were examined as well. The data demonstrate that the acute administration of D-amphetamine produces effects on local cerebral glucose utilizaiton and on behavior that differ with dose. The results also show a strong coupling between locomotion and the level of metabolic activity in the nucleus accumbens and demonstrate that the different forms of stereotypic behavior elicited by high and moderate doses of amphetamine are correlated with distinct patterns of distribution of local cerebral glucose utilization, indicating mediation by different neuronal circuits. JF - Brain Research AU - Porrino, L J AU - Lucignani, G AU - Dow-Edwards, D AU - Sokoloff, L AD - Lab. Cereb. Metab., NIMH, 36/1A-27, 9000 Rockville Pike, Bethesda, MD 20205, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 311 EP - 320 VL - 307 IS - 1-2 SN - 0006-8993, 0006-8993 KW - effects on KW - relationship KW - amphetamine KW - rats KW - Toxicology Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - analgesics KW - locomotor activity KW - glucose metabolism KW - stereotyped behavior KW - brain KW - N3 11138:Pharmacological correlates KW - Y 25667:Mammals (excluding primates) KW - X 24111:Acute exposure KW - Y 25817:Mammals (excluding primates) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13928278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Correlation+of+dose-dependent+effects+of+acute+amphetamine+administration+on+behavior+and+local+cerebral+metabolism+in+rats.&rft.au=Porrino%2C+L+J%3BLucignani%2C+G%3BDow-Edwards%2C+D%3BSokoloff%2C+L&rft.aulast=Porrino&rft.aufirst=L&rft.date=1984-01-01&rft.volume=307&rft.issue=1-2&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - glucose metabolism; locomotor activity; stereotyped behavior; brain; analgesics ER - TY - JOUR T1 - Age dependent pharmacokinetic changes of ethylenediamine in Fischer 344 rats parallel to a two-year chronic toxicity study. AN - 13924794; 770593 AB - As part of a 2-year chronic toxicity study, the pharmacokinetics of ethylenediamine (EDA) was studied in Fischer 344 rats of both sexes at day zero (naive animals). A single per os (po) dose of 50 mg ( super(14))EDA multiplied by 2HCl/kg was given to each rat and the plasma kinetics was followed for a 24-hr period. Five pharmacokinetic parameters (absorption rate constant terminal half-life, area under the curve, volume of distribution, and super(14)CO sub(2) production rate constant) were compared with respect to age, sex, and chronic dosing. There were no apparent age-, sex-, and/or chronic dosing-related differences in absorption rate constant and terminal half-life. However, age-related changes in area under the curve (AUC) were evident. The older rats had higher values (generally two- to threefold) for AUC than the younger rats. JF - Fundamental and Applied Toxicology AU - Yang, RSH AU - Tallant, MJ AU - McKelvey, JA AD - NIEHS/NTP, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 663 EP - 670 VL - 4 IS - 4 SN - 0272-0590, 0272-0590 KW - pharmacokinetics KW - chronic exposure KW - effects on KW - rats KW - ethylenediamine KW - Toxicology Abstracts KW - age KW - X 24153:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13924794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+Applied+Toxicology&rft.atitle=Age+dependent+pharmacokinetic+changes+of+ethylenediamine+in+Fischer+344+rats+parallel+to+a+two-year+chronic+toxicity+study.&rft.au=Yang%2C+RSH%3BTallant%2C+MJ%3BMcKelvey%2C+JA&rft.aulast=Yang&rft.aufirst=RSH&rft.date=1984-01-01&rft.volume=4&rft.issue=4&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+Applied+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - age ER - TY - JOUR T1 - Interferon- gamma : Early studies and potential applications. AN - 13916948; 760017 AB - The authors have used an IFN- gamma preparation prepared from the supernatant of cells derived from peripheral blood leukocytes chemically stimulated to produce IFN- gamma . This preparation was then utilized in an escalating dose phase I trial to determine its biologic effects, including toxicity, immunomodulating capability, and pharmacokinetics. Despite the major differences between IFN- alpha preparations, many of the toxicities, immunologic modulating effects, and therapeutic effects have been similar. Fever, chills, headache, fatigue, and anorexia have been constant side effects while, at higher doses, mild hematologic depression and transient hepatic enzyme abnormalities have been seen. Occasional cardiac effects, including arrhythmias and ischemic episodes, have been observed and some central nervous system (CNS) toxicity, including confusion, decreased ability to concentrate and, rarely, seizures at very high doses have been observed during these studies. It is unclear if the cardiac and CNS effects are due to the direct action of the IFN. JF - Clinical Immunology Newsletter AU - Oldham, R K AU - Smalley, R V AD - Biol. Respir. Modifiers Program, Div. Cancer Treat., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 69 EP - 73 VL - 5 IS - 5 SN - 0197-1859, 0197-1859 KW - antiviral activity KW - clinical trials KW - Toxicology Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - side effects KW - immunomodulation KW - gamma -interferon KW - man KW - F 06818:Cancer immunotherapy KW - V 22095:Interferon KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13916948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Immunology+Newsletter&rft.atitle=Interferon-+gamma+%3A+Early+studies+and+potential+applications.&rft.au=Oldham%2C+R+K%3BSmalley%2C+R+V&rft.aulast=Oldham&rft.aufirst=R&rft.date=1984-01-01&rft.volume=5&rft.issue=5&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Clinical+Immunology+Newsletter&rft.issn=01971859&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - gamma -interferon; immunomodulation; side effects; man ER - TY - JOUR T1 - Antiviral drugs. AN - 13910152; 759920 AU - Galasso, G J AD - NIAID, Natl. Inst. Health, Build. WB, Rm. 750, Bethesda, MD 20205, USA A2 - Notkins, AL A2 - Oldstone, MBA (eds) Y1 - 1984 PY - 1984 DA - 1984 SP - 382 EP - 388 KW - antiviral activity KW - characterization KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - reviews KW - antiviral agents KW - viruses KW - A 01068:Antiviral & viricidal KW - V 22100:Antiviral agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13910152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Industrial+and+Applied+Microbiology+Abstracts+%28Microbiology+A%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Galasso%2C+G+J&rft.aulast=Galasso&rft.aufirst=G&rft.date=1984-01-01&rft.volume=&rft.issue=&rft.spage=382&rft.isbn=0387909826&rft.btitle=Antiviral+drugs.&rft.title=Antiviral+drugs.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - viruses; antiviral agents; reviews ER - TY - JOUR T1 - Tubulin tyrosinolated in vivo can be different from that tyrosinolated in vitro. AN - 13907609; 755686 AB - Tubulin can be tyrosinolated, in the presence of ATP, by tubulin-tyrosine ligase, and tyrosine can be released by the same enzyme in the presence of ADP plus inorganic phosphate. There is however a "non-substrate" component of tubulin which can not be tyrosinolated or detyrosinolated by this enzyme. Tubulin tyrosinolated in vivo was found to be the non-substrate species in HeLa cells, and the substrate species in cultured neuronal cells. In this respect HeLa tubulin resembled membrane-associated tubulin from brain, and neuronal cell tubulin resembled brain cytosolic tubulin. JF - Biochimica et Biophysica Acta: Protein Structure and Molecular Enzymology AU - Nath, J AU - Flavin, M AD - Lab. Cell Biol., N.H.L.B.I., Build. 3, Rm. B1-22, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 314 EP - 322 VL - 803 IS - 4 SN - 0167-4838, 0167-4838 KW - tubulin KW - tubulin-tyrosine ligase KW - tyrosinolation KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13907609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+Biophysica+Acta%3A+Protein+Structure+and+Molecular+Enzymology&rft.atitle=Tubulin+tyrosinolated+in+vivo+can+be+different+from+that+tyrosinolated+in+vitro.&rft.au=Nath%2C+J%3BFlavin%2C+M&rft.aulast=Nath&rft.aufirst=J&rft.date=1984-01-01&rft.volume=803&rft.issue=4&rft.spage=314&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+Biophysica+Acta%3A+Protein+Structure+and+Molecular+Enzymology&rft.issn=01674838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Antibody-independent C1 activation by E. coli . AN - 13905199; 750589 AB - Antibody-independent interactions of C1 with several E. coli strains were examined. Purified C1 was directly activated by the semi-rough mutant E. coli J-5, its parental wild-type strain, E. coli 0111:B4, and two clinical isolates, E. coli (P) and E. coli (A), in the absence of C1 inhibitor E. coli J-5 activated C1 about 10-fold more rapidly and bound approximately threefold more C1 than the other strains. E. coli J-5, but not the other strains, also bound C1s sub(2), provided that the subcomponent was offered to the bacteria in the presence of C1q and calcium; such binding was thus independent of the presence or absence of C1r sub(2). After C1 activation in the absence of C1 inhibitor, activated C1s spontaneously dissociated from E. coli) 0111:B4, (P), and (A), but remained associated with E. coli J-5. The studies thus indicate that several E. coli strains are direct C1 activators. Furthermore, E. coli J-5 provides another example of a direct C1 activator having binding sites not only for C1q but also for dimeric C1s. The studies also show that there are multiple properties of particles which determine the ability to activate C1, the rate of activation, the possibility of regulation of the activation process by C1 inhibitor, and the fate of activated C1. JF - Journal of Immunology AU - Tenner, A J AU - Ziccardi, R J AU - Cooper, N R AD - Lab. Clin. Invest. NIAID, NIH, Bethesda, MD 20205, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 886 EP - 891 VL - 133 IS - 2 SN - 0022-1767, 0022-1767 KW - activation KW - mechanisms KW - factors affecting KW - in vitro KW - complement component C1 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Escherichia coli KW - F 06087:Function KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13905199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Antibody-independent+C1+activation+by+E.+coli+.&rft.au=Tenner%2C+A+J%3BZiccardi%2C+R+J%3BCooper%2C+N+R&rft.aulast=Tenner&rft.aufirst=A&rft.date=1984-01-01&rft.volume=133&rft.issue=2&rft.spage=886&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli ER - TY - JOUR T1 - Temporal dissociation in the exposure times required for maximal induction of cytotoxicity, mutation, and transformation by N-methyl-N'-nitro-N-nitrosoguanidine in the BALB/3T3 CIA31-1-1 cell line. AN - 13902611; 753433 AB - Cytotoxicity, alkali-labile DNA lesions, ouabain resistance mutations, and neoplastic transformation were analyzed concurrently in the BALB/3T3 CIA31-1-1 cell line treated with the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for different exposure times (15, 30, 60, 90, 120, and 240 min; 24, 48, and 72 hr). The temporal dissociation in the exposure times for maximal induction of mutation and transformation, observed with MNNG in this cell line, supports the hypothesis that a single gene mutational event is not sufficient to account for the full expression of neoplastic transformation. JF - Cancer Research AU - Bignami, M AU - Ficorella, C AU - Dogliotti, E AU - Norman, R L AU - Kaighn, ME AU - Saffiotti, U AD - Lab. Exp. Pathol., NCI-FCRF, Build. 560, Rm. 32-60, Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 2452 EP - 2457 VL - 44 IS - 6 SN - 0008-5472, 0008-5472 KW - cell lines KW - mutagenicity KW - mechanisms KW - mice KW - N-nitroso-N-methyl-N'-nitroguanidine KW - Genetics Abstracts; Toxicology Abstracts KW - X 24200:Nitrosamines & related compounds KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13902611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Temporal+dissociation+in+the+exposure+times+required+for+maximal+induction+of+cytotoxicity%2C+mutation%2C+and+transformation+by+N-methyl-N%27-nitro-N-nitrosoguanidine+in+the+BALB%2F3T3+CIA31-1-1+cell+line.&rft.au=Bignami%2C+M%3BFicorella%2C+C%3BDogliotti%2C+E%3BNorman%2C+R+L%3BKaighn%2C+ME%3BSaffiotti%2C+U&rft.aulast=Bignami&rft.aufirst=M&rft.date=1984-01-01&rft.volume=44&rft.issue=6&rft.spage=2452&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Sequence of guinea pig myelin basic protein. AN - 13901024; 752004 AB - This paper proposes a tentative amino acid sequence of guinea pig myelin basic protein obtained by comparison of peptide fragments of the guinea pig and bovine proteins. Analyses of the tryptic peptides showed that in the COOH-terminal half of the guinea pig protein Ser super(131) was missing, Ala super(136)-His super(137) was deleted, Leu super(140) was replaced by Phe, and an extra Ala was inserted somewhere within sequence 142-151 (tryptic peptide T23). Sequence determination of guinea pig tryptic peptides confirmed the above sequence changes and placed the extra Ala between Gly super(142) and His super(143). The sequence of the region corresponding to bovine residues 130-143 is thus Ala-Asp-Tyr-Lys-Ser-Lys-Gly-Phe-Lys-Gly-Ala-His. Based upon these results, the guinea pig basic protein contains 167 amino acid residues and has a molecular weight of 18,256. JF - Journal of Neurochemistry AU - Deibler, GE AU - Martenson, R E AU - Krutzsch, H C AU - Kies, M W AD - Lab. Cerebr. Metab., NIMH, Build. 36, Rm. 1A-27, 9000 Rockville Pike, Bethesda, MD 20205, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 100 EP - 105 VL - 43 IS - 1 SN - 0022-3042, 0022-3042 KW - amino acid sequence KW - guinea-pigs KW - myelin basic protein KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - N3 11070:Neurochemistry and cellular biology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13901024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Sequence+of+guinea+pig+myelin+basic+protein.&rft.au=Deibler%2C+GE%3BMartenson%2C+R+E%3BKrutzsch%2C+H+C%3BKies%2C+M+W&rft.aulast=Deibler&rft.aufirst=GE&rft.date=1984-01-01&rft.volume=43&rft.issue=1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - amino acid sequence ER - TY - JOUR T1 - Carcinogenesis by nitrosomorpholines, nitrosooxazolidines and nitrosoazetidine given by gavage to Syrian golden hamsters. AN - 13900748; 754005 AB - Five cyclic nitrosamines, four containing oxygen in the ring, were administered by gavage to groups of 20 male Syrian golden hamsters. After administration of very similar doses, nitrosomorpholine, nitroso-2-methylmorpholine and nitroso-5-methyl-1,3-oxazolidine caused the animals to die with tumors after similar times, but nitrosomorpholine induced mainly tumors of the nasal cavity, whereas the 2-methyl derivative induced tumors of the nasal cavity and liver. While nitroso-1,3-oxazolidine and its 5-methyl derivative both induced liver tumors those induced by the former compound took much longer to kill the animals. Nitrosoazetidine, a liver carcinogen in rats, but which had been reported to be inactive in hamsters, did induce tumors of the liver in 30% of hamsters after a much larger dose than the other cyclic nitrosamines. JF - Carcinogenesis AU - Lijinsky, W AU - Kovatch, R M AU - Knutsen, G L AD - LBI-Basic Res. Program, Chem. Carcinog. Lab., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 875 EP - 878 VL - 5 IS - 7 SN - 0143-3334, 0143-3334 KW - hamsters KW - N-nitroso-2-methylmorpholine KW - N-nitroso-5-methyl-1,3-oxazolidine KW - N-nitrosomorpholine KW - N-nitrosoazetidine KW - Toxicology Abstracts KW - tumorigenicity KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13900748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Carcinogenesis+by+nitrosomorpholines%2C+nitrosooxazolidines+and+nitrosoazetidine+given+by+gavage+to+Syrian+golden+hamsters.&rft.au=Lijinsky%2C+W%3BKovatch%2C+R+M%3BKnutsen%2C+G+L&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1984-01-01&rft.volume=5&rft.issue=7&rft.spage=875&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - tumorigenicity ER - TY - JOUR T1 - lacZ fusions to genes that specify exported proteins: A general technique. AN - 13891774; 737261 AB - In this paper, the authors describe a general method for the construction of fusions between genes that specify exported proteins and lacZ . This method employs a MudII(lac,.Ap) derivative with an early amber mutation in lacZ and a conditional amber suppressor. Since this method allows the construction of strains in which expression of a lethal hybrid protein can be controlled by changing growth temperature, it should also provide a direct selection for mutants that fail to export the target gene product. JF - Molecular and General Genetics AU - Palva, E T AU - Silhavy, T J AD - Lab. Genet. and Recomb. DNA, LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 388 EP - 394 VL - 194 IS - 3 SN - 0026-8925, 0026-8925 KW - lacZ gene KW - methodology KW - beta -D-galactosidase KW - gene fusion KW - genes KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - W 30114:Cloning vectors KW - N 14682:Cloning vectors KW - G 07120:Recombinant DNA/Genetic engineering KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13891774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+General+Genetics&rft.atitle=lacZ+fusions+to+genes+that+specify+exported+proteins%3A+A+general+technique.&rft.au=Palva%2C+E+T%3BSilhavy%2C+T+J&rft.aulast=Palva&rft.aufirst=E&rft.date=1984-01-01&rft.volume=194&rft.issue=3&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=Molecular+and+General+Genetics&rft.issn=00268925&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - gene fusion; genes ER - TY - JOUR T1 - Characteristics of amplifier T cells involved in the antibody response to the capsular polysaccharide of type III Streptococcus pneumoniae . AN - 13888714; 750461 AB - Amplifier T cell activity can be transferred by spleen cells harvested 72 hr after priming with type III pneumococcal polysaccharide (SSS-III) and can be abolished by treating the transferred cells with monoclonal anti-Lyt-1, or anti-Thy-1 antibodies in the presence of complement; thus, amplifier cells represent a distinct subpopulation of T cells. Amplifier T cells were found to be sensitive to irradiation but not to treatment with cyclophosphamide. When amplifier cells were transferred to athymic nude (nu/nu) mice, the enhancement obtained was much greater than that produced in thymus-bearing (nu/+) mice; this is presumably due to the lack of suppressor T cell activity in nu/nu mice that enable amplifier T cell activity to be expressed more fully. Because amplifier T cells can be induced and activated by exposure to immune B cells, specificity is presumably due in whole or in part to the ability of amplifier T cells to recognize the idiotypic determinants of B cell-associated antibody specific for SSS-III. JF - Journal of Immunology AU - Taylor, CE AU - Stashak, P W AU - Chiang, J AU - Leiserson, WM AU - Caldes, G AU - Prescott, B AU - Baker, P J AD - LMI, NIAID, Natl. Inst. Health, Build. 5, Rm. 229, Bethesda, MD 20205, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 3103 EP - 3108 VL - 132 IS - 6 SN - 0022-1767, 0022-1767 KW - polysaccharides KW - mice KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Streptococcus pneumoniae KW - lymphocytes T KW - amplifier cells KW - capsules KW - antibody response KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13888714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Characteristics+of+amplifier+T+cells+involved+in+the+antibody+response+to+the+capsular+polysaccharide+of+type+III+Streptococcus+pneumoniae+.&rft.au=Taylor%2C+CE%3BStashak%2C+P+W%3BChiang%2C+J%3BLeiserson%2C+WM%3BCaldes%2C+G%3BPrescott%2C+B%3BBaker%2C+P+J&rft.aulast=Taylor&rft.aufirst=CE&rft.date=1984-01-01&rft.volume=132&rft.issue=6&rft.spage=3103&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; capsules; antibody response; lymphocytes T; amplifier cells ER - TY - JOUR T1 - Sequence of alcohol presentation is important in the potentiation of long-term events. AN - 13883474; 734737 AB - Animal and human studies have demonstrated that, depending upon the sequence of alcohol presentation, long-term memory of events can either be enhanced or diminished. In the present study a similar phenomenon is demonstrated in the neuronal excitability of slices of hippocampus from guinea pig brains. Alcohol given after, but not before, 3 days of pentylenetetrazol (PTZ) administration to the intact animal produced kindling equivalent to 5 days of PTZ given by itself. This effect appears to be independent of the known withdrawal effects of alcohol and lasts for at least 14 days after the alcohol and PTZ administration have been discontinued. JF - Psychopharmacology AU - Oliver AU - Parker, E S AU - Wyatt, R J AD - Adult Psychiatr. Branch, Div. Spec. Mental Health Res., Intramural Res. Program, NIMH, St. Elizabeths Hosp., Washington, DC 20205, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 52 EP - 54 VL - 82 IS - 1-2 SN - 0033-3158, 0033-3158 KW - effects on KW - alcohol KW - leptazol KW - guinea-pigs KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - kindling KW - long term memory KW - hippocampus KW - stimulants KW - X 24180:Social poisons & drug abuse KW - N3 11139:Toxicological and psychoactive drug correlates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13883474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Sequence+of+alcohol+presentation+is+important+in+the+potentiation+of+long-term+events.&rft.au=Oliver%3BParker%2C+E+S%3BWyatt%2C+R+J&rft.aulast=Oliver&rft.aufirst=&rft.date=1984-01-01&rft.volume=82&rft.issue=1-2&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - kindling; hippocampus; long term memory; stimulants ER - TY - JOUR T1 - Acetyl-blocked N-terminal structures of sorbitol and aldehyde dehydrogenases. AN - 13879900; 736182 AB - Two new dehydrogenase structures, the 354-residue polypeptide chain of sorbital dehydrogenase (from sheep liver) and the 500-residue polypeptide chain of cytoplasmic aldehyde dehydrogenase (from human liver), have blocked N-termini. The N-terminal peptides were purified by reverse-phase high-performance liquid chromatography and submitted to mass spectrometry after derivatization. They were also analyzed by dipeptidyl carboxypeptidase digestion, utilizing gas chromatography-mass spectrometry for dipeptide identifications. Results are consistent and establish that sorbitol dehydrogenase has N-terminal acetylalanine and aldehyde dehydrogenase N-terminal acetylserine in amino acid sequences that are compatible with estimates from chemical analyses. The two N-terminal residues found are typical of acetylated proteins in general, extend the group of known acetylated dehydrogenases, and show that these intracellular proteins are frequently N-terminally acetylated. JF - FEBS Letters AU - Fairwell, T AU - Krutzsch, H AU - Hempel, J AU - Jeffery, J AU - Joernvall, H AD - Mol. Dis. Branch, NHLBI, Lab. Exp. Carcinog., NCI, Bethesda, MD 20205, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 281 EP - 289 VL - 170 IS - 2 SN - 0014-5793, 0014-5793 KW - L-iditol dehydrogenase KW - N-terminus KW - acetylation KW - aldehyde dehydrogenase KW - amino acids KW - liver KW - man KW - sheep KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13879900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Acetyl-blocked+N-terminal+structures+of+sorbitol+and+aldehyde+dehydrogenases.&rft.au=Fairwell%2C+T%3BKrutzsch%2C+H%3BHempel%2C+J%3BJeffery%2C+J%3BJoernvall%2C+H&rft.aulast=Fairwell&rft.aufirst=T&rft.date=1984-01-01&rft.volume=170&rft.issue=2&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Comparison of the carcinogenic effectiveness of N-nitroso-bis(2-hydroxypropyl)amine, N-nitroso-bis(2-oxoproply)amine, N-nitroso-(2-hydroxyproply)-(2-oxopropyl)amine, and N-nitroso-2,6-dimethylmorpholine in Syrian hamsters. AN - 13873944; 718856 AB - For examination of metabolic interrelationships in carcinogenesis between N-nitroso-2,6-dimethylmorpholine, N-nitrosobis(2-oxopropyl)amine (CAS: 60599-38-4), N-nitrosobis(2-hydroxypropyl)amine (CAS: 53609-64-6), and N-nitroso(2-hydroxypropyl) (2-oxopropyl)amine, each was given to a separate group of 20 female Syrian golden hamsters by gavage. All four compounds induced tumors of the pancreatic duct and lung tumors, but the incidences varied from one compound to another. In addition, N-nitrosobis(2-oxopropyl)amine and N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine induced many hepatocellular and cholangiocellular neoplasms, which the other two compounds did not. JF - Journal of the National Cancer Institute AU - Lijinsky, W AU - Saavedra, JE AU - Knutsen, G L AU - Kovatch, R M AD - Chem. Carcinog. Program, NCI-Frederick Cancer Red. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 685 EP - 688 VL - 72 IS - 3 SN - 0027-8874, 0027-8874 KW - metabolism KW - hamsters KW - nitrosamines KW - N-nitroso-bis(2-hydroxypropyl)amine KW - N-nitroso-bis(2-oxopropyl)amine KW - N-nitroso-(2-hydroxypropyl)-(2-oxopropyl)amine KW - N-nitroso-2,6-dimethylmorpholine KW - Toxicology Abstracts KW - pancreas KW - lung KW - carcinogenicity KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13873944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Comparison+of+the+carcinogenic+effectiveness+of+N-nitroso-bis%282-hydroxypropyl%29amine%2C+N-nitroso-bis%282-oxoproply%29amine%2C+N-nitroso-%282-hydroxyproply%29-%282-oxopropyl%29amine%2C+and+N-nitroso-2%2C6-dimethylmorpholine+in+Syrian+hamsters.&rft.au=Lijinsky%2C+W%3BSaavedra%2C+JE%3BKnutsen%2C+G+L%3BKovatch%2C+R+M&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1984-01-01&rft.volume=72&rft.issue=3&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity; pancreas; lung ER - TY - JOUR T1 - A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats. AN - 13873175; 718892 AB - Methapyrilene hydrochloride (2-((2-(dimethylamino)ethyl)-2-thenylamino)pyridine monohydrochloride (CAS: 135-23-9))-induced hepatocarcinogenesis was studied in male F344/NCr rats by sequential histologic, histochemical, and biologic methods. Hepatocellular eosinophilic foci and adenomas were seen after 10 and 15 weeks, respectively. Basophilic foci and adenomas were found after 29 and 40 weeks, respectively. Hepatocellular carcinomas developed in 5 of 10 rats at week 40, in 3 of 5 rats at week 73, and in 19 of 19 rats that lived out their life-span. Carcinomas arose within adenomas or as small in situ carcinomas. The histologic types included trabecular, adenocarcinoma, mixed, and solid poorly differentiated hepatocellular carcinomas. Eleven of the mixed and solid poorly differentiated carcinomas metastasized to the lung. The findings suggest that multiple pathways may be followed in the development of methyapyrilene-induced liver cancer that are similar to those found in rats exposed to many other hepatic carcinogens. JF - Journal of the National Cancer Institute AU - Ohshima, M AU - Ward, J M AU - Brennan, L M AU - Creasia, DA AD - Build. 538, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 759 EP - 768 VL - 72 IS - 3 SN - 0027-8874, 0027-8874 KW - histopathology KW - rats KW - methapyrilene hydrochloride KW - Toxicology Abstracts KW - antihistamines KW - carcinogenesis KW - liver KW - X 24115:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13873175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=A+sequential+study+of+methapyrilene+hydrochloride-induced+liver+carcinogenesis+in+male+F344+rats.&rft.au=Ohshima%2C+M%3BWard%2C+J+M%3BBrennan%2C+L+M%3BCreasia%2C+DA&rft.aulast=Ohshima&rft.aufirst=M&rft.date=1984-01-01&rft.volume=72&rft.issue=3&rft.spage=759&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenesis; antihistamines; liver ER - TY - JOUR T1 - A rapid small-scale procedure for isolation of phage lambda DNA. AN - 13866625; 715225 AB - The authors describe here a rapid, technically easy procedure for the small-scale isolation of bacteriophage lambda DNA from liquid lysates. This procedure requires only a small volume of phage lysate, permits simultaneous processing of multiple samples, and requires less than 100 minutes from start to finish. It provides a rapid means to prepare sufficient lambda DNA for restriction analysis and cloning procedures. JF - Biotechniques AU - Benson, SA AU - Taylor, R K AD - LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 126 EP - 127 VL - 2 IS - 3 SN - 0736-6205, 0736-6205 KW - isolation KW - methodology KW - DNA KW - phage lambda KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - W 30114:Cloning vectors KW - N 14610:Occurrence, isolation & assay KW - V 22031:Viral nucleic acids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13866625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechniques&rft.atitle=A+rapid+small-scale+procedure+for+isolation+of+phage+lambda+DNA.&rft.au=Benson%2C+SA%3BTaylor%2C+R+K&rft.aulast=Benson&rft.aufirst=SA&rft.date=1984-01-01&rft.volume=2&rft.issue=3&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Biotechniques&rft.issn=07366205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - phage lambda; DNA ER - TY - JOUR T1 - Membrane ultrafiltration: Concentration of interleukin-3. AN - 13860944; 718066 AB - A pilot-plant-scale operation was used for studying membrane ultrafiltration and concentration of kiloliter quantities of the lymphokine interleukin-3 with a single set of membranes. Initial use of ammonium sulfate precipitation of interleukin-3 proved erratic in the recovery of biological activity and resulted in corrosion of the processing equipment. Membrane ultrafiltration proved to be effective in enabling control of the degree of concentration and predicting recovery of the biologically active protein. JF - Applied and Environmental Microbiology AU - Klein, F AU - Ricketts, R T AU - Rohrer, T R AU - Jones, WI Jr AU - Clark, P AU - Flickinger, M C AD - NCI-Frederick Cancer Res. Facil., Ferment. Program, Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 1023 EP - 1026 VL - 47 IS - 5 SN - 0099-2240, 0099-2240 KW - mammalian cells KW - purification KW - cell culture KW - interleukin 3 KW - membranes KW - ultrafiltration KW - Biotechnology and Bioengineering Abstracts KW - W 30404:Other peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13860944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Membrane+ultrafiltration%3A+Concentration+of+interleukin-3.&rft.au=Klein%2C+F%3BRicketts%2C+R+T%3BRohrer%2C+T+R%3BJones%2C+WI+Jr%3BClark%2C+P%3BFlickinger%2C+M+C&rft.aulast=Klein&rft.aufirst=F&rft.date=1984-01-01&rft.volume=47&rft.issue=5&rft.spage=1023&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Matrix effect in determination of 2,3,7,8-tetrachlorodibenzodioxin by mass spectrometry AN - 13860151; S198515581 AB - The determination of trace amounts of tetrachlorodibenzodioxin (TCDD) in liver tissue and goat milk using gas chromatography/mass spectrometry (GC/MS) was undertaken with respect to matrix effects. The matrix effects were examined using GC selected reaction monitoring (with low resolution of the primary ion beam) and GC selected ion monitoring (high resolution). A specific matrix was seen whilst using both techniques. The importance of monitoring simultaneously the response of the ion source with the measured event during the GC/MS experiment is emphasized. Recommendations are made that the bulk of the matrix should be removed before analysis. JF - Analytical Chemistry AU - Tondeur, Y AU - Albro, P W AU - Hass, J R AU - Harvan, D J AU - Schroeder, J L AD - National Institute of Environmental Health Sciences, North Carolina Y1 - 1984 PY - 1984 DA - 1984 SP - 1344 EP - 1347 VL - 56 IS - 8 KW - Tetrachlorodibenzo-p-dioxin KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13860151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Chemistry&rft.atitle=Matrix+effect+in+determination+of+2%2C3%2C7%2C8-tetrachlorodibenzodioxin+by+mass+spectrometry&rft.au=Tondeur%2C+Y%3BAlbro%2C+P+W%3BHass%2C+J+R%3BHarvan%2C+D+J%3BSchroeder%2C+J+L&rft.aulast=Tondeur&rft.aufirst=Y&rft.date=1984-01-01&rft.volume=56&rft.issue=8&rft.spage=1344&rft.isbn=&rft.btitle=&rft.title=Analytical+Chemistry&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Cloning vectors that yield high levels of single-stranded DNA for rapid DNA sequencing. AN - 13859220; 711762 AB - The authors have constructed chimeric plasmid vectors with the origin and intergenic region from M13 phage cloned into the PvuII (pZ145) and AhaIII (pZ150, pZ152) sites of pBR322. Upon infection with M13 phage, the viral origin present on the plasmids permits phage-directed plasmid replication and results in high yields of single-stranded (ss) plasmid DNA in M13-like particles. This ssDNA, which represents only one of the plasmid strands, is useful as a substrate for rapid DNA sequence determination. Since these plasmids contain an intact pBR322, the intergenic region can be transferred onto most pBR322 derivatives to yield ss plasmid DNA without affecting the recipient plasmid for further studies. The authors also constructed a deletion derivative of pZ145, plasmid pZ146, that does not exhibit interference with the growth of the M13 helper, although this plasmid is encapsidated into phage particles. This result confirms the theory that the intergenic region consists of two domains: one domain being a segment involved in phage morphogenesis and the other being a region of functional origin which interferes with M13 replication. JF - Gene AU - Zagursky, R J AU - Berman, M L AD - Lab. Genet. and Recom. DNA, LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 183 EP - 191 VL - 27 IS - 2 SN - 0378-1119, 0378-1119 KW - single stranded KW - plasmid pBR322 KW - production KW - DNA KW - cloning vectors KW - nucleotide sequence KW - phage M13 KW - plasmids KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - N 14682:Cloning vectors KW - W 30114:Cloning vectors KW - V 22050:Viral genetics including virus reactivation KW - J 02760:Plasmids KW - G 07120:Recombinant DNA/Genetic engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13859220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Cloning+vectors+that+yield+high+levels+of+single-stranded+DNA+for+rapid+DNA+sequencing.&rft.au=Zagursky%2C+R+J%3BBerman%2C+M+L&rft.aulast=Zagursky&rft.aufirst=R&rft.date=1984-01-01&rft.volume=27&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - phage M13; cloning vectors; DNA; nucleotide sequence; plasmids ER - TY - JOUR T1 - Sources of variability in Ames Salmonella typhimurium tester strains: Analysis of the International Collaborative Study on "Genetic Drift". AN - 13858145; 711943 AB - Data from 38 laboratories using 5 strains of Salmonella typhimurium (TA98, TA100, TA1535, TA1537, and TA1538) were analyzed to determine sources and magnitudes of test data variability. Each laboratory tested the mutagenicity of 4-nitroquinoline-N-oxide by the same protocol, using both its in-house cultures and a set of reference cultures provided to all laboratories. It was found that neither plate-to-plate nor day-to day variability within a laboratory differed substantially between the in-house and reference cultures for any strain; this indicated no difference in the laboratories' handling of the two cultures. On average, plate-to-plate variability was substantially smaller than day-to-day variability within a laboratory, which, in turn, was substantially smaller than inter-laboratory variability. The solvent DMSO was found to have a small (6-7%) but statistically significant depressive effect on the spontaneous mutant frequency for the two plasmid-containing strains. TA98 and TA100, but not for the other three strains. JF - Mutation Research AU - Margolin, B H AU - Risko, K J AU - Shelby, MD AU - Zeiger, E AD - Biometry and Risk Assess. Program, NIEHS, Research Triangle Park, NC 27709, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 11 EP - 25 VL - 130 IS - 1 SN - 0027-5107, 0027-5107 KW - strains KW - variability KW - analysis KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - genetic drift KW - Ames test KW - Salmonella typhimurium KW - G 07320:Bacterial genetics KW - A 01116:Bacteria KW - J 02710:Identification, taxonomy and typing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13858145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Sources+of+variability+in+Ames+Salmonella+typhimurium+tester+strains%3A+Analysis+of+the+International+Collaborative+Study+on+%22Genetic+Drift%22.&rft.au=Margolin%2C+B+H%3BRisko%2C+K+J%3BShelby%2C+MD%3BZeiger%2C+E&rft.aulast=Margolin&rft.aufirst=B&rft.date=1984-01-01&rft.volume=130&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Salmonella typhimurium; Ames test; genetic drift ER - TY - JOUR T1 - Mutagenesis and mutation transfer induced by ultraviolet light in plasmid-cloned DNA. AN - 13849578; 711592 AB - The authors describe a simple technique for increasing the frequency of UV-induced mutations in a DNA fragment cloned in plasmid pBR322. Irradiation of both the host and the plasmid DNA before transformation is necessary to produce new mutations in the plasmid DNA, presumably because the UV-damaged pBR322 replicon cannot efficiently induce the error-prone repair pathway of Escherichia coli . In contrast, UV irradiation of the plasmid DNA alone before transformation primarily causes the transfer of preexisting mutations from the host chromosome to homologous DNA present in the plasmid. The only other kind of mutants obtained were large deletions of the plasmid DNA. Two chromosomal mutations from the host galK gene and one from the lacZ gene have been transferred to the plasmid by UV irradiation of the plasmid DNA alone. The technique can thus be of general use. JF - Gene AU - Chattoraj, D K AU - Cordes, K AU - Berman, M L AU - Das, A AD - LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 213 EP - 222 VL - 27 IS - 2 SN - 0378-1119, 0378-1119 KW - plasmid pBR322 KW - induction KW - DNA KW - Escherichia coli KW - U.V. radiation KW - cloning KW - gene transfer KW - mutagenesis KW - plasmids KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - N 14630:Chemical reactions & interactions, including effects of radiation KW - J 02760:Plasmids KW - G 07120:Recombinant DNA/Genetic engineering KW - W 30119:Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13849578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Mutagenesis+and+mutation+transfer+induced+by+ultraviolet+light+in+plasmid-cloned+DNA.&rft.au=Chattoraj%2C+D+K%3BCordes%2C+K%3BBerman%2C+M+L%3BDas%2C+A&rft.aulast=Chattoraj&rft.aufirst=D&rft.date=1984-01-01&rft.volume=27&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; U.V. radiation; cloning; DNA; mutagenesis; gene transfer; plasmids ER - TY - JOUR T1 - Simplified estimation technique for organic contaminant transport in groundwater AN - 13847959; 198402399 AB - Previously derived models for solute transport in saturated soils were adapted to examine the interactions governing transport processes and thus aid the interpretation of field and laboratory data on hydrological environments being considered for underground disposal sites. The criteria for evaluating site suitability are derived and important transport variables identified for which values are required. JF - Journal of Hazardous Materials AU - Piver, W T AU - Lindstrom, F T AD - National Institute of Environmental Health Sciences, Research Triangle Park, N.C. Y1 - 1984 PY - 1984 DA - 1984 SP - 331 EP - 339 VL - 8 IS - 4 SN - 0304-3894, 0304-3894 KW - Aqualine Abstracts KW - AQ 00001:Water Resources and Supplies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13847959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=Simplified+estimation+technique+for+organic+contaminant+transport+in+groundwater&rft.au=Piver%2C+W+T%3BLindstrom%2C+F+T&rft.aulast=Piver&rft.aufirst=W&rft.date=1984-01-01&rft.volume=8&rft.issue=4&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Theoretical. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Complete amino acid sequence of the basic nucleic acid binding protein of feline leukemia virus. AN - 13845433; 698012 AB - The complete amino acid sequence of the nucleic acid binding protein p10 of the Rickard strain of feline leukemia virus (FeLV) has been determined. Fragments obtained by enzymatic digestion were purified by reverse-phase liquid chromatography and subjected to semiautomated Edman degradation. FeLV p10 is a basic polypeptide composed of 57 amino acids with M sub(r) = 6604. The structure of p10 is compared to the structures of other retroviral nucleic acid binding proteins, and an analysis of a highly conserved region, the putative binding domain, is presented. JF - Virology AU - Copeland, T D AU - Morgan, MA AU - Oroszlan, S AD - Lab. Mol. Virol. and Carcinogenesis, LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 137 EP - 145 VL - 133 IS - 1 SN - 0042-6822, 0042-6822 KW - Edman degradation KW - Feline leukemic virus KW - amino acid sequence KW - nucleic acid-binding protein KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - N 14930:Transcription factors KW - V 22032:Viral proteins KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13845433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Complete+amino+acid+sequence+of+the+basic+nucleic+acid+binding+protein+of+feline+leukemia+virus.&rft.au=Copeland%2C+T+D%3BMorgan%2C+MA%3BOroszlan%2C+S&rft.aulast=Copeland&rft.aufirst=T&rft.date=1984-01-01&rft.volume=133&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - amino acid sequence; Edman degradation ER - TY - JOUR T1 - Variation of hepatic aryl hydrocarbon hydroxylase (AHH) and 7-ethoxyresorufin 0-deethylase (7-ERD) activities in marine fish from Maine: evidence that monooxygenase activities of only a few species are induced by environmental exposure to polycyclic aromatic hydrocarbon (PAH) - type compounds AN - 13842354; S198515014 AB - Nine species of marine invertebrates: winter flounder (Pseudopleuronectes americanus), Fundulus heteroclitus, mackerel (Scomber scombrus), little skate (Raja erinacea), eel (Anguilla rostrata), longhorn sculpin (Myoxocephalus octodecimspinosus), hagfish (Myxine glutinosa), sea raven (Hemitripterus americanus), and dogfish shark (Squalus acanthius) were sampled from marine habitats in Maine. Hepatic aryl hydrocarbon hydroxylase (AHH) and 7-ethoxyresorufin 0-deethylase (7-ERD) activities were measured to determine if individual members of these species had hepatic cytochrome P-450-dependent monooxygenase systems that were induced by exposure to polycyclic aromatic hydrocarbon (PAH)-type compounds. Only winter flounder and F. heteroclitus showed significant evidence of such systems indicating that this phenomenon was species- selective. JF - Marine Environmental Research AU - Bend, J R AU - Foureman, CL AD - National Institute of Environmental Health Sciences, N.C. Y1 - 1984 PY - 1984 DA - 1984 SP - 405 EP - 406 VL - 14 IS - 1/4 SN - 0141-1136, 0141-1136 KW - Jn - marine environ. res. KW - Aqualine Abstracts KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13842354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Environmental+Research&rft.atitle=Variation+of+hepatic+aryl+hydrocarbon+hydroxylase+%28AHH%29+and+7-ethoxyresorufin+0-deethylase+%287-ERD%29+activities+in+marine+fish+from+Maine%3A+evidence+that+monooxygenase+activities+of+only+a+few+species+are+induced+by+environmental+exposure+to+polycyclic+aromatic+hydrocarbon+%28PAH%29+-+type+compounds&rft.au=Bend%2C+J+R%3BFoureman%2C+CL&rft.aulast=Bend&rft.aufirst=J&rft.date=1984-01-01&rft.volume=14&rft.issue=1%2F4&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Marine+Environmental+Research&rft.issn=01411136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Characteristics of an extraction and purification procedure for chlorinated dibenzo-p-dioxins and dibenzofurans in soil and liver AN - 13837409; S198517009 AB - New procedures have been developed for extraction and cleanup procedures for chlorinated dibenzo-dioxin and furans (CDD and CDF) in soil and liver matrices, with high and reproducible recoveries and with a relatively rapid elimination of interferences to permit reliable determination by GC-MS at below ppb levels. Liver samples were extracted quantitatively with chloroform/methanol and most of the lipids were removed on LH-20 Sephadex. Soil samples were extracted successively through a glass wool/sodium sulphate 'sandwich' by ethyl acetate and methylene chloride. Preparation was completed by clean-up on basic and acidic alumina. The use of propylene glycol as a 'keeper' and of 2,3,7-trichlorodibenzo-p- dioxin as a carrier minimized evaporation losses. High recoveries were obtained at the 450 ppt level, but selective losses of some CDD and CDF isomers and some interference from PCB were disadvantages. A bibliography of 63 references is appended. JF - Journal of Chromatography AU - Albro, P W AU - Schroeder, J S AU - Harvan, D J AU - Corbett, B J AD - National Institute of Environmental Health Sciences, Research Triangle Park, N.C. Y1 - 1984 PY - 1984 DA - 1984 SP - 165 EP - 182 VL - 312 SN - 0021-9673, 0021-9673 KW - Sephadex KW - Ethylacetate KW - Methylene chloride KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13837409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography&rft.atitle=Characteristics+of+an+extraction+and+purification+procedure+for+chlorinated+dibenzo-p-dioxins+and+dibenzofurans+in+soil+and+liver&rft.au=Albro%2C+P+W%3BSchroeder%2C+J+S%3BHarvan%2C+D+J%3BCorbett%2C+B+J&rft.aulast=Albro&rft.aufirst=P&rft.date=1984-01-01&rft.volume=312&rft.issue=&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography&rft.issn=00219673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Effect of di(2-ethylhexyl) phthalate on DNA repair and lipid peroxidation in rat hepatocytes and on metabolic cooperation in Chinese hamster V-79 cells. AN - 13833388; 694345 AB - Experiments were conducted to test the hypothesis that the hepatocarcinogenicity of di(2-ethylhexyl) phthalate (DEHP) is due to its ability to produce DNA damage, either directly or as a result of the proliferation of peroxisomes and accompanying increased production of H sub(2)O sub(2) and other DNA-damaging oxygen radicals induced by sustained exposure to the plasticizer. DNA repair, as assessed by the autoradiographic measurement of unscheduled DNA synthesis (UDS), was not observed in primary rat hepatocytes exposed in vitro to 10 super(-5)-10 super(-2) M DEHP or in vivo by a single gavage dose of 5 g DEHP/kg body weight administered 2, 15, or 24 h prior to the isolation of heptocytes. Thus, DEHP does not appear to directly reduce repairable DNA damage in rat hepatocytes. These findings suggest that DEHP does not elicit DNA damage or lipid peroxidation in liver consequent to the proliferation of peroxisomes resulting from prolonged administration. In addition, at noncytotoxic concentrations DEHP failed to produce a positive response in the Chinese hamster V-79 metabolic cooperation assay for tumor promoters. JF - Journal of Toxicology and Environmental Health AU - Kornbrust, D J AU - Barfknecht, T R AU - Ingram, P AU - Shelbourne, J D AD - NIEHS, P.O. Box 12233, MDE2-01, Research Trangle Park, NC 27709, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 99 EP - 116 VL - 13 IS - 1 SN - 0093-4108, 0093-4108 KW - effects on KW - hepatocytes KW - hamsters KW - DNA repair KW - lipid peroxidation KW - di-(2-ethylhexyl)phthalate KW - rats KW - Pollution Abstracts; Health & Safety Science Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts; Genetics Abstracts KW - animals KW - metabolism KW - toxicology KW - genetics KW - X 24155:Biochemistry KW - N 14652:DNA repair KW - H SM5.1:BASIC APPROACHES, CONCEPTS, AND THEORY KW - P 6000:TOXICOLOGY AND HEALTH KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13833388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=Effect+of+di%282-ethylhexyl%29+phthalate+on+DNA+repair+and+lipid+peroxidation+in+rat+hepatocytes+and+on+metabolic+cooperation+in+Chinese+hamster+V-79+cells.&rft.au=Kornbrust%2C+D+J%3BBarfknecht%2C+T+R%3BIngram%2C+P%3BShelbourne%2C+J+D&rft.aulast=Kornbrust&rft.aufirst=D&rft.date=1984-01-01&rft.volume=13&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - rats; metabolism; genetics; toxicology; animals; hepatocytes; DNA repair; lipid peroxidation ER - TY - JOUR T1 - Lectin-induced modulation of the antibody response to type III pneucoccal polysaccharide. AN - 13800324; 656697 AB - Several lectins were tested for their capacity to alter the antibody response to type III pneumococcal polysaccharide (SSS-III). The antibody response was enhanced by concanavalin A (Con A), phytohemagglutinin (PHA), as well as lectins from Phytolacca americana (Pa-2), Pisum sativum (PSA), and Lens culinaris (LCH), when these lectins were given 2 days after immunization with SSS-III; however, suppression was obtained when Con A and Pa-2 were given at the time of immunization. By contrast the lectins from Vicia villosa (VVL) and Bauhinia purpurea (BPA) did not alter the antibody response. These findings indicate that there is no relationship between nominal monosaccharide specificity and the capacity to modulate the antibody response. Substantial increases in the magnitude of the IgG sub(1) antibody response was noted after the administration of Con A whereas profound enhancement of IgG sub(2a) antibody response was noted after PHA was given. JF - Cellular Immunology AU - Taylor, CE AU - Stashak, P W AU - Caldes, G AU - Prescott, B AU - Fowlkes, B J AU - Baker, P J AD - LMI, NIAID, NIH, Build. 5, Rm. 229, Bethesda, MD 20205, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 26 EP - 33 VL - 83 IS - 1 SN - 0008-8749, 0008-8749 KW - role KW - antibody response KW - association KW - lectins KW - Polysaccharides KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Lens culinaris KW - animal models KW - Pisum sativum KW - Streptococcus pneumoniae KW - Phytolacca americana KW - immunomodulation KW - F 06789:Experimental KW - F 06801:Bacteria KW - F 06791:Experimental KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13800324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Immunology&rft.atitle=Lectin-induced+modulation+of+the+antibody+response+to+type+III+pneucoccal+polysaccharide.&rft.au=Taylor%2C+CE%3BStashak%2C+P+W%3BCaldes%2C+G%3BPrescott%2C+B%3BFowlkes%2C+B+J%3BBaker%2C+P+J&rft.aulast=Taylor&rft.aufirst=CE&rft.date=1984-01-01&rft.volume=83&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Cellular+Immunology&rft.issn=00088749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; Phytolacca americana; Pisum sativum; Lens culinaris; immunomodulation; animal models ER - TY - JOUR T1 - Carcinogenesis in rats by some hydroxylated acyclic nitrosamines. AN - 13792247; 647920 AB - A comparison was made of the carcinogenic effectiveness of five hydroxylated nitrosodialkylamines given to female F344 rats in drinking water. Nitroso-2,3-dihydroxypropyl-2-hydroxypropylamine was the most potent carcinogen among those examined, and induced almost exclusively tumors of the upper gastrointestinal tract. Considerably less potent was nitrosobis-(2-hydroxypropyl)amine, which also induced mainly tumors of the esophagus. Nitrosodiethanolamine was weaker again, and induced a high incidence of hepatocellular carcinomas. Nitroso-2-hydroxypropylethanolamine, which can be considered a hybrid of nitrosodiethanolamine and the bis-hydroxypropyl compound, induced both esophageal tumors and hepatocellular carcinomas, together with some liver angiosarcomas; it appeared to lie in potency between the two symmetrical compounds. In contrast, nitroso-2,3-dihydroxypropylethanolamine was a very weak carcinogen, having little life-shortening effect. JF - Carcinogenesis AU - Lijinsky, W AU - Saavedra, JE AU - Reuber, MD AD - LBI-Basic Res. Program, Chem. Carcinogenesis Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 167 EP - 170 VL - 5 IS - 2 SN - 0143-3334, 0143-3334 KW - nitrosamines KW - rats KW - Toxicology Abstracts KW - carcinogenicity KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13792247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Carcinogenesis+in+rats+by+some+hydroxylated+acyclic+nitrosamines.&rft.au=Lijinsky%2C+W%3BSaavedra%2C+JE%3BReuber%2C+MD&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1984-01-01&rft.volume=5&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity ER - TY - JOUR T1 - Persistence of benzo(a)pyrene metabolite:DNA adducts in lung and liver of mice. AN - 13790592; 647580 AB - The persistence of benzo(a)pyrene (BP) metabolite:DNA adducts has been studied in lung and liver of A/HeJ and C57BL/6J mice after a dose of BP (6 mg/mouse) which induces pulmonary adenomas in A/HeJ mice but not in C57BL/6J mice. BP is not a hepatic carcinogen in either strain. The results suggest that the tissue specificity for BP-induced neoplasia in A/HeJ mice may be related to the relative persistence of adducts and high cell turnover rates in lung. The results on formation and persistence of adducts and cell turnover do not provide an explanation for the strain difference in susceptibility to BP-induced pulmonary adenomas. JF - Cancer Research AU - Kulkarni AU - Anderson, M W AD - Lab. Pharmacol., NIEHS/NIH, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1984 PY - 1984 DA - 1984 SP - 97 EP - 101 VL - 44 IS - 1 SN - 0008-5472, 0008-5472 KW - metabolites KW - adducts KW - persistence KW - role KW - benzo(a)pyrene KW - mice KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - lung KW - tumorigenesis KW - DNA KW - liver KW - N 14630:Chemical reactions & interactions, including effects of radiation KW - X 24190:Polycyclic hydrocarbons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13790592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Persistence+of+benzo%28a%29pyrene+metabolite%3ADNA+adducts+in+lung+and+liver+of+mice.&rft.au=Kulkarni%3BAnderson%2C+M+W&rft.aulast=Kulkarni&rft.aufirst=&rft.date=1984-01-01&rft.volume=44&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - DNA; tumorigenesis; lung; liver ER - TY - JOUR T1 - Intensive combined modality therapy including low-dose TBI in high-risk Ewing's Sarcoma Patients. AN - 80978844; 9463099 AB - Twenty-four high-risk Ewing's sarcoma patients were treatedf on an intensive combined modality protocol including low-dose fractionated total body irradiation (TBI) and autologous bone marrow infusion (ABMI). Twenty patients (83%) achieved a complete clinical response to the primary and/or metastatic sites following induction therapy. The median disease-free interval was 18 months, and nine patients remain disease-free with a follow-up of 22 to 72 months. Local failure as a manifestation of initial relapse occurred in only three patients (15%), each having synchronous distant failure. Eight patients failed initially with only distant metastases, usually within 1-2 years following a complete clinical response. Two patients with a single metastasis were again rendered disease-free and remain free from second relapse with 18 and 30 months follow-up. No other relapsed patient was able to be rendered disease-free, and most died of progressive disease within 6 to 12 months of relapse. Two patterns of granulocyte recovery following consolidative therapy (include TBI) and ABMI were recognized. Seventeen patients reached a total granulocyte count of >500 cells/mm3 within 4 weeks of ABMI (early graulocyte recovery), while seven patients required >4 weeks from ABMI (late granulocyte recovery). The time of platelet recovery (>50,000/mm3) was different for the groups with early and late granulocyte recovery (25 days vs. 54 days, p 1/2 pelvis prior to bone marrow storage. Patients with late recovery did not tolerate maintenance chemotherapy. However, there was no difference in disease-free and overall survival, when compaing the groups with early and late granulocyte recovery. We conclude that these high-risk Ewing's sarcoma patients remain a poor-prognosis group in spite of intensive combined modality therapy include low-dose TBI. The control of microscopic systemic disease remains the major challenge to improving the cure rate. A new combined modality protocol with high-dose 'therapeutic' TBI (800 rad/2 fractions) is being used and the protocol design is outlined. JF - International journal of radiation oncology, biology, physics AU - Kinsella, T J AU - Glaubiger, D AU - Diesseroth, A AU - Makuch, R AU - Waller, B AU - Pizzo, P AU - Glatstein, E AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 1983/12// PY - 1983 DA - December 1983 SP - 1955 EP - 1960 VL - 9 IS - 12 SN - 0360-3016, 0360-3016 KW - Dactinomycin KW - 1CC1JFE158 KW - Vincristine KW - 5J49Q6B70F KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Disease-Free Survival KW - Combined Modality Therapy KW - Humans KW - Lung Neoplasms -- secondary KW - Vincristine -- administration & dosage KW - Lung Neoplasms -- therapy KW - Child KW - Adult KW - Neoplasm Recurrence, Local KW - Adolescent KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Male KW - Female KW - Agranulocytosis -- therapy KW - Dactinomycin -- administration & dosage KW - Sarcoma, Ewing -- pathology KW - Whole-Body Irradiation KW - Sarcoma, Ewing -- secondary KW - Bone Neoplasms -- pathology KW - Bone Neoplasms -- therapy KW - Sarcoma, Ewing -- therapy KW - Bone Marrow Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80978844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Intensive+combined+modality+therapy+including+low-dose+TBI+in+high-risk+Ewing%27s+Sarcoma+Patients.&rft.au=Kinsella%2C+T+J%3BGlaubiger%2C+D%3BDiesseroth%2C+A%3BMakuch%2C+R%3BWaller%2C+B%3BPizzo%2C+P%3BGlatstein%2C+E&rft.aulast=Kinsella&rft.aufirst=T&rft.date=1983-12-01&rft.volume=9&rft.issue=12&rft.spage=1955&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-02-12 N1 - Date created - 1998-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism of the production of the negative endocochlear DC potential in the guinea pig. AN - 85194503; pmid-6415593 AB - Changes in endocochlear DC potential (EP) and potassium ion concentrations in endolymph were measured simultaneously during anoxia or during perfusion of the perilymphatic space with furosemide, 10(-2)M, in normal and kanamycin-deafened guinea pigs. The potassium ion conductance (Gk) through the cochlear partitions was calculated. Thirty minutes after the onset of anoxia, the Gk is 22.1 microM/min/mV in normal guinea pigs and 4.8 microM/min/mV in kanamycin-deafened guinea pigs. At that time the EP is -29.5 mV in normal guinea pigs and 1.4 mV in kanamycin-deafened guinea pigs. In the early stage of anoxia the rate of potassium ion concentration decrease in the endolymph per unit time is greater in normal guinea pigs than in kanamycin-deafened guinea pigs. These results suggest a rapid increase in the permeability of potassium ions in the organ of Corti in the early stage of anoxia might produce a large negative potassium ion diffusion potential or negative EP in normal guinea pigs and the failure to develop the negative EP in kanamycin-deafened guinea pigs might be due to the lack of such a rapid increase in the permeability because of the loss of the hair cells. JF - Otolaryngology--Head and Neck Surgery AU - Komune, S AU - Huangfu, M AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1983 SP - 427 EP - 434 VL - 91 IS - 4 SN - 0194-5998, 0194-5998 KW - Cochlea KW - Deafness KW - Endolymph KW - Guinea Pigs KW - Animal KW - Potassium KW - Kanamycin KW - Anoxia KW - Mathematics KW - Evoked Potentials, Auditory KW - Cochlear Microphonic Potentials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85194503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Mechanism+of+the+production+of+the+negative+endocochlear+DC+potential+in+the+guinea+pig.&rft.au=Komune%2C+S%3BHuangfu%2C+M%3BSnow%2C+J+B&rft.aulast=Komune&rft.aufirst=S&rft.date=1983-08-01&rft.volume=91&rft.issue=4&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Clinical problems in chemosensory disturbances. AN - 85206963; pmid-6625101 AB - The clinical evaluation of patients with disorders of smell and taste has been hampered by difficulties in stimulus control and response measurement. These senses play a crucial role in food selection and enjoyment and in avoidance of danger, and they deserve the attention of the otolaryngologist as much as audition and vestibular function do. The definition of the degree of disability should be based on psychophysical measures rather than the patient's complaint. An anatomic diagnosis may facilitate the etiologic diagnosis, and it is important to attempt to differentiate transport abnormalities from sensorineural deficits, and receptor deficits from neural deficits. The common causes of smell and taste abnormalities are listed. Selected current work in the field with immediate clinical relevance is reviewed, and opportunities for basic studies that may provide needed data to improve the diagnostic evaluation of patients and to suggest therapeutic strategies for clinical trials are briefly discussed. These areas of study can be pursued with currently available technology. JF - American Journal of Otolaryngology AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1983 SP - 224 EP - 227 VL - 4 IS - 4 SN - 0196-0709, 0196-0709 KW - Taste Disorders KW - Chemoreceptors KW - Olfaction Disorders KW - Food Preferences KW - Human KW - Nervous System Diseases KW - Sensation KW - Smell UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85206963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Otolaryngology&rft.atitle=Clinical+problems+in+chemosensory+disturbances.&rft.au=Snow%2C+J+B&rft.aulast=Snow&rft.aufirst=J&rft.date=1983-07-01&rft.volume=4&rft.issue=4&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Otolaryngology&rft.issn=01960709&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Training for Responsible Professional Behavior in Psychology and Social Work AN - 61583859; 198501681 AB - The relationship between competence, accountability, & ethical professional behavior in psychology & social work is explored, with particular attention to the attempts of graduate training programs to prepare students for ethical professional conduct. Findings from a mailed questionnaire survey that obtained responses from 31 of 85 approved graduate programs in social work & 54 of 117 approved programs in psychology are presented. Several specific proposals are offered to the two professions' accrediting bodies. In A Response to: Training for Responsible Professional Behavior in Psychology and Social Work Ethics, Samoan Barish (2006 Skyview Dr, Altadena, Calif) calls for more in-depth study of individual programs, & examines the experience of the Calif Instit for Clinical Social Work. In A Response to: Training for Responsible Professional Behavior in Psychology and Social Work, Zofia Butrym (London School of Economics, England) briefly reviews the situation in GB & finds it strongly comparable to that in the US described by Pharis & Hill. In particular, too much attention is given by social workers to material needs & too little to human values & self-reliance. 2 References. W. H. Stoddard. JF - Clinical Social Work Journal AU - Pharis, Mary E AU - Hill, Karen R AD - Mental Health Center NIMH, 2340 University Blvd East Adelphi MD 20783 Y1 - 1983/07// PY - 1983 DA - July 1983 SP - 178 EP - 183 VL - 11 IS - 2 SN - 0091-1674, 0091-1674 KW - psychology/social work graduate training programs, ethical conduct preparation KW - questionnaire survey KW - approved graduate programs KW - replies KW - Graduate/Graduates/Graduation KW - Social work KW - Ethic/Ethics/Ethical KW - Education/Educational/Educator/ Educators/ Educationally KW - Psychology/Psychological/ Psychologically/ Psychologism KW - article KW - 6150: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61583859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Social+Work+Journal&rft.atitle=Training+for+Responsible+Professional+Behavior+in+Psychology+and+Social+Work&rft.au=Pharis%2C+Mary+E%3BHill%2C+Karen+R&rft.aulast=Pharis&rft.aufirst=Mary&rft.date=1983-07-01&rft.volume=11&rft.issue=2&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Clinical+Social+Work+Journal&rft.issn=00911674&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - SuppNotes - Replies, 184-190. N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Psychology/Psychological/ Psychologically/ Psychologism; Social work; Graduate/Graduates/Graduation; Education/Educational/Educator/ Educators/ Educationally; Ethic/Ethics/Ethical ER - TY - JOUR T1 - Effects of subcertification on residency training. Otolaryngology--head and neck surgery. AN - 85194535; pmid-6410317 JF - Otolaryngology--Head and Neck Surgery AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1983 SP - 225 EP - 226 VL - 91 IS - 3 SN - 0194-5998, 0194-5998 KW - United States KW - Specialty Boards KW - Head KW - Human KW - Surgery KW - Internship and Residency KW - Certification KW - Neck KW - Otolaryngology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85194535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Effects+of+subcertification+on+residency+training.+Otolaryngology--head+and+neck+surgery.&rft.au=Snow%2C+J+B&rft.aulast=Snow&rft.aufirst=J&rft.date=1983-06-01&rft.volume=91&rft.issue=3&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The Effects of Nerve Growth Factor on Poly amine Metabolism in PC12 Cells AN - 879470075; 14304210 AB - Abstract: Nerve growth factor treatment produces a large increase in the activity of ornithine decarboxylase and a moderate decrease in the activity of S-adenosylmethionine decarboxylase in PC12 cells. These changes are reflected weakly, if at all, in the levels of putrescine, spermidine, and spermine in the cells. The rates of polyamine synthesis are increased somewhat more than the overall levels, but still are not comparable in extent to the increase in the ornithine decarboxylase activity. Inhibitors of ornithine decarboxylase and S-adenosylmethionine decarboxylase have their expected effects on the induction of ornithine decarboxylase and on the activities of both enzymes. Neither inhibitor alone, nor a combination of inhibitors, altered the rate or extent of nerve growth factor-induced neurite outgrowth in the cells. JF - Journal of Neurochemistry AU - Guroff, Gordon AU - Dickens, Geneva AD - Section on Intermediary Metabolism, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, U.S.A. Y1 - 1983/05// PY - 1983 DA - May 1983 SP - 1271 EP - 1277 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 40 IS - 5 SN - 0022-3042, 0022-3042 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Axonogenesis KW - Enzymes KW - Metabolism KW - Nerve growth factor KW - Nerves KW - Ornithine decarboxylase KW - Pheochromocytoma cells KW - Putrescine KW - S-Adenosylmethionine KW - Spermidine KW - Spermine KW - amines KW - polyamines KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879470075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=The+Effects+of+Nerve+Growth+Factor+on+Poly+amine+Metabolism+in+PC12+Cells&rft.au=Guroff%2C+Gordon%3BDickens%2C+Geneva&rft.aulast=Guroff&rft.aufirst=Gordon&rft.date=1983-05-01&rft.volume=40&rft.issue=5&rft.spage=1271&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/10.1111%2Fj.1471-4159.1983.tb13566.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Document feature - figure 1 N1 - Last updated - 2012-10-08 N1 - SubjectsTermNotLitGenreText - Nerve growth factor; Spermine; Ornithine decarboxylase; Enzymes; Nerves; amines; Pheochromocytoma cells; Putrescine; Spermidine; polyamines; Axonogenesis; S-Adenosylmethionine; Metabolism DO - http://dx.doi.org/10.1111/j.1471-4159.1983.tb13566.x ER - TY - JOUR T1 - Mechanism of Inhibition of Jack Bean alpha-Mannosidase by Swainsonine. AN - 733488440; 16662865 AB - The indolizidine alkaloid, swainsonine, was previously shown to be a potent inhibitor of lysosomal and jack bean alpha-mannosidase (Dorling, Huxtable, Colegate 1980 Biochem J 191: 649-651). We examined the effects of various concentrations of this alkaloid on a number of commercially available glycosidases and found swainsonine to be quite specific for alpha-mannosidase (50% inhibition at 1-5 x 10(-7) molar). Optimum inhibition was observed after a 2-minute preincubation of enzyme and inhibitor. Lineweaver-Burk plots of substrate concentration versus velocity in the presence of various amounts of swainsonine showed considerable curvature at high substrate concentrations, suggesting that swainsonine may be a competitive inhibitor that binds tightly to the enzyme and is only slowly removed. Periodate oxidation of swainsonine completely destroyed its inhibitory activity. JF - Plant physiology AU - Kang, M S AU - Elbein, A D AD - Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland 21701. Y1 - 1983/03// PY - 1983 DA - March 1983 SP - 551 EP - 554 VL - 71 IS - 3 SN - 0032-0889, 0032-0889 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733488440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plant+physiology&rft.atitle=Mechanism+of+Inhibition+of+Jack+Bean+alpha-Mannosidase+by+Swainsonine.&rft.au=Kang%2C+M+S%3BElbein%2C+A+D&rft.aulast=Kang&rft.aufirst=M&rft.date=1983-03-01&rft.volume=71&rft.issue=3&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Plant+physiology&rft.issn=00320889&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-29 N1 - Date created - 2010-06-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1982 Feb 25;257(4):1573-6 [6799507] J Biol Chem. 1982 Jul 25;257(14):7936-9 [6806288] Science. 1982 Apr 9;216(4542):190-1 [6801763] Proc Natl Acad Sci U S A. 1981 Dec;78(12):7393-7 [6801650] Biochem J. 1980 Nov 1;191(2):649-51 [6786280] Virology. 1978 May 15;86(2):432-42 [664240] Neuropathol Appl Neurobiol. 1978 Jul-Aug;4(4):285-95 [703929] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Basic characteristics of permafrost in Northeast China AN - 51506031; 1984-038357 AB - There are two kinds of permafrost in Northeast China: high-latitude permafrost and alpine (high-altitude) permafrost. The high-latitude permafrost is distributed mainly in the Da-Xiao Hinggan Liq and occupies an area of about 38,000 km (super 2) , while the alpine permafrost is only sporadic. From south to north in Northeast China, the mean annual air temperature drops from 0 degrees -1 degrees C and down to -5 degrees or -6 degrees C, and the landscape changes from forest-steppe, through mixed coniferous and broad-leaf forest, to coniferous forest, and the permafrost varies correspondingly in continuity, temperature, and thickness. In the south, there is insular permafrost, 5-10 m thick, with a mean annual ground temperature of 0 degrees C. In the north, the large-patch continuous permafrost has a mean annual ground temperature of 0 degrees to -2.5 degrees C (and in some places even lower than -4.2 degrees C) and is 80-100 m thick. Between these two extremes there is a transitional permafrost zone with insular taliks. The southern limit of permafrost descended to the upper course of the Liao He River during the last glacial period. The existing permafrost is the sum of relic permafrost formed in the late Pleistocene and younger permafrost formed in the last 3000 years.--Journal abstract. JF - International Conference on Permafrost, Proceedings AU - Lu, Guowei AU - Guo, Dongxin AU - Dai, Jingbo AU - Pewe, Troy L AU - Brown, Jerry Y1 - 1983 PY - 1983 DA - 1983 SP - 740 EP - 743 PB - [publisher varies], [location varies] VL - 4 KW - Da-Xiao Hinggan Ling KW - terrestrial environment KW - permafrost KW - Far East KW - Northwestern China KW - Xinjiang China KW - landforms KW - periglacial features KW - vegetation KW - Cenozoic KW - Aohanqui KW - Asia KW - taliks KW - China KW - alpine environment KW - Quaternary KW - Changtu KW - Pleistocene KW - glacial geology KW - geomorphology KW - landscapes KW - Liao He River KW - frozen ground KW - changes KW - 24:Quaternary geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51506031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Conference+on+Permafrost%2C+Proceedings&rft.atitle=Basic+characteristics+of+permafrost+in+Northeast+China&rft.au=Lu%2C+Guowei%3BGuo%2C+Dongxin%3BDai%2C+Jingbo%3BPewe%2C+Troy+L%3BBrown%2C+Jerry&rft.aulast=Lu&rft.aufirst=Guowei&rft.date=1983-01-01&rft.volume=4&rft.issue=&rft.spage=740&rft.isbn=0309034353&rft.btitle=&rft.title=International+Conference+on+Permafrost%2C+Proceedings&rft.issn=&rft_id=info:doi/ L2 - http://ipa.arcticportal.org/meetings/international-conferences.html LA - English DB - GeoRef N1 - Conference title - Permafrost; Fourth international conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1984-01-01 N1 - Number of references - 4 N1 - Document feature - sketch map N1 - Last updated - 2012-06-06 N1 - CODEN - #00164 N1 - SubjectsTermNotLitGenreText - alpine environment; Aohanqui; Asia; Cenozoic; changes; Changtu; China; Da-Xiao Hinggan Ling; Far East; frozen ground; geomorphology; glacial geology; landforms; landscapes; Liao He River; Northwestern China; periglacial features; permafrost; Pleistocene; Quaternary; taliks; terrestrial environment; vegetation; Xinjiang China ER - TY - JOUR T1 - On Pseudogymnosolenidae of late Precambrian in China AN - 51293977; 1986-008439 JF - Bulletin of the Chinese Academy of Geological Sciences AU - Liang, Yuzuo AU - Cao, Ruiji AU - Zhang, Luyi AU - Qiu, Shuyu AU - Xiao, Zhongzheng AU - Du, Rulin AU - Cao, Renguan AU - Bu De, An AU - Zhu, Shixing AU - Gao, Zhenjia Y1 - 1983 PY - 1983 DA - 1983 SP - 125 EP - 130 PB - Chinese Academy of Geological Sciences, Beijing VL - 6 SN - 0254-3176, 0254-3176 KW - stratigraphy KW - Plantae KW - Far East KW - upper Precambrian KW - Precambrian KW - biostratigraphy KW - biogenic structures KW - correlation KW - algae KW - stromatolites KW - Pseudogymnosolenidae KW - Jixian China KW - Hebei China KW - Asia KW - sedimentary structures KW - microfossils KW - China KW - 12:Stratigraphy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51293977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+the+Chinese+Academy+of+Geological+Sciences&rft.atitle=On+Pseudogymnosolenidae+of+late+Precambrian+in+China&rft.au=Liang%2C+Yuzuo%3BCao%2C+Ruiji%3BZhang%2C+Luyi%3BQiu%2C+Shuyu%3BXiao%2C+Zhongzheng%3BDu%2C+Rulin%3BCao%2C+Renguan%3BBu+De%2C+An%3BZhu%2C+Shixing%3BGao%2C+Zhenjia&rft.aulast=Liang&rft.aufirst=Yuzuo&rft.date=1983-01-01&rft.volume=6&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+the+Chinese+Academy+of+Geological+Sciences&rft.issn=02543176&rft_id=info:doi/ LA - Chinese DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from PASCAL, Institute de l'Information Scientifique et Technique, Vandoeuvre-les-Nancy, France N1 - Date revised - 1986-01-01 N1 - Document feature - illus. incl. strat. cols., table, plates N1 - Last updated - 2012-06-06 N1 - SubjectsTermNotLitGenreText - algae; Asia; biogenic structures; biostratigraphy; China; correlation; Far East; Hebei China; Jixian China; microfossils; Plantae; Precambrian; Pseudogymnosolenidae; sedimentary structures; stratigraphy; stromatolites; upper Precambrian ER - TY - JOUR T1 - The Demography of Refugees AN - 20076374; 10123450 AB - This article focuses on the numbers of refugees in the world by major areas. It gives some background on refugee movements and characteristics in order to suggest parameters of future movements, and especially of those that may have implications for the United States with respect to (1) assistance programs in situ or (2) acceptance of refugees into the United States. JF - Annals of the American Academy of Political and Social Science AU - Huyck, Earl E AU - Bouvier, Leon F AD - Center for Population Research, NICHD, NIH, Bethesda, Maryland Y1 - 1983 PY - 1983 DA - 1983 SP - 39 EP - 61 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 467 IS - 1 SN - 0002-7162, 0002-7162 KW - Sustainability Science Abstracts KW - refugees KW - demography KW - USA KW - Politics KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20076374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+American+Academy+of+Political+and+Social+Science&rft.atitle=The+Demography+of+Refugees&rft.au=Huyck%2C+Earl+E%3BBouvier%2C+Leon+F&rft.aulast=Huyck&rft.aufirst=Earl&rft.date=1983-01-01&rft.volume=467&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+American+Academy+of+Political+and+Social+Science&rft.issn=00027162&rft_id=info:doi/10.1177%2F000271628346700104 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - demography; refugees; Politics; USA DO - http://dx.doi.org/10.1177/000271628346700104 ER - TY - CONF T1 - Monitoring breast milk contamination to detect hazards from waste disposal. AN - 15563031; 426330 AB - Human milk is repository for certain classes of long-lived, fat-soluble environmental contaminant chemicals. Some members of this class, such as the chlorinated pesticides and the chlorinated biphenyls, can be expected to be present at chemical waste disposal sites. Analysis of samples of breast milk obtained from women near such a site could provide documentation that exposure has taken place. However, background contamination is present and must be dealt with by the collection of comparison samples. Sample collection can be difficult because of the low level of chemicals being sought, and thus the possibility of sample contamination. The diagnostic and public health consequences of contaminated breast milk are not clear at this time, and thus chemical analysis of milk should be carried out in a research setting. Despite these difficulties, breast milk monitoring has been a successful tool in certain investigations of the spread of environmental chemicals. JF - Environmental Health Perspectives AU - Rogan, W AU - Gladen, B Y1 - 1983 PY - 1983 DA - 1983 SP - 87 EP - 91 VL - 48 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - chemical wastes KW - milk KW - chemical analysis KW - toxicology KW - waste disposal KW - disposal sites KW - contamination KW - public health KW - H SM3.8.2:CHEMICALS (CORROSION) KW - H SE3.23:WASTE DISPOSAL KW - P 6000:TOXICOLOGY AND HEALTH KW - P 4000:WASTE MANAGEMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15563031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Monitoring+breast+milk+contamination+to+detect+hazards+from+waste+disposal.&rft.au=Rogan%2C+W%3BGladen%2C+B&rft.aulast=Rogan&rft.aufirst=W&rft.date=1983-01-01&rft.volume=48&rft.issue=&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Chronic caffeine consumption increases the number of brain adenosine receptors. AN - 15555572; 414695 AB - Caffeine, a potent central stimulant, is known to competitively inhibit the specific binding of both adenosine and benzodiazepine receptor ligands to brain membranes in vitro. In mice receiving a diet containing non-toxic doses of caffeine (200 or 400 mg/kg diet) for periods up to 40 days, a dose-related increase in the number of binding sites for ( super(3)H)-CHA and ( super(3)H) DPX was observed in whole brain membranes without modifications of the receptors' affinity. Furthermore, a transitory increase in the number of ( super(3)H)-DZP binding sites was observed. These preliminary data seem to confirm the involvement of the adenosine receptors in the mode of action of caffeine and may be relevant to the development of both tolerance and dependence to some of the central effects of this compound. JF - Life Sciences AU - Boulenger, J-P AU - Patel, J AU - Post, R M AU - Parma, A M AU - Marangos, P J AD - Lab. Clin. Sci., NIMH, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 1135 EP - 1142 VL - 32 IS - 10 SN - 0024-3205, 0024-3205 KW - receptors KW - caffeine KW - adenosine KW - mice KW - brain KW - Toxicology Abstracts; Biochemistry Abstracts 1: Biological Membranes (till 1993); CSA Neurosciences Abstracts KW - N3 11094:Central nervous system KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15555572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+Sciences&rft.atitle=Chronic+caffeine+consumption+increases+the+number+of+brain+adenosine+receptors.&rft.au=Boulenger%2C+J-P%3BPatel%2C+J%3BPost%2C+R+M%3BParma%2C+A+M%3BMarangos%2C+P+J&rft.aulast=Boulenger&rft.aufirst=J-P&rft.date=1983-01-01&rft.volume=32&rft.issue=10&rft.spage=1135&rft.isbn=&rft.btitle=&rft.title=Life+Sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - brain ER - TY - JOUR T1 - Carcinogenicity of hydroxylated alkylnitrosoureas and of nitrosooxazolidones by mouse skin painting and by gavage in rats. AN - 15532693; 381587 AB - The carcinogenic effectiveness of a number of nitrosoalkylamides related to nitrosoethylurea and nitroso-n-propylurea has been compared by topical application to Swiss mice and by intragastric administration to F344 rats. The mutagenicity to Salmonella seemed not to be quantitatively related to carcinogenicity. Nitroso-5-methyloxazolidone given p.o. to rats induced mainly forestomach neoplasms and a few neoplasms of the duodenum, whereas similar treatment of rats with nitroso-2-hydroxypropylurea induced a high incidence of neoplasms of the thymus, some of the forestomach, and few at any other site. JF - Cancer Research AU - Lijinksy, W AU - Rueber, MD AD - Chem. Carcinog. Program, NCI-Frederick Cancer Res. Fac., Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 214 EP - 221 VL - 43 IS - 1 SN - 0008-5472, 0008-5472 KW - alkylnitrosoureas KW - nitrosooxazolidones KW - mice KW - rats KW - Genetics Abstracts; Toxicology Abstracts KW - carcinogenicity KW - Ames test KW - mutagenicity KW - X 24200:Nitrosamines & related compounds KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15532693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Carcinogenicity+of+hydroxylated+alkylnitrosoureas+and+of+nitrosooxazolidones+by+mouse+skin+painting+and+by+gavage+in+rats.&rft.au=Lijinksy%2C+W%3BRueber%2C+MD&rft.aulast=Lijinksy&rft.aufirst=W&rft.date=1983-01-01&rft.volume=43&rft.issue=1&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity; mutagenicity; Ames test ER - TY - JOUR T1 - Prediction of activated carbon performance for binary vapor mixtures. AN - 14104824; 933105 AB - The adsorption characteristics of a packed bed of carbon granules were determined under dynamic flow conditions for individual vapors and binary vapor mixtures of various compositions and concentrations. Carbon tetrachloride chloroform, and benzene and binary mixtures of these vapors, with wide variations in the mole fraction of each vapor, were used. The authors found that the adsorption space occupied by each vapor was proportional to its mole fraction in the mixture; that is, the vapor's adsorption space was reduced from the adsorption space it would have occupied at the same relative pressure if the carbon bed had been exposed to each vapor separately. The diminished effectiveness of the carbon for one vapor due to the presence of another was quantitatively predicted for binary mixtures by applying this finding to previously established adsorption relationships. JF - American Industrial Hygiene Association Journal AU - Jonas, LA AU - Sansone, E B AU - Farris, T S AD - Environ. Control and Res. Program, NCI-Frederick Cancer Res. Fac., Program Resour., Inc., P.O. Box B, Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 716 EP - 719 VL - 44 IS - 10 SN - 0002-8894, 0002-8894 KW - vapor KW - carbon tetrachloride KW - Pollution Abstracts KW - activated carbon KW - chloroform KW - adsorption KW - benzene KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14104824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Prediction+of+activated+carbon+performance+for+binary+vapor+mixtures.&rft.au=Jonas%2C+LA%3BSansone%2C+E+B%3BFarris%2C+T+S&rft.aulast=Jonas&rft.aufirst=LA&rft.date=1983-01-01&rft.volume=44&rft.issue=10&rft.spage=716&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - activated carbon; adsorption; chloroform; benzene ER - TY - JOUR T1 - The isolation and identification of alfalfa mosaic virus strain causing potato-calico. AN - 14047872; 874058 AB - A potato-calico disease has been found in 1979 in three principal varieties of potatos in Huhhot, Nei Mongol Autonomous Region. The primary symptoms were irregular bright yellow blotches on the middle leaves of infected plants. Then the leaf spots enlarged and sometimes the whole leaflet shows yellow color. The mosaic symptoms are very pronounced and usually the calico symptoms do not become necrotic. A virus was isolated from diseased potato plants and identified on the test plants. According to the symptoms, the causal agent of this potato disease was a AMV strain causing potato-calico. JF - Acta Microbiologica Sinica AU - Zhang, H-L AU - Guo, S-H AD - Dep. Biol., Nei Mongol Univ., Huhhot, People's Rep. China Y1 - 1983 PY - 1983 DA - 1983 SP - 238 EP - 243 VL - 23 IS - 3 SN - 0001-6209, 0001-6209 KW - infection KW - Solanum mosaic virus KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - alfalfa mosaic virus KW - A 01028:Others KW - V 22183:Symptomatology, pathology & etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14047872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Microbiologica+Sinica&rft.atitle=The+isolation+and+identification+of+alfalfa+mosaic+virus+strain+causing+potato-calico.&rft.au=Zhang%2C+H-L%3BGuo%2C+S-H&rft.aulast=Zhang&rft.aufirst=H-L&rft.date=1983-01-01&rft.volume=23&rft.issue=3&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Acta+Microbiologica+Sinica&rft.issn=00016209&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - alfalfa mosaic virus ER - TY - JOUR T1 - Two mini-F-encoded proteins are essential for equipartition. AN - 13931825; 782501 AB - The par region of mini-F is both necessary and sufficient to promote equipartition of plasmid copies to daughter cells. It is approximately 2.5 kb long and contains the coding sequences for two proteins, F1 (41 kDa) and F2 (37 kDa). The authors isolated 13 mutants of a phage arrow right -mini-F hybrid that form unstable plasmids. Two of these putative Par super(-) mutants are fully suppressible nonsense (amber) mutants. One of the amber mutants, par-41, eliminates the synthesis of F1, generating a large nonsense fragment of the protein. The other mutant, par-36, eliminates the synthesis of F2. Thus both proteins appear to be essential for plasmid equipartition. JF - Plasmid AU - Austin, S AU - Wierzbicki, A AD - LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 73 EP - 81 VL - 10 IS - 1 SN - 0147-619X, 0147-619X KW - F factors KW - role KW - partition KW - progeny KW - par region KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - genes KW - Escherichia coli KW - plasmids KW - copy number control KW - gene products KW - J 02760:Plasmids KW - G 07201:F/R PLASMIDS KW - N 14662:Gene regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13931825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plasmid&rft.atitle=Two+mini-F-encoded+proteins+are+essential+for+equipartition.&rft.au=Austin%2C+S%3BWierzbicki%2C+A&rft.aulast=Austin&rft.aufirst=S&rft.date=1983-01-01&rft.volume=10&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Plasmid&rft.issn=0147619X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; genes; plasmids; gene products; copy number control ER - TY - JOUR T1 - Replication-control functions block the induction of an SOS response by a damaged P1 bacteriophage. AN - 13929013; 766745 AB - UV-damaged bacteriophage P1 causes on SOS response in infected bacteria that can be measured colorimetrically with the aid of a lambda p sub(L)-lacZ fusion strain of Escherichia coli). This response is blocked by a P1 prophage. Evidence is offered that the blockage is caused by the concerted action of the incompatibility determinant incA and the immunity (c1 and c4) repressors of the prophage. The authors suggest that indirect induction of lambda by damaged P1 is caused by the abortive initiation of replication in either of two modes, one under incA control, the other under c1 control and indirectly (via ant, the determinant of a repression antagonst) under c4 control. JF - Molecular and General Genetics AU - Yarmolinsky, M B AU - Stevens, E AD - LBI-Basic Res. Program, NCI-Frederick Cancer Res. Fac., Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 140 EP - 148 VL - 192 IS - 1-2 SN - 0026-8925, 0026-8925 KW - induction KW - regulation KW - inhibition KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - phage P1 KW - DNA biosynthesis KW - SOS repair KW - Escherichia coli KW - prophages KW - J 02725:DNA KW - V 22050:Viral genetics including virus reactivation KW - G 07311:PHAGES-INITIAL NAMES KW - J 02750:Phage-host interactions KW - N 14652:DNA repair KW - V 22070:Phage-host interactions including lysogeny & transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13929013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+General+Genetics&rft.atitle=Replication-control+functions+block+the+induction+of+an+SOS+response+by+a+damaged+P1+bacteriophage.&rft.au=Yarmolinsky%2C+M+B%3BStevens%2C+E&rft.aulast=Yarmolinsky&rft.aufirst=M&rft.date=1983-01-01&rft.volume=192&rft.issue=1-2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Molecular+and+General+Genetics&rft.issn=00268925&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - phage P1; Escherichia coli; SOS repair; prophages; DNA biosynthesis ER - TY - JOUR T1 - Partial purification of a placentral interferon with atypical characteristics. AN - 13924268; 774886 AB - Extracts of normal, term placentas, from HIH Swiss mice, were prepared in hypertonic buffer, assayed for interferon (IFN-PI), and fractionated by exclusion chromatography on Bio-Gel P-100. Two peaks of IFN-like activity were identified by species suppression of virus-induced cytopathic effects (CPE). Peak 1, with an estimated molecular weight in excess of 70 kD, was destroyed by acid treatment (pH 2), trypsin, and heat (56 degree C/15 min). Peak 2 has an estimated molecular weight of 27 kD, is partially resistant (50%) to acid treatment (pH 2), but is inactivated by trypsin and heat. IFN in unfractionated placental extracts, as well as in Peak 1 but not in Peak 2, is partially neutralized by antibody to type I ( alpha , beta ), but not antibody to type II ( gamma ) IFN. JF - Journal of Interferon & Cytokine Research AU - Weislow, O S AU - Kiser, R AU - Allen, P T AU - Fowler, A K AD - NCI-Frederick Cancer Res. Facil., Build. 538, Rm. 111-A, Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 291 EP - 298 VL - 3 IS - 3 SN - 0197-8357, 0197-8357 KW - characterization KW - interferon KW - mice KW - placenta KW - purification KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13924268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interferon+%26+Cytokine+Research&rft.atitle=Partial+purification+of+a+placentral+interferon+with+atypical+characteristics.&rft.au=Weislow%2C+O+S%3BKiser%2C+R%3BAllen%2C+P+T%3BFowler%2C+A+K&rft.aulast=Weislow&rft.aufirst=O&rft.date=1983-01-01&rft.volume=3&rft.issue=3&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interferon+%26+Cytokine+Research&rft.issn=01978357&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Systemic suppression of contact hypersensitivity in mice by psoralen plus UVA radiation (PUVA). AN - 13884401; 733990 AB - Treatment of mice with 8-methoxypsoralen plus long-wave UV radiation (UVA, 320-400 nm) decreased their response to contact sensitizers applied subsequently to unirradiated skin. This decreased reactivity exhibited a delayed time course, it affected the afferent but not the efferent phase of the reaction, and it was associated with the development of splenic suppressor cells. These suppressor cells were antigen-specific T lymphocytes, and they prevented the induction, but not the elicitation, of contact hypersensitivity in recipient mice. In all of these characteristics, the decreased reactivity induced by treatment with psoralen plus UVA radiation (PUVA) resembled that produced by UV radiation of shorter wavelengths (< 320 nm). The studies suggest that PUVA treatment may initiate the same sequence of cellular events as does exposure to sunlamp (UVB, 280-320 nm) radiation, leading to preferential activation of the suppressor cell pathway. JF - Journal of Investigative Dermatology AU - Kripke, M L AU - Morison, W L AU - Parrish, JA AD - Immunobiol. Carcinogenesis Lab., LBI-Basic Res. Program, NCI-Frederick Cancer Res. Fac., P.O. Box B, Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 87 EP - 92 VL - 81 IS - 2 SN - 0022-202X, 0022-202X KW - effects on KW - methoxsalen KW - mice KW - Toxicology Abstracts; Immunology Abstracts KW - immunosuppression KW - U.V. radiation KW - contact dermatitis KW - X 24210:Radiation & radioactive materials KW - F 06791:Experimental KW - F 06848:Other hypersensitivity disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13884401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Investigative+Dermatology&rft.atitle=Systemic+suppression+of+contact+hypersensitivity+in+mice+by+psoralen+plus+UVA+radiation+%28PUVA%29.&rft.au=Kripke%2C+M+L%3BMorison%2C+W+L%3BParrish%2C+JA&rft.aulast=Kripke&rft.aufirst=M&rft.date=1983-01-01&rft.volume=81&rft.issue=2&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Journal+of+Investigative+Dermatology&rft.issn=0022202X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - U.V. radiation; contact dermatitis; immunosuppression ER - TY - JOUR T1 - Changes in cortical synaptosomal plasma membrane fluidity and composition in ethanol-dependent rats. AN - 13882396; 733026 AB - Synaptosomal plasma membranes (SPM) were examined from controls; rats acutely treated with single doses of ethanol; a prodromal-detoxication group (dependent-intoxicated); rats undergoing overt ethanol-withdrawal syndrome. Temperature-induced changes in SPM fluidity were smaller during the prodromal detoxication phase. The cholesterol: phospholipid molar ratio significantly increased in SPM from the prodromal-phase rats, but to a lesser extent in rats undergoing ethanol withdrawal syndrome. These studies suggest that physical dependence upon ethanol may be related to changes in synaptosomal membrane composition and viscosity. JF - Psychopharmacology AU - Crews, F T AU - Majchrowicz, E AU - Meeks, R AD - NIAAA, 12501 Washington Ave., Rockville, MD 20852, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 208 EP - 213 VL - 81 IS - 3 SN - 0033-3158, 0033-3158 KW - addiction KW - effects on KW - plasma membranes KW - alcohol KW - rats KW - cortex KW - membrane composition KW - membrane fluidity KW - synaptosomes KW - CSA Neurosciences Abstracts; Biochemistry Abstracts 1: Biological Membranes (till 1993); Toxicology Abstracts KW - N3 11104:Mammals (except primates) KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13882396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Changes+in+cortical+synaptosomal+plasma+membrane+fluidity+and+composition+in+ethanol-dependent+rats.&rft.au=Crews%2C+F+T%3BMajchrowicz%2C+E%3BMeeks%2C+R&rft.aulast=Crews&rft.aufirst=F&rft.date=1983-01-01&rft.volume=81&rft.issue=3&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - membrane fluidity; synaptosomes; membrane composition; cortex ER - TY - JOUR T1 - Quantitative structure-toxicity relationship of chlorinated compounds: a molecular connectivity investigation AN - 13874305; S198309418 AB - The author presents a method for predicting the toxicity of chlorinated organic compounds, based on their molecular connectivity indices. Results obtained when the equations were applied to a number of compounds are tabulated JF - Bulletin of Environmental Contamination and Toxicology AU - Sabljic, A AD - National Institutes of Health, Md. Y1 - 1983 PY - 1983 DA - 1983 SP - 80 EP - 83 VL - 30 SN - 0007-4861, 0007-4861 KW - Jn - bull. of environ. contam. & toxicol. KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13874305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+Environmental+Contamination+and+Toxicology&rft.atitle=Quantitative+structure-toxicity+relationship+of+chlorinated+compounds%3A+a+molecular+connectivity+investigation&rft.au=Sabljic%2C+A&rft.aulast=Sabljic&rft.aufirst=A&rft.date=1983-01-01&rft.volume=30&rft.issue=&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+Environmental+Contamination+and+Toxicology&rft.issn=00074861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Treatment of extensive stage small cell bronchogenic carcinoma. Effects of variation in intensity of induction chemotherapy. AN - 13870709; 718285 AB - Forty-nine consecutive previously untreated patients with extensive stage small cell bronchogenic carcinoma were treated with cyclophosphamide 1,000 mg/m super(2), doxorubicin 50 mg/m super(2), etoposide (VP-16-213) 125 mg/m super(2), and vincristine 1.4 mg/m super(2) (maximum 2 mg) as induction chemotherapy. Thirty-four patients were given high-intensity therapy, receiving these drugs on both Days 1 and 8 of two or three 21-day induction courses. Fifteen other patients were treated with moderate intensity, receiving these drugs only on Day 1 of two 21-day induction courses. In addition to the expected hematologic and infectious complications, there were unexpectedly high frequencies of mucositis, reversible congestive heart failure, and severe peripheral neuropathy in patients treated with high-intensity induction. Only two patients, both in the high-intensity group, were alive and free of disease at 24 months. JF - American Journal of Medicine AU - Brower, M AU - Ihde, D C AU - Johnston-Early, A AU - Bunn, PA Jr AU - Cohen, M H AU - Carney, D N AU - Makuch, R W AU - Matthews, MJ AU - Radice, P A AU - Minna, J D AD - NCI-Navy Med. Oncol. Branch, Build. 1, Rm. 415, Naval Hosp., Bethesda, MD 20814, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 993 EP - 1056 VL - 75 IS - 6 KW - dose-response effects KW - neuropathology KW - failures KW - Toxicology Abstracts KW - heart KW - mucositis KW - antineoplastic drugs KW - man KW - chemotherapy KW - X 24115:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13870709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Medicine&rft.atitle=Treatment+of+extensive+stage+small+cell+bronchogenic+carcinoma.+Effects+of+variation+in+intensity+of+induction+chemotherapy.&rft.au=Brower%2C+M%3BIhde%2C+D+C%3BJohnston-Early%2C+A%3BBunn%2C+PA+Jr%3BCohen%2C+M+H%3BCarney%2C+D+N%3BMakuch%2C+R+W%3BMatthews%2C+MJ%3BRadice%2C+P+A%3BMinna%2C+J+D&rft.aulast=Brower&rft.aufirst=M&rft.date=1983-01-01&rft.volume=75&rft.issue=6&rft.spage=993&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Medicine&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - antineoplastic drugs; chemotherapy; man; heart; mucositis ER - TY - JOUR T1 - Bathocuproine sulphonate: a tissue culture-compatible indicator of copper-mediated toxicity AN - 13870445; S198310160 AB - Graphs are used to report the results of experiments which show that the non-toxic, copper-specific, chelating agent, bathocuproine sulphonate is a reliable indicator of copper-mediated toxicity in tissue culture, while its lack of toxicity, and its specificity for copper, suggest that it could be a therapeutic agent for alleviating copper toxicity in vivo. A bibliography of 16 references is appended. JF - Nature AU - Mohindru, A AU - Fisher, J M AU - Rabinovitz, M AD - National Institutes of Health, Bethesda Y1 - 1983 PY - 1983 DA - 1983 SP - 64 EP - 65 VL - 303 IS - 5912 SN - 0028-0836, 0028-0836 KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13870445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Bathocuproine+sulphonate%3A+a+tissue+culture-compatible+indicator+of+copper-mediated+toxicity&rft.au=Mohindru%2C+A%3BFisher%2C+J+M%3BRabinovitz%2C+M&rft.aulast=Mohindru&rft.aufirst=A&rft.date=1983-01-01&rft.volume=303&rft.issue=5912&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Electrochemical measurements in flowing solutions AN - 13867942; 198302508 AB - The application of electrochemical measurements to flowing environments is reviewed, and how these measurements can provide data on corrosion rates, corrosion mechanisms, characteristic hydrodynamic features and solution composition is demonstrated. The theoretical principles associated with these applications are discussed and a rig for making the measurements in flowing solutions is described with the characteristics of different specimens used. A cell with impinging jet, has been developed for testing the importance of some hydrodynamic variables on corrosion processes. Corrosion rates are not always simply related to mass transfer even when they are controlled by diffusion, especially for specimens with non-uniform flow conditions. A bibliography of 101 references is appended. JF - Corrosion Science AU - Poulson, D AD - N.E.I. Power Engineering Ltd, Gateshead Y1 - 1983 PY - 1983 DA - 1983 SP - 391 EP - 430 VL - 23 IS - 4 SN - 0010-938X, 0010-938X KW - Equipment KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13867942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Corrosion+Science&rft.atitle=Electrochemical+measurements+in+flowing+solutions&rft.au=Poulson%2C+D&rft.aulast=Poulson&rft.aufirst=D&rft.date=1983-01-01&rft.volume=23&rft.issue=4&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Corrosion+Science&rft.issn=0010938X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Statistical methods for in vitro cell survival assays AN - 13867426; S198411939 AB - Statistical methods are presented for estimating and comparing survival curves obtained from experiments in which cells are exposed in vitro to increasing doses of a DNA-damaging agent. Most of the estimation methods represent an application in the linear regression setting of principles and methods presented by Cochran (1954) and are closely related to methods used by Hyde (1980). They are applicable in a variety of cell survival assays and are illustrated in the evaluation of two sets of experiments in which the colony-forming ability of fibroblast cell lines from 9 muscular dystrophy patients and 17 normal individuals was studied after exposure to N-methyl-N-nitro-N-nitrosoguanidine . JF - Mutation Research AU - Tarone, R E AU - Scudiero, DA AU - Robbins, J H AD - National Cancer Institute, Bethesda, Md. Y1 - 1983 PY - 1983 DA - 1983 SP - 79 EP - 96 VL - 111 IS - 1 SN - 0027-5107, 0027-5107 KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13867426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Statistical+methods+for+in+vitro+cell+survival+assays&rft.au=Tarone%2C+R+E%3BScudiero%2C+DA%3BRobbins%2C+J+H&rft.aulast=Tarone&rft.aufirst=R&rft.date=1983-01-01&rft.volume=111&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - The use of Neurospora in the evaluation of the mutagenic activity of environmental chemicals AN - 13863796; 198303418 AB - In Neurospora, the genetic characterization of ad-3 mutants (N23 and N24) which revert by base-pair substitution or frameshift mutation, provides a useful method for evaluating the spectrum of specific locus mutations produced by environmental mutagens. The Neurospora ad-3 assay system provides a mechanism for generating a database useful for risk estimation to humans exposed to such mutagens. JF - Environmental Mutagenesis AU - de Serres, FJ AD - National Institute of Environmental Health, Sciences, Research Triangle Park, N.C. Y1 - 1983 PY - 1983 DA - 1983 SP - 341 EP - 351 VL - 5 KW - Hazard KW - Neurospora KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13863796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Mutagenesis&rft.atitle=The+use+of+Neurospora+in+the+evaluation+of+the+mutagenic+activity+of+environmental+chemicals&rft.au=de+Serres%2C+FJ&rft.aulast=de+Serres&rft.aufirst=FJ&rft.date=1983-01-01&rft.volume=5&rft.issue=&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Environmental+Mutagenesis&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Interleukin-2 and interleukin-3: Suspension cultures of constitutive producer cell lines. AN - 13856546; 711276 AB - The ability to produce large quantities of lectin-free lymphokines constituitively in suspension culture would provide material not only for protein sequencing but also for in vitro maintenance of T-cell lines and evaluation of potential in vivo antitumor therapeutic applications. The authors have been developing two suspension culture systems for producing large quantities of interleukin 2 (T-cell growth factor, TCGF; IL-2), which is involved in the growth promotion of T-cells and in the formation of cytotoxic T-lymphocytes and of interleukin 3 (IL-3), a proposed regulator of early stages of T-cell maturation. JF - ADV. BIOTECHNOL. PROCESS. AU - Klein, F AU - Ricketts, R AU - Pickle, D AU - Flickinger, M C AD - NCI-Frederick Cancer Res. Facil., Ferment. Program, Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 111 EP - 134 VL - 2 KW - cell culture KW - production KW - fermenters KW - interleukin 2 KW - interleukin 3 KW - Biotechnology and Bioengineering Abstracts KW - ISBN 0-8451-3201-6 KW - W 30404:Other peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13856546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ADV.+BIOTECHNOL.+PROCESS.&rft.atitle=Interleukin-2+and+interleukin-3%3A+Suspension+cultures+of+constitutive+producer+cell+lines.&rft.au=Klein%2C+F%3BRicketts%2C+R%3BPickle%2C+D%3BFlickinger%2C+M+C&rft.aulast=Klein&rft.aufirst=F&rft.date=1983-01-01&rft.volume=2&rft.issue=&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=ADV.+BIOTECHNOL.+PROCESS.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Methods for transport and long-term maintenance of spiny dogfish sharks. AN - 13845118; 699468 AB - Spiny dogfish shark (Squalus acanthias ) embryos were transported from Maine to a Maryland laboratory where they were maintained for20 months. During this maintenance period, these sharks progressed from a yolk-sac stage to feeding stage. Animals were maintained at 10 degree C in artificial seawater containing penicillin and streptomycin and were fed frozen brine shrimp and krill. The ease with which these animals could be maintained in the laboratory for an extended period of time greatly enhanced their usefulness as an experimental animal in a variety of studies. JF - Laboratory Animal Science AU - Jones, R T AU - Hudson, E A AU - Andrews, J C AD - Exp. Pathol. Lab., NCI-FCRF, Build. 560, Rm. 32-60, Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 388 EP - 389 VL - 33 IS - 4 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA Aquaculture Abstracts KW - Marine KW - transportation KW - Squalus acanthias KW - rearing KW - Q3 08582:Fish culture KW - Q1 08582:Fish culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13845118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+Animal+Science&rft.atitle=Methods+for+transport+and+long-term+maintenance+of+spiny+dogfish+sharks.&rft.au=Jones%2C+R+T%3BHudson%2C+E+A%3BAndrews%2C+J+C&rft.aulast=Jones&rft.aufirst=R&rft.date=1983-01-01&rft.volume=33&rft.issue=4&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=Laboratory+Animal+Science&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-05 N1 - SubjectsTermNotLitGenreText - transportation; rearing; Squalus acanthias; Marine ER - TY - JOUR T1 - Quantitation of halogenated aromatic compounds by gas chromatography-mass spectrometry AN - 13838469; S198516724 AB - A quantitative comparison was made of gas chromatography/mass spectrometry and gas chromatography/hydrogen flame ionization detection (GC-HFID) to 5 classes of halogenated aromatic compounds (polychlorinated dibenzo-p-dioxins, polychlorinated naphthalenes, polychlorinated dibenzofurans, polychlorinated diphenyl ethers and polychlorinated biphenyls). Selective ion monitoring of ions in the molecular cluster and total ion current peak areas gave a good approximation to relative concentrations based on GC-HFID peak areas. JF - Journal of Chromatography. Biomedical Applications AU - Parker, CE AU - Albro, P W AU - Bobenrieth, MJ AU - Cochran, T W AU - Robinson, J D AD - National Institute of Environmental Health Sciences, Reearch Triangle Park, N.C. Y1 - 1983 PY - 1983 DA - 1983 SP - 1 EP - 11 VL - 278 IS - 1 KW - Diphenyl ether KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13838469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography.+Biomedical+Applications&rft.atitle=Quantitation+of+halogenated+aromatic+compounds+by+gas+chromatography-mass+spectrometry&rft.au=Parker%2C+CE%3BAlbro%2C+P+W%3BBobenrieth%2C+MJ%3BCochran%2C+T+W%3BRobinson%2C+J+D&rft.aulast=Parker&rft.aufirst=CE&rft.date=1983-01-01&rft.volume=278&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography.+Biomedical+Applications&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - The hyperimmunoglobulin E recurrent-infection (Job's) syndrome. A review of the NIH experience and the literature. AN - 13837543; 698082 AB - The hyperimmunoglobulin E recurrent-infection syndrome (HIE) entails a disorder of recurrent bacterial infections of the skin and sinopulmonary tract commencing in infancy or early childhood in the presence of serum levels of IgE which are at least 10 times normal (> 2,000 IU/ML). Variable concomitants of HIE are coarse facies, chronic eczematoid rashes, cold cutaneous abcesses, mild eosinophilia, mucocutaneous candidiasis, and a neutrophil chemotactic defect. The Bacterial which commonly infect these patients are Staphylococcus aureus and Haemophilus influenzae although Streptococcus pneumoniae and enteric gram-negative rods are seen in some cases. HIE patients neutrophils display a variable chemotactic defect, and their mononuclear cells variably produce an inhibition of neutrophil chemotaxis. The production of the inhibitor correlates with the in vitro chemotactic defect. JF - Medicine AU - Donabedian, H AU - Gallin, JI AD - Bacterial Dis. Sect., Lab. Clin. Invest., NIAID, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 195 EP - 208 VL - 62 IS - 4 KW - infection KW - opportunistic infection KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - leukocytes (neutrophilic) KW - immunoglobulin E KW - chemotaxis KW - hypergammaglobulinemia KW - skin KW - immunodeficiency KW - respiratory tract KW - bacteria KW - man KW - J 02843:Skin KW - F 06865:Hypergammaglobulinemia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13837543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicine&rft.atitle=The+hyperimmunoglobulin+E+recurrent-infection+%28Job%27s%29+syndrome.+A+review+of+the+NIH+experience+and+the+literature.&rft.au=Donabedian%2C+H%3BGallin%2C+JI&rft.aulast=Donabedian&rft.aufirst=H&rft.date=1983-01-01&rft.volume=62&rft.issue=4&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Medicine&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - skin; respiratory tract; hypergammaglobulinemia; immunoglobulin E; leukocytes (neutrophilic); chemotaxis; immunodeficiency; bacteria; man ER - TY - JOUR T1 - Asbestos and benzo(a)pyrene synergism in the transformation of Syrian hamster embryo cells. AN - 13837405; 694417 AB - Four varieties of asbestos fibers, crocidolite, anthophyllite, amosite, and chrysotile, induced a low rate of morphologic transformation in Syrian hamster cells. Of the four tested, chrysotile was the most lethal as reflected by colony survival. When cells were exposed to 1 mu g of benzo(a)pyrene (BP)/l ml medium or 3 J/m super(2) ultraviolet irradiation and to different concentrations of the asbestos fibers, an enhancement of transformation occurred only with BP. The enhancement was dose responsive with all fiber species except for amosite which was dose independent. The synergistic activity of BP and asbestos suggests that asbestos facilitates the transport of BP to the cell site(s) critical for transformation. The results provide a basis for investigating the carcinogenic and cocarcinogenic potential of asbestos fibers in mammalian cells. JF - Pharmacology AU - DiPaolo, JA AU - DeMarinis, A J AU - Doniger, J AD - NCI, NIH, Build. 37, Rm. 2A-19, 9000 Rockville Pike, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 65 EP - 73 VL - 27 IS - 2 SN - 0031-7012, 0031-7012 KW - fibers KW - asbestos KW - benzo(a)pyrene KW - hamsters KW - Toxicology Abstracts KW - embryo cells KW - transformation KW - X 24190:Polycyclic hydrocarbons KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13837405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology&rft.atitle=Asbestos+and+benzo%28a%29pyrene+synergism+in+the+transformation+of+Syrian+hamster+embryo+cells.&rft.au=DiPaolo%2C+JA%3BDeMarinis%2C+A+J%3BDoniger%2C+J&rft.aulast=DiPaolo&rft.aufirst=JA&rft.date=1983-01-01&rft.volume=27&rft.issue=2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Pharmacology&rft.issn=00317012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - transformation; embryo cells ER - TY - JOUR T1 - Vectors for constructing hybrid genes. AN - 13828196; 688626 AB - This article reviews the emergence of gene fusion technology. The requirements for the construction of active hybrid genes are outlined with an emphasis on fusions with the lac operon of Escherichia coli . The use of cloning vectors for the construction of gene fusions is discussed in detail. Plasmid vectors designed for cloning any "open reading frame" specified by DNA fragments from any source are also described. Finanlly, specific research applications for hybrid lacZ genes and the proteins specified by these constructions are presented in terms of existing problems and possible future developments. JF - Biotechniques AU - Berman, M L AD - NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 178 EP - 183 VL - 1 IS - 4 SN - 0736-6205, 0736-6205 KW - lactose operon KW - hybrids KW - Escherichia coli KW - cloning vectors KW - gene fusion KW - genes KW - operons KW - reviews KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - N 14682:Cloning vectors KW - W 30114:Cloning vectors KW - G 07120:Recombinant DNA/Genetic engineering KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13828196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechniques&rft.atitle=Vectors+for+constructing+hybrid+genes.&rft.au=Berman%2C+M+L&rft.aulast=Berman&rft.aufirst=M&rft.date=1983-01-01&rft.volume=1&rft.issue=4&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Biotechniques&rft.issn=07366205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; operons; cloning vectors; genes; reviews; gene fusion ER - TY - JOUR T1 - "Joining peptide" of pro-opiomelanocortin. I. Radioimmunoassay and extraction of related peptides from pituitary glands. AN - 13811553; 672012 AB - In order to immunoassay the specific region of bovine pituitary pro-opiomelanocortin (POMC) between corticotropin ACTH and gamma -MSH, referred to as "joining peptide," antisera were prepared against the synthetic amidated decapeptide Val-Ala-Val-Gly-Glu-Gly-Pro-Gly-Pro-Arg. NH sub(2). The non-amidated peptide represents residues - 23 to - 14 of bovine POMC. An NH sub(2)-terminal tyrosine analog of the decapeptide was used as the radioligand. Under optimal conditions, immunoassays with selected antisera exhibited a sensitivity (50% displacement of the radioligand) toward the decapeptide in the range of 31-55 pg. Immunoreactivity found in extracts of fresh or lyophilized bovine pituitary glands displaced the iodinated Tyr-decapeptide in the RIA in a parallel manner. The amount of immunoreactive (ir)-material was dependent upon the state of preservation of the tissue, the method of extraction, and the particular antiserum used. Extractable immunoreactivity was separated into low and high molecular weight peptides using gel chromatography (G-75). Additional ir-material appeared in the void volume. Thus, these antisera have the capacity to interact not only with a region of the joining peptide but also with its larger, and apparent precursor forms. The immunoassay developed should be valuable in understanding the disposition and processing this specific region of POMC. JF - Peptides AU - Erisman, MD AU - Lazarus, L H AU - Jahnke, G D AU - Soldato, C M AU - DiAugustine, R P AD - Peptide Neurochem. Workgroup, LBNT, NIEHS, P.O. Box 12233, Research Traingle Park, NC 27709, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 475 EP - 482 VL - 4 IS - 4 SN - 0196-9781, 0196-9781 KW - cattle KW - corticotropin KW - isolation KW - linkage KW - melanotropin KW - peptides KW - pituitary KW - proopiomelanocortin KW - radioimmunoassay KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13811553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Peptides&rft.atitle=%22Joining+peptide%22+of+pro-opiomelanocortin.+I.+Radioimmunoassay+and+extraction+of+related+peptides+from+pituitary+glands.&rft.au=Erisman%2C+MD%3BLazarus%2C+L+H%3BJahnke%2C+G+D%3BSoldato%2C+C+M%3BDiAugustine%2C+R+P&rft.aulast=Erisman&rft.aufirst=MD&rft.date=1983-01-01&rft.volume=4&rft.issue=4&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Peptides&rft.issn=01969781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Escherichia coli plasmid vectors for high-level regulated expression of the bacteriophage lambda xis gene product. AN - 13792971; 655416 AB - The bacteriophage lambda Xis protein is one of the proteins required for site-specific excisive recombination by which the lambda prophage is excised from the Escherichia coli bacterial chromosome. The authors cloned the lambda xis gene under the control of several prokaryotic promoters to obtain a sufficient source of the protein for biochemical studies. E. coli lac promoter and lambda p sub(L) promoter fusions to the xis) gene produce high levels of Xis protein. Induction of the expression vectors results in a 10- to 50-fold increase in Xis activity. In addition, one of these plasmids allows the control of xis expression in vivo. JF - Gene AU - Abremski, K AU - Hoess, R AD - Lab. Mol. Biol., LBI-Basic Res. Program, NCI-Frederick Cancer Res. Fac., P.O. Box B, Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 49 EP - 58 VL - 25 IS - 1 SN - 0378-1119, 0378-1119 KW - xis gene KW - lac promoter KW - regulation KW - Escherichia coli KW - gene expression KW - genes KW - phage lambda KW - promoters KW - transformation KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - W 30124:TRANSFORMATION KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13792971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Escherichia+coli+plasmid+vectors+for+high-level+regulated+expression+of+the+bacteriophage+lambda+xis+gene+product.&rft.au=Abremski%2C+K%3BHoess%2C+R&rft.aulast=Abremski&rft.aufirst=K&rft.date=1983-01-01&rft.volume=25&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - phage lambda; Escherichia coli; transformation; genes; promoters; gene expression ER - TY - JOUR T1 - Hepatic microsomal NADPH-cytochrome P-450 reductase from little skate, Raja erinacea . Comparison of thermolability and other molecular properties with a mammalian enzyme. AN - 13785474; 645905 AB - Components of little skate (R. erinacea ) (an elasmobranch) and rabbit hepatic microsomal cytochrome P-450 dependent monooxygenase systems were examined for differences which might explain the decreasing xenobiotic-metabolizing activity of little skate microsomes assayed at temperatures above 30 degree C. The proportion of saturated fatty acids in microsomal lipids and the habitat temperature are both lower in skate as compared to rabbit, which is consistent with the known adaptive pattern. The more thermolabile enzyme of the skate system in microsomal preparations is NADPH-cytochrome P-450 reductase. The optimal assay temperature for purified skate reductase (30 degree C) is 10 degree C lower than that for the purified rabbit reductase. The purified skate reductase differs from rabbit reductase in monomeric molecular weight, in peptides produced by partial proteolysis, in immunochemical properties, but not in flavin content. JF - Chemico-Biological Interactions AU - Pohl, R J AU - Serabjit-Singh, C J AU - Slaughter AU - Albro, P W AU - Fouts, J R AU - Philpot, R M AD - NIEHS/NIH, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 283 EP - 294 VL - 45 IS - 3 SN - 0009-2797, 0009-2797 KW - NADPH-cytochrome reductase KW - Raja erinacea KW - biochemistry KW - comparative studies KW - comparison KW - enzymes KW - lipids KW - microsomes KW - protein structure KW - proteins KW - rabbits KW - thermal stability KW - Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - Q1 08346:Physiology, biochemistry, biophysics KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13785474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-Biological+Interactions&rft.atitle=Hepatic+microsomal+NADPH-cytochrome+P-450+reductase+from+little+skate%2C+Raja+erinacea+.+Comparison+of+thermolability+and+other+molecular+properties+with+a+mammalian+enzyme.&rft.au=Pohl%2C+R+J%3BSerabjit-Singh%2C+C+J%3BSlaughter%3BAlbro%2C+P+W%3BFouts%2C+J+R%3BPhilpot%2C+R+M&rft.aulast=Pohl&rft.aufirst=R&rft.date=1983-01-01&rft.volume=45&rft.issue=3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Chemico-Biological+Interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - lipids; biochemistry; enzymes; proteins; Marine ER - TY - JOUR T1 - The effect of calf serum on human lymphoblastoid cell-derived interferon production. AN - 13776007; 640838 AB - Substitution of low-cost calf serum for fetal bovine serum was evaluated in Namalva cell production of human alpha-lymphoblastoid interferon (HuIFN- alpha (Ly)) in 50-liter fermentors. Namalva cell growth and IFN yields were greatly reduced and protein precipitate weight increased from calf serum-supplemented cell cultures. The overall reduction in IFN production was greater than threefold, making the substitution impractical. JF - Journal of Interferon & Cytokine Research AU - Klein, F AU - Ricketts, R T AU - Jones, W I AU - Clark, P M AD - NCI-Frederick Cancer Res. Fac., Ferment. Program, P.O. Box B, Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 115 EP - 120 VL - 3 IS - 1 SN - 0197-8357, 0197-8357 KW - effects on KW - Namalva cell KW - growth KW - production KW - cattle KW - interferon KW - serum KW - Biotechnology and Bioengineering Abstracts KW - W 30403:Interferon UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13776007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interferon+%26+Cytokine+Research&rft.atitle=The+effect+of+calf+serum+on+human+lymphoblastoid+cell-derived+interferon+production.&rft.au=Klein%2C+F%3BRicketts%2C+R+T%3BJones%2C+W+I%3BClark%2C+P+M&rft.aulast=Klein&rft.aufirst=F&rft.date=1983-01-01&rft.volume=3&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interferon+%26+Cytokine+Research&rft.issn=01978357&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Carcinogenesis by combinations of N-nitroso compounds in rats. AN - 13775224; 645050 AB - Five N-nitroso compounds were administered individually or in various combinations to groups of 20 female F344 rats to examine possible additive or synergistic effects on mortality rate and the induction of tumours. The evidence suggests that additive or synergistic effects of combinations of N-nitroso compounds at low dose rates can be demonstrated in small groups of rats. JF - Food and Chemical Toxicology AU - Lijinsky, W AU - Reuber, MD AU - Riggs, C W AD - Chem. Carcinog. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 601 EP - 606 VL - 21 IS - 5 SN - 0278-6915, 0278-6915 KW - combination KW - N-nitroso compounds KW - tumors KW - rats KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - carcinogenicity KW - carcinogenesis KW - mortality KW - synergism KW - X 24200:Nitrosamines & related compounds KW - H SM10.21:CANCER UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13775224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Carcinogenesis+by+combinations+of+N-nitroso+compounds+in+rats.&rft.au=Lijinsky%2C+W%3BReuber%2C+MD%3BRiggs%2C+C+W&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1983-01-01&rft.volume=21&rft.issue=5&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity; rats; synergism; mortality; carcinogenesis; tumors ER - TY - JOUR T1 - Erythema and desquamation after high-dose methotrexate. AN - 13775071; 644989 AB - An erythematous, desquamating rash of the hands developed in three patients with non-Hodgkin's lymphoma after treatment with high-dose methotrexate. The patients received methotrexate on ProMACE combination chemotherapy. After ProMACE induction, patients received consolidation with standard MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) chemotherapy and then late intensification with ProMACE. JF - Annals of Internal Medicine AU - Doyle, LA AU - Berg, C AU - Bottino, G AU - Chabner, B AD - Rm. 415, Tower 1, NCI-Navy Med. Oncol. Branch, Natl. Naval Med. Cent., Bethesda, MD 20814, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 611 EP - 612 VL - 98 IS - 5 SN - 0003-4819, 0003-4819 KW - case reports KW - side effects KW - methotrexate KW - Toxicology Abstracts KW - erythema KW - antineoplastic drugs KW - man KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13775071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Internal+Medicine&rft.atitle=Erythema+and+desquamation+after+high-dose+methotrexate.&rft.au=Doyle%2C+LA%3BBerg%2C+C%3BBottino%2C+G%3BChabner%2C+B&rft.aulast=Doyle&rft.aufirst=LA&rft.date=1983-01-01&rft.volume=98&rft.issue=5&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Annals+of+Internal+Medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - antineoplastic drugs; erythema; man ER - TY - JOUR T1 - Teratogenicity study of ethylene glycol in rats. AN - 13774743; 645262 AB - Ethylene glycol was administered in the diet to pregnant Fischer 344 rats on days 6 through 15 of gestation. Target dosage levels were 1.0, 0.2, 0.04, and 0.00 g/kg/day. There was no maternal toxicity, embryotoxicity, or increased incidence of malformations in fetuses from dosed dams. Positive control dams received 500 mg/kg of hydroxyurea on gestation day 11 and had fetuses with numerous soft tissue and skeletal malformations. Results are interpreted as preliminary indication of lack of teratogenicity of ethylene glycol. JF - Drug and Chemical Toxicology AU - Maronpot, R R AU - Zelenak, J P AU - Weaver, E V AU - Smith, N J AD - Natl. Toxicol. Prog., NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 579 EP - 594 VL - 6 IS - 6 SN - 0148-0545, 0148-0545 KW - ethylene glycol KW - rats KW - Toxicology Abstracts KW - intrauterine exposure KW - teratogenicity KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13774743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Chemical+Toxicology&rft.atitle=Teratogenicity+study+of+ethylene+glycol+in+rats.&rft.au=Maronpot%2C+R+R%3BZelenak%2C+J+P%3BWeaver%2C+E+V%3BSmith%2C+N+J&rft.aulast=Maronpot&rft.aufirst=R&rft.date=1983-01-01&rft.volume=6&rft.issue=6&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Drug+and+Chemical+Toxicology&rft.issn=01480545&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - intrauterine exposure; teratogenicity ER - TY - JOUR T1 - X-ray analysis of the eye lens protein gamma -II crystallin at 1 multiplied by 9 A resolution. AN - 13765777; 625036 AB - The authors report the X-ray structure analysis and refinement at 1 multiplied by 9 angstrom resolution of calf gamma -II crystallin. JF - Journal of Molecular Biology AU - Wistow, G AU - Turnell, B AU - Summers, L AU - Slingsby, C AU - Moss, D AU - Miller, L AU - Lindley, P AU - Blundell, T AD - Lab. Mol. Genet. NICHD. Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 175 EP - 202 VL - 170 IS - 1 SN - 0022-2836, 0022-2836 KW - X-ray crystallography KW - cattle KW - eye lens KW - gamma -crystallin KW - structure KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13765777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=X-ray+analysis+of+the+eye+lens+protein+gamma+-II+crystallin+at+1+multiplied+by+9+A+resolution.&rft.au=Wistow%2C+G%3BTurnell%2C+B%3BSummers%2C+L%3BSlingsby%2C+C%3BMoss%2C+D%3BMiller%2C+L%3BLindley%2C+P%3BBlundell%2C+T&rft.aulast=Wistow&rft.aufirst=G&rft.date=1983-01-01&rft.volume=170&rft.issue=1&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Characterization of the locomotor stimulant action of nicotine in tolerant rats. AN - 13751065; 624185 AB - Tests of locomotor activity (photocell cages) were used to investigate the development of tolerance to nicotine in rats. Repeated exposure to the apparatus did not influence the rate at which tolerance was acquired. Comparisons of (+)-nicotine and (-)-nicotine in tolerant rats showed that the (-)-isomer was at least ten times more potent in stimulating motor activity. Subcutaneous pretreatment with mecamylamine completely prevented the locomotor stimulant action of nicotine in tolerant rats, whereas chlorisondamine only partially reduced it. When mecamylamine was given after an injection of nicotine, the locomotor stimulant action of nicotine was blocked, and nicotine actually reduced activity. A single intraventricular dose of chlorisondamine blocked the stimulant actions of nicotine for the duration of the experiment. JF - British Journal of Pharmacology AU - Clarke, PBS AU - Kumar, R AD - Biol. Psychiatry Branch, NIMH, Build. 10, Rm. 3N212, 9000 Rockville Pike, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 587 EP - 594 VL - 80 IS - 3 SN - 0007-1188, 0007-1188 KW - isomers KW - effects on KW - rats KW - nicotine KW - Toxicology Abstracts KW - locomotor activity KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13751065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Pharmacology&rft.atitle=Characterization+of+the+locomotor+stimulant+action+of+nicotine+in+tolerant+rats.&rft.au=Clarke%2C+PBS%3BKumar%2C+R&rft.aulast=Clarke&rft.aufirst=PBS&rft.date=1983-01-01&rft.volume=80&rft.issue=3&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Pharmacology&rft.issn=00071188&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - locomotor activity ER - TY - JOUR T1 - Characteristics of tubulin aggregation by tubulin-binding proteins from brain and by synthetic polycations. AN - 13731425; 602895 AB - A basic fraction from brain cytosol was found to contain two or more tubulin-binding proteins, able to induce aggregation of tubulin accompanied by hydrolysis of GTP. In some respects tubulin aggregation by the brain proteins was similar to its aggregation by polylysine. The burst of GTP hydrolysis accompanying tubulin aggregation by polylysine had the following characteristics: enhanced by salt and abolished by low temperature: not stoichiometric with the amount of tubulin precipitated and acutally maximal at relatively low polylysine concentration: uncoupled temporally from aggregation, which occurred over a much shorter interval. JF - International Journal of Biochemistry & Cell Biology AU - Miyatake, K AU - Flavin, M AD - Sect. Organelle Biochem., Lab. Cell Biol., NHLBI, Build. 3, Rm. B1-22, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 1305 EP - 1312 VL - 15 IS - 11 SN - 0020-711X, 0020-711X KW - aggregation KW - brain KW - induction KW - poly(lysine) KW - tubulin KW - tubulin-binding protein KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - N3 11070:Neurochemistry and cellular biology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13731425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Biochemistry+%26+Cell+Biology&rft.atitle=Characteristics+of+tubulin+aggregation+by+tubulin-binding+proteins+from+brain+and+by+synthetic+polycations.&rft.au=Miyatake%2C+K%3BFlavin%2C+M&rft.aulast=Miyatake&rft.aufirst=K&rft.date=1983-01-01&rft.volume=15&rft.issue=11&rft.spage=1305&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Biochemistry+%26+Cell+Biology&rft.issn=0020711X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - aggregation; brain ER - TY - JOUR T1 - Complete amino acid sequence of human T-cell leukemia virus structural protein p15. AN - 13726439; 603078 AB - The complete amino acid sequence of human T-cell leukemia virus (HTLV) structural protein p15 has been determined. The intact protein and peptides generated by enzymatic digestion and acid cleavage were purified by reversed-phase liquid chromatography and subjected to semi-automated Edman degradation. HTLV p15 is a basic linear polypeptide composed of 85 amino acids with M sub(r) 9458. The primary structure indicates that HTLV p15 is homologous to the nucleic acid binding proteins of other type-C retroviruses and especially related to bovine leukemia virus p12. JF - FEBS Letters AU - Copeland, T D AU - Oroszlan, S AU - Kalyanaraman, V S AU - Sarngadharan, M G AU - Gallo, R C AD - Lab. Mol. Virol. and Carcinogenesis, LBI-Basic Res. Prog., NCI-Frederick Cancer Res. Facility, Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 390 EP - 395 VL - 162 IS - 2 SN - 0014-5793, 0014-5793 KW - T cell leukemia virus KW - amino acid sequence KW - structural proteins KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - V 22032:Viral proteins KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13726439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Complete+amino+acid+sequence+of+human+T-cell+leukemia+virus+structural+protein+p15.&rft.au=Copeland%2C+T+D%3BOroszlan%2C+S%3BKalyanaraman%2C+V+S%3BSarngadharan%2C+M+G%3BGallo%2C+R+C&rft.aulast=Copeland&rft.aufirst=T&rft.date=1983-01-01&rft.volume=162&rft.issue=2&rft.spage=390&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - structural proteins; amino acid sequence ER - TY - JOUR T1 - Open reading frame expression vectors: A general method for antigen production in Escherichia coli using protein fusions to beta -galactosidase. AN - 13716315; 537906 AB - The authors have developed an Escherichia coli plasmid vector for the identification and expression of foreign DNA segments that are open reading frames (ORFs). The 5' end of ompF , an E. coli gene encoding an abundant outer membrane protein, is used to provide a strong, regulate promoter, translation initiation site, and signal sequence for export from the cytoplasm. To demonstrate the vector's utility, they inserted a fragment from the herpes virus thymidine kinase gene and used the resulting tribrid protein to raise antibodies that precipitate thymidine kinase from herpes virus-infected cells. They also inserted a fragment from the E. coli, lexA gene to produce a tribrid protein that is precipitated by antiserum raised with LexA protein. Thus, tribrid fusion proteins can be used to produce or detect antibodies and also to identify the product of a cloned gene. JF - Proceedings of the National Academy of Sciences, USA AU - Weinstock, G M AU - Ap Rhys, C AU - Berman, M L AU - Hampar, B AU - Jackson, D AU - Silhavy, T J AU - Weisemann, J AU - Zweig, M AD - LBI-Basic Res. Prog., Lab. Genet. and Recomb. DNA, NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 4432 EP - 4436 VL - 80 IS - 14 SN - 0027-8424, 0027-8424 KW - methodology KW - identification KW - recombinants KW - termination KW - dissociation KW - use KW - beta -D-galactosidase KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - codons KW - genes KW - Escherichia coli KW - gene expression KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13716315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Open+reading+frame+expression+vectors%3A+A+general+method+for+antigen+production+in+Escherichia+coli+using+protein+fusions+to+beta+-galactosidase.&rft.au=Weinstock%2C+G+M%3BAp+Rhys%2C+C%3BBerman%2C+M+L%3BHampar%2C+B%3BJackson%2C+D%3BSilhavy%2C+T+J%3BWeisemann%2C+J%3BZweig%2C+M&rft.aulast=Weinstock&rft.aufirst=G&rft.date=1983-01-01&rft.volume=80&rft.issue=14&rft.spage=4432&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; gene expression; codons; genes ER - TY - JOUR T1 - Statistical analysis and sample-size determinations for mutagenicity experiments with binomial responses. AN - 13702879; 571672 AB - Two statistical analyses are studied for their applicability to mutagenicity experiments that produce binomial responses from a control group and a single treated group. Attention is focused on experiments with (1) group sample sizes greater than 500 and (2) a probability less than .05 for a binary observation from any experimental unit being "positive." Based on extensive numerical results, the conclusion is drawn that the normal test is the preferred analysis for experiments in which the ratio of the two sample sizes is between 0.80 and 1.25. On the further assumption that an experiment is to be conducted with equal experimental group sample sizes, recommendations are offered for values of this common sample size needed to achieve a specified power, ie, a degree of assurance of detecting a postulated level of mutagenic effect. JF - ENVIRON. MUTAGENESIS. AU - Margolin, B H AU - Collings, B J AU - Mason, J M AD - Biometry & Risk Assess. Program, NIEHS, Research Triangle Park, NC 27709, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 705 EP - 716 VL - 5 IS - 5 KW - statistical analysis KW - samples KW - size KW - Toxicology Abstracts; Genetics Abstracts KW - mutagenicity testing KW - G 07220:General theory/testing systems KW - X 24221:Toxicity testing KW - G 07300:Theoretical genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13702879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ENVIRON.+MUTAGENESIS.&rft.atitle=Statistical+analysis+and+sample-size+determinations+for+mutagenicity+experiments+with+binomial+responses.&rft.au=Margolin%2C+B+H%3BCollings%2C+B+J%3BMason%2C+J+M&rft.aulast=Margolin&rft.aufirst=B&rft.date=1983-01-01&rft.volume=5&rft.issue=5&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=ENVIRON.+MUTAGENESIS.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - mutagenicity testing ER - TY - JOUR T1 - Importance of secondary structure in the signal sequence for protein secretion. AN - 13693012; 570032 AB - Mutant E. coli strains in which export of the LamB protein (coded for by the lamB gene) to the outer membrane of the cell is prevented have been described previously. One of these mutant strains contains a small (12-base pair) deletion mutation within the region of the lambB gene that codes for the NH sub(2)-terminal signal sequence. In this mutant strain, export but not synthesis of the LamB protein is blocked. The authors have isolated pseudorevertants that restore export of functional LamB protein to the outer membrane. DNA sequence analysis showed that two of the revertants contain a point mutation in addition to the original deletion. These point mutations lead to amino acid substitutions within the signal sequence. Their results indicate that these secondary mutations efficiently suppress the export defect caused by the deletion mutation. Analysis of the secondary structure of the wild-type, mutant, and pseudorevertant LamB signal sequences suggests that the secondary mutations restore export by allowing the foramtion of a stable alpha -helical conformation in the central, hydrophobic region of the signal sequence. JF - Proceedings of the National Academy of Sciences, USA AU - Emr, S D AU - Silhavy, T J AD - Cancer Biol. Program, NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 4599 EP - 4603 VL - 80 IS - 15 SN - 0027-8424, 0027-8424 KW - secretion KW - role KW - lamB protein KW - Escherichia coli KW - outer membranes KW - porins KW - secondary structure KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 1: Biological Membranes (till 1993) KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13693012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Importance+of+secondary+structure+in+the+signal+sequence+for+protein+secretion.&rft.au=Emr%2C+S+D%3BSilhavy%2C+T+J&rft.aulast=Emr&rft.aufirst=S&rft.date=1983-01-01&rft.volume=80&rft.issue=15&rft.spage=4599&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; porins; secondary structure; outer membranes ER - TY - JOUR T1 - Partition of unit-copy miniplasmids to daughter cells. I. P1 and F miniplasmids contain discrete, interchangeable sequences sufficient to promote equipartition. AN - 13692808; 572851 AB - Hybrids formed by insertion of the plasmid maintenance regions of P1 or F into a lambda Delta att vector form stable unit-copy plasmids in their E. coli host. They must therefore both be substrates for an accurate cellular partition apparatus that ensures that all daughter cells inherit a plasmid copy. Analysis of deletion mutants of both types of hybrid showed that, although the P1 and F plasmid maintenance regions differ in sequence and specificity, they are similar in general organization. Each contains an approximately 3 x 10 super(3) base-pair region that is essential for replication (rep)) and an adjacent but separable 3 x 10 super(3) base-pair region that is essential for the stability of plasmid maintenance (par)). Each par region is thought to specify the recognition of the plasmid as a substrate for equipartition. The deletion mutants provide sources of isolated rep and par sequences from both P1 and F DNA. These elements were then used to construct composite plasmids with novel combinations and arrangements of rep and par sequences. Heterologous construction containing P1 rep and F par or F rep and P1 par sequences were maintained faithfully. The authors conclude that par regions are both necessary and sufficient to promote equipartition of replicating plasmid DNA. JF - Journal of Molecular Biology AU - Austin, S AU - Abeles, A AD - Lab. Mol. Biol., LBI-Basic Res. Program, NCI Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 353 EP - 372 VL - 169 IS - 2 SN - 0022-2836, 0022-2836 KW - partition KW - analysis KW - F factors KW - plasmid P1 KW - host systems KW - role KW - par gene KW - conjugation KW - Genetics Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - phage P1 KW - genes KW - nucleotide sequence KW - cell division KW - Escherichia coli KW - plasmids KW - prophages KW - J 02750:Phage-host interactions KW - V 22070:Phage-host interactions including lysogeny & transduction KW - G 07201:F/R PLASMIDS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13692808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Partition+of+unit-copy+miniplasmids+to+daughter+cells.+I.+P1+and+F+miniplasmids+contain+discrete%2C+interchangeable+sequences+sufficient+to+promote+equipartition.&rft.au=Austin%2C+S%3BAbeles%2C+A&rft.aulast=Austin&rft.aufirst=S&rft.date=1983-01-01&rft.volume=169&rft.issue=2&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; phage P1; cell division; prophages; nucleotide sequence; plasmids; genes ER - TY - JOUR T1 - Partition of unit-copy miniplasmids to daughter cells. II. The partition region of miniplasmid P1 encodes an essential protein and a centromere-like site at which it acts. AN - 13691313; 572869 AB - The stable maintenance of the unit-copy lambda -P1 : 5R miniplasmid is dependent on adjacent but separable replication (rep ) and partition (par ) regions of DNA derived from its P1 plasmid parent. The par region consists of an approximately 2 multiplied by 5 x 10 super(3) base-pair (kb) segment of DNA of which the terminal kb contains the plasmid incompatibility determinant incB. Two of the 14 lambda -P1:5R partition defective point mutants isolated are amber (nonsense) mutants, showing that a plasmid-encoded protein is essential for proper partition. Deletion analysis showed that the incB sequence is essential in cis to the plasmid in order that the plasmid be receptive to the par) protein. Thus incB appears to be the target site for par protein activity. The authors propose that the protein binds to incB, forming a complex that is recognized as a substrate for the cellular partition apparatus. The ability of a cloned incB sequence to compete for the par protein or for the cellular partition apparatus accounts for its activity as an incompatibility determinant. The existence of a plasmid-encoded par protein suggests a specific model for equipartition. JF - Journal of Molecular Biology AU - Austin, S AU - Abeles, A AD - Lab. Mol. Biol., LBI-Basic Res. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 373 EP - 387 VL - 169 IS - 2 SN - 0022-2836, 0022-2836 KW - partition KW - role KW - plasmid p1 KW - conjugation KW - host systems KW - par gene KW - Genetics Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - phage P1 KW - genes KW - Escherichia coli KW - plasmids KW - prophages KW - cell division KW - proteins KW - recurrent infection KW - J 02750:Phage-host interactions KW - G 07200:P PLASMIDS KW - V 22070:Phage-host interactions including lysogeny & transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13691313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Partition+of+unit-copy+miniplasmids+to+daughter+cells.+II.+The+partition+region+of+miniplasmid+P1+encodes+an+essential+protein+and+a+centromere-like+site+at+which+it+acts.&rft.au=Austin%2C+S%3BAbeles%2C+A&rft.aulast=Austin&rft.aufirst=S&rft.date=1983-01-01&rft.volume=169&rft.issue=2&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; phage P1; cell division; prophages; proteins; plasmids; genes; recurrent infection ER - TY - JOUR T1 - Amino acid sequence of human respiratory syncytial virus nucleocapsid protein. AN - 13687936; 564575 AB - Amino acid sequence of the human respiratory syncytial (RS) virus nucleocapsid (NC) protein, deduced from the DNA sequence of a recombinant plasmid, is presented. the cDNA plasmid (pRSB11) has 1412 bp of RS viral NC sequence and lacks six nucleotides of the 5' end of mRNA. There is a single long open reading frame encoding 467 amino acids. This 51540 dal protein is rich in basic amino acids and has no homologies with other known viral capsid proteins. JF - Nucleic Acids Research AU - Elango, N AU - Venkatesan, S AD - Lab. Infect. Dis., NIAID, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 5941 EP - 5951 VL - 11 IS - 17 SN - 0305-1048, 0305-1048 KW - amino acid sequence KW - cDNA KW - capsid protein KW - genes KW - nucleotide sequence KW - respiratory syncytial virus KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - V 22032:Viral proteins KW - G 07313:Viruses KW - N 14540:Structure, sequence & physical properties KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13687936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Amino+acid+sequence+of+human+respiratory+syncytial+virus+nucleocapsid+protein.&rft.au=Elango%2C+N%3BVenkatesan%2C+S&rft.aulast=Elango&rft.aufirst=N&rft.date=1983-01-01&rft.volume=11&rft.issue=17&rft.spage=5941&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - nucleotide sequence; capsid protein; amino acid sequence; genes ER - TY - JOUR T1 - Alcohol and coronary heart disease in Puerto Rico. AN - 13681766; 561468 AB - The relationship of alcohol consumption, measured in 1965-1968 by the 24-hour recall method, to incident coronary heart disease morbidity at eight years and mortality at 12 years of follow-up was investigated in a cohort of 9150 Puerto Rican males 35-79 years of age. JF - American Journal of Epidemiology AU - Kittner, S J AU - Garcia-Palmieri, R AU - Costas, R Jr AU - Cruz-Vidal, M AU - Abbott, R D AU - Havlik, R J AD - Epidemiol. Biomet. Program, NHLBI, Fed. Build., Room 300, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 538 EP - 550 VL - 117 IS - 5 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts KW - alcohol KW - mortality KW - cardiovascular diseases KW - epidemiology KW - morbidity KW - H SE4.26:DRUGS AND ALCOHOL KW - H SM3.8.4:DRUGS AND ALCOHOL KW - H SM10.22:CARDIOVASCULAR SYSTEM DISEASES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13681766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Alcohol+and+coronary+heart+disease+in+Puerto+Rico.&rft.au=Kittner%2C+S+J%3BGarcia-Palmieri%2C+R%3BCostas%2C+R+Jr%3BCruz-Vidal%2C+M%3BAbbott%2C+R+D%3BHavlik%2C+R+J&rft.aulast=Kittner&rft.aufirst=S&rft.date=1983-01-01&rft.volume=117&rft.issue=5&rft.spage=538&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - cardiovascular diseases; mortality; morbidity; alcohol; epidemiology ER - TY - JOUR T1 - Carcinogenesis in F344 rats by N-nitrosomethyl-n-propylamine derivatives. AN - 13677815; 553399 AB - The carcinogenicity of N-nitrosomethyl-n-propylamine and five of its derivatives, including N-nitrosomethyl-n-butylamine, was compared by oral administration of the compounds to inbred F344 rats. N-Nitromethyl-n-propylamine and N-nitrosomethyl-n-butylamine given in drinking water induced tumors of the upper gastrointestinal tract, mainly carcinomas of the esophagus, and appeared to be of comparable potency. N-Nitrosomethyl(2-hydroxypropyl)amine also mainly induced esophageal carcinomas (100% incidence) and lung tumors, whereas N-nitrosomethyl(2,8-dihydroxypropyl)amino manly induced nasal cavitiy tumors and gave rise to a high incidence of esophageal tumors; however, it appeared to be less potent than the monohydroxy compound. JF - Journal of the National Cancer Institute AU - Lijinsky, W AU - Reuber, MD AU - Saavedra, JE AU - Singer, G M AD - Chem. Carcinogenesis Program, NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 959 EP - 964 VL - 70 IS - 5 SN - 0027-8874, 0027-8874 KW - derivatives KW - comparison KW - N-nitrosomethyl-n-propylamine KW - rats KW - Toxicology Abstracts KW - gastrointestinal tract KW - carcinogenicity KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13677815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Carcinogenesis+in+F344+rats+by+N-nitrosomethyl-n-propylamine+derivatives.&rft.au=Lijinsky%2C+W%3BReuber%2C+MD%3BSaavedra%2C+JE%3BSinger%2C+G+M&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1983-01-01&rft.volume=70&rft.issue=5&rft.spage=959&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity; gastrointestinal tract ER - TY - JOUR T1 - Altered incidences of hepatic and hemopoietic neoplasms in F344 rats fed sodium nitrite. AN - 13670940; 553814 AB - Three groups of 24 male, and three groups of 24 female F344 rats were fed sodium nitrite for 2 years. There was little difference in survival between the treated groups and the controls. The incidence of liver neoplasms, which were carcinomas and neoplastic nodules, in the two groups of females treated with sodium nitrite in feed was significantly higher than in the controls, but there was no significant difference in the males. The incidence of monocytic leukemia for each of the nitrite-treated groups was always lower than that for the matching untreated control groups, with the difference attaining or approaching significance in five of the six cases. JF - Carcinogenesis AU - Lijinsky, W AU - Kovatch, R AU - Riggs, C W AD - LBI-Basic Res. Program, Chem. Carcinog. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 1189 EP - 1191 VL - 4 IS - 9 SN - 0143-3334, 0143-3334 KW - induction KW - sodium nitrite KW - rats KW - Toxicology Abstracts KW - sex differences KW - liver KW - neoplasia KW - X 24112:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13670940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Altered+incidences+of+hepatic+and+hemopoietic+neoplasms+in+F344+rats+fed+sodium+nitrite.&rft.au=Lijinsky%2C+W%3BKovatch%2C+R%3BRiggs%2C+C+W&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1983-01-01&rft.volume=4&rft.issue=9&rft.spage=1189&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - neoplasia; liver; sex differences ER - TY - JOUR T1 - Mechanisms of protein localization. AN - 13665924; 542874 JF - Microbiological reviews. Baltimore AU - Silhavy, T J AU - Benson, SA AU - Emr, S D AD - Lab. Genet. & Recombinant DNA, LBI-Basic Res. Prog., NCI-Frederick Cancer Res. Fac., Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 313 EP - 344 VL - 47 IS - 3 SN - 0146-0749, 0146-0749 KW - localization KW - kinetics KW - genetic analysis KW - Escherichia coli KW - eukaryotes KW - membrane proteins KW - organelles KW - proteins KW - reviews KW - Biochemistry Abstracts 1: Biological Membranes (till 1993); Microbiology Abstracts B: Bacteriology KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13665924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiological+reviews.+Baltimore&rft.atitle=Mechanisms+of+protein+localization.&rft.au=Silhavy%2C+T+J%3BBenson%2C+SA%3BEmr%2C+S+D&rft.aulast=Silhavy&rft.aufirst=T&rft.date=1983-01-01&rft.volume=47&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Microbiological+reviews.+Baltimore&rft.issn=01460749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; proteins; organelles; reviews; eukaryotes; membrane proteins ER - TY - JOUR T1 - Biochemical prophage induction assay: A rapid test for antitumor agents that interact with DNA. AN - 13660344; 540445 AB - A biochemical (colorimetric) assay of bacteriophage lambda induction was utilized in the detection, identification, and purification of DNA-interacting natural products with potential antitumor activity. A set of 142 standard antibiotics, composed principally of natural products with established antitumor activity and/or defined mechanisms of action, was tested in the assay. As expected, most inducers were direct inhibitors of DNA synthesis. A few other types of inducer, with probable indirect effects on DNA synthesis, were found after prolonged incubation: one class of RNA synthesis inhibitor, a dihydrofolate reductase inhibitor; and two inhibitors of bacterial cell wall synthesis. The biochemical induction assay was semiautomated for use as a prescreen in the search for novel antitumor agents in 10,724 actinomycete fermentation broths. Approximately 1% of the cultures produced compounds that were active in the assay; some appear to be novel. None required metabolic activation for inducing activity. JF - Cancer Research AU - Elespuru, R K AU - White, R J AD - Biol. Carcin. Program, NCI-Frederick Cancer Res. Fac., Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 2819 EP - 2830 VL - 43 IS - 6 SN - 0008-5472, 0008-5472 KW - Health & Safety Science Abstracts KW - laboratory methods KW - purification KW - bioassays KW - cancer KW - H SM10.21:CANCER UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13660344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Biochemical+prophage+induction+assay%3A+A+rapid+test+for+antitumor+agents+that+interact+with+DNA.&rft.au=Elespuru%2C+R+K%3BWhite%2C+R+J&rft.aulast=Elespuru&rft.aufirst=R&rft.date=1983-01-01&rft.volume=43&rft.issue=6&rft.spage=2819&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - cancer; bioassays; purification; laboratory methods ER - TY - JOUR T1 - In vitro radiation and chemotherapy sensitivity of established cell lines of human small cell lung cancer and its large cell morphological variants. AN - 13659245; 540429 AB - The in vivo response to radiation and chemotherapeutic drugs of cell lines established from 7 patients with small cell (SC) lung cancer were tested using a soft agarose clonogenic assay. Five cell lines retained the typical morphological and biochemical amine precursor uptake decarboxylation characteristics of SC, while two cell lines had undergone "transformation" to large cell (LC) morphological variants with loss of amine precursor uptake decarboxylation cell characteristics of SC. JF - Cancer Research AU - Carney, D N AU - Mitchell, J B AU - Kinsella, T J AD - NCI-Navy Med. Oncol. Branch, Natl. Cancer Inst., Bethesda, MD, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 2806 EP - 2811 VL - 43 IS - 6 SN - 0008-5472, 0008-5472 KW - dose response effects KW - Pollution Abstracts; Health & Safety Science Abstracts KW - radiation KW - morphology KW - cytology KW - chemical treatment KW - cancer KW - H SM10.21:CANCER KW - P 6000:TOXICOLOGY AND HEALTH KW - H SM7.1:BASIC APPROACHES, CONCEPTS, AND THEORY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13659245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=In+vitro+radiation+and+chemotherapy+sensitivity+of+established+cell+lines+of+human+small+cell+lung+cancer+and+its+large+cell+morphological+variants.&rft.au=Carney%2C+D+N%3BMitchell%2C+J+B%3BKinsella%2C+T+J&rft.aulast=Carney&rft.aufirst=D&rft.date=1983-01-01&rft.volume=43&rft.issue=6&rft.spage=2806&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - morphology; cytology; radiation; cancer; chemical treatment ER - TY - JOUR T1 - DNA breakage by methyl methanesulfonate and its repair in brain and liver cells cultured from fetal rat and mouse. AN - 13644609; 518393 AB - DNA strand breakage and repair following methyl methanesulfonate (MMS) treatment of primary cell cultures from 14-day fetal Sprague-Dawley rat brain and liver and 12-day fetal C57BL/6 mouse brain and liver, were studied using alkaline sucrose density gradient analysis. The extent of initial damage in fetal rat and fetal mouse cells was comparable. Fetal mouse brain and liver and rat liver showed nearly complete repair 24 h after treatment. However, fetal rat brain cells showed comparatively little repair after 24 h. The possible significance of a repair deficit in cultured rat fetal brain cells and the striking neurogenic organotropism of transplacentally administered direct-acting alkylating agents in the rat is discussed. JF - Chemico-Biological Interactions AU - Chen, B P AU - Berman, J J AU - Ching, W-M AU - Rice, J M AD - Lab. Comp. Carcinog., NCI, Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 63 EP - 77 VL - 44 IS - 1-2 SN - 0009-2797, 0009-2797 KW - induction KW - breaks KW - methylmethanesulfonate KW - rats KW - mice KW - Toxicology Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - DNA repair KW - DNA KW - liver KW - brain KW - N 14630:Chemical reactions & interactions, including effects of radiation KW - X 24155:Biochemistry KW - N 14652:DNA repair KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13644609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-Biological+Interactions&rft.atitle=DNA+breakage+by+methyl+methanesulfonate+and+its+repair+in+brain+and+liver+cells+cultured+from+fetal+rat+and+mouse.&rft.au=Chen%2C+B+P%3BBerman%2C+J+J%3BChing%2C+W-M%3BRice%2C+J+M&rft.aulast=Chen&rft.aufirst=B&rft.date=1983-01-01&rft.volume=44&rft.issue=1-2&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Chemico-Biological+Interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - DNA; DNA repair; liver; brain ER - TY - JOUR T1 - A rapid, large scale purification procedure for gibbon interleukin 2. AN - 13641298; 530346 AB - Interleukin 2 (IL 2) was purified from the conditioned medium of a gibbon T cell line, MLA144, which releases IL 2 constitutively. The IL 2 was obtained free of contaminating proteins by a simple process consisting of an initial batch purification on trimethylsilyl-controlled pore glass followed by reversed phase high pressure liquid chromatography. Three molecular forms had apparent m.w. of 16,000 but different isoelectric points of 5.9, 6.3, and 6.7. One molecular form had an apparent m.w. of 15,000 and an isolectric point of 7.2. The most abundant form of IL 2 had an apparent m.w. of 16,000 and an isoelectric point of 6.3. The purified IL 2 supported the growth of IL 2-dependent lymphocytes to a greater extent than did the same level of crude IL 2-containing MLA144 conditioned medium. The ability to purify large amounts of IL 2 by a rapid and efficient procedure will be of great help in both biochemical and immunologic studies of this lymphokine. JF - Journal of Immunology AU - Henderson, LE AU - Hewetson, J F AU - Hopkins, RF III AU - Sowder, R C AU - Neubauer, R H AU - Rabin, H AD - LBI-Basic Res. Prog., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 810 EP - 815 VL - 131 IS - 2 SN - 0022-1767, 0022-1767 KW - Primates KW - cell lines KW - characterization KW - interleukin 2 KW - lymphocytes T KW - purification KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13641298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=A+rapid%2C+large+scale+purification+procedure+for+gibbon+interleukin+2.&rft.au=Henderson%2C+LE%3BHewetson%2C+J+F%3BHopkins%2C+RF+III%3BSowder%2C+R+C%3BNeubauer%2C+R+H%3BRabin%2C+H&rft.aulast=Henderson&rft.aufirst=LE&rft.date=1983-01-01&rft.volume=131&rft.issue=2&rft.spage=810&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Purification and characterization of guinea pig antithrombin III. AN - 13626085; 508058 AB - Antithrombin III (AT III) is a serine esterase inhibitor which regulates the activity of a number of coagulation factors. In this report, a three-step procedure for the purification of guinea pig AT III is described. This method, which involves affinity chromatography with heparin-Sepharose, ion exchange chromatography using DEAE-Sepharose, and Sephadex G-100 gel chromatography, results in purified, functionally active AT III with a 39% yield. The potential role of this molecule in the regulation of lymphocyte activation is discussed. JF - Preparative Biochemistry and Biotechnology AU - Clement, L T AD - Lab. Immunol., NIAID, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 1 EP - 20 VL - 13 IS - 1 SN - 0032-7484, 0032-7484 KW - antithrombin III KW - characterization KW - guinea-pigs KW - purification KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13626085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preparative+Biochemistry+and+Biotechnology&rft.atitle=Purification+and+characterization+of+guinea+pig+antithrombin+III.&rft.au=Clement%2C+L+T&rft.aulast=Clement&rft.aufirst=L&rft.date=1983-01-01&rft.volume=13&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Preparative+Biochemistry+and+Biotechnology&rft.issn=00327484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Human plasma proapoA-I: Isolation and amino-terminal sequence. AN - 13622634; 507382 AB - Human apoA-I is synthesized as preproapo-A-I, a 267 amino acdi co-translational proteolytic cleavage into proapoA-I. ProapoA-I is secreted from the cell and was isolated from thoracic duct lymph in the apo-A-I sub(dl isoform position. The amino-terminal sequence of proapoA-I siolated from human lymph revealed the presence of 6 additional amino acids, Arg-His-Phe-Trp-Gln-Gln, on the amino-terminal end of apoA-I consistent with the proapoA-I sequence determined by nucleic acid sequence analysis of cloned apoA-I. JF - Biochemical and Biophysical Research Communications AU - Brewer, HB Jr AU - Fairwell, T AU - Kay, L AU - Meng, M AU - Ronan, R AU - Law, S AU - Light, JA AD - Mol. Disease Branch, NHLBI, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 626 EP - 632 VL - 113 IS - 2 SN - 0006-291X, 0006-291X KW - N-termunus KW - amino acid sequence KW - isolation KW - man KW - plasma KW - proapoliproten-I KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13622634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Human+plasma+proapoA-I%3A+Isolation+and+amino-terminal+sequence.&rft.au=Brewer%2C+HB+Jr%3BFairwell%2C+T%3BKay%2C+L%3BMeng%2C+M%3BRonan%2C+R%3BLaw%2C+S%3BLight%2C+JA&rft.aulast=Brewer&rft.aufirst=HB&rft.date=1983-01-01&rft.volume=113&rft.issue=2&rft.spage=626&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Regulation and properties of an NADP super(+) oxidoreductase which functions as a gamma -hydroxybutyrate dehydrogenase. AN - 13621152; 503800 AB - A number of naturally occurring biological intermediates have been found to inhibit competitively the activity of a highly purified NADP super(+)-dependent oxidoreductase which catalyzes the simultaneous oxidation of gamma -hydroxybutyrate to succinic semialdehyde, and the reduction of D-glucuronate to L-gulonate. Of the inhibitors studied, those with the lowest K sub(i) are the alpha -keto analogues of the branched chain or aromatic amino acids. The V sub(max) and K sub(m) for this enzyme are affected by pH; consequently, changes in substrate concentration can markedly alter the pH optimum. The enzyme has been found to be inhibited by reducing agents such as dithiothreitol and mercaptoethanol, protected against this inhibition by oxidizing agents such as oxidized glutathione or H sub(2)O sub(2), and finally, protected against heat inactivation by the presence of either NADP super(+) or NADPH. JF - Journal of Neurochemistry AU - Kaufman, EE AU - Relkin, N AU - Nelson, T AD - Lab. Cerebral Metabolism, NIMH, 9000 Rockville Pike, Build. 36, Rm. 1 A-27, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 1639 EP - 1646 VL - 40 IS - 6 SN - 0022-3042, 0022-3042 KW - gamma -hydroxybutyric acid KW - glucuronate reductase KW - kinetics KW - oxidation KW - regulation KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - N3 11070:Neurochemistry and cellular biology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13621152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Regulation+and+properties+of+an+NADP+super%28%2B%29+oxidoreductase+which+functions+as+a+gamma+-hydroxybutyrate+dehydrogenase.&rft.au=Kaufman%2C+EE%3BRelkin%2C+N%3BNelson%2C+T&rft.aulast=Kaufman&rft.aufirst=EE&rft.date=1983-01-01&rft.volume=40&rft.issue=6&rft.spage=1639&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Determination of some molecular parameters of tyrosine hydroxylase from rat adrenal, rat striatum, and human pheochromocytoma. AN - 13620307; 503732 AB - The molecular parameters of typrosine hydroxylase (EC 1.14 16.2) from rat adrenal, rat striatum, and human pheochromocytoma were determined by combined gel filtration and sucrose gradient ultracentrifugation. The enzyme from rat adrenal has a calculated molecular weight of 228,000, a Stokes radius of 60.9 angstrom, a sedimentation coefficient of 9.10S, and a frictional ratio of 1.39. The enzyme from rat striatum has a calculated molecular weight of 210,000, a Stokes radius of 54.3 angstrom, a sedimentation coefficient of 9.38S, and a frictional ration of 1.28. Tyrosine hydroxylase from human pheochromocytoma tissue has a calculated molecular weight of 255,000, a Stokes radius of 68.2 angstrom, a ssedimentation coefficient of 9.08S, and a firctional ratio of 1.50. These results indicate that the tyrosine hydroxylases from central and peripheral tissue in the rat are quite similar although the human enzyme appears to be significantly larger. JF - Journal of Neurochemistry AU - Rosenberg, R C AU - Lovenberg, W AD - Sect. Biochem. Pharmacol., Hypertension-Endocrine Branch, NHLBI, Bethesda, 20205 MD, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 1529 EP - 1533 VL - 40 IS - 6 SN - 0022-3042, 0022-3042 KW - adrenal gland KW - comparison KW - man KW - pheochromocytoma KW - physicochemical properties KW - rats KW - striate cortex KW - sympathetic nervous system KW - tyrosine 3-monooxygenase KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - N3 11070:Neurochemistry and cellular biology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13620307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Determination+of+some+molecular+parameters+of+tyrosine+hydroxylase+from+rat+adrenal%2C+rat+striatum%2C+and+human+pheochromocytoma.&rft.au=Rosenberg%2C+R+C%3BLovenberg%2C+W&rft.aulast=Rosenberg&rft.aufirst=R&rft.date=1983-01-01&rft.volume=40&rft.issue=6&rft.spage=1529&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - sympathetic nervous system; striate cortex; man ER - TY - JOUR T1 - Total solid-phase synthesis, purification, and characterization of human parathyroid hormone-(1-84). AN - 13616146; 492870 JF - Biochemistry (Washington) AU - Fairwell, T AU - Hospattankar, A V AU - Ronan, R AU - Brewer, HB Jr AU - Chang, J K AU - Shimizu, M AU - Zitzner, L AU - Arnaud, C D AD - Mol. Disease Branch, NHLBI, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 2691 EP - 2697 VL - 22 IS - 11 SN - 0006-2960, 0006-2960 KW - man KW - parathyroid hormone KW - peptide synthesis KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13616146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Total+solid-phase+synthesis%2C+purification%2C+and+characterization+of+human+parathyroid+hormone-%281-84%29.&rft.au=Fairwell%2C+T%3BHospattankar%2C+A+V%3BRonan%2C+R%3BBrewer%2C+HB+Jr%3BChang%2C+J+K%3BShimizu%2C+M%3BZitzner%2C+L%3BArnaud%2C+C+D&rft.aulast=Fairwell&rft.aufirst=T&rft.date=1983-01-01&rft.volume=22&rft.issue=11&rft.spage=2691&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Reductive destruction of hydrazines as an approach to hazard control. AN - 13611080; 502534 AB - Hydrazine and 14 of its mono- and disubstituted alkyl, aryl, and acyl derivatives were quantitatively destroyed by using either of two nickel-based catalytic reductive procedures. Small volumes of solutions containing hydrazines were made alkaline and treated with aluminum-nickel powder; large volumes were treated with preformed Raney nickel with or without an exogenous hydrogen source. No interference was discovered except from acetone. These procedures appear to provide a reliable, efficient, one-step approach to conversion of potentially carcinogenic hydrazines to innocuous products in laboratory wastes or in the environment. JF - Environmental Science & Technology AU - Lunn, G AU - Sansone, E B AU - Keefer, L K AD - Environ. Cont. & Res. Progr., NCI--Frederick Cancer Res. Fac., Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 240 EP - 243 VL - 17 IS - 4 SN - 0013-936X, 0013-936X KW - hydrazine KW - Ecology Abstracts KW - chemical pollution KW - pollution control KW - D 04804:Pollution control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13611080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Reductive+destruction+of+hydrazines+as+an+approach+to+hazard+control.&rft.au=Lunn%2C+G%3BSansone%2C+E+B%3BKeefer%2C+L+K&rft.aulast=Lunn&rft.aufirst=G&rft.date=1983-01-01&rft.volume=17&rft.issue=4&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - chemical pollution; pollution control ER - TY - JOUR T1 - Phenylethanolamine N-methyltransferase: Notes on its purification from bovine adrenal medulla and separation from protein carboxymethyltransferase. AN - 13599471; 488536 AB - Standard procedures for the purification of phenylethanolamine N-methyltransferase were modified by the addition of an affinity chromatography step utilizaing immobilized S-adenosyl-L-homocysteine and by use of preparative isolelectric focusing. Enzyme derived from bovine adrenal medullae was bound to S-adenosyl-L-homocysteine agarose, and could be eluted with 0.1 M NaCl. Concentrations of S-adenosyl-L-methionine as high as 10 mM were ineffective in eluting the enzyme. Preparative isoelectric focusing of bovine phenylethanolamine N-methyltransferase showed a single peak with the pI = 4.95. JF - Biochemical and Biophysical Research Communications AU - Hurst, J H AU - Guchhait, R B AU - Billingsley, M L AU - Stolk, J M AU - Lovenberg, W AD - Natl. Inst. Health, NHLBI, Build. 10, Room 7N262, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 1061 EP - 1068 VL - 112 IS - 3 SN - 0006-291X, 0006-291X KW - adrenal medulla KW - cattle KW - noradrenalin N-methyltransferase KW - purification KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13599471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Phenylethanolamine+N-methyltransferase%3A+Notes+on+its+purification+from+bovine+adrenal+medulla+and+separation+from+protein+carboxymethyltransferase.&rft.au=Hurst%2C+J+H%3BGuchhait%2C+R+B%3BBillingsley%2C+M+L%3BStolk%2C+J+M%3BLovenberg%2C+W&rft.aulast=Hurst&rft.aufirst=J&rft.date=1983-01-01&rft.volume=112&rft.issue=3&rft.spage=1061&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Analysis of human urine for mutagens associated with carcinoma of the bilharzial bladder by the Ames Salmonella plate assay. Interpretation employing quantitation of viable lawn bacteria. AN - 13598221; 485760 AB - The Ames Salmonella plate assay was employed to test urine samples from bladder cancer patients and controls living in Egypt for the presence of chemical mutagens. Urine from five groups of Egyptian adults were tested, including individuals with: (1) neither bilharziasis nor bladder cancer, (2) urinary bilharziasis and normal urinary cytology, (3) urinary bilharziasis and atypical urinary cytology, (4) carcinoma of the bilharzial bladder, and (5) bladder cancer without bilharziasis. Plates treated with histidine dependent bacteria, S-9 mix, beta-glucuronidases and 0.3 ml sterile urine from all five groups yielded 50 to 150 percent more colonies than plates treated with saline instead of urine. A procedure for quantitating viable bacteria in the lawn was devised which demonstrated that the increase in colonies on urine treated plates could be attributed to increased numbers of viable bacteria in the bacterial lawn on those plates. There was, therefore, no convincing evidence for the presence of mutagenic substances in these urine samples. JF - Cancer AU - Everson, R B AU - Gad-El-Mawla, N M AU - Attia, MAM AU - Chevlen, E M AU - Thorgeirsson, S S AU - Alexander, LA AU - Flack, P M AU - Staiano, N AU - Ziegler, J L AD - Build. 101, Rm. A356, P.O. Box 12233, NIEHS, Research Triangle Park, NC 27709, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 371 EP - 377 VL - 51 IS - 3 SN - 0008-543X, 0008-543X KW - mutagens KW - association KW - Genetics Abstracts; Toxicology Abstracts KW - schistosomiasis KW - Ames test KW - urine KW - urinary bladder KW - man KW - carcinoma KW - G 07220:General theory/testing systems KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13598221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Analysis+of+human+urine+for+mutagens+associated+with+carcinoma+of+the+bilharzial+bladder+by+the+Ames+Salmonella+plate+assay.+Interpretation+employing+quantitation+of+viable+lawn+bacteria.&rft.au=Everson%2C+R+B%3BGad-El-Mawla%2C+N+M%3BAttia%2C+MAM%3BChevlen%2C+E+M%3BThorgeirsson%2C+S+S%3BAlexander%2C+LA%3BFlack%2C+P+M%3BStaiano%2C+N%3BZiegler%2C+J+L&rft.aulast=Everson&rft.aufirst=R&rft.date=1983-01-01&rft.volume=51&rft.issue=3&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Ames test; urine; carcinoma; urinary bladder; man; schistosomiasis ER - TY - JOUR T1 - Comparison of the effects of tropomyosin and troponin-tropomyosin on the binding of myosin subfragment 1 to actin. AN - 13597332; 489554 AB - The effect of tropomyosin alone on the binding of myosin subfragment 1 (S-1) to actin was compared to that of troponin-tropomyosin, with and without Ca super(2+). Over a range of ionic strength and with different ligands (adenyl-5'-yl imidodiphosphate, pyrophosphate, and adenosine 5'-diphosphate), tropomyosin confers slight cooperativity to the binding of S-1 to actin. In the presence of Ca super(2+), troponin dose not affect the cooperative action of tropomyosin alone. In addition, troponin-tropomyosin and tropomyosin alone are also identical in their ability to strengthen the binding of S-1 multiplied by ligand to actin 3-fold and the binding of S-1 alone to actin 7-fold, at high levels of saturation of the actin with S-1. Although troponin does not significantly affect the cooperative action of tropomyosin alone in the presence of Ca super(2+), it does markedly enhance the cooperativity in the binding of S-1 to actin in the absence of Ca super(2+). JF - Biochemistry (Washington) AU - Williams, D L AU - Greene, LE AD - Lab. Cell Biol., NHLBI, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 2770 EP - 2774 VL - 22 IS - 11 SN - 0006-2960, 0006-2960 KW - actin KW - binding KW - effects on KW - myosin KW - rabbits KW - skeletal muscle KW - subfragment-1 KW - tropomyosin KW - troponin KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13597332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Comparison+of+the+effects+of+tropomyosin+and+troponin-tropomyosin+on+the+binding+of+myosin+subfragment+1+to+actin.&rft.au=Williams%2C+D+L%3BGreene%2C+LE&rft.aulast=Williams&rft.aufirst=D&rft.date=1983-01-01&rft.volume=22&rft.issue=11&rft.spage=2770&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Chronic toxicity studies of vinyl acetate in fischer rats. AN - 13596190; 489002 AB - A chronic toxicity test was carried out in groups of 20 male and female F344 rats with vinyl acetate dissolved in drinking water at two concentrations, 2500 and 1000 mg/liter. Treatment lasted for 2 years and did not lead to early death of the animals compared with untreated controls. The incidence of most types of neoplasm was similar in the treated and control groups. However, six females receiving the high dose of vinyl acetate had adenoma or carcinoma of the thyroid and five had carcinoma of the uterus; the latter were not seen in the controls. JF - Toxicology and Applied Pharmacology AU - Lijinsky, W AU - Reuber, MD AD - Basic Res. Program-LBI, Chem. Carcinog. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 45 EP - 53 VL - 68 IS - 1 SN - 0041-008X, 0041-008X KW - toxicity KW - vinyl acetate KW - rats KW - Toxicology Abstracts KW - carcinogenicity KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13596190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Chronic+toxicity+studies+of+vinyl+acetate+in+fischer+rats.&rft.au=Lijinsky%2C+W%3BReuber%2C+MD&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1983-01-01&rft.volume=68&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity ER - TY - JOUR T1 - The protein phosphatases involved in cellular regulation. 4. Classification of two homogeneous myosin light chain phosphatases from smooth muscle as protein phosphatase-2A sub(1) and 2C, and a homogeneous protein phosphatase from reticulocytes active on protein synthesis initiation factor eIF-2 as protein phosphatase-2A sub(2). AN - 13595818; 489633 AB - Two homogeneous protein phosphatases, termed "smooth muscle phosphatase-I" and "smooth muscle phosphatase-II", isolated from turkey gizzard as enzymes active against the 20-kDa light chain of smooth muscle myosin, and a third homogeneous protein phosphatase from rabbit reticulocytes, purified as an enzyme active against protein synthesis initiation factor eIF-2, were classified using the criteria defined by Ingebritsen and Cohen. All three enzymes were type-2 protein phosphatases based on their specificity for the alpha -subunit of phosphorylase kinase and insensitivity to inhibitor-1 and inhibitor-2. The substrate specificities of smooth muscle phosphatase-I and the eIF-2 phosphatase were similar to the catalytic subunit of protein phosphatase-2A. Smooth muscle phosphatase-I could be designated as protein phosphatase-2A sub(1) and eIF-2 phosphatase as protein phosphatase-2A sub(2) on the basis of their subunit compositions. The substrate specificity, dependence of activity on Mg super(2+) and subunit composition of smooth muscle phosphatase-II allowed its assignment as protein phosphatase-2C. JF - European Journal of Biochemistry AU - Pato, MD AU - Adelstein, R S AU - Crouch, D AU - Safer, B AU - Ingebritsen, T S AU - Cohen, P AD - Lab. Mol. Cardiol. & Mol. Hematol., NHLBI, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 283 EP - 287 VL - 132 IS - 2 SN - 0014-2956, 0014-2956 KW - characterization KW - gizzard KW - isoenzymes KW - isolation KW - phosphoprotein kinase KW - rabbits KW - reticulocytes KW - turkeys KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13595818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Biochemistry&rft.atitle=The+protein+phosphatases+involved+in+cellular+regulation.+4.+Classification+of+two+homogeneous+myosin+light+chain+phosphatases+from+smooth+muscle+as+protein+phosphatase-2A+sub%281%29+and+2C%2C+and+a+homogeneous+protein+phosphatase+from+reticulocytes+active+on+protein+synthesis+initiation+factor+eIF-2+as+protein+phosphatase-2A+sub%282%29.&rft.au=Pato%2C+MD%3BAdelstein%2C+R+S%3BCrouch%2C+D%3BSafer%2C+B%3BIngebritsen%2C+T+S%3BCohen%2C+P&rft.aulast=Pato&rft.aufirst=MD&rft.date=1983-01-01&rft.volume=132&rft.issue=2&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Biochemistry&rft.issn=00142956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Chemotherapy-induced pulmonary toxicity in mice bearing L1210 leukemia. AN - 13580831; 469403 AB - Fatal pulmonary toxicity can be consistently produced in L1210 leukemia-bearing mice by single therapeutic doses of cyclophosphamide, BCNU, and mitomycin C but not by adriamycin. Lung toxicity is principally determined by an existing tumor burden at the time of drug administration. Thus when any of the four chemotherapeutic agents was given 5 days L1210 transplantation there was no mortality. When chemotherapy was delayed to day 7 after L1210 transplantation for mitomycin C or to day 8 after transplantation for BCNU and cyclophosphamide, more severe pulmonary toxicity was found. It is hypothesized that stasis within the pulmonary capillary circulation, resulting from advanced tumor growth and from drug treatment, may contribute to the development of chemotherapy-related toxicity. JF - Oncology AU - Cohen, M H AU - Matthews, MJ AD - NCI-VA Med. Oncol. Branch, Washington, DC, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 132 EP - 137 VL - 40 IS - 2 KW - toxicity KW - L1210 cells KW - cyclophosphamide KW - mitomycin C KW - carmustine KW - mice KW - Toxicology Abstracts KW - lung KW - X 24112:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13580831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology&rft.atitle=Chemotherapy-induced+pulmonary+toxicity+in+mice+bearing+L1210+leukemia.&rft.au=Cohen%2C+M+H%3BMatthews%2C+MJ&rft.aulast=Cohen&rft.aufirst=M&rft.date=1983-01-01&rft.volume=40&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Oncology&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - lung ER - TY - JOUR T1 - Absence of bisulfite mutagenesis in the lacI gene of Escherichia coli . AN - 13546578; 440000 AB - In view of conflicting reports, the authors decided to test the mutagenicity of bisulfite in the E. coli lacI system. This system permits the detection of amber and ochre mutations at 65 individual sites within the lacI gene. Since the DNA sequence and location of each nonsense mutation have been determined, each mutation can be attributed to a specific base change by a combination of deletion mapping and suppression pattern analysis. Of the 65 possible alterations, 26 can arise by G:C arrow right A:T transitions, thereby providing a substantial number of detectable potential targets for bisulfite mutagenesis. JF - Mutation Research AU - Kunz, BA AU - Glickman, B W AD - Lab. Genet., NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 267 EP - 271 VL - 119 IS - 3-4 SN - 0027-5107, 0027-5107 KW - bisulfite KW - Genetics Abstracts; Toxicology Abstracts KW - Escherichia coli KW - mutagenicity KW - X 24155:Biochemistry KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13546578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Absence+of+bisulfite+mutagenesis+in+the+lacI+gene+of+Escherichia+coli+.&rft.au=Kunz%2C+BA%3BGlickman%2C+B+W&rft.aulast=Kunz&rft.aufirst=BA&rft.date=1983-01-01&rft.volume=119&rft.issue=3-4&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; mutagenicity ER - TY - JOUR T1 - The effect of substituents in the aromatic ring on carcinogenicity of N-nitrosomethylaniline in F344 rats. AN - 13534804; 423441 AB - N-Nitroso-N-methylaniline (NMA) and N-nitroso-N-methyl-4-fluoroaniline (p-F-NMA), both non-mutagenic in Salmonella typhimurium and N-nitroso-N-methyl-4-nitroaniline (p-NO sub(2)-NMA), a potent mutagen, were tested for carcinogenicity in F344 rats. NMA was shown to induce a high level of tumors in the upper gastrointestinal tract, particularly in the esophagus. Male rats treated with NMA died with tumors at a slightly higher rate than females, although the final tumor yield was the same. Most of the rats treated with p-F-NMA also developed tumors of the esophagus, but they died less rapidly than the NMA treated rats, indicating that p-F-NMA is a slightly weaker carcinogen than NMA. JF - Carcinogenesis AU - Kroeger-Koepke, M B AU - Reuber, MD AU - Iype, P T AU - Lijinsky, W AU - Michejda, C J AD - Chem. Carcinogen. Prog., NCI-Frederick Cancer Res. Fac., P.O. Box B, Frederick, MD 21701, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 157 EP - 160 VL - 4 IS - 2 SN - 0143-3334, 0143-3334 KW - derivatives KW - N-nitrosomethylanaline KW - rats KW - Toxicology Abstracts KW - carcinogenicity KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13534804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+effect+of+substituents+in+the+aromatic+ring+on+carcinogenicity+of+N-nitrosomethylaniline+in+F344+rats.&rft.au=Kroeger-Koepke%2C+M+B%3BReuber%2C+MD%3BIype%2C+P+T%3BLijinsky%2C+W%3BMichejda%2C+C+J&rft.aulast=Kroeger-Koepke&rft.aufirst=M&rft.date=1983-01-01&rft.volume=4&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity ER - TY - JOUR T1 - Ligand effects on the limited proteolysis of phenylalanine hydroxylase: Evidence for multiple conformational states. AN - 13534065; 422847 AB - The effects of phenylanine and tetrahydrobiopterin on the limited proteolysis of rat liver phenylalanine hydroxylase by chymotrypsin have been examined. The presence of tetrahydrobiopterin inhibits the proteolytic activation of native phenylalanine hydroxylase. In contrast, phenylalaine causes a stimulation of proteolytic activation under these conditions. neither pheylalanine nor tetrahydrobiopterin affect the rate of hydrolysis of a synthetic substrate by chymotrypsin. Both tetrahydrobiopterin and phenylalanine inhibit the release of soluble radioactivity from ( super(32)P)Phosphorylated phenylalanine hydroxylase. These results confirm the existence of multiple conformational states of phenylalanine hydroxylase. JF - Biochemical and Biophysical Research Communications AU - Phillips, R S AU - Iwaki, M AU - Kaufman, S AD - Lab. Neurochem., NIMH, Bethesda, MD 20205, USA Y1 - 1983 PY - 1983 DA - 1983 SP - 919 EP - 925 VL - 110 IS - 3 SN - 0006-291X, 0006-291X KW - binding KW - conformational analysis KW - effects on KW - liver KW - phenylalanine KW - phenylalanine 4-monooxygenase KW - proteolysis KW - rats KW - tetrahydrobiopterin KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13534065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Ligand+effects+on+the+limited+proteolysis+of+phenylalanine+hydroxylase%3A+Evidence+for+multiple+conformational+states.&rft.au=Phillips%2C+R+S%3BIwaki%2C+M%3BKaufman%2C+S&rft.aulast=Phillips&rft.aufirst=R&rft.date=1983-01-01&rft.volume=110&rft.issue=3&rft.spage=919&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Dynamics of the flow of perilymph in the cochlea of the guinea pig. AN - 85251169; pmid-7115182 AB - The dynamics of perilymph flow in the cochlea was studied in guinea pigs. After placement of sodium chloride crystals on the round window membrane, the potassium ion concentration in the scala vestibuli in the basal turn does not change. The potassium ion concentrations in the scala tympani in the basal turn increases rapidly, while the potassium ion concentration in the scala tympani in the third turn increases slowly and to a lesser extent. The cochlear microphonic potential decreases in the basal turn and to a lesser extent in the third turn. After placement of sodium chloride on the fenestra in the scala tympani of the third turn, the chochlear microphonic potential in the basal turn does not change. These data lend support to the theory of longitudinal flow of perilymph in the scala tympani. JF - Archives of Otolaryngology (Chicago, Ill. : 1960) AU - Huangfu, M AU - Komune, S AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1982 SP - 535 EP - 538 VL - 108 IS - 9 SN - 0003-9977, 0003-9977 KW - Cochlea KW - Evoked Potentials KW - Guinea Pigs KW - Animal KW - Potassium KW - Perilymph KW - Sodium Chloride KW - Electrophysiology KW - Scala Tympani KW - Cochlear Microphonic Potentials KW - Labyrinthine Fluids KW - Round Window UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85251169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Otolaryngology+%28Chicago%2C+Ill.+%3A+1960%29&rft.atitle=Dynamics+of+the+flow+of+perilymph+in+the+cochlea+of+the+guinea+pig.&rft.au=Huangfu%2C+M%3BKomune%2C+S%3BSnow%2C+J+B&rft.aulast=Huangfu&rft.aufirst=M&rft.date=1982-09-01&rft.volume=108&rft.issue=9&rft.spage=535&rft.isbn=&rft.btitle=&rft.title=Archives+of+Otolaryngology+%28Chicago%2C+Ill.+%3A+1960%29&rft.issn=00039977&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Nature of the endocochlear dc potential in kanamycin-poisoned guinea pigs. AN - 85248274; pmid-7092665 AB - The endocochlear dc potential (EP) was measured in normal guinea pigs and in a group poisoned with kanamycin sulfate for 60 minutes after the administration of furosemide intravenously (IV) or by perfusion into the scala tympani. The EP decreased rapidly and developed a large negative potential after IV administration of furosemide, but the EP decreased more slowly and did not develop a negative potential in kanamycin-poisoned animals. With perfusion of the scala media, the EP declined slowly and did not develop a large negative potential in either group. With perfusion of the scala tympani, the EP declined slowly in the kanamycin-poisoned animals and did not develop a large negative potential, while in the normal animals the EP declined rapidly and developed a large negative potential. JF - Archives of Otolaryngology (Chicago, Ill. : 1960) AU - Komune, S AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1982 SP - 334 EP - 338 VL - 108 IS - 6 SN - 0003-9977, 0003-9977 KW - Cochlea KW - Cochlear Duct KW - Comparative Study KW - Perfusion KW - Guinea Pigs KW - Animal KW - Evoked Potentials, Auditory KW - Stria Vascularis KW - Kanamycin KW - Scala Tympani KW - Furosemide KW - Infusions, Parenteral UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85248274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Otolaryngology+%28Chicago%2C+Ill.+%3A+1960%29&rft.atitle=Nature+of+the+endocochlear+dc+potential+in+kanamycin-poisoned+guinea+pigs.&rft.au=Komune%2C+S%3BSnow%2C+J+B&rft.aulast=Komune&rft.aufirst=S&rft.date=1982-06-01&rft.volume=108&rft.issue=6&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=Archives+of+Otolaryngology+%28Chicago%2C+Ill.+%3A+1960%29&rft.issn=00039977&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Anacardic acid: molluscicide in cashew nut shell liquid. AN - 734207328; 17402106 AB - The components of anacardic acid, (a mixture of 6-n-C (15) alkylsalicylic acids whose side chains vary in degrees of unsaturation) have been isolated by high pressure liquid chromatography from a crude extract of cashew nut shell, Anacardium occidentale, and tested for toxicity to fresh water snails, Biomphalaria glabrata. The triene component is the most toxic form (LC (50) 0.35 ppm), the diene and monoene components are less toxic (LC (50) 0.9 and 1.4 ppm), and the saturated component is relatively nontoxic (LC (50) > 5 ppm). Since decarboxylated anacardic acid (cardanol) and salicylic acid do not kill snails at concentrations up to 5 ppm, it appears that both, carboxyl group and unsaturated side chain are absolutely required for molluscicidal activity. The mechanism of toxicity of anacardic acid to snails is unknown. JF - Planta medica AU - Sullivan, J T AU - Richards, C S AU - Lloyd, H A AU - Krishna, G AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, U.S.A. Y1 - 1982/03// PY - 1982 DA - March 1982 SP - 175 EP - 177 VL - 44 IS - 3 SN - 0032-0943, 0032-0943 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734207328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Planta+medica&rft.atitle=Anacardic+acid%3A+molluscicide+in+cashew+nut+shell+liquid.&rft.au=Sullivan%2C+J+T%3BRichards%2C+C+S%3BLloyd%2C+H+A%3BKrishna%2C+G&rft.aulast=Sullivan&rft.aufirst=J&rft.date=1982-03-01&rft.volume=44&rft.issue=3&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Planta+medica&rft.issn=00320943&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-07-04 N1 - Date created - 2007-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The roles of vitamin E and unsaturated fatty acids in the visual process. AN - 80394802; 6101134 AB - Relatively high proportions of long-chain, polyunsaturated fatty acids seem to be required in rod photoreceptor membranes in order to provide the precise microenvironment for the proper function of the visual pigment rhodopsin. At the same time, such high levels of lipid unsaturation put the photoreceptor membranes at a high risk for autoxidation. The antioxidant vitamin E which can minimize autoxidation of polyunsaturated fatty acids is found in rather high concentrations in the outer segment membranes. Dietary deficiency in vitamin E induces disintegration of rod outer segment membranes, probably by increasing autoxidation. Also, it greatly accelerates the accumulation of aging pigments in the retinal pigment epithelium, probably because these lipofuscin granules do indeed represent the end products of lipid peroxidation. Vitamin E supplements, up to threefold normal levels, appear to provide no significant protection of the retina from light damage produced either by short but acute or by long-term, low level exposures to light. This is not consistent with current theories which implicate lipid peroxidation in the destruction of rod outer segments in light damaged retinas; more work is needed before any relation between retinal light damage and vitamin E levels can be assessed. Surprisingly, the amount of lipofuscin granule accumulation in the retinal pigment epithelium is influenced dramatically by dietary levels of vitamin A. Even retinas lacking a source of polyunsaturated fatty acids from rod outer segments still may accumulate massive lipofuscin if dietary vitamin A is provided. Perhaps vitamin A, which has such a dynamic relationship with the retinal pigment epithelium, becomes oxidized, and then contributes to the formation of a lipofuscin-like pigment. Centrophenoxine, a drug claimed to be effective in reversing the accumulation of age-related lipofuscin in the central nervous system, has no obvious effect in the eye or uterus in removing the lipofuscin granules induced by vitamin E deficiency. Microperoxisomes are abundant in the retinal pigment epithelium, and may be associated with rapid lipid turnover and/or utilization of lipid soluble vitamins. Their potential roles, however, need further documentation and clarification. Recently developed techniques and new discoveries in lipid research open the way for many fruitful studies on the interactions and precise roles of lipids and lipid-soluble vitamins in vision. JF - Retina (Philadelphia, Pa.) AU - Robison, W G AU - Kuwabara, T AU - Bieri, J G AD - Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland, MD 20205. Y1 - 1982 PY - 1982 DA - 1982 SP - 263 EP - 281 VL - 2 IS - 4 SN - 0275-004X, 0275-004X KW - Fatty Acids, Unsaturated KW - 0 KW - Lipofuscin KW - Vitamin A KW - 11103-57-4 KW - Vitamin E KW - 1406-18-4 KW - Index Medicus KW - Light -- adverse effects KW - Retina -- injuries KW - Radiation Injuries, Experimental -- pathology KW - Animals KW - Retina -- physiology KW - Humans KW - Vitamin E Deficiency -- pathology KW - Lipofuscin -- physiology KW - Vitamin A -- physiology KW - Retina -- pathology KW - Phagocytosis KW - Fatty Acids, Unsaturated -- physiology KW - Vitamin E -- physiology KW - Vision, Ocular -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80394802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Retina+%28Philadelphia%2C+Pa.%29&rft.atitle=The+roles+of+vitamin+E+and+unsaturated+fatty+acids+in+the+visual+process.&rft.au=Robison%2C+W+G%3BKuwabara%2C+T%3BBieri%2C+J+G&rft.aulast=Robison&rft.aufirst=W&rft.date=1982-01-01&rft.volume=2&rft.issue=4&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Retina+%28Philadelphia%2C+Pa.%29&rft.issn=0275004X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-18 N1 - Date created - 1993-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vivo and in vitro NO sub(2) exposures enhance phagocytic and tumoricidal activities of rat alveolar macrophages. AN - 15562357; 423630 AB - Rat alveolar macrophages (AM) were exposed in vivo or in vitro to nitrogen dioxide (NO2) and subsequently tested for phagocytic and tumoricidal activities. AM obtained by lavage from Fischer 344/N rats exposed for 4 h to 40 ppm NO sub(2) were significantly more phagocytic to opsonized sheep red blood cells (SRBC), exhi bited an increased cytotoxic response toward syngeneic mammary adenocarcinoma cells, and were more sensitive to activation by agents. The experiments suggest that the host AM-mediated immune defense of the lung may be modulated by host exposure to inhaled chemicals. JF - Journal of Toxicology and Environmental Health AU - Sone , S AU - Brennan, M AU - Creasia, DA AD - In Vivo Carinog. Program, Build. 539, NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 151 EP - 163 VL - 11 IS - 1 SN - 0093-4108, 0093-4108 KW - effects on KW - nitrogen dioxide KW - rats KW - Immunology Abstracts; Toxicology Abstracts KW - antitumor activity KW - alveoli KW - macrophages KW - phagocytosis KW - F 06789:Experimental KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15562357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=In+vivo+and+in+vitro+NO+sub%282%29+exposures+enhance+phagocytic+and+tumoricidal+activities+of+rat+alveolar+macrophages.&rft.au=Sone+%2C+S%3BBrennan%2C+M%3BCreasia%2C+DA&rft.aulast=Sone+&rft.aufirst=S&rft.date=1982-01-01&rft.volume=11&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - macrophages; phagocytosis; antitumor activity; alveoli ER - TY - JOUR T1 - A previously unidentified gene in the spc operon of Escherichia coli K12 specifies a component of the protein export machinery. AN - 15562091; 420062 AB - The gene prlA codes for a factor that appears to function in the export of proteins in Escherichia coli . This conclusion is based on the finding that mutations altering the prlA gene product restore export of envelope proteins with defective signal sequences. Evidence from gene fusions constructed in vitro suggests that prlAcodes for a protein containing at least 300 amino acids. Thus a heretofore unifentified protein specified by a gene within the spc operon appears to be a component of the cellular protein export machinery. JF - Cell AU - Shultz, J AU - Silhavy, T J AU - Berman, M L AU - Fiil, N AU - Emr, S D AD - Cancer Biology Program NCI-Frederick Cancer Res. Facility, P.O. Box B, Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 227 EP - 235 VL - 31 IS - 1 SN - 0092-8674, 0092-8674 KW - prl gene KW - role KW - excretion KW - Microbiology Abstracts B: Bacteriology KW - genes KW - gene mapping KW - Escherichia coli KW - proteins KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15562091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell&rft.atitle=A+previously+unidentified+gene+in+the+spc+operon+of+Escherichia+coli+K12+specifies+a+component+of+the+protein+export+machinery.&rft.au=Shultz%2C+J%3BSilhavy%2C+T+J%3BBerman%2C+M+L%3BFiil%2C+N%3BEmr%2C+S+D&rft.aulast=Shultz&rft.aufirst=J&rft.date=1982-01-01&rft.volume=31&rft.issue=1&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Cell&rft.issn=00928674&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; genes; proteins; gene mapping ER - TY - JOUR T1 - Measurement of M. luteus endonuclease-sensitive lesions by alkaline elution. AN - 15560045; 418986 AB - The UV-endonuclease approach to detect DNA damage has been combined with the alkaline elution technique with a resultant marked increase in sensitivity compared to the conventional method using alkaline sedimentation. DNA from UV-irradiated cells was digested on an inert filter with an extract from M. luteus and then analyzed by alkaline elution. Endonuclease-sensitive sites (endo-sites) were measured after doses of 0.08-0.7 Jm super(-2) of UV-radiation. An estimate of endo-site production with UV radiation, 0.27 endo-sites/10 super(8) daltons of DNA/0.1 Jm super(-2), was similar to that usually seen at higher doses by others. The kinetics of removal of the endo-sites induced by MNNG were similar in normal cells and human cells of the mer super(-) phenotype which had been shown to be more sensitive by cell killing to alkylating-agent damage. This should prove to be a useful approach to study DNA damage and repair since the entire assay can be done in several hours and a very low level of damage (1 endo-site/2 x 10 super(9) daltons of DNA) can be detected. JF - Mutation Research AU - Fornace, AJ Jr AD - Lab. Pathol., N.C.I., N.I.H., Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 263 EP - 276 VL - 94 IS - 2 SN - 0027-5107, 0027-5107 KW - sensitivity KW - measuring techniques KW - endonuclease KW - Microbiology Abstracts B: Bacteriology KW - lesions KW - DNA KW - Micrococcus luteus KW - J 02725:DNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15560045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research&rft.atitle=Measurement+of+M.+luteus+endonuclease-sensitive+lesions+by+alkaline+elution.&rft.au=Fornace%2C+AJ+Jr&rft.aulast=Fornace&rft.aufirst=AJ&rft.date=1982-01-01&rft.volume=94&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Mutation+Research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Micrococcus luteus; DNA; lesions ER - TY - JOUR T1 - Overview of phthalate ester pharmacokinetics in mammalian species. AN - 15556290; 423801 JF - Environmental Health Perspectives AU - Kluwe, WM AD - Natl. Toxicol. Prog., NIEHS, P.O. Box 12233, Research Triagle Park, NC 27709, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 3 EP - 10 VL - 45 SN - 0091-6765, 0091-6765 KW - phthalic acid esters KW - bis-(2-ethylhexyl) phthalic acid KW - Toxicology Abstracts KW - reviews KW - plasticizers KW - metabolism KW - X 24153:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15556290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Overview+of+phthalate+ester+pharmacokinetics+in+mammalian+species.&rft.au=Kluwe%2C+WM&rft.aulast=Kluwe&rft.aufirst=WM&rft.date=1982-01-01&rft.volume=45&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - metabolism; reviews; plasticizers ER - TY - JOUR T1 - The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbital-induced sleeping time in rats and mice. AN - 15555190; 407836 AB - In a 6- to 8-month dose-response toxicity study, methapyrilene hydrochloride (HCl) was administered in the feed to Fischer-344/N rats and B6C3F1 mice at concentrations of 125, 250, 500, 1000, or 2000 ppm. After 26 weeks, rats fed the higher dose levels of methapyrilene HCl developed cholangiocellular carcinomas in addition to severe hepatotoxic lesions. After 31 weeks, mice exhibited only mild hepatotoxicity from ingesting methapyrilene HCl, even at the higher dose levels. The duration of sodium pentobarbital-induced sleeping time (PEN-induced ST) is determined by the rate of hepatic mebabolism of PEN and can therefore be used as an in vivo measurement of the level of hepatic detoxifying enzymes. A subsequent study was undertaken with PEN-induced ST to investigate differences in the effect of methapyrilene HCl on hepatic detoxifying enzymes between the two species. JF - Toxicology and Applied Pharmacology AU - Brennan, L M AU - Creasia, DA AD - Carcinog. Prog., NCI-Frederick Cancer Res. Facility, P.O. Box B, Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 252 EP - 258 VL - 66 IS - 2 SN - 0041-008X, 0041-008X KW - effects on KW - liver KW - induction KW - sleep KW - methapyrilene hydrochloride KW - pentobarbitone KW - mice KW - rats KW - Toxicology Abstracts KW - carcinogenicity KW - X 24112:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15555190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=The+effects+of+methapyrilene+hydrochloride+on+hepatocarcinogenicity+and+pentobarbital-induced+sleeping+time+in+rats+and+mice.&rft.au=Brennan%2C+L+M%3BCreasia%2C+DA&rft.aulast=Brennan&rft.aufirst=L&rft.date=1982-01-01&rft.volume=66&rft.issue=2&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity ER - TY - JOUR T1 - Procedures for the purification of interleukin 3 to homogeneity. AN - 15553934; 412316 AB - A procedure is described for the routine purification of IL 3 to homogeneity from WEHI-3-conditioned media. The last step in purification involves chromatography on C sub(18) hydrophobic supports in RP-HPLC systems, which results in the coelution of a protein peak and IL 3 activity. The purfication sequence results in approximately a 1,000,000-fold purfication from the initial starting material with yields of 5 to 10% of the initial activity. Typically, 150 liters of conditioned media yields 2 to 10 mu g of IL 3. The purified material was homogeneous by SDS-PAGE analysis and had an apparent m.w. of 28,000. Purified IL 3 had a specific activity of approximately 0.05 ng/unit of activity. Additional criteria used to establish the relationship of the 28,000-dalton protein to IL 3 include the ability of an antiserum against IL 3 to concomitantly immunoprecipitate the iodinated protein and to inhibit its biologic activity as well as the ability of the iodinated protein to bind specifically to cell lines known to require IL 3 for growth. JF - Journal of Immunology AU - Ihle, J N AU - Keller, J AU - Henderson, L AU - Klein, F AU - Palaszynski, E AD - NCI-Frederick Cancer Res. Fac., Biol. Carcinogenesis Program, P.O. Box B, Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 2431 EP - 2436 VL - 129 IS - 6 SN - 0022-1767, 0022-1767 KW - interleukin 3 KW - methodology KW - purification KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - F 06773:Interferons KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15553934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Procedures+for+the+purification+of+interleukin+3+to+homogeneity.&rft.au=Ihle%2C+J+N%3BKeller%2C+J%3BHenderson%2C+L%3BKlein%2C+F%3BPalaszynski%2C+E&rft.aulast=Ihle&rft.aufirst=J&rft.date=1982-01-01&rft.volume=129&rft.issue=6&rft.spage=2431&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - interleukin 3 ER - TY - JOUR T1 - Tumor induction in Sencar mice in response to ultraviolet radiation. AN - 15553658; 408065 AB - The purpose of this study was to ascertain whether Sencar mice, which are extremely susceptible to two-stage skin carcinogenesis by chemical carcinogens, also exhibit increased susceptibility to carcinogenesis by ultraviolet radiation (UVR). The results indicate that the hypersensitivity of Sencar mice to tumor induction in skin exists not only with respect to chemical carcinogens but also with respect to at least one physical carcinogen (UVR). JF - Carcinogenesis AU - Strickland, P T AD - Cancer Biol. Program, NCI-Frederick Cancer Res. Fac., Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 1487 EP - 1489 VL - 3 IS - 12 SN - 0143-3334, 0143-3334 KW - induction KW - mice KW - Toxicology Abstracts KW - tumors KW - skin KW - u.v. radiation KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15553658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Tumor+induction+in+Sencar+mice+in+response+to+ultraviolet+radiation.&rft.au=Strickland%2C+P+T&rft.aulast=Strickland&rft.aufirst=P&rft.date=1982-01-01&rft.volume=3&rft.issue=12&rft.spage=1487&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - u.v. radiation; tumors; skin ER - TY - JOUR T1 - Physicochemical and biological comparison of polyene macrolide antibiotics fungichromin, lagosin and cogomycin. AN - 15550730; 399589 AB - The three polyene macrolide antibiotics, fungichromin, lagosin, and cogomycin, previously described as having some stereochemical differences at one or more centers, are shown by countercurrent distribution, high-performance liquid chromatography, carbon-13 nuclear magnetic resonance spectroscopy, circular dichroism, and biological studies to be identical in all respects, including stereochemical aspects. The differences observed earilier in their properties have now been ascribed to varying amounts of impurities, which are separable by high-performance liquid chromatography. All three antibiotics contain one major and several minor components. JF - Journal of Antibiotics AU - Pandey, R C AU - Guenther, E C AU - Aszalos, A A AU - Brajtburg, J AD - NCI-FCRF Fermentation Prog., NCI-Frederick Cancer Res. Fac. P.O. Box B, Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 988 EP - 996 VL - 35 IS - 8 SN - 0021-8820, 0021-8820 KW - comparison KW - physicochemical properties KW - fungichromin KW - lagosin KW - cogomycin KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Streptomyces KW - biological properties KW - A 01095:Others KW - J 02781:Biosynthesis and physicochemical properties UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15550730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antibiotics&rft.atitle=Physicochemical+and+biological+comparison+of+polyene+macrolide+antibiotics+fungichromin%2C+lagosin+and+cogomycin.&rft.au=Pandey%2C+R+C%3BGuenther%2C+E+C%3BAszalos%2C+A+A%3BBrajtburg%2C+J&rft.aulast=Pandey&rft.aufirst=R&rft.date=1982-01-01&rft.volume=35&rft.issue=8&rft.spage=988&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antibiotics&rft.issn=00218820&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Streptomyces; biological properties ER - TY - JOUR T1 - Dose-response studies with nitroso-1,2,3,6-tetrahydropyridine and dinitrosohomopiperazine in F344 rats. AN - 15544321; 383092 AB - Dose-response studies were carried out on female F344 rats with two carcinogenic cyclic nitrosamines, nitroso-1,2,3,6-tetrahydropyridine (NTHP) and dinitrosohomopiperazine (DNHP). Groups of 20 rats were given the nitrosamines in drinking water solution, at concentrations ranging from 100 to 1 mg/liter of the former and 110 to 1.1 mg/liter of the latter, each lower dose being 40% of the dose above it. The relationship between dose of nitrosamine and carcinogenic potency, as measured by mortality rate, was linear over part of the range, but not at lower doses. The slopes of these dose responses differed between NTHP-and DNHP-treated animals, suggesting that the mechanisms of carcinogenesis by these two compounds are not identical. JF - ECOTOXICAL. ENVIRON. SAF. AU - Lijinsky, W AU - Reuber, MD AU - Davies, T C AU - Riggs, C W AD - Chem. Carcin. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 513 EP - 527 VL - 6 IS - 6 KW - nitro-1,2,3,6-tetrahydropyridine KW - dinitrosohomopiperazine KW - rats KW - Toxicology Abstracts KW - carcinogenicity KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15544321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ECOTOXICAL.+ENVIRON.+SAF.&rft.atitle=Dose-response+studies+with+nitroso-1%2C2%2C3%2C6-tetrahydropyridine+and+dinitrosohomopiperazine+in+F344+rats.&rft.au=Lijinsky%2C+W%3BReuber%2C+MD%3BDavies%2C+T+C%3BRiggs%2C+C+W&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1982-01-01&rft.volume=6&rft.issue=6&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=ECOTOXICAL.+ENVIRON.+SAF.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity ER - TY - JOUR T1 - Solubilization and partial purification of the high affinity ( super(3)H) imipramine binding site from human platelets. AN - 15544074; 387671 JF - FEBS Letters AU - Rehavi, M AU - Skolnick, P AU - Paul, S M AD - Clin. Neurosci. Branch, NIMH, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 514 EP - 518 VL - 150 IS - 2 SN - 0014-5793, 0014-5793 KW - characterization KW - imipramine KW - man KW - platelets KW - purification KW - receptors KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 1: Biological Membranes (till 1993) KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15544074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Solubilization+and+partial+purification+of+the+high+affinity+%28+super%283%29H%29+imipramine+binding+site+from+human+platelets.&rft.au=Rehavi%2C+M%3BSkolnick%2C+P%3BPaul%2C+S+M&rft.aulast=Rehavi&rft.aufirst=M&rft.date=1982-01-01&rft.volume=150&rft.issue=2&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Identification of a M sub(r) 58,000 glycoprotein subunit of the opiate receptor. AN - 15540231; 379994 AB - A M sub(r) 58,000 subunit of the opiate receptor has been identified using tritiated fentanyl isothiocyanate, a potent opiate alkylating reagent with specificity for the delta -opiate receptor subclass. The subunit is alkylated in the presence of dextrorphan but not levorphanol. The specifically labelled protein was retained on columns of immobilized wheat germ agglutinin and is therefore presumably a glycoprotein. Partial purification of M sub(r) 58,000 opiate receptor subunit from neuroblastoma x glioma NG108-15 hybrid cell membranes is described. JF - FEBS Letters AU - Klee, WA AU - Simonds, W F AU - Sweat, F W AU - Burke, TR Jr AU - Jacobson, A E AU - Rice, K C AD - Lab. Gen. & Comp. Biochem., NIMH, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 125 EP - 128 VL - 150 IS - 1 SN - 0014-5793, 0014-5793 KW - characterization KW - glioma cells KW - neuroblastoma cells KW - opiates KW - purification KW - receptors KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts; Biochemistry Abstracts 1: Biological Membranes (till 1993) KW - N3 11070:Neurochemistry and cellular biology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15540231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Identification+of+a+M+sub%28r%29+58%2C000+glycoprotein+subunit+of+the+opiate+receptor.&rft.au=Klee%2C+WA%3BSimonds%2C+W+F%3BSweat%2C+F+W%3BBurke%2C+TR+Jr%3BJacobson%2C+A+E%3BRice%2C+K+C&rft.aulast=Klee&rft.aufirst=WA&rft.date=1982-01-01&rft.volume=150&rft.issue=1&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - neuroblastoma cells; opiates; glioma cells ER - TY - JOUR T1 - Postnatal development and behavior in offspring of enflurane exposed pregnant rats. AN - 15538226; 382388 AB - Sperm positive (day zero gestation) Fischer 344 rats were exposed to air or to 1500 ppm enflurane by inhalation for 6 hr a day for 21 consecutive days. Enflurane exposed females and their controls were allowed to deliver and raise their offspring. Offspring were studied for evidence of abnormal development as two day, 4, 8, 14 and 80 to 90 week old animals. The authors conclude that offspring of pregnant female rats exposed to enflurane at 1500 ppm throughout gestation show minimal, if any, significant clinical or behavioral pathological effects. JF - Archives Internationales de Pharmacodynamie et Therapie AU - Peters, MA AU - Hudson, P M AD - Natl. Inst. Environ. Health Sci. (NIEHS), Research Triangle Park, NC 27709, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 134 EP - 144 VL - 256 IS - 1 SN - 0003-9780, 0003-9780 KW - effects on KW - offspring KW - enflurane KW - rats KW - Animal Behavior Abstracts; Toxicology Abstracts KW - intrauterine exposure KW - anesthetics KW - maze learning KW - X 24112:Chronic exposure KW - Y 25817:Mammals (excluding primates) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15538226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+Internationales+de+Pharmacodynamie+et+Therapie&rft.atitle=Postnatal+development+and+behavior+in+offspring+of+enflurane+exposed+pregnant+rats.&rft.au=Peters%2C+MA%3BHudson%2C+P+M&rft.aulast=Peters&rft.aufirst=MA&rft.date=1982-01-01&rft.volume=256&rft.issue=1&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Archives+Internationales+de+Pharmacodynamie+et+Therapie&rft.issn=00039780&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - intrauterine exposure; anesthetics; maze learning ER - TY - JOUR T1 - Development and requirements of modern quality assurance. AN - 15537284; 396955 AB - The need for quality in welded products and associated materials is discussed and factors affecting quality considered. The use of current quality assurance systems to control products is examined and some areas identified which cause difficulties in operation. The role of the newly-established Pressure Vessel Quality Assurance Board (PVQAB) is described and the need for a more uniform utilization of National Quality Standards, e.g. B.S. 5750, stressed. JF - QUAL. ASSURANCE. AU - Gifford, A F AD - NEI Mech. Eng., Derby, UK Y1 - 1982 PY - 1982 DA - 1982 SP - 68 EP - 72 VL - 8 IS - 3 KW - product liability KW - pressure vessels KW - federal programs KW - quality control KW - standards KW - welding KW - Health & Safety Science Abstracts; Mechanical Engineering Abstracts (ISMEC) KW - H SI9.5:STANDARDS, LAWS, REGULATIONS, AND POLICY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15537284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=QUAL.+ASSURANCE.&rft.atitle=Development+and+requirements+of+modern+quality+assurance.&rft.au=Gifford%2C+A+F&rft.aulast=Gifford&rft.aufirst=A&rft.date=1982-01-01&rft.volume=8&rft.issue=3&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=QUAL.+ASSURANCE.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - quality control; welding; federal programs; standards ER - TY - JOUR T1 - Sequence information within the lamB gene is required for proper routing of the bacteriophage lambda receptor protein to the outer membrane of Escherichia coli K-12. AN - 15537154; 381330 AB - A series of hybrid genes has been constructed by fusion of the gene (lamB ) coding for the outer membrane lambda receptor protein (LamB), and the gene coding for the cytoplasmic enzyme beta -galactosidase, lacZ . The resultant hybrid proteins of this series contain varying amounts of LamB at the NH sub(2) terminus and a constant amount of functional beta -galactosidase at the COOH terminus. The amount of lamB-coded protein present varies from two to about 270 amino acids of the 450 amino acids found in the mature LamB protein. The largest hybrid protein is novel, exhibiting several unique properties. It is efficiently localized to the outer membrane, exhibits an extremely low beta -galactosidase specific activity, and is insoluble in Triton X-100. Other hybrid proteins, containing shorter LamB sequences, are localized less efficiently or not at all. The results suggest that additional information within LamB, residing downstream from the NH sub(2)-terminal signal sequence, is required for proper routing of the protein to the outer membrane. JF - Journal of Molecular Biology AU - Hall, M N AU - Schwartz, M AU - Silhavy, T J AD - Cancer Biol. Prog., NCI-Frederick Cancer Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 93 EP - 112 VL - 156 IS - 1 SN - 0022-2836, 0022-2836 KW - lamB gene KW - role KW - transport KW - receptors KW - incorporation KW - lacZ gene KW - fusion KW - Escherichia coli KW - genes KW - genetic engineering KW - membrane proteins KW - outer membranes KW - phage lambda KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biochemistry Abstracts 1: Biological Membranes (till 1993); Microbiology Abstracts B: Bacteriology KW - N 14661:ROLE AS A GENE (INCLUDING GENETIC MANIPULATION) KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15537154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Sequence+information+within+the+lamB+gene+is+required+for+proper+routing+of+the+bacteriophage+lambda+receptor+protein+to+the+outer+membrane+of+Escherichia+coli+K-12.&rft.au=Hall%2C+M+N%3BSchwartz%2C+M%3BSilhavy%2C+T+J&rft.aulast=Hall&rft.aufirst=M&rft.date=1982-01-01&rft.volume=156&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; phage lambda; genes; membrane proteins; outer membranes; genetic engineering ER - TY - JOUR T1 - Microbial flora in chronic otitis media. AN - 15536299; 369763 AB - The microbial flora of the exudates of 100 consecutive cases of chronic suppurative otitis media was investigated. All but one case yielded at least one organism and 35 cases produced two or more organisms. 146 isolates were obtained of which 121 were aerobic bacteria, 21 were anaerobic bacteria and four were fungi. Anaerobes were present in 20 per cent of patients. At the time of the investigation 34 patients were receiving antimicrobial agents. Antibiotic sensitivity tests were carried out on all bacterial isolates. The possibility of an anaerobic infection should not be overlooked when considering the treatment of otitis. JF - Journal of Infection AU - Constable, L AU - Butler, I AD - Dep. Microbiol., Royal Victoria Infirm., Newcastle upon Tyne NEI 4LP, UK Y1 - 1982 PY - 1982 DA - 1982 SP - 57 EP - 60 VL - 5 IS - 1 SN - 0163-4453, 0163-4453 KW - exudates KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - treatment KW - otitis media KW - fungi KW - man KW - microflora KW - antibiotic sensitivity testing KW - bacteria KW - antimicrobial agents KW - K 03087:Fungi: human KW - A 01069:Antimicrobial & microbiocidal KW - J 02845:Ear, nose and respiratory tract KW - J 02783:Antibiotics: General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15536299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infection&rft.atitle=Microbial+flora+in+chronic+otitis+media.&rft.au=Constable%2C+L%3BButler%2C+I&rft.aulast=Constable&rft.aufirst=L&rft.date=1982-01-01&rft.volume=5&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infection&rft.issn=01634453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - microflora; otitis media; man; antimicrobial agents; treatment; antibiotic sensitivity testing; bacteria; fungi ER - TY - JOUR T1 - Toxicity, tissue distribution, and excretion of benzyl chloride in the rat. AN - 15532156; 368848 AB - The tissue distribution and excretion of ( super(14)C) benzyl chloride was investigated in adult male and female Fischer 344/N rats after administration of a single oral dose of ( super(14)C)benzyl chloride in corn oil at 25 mg/kg. Data was correlated with histopathologic and toxicity findings elicited from a 27-37-wk repeated-dose oral toxicity study of benzyl chloride. Elimination of the isotope occurred predominantly in the urine. Results of acute toxicity and organ histopathology studies in animals dosed with benzyl chloride for 27-37 wk are compatible with the organ distribution and excretion of ( super(14)C)benzyl chloride. Histopathologic findings included severe acute and chronic gastritis, hyperkeratosis and hyperplasia of the squamous stomach, and progressive lesions of the heart ranging from proliferation of interstitial cells to acute necrosis of myocardial fibers. Both of these studies suggest that the squamous stomach is a target organ for benzyl chloride or one of its metabolites. JF - Journal of Toxicology and Environmental Health AU - Bunner, B L AU - Creasia, DA AD - In Vivo Carcinog. Program, Build. 539, NCI-Frederick Canc. Res. Facil., P.O. Box B, Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 837 EP - 846 VL - 10 IS - 4-5 SN - 0093-4108, 0093-4108 KW - toxicity KW - benzyl chloride KW - rats KW - Toxicology Abstracts KW - metabolism KW - excretion KW - X 24153:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15532156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=Toxicity%2C+tissue+distribution%2C+and+excretion+of+benzyl+chloride+in+the+rat.&rft.au=Bunner%2C+B+L%3BCreasia%2C+DA&rft.aulast=Bunner&rft.aufirst=B&rft.date=1982-01-01&rft.volume=10&rft.issue=4-5&rft.spage=837&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - metabolism; excretion ER - TY - JOUR T1 - Ultrastructural Changes in the Liver of Animals Treated With Methapyrilene and Some Analogs. AN - 15516033; 337675 AB - Methapyrilene is a liver carcinogen in rats and induces mitochondrial proliferation in rat liver, but appears to have no genotoxic or other effects that can be related to its carcinogenic action. A number of structural analogs of methapyrilene were administered to rats and the livers were examined for ultrastructural changes similar to those induced by methapyrilene. The ultrastructural changes induced in rat liver by methapyrilene seem, therefore, to be unique to this compound. JF - Ecotoxicology and Environmental Safety AU - Reznik-Schueller, H M AU - Lijinsky, W AD - Chem. Carcinogenesis Program NCI-Federick Cancer Res. Facility, Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 328 EP - 335 VL - 6 IS - 4 SN - 0147-6513, 0147-6513 KW - effects on KW - methapyrilene KW - rats KW - Toxicology Abstracts KW - ultrastructure KW - liver KW - X 24115:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15516033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ecotoxicology+and+Environmental+Safety&rft.atitle=Ultrastructural+Changes+in+the+Liver+of+Animals+Treated+With+Methapyrilene+and+Some+Analogs.&rft.au=Reznik-Schueller%2C+H+M%3BLijinsky%2C+W&rft.aulast=Reznik-Schueller&rft.aufirst=H&rft.date=1982-01-01&rft.volume=6&rft.issue=4&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=Ecotoxicology+and+Environmental+Safety&rft.issn=01476513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - ultrastructure; liver ER - TY - JOUR T1 - Dose-Response Studies in Carcinogenesis by Nitroso-N-Methyl-N-(2-Pnenyl)Ethylamine in Rats and the Effects of Deuterium Substitution. AN - 15515963; 336412 AB - A dose-response study of the carcinogenicity of nitroso-N-methyl-N-(2-phenyl)ethylamine was carried out in male Fischer 344 rats. The compound was given in drinking water at concentrations of 115, 28, 9 multiplied by 5, 3 multiplied by 2, 1 multiplied by 1 and 0 multiplied by 4 mg/litre. The highest concentration proved toxic leading to the early death of several animals; the remainder of this group were treated for 21 wk. All of the other concentrations were given for 33 wk, except the 28 mg/litre treatment which ceased at 30 wk. An additional group of rats was given 0 multiplied by 4 mg/litre for 104 wk. In all groups of animals, except those in the high-dose group that died early and those given 0 multiplied by 4 mg/litre for 33 wk, 50% or more of the animals had tumours of the oesophagus or forestomach or both when they died. In several groups the number of rats with these tumours approached 100%. JF - Food and Chemical Toxicology AU - Lijinsky, W AU - Reuber, MD AU - Davies, T S AU - Saavedra, JE AU - Riggs, C W AD - Chem. Carcinogen. Prog., NCI-Frederick Cancer Res. Fac., Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 393 EP - 399 VL - 20 IS - 4 SN - 0278-6915, 0278-6915 KW - analogs KW - N-nitroso-N-methyl-N-(2-phenyl)ethylamine KW - deuterium KW - carcinogenisis KW - rats KW - Toxicology Abstracts KW - structure-activity relationships KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15515963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Dose-Response+Studies+in+Carcinogenesis+by+Nitroso-N-Methyl-N-%282-Pnenyl%29Ethylamine+in+Rats+and+the+Effects+of+Deuterium+Substitution.&rft.au=Lijinsky%2C+W%3BReuber%2C+MD%3BDavies%2C+T+S%3BSaavedra%2C+JE%3BRiggs%2C+C+W&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1982-01-01&rft.volume=20&rft.issue=4&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - structure-activity relationships ER - TY - JOUR T1 - Regression of Canine Mammary Carcinoma After Immunoadsorption Therapy. AN - 15513876; 327435 AB - The plasma of dogs afflicted with mammary carcinoma was perfused through chambers bearing Staphylococcus aureus Cowan strain I in an attempt to remove tumor-promoting, immunosuppressive immune complexes from the peripheral blood of these animals. Reduction of breast and/or soft-tissue tumor was observed in five of the ten animals so treated. Immune complexes capable of blocking lymphocytotoxicity were measured pre- and postimmunoadsorption; removal was more efficient in the responders than in nonresponders. The reduction of tumor size seen in soft-tissue sites was not always accompanied by a similar reduction of tumor size in visceral sites, and surgical resection of residual soft-tissue tumor nodules remaining after immunoadsorption treatment was required to achieve a complete response in two responding animals. The data indicate that immunoadsorption of tumor-bearing host plasma can result in reduction in size of canine mammary adenocarcinoma but that the response is dependent on the site of the tumor (s.c. versus visceral) and may require utilization of other modalities to achieve a complete disappearance of the tumor. JF - Cancer Research AU - Holohan, T V AU - Phillips, T M AU - Bowles, C AU - Deisseroth, A AD - Pediatr. Oncol. Branch, DCT., NCI, NIH, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 3663 EP - 3668 VL - 42 IS - 9 SN - 0008-5472, 0008-5472 KW - effects on KW - dogs KW - mammary gland KW - tumors KW - immunoabsorption KW - treatment KW - tumor-promoting agents KW - immunosuppressive agents KW - antigen-antibody complexes KW - Health & Safety Science Abstracts; Immunology Abstracts KW - immunology KW - Staphylococcus aureus KW - cancer KW - F 06818:Cancer immunotherapy KW - H SM8.1:BASIC APPROACHES, CONCEPTS, AND THEORY KW - H SM10.21:CANCER UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15513876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Regression+of+Canine+Mammary+Carcinoma+After+Immunoadsorption+Therapy.&rft.au=Holohan%2C+T+V%3BPhillips%2C+T+M%3BBowles%2C+C%3BDeisseroth%2C+A&rft.aulast=Holohan&rft.aufirst=T&rft.date=1982-01-01&rft.volume=42&rft.issue=9&rft.spage=3663&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Staphylococcus aureus; cancer; immunology; mammary gland; tumors; immunoabsorption; treatment; tumor-promoting agents; immunosuppressive agents; antigen-antibody complexes ER - TY - JOUR T1 - A Short-Lived Effect of 2,5-Hexanedione on Thermal Perception in Mice. AN - 15513431; 339735 AB - Mice exposed to 1.0% 2,5-hexanedione (HD) in drinking water exhibited an hyperalgesia which persisted from experimental Day 7 through Day 19. Despite continued exposure to HD, no other neurological signs were detected throughout the 18-week experiment. The measurement of pain perception may offer a means of detecting early neuropathies in laboratory animals; however, the mouse is a species of doubtful utility. JF - Toxicology and Applied Pharmacology AU - Mennear, J H AD - NIEHS/NTP, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 205 EP - 210 VL - 62 IS - 2 SN - 0041-008X, 0041-008X KW - effects on KW - 2,5-hexadione KW - mice KW - Toxicology Abstracts KW - temperature perception KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15513431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=A+Short-Lived+Effect+of+2%2C5-Hexanedione+on+Thermal+Perception+in+Mice.&rft.au=Mennear%2C+J+H&rft.aulast=Mennear&rft.aufirst=J&rft.date=1982-01-01&rft.volume=62&rft.issue=2&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - temperature perception ER - TY - JOUR T1 - Analysis of Serum IgM, IgA and IgG Antibody in Brucellosis Patients. AN - 15513240; 339362 AB - The changes of IgM, IgA and IgG antibody of 22 brucellosis patients were continuously observed for two years. IgM and IgA antibody was produced at the early stage, then, IgG antibody was increased. The quantity changes of both IgG and IgM antibody sometimes can reflect the patients' condition. The presence of specific IgA antibody is related to infection through mouth. Due to the presence of IgA and its resistance to the destruction by 2 ME, it is therefore not suitable to use cysteine test and 2 ME test in quantitative analysis of IgG and IgM antibodies. JF - Chinese Journal of Microbiology and Immunology AU - Ma, H-Z AU - Wen, D-S AU - Zhou, H-Z AU - Tian, S-M AD - Inst. Endemiol., Nei Mongol Autonomous Region, Huhhot, People's Rep. China Y1 - 1982 PY - 1982 DA - 1982 SP - 182 EP - 185 VL - 2 IS - 3 SN - 0253-2662, 0253-2662 KW - serum levels KW - Microbiology Abstracts B: Bacteriology KW - brucellosis KW - Brucella KW - antibody response KW - man KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15513240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Microbiology+and+Immunology&rft.atitle=Analysis+of+Serum+IgM%2C+IgA+and+IgG+Antibody+in+Brucellosis+Patients.&rft.au=Ma%2C+H-Z%3BWen%2C+D-S%3BZhou%2C+H-Z%3BTian%2C+S-M&rft.aulast=Ma&rft.aufirst=H-Z&rft.date=1982-01-01&rft.volume=2&rft.issue=3&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Microbiology+and+Immunology&rft.issn=02532662&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Brucella; brucellosis; antibody response; man ER - TY - JOUR T1 - Comparative Carcinogenesis by Nitrosomorpholines, Nitrosooxazo Lidines and Nitrosotetrahydrooxazine in Rats. AN - 15510668; 325177 AB - A comparison was made of the carcinogenic effectiveness of some cyclic nitrosamines containing oxygen in the ring. The compounds were administered to F344 rats at approximately equimolar concentrations in drinking water. JF - Carcinogenesis AU - Lijinsky, W AU - Reuber, MD AD - Chem. Carcinogen. Prog., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 911 EP - 915 VL - 3 IS - 8 SN - 0143-3334, 0143-3334 KW - nitrosamines KW - rats KW - Toxicology Abstracts KW - carcinogenicity KW - structure-activity relationships KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15510668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Comparative+Carcinogenesis+by+Nitrosomorpholines%2C+Nitrosooxazo+Lidines+and+Nitrosotetrahydrooxazine+in+Rats.&rft.au=Lijinsky%2C+W%3BReuber%2C+MD&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1982-01-01&rft.volume=3&rft.issue=8&rft.spage=911&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - structure-activity relationships; carcinogenicity ER - TY - JOUR T1 - Detection of Gilvocarcin Antitumor Complex by a Biochemical Induction Assay (BIA). AN - 15502986; 317174 AB - The authors are currently investigating the applicability of a biochemical version of the prophage induction assay (BIA), a test for agents interacting with DNA, as a potential prescreen for new antitumor antibiotics. Use of the BIA led to the isolation of Streptomyces arenae 2064 which produced two compounds. The BIA active products from S. arenae 2064 are identical to the antitumor antibodies toromycin and gilvocarcins V and M. JF - Journal of Antibiotics AU - Wei, T T AU - Chan, JA AU - Roller, P P AU - Weiss, U AU - Stroshane, R M AU - White, R J AU - Byrne, K M AD - NCI-FCRF Fermentation Program, NCI-Frederick Cancer Res. Facility, Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 529 EP - 532 VL - 35 IS - 4 SN - 0021-8820, 0021-8820 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - screening KW - Streptomyces arenae KW - biosynthesis KW - antitumor agents KW - A 01013:Cytostatic & antitumor agents KW - J 02781:Biosynthesis and physicochemical properties UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15502986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antibiotics&rft.atitle=Detection+of+Gilvocarcin+Antitumor+Complex+by+a+Biochemical+Induction+Assay+%28BIA%29.&rft.au=Wei%2C+T+T%3BChan%2C+JA%3BRoller%2C+P+P%3BWeiss%2C+U%3BStroshane%2C+R+M%3BWhite%2C+R+J%3BByrne%2C+K+M&rft.aulast=Wei&rft.aufirst=T&rft.date=1982-01-01&rft.volume=35&rft.issue=4&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antibiotics&rft.issn=00218820&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Streptomyces arenae; antitumor agents; screening; biosynthesis ER - TY - JOUR T1 - Alteration in Blood Pressures Associated With Combined Alcohol and Oral Contraceptive Use--The Lipid Research Clinics Prevalence Study. AN - 15499295; 327960 AB - Alterations in systolic and diastolic blood pressure levels associated with combined oral contraceptive (OC) and alcohol use were investigated in white women 20-49 years of age from 10 North American Lipid Research Clinics study populations. OC users had systolic pressures 2-3 mm Hg higher than non-users, but no difference was noted for diastolic pressures. Among non-OC users, both systolic and diastolic blood pressures were positively associated with reported alcohol consumption, though participants reporting no alcohol use had blood pressures slightly higher than those reporting minimal intake. JF - J. CHRON. DIS. AU - Wallace, R B AU - Connor, E B AU - Criqui, M AU - Wahl, P AU - Hoover, J AU - Hunninghake, D AU - Heiss, G AU - Rifkind, B M AD - Lipid Metabolism-Atherogen. Branch, DHVD, NHLBI, NIH, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 251 EP - 257 VL - 35 IS - 4 KW - side effects KW - contraceptives (oral) KW - case surveys KW - man KW - contraceptives KW - alcohol KW - humans KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - cardiovascular system KW - blood pressure KW - H SE4.26:DRUGS AND ALCOHOL KW - H SM10.22:CARDIOVASCULAR SYSTEM DISEASES KW - X 24180:Social poisons & drug abuse KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15499295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+CHRON.+DIS.&rft.atitle=Alteration+in+Blood+Pressures+Associated+With+Combined+Alcohol+and+Oral+Contraceptive+Use--The+Lipid+Research+Clinics+Prevalence+Study.&rft.au=Wallace%2C+R+B%3BConnor%2C+E+B%3BCriqui%2C+M%3BWahl%2C+P%3BHoover%2C+J%3BHunninghake%2C+D%3BHeiss%2C+G%3BRifkind%2C+B+M&rft.aulast=Wallace&rft.aufirst=R&rft.date=1982-01-01&rft.volume=35&rft.issue=4&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=J.+CHRON.+DIS.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - alcohol; blood pressure; humans; cardiovascular system; contraceptives (oral); case surveys; man; contraceptives ER - TY - JOUR T1 - Syndyphalin SD-25: A Higly Selective Ligand for mu Opiate Receptors. AN - 15497520; 315280 AB - The enkephalin analogue, Tyr--D-Met--Gly--MePheol, named "syndyphalin (SD)-25" was 23,300-times and 9-times as active as morphine in the guinea pig ileum bioassay and in the tail flick analgesic test after subcutaneous administration, respectively. Here, the authors report the potency of this analogue on the mu , delta and Kappa opiate receptors using ( super(3)H)dihydromorphine (DHM), D-( super(3)H)Ala super(2),D-Leu super(5)-enkephalin (DADLEU) and ( super(3)H)ethylketocyclazocine (EKC) as their respective ligands. The results show that SD-25 is a highly specific and selective ligand for the mu opiate receptor. JF - FEBS Letters AU - Quirion, R AU - Kiso, Y AU - Pert, C B AD - Sec. Biochem. Pharmacol., Biol. Psychiatry Branch, NIMH, Clin. Cent., Room 3N 256, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 203 EP - 206 VL - 141 IS - 2 SN - 0014-5793, 0014-5793 KW - analogs KW - binding KW - enkephalin KW - opiates KW - receptors KW - specificity KW - syndyphalin KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 1: Biological Membranes (till 1993) KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15497520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Syndyphalin+SD-25%3A+A+Higly+Selective+Ligand+for+mu+Opiate+Receptors.&rft.au=Quirion%2C+R%3BKiso%2C+Y%3BPert%2C+C+B&rft.aulast=Quirion&rft.aufirst=R&rft.date=1982-01-01&rft.volume=141&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Selectivity of Alkylation and Aralkylation of Nucleic Acid Components. AN - 15497222; 328065 AB - After the recognition of the role played by environmental or occupational carcinogens in the induction of cancer in man over 200 years ago, more than one-and-a-half centuries passed before it was established that a single pure chemical compound was capable of eliciting a carcinogenic response in animals. Since the recognition of other chemical carcinogens followed almost immediately, it seemed that a good approach to understanding the mechanism of action of these noxious chemicals would be a structure-activity approach aimed at defining structural features common to all chemical carcinogens. The structural diversity among chemical carcinogens presented major difficulties, however, and for some 30 years or so, structure-activity approaches were largely applied within a specific class of chemical carcinogens, rather than across the whole spectrum of carcinogens. JF - Drug Metabolism Reviews AU - Dipple, A AU - Moschel, R C AU - Hudgins, R AD - Chem. Carcinogen. Prog., NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 249 EP - 268 VL - 13 IS - 2 SN - 0360-2532, 0360-2532 KW - nucleic acids KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - reviews KW - structure-activity relationships KW - alkylating agents KW - N 14630:Chemical reactions & interactions, including effects of radiation KW - X 24240:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15497222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Metabolism+Reviews&rft.atitle=Selectivity+of+Alkylation+and+Aralkylation+of+Nucleic+Acid+Components.&rft.au=Dipple%2C+A%3BMoschel%2C+R+C%3BHudgins%2C+R&rft.aulast=Dipple&rft.aufirst=A&rft.date=1982-01-01&rft.volume=13&rft.issue=2&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Drug+Metabolism+Reviews&rft.issn=03602532&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - structure-activity relationships; alkylating agents; reviews ER - TY - JOUR T1 - Computer Generation of Surface Distribution Maps of Measures of Brain Activity. AN - 15496328; 328293 AB - A laboratory computer system is described which will rapidly generate gray-scale maps showing the distribution of measures derived from the electrical activity of the brain, such as the electroencephalogram (EEG) or other biological measures. The system allows flexible description of electrode number and placement, mapping onto any shaped space and rapid generation of maps by integration with the data collection software. JF - COMP. BIOL. & MED. AU - Coppola, R AU - Buchsbaum AU - Rigal, F AD - Lab. Psych. and Psychopath. NIMH, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 191 EP - 199 VL - 12 IS - 3 KW - electrodes KW - electroencephalograms KW - biomedical engineering KW - computer aided analysis KW - software KW - brain KW - central nervous system KW - computer applications KW - data collection KW - mapping KW - Health & Safety Science Abstracts KW - H SM10.2:DATA ANALYSIS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15496328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=COMP.+BIOL.+%26+MED.&rft.atitle=Computer+Generation+of+Surface+Distribution+Maps+of+Measures+of+Brain+Activity.&rft.au=Coppola%2C+R%3BBuchsbaum%3BRigal%2C+F&rft.aulast=Coppola&rft.aufirst=R&rft.date=1982-01-01&rft.volume=12&rft.issue=3&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=COMP.+BIOL.+%26+MED.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - computer applications; data collection; brain; central nervous system; mapping ER - TY - JOUR T1 - The Effects of Smoking on Fertility From Gametogenesis to Implantation. AN - 15493939; 313120 AB - The literature concerning the effects of cigarette smoking, treatment with nicotine, cigarette smoke condensates, or cigarette smoke constituents on reproductive events from gametogenesis to implanatation is reviewed. Epidemiologic evidence, although scanty, suggests that cigarette smoking decreases fertility in women. Cigarette smoking is also associated with an increased frequency of menstrual abnormalities and a cigarette dose-related decrease in the age of spontaneous menopause. Similar epidemiologic studies assessing reproductive function have not been conducted among men who smoke. Several small studies have demonstrated decreased sperm counts and an increased frequency of abnormal sperm morphology among male smokers. Cessation of smoking in several of these studies has been associated with an increase in sperm number and a decrease in the frequency of sperm shape abnormalities. The literature on smoking and fertility, however, is surprisingly small. Additional experimentation, as well as epidemiological surveys of human populations, are necessary before it will be possible to make unequivocal statements concerning reproductive interference by cigarette smoke or its components. JF - Environmental Research AU - Mattison AD - Pregnancy Res. Branch, NICHD, NIH, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 410 EP - 433 VL - 28 IS - 2 SN - 0013-9351, 0013-9351 KW - effects on KW - Toxicology Abstracts KW - reviews KW - cigarette smoking KW - fertility KW - man KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15493939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=The+Effects+of+Smoking+on+Fertility+From+Gametogenesis+to+Implantation.&rft.au=Mattison&rft.aulast=Mattison&rft.aufirst=&rft.date=1982-01-01&rft.volume=28&rft.issue=2&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - cigarette smoking; fertility; reviews; man ER - TY - JOUR T1 - Studies on the Relationship of Disulfide Bonds to the Formation and Maintenance of Secondary Structure in Chicken Egg White Lysozyme. AN - 15485852; 287756 AB - The dependence of secondary structure on SS content was examined to gain further insight into the role of SS bond formation in chain folding. Lysozyme was reduced to various levels, and the products were studied with respect to remaining native structure. Ion-exchange chromatography of the carboxymethylated monomers gave the three possible reduction intermediates, containing two, four, and six carboxymethylcysteine residues per mole, in addition to the fully reduced form. The intermediates exhibited circular dichroic (CD) characteristics that were clearly nonnative, indicating alteration of the secondary structure throughout all stages of reduction. Concomitantly, there were extensive losses of enzymatic activity at intermediate levels, while no activity was found for the fully reduced form. Partially and fully reduced lysozymes were also examined for their abilities to resume native secondary structure in the absence of SS formation, as would be evidenced by a reversion to native CD characteristics. These observations are consistent with an essential role of SS bonds in forming and maintaining a major portion of the native secondary structure in lysozyme. JF - Biochemistry (Washington) AU - White, FH Jr AD - Lab. Cell Biol., NHLBI, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 967 EP - 977 VL - 21 IS - 5 SN - 0006-2960, 0006-2960 KW - C.D. KW - albumen KW - chickens KW - disulfide bonds KW - lysozyme KW - role KW - secondary structure KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15485852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Studies+on+the+Relationship+of+Disulfide+Bonds+to+the+Formation+and+Maintenance+of+Secondary+Structure+in+Chicken+Egg+White+Lysozyme.&rft.au=White%2C+FH+Jr&rft.aulast=White&rft.aufirst=FH&rft.date=1982-01-01&rft.volume=21&rft.issue=5&rft.spage=967&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Activation of Misonidazole by Rat Liver Microsomes and Purified NADPH-Cytochrome c Reductase. AN - 15483143; 295751 AB - Rat liver microsomes and purified NADPH-cytochrome c reductase metabolized ( super(14)C)misonidazole anaerobically to a reactive intermediate that covalently binds to tissue macromolecules. Air strongly inhibited the binding whereas carbon monoxide had no effect, indicating that misonidazole is activated via reduction and not by cytochrome P-450-dependent oxidation. Both systems showed an absolute requirement for NADPH and were stimulated by flavine (FAD) and paraquat. The apparent K sub(m) for misonidazole binding to microsomal protein was 0.74 mM and the apparent V sub(max) was 0.64 nmole super(14)C bound multiplied by mg super(-1) multiplied by min super(-1). At a single substrate concentration, nitrofurantoin, nitrofurazone and desmethylmisonidazole inhibited the covalent binding of misonidazole to microsomal protein by 47, 26, and 38% respectively. The effect of nitrofurantoin on the kinetics of misonidazole binding gave a complex interaction indicative of uncompetitive inhibition. JF - Biochemical Pharmacology AU - McManus, ME AU - Lang, MA AU - Stuart, K AU - Strong, J AD - Lab. Chem. Pharmacol., DTP, DCT, NCI, Natl. Inst. Health Bldg. 37, Rm. 5A19, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 547 EP - 552 VL - 31 IS - 4 SN - 0006-2952, 0006-2952 KW - NADPH-cytochrome reductase KW - activation KW - kinetics KW - liver KW - misonidazole KW - rats KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15483143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Pharmacology&rft.atitle=Activation+of+Misonidazole+by+Rat+Liver+Microsomes+and+Purified+NADPH-Cytochrome+c+Reductase.&rft.au=McManus%2C+ME%3BLang%2C+MA%3BStuart%2C+K%3BStrong%2C+J&rft.aulast=McManus&rft.aufirst=ME&rft.date=1982-01-01&rft.volume=31&rft.issue=4&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Biochemical+Pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Oocyte Destruction by Polycyclic Aromatic Hydrocarbons is Not Linked to the Inducibility of Ovarian Aryl Hydrocarbon (Benzo(a)pyrene) Hydroxylase Activity in (DBA/2N x C57BL/6N) F sub(1) x DBA/2N Backcross Mice. AN - 15482200; 289418 AB - The role of the Ah locus and ovarian aryl hydrocarbon (benzo(a)pyrene) hydroxylase activity (AHH, EC 1.14.14.1) in ovotoxicity produced by the polycyclic aromatic hydrocarbons benzo(a)pyrene (BP), 3-methylcholanthrene and 7,12-dimethylbez(a)anthrancene (DMBA) was explored in Ah-responsive and Ah-nonresponsive mice. After treatment with one of the three polycyclic hydrocarbons, ovarian AHH activity was induced only in the responsive F sub(1) x D2 phenotype, demonstrating that inducibility of avarian AHH activity is associated with the Ah super(b) allele. Although responsive and nonresponsive backcross mice differed in inducibility of ovarian AHH activity, no difference was observed in the rate of, or sensitivity to, primordial oocyte destruction by the three tested polycyclic hydrocarbons. The time course for oocyte destruction over the 15-day observation period was similar in both phenotypes. DMBA destroyed all of the primordial oocytes between 9 and 12 days after treatment with similar time courses in both responsive and nonresponsive phenotypes. JF - Pediatric Pharmacology AU - Mattison AU - Nightingale AD - Build. 10, Rm. 13N266, Pregnancy Res. Branch, NICHD, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 11 EP - 21 VL - 2 IS - 1 SN - 0270-322X, 0270-322X KW - role KW - Ah locus KW - induction KW - toxicity KW - aryl hydrocarbon hydroxylase KW - polycyclic hydrocarbons KW - benzo(a)pyrene KW - 3-methylcholanthrene KW - 7,12-dimethylbenz(a)anthracene KW - mice KW - Genetics Abstracts; Toxicology Abstracts KW - DNA KW - loci KW - X 24190:Polycyclic hydrocarbons KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15482200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+Pharmacology&rft.atitle=Oocyte+Destruction+by+Polycyclic+Aromatic+Hydrocarbons+is+Not+Linked+to+the+Inducibility+of+Ovarian+Aryl+Hydrocarbon+%28Benzo%28a%29pyrene%29+Hydroxylase+Activity+in+%28DBA%2F2N+x+C57BL%2F6N%29+F+sub%281%29+x+DBA%2F2N+Backcross+Mice.&rft.au=Mattison%3BNightingale&rft.aulast=Mattison&rft.aufirst=&rft.date=1982-01-01&rft.volume=2&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Pediatric+Pharmacology&rft.issn=0270322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - loci; DNA ER - TY - JOUR T1 - Effects of Millimeter Wave Irradiation on ATP Synthesis and Calcium Transport in Mitochondria. AN - 15470335; 280914 AB - Isolated rat liver mitochondria were exposed to continuous (cw) millimeter wave irradiation and evaluated for changes in phosphorylation of ADP and Ca super(2+) uptake and efflux. Exposures at 25 degree C at 34.92 GHz at power densities of 500 and 1000 mW/cm super(2) resulted in losses of respiratory control, decreases in levels of Ca super(2+) uptake, and increases in extents of Ca super(2+) efflux. The loss of energy coupling at high power densities of irradiation was attributed to thermal damage to the mitochondrial membranes. Exposures of mitochondrial suspensions, which were actively phosphorylating ADP, to 34.92-GHz irradiation for 2 min at power densities of up to 1000 mW/cm super(2) and to frequencies between 50 and 60 GHz at 5 mW/cm super(2) had no apparent effect on the levels of ATP synthesis linked to succinate respiration. Similarly, exposures at 34.92 GHz at power densities of 250 mW/cm super(2) or less and exposures between 50 and 60 GHz at 5 mW/cm super(2) had no apparent effect on either Ca super(2+) uptake or efflux. It is concluded that other than damage due to thermal effects, oxidative phosphorylation and Ca super(2+) transport in rat liver mitochondria are quite insensitive to millimeter wave irradiation at the frequencies, power densities, and intervals of exposures used in these studies. JF - Radiation Research AU - Melnick, R L AU - Rubenstein, C P AU - Birenbaum, L AD - Natl. Toxicol. Program, NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 348 EP - 360 VL - 89 IS - 2 SN - 0033-7587, 0033-7587 KW - transport KW - effects on KW - calcium KW - rats KW - electromagnetic radiation KW - liver KW - mitochondria KW - Toxicology Abstracts; Biochemistry Abstracts 1: Biological Membranes (till 1993); Calcium & Calcified Tissue Abstracts KW - X 24210:Radiation & radioactive materials KW - T 20019:Cellular calcium, channels and currents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15470335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Effects+of+Millimeter+Wave+Irradiation+on+ATP+Synthesis+and+Calcium+Transport+in+Mitochondria.&rft.au=Melnick%2C+R+L%3BRubenstein%2C+C+P%3BBirenbaum%2C+L&rft.aulast=Melnick&rft.aufirst=R&rft.date=1982-01-01&rft.volume=89&rft.issue=2&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - mitochondria; electromagnetic radiation; liver ER - TY - JOUR T1 - Enhancement of Sister-Chromatid Exchanges by Tumour Promoters. AN - 15468927; 279060 AB - The effect of the tumour promoters TPA, phenobarbitone and saccharin on the production of sister-chromatid exchanges (SCE) was studied. TPA produced a small but significant increase of SCE in Chinese hamster cell lines V-79 and CHO, and in a hybrid clone formed by fusion of CHO with rat liver epithelial cells. In the presence of exogenous L-cysteine the enhancement of SCE was reduced. TPA also increased the uptake of 2-deoxyglucose by the cells, to an extent similar to that of the SCE enhancement. This enhancement of SCE by TPA may be explained partly through the formation of free radicals, and partly through alterations in the cell-surface membrane and/or a transient delay in the cell-cycle progression. The other tumour promoters, phenobarbitone and saccharin, also enhanced both SCE and the uptake of 2-deoxyglucose in V-79 cells. JF - British Journal of Cancer AU - Ray-Chaudhuri, R AU - Currens, M AU - Iype, P T AD - NCI-Frederick Cancer Res. Fac., Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 769 EP - 777 VL - 45 IS - 5 SN - 0007-0920, 0007-0920 KW - induction KW - uptake KW - phenobarbitone KW - saccharin KW - phorbol myristate acetate KW - 2-deoxy-D-glucose KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Toxicology Abstracts KW - sister chromatid exchange KW - cell lines KW - X 24117:Biochemistry KW - X 24172:Plants KW - N 14920:Chromatin & chromosomes KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15468927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Enhancement+of+Sister-Chromatid+Exchanges+by+Tumour+Promoters.&rft.au=Ray-Chaudhuri%2C+R%3BCurrens%2C+M%3BIype%2C+P+T&rft.aulast=Ray-Chaudhuri&rft.aufirst=R&rft.date=1982-01-01&rft.volume=45&rft.issue=5&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - sister chromatid exchange; cell lines ER - TY - JOUR T1 - Non-Nutritive Sweeteners and Bladder Cancer. AN - 15463876; 271253 JF - American Journal of Public Health AU - Hoover, R AU - Hartge, P AD - Environ. Epidemiol. Br., NCI, NIH, Landow Build. 3C07, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 382 EP - 383 VL - 72 IS - 4 SN - 0090-0036, 0090-0036 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - chemicals KW - food additives KW - food processing industry KW - cancer KW - public health KW - H SE4.27:FOOD PROCESSING INDUSTRIES KW - H SM3.8.2:CHEMICALS (CORROSION) KW - H SM10.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15463876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Non-Nutritive+Sweeteners+and+Bladder+Cancer.&rft.au=Hoover%2C+R%3BHartge%2C+P&rft.aulast=Hoover&rft.aufirst=R&rft.date=1982-01-01&rft.volume=72&rft.issue=4&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - food additives; food processing industry; cancer; public health; chemicals ER - TY - JOUR T1 - Analogues of 8-Hydroxy-5-Deazaflavin Cofactor: Relative Activity as Substrates for 8-Hydroxy-5-Deazaflavin-Dependent NADP super(+) Reductase From Methanococcus vannielii). AN - 15463222; 267793 AB - The 8-hydroxy-5-deazaflavin-dependent NADP super(+) reductase from Methanococcus vannielii) was examined for its ability to catalyze the reduction of a number of 5-deazaflavin analogues of the natural cofactor. Comparison of the kinetic constants revealed certain substrate structure-reactivity relationships for the enzyme. The basic heterocyclic system of the natural cofactor 2,4-dioxopyrimido(4,5-b)quinoline was shown to be the minimum structural requirement since neither riboflavin nor 1,5-dideazariboflavin was reduced by the enzyme. The N-10 aside chain of the natural cofactor was shown not to be essential since the enzyme could reduce 8-hydroxy-2,4-dioxopyrimido(4,5-b)quinoline. The study also indicated that there are some steric constraints at C-8 and C-7 with respect to interaction of the cofactor with the enzyme. JF - Biochemistry (Washington) AU - Yamazaki, S AU - Tsai, L AU - Stadtman, T C AD - NHLBI, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 934 EP - 939 VL - 21 IS - 5 SN - 0006-2960, 0006-2960 KW - 8-hydroxy-5-deazaflavin KW - Methanococcus vannielii KW - NADP super(+) reductase KW - analogs KW - substrate specificity KW - Microbiology Abstracts B: Bacteriology KW - J 02728:Enzymes KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15463222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Analogues+of+8-Hydroxy-5-Deazaflavin+Cofactor%3A+Relative+Activity+as+Substrates+for+8-Hydroxy-5-Deazaflavin-Dependent+NADP+super%28%2B%29+Reductase+From+Methanococcus+vannielii%29.&rft.au=Yamazaki%2C+S%3BTsai%2C+L%3BStadtman%2C+T+C&rft.aulast=Yamazaki&rft.aufirst=S&rft.date=1982-01-01&rft.volume=21&rft.issue=5&rft.spage=934&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - substrate specificity ER - TY - JOUR T1 - Cell-Free Translation and Partial Characterization of Proenkephalin Messenger RNA From Bovine Striatum. AN - 15450145; 265124 AB - The biosynthesis of the primary precursor of the enkephalins (proenkephalin) was investigated by cell-free translation of bovine striatum poly-adenylated RNA. super(35)S-Labeled proteins encoded by striatum mRNA were digested with trypsin and carboxypeptidase B, and released ( super(35)S) Met-enkephalin was identified by immunoprecipitation and high-performance liquid chromatography. The apparent molecular weight of putative proenkephalin synthesized in cell-free systems was found to be M sub(r) 31,000 plus or minus 1000. Digestion of cell-free translated super(3)H-labeled proteins of M sub(r) 31,000 plus or minus 3000 yielded both ( super(3)H)Met-enkephalin and ( super(3)H)Leu-enkephalin. Putative proenkephalin mRNA of striatum was found to be 1450 plus or minus 200 nucleotides in length. JF - Biochemical and Biophysical Research Communications AU - Dandekar, S AU - Sabol, S L AD - Lab. Biochem. Genet., NHLBI, Bldg. 36, Room IC-06, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 67 EP - 74 VL - 105 IS - 1 SN - 0006-291X, 0006-291X KW - brain KW - cattle KW - cell-free system KW - characterization KW - mRNA KW - proenkephalin KW - purification KW - translation KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - N 14561:ROLE AS A MESSENGER KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15450145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Cell-Free+Translation+and+Partial+Characterization+of+Proenkephalin+Messenger+RNA+From+Bovine+Striatum.&rft.au=Dandekar%2C+S%3BSabol%2C+S+L&rft.aulast=Dandekar&rft.aufirst=S&rft.date=1982-01-01&rft.volume=105&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - purification; brain; cell-free system; mRNA ER - TY - JOUR T1 - Carcinogenesis by Isomers of N-Nitroso-3,5-Dimethylpiperidine. AN - 15449357; 264261 AB - The cis- and trans-isomers of N-nitroso-3,5-dimethylpiperidine were administered separately in drinking water solution to groups of 20 female F344 rats for 50 weeks. The concentrations of the solutions were 0.72 mM for the cis-isomer and 0.14 mM for the trans-isomer. In both groups the animals died with tumors of the upper gastrointestinal (Gl) tract, mainly carcinomas of the esophagus, at about the same time. A third group of animals was given a mixture of the two isomers in the ratio of 5 cis:1 trans, and these animals died more rapidly with the same upper Gl tumors. The trans-isomer appeared to be a more potent carcinogen than the cis-isomer. The 3,5-dimethyl derivative is a less potent carcinogen than nitrosopiperidine. JF - Journal of the National Cancer Institute AU - Lijinsky, W AU - Reuber, MD AU - Singer, S S AU - Singer, G M AD - Chem. Carcinog. Program, NCI-Frederick Cancer Res. Facil., Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 989 EP - 992 VL - 68 IS - 6 SN - 0027-8874, 0027-8874 KW - isomers KW - N-nitroso-3,5-dimethylpiperidine KW - rats KW - Toxicology Abstracts KW - gastrointestinal tract KW - tumorigenesis KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15449357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Carcinogenesis+by+Isomers+of+N-Nitroso-3%2C5-Dimethylpiperidine.&rft.au=Lijinsky%2C+W%3BReuber%2C+MD%3BSinger%2C+S+S%3BSinger%2C+G+M&rft.aulast=Lijinsky&rft.aufirst=W&rft.date=1982-01-01&rft.volume=68&rft.issue=6&rft.spage=989&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - tumorigenesis; gastrointestinal tract ER - TY - JOUR T1 - Modulation of the Immune Response to Lipopolysaccharide. AN - 15449020; 262715 AB - Mice given a single optimally immunogenic dose (20 mu g) of bacterial LPS make an antibody response that is characterized by cyclic (oscillatory) patterns. This kinetic pattern is dose, as well as mouse strain dependent. LPS can induce a secoundary response in BALB/c mice that is also cyclic, although it differs in amplitude, as well as periodicity from a primary response. To rule out the involvement of B cell mitogenic activity of LPS in the expression of such cyclic patterns, the responses produced by both C3H/HeN and C3H/HeJ mice to a single injection of LPS were compared; the latter do not give B cell proliferative responses to LPS and also have been reported to give low LPS-specific responses in vivo. Both strains gave an oscillatory kinetic pattern. By contrast, BALB/c nu/nu mice given an optimal immunogenic dose of LPS (2 mu g) do not present a cyclic immune response. This indicates that mature T cells are required for the generation of an oscillatory anti-LPS response. JF - Journal of Immunology AU - Hiernaux, J R AU - Baker, P J AU - Delisi, C AU - Rudbach, JA AD - Lab. Microbial Immunity, Natl. Inst. Allergy & Infectious Dis., National Institutes of Health, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 1054 EP - 1058 VL - 128 IS - 3 SN - 0022-1767, 0022-1767 KW - characterization KW - lipopolysaccharides KW - mice KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - bacteria KW - immune response KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15449020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Modulation+of+the+Immune+Response+to+Lipopolysaccharide.&rft.au=Hiernaux%2C+J+R%3BBaker%2C+P+J%3BDelisi%2C+C%3BRudbach%2C+JA&rft.aulast=Hiernaux&rft.aufirst=J&rft.date=1982-01-01&rft.volume=128&rft.issue=3&rft.spage=1054&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - bacteria; immune response ER - TY - JOUR T1 - Equilibrium Folding and Unfolding Pathways for a Model Protein. AN - 15448893; 264369 AB - The folding-unfolding process of reduced bovine pancreatic trypsin inhibitor was investigated with an idealized model employing approximate free energies. The specific details are as follows: (1) Folding begins with the appearance of nativelike medium-range contacts at a beta -turn and at the alpha -helix. (2) These grow to include the native pair of interacting beta -strands. This state includes intact regular secondary conformations, as well as the interstrand sheet contacts, and corresponds to an activated state with the highest free energy on the pathway. (3) Additional native-long-range contacts are completely formed either toward the amino terminus or toward the carboxyl terminus. (4) In a final step, the missing contacts appear. Although these folding pathways for this model are not consistent with experimental reports, it does indicate multiple folding pathways. JF - Biopolymers AU - Miyazawa, S AU - Jernigan, R L AD - Lab. Mathematical Biol., DCBD, NCI, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 1333 EP - 1363 VL - 21 IS - 7 SN - 0006-3525, 0006-3525 KW - folding KW - mathematical models KW - trypsin inhibitor KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15448893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biopolymers&rft.atitle=Equilibrium+Folding+and+Unfolding+Pathways+for+a+Model+Protein.&rft.au=Miyazawa%2C+S%3BJernigan%2C+R+L&rft.aulast=Miyazawa&rft.aufirst=S&rft.date=1982-01-01&rft.volume=21&rft.issue=7&rft.spage=1333&rft.isbn=&rft.btitle=&rft.title=Biopolymers&rft.issn=00063525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Activation of an NAD: Arginine ADP-Ribosyltransferase by Histone. AN - 15448515; 264340 AB - An ADP-ribosyltransferase from turkey erythrocytes which utilizes proteins and low molecular weight guanidino compounds such as arginine and agmatine as ADP-ribose acceptors was stimulated by histones. Histones decreased the apparent K sub(m) values for arginine methyl ester and agmatine and increased the stability of the transferase to thermal denaturation. Activation of the transferase by histones was rapid, with a minimal delay observed upon addition of histones to a histone-free assay. Activation by histones was reversed upon dilution of a sample containing histones into an assay mix free of histone. In the absence of histone, the transferase existed as a rapidly sedimenting species; in the presence of histone, the transferase sedimented as a protomer. JF - Journal of Biological Chemistry AU - Moss, J AU - Stanley, S J AU - Osborne, JC Jr AD - Lab. Cell. Metabolism, NHLBI, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 1660 EP - 1663 VL - 257 IS - 4 SN - 0021-9258, 0021-9258 KW - ADP-ribosyltransferase KW - activation KW - erythrocytes KW - histones KW - turkeys KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15448515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Activation+of+an+NAD%3A+Arginine+ADP-Ribosyltransferase+by+Histone.&rft.au=Moss%2C+J%3BStanley%2C+S+J%3BOsborne%2C+JC+Jr&rft.aulast=Moss&rft.aufirst=J&rft.date=1982-01-01&rft.volume=257&rft.issue=4&rft.spage=1660&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Quantitation of Aromatic Residues in Proteins: Model Compounds for Second-Derivative Spectroscopy. AN - 15445406; 261128 AB - The authors describe a method for the simultaneous quantitation of the aromatic amino acids in purified proteins. Second-derivative ultraviolet spectroscopy is used coupled with a statistically weighted multicomponent analysis. Use of the second derivative virtually eliminated interference from light scattering and from cystine. Empirical selection of model compounds obviated the problem of wavelength shifts. The models are N-acetylphenylalanine ethyl ester in 6 M guanidine for phenylalanine, N-acetyltyrosine ethyl ester in 55% methanol for tyrosine, and mellitin in 6 M guanidine for tryptophan. This method permits accurate, rapid quantitation of phenylalanine, tyrosine, and tryptophan in intact, denatured proteins. JF - Biochemistry (Washington) AU - Levine, R L AU - Federici, M M AD - Lab. Biochem., NHLBI, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 2600 EP - 2606 VL - 21 IS - 11 SN - 0006-2960, 0006-2960 KW - U.V. spectroscopy KW - amino acids KW - aromatic KW - assays KW - methodology KW - proteins KW - residues KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15445406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Quantitation+of+Aromatic+Residues+in+Proteins%3A+Model+Compounds+for+Second-Derivative+Spectroscopy.&rft.au=Levine%2C+R+L%3BFederici%2C+M+M&rft.aulast=Levine&rft.aufirst=R&rft.date=1982-01-01&rft.volume=21&rft.issue=11&rft.spage=2600&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Molecular Interaction Between Simian Virus 40 DNA and Escherichia coli RNA Polymerase. Mapping of the Initiation Sites on Supercoiled and Linear DNA. AN - 15427462; 242364 AB - A detailed map of the initiation sites recognized by the Escherichia coli RNA polymerase (holoenzyme) on simian virus 40 (SV40) DNA has been constructed. An approach is described in order to compare the sites recognized on supercoiled as well as relaxed linear DNA. JF - Journal of Biological Chemistry AU - Lavialle, C AU - Reuveni, Y AU - Thoren, M AU - Salzman, N P AD - Lab. Biol. Viruses, NIAID, NIH, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 1549 EP - 1557 VL - 257 IS - 3 SN - 0021-9258, 0021-9258 KW - DNA KW - Escherichia coli KW - RNA polymerase KW - SV40 KW - substrate specificity KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - N 14721:RNA polymerases KW - J 02726:RNA and ribosomes KW - N 14651:Virus & phage infections KW - G 07313:Viruses KW - G 07320:Bacterial genetics KW - V 22044:Viral nucleic acid synthesis & synthesis of virus-coded proteins KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15427462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Molecular+Interaction+Between+Simian+Virus+40+DNA+and+Escherichia+coli+RNA+Polymerase.+Mapping+of+the+Initiation+Sites+on+Supercoiled+and+Linear+DNA.&rft.au=Lavialle%2C+C%3BReuveni%2C+Y%3BThoren%2C+M%3BSalzman%2C+N+P&rft.aulast=Lavialle&rft.aufirst=C&rft.date=1982-01-01&rft.volume=257&rft.issue=3&rft.spage=1549&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - substrate specificity; DNA ER - TY - JOUR T1 - Characterization of Two Tetracycline Resistance Determinants in Streptococcus faecalis JH1. AN - 15424690; 240532 AB - S. faecalis strain JH1 harbors two conjugative plasmids: pJH1, an R plasmid mediating resistance to kanamycin, streptomycin, gentamicin, erythromycin, and tetracycline, and pJH2, a hemolysin-bacteriocin plasmid. Studies of plasmid-cured derivatives of strain JH1 and of transconjugants obtained after mixed incubation of JH1 with the plasmid-free S. faecalis strain JH2-2 revealed the presence of two tetracycline resistance determinants in strain JH1. One determinant mediated consitutive resistance to 40 mu g of tetracycline per ml and was associated with plasmid pJH1. The second determinant, either on the chromosome of strain JH1 or on an undetectable plasmid, was inducible by tetracycline and enabled the host strain, in the absence of pJH1, to grow in the presence of 80 mu g of tetracycline per ml. One transconjugant, strain DL172, was resistant to 80 mu g of tetracycline per ml, sensitive to kanamycin, streptomycin, and erythromycin, and hemolytic in the presence, but not in the absence, of tetracycline. A single plasmid, pDL172, from this strain consisted of plasmid pJH2 and a 17.8-kilobase segment of DNA homologous to total cell DNA from strain JH1 but did not contain plasmid pJH1. Whether the addition of heterologous DNA to plasmid pJH2 occurred by translocation of 1 17.8-kilobase tetracycline resistance transposon or by classical recombination with pJH2 has not been determined. JF - Journal of Bacteriology AU - LeBlanc, D J AU - Lee, L N AD - Lab. Mol. Microbiol., N.I.A.I.D., Fort Detrick, Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 835 EP - 843 VL - 150 IS - 2 SN - 0021-9193, 0021-9193 KW - plasmid JH1 KW - determinants KW - Streptococcus faecalis KW - tetracycline KW - Microbiology Abstracts B: Bacteriology KW - antibiotic resistance KW - plasmids KW - J 02760:Plasmids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15424690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Characterization+of+Two+Tetracycline+Resistance+Determinants+in+Streptococcus+faecalis+JH1.&rft.au=LeBlanc%2C+D+J%3BLee%2C+L+N&rft.aulast=LeBlanc&rft.aufirst=D&rft.date=1982-01-01&rft.volume=150&rft.issue=2&rft.spage=835&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - plasmids; antibiotic resistance ER - TY - JOUR T1 - Effects of Organic Acids on Tubulin Polymerization and Associated Guanosine 5'-Triphosphate Hydrolysis. AN - 15415819; 232249 AB - The authors have examined the effects of a number of organic anions, which stabilize tubulin, on tubulin polymerization, associated GTP hydrolysis, and polymer morphology. Only 2-(N-morpholino)ethanesulfonate induced formation of structures with the morphology of microtubules. With glutamate, fructose 1,6-bisphosphate, piperazine-N-N'-bis(2-ethanesulfonate), glutarate, and glucose 1-phosphate, the predominant structures formed were sheets of parallel protofilaments rather than microtubules. Creatine phosphate induced the formation of clusters of rings. GTP hydrolysis was closely coupled to polymerization only with glutamate. With creatine phosphate, there was minimal GTP hydrolysis. With all other organic anions, GTP hydrolysis substantially exceeded polymerization at all time points, with the onset of hydrolysis significantly preceding the onset of turbidity development. All anion-induced reactions-were temperature dependent and cold reversible, but only the creatine phosphate induced reaction was not inhibited by GDP, CA super(2+), or colchicine and did not require GTP. JF - Biochemistry (Washington) AU - Hamel, E AU - del Campo, AA AU - Lowe, M C AU - Waxman, P G AU - Lin, C M AD - Lab. Med. Chem. & Biol., NCI, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 503 EP - 509 VL - 21 IS - 3 SN - 0006-2960, 0006-2960 KW - GTP KW - acids KW - brain KW - cattle KW - effects on KW - hydrolysis KW - organic compounds KW - polymerization KW - tubulin KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15415819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Effects+of+Organic+Acids+on+Tubulin+Polymerization+and+Associated+Guanosine+5%27-Triphosphate+Hydrolysis.&rft.au=Hamel%2C+E%3Bdel+Campo%2C+AA%3BLowe%2C+M+C%3BWaxman%2C+P+G%3BLin%2C+C+M&rft.aulast=Hamel&rft.aufirst=E&rft.date=1982-01-01&rft.volume=21&rft.issue=3&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Mortality in Women Treated for Hyperthyroidism. AN - 15401540; 226478 AB - To evaluate the late effects of exposure to radioiodine ( super(131)I), a retrospective cohort study was conducted of women treated for hyperthyroidism at the Mayo Clinic, Rochester, Minnesota, from 1946 through 1964. Cause of death was determined in 1005 women treated with super(131)I and in 2141 women surgically treated. No increased risk of total mortality was observed for the super(131)I-treated women. There were no increased risks for the major causes of mortality (cancer, cardiovascular-renal disease or cerebrovascular lesions) in the super(131)I-treated women; in addition, there were no increased risks for site-specific cancer mortality. Several hypotheses are presented to suggest reasons for the lack of an association between super(131)I exposure and increased cancer mortality. JF - American Journal of Epidemiology AU - Hoffman, DA AU - McConahey, WM AU - Diamond, EL AU - Kurland, L T AD - Environ. Epidemiol. Branch, NCI, Rm. 3C-07, Landow Bldg., Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 243 EP - 254 VL - 115 IS - 2 SN - 0002-9262, 0002-9262 KW - relationship KW - iodine-131 KW - Toxicology Abstracts KW - mortality KW - man KW - case surveys KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15401540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Mortality+in+Women+Treated+for+Hyperthyroidism.&rft.au=Hoffman%2C+DA%3BMcConahey%2C+WM%3BDiamond%2C+EL%3BKurland%2C+L+T&rft.aulast=Hoffman&rft.aufirst=DA&rft.date=1982-01-01&rft.volume=115&rft.issue=2&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - mortality; case surveys; man ER - TY - JOUR T1 - Caffeine Inhibits DNA Polymerase I From Escherichia coli : Studies in vitro . AN - 15399012; 226606 AB - Caffeine inhibits the activity of DNA polymerase I (E. coli ) and its proteolytic large fragment in in vitro DNA replication system. DNA polymerase from Micrococcus luteus is also equally inhibited by caffeine. The extent of inhibition was more with the activated adenovirus, T sub(4) and calf thymus DNA than with synthetic DNA template-primers. Results obtained from time-course studies indicated that caffeine inhibition reached maximum by 30 min of incubation. Enzyme kinetic studies showed that inhibition was competitive with respect to DNA template. JF - Carcinogenesis AU - Balachandran, R AU - Srinivasan, A AD - Lab. Cell. Mol. Biol., NCI, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 151 EP - 153 VL - 3 IS - 2 SN - 0143-3334, 0143-3334 KW - DNA polymerase I KW - Escherichia coli KW - Micrococcus luteus KW - caffeine KW - inhibition KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - N 14722:DNA polymerases KW - J 02728:Enzymes KW - G 07320:Bacterial genetics KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15399012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Caffeine+Inhibits+DNA+Polymerase+I+From+Escherichia+coli+%3A+Studies+in+vitro+.&rft.au=Balachandran%2C+R%3BSrinivasan%2C+A&rft.aulast=Balachandran&rft.aufirst=R&rft.date=1982-01-01&rft.volume=3&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Different Patterns of Benzo(a)pyrene Metabolism of Purified Cytochromes P-450 From Methylcholanthrene, beta -Naphthoflavone and Phenobarbital Treated Rats. AN - 15398770; 226405 AB - An improved high-pressure liquid chromatography system was used to analyze the amount of benzo(a)pyrene metabolites formed in reconstituted microsomal mixed-function oxidase systems containing different cytochromes P-450. JF - Carcinogenesis AU - Gelboin, H V AU - Gozukara, E M AU - Guengerich, F P AU - Miller, H AD - Lab. Mol. Carcinogenesis, NCI, NIH, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 129 EP - 133 VL - 3 IS - 2 SN - 0143-3334, 0143-3334 KW - benzo(a)pyrene KW - cytochrome P-450 KW - Toxicology Abstracts KW - microsomes KW - metabolism KW - analysis KW - X 24190:Polycyclic hydrocarbons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15398770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Different+Patterns+of+Benzo%28a%29pyrene+Metabolism+of+Purified+Cytochromes+P-450+From+Methylcholanthrene%2C+beta+-Naphthoflavone+and+Phenobarbital+Treated+Rats.&rft.au=Gelboin%2C+H+V%3BGozukara%2C+E+M%3BGuengerich%2C+F+P%3BMiller%2C+H&rft.aulast=Gelboin&rft.aufirst=H&rft.date=1982-01-01&rft.volume=3&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - analysis; metabolism; microsomes ER - TY - JOUR T1 - Mutagenicity of N-Hydroxy-2-Acetylaminofluorene and N-Hydroxyphenacetin and Their Respective Deacetylated Metabolites in Nitroreductase Deficient Salmonella TA98FR and TA100FR. AN - 15398177; 226809 AB - The mutagenicity of N-hydroxy-2-acetylaminofluorene and N-hydroxyphenacetin and their respective deacetylated metabolites, N-hydroxy-2-aminofluorene and 2-nitrosofluorene, and N-hydroxyphenetidine and rho -nitrosophenetole was determined in nitroreductase deficient Salmonella tester strains TA98FR and TA100FR. JF - Carcinogenesis AU - Wirth, P J AU - Alewood, P AU - Calder, I AU - Thorgeirsson, S S AD - Biochem. Pharmacol. Sect., Lab. Chem. Pharmacol., Div. Cancer Treatment, NCI, NIH, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 167 EP - 170 VL - 3 IS - 2 SN - 0143-3334, 0143-3334 KW - metabolites KW - N-hydroxyacetylaminofluorene KW - N-hydroxyphenacetin KW - Genetics Abstracts; Toxicology Abstracts KW - mutagenicity testing KW - X 24221:Toxicity testing KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15398177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Mutagenicity+of+N-Hydroxy-2-Acetylaminofluorene+and+N-Hydroxyphenacetin+and+Their+Respective+Deacetylated+Metabolites+in+Nitroreductase+Deficient+Salmonella+TA98FR+and+TA100FR.&rft.au=Wirth%2C+P+J%3BAlewood%2C+P%3BCalder%2C+I%3BThorgeirsson%2C+S+S&rft.aulast=Wirth&rft.aufirst=P&rft.date=1982-01-01&rft.volume=3&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - mutagenicity testing ER - TY - JOUR T1 - Glycoproteins of Friend Murine Leukemia Virus: Separation and NH sub(2)-Terminal Amino Acid Sequences of gp69 and gp71. AN - 15397430; 226344 AB - The NH sub(2)-terminal amino acid sequences (initial 23 residues) of Friend murine leukemia virus gp71 and gp69 were determined and found to be different but highly related. Friend murine leukemia virus gp71 differed from Rauscher murine leukemia virus gp70 in only one position. Friend murine leukemia virus gp69 showed similar to 41% homology to these glycoproteins but lacked the glycosylation site (sequon) occurring at position 12 in Rauscher murine leukemia virus gp70. JF - Journal of Virology AU - Oroszlan, S AU - Linder, D AU - Stirm, S AU - Schneider, J AU - Hunsmann, G AU - Smythers, G AD - Biol. Carcinogenesis Prog., Frederick Cancer Res. Fac., NCI, Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 352 EP - 355 VL - 42 IS - 1 SN - 0022-538X, 0022-538X KW - Friend leukemia virus KW - N-terminus KW - amino acid sequence KW - comparison KW - glycoproteins KW - purification KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - A 01002:Acids, amino acids, peptides & proteins KW - V 22032:Viral proteins KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15397430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Glycoproteins+of+Friend+Murine+Leukemia+Virus%3A+Separation+and+NH+sub%282%29-Terminal+Amino+Acid+Sequences+of+gp69+and+gp71.&rft.au=Oroszlan%2C+S%3BLinder%2C+D%3BStirm%2C+S%3BSchneider%2C+J%3BHunsmann%2C+G%3BSmythers%2C+G&rft.aulast=Oroszlan&rft.aufirst=S&rft.date=1982-01-01&rft.volume=42&rft.issue=1&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - glycoproteins; amino acid sequence; purification ER - TY - CONF T1 - Ionizing Radiation and Health. AN - 15371830; 193521 AB - Although ionizing radiation has probably been the subject of more biomedical research than any other environmental agent, and its effects on human health may be better known than those of most, if not all, environmental agents, its significance for human health nevertheless remains highly controversial. This is because the chief practical interest in radiation concerns effects at low doses where risks are apparently too small to be readily observed and theory is not strong enough to permit confident extrapolation from the fairly stable estimates of risk at high doses. In this article the author attempts to specify the limits of what we know about the late-appearing somatic effects of ionizing radiation on man, highlighting the uncertainties and the unresolved issues. JF - American Scientist AU - Beebe, G W Y1 - 1982 PY - 1982 DA - 1982 SP - 35 EP - 44 VL - 70 IS - 1 KW - risk assessment KW - dosimetry KW - Health & Safety Science Abstracts; Pollution Abstracts KW - pathology KW - ionizing radiation KW - public health KW - H SM7.3:HAZARD DETERMINATION KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15371830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Scientist&rft.atitle=Ionizing+Radiation+and+Health.&rft.au=Beebe%2C+G+W&rft.aulast=Beebe&rft.aufirst=G&rft.date=1982-01-01&rft.volume=70&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=American+Scientist&rft.issn=00030996&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Pyrethroids: Involvement of sodium channels in effects on inositol phosphate formation in guinea pig synaptoneurosomes. AN - 15320084; 2088505 AB - The effects of pyrethroids were studied on phosphoinositide breakdown in guinea pig synaptoneurosomes. Similar to other agents that activate voltage-dependent sodium channels, type I and type II pyrethroids stimulated phosphoinositide breakdown. Type II pyrethroids, like deltamethrin and fenvalerate, were more potent and, at least for deltamethrin, more efficacious than type I pyrethroids, like allethrin, resmethrin and permethrin. The effects of type II pyrethroids could be partially inhibited by the sodium channel blocker tetrodotoxin. Type II pyrethroids appear to stimulate phosphoinositide breakdown in synaptoneurosomes in a manner analogous to other sodium channel agents, while type I pyrethroids elicit phosphoinositide breakdown by a different mechanism, probably not involving sodium channels. JF - Brain Research AU - Gusovsky, F AU - Secunda, SI AU - Daly, J W AD - Build. 8, Rm. 1A-15, NIDDK, NIH, Bethesda, MD 20892, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 72 EP - 78 VL - 492 IS - 1-2 SN - 0006-8993, 0006-8993 KW - pyrethroids KW - effects on KW - metabolism KW - role KW - channels KW - guinea-pigs KW - phosphoinositides KW - sodium KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - synaptosomes KW - X 24135:Biochemistry KW - N3 11070:Neurochemistry and cellular biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15320084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Pyrethroids%3A+Involvement+of+sodium+channels+in+effects+on+inositol+phosphate+formation+in+guinea+pig+synaptoneurosomes.&rft.au=Gusovsky%2C+F%3BSecunda%2C+SI%3BDaly%2C+J+W&rft.aulast=Gusovsky&rft.aufirst=F&rft.date=1982-01-01&rft.volume=492&rft.issue=1-2&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - synaptosomes ER - TY - JOUR T1 - High-performance liquid chromatography-mass spectrometry of triazine herbicides AN - 13887138; S198207046 AB - The possibility of using high-performance liquid chromatography combined with mass spectrometry for the determination of 5 classes of triazine weedkillers was investigated, and the results are summarized and discussed. JF - Journal of Chromatography AU - Parker, CE AU - Haney, CA AU - Harvan, D J AU - Hass, J R AD - National Institute of Environmental Health Sciences, U.S.A. Y1 - 1982 PY - 1982 DA - 1982 SP - 77 EP - 96 VL - 242 IS - 1 SN - 0021-9673, 0021-9673 KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13887138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography&rft.atitle=High-performance+liquid+chromatography-mass+spectrometry+of+triazine+herbicides&rft.au=Parker%2C+CE%3BHaney%2C+CA%3BHarvan%2C+D+J%3BHass%2C+J+R&rft.aulast=Parker&rft.aufirst=CE&rft.date=1982-01-01&rft.volume=242&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography&rft.issn=00219673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Lead exposure, begun in utero, decreases renin and angiotensin II in adult rats. AN - 13880127; 736645 AB - Male rats were exposed continuously to Pb in utero and after birth by giving their mothers, during pregnancy and lactation, drinking water containing 0, 5, or 25 ppm Pb (as Pb acetate) and then continuing this regimen after weaning for approximately 5 months. At the time of sacrifice (5 months) the 5- and 25-ppm groups had mean blood Pb concentrations of 5.6 and 18.2 mu g/dl, respectively. Rats exposed to 25 ppm manifested a significant decrease in basal plasma renin activity (PRA) but a significant increase in PRA during stimulation of renin release by acute volume depletion. In this latter state, the ratio of angiotensin II to PRA was significantly reduced in the 25-ppm group. Groups exposed to 5 and 25 ppm both had significant decreases in renal renin concentration. JF - Proceedings of the Society for Experimental Biology and Medicine AU - Victery, W AU - Vander, AL AU - Markel, H AU - Katzman, L AU - Shulak, J M AU - Germain, C AD - NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 63 EP - 67 VL - 170 IS - 1 SN - 0037-9727, 0037-9727 KW - blood levels KW - effects on KW - rats KW - lead acetate KW - renin KW - angiotensin KW - Toxicology Abstracts KW - intrauterine exposure KW - X 24165:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13880127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Society+for+Experimental+Biology+and+Medicine&rft.atitle=Lead+exposure%2C+begun+in+utero%2C+decreases+renin+and+angiotensin+II+in+adult+rats.&rft.au=Victery%2C+W%3BVander%2C+AL%3BMarkel%2C+H%3BKatzman%2C+L%3BShulak%2C+J+M%3BGermain%2C+C&rft.aulast=Victery&rft.aufirst=W&rft.date=1982-01-01&rft.volume=170&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Society+for+Experimental+Biology+and+Medicine&rft.issn=00379727&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - intrauterine exposure ER - TY - JOUR T1 - Components of variation in lead , cadmium, copper and zinc concentration in home drinking water: the Seattle study of trace metal exposure AN - 13864252; 198301025 AB - Variation in trace metal concentrations in water samples at different times from the same home was investigated by open duplicate and blind duplicate determinations, samples split between two laboratories and samples collected from the same homes several months apart. Detailed analysis of the results suggests that most of the variation is due to real changes in metal concentration and that improvement of methodology would have only a small effect. JF - Environmental Research AU - Sharrett, A R AU - Orheim, R M AU - Carter AU - Hyde, JE AU - Feinleib, M AD - National Heart, Lung and Blood Institute, Bethesda, Md. Y1 - 1982 PY - 1982 DA - 1982 SP - 476 EP - 498 VL - 28 IS - 2 SN - 0013-9351, 0013-9351 KW - Pb KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13864252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Components+of+variation+in+lead+%2C+cadmium%2C+copper+and+zinc+concentration+in+home+drinking+water%3A+the+Seattle+study+of+trace+metal+exposure&rft.au=Sharrett%2C+A+R%3BOrheim%2C+R+M%3BCarter%3BHyde%2C+JE%3BFeinleib%2C+M&rft.aulast=Sharrett&rft.aufirst=A&rft.date=1982-01-01&rft.volume=28&rft.issue=2&rft.spage=476&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Phthalate ester testing in the National Toxicology Programme's environmental mutagenesis test development programme AN - 13864060; 198301422 AB - Results are presented from experiments on the mutagenicity of a series of 20 phthalate esters and related organic compounds, using Salmonella typhimurium as the test organism. None of the chemicals tested showed any mutagenic activity. JF - Environmental Health Perspectives AU - Zeiger, E AU - Haworth, S AU - Speck, W AU - Mortelmans, K AD - National Institute of Environmental Health Sciences, N.C. Y1 - 1982 PY - 1982 DA - 1982 SP - 99 EP - 101 VL - 45 SN - 0091-6765, 0091-6765 KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13864060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Phthalate+ester+testing+in+the+National+Toxicology+Programme%27s+environmental+mutagenesis+test+development+programme&rft.au=Zeiger%2C+E%3BHaworth%2C+S%3BSpeck%2C+W%3BMortelmans%2C+K&rft.aulast=Zeiger&rft.aufirst=E&rft.date=1982-01-01&rft.volume=45&rft.issue=&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Daily intake of lead , cadmium, copper and zinc from drinking water: the Seattle study of trace metal exposure AN - 13861575; 198301024 AB - Lead , cadmium, copper and zinc concentrations were measured in both standing and running samples taken from drinking water in a range of Seattle homes. Metal concentrations were related to type of pipe (copper or galvanized), length of pipe, age of house and source of supply. Daily intakes of trace metals were calculated for men, women and children based on reported water consumption and are detailed in this paper . JF - Environmental Research AU - Sharrett, A R AU - Carter AU - Orheim, R M AU - Feinleib, M AD - National Heart, Lung and Blood Institute, Bethesda, Md. Y1 - 1982 PY - 1982 DA - 1982 SP - 456 EP - 475 VL - 28 IS - 2 SN - 0013-9351, 0013-9351 KW - Pb KW - Pipes (see also conduits, drains, pipelines,sewers) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13861575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Daily+intake+of+lead+%2C+cadmium%2C+copper+and+zinc+from+drinking+water%3A+the+Seattle+study+of+trace+metal+exposure&rft.au=Sharrett%2C+A+R%3BCarter%3BOrheim%2C+R+M%3BFeinleib%2C+M&rft.aulast=Sharrett&rft.aufirst=A&rft.date=1982-01-01&rft.volume=28&rft.issue=2&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Role of calmodulin in the activation of tryptophan hydroxylase. AN - 13641794; 531857 AB - Tryptophan hydroxylase can be activated 2.0- to 2.5-fold in vitro by ATP and Mg super(2+). This apparent phosphorylation effect is not dependent on cyclic nucleotides but is dependent on the presence of calcium. The addition of certain antipsychotic drugs known to bind to calmodulin in a phosphorylation reaction mixture prevents the activation to tryptophan hydroxylase by ATP-Mg super(2+) in a concentration-dependent fashion. External addition of purified calmodulin protects the enzyme from the drug-induced effects. Preparation of calmodulin-free tryptophan hydroxylase by affinity chromatography on fluphenazine-Sepharose 4B yields an enzyme that is no longer activated by ATP-Mg super(2+), whereas the readdition of calmodulin to a calmodulin-free enzyme restores the responsiveness of tryptophan hydroxylase to ATP-Mg super(2+). This restoration is dependent on Ca super(2+). Taken together, these results indicate that the activation of tryptophan hydroxylase by phosphorylating conditions is dependent on both calcium and calmodulin. JF - FED. PROC. AU - Kuhn, D M AU - Lovenberg, W AD - Sect. Bicohem. Pharmacol., Hypertension-Endocrine Branch, NHLBI, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 2258 EP - 2264 VL - 41 IS - 7 SN - 0014-9446, 0014-9446 KW - activation KW - calmodulin KW - tryptophan 5-monooxygenase KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13641794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FED.+PROC.&rft.atitle=Role+of+calmodulin+in+the+activation+of+tryptophan+hydroxylase.&rft.au=Kuhn%2C+D+M%3BLovenberg%2C+W&rft.aulast=Kuhn&rft.aufirst=D&rft.date=1982-01-01&rft.volume=41&rft.issue=7&rft.spage=2258&rft.isbn=&rft.btitle=&rft.title=FED.+PROC.&rft.issn=00149446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Enzymatic activities of the recA protein of Escherichia coli . AN - 13568998; 460036 AB - A review. JF - Biochimie. Paris AU - Weinstock, G M AD - Genet. Eng. Lab., NCI-Frederick Cancer Res. Fac., Frederick, MD 21701, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 611 EP - 616 VL - 64 IS - 8-9 SN - 0300-9084, 0300-9084 KW - DNA repair KW - Escherichia coli KW - kineties KW - recA gene protein KW - reviews KW - role KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - J 02725:DNA KW - N 14100:Reviews KW - G 07320:Bacterial genetics KW - N 14652:DNA repair KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13568998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Biochimie.+Paris&rft.atitle=Enzymatic+activities+of+the+recA+protein+of+Escherichia+coli+.&rft.au=Weinstock%2C+G+M&rft.aulast=Weinstock&rft.aufirst=G&rft.date=1982-01-01&rft.volume=64&rft.issue=8-9&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Biochimie.+Paris&rft.issn=03009084&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - reviews; DNA repair ER - TY - JOUR T1 - Effects of chronic lithium, clorgyline, imipramine, fluphenazine and constant darkness on the alpha -melanotropin content and circadian rhythm in rat brain. AN - 13535934; 433441 AB - The effects of constant darkness, chronic lithium, clorgyline, imipramine and fluphenazine treatment on the content and diurnal rhythm of alpha -MSH in rat forebrain were investigated. The persistence of the alpha -MSH rhythm in constant darkness demonstrated that the rhythm was circadian in nature. Constant darkness increased the 24 h mean alpha -MSH concentration in brain while lithium, fluphenazine and imipramine decreased it. In addition, imipramine and clorgyline delayed the phase of the alpha -MSH circadian rhythm while lithium advanced it. JF - European Journal of Pharmacology AU - O'Donohue, T L AU - Wirz-Justice, A AU - Kafka AU - Naber, D AU - Campbell, I C AU - Wehr, T A AD - Lab. Clin. Sci., NIMH, Build. 10, Rm. 3D-48, Natl. Inst. Health, Bethesda, MD 20205, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 1 EP - 7 VL - 85 IS - 1 SN - 0014-2999, 0014-2999 KW - levels KW - effects on KW - melanotropin KW - rats KW - darkness KW - lithium KW - clorgyline KW - imipramine KW - fluphenazine KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - forebrain KW - drugs KW - circadian rhythms KW - N3 11094:Central nervous system KW - X 24112:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13535934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Pharmacology&rft.atitle=Effects+of+chronic+lithium%2C+clorgyline%2C+imipramine%2C+fluphenazine+and+constant+darkness+on+the+alpha+-melanotropin+content+and+circadian+rhythm+in+rat+brain.&rft.au=O%27Donohue%2C+T+L%3BWirz-Justice%2C+A%3BKafka%3BNaber%2C+D%3BCampbell%2C+I+C%3BWehr%2C+T+A&rft.aulast=O%27Donohue&rft.aufirst=T&rft.date=1982-01-01&rft.volume=85&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - forebrain; circadian rhythms; drugs ER - TY - JOUR T1 - Ototoxicity of kanamycin sulfate and the barriers in the inner ear. AN - 85195799; pmid-6801580 AB - The effect of kanamycin sulfate administered by three routes on the function of the stria vascularis was monitored electrophysiologically in guinea pigs. The three routes were intramuscular injection, perilymphatic perfusion, or endolymphatic perfusion. Neither systemic administration of 500 mg/kg of body weight per day for 7 to 12 days nor perilymphatic perfusion of 10(-3) M kanamycin affected the endocochlear dc potential (EP). However, with perfusion of kanamycin 10(-3) M in the endolymphatic space, the EP declined severely. Moreover, the decline in the EP was greater with higher concentrations of kanamycin in the endolymphatic perfusate. Furosemide given by each of the three routes produced an approximately equal decrease in the EP. The effects of kanamycin on the cells of the stria vascularis and the evidence for the perilymphatic-endolymphatic and blood-cochlear barriers are discussed. JF - Otolaryngology--Head and Neck Surgery AU - Komune, S AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1981 SP - 1013 EP - 1018 VL - 89 IS - 6 SN - 0194-5998, 0194-5998 KW - Cochlea KW - Hair Cells KW - Perfusion KW - Injections, Intramuscular KW - Animal KW - Stria Vascularis KW - Kanamycin KW - Mice KW - Cochlear Microphonic Potentials KW - Furosemide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85195799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Ototoxicity+of+kanamycin+sulfate+and+the+barriers+in+the+inner+ear.&rft.au=Komune%2C+S%3BSnow%2C+J+B&rft.aulast=Komune&rft.aufirst=S&rft.date=1981-11-01&rft.volume=89&rft.issue=6&rft.spage=1013&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Potentiating effects of cisplatin and ethacrynic acid in ototoxicity. AN - 85248088; pmid-7197152 AB - Seven milligrams per kilogram of body weight of cisplatin and 50 mg/kg of body weight of ethacrynic acid were given intravenously to guinea pigs. The threshold for Preyer's reflex, the cochlear microphonics (CM), and the endocochlear dc potential (EP) were measured during a four-day period after the injection. The changes in Preyer's reflex audiometry and the CM were more severe than that of the EP. These changes are greater than those that occur with the administration of each agent independently. The ototoxic interaction seemingly has a greater effect on the hair cells than on the stria vascularis. Baseline and periodic audiometry should be performed when both of these drugs are administered clinically. JF - Archives of Otolaryngology (Chicago, Ill. : 1960) AU - Komune, S AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1981 SP - 594 EP - 597 VL - 107 IS - 10 SN - 0003-9977, 0003-9977 KW - Cochlea KW - Ethacrynic Acid KW - Audiometry KW - Cisplatin KW - Guinea Pigs KW - Animal KW - Ear, External KW - Hearing Loss, Sensorineural KW - Reflex KW - Cochlear Microphonic Potentials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85248088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Otolaryngology+%28Chicago%2C+Ill.+%3A+1960%29&rft.atitle=Potentiating+effects+of+cisplatin+and+ethacrynic+acid+in+ototoxicity.&rft.au=Komune%2C+S%3BSnow%2C+J+B&rft.aulast=Komune&rft.aufirst=S&rft.date=1981-10-01&rft.volume=107&rft.issue=10&rft.spage=594&rft.isbn=&rft.btitle=&rft.title=Archives+of+Otolaryngology+%28Chicago%2C+Ill.+%3A+1960%29&rft.issn=00039977&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Cytotoxic responses to alloantigens in systemic lupus erythematosus. AN - 73990559; 19338096 AB - We have studied the ability of the peripheral mononuclear cells (MNC) from patients with systemic lupus erythematosus (SLE) to generate a cytotoxic (CML) response against alloantigens. CML responses in SLE patients were significantly lower than those of normal individuals. Mixed lymphocyte reaction (MLR) assays conducted in parallel in these patients were decreased but to a lesser extent. Some of the patients exhibited parallel decreases in both CML and MLR tests, while others showed decreased CML responses but normal MLR responses. Optimal CML responses in SLE patients did not occur at a different time point than in the normals. Plasma from most SLE patients tested did not have an effect on CML and MLR responses of normal MNC; the plasma of only one patient consistently decreased the CML of normal cells. Depletion of adherent cells from MNC of SLE patients by Sephadex G-10 fractionation allowed better CML and MLR responses. Low CML responses in patients with SLE were associated with increased disease activity and increased serum DNA binding. No association between MLR responses in SLE patients and any of the above parameters was detected. SLE patients not having received any cytotoxic treatment exhibited the lowest CML responses, while these under treatment or treated in the past had higher, although not normal, responses. MLR responses were not affected by the treatment status of the patients. JF - Journal of clinical immunology AU - Tsokos, G C AU - Balow, J E AD - Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA. Y1 - 1981/10// PY - 1981 DA - October 1981 SP - 208 EP - 216 VL - 1 IS - 4 SN - 0271-9142, 0271-9142 KW - Complement C3 KW - 0 KW - Immunosuppressive Agents KW - Isoantigens KW - Allopurinol KW - 63CZ7GJN5I KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Lymphocyte Activation KW - Allopurinol -- therapeutic use KW - Cyclophosphamide -- therapeutic use KW - Humans KW - Lymphocyte Culture Test, Mixed KW - Cytotoxicity Tests, Immunologic KW - Cell Separation KW - Immunosuppressive Agents -- therapeutic use KW - Complement C3 -- analysis KW - Lupus Erythematosus, Systemic -- immunology KW - Cytotoxicity, Immunologic KW - Lupus Erythematosus, Systemic -- drug therapy KW - Lupus Erythematosus, Systemic -- blood KW - Isoantigens -- immunology KW - Leukocytes, Mononuclear -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73990559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+immunology&rft.atitle=Cytotoxic+responses+to+alloantigens+in+systemic+lupus+erythematosus.&rft.au=Tsokos%2C+G+C%3BBalow%2C+J+E&rft.aulast=Tsokos&rft.aufirst=G&rft.date=1981-10-01&rft.volume=1&rft.issue=4&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+immunology&rft.issn=02719142&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-19 N1 - Date created - 2009-04-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recombinant DNA research; final plan for a program to assess the risks. AN - 75527560; 11655492 JF - Federal register AU - U.S. National Institutes of Health AD - U.S. National Institutes of Health Y1 - 1981/06/10/ PY - 1981 DA - 1981 Jun 10 SP - 30772 EP - 30778 VL - 46 IS - 111 SN - 0097-6326, 0097-6326 KW - DNA, Recombinant KW - 0 KW - Hazardous Substances KW - Bioethics KW - Biomedical and Behavioral Research KW - National Institutes of Health KW - Financial Support KW - Government KW - Federal Government KW - Containment of Biohazards KW - Evaluation Studies as Topic KW - Risk KW - Government Regulation KW - Social Control, Formal KW - National Institutes of Health (U.S.) KW - Risk Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75527560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Recombinant+DNA+research%3B+final+plan+for+a+program+to+assess+the+risks.&rft.au=U.S.+National+Institutes+of+Health&rft.aulast=U.S.+National+Institutes+of+Health&rft.aufirst=&rft.date=1981-06-10&rft.volume=46&rft.issue=111&rft.spage=30772&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1983-09-20 N1 - Date created - 1983-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Isolation and characterization of dexamethasone-resistant mutants from human lymphoid cell line CEM-C7. AN - 73960116; 6965106 AB - Fifty-four independent dexamethasone-resistant clones were isolated from the clonal, glucocorticoid-sensitive human leukemic T-cell line CEM-C7. Resistance to 1 microM dexamethasone was acquired spontaneously at a rate of 2.6 X 10(-5) per cell per generation as determined by fluctuation analysis. After mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), the phenotypic expression time for dexamethasone resistance was determined to be 3 days. Spontaneous acquisition of resistance to 0.1 mM 6-thioguanine appeared to occur at a much slower rate, 1.6 X 10(-6) per cell per generation. However, the expression time after MNNG mutagenesis for this resistant phenotype was greater than 11 days, suggesting that the different rates of acquisition for the two phenotypes measured by fluctuation analysis were the results of the disparate expression times. The mutagens ICR 191 and MNNG were effective in increasing the dexamethasone-resistant fraction of cells in mutagenized cultures; ICR 191 produced a 35.6-fold increase, and MNNG produced an 8.5-fold increase. All the spontaneous dexamethasone-resistant clones contained glucocorticoid receptors, usually less than half of the amount found in the parental clone. They are therefore strikingly different from dexamethasone-resistant clones derived from the mouse cell lines S49 and W7. Dexamethasone-resistant clones isolated after mutagenesis of CEM-C7 contained, on the average, lower concentrations of receptor than did those isolated spontaneously, and one clone contained no detectable receptor. These results are consistent with a mutational origin for dexamethasone resistance in these human cells at a haploid or functionally hemizygous locus. They also suggest that this is a useful system for mutation assay. JF - Molecular and cellular biology AU - Harmon, J M AU - Thompson, E B AD - Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20205. Y1 - 1981/06// PY - 1981 DA - June 1981 SP - 512 EP - 521 VL - 1 IS - 6 SN - 0270-7306, 0270-7306 KW - Mutagens KW - 0 KW - Receptors, Steroid KW - Dexamethasone KW - 7S5I7G3JQL KW - Index Medicus KW - Phenotype KW - Receptors, Steroid -- drug effects KW - Humans KW - Cell Division -- drug effects KW - Drug Resistance KW - Mutagens -- pharmacology KW - Mutation KW - Cell Line KW - Leukemia -- drug therapy KW - Leukemia -- metabolism KW - Dexamethasone -- pharmacology KW - Leukemia -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73960116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Isolation+and+characterization+of+dexamethasone-resistant+mutants+from+human+lymphoid+cell+line+CEM-C7.&rft.au=Harmon%2C+J+M%3BThompson%2C+E+B&rft.aulast=Harmon&rft.aufirst=J&rft.date=1981-06-01&rft.volume=1&rft.issue=6&rft.spage=512&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pediatr. 1967 Apr;70(4):626-31 [5227061] Cell. 1980 Aug;21(1):47-56 [6105925] Mol Pharmacol. 1970 Sep;6(5):500-12 [4318965] Science. 1971 Jan 15;171(3967):189-91 [4395230] Mutat Res. 1973 May;18(2):199-224 [4711931] J Biol Chem. 1974 Apr 25;249(8):2483-8 [4150794] Cell. 1974 Aug;2(4):213-20 [4472165] Cell. 1974 Aug;2(4):221-7 [4370191] Proc Natl Acad Sci U S A. 1974 Oct;71(10):3901-5 [4372597] Cell. 1974 Nov;3(3):221-6 [4434471] Cell. 1974 Nov;3(3):301-6 [4373173] Chem Biol Interact. 1976 Sep;15(1):33-50 [971516] Science. 1977 Aug 19;197(4305):769-71 [70075] Cell. 1977 Jun;11(2):423-30 [560913] Cell. 1977 Jun;11(2):447-54 [408012] Cancer Res. 1977 Oct;37(10):3785-91 [269011] Mutat Res. 1977 Sep;44(3):401-11 [904650] J Supramol Struct. 1977;6(3):325-31 [201807] Mol Cell Endocrinol. 1978 Apr;10(2):193-207 [566227] Proc Natl Acad Sci U S A. 1978 Jul;75(7):3337-40 [277932] Somatic Cell Genet. 1978 Sep;4(5):513-30 [694726] Cancer Res. 1978 Nov;38(11 Pt 2):4251-6 [308841] Cancer Res. 1978 Nov;38(11 Pt 2):4268-72 [279402] Cancer Res. 1978 Nov;38(11 Pt 2):4279-84 [698966] Proc Natl Acad Sci U S A. 1978 Dec;75(12):6130-3 [104300] Cell. 1979 Jan;16(1):1-9 [369702] J Cell Physiol. 1979 Feb;98(2):267-78 [422656] J Cell Physiol. 1979 Jun;99(3):333-41 [457795] Cancer Res. 1979 Oct;39(10):4011-21 [476639] Mol Cell Endocrinol. 1979 Sep;15(3):135-50 [39858] Monogr Endocrinol. 1979;12:357-76 [492175] N Engl J Med. 1980 Jan 24;302(4):198-209 [6985704] Nature. 1980 Jul 31;286(5772):507-10 [6967568] Exp Cell Res. 1970 Apr;60(1):61-77 [5439579] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pathophysiology of the ototoxicity of cis-diamminedichloroplatinum. AN - 85195014; pmid-6787526 AB - The electrophysiologic and histopathologic changes in the inner ear caused by the administration of cis-diamminedichloroplatinum (CP) were studied in guinea pigs. The endocochlear dc potential (EP) gradually decreased after the intravenous injection of CP and reached approximately 0 mV on the fourth day, but the EP did not become negative. The cochlear microphonics also diminished and could not be recorded on the fourth day. The negative potential of the organ of Corti remained in the normal range during the experiment. A large negative summating potential (SP) was observed one day after injection, but the amplitude of the negative SP became small on the second day. Light microscopic examination demonstrated that the outer hair cells are destroyed in the basal turn of the cochlea and are preserved in the upper turns, while the inner hair cells are almost completely preserved in all turns. The stria vascularis was found to be slightly atrophic. Severe collapse of Reissner's membrane was observed in the basal turn. JF - Otolaryngology--Head and Neck Surgery AU - Komune, S AU - Asakuma, S AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1981 SP - 275 EP - 282 VL - 89 IS - 2 SN - 0194-5998, 0194-5998 KW - Cochlea KW - Deafness KW - Cisplatin KW - Guinea Pigs KW - Animal KW - Evoked Potentials, Auditory KW - Organ of Corti KW - Cochlear Microphonic Potentials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85195014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Pathophysiology+of+the+ototoxicity+of+cis-diamminedichloroplatinum.&rft.au=Komune%2C+S%3BAsakuma%2C+S%3BSnow%2C+J+B&rft.aulast=Komune&rft.aufirst=S&rft.date=1981-03-01&rft.volume=89&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Comparative ototoxicity of chloramphenicol and kanamycin with ethacrynic acid. AN - 85254353; pmid-7469887 AB - Chloramphenicol is not ototoxic if administered for systemic effect, but topical applications of it to the middle ear produce severe cochlear toxic effects. Ethacrynic acid potentiates the ototoxicity of aminoglycosides. Guinea pigs were administered chloramphenicol or kanamycin sulfate with ethacrynic acid to compare the ototoxicity of chloramphenicol and ethacrynic acid with the ototoxicity of kanamycin and ethacrynic acid. Preyer's reflex audiometry and measurement of the endocochlear dc potential, the cochlear microphonics, and the negative potential of the organ of Corti indicate that ethacrynic acid does not potentiate the ototoxicity of chloramphenicol. There is not even indirect evidence that the blood-cochlear barrier for chloramphenicol is altered by ethacrynic acid. Assuming that the ototoxicity of chloramphenicol and ethacrynic acid are similar for man and guinea pig, the combination of the administration of chloramphenicol and ethacrynic acid of systemic effect in dosages commonly used clinically should not produce greater ototoxicity than either agent administered alone. JF - Archives of Otolaryngology (Chicago, Ill. : 1960) AU - Beaugard, M E AU - Asakuma, S AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1981 SP - 104 EP - 109 VL - 107 IS - 2 SN - 0003-9977, 0003-9977 KW - Cochlea KW - Chloramphenicol KW - Ethacrynic Acid KW - Comparative Study KW - Auditory Threshold KW - Guinea Pigs KW - Animal KW - Ear KW - Kanamycin KW - Sodium Chloride KW - Drug Synergism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85254353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Otolaryngology+%28Chicago%2C+Ill.+%3A+1960%29&rft.atitle=Comparative+ototoxicity+of+chloramphenicol+and+kanamycin+with+ethacrynic+acid.&rft.au=Beaugard%2C+M+E%3BAsakuma%2C+S%3BSnow%2C+J+B&rft.aulast=Beaugard&rft.aufirst=M&rft.date=1981-02-01&rft.volume=107&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Archives+of+Otolaryngology+%28Chicago%2C+Ill.+%3A+1960%29&rft.issn=00039977&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - CPAPER T1 - A Stochastic Model of Relational Control in Dyadic Interaction T2 - American Sociological Association AN - 61737018; 81S13315 AB - The development of a "working consensus" through negotiation between social actors in a situation of ambiguous normative expectations has been described as a cybernetic process. Reported is a study of the dynamics specific to one kind of negotiation, that of defining rational control. The data fit a model of a third-order Markov process, implying that control direction of a given speech depends on the three speeches before it. A digraph of the transition probabilities from speeches at t, t +1, & t +2, to the speech at t +3 shows that the interaction tends toward competitive symmetry (a series of speeches asserting control) or equivalent symmetry (a series of speeches that neither assert nor give up control). Assertive speeches lead to competitive symmetry, as do submissive speeches. In contrast, neutral speeches decrease the competitive quality of the interaction. JF - American Sociological Association AU - McCarrick, Anne K AU - Manderscheid, Ronald W AU - Rae, Donald S Y1 - 1981///0, PY - 1981 DA - 0, 1981 KW - negotiated consensus KW - relational control, stochastic model, dyadic interaction KW - Negotiation/Negotiations KW - Statistics/Statistical/ Statistically KW - Consensus/Consensual KW - Model/Modeling/Models KW - Stochastic KW - proceeding KW - 0161: methodology and research technology; models: mathematical & other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61737018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Sociological+Association&rft.atitle=A+Stochastic+Model+of+Relational+Control+in+Dyadic+Interaction&rft.au=McCarrick%2C+Anne+K%3BManderscheid%2C+Ronald+W%3BRae%2C+Donald+S&rft.aulast=McCarrick&rft.aufirst=Anne&rft.date=1981-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Sociological+Association&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-03-10 N1 - Publication note - 1981 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Relationship between carcinogenicity and in vitro metabolism of nitrosomethylethylamine, nitrosomethyl-n-butylamine, and nitrosomethyl-(2-phenylethyl)amine labeled with deuterium in the methyl and alpha -methylene positions. AN - 15526662; 369214 AB - With the use of rat liver preparations, the in vitro microsomal metabolism of methylethylnitrosamine, methyl-n-butylnitrosamine, and methyl(2-phenylethyl)nitrosamine labeled with deuterium in the methyl and alpha -methylene positions has been compared with that of the parent (unlabeled) compounds. The metabolism of the three methylbutylnitrosamines gave results similar to that of the three methylethyl nitrosamines. Except for metabolism of d sub(2)-methylbutylnitrosamine to butyraldehyde, two sets of kinetic constants were found. Approximately equivalent amounts of methylating species were produced from d sub(3)-methylbutylnitrosamine and d sub(0)-methylbutylnitrosamine. JF - Cancer Research AU - Farrelly, J G AU - Stewart, M L AU - Saavedra, JE AU - Lijinsky, W AD - Chem. Carcinog. Program, NCI-Frederick Cancer Res. Fac., Frederick, MD 21701, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 2105 EP - 2109 VL - 42 IS - 6 SN - 0008-5472, 0008-5472 KW - N-nitrosomethyl(2-phenylethyl)amine KW - N-nitrosomethyl-N-butylamine KW - N-nitrosomethylethylamine KW - rats KW - Toxicology Abstracts KW - structure-activity relationships KW - carcinogenicity KW - metabolism KW - microsomes KW - liver KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15526662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Relationship+between+carcinogenicity+and+in+vitro+metabolism+of+nitrosomethylethylamine%2C+nitrosomethyl-n-butylamine%2C+and+nitrosomethyl-%282-phenylethyl%29amine+labeled+with+deuterium+in+the+methyl+and+alpha+-methylene+positions.&rft.au=Farrelly%2C+J+G%3BStewart%2C+M+L%3BSaavedra%2C+JE%3BLijinsky%2C+W&rft.aulast=Farrelly&rft.aufirst=J&rft.date=1981-01-01&rft.volume=42&rft.issue=6&rft.spage=2105&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - carcinogenicity; structure-activity relationships; microsomes; metabolism; liver ER - TY - JOUR T1 - Genetic Analysis of the Major Outer Membrane Proteins of Escherichia coli . AN - 15490332; 261466 AB - In this review, the authors will focus on the major outer membrane proteins of E. coli . The topology, function, regulation, and biosynthesis of these proteins will be discussed in a context of E. coli outer membrane as a system amenable to study by a genetic approach. JF - Annual Review of Genetics AU - Hall, M N AU - Silhavy, T J AD - Cancer Biol. Prog., NCI-Frederick Cancer Res. Cent., Frederick, MD 21701, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 91 EP - 142 VL - 15 SN - 0066-4197, 0066-4197 KW - characterization KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - membrane proteins KW - reviews KW - function KW - genetic analysis KW - outer membranes KW - regulation KW - Escherichia coli KW - topology KW - G 07320:Bacterial genetics KW - J 02727:Amino acids, peptides and proteins KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15490332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Genetics&rft.atitle=Genetic+Analysis+of+the+Major+Outer+Membrane+Proteins+of+Escherichia+coli+.&rft.au=Hall%2C+M+N%3BSilhavy%2C+T+J&rft.aulast=Hall&rft.aufirst=M&rft.date=1981-01-01&rft.volume=15&rft.issue=&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Genetics&rft.issn=00664197&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; reviews; outer membranes; membrane proteins; topology; function; regulation; genetic analysis ER - TY - JOUR T1 - Effect of Phenobarbital Pretreatment on the Toxicity and Metabolism of 2,4-Diaminoanisole. AN - 15459155; 269130 AB - 2,4-Diaminoanisole (2,4-DAA), which has both carcinogenic and mutagenic activities, has been a component of commercial hair dyes. Pretreatment of rats with inducers or inhibitors of the cytochrome P-450 system caused an alteration in the level of protein binding and mutagenicity. Phenobarbital (PB), a broad spectrum microsomal enzyme inducer, has been shown to increase binding of 2,4-DAA to liver and kidney proteins in vitro and in vivo. It was the purpose of this study to investigate the effects of phenobarbital on the acute toxicity, macromolecular binding, disposition and metabolism of 2,4-DAA in rats. JF - Biochemical Pharmacology AU - Ruchirawat, M AU - Grantham, PH AU - Benjamin, T AU - Weisburger, E K AD - Lab. Carcinogen Metab., Dep. Health Human Serv., PHS, NCI, NIH, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 2715 EP - 2718 VL - 30 IS - 19 SN - 0006-2952, 0006-2952 KW - effects on KW - phenobarbiton KW - 2,4-diaminoanisole KW - rats KW - Toxicology Abstracts KW - acute toxicity KW - sedatives KW - metabolism KW - X 24114:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15459155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Pharmacology&rft.atitle=Effect+of+Phenobarbital+Pretreatment+on+the+Toxicity+and+Metabolism+of+2%2C4-Diaminoanisole.&rft.au=Ruchirawat%2C+M%3BGrantham%2C+PH%3BBenjamin%2C+T%3BWeisburger%2C+E+K&rft.aulast=Ruchirawat&rft.aufirst=M&rft.date=1981-01-01&rft.volume=30&rft.issue=19&rft.spage=2715&rft.isbn=&rft.btitle=&rft.title=Biochemical+Pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - acute toxicity; metabolism; sedatives ER - TY - JOUR T1 - Ultraviolet Radiation-Induced Tumors Do Not Arise From a Subpopulation of Ultraviolet-Resistant Cells. AN - 15448799; 264255 AB - This study was designed to determine whether UV-induced tumors have a selective growth advantage in the autochthonous host by virtue of possessing a heritable resistance to UV-induced lethality. Several fibrosarcomas were induced either by repeated exposure of C3H mice to UV radiation from FS40 sunlamps or by subcutaneous injection of C3H mice with a chemical carcinogen (methylcholanthrene). Tissue culture lines of these tumors were tested in vitro for susceptibility to the lethal effects of UV radiation from an FS40 sunlamp. Lethality was assessed by measuring colony formation as a function of increasing dose of radiation. Cells from the UV-induced fibrosarcomas were not more resistant to the lethal effects of UV radiation than cells from methylcholanthrene-induced fibrosarcomas or cells from a nontumorigenic C3H fibroblast cell line. This suggests that UV-induced tumors do no arise from a subpopulation of UV-resistant cells. JF - Photochemistry and Photobiology AU - Fisher AD - Cancer Biol. Prog., NCI-Frederick Cancer Res. Cent., Frederick, MD 21701, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 135 EP - 137 VL - 34 IS - 1 SN - 0031-8655, 0031-8655 KW - role KW - mice KW - Toxicology Abstracts KW - U.V. radiation KW - tumorigenesis KW - resistance KW - skin KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15448799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+Photobiology&rft.atitle=Ultraviolet+Radiation-Induced+Tumors+Do+Not+Arise+From+a+Subpopulation+of+Ultraviolet-Resistant+Cells.&rft.au=Fisher&rft.aulast=Fisher&rft.aufirst=&rft.date=1981-01-01&rft.volume=34&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+Photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - U.V. radiation; resistance; tumorigenesis; skin ER - TY - JOUR T1 - Pott's Disease Following BCG Therapy of Melanoma. AN - 15443075; 258773 AB - The first reported case of a patient with BCG-induced Pott's disease following immunotherapy for melanoma is presented. No signs or symptoms of the disease were detected for 2 1/2 years after therapy. The diagnosis and treatment of this complication of melanoma therapy are discussed. JF - Cancer AU - Strausser, J L AU - Quindlen, E A AD - NCI, NIH, Build. 10 Room 10N116, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 1154 EP - 1156 VL - 48 IS - 5 SN - 0008-543X, 0008-543X KW - bone disease KW - Toxicology Abstracts KW - side effects KW - BCG KW - case reports KW - man KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15443075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Pott%27s+Disease+Following+BCG+Therapy+of+Melanoma.&rft.au=Strausser%2C+J+L%3BQuindlen%2C+E+A&rft.aulast=Strausser&rft.aufirst=J&rft.date=1981-01-01&rft.volume=48&rft.issue=5&rft.spage=1154&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - BCG; side effects; case reports; man ER - TY - JOUR T1 - The Biologic Activity of Mast Cell Granules. III. Purification of Inflammatory Factors of Anaphylaxis (IF-A) Responsible for Causing Late-Phase Reactions. AN - 15442687; 255792 AB - Mast cell degranulation leads to cellular infiltrates in rat, monkey, and human skin. In rodents the infiltrate intially appears within 2 to 8 hr and consists primarily of polymorphonuclear leukocytes. The response persists through 24 to 48 hr, and the nature of the infiltrate becomes primarily mononuclear cells. Mast cell granules (MCG) purified, solubilized, and injected into rat skin have been shown to generate late-phase responses, indistinguishable from the responses elicited by mast cell degranulation. Amino acid analysis of the active inflammatory-provoking fraction was obtained after sequential purification of solubilized MCG (ultrafiltration, Sephadex G-25, anion and cation-exchange chromatography) and indicated the presence of a peptide of similar to 1400 m.w. containing 12 amino acids. Thus, the rat MCG matrix contains a preformed, previously uncharacterized 1400 m.w. factor that may be capable of inducing late-phase allergic responses in rat skin. JF - Journal of Immunology AU - Kaliner, M AU - Oertel, H L AD - Int. Health, NIAID, NCI, Bldg. 10, Rm. 11N-250, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 1398 EP - 1402 VL - 127 IS - 4 SN - 0022-1767, 0022-1767 KW - anaphylaxis KW - characterization KW - inflammation KW - mast cells KW - proteins KW - purification KW - rats KW - role KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - F 06735:Mediators KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15442687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=The+Biologic+Activity+of+Mast+Cell+Granules.+III.+Purification+of+Inflammatory+Factors+of+Anaphylaxis+%28IF-A%29+Responsible+for+Causing+Late-Phase+Reactions.&rft.au=Kaliner%2C+M%3BOertel%2C+H+L&rft.aulast=Kaliner&rft.aufirst=M&rft.date=1981-01-01&rft.volume=127&rft.issue=4&rft.spage=1398&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - inflammation; purification; anaphylaxis; mast cells; proteins ER - TY - JOUR T1 - Drug Uptake by Lung Slices From Paraquat-Pretreated Rats. AN - 15434861; 243328 AB - Lung slices from male Sprague-Dawley rats pretreated with paraquat (PQ) (100 mu moles multiplied by kg super(-1),i.v.) 16 h before sacrifice, accummulated less PQ in vitro than lung slices from saline-treated controls. Neither lung slices from PQ-pretreated nor saline control animals released (effluxed) PQ accumulated in vitro. The accumulation and efflux of imipramine and 5-hydroxytryptamine by lung slices was unaffected by prior in vivo administration of PQ. JF - Experientia. Basel AU - Drew, R AU - Siddik, Z S AD - Lab. Toxicol., N.C.I., N.I.H., Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 1093 EP - 1095 VL - 37 IS - 10 SN - 0014-4754, 0014-4754 KW - effects on KW - uptake KW - paraquat KW - rats KW - drugs KW - lung KW - Biochemistry Abstracts 1: Biological Membranes (till 1993); Toxicology Abstracts KW - X 24136:Environmental impact UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15434861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experientia.+Basel&rft.atitle=Drug+Uptake+by+Lung+Slices+From+Paraquat-Pretreated+Rats.&rft.au=Drew%2C+R%3BSiddik%2C+Z+S&rft.aulast=Drew&rft.aufirst=R&rft.date=1981-01-01&rft.volume=37&rft.issue=10&rft.spage=1093&rft.isbn=&rft.btitle=&rft.title=Experientia.+Basel&rft.issn=00144754&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - drugs; lung ER - TY - JOUR T1 - The Atomic Bomb Survivors and the Problem of Low-Dose Radiation Effects. AN - 15428100; 243594 JF - American Journal of Epidemiology AU - Beebe, G W AD - Clin. Epidemiol. Branch, NCI-NIH, Rm 5A21 Landow Bldg., Beth, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 761 EP - 783 VL - 114 IS - 6 SN - 0002-9262, 0002-9262 KW - effects on KW - Toxicology Abstracts KW - radiation KW - atomic bombs KW - man KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15428100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=The+Atomic+Bomb+Survivors+and+the+Problem+of+Low-Dose+Radiation+Effects.&rft.au=Beebe%2C+G+W&rft.aulast=Beebe&rft.aufirst=G&rft.date=1981-01-01&rft.volume=114&rft.issue=6&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - atomic bombs; radiation; man ER - TY - JOUR T1 - Mechanism of Action of Choleragen and E. coli Heat-Labile Enterotoxin: Activation of Adenylate Cyclase by ADP-Ribosylation. AN - 15424398; 239918 AB - Choleragen exerts its effects on cells through the activation of adenylate cyclase. The initial event appears to be the binding of the B subunit of the toxin to ganglioside G sub(M1) on the cell surface, following which there is a delay prior to activation of adenylate cyclase. Patching and capping of the toxin on the cell surface, perhaps involved in the internalization of the enzymatically active subunit, may be occuring during this time. The activation of adenylate cyclase, which is catalyzed by the A sub(1) peptide of choleragen, does not require the B subunit or ganglioside G sub(M1). E. coli heat-labile enterotoxin (LT) is very similar to choleragen in structure and function. It consists of two types of subunits, A and B, with sizes comparable to those of the A and B subunits of choleragen. Binding of LT to the cell surface is enhanced by prior incorporation of G sub(M1) but not other gangliosides. JF - Molecular and Cellular Biochemistry AU - Moss, J AU - Vaughan, M AD - Lab. Cell. Metabol., NHLBI, NIH, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 75 EP - 90 VL - 37 IS - 2 SN - 0300-8177, 0300-8177 KW - effects on KW - adenylate cyclase KW - Escherichia coli KW - Vibrio cholerae KW - enterotoxins KW - receptors KW - toxins KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 1: Biological Membranes (till 1993) KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15424398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biochemistry&rft.atitle=Mechanism+of+Action+of+Choleragen+and+E.+coli+Heat-Labile+Enterotoxin%3A+Activation+of+Adenylate+Cyclase+by+ADP-Ribosylation.&rft.au=Moss%2C+J%3BVaughan%2C+M&rft.aulast=Moss&rft.aufirst=J&rft.date=1981-01-01&rft.volume=37&rft.issue=2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biochemistry&rft.issn=03008177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Vibrio cholerae; Escherichia coli; toxins; receptors; enterotoxins ER - TY - JOUR T1 - In Vitro Activation of the Enzymic Activity of Hepatic Lipase by ApoA-II. AN - 15409494; 232178 AB - In initial studies it has been observed that human plasma activates HL enzymic activity. It was the purpose of this study to further define the component within plasma which is responsible for this activation. The results of these investigations indicate that under the conditions studied, apoA-II, a protein constituent of human HDL activates HL. JF - FEBS Letters AU - Jahn, CE AU - Osborne, JC Jr AU - Schaefer, E J AU - Brewer, HB Jr AD - Mol. Disease Branch, NHLBI, NIH, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 366 EP - 368 VL - 131 IS - 2 SN - 0014-5793, 0014-5793 KW - activation KW - apoprotein A-II KW - man KW - plasma KW - triacylglycerol lipase KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15409494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=In+Vitro+Activation+of+the+Enzymic+Activity+of+Hepatic+Lipase+by+ApoA-II.&rft.au=Jahn%2C+CE%3BOsborne%2C+JC+Jr%3BSchaefer%2C+E+J%3BBrewer%2C+HB+Jr&rft.aulast=Jahn&rft.aufirst=CE&rft.date=1981-01-01&rft.volume=131&rft.issue=2&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Purification and Properties of the Escherichia coli Protein Factor Required for lambda Integrative Recombination. AN - 15404570; 216504 AB - A purified preparation of the Escherichia coli integration host factor (IHF) displays two polypeptides of apparent molecular weight 11,000 and 9,500 when analyzed by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. Under nondenaturing conditions, IHF appears to exist as a 1:1 complex of these two polypeptides. Integrative recombination takes place in vitro when purified IHF and purified Int, a product of a bacteriophage lambda gene, are the only proteins added to reaction mixtures. No recombination is detected in the absence of either protein. The characteristics of the recombination reaction carried out by these two purified proteins are described. Purified IHF binds to DNA; in the presence of Int, a ternary complex is formed at one of the specific recombination sites. IHF has no detectable endonuclease or topoisomerase activity. Several possibilities for the role of IHF in recombination are considered. JF - Journal of Biological Chemistry AU - Nash, HA AU - Robertson, CA AD - Lab. Neurochem., NIMH, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 9246 EP - 9253 VL - 256 IS - 17 SN - 0021-9258, 0021-9258 KW - Escherichia coli KW - characterization KW - integration KW - phage lambda KW - proteins KW - purification KW - recombination KW - role KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - G 07310:PHAGES-GREEK LETTER NAMES KW - J 02750:Phage-host interactions KW - V 22070:Phage-host interactions including lysogeny & transduction KW - J 02727:Amino acids, peptides and proteins KW - N 14940:Nucleic acid-binding proteins KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15404570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Purification+and+Properties+of+the+Escherichia+coli+Protein+Factor+Required+for+lambda+Integrative+Recombination.&rft.au=Nash%2C+HA%3BRobertson%2C+CA&rft.aulast=Nash&rft.aufirst=HA&rft.date=1981-01-01&rft.volume=256&rft.issue=17&rft.spage=9246&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - integration; recombination; purification; proteins ER - TY - JOUR T1 - Carcinogenicity of Picloram. AN - 15403262; 227419 AB - Examination of histological sections showed that picloram is hgihly carcinogenic in rats and mice. Neoplasms at all sites, including malignant neoplasms, were increased in male and female rats given both low and high doses of picloram in the National Cancer Institute rat study.The malignant neoplasms were both carcinomas and sarcomas. Neoplasms of the endocrine organs, particularly carcinomas, were increased in male and female rats given picloram. These carcinomas were observed in the adrenal, thyroid, and pituitary glands. Neoplasms were also increased in the liver of male and female rats and in the reproductive organs of female rats given picloram. Male and female mice exposed to picloram developed neoplasms of the spleen in the National Cancer Institute mouse study. There were also toxic changes in rats and mice. Male rats had chronic renal disease, parthyroid hyperplasia, and polyarteritis. There was atrophy of the testes in both male rats and mice given picloram. JF - Journal of Toxicology and Environmental Health AU - Reuber, MD AD - Exp. Pathol. Labratory, NCI Frederick Cancer Res. CTR. Frederick, MD 21701, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 207 EP - 222 VL - 7 IS - 2 SN - 0093-4108, 0093-4108 KW - picloram KW - rats KW - mice KW - Toxicology Abstracts KW - carcinogenesis KW - pesticides KW - X 24134:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15403262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health&rft.atitle=Carcinogenicity+of+Picloram.&rft.au=Reuber%2C+MD&rft.aulast=Reuber&rft.aufirst=MD&rft.date=1981-01-01&rft.volume=7&rft.issue=2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health&rft.issn=00934108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenesis; pesticides ER - TY - JOUR T1 - Carcinogenicity Tests of Certain Environmental and Industrial Chemicals. AN - 15400816; 227103 AB - Fourteen chemicals of varied uses were tested for carcinogenicity by oral administration in male and female Charles River CD rats. Under the conditions of the tests, propane sultone, propylene imine, and ethylenethiourea, in addition to the positive control N-2-fluorenylacetamide, were carcinogenic. Avadex, bis(2-chloroethyl) ether, the potassium salt of bis(2-hydroxyethyl)dithiocarbamic acid, ethylene carbonate, and semicarbazide hydrochloride were not carcinogenic under the test conditions. Dithiooxamide, glycerol alpha -monochlorohydrin, and thiosemicarbazide gave somewhat ambiguous results, though administered at high enough dose levels to be toxic. An inadequate number of animals survived treatments with sodium azide, sodium bisulfide, and vinylene carbonate, or the animals may not have received sufficiently high doses of the test chemicals to provide maximum test sensitivity. However, there were no indications that these three chemicals were carcinogenic under the test conditions. JF - Journal of the National Cancer Institute AU - Weisburger, E K AU - Ulland, B M AU - Nam, J M AU - Gart, J J AU - Weisburger, J H AD - Lab. Carcinogen Matabolism, Div. Cancer Cause Prevention, NCI, NIH, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 75 EP - 88 VL - 67 IS - 1 SN - 0027-8874, 0027-8874 KW - rats KW - Toxicology Abstracts KW - chemicals KW - carcinogenicity testing KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15400816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Carcinogenicity+Tests+of+Certain+Environmental+and+Industrial+Chemicals.&rft.au=Weisburger%2C+E+K%3BUlland%2C+B+M%3BNam%2C+J+M%3BGart%2C+J+J%3BWeisburger%2C+J+H&rft.aulast=Weisburger&rft.aufirst=E&rft.date=1981-01-01&rft.volume=67&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenicity testing; chemicals ER - TY - JOUR T1 - Nitrosamine-Induced Transplantable Pancreatic Ductal Adenocarcinoma in Inbred Syrian Hamsters. AN - 15398499; 213748 AB - A pancreatic ductal carcinoma, designated CBP, was established as a transplantable tumor line in the CB/SsLak inbred strain of Syrian golden hamsters. The tumor, a primary one induced by chronic administration of the nitrosamine N-nitro-bis(2-hydroxypropyl)amine, is a well-differentiated adenocarcinoma that can be propagated by transplantation in syngeneic hamsters. It grows poorly in other hamster strains. The CBP tumor develops in a predictable quantitative manner and metastasizes to regional lymph nodes. Excision of primary transplanted tumor nodules leads to immunity against subsequent secondary tumor challenges. The CBP tumor appears to be a suitable model for biologic and immunologic studies of pancreatic carcinoma in the Syrian hamster. JF - Journal of the National Cancer Institute AU - Sindelar, W F AU - Kurman, C C AD - NCI, NIH, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 1093 EP - 1100 VL - 67 IS - 5 SN - 0027-8874, 0027-8874 KW - induction KW - N-nitro-bis(2-hydroxypropyl)amine KW - hamsters KW - Toxicology Abstracts KW - pancreas KW - carcinoma KW - X 24200:Nitrosamines & related compounds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15398499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Nitrosamine-Induced+Transplantable+Pancreatic+Ductal+Adenocarcinoma+in+Inbred+Syrian+Hamsters.&rft.au=Sindelar%2C+W+F%3BKurman%2C+C+C&rft.aulast=Sindelar&rft.aufirst=W&rft.date=1981-01-01&rft.volume=67&rft.issue=5&rft.spage=1093&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - pancreas; carcinoma ER - TY - JOUR T1 - Calmodulin-Activated Cyclic Nucleotide Phosphodiesterase From Brain. Changes in Molecular Size Assessed by Gel Filtration and Electrophoresis. AN - 15396923; 216843 AB - The calmodulin-activated cyclic nucleotide phosphodiesterase from bovine brain cortex has been extensively purified by two methods, both of which yield preparations containing a single major polypeptide of 58,000 daltons as judged by gel electrophoresis under denaturing conditions. The preparations have similar specific activities in the presence of calmodulin (plus Ca super(2+)) but differ in the degree to which they are activated by this effector. After storage for several days at 4 degree C, the enzyme had the chromatographic behavior expected for a protein of 120,000-14,000 daltons and was stimulated to a greater degree by Ca super(2+) plus calmodulin. Thus, phosphodiesterase exists as interconvertible monomeric and oligomeric species and that these are activated to different degrees by calmodulin. JF - Journal of Biological Chemistry AU - Kincaid, R L AU - Manganiello, V C AU - Vaughan, M AD - Lab. Cell. Metabolism, NHLBI, NIH, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 11345 EP - 11350 VL - 256 IS - 21 SN - 0021-9258, 0021-9258 KW - 3':5'-cyclic-nucleotide phosphodiesterase KW - aggregation KW - brain KW - cattle KW - purification KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15396923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Calmodulin-Activated+Cyclic+Nucleotide+Phosphodiesterase+From+Brain.+Changes+in+Molecular+Size+Assessed+by+Gel+Filtration+and+Electrophoresis.&rft.au=Kincaid%2C+R+L%3BManganiello%2C+V+C%3BVaughan%2C+M&rft.aulast=Kincaid&rft.aufirst=R&rft.date=1981-01-01&rft.volume=256&rft.issue=21&rft.spage=11345&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Conjugated Estrogens and Breast Cancer Risk in Women. AN - 15396734; 215620 AB - The relationship between conjugated estrogen(s) (CE) and breast cancer was investigated by the examination of the records of 345 women with newly diagnosed breast cancer and 611 healthy controls belonging to a prepaid health plan. Use of CE was associated with a 40% elevation in risk (relative risk (RR)=1.4; 95% confidence interval=1.0-2.0). The RR was 1.3 for menopausal women with intact ovaries and 1.5 for those with ovaries removed. There was statistically significant evidence of a dose-response relationship with the three measures of dose evaluated. RR's rose to about twofold for women with 10 or more CE prescriptions noted in their charts, for those with 5 years or more between their first and last prescription, and for those with a usual daily dose 1.25 mg or more. The RR associated with having over used CE and with long-term use was highest among those women with a family history of breast cancer. These data support the hypothesis that long-term use of CE is associated with increased breast cancer risk. JF - J. NAT. CANCER INST. AU - Hoover, R AU - Glass, A AU - Finkle, W D AU - Azevedo, D AU - Milne, K AD - NCI, NIH, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 815 EP - 820 VL - 67 IS - 4 SN - 0027-8874, 0027-8874 KW - relationship KW - estrogens KW - Toxicology Abstracts KW - breast KW - man KW - carcinoma KW - X 24112:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15396734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+NAT.+CANCER+INST.&rft.atitle=Conjugated+Estrogens+and+Breast+Cancer+Risk+in+Women.&rft.au=Hoover%2C+R%3BGlass%2C+A%3BFinkle%2C+W+D%3BAzevedo%2C+D%3BMilne%2C+K&rft.aulast=Hoover&rft.aufirst=R&rft.date=1981-01-01&rft.volume=67&rft.issue=4&rft.spage=815&rft.isbn=&rft.btitle=&rft.title=J.+NAT.+CANCER+INST.&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - breast; carcinoma; man ER - TY - JOUR T1 - Septicemic Complications of the Cutaneous T-Cell Lymphomas. AN - 15395207; 216856 AB - The records of 60 consecutive patients with cutaneous T-cell lymphomas were reviewed to determine the incidence, etiology, predisposing factors, therapy, complications and outcome of septicemia. Fourteen patients had 26 septicemias: due to gram-positive cocci in 21 and to gram-negative bacilli in five. The presence of stage IV lymphomatous disease, generalized erythroderma, palpable lymph nodes, and histologic involvement of lymph nodes and peripheral blood identified a subset of patients at high risk for sepsis. Sepsis was correlated with locally infected sites in 77 percent of episodes. Single antimicrobial therapy was successful in all septicemias due to gram-positive cocci but was accompanied by five secondary gram-negative bacillary superinfections (80 percent fatal). The subsequent mortality in all patients who survived infection (50 percent) indicated their poor over-all prognosis. JF - American Journal of Medicine AU - Fossieck, B E AU - Posner, LE AU - Eddy, J L AU - Bunn, P A AD - NCI/VA MOB, Veterans Admin. Med. Ctr., 50 Irving St., N.W., Washington, DC 20422, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 210 EP - 216 VL - 71 IS - 2 SN - 0002-9343, 0002-9343 KW - association KW - Microbiology Abstracts B: Bacteriology KW - lymphocytes T KW - bacteria KW - septicemia KW - lymphoma KW - man KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15395207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Medicine&rft.atitle=Septicemic+Complications+of+the+Cutaneous+T-Cell+Lymphomas.&rft.au=Fossieck%2C+B+E%3BPosner%2C+LE%3BEddy%2C+J+L%3BBunn%2C+P+A&rft.aulast=Fossieck&rft.aufirst=B&rft.date=1981-01-01&rft.volume=71&rft.issue=2&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - lymphocytes T; lymphoma; septicemia; bacteria; man ER - TY - JOUR T1 - Dehydro-Enkephalins: Receptor Binding Activity of Unsaturated Analogs of Leu super(5)-Enkephalin. AN - 15394389; 216594 AB - The authors have synthesized a series of unsaturated enkephalin analogs, dehydro-enkephalins ( Delta EK), which contain Delta Ala super(2 or 3), Delta Phe super(4) or Delta Leu super(5) residues. Attempts to prepare Delta Tyr super(1)-enkephalins have failed because of the hydrolytic instability of an N-terminal Delta Tyr residue. This paper discusses the binding affinity and selectivity of these Delta EKs for 2 types of opiate receptors, and shows that incorporation of a dehydroamino acid residue is an effective way to obtain enkephalin analogs with full receptor activity which are resistant to enzymic hydrolysis without changing the selectivity. JF - FEBS Letters AU - Shimohigashi, Y AU - Costa, T AU - Stammer, CH AD - NIH, NICHD, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 269 EP - 271 VL - 133 IS - 2 SN - 0014-5793, 0014-5793 KW - analogs KW - biding KW - enkephalin KW - opiates KW - receptors KW - structure-activity relationships KW - synthesis KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 1: Biological Membranes (till 1993) KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15394389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Dehydro-Enkephalins%3A+Receptor+Binding+Activity+of+Unsaturated+Analogs+of+Leu+super%285%29-Enkephalin.&rft.au=Shimohigashi%2C+Y%3BCosta%2C+T%3BStammer%2C+CH&rft.aulast=Shimohigashi&rft.aufirst=Y&rft.date=1981-01-01&rft.volume=133&rft.issue=2&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Calmodulin-Activated Cyclic Nucleotide Phosphodiesterase From Brain. Relationship of Subunit Structure to Activity Assessed by Radiation Inactivation. AN - 15393107; 216857 AB - The apparent target sizes of the basal and calmodulin-dependent activities of calmodulin-activated phosphodiesterase from bovine brain were estimated using target theory analysis of data from radiation inactivation experiments. Low doses of radiation caused a 10 to 15% increase in basal activity, which, with further irradiation, decayed with an apparent target size of similar to 60,000 daltons. Calmodulin-dependent activity decayed with an apparent target size of similar to 105,000 daltons. The percentage stimulation of enzyme activity by calmodulin decreased markedly as a function of radiation dosage. These observations are consistent with results predicted by computer-assisted modeling based on the assumptions that: 1) the calmodulin-activated phosphodiesterase exists as a mixture of monomers which are fully active in the absence of calmodulin and dimers which are inactive in the absence of calmodulin; 2) in the presence of calmodulin, a dimer exhibits activity equal to that of two monomers; 3) on radiation destruction of a dimer, an active monomer is generated. JF - Journal of Biological Chemistry AU - Kincaid, R L AU - Kempner, E AU - Manganiello, V C AU - Osborne, JC Jr AU - Vaughan, M AD - Lab. Cellular Metab., NHLBI, NIH, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 11351 EP - 11355 VL - 256 IS - 21 SN - 0021-9258, 0021-9258 KW - 3':5'-cyclic-nucleotide phosphodiesterase KW - activity KW - aggregation KW - brain KW - cattle KW - relationship KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15393107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Calmodulin-Activated+Cyclic+Nucleotide+Phosphodiesterase+From+Brain.+Relationship+of+Subunit+Structure+to+Activity+Assessed+by+Radiation+Inactivation.&rft.au=Kincaid%2C+R+L%3BKempner%2C+E%3BManganiello%2C+V+C%3BOsborne%2C+JC+Jr%3BVaughan%2C+M&rft.aulast=Kincaid&rft.aufirst=R&rft.date=1981-01-01&rft.volume=256&rft.issue=21&rft.spage=11351&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Complexes Formed Between the Restriction Endonuclease Eco K and Heteroduplex DNA. AN - 15390179; 216634 AB - The complexes between the Escherichia coli K restriction endonuclease and heteroduplex DNA (one strand methylated and one unmethylated) have been characterized and shown to have different properties from those formed with unmodified DNA. The nature of the heteroduplex complex appears to commit the enzyme to its methylase mode. JF - Journal of Molecular Biology AU - Yuan, R AU - Burckhardt, J AU - Weisemann, J AU - Hamilton, D L AD - Cancer Biol. Prog., NCI Frederick Cancer Res. Cent., P.O. Box B, Frederick, MD 21701, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 425 EP - 440 VL - 153 IS - 2 SN - 0022-2836, 0022-2836 KW - DNA KW - Escherichia coli KW - endodeoxyribonuclease EcoK KW - heteroduplex KW - interaction KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - J 02725:DNA KW - G 07320:Bacterial genetics KW - N 14712:DNases KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15390179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Complexes+Formed+Between+the+Restriction+Endonuclease+Eco+K+and+Heteroduplex+DNA.&rft.au=Yuan%2C+R%3BBurckhardt%2C+J%3BWeisemann%2C+J%3BHamilton%2C+D+L&rft.aulast=Yuan&rft.aufirst=R&rft.date=1981-01-01&rft.volume=153&rft.issue=2&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - DNA; heteroduplex ER - TY - JOUR T1 - Cyclic Urea Nucleosides. Cytidine Deaminase Activity as a Function of Aglycon Ring Size. AN - 15385269; 200807 AB - Five beta -D-ribofuranosyl cyclic urea nucleosides (14-18), ranging in ring size from five to eight membered, were synthesized and evaluated as cytidine deaminase (CDA) inhibitors. The precursor protected nucleosides (9-13) were prepared by a condensation procedure utilizing persilylated ureas with a halo sugar under the specific catalytic activity of a HgO/HgBr sub(2) mixture which provided exclusively the beta -anomers. Catalytic hydrogenation of known 1-(2,3,5-tri-O-benzoyl- beta -ribofuranosyl)-1,2-dihydropyrimidin-2-one (19) afforded nucleoside 10 identical with that obtained by the mercury-catalyzed condensation procedure. CDA activity varies significantly with the ring size of the urea aglycon and reaches its maximum level for the seven-membered analogues 16 and 17. The unexpected high potency of nucleoside 17 (K sub(i) = 2.5 x 10 super(-8) M, human liver enzyme) is reported. This compound represents the most potent inhibitor of human liver CDA yet disovered. JF - Journal of Medicinal Chemistry AU - Marquez, V E AU - Liu, P AU - Driscoll, J S AU - Fuller, R W AD - Drug Design Chem. Sect., Lab. Med. Chem. Biol., NCI, NIH, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 662 EP - 666 VL - 24 IS - 6 SN - 0022-2623, 0022-2623 KW - beta -D-ribofuranosyl cylic urea nucleosides KW - cytidine deaminase KW - inhibition KW - liver KW - man KW - synthesis KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - N 14140:Chemical synthesis & properties KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15385269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Cyclic+Urea+Nucleosides.+Cytidine+Deaminase+Activity+as+a+Function+of+Aglycon+Ring+Size.&rft.au=Marquez%2C+V+E%3BLiu%2C+P%3BDriscoll%2C+J+S%3BFuller%2C+R+W&rft.aulast=Marquez&rft.aufirst=V&rft.date=1981-01-01&rft.volume=24&rft.issue=6&rft.spage=662&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - liver; synthesis; man ER - TY - JOUR T1 - Carcinogenicity of Dichlorvos. AN - 15362835; 185418 AB - There have been three chronic rat studies and one chronic mouse study, as well s subchronic dog and swine studies, on the toxicity and carcinogenicity ofdichlorvos. Dichlorvos is carcinogenic for rats and mice, and toxic for dogs and toxic for dogs and swine. There was an increase in benign and malignant neoplasms at all sites in male rats ingesting dichlorvos. Rats also developed fatty change and cholestasis of the liver, chronic interstitial nephritis, periarteritis, and atrophy of the testes. Dichlorvos is carcinogenic for the liver, esophagus , and forestomach of male mice, and for the bone of female mice. Male mice also developed atrophy of the testes. Hepatic changes, which were dose related, were observed in dogs and in swine ingestingdichlorvos. Chronic renal disease was also seen in dogs. Dose-related reductions in cholinesterase activity occurred in rats, dogs, and swine treated with dichlorvos. JF - Clinical Toxicology AU - Reuber, MD AD - NCI Frederick Cancer Res. Ctr. Frederick, MD 21701, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 47 EP - 84 VL - 18 IS - 1 KW - carcinogenicity KW - pesticides (organophosphorus) KW - dichlorvos KW - rats KW - mice KW - dogs KW - cattle KW - Toxicology Abstracts KW - reviews KW - X 24132:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15362835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Toxicology&rft.atitle=Carcinogenicity+of+Dichlorvos.&rft.au=Reuber%2C+MD&rft.aulast=Reuber&rft.aufirst=MD&rft.date=1981-01-01&rft.volume=18&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Clinical+Toxicology&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - reviews ER - TY - JOUR T1 - Acute Amphetamine Response Predicts Antidepressant and Antipsychotic Responses to Lithium Carbonate in Schizophrenic Patients. AN - 15359420; 184703 AB - Acute behavioral changes following 20 mg i.v. d-amphetamine predicted the small antipsychotic and antidepressant effects of the third week of lithium treatment in schizophrenic patients. Multivariate regression models accounted for 95% of the variance predicting the antipsychotic effects and for 89% of the variance predicting the antidepressant effects in postpsychotic depressed patients. The greater the increases in the d-amphetamine-induced changes in the thought disorder cluster of the Brief Psychiatric Rating Scale, the greater the antipsychotic effects of lithium. The data suggest that the modest behavioral changes observed with lithium in schizophrenia are most likely drug-induced. JF - PSYCHIATR. RES. AU - Van Kammen, DP AU - Docherty, J P AU - Marder AU - Bunney, WE Jr AD - NIMH, Bldg. 10, Rm 4N-214, 9000 Rockville Pike, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 313 EP - 325 VL - 4 IS - 3 KW - behavior KW - lithium KW - drugs, effects on KW - Toxicology Abstracts KW - schizophrenia KW - man KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15359420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PSYCHIATR.+RES.&rft.atitle=Acute+Amphetamine+Response+Predicts+Antidepressant+and+Antipsychotic+Responses+to+Lithium+Carbonate+in+Schizophrenic+Patients.&rft.au=Van+Kammen%2C+DP%3BDocherty%2C+J+P%3BMarder%3BBunney%2C+WE+Jr&rft.aulast=Van+Kammen&rft.aufirst=DP&rft.date=1981-01-01&rft.volume=4&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=PSYCHIATR.+RES.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - schizophrenia; man ER - TY - JOUR T1 - Effect of Indomethacin on the Blood Pressure and Plasma Catecholamine Responses to Acute Endotoxaemia. AN - 15356483; 185093 AB - Injection of E. coli endotoxin (7 mg kg super(-1) i.v.) to pentobarbitone anaesthetized cats resulted in prolonged decrease of systemic blood pressure and increases in plasma concentrations of adrenaline, noradrenaline and 6-ketoprostaglandin (PG) F sub(1 alpha ). Indomethacin pretreatment (10 mg kg super(-1) i.v.) attenuated the decrease in blood pressure following endotoxin injection. Plasma adrenaline, noradrenaline and 6-keto-PG F sub(1 alpha ) were significantly lower in the indomethacin-treated cats. These data indicate that the superior haemodynamic status of the indomethacin pretreated animals exposed to endotoxic shock is not the result of potentiation of the peripheral sympathetic response. JF - Journal of Pharmacy and Pharmacology AU - Feuerstein, G AU - Dimicco, JA AU - Ramu, A AU - Kopin, I J AD - Lab. Clin. Sci., NIMH, Bldg. 10, Room 2D53, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 576 EP - 579 VL - 33 IS - 9 SN - 0022-3573, 0022-3573 KW - effects on KW - endotoxin KW - indomethacin KW - cats KW - Toxicology Abstracts KW - Escherichia coli KW - endotoxin shock KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15356483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmacy+and+Pharmacology&rft.atitle=Effect+of+Indomethacin+on+the+Blood+Pressure+and+Plasma+Catecholamine+Responses+to+Acute+Endotoxaemia.&rft.au=Feuerstein%2C+G%3BDimicco%2C+JA%3BRamu%2C+A%3BKopin%2C+I+J&rft.aulast=Feuerstein&rft.aufirst=G&rft.date=1981-01-01&rft.volume=33&rft.issue=9&rft.spage=576&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmacy+and+Pharmacology&rft.issn=00223573&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Escherichia coli; endotoxin shock ER - TY - JOUR T1 - Cyclophosphamide and Dimethylsulfoxide in the Treatment of Squamous Carcinoma of the Lung Therapeutic Efficacy, Toxicity, and Pharmacokinetics. AN - 15343230; 170291 AB - 14 patients were treated with 51 of a 5% or 6% dimethylsulfoxide (DMSO) solution PO over 3 days and 1,500 mg cyclophosphamide (CYC)/m super(2) 1V as a 60-min infusion on the third day of treatment. Serial blood CSF, and urine samples were collected to assess the pharmacokinetics of CYC. No antitumor responses were observed. Toxicity was mainly hematologic and similar to that of CYC alone. There was one death from infection during granulocytopenia. Nonhematologic toxicity was moderate to severe and included nausea (14 patients) and vomiting (five patients). JF - Cancer Chemotherapy and Pharmacology AU - Fuks, J Z AU - Egorin, MJ AU - Aisner, J AU - Ostrow, S S AU - Klein, ME AU - Bachur, N R AU - Colvin, M AU - Wiernik, PH AD - Baltimore Cancer Res. Program, DCT, NCI, 22 S. Greene St., Baltimore, MD 21201, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 117 EP - 120 VL - 6 IS - 2 KW - effects on KW - dimethyl sulfoxide KW - cyclophosphamide KW - Toxicology Abstracts KW - antitumor agents KW - man KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15343230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Chemotherapy+and+Pharmacology&rft.atitle=Cyclophosphamide+and+Dimethylsulfoxide+in+the+Treatment+of+Squamous+Carcinoma+of+the+Lung+Therapeutic+Efficacy%2C+Toxicity%2C+and+Pharmacokinetics.&rft.au=Fuks%2C+J+Z%3BEgorin%2C+MJ%3BAisner%2C+J%3BOstrow%2C+S+S%3BKlein%2C+ME%3BBachur%2C+N+R%3BColvin%2C+M%3BWiernik%2C+PH&rft.aulast=Fuks&rft.aufirst=J&rft.date=1981-01-01&rft.volume=6&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Cancer+Chemotherapy+and+Pharmacology&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - man; antitumor agents ER - TY - JOUR T1 - Effect of Sangivamycin and Xylosyladenine on the Synthesis and Methylation of Polysomal Ribonucleic Acid Ehrlich Ascites Cells In Vitro. AN - 15338125; 169703 AB - The synthesis of non-polyriboadenylic acid (non-poly (A)-) and poly(A)-containing RNA was inhibited 50 per cent at concentrations of 7 x 10 super(-6) M and 3 x 10 super(-6) M xylosyladenine, respectively, when adenosine deaminase was inhibited with 2'-deoxycoformycin. Sangivamycin inhibited the synthesis of non-poly(A)- and poly(A)RNA by 50 per cent at concentrations of 5 x 10 super(-5) M and 2 x 10 super(-5) M respectively. Electrophoretic separation of non-poly(A) RNA into rRNA and tRNA indicated that the inhibitory effects of both drugs were more pronounced on 28S than on 18S rRNA, and that xylosyladenine but not sangivamycin inhibited the synthesis of tRNA. Assessment of the effects of both analogs on the methylation of polysomal RNA revealed that xylosyladenine inhibited the methylation of non-poly(A)- and poly(A) RNA, while sangivamycin only weakly affected the latter species of RNA. These results indicate that sangivamycin is a more selective inhibitor of polysomal RNA in comparison to xylosyladenine under conditions where adenosine demainase is not a limiting factor. JF - Biochemical Pharmacology AU - Glazer, R I AU - Hartman, K D AU - Cohen, O J AD - Lab. Medicinal Chem. Biol., DTP, DCT, NCI, Building 37, RM 6D28, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 2697 EP - 2701 VL - 30 IS - 19 SN - 0006-2952, 0006-2952 KW - effects on KW - sangivamycin KW - xylosyladenine KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - polyribosomes KW - methylation KW - RNA biosynthesis KW - Ehrlich ascites tumor cells KW - X 24117:Biochemistry KW - N 14555:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15338125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Pharmacology&rft.atitle=Effect+of+Sangivamycin+and+Xylosyladenine+on+the+Synthesis+and+Methylation+of+Polysomal+Ribonucleic+Acid+Ehrlich+Ascites+Cells+In+Vitro.&rft.au=Glazer%2C+R+I%3BHartman%2C+K+D%3BCohen%2C+O+J&rft.aulast=Glazer&rft.aufirst=R&rft.date=1981-01-01&rft.volume=30&rft.issue=19&rft.spage=2697&rft.isbn=&rft.btitle=&rft.title=Biochemical+Pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Ehrlich ascites tumor cells; methylation; RNA biosynthesis; polyribosomes ER - TY - JOUR T1 - Alterations of Immune Response of DBA/2 Mice by Procarbazine Treatment. AN - 15332641; 156340 AB - Bacterial lipopolysaccharide (LPS) and sheep red blood cells (SRBC) were used as antigens to investigate the in vivo dose- and time-dependent effects of procarbazine k(PCZ) treatment on antibody responses of adult male DBA/2 mice. Procarbazine treatment had essentially no effect on the number of LPS antibody-producing cells in spleens of mice in the entire range of PCZ dose and time, while the circulating antibody to LPS in serum diminished in mice treated with 600 mg/kg dose. In contrast, PCZ treatment altered the plaque-forming cell (PFC) response of the mice to T-cell dependent antigen SRBC. Besides the antibody-producing cells in spleen, the antibody titer to SRBC in serum was also significantly diminished. This markedly reduced immune response, however, was released with the passage of time and was almost completely recovered by day 21 after the PCZ treatment of the mice. In addition, a very significant decrease in the number of cells per spleen was observed at 600 mg dose. It is suggested that PCZ exerts its immunosuppresive effects by essentially affecting T cells, both by decreasing the antibody synthesis as well as the number of cells. JF - Immunopharmacology AU - Baig, MA AU - Ansari, A A AD - Building 7, Rm. 703, NIEHS, PO Box 12233, Research Triangle Park, NC 27709, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 129 EP - 136 VL - 3 IS - 2 SN - 0162-3109, 0162-3109 KW - procarbazine KW - mice KW - Toxicology Abstracts; Immunology Abstracts KW - immunosuppression KW - lymphocytes T KW - F 06791:Experimental KW - X 24112:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15332641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunopharmacology&rft.atitle=Alterations+of+Immune+Response+of+DBA%2F2+Mice+by+Procarbazine+Treatment.&rft.au=Baig%2C+MA%3BAnsari%2C+A+A&rft.aulast=Baig&rft.aufirst=MA&rft.date=1981-01-01&rft.volume=3&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Immunopharmacology&rft.issn=01623109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - immunosuppression; lymphocytes T ER - TY - JOUR T1 - A Novel Role for Site-Specific Recombination in Maintenance of Bacterial Replicons. AN - 15322868; 137199 AB - If daughter copies of unit-copy replicons recombine with each other, a replicon dimer results that cannot be partitioned equally to daughter cells at cell division. The authors present evidence that dimer formation interferes with plasmid equipartition in the case of a miniplasmid derived from the unit-copy plasmid prophage of bacteriophage P1. Asymmetric partition occurs, leading to a relatively high rate of loss of the plasmid from the growing population. In contrast, the wild-type P1 plasmid is maintained very efficiently in host cells. This efficient maintenance is due to the presence of the lox P-cresite-specific recombination system present on the intact P1 plasmid. This system promotes rapid recombination between two loxP sites on dimer molecules, resolving them into monomeric substrates for proper partition. It is suggested that bacterial replicons that are maintained with great accuracy in recombination-proficient cells might also encode high-efficiency recombination systems. JF - Cell AU - Austin, S AU - Ziese, M AU - Sternberg, N AD - Cancer Biol. Program, NCI Frederick Cancer Res. Ctr., Frederick, MD 21701, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 729 EP - 736 VL - 25 IS - 3 SN - 0092-8674, 0092-8674 KW - maintenance KW - effects on KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - replicons KW - recombination KW - plasmids KW - dimers KW - J 02760:Plasmids KW - G 07200:P PLASMIDS KW - N 14660:Biological properties UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15322868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell&rft.atitle=A+Novel+Role+for+Site-Specific+Recombination+in+Maintenance+of+Bacterial+Replicons.&rft.au=Austin%2C+S%3BZiese%2C+M%3BSternberg%2C+N&rft.aulast=Austin&rft.aufirst=S&rft.date=1981-01-01&rft.volume=25&rft.issue=3&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Cell&rft.issn=00928674&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - plasmids; replicons; recombination; dimers ER - TY - JOUR T1 - Methadone Reduces Sexual Performance and Sexual Motivation in the Male Syrian Golden Hamster. AN - 15317267; 125267 AB - The purpose of the current study was to examine the effects of the opiate drug methadone and the opiate blocking drug naltrexone on the sexual behavior of male hamsters. Methadone, administered at dosages of 1, 2, 4, 8, and 16 mg/kg, was found to cause a dose related decline in measures of both sexual performance and sexual motivation, with measures of sexual performance being the more sensitive to the drug. The debiliting effect of methadone was judged to be highly selective for sexual behavior since, for example, at 16 mg/kg of methadone, sexual behavior was eliminated but ambulatory activity was unaffected. Pretreatment with naltrexone blocked the effects of methadone and posttreatment reversed the effects, thereby indicating that the methadone was inhibiting sexual behavior by acting on specific opiate receptors. The results demonstrate that the hamster is an excellent small animal model for use in studying the mechanisms of opiate induced sexual dysfunction and further support the hypothesis that the endogenous opiates may be involved in the regulation of sexual behavior. JF - Pharmacology Biochemistry and Behavior AU - Murphy, M R AD - Lab. Brain Evolution & Behavior, NIMH, Box 289, Poolesville, MD 20837, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 561 EP - 567 VL - 14 IS - 4 SN - 0091-3057, 0091-3057 KW - males KW - effects on KW - drug effects KW - methadone KW - hamsters KW - Toxicology Abstracts; Animal Behavior Abstracts KW - sexual behavior KW - motivation KW - Mesocricetus auratus KW - Y 25427:Mammals (excluding primates) KW - X 24113:Side effects KW - Y 25817:Mammals (excluding primates) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15317267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+Biochemistry+and+Behavior&rft.atitle=Methadone+Reduces+Sexual+Performance+and+Sexual+Motivation+in+the+Male+Syrian+Golden+Hamster.&rft.au=Murphy%2C+M+R&rft.aulast=Murphy&rft.aufirst=M&rft.date=1981-01-01&rft.volume=14&rft.issue=4&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Pharmacology+Biochemistry+and+Behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Mesocricetus auratus; motivation; sexual behavior ER - TY - JOUR T1 - A Clinical Trial of Pyrazofurin in Combination With 5-Azacytidine in Acute Adult Nonlymphocytic Leukemia. AN - 15315999; 121812 AB - Twenty adult patients with relapsed acute non-lymphocytic leukemia were given intravenously the combination of pyrazofurin (PF) on day 1 plus 5-azacytidine (AZA) in three divided doses for 5 days. Duration of response was short (41-94) days. The combination has significantly more nonhematologic toxicity than AZA alone and no therapeutic advantage over treatment with AZA alone. JF - Cancer Clinical Trials AU - Van Echo, DA AU - Chiuten, D F AU - Markus, S AU - Wiernik, PH AD - Clin. Oncol. Br., BCRP, DCT, NCI, Univ. Maryland Hosp., 22 South Greene St., Baltimore, MD 21201, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 129 EP - 133 VL - 4 IS - 2 KW - pyrazofurin KW - 5-azacytidine KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - acute toxicity KW - treatment KW - leukemia KW - man KW - N 14160:Biological properties KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15315999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Clinical+Trials&rft.atitle=A+Clinical+Trial+of+Pyrazofurin+in+Combination+With+5-Azacytidine+in+Acute+Adult+Nonlymphocytic+Leukemia.&rft.au=Van+Echo%2C+DA%3BChiuten%2C+D+F%3BMarkus%2C+S%3BWiernik%2C+PH&rft.aulast=Van+Echo&rft.aufirst=DA&rft.date=1981-01-01&rft.volume=4&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Cancer+Clinical+Trials&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - treatment; leukemia; acute toxicity; man ER - TY - JOUR T1 - Spin-Tranpping and ESR Studies of the Direct Photolysis of Aromatic Amino Acids, Dipeptides, Tripeptides and Polypeptides in Aqueous Solutions--I. Phenylalanine and Related Compounds. AN - 15315797; 136901 AB - The direct UV photolysis of L-Phe and peptides containing L-Phe in aqueous solutions has been investigated at room temperature. The short-lived free radicals formed during photolysis were spin-trapped by t-nitrosobutane and identified by electron spin resonance. During the photolysis of L-Phe the decarboxylation and the deamination radicals were spin-trapped. For N-formyl and N-acetyl-L-Phe the decarboxylation radicals were observed. For dipeptides containing Phe the decarboxylation radicals were observed and in some cases the deamination radicals from the N-terminal residue were found. For the tripeptides Gly-L-Phe-L-Ala and Gly-Gly-L-Phe, the C-terminal decarboxylation radical was spin trapped; for L-Phe-Gly-Gly only the deamination radical of the N-terminal residue could be detected. However, for Gly-L-Phe-Gly, five different radicals were identified. The results of the spin-trapping experiments of the 260 nm photolysis of RNase-S-peptide, containing 20 amino acid residues, was interpreted in terms of a chain scission between the alpha carbon of the Phe residue and the adjacent carbonyl group. JF - Photochemistry and Photobiology AU - Lion, Y AU - Kuwabara, M AU - Riesz, P AD - Lab. Pathophysiol., NCI, NIH, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 297 EP - 207 VL - 34 IS - 3 SN - 0031-8655, 0031-8655 KW - E.S.R. KW - amino acids KW - aromatic KW - photolysis KW - Microbiology Abstracts B: Bacteriology KW - J:20320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15315797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+Photobiology&rft.atitle=Spin-Tranpping+and+ESR+Studies+of+the+Direct+Photolysis+of+Aromatic+Amino+Acids%2C+Dipeptides%2C+Tripeptides+and+Polypeptides+in+Aqueous+Solutions--I.+Phenylalanine+and+Related+Compounds.&rft.au=Lion%2C+Y%3BKuwabara%2C+M%3BRiesz%2C+P&rft.aulast=Lion&rft.aufirst=Y&rft.date=1981-01-01&rft.volume=34&rft.issue=3&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+Photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 ER - TY - JOUR T1 - Chemically Induced Leukemia in Humans. AN - 15313725; 130376 AB - This paper reviews the association between exposure to chemicals, and acute leukemia. JF - Environmental Health Perspectives AU - Adamson, R H AU - Seiber, S M AD - Lab. Chem. Pharmaco., DTP, DCT, NCI, Nat. Cancer Inst., Bldg. 37, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 93 EP - 103 VL - 39 SN - 0091-6765, 0091-6765 KW - induction KW - Toxicology Abstracts KW - reviews KW - leukemia KW - chemicals KW - man KW - X 24250:Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15313725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Chemically+Induced+Leukemia+in+Humans.&rft.au=Adamson%2C+R+H%3BSeiber%2C+S+M&rft.aulast=Adamson&rft.aufirst=R&rft.date=1981-01-01&rft.volume=39&rft.issue=&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - chemicals; leukemia; man; reviews ER - TY - JOUR T1 - The Alcohol Facilitation Effect on Memory: A Dose-Response Study. AN - 15311917; 129968 AB - Sixteen normal male subjects participated in four sessions where they studied a set of pictures followed by either placebo, 0.025, 0.50, or 1.0 ml/kg alcohol. Later, when sober, recognition memory was tested. The 1.0 and 0.50 ml/kg doses significantly improved memory for pictures studied before drinking. Alcohol appears to enhance memory directly rather than indirectly via a reduction in interference. It is suggested that a particular phase of the rising blood alcohol curve (0.02-0.03 g/100 ml) facilitates trace consolidation. The facilitating and possibly excitatory effects of alcohol may be important for understanding the rewarding aspects of drinking. JF - Psychopharmacology AU - Parker, E S AU - Morihisa, J M AU - Wyatt, R J AU - Schwartz, B L AU - Weingartner, H AU - Stillman, R C AD - LPP, NIMH, Building 31, Rm. 4C-34, National Institutes of Health, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 88 EP - 92 VL - 74 IS - 1 SN - 0033-3158, 0033-3158 KW - effects on KW - alcohol KW - Toxicology Abstracts KW - man KW - memory KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15311917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=The+Alcohol+Facilitation+Effect+on+Memory%3A+A+Dose-Response+Study.&rft.au=Parker%2C+E+S%3BMorihisa%2C+J+M%3BWyatt%2C+R+J%3BSchwartz%2C+B+L%3BWeingartner%2C+H%3BStillman%2C+R+C&rft.aulast=Parker&rft.aufirst=E&rft.date=1981-01-01&rft.volume=74&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - memory; man ER - TY - JOUR T1 - Renal Toxicity Due to Reactive Metabolites Formed In Situ in the Kidney: Investigations With 4-Ipomeanol in the Mouse. AN - 15311072; 126035 AB - The in vitro metabolism and covalent binding of the furan derivative, 4-ipomeanol, was mediated by oxygen-requiring, NADPH-dependent, CO-inhibitable microsomal enzymes present in the livers, lungs and kidneys of adult male mice. These activities were inhibitable by piperonyl butoxide and they were markedly enhanced in hepatic microsomes from C57/6J mice, but not DBA/2J mice, pretreated with 3-methylcholanthrene. The i.p. administration of 4-ipomeanol to adult male mice resulted in the covalent binding of large amounts of its metabolite(s) in the lungs and kidneys. The material bound in the kidneys was located predominantly in the proximal renal cortical tubules. The covalent binding and toxicity of 4-ipomeanol to the renal tubules could be prevented by pretreatment of the animals with piperonyl butoxide. The hepatic covalent binding and toxicity of 4-ipomeanol were enhanced and the pulmonary and renal covalent binding and toxicity were decreased in C57BL/6J mice pretreated with 3-methylcholanthrene. JF - Journal of Pharmacology and Experimental Therapeutics AU - Boyd, M R AU - Dutcher, J S AD - Building 10, Rm. 6N-105, National Cancer Institute, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 640 EP - 646 VL - 216 IS - 3 SN - 0022-3565, 0022-3565 KW - binding KW - 4-ipomeanol KW - mice KW - Toxicology Abstracts KW - metabolic activation KW - renal failure KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15311072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmacology+and+Experimental+Therapeutics&rft.atitle=Renal+Toxicity+Due+to+Reactive+Metabolites+Formed+In+Situ+in+the+Kidney%3A+Investigations+With+4-Ipomeanol+in+the+Mouse.&rft.au=Boyd%2C+M+R%3BDutcher%2C+J+S&rft.aulast=Boyd&rft.aufirst=M&rft.date=1981-01-01&rft.volume=216&rft.issue=3&rft.spage=640&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmacology+and+Experimental+Therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - metabolic activation; renal failure ER - TY - JOUR T1 - Autonomic Effects of Dextroamphetamine in Normal Men: Implications for Hyperactivity and Schizophrenia. AN - 15289391; 111653 AB - This study tests the effects on autonomic nervous system (ANS) activity of two doses (0.25 mg/kg and 0.50 mg/kg) of dextroamphetamine in normal men. Skin conductance and heart rate were recorded during rest, tone presentation, and a reaction time task. Compared to placebo, dextroamphetamine increased both skin conductance and heart rate indices of arousal, slowed habituation, and reduced ANS responsivity selectively to more important versus less important stimuli. The last result differs from previous findings on hyperactive and normal boys. The pattern of ANS effects closely resembles findings on drug-free schizophrenics, suggesting that it may be a marker for biologic changes occurring in amphetamine psychosis and spontaneous psychotic episodes. JF - PSYCHIATR. RES. AU - Zahn, T P AU - Rapoport, J L AU - Thompson, CL AD - Bldg. 31, Rm. 4C39, NIMH, 9000 Rockville Pike, Bethesda, MD 20205, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 39 EP - 47 VL - 4 IS - 1 KW - effects on KW - dextroamphetamine KW - Toxicology Abstracts KW - autonomic nervous system KW - man KW - X 24111:Acute exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15289391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PSYCHIATR.+RES.&rft.atitle=Autonomic+Effects+of+Dextroamphetamine+in+Normal+Men%3A+Implications+for+Hyperactivity+and+Schizophrenia.&rft.au=Zahn%2C+T+P%3BRapoport%2C+J+L%3BThompson%2C+CL&rft.aulast=Zahn&rft.aufirst=T&rft.date=1981-01-01&rft.volume=4&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=PSYCHIATR.+RES.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - autonomic nervous system; man ER - TY - JOUR T1 - Physostigmine Induction of Depressive Symptomatology in Normal Human Subjects. AN - 15289340; 111647 AB - Nine normal volunteers, screened for the absence of a personal or family history of affective disorders and free of concurrent marijuana usage, received intravenous infusions of high dose physostigmine or saline in a randomized, double-blind, counterbalanced paradigm. Self-rating and observer ratings both demonstrated a statistically significant, physostigmine associated increase in depressive-type symptoms in the group as a whole, particularly pronounced in certain individuals. High dose physostigmine may represent a pharmacological model of depression in normal subjects, or alternatively may be diagnostic of vulnerability to affective disorder in certain subjects free of a previous history of affective disturbances. JF - PSYCHIATR. RES. AU - Risch, S C AU - Cohen, R M AU - Janowsky, D S AU - Kalin, N H AU - Sitaram, N AU - Gillin, J C AU - Murphy, D L AD - Clin. Neuropharmacol. Branch, NIMH, NIH Clin. Ctr., 10/3D41, Bethesda, MD 20205 USA Y1 - 1981 PY - 1981 DA - 1981 SP - 89 EP - 94 VL - 4 IS - 1 KW - effects on KW - physostigmine KW - Toxicology Abstracts KW - depression KW - man KW - X 24111:Acute exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15289340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PSYCHIATR.+RES.&rft.atitle=Physostigmine+Induction+of+Depressive+Symptomatology+in+Normal+Human+Subjects.&rft.au=Risch%2C+S+C%3BCohen%2C+R+M%3BJanowsky%2C+D+S%3BKalin%2C+N+H%3BSitaram%2C+N%3BGillin%2C+J+C%3BMurphy%2C+D+L&rft.aulast=Risch&rft.aufirst=S&rft.date=1981-01-01&rft.volume=4&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=PSYCHIATR.+RES.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - depression; man ER - TY - JOUR T1 - Effects of Chronic Ethanol Administration on O sub(2) Consumption in Whole Body and Perfused Liver of the Rat. AN - 15279328; 111868 AB - The effects of chronic ethanol consumption on thyroid hormone levels and the rates of whole animal and perfused liver oxygen consumption were determined to test the hypothesis that alcoholic liver damage is a result of thyroid mediated liver hypermetabolism. The data presented give no support to the concept that chronic ethanol ingestion results in hyperthyroidism or liver hypermetabolism and, consequently, the rationale for treatment of alcoholic hepatitis with the antithyroid drug, propylthiouracil, is incorrect. JF - ALCOHOL., CLIN. EXP. RES. AU - Schaffer, W T AU - Denckla, W D AU - Veech, R L AD - Lab. Metabolism. NIAAA, 12501 Washington Avenue, Rockville, MD 20852, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 192 EP - 197 VL - 5 IS - 2 SN - 0145-6008, 0145-6008 KW - levels KW - intake KW - alcohol KW - oxygen KW - rats KW - Toxicology Abstracts KW - chronic effects KW - thyroid KW - liver KW - hormones KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15279328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ALCOHOL.%2C+CLIN.+EXP.+RES.&rft.atitle=Effects+of+Chronic+Ethanol+Administration+on+O+sub%282%29+Consumption+in+Whole+Body+and+Perfused+Liver+of+the+Rat.&rft.au=Schaffer%2C+W+T%3BDenckla%2C+W+D%3BVeech%2C+R+L&rft.aulast=Schaffer&rft.aufirst=W&rft.date=1981-01-01&rft.volume=5&rft.issue=2&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=ALCOHOL.%2C+CLIN.+EXP.+RES.&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - chronic effects; thyroid; hormones; liver ER - TY - JOUR T1 - Induction of Aryl Hydrocarbon Hydroxylase and Epoxide Hydrolase in Rat Liver, Kidney, Testis, Prostate Glands, and Stomach by a Potent Nematocide, 1, 2-Dibromo-3-Chloropropane AN - 15242294; 42031 AB - Because of environmental contamination with 1,2-dibromo-3-chloropropane (DBCP), a potent nematocide, it has become necessary to assess its adverse biological effects. The present data describe the ability of DBCP to induce aryl hydrocarbon hydroxylase (AHH) and epoxide hydrolase (EH) activities in the liver, kidney,testis,prostate glands, and stomach of the male rat. DBCP induced AHH in all organs studied except the liver and prostate glands. Maximum induction of AHH appeared 8, 8, and 16 hr following treatment for stomach, kidney, and testis, respectively. At the maximum induction, AHH activity in testis, kidney, and stomach was 2.1, 3.8, and 4.7 times that of controls, respectively. EH activity was also induced at varying times following DBCP treatment in the liver, kidney, testis, and prostate glands. The maximum induction occurred at 48 hr in kidney and testis, and at 74 hr in liver and prostate glands. JF - TOXICOL. AND APPL. PHARMACOL. AU - Suzuki, K AU - Lee, I P AD - Lab. Reprod. and Devel. Toxicol., NIEHS, Res. Triangle Pk., NC Y1 - 1981 PY - 1981 DA - 1981 SP - 151 VL - 58 IS - 1 KW - Nematocide residues KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Pathology KW - Toxicants KW - Contamination KW - Hydrocarbons KW - Environmental impact KW - Pesticides KW - H SE4.20:POISONS AND POISONING KW - H SM0.8.2:CHEMICALS (CORROSION) KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15242294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=TOXICOL.+AND+APPL.+PHARMACOL.&rft.atitle=Induction+of+Aryl+Hydrocarbon+Hydroxylase+and+Epoxide+Hydrolase+in+Rat+Liver%2C+Kidney%2C+Testis%2C+Prostate+Glands%2C+and+Stomach+by+a+Potent+Nematocide%2C+1%2C+2-Dibromo-3-Chloropropane&rft.au=Suzuki%2C+K%3BLee%2C+I+P&rft.aulast=Suzuki&rft.aufirst=K&rft.date=1981-01-01&rft.volume=58&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=TOXICOL.+AND+APPL.+PHARMACOL.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Environmental impact; Contamination; Hydrocarbons; Toxicants; Pathology; Pesticides ER - TY - JOUR T1 - Expression of Metastatic Potential of Allogenic and Xenogeneic Neoplasms in Young Nude Mice AN - 15231949; 21329 AB - Several different mouse and rat tumors were injected s.c. or i.v. into specific-pathogen-free young (3-week-old) and adult (6-week-old) nude mice. All tumors grew s.c.; however, following i.v. injections, only metastatic neoplasms produced visible pulmonary tumor foci in the 3-week-old (but not in the 6-week old) nude mice. Based on results of the experiments, the authors concluded that specific-pathogen-free 3-week-old nude mice, which lack functional T-lymphocytes and demonstrate low natural killer cell activity, could serve as an in vivo model to ascertain the metastatic potential of allogeneic and xenogeneic tumors. JF - Cancer Research AU - Hanna, N AU - Fidler, I J AD - Cancer Metastasis, Treatment Lab., NCI Frederick Cancer Res. Ctr., Frederick, MD Y1 - 1981 PY - 1981 DA - 1981 SP - 438 EP - 444 PB - Maclean-Hunter Ltd. VL - 41 IS - 2 SN - 0008-5472, 0008-5472 KW - mice KW - Metastatic potentials KW - Allogenic neoplasms KW - Xenogeneic neoplasms KW - Neoplasms KW - Tumor injections KW - Health & Safety Science Abstracts KW - H SM10.21:CANCER UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15231949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Expression+of+Metastatic+Potential+of+Allogenic+and+Xenogeneic+Neoplasms+in+Young+Nude+Mice&rft.au=Hanna%2C+N%3BFidler%2C+I+J&rft.aulast=Hanna&rft.aufirst=N&rft.date=1981-01-01&rft.volume=41&rft.issue=2&rft.spage=438&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Quantitative characterization of polychlorinated biphenyl mixtures (Aroclors 1248, 1254 and 1260) by gas chromatography using capillary columns AN - 13906646; S198103266 AB - The compositions of Aroclors 1248, 1254 and 1260 have been determined by quantitative gas-liquid chromatography using glass capillary columns of a range of selectivities. The details of the procedure are given. These aroclors can be used as secondary standards to obtain relative molar responses for electron-capture detectors. JF - Journal of Chromatography AU - Albro, P W AU - Corbett, J T AU - Schroeder, J L AD - NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES, N.C. Y1 - 1981 PY - 1981 DA - 1981 SP - 103 EP - 111 VL - 205 IS - 1 SN - 0021-9673, 0021-9673 KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13906646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography&rft.atitle=Quantitative+characterization+of+polychlorinated+biphenyl+mixtures+%28Aroclors+1248%2C+1254+and+1260%29+by+gas+chromatography+using+capillary+columns&rft.au=Albro%2C+P+W%3BCorbett%2C+J+T%3BSchroeder%2C+J+L&rft.aulast=Albro&rft.aufirst=P&rft.date=1981-01-01&rft.volume=205&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography&rft.issn=00219673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Carcinogenesis of synthetic organic chemicals in drinking water AN - 13888198; 198103609 AB - Large numbers of organic chemicals have been identified as pollutants in water supplies. The author discusses the risk factors associated with six of these chemicals (carbon tetrachloride, chloroform, vinyl chloride, chlordane, dieldrin, and PCB), and recommends 5 experimental procedures for quantifying the risk of cancer from organic chemicals. JF - Journal of the American Water Resources Association AU - Kraybill, H F AD - National Cancer Institute Y1 - 1981 PY - 1981 DA - 1981 SP - 370 EP - 372 VL - 73 IS - 7 SN - 1093-474X, 1093-474X KW - Carbon tetrachloride KW - Hazard KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13888198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Water+Resources+Association&rft.atitle=Carcinogenesis+of+synthetic+organic+chemicals+in+drinking+water&rft.au=Kraybill%2C+H+F&rft.aulast=Kraybill&rft.aufirst=H&rft.date=1981-01-01&rft.volume=73&rft.issue=7&rft.spage=370&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Water+Resources+Association&rft.issn=1093474X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Possible factors in the drinking water of laboratory animals causing reproductive failure AN - 13879998; S198207433 AB - Following the observation that certain deficiencies in reproductive performance in laboratory strains of mice at the National Institute of Environmental Health Sciences could be eliminated by the supply of specially purified drinking water in place of ordinary tap water, an extensive investigation into the quality of the drinking water supply was undertaken. The raw water was obtained from a river which is relatively free of industrial pollution. Detailed studies of the formation of trihalomethanes and chlorinated organics as a result of the pre-chlorination step are described. Despite exhaustive investigations, no positive conclusion could be arrived at concerning the nature of the causative agent. Chloroform concentrations in the water were highest at the time when reproductive failures were their lowest and no association with chlorinated organics or other parameters could be demonstrated. Nevertheless studies of the reproductive behaviour of mice receiving graded amounts of chloroform in their drinking water showed a dose-related response, and decreases in embryonic development and decreased mating percentage at a concentration of 152 ppb. JF - Identification & Analysis of Organic Pollutants in Water (edited by L. H. Keith). Ann Arbor Science Publishers, Inc., Ann Arbor, Mich. AU - McKinney, J D AU - Maurer, R R AU - Hass, J R AU - Thomas, RO AD - National Institute of Environmental Health Sciences Y1 - 1981 PY - 1981 DA - 1981 SP - 22 EP - 432,22 KW - Animals (see also individual groups below) KW - Arriving KW - Pollution (s/a contamination, individ grps below) KW - Reduction KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13879998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Identification+%26+Analysis+of+Organic+Pollutants+in+Water+%28edited+by+L.+H.+Keith%29.+Ann+Arbor+Science+Publishers%2C+Inc.%2C+Ann+Arbor%2C+Mich.&rft.atitle=Possible+factors+in+the+drinking+water+of+laboratory+animals+causing+reproductive+failure&rft.au=McKinney%2C+J+D%3BMaurer%2C+R+R%3BHass%2C+J+R%3BThomas%2C+RO&rft.aulast=McKinney&rft.aufirst=J&rft.date=1981-01-01&rft.volume=&rft.issue=&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Identification+%26+Analysis+of+Organic+Pollutants+in+Water+%28edited+by+L.+H.+Keith%29.+Ann+Arbor+Science+Publishers%2C+Inc.%2C+Ann+Arbor%2C+Mich.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Exact significance levels for multiple binomial testing with application to carcinogenicity screens AN - 13876260; S198308785 AB - The authors consider a simple experimental design to evaluate significance levels in carcinogenicity screening. The design consists of one treatment and one control group. From the design they developed a method calculating the exact permutational probability of at least one significant Fisher-Irwin test, conditional on the observed marginal totals of animals with tumours. This is then extended to the multiple-treatment-single control group design. To save time on computation of exact probabilities, upper and lower Bonferron bounds on the desired probability were developed. An example and typical results are presented. JF - Biometrics AU - Brown, C C AU - Fears, T R AD - National Cancer Institute, Md Y1 - 1981 PY - 1981 DA - 1981 SP - 763 EP - 774 VL - 37 SN - 0006-341X, 0006-341X KW - Animals (see also individual groups below) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13876260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Exact+significance+levels+for+multiple+binomial+testing+with+application+to+carcinogenicity+screens&rft.au=Brown%2C+C+C%3BFears%2C+T+R&rft.aulast=Brown&rft.aufirst=C&rft.date=1981-01-01&rft.volume=37&rft.issue=&rft.spage=763&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Suppression of contact hypersensitivity by UV radiation and its relationship to UV-induced suppression of tumor immunity. AN - 13592555; 479077 AB - In this study, the authors examine some of the photobiologic and immunologic characteristics of the suppression of contact hypersensitivity (CHS) by UV radiation. BALB/c mice were irradiated on the shaved dorsal skin with FS40 sunlamps and sensitized 5 days later by applying a contact sensitizer to the shaved abdomen. The suppression of CHS resulting from exposure to a given total dose of UV radiation was unaffected by changes in dose fractionation over a 5-day period and by changes in dose-rate over a 10-fold range. Contact sensitization of UV-irradiated, but not unirradiated, mice induced the appearance of antigen-specific suppressor T lymphocytes in their spleen. The photobiologic and immunologic similarities between the suppression of CHS by UV radiation and the UV-mediated suppression of tumor rejection described previously suggest that these two immunosuppressive effects of UV exposure share certain steps in their pathways. JF - Photochemistry and Photobiology AU - Noonan, F P AU - De Fabo, EC AU - Kripke, M L AD - Cancer Biol. Program, NCI Frederick Cancer Res. Cent., Frederick, MD 21701, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 683 EP - 689 VL - 34 IS - 6 SN - 0031-8655, 0031-8655 KW - suppression KW - induction KW - contact sensitization KW - mice KW - Toxicology Abstracts; Immunology Abstracts KW - immunosuppression KW - hypersensitivity KW - U.V. radiation KW - F 06849:Delayed type KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13592555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+Photobiology&rft.atitle=Suppression+of+contact+hypersensitivity+by+UV+radiation+and+its+relationship+to+UV-induced+suppression+of+tumor+immunity.&rft.au=Noonan%2C+F+P%3BDe+Fabo%2C+EC%3BKripke%2C+M+L&rft.aulast=Noonan&rft.aufirst=F&rft.date=1981-01-01&rft.volume=34&rft.issue=6&rft.spage=683&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+Photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - hypersensitivity; U.V. radiation; immunosuppression ER - TY - JOUR T1 - Genesis on planet Earth; book review AN - 52629523; 1998-029561 JF - Organic Geochemistry AU - Black, Simon Y1 - 1980/10// PY - 1980 DA - October 1980 SP - 182 EP - 183 PB - Pergamon, Oxford-New York VL - 2 IS - 3-4 SN - 0146-6380, 0146-6380 KW - Earth KW - life origin KW - book reviews KW - 08:General paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52629523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+Geochemistry&rft.atitle=Genesis+on+planet+Earth%3B+book+review&rft.au=Black%2C+Simon&rft.aulast=Black&rft.aufirst=Simon&rft.date=1980-10-01&rft.volume=2&rft.issue=3-4&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Organic+Geochemistry&rft.issn=01466380&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/01466380 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - SuppNotes - By Day, William, The House of Talos Publishers, 1979 N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - book reviews; Earth; life origin ER - TY - JOUR T1 - Induction of sister chromatid exchanges by carcinogens mediated through cultured rat liver epithelial cells. AN - 74988133; 11219869 AB - A cloned, untransformed rat liver cell-line, LNRL (with the normal diploid karyotype and epithelial morphology) was tested for use as the metabolizing component in a co-cultivation system for carcinogen-screening using sister chromatid exchanges (SCE) as the criterion. The well characterized early cultures of LNRL cells were co-cultivated with Chinese hamster ovary (CHO) cells, the target commonly used for the induction of SCE, and exposed to different concentrations of various chemicals for 24 h. Two polycyclic hydrocarbons, 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene did not produce any SCE in CHO cells cultured alone, but produced a significant number of SCE in CHO co-cultivated with LNRL. The aromatic amine, 2-acetylaminofluorene, and the potent carcinogenic mycotoxin, aflatoxin B1, induced SCE to a limited extent even in CHO cells cultivated alone, but in the presence of liver cells the SCE frequency was greatly increased. Aflatoxin G2, the least potent of the aflatoxins, also produced a response in the co-cultivation system. These results indicate that cultured liver cells can be used as the metabolizing cells in co-cultivation systems for carcinogen-screening. The advantages of this assay over those employing liver microsomal fractions are discussed. JF - Carcinogenesis AU - Ray-Chaudhuri, R AU - Kelley, S AU - Iype, P T AD - Chemical Carcinogenesis Program, NCI Frederick Cancer Research Center, MD 21701, USA. Y1 - 1980/09// PY - 1980 DA - September 1980 SP - 779 EP - 786 VL - 1 IS - 9 SN - 0143-3334, 0143-3334 KW - Antimetabolites KW - 0 KW - Carcinogens KW - Mycotoxins KW - Benzo(a)pyrene KW - 3417WMA06D KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Bromodeoxyuridine KW - G34N38R2N1 KW - Index Medicus KW - Coculture Techniques KW - Animals KW - Rats, Inbred Lew KW - 2-Acetylaminofluorene -- toxicity KW - CHO Cells -- drug effects KW - 2-Acetylaminofluorene -- pharmacokinetics KW - Benzo(a)pyrene -- pharmacokinetics KW - Rats KW - Antimetabolites -- pharmacology KW - 9,10-Dimethyl-1,2-benzanthracene -- pharmacokinetics KW - Bromodeoxyuridine -- pharmacology KW - Epithelial Cells -- drug effects KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Benzo(a)pyrene -- toxicity KW - Mycotoxins -- pharmacokinetics KW - Carcinogenicity Tests KW - CHO Cells -- cytology KW - Mycotoxins -- toxicity KW - Male KW - Cell Line KW - Cricetinae KW - Liver -- cytology KW - Sister Chromatid Exchange KW - Liver -- drug effects KW - Carcinogens -- pharmacokinetics KW - Carcinogens -- toxicity KW - Liver -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/74988133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Induction+of+sister+chromatid+exchanges+by+carcinogens+mediated+through+cultured+rat+liver+epithelial+cells.&rft.au=Ray-Chaudhuri%2C+R%3BKelley%2C+S%3BIype%2C+P+T&rft.aulast=Ray-Chaudhuri&rft.aufirst=R&rft.date=1980-09-01&rft.volume=1&rft.issue=9&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2001-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Carcinogenicity of the isomeric, N-nitroso-delta3-and N-nitroso-delta2-piperidines in rats and the in vivo isomerization of the delta3-to the delta2-isomer. AN - 74959095; 11219865 AB - N-Nitroso-1,2,3,6-tetrahydropyridine (N-nitroso-delta3-piperidine), N-nitroso-1,2,3,4-tetrahydropyridine (N-nitroso-delta2-piperidine) and N-nitroso-3,4-epoxypiperidine were tested for carcinogenicity in Fischer 344 rats. The unsaturated nitrosamines were administered in drinking water (100 mg/l). The epoxide was administered by gavage in corn oil (11.5 mg/ml, 0.2 ml twice a week). Both of the unsaturated nitrosamines were potent carcinogens (most of the animals died by the 35th week), and both produced many esophageal tumors, a property which they have in common with the parent compound, N-nitrosopiperidine. The spectrum of the other tumors formed, however, was different. The delta3-isomer produced hemangioendothelial sarcomas in the liver, which were absent in the tumor spectrum of the delta2-isomer and N-nitrosopiperidine. The delta2-isomer, on the other hand, produced tumors of the forestomach and the oropharynx, which were essentially absent in the rats treated with the delta3-isomer. N-nitroso-3,4-epoxypiperidine was a toxic compound (8 deaths in the first 5 weeks), but most of the remaining animals survived to 40 weeks. Of these, 8 animals died of induced tumors (esophagus and liver). The delta2- and the delta3-isomers were administered by gavage to groups of rats and the blood of these animals was withdrawn at timed intervals. Analysis of the serum revealed that both of the nitrosamines were cleared rapidly from circulation but that at the same time the delta3-isomer was being isomerized to the delta2. The reverse transformation did not occur in vivo. JF - Carcinogenesis AU - Kupper, R AU - Reuber, M D AU - Blackwell, B N AU - Lijinsky, W AU - Koepke, S R AU - Michejda, C J AD - Chemical Carcinogenesis Program, NCI Frederick Cancer Research Center, MD 21701, USA. Y1 - 1980/09// PY - 1980 DA - September 1980 SP - 753 EP - 757 VL - 1 IS - 9 SN - 0143-3334, 0143-3334 KW - Carcinogens KW - 0 KW - Epoxy Compounds KW - Nitrosamines KW - N-nitrosopiperidine KW - 6N066XUL4L KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Isomerism KW - Epoxy Compounds -- chemistry KW - Carcinogenicity Tests KW - Epoxy Compounds -- toxicity KW - Oropharyngeal Neoplasms -- chemically induced KW - Male KW - Female KW - Structure-Activity Relationship KW - Digestive System Neoplasms -- chemically induced KW - Nitrosamines -- toxicity KW - Nitrosamines -- chemistry KW - Carcinogens -- pharmacokinetics KW - Carcinogens -- chemistry KW - Carcinogens -- toxicity KW - Nitrosamines -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/74959095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Carcinogenicity+of+the+isomeric%2C+N-nitroso-delta3-and+N-nitroso-delta2-piperidines+in+rats+and+the+in+vivo+isomerization+of+the+delta3-to+the+delta2-isomer.&rft.au=Kupper%2C+R%3BReuber%2C+M+D%3BBlackwell%2C+B+N%3BLijinsky%2C+W%3BKoepke%2C+S+R%3BMichejda%2C+C+J&rft.aulast=Kupper&rft.aufirst=R&rft.date=1980-09-01&rft.volume=1&rft.issue=9&rft.spage=753&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2001-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized preoperative and postoperative radiation therapy for patients with carcinoma of the head and neck: preliminary report. AN - 85177464; pmid-7382709 AB - Two hundred and ninety-eight patients with squamous cell carcinoma of the oral cavity, oropharynx, supraglottic larynx, hypopharynx or maxillary sinus have been randomized for preoperative radiation therapy and surgery vs. surgery and postoperative radiation therapy plus, in the case of patients with lesions of the oral cavity and oropharynx, radical radiation therapy. Data have been analyzed on 243 patients in this interim report. The differences between the three groups with respect to local control and survival are not statistically significant at this time. Additional accrual and continued follow-up are necessary to make definite treatment comparisons. JF - The Laryngoscope AU - Snow, J B AU - Gelber, R D AU - Kramer, S AU - Davis, L W AU - Marcial, V A AU - Lowry, L D AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1980 SP - 930 EP - 945 VL - 90 IS - 6 Pt 1 SN - 0023-852X, 0023-852X KW - Preoperative Care KW - Support, U.S. Gov't, P.H.S. KW - Oropharynx KW - Postoperative Care KW - Random Allocation KW - Human KW - Pharyngeal Neoplasms KW - Laryngeal Neoplasms KW - Hypopharynx KW - Mouth Neoplasms KW - Postoperative Complications KW - Head and Neck Neoplasms KW - Carcinoma, Squamous Cell KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85177464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Randomized+preoperative+and+postoperative+radiation+therapy+for+patients+with+carcinoma+of+the+head+and+neck%3A+preliminary+report.&rft.au=Snow%2C+J+B%3BGelber%2C+R+D%3BKramer%2C+S%3BDavis%2C+L+W%3BMarcial%2C+V+A%3BLowry%2C+L+D&rft.aulast=Snow&rft.aufirst=J&rft.date=1980-06-01&rft.volume=90&rft.issue=6+Pt+1&rft.spage=930&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effects of furosemide and ethacrynic acid on the endocochlear direct current potential in normal and kanamycin sulfate-treated guinea pigs. AN - 85197781; pmid-7402658 AB - The effects of loop diuretics on the endocochlear direct current (DC) potential and the effective electrical resistance of the cochlear partition were studied. The effective electrical resistance was increased, and the endocohlear DC potential was decreased. The decrease in the endocohlear DC potential must not be caused by breaks in the electrical insulation of the cochlear partition. With loop diuretics the endocochlear DC potential decreased less in guinea pigs treated with kanamycin sulfate than it did in the control group. Two interpretations of these phenomena are presented. JF - Otolaryngology--Head and Neck Surgery AU - Asakuma, S AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1980 SP - 188 EP - 193 VL - 88 IS - 2 SN - 0194-5998, 0194-5998 KW - Cochlea KW - Sulfates KW - Ethacrynic Acid KW - Hair Cells KW - Electric Conductivity KW - Guinea Pigs KW - Animal KW - Kanamycin KW - Electrophysiology KW - Furosemide KW - Comparative Study KW - Stria Vascularis KW - Sodium Chloride UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85197781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Effects+of+furosemide+and+ethacrynic+acid+on+the+endocochlear+direct+current+potential+in+normal+and+kanamycin+sulfate-treated+guinea+pigs.&rft.au=Asakuma%2C+S%3BSnow%2C+J+B&rft.aulast=Asakuma&rft.aufirst=S&rft.date=1980-03-01&rft.volume=88&rft.issue=2&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - High-affinity t-cell rosettes: The effects of clinical manipulations and potential prognostic significance AN - 754561410; 13378846 AB - Incubation of blood mononuclear cells with sheep erythrocytes at 29C identifies high-affinity rosette-forming T-cells (RFC). The proportion of highaffinity RFC was more frequently depressed in patients with cancer than the total number of RFC identified under optimal rosetting conditions. Our purpose was to determine the effect of chemotherapy and/or immunotherapy on the level of RFC and to determine whether trends in serial values had prognostic significance. Two hundred thirty-seven of 270 normal individuals tested had 29C RFC levels greater than or equal to 47%, while 21 of 41 untreated cancer patients had higher levels. Cancer patients with depressed 29C RFC usually normalized within four weeks of operation. Serial studies of 29C RFC were performed on 32 stage I and II lung cancer patients. Eight patients have developed recurrent tumor. We noted a pattern of falling rosette values (two or more consecutive values within normal limits followed by two consecutive depressed values) in five of these patients an average of five months before clinical relapse. Fifteen patients who have remained disease free either maintained normal levels of rosettes or increased into the normal range. Four of 13 (31%) stage I and four of nine (44%) stage II breast cancer patients had depressed rosette levels preoperatively. In seven stage II patients with no further therapy after mastectomy, only two of 27 serial tests showed low RFC. Twenty-six stage II patients receiving L-phenylalanine mustard (L-PAM) therapy after mastectomy were depressed in 18 of 90 (20%) serial tests. Twenty-one patients receiving cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) after mastectomy were depressed in 25 of 73 (34%) serial tests. In contrast, seven patients treated with CMF and additionally with Corynebacterium parvum after mastectomy were depressed in eight of 27, or 29%, of serial tests. The 29C E-rosette assay gives reproducible counts of a T-cell subset. Serial monitoring of patients with high-affinity rosette-forming cells may predict relapse earlier than clinical evaluation. This T-cell population, depressed by chemotherapy, may be restored by immunopotentiators. JF - Journal of Surgical Oncology AU - Weese, James L AU - West, William H AU - Herberman, Ronald B AU - Payne, Susan M AU - Siwarski, Joyce W AU - Turcotte, Jeremiah G AD - Laboratory of Immunodiagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland PY - 1980 SP - 145 EP - 153 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 13 IS - 2 SN - 0022-4790, 0022-4790 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Rosette KW - Leukocytes (mononuclear) KW - Depression KW - Immunotherapy KW - Chemotherapy KW - Erythrocytes KW - Tumors KW - Cyclophosphamide KW - Phenylalanine KW - Corynebacterium KW - Blood KW - 5-Fluorouracil KW - Lymphocytes T KW - Methotrexate KW - Breast cancer KW - Lung cancer KW - F 06915:Cancer Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754561410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Surgical+Oncology&rft.atitle=High-affinity+t-cell+rosettes%3A+The+effects+of+clinical+manipulations+and+potential+prognostic+significance&rft.au=Weese%2C+James+L%3BWest%2C+William+H%3BHerberman%2C+Ronald+B%3BPayne%2C+Susan+M%3BSiwarski%2C+Joyce+W%3BTurcotte%2C+Jeremiah+G&rft.aulast=Weese&rft.aufirst=James&rft.date=1980-02-01&rft.volume=13&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Journal+of+Surgical+Oncology&rft.issn=00224790&rft_id=info:doi/10.1002%2Fjso.2930130210 L2 - http://www3.interscience.wiley.com/journal/112720291/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Rosette; Leukocytes (mononuclear); Depression; Chemotherapy; Immunotherapy; Erythrocytes; Cyclophosphamide; Tumors; Phenylalanine; Blood; 5-Fluorouracil; Lymphocytes T; Breast cancer; Methotrexate; Lung cancer; Corynebacterium DO - http://dx.doi.org/10.1002/jso.2930130210 ER - TY - JOUR T1 - LITHIUM NEUROTOXICITY AT 'THERAPEUTIC' LEVELS A CASE REPORT AN - 920797805; 16207935 AB - A case of a young manic patient who developed severe neurotoxicity when on lithium alone has been presented. Investigations did not reveal presence of any infection, electrolyte imbalance or rise in lithium level. The possibility of lithium producing neurotoxicity at therapeutic levels for as yet unknown reasons is pointed out. It is suggested that this element of risk be considered when starting lithium for therapy or prophylaxis of affective disorders. JF - Indian Journal of Psychiatry AU - Sampath, G AU - Kumar, YVikram AU - Narayanan, H S AU - Rama Rao, BSSridhara AD - ,2,3Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore. Y1 - 1980 PY - 1980 DA - 1980 SP - 304 EP - 306 PB - Medknow Publications Pvt. Ltd., A-108/109 Kanara Business Center Mumbai 400075 India VL - 22 IS - 3 SN - 0019-5545, 0019-5545 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Affective disorders KW - electrolytes KW - Infection KW - Case reports KW - Neurotoxicity KW - infection KW - Prophylaxis KW - Lithium KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920797805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+Journal+of+Psychiatry&rft.atitle=LITHIUM+NEUROTOXICITY+AT+%27THERAPEUTIC%27+LEVELS+A+CASE+REPORT&rft.au=Sampath%2C+G%3BKumar%2C+YVikram%3BNarayanan%2C+H+S%3BRama+Rao%2C+BSSridhara&rft.aulast=Sampath&rft.aufirst=G&rft.date=1980-01-01&rft.volume=22&rft.issue=3&rft.spage=304&rft.isbn=&rft.btitle=&rft.title=Indian+Journal+of+Psychiatry&rft.issn=00195545&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Case reports; Affective disorders; Neurotoxicity; Prophylaxis; Infection; Lithium; infection; electrolytes ER - TY - JOUR T1 - Adenocarcinoma of the ethmoid following radiotherapy for bilateral retinoblastoma. AN - 85177065; pmid-6766200 AB - Adenocarcinoma of the ethmoid sinus is rare, representing only 4-8% of malignancies of the paranasal sinuses. An extraordinary case of papillary adenocarcinoma of the ethmoid sinus arising 30 years following high-dose radiotherapy for bilateral retinoblastoma is presented. Retinoblastoma, though occurring only once in every 23,000 to 34,000 births, is the most common malignant intraocular tumor of childhood. Second fatal mesenchymal and epithelial primaries have been described in 8.5% of patients with bilateral retinoblastomas previously treated with radiotherapy; however, papillary adenocarcinoma arising within the paranasal sinuses has not been reported. Histologically, the findings of a papillary pattern of poorly differentiated, mucicarmine-staining cells enclosing gland-like spaces, and the absence of pseudorosettes, melanin, mesenchymal and peripheral neural elements supports an epithelial origin of this tumor. Agressive treatment including partial maxillectomy, radical pansinusectomy, radical neck dissection followed by regional radiotherapy and systemic chemotherapy failed to prevent the development of fatal hepatic metastases. The high incidence of second fatal primary neoplasms in patients with bilateral retinoblastomas receiving radiation suggests an innate susceptibility that may add to the risk of radiotherapy. Careful long-term head and neck surveillance is mandatory if early aggressive management of these extremely lethal tumors is to be successful. JF - The Laryngoscope AU - Rowe, L D AU - Lane, R AU - Snow, J B AD - National Institute on Deafness and other Communication Disorders, Bethesda, Maryland 20892, USA. PY - 1980 SP - 61 EP - 69 VL - 90 IS - 1 SN - 0023-852X, 0023-852X KW - Adenocarcinoma, Papillary KW - Eye Neoplasms KW - Paranasal Sinus Neoplasms KW - Human KW - Adult KW - Case Report KW - Retinoblastoma KW - Time Factors KW - Male KW - Radiotherapy, High-Energy KW - Ethmoid Sinus KW - Neoplasms, Radiation-Induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85177065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Adenocarcinoma+of+the+ethmoid+following+radiotherapy+for+bilateral+retinoblastoma.&rft.au=Rowe%2C+L+D%3BLane%2C+R%3BSnow%2C+J+B&rft.aulast=Rowe&rft.aufirst=L&rft.date=1980-01-01&rft.volume=90&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Tumor promoter produces anchorage independence in mouse epidermal cells by an induction mechanism. AN - 74967638; 11219849 AB - The irreversible shift in anchorage independence by phorbol ester responsive mouse epidermal cell lines appears to occur not by a mechanism involving selection of preexisting transformants but by induction of a new phenotype. JF - Carcinogenesis AU - Colburn, N H AD - Laboratory of Experimental Pathology, National Cancer Institute, Bethesda, MD 20205, USA. Y1 - 1980 PY - 1980 DA - 1980 SP - 951 EP - 954 VL - 1 IS - 11 SN - 0143-3334, 0143-3334 KW - Carcinogens KW - 0 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Mice KW - Cell Adhesion -- drug effects KW - Cell Line KW - Tetradecanoylphorbol Acetate -- toxicity KW - Epidermis -- drug effects KW - Cell Transformation, Neoplastic -- pathology KW - Epidermis -- cytology KW - Carcinogens -- toxicity KW - Cell Transformation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/74967638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Tumor+promoter+produces+anchorage+independence+in+mouse+epidermal+cells+by+an+induction+mechanism.&rft.au=Colburn%2C+N+H&rft.aulast=Colburn&rft.aufirst=N&rft.date=1980-01-01&rft.volume=1&rft.issue=11&rft.spage=951&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2001-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantitative assay for carcinogen altered differentiation in mouse epidermal cells. AN - 74963860; 11272116 AB - Basal epidermal cells can be selectively maintained as a monolayer in culture medium containing a low ionic calcium concentration of 0.01-0.10 mM. Cessation of proliferation, maturation and shedding of squamous sheets can be induced in this population by increasing the calcium concentration above 0.1 mM. Since alterations in the regulation of proliferation and differentiation are associated with epidermal carcinogenesis in vivo, it appeared reasonable that changes in the phenotypic response to calcium might follow exposure to carcinogens in vitro. Support for this hypothesis was provided by the observation that malignant epidermal cells continued to proliferate when switched from low to high calcium medium, and could thus be selected from a mixture of such cells and a large excess of normal cells which did not survive after induced differentiation. Normal primary epidermal cells were plated in low calcium medium, treated on day 3 with a chemical carcinogen, maintained for 3-9 weeks in low calcium (0.02 mM) and then switched to high calcium medium (1.4 mM). After an additional 4 weeks, surviving epithelial colonies were fixed, stained with rhodamine and counted. Treatment of cultures with 7,12-dimethylbenz[a]anthracene or N-methyl-N'-nitro-N-nitrosoguanidine yielded 4-10 fold more colonies than solvent controls. Colony number was proportional to carcinogen dose for both agents, and increased with time in low calcium prior to selection by calcium increase. Cells obtained from colonies in treated cultures demonstrated characteristic epidermal morphology and keratinization, and could be subcultured, but did not grow in agar or produce tumors in syngeneic hosts. This model system represents a quantitative assay for carcinogen altered epithelial cell differentiation and may select for an early property of preneoplastic epidermal cells. JF - Carcinogenesis AU - Kulesz-Martin, M F AU - Koehler, B AU - Hennings, H AU - Yuspa, S H AD - Laboratory of Experimental Pathology, National Cancer Institute, Bethesda, MD 20205, USA. Y1 - 1980 PY - 1980 DA - 1980 SP - 995 EP - 1006 VL - 1 IS - 12 SN - 0143-3334, 0143-3334 KW - Carcinogens KW - 0 KW - Coloring Agents KW - Rhodamines KW - Methylnitronitrosoguanidine KW - 12H3O2UGSF KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Coculture Techniques KW - Dose-Response Relationship, Drug KW - Cell Division -- drug effects KW - Calcium -- pharmacology KW - Cells, Cultured -- drug effects KW - Mice KW - Mice, Inbred BALB C KW - Phenotype KW - Cell Line, Transformed -- pathology KW - Cell Differentiation -- drug effects KW - Staining and Labeling KW - Cell Adhesion KW - Epidermis -- drug effects KW - Cell Transformation, Neoplastic -- pathology KW - Methylnitronitrosoguanidine -- toxicity KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Epidermis -- cytology KW - Cell Transformation, Neoplastic -- chemically induced KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/74963860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leiden+Journal+of+International+Law&rft.atitle=BIBLIOGRAPHY&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2017-03-01&rft.volume=30&rft.issue=1&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Leiden+Journal+of+International+Law&rft.issn=09221565&rft_id=info:doi/10.1017%2FS0922156516000716 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-29 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Altered Noradrenergic Systems in the Lead-Exposed Neonatal Rat. AN - 15449407; 264332 AB - Exposure to lead in the first 21 days of life consistently produced elevations in blood and tissue lead levels and alterations in steady state norepinephrine (NE), dopamine beta -hydroxylase (DBH) and phenylethanolamine N-methyl-transferase (PNMT) levels without growth delay in suckling rats. Elevations in brainstem DBH and PNMT of 36% and 46%, respectivively, supported the concept of increased central adrenergic turnover following exposure to lead. Serum NE increased from 47.2 plus or minus 4.8 ( plus or minus SEM) in control rats to 104.8 plus or minus 19.7 pg/ml in rats whose mothers were given drinking water with 0.2% lead acetate. Adrenal NE levels increased 53%, to 19.5 plus or minus 0.9 ng/mg protein, and adrenal weights were up 26% (p < 0.01). Heart weights were significantly greater and heart NE levels were lower at the highest level of lead exposure. It is suggested that increments in brainstem and peripheral adrenergic turnover are produced in neonatal rats given lead. JF - NEUROBEHAV. TOXICOL. AU - Goldman, D AU - Hejtmancik, Jr AU - Williams, B J AU - Ziegler, M G AD - Alcohol, Drug Abuse Mental Hlth. Adm., NIMH, Build. 36, Rm. 3A19, 9000 Rockville Pike, Bethesda, MD 20205, USA Y1 - 1980 PY - 1980 DA - 1980 SP - 337 EP - 343 VL - 2 IS - 4 KW - effects on KW - lead KW - noradrenaline KW - rats KW - Toxicology Abstracts KW - sympathetic nervous system KW - juveniles KW - X 24162:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15449407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leiden+Journal+of+International+Law&rft.atitle=Corporations+before+International+Criminal+Courts%3A+Implications+for+the+International+Criminal+Justice+Project&rft.au=KYRIAKAKIS%2C+JOANNA&rft.aulast=KYRIAKAKIS&rft.aufirst=JOANNA&rft.date=2017-03-01&rft.volume=30&rft.issue=1&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Leiden+Journal+of+International+Law&rft.issn=09221565&rft_id=info:doi/10.1017%2FS0922156516000650 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - sympathetic nervous system; juveniles ER - TY - JOUR T1 - Carcinogenicity and Toxicity of Methoxychlor. AN - 15272434; 110482 AB - A review. JF - Environmental Health Perspectives AU - Reuber, MD AD - Exp. Pathol. Lab., NCI Frederick Cancer Ctr., Frederick, MD 21701, USA Y1 - 1980 PY - 1980 DA - 1980 SP - 205 EP - 219 VL - 36 SN - 0091-6765, 0091-6765 KW - methoxychlor KW - Toxicology Abstracts KW - reviews KW - toxicity KW - carcinogenesis KW - animal models KW - X 24190:Polycyclic hydrocarbons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15272434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Carcinogenicity+and+Toxicity+of+Methoxychlor.&rft.au=Reuber%2C+MD&rft.aulast=Reuber&rft.aufirst=MD&rft.date=1980-01-01&rft.volume=30&rft.issue=1&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Leiden+Journal+of+International+Law&rft.issn=09221565&rft_id=info:doi/10.1017%2FS092215651600056X LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - carcinogenesis; toxicity; animal models; reviews ER - TY - JOUR T1 - Positive Correlation Between Histological Tumor Involvement and Generation of Tumor Cell Colonies in Agarose in Specimens Taken Directly From Patients With Small-Cell Carcinoma of the Lung AN - 15251304; 54107 AB - Twenty-seven specimens for in vitro agarose clonogenicity testing were obtained from 25 patients with small-cell carcimona of the lung (SCCL). The specimens were obtained from bone marrows, pleural effusions, lymph nodes, and liver biopsies. Colony fromation was seen in 14 of 15 specimens that were histologically involved with SCCL. Cytological examination of the agarose colonies confirmed their SCCL origin. None of the 100 clones picked from these specimens demonstrated the ability to continuously replicate in vitro . These results show an excellent correlation between agarose colony formation and histological tumor involvment and a more rapid in vitro doubling time than that seen in vivo . JF - Cancer Research AU - Carney, D N AU - Gazdar, A F AU - Minna, J D AD - NCI-VA Med. Oncol. Br., Div. Cancer Treat., Nat. Cancer Inst., WA VA Med. Ctr., Wash., DC Y1 - 1980 PY - 1980 DA - 1980 SP - 1820 EP - 1823 PB - Maclean-Hunter Ltd. VL - 40 IS - 6 SN - 0008-5472, 0008-5472 KW - Health & Safety Science Abstracts KW - Histology KW - Cancer KW - Respiratory pathology KW - H SM10.21:CANCER UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15251304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Positive+Correlation+Between+Histological+Tumor+Involvement+and+Generation+of+Tumor+Cell+Colonies+in+Agarose+in+Specimens+Taken+Directly+From+Patients+With+Small-Cell+Carcinoma+of+the+Lung&rft.au=Carney%2C+D+N%3BGazdar%2C+A+F%3BMinna%2C+J+D&rft.aulast=Carney&rft.aufirst=D&rft.date=1980-01-01&rft.volume=40&rft.issue=6&rft.spage=1820&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Histology; Cancer; Respiratory pathology ER - TY - JOUR T1 - Acute Effects of Cigarette Smoke Inhalation on the Syrian Hamster Lungs AN - 15231171; 2429 AB - Syrian golden hamsters were exposed to the smoke from a number of experimental cigarettes which contained differing amounts of nicotine and carbon monoxide. Pulmonary hemorrhages were induced, the number of which were clearly dependent on the nicotine content of the cigarette smoke. Electron microscopy revealed cytoplasmic swelling and ruptured cell membranes in alveolar type 1 cells and endothelial cells. JF - J. ENVIRON. PATHOL. AND TOXICOL. AU - Reznik-Schuller, H M AD - Carcinogenesis Prog., NCI Frederick Cancer Res. Ctr., Frederick, MD Y1 - 1980 PY - 1980 DA - 1980 SP - 285 EP - 291 VL - 4 IS - 1 KW - hamsters KW - Cigarette smoke inhalation KW - Pulmonary hemorrhage KW - Electron microscopy KW - Cytoplasmic swelling KW - Alveolar cells KW - Endothelial cells KW - Membrane rupturing KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Carbon monoxide KW - Nicotine KW - H SE4.26:DRUGS AND ALCOHOL KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15231171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=J.+ENVIRON.+PATHOL.+AND+TOXICOL.&rft.atitle=Acute+Effects+of+Cigarette+Smoke+Inhalation+on+the+Syrian+Hamster+Lungs&rft.au=Reznik-Schuller%2C+H+M&rft.aulast=Reznik-Schuller&rft.aufirst=H&rft.date=1980-01-01&rft.volume=4&rft.issue=1&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=J.+ENVIRON.+PATHOL.+AND+TOXICOL.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Nicotine; Carbon monoxide ER -